High-Energy Trauma and Damage Control in the Lower Limb

DTIC Science & Technology

2010-01-01

Reconstruction : From Microsurgery Reconstruction to Transplantation; Guest Editors, Chih-Hung Lin, M.D., and Fu-Chan Wei, M.D. Semin Plast Surg...continue intraoperatively.12–14 The goal is to achieve hemostasis, restore normal physiology, and potentially complete a vascular reconstruction upon...injuries and the need for vascular reconstruction at the time of admission is crucial to the success of grafting and maximizes the chances of limb

A New Interface Specification Methodology and its Application to Transducer Synthesis

DTIC Science & Technology

1988-05-01

structural, and physical. Within each domain descriptive methods are distinguished by the level of abstraction they emphasize. The Gajski -Kuhn Y...4.2. The Gajski -Kuhn Y-chart’s three axes correspond to three different domains for describing designs: behavioral, structural, and physical. The...Gajski83] D. Gajski , R. Kuhn, Guest Editors’ Introduction: New VLSI Tools, IEEE Computer, Vol. 16, No. 12, December 1983. [Girczyc85] E. Girczyc, R

PREFACE: 31st European Physical Society Conference on Plasma Physics

NASA Astrophysics Data System (ADS)

Dendy, Richard

2004-12-01

This special issue of Plasma Physics and Controlled Fusion comprises refereed papers contributed by invited speakers at the 31st European Physical Society Conference on Plasma Physics. The conference was jointly hosted by the Rutherford Appleton Laboratory, by the EURATOM/UKAEA Fusion Association and by Imperial College London, where it took place from 28 June to 2 July 2004. The overall agenda for this conference was set by the Board of the Plasma Physics Division of the European Physical Society, chaired by Friedrich Wagner (MPIPP, Garching) and his successor Jo Lister (CRPP, Lausanne). It built on developments in recent years, by further increasing the scientific diversity of the conference programme, whilst maintaining its depth and quality. A correspondingly diverse Programme Committee was set up, whose members are listed below. The final task of the Programme Committee has been the preparation of this special issue. In carrying out this work, as in preparing the scientific programme of the conference, the Programme Committee formed specialist subcommittees representing the different fields of plasma science. The chairmen of these subcommittees, in particular, accepted a very heavy workload on behalf of their respective research communities. It is a great pleasure to take this opportunity to thank: Emilia R Solano (CIEMAT, Madrid), magnetic confinement fusion; Jürgen Meyer-ter-Vehn (MPQ, Garching), laser-plasma interaction and beam plasma physics; and Jean-Luc Dorier (CRPP, Lausanne), dusty plasmas. The relatively few papers in astrophysical and basic plasma physics were co-ordinated by a small subcommittee which I led. Together with Peter Norreys (RAL, Chilton), we five constitute the editorial team for this special issue. The extensive refereeing load, compressed into a short time interval, was borne by the Programme Committee members and by many other experts, to whom this special issue owes much. We are also grateful to the Local Organizing Committee chaired by Henry Hutchinson (RAL, Chilton), and to the Plasma Physics and Controlled Fusion journal team (Institute of Physics Publishing, Bristol), for their work on this conference. At the 2004 European Physical Society Conference on Plasma Physics, plenary invited speakers whose talks spanned the entire field were followed, each day, by multiple parallel sessions which also included invited talks. Invited speakers in both these categories were asked to contribute papers to this special issue (the contributed papers at this conference, and at all recent conferences in this series, are archived at http://epsppd.epfl.ch). The Programme Committee is very grateful to the many invited speakers who have responded positively to this request. Invited papers appear here in their order of presentation during the week beginning 28 June 2004; this ordering provides an echo of the character of the conference, as it was experienced by those who took part. Programme Committee 2004 Professor Richard Dendy UKAEA Culham Division, UK Chairman and guest editor Dr Jean-Luc Dorier Centre de Recherches en Physique des Plasmas, Lausanne, Switzerland (Co-ordinator of dusty plasmas and guest editor) Professor Jürgen Meyer-ter-Vehn Max-Planck-Institut für Quantenoptik, Garching, Germany (Co-ordinator of laser-plasma interaction and beam plasma physics and guest editor) Dr Peter Norreys Rutherford Appleton Laboratory, Chilton, UK (Scientific Secretary and guest editor) Dr Emilia R Solano CIEMAT Laboratorio Nacional de Fusión, Madrid, Spain ( Co-ordinator of magnetic confinement fusion and guest editor) Dr Shalom Eliezer Soreq Nuclear Research Centre, Israel Dr Wim Goedheer FOM-Instituut voor Plasmafysica, Rijnhuizen, Netherlands Professor Henry Hutchinson Rutherford Appleton Laboratory, Chilton, UK Professor John Kirk Max-Planck-Institut für Kernphysik, Heidelberg, Germany Dr Raymond Koch Ecole Royale Militaire/Koninklijke Militaire School, Brussels, Belgium Professor Gerrit Kroesen Technische Universiteit Eindhoven, Netherlands Dr Martin Lampe Naval Research Laboratory, Washington DC, USA Dr Jo Lister Centre de Recherches en Physique des Plasmas, Lausanne, Switzerland Dr Paola Mantica Istituto di Fisica del Plasma, Milan, Italy Professor Tito Mendonca Instituto Superior Tecnico, Lisbon, Portugal Dr Patrick Mora École Polytechnique, Palaiseau, France Professor Lennart Stenflo Umeå Universitet, Sweden Professor Paul Thomas CEA Cadarache, Saint-Paul-lez-Durance, France Professor Friedrich Wagner Max-Planck-Institut fr Plasmaphysik, Garching, Germany Professor Hannspeter Winter Technische Universität Wien, Austria

Using Globus to Transfer and Share Big Data | Poster

Cancer.gov

By Ashley DeVine, Staff Writer, and Mark Wance, Guest Writer; photo by Richard Frederickson, Staff Photographer Editor's note: This article was updated April 30, 2018. Transferring big data, such as the genomics data delivered to customers from the Center for Cancer Research Sequencing Facility (CCR SF), has been difficult in the past because the transfer systems have not kept pace with the size of the data. However, the situation is changing as a result of the Globus project.

Preface: Challenges for Catalytic Exhaust Aftertreatment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nova, Isabella; Epling, Bill; Peden, Charles HF

2014-03-31

This special issue of Catalysis Today continues the tradition established since the 18th NAM in Cancun, 2003, of publishing the highlights coming from these catalytic after-treatment technologies sessions, where this volume contains 18 papers based on oral and poster presentations of the 23rd NAM, 2013. The guest editors would like to thank all of the catalyst scientists and engineers who presented in the "Emission control" sessions, and especially the authors who contributed to this special issue of Catalysis Today.

Honorary and ghost authorship in nursing publications.

PubMed

Kennedy, Maureen Shawn; Barnsteiner, Jane; Daly, John

2014-11-01

The purposes of this study were to (a) assess the prevalence of articles with honorary authors and ghost authors in 10 leading peer-reviewed nursing journals between 2010 to 2012; (b) compare the results to prevalence reported by authors of articles published in high-impact medical journals; and (c) assess the experiences of editors in the International Academy of Nursing Editors with honorary and guest authorship. Corresponding authors of articles published in 10 nursing journals between 2010 and 2012 were invited to complete an online survey about the contributions of coauthors to see if the International Committee of Medical Journal Editors () criteria for authorship were met. Additionally, members of the International Academy of Nursing Editors were invited to complete an online survey about their experiences in identifying honorary or ghost authors in articles submitted for publication. The prevalence of articles published in 10 nursing journals with honorary authors was 42%, and the prevalence of ghost authorship was 27.6%. This is a greater prevalence than what has been reported among medical journals. Qualitative data yielded five themes: lack of awareness around the rules for authorship; acknowledged need for debate, discussion, and promotion of ethical practice; knowingly tolerating, and sometimes deliberately promoting, transgressions in practice; power relations and expectations; and avoiding scrutiny. Among the 60 respondents to the editor survey, 22 (36.7%) reported identifying honorary authors and 13 (21.7%) reported ghost authors among papers submitted to their publications. Inappropriate authorship is a significant problem among scholarly nursing publications. If nursing scholarship is to maintain integrity and be considered trustworthy, and if publications are to be a factor in professional advancement, editors, nursing leaders, and faculty need to disseminate and adhere to ethical authorship practices. © 2014 Sigma Theta Tau International.

EDITORIAL: Introduction to the special issue on electromagnetic inverse problems: emerging methods and novel applications Introduction to the special issue on electromagnetic inverse problems: emerging methods and novel applications

NASA Astrophysics Data System (ADS)

Dorn, O.; Lesselier, D.

2010-07-01

Inverse problems in electromagnetics have a long history and have stimulated exciting research over many decades. New applications and solution methods are still emerging, providing a rich source of challenging topics for further investigation. The purpose of this special issue is to combine descriptions of several such developments that are expected to have the potential to fundamentally fuel new research, and to provide an overview of novel methods and applications for electromagnetic inverse problems. There have been several special sections published in Inverse Problems over the last decade addressing fully, or partly, electromagnetic inverse problems. Examples are: Electromagnetic imaging and inversion of the Earth's subsurface (Guest Editors: D Lesselier and T Habashy) October 2000 Testing inversion algorithms against experimental data (Guest Editors: K Belkebir and M Saillard) December 2001 Electromagnetic and ultrasonic nondestructive evaluation (Guest Editors: D Lesselier and J Bowler) December 2002 Electromagnetic characterization of buried obstacles (Guest Editors: D Lesselier and W C Chew) December 2004 Testing inversion algorithms against experimental data: inhomogeneous targets (Guest Editors: K Belkebir and M Saillard) December 2005 Testing inversion algorithms against experimental data: 3D targets (Guest Editors: A Litman and L Crocco) February 2009 In a certain sense, the current issue can be understood as a continuation of this series of special sections on electromagnetic inverse problems. On the other hand, its focus is intended to be more general than previous ones. Instead of trying to cover a well-defined, somewhat specialized research topic as completely as possible, this issue aims to show the broad range of techniques and applications that are relevant to electromagnetic imaging nowadays, which may serve as a source of inspiration and encouragement for all those entering this active and rapidly developing research area. Also, the construction of this special issue is likely to have been different from preceding ones. In addition to the invitations sent to specific research groups involved in electromagnetic inverse problems, the Guest Editors also solicited recommendations, from a large number of experts, of potential authors who were thereupon encouraged to contribute. Moreover, an open call for contributions was published on the homepage of Inverse Problems in order to attract as wide a scope of contributions as possible. This special issue's attempt at generality might also define its limitations: by no means could this collection of papers be exhaustive or complete, and as Guest Editors we are well aware that many exciting topics and potential contributions will be missing. This, however, also determines its very special flavor: besides addressing electromagnetic inverse problems in a broad sense, there were only a few restrictions on the contributions considered for this section. One requirement was plausible evidence of either novelty or the emergent nature of the technique or application described, judged mainly by the referees, and in some cases by the Guest Editors. The technical quality of the contributions always remained a stringent condition of acceptance, final adjudication (possibly questionable either way, not always positive) being made in most cases once a thorough revision process had been carried out. Therefore, we hope that the final result presented here constitutes an interesting collection of novel ideas and applications, properly refereed and edited, which will find its own readership and which can stimulate significant new research in the topics represented. Overall, as Guest Editors, we feel quite fortunate to have obtained such a strong response to the call for this issue and to have a really wide-ranging collection of high-quality contributions which, indeed, can be read from the first to the last page with sustained enthusiasm. A large number of applications and techniques is represented, overall via 16 contributions with 45 authors in total. This shows, in our opinion, that electromagnetic imaging and inversion remain amongst the most challenging and active research areas in applied inverse problems today. Below, we give a brief overview of the contributions included in this issue, ordered alphabetically by the surname of the leading author. 1. The complexity of handling potential randomness of the source in an inverse scattering problem is not minor, and the literature is far from being replete in this configuration. The contribution by G Bao, S N Chow, P Li and H Zhou, `Numerical solution of an inverse medium scattering problem with a stochastic source', exemplifies how to hybridize Wiener chaos expansion with a recursive linearization method in order to solve the stochastic problem as a set of decoupled deterministic ones. 2. In cases where the forward problem is expensive to evaluate, database methods might become a reliable method of choice, while enabling one to deliver more information on the inversion itself. The contribution by S Bilicz, M Lambert and Sz Gyimóthy, `Kriging-based generation of optimal databases as forward and inverse surrogate models', describes such a technique which uses kriging for constructing an efficient database with the goal of achieving an equidistant distribution of points in the measurement space. 3. Anisotropy remains a considerable challenge in electromagnetic imaging, which is tackled in the contribution by F Cakoni, D Colton, P Monk and J Sun, `The inverse electromagnetic scattering problem for anisotropic media', via the fact that transmission eigenvalues can be retrieved from a far-field scattering pattern, yielding, in particular, lower and upper bounds of the index of refraction of the unknown (dielectric anisotropic) scatterer. 4. So-called subspace optimization methods (SOM) have attracted a lot of interest recently in many fields. The contribution by X Chen, `Subspace-based optimization method for inverse scattering problems with an inhomogeneous background medium', illustrates how to address a realistic situation in which the medium containing the unknown obstacles is not homogeneous, via blending a properly developed SOM with a finite-element approach to the required Green's functions. 5. H Egger, M Hanke, C Schneider, J Schöberl and S Zaglmayr, in their contribution `Adjoint-based sampling methods for electromagnetic scattering', show how to efficiently develop sampling methods without explicit knowledge of the dyadic Green's function once an adjoint problem has been solved at much lower computational cost. This is demonstrated by examples in demanding propagative and diffusive situations. 6. Passive sensor arrays can be employed to image reflectors from ambient noise via proper migration of cross-correlation matrices into their embedding medium. This is investigated, and resolution, in particular, is considered in detail, as a function of the characteristics of the sensor array and those of the noise, in the contribution by J Garnier and G Papanicolaou, `Resolution analysis for imaging with noise'. 7. A direct reconstruction technique based on the conformal mapping theorem is proposed and investigated in depth in the contribution by H Haddar and R Kress, `Conformal mapping and impedance tomography'. This paper expands on previous work, with inclusions in homogeneous media, convergence results, and numerical illustrations. 8. The contribution by T Hohage and S Langer, `Acceleration techniques for regularized Newton methods applied to electromagnetic inverse medium scattering problems', focuses on a spectral preconditioner intended to accelerate regularized Newton methods as employed for the retrieval of a local inhomogeneity in a three-dimensional vector electromagnetic case, while also illustrating the implementation of a Lepskiĭ-type stopping rule outsmarting a traditional discrepancy principle. 9. Geophysical applications are a rich source of practically relevant inverse problems. The contribution by M Li, A Abubakar and T Habashy, `Application of a two-and-a-half dimensional model-based algorithm to crosswell electromagnetic data inversion', deals with a model-based inversion technique for electromagnetic imaging which addresses novel challenges such as multi-physics inversion, and incorporation of prior knowledge, such as in hydrocarbon recovery. 10. Non-stationary inverse problems, considered as a special class of Bayesian inverse problems, are framed via an orthogonal decomposition representation in the contribution by A Lipponen, A Seppänen and J P Kaipio, `Reduced order estimation of nonstationary flows with electrical impedance tomography'. The goal is to simultaneously estimate, from electrical impedance tomography data, certain characteristics of the Navier--Stokes fluid flow model together with time-varying concentration distribution. 11. Non-iterative imaging methods of thin, penetrable cracks, based on asymptotic expansion of the scattering amplitude and analysis of the multi-static response matrix, are discussed in the contribution by W-K Park, `On the imaging of thin dielectric inclusions buried within a half-space', completing, for a shallow burial case at multiple frequencies, the direct imaging of small obstacles (here, along their transverse dimension), MUSIC and non-MUSIC type indicator functions being used for that purpose. 12. The contribution by R Potthast, `A study on orthogonality sampling' envisages quick localization and shaping of obstacles from (portions of) far-field scattering patterns collected at one or more time-harmonic frequencies, via the simple calculation (and summation) of scalar products between those patterns and a test function. This is numerically exemplified for Neumann/Dirichlet boundary conditions and homogeneous/heterogeneous embedding media. 13. The contribution by J D Shea, P Kosmas, B D Van Veen and S C Hagness, `Contrast-enhanced microwave imaging of breast tumors: a computational study using 3D realistic numerical phantoms', aims at microwave medical imaging, namely the early detection of breast cancer. The use of contrast enhancing agents is discussed in detail and a number of reconstructions in three-dimensional geometry of realistic numerical breast phantoms are presented. 14. The contribution by D A Subbarayappa and V Isakov, `Increasing stability of the continuation for the Maxwell system', discusses enhanced log-type stability results for continuation of solutions of the time-harmonic Maxwell system, adding a fresh chapter to the interesting story of the study of the Cauchy problem for PDE. 15. In their contribution, `Recent developments of a monotonicity imaging method for magnetic induction tomography in the small skin-depth regime', A Tamburrino, S Ventre and G Rubinacci extend the recently developed monotonicity method toward the application of magnetic induction tomography in order to map surface-breaking defects affecting a damaged metal component. 16. The contribution by F Viani, P Rocca, M Benedetti, G Oliveri and A Massa, `Electromagnetic passive localization and tracking of moving targets in a WSN-infrastructured environment', contributes to what could still be seen as a niche problem, yet both useful in terms of applications, e.g., security, and challenging in terms of methodologies and experiments, in particular, in view of the complexity of environments in which this endeavor is to take place and the variability of the wireless sensor networks employed. To conclude, we would like to thank the able and tireless work of Kate Watt and Zoë Crossman, as past and present Publishers of the Journal, on what was definitely a long and exciting journey (sometimes a little discouraging when reports were not arriving, or authors were late, or Guest Editors overwhelmed) that started from a thorough discussion at the `Manchester workshop on electromagnetic inverse problems' held mid-June 2009, between Kate Watt and the Guest Editors. We gratefully acknowledge the fact that W W Symes gave us his full backing to carry out this special issue and that A K Louis completed it successfully. Last, but not least, the staff of Inverse Problems should be thanked, since they work together to make it a premier journal.

BMC Ecology image competition: the winning images

PubMed Central

2013-01-01

BMC Ecology announces the winning entries in its inaugural Ecology Image Competition, open to anyone affiliated with a research institute. The competition, which received more than 200 entries from international researchers at all career levels and a wide variety of scientific disciplines, was looking for striking visual interpretations of ecological processes. In this Editorial, our academic Section Editors and guest judge Dr Yan Wong explain what they found most appealing about their chosen winning entries, and highlight a few of the outstanding images that didn’t quite make it to the top prize. PMID:23517630

The 52nd International Conference on Medicinal Chemistry (RICT 2016) of the French Medicinal Chemistry Society (SCT) Held in Caen (Normandy).

PubMed

Sapi, Janos; Van Hijfte, Luc; Dallemagne, Patrick

2017-06-21

Outstanding Medchem in France: Guest editors Janos Sapi, Luc Van Hjfte, and Patrick Dallemagne look back at the 52 nd International Conference on Medicinal Chemistry (RICT 2016) held in Caen, France. They discuss the history of the French Medicinal Chemistry Society (Société de Chimie Thérapeutique, SCT) and provide highlights of last year's events, including some key presentations now collected in this Special Issue. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

BMC Ecology image competition: the winning images.

PubMed

Harold, Simon; Wong, Yan; Baguette, Michel; Bonsall, Michael B; Clobert, Jean; Royle, Nick J; Settele, Josef

2013-03-22

BMC Ecology announces the winning entries in its inaugural Ecology Image Competition, open to anyone affiliated with a research institute. The competition, which received more than 200 entries from international researchers at all career levels and a wide variety of scientific disciplines, was looking for striking visual interpretations of ecological processes. In this Editorial, our academic Section Editors and guest judge Dr Yan Wong explain what they found most appealing about their chosen winning entries, and highlight a few of the outstanding images that didn't quite make it to the top prize.

Guest Editorial

NASA Astrophysics Data System (ADS)

Saravanan, Padmanapan; Babu, Dhanakotti Rajan; Chelvane, Jeyaramane Arout; Vizhi, Rajasekaran Ezhil

2016-11-01

This special issue of Journal of Magnetism and Magnetic Materials (JMMM) is a collection of selected papers presented at the International Conference on Magnetic Materials and Applications (ICMAGMA-2015), held at VIT University, Vellore, India during December 2 - 4, 2015. The papers were screened and selected for publication after an intensive peer review, with a minimum of two reviewers for every paper. The editors would like to place on record the unstinted support received from over 100 reviewers which culminated in the selection of 49 manuscripts for publication. We take this opportunity to thank everyone for participating in the ICMAGMA-2015.

Editors' message--Hydrogeology Journal in 2003

USGS Publications Warehouse

Voss, Clifford; Olcott, Perry; Schneider, Robert

2004-01-01

Hydrogeology Journal appeared in six issues containing a total of 710 pages and 48 major articles, including 31 Papers and 14 Reports, as well as some Technical Notes and Book Reviews. The number of submitted manuscripts continues to increase. The final issue of 2003 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines and authors in 2003 were from about 28 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on a variety of general topics and on studies of hydrogeology in 24 countries: Afghanistan, Algeria, Argentina, Australia, Bangladesh, Belgium, Canada, Chile, China, Denmark, France, India, Italy, Mexico, Netherlands, New Zealand, Nigeria, Norway, Portugal, Russia, South Africa, Switzerland, Turkey, and U.S.A. The Guest Editor of the 2003 HJ theme issue on “Hydromechanics in Geology and Geotechnics”, Ove Stephansson, assembled a valuable collection of technical reviews and research papers from eminent authors on important aspects of the subject area.

Ambulatory Phlebectomy

MedlinePlus

... of Mitchel Goldman Before and after - IPL - face solar lentigenes, melasma, brown spots Photo courtesy of Mitchel ... Mitchel Goldman Before and after - IPL: face, rosacea, solar lentigenes, and photodamage Photo courtesy of Mitchel Goldman ...

Sustainable Chemistry at Sungkyunkwan University.

PubMed

Park, Nam-Gyu

2015-07-20

Special Issue: Sustainable Chemistry at Sungkyunkwan University. Sustainable chemistry is key to the development of efficient renewable energies, which will become more and more important in order to combat global warming. In this Editorial, guest editor Prof. Nam-Gyu Park describes the context of this Special Issue on top-quality research towards sustainability performed at Sungkyunkwan University (SKKU) in Korea. Scientists at SKKU work on, for example, photovoltaic solar cells to generate low-cost electricity, lithium batteries and capacitors to store electricity, piezoelectric nanogenerators, thermoelectric devices, hydrogen generation, and fuel cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ferroelectrics Volume 121 Numbers 1-4, 1991. Proceedings of the International Conference on Ferroelectric Liquid Crystals (3rd) Held in Boulder, Colorado on 23-28 June 1991. Part 1

DTIC Science & Technology

1992-01-01

they are part of the proceedings of FLC-91. The Guest Editors would like to thank the sponsors, administrative assistants, and especially all of the...the soft mode in comparison to the high frequency permittivi- ty, which results in rather low sensitivity of the method especially far from Tc The...elastomers6 and especially LC-elastomers * 7,8with Se-phases ’ can be prepared by crosslinking of LC-polymers. These polymers show the ferroelectric modes

PREFACE: 6th International Workshop on Multi-Rate Processes and Hysteresis (MURPHYS2012)

NASA Astrophysics Data System (ADS)

Dimian, Mihai; Rachinskii, Dmitrii

2015-02-01

The International Workshop on Multi-Rate Processes and Hysteresis (MURPHYS) conference series focuses on multiple scale systems, singular perturbation problems, phase transitions and hysteresis phenomena occurring in physical, biological, chemical, economical, engineering and information systems. The 6th edition was hosted by Stefan cel Mare University in the city of Suceava located in the beautiful multicultural land of Bukovina, Romania, from May 21 to 24, 2012. This continued the series of biennial multidisciplinary conferences organized in Cork, Ireland from 2002 to 2008 and in Pécs, Hungary in 2010. The MURPHYS 2012 Workshop brought together more than 50 researchers in hysteresis and multi-scale phenomena from the United State of America, the United Kingdom, France, Germany, Italy, Ireland, Czech Republic, Hungary, Greece, Ukraine, and Romania. Participants shared and discussed new developments of analytical techniques and numerical methods along with a variety of their applications in various areas, including material sciences, electrical and electronics engineering, mechanical engineering and civil structures, biological and eco-systems, economics and finance. The Workshop was sponsored by the European Social Fund through Sectoral Operational Program Human Resources 2007-2013 (PRO-DOCT) and Stefan cel Mare University, Suceava. The Organizing Committee was co-chaired by Mihai Dimian from Stefan cel Mare University, Suceava (Romania), Amalia Ivanyi from the University of Pecs (Hungary), and Dmitrii Rachinskii from the University College Cork (Ireland). All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. The Guest Editors wish to place on record their sincere gratitude to Miss Sarah Toms for the assistance she provided during the publication process. More information about the Workshop can be found at http://www.murphys.usv.ro/ Mihai Dimian and Dmitrii Rachinskii Guest Editors for Journal of Physics: Conference Series Proceedings of the 6th International Workshop on Multi-Rate Processes and Hysteresis

John F. Kennedy, Jr., speaks to invited guests at KSC's HBO premiere 'From the Earth to the Moon.'

NASA Technical Reports Server (NTRS)

1998-01-01

John F. Kennedy, Jr., editor-in-chief of George Magazine, greets invited guests at the Home Box Office (HBO) and Imagine Entertainment premiere of the 12-part miniseries 'From the Earth to the Moon' at Kennedy Space Center (KSC). The series was filmed in part on location at KSC and dramatizes the human aspects of NASA's efforts to launch Americans to the Moon. The miniseries highlights NASA's Apollo program and the events leading up to and including the six successful missions to the Moon. A special 500- seat theater was constructed next to the Apollo/Saturn V Center for the KSC premiere showing. Speakers at the event included KSC Director Roy Bridges (at right); Jeff Bewkes, chairman and CEO for HBO; and John F. Kennedy, Jr. Also attending the event, which featured the episode entitled '1968,' were Buzz Aldrin, Apollo 11 astronaut, and Al Worden, Apollo 15 astronaut. The original miniseries event, created for HBO by actor Tom Hanks and Imagine Entertainment, will premiere on HBO beginning April 5, 1998.

PREFACE: 6th International Conference on Inverse Problems in Engineering: Theory and Practice

NASA Astrophysics Data System (ADS)

Bonnet, Marc

2008-07-01

The 6th International Conference on Inverse Problems in Engineering: Theory and Practice (ICIPE 2008) belongs to a successful series of conferences held up to now following a three-year cycle. Previous conferences took place in Palm Coast, Florida, USA (1993), Le Croisic, France (1996), Port Ludlow, Washington, USA (1999), Angra dos Reis, Brazil (2002), and Cambridge, UK (2005). The conference has its roots on the informal seminars organized by Professor J V Beck at Michigan State University, which were initiated in 1987. The organization of this Conference, which took place in Dourdan (Paris) France, 15-19 June 2008, was made possible through a joint effort by four research departments from four different universities: LEMTA (Laboratoire de Mécanique Théorique et Appliquée, Nancy-Université) LMS (Laboratoire de Mécanique des Solides, Ecole Polytechnique, Paris) LMAC (Laboratoire de Mathématiques Appliquées, UTC Compiègne) LTN (Laboratoire de Thermocinétique, Université de Nantes) It received support from three organizations: SFT (Société Française de Thermique: French Heat Transfer Association) ACSM (Association Calcul de Structures et Simulation : Computational Structural Mechanics Association) GdR Ondes - CNRS (`Waves' Network, French National Center for Scientific Research) The objective of the conference was to provide the opportunity for interaction and cross-fertilization between designers of inverse methods and practitioners. The delegates came from very different fields, such as applied mathematics, heat transfer, solid mechanics, tomography.... Consequently the sessions were organised along mostly methodological topics in order to facilitate interaction among participants who might not meet otherwise. The present proceedings, published in the Journal of Physics: Conference Series, gathers the four plenary invited lectures and the full-length versions of 103 presentations. The latter have been reviewed by the scientific committee (see composition below) and additional reviewers we wish to thank here for their kind help. Among the 194 abstracts initially received, 121 communications have been accepted for presentation, 109 of which having been actually presented (oral or poster form) at the conference, as well as 4 invited plenary lectures. The presentations for each session topic, and the geographic distribution of the delegates, are given in tables below. It is our hope that ICIPE 2008 has contributed to maintaining existing interactions and fostering new ones. We take this opportunity to thank all the authors for their valuable contributions and the excellent atmosphere of the meeting. The next ICIPE conference is planned to take place in the USA in May 2010. It will be organized by Alain J Kassab of the University of Central Florida (UCF) in Orlando, and will take place on the UCF campus. Further details regarding ICIPE 2010 conference will be made available on the ICIPE 2008 website during the fall of 2008, and will also be disseminated directly to individuals having attended previous ICIPE meetings. The editorial committee of ICIPE 2008, Marc Bonnet - Guest Editor Stéphane André - Associate guest editor Andrei Constantinescu - Associate guest editor Abdellatif El Badia - Associate guest editor Yvon Jarny - Associate guest editor Denis Maillet - Associate guest editor Scientific Committee: ICIPE 2008 ChairmanM. Bonnet (Ecole Polytech., France) SecretariesS. André (Nancy-U., France) A. Constantinescu (Ecole Polytech., France) Honorary membersO. M. Alifanov (Moscow Aviation Institute, Russia) J. V. Beck (Mich. State U., USA) Members G. Alessandrini (U. Trieste, Italy)R. Kress (U. Goettingen, Germany) J. S. Alves (Inst. Sup. Tecnico, Portugal) S. Kubo (Osaka U., Japan) S. Andrieux (EDF, France) K. J. Langenberg (U. Kassel, Germany) S. Arridge (U. College, London, UK) C. Leniliot (U. Provence, France) M. Azaiez (U. Bordeaux, France) D. Lesnic (U. Leeds, UK) J.-C. Batsale (U. Bordeaux, France) W. Lionheart (U. Manchester, UK) M. Bertero (U. Genova, Italy) D. Maillet (Nancy-U., France) J. Blum (U. Nice, France) W. Marquardt (RWTH Aachen, Germany) H. D. Bui (Ecole Polytech., France) P. A. Martin (Col. School of Mines, USA) T. Burczynski (Silesian Tech. U., Gliwice, Poland) A. Michalak (U. of Michigan, USA) G. Dassios (U. Patras, Greece) A. Nenarokomov (Moscow Aviation Inst., Russia) D. Delaunay (U. Nantes, France) D. Murio (U. Cincinnati, USA) H. Dinh Nho (Hanoi Inst. Maths, Vietnam) A. J. Nowak (Silesian Tech. U. Gliwice, Poland) A. El Badia (U. Tech. Compiègne, France) H. R. B. Orlande (Federal U. Rio de Janeiro, Brazil) J. Frankel (U. Tennessee, USA) L. Päivärinta (U. Helsinki, Finland) O. Ghattas (Carnegie Mellon U., USA) D. Petit (U. Poitiers, France) B. Guzina (U. Minnesota, USA) L. Pronzato (U. Nice, France) A. Hasanov (Kocaeli U., Turkey) M. Prud'homme (Ecole Polytech. Montréal, Canada) F. Hild (ENS Cachan, France) O. Scherzer (U. Innsbruck, Austria) C.-H. Huang (National Cheng Kung U., Taiwan) V. Shutyaev (Inst. Num. Maths, Russia) M. Ikehata (Gunma U., Japan) A. J. Silva Neto (U. Estado Rio de Janeiro, Brazil) M. Jaoua (Ecole Nat. Ingé. Tunis, Tunisia) V. Steffen Jr (U. Federal Uberlandia, Brazil) Y. Jarny (U. Nantes, France) G. Uhlmann (U. Washington, USA) S. Kabanikhin (Sobolev Inst. Maths., Russia) K. A. Woodbury (U. Alabama, USA) J. Kaipio (U. Kuopio, Finland) A. Yagola (Moscow State U., Russia) Kyung Youn Kim (Cheju National U., South Korea) E. Zuazua (U. Complutense Madrid, Spain) Additional Reviewers H. Ammari (ESPCI and Ecole Polytech., France) Y. Favennec (U. Poitiers, France) S. Avril (Ecole Mines St. Etienne, France) O. Fudym (Ecole Mines Albi, France) G. Bal (U. Columbia, USA) M. Girault (U. Poitiers, France) J.-L. Battaglia (U. Bordeaux, France) F. Hemez (Los Alamos Natl. Lab., USA) F. Bauer (Johannes Kepler U., Linz, Austria) M. Janicki (RICAM, Linz, Austria & T.U. Lodz, Poland) C. Bissieux (U. Reims, France) N. Laraqi (U. Paris X, France) F. Ben Belgacem (U. Tech. Compiègne, France) P. Le Masson (U. Bretagne Sud, Lorient, France) L. Bourgeois (ENSTA, Paris, France) D. Lemonnier (U. Poitiers, France) M. Burger (U. Münster, Germany) A. Louis (U. Saarbrücken, Germany) F. Cakoni (U. Delaware, USA) C. Moyne (Nancy-U., France) S. Chaabane (ENIT, Tunisia) B. Rémy (Nancy-U., France) L. Cordier (U. Poitiers, France) J.-J. Serra (DGA, Odeillo, France) A. Degiovanni (Nancy-U., France) D. Stemmelen (Nancy-U., France)

Desert Dust Properties, Modelling, and Monitoring

NASA Technical Reports Server (NTRS)

Kaskaoutis, Dimitris G.; Kahn, Ralph A.; Gupta, Pawan; Jayaraman, Achuthan; Bartzokas, Aristides

2013-01-01

This paper is just the three-page introduction to a Special Issue of Advances in Meteorology focusing on desert dust. It provides a paragraph each on 13 accepted papers, most relating to the used of satellite data to assess attributes or distribution of airborne desert dust. As guest Associate Editors of this issue, we organized the papers into a systematic whole, beginning with large-scale transport and seasonal behavior, then to regional dust transport, transport history, and climate impacts, first in the Mediterranean region, then India and central Asia, and finally focusing on transport model assessment and the use of lidar as a technique to constrain dust spatial-temporal distribution.

Club health: global perspectives, new directions.

PubMed

Measham, Fiona; Anderson, Tammy; Hadfield, Phil

2009-01-01

This editorial presents the views of the guest editors of this collection in summarising some of the general themes arising from a selection of papers presented at the 2008 Club Health Conference in Ibiza, Spain. Particular emphasis is placed upon the value of comparative approaches to club studies, youth culture and substance use so that researchers, policy-makers, and practitioners can gain new understanding of the interplay of local and global factors which shape club cultures, nightlife scenes, and individual lifestyles. By contextualizing the studies in this volume, the editorial outlines important themes and issues which will help promote Club Studies as an interdisciplinary field of endeavour well into the future.

Perovskite Solar Cells and Devices at EPFL Valais Wallis.

PubMed

Nazeeruddin, Mohammad Khaja

2016-09-22

Stability required! Perovskite solar cells have emerged as one of the most exciting fields of research, owing to their impressive rise in power conversion efficiency surpassing 22% in six short years of research. Current research is focused on ways to improve stability of perovskite-based devices, a key characteristic required to bring this technology from the lab into the market. In this Editorial, guest editor Prof. Mohammad Khaja Nazeeruddin describes the context of this Special Issue, and summarizes the work being performed in his research group toward this low-cost near-future photovoltaic technology. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

EDITORIAL: Message from the Editor Message from the Editor

NASA Astrophysics Data System (ADS)

Thomas, Paul

2010-02-01

This year Nuclear Fusion celebrates its fiftieth anniversary. This has been marked by the January special edition, containing papers presented at the plenary and celebratory evening session of the 22nd Fusion Energy Conference at Geneva. These papers underline the enormous progress that has been made in the last 50 years both in experiment and theory. Whilst the technical challenges that we face are still formidable, they are largely concerned with engineering a fusion reactor rather than fundamental plasma physics. In my editorial of a year ago, I remarked on the price of oil and the incentive that it gives to develop nuclear fusion into a viable energy source. This last year, attention has shifted somewhat from the markets to the environment and the Copenhagen climate summit in particular. The timescale for action on the environment is much shorter than we can possibly match and so we can only play our part towards developing long term solutions. Our responsibility is to present a programme that has the clear goal in developing a sustainable source of energy and, as the next step, make an unambiguous success of ITER. The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. The journal depends entirely on its authors and referees and so I would like to thank them all for their work in 2009 and look forward to a continuing, successful collaboration in 2010. Refereeing The Nuclear Fusion Editorial Office understands how much effort is required of our referees. The Editorial Board decided that an expression of thanks to our most loyal referees is appropriate and so, since January 2005, we have been offering the top ten most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. This year, seven of the top referees have reviewed four or more manuscripts in the period November 2008 to November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion award was Steven A. Sabbagh et al for the paper entitled 'Resistive wall stabilized operation in rotating high beta NSTX plasmas' (Nucl. Fusion 46 635-644). Reviews Last year I announced a revival of Nuclear Fusion Reviews, following a decision by the Board of Editors. 'A review of zonal flow experiments', by Akihide Fujisawa was the first fruit of this. In 2010, we are expecting to publish further review articles, the first of which is entitled 'Gyrokinetic simulations of turbulent transport' by Xavier Garbet, Yasuhiro Idomura, Laurent Villard and Tomo-Hiko Watanabe. Letters At the 2009 Board of Editors Meeting in Atlanta, the current letters procedure was summarized and it was noted that the peer review time for Letters is quite variable. Some are accepted within a month of submission, others take longer. Since the purpose of Letters is to provide a route for rapid communication, this is quite an important matter. It was agreed that the Board of Editors would play a more active role in the Letter approval process. If a reviewer asks for a second revision the Editor or a Board of Editors member will be queried as to whether the submission should still be treated as a Letter rather than a regular Paper. The Board of Editors The following Board of Editors members reached the end of their term in 2009: Amanda Hubbard, Yaroslav Kolesnichenko, Kunioki Mima, Boris Sharkov and Michael Ulrickson. On behalf of the Nuclear Fusion Office and the Chairman of the Board of Editors, Mitsuru Kikuchi, I would like to thank them for their efforts in support of the journal. At the same time, we welcomed: Hiroshi Azechi, Xuru Duan, Richard Hawryluk, Sergey Konovalov, Bruce Lipschultz, Peter Norreys, Francesco Romanelli, Tony Taylor and Hartmut Zohm. I am sure that such an illustrious group does not need any introduction to the readers of Nuclear Fusion and I am confident that the new members can only further the success of the journal. It is with great sadness that I have to note the passing away of the following former members of the Board of Editors: Ravindra Sudan (1975 to 1984), Joe Di Marco (1984 to 1991) and Roy Bickerton (1975 to 1986). The Nuclear Fusion Office and IOP Publishing Just as the journal depends on the authors and referees, so its success is also due to the tireless and largely unsung efforts of the Nuclear Fusion Office in Vienna and IOP Publishing in Bristol. I would like to express my personal thanks to Maria Bergamini-Roedler, Katja Haslinger, Sophy Le Masurier, Yasmin McGlashan, Caroline Wilkinson, Sarah Ryder, Rachael Kriefman and Katie Gerrard for the support that they have given to me, the authors and the referees. Season's Greetings The January special edition delayed this editorial for a month. Nevertheless, I would like belatedly to wish our readers, authors, referees and Board of Editors the season's greetings and thank them for their contributions to Nuclear Fusion in 2009.

Mitchell's influence on European studies of peripheral nerve injuries during World War I.

PubMed

Koehler, Peter J; Lanska, Douglas J

2004-12-01

Describe the influence of S. Weir Mitchell's (1829-1914) work, and in particular his ideas on causalgia, on European physicians who treated peripheral nerve injuries during World War I (WWI). During the American Civil War (1861-1865), Mitchell studied peripheral nerve injuries with colleagues George Read Morehouse and William Williams Keen. Three monographs resulted from this work. All were important landmarks in the evolution of knowledge of peripheral nerve injuries. A subsequent occasion to improve knowledge came in WWI. The most important European monographs or series on peripheral nerve injuries from WWI were studied with special interest in references to causalgia and Mitchell's works on peripheral nerve injuries. We included works by Tinel, Athanassio-Benisty, Purves-Stewart & Evans and Carter, Foerster and Oppenheim. Tinel and Athanassio-Benisty provided the most detailed information on peripheral nerve injuries and causalgia and often referred to Mitchell. Both mentioned a possible sympathetic origin. Athanassio-Benisty described tremor and other movement disorders in relation to causalgia. Purves-Stewart and Evans mentioned Mitchell and causalgia in the second edition of their book. They advocated the term "thermalgia." Carter, who had access to data of many cases, concentrated his work on causalgia, referring to Mitchell. Foerster provided data of a great number of peripheral nerve injuries, but did not refer to Mitchell. However, he described the symptoms of causalgia cursorily, applying the term Reflexschmerz (reflexpain). Oppenheim was particularly interested in muscle innervation and referred to Mitchell with respect to hypertrichosis and glossy skin. Oppenheim did not use the term causalgia, although he described the syndrome in some of his patients. It wasn't until around 1920 that German physicians devoted significant attention to causalgia and began using the term. Knowledge of peripheral nerve injuries was greatly advanced during and after WWI. Mitchell's influence was mainly found in the French medical literature, where his findings provided the basis for further research on the origin of causalgia. In England, Mitchell and causalgia were also well-known. We found evidence to suggest that some of the English knowledge came from French physicians. German physicians described the symptoms of causalgia, but did not use the term, nor did they refer to Mitchell. This variation in Mitchell's influence by country probably reflects the fact that Mitchell's Injuries of nerves and their consequences was translated into French but not German.

Transmission in Optically Transparent Core Networks

NASA Astrophysics Data System (ADS)

Kilper, Dan; Jensen, Rich; Petermann, Klaus; Karasek, Miroslav

2007-03-01

Scope of Submission

• Optically transparent system design issues, transmission experiments, and field trials
• Optically transparent network architectures and topologies
• Dispersion management in reconfigurable and mesh systems
• Optically transparent network device and sub-system performance, design, characterization and control, including: amplifiers, transmitters, receivers, switches, add/drop multiplexers
• Transient and fault management
• Physical layer system control
• Monitoring and compensation to support transparency
• Wavelength routing and planning as they relate to physical layer transmission
• Hardware cost and configuration optimization for optically transparent networks

Discipline in Organizations: A Field Study.

DTIC Science & Technology

1982-09-01

with the job and supervisor? In this study we will also investigate discipline from an attributional perspective. Mitchell, Green , & Wood (I%1) hove...representing two major d mr nm stability and locus of control. Mitchell, Green , & Wood (1980 and Green & Mitchell (I0) preent a discussion of the kinds...Attributions to external causes prompt the leader to focus on changing the situation. In addition, Mitchell, Green , & Wood (1981) indicate that if the

Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

PubMed

Storck, Steffen E; Pietrzik, Claus U

2017-12-01

The accumulation of the neurotoxin beta-amyloid (Aβ) is a major hallmark in Alzheimer's disease (AD). Aβ homeostasis in the brain is governed by its production and various clearance mechanisms. Both pathways are influenced by the ubiquitously expressed low-density lipoprotein receptor-related protein 1 (LRP1). In cerebral blood vessels, LRP1 is an important mediator for the rapid removal of Aβ from brain via transport across the blood-brain barrier (BBB). Here, we summarize recent findings on LRP1 function and discuss the targeting of LRP1 as a modulator for AD pathology and drug delivery into the brain.

Controlled vocabularies and ontologies in proteomics: Overview, principles and practice☆

PubMed Central

Mayer, Gerhard; Jones, Andrew R.; Binz, Pierre-Alain; Deutsch, Eric W.; Orchard, Sandra; Montecchi-Palazzi, Luisa; Vizcaíno, Juan Antonio; Hermjakob, Henning; Oveillero, David; Julian, Randall; Stephan, Christian; Meyer, Helmut E.; Eisenacher, Martin

2014-01-01

This paper focuses on the use of controlled vocabularies (CVs) and ontologies especially in the area of proteomics, primarily related to the work of the Proteomics Standards Initiative (PSI). It describes the relevant proteomics standard formats and the ontologies used within them. Software and tools for working with these ontology files are also discussed. The article also examines the “mapping files” used to ensure correct controlled vocabulary terms that are placed within PSI standards and the fulfillment of the MIAPE (Minimum Information about a Proteomics Experiment) requirements. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. PMID:23429179

Violence, health, and the 2030 agenda: Merging evidence and implementation.

PubMed

Lee, Bandy X; Donnelly, Peter D; Cohen, Larry; Garg, Shikha

2016-09-01

The Guest Editors introduce the Special Issue for the Journal of Public Health Policy on violence, health, and the 2030 Agenda. Emphasizing the importance of collaboration between scholars and practitioners, they outline the process of jointly imagining and designing the next generation of violence prevention strategies. They include representative works of members of the World Health Organization (WHO) Violence Prevention Alliance (VPA), including the World Bank, the United States Centers for Disease Control and Prevention, Prevention Institute, the Danish Institute Against Torture, the University of Cambridge Institute of Criminology, the London School of Hygiene and Tropical Medicine Gender Violence and Health Centre, and the Yale University Law and Psychiatry Division, among others.

CALL FOR PAPERS: Special Issue on `Geometric Numerical Integration of Differential Equations'

NASA Astrophysics Data System (ADS)

Quispel, G. R. W.; McLachlan, R. I.

2005-02-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and General entitled `Geometric Numerical Integration of Differential Equations'. This issue should be a repository for high quality original work. We are interested in having the topic interpreted broadly, that is, to include contributions dealing with symplectic or multisymplectic integration; volume-preserving integration; symmetry-preserving integration; integrators that preserve first integrals, Lyapunov functions, or dissipation; exponential integrators; integrators for highly oscillatory systems; Lie-group integrators, etc. Papers on geometric integration of both ODEs and PDEs will be considered, as well as application to molecular-scale integration, celestial mechanics, particle accelerators, fluid flows, population models, epidemiological models and/or any other areas of science. We believe that this issue is timely, and hope that it will stimulate further development of this new and exciting field. The Editorial Board has invited G R W Quispel and R I McLachlan to serve as Guest Editors for the special issue. Their criteria for acceptance of contributions are the following: • The subject of the paper should relate to geometric numerical integration in the sense described above. • Contributions will be refereed and processed according to the usual procedure of the journal. • Papers should be original; reviews of a work published elsewhere will not be accepted. The guidelines for the preparation of contributions are as follows: • The DEADLINE for submission of contributions is 1 September 2005. This deadline will allow the special issue to appear in late 2005 or early 2006. • There is a strict page limit of 16 printed pages (approximately 9600 words) per contribution. For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on publishing your work in Journal of Physics A: Mathematical and General may be found at www.iop.org/Journals/jphysa. • Contributions to the special issue should if possible be submitted electronically by web upload at {www.iop.org/Journals/jphysa or by e-mail to jphysa@iop.org, quoting `JPhysA Special Issue—Geometric Integration'. Submissions should ideally be in standard LaTeX form; we are, however, able to accept most formats including Microsoft Word. Please see the web site for further information on electronic submissions. • Authors unable to submit electronically may send hard copy contributions to: Publishing Administrators, Journal of Physics A, Institute of Physics Publishing, Dirac House, Temple Back, Bristol BS1 6BE, UK, enclosing the electronic code on floppy disk if available and quoting `JPhysA Special Issue—Geometric Integration'. • All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. This special issue will be published in the paper and online version of the journal. The corresponding author of each contribution will receive a complimentary copy of the issue. G R W Quispel and R I McLachlan Guest Editors

Guest editors' introduction to the special section on information technology and evidence implementation.

PubMed

Abernethy, Amy P; Hesse, Bradford W

2011-03-01

Healthcare is experiencing a transformation-perhaps as significant as the publication of the first randomized controlled trial-in the ways in which basic discovery is translated into effective practice. The change is being precipitated by efforts to undergird the healthcare industry with the same transformational capacities from information technology as is afforded to other sectors in the economy. Although the transformation has been slow in materializing, change is expected to accelerate under the stimulating influence of the Health Information Technology for Economic and Clinical Health Act of 2009 and the Patient Protection and Affordable Care Act of 2010. As the changes ripple throughout the healthcare sector, two aspects of medical care in the twenty-first century are expected to rise in importance: data and behavior. Each of the articles within this inaugural issue of Translational Behavioral Medicine has been selected to illustrate treatment of these two assets in one way or another. The editors hope this first issue will serve as a vanguard illustration for how behavioral scientists can be included as integral members of the design team in creating a new platform for evidence implementation in the USA and abroad.

The neurologic content of S. Weir Mitchell's fiction.

PubMed

Louis, Elan D; Horn, Stacy; Roth, Lisa Anne

2006-02-14

Silas Weir Mitchell (1829 to 1914), one of the most important neurologists in American Medicine, was known for his seminal work on the phantom limb syndrome, causalgia, and nerve injuries. He was also a prolific writer of novels and short stories. The neurologic content of this fiction has not been studied. To assess the extent that references to neurologic topics were present in Mitchell's fiction, whether these neurologic references reflected Mitchell's scientific interests and contributions, and whether his fictional accounts of neurologic topics would precede those in his scientific writings. The authors read Silas Weir Mitchell's novels and short stories. Seventeen (63.0%) of 27 fictional works contained neurologic references. Fifty-five (69.6%) of 79 references were brief (a single word or sentence). In two works, a neurologic theme was central to the plot. Some of the neurologic content was sophisticated (aphasia, brain laterality). Phantom limb syndrome, causalgia, and nerve injuries were not prominent in his fiction. Neurologic consequences of battle injuries were featured in 10 (37.0%) works. With the exception of "The Case of George Dedlow" (i.e., phantom limb syndrome), Mitchell's fictional accounts of neurologic topics followed his presentation of these topics in the scientific literature. The majority of Mitchell's fictional works contained references to neurologic topics but most contained brief references. The number of references to Mitchell's specific scientific interests (phantom limb syndrome, causalgia) was small, although more generally, references to the neurology of battle injuries occurred more frequently.

Who Was Lucy Sprague Mitchell...And Why Should You Know?

ERIC Educational Resources Information Center

Smith, Mary K.

2000-01-01

Recounts the life and accomplishments of educator and writer Lucy Sprague Mitchell, suggesting that her life can bring inspiration and renewed vigor to today's early childhood educators. Considers the social conditions of Mitchell's era, her formative years, formal education and career decisions, participation in the Progressive Movement and…

1. LOOKING DOWNSTREAM (NORTHEAST) ALONG WINTER'S RUN TOWARD THE MITCHELL'S ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. LOOKING DOWNSTREAM (NORTHEAST) ALONG WINTER'S RUN TOWARD THE MITCHELL'S MILL BRIDGE, SHOWING THE SETTING OF THE BRIDGE. CARRS MILL ROAD APPROACHES THE BRIDGE FROM THE SOUTH, ON THE RIGHT. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

Installation Restoration Program (IRP) Site Investigation Report for IRP Site Number 4. Volume 3. Appendices D-I. 128th Air Refueling Wing, Wisconsin Air National Guard, General Billy Mitchell Field Air National Guard Base, Milwaukee, Wisconsin.

DTIC Science & Technology

1996-03-01

NATIONAL GUARD GENERAL BILLY MITCHELL FIELD AIR NATIONAL GUARD BASE MILWAUKEE, WISCONSIN MARCH 1996 ______ 19960509 134 HQ ANG/CEVR ANDREWS AFB...Report for IRP Site No. 4, Wisconsin Air National Guard, 128th Air Refueling Wing, General Billy Mitchell Field, Milwaukee, Wisconsin - Volume III...Wisconsin Air National Guard, 128th Air Refueling Wing, General Billy Mitchell Field, Milwaukee, Wisconsin, Volume III - Appendices D-I. This is the

Astronaut Edgar D. Mitchell, Apollo 14 Lunar Module pilot

NASA Technical Reports Server (NTRS)

1970-01-01

Portrait of Astronaut Edgar D. Mitchell, Apollo 14 lunar landing mission Lunar Module pilot in civilian clothes. Left to right, are Astronauts Edgar D. Mitchell, lunar module pilot; Stuart A. Roosa, command module pilot; and Alan B. Shepard Jr., commander. They are standing by a Command Module Trainer which was used in the exercise.

The Rhetoric of Richard Mitchell: Is Literacy a Moral Condition?

ERIC Educational Resources Information Center

Kearns, Richard; Bannister, Linda

Richard Mitchell, the "Underground Grammarian," has been dismissed by many in the academic community as a pop-culture grammar-basher. This is unfortunate, since Mitchell has linked literacy to the capacity for moral behavior. This connection between moral capacity and literacy is often avoided by the way in which literacy is defined. In…

Astronaut Edgar Mitchell addresses MSC personnel and news media

NASA Technical Reports Server (NTRS)

1971-01-01

Astronaut Edgar D. Mitchell, right, the Apollo 14 lunar module pilot, addresses JSC/MSC personnel and news media representatives and other visitors soon after he and his fellow crewmen were released from a 15-day confinement period in the Lunar Receiving Laboratory. Pictured with Mitchell in front of the LRL, MSC bldg 37, are Astronauts Alan B. Shepard Jr., left, commander; and Stuart A Roosa, command module pilot, Mrs Mitchell is at right and Mrs. Roosa, near left. Roosa is flanked by his four children, left to right, Christopher A., Stuart A. Roosa Jr., John D. and Rosemary D.

Editorial.

PubMed

Simeonov, Plamen L; Rosen, Steven M; Gare, Arran; Noble, Denis

2015-12-01

Preparing this ambitious Special Issue has challenged everyone involved: authors, reviewers, and guest editors. The editors solicited contributions from many leading figures in a broad array of scientific and philosophical disciplines, with emphasis on phenomenological approaches to philosophy (see Section I). The motivating force was the conviction that if we could find a viable bridge for the gap between the "two cultures"(1) of science and philosophy, fundamental problems in each camp could be addressed more fruitfully than ever before and a new kind of science be born. We believe the unprecedented cross-fertilization of ideas from this initiative may furnish seeds from which that new, better integrated, and more effective approach to science may arise. This Special Issue consists of forty papers. For each one, multiple reviewers were solicited, with at least one reviewer from each "culture" (a scientist and a philosopher). In many cases, several rounds of revision were carried out. Needless to say, this required great patience and dedication of all participants. The editors gratefully acknowledge the contributions of our authors, and of our anonymous reviewers, who worked long and hard on the papers we sent them with no compensation for their efforts. We also wish to thank the Elsevier editorial and production team for the support they gave us in bringing this project to fruition. We would now like to offer a synoptic overview of the Special Issue, proceeding section by section and paper by paper. Our hope is that the reader will find this unique effort to marry science and philosophy both meaningful and enjoyable. Copyright © 2015. Published by Elsevier Ltd.

Silas Weir Mitchell on epilepsy therapy in the late 19th to early 20th centuries.

PubMed

Burkholder, David B; Boes, Christopher J

2014-11-01

Silas Weir Mitchell (1829-1914), one of the fathers of American neurology, is well known for many contributions to neurology. However, his efforts in epilepsy are overshadowed by his other accomplishments. Mitchell introduced a new bromide preparation, lithium bromide, as a viable therapy. His most widely accepted contribution to the field was the introduction of inhaled amyl nitrite for early termination of seizures accompanied by an appropriate aura. Despite the prevalent views on lifestyle modification as a treatment for epilepsy during this time period, as well as Mitchell's own development of the "rest cure" for certain disease states, he was not a proponent of these types of interventions for epilepsy, nor did he support interventions focused on other organ systems, such as abdominal or gynecologic surgery. Mitchell had distinct opinions on the treatment of epilepsy, and helped to advance its therapeutics during his career.

Fish-eye lens view Astronauts Shepard and Mitchell in Lunar Module Simulator

NASA Image and Video Library

1970-07-15

S70-45555 (July 1970) --- A fish-eye lens view showing astronauts Alan B. Shepard Jr. (foreground) and Edgar D. Mitchell in the Apollo lunar module mission simulator at the Kennedy Space Center during preflight training for the Apollo 14 lunar landing mission. Shepard is the Apollo 14 commander; and Mitchell is the lunar module pilot.

Mission for Mitchell

NASA Astrophysics Data System (ADS)

Carlowicz, Michael

In honor of a life of pioneering efforts to use satellite altimetry for geophysical studies, the U.S. Navy announced on December 16, 1996, that it will dedicate its next satellite altimeter—the follow-on to Geosat—to deceased AGU member Jimmy Mitchell. The announcement was made during a special session dedicated to Mitchell's research at the AGU Fall Meeting.Mitchell first won renown at the Jet Propulsion Laboratory in the 1970s and 1980s while conducting research associated with Voyager missions. But it was his work in later years at the Naval Research Laboratory at Stennis Space Center, Mississippi, that led the Navy to honor him with the satellite.

Special Section: ;Microbial fuel cells: From fundamentals to applications;: Guest Editors' note

NASA Astrophysics Data System (ADS)

Santoro, Carlo; Arbizzani, Catia; Erable, Benjamin; Ieropoulos, Ioannis

2017-07-01

Water scarcity and production of non-renewable energy are among the most serious challenges faced by humankind at present. Water-related problems such as insufficient freshwater for drinking or irrigation or, even worse, unavailability of freshwater exist in many parts of the world. Over a billion people lack access to clean water, and approximately two million people die every year because of inadequate water sanitation. Fossil fuel combustion has also become problematic because of the depletion of fossil fuels, which are finite energy sources. This together with the emissions of greenhouse gases has increased the CO2 concentration in atmosphere to an unprecedented level of >400 ppm. Therefore, it is of paramount importance to identify new renewable energy sources and more efficient ways of energy consumption and hybridization with existing technologies.

CALL FOR PAPERS: Special Issue on `Singular Interactions in Quantum Mechanics: Solvable Models'

NASA Astrophysics Data System (ADS)

Dell'Antonio, G.; Exner, P.; Geyler, V.

2004-07-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and General entitled `Singular Interactions in Quantum Mechanics: Solvable Models'. This issue should be a repository for high quality original work. We are interested in having the topic interpreted broadly, that is, to include contributions dealing with point-interaction models, one- and many-body, quantum graphs, including graph-like structures coupling different dimensions, interactions supported by curves, manifolds, and more complicated sets, random and nonlinear couplings, etc., as well as approximations helping us to understand the meaning of singular couplings and applications of such models on different parts of quantum mechanics. We believe that when the second printing of the `bible' of the field, the book Solvable Models in Quantum Mechanics by S Albeverio, F Gesztesy, the late R Høegh-Krohn and H Holden, appears it is the right moment to review new developments in this area, with the hope of stimulating further development of these extremely useful techniques. The Editorial Board has invited G Dell'Antonio, P Exner and V Geyler to serve as Guest Editors for the special issue. Their criteria for acceptance of contributions are as follows: bullet The subject of the paper should relate to singular interactions in quantum mechanics in the sense described above. bullet Contributions will be refereed and processed according to the usual procedure of the journal. bullet Papers should be original; reviews of a work published elsewhere will not be accepted. The guidelines for the preparation of contributions are as follows: bullet The DEADLINE for submission of contributions is 31 October 2004. This deadline will allow the special issue to appear in about April 2005. bullet There is a nominal page limit of 15 printed pages (approximately 9000 words) per contribution. Papers exceeding these limits may be accepted at the discretion of the Guest Editors. Further advice on publishing your work in Journal of Physics A: Mathematical and General may be found at www.iop.org/Journals/jphysa. bullet Contributions to the Special Issue should if possible be submitted electronically by web upload at {www.iop.org/Journals/jphysa or by e-mail to jphysa@iop.org, quoting `JPhysA Special Issue-Quantum Mechanics: Solvable Models'. Submissions should ideally be in standard LaTeX form; we are, however, able to accept most formats including Microsoft Word. Please see the web site for further information on electronic submissions. bullet Authors unable to submit electronically may send hard copy contributions to: Publishing Administrators, Journal of Physics A, Institute of Physics Publishing, Dirac House, Temple Back, Bristol BS1 6BE, UK, enclosing the electronic code on floppy disk if available and quoting `JPhysA Special Issue-Quantum Mechanics: Solvable Models'. bullet All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. This special issue will be published in the paper and online version of the journal. The corresponding author of each contribution will receive a complimentary copy of the issue. G Dell'Antonio, P Exner and V Geyler Guest Editors

PREFACE: 14th General Conference of the Condensed Matter Division

NASA Astrophysics Data System (ADS)

de Segovia, José L.; Flores, F.; García-Moliner, F.

1994-01-01

This volume contains the proceedings of the 14th General Conference of the Condensed Matter Division, GCCMD-14, held on 28-31 March 1994, at the Faculty of Civil Engineering of the Polytechnical University of Madrid. The publication contains the Plenary and Invited Lectures of those authors who agreed to publish their presentations. The meeting was organized by the Spanish Vacuum Society, ASEVA, under the auspices of the Condensed Matter Division of the European Physical Society, CMD-EPS. The Conference was attended by 466 participants mostly from Europe. The emphasis of the Conference was mainly on: Semiconductors and Insulators Surfaces and Interfaces Liquids and Statistical Mechanics Magnetism and Metals Macromolecules and Chemical Physics The 554 contributions were presented as 6 plenary lectures, 67 invited lectures, 140 oral presentation and 341 poster presentation, in five parallel sessions. The guest Editors are grateful to those authors who sent their contribution for the publication, to the Organizing Committee, to the International Advisory and Programme Committee and to the Local Committee for their excellent work. We also wish to thank those colleagues who took on the hard task of helping in refereeing the papers. It is also a pleasure to thank the Physica Scripta Editor and Editorial Board of Physica Scripta.

Maria Mitchell: A New Scholarly Biography

NASA Astrophysics Data System (ADS)

Welther, Barbara L.

2007-12-01

Margaret Moore Booker has researched, written, and just published a proper biography of "America's First Woman Astronomer." To the diaries, notes, and lectures that Maria Mitchell wrote, Booker has added details from other historical sources and pulled together a very stylish, well-written, and illuminating volume. This paper will review some of the well-known details of Mitchell's life and show how Booker's work sheds new light on her subject's persona.

Healthcare reform in the Middle East and the USA.

PubMed

Younis, Mustafa Z

2017-01-01

Mustafa Z Younis speaks to Laura Dormer, Commissioning Editor: Dr Mustafa Z Younis is an internationally recognized scholar and was a member of the Executive Committee of the International Society for Research of Healthcare Financial Management. Dr Younis has authored and published over 200 articles, abstracts and presentations in refereed journals and meetings, and has presented at national and international conferences. Dr Younis has administrative experience as Senior Adviser for the President at Zirve University, Turkey and as Chair of the Department of Health Policy and Management at Florida International University (FL, USA) where he led the accreditation efforts for the Healthcare Management Program. Dr Younis has a history of playing visible roles on the editorial boards of journals as Chief Editor, Guest Editor and Editorial board member of leading journals such as Journal of International Medical Research, Journal of Health Care Finance, Inquiry, Journal of Health and Human Services Administration, Journal of Public Budgeting, Accounting and Financial Management. Dr Younis is a frequent speaker for both academic and professional audiences. His talks often feature his latest research and work in progress as well as cross-industry trends and strategy implications. He has provided workshops and presentation for wide organizations. His research and findings applied to for-profit, non-profit settings, and government. Dr Younis has consulted with several organizations on healthcare finance, and economics. Dr Younis is often invited to speak about the challenges in the healthcare industry and other related topics to health economics, finance, and research. He has presented topics such as, healthcare reform, ownership structure, profitability, unit cost, payment system and efficiency in management, at a variety of forums and conferences in Europe, Asia and Middle East.

Rediscovering Vygotsky's Concept of the ZPD: Stanley Mitchell's New Translation of "The Problem of Teaching ['Obuchenie'] and Mental Development at School Age"

ERIC Educational Resources Information Center

Barrs, Myra

2017-01-01

This article introduces the new translation by Stanley Mitchell of a very well-known Vygotskyan text, which has become the locus classicus for Vygotsky's concept of the "zone of proximal development" (ZPD). It outlines the history of Vygotsky's text and compares Mitchell's new translation with the version found in Chapter 6 of "Mind…

Apollo 14 Mission image - View of Astronaut Mitchell and the Modular Equipment Transporter with the Lunar Module in background.

NASA Image and Video Library

1971-02-06

AS14-64-9140 (6 Feb. 1971) --- Astronaut Edgar D. Mitchell, lunar module pilot, participates in the mission's second extravehicular activity (EVA). He is standing near the modularized equipment transporter (MET). While astronauts Alan B. Shepard Jr., commander, and Mitchell descended in the Apollo 14 LM to explore the moon, astronaut Stuart A. Roosa, command module pilot, remained with the Command and Service Modules (CSM) in lunar orbit.

Chevron versus Mitchell osteotomy in hallux valgus surgery: a comparative study.

PubMed

Lambers Heerspink, F O; Verburg, H; Reininga, I H F; van Raaij, T M

2015-01-01

Good clinical results have been reported for chevron and Mitchell osteotomies in mild hallux valgus (HV). The primary aim of the present study was to compare first metatarsal shortening after chevron and Mitchell osteotomies in HV. The secondary outcome measures were the degree of valgus correction, metatarsalgia, and patient satisfaction. A total of 84 patients were included in the present study and were treated from 2005 to 2007; 42 patients were in each group. The outcome measurements-first metatarsal length, HV angle, 1-2 intermetatarsal angle, satisfaction, and metatarsalgia-were taken preoperatively and at follow-up. The Mitchell osteotomy resulted in a significantly larger decrease in the first metatarsal length. No significant difference in transfer metatarsalgia was found. Approximately 30% of patients were mildly or not satisfied after HV surgery. Mitchell osteotomy leads to a larger decrease in the first metatarsal length. Patients with metatarsalgia performed poorly, and no significant differences in metatarsalgia were found. Preventing postoperative metatarsalgia is important for a successful outcome after HV surgery. Copyright © 2015 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

Computer vision for RGB-D sensors: Kinect and its applications.

PubMed

Shao, Ling; Han, Jungong; Xu, Dong; Shotton, Jamie

2013-10-01

Kinect sensor, high-resolution depth and visual (RGB) sensing has become available for widespread use as an off-the-shelf technology. This special issue is specifically dedicated to new algorithms and/or new applications based on the Kinect (or similar RGB-D) sensors. In total, we received over ninety submissions from more than twenty countries all around the world. The submissions cover a wide range of areas including object and scene classification, 3-D pose estimation, visual tracking, data fusion, human action/activity recognition, 3-D reconstruction, mobile robotics, and so on. After two rounds of review by at least two (mostly three) expert reviewers for each paper, the Guest Editors have selected twelve high-quality papers to be included in this highly popular special issue. The papers that comprise this issue are briefly summarized.

50 years of comparative biochemistry: The legacy of Peter Hochachka.

PubMed

Buck, L T; Burness, G; Campbell, K L; Darveau, C-A; Driedzic, W; Guderley, H; McClelland, G B; Moon, T W; Moyes, C D; Schulte, P M

2018-02-28

Peter Hochachka was an early pioneer in the field of comparative biochemistry. He passed away in 2002 after 4 decades of research in the discipline. To celebrate his contributions and to coincide with what would have been his 80th birthday, a group of his former students organized a symposium that ran as a satellite to the 2017 Canadian Society of Zoologists annual meeting in Winnipeg, Manitoba (Canada). This Special Issue of CBP brings together manuscripts from symposium attendees and other authors who recognize the role Peter played in the evolution of the discipline. In this article, the symposium organizers and guest editors look back on his career, celebrating his many contributions to research, acknowledging his role in training of generations of graduate students and post-doctoral fellows in comparative biochemistry and physiology. Copyright © 2018. Published by Elsevier Inc.

Hydrogeology Journal in 2002

USGS Publications Warehouse

Olcott, Perry; Schneider, Robert; Voss, Clifford

2003-01-01

Hydrogeology Journal appeared in six issues containing a total of 674 pages and 47 major articles, including 22 Papers and 24 Reports, as well as Technical Notes and Book Reviews. The final issue of 2002 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines. Authors in 2002 were from about 30 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on 22 countries: Afghanistan, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, India, Israel, Japan, Jordan, Mexico, New Zealand, Nigeria, Portugal, Qatar, Switzerland, Syria, Turkey, UK, and the USA. The Guest Editors of the 2002 HJ theme issue on "Groundwater Recharge", Bridget R. Scanlon and Peter G. Cook, assembled a highly relevant and sought-after collection of papers from eminent authors on wide-ranging aspects of the subject.

Air Force UAVs: The Secret History

DTIC Science & Technology

2010-07-01

iA Mitchell Institute Study i Air Force UAVs The Secret History A Mitchell Institute Study July 2010 By Thomas P. Ehrhard Report Documentation Page...DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Air Force UAVs The Secret History 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...opening phases of Operation Enduring Freedom in Afghanistan. By Thomas P. Ehrhard a miTchEll insTiTuTE sTudy July 2010 Air Force UAVs The Secret History

New synonymies in the bee genus Nomada from North America (Hymenoptera: Apidae)

USGS Publications Warehouse

Droege, S.; Rightmyer, M.G.; Sheffield, C.S.; Brady, S.G.

2010-01-01

We provide diagnostic morphological characters to help distinguish males and females of the following species of Nomada: N. augustiana Mitchell, N. bethunei Cockerell, N. fervida Smith, N. fragariae Mitchell, N. lehighensis Cockerell, N. texana Cresson, and N. tiftonensis Cockerell. Based on morphological and DNA barcoding evidence we newly synonymize the following species: N. heligbrodtii Cresson (under N. texana), N. indusata Mitchell (under N. augustiana), N. kingstonensis Mitchell (under N. lehighensis), N. pseudops Cockerell (under N. bethunei), and N. wisconsinensis Graenicher (under N. fervida). We provide full descriptions of the female of N. fragariae and the male of N. lehighensis, both of which were not previously known, and newly designate the lectotype of N. wisconsinensis. We additionally provide comments on the distribution, flight times, and host associations for the treated species. Copyright ?? 2010.

Chemistry without bo(a)rders.

PubMed

Tanzer, Eva-Maria

2014-08-01

Note from the Editor: Science, collegiality, travel without borders. Big smiles and warmth. Eternally youthful vigor. When I think of Tetsuo Nozoe, these are the images that immediately come to mind. When I think of the Nozoe Autograph Books, I also think of time. For 40 years, Nozoe carried with him his autograph books and collected his treasures which The Chemical Record is now publishing. Vladimir Prelog signed first when he was 47 and signed last when he was almost 80. Derek Barton signed first when he was 35 and signed last when he was almost 70. Time! I was fascinated by Eva Wille's recommendation that we publish an essay by Eva-Maria Tanzer, a young organic chemist with already a lifetime's experience in exploring chemical research in laboratories around the world. Tanzer brings to us a charming, even innocent perspective that embraces so much of Tetsuo Nozoe's ideals. We are privileged to include Tanzer's vision and her experiences in the collection of essays that accompany the Nozoe Autograph Books. Our contributors range in age and experiences, from the youthful Tanzer to the more mature (including myself!) as do the signatories in the autograph books. Tetsuo Nozoe would have beamed!--Jeffrey I. Seeman Guest Editor University of Richmond Richmond, Virginia 23173, USA E-mail: jseeman@richmond.edu. Copyright © 2014 The Chemical Society of Japan and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

15. Historic American Buildings Survey W. N. Manning, Photographer, July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Historic American Buildings Survey W. N. Manning, Photographer, July 18, 1935 TOMB MONUMENT OF COL. JOHN CROWELL, SR. AT FORT MITCHELL, ALABAMA - Crowell-Cantey-Alexander House, State Road 165, Fort Mitchell, Russell County, AL

4. APPROACH OF CARRS MILL ROAD TO THE SOUTH PORTAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. APPROACH OF CARRS MILL ROAD TO THE SOUTH PORTAL OF THE MITCHELLS MILL BRIDGE; VIEW TO NORTH. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

Biophysical Aspects of Alzheimer's Disease: Implications for Pharmaceutical Sciences : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

PubMed

Arosio, Paolo

2017-12-01

An increasing amount of findings suggests that the aggregation of soluble peptides and proteins into amyloid fibrils is a relevant upstream process in the complex cascade of events leading to the pathology of Alzheimer's disease and several other neurodegenerative disorders. Nevertheless, several aspects of the correlation between the aggregation process and the onset and development of the pathology remain largely elusive. In this context, biophysical and biochemical studies in test tubes have proven extremely powerful in providing quantitative information about the structure and the reactivity of amyloids at the molecular level. In this review we use selected recent examples to illustrate the importance of such biophysical research to complement phenomenological studies based on cellular and molecular biology, and we discuss the implications for pharmaceutical applications associated with Alzheimer's disease and other neurodegenerative disorders in both academic and industrial contexts.

Notes from the guest editor.

PubMed

Dewa, Carolyn S

2011-01-01

In 2009, four institutes of the Canadian Institutes of Health Research (Gender and Health; Health Services and Policy Research; Neurosciences, Mental Health and Addiction; and Population and Public Health) sponsored the Fourth Annual Canadian Research Congress on Mental Health and Addictions in the Workplace, in Toronto, Ontario. Hosted by the Work and Well-Being Research and Evaluation Program at the Centre for Addiction and Mental Health, the theme of the congress was We Can Do It! Evidence and Interventions for Transforming Mental Health in the Workplace (see http://www.kewa.camh.net/researchers/areas/work_wellbeing/Pages/default.aspx for more details). Coincidentally, in the same year, an idealistic presidential hopeful named Barack Obama adopted a similar slogan for his White House run. Obama recognized that change that challenges established barriers can only come about through co-operation and a collective investment. Copyright © 2011 Longwoods Publishing.

An expanded genetic code for probing the role of electrostatics in enzyme catalysis by vibrational Stark spectroscopy.

PubMed

Völler, Jan-Stefan; Biava, Hernan; Hildebrandt, Peter; Budisa, Nediljko

2017-11-01

To find experimental validation for electrostatic interactions essential for catalytic reactions represents a challenge due to practical limitations in assessing electric fields within protein structures. This review examines the applications of non-canonical amino acids (ncAAs) as genetically encoded probes for studying the role of electrostatic interactions in enzyme catalysis. ncAAs constitute sensitive spectroscopic probes to detect local electric fields by exploiting the vibrational Stark effect (VSE) and thus have the potential to map the protein electrostatics. Mapping the electrostatics in proteins will improve our understanding of natural catalytic processes and, in beyond, will be helpful for biocatalyst engineering. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

Genetic incorporation of Nε-acetyllysine reveals a novel acetylation-sumoylation switch in yeast.

PubMed

Kim, Sang-Woo; Lee, Kyung Jin; Kim, Sinil; Kim, Jihyo; Cho, Kyukwang; Ro, Hyeon-Su; Park, Hee-Sung

2017-11-01

The lysine acetylation of proteins plays a key role in regulating protein functions, thereby controlling a wide range of cellular processes. Despite the prevalence and significance of lysine acetylation in eukaryotes, however, its systematic study has been challenged by the technical limitations of conventional approaches for selective lysine acetylation in vivo. Here, we report the in vivo study of lysine acetylation via the genetic incorporation of N ε -acetyllysine in yeast. We demonstrate that a newly discovered acetylation-sumoylation switch precisely controls the localization and cellular function of the yeast septin protein, Cdc11, during the cell cycle. This approach should facilitate the comprehensive in vivo study of lysine acetylation across a wide range of proteins in eukaryotic organisms. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

Effects of coating spherical iron oxide nanoparticles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milosevic, Irena; Motte, Laurence; Aoun, Bachir

2017-01-01

We investigate the effect of several coatings applied in biomedical applications to iron oxide nanoparticles on the size, structure and composition of the particles. The four structural techniques employed - TEM, DLS, VSM, SAXS and EXAFS - show no significant effects of the coatings on the spherical shape of the bare nanoparticles, the average sizes or the local order around the Fe atoms. The NPs coated with hydroxylmethylene bisphosphonate or catechol have a lower proportion of magnetite than the bare and citrated ones, raising the question whether the former are responsible for increasing the valence state of the oxide onmore » the NP surfaces and lowering the overall proportion of magnetite in the particles. VSM measurements show that these two coatings lead to a slightly higher saturation magnetization than the citrate. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazu and Dr. Federica Migliardo.« less

Television transmission at end of second extravehicular activity

NASA Technical Reports Server (NTRS)

1971-01-01

Astronaut Edgar D. Mitchell, Apollo 14 lunar module pilot, can be seen throwing a 'javelin' left handed during a television transmission near the close of the second extravehicular activity (EVA-2) at the Apollo 14 Fra Mauro landing site. Mitchell used the staff of the Solar Wind Composition experiment as the 'javelin'. Behind Mitchell is Astronaut Alan B. Shepard Jr., commander. Also visible in the picture are the erectable S-Band antenna (left foreground) and Lunar Module (left background) (20783); Shepard can be seen preparing to swing at a golf ball during television transmission at end of EVA-2 (20784).

CALL FOR PAPERS: Optics and squeeze transformations after Einstein

NASA Astrophysics Data System (ADS)

Kim, Young S.; Man'ko, Margarita A.; Planat, Michel

2005-01-01

Journal of Optics B: Quantum and Semiclassical Optics will publish a special issue in connection with the 9th International Conference on Squeezed States and Uncertainty Relations, to be held in Besançon, France, on 2-6 May 2005. In 2005, the physics community celebrates the 100th anniversary of the publication of Einstein’s theories of relativity and quantum physics. To celebrate these great contributions to physics, the conference will include sessions on Einstein’s influence on modern optics and the foundations of quantum mechanics. Conference participants, as well as other researchers working in the field, are invited to submit research papers to this special issue of the journal. The topics to be covered include: • Superposition principle • Squeezed states • Uncertainty relations • Quantum state generation and characterization • Phase space and group representations in quantum physics • Quantum transforms in signal analysis • Information theory and quantum computing • Quantum interference, decoherence and entanglement measure • Quantum chaos and quantum control • Bell inequalities • Nonstationary Casimir effect • Quantum-like and mesoscopic systems Manuscripts should be submitted by 1 August 2005 as the special issue is scheduled for publication in March 2006. All papers will be peer reviewed and the normal refereeing standards of Journal of Optics B: Quantum and Semiclassical Optics will be maintained. The Editorial Division of IOP Publishing at the P N Lebedev Physical Institute in Moscow will oversee editorial procedures in association with the IOP Publishing office in Bristol. There are no page charges for publication. Submissions should preferably be in either standard LaTeX form or Microsoft Word. Advice on publishing your work in the journal, including specific information on figures, tables and references, may be found at www.iop.org/journals/authors. Manuscripts should be submitted by e-mail to the Guest Editors at IOPP@sci.lebedev.ru quoting the reference 'Special Issue/ST'. Authors are strongly encouraged to submit their work as soon as possible. Any subsequent change of address should be notified to the publishing office. If you have any questions, please do not hesitate to contact Claire Bedrock, Publisher (claire.bedrock@iop.org) or Margarita A Man'ko, Guest Editor (mmanko@sci.lebedev.ru). For further information on the journal, please visit our Website at www.iop.org/journals/jopb.

CALL FOR PAPERS: Optics and squeeze transformations after Einstein

NASA Astrophysics Data System (ADS)

Kim, Young S.; Man'ko, Margarita A.; Planat, Michel

2004-12-01

Journal of Optics B: Quantum and Semiclassical Optics will publish a special issue in connection with the 9th International Conference on Squeezed States and Uncertainty Relations, to be held in Besançon, France, on 2-6 May 2005. In 2005, the physics community celebrates the 100th anniversary of the publication of Einstein’s theories of relativity and quantum physics. To celebrate these great contributions to physics, the conference will include sessions on Einstein’s influence on modern optics and the foundations of quantum mechanics. Conference participants, as well as other researchers working in the field, are invited to submit research papers to this special issue of the journal. The topics to be covered include: • Superposition principle • Squeezed states • Uncertainty relations • Quantum state generation and characterization • Phase space and group representations in quantum physics • Quantum transforms in signal analysis • Information theory and quantum computing • Quantum interference, decoherence and entanglement measure • Quantum chaos and quantum control • Bell inequalities • Nonstationary Casimir effect • Quantum-like and mesoscopic systems Manuscripts should be submitted by 1 August 2005 as the special issue is scheduled for publication in March 2006. All papers will be peer reviewed and the normal refereeing standards of Journal of Optics B: Quantum and Semiclassical Optics will be maintained. The Editorial Division of IOP Publishing at the P N Lebedev Physical Institute in Moscow will oversee editorial procedures in association with the IOP Publishing office in Bristol. There are no page charges for publication. Submissions should preferably be in either standard LaTeX form or Microsoft Word. Advice on publishing your work in the journal, including specific information on figures, tables and references, may be found at www.iop.org/journals/authors. Manuscripts should be submitted by e-mail to the Guest Editors at IOPP@sci.lebedev.ru quoting the reference 'Special Issue/ST'. Authors are strongly encouraged to submit their work as soon as possible. Any subsequent change of address should be notified to the publishing office. If you have any questions, please do not hesitate to contact Claire Bedrock, Publisher (claire.bedrock@iop.org) or Margarita A Man'ko, Guest Editor (mmanko@sci.lebedev.ru). For further information on the journal, please visit our Website at www.iop.org/journals/jopb.

76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D.; Dismissal of Proceeding On September 11, 2009, the Deputy Assistant Administrator, Office of Diversion... procedural misconduct, misrepresentations and the subsequent illegitimate denial of due process.'' Id. On...

Mindblindness: metaphor and neuroaesthetics in the works of Silas Weir Mitchell and Simon Baron-Cohen.

PubMed

Swenson, Kristine

2013-01-01

Silas Weir Mitchell's novel, When All the Woods are Green (1894), acknowledges the medical use of mindblindness (agnosia) but also casts it as a developmental disorder, bringing it provocatively close to how current neuropsychologist, Simon Baron-Cohen and his followers use the term in relation to autism. This chapter traces the mindblindess metaphor in the works of Mitchell and Baron-Cohen to show how mindblindness informs the larger paradigms by which they theorize the brain. This analysis suggests that Baron-Cohen, and thus much current thinking about autism spectrum conditions, is influenced by Victorian-era cultural assumptions and neurosexism, a connection that calls for scrutiny of Baron-Cohen's current models of the brain and theories of autism. This chapter also demonstrates the extent to which Mitchell used fiction and advocated writing as neuroaesthetic tools and thus bridged in his work cognitive science and aesthetics--a connection that current scholars of neuroaesthetics are now theorizing. © 2013 Elsevier B.V. All rights reserved.

The State of Educational Technology: Responses to Mitchell.

ERIC Educational Resources Information Center

Agostino, Andrew; And Others

1989-01-01

Presents eight responses to an article in a previous issue by Mitchell, "The Future of Educational Technology Is Past." Highlights include the theory of educational technology, the future of the field of educational technology, cybernetics, educational psychology, systems theory, the role of teachers, control systems, computer assisted…

AGU candidates for office, 1998”2000, Union officers

NASA Astrophysics Data System (ADS)

Marcia K. McNutt. AGU member since 1976, Director of the Monterey Bay Aquarium Research Institute. Major areas of interest are lithospheric tectonics and mantle geodynamics. B.A. in physics (Phi Beta Kappa, summa cum laude), 1973, Colorado College; Ph.D. in Earth science, 1978, Scripps Institution of Oceanography. Researcher at U.S. Geological Survey, Menlo Park, 1979-1982semi Professor at Massachusetts Institute of Technology, 1982-1997. Member of American Association for the Advancement of Science. Authored 74 publications, 45 in AGU journals. Most important publications include The Superswell and mantle dynamics beneath the South Pacific, Science, 248, 969-975,1990semi Marine geodynamics: depth-age revisited, Rev. Geophys., U.S. National Report Supplement, 413-418,1995 Mapping the descent of Indian and Eurasian plates beneath the Tibetan plateau from gravity anomalies, J. Geophys. plume theory to explain multiple episodes of stress-triggered volcanism in the Austral Islands, Nature, in press, 1997. Awarded Macelwane Medal, 1988; Doctor of Science (honoris causa), Colorado College, 1988; NSF Visiting Professorship for Women, Lamont-Doherty Earth Observatory, 1989-1990semi Griswold Professor of Geophysics, MIT, 1991-1997 Outstanding Alumni Award, The Blake Schools, Minneapolis, 1993; Capital Science Lecturer, Carnegie Institution, 1995; Phi Beta Kappa Visiting Scholar, 1996-1997 MIT School of Science Graduate Teaching Prize, 1996. AGU service as Associate Editor and Guest Editor of Journal of Geophysical Research-Solid Earth, member of Program, Budget and Finance, and Audit and Legal Affairs committeessemi; chair of Publications and Macelwane committees, and President of the Tectonophysics Section.

Invasive species compendium: Salvinia molesta D.S. Mitchell

USDA-ARS?s Scientific Manuscript database

Salvinia molesta D.S. Mitchell is an invasive aquatic fern native to a small area of south-eastern Brazil. It has spread throughout the world, forming thick mats of vegetation that decrease dissolved oxygen and pH while outcompeting native vegetation. It has been introduced and established into many...

77 FR 15994 - Southern Region Recreation Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-19

... proposals for areas managed by the Forest Service in Alabama, Arkansas, Florida, Georgia, Kentucky... hard copy of the agenda, should contact Caroline Mitchell at PO Box 1270, Hot Springs, AR 71902 or by... call ahead to facilitate entry into the building. FOR FURTHER INFORMATION CONTACT: Caroline Mitchell...

78 FR 40265 - Notice of Final Federal Agency Action on Proposed Bridge Replacement in Massachusetts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... on Proposed Bridge Replacement in Massachusetts AGENCY: Federal Highway Administration (FHWA), DOT... actions relate to the proposed Mitchell River Bridge (Bridge Street over the Mitchell River) Replacement...). A claim seeking judicial review of the Federal agency actions on the bridge project will be barred...

Recalculation of the Critical Size and Multiplication Constant of a Homogeneous UO{sub 2} - D{sub 2}O Mixtures

DOE R&D Accomplishments Database

Wigner, E. P.; Weinberg, A. M.; Stephenson, J.

1944-02-11

The multiplication constant and optimal concentration of a slurry pile is recalculated on the basis of Mitchell`s experiments on resonance absorption. The smallest chain reacting unit contains 45 to 55 m{sup 3}of D{sub 2}O. (auth)

The Mt. Mitchell scenery assessment

Treesearch

Robert F. Scheele; Gary W. Johnson

1979-01-01

The scenery assessment process for the Mt. Mitchell Suitability/Feasibility Study was conducted by National Park Service personnel and consultants in 1977-78. It combined approaches designed by Lewis (1962) and Jones (1976) in a comparative evaluation of the scenery of two large landscapes in the Appalachian physiographic province. The purpose of this study was to...

Effects of climate change on forest insect and disease outbreaks

Treesearch

David W. Williams; Robert P. Long; Philip M. Wargo; Andrew M. Liebhold

2000-01-01

General circulation models (GCMs) predict dramatic future changes in climate for the northeastern and north central United States under doubled carbon dioxide (CO2) levels (Hansen et al., 1984; Manabe and Wetherald, 1987; Wilson and Mitchell, 1987; Cubasch and Cess, 1990; Mitchell et al., 1990). January temperatures are projected to rise as much...

26th National Neurotrauma Symposium

DTIC Science & Technology

2008-12-31

Sanchez Alvaro I., Puyana Juan C., Fabio Anthony, Adelson P. David 81 COMPARATIVE NEUROPROTECTIVE EFFECTS OF CYCLOSPORIN A AND NIM811, A NON...Xiangbai, Fabio Anthony, Yuan Zhifang, Niyonkuru Christian, Wagner Amy 99 ACTIVATION OF MITOCHONDRIAL UNCOUPLING PROTEINS BY POLYUNSATURATED FATTY...Metabolism/Physiological Assessments TBI Mitchell Cohen University of California, San Francisco Ferguson Adam, Cohen Mitchell, Morabito Diane

Myxobolus neurophilus: a common myxosporidian parasite infecting yellow perch Perca flavacens (Mitchell) in Saskatchewan, Canada

USDA-ARS?s Scientific Manuscript database

The goal of this study was to identify a myxosporidian parasite infecting the central nervous system of yellow perch Perca flavacens (Mitchell) observed while investigating a fish kill in Saskatchewan, Canada. Fish were collected from seven different lakes, from 2 distinct watersheds. Sixty-four p...

78 FR 12050 - Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application Accepted for Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

...-diameter stream diversion tunnel that would be converted to reservoir outlet works after project... afterbay to an outlet structure on a tributary to Sweetheart Creek; and an existing tributary stream... Mitchell, Business Manager, Juneau Hydropower, Inc. P.O. Box 22775, Juneau, AK 99802; email: duff.mitchell...

78 FR 2990 - Juneau Hydropower, Inc.; Notice of Successive Preliminary Permit Application Accepted for Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

...-diameter stream diversion tunnel that would be converted to reservoir outlet works after project... afterbay to an outlet structure on a tributary to Sweetheart Creek; and an existing tributary stream... Mitchell, Business Manager, Juneau Hydropower, Inc. P.O. Box 22775, Juneau, AK 99802; email: duff.mitchell...

Status of Imported and Native Predators of the Balsam Woolly Aphid on Mt. Mitchell, North Carolina

Treesearch

Gerhard F. Fedde

1972-01-01

On the Mt. Mitchell area during the summer of 1968, 20 stands of Fraser fir, Abies fraseri (Pursh) Poir., infested by the balsam woolly aphid, Adelges piceae (Ratzeburg), were examined for native and previously imported predators of the aphid. Laricobius erichsonii Bosenhauer (Coleoptera: Derodontidae) was...

Scratch that: MIT's Mitchel Resnick Says Kids Should Do It for Themselves

ERIC Educational Resources Information Center

Traylor, Scott

2008-01-01

Mitchel Resnick is a researcher, inventor, and professor at MIT's Media Laboratory in Cambridge, MA, and the founder of the Lifelong Kindergarten Group at MIT. He is the lead innovator behind many cutting-edge learning technologies and projects for children, including the Computer Clubhouse, PicoCrickets, and the wildly successful consumer…

Silas Weir Mitchell and "The Strange Case of George Dedlow".

PubMed

Kline, David G

2016-07-01

It has been said of Silas Weir Mitchell (1829-1914) that as a young man he was first among the physiologists of his day, in middle age first among physicians, and as an older man, one of the most noted novelists of his country. Mitchell's novels were written in his later life as a means to avoid boredom during lengthy summer vacations that were the norm for that time among the affluent members of Philadelphia society. These novels were criticized by some because of poor plots, which in some instances failed to move along, or for text that offered a stereotyped depiction of genteel society and the effects that war or personal disaster had on the characters' behavior The criticism came despite the fact that all critics agreed that Mitchell's portrayals of psychopathology in his fictional characters was unique and accurate. However, in his 30s, Mitchell had written and by chance had published a fictional short story that not only transcended such criticisms but became immensely popular. "The Strange Case of George Dedlow" portrays a union officer who was not a physician but who had some medical background and who sustained a series of war wounds leading to severe nerve pain, the author's first description of causalgia, multiple amputations, and the psychological as well as physical symptoms of phantom limb syndrome. The protagonist tells of his torments in the first person in a very engaging fashion. Thus, long before he began writing his, at that time, acclaimed novels in the 1880s, Mitchell wrote a piece of fiction that combines accurate and very important medical observations with fiction of great historical interest. The following rendering of this now classic short story includes selected quotes and some interpretation and is perhaps appropriate for this year, 2 years after the centenary year of his death in 1914.

Demonstration and Validation of an Improved Airborne Electromagnetic System for UXO Detection and Mapping

DTIC Science & Technology

2010-05-01

William E. Doll Battelle 105 Mitchell Road Suite 103 Oak Ridge, TN 37830 865-483-2548 865-599-6165 dollw@battelle.org Airborne Survey...Manager David T. Bell Battelle 105 Mitchell Road Suite 103 Oak Ridge, TN 37830 865-483-2547 865-250-0578 belldt@battelle.org Battelle-Oak Ridge

Meeting the Challenge of Systemic Change in Geography Education: Lucy Sprague Mitchell's Young Geographers

ERIC Educational Resources Information Center

Downs, Roger M.

2016-01-01

The history of K-12 geography education has been characterized by recurrent high hopes and dashed expectations. There have, however, been moments when the trajectory of geography education might have changed to offer students the opportunity to develop a thorough working knowledge of geography. Lucy Sprague Mitchell's geography program developed…

Alpine Forest. Mount Mitchell State Park: An Environmental Education Learning Experience Designed for Grades 4-6.

ERIC Educational Resources Information Center

Bradley, Jack L., Jr.; Beazley, Lea J.; Cook, Carrie

This curriculum packet was developed to provide environmental education through a series of hands-on activities for the classroom and the outdoor setting of Mount Mitchell State Park, North Carolina. Designed for grades 3 through 6, the packet meets established curriculum objectives of the North Carolina Department of Public Instruction's Standard…

Human Estimation of Slope, Distance, and Height of Terrain in Simulated Lunar Conditions

DTIC Science & Technology

2009-02-01

directions. During the Apollo 14 hike to Cone Crater, Astronaut Mitchell recognized the crater “Old Nameless ” and judged its distance as 200 – 300...and Mitchell approached Station B2 during their climb of Cone Crater in Apollo 14, they approached a larger crater, thought to be “Old Nameless ” [44

Sometimes Pursuits Don't Pan Out: Anticipated Destinations and Other Caveats--Comment on Hom, Mitchell, Lee, and Griffeth (2012)

ERIC Educational Resources Information Center

Bergman, Mindy E.; Payne, Stephanie C.; Boswell, Wendy R.

2012-01-01

Hom, Mitchell, Lee, and Griffeth (2012) presented an extensive review of employee turnover research, reconceptualized the turnover criterion to include multiple destinations, and proposed to expand the predictor domain. They illuminated the multiple destinations employees pursue following turnover. By crossing desire to remain and volitional…

William Horner Andrews (1887-1953)- first professor of physiology at Onderstepoort.

PubMed

Verwoerd, D W; Andrews, W J H

2011-03-01

W H Andrews qualified as a veterinarian in London in 1908 and was recruited soon after, in 1909, by Sir Arnold Theiler to join the staff of the newly established veterinary laboratory at Onderstepoort. After initial studies on the treatment of trypanosomosis and on snake venoms he was deployed by Theiler in 1911 to start research on lamsiekte (botulism)at a field station on the farm Kaffraria near Christiana, where he met and married his wife Doris. After a stint as Captain in the SA Veterinary Corps during World War I he succeeded D T Mitchell as head of the Allerton Laboratory in 1918, where he excelled in research on toxic plants, inter alia identifying Matricaria nigellaefolia as the cause of staggers in cattle. When the Faculty of Veterinary Science was established in 1920 he was appointed as the first Professor of Physiology. After the graduation of the first class in 1924, and due to health problems, he returned to the UK, first to the Royal Veterinary College and then to the Weybridge Veterinary Laboratories of which he became Director in 1927. After his retirement in 1947 he returned to South Africa as a guest worker at Onderstepoort where he again became involved in teaching physiology when Prof. Quin unexpectedly died in 1950. Andrews died in Pretoria in 1953 and was buried in the Rebecca Street Cemetery.

Reflections of a former vice president on long-time cardiac experiences

PubMed Central

Cheney, Richard B. (“Dick”)

2009-01-01

Editor's Note: Mr. Cheney, 46th vice president of the United States, was the featured guest speaker at the third annual Baylor Health Care System Foundation Heart and Vascular Dinner on April 7, 2009, at the home of Kathy and Harlan Crow (Figures 1 and 2). Previous speakers were former Senator Bob Dole and Denton Cooley, MD. Cheney spoke about his experiences with cardiovascular disease, his 40-year career in public service, and the challenges facing health care. Mr. Cheney has had four heart attacks and numerous other cardiovascular episodes, beginning with his first heart attack when he was 37 years old. The Foundation's Heart and Vascular Campaign, which has raised more than $11.2 million toward its $20 million fundraising goal, supports eight cardiology fellows and four residents in vascular surgery, as well as cardiovascular research at Baylor University Medical Center at Dallas, Baylor Hamilton Heart and Vascular Hospital, and The Heart Hospital Baylor Plano. PMID:21240297

Absorption and folding of melittin onto lipid bilayer membranes via unbiased atomic detail microsecond molecular dynamics simulation.

PubMed

Chen, Charles H; Wiedman, Gregory; Khan, Ayesha; Ulmschneider, Martin B

2014-09-01

Unbiased molecular simulation is a powerful tool to study the atomic details driving functional structural changes or folding pathways of highly fluid systems, which present great challenges experimentally. Here we apply unbiased long-timescale molecular dynamics simulation to study the ab initio folding and partitioning of melittin, a template amphiphilic membrane active peptide. The simulations reveal that the peptide binds strongly to the lipid bilayer in an unstructured configuration. Interfacial folding results in a localized bilayer deformation. Akin to purely hydrophobic transmembrane segments the surface bound native helical conformer is highly resistant against thermal denaturation. Circular dichroism spectroscopy experiments confirm the strong binding and thermostability of the peptide. The study highlights the utility of molecular dynamics simulations for studying transient mechanisms in fluid lipid bilayer systems. This article is part of a Special Issue entitled: Interfacially Active Peptides and Proteins. Guest Editors: William C. Wimley and Kalina Hristova. Copyright © 2014. Published by Elsevier B.V.

KSC-98pc419

NASA Image and Video Library

1998-03-25

KENNEDY SPACE CENTER, FLA. -- John F. Kennedy Jr., editor-in-chief of George Magazine, greets invited guests at the Home Box Office (HBO) and Imagine Entertainment premiere of the 12-part miniseries "From the Earth to the Moon" at Kennedy Space Center (KSC). The series was filmed in part on location at KSC and dramatizes the human aspects of NASA's efforts to launch Americans to the Moon. The miniseries highlights NASA's Apollo program and the events leading up to and including the six successful missions to the Moon. A special 500-seat theater was constructed next to the Apollo/Saturn V Center for the KSC premiere showing. Speakers at the event included KSC Director Roy Bridges (at right); Jeff Bewkes, chairman and CEO for HBO; and John F. Kennedy Jr. Also attending the event, which featured the episode entitled "1968," were Buzz Aldrin, Apollo 11 astronaut, and Al Worden, Apollo 15 astronaut. The original miniseries event, created for HBO by actor Tom Hanks and Imagine Entertainment, will premiere on HBO beginning April 5, 1998

Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms☆

PubMed Central

Mori, Takaharu; Miyashita, Naoyuki; Im, Wonpil; Feig, Michael; Sugita, Yuji

2016-01-01

This paper reviews various enhanced conformational sampling methods and explicit/implicit solvent/membrane models, as well as their recent applications to the exploration of the structure and dynamics of membranes and membrane proteins. Molecular dynamics simulations have become an essential tool to investigate biological problems, and their success relies on proper molecular models together with efficient conformational sampling methods. The implicit representation of solvent/membrane environments is reasonable approximation to the explicit all-atom models, considering the balance between computational cost and simulation accuracy. Implicit models can be easily combined with replica-exchange molecular dynamics methods to explore a wider conformational space of a protein. Other molecular models and enhanced conformational sampling methods are also briefly discussed. As application examples, we introduce recent simulation studies of glycophorin A, phospholamban, amyloid precursor protein, and mixed lipid bilayers and discuss the accuracy and efficiency of each simulation model and method. This article is part of a Special Issue entitled: Membrane Proteins. Guest Editors: J.C. Gumbart and Sergei Noskov. PMID:26766517

Practicing safe cell culture: applied process designs for minimizing virus contamination risk.

PubMed

Kiss, Robert D

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Genentech responded to a virus contamination in its biologics manufacturing facility by developing and implementing a series of barriers specifically designed to prevent recurrence of this significant and impactful event. The barriers included steps to inactivate or remove potential virus particles from the many raw materials used in cell culture processing. Additionally, analytical testing barriers provided protection of the downstream processing areas should a culture contamination occur, and robust virus clearance capability provided further assurance of virus safety should a low level contamination go undetected. This conference proceeding will review Genentech's approach, and lessons learned, in minimizing virus contamination risk in cell culture processes through multiple layers of targeted barriers designed to deliver biologics products with high success rates.

Astrophysical implications of extraterrestrial materials: A special issue for Ernst K. Zinner

NASA Astrophysics Data System (ADS)

Nittler, Larry R.

2018-01-01

This special issue is dedicated to the memory of Dr. Ernst K. Zinner (Fig. 1). Dr. Zinner (1937-2015) was a pioneer in the use of Secondary Ion Mass Spectrometry (SIMS) in geo- and cosmochemistry. His contributions to science were vast, but in addition to his foundational SIMS development work, he is best known for the discovery and detailed characterization of presolar stardust grains in meteorites. This discovery opened up important new connections between astrophysics and meteoritical research and this is the overarching theme of this issue. Throughout his career, Ernst was a teacher, mentor, friend, and generous collaborator to legions of scientists. This issue presents research by many who were taught by, inspired by, and/or collaborated with this innovative cosmochemist and astrophysicist. In addition to the author, Ernst's former students and collaborators Drs. Christine Floss (Washington University) Peter Hoppe (MPI for chemistry, Mainz, Germany), and Kevin McKeegan (University of California, Los Angeles) served as Guest Editors for this issue.

Joint Training In Combined Entry Operations

DTIC Science & Technology

2014-02-13

AIR WAR COLLEGE AIR UNIVERSITY JOINT TRAINING IN COMBINED ENTRY OPERATIONS by Ethan Mitchell, CDR, USN A Research Report Submitted...government. DISTRIBUTION A . Approved for public release: distribution unlimited. 2 Biography CDR Ethan Mitchell is assigned to the Air War College...Areas of Responsibility. Ashore, her served in the requirements directorate on the Commander, Second Fleet staff and earned a Master’s of Science

To Get Good Fund Raisers, a University Goes to Great Lengths

ERIC Educational Resources Information Center

Blumenstyk, Goldie

2008-01-01

As vice chancellor for advancement at the University of California at Irvine, Thomas J. Mitchell is running two campaigns: one to raise $1-billion for the university, and the other to attract and keep the people whose job it is to raise that money. Since joining Irvine six years ago from Iowa State University, Mitchell has deployed a range of…

Medical Readiness of Air Force Members Not on Deployment for Shortfall Deployments

DTIC Science & Technology

2001-05-01

Thelma Mitchell, Major, United States Air Force, Nurse Corps APPROVED: _______________________________________12 April 2001...to those who greatly contributed to the initiation, process and completion of this study, especially the staff of the Graduate School of Nursing ...T. MITCHELL, BSN THESIS Presented to the Graduate School of Nursing Faculty of The Uniformed Services University of the Health Sciences in

Reduction of Iodine by Phosphorus(I): Integration of the Rate Equation

ERIC Educational Resources Information Center

Kustin, Kenneth; Ross, Edward W.

2005-01-01

A. D. Mitchell's work on the phosphorus(I) reduction of the halogens and of mercury(II) and copper(II) chlorides is examined. A review of some salient characteristics of the Mitchell mechanism is presented, together with a discussion on how a student might benefit from a case study of the phosphorus(I) reduction of iodine or the similarly behaving…

Birth of Consciousness: Hate Crimes (and Hate Speech) on Campus--A Review of "Wisconsin v Mitchell."

ERIC Educational Resources Information Center

Brown, Valerie L.

1994-01-01

Examines "Wisconsin v. Mitchell," a Supreme Court ruling that the First Amendment was not violated by the application at sentencing of a penalty-enhancement provision in a hate crime statute. Discusses related cases and the Hate Crime Statistics Act of 1990, and concludes with a review of the implications of "Wisconsin" on…

Remaining Safe and Avoiding Dangers Online: A Social Media Q&A with Kimberly Mitchell

ERIC Educational Resources Information Center

Prevention Researcher, 2010

2010-01-01

The news media is often full of stories about the dangers of social media, including such concerns as cyberbullying and sexting. In this article, Kimberly Mitchell, a researcher noted for her experience on youth internet victimization, answers questions about the risks of social media and how we can keep youth safe online. Questions in this Q&A…

29 CFR 779.324 - Recognition “in.”

Code of Federal Regulations, 2013 CFR

2013-07-01

... emphasized in the debates in Congress that while the views of an industry are significant and material in... Tire Co., 383 U.S. 190; Mitchell v. City Ice Co., 273 F. 2d 560 (CA-5); Durkin v. Casa Baldrich, Inc., 111 F. Supp. 71 (DCPR) affirmed 214 F. 2d 703 (CA-1); see also Aetna Finance Co. v. Mitchell, 247 F...

29 CFR 779.324 - Recognition “in.”

Code of Federal Regulations, 2012 CFR

2012-07-01

... emphasized in the debates in Congress that while the views of an industry are significant and material in... Tire Co., 383 U.S. 190; Mitchell v. City Ice Co., 273 F. 2d 560 (CA-5); Durkin v. Casa Baldrich, Inc., 111 F. Supp. 71 (DCPR) affirmed 214 F. 2d 703 (CA-1); see also Aetna Finance Co. v. Mitchell, 247 F...

29 CFR 779.324 - Recognition “in.”

Code of Federal Regulations, 2014 CFR

2014-07-01

... emphasized in the debates in Congress that while the views of an industry are significant and material in... Tire Co., 383 U.S. 190; Mitchell v. City Ice Co., 273 F. 2d 560 (CA-5); Durkin v. Casa Baldrich, Inc., 111 F. Supp. 71 (DCPR) affirmed 214 F. 2d 703 (CA-1); see also Aetna Finance Co. v. Mitchell, 247 F...

29 CFR 791.2 - Joint employment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the employee by the other joint employer or employers. 4 Walling v. Friend, et al., 156 F. 2d 429 (C.... Hargrave, 129 F. 2d 655 (C.A. 10); Slover v. Wathen, 140 F. 2d 258 (C.A. 4); Mitchell v. Bowman, 131 F. Supp., 520 (M.D. Ala. 1954); Mitchell v. Thompson Materials & Construction Co., et al., 27 Labor Cases...

29 CFR 791.2 - Joint employment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the employee by the other joint employer or employers. 4 Walling v. Friend, et al., 156 F. 2d 429 (C.... Hargrave, 129 F. 2d 655 (C.A. 10); Slover v. Wathen, 140 F. 2d 258 (C.A. 4); Mitchell v. Bowman, 131 F. Supp., 520 (M.D. Ala. 1954); Mitchell v. Thompson Materials & Construction Co., et al., 27 Labor Cases...

29 CFR 779.324 - Recognition “in.”

Code of Federal Regulations, 2011 CFR

2011-07-01

... emphasized in the debates in Congress that while the views of an industry are significant and material in... Tire Co., 383 U.S. 190; Mitchell v. City Ice Co., 273 F. 2d 560 (CA-5); Durkin v. Casa Baldrich, Inc., 111 F. Supp. 71 (DCPR) affirmed 214 F. 2d 703 (CA-1); see also Aetna Finance Co. v. Mitchell, 247 F...

29 CFR 791.2 - Joint employment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the employee by the other joint employer or employers. 4 Walling v. Friend, et al., 156 F. 2d 429 (C.... Hargrave, 129 F. 2d 655 (C.A. 10); Slover v. Wathen, 140 F. 2d 258 (C.A. 4); Mitchell v. Bowman, 131 F. Supp., 520 (M.D. Ala. 1954); Mitchell v. Thompson Materials & Construction Co., et al., 27 Labor Cases...

29 CFR 791.2 - Joint employment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the employee by the other joint employer or employers. 4 Walling v. Friend, et al., 156 F. 2d 429 (C.... Hargrave, 129 F. 2d 655 (C.A. 10); Slover v. Wathen, 140 F. 2d 258 (C.A. 4); Mitchell v. Bowman, 131 F. Supp., 520 (M.D. Ala. 1954); Mitchell v. Thompson Materials & Construction Co., et al., 27 Labor Cases...

A Second Level Pictorial Turn? The Emergence of Digital Ekphrasis from The Visuality of New Media

ERIC Educational Resources Information Center

Shiel, Nina

2013-01-01

The increasing visuality of our culture was observed in 1994 by Mitchell, who coined the term "pictorial turn" to describe the interest in the visual taking place in culture and discourse (Mitchell, 1994). Since then, this process has increased further, particularly in all the areas of digital/new media. This chapter will consider this…

The Links between Migration, Poverty and Health: Evidence from Khayelitsha and Mitchell's Plain

ERIC Educational Resources Information Center

Ndegwa, David; Horner, Dudley; Esau, Faldie

2007-01-01

In the mid-1950s, the City of Cape Town was part of a wider area demarcated as a Coloured Labour Preference Area. The free movement of African people into the city was strictly controlled and the residential areas were segregated along racial lines. In terms of Apartheid's grand design, an area designated Mitchell's Plain was demarcated for…

Further Clarifying Proximal Withdrawal States and the Turnover Criterion Space: Comment on Hom, Mitchell, Lee, and Griffeth (2012)

ERIC Educational Resources Information Center

Maertz, Carl P., Jr.

2012-01-01

In "Reviewing Employee Turnover: Focusing on Proximal Withdrawal States and an Expanded Criterion," Hom, Mitchell, Lee, and Griffeth (2012) brought together many of the most important content and process factors in the employee turnover literature. In this paper, I attempt to clarify the true contributions of this framework for the turnover area…

Establishing and Maintaining Trust for an Airborne Network. Search and Rescue Enterprise: Security Assessment Report

DTIC Science & Technology

2014-12-01

Area Code) (937) 528-8142 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39-18 1 MITCHELL, LOLITA V CIV USAF AFMC AFRL/RYOX To...MITCHELL, LOLITA V CIV USAF AFMC AFRL/RYOX Subject: FW: Final Report Change - Search and Rescue Security Assessment From: J M Schlesselman [mailto:joe

Maria Mitchell's Comet - a Challenge Once More?

NASA Astrophysics Data System (ADS)

Boyce, P. B.; Graham, A. P.; Strelnitski, V.

1997-12-01

This year marks the sesquicentennial of the discovery of a fateful comet by Maria Mitchell (1 October 1847). This was one of the first telescopic comets ever discovered and the first one discovered by a woman. It brought Maria Mitchell the gold medal from the King of Denmark, the first appointment of a woman as professor of Astronomy (at Vassar College) and the fame to be the first (and for ninety years - the only) woman - member of the American Academy of Arts and Sciences. It gave Maria Mitchell an unusually favorable opportunity to struggle for the rights of American women in science. We restore the circumstances of this discovery, and present the results of a modern re-calculation of the orbit of the comet, including its present position in the sky and its ephemeris for the next 50 years. The comet is 32(m) now and will slowly decrease in brightness. Our ability to detect faint objects has improved dramatically over the 150 years since the comet was discovered. By extrapolation, we show that modern technology may catch up with the declining brightness of the comet by the middle of the next century. Another challenge for astronomers!

EDITORIAL: Message from the Editor Message from the Editor

NASA Astrophysics Data System (ADS)

Thomas, Paul

2011-01-01

As usual, being an even year, the 23rd IAEA Fusion Energy Conference took place at Daejeon, Korea. The event was notable not just for the quality of the presentations but also for the spectacular opening ceremony, in the presence of the Prime Minister, Kim Hwang-sik. The Prime Minister affirmed the importance of research into fusion energy research and pledged support for ITER. Such political visibility is good news, of course, but it brings with it the obligation to perform. Fortunately, good performance was much in evidence in the papers presented at the conference, of which a significant proportion contain 'ITER' in the title. Given this importance of ITER and the undertaking by the Nuclear Fusion journal to publish papers associated with Fusion Energy Conference presentations, the Nuclear Fusion Editorial Board has decided to adopt a simplified journal scope that encompasses technology papers more naturally. The scope is available from http://iopscience.iop.org/0029-5515/page/Journal%20information but is reproduced here for clarity: Nuclear Fusion publishes articles making significant advances to the field of controlled thermonuclear fusion. The journal scope includes: the production, heating and confinement of high temperature plasmas; the physical properties of such plasmas; the experimental or theoretical methods of exploring or explaining them; fusion reactor physics; reactor concepts; fusion technologies. The key to scope acceptability is now '....significant advances....' rather than any particular area of controlled thermonuclear fusion research. It is hoped that this will make scope decisions easier for the Nuclear Fusion office, the referees and the Editor.The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. This is underlined by the fact that Nuclear Fusion has received an impact factor of 4.270, as listed in ISI's 2009 Science Citation Index. The journal depends entirely on its authors and referees and so I would like to thank them all for their work in 2010 and look forward to a continuing, successful collaboration in 2011. Refereeing The Nuclear Fusion editorial office understands how much effort is required of our referees. The Editorial Board decided that an expression of thanks to our most loyal referees is appropriate and so, since January 2005, we have been offering the top ten most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. This year, two of the top referees have reviewed four or more manuscripts in the period November 2009 to November 2010 and provided particularly detailed advice to the authors. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their special issues is also excluded from consideration. The following people have been selected: Osamu Naito, Japan Atomic Energy Agency, Naka, Japan Masahiro Kobayashi, National Institute for Fusion Science, Toki, Japan Duccio Testa, Lausanne Federal Polytechnic University, Switzerland Vladimir Pustovitov, Russian Research Centre, Kurchatov Insitute, Russia Christopher Holland, University of California at San Diego, USA Yuri Gribov, ITER International Organisation, Cadarache, France Eriko Jotaki, Kyushu University, Japan Sven Wiesen, Jülich Research Centre, Germany Viktor S. Marchenko, Ukraine National Academy of Sciences, Ukraine Richard Stephens, General Atomics, USA In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2010. Our thanks to them! Authors The winner of the 2010 Nuclear Fusion Award was J.E. Rice et al for the paper entitled 'Inter-machine comparison of intrinsic toroidal rotation in tokamaks' (2007 Nucl. Fusion 47 1618-24). The prize was awarded at the Fusion Energy Conference in Daejeon, together with the 2009 Nuclear Fusion Award to Steve Sabbagh. The Board of Editors Roger Weynants retired as a member of the Board of Editors in 2010. On behalf of the Nuclear Fusion office and the Chairman of the Board, Mitsuru Kikuchi, I would like to thank him for his effort in support of the journal; Roger was one of the most active members of the Board and his balanced and competent advice was extremely valuable on many difficult decisions. At the same time we welcome Tony Donne whom I am sure does not need any introduction to the readers of Nuclear Fusion; I am confident he can only further the success of the journal. The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors and referees, so its success is also due to the tireless and largely unsung efforts of the Nuclear Fusion office in Vienna and IOP Publishing in Bristol. I would like to express my personal thanks to Maria Bergamini-Roedler, Katja Haslinger, Sophy Le Masurier, Yasmin McGlashan, Caroline Wilkinson, Sarah Ryder, Katie Gerrard and Stephanie Kent for the support that they have given to me, the authors and the referees. Season's greetings I would like to wish our readers, authors, referees and Board of Editors season's greetings and thank them for their contributions to Nuclear Fusion in 2010.

Five early accounts of phantom limb in context: Paré, Descartes, Lemos, Bell, and Mitchell.

PubMed

Finger, Stanley; Hustwit, Meredith P

2003-03-01

PHANTOM LIMB WAS described long before American physician and surgeon Silas Weir Mitchell coined the term and drew attention to the disorder in the 1860s. The early descriptions of Ambroise Paré, René Descartes, Aaron Lemos, Charles Bell, and then Mitchell of this strange consequence of amputation are presented in historical and cultural context. These five men described phantom limbs for various reasons. They also differed when it came to explaining and dealing with these illusory sensations. The rich history of phantom limbs can begin to be appreciated by viewing the contributions of these individuals in perspective and by realizing that their writings represent only a fraction of what was published about phantom limbs more than 130 years ago.

CALL FOR PAPERS: Special cluster issue on `Experimental studies of zonal flow and turbulence'

NASA Astrophysics Data System (ADS)

Itoh, S.-I.

2005-07-01

Plasma Physics and Controlled Fusion (PPCF) invites submissions on the topic of `Experimental studies of zonal flow and turbulence', for consideration for a special topical cluster of articles to be published early in 2006. The topical cluster will be published in an issue of PPCF, combined with regular articles. The Guest Editor for the special cluster will be S-I Itoh, Kyushu University, Japan. There has been remarkable progress in the area of structure formation by turbulence. One of the highlights has been the physics of zonal flow and drift wave turbulence in toroidal plasmas. Extensive theoretical as well as computational studies have revealed the various mechanisms in turbulence and zonal flows. At the same time, experimental research on the zonal flow, geodesic acoustic modes and generation of global electric field by turbulence has evolved rapidly. Fast growth in reports of experimental results has stimulated further efforts to develop increased knowledge and systematic understanding. Each paper considered for the special cluster should describe the present research status and new scientific knowledge/results from the authors on experimental studies of zonal flow, geodesic acoustic modes and generation of electric field by turbulence (including studies of Reynolds-Maxwell stresses, etc). Manuscripts submitted to this special cluster in Plasma Physics and Controlled Fusion will be refereed according to the normal criteria and procedures of the journal. The Guest Editor guides the progress of the cluster from the initial open call, through the standard refereeing process, to publication. To be considered for inclusion in the special cluster, articles must be submitted by 2 September 2005 and must clearly state `for inclusion in the Turbulent Plasma Cluster'. Articles submitted after this deadline may not be included in the cluster issue but may be published in a later issue of the journal. Please submit your manuscript electronically via our web site at www.iop.org/journals/ppcf or by e-mail to mailto:ppcf@iop.org. Electronic submissions are encouraged but if you wish to submit a hard copy of your article then please send your typescript, a set of original figures and a covering letter to: The Publishing Administrator Plasma Physics and Controlled Fusion Institute of Physics Publishing Dirac House Temple Back Bristol BS1 6BE UK Further information on how to submit may be obtained on request by e-mailing the journal at the above address. Alternatively, visit the homepage of the journal (www.iop.org/journals/ppcf).

Special issue on coherent states: mathematical and physical aspects Special issue on coherent states: mathematical and physical aspects

NASA Astrophysics Data System (ADS)

Twareque Ali, Syed; Antoine, Jean-Pierre; Bagarello, Fabio; Gazeau, Jean-Pierre

2011-07-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to coherent states. The motivation behind this special issue is to gather in a single comprehensive volume the main aspects (past and present), latest developments, different viewpoints and directions being followed in this multidisciplinary field. Given the impressive development of the field in the past two decades, the topicality of such a volume can hardly be overemphasized. We strongly believe that such a special issue could become a particularly valuable reference for the broad scientific community working in mathematical and theoretical physics, as well as in signal processing and mathematics. Editorial policy The Guest Editors for this issue will be Syed Twareque Ali, Jean-Pierre Antoine, Fabio Bagarello and Jean-Pierre Gazeau. Potential topics include, but are not limited to, developments in the theory and applications of coherent states in: quantum optics, optomechanics, Bose-Einstein condensates quantum information, quantum measurement signal processing quantum gravity pseudo-Hermitian quantum mechanics supersymmetric quantum mechanics non-commutative quantum mechanics quantization theory harmonic and functional analysis operator theory Berezin-Toeplitz operators, PT-symmetric operators holomorphic representation theory, reproducing kernel spaces generalization of coherent states All contributions will be refereed and processed according to the usual procedure of the journal. Papers should report original and significant research that has not already been published. Guidelines for preparation of contributions The deadline for contributed papers will be 31 October 2011. This deadline will allow the special issue to appear before the end of May 2012 There is a nominal page limit of 15 printed pages per contribution (invited review papers can be longer). For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on publishing your work in Journal of Physics A: Mathematical and Theoretical may be found at iopscience.iop.org/jphysa. Contributions to the special issue should be submitted by web upload via authors.iop.org/, or by email to jphysa@iop.org, quoting `JPhysA Special issue on coherent states: mathematical and physical aspects'. Submissions should ideally be in standard LaTeX form. Please see the website for further information on electronic submissions. All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. The special issue will be published in the print and online versions of the journal.

Special issue on coherent states: mathematical and physical aspects Special issue on coherent states: mathematical and physical aspects

NASA Astrophysics Data System (ADS)

Twareque Ali, Syed; Antoine, Jean-Pierre; Bagarello, Fabio; Gazeau, Jean-Pierre

2011-06-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to coherent states. The motivation behind this special issue is to gather in a single comprehensive volume the main aspects (past and present), latest developments, different viewpoints and directions being followed in this multidisciplinary field. Given the impressive development of the field in the past two decades, the topicality of such a volume can hardly be overemphasized. We strongly believe that such a special issue could become a particularly valuable reference for the broad scientific community working in mathematical and theoretical physics, as well as in signal processing and mathematics. Editorial policy The Guest Editors for this issue will be Syed Twareque Ali, Jean-Pierre Antoine, Fabio Bagarello and Jean-Pierre Gazeau. Potential topics include, but are not limited to, developments in the theory and applications of coherent states in: quantum optics, optomechanics, Bose-Einstein condensates quantum information, quantum measurement signal processing quantum gravity pseudo-Hermitian quantum mechanics supersymmetric quantum mechanics non-commutative quantum mechanics quantization theory harmonic and functional analysis operator theory Berezin-Toeplitz operators, PT-symmetric operators holomorphic representation theory, reproducing kernel spaces generalization of coherent states All contributions will be refereed and processed according to the usual procedure of the journal. Papers should report original and significant research that has not already been published. Guidelines for preparation of contributions The deadline for contributed papers will be 31 October 2011. This deadline will allow the special issue to appear before the end of May 2012 There is a nominal page limit of 15 printed pages per contribution (invited review papers can be longer). For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on publishing your work in Journal of Physics A: Mathematical and Theoretical may be found at iopscience.iop.org/jphysa. Contributions to the special issue should be submitted by web upload via authors.iop.org/, or by email to jphysa@iop.org, quoting `JPhysA Special issue on coherent states: mathematical and physical aspects'. Submissions should ideally be in standard LaTeX form. Please see the website for further information on electronic submissions. All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. The special issue will be published in the print and online versions of the journal.

CALL FOR PAPERS: Progress in Supersymmetric Quantum Mechanics

NASA Astrophysics Data System (ADS)

2003-12-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and General dedicated to the subject of Supersymmetric Quantum Mechanics as featured in the International Conference in Supersymmetric Quantum Mechanics (PSQM03), 15--19 July 2003, University of Valladolid, Spain (http://metodos.fam.cie.uva.es/~susy_qm_03/). Participants at that meeting, as well as other researchers working in this area or in related fields, are invited to submit a research paper to this issue. The Editorial Board has invited Irina Areféva, David J Fernández, Véronique Hussin, Javier Negro, Luis M Nieto and Boris F Samsonov to act as Guest Editors for the special issue. Their criteria for acceptance of contributions are as follows: bullet The subject of the paper should be in the general area covered by the PSQM03 conference. bullet Contributions will be refereed and processed according to the usual mechanisms of the journal. bullet Papers should present substantial new results (they should not be simply reviews of authors' own work that is already published elsewhere). The guidelines for the preparation of contributions are as follows: bullet DEADLINE for submission of contributions is 15 January 2004. This deadline will allow the special issue to appear in approximately September 2004. bullet There is a page limit of 15 pages per research contribution. Further advice on publishing your work in Journal of Physics A: Mathematical and General may be found at www.iop.org/Journals/jphysa. bullet Contributions to the special issue should if possible be submitted electronically at www.iop.org/Journals/jphysa or by e-mail to jphysa@iop.org, quoting `JPhysA special issue --- PSQM03'. Submissions should ideally be in either standard LaTeX form or Microsoft Word. Please see the web site for further information on electronic submissions. bullet Authors unable to submit by email may send hard copy contributions to: Journal of Physics A, Institute of Physics Publishing, Dirac House, Temple Back, Bristol BS1 6BE, UK, enclosing the electronic code if available and mentioning `PSQM03 special issue'. bullet All contributions should be accompanied by a readme file or covering letter giving the postal and e-mail addresses for correspondence. Any subsequent change of address should be notified to the publishing office. The corresponding author of each contribution will receive a complimentary copy of the issue. Irina Areféva, David J Fernández, Véronique Hussin, Javier Negro, Luis M Nieto and Boris F Samsonov Guest Editors

29 CFR 779.118 - Employees providing central services for multi-unit organizations.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Employees providing central services for a multiunit organization may be engaged both “in commerce” and “in... and clerical work relating to such activities) for various retail units of a chain are covered under..., affirming, 128 F. 2d 935 (CA-5); Mitchell v. C. & P. Stores, 286 F. 2d 109 (CA-5); Mitchell v. E. G. Shinner...

29 CFR 779.118 - Employees providing central services for multi-unit organizations.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Employees providing central services for a multiunit organization may be engaged both “in commerce” and “in... and clerical work relating to such activities) for various retail units of a chain are covered under..., affirming, 128 F. 2d 935 (CA-5); Mitchell v. C. & P. Stores, 286 F. 2d 109 (CA-5); Mitchell v. E. G. Shinner...

29 CFR 779.118 - Employees providing central services for multi-unit organizations.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Employees providing central services for a multiunit organization may be engaged both “in commerce” and “in... and clerical work relating to such activities) for various retail units of a chain are covered under..., affirming, 128 F. 2d 935 (CA-5); Mitchell v. C. & P. Stores, 286 F. 2d 109 (CA-5); Mitchell v. E. G. Shinner...

29 CFR 779.118 - Employees providing central services for multi-unit organizations.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Employees providing central services for a multiunit organization may be engaged both “in commerce” and “in... and clerical work relating to such activities) for various retail units of a chain are covered under..., affirming, 128 F. 2d 935 (CA-5); Mitchell v. C. & P. Stores, 286 F. 2d 109 (CA-5); Mitchell v. E. G. Shinner...

29 CFR 779.118 - Employees providing central services for multi-unit organizations.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Employees providing central services for a multiunit organization may be engaged both “in commerce” and “in... and clerical work relating to such activities) for various retail units of a chain are covered under..., affirming, 128 F. 2d 935 (CA-5); Mitchell v. C. & P. Stores, 286 F. 2d 109 (CA-5); Mitchell v. E. G. Shinner...

A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

ERIC Educational Resources Information Center

Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

2011-01-01

In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

Forest change in high-elevation forests of Mt. Mitchell, North Carolina: re-census and analysis of data collected over 40 years

Treesearch

Laura Lusk; Matt Mutel; Elaine S. Walker; Foster. Levy

2010-01-01

The Black Mountain range of western North Carolina supports some of the most extensive but threatened high-elevation forests in the southern Appalachians. Of particular note, the insect pathogen, balsam woolly adelgid (Adelges piceae Ratzeburg), has been present on Mt. Mitchell for more than 50 years. In anticipation of potential changes in forest...

Mitchell Red Cloud, Jr., Winnebago Medal of Honor Recipient, 1924-1950. With Teacher's Guide. Native Americans of the Twentieth Century.

ERIC Educational Resources Information Center

Minneapolis Public Schools, MN.

A biography for elementary school students tells about Mitchell Red Cloud, Jr. (Winnebago), an American Indian Army corporal who received a Congressional Medal of Honor for bravery in the Korean War. Photographs of Corporal Red Cloud and his gravesite are included. A teaching guide following the bibliography contains information on the Medal of…

Assess, Coordinate, Execute: How to ACE an Executive Director Search. Issue Brief

ERIC Educational Resources Information Center

Mitchell, Mollie

2011-01-01

This issue brief presents a meaningful strategy for how charter school boards can hire top-notch, well-suited leaders for their schools. Written by Mollie Mitchell, founder and president of The K12 Search Group, this brief is a how-to guide for managing the process of bringing on a new charter school leader. As Ms. Mitchell notes, the only thing…

Further Clarification on the Hom, Mitchell, Lee, and Griffeth (2012) Model: Reply to Bergman, Payne, and Boswell (2012) and Maertz (2012)

ERIC Educational Resources Information Center

Griffeth, Rodger W.; Lee, Thomas W.; Mitchell, Terence R.; Hom, Peter W.

2012-01-01

In this article, we reply to Bergman, Payne, and Boswell (2012) and Maertz (2012), who commented on our reconceptualization of the employee turnover criterion and proximal withdrawal states (Hom, Mitchell, Lee, & Griffeth, 2012). We agree with some points (e.g., anticipated destinations) but take issue with others (e.g., turnover intentions as…

Equilibrium isotope effects on noncovalent interactions in a supramolecular host-guest system.

PubMed

Mugridge, Jeffrey S; Bergman, Robert G; Raymond, Kenneth N

2012-02-01

The self-assembled supramolecular complex [Ga(4)L(6)](12-) (1; L = 1,5-bis[2,3-dihydroxybenzamido]naphthalene) can act as a molecular host in aqueous solution and bind cationic guest molecules to its highly charged exterior surface or within its hydrophobic interior cavity. The distinct internal cavity of host 1 modifies the physical properties and reactivity of bound guest molecules and can be used to catalyze a variety of chemical transformations. Noncovalent host-guest interactions in large part control guest binding, molecular recognition and the chemical reactivity of bound guests. Herein we examine equilibrium isotope effects (EIEs) on both exterior and interior guest binding to host 1 and use these effects to probe the details of noncovalent host-guest interactions. For both interior and exterior binding of a benzylphosphonium guest in aqueous solution, protiated guests are found to bind more strongly to host 1 (K(H)/K(D) > 1) and the preferred association of protiated guests is driven by enthalpy and opposed by entropy. Deuteration of guest methyl and benzyl C-H bonds results in a larger EIE than deuteration of guest aromatic C-H bonds. The observed EIEs can be well explained by considering changes in guest vibrational force constants and zero-point energies. DFT calculations further confirm the origins of these EIEs and suggest that changes in low-frequency guest C-H/D vibrational motions (bends, wags, etc.) are primarily responsible for the observed EIEs. © 2011 American Chemical Society

Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex.

PubMed

Liu, Nan; Higashi, Kenjirou; Ueda, Keisuke; Moribe, Kunikazu

2017-10-15

Various ternary Guest 2/(Guest 1/γ-cyclodextrin (CD)) complexes were prepared using a cogrinding and subsequent heating method, wherein Guest 1 was incorporated in the cavity of γ-CD and Guest 2 was incorporated into the intermolecular spaces between γ-CD columns. Dissolution fluxes of Guest 1 and Guest 2 from all ternary complexes were almost identical. The dissolution flux of flurbiprofen (Guest 1) from the ternary complexes depended on the solubility of Guest 2 drugs (naproxen

Inappropriate publication of trial results and potential for allegations of illegal share dealing.

PubMed

Freestone, D S; Mitchell, H

1993-04-24

There is increasing evidence of fraud in clinical research, and one aspect concerns trading in pharmaceutical company shares by people who may have confidential information about the results of clinical trials. Plainly this has implications for honest investigators, who may find themselves exposed to such allegations. In this paper Dr D S Freestone and Mr H Mitchell, QC, identify three interlinked issues which they think underlie the potential for these allegations. They are pressure for premature or inappropriate communication of research results; trading in pharmaceutical company shares by academic clinical investigators; and the possibility that clinical investigators might succumb to temptation. Dr Freestone and Mr Mitchell suggest that whenever possible results of clinical studies should be published in appropriate medical journals without prior public disclosure. This conflicts with Stock Exchange rules, which require that price sensitive information should be published at the earliest opportunity and preclude priority of publication in medical journals. Freestone and Mitchell believe that rarely rapid public disclosure is acceptable if it is to protect patients' interests but that it must not prejudice publication in the medical or scientific press. When rapid public disclosure is needed, they say, every attempt should be made to inform prescribers before patients. Dr Freestone and Mr Mitchell warn that academic clinical investigators who have access to unpublished price sensitive information about pharmaceutical companies whose shares they trade in will almost certainly be in breach of the Company Securities (Insider Dealing) Act 1985. Furthermore, disclosing such information to third parties, they say, exposes those people also to potential criminal liability. Freestone and Mitchell advise that when potential for allegations of conflict of interest exists clinical investigators should consider declaring their position to ethics committees and any sponsoring organisations.

Inappropriate publication of trial results and potential for allegations of illegal share dealing.

PubMed Central

Freestone, D S; Mitchell, H

1993-01-01

There is increasing evidence of fraud in clinical research, and one aspect concerns trading in pharmaceutical company shares by people who may have confidential information about the results of clinical trials. Plainly this has implications for honest investigators, who may find themselves exposed to such allegations. In this paper Dr D S Freestone and Mr H Mitchell, QC, identify three interlinked issues which they think underlie the potential for these allegations. They are pressure for premature or inappropriate communication of research results; trading in pharmaceutical company shares by academic clinical investigators; and the possibility that clinical investigators might succumb to temptation. Dr Freestone and Mr Mitchell suggest that whenever possible results of clinical studies should be published in appropriate medical journals without prior public disclosure. This conflicts with Stock Exchange rules, which require that price sensitive information should be published at the earliest opportunity and preclude priority of publication in medical journals. Freestone and Mitchell believe that rarely rapid public disclosure is acceptable if it is to protect patients' interests but that it must not prejudice publication in the medical or scientific press. When rapid public disclosure is needed, they say, every attempt should be made to inform prescribers before patients. Dr Freestone and Mr Mitchell warn that academic clinical investigators who have access to unpublished price sensitive information about pharmaceutical companies whose shares they trade in will almost certainly be in breach of the Company Securities (Insider Dealing) Act 1985. Furthermore, disclosing such information to third parties, they say, exposes those people also to potential criminal liability. Freestone and Mitchell advise that when potential for allegations of conflict of interest exists clinical investigators should consider declaring their position to ethics committees and any sponsoring organisations. Images p1113-a p1114-a PMID:8495159

Simulation optimization of spherical non-polar guest recognition by deep-cavity cavitands

PubMed Central

Wanjari, Piyush P.; Gibb, Bruce C.; Ashbaugh, Henry S.

2013-01-01

Biomimetic deep-cavity cavitand hosts possess unique recognition and encapsulation properties that make them capable of selectively binding a range of non-polar guests within their hydrophobic pocket. Adamantane based derivatives which snuggly fit within the pocket of octa-acid deep cavity cavitands exhibit some of the strongest host binding. Here we explore the roles of guest size and attractiveness on optimizing guest binding to form 1:1 complexes with octa-acid cavitands in water. Specifically we simulate the water-mediated interactions of the cavitand with adamantane and a range of simple Lennard-Jones guests of varying diameter and attractive well-depth. Initial simulations performed with methane indicate hydrated methanes preferentially reside within the host pocket, although these guests frequently trade places with water and other methanes in bulk solution. The interaction strength of hydrophobic guests increases with increasing size from sizes slightly smaller than methane to Lennard-Jones guests comparable in size to adamantane. Over this guest size range the preferential guest binding location migrates from the bottom of the host pocket upwards. For guests larger than adamantane, however, binding becomes less favorable as the minimum in the potential-of-mean force shifts to the cavitand face around the portal. For a fixed guest diameter, the Lennard-Jones well-depth is found to systematically shift the guest-host potential-of-mean force to lower free energies, however, the optimal guest size is found to be insensitive to increasing well-depth. Ultimately our simulations show that adamantane lies within the optimal range of guest sizes with significant attractive interactions to match the most tightly bound Lennard-Jones guests studied. PMID:24359375

Apollo 14 Mission image - Astronaut Edgar D. Mitchell, lunar module pilot for the Apollo 14 lunar landing mission, stands by the deployed U.S. flag on the lunar surface during the early moments of the first extravehicular activity (EVA-1) of the mission.

NASA Image and Video Library

1971-02-05

AS14-66-9233 (5 Feb. 1971) --- Astronaut Edgar D. Mitchell, lunar module pilot for the Apollo 14 lunar landing mission, stands by the deployed U.S. flag on the lunar surface during the early moments of the first extravehicular activity (EVA) of the mission. He was photographed by astronaut Alan B. Shepard Jr., mission commander, using a 70mm modified lunar surface Hasselblad camera. While astronauts Shepard and Mitchell descended in the Lunar Module (LM) "Antares" to explore the Fra Mauro region of the moon, astronaut Stuart A. Roosa, command module pilot, remained with the Command and Service Modules (CSM) "Kitty Hawk" in lunar orbit.

Special Section on Synchronization in Nonlinear Science and Engineering

NASA Astrophysics Data System (ADS)

Ikeguchi, Tohru; Tokuda, Isao

Synchronization is a ubiquitous phenomenon of coupled nonlinear oscillators, commonly found in physics, engineering, biology, and other diverse disciplines. It has a long research history back to Christiaan Huygens, who discovered synchronized motion of two pendulum clocks in 1673. It is very easy to observe synchronization in our daily life: e.g., metronomes, candle fires, pet-bottle oscillators, saltwater oscillators, and so on(See, for example, experimental movies at http://www.youtube.com/user/IkeguchiLab?feature=watch). For the last few decades, significant development has been made from both theories and experiments on synchronization of coupled limit cycle oscillators as well as coupled chaotic oscillators. Applications have been also developed to communication technologies, controlling techniques, and data analysis. Combined with the idea from complex network theory, neuroscience, and systems biology, the research speed of synchronization has been even accelerated. This Special Section of NOLTA is primarily dedicated to the recent advanced development of basics and applications of synchronization in science and engineering. A number of qualified works is included, ranging from experimental study on synchronization of Huygens' system, analog circuits, and singing voice to applied study of synchronization in communication networks. One invited paper is devoted to comprehensive reviews on generalized synchronization of chaotic oscillators. On behalf of the editorial committee of the special section, the guest editors would like to express their sincere thanks to all the authors for their excellent contributions. In particular, they are grateful to Prof. Dr. Ulrich Parlitz for contributing his distinguished review article. They would also like to thank the reviewers and the members of the guest editorial committee, especially Prof. Hiroo Sekiya of Chiba University and the editorial staffs of the NOLTA journal, for their supports on publishing this Special Section.

Multiple Authorship in Scientific Manuscripts: Ethical Challenges, Ghost and Guest/Gift Authorship, and the Cultural/Disciplinary Perspective.

PubMed

Teixeira da Silva, Jaime A; Dobránszki, Judit

2016-10-01

Multiple authorship is the universal solution to multi-tasking in the sciences. Without a team, each with their own set of expertise, and each involved mostly in complementary ways, a research project will likely not advance quickly, or effectively. Consequently, there is a risk that research goals will not be met within a desired timeframe. Research teams that strictly scrutinize their modus operandi select and include a set of authors that have participated substantially in the physical undertaking of the research, in its planning, or who have contributed intellectually to the ideas or the development of the manuscript. Authorship is not an issue that is taken lightly, and save for dishonest authors, it is an issue that is decided collectively by the authors, usually in sync with codes of conduct established by their research institutes or national ministries of education. Science, technology and medicine (STM) publishers have, through independent, or sometimes coordinated efforts, also established their own sets of guidelines regarding what constitutes valid authorship. However, these are, for the greater part, merely guidelines. A previous and recent analysis of authorship definitions indicates that the definitions in place regarding authorship and its validity by many leading STM publishers is neither uniform, nor standard, despite several of them claiming to follow the guidelines as set forward by the International Committee of Medical Journal Editors or ICMJE. This disparity extends itself to ghost and guest authorship, two key authorship-related issues that are examined in this paper to assess the extent of discrepancies among the same set of STM publishers and what possible influence they might have on publishing ethics.

A Gold Medal Finish

NASA Technical Reports Server (NTRS)

2003-01-01

During the summer of 1999, Darryl Mitchell of Goddard Space Flight Center's Technology Commercialization Office (TCO) met with the U.S. Olympic Committee at the official training facility in Colorado Springs, Colorado, to offer assistance in transferring NASA technologies applicable to Olympic sports. Following the meeting with the Olympic committee, Mitchell was approached by U.S. Speedskating Long Track Program Director Finn Halvorsen, who eagerly voiced his interest in working with NASA to identify a means of improving performance for his team. According to Halvorsen, 'If (NASA) can put a man on the moon, surely they can help our skaters.' Mitchell and Halvorsen went to work uncovering NASA technologies that could boost the U.S. team's skating capabilities. Mitchell received a crash course in speedskating, and as a result, generated a lengthy list of promising NASA developments that could benefit the sport. From this list, he and his Goddard TCO partner, Joe Famiglietti, deliberated over whether a NASA mirror-polishing technique could possibly be adapted to the athletes speedskates. The polishing technique, developed by Jim Lyons, a 16-year optical engineering veteran of Goddard, was derived from the same principles used to create the optics for NASA's science observatories, such as the Hubble Space Telescope (highly polished optics are required by NASA to obtain sharp, clear images in space).

Validation of reference genes for quantitative real-time PCR during leaf and flower development in Petunia hybrida

PubMed Central

2010-01-01

Background Identification of genes with invariant levels of gene expression is a prerequisite for validating transcriptomic changes accompanying development. Ideally expression of these genes should be independent of the morphogenetic process or environmental condition tested as well as the methods used for RNA purification and analysis. Results In an effort to identify endogenous genes meeting these criteria nine reference genes (RG) were tested in two Petunia lines (Mitchell and V30). Growth conditions differed in Mitchell and V30, and different methods were used for RNA isolation and analysis. Four different software tools were employed to analyze the data. We merged the four outputs by means of a non-weighted unsupervised rank aggregation method. The genes identified as optimal for transcriptomic analysis of Mitchell and V30 were EF1α in Mitchell and CYP in V30, whereas the least suitable gene was GAPDH in both lines. Conclusions The least adequate gene turned out to be GAPDH indicating that it should be rejected as reference gene in Petunia. The absence of correspondence of the best-suited genes suggests that assessing reference gene stability is needed when performing normalization of data from transcriptomic analysis of flower and leaf development. PMID:20056000

CALL FOR PAPERS: Special issue on the random search problem: trends and perspectives

NASA Astrophysics Data System (ADS)

da Luz, Marcos G. E.; Grosberg, Alexander Y.; Raposo, Ernesto P.; Viswanathan, Gandhi M.

2008-11-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to the subject of the random search problem. The motivation behind this special issue is to summarize in a single comprehensive publication, the main aspects (past and present), latest developments, different viewpoints and the directions being followed in this multidisciplinary field. We hope that such a special issue could become a particularly valuable reference for the broad scientific community working with the general random search problem. The Editorial Board has invited Marcos G E da Luz, Alexander Y Grosberg, Ernesto P Raposo and Gandhi M Viswanathan to serve as Guest Editors for the special issue. The general question of how to optimize the search for specific target objects in either continuous or discrete environments when the information available is limited is of significant importance in a broad range of fields. Representative examples include ecology (animal foraging, dispersion of populations), geology (oil recovery from mature reservoirs), information theory (automated researchers of registers in high-capacity database), molecular biology (proteins searching for their sites, e.g., on DNA ), etc. One reason underlying the richness of the random search problem relates to the `ignorance' of the locations of the randomly located `targets'. A statistical approach to the search problem can deal adequately with incomplete information and so stochastic strategies become advantageous. The general problem of how to search efficiently for randomly located target sites can thus be quantitatively described using the concepts and methods of statistical physics and stochastic processes. Scope Thus far, to the best of our knowledge, no recent textbook or review article in a physics journal has appeared on this topic. This makes a special issue with review and research articles attractive to those interested in acquiring a general introduction to the field. The subject can be approached from the perspective of different fields: ecology, networks, transport problems, molecular biology, etc. The study of the problem is particularly suited to the concepts and methods of statistical physics and stochastic processes; for example, fractals, random walks, anomalous diffusion. Discrete landscapes can be approached via graph theory, random lattices and complex networks. Such topics are regularly discussed in Journal of Physics A: Mathematical and Theoretical. All such aspects of the problem fall within the scope and focus of this special issue on the random search problem: trends and perspectives. Editorial policy All contributions to the special issue will be refereed in accordance with the refereeing policy of the journal. In particular, all research papers will be expected to be original work reporting substantial new results. The issue will also contain a number of review articles by invitation only. The Guest Editors reserve the right to judge whether a contribution fits the scope of the special issue. Guidelines for preparation of contributions We aim to publish the special issue in August 2009. To realize this, the DEADLINE for contributed papers is 15 January 2009. There is a page limit of 15 printed pages (approximately 9000 words) per contribution. For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on document preparation can be found at www.iop.org/Journals/jphysa. Contributions to the special issue should if possible be submitted electronically by web upload at www.iop.org/Journals/jphysa, or by email to jphysa@iop.org, quoting 'J. Phys. A Special Issue— Random Search Problem'. Please state whether the paper has been invited or is contributed. Submissions should ideally be in standard LaTeX form. Please see the website for further information on electronic submissions. Authors unable to submit electronically may send hard-copy contributions to: Publishing Administrators, Journal of Physics A, Institute of Physics Publishing, Dirac House, Temple Back, Bristol BS1 6BE, UK, enclosing electronic code on CD if available and quoting 'J. Phys. A Special Issue—Random Search Problem'. All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. This special issue will be published in the paper and online version of the journal. The corresponding author of each contribution will receive a complimentary copy of the issue.

Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes.

PubMed

Tsuchiya, Yuki; Sugikawa, Kouta; Ueda, Masafumi; Ikeda, Atsushi

2017-02-22

The incorporation of hydrophobic guest molecules into lipid membranes by the exchange of the guest molecule from a cyclodextrin (CDx) complex to a liposome is limited to guest molecules that can be included in CDxs. To solve this problem, large guest molecules were incorporated into liposomes by chemical reactions of guest molecules in lipid membranes. Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels-Alder reactions in lipid membranes.

Double level selection in a constitutional dynamic library of coordination driven supramolecular polygons.

PubMed

Rancan, Marzio; Tessarolo, Jacopo; Casarin, Maurizio; Zanonato, Pier Luigi; Quici, Silvio; Armelao, Lidia

2014-07-21

A constitutional dynamic library (CDL) of Cu(II) metallo-supramolecular polygons has been studied as a bench test to examine an interesting selection case based on molecular recognition. Sorting of the CDL polygons is achieved through a proper guest that is hosted into the triangular metallo-macrocycle constituent. Two selection mechanisms are observed, a guest induced path and a guest templated self-assembly (virtual library approach). Remarkably, the triangular host can accommodate several guests with a degree of selectivity ranging from ∼1 to ∼10(4) for all possible guest pairs. A double level selection operates: guests drive the CDL toward the triangular polygon, and, at the same time, this is able to pick a specific guest from a set of competitive molecules, according to a selectivity-affinity correlation. Association constants of the host-guest systems have been determined. Guest competition and exchange studies have been analyzed through variable temperature UV-Vis absorption spectroscopy and single crystal X-ray diffraction studies. Molecular structures and electronic properties of the triangular polygon and of the host-guest systems also have been studied by means of all electrons density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations including dispersive contributions. DFT outcomes ultimately indicate the dispersive nature of the host-guest interactions, while TDDFT results allow a thorough assignment of the host and host-guests spectral features.

Catch the Wave: The Future Is Now. Proceedings of the National Conference of the Association for Media and Technology in Education in Canada (St. John's, Newfoundland, Canada, June 9-12, 1990).

ERIC Educational Resources Information Center

Kennedy, Mary F., Ed.; And Others

The 22 papers in this proceedings were presented at the 1990 Association for Media and Technology in Education in Canada (AMTEC) conference: (1-3) "Selected Quotations" (R. Heinich, D. Beckwith, P. D. Mitchell); (4) "Responses to P. David Mitchell"; (5) "Build It and They Will Come--Creating the 3rd Wave: The Field of…

China in Africa: America’s Soft Power Challenge

DTIC Science & Technology

2011-05-01

22 MCU/CSC/Merrill, T.E./ A Y11 BffiLIOGRAPHY Bergsten, C. Fred, Bates Gill, Nicholas R. Lardy, and Derek Mitchell. China: The Balance Sheet: What...Tiyambe Zeleza. "Africa." World Book Advanced. World Book, 2011. Web. 5 Mar. 2011. Eisenman, Joshua, Eric Heginbotham, and Derek Mitchell, eds. China...docLib/20070726 WhatAfricomMeansforAfrica.pdf. Nye, JosephS. Bound to Lead: The Changing Nature of American Power. New York: Basic Books, 1990. Ong

A revision of the Megachile subgenus Litomegachile Mitchell with an illustrated key and description of a new species (Hymenoptera, Megachilidae, Megachilini)

PubMed Central

Bzdyk, Emily L.

2012-01-01

Abstract The species of Megachile subgenus Litomegachile are revised with a review of the species morphology, biology, and plant associations. A new species, Megachile pankus, is described and illustrated. Megachile mendica snowi Mitchell is elevated to species. Megachile var. nupta Cresson and Megachile texana var. cleomis Cockerell are synonymized with Megachile brevis and Megachile texana, respectively. An illustrated key for Litomegachile is also provided. PMID:23129980

Environment-Dependent Guest Exchange in Supramolecular Hosts

PubMed Central

2015-01-01

Dynamic exchange of guest molecules, encapsulated in host assemblies, is a phenomenon in supramolecular chemistry that has important implications in several applications. While the mechanism of exchange in micellar assemblies has been previously investigated, the effect of host and guest environment upon the guest-exchange dynamics has received little attention, if any. In this paper, we study the guest-exchange mechanism in pH-sensitive nanogels along with pH-insensitive nanogels as a control. By systematically comparing the behavior of these nanogels, we show that size, concentration, and hydrophobicity can all play a critical role in guest-exchange dynamics. More importantly, these studies reveal that the dominant mechanism of guest exchange can intimately depend on environmental factors. PMID:25244305

Responsive Guest Encapsulation of Dynamic Conjugated Microporous Polymers.

PubMed

Xu, Lai; Li, Youyong

2016-06-30

The host-guest complexes of conjugated microporous polymers encapsulating C60 and dye molecules have been investigated systematically. The orientation of guest molecules inside the cavities, have different terms: inside the open cavities of the polymer, or inside the cavities formed by packing different polymers. The host backbone shows responsive dynamic behavior in order to accommodate the size and shape of incoming guest molecule or guest aggregates. Simulations show that the host-guest binding of conjugated polymers is stronger than that of non-conjugated polymers. This detailed study could provide a clear picture for the host-guest interaction for dynamic conjugated microporous polymers. The mechanism obtained could guide designing new conjugated microporous polymers.

A tutorial for software development in quantitative proteomics using PSI standard formats☆

PubMed Central

Gonzalez-Galarza, Faviel F.; Qi, Da; Fan, Jun; Bessant, Conrad; Jones, Andrew R.

2014-01-01

The Human Proteome Organisation — Proteomics Standards Initiative (HUPO-PSI) has been working for ten years on the development of standardised formats that facilitate data sharing and public database deposition. In this article, we review three HUPO-PSI data standards — mzML, mzIdentML and mzQuantML, which can be used to design a complete quantitative analysis pipeline in mass spectrometry (MS)-based proteomics. In this tutorial, we briefly describe the content of each data model, sufficient for bioinformaticians to devise proteomics software. We also provide guidance on the use of recently released application programming interfaces (APIs) developed in Java for each of these standards, which makes it straightforward to read and write files of any size. We have produced a set of example Java classes and a basic graphical user interface to demonstrate how to use the most important parts of the PSI standards, available from http://code.google.com/p/psi-standard-formats-tutorial. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. PMID:23584085

The amino acid's backup bone - storage solutions for proteomics facilities.

PubMed

Meckel, Hagen; Stephan, Christian; Bunse, Christian; Krafzik, Michael; Reher, Christopher; Kohl, Michael; Meyer, Helmut Erich; Eisenacher, Martin

2014-01-01

Proteomics methods, especially high-throughput mass spectrometry analysis have been continually developed and improved over the years. The analysis of complex biological samples produces large volumes of raw data. Data storage and recovery management pose substantial challenges to biomedical or proteomic facilities regarding backup and archiving concepts as well as hardware requirements. In this article we describe differences between the terms backup and archive with regard to manual and automatic approaches. We also introduce different storage concepts and technologies from transportable media to professional solutions such as redundant array of independent disks (RAID) systems, network attached storages (NAS) and storage area network (SAN). Moreover, we present a software solution, which we developed for the purpose of long-term preservation of large mass spectrometry raw data files on an object storage device (OSD) archiving system. Finally, advantages, disadvantages, and experiences from routine operations of the presented concepts and technologies are evaluated and discussed. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. Copyright © 2013. Published by Elsevier B.V.

Critical ethnography: An under-used research methodology in neuroscience nursing.

PubMed

Ross, Cheryl; Rogers, Cath; Duff, Diane

2016-01-01

Critical ethnography is a qualitative research method that endeavours to explore and understand dominant discourses that are seen as being the 'right' way to think, see, talk about or enact a particular 'action' or situation in society and recommend ways to re-dress social power inequities. In health care, vulnerable populations, including many individuals who have experienced neurological illnesses or injuries that leave them susceptible to the influence of others, would be suitable groups for study using critical ethnography methodology. Critical ethnography has also been used to study workplace culture. While ethnography has been effectively used to underpin other phenomena of interest to neuroscience nurses, only one example of the use of critical ethnography exists in the published literature related to neuroscience nursing. In our "Research Corner" in this issue of the Canadian Journal of Neuroscience Nursing (CJNN) our guest editors, Dr. Cheryl Ross and Dr. Cath Rogers will briefly highlight the origins of qualitative research, ethnography, and critical ethnography and describe how they are used and, as the third author, I will discuss the relevance of critical ethnography findings for neuroscience nurses.

Virtual reality and physical rehabilitation: a new toy or a new research and rehabilitation tool?

PubMed Central

Keshner, Emily A

2004-01-01

Virtual reality (VR) technology is rapidly becoming a popular application for physical rehabilitation and motor control research. But questions remain about whether this technology really extends our ability to influence the nervous system or whether moving within a virtual environment just motivates the individual to perform. I served as guest editor of this month's issue of the Journal of NeuroEngineering and Rehabilitation (JNER) for a group of papers on augmented and virtual reality in rehabilitation. These papers demonstrate a variety of approaches taken for applying VR technology to physical rehabilitation. The papers by Kenyon et al. and Sparto et al. address critical questions about how this technology can be applied to physical rehabilitation and research. The papers by Sveistrup and Viau et al. explore whether action within a virtual environment is equivalent to motor performance within the physical environment. Finally, papers by Riva et al. and Weiss et al. discuss the important characteristics of a virtual environment that will be most effective for obtaining changes in the motor system. PMID:15679943

Structure-activity relationships in carbohydrates revealed by their hydration.

PubMed

Maugeri, Laura; Busch, Sebastian; McLain, Sylvia E; Pardo, Luis Carlos; Bruni, Fabio; Ricci, Maria Antonietta

2017-06-01

One of the more intriguing aspects of carbohydrate chemistry is that despite having very similar molecular structures, sugars have very different properties. For instance, there is a sensible difference in sweet taste between glucose and trehalose, even though trehalose is a disaccharide that comprised two glucose units, suggesting a different ability of these two carbohydrates to bind to sweet receptors. Here we have looked at the hydration of specific sites and at the three-dimensional configuration of water molecules around three carbohydrates (glucose, cellobiose, and trehalose), combining neutron diffraction data with computer modelling. Results indicate that identical chemical groups can have radically different hydration patterns depending on their location on a given molecule. These differences can be linked with the specific activity of glucose, cellobiose, and trehalose as a sweet substance, as building block of cellulose fiber, and as a bioprotective agent, respectively. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader. Copyright © 2016 Elsevier B.V. All rights reserved.

Selected contributions from the 9th International Conference on Tidal Sedimentology, November 2015, Puerto Madryn, Patagonia, Argentina: an introduction

NASA Astrophysics Data System (ADS)

Scasso, Roberto A.; Cuitiño, José I.

2017-08-01

This special issue of Geo-Marine Letters presents selected contributions from the 9th International Conference on Tidal Sedimentology held on 17-19 November 2015 in Puerto Madryn, Chubut Province, Patagonia, Argentina. The guest editors are the conference organizers Roberto A. Scasso and José I. Cuitiño. Gerardo M. Perillo was the head of the Scientific Committee. The conferences on tidal sedimentology have been traditionally held every 4 years. However, only 3 years separated the last conference held in Caen (France, 2012) from this conference. Increasing numbers of contributions and the growing interest in tidal sedimentation have been the reasons for shortening the inter-conference period. The 2015 conference served as a discussion forum focusing on advances in modern and ancient tidal sedimentation at different locations worldwide. The papers presented in this Special Issue provide a selective view of the latest research results, the main topics dealing with tidal hydrodynamics and sediment transport, tidal coastal morphodynamics, modern and ancient tidal sedimentation, geotechnical processes in tidal environments, and tidal basins, facies and reservoirs.

Multifaceted plasma membrane Ca(2+) pumps: From structure to intracellular Ca(2+) handling and cancer.

PubMed

Padányi, Rita; Pászty, Katalin; Hegedűs, Luca; Varga, Karolina; Papp, Béla; Penniston, John T; Enyedi, Ágnes

2016-06-01

Plasma membrane Ca(2+) ATPases (PMCAs) are intimately involved in the control of intracellular Ca(2+) concentration. They reduce Ca(2+) in the cytosol not only by direct ejection, but also by controlling the formation of inositol-1,4,5-trisphosphate and decreasing Ca(2+) release from the endoplasmic reticulum Ca(2+) pool. In mammals four genes (PMCA1-4) are expressed, and alternative RNA splicing generates more than twenty variants. The variants differ in their regulatory characteristics. They localize into highly specialized membrane compartments and respond to the incoming Ca(2+) with distinct temporal resolution. The expression pattern of variants depends on cell type; a change in this pattern can result in perturbed Ca(2+) homeostasis and thus altered cell function. Indeed, PMCAs undergo remarkable changes in their expression pattern during tumorigenesis that might significantly contribute to the unbalanced Ca(2+) homeostasis of cancer cells. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen. Copyright © 2015 Elsevier B.V. All rights reserved.

Learning through social interaction in game technology.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waern, Annika; Raybourn, Elaine Marie

2005-05-01

The present ITSE journal special issue on 'Learning About Social Interaction through Gaming' is the result of an invitation to the attendees of a one-day workshop on 'Social Learning Through Gaming' co-organized by the guest editors and held at the Human Factors in Computing Systems (CHI) conference on April 26, 2004 in Vienna, Austria. CHI is one of the premiere conferences on human-computer interaction. CHI 2004 attracted hundreds of delegates from all over the world. The CHI workshop program results from a competitive selection process. The Social Learning through Gaming workshop was filled to capacity and attended by approximately 25more » participants from Europe and North America who submitted position papers that were refereed and selected for participation based on the relevancy and innovativeness of the research. The participants came together to share research on play, learning, games, interactive technologies, and what playing and designing games can teach us about social behaviors. The present special issue focuses on learning about social aspects through gaming: learning to socialize through games and learning games through social behavior.« less

Electronegative Guests in CoSb 3

DOE PAGES

Duan, Bo; Yang, Jiong; Salvador, James R.; ...

2016-04-19

Introducing guests into a host framework to form a so called inclusion compound can be used to design materials with new and fascinating functionalities. The vast majority of inclusion compounds have electropositive guests with neutral or negatively charged frameworks. Here, we show a series of electronegative guest filled skutterudites with inverse polarity. The strong covalent guest-host interactions observed for the electronegative group VIA guests, i.e., S and Se, feature a unique localized cluster vibration which significantly influences the lattice dynamics, together with the point-defect scattering caused by element substitutions, resulting in very low lattice thermal conductivity values. The findings ofmore » electronegative guests provide a new perspective for guest-filling in skutterudites, and the covalent filler/lattice interactions lead to an unusual lattice dynamics phenomenon which can be used for designing high-efficiency thermoelectric materials and novel functional inclusion compounds with open structures.« less

EDITORIAL: 50th anniversary issue

NASA Astrophysics Data System (ADS)

Beddoe, Alun H.

2006-07-01

In July 1956, 50 years ago, the first issue of Physics in Medicine and Biology (PMB) was published. It was subtitled The Journal of the Hospital Physicists' Association and published in association with the Philosophical Magazine by Taylor and Francis. Subscriptions were £1 per part or £3 10s for an annual subscription. The Editor, Professor J E Roberts, prefaced the first issue with a cautious editorial noting: The appearance of a new journal is usually greeted with mixed feelings by scientific workers, a common response being that there are far too many journals already. Justification for a new publication is only possible if there is a clearly defined gap in the publishing facilities available to workers in a particular scientific field.... Professor Roberts ended by seeking support from the scientific community for the new venture. He certainly got it! From a tentative few hundred pages in four issues a year for the first few years, the journal is now issued twice monthly with nearly 8000 pages expected in volume 51. In this anniversary issue we have invited some 28 senior authors to submit papers on a range of subjects spanning the discipline. We decided that to be an author one had to be old, but age was not to be the only criterion! Indeed readers will recognize all names as major contributors to both the development of medical physics and the success of PMB. Authors were not asked to write formal topical reviews of the state-of-the-art of the sub-disciplines which make up medical physics, but rather to present short historical reviews, didactic in style, perhaps highlighting the role of PMB in the development of their fields. Nevertheless, other than a page limit (which many subsequently ignored!) no formal format was imposed on authors, so what follows is a range of contributions from the almost conversational, personal statement to the more formal and familiar scientific paper. Whatever the writing style we are confident that readers will gain some appreciation of the development of our wide-ranging discipline over the last half century. Some readers may feel that one or two subjects have not been represented, and for that I can only apologise. We did ask for contributions to several other topics (for example radiation metrology and optical techniques) but inevitably there were authors who for various reasons were unable to meet the deadline. Inevitably we will also have missed contributions from excellent potential authors (who satisfied the age criterion!). As Guest Editor I must bear the responsibility for those omissions. While page limits do not permit me to discuss the contributions to this issue individually I would like to mention the first contribution by Dr J E (Bob) Burns. Dr Burns was on the Editorial Board in the early sixties working with the second Editor, Professor Sir Joseph Rotblat. Both in his article and in personal communications Dr Burns has emphasized the important role of Professor Rotblat in the early years. I did write to Professor Rotblat seeking a contribution from him but, sadly, received a reply saying that he was not well enough to contribute `at present'; he died a few weeks later at the age of 96 years (please refer to www.pugwash.org for tributes from Mikhail Gorbachev, Kofi Annan and many others). Dr Burns wrote a short note to me shortly after his death including the following comment which is reproduced below: Although many people have contributed to the success of PMB over the last 50 years it was Rotblat's restless energy, power of persuasion and already existing fame (he was well known both scientifically and to the public at the time) that enabled him to rescue the journal from an early death. After discussions with colleagues around the UK, including Dr Burns, and with the Editorial Board, we all felt that it would be highly appropriate to dedicate this anniversary issue to the memory of Professor Rotblat. Institute of Physics Publishing (IOP) took over the publishing of PMB in 1972, firstly on behalf of the Hospital Physicists' Association and then on behalf of the Institute of Physics and Engineering in Medicine (IPEM). I wish to pay tribute to the staff at the IOP Publishing Office for the continuing excellent quality and short publication times for articles appearing in PMB. There can be no doubt that this contributes to the popularity with authors and readers alike. It almost goes without saying but I should also thank all the contributors, referees, Editorial Board members and International Advisory Board members who have, collectively, made PMB the success that it is. For historical interest I list below the 11 editors of PMB since its inception. Three of these editors have contributed papers to this issue. 1956-1961 Professor J E Roberts, Middlesex Hospital, London 1961-1972 Professor Sir Joseph Rotblat, St Bartholomew's Hospital, London 1973-1978 Professor H A B Simons, Royal Free Hospital, London 1979-1982 Mr J Clifton, University College Hospital, London 1983-1985 Professor R P Parker, University of Leeds, Leeds 1986-1987 Dr M J Day, Newcastle General Hospital, Newcastle 1988-1991 Professor S C Lillicrap, Royal United Hospital, Bath 1992-1995 Professor B L Diffey, Dryburn Hospital, Durham 1996-1999 Professor M O Leach, Royal Marsden NHS Foundation Trust, London 2000-2005 Professor A H Beddoe, University Hospital, Birmingham 2006- Professor S Webb, Royal Marsden NHS Foundation Trust, London Finally, apart from noting the usual caveat that the Guest Editor, Editor-in Chief, IOP and IPEM take no responsibility for opinions expressed by authors, I would like to conclude by wishing Professor Steve Webb and future editors every success. While I may not be around for the centenary issue in July 2056 I have every reason to believe that it will be a good one.

Coilable Crystalline Fiber (CCF) Lasers and their Scalability

DTIC Science & Technology

2014-03-01

Fibers: Double-Clad Design Concept of Tm:YAG-Core Fiber and Mode Simulation. Proc. SPIE 2012, 8237 , 82373M. 8. Beach, R. J.; Mitchell, S. C...Dubinskii, M. True Crystalline Fibers: Double-Clad LMA Design Concept of Tm:YAG-Core Fiber and Mode Simulation. Proc. of SPIE 2012, 8237 , 82373M-1...Tm:YAG-Core Fiber and Mode Simulation. Proc. SPIE 8237 , 82373M, 2012. 8. Beach, R. J.; Mitchell, S. C.; Meissner, H. E.; Meissner, O. R.; Krupke, W

Air Force UAV’s: The Secret History

DTIC Science & Technology

2010-07-01

iA Mitchell Institute Study i Air Force UAVs The Secret History A Mitchell Institute Study July 2010 By Thomas P. Ehrhard Report Documentation Page...DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Air Force UAVs The Secret History 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c... The Secret History 2 Air Force UAVs: The Secret History2 air Force uaVs: The secret history Has any airplane in the past decade captured the public

North to Alaska: The Geostrategic Importance of the Last Frontier

DTIC Science & Technology

2012-06-01

Alaskan and Round- the -World Flights-December 1919,” Mitchell L / C Box 7, AFHRA, Maxwell AFB AL. 7 Mitchell, The Strategic Key to the World, 3. 8 Cloe...Army Air Corps Record in Flying the Mail,” MICFILM 43796, IRIS #01102971, Foulois L / C Box 14, in the Murray Green Papers, AFHRA, Maxwell AFB AL...Coverage,” MICFILM 43796, IRIS #01102971, L / C Box 262, in the Murray Green Papers, AFHRA, Maxwell AFB AL. 72 “Alaskan Flight: Arnold’s Report

Dragooned into a Joint War: American Airpower in the Mediterranean and Operation Dragoon

DTIC Science & Technology

2009-06-01

nearly as old as the airplane. While many wish to focus on early airpower zealots such as Douhet, Trenchard, and Mitchell for proof of a parochial...for solutions to the trench stalemate. Airmen felt they could now fashion, according to theorists such as Douhet, Trenchard, and Mitchell , quick and...61 This chapter is based on the following works: Jeffery J. Clark and Robert Ross Smith , United States Army in World War II, The European Theatre

Nonlinear Relationships Between Particulate Absorption and Chlorophyll: Detritus or Pigment Packaging

DTIC Science & Technology

1993-06-15

for another polar area. For samples from Antartic waters, the mean a*pan(4 3 5 ), normalized to chl a + pheo, was 0.0 18 m2 (mg chl a)-I (Mitchell and...specific absorption coefficients, was suggested as the cause of relatively low mean specific absorption coefficients in the Antartic . The values of c1...moored optical sensors in the Sargasso Sea. J. Geophys. Res. 97, 7399-7412. Mitchell, B.G., and 0. Holm-Hansen 1991. Bio-optical properties of Antartic

Artist's concept of Apollo 14 crewmen on their firs traverse of lunar surface

NASA Image and Video Library

1971-01-11

S71-16101 (January 1971) --- A Grumman Aerospace Corporation artist's concept of Apollo 14 crewmen, astronauts Alan B. Shepard Jr., commander, and Edgar D. Mitchell, lunar module pilot, as they set out on their first traverse. Shepard is pulling the Modularized Equipment Transporter (MET) which contains cameras, lunar sample bags, tools and other paraphernalia. Shepard has the Laser Ranging Retro-Reflector (LR-3) in his other hand. Mitchell is carrying the Apollo Lunar Surface Experiments Package (ALSEP) barbell mode.

Atomic Processes Relevant to Antimatter Fuel Production and Storage

DTIC Science & Technology

1994-05-31

TO ANTIMATTER FUEL ’ |PRODUCTION AND STORAGE DTIC S nELECTE JUL0 11994 D FINAL REPORT F * 31 MAY 1994 I * Prepared by: J.B.A. Mitchell Dept. of Physics...Atomic Processes Relevant to Antimatter Fuel Production and Storage 12. PERSONAL AUTHOR(S) J.B.A. Mitchell I 3a. TYPE JFRE qT 113b. TIME COVERED 114... antimatter production, this investigation did shed a great deal of light on the recombination process in general and so is worthy of inclusion in this report

Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, thermal energy transfer assemblies, and methods for transferring thermal energy

DOEpatents

McGrail, B. Peter; Brown, Daryl R.; Thallapally, Praveen K.

2016-08-02

Methods for releasing associated guest materials from a metal organic framework are provided. Methods for associating guest materials with a metal organic framework are also provided. Methods are provided for selectively associating or dissociating guest materials with a metal organic framework. Systems for associating or dissociating guest materials within a series of metal organic frameworks are provided. Thermal energy transfer assemblies are provided. Methods for transferring thermal energy are also provided.

Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, thermal energy transfer assemblies, and methods for transferring thermal energy

DOEpatents

McGrail, B. Peter; Brown, Daryl R.; Thallapally, Praveen K.

2014-08-05

Methods for releasing associated guest materials from a metal organic framework are provided. Methods for associating guest materials with a metal organic framework are also provided. Methods are provided for selectively associating or dissociating guest materials with a metal organic framework. Systems for associating or dissociating guest materials within a series of metal organic frameworks are provided. Thermal energy transfer assemblies are provided. Methods for transferring thermal energy are also provided.

Quantitative analysis of the guest-concentration dependence of the mobility in a disordered fluorene-arylamine host-guest system in the guest-to-guest regime

NASA Astrophysics Data System (ADS)

Nicolai, H. T.; Hof, A. J.; Lu, M.; Blom, P. W. M.; de Vries, R. J.; Coehoorn, R.

2011-11-01

The charge transport in a polyspirobifluorene derivative with copolymerized N,N,N',N'-tetraaryldiamino biphenyl (TAD) hole transport units is investigated as a function of the TAD content. For TAD concentrations larger than 5%, guest-to-guest transport is observed. It is demonstrated that in this regime the charge carrier density dependent mobility can be described consistently with the extended Gaussian disorder model, with a density of hopping sites which is proportional to the TAD concentration and comparable to the molecular density.

The analysis of creep characteristics of the surrounding rock of the carbonaceous rock tunnel based on Singh-Mitchell model

NASA Astrophysics Data System (ADS)

Luo, Junhui; Mi, Decai; Ye, Qiongyao; Deng, Shengqiang; Zeng, Fuquan; Zeng, Yongjun

2018-01-01

Carbonaceous rock has the characteristics of easy disintegration, softening, swelling and environmental sensitivity, which belongs to soft surrounding rock, and the deformation during excavation and long-term stability of the surrounding rock of carbonaceous rock tunnel are common problems in the construction of carbonaceous rock tunnel. According to the above, the Monitor and measure the displacement, temperature and osmotic pressure of the surrounding carbonaceous rock of the tunnel of Guangxi Hebai highway. Then it based on the obtaining data to study the creep mechanism of surrounding rock using Singh-Mitchell model and predict the deformation of surrounding rock before the tunnel is operation. The results show that the Singh-Mitchell creep model can effectively analyse and predict the deformation development law of surrounding rock of tunnel without considering temperature and osmotic pressure, it can provide reference for the construction of carbonaceous rock tunnel and the measures to prevent and reinforce it..

Civil war medicine from the perspective of S. Weir Mitchell's "The case of George Dedlow".

PubMed

Canale, D J

2002-03-01

In 1866, a year following the close of the American Civil War, an anonymous article arousing much public interest appeared in the popular magazine, The Atlantic Monthly. The real author, Silas Weir Mitchell, who became one of America's most distinguished neurologists, wrote this short story early in his career while serving as a contract army surgeon and conducting his important clinical researches in nerve injuries. This article was the first literary effort in his long and prolific career as a physician/writer. Historians citing this article have focused almost exclusively on the early descriptions of causalgia and phantom limb syndrome, appearing as it did in a popular magazine. The present author proposes to show, for the first time, that Mitchell actually intended to describe many important medical consequences of the American Civil War, which was later shown to have so profoundly affected him throughout his medical and literary career. He cleverly accomplished this through the narration of Assistant Surgeon George Dedlow, who loses all four extremities by amputation.

A molecular dynamics study of model SI clathrate hydrates: the effect of guest size and guest-water interaction on decomposition kinetics.

PubMed

Das, Subhadip; Baghel, Vikesh Singh; Roy, Sudip; Kumar, Rajnish

2015-04-14

One of the options suggested for methane recovery from natural gas hydrates is molecular replacement of methane by suitable guests like CO2 and N2. This approach has been found to be feasible through many experimental and molecular dynamics simulation studies. However, the long term stability of the resultant hydrate needs to be evaluated; the decomposition rate of these hydrates is expected to depend on the interaction between these guest and water molecules. In this work, molecular dynamics simulation has been performed to illustrate the effect of guest molecules with different sizes and interaction strengths with water on structure I (SI) hydrate decomposition and hence the stability. The van der Waals interaction between water of hydrate cages and guest molecules is defined by Lennard Jones potential parameters. A wide range of parameter spaces has been scanned by changing the guest molecules in the SI hydrate, which acts as a model gas for occupying the small and large cages of the SI hydrate. All atomistic simulation results show that the stability of the hydrate is sensitive to the size and interaction of the guest molecules with hydrate water. The increase in the interaction of guest molecules with water stabilizes the hydrate, which in turn shows a slower rate of hydrate decomposition. Similarly guest molecules with a reasonably small (similar to Helium) or large size increase the decomposition rate. The results were also analyzed by calculating the structural order parameter to understand the dynamics of crystal structure and correlated with the release rate of guest molecules from the solid hydrate phase. The results have been explained based on the calculation of potential energies felt by guest molecules in amorphous water, hydrate bulk and hydrate-water interface regions.

Looking back at the John Mitchell Crouch Fellowship: the most prestigious research award of the Royal Australasian College of Surgeons.

PubMed

Boult, Margaret; Babidge, Wendy; Pleass, Susan; Scott, David

2015-10-01

The John Mitchell Crouch Fellowship is a generous endowment made to the Royal Australasian College of Surgeons (RACS) by the young neurosurgeon's family, following his death from a brain tumour. In this article, we examine the significance and legacy of the grant since its inception in 1979. This is the highest level of research fellowship awarded by the RACS recognizing early career excellence, as part of its significant research funding programme (over $1.7 million in 2015). John Mitchell Crouch recipients have been pioneers in various areas of medicine where they have developed new technologies, established research centres, improved patient safety and military surgery and embraced evidence-based medicine. The funds they received have directly contributed to research published in numerous highly respected peer-reviewed journals such as The New England Journal of Medicine; established new laboratories, helped fund clinical trials and allowed new directions of research to be pursued. Recipients of the John Mitchell Crouch Fellowship have been recognized with many awards including 11 Australian and New Zealand Honours to date. Many other significant research funds have been subsequently bestowed, including over 120 National Health Medical Research Council (NHMRC) grants to Australian and New Zealand recipients subsequent to their Fellowship. This article also shows the range of disciplines in which the award has supported cutting-edge research leading to benefits for patients and health care. © 2015 Royal Australasian College of Surgeons.

Third report on the Oak Ridge K-25 Site Biological Monitoring and Abatement Program for Mitchell Branch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinzman, R.L.; Adams, S.M.; Ashwood, T.L.

1995-08-01

As a condition of the modified National Pollutant Discharge Elimination System (NPDES) permit issued to the Oak Ridge Gaseous Diffusion Plant (ORGDP; now referred to as the Oak Ridge K-25 Site) on September 11, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream (Mitchell Branch or K-1700 stream). On October 1, 1992, a renewed NPDES permit was issued for the K-25 Site. A biological monitoring plan was submitted for Mitchell Branch, Poplar Creek, Poplar Creek Embayment of the Clinch River and any unnamed tributaries of these streams. The objectives of BMAP are to (1) demonstratemore » that the effluent limitations established for the Oak Ridge K-25 Site protect and maintain the use of Mitchell Branch for growth and propagation of fish and other aquatic life and (2) document the effects on stream biota resulting from operation of major new pollution abatement facilities, including the Central Neutralization Facility (CNF) and the Toxic Substances Control Act (TSCA) incinerator. The BMAP consists of four tasks: (1) toxicity monitoring; (2) bioaccumulation monitoring; (3) assessment of fish health; and (4) instream monitoring of biological communities, including benthic macroinvertebrates and fish. This document, the third in a series, reports on the results of the Oak Ridge K-25 Site BMAP; it describes studies that were conducted over various periods of time between June 1990 and December 1993, although monitoring conducted outside this time period is included, as appropriate.« less

Binding of chemical warfare agent simulants as guests in a coordination cage: contributions to binding and a fluorescence-based response.

PubMed

Taylor, Christopher G P; Piper, Jerico R; Ward, Michael D

2016-05-07

Cubic coordination cages act as competent hosts for several alkyl phosphonates used as chemical warfare agent simulants; a range of cage/guest structures have been determined, contributions to guest binding analysed, and a fluorescent response to guest binding demonstrated.

Mitchells Over the Pacific: The Dynamics of B-25 Innovation

DTIC Science & Technology

2013-06-01

began modifying the B- 25 to increase its self -defense capability. The B-25B was the version employed by the Army Air Forces (AAF) during its first...guns in the nose, waist, and floor along with a .50-caliber machine gun in the tail.31 Internally, the B-25A added armor for the aircrew and self ...Forces in World War II, vol. 1, 439. 50 Doyle, B-25 Mitchell, 10. 19 within the aircraft with a 160-gallon rubber fuel bag and ten five-gallon fuel

Astronauts Shepard and Mitchell practice using Active Seismic Experiment

NASA Image and Video Library

1970-10-30

S71-15273 (October 1970) --- Apollo 14 astronauts Alan B. Shepard Jr., commander (right); and Edgar D. Mitchell, lunar module pilot, practice using the Active Seismic Experiment (ASE) to set off explosions on the lunar surface and arm a mortar to launch four grenades after they leave. Measurements of the ensuing vibrations of the moon, radioed to Earth, will give scientists new information on the shape, structure and thickness of the outer lunar crust. ASE will be deployed during one of two Apollo 14 extravehicular activity (EVA) periods.

Aniline-containing guests recognized by α,α',δ,δ'-tetramethyl-cucurbit[6]uril host.

PubMed

Lin, Rui-Lian; Fang, Guo-Sheng; Sun, Wen-Qi; Liu, Jing-Xin

2016-12-13

The host-guest complexation of symmetrical α,α',δ,δ'-tetramethyl-cucurbit[6]uril (TMeQ[6]) and cucurbit[7]uril (Q[7]) with a series of aniline-containing guests has been investigated by various experimental techniques including NMR, ITC, and X-ray crystallography. Experimental results indicate that both TMeQ[6] and Q[7] hosts can encapsulate aniline-containing guests to form stable inclusion complexes. However, the oval cavity of TMeQ[6] is more complementary in size and shape to the aromatic ring of the guests than the spherical cavity of Q[7]. Shielding and deshielding effects of the aromatic ring on guests lead to the remarkable chemical shifts of the TMeQ[6] host protons. The rotational restriction of the guests in the oval cavity of TMeQ[6] results in the large negative values of entropy. The X-ray crystal structure of the 1:1 inclusion complex between TMeQ[6] and N,N'-diethyl-benzene-1,4-diamine unambiguously reveals that the aromatic ring of the guest resides in the oval cavity of TMeQ[6].

Nurses as 'guests'--a study of a concept in light of Jacques Derrida's philosophy of hospitality.

PubMed

Oresland, Stina; Lutzén, Kim; Norberg, Astrid; Rasmussen, Birgit H; Määttä, Sylvia

2013-04-01

As revealed in previous empirical research, nurses describe their position in home-based nursing care (HBNC) as that of 'guests' in the patient's home. Such a description is problematic as 'guests' might not be considered to belong to the realm of professionalism. As Jacques Derrida's work on hospitality has received wide publicity, sparking theoretical and philosophical discussion about host and guest, the aim of this study was to explore how the concept 'guests' can be understood in the light of Derrida's philosophy of hospitality. The study revealed that (a) guest must be considered a binary concept; and (b) hospitality should be regarded as an exchange of giving and receiving between a host and a guest. The present study demonstrated that it is important to reflect on the meaning of the concepts used by nurses in HBNC. Further theoretical and empirical exploration of the concept 'hospitality' would be fruitful, i.e. what is patients' understanding of 'hospitality' and 'hostility' related to nurses' descriptions of themselves as 'guests' in the patient's home. © 2013 Blackwell Publishing Ltd.

PPII propensity of multiple-guest amino acids in a proline-rich environment.

PubMed

Moradi, Mahmoud; Babin, Volodymyr; Sagui, Celeste; Roland, Christopher

2011-07-07

There has been considerable debate about the intrinsic PPII propensity of amino acid residues in denatured polypeptides. Experimentally, this scale is based on the behavior of guest amino acid residues placed in the middle of proline-based hosts. We have used classical molecular dynamics simulations combined with replica-exchange methods to carry out a comprehensive analysis of the conformational equilibria of proline-based host oligopeptides with multiple guest amino acids including alanine, glutamine, valine, and asparagine. The tracked structural characteristics include the secondary structural motifs based on the Ramachandran angles and the cis/trans isomerization of the prolyl bonds. In agreement with our recent study of single amino acid guests, we did not observe an intrinsic PPII propensity in any of the guest amino acids in a multiple-guest setting. Instead, the experimental results can be explained in terms of (i) the steric restrictions imposed on the C-terminal guest amino acid that is immediately followed by a proline residue and (ii) an increase in the trans content of the prolyl bonds due to the presence of guest residues. In terms of the latter, we found that the more guests added to the system, the larger the increase in the trans content of the prolyl bonds, which results in an effective increase in the PPII content of the peptide.

Nucleation pathways of clathrate hydrates: effect of guest size and solubility.

PubMed

Jacobson, Liam C; Hujo, Waldemar; Molinero, Valeria

2010-11-04

Understanding the microscopic mechanism of nucleation of clathrate hydrates is important for their use in hydrogen storage, CO(2) sequestration, storage and transport of natural gas, and the prevention of the formation of hydrate plugs in oil and gas pipelines. These applications involve hydrate guests of varied sizes and solubility in water that form different hydrate crystal structures. Nevertheless, molecular studies of the mechanism of nucleation of hydrates have focused on the single class of small hydrophobic guests that stabilize the sI crystal. In this work, we use molecular dynamics simulations with a very efficient coarse-grained model to elucidate the mechanisms of nucleation of clathrate hydrates of four model guests that span a 2 orders of magnitude range in solubility in water and that encompass sizes which stabilize each one a different hydrate structure (sI and sII, with and without occupancy of the dodecahedral cages). We find that the overall mechanism of clathrate nucleation is similar for all guests and involves a first step of formation of blobs, dense clusters of solvent-separated guest molecules that are the birthplace of the clathrate cages. Blobs of hydrophobic guests are rarer and longer-lived than those for soluble guests. For each guest, we find multiple competing channels to form the critical nuclei, filled dodecahedral (5(12)) cages, empty 5(12) cages, and a variety of filled large (5(12)6(n) with n = 2, 3, and 4) clathrate cages. Formation of empty dodecahedra is an important nucleation channel for all but the smallest guest. The empty 5(12) cages are stabilized by the presence of guests from the blob in their first solvation shell. Under conditions of high supercooling, the structure of the critical and subcritical nuclei is mainly determined by the size of the guest and does not reflect the cage composition or ordering of the stable or metastable clathrate crystals.

Synthesis of Cyclic Porphyrin Trimers through Alkyne Metathesis Cyclooligomerization and Their Host–Guest Binding Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Chao; Long, Hai; Jin, Yinghua

2016-06-17

Cyclic porphyrin trimers were synthesized through one-step cyclooligomerization via alkyne metathesis from diyne monomers. These macrocycles show interesting host-guest binding interactions with fullerenes, selectively binding C70 (6 x 103 M-1) over C60 and C84 (no binding observed). The fullerene-encapsulated host-guest complex can undergo guest or host exchange in the presence of another guest (2,4,6-tri(4-pyridyl)-1,3,5-triazine) or host (cage COP5) molecule with higher binding affinity.

Hydrogen bonding assemblies in host guest complexes with 18-crown-6

NASA Astrophysics Data System (ADS)

Fonari, M. S.; Simonov, Yu. A.; Kravtsov, V. Ch.; Lipkowski, J.; Ganin, E. V.; Yavolovskii, A. A.

2003-02-01

Recent X-ray crystal structural data for two novel 1:2 host-guest complexes of 18-crown-6 with neutral organic molecules, thiaamide hydrazide of 2-aminobenzoic acid and thiaamide hydrazide of 4-amino-1,2,5-thiadiazole-3-carbonic acid are reported. The supramolecular structures of these two and five relative complexes are discussed from the point of view of participation of donor groups in coordination with the crown ether, and donor and acceptor groups in the self-assembly of the guest molecules. Guest molecules have incorporated amine and hydrazine moieties as proton donors and carbonyl oxygen and sulfur (in thiadiazole and in thiaamine moieties) as proton acceptors. The guest-guest interactions appeared to be crucial in the final architecture.

Quality of customer service: perceptions from guests in all-inclusive resorts in Jamaica

Treesearch

Joel L. Frater

2007-01-01

With data collected from guests in all-inclusive resorts in Jamaica, West Indies, the purposes of this study were to: (1) delineate unique dimensions of customer service perceptions among guests and (2) report the finding of a study that measured guests' perceptions of the quality of customer service in all-inclusive resorts. The study asked the following research...

22 CFR 2.4 - Designation of official guests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Designation of official guests. 2.4 Section 2.4... Protocol. The designation of a person as an official guest is final. Pursuant to section 2658 of title 22... official guests is hereby delegated to the Chief of Protocol. (22 U.S.C. 2658) [45 FR 55716, Aug. 21, 1980] ...

Dissemination of go sun smart in outdoor recreation: effect of program exposure on sun protection of guests at high-altitude ski areas.

PubMed

Walkosz, Barbara J; Buller, David B; Andersen, Peter A; Scott, Michael D; Dignan, Mark B; Cutter, Gary R; Liu, Xia; Maloy, Julie A

2014-09-01

Go Sun Smart is a theory-based health communication program designed to influence sun-protection behaviors of employees and guests at high-altitude ski areas to reduce skin cancer risk. The effects of Go Sun Smart, in a Phase IV dissemination randomized posttest-only trial, on sun-protection behaviors of ski area guests are reported. Program use was assessed by on-site observation and guest message exposure, and sun protection was measured in intercept surveys at ski areas. Dissemination strategy-enhanced versus basic-was not significantly related to sun safety practices. Additional analyses examined the relation between message exposure and guests' sun safety practices. Ski areas displaying at least 6 Go Sun Smart materials in guest-only areas and 9 Go Sun Smart materials throughout the area increased guests' message exposure. Higher message exposure within the high-use ski areas was associated with improved sun protection by guests but not within the low-use ski areas. The authors underscore the importance of program implementation and message exposure on the success of evidence-based health communication efforts applied industrywide.

On the mechanism of action of gated molecular baskets: The synchronicity of the revolving motion of gates and in/out trafficking of guests

PubMed Central

Hermann, Keith; Rieth, Stephen; Taha, Hashem A; Wang, Bao-Yu; Hadad, Christopher M

2012-01-01

Summary We used dynamic 1H NMR spectroscopic methods to examine the kinetics and thermodynamics of CH3CCl3 (2) entering and leaving the gated molecular basket 1. We found that the encapsulation is first-order in basket 1 and guest 2, while the decomplexation is zeroth-order in the guest. Importantly, the interchange mechanism in which a molecule of CH3CCl3 directly displaces the entrapped CH3CCl3 was not observed. Furthermore, the examination of the additivity of free energies characterizing the encapsulation process led to us to deduce that the revolving motion of the gates and in/out trafficking of guests is synchronized, yet still a function of the affinity of the guest for occupying the basket: Specifically, the greater the affinity of the guest for occupying the basket, the less effective the gates are in “sweeping” the guest as the gates undergo their revolving motion. PMID:22423275

External and internal guest binding of a highly charged supramolecular host in water: deconvoluting the very different thermodynamics.

PubMed

Sgarlata, Carmelo; Mugridge, Jeffrey S; Pluth, Michael D; Tiedemann, Bryan E F; Zito, Valeria; Arena, Giuseppe; Raymond, Kenneth N

2010-01-27

NMR, UV-vis, and isothermal titration calorimetry (ITC) measurements probe different aspects of competing host-guest equilibria as simple alkylammonium guest molecules interact with both the exterior (ion-association) and interior (encapsulation) of the [Ga(4)L(6)](12-) supramolecular assembly in water. Data obtained by each independent technique measure different components of the host-guest equilibria and only when analyzed together does a complete picture of the solution thermodynamics emerge. Striking differences between the internal and external guest binding are found. External binding is enthalpy driven and mainly due to attractive interactions between the guests and the exterior surface of the assembly while encapsulation is entropy driven as a result of desolvation and release of solvent molecules from the host cavity.

Creating Learning Experiences that Promote Informal Science Education: Designing Conservation-Focused Interactive Zoo Exhibits through Action Research

NASA Astrophysics Data System (ADS)

Kalenda, Peter

Research on exhibit design over the past twenty years has started to identify many different methods to increase the learning that occurs in informal education environments. This study utilized relevant research on exhibit design to create and study the effectiveness of a mobile interactive exhibit at the Seneca Park Zoo that promotes socialization, engagement in science, and conservation-related practices among guests. This study will serve as one component of a major redesign project at the Seneca Park Zoo for their Rocky Coasts exhibit. This action research study targeted the following question, "How can interactive exhibits be designed to promote socialization, engagement in science, and real-world conservation-related practices (RCPs) among zoo guests?" Specific research questions included: 1. In what ways did guests engage with the exhibit? 2. In what ways were guests impacted by the exhibit? a) What evidence exists, if any, of guests learning science content from the exhibit? b) What evidence exists, if any, of guests being emotionally affected by the exhibit? c) What evidence exists, if any, of guests changing their RCPs after visiting the exhibit? Data were collected through zoo guest surveys completed by zoo guests comparing multiple exhibits, interviews with guests before and after they used the prototype exhibit, observations and audio recordings of guests using the prototype exhibit, and follow-up phone interviews with guests who volunteered to participate. Data were analyzed collaboratively with members of the zoo's exhibit Redesign Team using grounded theory qualitative data analysis techniques to find patterns and trends among data. Initial findings from data analysis were used to develop shifts in the exhibit in order to increase visitor engagement and learning. This process continued for two full action research spirals, which resulted in three iterations of the prototype exhibit. The overall findings of this study highlight the ways in which guests engaged with and were impacted by this exhibit. Findings revealed the importance of the location of interactives and signage as well as a range of readability concerns for visitor engagement. In addition, findings highlight the roles of parents in informal learning environments, and the impact of exhibit design on dwell time and questioning. This study demonstrates the value and importance of utilizing an iterative design process informed by action research when creating learning experiences in zoos. This study also reinforces how difficult it can be to both influence and measure the shifting of guests' RCPs.

Chemically armed mercenary ants protect fungus-farming societies.

PubMed

Adams, Rachelle M M; Liberti, Joanito; Illum, Anders A; Jones, Tappey H; Nash, David R; Boomsma, Jacobus J

2013-09-24

The ants are extraordinary in having evolved many lineages that exploit closely related ant societies as social parasites, but social parasitism by distantly related ants is rare. Here we document the interaction dynamics among a Sericomyrmex fungus-growing ant host, a permanently associated parasitic guest ant of the genus Megalomyrmex, and a raiding agro-predator of the genus Gnamptogenys. We show experimentally that the guest ants protect their host colonies against agro-predator raids using alkaloid venom that is much more potent than the biting defenses of the host ants. Relatively few guest ants are sufficient to kill raiders that invariably exterminate host nests without a cohabiting guest ant colony. We also show that the odor of guest ants discourages raider scouts from recruiting nestmates to host colonies. Our results imply that Sericomyrmex fungus-growers obtain a net benefit from their costly guest ants behaving as a functional soldier caste to meet lethal threats from agro-predator raiders. The fundamentally different life histories of the agro-predators and guest ants appear to facilitate their coexistence in a negative frequency-dependent manner. Because a guest ant colony is committed for life to a single host colony, the guests would harm their own interests by not defending the host that they continue to exploit. This conditional mutualism is analogous to chronic sickle cell anemia enhancing the resistance to malaria and to episodes in human history when mercenary city defenders offered either net benefits or imposed net costs, depending on the level of threat from invading armies.

Theory and practice of conventional adventitious virus testing.

PubMed

Gregersen, Jens-Peter

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) For decades conventional tests in cell cultures and in laboratory animals have served as standard methods for broad-spectrum screening for adventitious viruses. New virus detection methods based on molecular biology have broadened and improved our knowledge about potential contaminating viruses and about the suitability of the conventional test methods. This paper summarizes and discusses practical aspects of conventional test schemes, such as detectability of various viruses, questionable or false-positive results, animal numbers needed, time and cost of testing, and applicability for rapidly changing starting materials. Strategies to improve the virus safety of biological medicinal products are proposed. The strategies should be based upon a flexible application of existing and new methods along with a scientifically based risk assessment. However, testing alone does not guarantee the absence of adventitious agents and must be accompanied by virus removing or virus inactivating process steps for critical starting materials, raw materials, and for the drug product.

Stratigraphic and morphologic signatures of continental shelves, IGC 2016, Cape Town: an introduction

NASA Astrophysics Data System (ADS)

Green, A. N.; Cooper, J. A. G.

2018-02-01

This special issue of Geo-Marine Letters comprises seven contributions to the session "Stratigraphic and morphologic signatures of continental shelves" of the 35th International Geological Congress held in Cape Town (Republic of South Africa) on 27 August-4 September 2016. There is an additional article not presented at the conference but falling into the same general theme. The guest editors are A.N. Green and J.A.G. Cooper. The eight articles address several contemporary themes in continental shelf geology. They include the role of antecedent conditioning on the development of shelf stratigraphy and geomorphology; erosion of submerged shorelines and their preservation during (stepped) postglacial sea-level rise; the role of glacial processes (e.g. iceberg scouring during ice-sheet retreat); and the utility of archival data in addressing contemporary issues such as Holocene climate change and global oceanographic circulation systems. The continental shelf holds important information for understanding past and present global circulation and earth-ice-atmosphere interactions including sea-level change. It is hoped that these themes will spur further research that is slowly coming to the fore in several new and innovative mapping and exploration programmes emerging from an increasing number of coastal nations.

Hans Georg Trüper (1936–2016) and His Contributions to Halophile Research

PubMed Central

Oren, Aharon

2016-01-01

Prof. Hans Georg Trüper, one of the most important scientists in the field of halophile research, passed away on 9 March 2016 at the age of 79. I here present a brief obituary with special emphasis on Prof. Trüper’s contributions to our understanding of the halophilic prokaryotes and their adaptations to life in hypersaline environments. He has pioneered the study of the halophilic anoxygenic phototrophic sulfur bacteria of the Ectothiorhodospira—Halorhodospira group. Some of the species he and his group isolated from hypersaline and haloalkaline environments have become model organisms for the study of the mechanisms of haloadaptation: the functions of three major organic compounds – glycine betaine, ectoine, and trehalose – known to serve as “compatible solutes” in halophilic members of the Bacteria domain, were discovered during studies of these anoxygenic phototrophs. Prof. Trüper’s studies of hypersaline alkaline environments in Egypt also led to the isolation of the first known extremely halophilic archaeon (Natronomonas pharaonis). The guest editors dedicate this special volume of Life to the memory of Prof. Hans Georg Trüper. PMID:27187481

Open source libraries and frameworks for mass spectrometry based proteomics: A developer's perspective☆

PubMed Central

Perez-Riverol, Yasset; Wang, Rui; Hermjakob, Henning; Müller, Markus; Vesada, Vladimir; Vizcaíno, Juan Antonio

2014-01-01

Data processing, management and visualization are central and critical components of a state of the art high-throughput mass spectrometry (MS)-based proteomics experiment, and are often some of the most time-consuming steps, especially for labs without much bioinformatics support. The growing interest in the field of proteomics has triggered an increase in the development of new software libraries, including freely available and open-source software. From database search analysis to post-processing of the identification results, even though the objectives of these libraries and packages can vary significantly, they usually share a number of features. Common use cases include the handling of protein and peptide sequences, the parsing of results from various proteomics search engines output files, and the visualization of MS-related information (including mass spectra and chromatograms). In this review, we provide an overview of the existing software libraries, open-source frameworks and also, we give information on some of the freely available applications which make use of them. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. PMID:23467006

Open source libraries and frameworks for mass spectrometry based proteomics: a developer's perspective.

PubMed

Perez-Riverol, Yasset; Wang, Rui; Hermjakob, Henning; Müller, Markus; Vesada, Vladimir; Vizcaíno, Juan Antonio

2014-01-01

Data processing, management and visualization are central and critical components of a state of the art high-throughput mass spectrometry (MS)-based proteomics experiment, and are often some of the most time-consuming steps, especially for labs without much bioinformatics support. The growing interest in the field of proteomics has triggered an increase in the development of new software libraries, including freely available and open-source software. From database search analysis to post-processing of the identification results, even though the objectives of these libraries and packages can vary significantly, they usually share a number of features. Common use cases include the handling of protein and peptide sequences, the parsing of results from various proteomics search engines output files, and the visualization of MS-related information (including mass spectra and chromatograms). In this review, we provide an overview of the existing software libraries, open-source frameworks and also, we give information on some of the freely available applications which make use of them. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. Copyright © 2013 Elsevier B.V. All rights reserved.

Five years later: the current status of the use of proteomics and transcriptomics in EMF research.

PubMed

Leszczynski, Dariusz; de Pomerai, David; Koczan, Dirk; Stoll, Dieter; Franke, Helmut; Albar, Juan Pablo

2012-08-01

The World Health Organization's and Radiation and Nuclear Safety Authority's "Workshop on Application of Proteomics and Transcriptomics in Electromagnetic Fields Research" was held in Helsinki in the October/November 2005. As a consequence of this meeting, Proteomics journal published in 2006 a special issue "Application of Proteomics and Transcriptomics in EMF Research" (Vol. 6 No. 17; Guest Editor: D. Leszczynski). This Proteomics issue presented the status of research, of the effects of electromagnetic fields (EMF) using proteomics and transcriptomics methods, present in 2005. The current overview/opinion article presents the status of research in this area by reviewing all studies that were published by the end of 2010. The review work was a part of the European Cooperation in the Field of Scientific and Technical Research (COST) Action BM0704 that created a structure in which researchers in the field of EMF and health shared knowledge and information. The review was prepared by the members of the COST Action BM0704 task group on the high-throughput screening techniques and electromagnetic fields (TG-HTST-EMF). © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Message from the Editor

NASA Astrophysics Data System (ADS)

Stambaugh, Ronald D.

2014-01-01

This last year being an odd numbered year, the pages of Nuclear Fusion saw a large influx of expanded papers from the 2012 Fusion Energy Conference in San Diego. Many papers have focused on the scientific and technical challenges posed by ITER. Contributions are steadily increasing from the new superconducting tokamaks in Asia. The ITER Project continues to move ahead. Construction at the Cadarache site is quite remarkable. Buildings completed include the huge Poloidal Field Coils Winding Facility and the Headquarters building, which has been occupied by the ITER staff. Work is progressing on the Assembly building and the Cryostat Workshop. The base of the tokamak complex is being laid. Besides the construction that is taking place and will take place at the site, components from around the world have to navigate the complex route from Marseilles to the site. A test convoy replicating the dimensions and weights of the most exceptional ITER loads successfully traversed that route in 2013. We are pleased to report that the IAEA and ITER have finalized the agreement for ITER authors to publish papers in Nuclear Fusion . Nuclear Fusion is proud to continue its key role in providing the leading forum for the documentation of scientific progress and exchange of research results internationally toward fusion energy. Refereeing The Nuclear Fusion editorial office appreciates greatly the effort made by our referees to sustain the high quality of the journal. Since January 2005, we have been offering the most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in previous years. The following people have been selected: J.M. Canik, Oak Ridge National Laboratory, USA I.T. Chapman, Culham Centre for Fusion Energy, UK L.-G. Eriksson, Commission of the European Communities, Belgium T. Evans, General Atomics, USA A. Hassanein, Purdue University, USA Y.-M. Jeon, National Fusion Research Institute, Spain S. Kajita, Nagoya University, Japan T.P. Kiviniemi, Aalto University, Finland R.M. More, Lawrence Livermore National Laboratory, USA F. Sattin, Associazione Euratom-ENEA-CNR, Italy J.A. Snipes, ITER Organization, France W. Suttrop, Max Planck Institute for Plasma Physics-Garching, Germany F.L. Tabares, Energy Environment and Technology Research Centre, Spain Y. Ueda, Osaka University, Japan V.S. Voitsenya, Kharkov Institute of Physics and Technology, Ukraine G. Xu, Chinese Academy of Sciences-Hefei Institutes of Physical Sciences, People's Republic of China In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion . At the end of this issue we give the full list of all referees for 2013. Our thanks to them! We also wish to express our thanks to Paul Thomas, who served as Guest Editor for the special issue of the overview and summary reports from the 24th Fusion Energy Conference in San Diego, October 2012. This issue is of great value as a summary of the major developments worldwide in fusion research in the last two years. Authors The winner of the 2013 Nuclear Fusion Award is D.G. Whyte for the paper: I-mode: an H-mode energy confinement regime with L-mode particle transport in Alcator C-Mod [1], and we congratulate him and coauthors on this achievement. We also note special topic papers published in 2013: Technical challenges in the construction of the steady-state stellarator Wendestein 7-X by H.S. Bosch et al [2], Power requirements for electron cyclotron current drive and ion cyclotron resonance heating for sawtooth control in ITER by I.T. Chapman et al [3] and IFMIF: overview of the validation activities by J. Knaster et al [4]. The Board of Editors The Board of Editors has had a substantial turnover in members. For their great service to the journal, we wish to thank the following outgoing Board Members whose term of service was reached at the end of 2012: Keith Burrell, Atsushi Fukuyama, Guenter Janeschitz, Myeun Kwon, Alberto Loarte, Derek Stork, Tony Taylor and Kazuo Toi. We welcome the new Board Members who have joined the Board from the start of 2013: Pietro Barabaschi, Riccardo Betti, Rich Callis, Wonho Choi, Yasuaki Kishimoto, Joaquin Sánchez, Paul Thomas, Mickey Wade, Howard Wilson, Hiroshi Yamada and Steve Zinkle. We look forward to working with the Board to maintain the high standing of Nuclear Fusion . The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors, referees, and Board of Editors, so its success is also due to the tireless and largely unsung efforts of the IAEA Nuclear Fusion office in Vienna and IOP Publishing in Bristol. I would like to express my personal thanks to the team for the support that they have given to me, the authors and the referees. Season's greetings I would like to wish our readers, authors, referees, Board of Editors, and Vienna and Bristol office staff season's greetings and thank them for their contributions to Nuclear Fusion in 2013. References [1] Whyte D.G. et al 2010 I-mode: an H-mode energy confinement regime with L-mode particle transport in Alcator C-Mod Nucl. Fusion 50 105005 [2] Bosch H.-S. et al 2013 Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X Nucl. Fusion 53 126001 [3] Chapman I.T. et al 2013 Power requirements for electron cyclotron current drive and ion cyclotron resonance heating for sawtooth control in ITER Nucl. Fusion 53 066001 [4] Knaster J. et al 2013 IFMIF: overview of the validation activities Nucl. Fusion 53 116001

The molecular transport and intercalation of guest molecules into hydrogen-bonded metal-organic frameworks (HMOFs)

NASA Astrophysics Data System (ADS)

Hogan, Greg Anthony

The process of molecular transport and intercalation has been widely studied for many years, resulting in the discovery of molecular frameworks that are capable of hosting guest molecules or ions. Layered and porous metal-organic frameworks (MOFs) have been found to have applications in the field of catalysis, storage, separations, and ion-exchange. More recently, molecular components with peripheral hydrogen-bonding moieties have been used to affect the synthesis of hydrogen-bonded metal-organic frameworks (HMOFs) as an alternative to MOFs, which are interconnected via coordinate-covalent bonds. While MOFs are perhaps stronger materials, HMOFs have the advantage of being easily modifiable and more flexible. Because HMOFs have not been extensively studied for their ability to host molecules, and because their ability to withstand guest loss and guest exchange is essentially unknown, here we report the synthesis and molecular transport properties of both close-packed and porous HMOFs. Layered materials can mimic the behavior of naturally occurring clays, where guest molecules are absorbed and the layer will expand to accommodate the entering guest molecule. We have created a clay mimic composed of a metal pyridine-dicarboxylates and ammonium counterions (a layered HMOF), which is suitable for studying the ability of such materials to absorb guest molecules. We can control the distance of the interlayer region, as well as the chemical nature (hydrophobic or hydrophilic) by varying the organic amine. The metal complex contains axial water ligands that are replaceable, and such ligand exchange has precedence in coordination polymer (MOF) systems, and has been termed "coordinative intercalation". Using the synthesized layered material we examined the process of intercalation, having chosen a variety of guest molecules ranging from alkyl to aryl molecules, each of which have substituents varying in size, shape and electronics. The first set of guest molecules are non-coordinating and are theoretically capable of entering the layer and anchoring freely through the use of non-covalent interactions. The second set of guest molecules contain a pyridine moiety that can exchange with the coordinated water ligand through coordinative-intercalation. The products have been characterized by TGA, DSC, UV-Vis, and powder XRD. Further work was dedicated to examining porous materials, which were created using organic diamines, rather than simple primary amines, as starting materials. The resulting diammonium cations act as pillars, forming open channels. The predefined channel dimensions allow the insertion of specific sized guest molecules. The walls of the channel are close-packed, so that in theory guest molecules can travel in one direction through the solid. Using the synthesized pillared structure we investigated guest inclusion and selectivity through the process of co-crystallization. The stability of the pillared structure in the absence of guests is also reported, as well as the potential for the empty pillared structure to withstand guest re-insertion and removal.

Effects of Facilitation Context on Attitude toward Sustainable Seafood

NASA Astrophysics Data System (ADS)

Denton, Kristen E.

This study examined how adult guests to the California Science Center engage with a specific conservation education topic: sustainable seafood. Sustainable seafood is a common education message delivered in informal science institutions. This study also investigated whether engaging in an activity about sustainable seafood while simultaneously viewing live fish species would have a greater impact on guests than participating in the same activity while viewing a laboratory space. The data showed that guests who participated in a hands-on activity about sustainable seafood knew more about conservation-related topics and were more likely to adopt behaviors conducive to sustainable seafood consumption than guests who participated in a different hands-on activity. The data also showed that the settings in which guests participate in this Sustainable Seafood activity do not influence their knowledge or behavior. This indicates that this Sustainable Seafood activity is effective in educating adult guests, regardless of the setting.

A room with a viewpoint revisited: descriptive norms and hotel guests' towel reuse behavior.

PubMed

Bohner, Gerd; Schlüter, Lena E

2014-01-01

Field experiments on descriptive norms as a means to increase hotel guests' towel reuse [1] were replicated and extended. In two hotels in Germany (Study 1: N = 724; Study 2: N = 204), descriptive norm messages suggesting that 75% of guests had reused their towels, or a standard message appealing to environmental concerns, were placed in guests' bathrooms. Descriptive norm messages varied in terms of proximity of the reference group ("hotel guests" vs. "guests in this room") and temporal proximity (currently vs. two years previous). Reuse of towels was unobtrusively recorded. Results showed that reuse rates were high overall and that both standard and descriptive norm messages increased reuse rates compared to a no-message baseline. However, descriptive norm messages were not more effective than the standard message, and effects of proximity were inconsistent across studies. Discussion addresses cultural and conceptual issues in comparing the present findings with previous ones.

Cucurbit[8]uril-Containing Multilayer Films for the Photocontrolled Binding and Release of a Guest Molecule.

PubMed

Nicolas, Henning; Yuan, Bin; Zhang, Xi; Schönhoff, Monika

2016-03-15

The powerful host-guest chemistry of cucurbit[8]uril (CB[8]) was employed to obtain photoresponsive polyelectrolyte multilayer films for the reversible and photocontrolled binding and release of an organic guest molecule. For this purpose, we designed and synthesized a polyelectrolyte with azobenzene side groups. Then, CB[8] was associated with the azo side group to obtain a supramolecular host-guest complex that was further used as building block in order to prepare photoresponsive and CB[8]-containing polyelectrolyte multilayer films. Ultraviolet spectroscopy and a dissipative quartz crystal microbalance are employed to monitor the formation of the host-guest complex and the layer-by-layer self-assembly of the multilayer films, respectively. We demonstrate that the photoresponsive properties of the azo side groups are maintained before and after host-guest complexation with CB[8] in solution and within the multilayer films, respectively. A guest molecule was then specifically included as second binding partner into the CB[8]-containing multilayer films. Subsequently, the release of the guest was performed by UV light irradiation due to the trans-cis isomerization of the adjacent azo side groups. Re-isomerization of the azo side groups was achieved by VIS light irradiation and enabled the rebinding of the guest into CB[8]. Finally, we demonstrate that the photocontrolled binding and release within CB[8]-containing multilayer films can reliably and reversibly be performed over a period of more than 2 weeks with constant binding efficiency. Therefore, we expect such novel type of photosensitive films to have promising future applications in the field of stimuli-responsive nanomaterials.

ESI-MS of Cucurbituril Complexes Under Negative Polarity.

PubMed

Rodrigues, Maria A A; Mendes, Débora C; Ramamurthy, Vaidhyanathan; Da Silva, José P

2017-11-01

Electrospray ionization mass spectrometry (ESI-MS) is a powerful tool to study host-guest supramolecular interactions. ESI-MS can be used for detailed gas-phase reactivity studies, to clarify the structure, or simply to verify the formation of complexes. Depending on the structure of the host and of the guest, negative and/or positive ESI are used. Here we report the unexpected formation of host-guest complexes between cucurbit[n]urils (n = 7, 8, CB[n]) and amine, styryl pyridine, and styryl pyridine dimer cations, under negative ESI. Non-complexed CB[n] form double charged halide (Br - , Cl - , F - ) adducts. Under negative ESI, halide ions interact with CB[n] outer surface hydrogen atoms. One to one host-guest complexes (1:1) of CB[n] with positive charged guests were also observed as single and double charged ions under negative ESI. The positive charge of guests is neutralized by ion-pairing with halide anions. Depending on the number of positive charges guests retain in the gas phase, one or two additional halide ions are required for neutralization. Complexes 1:2 of CB[8] with styryl pyridines retain two halide ions in the gas phase, one per guest. Styryl pyridine dimers form 1:1 complexes possessing a single extra halide ion and therefore a single positive charge. Negative ESI is sensitive to small structural differences between complexes, distinguishing between 1:2 complexes of styryl pyridine-CB[8] and corresponding 1:1 complexes with the dimer. Negative ESI gives simpler spectra than positive ESI and allows the determination of guest charge state of CB[n] complexes in the gas phase. Graphical Abstract ᅟ.

Chemically armed mercenary ants protect fungus-farming societies

PubMed Central

Adams, Rachelle M. M.; Liberti, Joanito; Illum, Anders A.; Jones, Tappey H.; Nash, David R.; Boomsma, Jacobus J.

2013-01-01

The ants are extraordinary in having evolved many lineages that exploit closely related ant societies as social parasites, but social parasitism by distantly related ants is rare. Here we document the interaction dynamics among a Sericomyrmex fungus-growing ant host, a permanently associated parasitic guest ant of the genus Megalomyrmex, and a raiding agro-predator of the genus Gnamptogenys. We show experimentally that the guest ants protect their host colonies against agro-predator raids using alkaloid venom that is much more potent than the biting defenses of the host ants. Relatively few guest ants are sufficient to kill raiders that invariably exterminate host nests without a cohabiting guest ant colony. We also show that the odor of guest ants discourages raider scouts from recruiting nestmates to host colonies. Our results imply that Sericomyrmex fungus-growers obtain a net benefit from their costly guest ants behaving as a functional soldier caste to meet lethal threats from agro-predator raiders. The fundamentally different life histories of the agro-predators and guest ants appear to facilitate their coexistence in a negative frequency-dependent manner. Because a guest ant colony is committed for life to a single host colony, the guests would harm their own interests by not defending the host that they continue to exploit. This conditional mutualism is analogous to chronic sickle cell anemia enhancing the resistance to malaria and to episodes in human history when mercenary city defenders offered either net benefits or imposed net costs, depending on the level of threat from invading armies. PMID:24019482

PREFACE: International Conference on Advancement in Science and Technology 2012 (iCAST): Contemporary Mathematics, Mathematical Physics and their Applications

NASA Astrophysics Data System (ADS)

Ganikhodjaev, Nasir; Mukhamedov, Farrukh; Hee, Pah Chin

2013-04-01

The 4th International Conference on the Advancement of Science and Technology 2012 (iCAST 2012), with theme 'Contemporary Mathematics, Mathematical Physics and their Applications', took place in Kuantan, Malaysia, from Wednesday 7 to Friday 9 November 2012. The conference was attended by more than 100 participants, and hosted about 160 oral and poster papers by more than 140 pre-registered authors. The key topics of the 4th iCAST 2012 include Pure Mathematics, Applied Mathematics, Theoretical/Mathematical Physics, Dynamical Systems, Statistics and Financial Mathematics. The scientific program was rather full since after the Keynote and Invited Talks in the morning, four parallel sessions ran every day. However, according to all attendees, the program was excellent with a high level of talks and the scientific environment was fruitful; thus all attendees had a creative time. The conference aimed to promote the knowledge and development of high-quality research in mathematical fields concerned with the application of other scientific fields as well as modern technological trends in physics, chemistry, biology, medicine, economics, sociology and environmental sciences. We would like to thank the Keynote and the Invited Speakers for their significant contributions to 4th iCAST 2012. We would also like to thank the members of the International Scientific Committee and the members of the Organizing Committee. We cannot end without expressing our many thanks to International Islamic University Malaysia and our sponsors for their financial support . This volume presents selected papers which have been peer-reviewed. The editors hope that it may be useful and fruitful for scholars, researchers, and advanced technical members of the industrial laboratory facilities for developing new tools and products. Guest Editors Nasir Ganikhodjaev, Farrukh Mukhamedov and Pah Chin Hee The PDF contains the committee lists, board list and biographies of the plenary speakers.

Capturing Guest Dynamics in Metal-Organic Framework CPO-27-M (M = Mg, Zn) by (2)H Solid-State NMR Spectroscopy.

PubMed

Xu, Jun; Sinelnikov, Regina; Huang, Yining

2016-06-07

Metal-organic frameworks (MOFs) are promising porous materials for gas separation and storage as well as sensing. In particular, a series of isostructural MOFs with coordinately unsaturated metal centers, namely, CPO-27-M or M-MOF-74 (M = Mg, Zn, Mn, Fe, Ni, Co, Cu), have shown exceptional adsorption capacity and selectivity compared to those of classical MOFs that contain only fully coordinated metal sites. Although it is widely accepted that the interaction between guest molecules and exposed metal centers is responsible for good selectivity and large maximum uptake, the investigation of such guest-metal interaction is very challenging because adsorbed molecules are usually disordered in the pores and undergo rapid thermal motions. (2)H solid-state NMR (SSNMR) spectroscopy is one of the most extensively used techniques for capturing guest dynamics in porous materials. In this work, variable-temperature (2)H wide-line SSNMR experiments were performed on CPO-27-M (M = Mg, Zn) loaded with four prototypical guest molecules: D2O, CD3CN, acetone-d6, and C6D6. The results indicate that different guest molecules possess distinct dynamic behaviors inside the channel of CPO-27-M. For a given guest molecule, its dynamic behavior also depends on the nature of the metal centers. The binding strength of guest molecules is discussed on the basis of the (2)H SSNMR data.

Special issue on quantum physics with non-Hermitian operators Special issue on quantum physics with non-Hermitian operators

NASA Astrophysics Data System (ADS)

Bender, Carl M.; Fring, Andreas; Guenther, Uwe; Jones, Hugh F.

2012-01-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to quantum physics with non-Hermitian operators. The main motivation behind this special issue is to gather together recent results, developments and open problems in this rapidly evolving field of research in a single comprehensive volume. We expect that such a special issue will become a valuable reference for the broad scientific community working in mathematical and theoretical physics. The issue will be open to all contributions containing new results on non-Hermitian theories which are explicitly PT-symmetric and/or pseudo-Hermitian or quasi-Hermitian. The main novelties in the past years in this area have been many experimental observations, realizations, and applications of PT symmetric Hamiltonians in optics and microwave cavities. We especially invite contributions on the theoretical interpretations of these recent PT-symmetric experiments and on theoretical proposals for new experiments. Editorial policy The Guest Editors for this issue are Carl Bender, Andreas Fring, Uwe Guenther and Hugh Jones. The areas and topics for this issue include, but are not limited to: spectral problems novel properties of complex optical potentials PT-symmetry related threshold lasers and spectral singularities construction of metric operators scattering theory supersymmetric theories Lie algebraic and Krein-space methods random matrix models classical and semi-classical models exceptional points in model systems operator theoretic approaches microwave cavities aspects of integrability and exact solvability field theories with indefinite metric All contributions will be refereed and processed according to the usual procedure of the journal. Papers should report original and significant research that has not already been published. Guidelines for preparation of contributions The deadline for contributed papers will be 31 March 2012. This deadline will allow the special issue to appear before the end of November 2012. There is a nominal page limit of 15 printed pages per contribution (invited review papers can be longer). For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on publishing your work in Journal of Physics A: Mathematical and Theoretical may be found at iopscience.iop.org/jphysa. Contributions to the special issue should be submitted by web upload via authors.iop.org/, or by email to jphysa@iop.org, quoting 'JPhysA Special issue on quantum physics with non-Hermitian operators'. Submissions should ideally be in standard LaTeX form. Please see the website for further information on electronic submissions. All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. The special issue will be published in the print and online versions of the journal.

Special issue on quantum physics with non-Hermitian operators Special issue on quantum physics with non-Hermitian operators

NASA Astrophysics Data System (ADS)

Bender, Carl M.; Fring, Andreas; Guenther, Uwe; Jones, Hugh F.

2012-01-01

This is a call for contributions to a special issue of Journal of Physics A: Mathematical and Theoretical dedicated to quantum physics with non-Hermitian operators. The main motivation behind this special issue is to gather together recent results, developments and open problems in this rapidly evolving field of research in a single comprehensive volume. We expect that such a special issue will become a valuable reference for the broad scientific community working in mathematical and theoretical physics. The issue will be open to all contributions containing new results on non-Hermitian theories which are explicitly PT-symmetric and/or pseudo-Hermitian or quasi-Hermitian. The main novelties in the past years in this area have been many experimental observations, realizations, and applications of PT symmetric Hamiltonians in optics and microwave cavities. We especially invite contributions on the theoretical interpretations of these recent PT-symmetric experiments and on theoretical proposals for new experiments. Editorial policy The Guest Editors for this issue are Carl Bender, Andreas Fring, Uwe Guenther and Hugh Jones. The areas and topics for this issue include, but are not limited to: spectral problems novel properties of complex optical potentials PT-symmetry related threshold lasers and spectral singularities construction of metric operators scattering theory supersymmetric theories Lie algebraic and Krein-space methods random matrix models classical and semi-classical models exceptional points in model systems operator theoretic approaches microwave cavities aspects of integrability and exact solvability field theories with indefinite metric All contributions will be refereed and processed according to the usual procedure of the journal. Papers should report original and significant research that has not already been published. Guidelines for preparation of contributions The deadline for contributed papers will be 31 March 2012. This deadline will allow the special issue to appear before the end of November 2012. There is a nominal page limit of 15 printed pages per contribution (invited review papers can be longer). For papers exceeding this limit, the Guest Editors reserve the right to request a reduction in length. Further advice on publishing your work in Journal of Physics A: Mathematical and Theoretical may be found at iopscience.iop.org/jphysa. Contributions to the special issue should be submitted by web upload via authors.iop.org, or by email to jphysa@iop.org, quoting 'JPhysA Special issue on quantum physics with non-Hermitian operators'. Submissions should ideally be in standard LaTeX form. Please see the website for further information on electronic submissions. All contributions should be accompanied by a read-me file or covering letter giving the postal and e-mail addresses for correspondence. The Publishing Office should be notified of any subsequent change of address. The special issue will be published in the print and online versions of the journal.

First report on the Oak Ridge K-25 Site Biological Monitoring and Abatement Program for Mitchell Branch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.G.; Adams, S.M.; Kszos, L.A.

1993-08-01

A modified National Pollutant Discharge Elimination System permit was issued to the Oak Ridge Gaseous Diffusion Plant (now referred to as the Oak Ridge K-25 Site) on September 11, 1986. The Oak Ridge K-25 Site is a former uranium-enrichment production facility, which is currently managed by Martin Marietta Energy Systems, Inc. for the US Department of Energy. As required in Part III (L) of that permit, a plan for the biological monitoring of Mitchell Branch (K-1700 stream) was prepared and submitted for approval to the US Environmental Protection Agency and the Tennessee Department of Environment and Conservation [formerly the Tennesseemore » Department of Health and Environment (Loar et al. 1992b)]. The K-25 Site Biological Monitoring and Abatement Program (BMAP) described biomonitoring activities that would be conducted over the duration of the permit. Because it was anticipated that the composition of existing effluent streams entering Mitchell Branch would be altered shortly after the modified permit was issued, sampling of the benthic invertebrate and fish communities (Task 4 of BMAP) was initiated in August and September 1986 respectively.« less

America's First Carl Sagan: Ormsby MacKnight Mitchel, Pre-Civil War Astronomer and Lecturer on the Cosmos

NASA Astrophysics Data System (ADS)

Osterbrock, D. E.

2002-12-01

In the years before television, videos, radio. movies, or even loudspeakers, Ormsby MacKnight Mitchel (1809-1862) was the best-known popularizer of astronomy and the scientific study of the universe in nineteenth-century America. Each winter he traveled the country by railroad, steamer, and stagecoach, speaking to large paying crowds in principal cities from Boston, New York, and Philadelphia through Cincinnati to New Orleans on the cosmos and our place in it, with special attention to possible inhabitants of planers orbiting other stars. Mitchel had much the same attraction as Sagan did in our time, and awakened many people's interest in astronomy through the human angle, as Carl did. His argument was simple, and according to Frank Triplett goes back thousands of years: other stars are suns, our sun has planets with people on one of them, why should not other stars also have populated planets? But first Mitchel, like Sagan, always explained clearly the discoveries of astronomy that fleshed out this argument with facts. He emphasized the ``clockwork universe", governed by gravity, that Newton, Herschel, and Laplace had investigated and found to be stable. There were many other similarities between these two great popularizers. Mitchel's base was the Cincinnati Observatory, which he had founded, raising the funds for it himself in small contributions from hundreds of ``members", which he publicised as far more democratic than support from European kings and lords. He went abroad to get a telescope, and finally found his ``Great [12-inch] Refractor" in Munich, with help from John Quincy Adams, Astronomer Royal George Biddle Airy, and Paris Observatory Director Fracois Arago, in spite of a rebuff by President John Tyler. These episodes have similarities in Sagan's lobbying NASA for close-up images of Mars. Views of other American professional astronomers on life on other worlds will also be described briefly, from Denison Olmsted, Elias Loomis, Charles A. Young (who injected physics into the discussion), and Simon Newcomb (who had an early, two-factor form of the ``Drake equation", and who thought planets had been discovered in extra-solar systems), to W. W. Campbell and H. D. Curtis (who published a quantitative estimate of the minimum-mass planet that could be detected with their radial-velocity spectrograph).

Polarization response of clathrate hydrates capsulated with guest molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Qun; Li, Jinshan, E-mail: ljs915@263.net, E-mail: myang@scu.edu.cn; Huang, Hui

2016-05-28

Clathrate hydrates are characterized by their water cages encapsulating various guest atoms or molecules. The polarization effect of these guest-cage complexes was studied with combined density functional theory and finite-field calculations. An addition rule was noted for these systems whose total polarizability is approximately equal to the polarizability sum of the guest and the cage. However, their distributional polarizability computed with Hirshfeld partitioning scheme indicates that the guest–cage interaction has considerable influence on their polarization response. The polarization of encapsulated guest is reduced while the polarization of water cage is enhanced. The counteraction of these two opposite effects leads tomore » the almost unchanged total polarizability. Further analysis reveals that the reduced polarizability of encapsulated guest results from the shielding effect of water cage against the external field and the enhanced polarizability of water cage from the enhanced bonding of hydrogen bonds among water molecules. Although the charge transfer through the hydrogen bonds is rather small in the water cage, the polarization response of clathrate hydrates is sensitive to the changes of hydrogen bonding strength. The guest encapsulation strengthens the hydrogen bonding network and leads to enhanced polarizability.« less

New Horizons Pluto Flyby Guest Operations

NASA Astrophysics Data System (ADS)

Simon, M.; Turney, D.; Fisher, S.; Carr, S. S.

2015-12-01

On July 14, 2015, after 9.5 years of cruise, NASA's New Horizons spacecraft flew past the Pluto system to gather first images humankind had ever seen on Pluto and its five moons. While much has been discovered about the Pluto system since New Horizons launch in 2006, the system has never been imaged at high resolution and anticipation of the "First Light" of the Pluto system had been anticipated by planetary enthusiasts for decades. The Johns Hopkins Applied Physics Laboratory (APL), which built and operates New Horizons, was the focal point for gathering three distinct groups: science and engineering team members; media and public affairs representatives; and invited public, including VIP's. Guest operations activities were focused on providing information primarily to the invited public and VIP's. High level objectives for the Guest Operations team was set to entertain and inform the general public, offer media reaction shots, and to deconflict activities for the guests from media activities wherever possible. Over 2000 people arrived at APL in the days surrounding closest approach for guest, science or media operations tracks. Reaction and coverage of the Guest Operations events was universally positive and global in impact: iconic pictures of the auditorium waving flags during the moment of closest approach were published in media outlets on every continent. Media relations activities ensured coverage in all key media publications targeted for release, such as the New York Times, Science, Le Monde, and Nature. Social and traditional media coverage of the events spanned the globe. Guest operations activities are designed to ensure that a guest has a memorable experience and leaves with a lifelong memory of the mission and their partnership in the activity. Results, lessons learned, and other data from the New Horizons guest operations activity will be presented and analyzed.

Mechanism of host-guest complexation by cucurbituril.

PubMed

Márquez, César; Hudgins, Robert R; Nau, Werner M

2004-05-12

The factors affecting host-guest complexation between the molecular container compound cucurbit[6]uril (CB6) and various guests in aqueous solution are studied, and a detailed complexation mechanism in the presence of cations is derived. The formation of the supramolecular complex is studied in detail for cyclohexylmethylammonium ion as guest. The kinetics and thermodynamics of complexation is monitored by NMR as a function of temperature, salt concentration, and cation size. The binding constants and the ingression rate constants decrease with increasing salt concentration and cation-binding constant, in agreement with a competitive binding of the ammonium site of the guest and the metal cation with the ureido carbonyl portals of CB6. Studies as a function of guest size indicate that the effective container volume of the CB6 cavity is approximately 105 A(3). It is suggested that larger guests are excluded for two reasons: a high activation barrier for ingression imposed by the tight CB6 portals and a destabilization of the complex due to steric repulsion inside. For example, in the case of the nearly spherical azoalkane homologues 2,3-diazabicyclo[2.2.1]hept-2-ene (DBH, volume ca. 96 A(3)) and 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO, volume ca. 110 A(3)), the former forms the CB6 complex promptly with a sizable binding constant (1300 M(-1)), while the latter does not form a complex even after several months at optimized complexation conditions. Molecular mechanics calculations are performed for several CB6/guest complexes. A qualitative agreement is found between experimental and calculated activation energies for ingression as a function of both guest size and state of protonation. The potential role of constrictive binding by CB6 is discussed.

Relationship between the cohesion of guest particles on the flow behaviour of interactive mixtures.

PubMed

Mangal, Sharad; Gengenbach, Thomas; Millington-Smith, Doug; Armstrong, Brian; Morton, David A V; Larson, Ian

2016-05-01

In this study, we aimed to investigate the effects cohesion of small surface-engineered guest binder particles on the flow behaviour of interactive mixtures. Polyvinylpyrrolidone (PVP) - a model pharmaceutical binder - was spray-dried with varying l-leucine feed concentrations to create small surface-engineered binder particles with varying cohesion. These spray-dried formulations were characterised by their particle size distribution, morphology and cohesion. Interactive mixtures were produced by blending these spray-dried formulations with paracetamol. The resultant blends were visualised under scanning electron microscope to confirm formation of interactive mixtures. Surface coverage of paracetamol by guest particles as well as the flow behaviour of these mixtures were examined. The flow performance of interactive mixtures was evaluated using measurements of conditioned bulk density, basic flowability energy, aeration energy and compressibility. With higher feed l-leucine concentrations, the surface roughness of small binder particles increased, while their cohesion decreased. Visual inspection of the SEM images of the blends indicated that the guest particles adhered to the surface of paracetamol resulting in effective formation of interactive mixtures. These images also showed that the low-cohesion guest particles were better de-agglomerated that consequently formed a more homogeneous interactive mixture with paracetamol compared with high-cohesion formulations. The flow performance of interactive mixtures changed as a function of the cohesion of the guest particles. Interactive mixtures with low-cohesion guest binder particles showed notably improved bulk flow performance compared with those containing high-cohesion guest binder particles. Thus, our study suggests that the cohesion of guest particles dictates the flow performance of interactive mixtures. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

Guest molecules as a design element for metal–organic frameworks

DOE PAGES

Allendorf, Mark D.; Medishetty, Raghavender; Fischer, Roland A.

2016-11-07

The well-known synthetic versatility of MOFs is rooted in the ability to predict the metal ion coordination geometry and the vast possibilities to use organic chemistry to modify the linker groups. However, the use of “non-innocent” guest molecules as a component of framework design has been largely ignored. Nevertheless, recent reports show that the presence of guest molecules can have dramatic effects, even when these are seemingly innocuous species such as water or polar solvents. Advantages of using guests to impart new properties to MOFs include the relative ease of introducing new functionalities, the ability to modify the properties materialmore » at will by removing the guest or inserting different ones, and avoidance of the difficulties associated with synthesizing new frameworks, which can be challenging even when the basic topology remains constant. In this article we describe the “Guest@MOF” concept and provide examples illustrating its potential as a new MOF design element.« less

Untangling the Diverse Interior and Multiple Exterior Guest Interactions of a Supramolecular Host by the Simultaneous Analysis of Complementary Observables.

PubMed

Sgarlata, Carmelo; Raymond, Kenneth N

2016-07-05

The entropic and enthalpic driving forces for encapsulation versus sequential exterior guest binding to the [Ga4L6](12-) supramolecular host in solution are very different, which significantly complicates the determination of these thermodynamic parameters. The simultaneous use of complementary techniques, such as NMR, UV-vis, and isothermal titration calorimetry, enables the disentanglement of such multiple host-guest interactions. Indeed, data collected by each technique measure different components of the host-guest equilibria and together provide a complete picture of the solution thermodynamics. Unfortunately, commercially available programs do not allow for global analysis of different physical observables. We thus resorted to a novel procedure for the simultaneous refinement of multiple parameters (ΔG°, ΔH°, and ΔS°) by treating different observables through a weighted nonlinear least-squares analysis of a constrained model. The refinement procedure is discussed for the multiple binding of the Et4N(+) guest, but it is broadly applicable to the deconvolution of other intricate host-guest equilibria.

Host–guest complexes between cryptophane-C and chloromethanes revisited

PubMed Central

Takacs, Z; Soltesova, M; Kowalewski, J; Lang, J; Brotin, T; Dutasta, J-P

2013-01-01

Cryptophane-C is composed of two nonequivalent cyclotribenzylene caps, one of which contains methoxy group substituents on the phenyl rings. The two caps are connected by three OCH2CH2O linkers in an anti arrangement. Host–guest complexes of cryptophane-C with dichloromethane and chloroform in solution were investigated in detail by nuclear magnetic resonance techniques and density functional theory (DFT) calculations. Variable temperature proton and carbon-13 spectra show a variety of dynamic processes, such as guest exchange and host conformational transitions. The guest exchange was studied quantitatively by exchange spectroscopy measurements or by line-shape analysis. The conformational preferences of the guest-containing host were interpreted through cross-relaxation measurements, providing evidence of the gauche+2 and gauche−2 conformations of the linkers. In addition, the mobility of the chloroform guest inside the cavity was studied by carbon-13 relaxation experiments. Combining different types of evidence led to a detailed picture of molecular recognition, interpreted in terms of conformational selection. Copyright © 2012 John Wiley & Sons, Ltd. PMID:23132654

Spectroscopic investigation of different concentrations of the vapour deposited copper phthalocyanine as a "guest" in polyimide matrix.

PubMed

Georgiev, Anton; Yordanov, Dancho; Dimov, Dean; Assa, Jacob; Spassova, Erinche; Danev, Gencho

2015-04-05

Nanocomposite layers 250 nm copper phthalocyanine/polyimide prepared by simultaneous vapour deposition of three different sources were studied. Different concentrations of copper phthalocyanine as a "guest" in polyimide matrix as a function of conditions of the preparation have been determined by FTIR (Fourier Transform Infrared) and UV-VIS (Ultraviolet-Visible) spectroscopies. The aim was to estimate the possibility of the spectroscopic methods for quantitative determination of the "guest" and compare with the quality of the polyimide thin films in relation to the "guest" concentration. The band at 1334 cm(-1) has been used for quantitative estimation of "guest" in polyimide matrix. The concentrations of the copper phthalocyanine less than 20% require curve fitting techniques with Fourier self deconvolution. The relationship between "guest" concentrations and degree of imidization, as well as the electronic UV-VIS spectra are discussed in relation to the composition, imidization degree and the two crystallographic modification of the embedded chromophore. Copyright © 2015 Elsevier B.V. All rights reserved.

Guest Speakers in School-Based Sexuality Education

ERIC Educational Resources Information Center

McRee, Annie-Laurie; Madsen, Nikki; Eisenberg, Marla E.

2014-01-01

This study, using data from a statewide survey (n = 332), examined teachers' practices regarding the inclusion of guest speakers to cover sexuality content. More than half of teachers (58%) included guest speakers. In multivariate analyses, teachers who taught high school, had professional preparation in health education, or who received…

Review of Journal of Cardiovascular Magnetic Resonance (JCMR) 2015-2016 and transition of the JCMR office to Boston.

PubMed

Manning, Warren J

2017-12-28

The Journal of Cardiovascular Magnetic Resonance (JCMR) is the official publication of the Society for Cardiovascular Magnetic Resonance (SCMR). In 2016, the JCMR published 93 manuscripts, including 80 research papers, 6 reviews, 5 technical notes, 1 protocol, and 1 case report. The number of manuscripts published was similar to 2015 though with a 12% increase in manuscript submissions to an all-time high of 369. This reflects a decrease in the overall acceptance rate to <25% (excluding solicited reviews). The quality of submissions to JCMR continues to be high. The 2016 JCMR Impact Factor (which is published in June 2016 by Thomson Reuters) was steady at 5.601 (vs. 5.71 for 2015; as published in June 2016), which is the second highest impact factor ever recorded for JCMR. The 2016 impact factor means that the JCMR papers that were published in 2014 and 2015 were on-average cited 5.71 times in 2016.In accordance with Open-Access publishing of Biomed Central, the JCMR articles are published on-line in the order that they are accepted with no collating of the articles into sections or special thematic issues. For this reason, over the years, the Editors have felt that it is useful to annually summarize the publications into broad areas of interest or themes, so that readers can view areas of interest in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes with previously published JCMR papers to guide continuity of thought in the journal. In addition, I have elected to open this publication with information for the readership regarding the transition of the JCMR editorial office to the Beth Israel Deaconess Medical Center, Boston and the editorial process.Though there is an author publication charge (APC) associated with open-access to cover the publisher's expenses, this format provides a much wider distribution/availability of the author's work and greater manuscript citation. For SCMR members, there is a substantial discount in the APC. I hope that you will continue to send your high quality manuscripts to JCMR for consideration. Importantly, I also ask that you consider referencing recent JCMR publications in your submissions to the JCMR and elsewhere as these contribute to our impact factor. I also thank our dedicated Associate Editors, Guest Editors, and reviewers for their many efforts to ensure that the review process occurs in a timely and responsible manner and that the JCMR continues to be recognized as the leading publication in our field.

Energy transfer in a mechanically trapped exciplex.

PubMed

Klosterman, Jeremy K; Iwamura, Munetaka; Tahara, Tahei; Fujita, Makoto

2009-07-15

Host-guest complexes involving M(6)L(4) coordination cages can display unusual photoreactivity, and enclathration of the very large fluorophore bisanthracene resulted in an emissive, mechanically trapped intramolecular exciplex. Mechanically linked intramolecular exciplexes are important for understanding the dependence of energy transfer on donor-acceptor distance, orientation, and electronic coupling but are relatively unexplored. Steady-state and picosecond time-resolved fluorescence measurements have revealed that selective excitation of the encapsulated guest fluorophore results in efficient energy transfer from the excited guest to an emissive host-guest exciplex state.

The guest-worker in Western Europe--an obituary.

PubMed

Castles, S

1986-01-01

The significance of guest workers is examined for six Western European countries. It is found that "the dynamics of the migratory process led to family reunification and settlement, against the original intentions of the workers, employers and states concerned. The recruitment of guest-workers stopped after 1974, but many migrants stayed on, becoming permanent ethnic minorities, in a situation of economic and social crisis. It is argued that guest-worker systems inevitably lead to permanent migration in the long run, and that it is better to plan for orderly settlement through appropriate policies." excerpt

Host-guest complexes of local anesthetics with cucurbit[6]uril and para-sulphonatocalix[8]arene in the solid state

NASA Astrophysics Data System (ADS)

Danylyuk, Oksana; Butkiewicz, Helena; Coleman, Anthony W.; Suwinska, Kinga

2017-12-01

Here we describe the host-guest inclusion complexes of local anesthetic drugs with two macrocyclic hosts cucurbit[6]uril and para-sulphonatocalix[8]arene in the solid state. The anesthetic agents used in the co-crystallization with the supramolecular hosts are lidocaine, procaine, procainamide, prilocaine and proparacaine. Both macrocycles encapsulate the alkylammonium moieties of anestetics guests into their cavities although the mechanism of complexation, host-guest stoichiometry and geometry differ depending on the nature of the supramolecular host.

Binding of carboxylate and trimethylammonium salts to octa-acid and TEMOA deep-cavity cavitands

NASA Astrophysics Data System (ADS)

Sullivan, Matthew R.; Sokkalingam, Punidha; Nguyen, Thong; Donahue, James P.; Gibb, Bruce C.

2017-01-01

In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests ( 3- 8) to two hosts ( 1 and 2) were measured by 1H NMR and ITC. Each host possessed a unique and well-defined binding pocket, whilst the wide array of amphiphilic guests possessed binding moieties that included: a terminal alkyne, nitro-arene, alkyl halide and cyano-arene groups. Solubilizing head groups for the guests included both positively charged trimethylammonium and negatively charged carboxylate functionality. Measured association constants ( K a ) covered five orders of magnitude, ranging from 56 M-1 for guest 6 binding with host 2 up to 7.43 × 106 M-1 for guest 6 binding to host 1.

Complexation of triptycene-derived macrotricyclic polyether with paraquat derivatives, diquat, and a 2,7-diazapyrenium salt: guest-induced conformational changes of the host.

PubMed

Han, Ying; Cao, Jing; Li, Peng-Fei; Zong, Qian-Shou; Zhao, Jian-Min; Guo, Jia-Bin; Xiang, Jun-Feng; Chen, Chuan-Feng

2013-04-05

Complexation between a triptycene-derived macrotricyclic polyether containing two dibenzo-[30]-crown-10 cavities and different functionalized paraquat derivatives, diquat, and a 2,7-diazapyrenium salt in both solution and solid state was investigated in detail. It was found that depending on the guests with different terminal functional groups and structures, the macrotricyclic polyether could form 1:1 or 1:2 complexes with the guests in different complexation modes in solution and also in the solid state. Especially, the conformation of the macrotricyclic polyether was efficiently adjusted by the encapsulated guests, which was to some extent similar to substrate-induced fit of enzymes. Moreover, the binding and releasing of the guests in the complexes could be controlled by potassium ions.

NMR Investigation of Chloromethane Complexes of Cryptophane-A and Its Analogue with Butoxy Groups

PubMed Central

2014-01-01

Host–guest complexes between cryptophane-A as host and dichloromethane and chloroform as guests are investigated using 1H and 13C NMR spectroscopy. Moreover, a related cryptophane, with the methoxy groups replaced by butoxy units (cryptophane-But), and its complexes with the same guests were also studied. Variable temperature spectra showed effects of chemical exchange between the free and bound guests, as well as of conformational exchange of the host. The guest exchange was studied quantitatively by exchange spectroscopy or line shape analysis. Extraction of kinetic and thermodynamic parameters led to the characterization of the affinity between guests and hosts. On the other hand, the host exchange was investigated by means of 13C Carr–Purcell–Meiboom–Gill (CPMG) relaxation dispersion which aims at the determination of the transverse relaxation rate R2, the inverse of the transverse relaxation time T2, as a function of the repetition of the π pulses in a CPMG train. The variation of the measured transverse relaxation rate with the repetition rate νCPMG indicated conformational exchange occurring on the microsecond–millisecond time scale. Structural information was obtained through measurements of cross-relaxation rates, both within the host and between the host and the guest protons. The NMR results were supported by DFT calculations. PMID:24472055

IBEX Sky Map Press Conference

NASA Image and Video Library

2009-10-14

Don Mitchell, far left, Cassini spacecraft instrument scientist, IBEX co-Investigator, Johns Hopkins University Applied Physics Laboratory in Laurel, Md., answers questions on findings made by NASA's Interstellar Boundary Explorer, IBEX, at NASA Headquarters in Washington, Thursday, Oct. 10, 2009. Mitchell is joined by IBEX mission colleagues David McComas, far right, IBEX spacecraft principal investigator and senior executive director, Space Science and Engineering Division, Southwest Research Institute in San Antonio; Eric Christian, IBEX deputy mission scientist, NASA's Goddard Space Flight Center in Greenbelt, Md.; Rosine Lallement, senior scientist at the French National Center for Scientific Research in Paris; Lindsay Bartolone, second from left, lead of Education and Public Outreach at the Adler Planetarium in Chicago. Photo Credit: (NASA/Carla Cioffi)

Further clarifying proximal withdrawal states and the turnover criterion space: Comment on Hom, Mitchell, Lee, and Griffeth (2012).

PubMed

Maertz, Carl P

2012-09-01

In "Reviewing Employee Turnover: Focusing on Proximal Withdrawal States and an Expanded Criterion," Hom, Mitchell, Lee, and Griffeth (2012) brought together many of the most important content and process factors in the employee turnover literature. In this paper, I attempt to clarify the true contributions of this framework for the turnover area and at the same time explain why improved prediction is not among these contributions. I then enumerate 3 theoretically problematic aspects of the proposed framework, which limit its contribution. Finally, I suggest 3 directions that researchers should pursue in order to test and extend the framework. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

Prediction of clathrate structure type and guest position by molecular mechanics.

PubMed

Fleischer, Everly B; Janda, Kenneth C

2013-05-16

The clathrate hydrates occur in various types in which the number, size, and shape of the various cages differ. Usually the clathrate type of a specific guest is predicted by the size and shape of the molecular guest. We have developed a methodology to determine the clathrate type employing molecular mechanics with the MMFF force field employing a strategy to calculate the energy of formation of the clathrate from the sum of the guest/cage energies. The clathrate type with the most negative (most stable) energy of formation would be the type predicted (we mainly focused on type I, type II, or bromine type). This strategy allows for a calculation to predict the clathrate type for any cage guest in a few minutes on a laptop computer. It proved successful in predicting the clathrate structure for 46 out of 47 guest molecules. The molecular mechanics calculations also provide a prediction of the guest position within the cage and clathrate structure. These predictions are generally consistent with the X-ray and neutron diffraction studies. By supplementing the diffraction study with molecular mechanics, we gain a more detailed insight regarding the details of the structure. We have also compared MM calculations to studies of the multiple occupancy of the cages. Finally, we present a density functional calculation that demonstrates that the inside of the clathrates cages have a relatively uniform and low electrostatic potential in comparison with the outside oxygen and hydrogen atoms. This implies that van der Waals forces will usually be dominant in the guest-cage interactions.

Guest Chain ``Melting'' in Incommensurate Host-Guest Potassium

NASA Astrophysics Data System (ADS)

McBride, Emma; Munro, Keith; McMahon, Malcolm

2013-06-01

Upon increasing pressure the group-I elements transform from close-packed structures (bcc and fcc) to a series of low-symmetry complex structures. Residing in the middle of the group, potassium (K) has numerous structures in common with its neighbours, and, in fact, is remarkably structurally similar to sodium (Na) and rubidium (Rb). For example, the post-fcc transition in K is to a composite incommensurate host-guest structure (tI19), and the host structure of this phase is isostructural with that found in Na and Rb. Previously we have reported that below 16.7GPa, the Bragg peaks from the guest component of tI19-Rb broaden considerably, signalling a loss of the inter-chain correlation, or a ``melting'' of the chains. Furthermore, in tI19-Na above 125 GPa, the Bragg peaks from the guest component are also broadened, suggesting that the guest chains are also nearly ``melted.'' During studies of the melting curve of K, we observed that the guest peaks from tI19-K broaden dramatically on heating. Here we report single-crystal, quasi-single-crystal, and powder synchrotron x-ray diffraction measurements of tI19-K to 50 GPa and 800 K, which allowed a detailed study of this chain ``melting'' transition. The order-disorder transition is clearly visible over a 30 GPa pressure range, and there are significant changes in the gradient of the phase boundary, which may be influenced by the nature of the guest structure. Furthermore, data extending the melting curve will also be presented.

Diffusion of a Highly-Charged Supramolecular Assembly: Direct Observation of Ion-Association in Water

DOE Office of Scientific and Technical Information (OSTI.GOV)

University of California, Berkeley; Lawrence Berkeley National Laboratory; Raymond, Kenneth

2007-10-22

Understanding the solution behavior of supramolecular assemblies is essential for a full understanding of the formation and chemistry of synthetic host-guest systems. While the interaction between host and guest molecules is generally the focus of mechanistic studies of host-guest complexes, the interaction of the host-guest complex with other species in solution remains largely unknown, although in principle accessible by diffusion studies. Several NMR techniques are available to monitor diffusion and have recently been reviewed. Pulsed gradient spin-echo (PGSE) NMR methods have attracted increasing interest, since they allow diffusion coefficients to be measured with high accuracy; they have been successfully usedmore » with observation of {sup 7}Li and {sup 31}P nuclei as well as with {sup 1}H NMR. We report here the direct measurement of diffusion coefficients to observe ion-association interactions by counter cations with a highly-charged supramolecular assembly. Raymond and coworkers have described the design and chemistry of a class of metal-ligand supramolecular assemblies over the past decade. The [Ga{sub 4}L{sub 6}]{sup 12-} (L = 1,5-bis(2,3-dihydroxybenzamido)naphthalene) (1) (Figure 1) assembly has garnered the most attention, with the exploration of the dynamics and mechanism of guest exchange as well as the ability of 1 to achieve either stoichiometric or catalytic reactions inside its interior cavity. Recent studies have revealed the importance of counter cations in solution on the chemistry of 1. During the mechanistic study of the C-H bond activation of aldehydes by [Cp*Ir(PMe{sub 3})(olefin){sup +} {contained_in} 1]{sup 11-} a stepwise guest dissociation mechanism with an ion-paired intermediate was proposed. Similarly, in the mechanism for the hydrolysis of iminium cations generated from the 3-aza Cope rearrangement of enammonium cations in 1, the presence of an exterior ion association was part of the kinetic model. To further substantiate the indirect kinetic evidence for such ion-paired species, we sought to explore the solution behavior of 1 by studying the diffusion of 1 with varying alkali and tetraalkyl ammonium cations. For large molecules in solution, such as synthetic supramolecular assemblies, the diffusion behavior of host and guest molecules can provide valuable information on host-guest interaction. One characteristic feature of a stable host-guest complex is that the host and guest molecules diffuse at the same rate in solution; this has been observed in a number of supramolecular systems. In order to confirm that this system was suitable for study by diffusion NMR spectroscopy, a PGSE-DOSY spectrum was acquired of [NEt{sub 4} {contained_in} 1]{sup 11-} (Figure 2), which shows that the host and guest molecules diffuse at the same rate. Quantitative analysis of the data, from monitoring the integral of host and guest resonances as a function of applied gradient strength, gave identical diffusion coefficients, confirming that the host and guest molecules diffuse together.« less

Can we beat the biotin-avidin pair?: cucurbit[7]uril-based ultrahigh affinity host-guest complexes and their applications.

PubMed

Shetty, Dinesh; Khedkar, Jayshree K; Park, Kyeng Min; Kim, Kimoon

2015-12-07

The design of synthetic, monovalent host-guest molecular recognition pairs is still challenging and of particular interest to inquire into the limits of the affinity that can be achieved with designed systems. In this regard, cucurbit[7]uril (CB[7]), an important member of the host family cucurbit[n]uril (CB[n], n = 5-8, 10, 14), has attracted much attention because of its ability to form ultra-stable complexes with multiple guests. The strong hydrophobic effect between the host cavity and guests, ion-dipole and dipole-dipole interactions of guests with CB portals helps in cooperative and multiple noncovalent interactions that are essential for realizing such strong complexations. These highly selective, strong yet dynamic interactions can be exploited in many applications including affinity chromatography, biomolecule immobilization, protein isolation, biological catalysis, and sensor technologies. In this review, we summarize the progress in the development of high affinity guests for CB[7], factors affecting the stability of complexes, theoretical insights, and the utility of these high affinity pairs in different challenging applications.

Complexation of imidazopyridine-based cations with a 24-crown-8 ether host: [2]pseudorotaxane and partially threaded structures.

PubMed

Moreno-Olivares, Surisadai I; Cervantes, Ruy; Tiburcio, Jorge

2013-11-01

A new series of linear molecules derived from 1,2-bis(imidazopyridin-2-yl)ethane can fully or partially penetrate the cavity of the dibenzo-24-crown-8 macrocycle to produce a new family of host-guest complexes. Protonation or alkylation of the nitrogen atoms on the pyridine rings led to an increase in the guest total positive charge up to 4+ and simultaneously generated two new recognition sites (pyridinium motifs) that are in competition with the 1,2-bis(benzimidazole)ethane motif for the crown ether. The relative position of the pyridine ring and the chemical nature of the N-substituent determined the preferred motif and the host-guest complex geometry: (i) for linear guests with relatively bulky groups (i.e., a benzyl substituent), the 1,2-bis(benzimidazole)ethane motif is favored, leading to a fully threaded complex with a [2]pseudorotaxane geometry; (ii) for small substituents, such as -H and -CH3 groups, regardless of the guest shape, the pyridinium motifs are preferred, leading to external partially threaded complexes in a 2:1 host to guest stoichiometry.

Effect of pore occupancy on the acoustic properties of zeolitic imidazolate framework (ZIF)-8: A Brillouin spectroscopic study at ambient and low temperatures

NASA Astrophysics Data System (ADS)

Radhakrishnan, Dhanya; Narayana, Chandrabhas

2015-12-01

Brillouin spectroscopy is used to study the effect of pore occupancy on the elastic constants by incorporating various guest molecules into zeolitic imidazolate framework (ZIF)-8. A systematic study on the effect of mass and polarizability of the guest has been carried out by incorporating alcohols of varying chain lengths at room temperature. The interaction between the guest and host affects the elastic properties, lifetimes and guest dynamics inside the pores. The elastic anisotropy was seen to reduce upon incorporation of the guests. We have also studied the temperature dependence of the acoustic modes on gas adsorption to understand the framework flexibility. The Brillouin shift of the acoustic modes increases upon temperature dependent gas adsorption with transverse acoustic modes exhibiting a larger shift. This suggests a hardening of otherwise low shear modulus of ZIF-8. Our findings give insight into the role of guest molecules and temperature in tuning the elastic properties of ZIF-8 which is important for practical applications.

Amphiphilic inclusion spaces for various guests and regulation of fluorescence intensity of 1,8-bis(4-aminophenyl)anthracene crystals.

PubMed

Sugino, Misa; Hatanaka, Keisuke; Araki, Yusuke; Hisaki, Ichiro; Miyata, Mikiji; Tohnai, Norimitsu

2014-03-10

A host framework for inclusion of various guest molecules was investigated by preparation of inclusion crystals of 1,8-bis(4-aminophenyl)anthracene (1,8-BAPA) with organic solvents. X-ray crystallographic analysis revealed construction of the same inclusion space incorporating 1,8-BAPA and eight guest molecules including both non-polar (benzene) and polar guests (N,N-dimethylformamide, DMF). Fluorescence efficiencies varied depending on guest molecule polarity; DMF inclusion crystals exhibited the highest fluorescence intensity (ΦF=0.40), four times as high as that of a benzene inclusion crystal (ΦF=0.10). According to systematic investigations of inclusion phenomena, strong host–guest interactions and filling of the inclusion space led to a high fluorescence intensity. Temperature-dependent fluorescence spectral measurements revealed these factors effectively immobilised the host framework. Although hydrogen bonding commonly decreases fluorescence intensity, the present study demonstrated that such strong interactions provide excellent conditions for fluorescence enhancement. Thus, this remarkable behaviour has potential application toward sensing of highly polar molecules, such as biogenic compounds.

Molecular recognition of curcumin (Indian Ayurvedic medicine) by the supramolecular probe, p-t-butyl calix(8)arene

NASA Astrophysics Data System (ADS)

Meenakshi, C.; Jayabal, P.; Ramakrishnan, V.

2014-06-01

The thermodynamic property of the host-guest complexes formed between the curcumin, component of Indian Ayurvedic medicine turmeric, a drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene has been used as a host molecule and curcumin as a guest molecule. Optical absorption spectral studies were carried out to investigate the molecular recognition properties of p-t-butyl calix(8)arene with curcumin. The stochiometry of the host-guest complexes formed and the binding constant were determined. An interesting 1:1 and 4:1 stochiometric host-guest complexes were formed. Job's continuous method of variation and Benesi-Hildebrand expression were used for the determination of binding constant and the stochiometry of the host-guest complex formed.

Second report on the Oak Ridge K-25 Site Biological Monitoring and Abatement Program for Mitchell Branch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.G.; Adams, S.M.; Hinzman, R.L.

1994-03-01

On September 11, 1986, a modified National Pollutant Discharge Elimination System permit was issued for the Oak Ridge Gaseous Diffusion Plant (ORGDP; now referred to as the Oak Ridge K-25 Site), a former uranium-enrichment production facility. As required in Part III of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed for the biological monitoring of Mitchell Branch (K-1700 stream) and submitted for approval to the US EPA and the Tennessee Department of Environment and Conservation. The plan described biomonitoring activities that would be conducted over the duration of the permit. The objectives of the BMAP are tomore » demonstrate that the effluent limitations established for the Oak Ridge K-25 Site protect and maintain the use of Mitchell Branch for growth and propagation of fish and other aquatic life, and to document the effects on stream biota resulting from operation of major new pollution abatement facilities. The BMAP consists of four tasks: ambient toxicity testing; bioaccumulation studies; biological indicator studies; and ecological surveys of stream communities, including benthic macroinvertebrates and fish. This document is the second in a series of reports presenting the results of the studies that were conducted over various periods of time between August 1987 and June 1990.« less

Electrical conductivity behavior of Gum Arabic biopolymer-Fe3O4 nanocomposites

NASA Astrophysics Data System (ADS)

Bhakat, D.; Barik, P.; Bhattacharjee, A.

2018-01-01

Present work reports a study on the electrical conduction properties of some composites of Gum Arabic biopolymer and magnetite nanoparticles as host and guest, respectively, synthesized in different weight percentages. The nanocomposites are found to be non-extrinsic type of semiconductors with guest content dependent trap distribution of charge carriers. Conductivity of these materials increases with increasing guest content along with a concomitant decrease in the activation energy. Percolation theory has been employed for the analysis of the electrical conductivity results to explore the effect of the guest on the electrical conductivity of the host.

AGU Publications Volunteers Feted At Elegant Editors' Evening

NASA Astrophysics Data System (ADS)

Panning, Jeanette

2013-01-01

The 2012 Fall Meeting Editors' Evening, held at the City Club of San Francisco, was hosted by the Publications Committee and is the premier social event for editors and associate editors attending the Fall Meeting. The evening commenced with a welcome from Carol Finn, incoming AGU president, in which she expressed her thanks to the editors and associate editors for volunteering their time to benefit AGU.

A Student-Centered Guest Lecturing: A Constructivism Approach to Promote Student Engagement

ERIC Educational Resources Information Center

Li, Lei; Guo, Rong

2015-01-01

Student engagement has become a big challenge in higher education, especially when distance learning is getting more and more popular. Guest lecturing is a popular method to bring relevance to the classroom and engage in students. Ground on the theory of constructivism, this paper introduces a student-centered guest lecturing that allows students…

Be My Guest: A Survey of Mass Communication Students' Perception of Guest Speakers

ERIC Educational Resources Information Center

Merle, Patrick F.; Craig, Clay

2017-01-01

The use of guest speakers as a pedagogical technique across disciplines at the college level is hardly novel. However, empirical assessment of journalism and mass communication students' perceptions of this practice has not previously been conducted. To fill this gap, this article presents results from an online survey specifically administered to…

Dynamic free energy surfaces for sodium diffusion in type II silicon clathrates.

PubMed

Slingsby, J G; Rorrer, N A; Krishna, L; Toberer, E S; Koh, C A; Maupin, C M

2016-02-21

Earth abundant semiconducting type II Si clathrates have attracted attention as photovoltaic materials due to their wide band gaps. To realize the semiconducting properties of these materials, guest species that arise during the synthesis process must be completely evacuated from the host cage structure post synthesis. A common guest species utilized in the synthesis of Si clathrates is Na (metal), which templates the clathrate cage formation. Previous experimental investigations have identified that it is possible to evacuate Na from type II clathrates to an occupancy of less than 1 Na per unit cell. This work investigates the energetics, kinetics, and resulting mechanism of Na diffusion through type II Si clathrates by means of biased molecular dynamics and kinetic Monte Carlo simulations. Well-tempered metadynamics has been used to determine the potential of mean force for Na moving between clathrate cages, from which the thermodynamic preferences and transition barrier heights have been obtained. Kinetic Monte Carlo simulations based on the metadynamics results have identified the mechanism of Na diffusion in type II Si clathrates. The overall mechanism consists of a coupled diffusive process linked via electrostatic guest-guest interactions. The large occupied hexakaidechedral cages initially empty their Na guests to adjacent empty large cages, thereby changing the local electrostatic environment around the occupied small pentagonal dodecahedral cages and increasing the probability of Na guests to leave the small cages. This coupled process continues through the cross-over point that is identified as the point where large and small cages are equally occupied by Na guests. Further Na removal results in the majority of guests residing in the large cages as opposed to the small cages, in agreement with experiments, and ultimately a Na free structure.

Perspectives of host faculty and trainees on international visiting faculty to paediatric academic departments in East Africa

PubMed Central

Russ, Christiana M; Ganapathi, Lakshmi; Marangu, Diana; Silverman, Melanie; Kija, Edward; Bakeera-Kitaka, Sabrina; Laving, Ahmed

2016-01-01

Background Investments in faculty exchanges to build physician workforce capacity are increasing. Little attention has been paid to the expectations of host institution faculty and trainees. This prospective qualitative research study explored faculty and resident perspectives about guest faculty in paediatric departments in East Africa, asking (1) What are the benefits and challenges of hosting guest faculty, (2) What factors influence the effectiveness of faculty visits and (3) How do host institutions prepare for faculty visits? Methods We recruited 36 faculty members and residents from among four paediatric departments in East Africa to participate in semistructured interviews which were audio recorded and transcribed. Data were qualitatively analysed using principles of open coding and thematic analysis. We achieved saturation of themes. Results Benefits of faculty visits varied based on the size and needs of host institutions. Emergent themes included the importance of guest faculty time commitment, and mutual preparation to ensure that visit goals and scheduling met host needs. We documented conflicts that developed around guest emotional responses and ethical approaches to clinical resource limitations, which some hosts tried to prepare for and mitigate. Imbalance in resources led to power differentials; some hosts sought partnerships to re-establish control over the process of having guests. Conclusions We identified that guest faculty can assist paediatric institutions in building capacity; however, effective visits require: (1) mutually agreed on goals with appropriate scheduling, visit length and commitment to ensure that the visits meet the host's needs, (2) careful selection and preparation of guest faculty to meet the host's goals, (3) emotional preparation by prospective guests along with host orientation to clinical work in the host's setting and (4) attention to funding sources for the visit and mitigation of resulting power differentials. PMID:28588960

Photocaged Competitor Guests: A General Approach Toward Light-Activated Cargo Release From Cucurbiturils.

PubMed

Romero, Miguel A; Basílio, Nuno; Moro, Artur J; Domingues, Mara; González-Delgado, José A; Arteaga, Jesús F; Pischel, Uwe

2017-09-21

A general approach toward the light-induced guest release from cucurbit[7]uril by means of a photoactivatable competitor was devised. An o-nitrobenzyl-caged competitor is photolyzed to generate a competitive guest that can displace cargo from the host macrocycle solely based on considerations of chemical equilibrium. With this method the release of terpene guests from inclusion complexes with cucurbit[7]uril was demonstrated. The binding of the herein investigated terpenes, all being lead fragrant components in essential oils, has been characterized for the first time. They feature binding constants of up to 10 8  L mol -1 and a high differential binding selectivity (spanning four orders of magnitude for the binding constants for the particular set of terpenes). By fine-tuning the photoactivatable competitor guest, selective and also sequential release of the terpenes was achieved. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Structural transitions and guest/host complexing of liquid crystal helical nanofilaments induced by nanoconfinement.

PubMed

Kim, Hanim; Ryu, Seong Ho; Tuchband, Michael; Shin, Tae Joo; Korblova, Eva; Walba, David M; Clark, Noel A; Yoon, Dong Ki

2017-02-01

A lamellar liquid crystal (LC) phase of certain bent-core mesogenic molecules can be grown in a manner that generates a single chiral helical nanofilament in each of the cylindrical nanopores of an anodic aluminum oxide (AAO) membrane. By introducing guest molecules into the resulting composite chiral nanochannels, we explore the structures and functionality of the ordered guest/host LC complex, verifying the smectic-like positional order of the fluidic nematic LC phase, which is obtained by the combination of the LC organization and the nanoporous AAO superstructure. The guest nematic LC 4'- n -pentyl-4-cyanobiphenyl is found to form a distinctive fluid layered ordered LC complex at the nanofilament/guest interface with the host 1,3-phenylene bis[4-(4-nonyloxyphenyliminomethyl)benzoate], where this interface contacts the AAO cylinder wall. Filament growth form is strongly influenced by mixture parameters and pore dimensions.

Supramolecular guests in solvent driven block copolymer assembly: From internally structured nanoparticles to micelles

PubMed Central

Klinger, Daniel; Robb, Maxwell J.; Spruell, Jason M.; Lynd, Nathaniel A.; Hawker, Craig J.

2014-01-01

Supramolecular interactions between different hydrogen-bonding guests and poly(2-vinyl pyridine)-block-poly (styrene) can be exploited to prepare remarkably diverse self-assembled nanostructures in dispersion from a single block copolymer (BCP). The characteristics of the BCP can be efficiently controlled by tailoring the properties of a guest which preferentially binds to the P2VP block. For example, the incorporation of a hydrophobic guest creates a hydrophobic BCP complex that forms phase separated nanoparticles upon self-assembly. Conversely, the incorporation of a hydrophilic guest results in an amphiphilic BCP complex that forms spherical micelles in water. The ability to tune the self-assembly behavior and access dramatically different nanostructures from a single BCP substrate demonstrates the exceptional versatility of the self-assembly of BCPs driven by supramolecular interactions. This approach represents a new methodology that will enable the further design of complex, responsive self-assembled nanostructures. PMID:25525473

Structural transitions and guest/host complexing of liquid crystal helical nanofilaments induced by nanoconfinement

PubMed Central

Kim, Hanim; Ryu, Seong Ho; Tuchband, Michael; Shin, Tae Joo; Korblova, Eva; Walba, David M.; Clark, Noel A.; Yoon, Dong Ki

2017-01-01

A lamellar liquid crystal (LC) phase of certain bent-core mesogenic molecules can be grown in a manner that generates a single chiral helical nanofilament in each of the cylindrical nanopores of an anodic aluminum oxide (AAO) membrane. By introducing guest molecules into the resulting composite chiral nanochannels, we explore the structures and functionality of the ordered guest/host LC complex, verifying the smectic-like positional order of the fluidic nematic LC phase, which is obtained by the combination of the LC organization and the nanoporous AAO superstructure. The guest nematic LC 4′-n-pentyl-4-cyanobiphenyl is found to form a distinctive fluid layered ordered LC complex at the nanofilament/guest interface with the host 1,3-phenylene bis[4-(4-nonyloxyphenyliminomethyl)benzoate], where this interface contacts the AAO cylinder wall. Filament growth form is strongly influenced by mixture parameters and pore dimensions. PMID:28246642

New generation non-stationary portable neutron generators for biophysical applications of Neutron Activation Analysis.

PubMed

Marchese, N; Cannuli, A; Caccamo, M T; Pace, C

2017-01-01

Neutron sources are increasingly employed in a wide range of research fields. For some specific purposes an alternative to existing large-scale neutron scattering facilities, can be offered by the new generation of portable neutron devices. This review reports an overview for such recently available neutron generators mainly addressed to biophysics applications with specific reference to portable non-stationary neutron generators applied in Neutron Activation Analysis (NAA). The review reports a description of a typical portable neutron generator set-up addressed to biophysics applications. New generation portable neutron devices, for some specific applications, can constitute an alternative to existing large-scale neutron scattering facilities. Deuterium-Deuterium pulsed neutron sources able to generate 2.5MeV neutrons, with a neutron yield of 1.0×10 6 n/s, a pulse rate of 250Hz to 20kHz and a duty factor varying from 5% to 100%, when combined with solid-state photon detectors, show that this kind of compact devices allow rapid and user-friendly elemental analysis. "This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo". Copyright © 2016 Elsevier B.V. All rights reserved.

MS-READ: Quantitative measurement of amino acid incorporation.

PubMed

Mohler, Kyle; Aerni, Hans-Rudolf; Gassaway, Brandon; Ling, Jiqiang; Ibba, Michael; Rinehart, Jesse

2017-11-01

Ribosomal protein synthesis results in the genetically programmed incorporation of amino acids into a growing polypeptide chain. Faithful amino acid incorporation that accurately reflects the genetic code is critical to the structure and function of proteins as well as overall proteome integrity. Errors in protein synthesis are generally detrimental to cellular processes yet emerging evidence suggest that proteome diversity generated through mistranslation may be beneficial under certain conditions. Cumulative translational error rates have been determined at the organismal level, however codon specific error rates and the spectrum of misincorporation errors from system to system remain largely unexplored. In particular, until recently technical challenges have limited the ability to detect and quantify comparatively rare amino acid misincorporation events, which occur orders of magnitude less frequently than canonical amino acid incorporation events. We now describe a technique for the quantitative analysis of amino acid incorporation that provides the sensitivity necessary to detect mistranslation events during translation of a single codon at frequencies as low as 1 in 10,000 for all 20 proteinogenic amino acids, as well as non-proteinogenic and modified amino acids. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

Preface to the special issue on "Integrated Microwave Photonic Signal Processing"

NASA Astrophysics Data System (ADS)

Azaña, José; Yao, Jianping

2016-08-01

As Guest Editors, we are pleased to introduce this special issue on ;Integrated Microwave Photonic Signal Processing; published by the Elsevier journal Optics Communications. Microwave photonics is a field of growing importance from both scientific and practical application perspectives. The field of microwave photonics is devoted to the study, development and application of optics-based techniques and technologies aimed to the generation, processing, control, characterization and/or distribution of microwave signals, including signals well into the millimeter-wave frequency range. The use of photonic technologies for these microwave applications translates into a number of key advantages, such as the possibility of dealing with high-frequency, wide bandwidth signals with minimal losses and reduced electromagnetic interferences, and the potential for enhanced reconfigurability. The central purpose of this special issue is to provide an overview of the state of the art of generation, processing and characterization technologies for high-frequency microwave signals. It is now widely accepted that the practical success of microwave photonics at a large scale will essentially depend on the realization of high-performance microwave-photonic signal-processing engines in compact and integrated formats, preferably on a chip. Thus, the focus of the issue is on techniques implemented using integrated photonic technologies, with the goal of providing an update of the most recent advances toward realization of this vision.

A review of electron-phonon coupling seen in the high-Tc superconductors by angle-resolved photoemission studies (ARPES)

NASA Astrophysics Data System (ADS)

Cuk, T.; Lu, D. H.; Zhou, X. J.; Shen, Z.-X.; Devereaux, T. P.; Nagaosa, N.

2005-01-01

This issue of pss (b) - basic solid state physics contains a collection of Review Articles on the rather controversially discussed topic of Electron-Phonon Interaction in High-Temperature Superconductors, guest-edited by Miodrag Kuli, Johann Wolfgang Goethe-Universität Frankfurt/Main, Germany, with a Preface written by V. L. Ginzburg and E. G. Maksimov [1].The cover picture, taken from the review [2] by T. Cuk et al., shows plots of the electron-phonon coupling vertex, g2(k, k), where k, k are the initial and final electron momentum for electrons scattered by the bond-buckling phonon B1g (the out-of-phase vibration of the in-plane oxygen) in a tight-binding model of the copper-oxygen plane. The momentum dependence of this vertex, along with the d-wave superconducting gap and the van Hove singularity at the anti-node, accounts for the momentum dependence of the collective mode coupling seen in angle-resolved photoemission data on Bi2212.The present issue also sees the start of our rapid research letters, the fastest peer-reviewed publication medium in solid state physics. For more information see www.pss-rapid.com and the Editorial by the Editor-in-Chief Martin Stutzmann on page 7 [3].

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches.

PubMed

Lee, Jonathan A; Berg, Ellen L

2013-12-01

Innovation and new molecular entity production by the pharmaceutical industry has been below expectations. Surprisingly, more first-in-class small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) between 1999 and 2008 were identified by functional phenotypic lead generation strategies reminiscent of pre-genomics pharmacology than contemporary molecular targeted strategies that encompass the vast majority of lead generation efforts. This observation, in conjunction with the difficulty in validating molecular targets for drug discovery, has diminished the impact of the "genomics revolution" and has led to a growing grassroots movement and now broader trend in pharma to reconsider the use of modern physiology-based or phenotypic drug discovery (PDD) strategies. This "From the Guest Editors" column provides an introduction and overview of the two-part special issues of Journal of Biomolecular Screening on PDD. Terminology and the business case for use of PDD are defined. Key issues such as assay performance, chemical optimization, target identification, and challenges to the organization and implementation of PDD are discussed. Possible solutions for these challenges and a new neoclassic vision for PDD that combines phenotypic and functional approaches with technology innovations resulting from the genomics-driven era of target-based drug discovery (TDD) are also described. Finally, an overview of the manuscripts in this special edition is provided.

Ongoing ethical issues concerning authorship in biomedical journals: an integrative review.

PubMed

Kornhaber, Rachel Anne; McLean, Loyola M; Baber, Rodney J

2015-01-01

Health professionals publishing within the field of health sciences continue to experience issues concerning appropriate authorship, which have clinical, ethical, and academic implications. This integrative review sought to explore the key issues concerning authorship from a bioethical standpoint, aiming to explore the key features of the authorship debate. Studies were identified through an electronic search, using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus databases of peer-reviewed research, published between 2009 and 2014, limited to English language research, with search terms developed to reflect the current issues of authorship. From among the 279 papers identified, 20 research papers met the inclusion criteria. Findings were compiled and then arranged to identify themes and relationships. The review incorporated a wide range of authorship issues encompassing equal-credited authors, honorary (guest/gift) and ghost authorship, perception/experiences of authorship, and guidelines/policies. This review suggests that the International Committee of Medical Journal Editors' (ICMJE) recommended guidelines for authorship are not reflected in current authorship practices within the domain of health sciences in both low-and high-impact-factor journals. This devaluing of the true importance of authorship has the potential to affect the validity of authorship, diminish the real contributions of the true authors, and negatively affect patient care.

Melt Extrusion of High-Dose Co-Amorphous Drug-Drug Combinations : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

PubMed

Arnfast, Lærke; Kamruzzaman, Md; Löbmann, Korbinian; Aho, Johanna; Baldursdottir, Stefania; Rades, Thomas; Rantanen, Jukka

2017-12-01

Many future drug products will be based on innovative manufacturing solutions, which will increase the need for a thorough understanding of the interplay between drug material properties and processability. In this study, hot melt extrusion of a drug-drug mixture with minimal amount of polymeric excipient was investigated. Using indomethacin-cimetidine as a model drug-drug system, processability of physical mixtures with and without 5% (w/w) of polyethylene oxide (PEO) were studied using Differential Scanning Calorimetry (DSC) and Small Amplitude Oscillatory Shear (SAOS) rheometry. Extrudates containing a co-amorphous glass solution were produced and the solid-state composition of these was studied with DSC. Rheological analysis indicated that the studied systems display viscosities higher than expected for small molecule melts and addition of PEO decreased the viscosity of the melt. Extrudates of indomethacin-cimetidine alone displayed amorphous-amorphous phase separation after 4 weeks of storage, whereas no phase separation was observed during the 16 week storage of the indomethacin-cimetidine extrudates containing 5% (w/w) PEO. Melt extrusion of co-amorphous extrudates with low amounts of polymer was found to be a feasible manufacturing technique. Addition of 5% (w/w) polymer reduced melt viscosity and prevented phase separation.

2017 in-training initiative of the Journal of Assisted Reproduction and Genetics: the JARG Young Investigator Forum.

PubMed

Goldman, Kara N; Patrizio, Pasquale; Albertini, David

2017-01-01

The Journal of Assisted Reproduction and Genetics introduces the JARG Young Investigator Forum, an in-training initiative aimed to expand opportunities for young investigators. The JARG Young Investigator Forum has three primary goals: first, to increase opportunities for trainees and young investigators to contribute as researchers and writers. Trainees will be invited to publish mini-reviews based on their area of research interest/expertise and will have the opportunity to indicate "in-training" when submitting manuscripts as first author Educational research pertaining to reproductive medicine training will be added to the purview of the journal. Second, the Young Investigator Forum will increase opportunities for trainees to serve as journal reviewers and will provide mentorship throughout the peer review process. Third, trainees will have the unique opportunity to gain editorial experience by serving as a "guest editor" of the Young Investigator Forum, overseeing all editorial aspects of their assigned particular issue. Through authorship, peer review, and editorial experience, we seek to nurture the academic skills that are critical to a well-rounded career. The JARG Young Investigator Forum aims to foster career development for a generation of trainees who represent the future of reproductive medicine, and here, we outline the primary goals and objectives of the initiative.

A network-based method for the identification of putative genes related to infertility.

PubMed

Wang, ShaoPeng; Huang, GuoHua; Hu, Qinghua; Zou, Quan

2016-11-01

Infertility has become one of the major health problems worldwide, with its incidence having risen markedly in recent decades. There is an urgent need to investigate the pathological mechanisms behind infertility and to design effective treatments. However, this is made difficult by the fact that various biological factors have been identified to be related to infertility, including genetic factors. A network-based method was established to identify new genes potentially related to infertility. A network constructed using human protein-protein interactions based on previously validated infertility-related genes enabled the identification of some novel candidate genes. These genes were then filtered by a permutation test and their functional and structural associations with infertility-related genes. Our method identified 23 novel genes, which have strong functional and structural associations with previously validated infertility-related genes. Substantial evidence indicates that the identified genes are strongly related to dysfunction of the four main biological processes of fertility: reproductive development and physiology, gametogenesis, meiosis and recombination, and hormone regulation. The newly discovered genes may provide new directions for investigating infertility. This article is part of a Special Issue entitled "System Genetics" Guest Editor: Dr. Yudong Cai and Dr. Tao Huang. Copyright © 2016 Elsevier B.V. All rights reserved.

Tuning Proton Conductivity by Interstitial Guest Change in Size-Adjustable Nanopores of a CuI -MOF: A Potential Platform for Versatile Proton Carriers.

PubMed

Khatua, Sajal; Kumar Bar, Arun; Konar, Sanjit

2016-11-02

By exploiting the breathing behavior of nanopores, we have studied for the first time the dependency of the guest-induced proton conductivity of an interpenetrated Cu I metal-organic framework (Cu I -MOF, [1]) on various guest molecules. Proton conductivities of over 10 -3  S cm -1 under humid conditions were induced by a series of guest molecules, namely N,N-dimethylformamide, dimethyl sulfoxide, diethylamine, 1,4-dinitrobenzene, nitrobenzene, pyridine, and 1H-1,2,4-triazole. A detailed investigation of the guest-incorporated complexes revealed that low-energy proton conduction occurs under humid conditions through the Grotthuss mechanism in [1⊃NB] and through the vehicle mechanism in the rest of the complexes. Single-point energy computations revealed considerable stabilization upon guest encapsulation. To the best of our knowledge, [1] represents the first example in which considerably high protonic conductivity is triggered upon the facile incorporation of small molecules of such a variety. The investigation portrayed herein may be a stepping stone towards the rational design of proton-conducting materials for practical applications. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bottom-up Formation of Carbon-Based Structures with Multilevel Hierarchy from MOF-Guest Polyhedra.

PubMed

Wang, Tiesheng; Kim, Hyun-Kyung; Liu, Yingjun; Li, Weiwei; Griffiths, James T; Wu, Yue; Laha, Sourav; Fong, Kara D; Podjaski, Filip; Yun, Chao; Kumar, R Vasant; Lotsch, Bettina V; Cheetham, Anthony K; Smoukov, Stoyan K

2018-05-16

Three-dimensional carbon-based structures have proven useful for tailoring material properties in structural mechanical and energy storage applications. One approach to obtain them has been by carbonization of selected metal-organic frameworks (MOFs) with catalytic metals, but this is not applicable to most common MOF structures. Here, we present a strategy to transform common MOFs, by guest inclusions and high-temperature MOF-guest interactions, into complex carbon-based, diatom-like, hierarchical structures (named for the morphological similarities with the naturally existing diatomaceous species). As an example, we introduce metal salt guests into HKUST-1-type MOFs to generate a family of carbon-based nano-diatoms with two to four levels of structural hierarchy. We report control of the morphology by simple changes in the chemistry of the MOF and guest, with implications for the formation mechanisms. We demonstrate that one of these structures has unique advantages as a fast-charging lithium-ion battery anode. The tunability of composition should enable further studies of reaction mechanisms and result in the growth of a myriad of unprecedented carbon-based structures from the enormous variety of currently available MOF-guest candidates.

Calculating binding free energies of host-guest systems using the AMOEBA polarizable force field.

PubMed

Bell, David R; Qi, Rui; Jing, Zhifeng; Xiang, Jin Yu; Mejias, Christopher; Schnieders, Michael J; Ponder, Jay W; Ren, Pengyu

2016-11-09

Molecular recognition is of paramount interest in many applications. Here we investigate a series of host-guest systems previously used in the SAMPL4 blind challenge by using molecular simulations and the AMOEBA polarizable force field. The free energy results computed by Bennett's acceptance ratio (BAR) method using the AMOEBA polarizable force field ranked favorably among the entries submitted to the SAMPL4 host-guest competition [Muddana, et al., J. Comput.-Aided Mol. Des., 2014, 28, 305-317]. In this work we conduct an in-depth analysis of the AMOEBA force field host-guest binding thermodynamics by using both BAR and the orthogonal space random walk (OSRW) methods. The binding entropy-enthalpy contributions are analyzed for each host-guest system. For systems of inordinate binding entropy-enthalpy values, we further examine the hydrogen bonding patterns and configurational entropy contribution. The binding mechanism of this series of host-guest systems varies from ligand to ligand, driven by enthalpy and/or entropy changes. Convergence of BAR and OSRW binding free energy methods is discussed. Ultimately, this work illustrates the value of molecular modelling and advanced force fields for the exploration and interpretation of binding thermodynamics.

Special feature on imaging systems and techniques

NASA Astrophysics Data System (ADS)

Yang, Wuqiang; Giakos, George

2013-07-01

The IEEE International Conference on Imaging Systems and Techniques (IST'2012) was held in Manchester, UK, on 16-17 July 2012. The participants came from 26 countries or regions: Austria, Brazil, Canada, China, Denmark, France, Germany, Greece, India, Iran, Iraq, Italy, Japan, Korea, Latvia, Malaysia, Norway, Poland, Portugal, Sweden, Switzerland, Taiwan, Tunisia, UAE, UK and USA. The technical program of the conference consisted of a series of scientific and technical sessions, exploring physical principles, engineering and applications of new imaging systems and techniques, as reflected by the diversity of the submitted papers. Following a rigorous review process, a total of 123 papers were accepted, and they were organized into 30 oral presentation sessions and a poster session. In addition, six invited keynotes were arranged. The conference not only provided the participants with a unique opportunity to exchange ideas and disseminate research outcomes but also paved a way to establish global collaboration. Following the IST'2012, a total of 55 papers, which were technically extended substantially from their versions in the conference proceeding, were submitted as regular papers to this special feature of Measurement Science and Technology . Following a rigorous reviewing process, 25 papers have been finally accepted for publication in this special feature and they are organized into three categories: (1) industrial tomography, (2) imaging systems and techniques and (3) image processing. These papers not only present the latest developments in the field of imaging systems and techniques but also offer potential solutions to existing problems. We hope that this special feature provides a good reference for researchers who are active in the field and will serve as a catalyst to trigger further research. It has been our great pleasure to be the guest editors of this special feature. We would like to thank the authors for their contributions, without which it would not be possible to have this special feature published. We are grateful to all reviewers, who devoted their time and effort, on a voluntary basis, to ensure that all submissions were reviewed rigorously and fairly. The publishing staff of Measurement Science and Technology are particularly acknowledged for giving us timely advice on guest-editing this special feature.

Hotel smoking policies and their implementation: a survey of California hotel managers.

PubMed

Zakarian, Joy M; Quintana, Penelope J E; Winston, Carl H; Matt, Georg E

2017-01-01

Most states in the U.S. permit hotels to allow smoking in some guest rooms, and only five (Indiana, Michigan, North Dakota, Vermont, and Wisconsin) require that all hotel and motel rooms be 100% smoke-free (State and local 100% smokefree hotel and motel guest room laws enacted as of July 3, 2017). Little is known, however, about how hotels' smoking policies have been implemented. This study examined hotels' smoking policies and their implementation. A telephone survey of a random sample of 383 California hotel managers was conducted. Overall, 60.6% of hotels reported that smoking was prohibited in all guest rooms, and 4.7% reported that smoking was prohibited everywhere on their property. While California law permitted smoking in up to 65% of guest rooms, only 6.9% of rooms were reported as smoking-permitted. Over 90% of hotels had smoking rooms scattered among nonsmoking rooms, and about half of the smoking hotels reported that guests requesting either smoking or nonsmoking rooms were sometimes assigned to the other room type. When guests smoked in nonsmoking rooms fees could be substantial, but were often uncollected. Hotel smoking policies and their implementation fall short of protecting nonsmoking guests and workers from exposure to secondhand and thirdhand smoke. Complete indoor smoking bans for all hotels are needed to close existing loopholes. Nonsmokers who wish to protect themselves from exposure to tobacco smoke should avoid hotels that permit smoking and instead stay in completely smoke-free hotels.

Guest Controlled Nonmonotonic Deep Cavity Cavitand Assembly State Switching.

PubMed

Tang, Du; Barnett, J Wesley; Gibb, Bruce C; Ashbaugh, Henry S

2017-11-30

Octa-acid (OA) and tetra-endo-methyl octa-acid (TEMOA) are water-soluble, deep-cavity cavitands with nanometer-sized nonpolar pockets that readily bind complementary guests, such as n-alkanes. Experimentally, OA exhibits a progression of 1:1 to 2:2 to 2:1 host/guest complexes (X:Y where X is the number of hosts and Y is the number of guests) with increasing alkane chain length from methane to tetradecane. Differing from OA only by the addition of four methyl groups ringing the portal of the pocket, TEMOA exhibits a nonmonotonic progression of assembly states from 1:1 to 2:2 to 1:1 to 2:1 with increasing guest length. Here we present a systematic molecular simulation study to parse the molecular and thermodynamic determinants that distinguish the succession of assembly stoichiometries observed for these similar hosts. Potentials of mean force between hosts and guests, determined via umbrella sampling, are used to characterize association free energies. These free energies are subsequently used in a reaction network model to predict the equilibrium distributions of assemblies. Our models accurately reproduce the experimentally observed trends, showing that TEMOA's endo-methyl units constrict the opening of the binding pocket, limiting the conformations available to bound guests and disrupting the balance between monomeric complexes and dimeric capsules. The success of our simulations demonstrate their utility at interpreting the impact of even simple chemical modifications on supramolecular assembly and highlight their potential to aid bottom-up design.

Force and Stress along Simulated Dissociation Pathways of Cucurbituril-Guest Systems.

PubMed

Velez-Vega, Camilo; Gilson, Michael K

2012-03-13

The field of host-guest chemistry provides computationally tractable yet informative model systems for biomolecular recognition. We applied molecular dynamics simulations to study the forces and mechanical stresses associated with forced dissociation of aqueous cucurbituril-guest complexes with high binding affinities. First, the unbinding transitions were modeled with constant velocity pulling (steered dynamics) and a soft spring constant, to model atomic force microscopy (AFM) experiments. The computed length-force profiles yield rupture forces in good agreement with available measurements. We also used steered dynamics with high spring constants to generate paths characterized by a tight control over the specified pulling distance; these paths were then equilibrated via umbrella sampling simulations and used to compute time-averaged mechanical stresses along the dissociation pathways. The stress calculations proved to be informative regarding the key interactions determining the length-force profiles and rupture forces. In particular, the unbinding transition of one complex is found to be a stepwise process, which is initially dominated by electrostatic interactions between the guest's ammoniums and the host's carbonyl groups, and subsequently limited by the extraction of the guest's bulky bicyclooctane moiety; the latter step requires some bond stretching at the cucurbituril's extraction portal. Conversely, the dissociation of a second complex with a more slender guest is mainly driven by successive electrostatic interactions between the different guest's ammoniums and the host's carbonyl groups. The calculations also provide information on the origins of thermodynamic irreversibilities in these forced dissociation processes.

Conflicts of interest of editors of medical journals

PubMed Central

Minhajuddin, Abu

2018-01-01

Background Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. Methods We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology). Open Payments database was reviewed to determine the percentage of physician editors receiving payments and the nature and amount of these payments. Findings 703 unique physician editors were included in our analysis. 320/703 (46%) received 8659 general payments totaling $8,120,562. The median number of payments per editor was 9 (IQR 3–26) and the median amount per payment was $91 (IQR $21–441). The median total payment received by each editor in one year was $4,364 (IQR $319–23,143). 152 (48%) editors received payments more than $5,000 in a year, a threshold considered significant by the National Institutes of Health. COI policies for editors were available for 34/60 (57%) journals but only 7/34 (21%) publicly reported the disclosures and only 2 (3.%) reported the dollar amount received. Interpretation A significant number of editors of internal medicine and subspecialty medical journals have financial COI and very few are publicly disclosed. Specialty journal editors have more COI compared to general medicine journal editors. Current policies for disclosing COI for editors are inconsistent and do not comply with the recommended standards. PMID:29775468

New Editors Appointed for Sections of Journal of Geophysical Research

NASA Astrophysics Data System (ADS)

2009-04-01

New editors have been appointed for the Atmospheres, Biogeosciences, and Oceans sections of the Journal of Geophysical Research (JGR). Joost de Gouw (NOAA, Boulder, Colo.) and Renyi Zhang (Texas A&M, College Station) are filling the vacancies of retiring Atmospheres section editors John Austin and Jose Fuentes. De Gouw and Zhang join the continuing editors Steven Ghan and Yinon Rudich. Sara Pryor (Indiana University, Bloomington) is joining the Atmospheres section editorial board as an associate editor now; she will transition to editor in January 2010.

Energetics of small molecule and water complexation in hydrophobic calixarene cavities.

PubMed

Notestein, Justin M; Katz, Alexander; Iglesia, Enrique

2006-04-25

Calixarenes grafted on silica are energetically uniform hosts that bind aromatic guests with 1:1 stoichiometry, as shown by binding energies that depend upon the calixarene upper rim composition but not on their grafted surface density (0.02-0.23 nm(-2)). These materials are unique in maintaining a hydrophilic silica surface, as probed by H2O physisorption measurements, while possessing a high density of hydrophobic binding sites that are orthogonal to the silica surface below them. The covalently enforced cone-shaped cavities and complete accessibility of these rigidly grafted calixarenes allow the first unambiguous measurements of the thermodynamics of guest interaction with the same calixarene cavities in aqueous solution and vapor phase. Similar to adsorption into nonpolar protein cavities, adsorption into these hydrophobic cavities from aqueous solution is enthalpy-driven, which is in contrast to entropy-driven adsorption into water-soluble hydrophobic hosts such as beta cyclodextrin. The adsorption thermodynamics of several substituted aromatics from vapor and liquid are compared by (i) describing guest chemical potentials relative to pure guest, which removes differences among guests because of aqueous solvation and van der Waals contacts in the pure condensed phase, and (ii) passivating residual guest binding sites on exposed silica, titrated by water during adsorption from aqueous solution, using inorganic salts before vapor adsorption. Adsorption isotherms depend only upon the saturation vapor pressure of each guest, indicating that guest binding from aqueous or vapor media is controlled by van der Waals contacts with hydrophobic calixarene cavities acting as covalently assembled condensation nuclei, without apparent contributions from CH-pi or other directional interactions. These data also provide the first direct quantification of free energies for interactions of water with the calixarene cavity interior. The calixarene-water interface is stabilized by approximately 20 kJ/mol relative to the water-vapor interface, indicating that water significantly competes with the aromatic guests for adsorption at these ostensibly hydrophobic cavities. This result is useful for understanding models of water interactions with other concave hydrophobic surfaces, including those commonly observed within proteins.

Effects of multiple pathways on excited-state energy flow in self-assembled wheel-and-spoke light-harvesting architectures.

PubMed

Song, Hee-eun; Kirmaier, Christine; Schwartz, Jennifer K; Hindin, Eve; Yu, Lianhe; Bocian, David F; Lindsey, Jonathan S; Holten, Dewey

2006-10-05

Static and time-resolved optical measurements are reported for three cyclic hexameric porphyrin arrays and their self-assembled complexes with guest chromophores. The hexameric hosts contain zinc porphyrins and 0, 1, or 2 free base (Fb) porphyrins (denoted Zn(6), Zn(5)Fb, or Zn(4)Fb(2), respectively). The guest is a core-modified (O replacing one of the four N atoms) dipyridyl-substituted Fb porphyrin (DPFbO) that coordinates to zinc porphyrins of a host via pyridyl-zinc dative bonding. Each architecture is designed to have a gradient of excited-state energies for excitation funneling among the weakly coupled constituents of the host to the guest. Energy transfer to the lowest-energy chromophore(s) (coordinated zinc porphyrins or Fb porphyrins) within a hexameric host occurs primarily via a through-bond (TB) mechanism, is rapid ( approximately 40 ps), and is essentially quantitative (>or=98%). Energy transfer from a pyridyl-coordinated zinc porphyrin of the host to the guest in the Zn(6)*DPFbO complex has a yield of approximately 75%, a rate constant of approximately (0.7 ns)(-1), and significant Förster through-space (TS) character. In the case of Zn(5)Fb*DPFbO, which has an additional TS route via the Fb porphyrin with a rate constant of approximately (20 ns)(-1), the yield of energy transfer to the guest is somewhat lower ( approximately 50%) than that for Zn(6)*DPFbO. Complex Zn(4)Fb(2)*DPFbO has an identical TS pathway via the Fb porphyrin plus an additional TS pathway involving the second Fb porphyrin (closer to the guest) with a rate constant of approximately (0.5 ns)(-1). This complex exhibits an energy-transfer yield to the guest that is significantly enhanced over that for Zn(5)Fb*DPFbO and comparable to that for Zn(6)*DPFbO. Collectively, the results for the various arrays suggest designs for similar host-guest complexes that are expected to exhibit much more efficient light harvesting and excitation trapping at the central guest chromophore.

Journal Editors Celebrated at Editors' Evening

NASA Astrophysics Data System (ADS)

Panning, Jeanette

2014-02-01

At the Fall Meeting, the premiere social event for AGU's many journal editors is the annual Editors' Evening, an opportunity for members to celebrate and to recognize the efforts of retiring editors. At the event, AGU president Carol Finn welcomed all those in attendance and thanked them for volunteering their time for the benefit of AGU and the wider research community.

Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

ERIC Educational Resources Information Center

Amare, Nicole; Manning, Alan

2009-01-01

Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

EDITORIAL: Breeding new science by coupling photons with `nano'

NASA Astrophysics Data System (ADS)

Zheludev, Nikolay; Stockman, Mark; Zayats, Anatoly

2006-04-01

The new field of `nanophotonics' is concerned with the generation, transport, routing and detection of light in sub-wavelength structures. There is nothing new in the desire to use small structures to control waves that are much bigger than the structures, and the science of acoustics has been dealing with this problem since the early days of musical instruments. What makes nanophotonics so special is that it claims for optics the unexplored playfield of dimensions between those of objects the human eye can see with a lens, and those of the invisible elementary building blocks of the material world, molecules and atoms. Nanophotonics is a synthetic discipline that breaks into the fields of electrodynamics, solid state physics and laser physics. In growing from these disciplines it takes ideas from them, for instance from solid state physics by drawing analogies between electrons in crystals and photons in nanostructures, and from laser physics and traditional nonlinear optics by achieving strong fields not through an increase in optical power, but through its concentration. From an engineering perspective, nanophotonics promises to develop optical functionality on the smallest possible size scale (thus allowing for ultra-high-density integration), at the lowest possible energy level (thus allowing for single photon all-optical devices), and on the shortest possible timescale (thus allowing for optical devices operating within a single period of an optical wave). In this special issue we are, however, concerned with the fundamental aspects of nanophotonics, i.e. the physics that underpins these new, mind-boggling nanophotonic applications. This special issue opens with 4 articles derived from lectures at the Summer School Photonic Metamaterials: from Micro to Nanoscale, Erice, Italy, 1 7 August 2005. These reviews establish the hierarchy of nanophotonic structures and relevant length scales, explore wave interactions in nanostructured media, and examine nanophotonic functionalities underpinned by electronic excitations and structural transformations in nanoparticles. The main body of this special issue is a highly representative cross-section of research in the discipline, with papers covering essential issues in plasmonics, nanoparticle photonics, optical properties of nanostructured surfaces, atom manipulation on nanostructures, nonlinear interactions and Raman scattering from nanostructures, enhanced transmission through nano-perforated films, linear and nonlinear effects of planar chirality, energy transfer on the nanoscale, subwavelength spatial imaging, control of spontaneous emission and lasing in nanostructures and micro-resonators, nanophotonic sensors, nanostructured meta-materials, and novel nano-fabrication techniques. As the Guest Editors of this special issue, we are deeply grateful to all contributing authors for their efforts and their willingness to share recent results within the framework of what promises to be a treasured collection of papers in the field of nanophotonics. We are particularly proud that the authorship includes both pioneers and newcomers to this intriguing and fertile field of research. The Guest Editors would like to acknowledge the collaboration and support of Diederik Wiersma and Concita Sibilia, the directors of the Summer School Photonic Metamaterials: from Micro to Nanoscale, Erice, Italy, 1 7 August 2005, which provided review papers for this special issue. We are also grateful to the PHOREMOST, METAMORPHOSE and Plasmo-nano-devices European Networks of Excellence for promoting the idea of this special issue.

76 FR 44028 - Texas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

..., Dawson, Duval, Eastland, Garza, Glasscock, Hall, Hemphill, Hockley, Irion, Kent, King, Lynn, Martin, Mason, Mitchell, Moore, Motley, Pecos, Presidio, Scurry, Stephens, Sterling, Sutton, Terrell, Terry...

Nanoparticles functionalized with supramolecular host-guest systems for nanomedicine and healthcare.

PubMed

Wu, Zilong; Song, Nan; Menz, Ryan; Pingali, Bharadwaj; Yang, Ying-Wei; Zheng, Yuebing

2015-05-01

Synthetic macrocyclic host compounds can interact with suitable guest molecules via noncovalent interactions to form functional supramolecular systems. With the synergistic integration of the response of molecules and the unique properties at the nanoscale, nanoparticles functionalized with the host-guest supramolecular systems have shown great potentials for a broad range of applications in the fields of nanoscience and nanotechnology. In this review article, we focus on the applications of the nanoparticles functionalized with supramolecular host-guest systems in nanomedicine and healthcare, including therapeutic delivery, imaging, sensing and removal of harmful substances. A large number of examples are included to elucidate the working mechanisms, advantages, limitations and future developments of the nanoparticle-supramolecule systems in these applications.

Ancient Guest Stars as harbingers of neutron star formation

NASA Astrophysics Data System (ADS)

Wang, Zhen-Ru

The well-known AD 1006, 1054, 1572, and 1604 were described as "Guest Stars" by Chinese, Japanese and Korean. In most cases, it might thus be possible to expect a Guest Star to be a term for supernova or nova. There are a lot of records concerning ancient Guest Stars in Chinese historical books. Two catalogues were compiled by Xi (1955) and Xi and Bo (1965, 1966) that listed 90 probable novae or supernovae observed between 1400 BC and AD 1700. Clark and Stephenson (1977), Ho (1962) and Kanda (1935) collected more or less similar records. Among all the historical records more than 80% are from China. The discussion presented in this paper is based on them.

A Room with a Viewpoint Revisited: Descriptive Norms and Hotel Guests' Towel Reuse Behavior

PubMed Central

Bohner, Gerd; Schlüter, Lena E.

2014-01-01

Field experiments on descriptive norms as a means to increase hotel guests' towel reuse [1] were replicated and extended. In two hotels in Germany (Study 1: N = 724; Study 2: N = 204), descriptive norm messages suggesting that 75% of guests had reused their towels, or a standard message appealing to environmental concerns, were placed in guests' bathrooms. Descriptive norm messages varied in terms of proximity of the reference group (“hotel guests” vs. “guests in this room”) and temporal proximity (currently vs. two years previous). Reuse of towels was unobtrusively recorded. Results showed that reuse rates were high overall and that both standard and descriptive norm messages increased reuse rates compared to a no-message baseline. However, descriptive norm messages were not more effective than the standard message, and effects of proximity were inconsistent across studies. Discussion addresses cultural and conceptual issues in comparing the present findings with previous ones. PMID:25084348

Microimaging of transient guest profiles to monitor mass transfer in nanoporous materials

NASA Astrophysics Data System (ADS)

Kärger, Jörg; Binder, Tomas; Chmelik, Christian; Hibbe, Florian; Krautscheid, Harald; Krishna, Rajamani; Weitkamp, Jens

2014-04-01

The intense interactions of guest molecules with the pore walls of nanoporous materials is the subject of continued fundamental research. Stimulated by their thermal energy, the guest molecules in these materials are subject to a continuous, irregular motion, referred to as diffusion. Diffusion, which is omnipresent in nature, influences the efficacy of nanoporous materials in reaction and separation processes. The recently introduced techniques of microimaging by interference and infrared microscopy provide us with a wealth of information on diffusion, hitherto inaccessible from commonly used techniques. Examples include the determination of surface barriers and the sticking coefficient's analogue, namely the probability that, on colliding with the particle surface, a molecule may continue its diffusion path into the interior. Microimaging is further seen to open new vistas in multicomponent guest diffusion (including the detection of a reversal in the preferred diffusion pathways), in guest-induced phase transitions in nanoporous materials and in matching the results of diffusion studies under equilibrium and non-equilibrium conditions.

An organic dye-polymer (phenol red-poly (vinyl alcohol)) composite architecture towards tunable -optical and -saturable absorption characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sreedhar, Sreeja, E-mail: sreejasreedhar83@gmail.com; Muneera, C. I., E-mail: drcimuneera@hotmail.com; Illyaskutty, Navas

2016-05-21

Herein, we demonstrate that blending an organic dye (guest/filler), with a vinyl polymer (host template), is an inexpensive and simple approach for the fabrication of multifunctional photonic materials which could display an enhancement in the desirable properties of the constituent materials and, at the same time provide novel synergistic properties for the guest-host system. A new guest-host nanocomposite system comprising Phenol Red dye and poly (vinyl alcohol) as guest and host template, respectively, which exhibits tunable optical characteristics and saturable absorption behavior, is introduced. The dependence of local electronic environment provided by the polymer template and the interactions of themore » polymer molecules with the encapsulated guest molecules on the observed optical/nonlinear absorption behavior is discussed. An understanding of the tunability of the optical/ photophysical processes, with respect to the filler content, as discussed herein could help in the design of improved optical materials for several photonic device applications like organic light emitting diodes and saturable absorbers.« less

76 FR 47637 - Kansas Disaster #KS-00055

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... disaster declaration on 07/29/2011, Private Non- Profit organizations that provide essential services of... Counties: Barton, Clay, Cloud, Hamilton, Jewell, Lincoln, Logan, Lyon, Marion, Mitchell, Morton, Osage...

Identification of Guest-Host Inclusion Complexes in the Gas Phase by Electrospray Ionization-Mass Spectrometry

ERIC Educational Resources Information Center

Mendes, De´bora C.; Ramamurthy, Vaidhyanathan; Da Silva, Jose´ P.

2015-01-01

In this laboratory experiment, students follow a step-by-step procedure to prepare and study guest-host complexes in the gas phase using electrospray ionization-mass spectrometry (ESI-MS). Model systems are the complexes of hosts cucurbit[7]uril (CB7) and cucurbit[8]uril (CB8) with the guest 4-styrylpyridine (SP). Aqueous solutions of CB7 or CB8…

COFS 1 Guest Investigator Program

NASA Technical Reports Server (NTRS)

Fontana, Anthony; Wright, Robert L.

1986-01-01

The process for selecting guest investigators for participation in the Control of Flexible Structures (COFS)-1 program is described. Contracts and grants will be awarded in late CY87. A straw-man list of types of experiments and a distribution of the experiments has been defined to initiate definition of an experiments package which supports development and validation of control structures interaction technology. A schedule of guest investigator participation has been developed.

Making Math Real: Effective Qualities of Guest Speaker Presentations and the Impact of Speakers on Student Attitude and Achievement in the Algebra Classroom

ERIC Educational Resources Information Center

McKain, Danielle R.

2012-01-01

The term real world is often used in mathematics education, yet the definition of real-world problems and how to incorporate them in the classroom remains ambiguous. One way real-world connections can be made is through guest speakers. Guest speakers can offer different perspectives and share knowledge about various subject areas, yet the impact…

Host-guest chemistry of dendrimer-drug complexes: 7. Formation of stable inclusions between acetylated dendrimers and drugs bearing multiple charges.

PubMed

Fang, Min; Zhang, Jiahai; Wu, Qinglin; Xu, Tongwen; Cheng, Yiyun

2012-03-15

Drug molecules bearing multiple charges usually form precipitates with cationic dendrimers, which presents a challenge during the preparation of dendrimer inclusions for these drugs. In the present study, fully acetylated polyamidoamine (PAMAM) dendrimers were proposed as stable vehicles for drug molecules bearing two negative charges such as Congo red and indocyanine green. NMR techniques including (1)H NMR and (1)H-(1)H NOESY were used to characterize the host-guest chemistry of acetylated dendrimer and these guest molecules. The cationic PAMAM dendrimer was found to form a precipitate with Congo red and indocyanine green, but the acetylated one avoided the formation of cross-linking structures in aqueous solutions. NOESY studies revealed the encapsulation of Congo red and indocyanine green within the interior cavities of PAMAM dendrimers at mild acidic conditions and acetylated dendrimers show much stronger ability to encapsulate the guest molecules than cationic ones. Also, UV-vis-NIR studies suggest that acetylated dendrimers significantly improve the photostability of indocyanine green and prevent the formation of indocyanine green J-aggregates in aqueous solutions. The present study provides a new insight into dendrimer-based host-guest systems, especially for those guest molecules bearing multiple charges. © 2012 American Chemical Society

Multiscale and Multifunctional Emulsions by Host–Guest Interaction-Mediated Self-Assembly

PubMed Central

2018-01-01

Emulsions are widely used in numerous fields. Therefore, there has been increasing interest in the development of new emulsification strategies toward emulsions with advanced functions. Herein we report the formation of diverse emulsions by host–guest interaction-mediated interfacial self-assembly under mild conditions. In this strategy, a hydrophilic diblock copolymer with one block containing β-cyclodextrin (β-CD) can assemble at the oil/water interface when its aqueous solution is mixed with an oil phase of benzyl alcohol (BA), by host–guest interactions between β-CD and BA. This results in significantly reduced interfacial tension and the formation of switchable emulsions with easily tunable droplet sizes. Furthermore, nanoemulsions with excellent stability are successfully prepared simply via vortexing. The self-assembled oil-in-water emulsions also show catastrophic phase inversion, which can generate stable bicontinuous phase and water-in-oil emulsions, thereby further extending phase structures that can be realized by this host–guest self-assembly approach. Moreover, the host–guest nanoemulsions are able to engineer different nanoparticles and microstructures as well as solubilize a diverse array of hydrophobic drugs and dramatically enhance their oral bioavailability. The host–guest self-assembly emulsification is facile, energetically friendly, and fully translatable to industry, therefore representing a conceptually creative approach toward advanced emulsions. PMID:29806006

No evidence of transmission from an acute case of hepatitis A in a foodhandler: follow-up of almost 1,000 potentially exposed individuals, London, United Kingdom, April 2012.

PubMed

Hall, V; Abrahams, A; Turbitt, D; Cathcart, S; Maguire, H; Balasegaram, S

2014-07-31

Identification of acute hepatitis A virus (HAV) infection in a foodhandler in a London hotel led to a large incident response. We identified three potentially exposed groups: hotel staff who had regularly consumed food prepared by the case and shared toilet facilities with the case, patients who shared the same hospital ward as the case and hotel guests who consumed food prepared by the case. We arranged post-exposure HAV vaccination for all 83 potentially exposed hotel staff and all 17 patients. We emailed 887 guests advising them to seek medical care if symptomatic, but did not advise vaccination as it was too late to be effective for most guests. Through the International Health Regulations national focal points and the European Union Early warning and response system (EWRS), we communicated the details of the incident to public health agencies and potential risk of HAV transmission to international guests. Potentially exposed hotel staff and guests were asked to complete an online or telephone-administered questionnaire 50 days following possible exposure, to identify any secondary cases. Survey response was low, with 155 responses from guests and 33 from hotel staff. We identified no secondary cases of HAV infection through follow-up.

Effects of guest feeding programs on captive giraffe behavior.

PubMed

Orban, David A; Siegford, Janice M; Snider, Richard J

2016-01-01

Zoological institutions develop human-animal interaction opportunities for visitors to advance missions of conservation, education, and recreation; however, the animal welfare implications largely have yet to be evaluated. This behavioral study was the first to quantify impacts of guest feeding programs on captive giraffe behavior and welfare, by documenting giraffe time budgets that included both normal and stereotypic behaviors. Thirty giraffes from nine zoos (six zoos with varying guest feeding programs and three without) were observed using both instantaneous scan sampling and continuous behavioral sampling techniques. All data were collected during summer 2012 and analyzed using linear mixed models. The degree of individual giraffe participation in guest feeding programs was positively associated with increased time spent idle and marginally associated with reduced time spent ruminating. Time spent participating in guest feeding programs had no effect on performance of stereotypic behaviors. When time spent eating routine diets was combined with time spent participating in guest feeding programs, individuals that spent more time engaged in total feeding behaviors tended to perform less oral stereotypic behavior such as object-licking and tongue-rolling. By extending foraging time and complexity, guest feeding programs have the potential to act as environmental enrichment and alleviate unfulfilled foraging motivations that may underlie oral stereotypic behaviors observed in many captive giraffes. However, management strategies may need to be adjusted to mitigate idleness and other program consequences. Further studies, especially pre-and-post-program implementation comparisons, are needed to better understand the influence of human-animal interactions on zoo animal behavior and welfare. © 2016 Wiley Periodicals, Inc.

Molecular structures of the inclusion complexes beta-cyclodextrin-1,2-bis(4-aminophenyl)ethane and beta-cyclodextrin-4,4'-diaminobiphenyl; packing of dimeric beta-cyclodextrin inclusion complexes.

PubMed

Giastas, Petros; Yannakopoulou, Konstantina; Mavridis, Irene M

2003-04-01

The present investigation is part of an ongoing study on the influence of the long end-functonalized guest molecules DBA and BNZ in the crystal packing of beta-cyclodextrin (betaCD) dimeric complexes. The title compounds are 2:2 host:guest complexes showing limited host-guest hydrogen bonding at the primary faces of the betaCD dimers. Within the betaCD cavity the guests exhibit mutual pi...pi interactions and between betaCD dimers perpendicular NH...pi interactions. The DBA guest molecule exhibits one extended and two bent conformations in the complex. The BNZ guest molecule is not planar inside betaCD, in contrast to the structure of BNZ itself, which indicates that the cavity isolates the molecules and forbids the pi...pi stacking of the aromatic rings. NMR spectroscopy studies show that in aqueous solution both DBA and BNZ form strong complexes that have 1:1 stoichiometry and structures similar to the solid state ones. The relative packing of the dimers is the same in both complexes. The axes of two adjacent dimers form an angle close to 20 degrees and have a lateral displacement approximately 2.45 A, both of which characterize the screw-channel mode of packing. Although the betaCD/BNZ complex indeed crystallizes in a space group characterizing the latter mode, the betaCD/DBA complex crystallizes in a space group with novel dimensions not resembling any of the packing modes reported so far. The new lattice is attributed to the three conformations exhibited by the guest in the crystals. However, this lattice can be transformed into another, which is isostructural to that of the betaCD/BNZ inclusion complex, if the conformation of the guest is not taken into account.

A structural model of polyglutamine determined from a host-guest method combining experiments and landscape theory.

PubMed

Finke, John M; Cheung, Margaret S; Onuchic, José N

2004-09-01

Modeling the structure of natively disordered peptides has proved difficult due to the lack of structural information on these peptides. In this work, we use a novel application of the host-guest method, combining folding theory with experiments, to model the structure of natively disordered polyglutamine peptides. Initially, a minimalist molecular model (C(alpha)C(beta)) of CI2 is developed with a structurally based potential and captures many of the folding properties of CI2 determined from experiments. Next, polyglutamine "guest" inserts of increasing length are introduced into the CI2 "host" model and the polyglutamine is modeled to match the resultant change in CI2 thermodynamic stability between simulations and experiments. The polyglutamine model that best mimics the experimental changes in CI2 thermodynamic stability has 1), a beta-strand dihedral preference and 2), an attractive energy between polyglutamine atoms 0.75-times the attractive energy between the CI2 host Go-contacts. When free-energy differences in the CI2 host-guest system are correctly modeled at varying lengths of polyglutamine guest inserts, the kinetic folding rates and structural perturbation of these CI2 insert mutants are also correctly captured in simulations without any additional parameter adjustment. In agreement with experiments, the residues showing structural perturbation are located in the immediate vicinity of the loop insert. The simulated polyglutamine loop insert predominantly adopts extended random coil conformations, a structural model consistent with low resolution experimental methods. The agreement between simulation and experimental CI2 folding rates, CI2 structural perturbation, and polyglutamine insert structure show that this host-guest method can select a physically realistic model for inserted polyglutamine. If other amyloid peptides can be inserted into stable protein hosts and the stabilities of these host-guest mutants determined, this novel host-guest method may prove useful to determine structural preferences of these intractable but biologically relevant protein fragments.

Supramolecular chemistry at interfaces: host-guest interactions for fabricating multifunctional biointerfaces.

PubMed

Yang, Hui; Yuan, Bin; Zhang, Xi; Scherman, Oren A

2014-07-15

CONSPECTUS: Host-guest chemistry can greatly improve the selectivity of biomolecule-ligand binding on account of recognition-directed interactions. In addition, functional structures and the actuation of supramolecular assemblies in molecular systems can be controlled efficiently through various host-guest chemistry. Together, these highly selective, strong yet dynamic interactions can be exploited as an alternative methodology for applications in the field of programmable and controllable engineering of supramolecular soft materials through the reversible binding between complementary components. Many processes in living systems such as biotransformation, transportation of matter, and energy transduction begin with interfacial molecular recognition, which is greatly influenced by various external stimuli at biointerfaces. Detailed investigations about the molecular recognition at interfaces can result in a better understanding of life science, and further guide us in developing new biomaterials and medicines. In order to mimic complicated molecular-recognition systems observed in nature that adapt to changes in their environment, combining host-guest chemistry and surface science is critical for fabricating the next generation of multifunctional biointerfaces with efficient stimuli-responsiveness and good biocompatibility. In this Account, we will summarize some recent progress on multifunctional stimuli-responsive biointerfaces and biosurfaces fabricated by cyclodextrin- or cucurbituril-based host-guest chemistry and highlight their potential applications including drug delivery, bioelectrocatalysis, and reversible adsorption and resistance of peptides, proteins, and cells. In addition, these biointerfaces and biosurfaces demonstrate efficient response toward various external stimuli, such as UV light, pH, redox chemistry, and competitive guests. All of these external stimuli can aid in mimicking the biological stimuli evident in complex biological environments. We begin by reviewing the current state of stimuli-responsive supramolecular assemblies formed by host-guest interactions, discussing how to transfer host-guest chemistry from solution onto surfaces required for fabricating multifunctional biosurfaces and biointerfaces. Then, we present different stimuli-responsive biosurfaces and biointerfaces, which have been prepared through a combination of cyclodextrin- or cucurbituril-based host-guest chemistry and various surface technologies such as self-assembled monolayers or layer-by-layer assembly. Moreover, we discuss the applications of these biointerfaces and biosurfaces in the fields of drug release, reversible adsorption and release of some organic molecules, peptides, proteins, and cells, and photoswitchable bioelectrocatalysis. In addition, we summarize the merits and current limitations of these methods for fabricating multifunctional stimuli-responsive biointerfaces in a dynamic noncovalent manner. Finally, we present possible strategies for future designs of stimuli-responsive multifunctional biointerfaces and biosurfaces by combining host-guest chemistry with surface science, which will lead to further critical development of supramolecular chemistry at interfaces.

Rotaxane and catenane host structures for sensing charged guest species.

PubMed

Langton, Matthew J; Beer, Paul D

2014-07-15

CONSPECTUS: The promise of mechanically interlocked architectures, such as rotaxanes and catenanes, as prototypical molecular switches and shuttles for nanotechnological applications, has stimulated an ever increasing interest in their synthesis and function. The elaborate host cavities of interlocked structures, however, can also offer a novel approach toward molecular recognition: this Account describes the use of rotaxane and catenane host systems for binding charged guest species, and for providing sensing capability through an integrated optical or electrochemical reporter group. Particular attention is drawn to the exploitation of the unusual dynamic properties of interlocked molecules, such as guest-induced shuttling or conformational switching, as a sophisticated means of achieving a selective and functional sensor response. We initially survey interlocked host systems capable of sensing cationic guests, before focusing on our accomplishments in synthesizing rotaxanes and catenanes designed for the more challenging task of selective anion sensing. In our group, we have developed the use of discrete anionic templation to prepare mechanically interlocked structures for anion recognition applications. Removal of the anion template reveals an interlocked host system, possessing a unique three-dimensional geometrically restrained binding cavity formed between the interlocked components, which exhibits impressive selectivity toward complementary anionic guest species. By incorporating reporter groups within such systems, we have developed both electrochemical and optical anion sensors which can achieve highly selective sensing of anionic guests. Transition metals, lanthanides, and organic fluorophores integrated within the mechanically bonded structural framework of the receptor are perturbed by the binding of the guest, with a concomitant change in the emission profile. We have also exploited the unique dynamics of interlocked hosts by demonstrating that an anion-induced conformational change can be used as a means of signal transduction. Electrochemical sensing has been realized by integration of the redox-active ferrocene functionality within a range of rotaxane and catenanes; binding of an anion perturbs the metallocene, leading to a cathodic shift in the ferrocene/ferrocenium redox couple. In order to obtain practical sensors for target charged guest species, confinement of receptors at a surface is necessary in order to develop robust, reuseable devices. Surface confinement also offers advantages over solution based receptors, including amplification of signal, enhanced guest binding thermodynamics and the negation of solubility problems. We have fabricated anion-templated rotaxanes and catenanes on gold electrode surfaces and demonstrated that the resulting mechanically bonded self-assembled monolayers are electrochemically responsive to the binding of anions, a crucial first step toward the advancement of sophisticated, highly selective, anion sensory devices. Rotaxane and catenane host molecules may be engineered to offer a superior level of molecular recognition, and the incorporation of optical or electrochemical reporter groups within these interlocked frameworks can allow for guest sensing. Advances in synthetic templation strategies has facilitated the synthesis of interlocked architectures and widened their interest as prototype molecular machines. However, their unique host-guest properties are only now beginning to be exploited as a sophisticated approach to chemical sensing. The development of functional host-guest sensory systems such as these is of great interest to the interdisciplinary field of supramolecular chemistry.

Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins.

PubMed

Mailloux, Ryan J; Harper, Mary-Ellen

2012-09-01

Fifty years since Peter Mitchell proposed the theory of chemiosmosis, the transformation of cellular redox potential into ATP synthetic capacity is still a widely recognized function of mitochondria. Mitchell used the term 'proticity' to describe the force and flow of the proton circuit across the inner membrane. When the proton gradient is coupled to ATP synthase activity, the conversion of fuel to ATP is efficient. However, uncoupling proteins (UCPs) can cause proton leaks resulting in poor fuel conversion efficiency, and some UCPs might control mitochondrial reactive oxygen species (ROS) production. Once viewed as toxic metabolic waste, ROS are now implicated in cell signaling and regulation. Here, we discuss the role of mitochondrial proticity in the context of ROS production and signaling. Copyright © 2012 Elsevier Ltd. All rights reserved.

Mitchell Receives 2013 Ronald Greeley Early Career Award in Planetary Science: Citation

NASA Astrophysics Data System (ADS)

McKinnon, William B.

2014-07-01

The Greeley Early Career Award is named for pioneering planetary scientist Ronald Greeley. Ron was involved in nearly every major planetary mission from the 1970s until his death and was extraordinarily active in service to the planetary science community. Ron's greatest legacies, however, are those he mentored through the decades, and it is young scientists whose work and promise we seek to recognize. This year's Greeley award winner is Jonathan L. Mitchell, an assistant professor at the University of California, Los Angeles (UCLA). Jonathan received his Ph.D. from the University of Chicago, and after a postdoc at the Institute for Advanced Studies in Princeton, he joined the UCLA faculty, where he holds a joint appointment in Earth and space sciences and in atmospheric sciences.

Television transmission at end of second extravehicular activity

NASA Image and Video Library

1971-02-06

S71-20784 (5 Feb. 1971) --- Astronaut Alan B. Shepard Jr., Apollo 14 commander, can be seen preparing to swing at a golf ball during a television transmission near the close of the second Extravehicular Activity (EVA-2) at the Apollo 14 Fra Mauro landing site. Shepard is using a real golf ball and an actual six iron, attached to the end of the handle for the contingency sample return. Astronaut Edgar D. Mitchell, lunar module pilot, looks on. Also visible in the picture is the erectable S-Band antenna (left foreground). Astronaut Stuart A. Roosa, command module pilot, remained with the Command and Service Modules (CSM) in lunar orbit, while Shepard and Mitchell descended in the Lunar Module (LM) to explore the moon. Photo credit: NASA or National Aeronautics and Space Administration

Mission Control Center (MCC): Apollo XV - MSC

NASA Image and Video Library

1971-08-02

S71-41759 (2 Aug. 1971) --- A partial view of activity in the Mission Operations Control Room in the Mission Control Center during the liftoff of the Apollo 15 Lunar Module "Falcon" ascent stage from the lunar surface. An RCA color television camera mounted on the Lunar Roving Vehicle made it possible for people on Earth to watch the LM's spectacular launch from the moon. The LM liftoff was at 171:37 ground elapsed time. The LRV was parked about 300 feet east of the LM. The TV camera was remotely controlled from a console in the MOCR. Seated in the right foreground is astronaut Edgar D. Mitchell, a spacecraft communicator. Mitchell was lunar module pilot of the Apollo 14 lunar landing mission. Note liftoff on the television monitor in the center background.

Preparation and characterization of multi stimuli-responsive photoluminescent nanocomposites of graphene quantum dots with hyperbranched polyethylenimine derivatives

NASA Astrophysics Data System (ADS)

Liu, Xing; Liu, Hua-Ji; Cheng, Fa; Chen, Yu

2014-06-01

Oxidized graphene sheets (OGS) were treated with a hyperbranched polyethylenimine (PEI) under hydrothermal conditions to generate nanocomposites of graphene quantum dots (GQDs) functionalized with PEI (GQD-PEIs). The influence of the reaction temperature and the PEI/OGS feed ratio on the photoluminescence properties of the GQD-PEIs was studied. The obtained GQD-PEIs were characterized by TEM, dynamic light scattering, elemental analysis, FTIR, zeta potential measurements and 1H NMR spectroscopy, from which their structural information was inferred. Subsequently, isobutyric amide (IBAm) groups were attached to the GQD-PEIs through the amidation reaction of isobutyric anhydride with the PEI moieties, which resulted in GQD-PEI-IBAm nanocomposites. GQD-PEI-IBAm was not only thermoresponsive, but also responded to other stimuli, including inorganic salts, pH, and loaded organic guests. The cloud point temperature (Tcp) of aqueous solutions of GQD-PEI-IBAm could be modulated through changing the number of IBAm units in GQD-PEI-IBAm, by varying the type and concentration of the inorganic salts and loaded organic guests, or by varying the pH. All the obtained GQD-PEI-IBAm nanocomposites were photoluminescent, and their maximum emission wavelengths were not influenced by outside stimuli. Their emission intensities were influenced a little or negligibly by pH, traditional salting-out anions (Cl- and SO42-), and the relatively polar aspirin guest. However, the traditional salting-in I- anion and the more hydrophobic 1-pyrenebutyric acid (PBA) guest could effectively quench their fluorescence. 2D NOESY 1H NMR spectra verified that GQD-PEI-IBAm accommodated the relatively polar aspirin guest using the PEI-IBAm shell, but adsorbed the relatively hydrophobic PBA guest through the nanographene core. The release rate of the guest encapsulated by the thermoresponsive GQD is different below and above Tcp.Oxidized graphene sheets (OGS) were treated with a hyperbranched polyethylenimine (PEI) under hydrothermal conditions to generate nanocomposites of graphene quantum dots (GQDs) functionalized with PEI (GQD-PEIs). The influence of the reaction temperature and the PEI/OGS feed ratio on the photoluminescence properties of the GQD-PEIs was studied. The obtained GQD-PEIs were characterized by TEM, dynamic light scattering, elemental analysis, FTIR, zeta potential measurements and 1H NMR spectroscopy, from which their structural information was inferred. Subsequently, isobutyric amide (IBAm) groups were attached to the GQD-PEIs through the amidation reaction of isobutyric anhydride with the PEI moieties, which resulted in GQD-PEI-IBAm nanocomposites. GQD-PEI-IBAm was not only thermoresponsive, but also responded to other stimuli, including inorganic salts, pH, and loaded organic guests. The cloud point temperature (Tcp) of aqueous solutions of GQD-PEI-IBAm could be modulated through changing the number of IBAm units in GQD-PEI-IBAm, by varying the type and concentration of the inorganic salts and loaded organic guests, or by varying the pH. All the obtained GQD-PEI-IBAm nanocomposites were photoluminescent, and their maximum emission wavelengths were not influenced by outside stimuli. Their emission intensities were influenced a little or negligibly by pH, traditional salting-out anions (Cl- and SO42-), and the relatively polar aspirin guest. However, the traditional salting-in I- anion and the more hydrophobic 1-pyrenebutyric acid (PBA) guest could effectively quench their fluorescence. 2D NOESY 1H NMR spectra verified that GQD-PEI-IBAm accommodated the relatively polar aspirin guest using the PEI-IBAm shell, but adsorbed the relatively hydrophobic PBA guest through the nanographene core. The release rate of the guest encapsulated by the thermoresponsive GQD is different below and above Tcp. Electronic supplementary information (ESI) available: Elemental analysis data; typical FTIR spectra; typical photographs of the GQD solution before and after phase transition; typical luminescence photographs, and typical photoluminescence spectra. See DOI: 10.1039/c4nr00739e

Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex.

PubMed

Xia, Yu; Wang, Chuan-Zeng; Tian, Mengkui; Tao, Zhu; Ni, Xin-Long; Prior, Timothy J; Redshaw, Carl

2018-01-15

The host-guest interaction of a series of cyclohexyl-appended guests with cucurbit[8]uril (Q[8]) was studied by ¹H NMR spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The X-ray structure revealed that two cycloalkane moieties can be simultaneously encapsulated in the hydrophobic cavity of the Q[8] host to form a ternary complex for the first time.

Diffusion of vaporous guests into a seemingly non-porous organic crystal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herbert, Simon A.; Janiak, Agnieszka; Thallapally, Praveen K.

2014-10-07

In this research, the tetragonal apohost phase of p-tert-butyltetramethoxythiacalix[4]arene absorbs hydrochloric acid and iodine. These guest molecules occupy different sites in the solid-state structure -- either within the small intrinsic voids of the macrocycle or within the interstitial spaces between the host molecules. This study illustrates the dynamic deformation of the host, providing strong mechanistic insight into the diffusion of guests into this seemingly non-porous material.

Host-guest capability of a three-dimensional heterometallic macrocycle.

PubMed

Fan, Qi-Jia; Lin, Yue-Jian; Hahn, F Ekkehardt; Jin, Guo-Xin

2018-02-13

A three-dimensional heterometallic coordination macrocycle is found to be capable of encapsulating planar pyrene (G1), coronene (G4) and non-planar corannulene (G2) guest molecules in high yields, giving rise to 1 : 1 host-guest complexes. The bowl-shaped guest corannulene is found to be significantly flattened upon inclusion within the cavity. However, macrocyclic compounds with larger cavity sizes, which form 1 : 1 stoichiometry assemblies with a naphthalene bisimide planar molecule (G3), are more inclined to form infinite sandwich structures. Furthermore, these heterometallic coordination macrocycles can be destroyed in the presence of a soft base to form hexanuclear triangular prism complexes. These structures are unambiguously revealed by single-crystal X-ray analysis.

Test Plans and Procedures for the Baseline SAF for BDS-D Sites (ModSAF). Volume 2

DTIC Science & Technology

1993-12-20

operations editor will no longer editor, appear in the EditorI Area. 64 I ADST/WDL/TR-93-W003271 VOLUME 2 of 2; Ver 1.0I 44200 Repeat steps 44120 thru...The unit operations 44200 to task the orange editor will no longer platoon to Move on the appear in the Editor route labeled "ort. Area. The vehicles

Strategic Studies Quarterly. Volume 2, Number 3, Fall 2008

DTIC Science & Technology

2008-01-01

Managing Editor Betty R. Littlejohn, Editorial Assistant Jerry L. Gantt, Content Editor Sherry Terrell , Editorial Assistant Steven C. Garst...factsheet.asp?id=107 . Ibid. 9. Lt Col Sebastian M. Convertino II, CDR Lou Anne DeMattei, and Lt Col Tammy Knierim, Flying and Fighting in...PhD, Editor-in-Chief L. Tawanda Eaves, Managing Editor Betty R. Littlejohn, Editorial Assistant Jerry L. Gantt, Content Editor Sherry Terrell

75 FR 43995 - Advisory Committee on Immunization Practices (ACIP)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

...: The conference call will originate at the National Center for Immunization and Respiratory Diseases in.... CONTACT PERSON FOR MORE INFORMATION: Leola Mitchell, National Center for Immunization and Respiratory...

The ICMJE Recommendations and pharmaceutical marketing--strengths, weaknesses and the unsolved problem of attribution in publication ethics.

PubMed

Matheson, Alastair

2016-04-04

The International Committee of Medical Journal Editors (ICMJE) Recommendations set ethical and editorial standards for article publication in most leading medical journals. Here, I examine the strengths and weaknesses of the Recommendations in the prevention of commercial bias in industry-financed journal literature, on three levels - scholarly discourse, article content, and article attribution. With respect to overall discourse, the most important measures in the ICMJE Recommendations are for enforcing clinical trial registration and controlling duplicate publication. With respect to article content, the ICMJE promotes stringent author accountability and adherence to established reporting standards. However, the ICMJE accepts the use of commercial editorial teams to produce manuscripts, which is a potential source of bias, and accepts private company ownership and analysis of clinical trial data. New ICMJE guidance on data sharing will address but not eliminate problems of commercial data access. With respect to attribution, the Recommendations oppose guest authorship and encourage clear documentation of author contributions. However, they exclude writers from coauthorship; provide no specific advice on the attribution of commercial literature, for instance with respect to company authorship, author sequence or prominent commercial labeling; and endorse the use of fine print and euphemism. The ICMJE requires detailed author interest disclosures, but overlooks the interests of non-authors and companies, and does not recommend that interests most salient to the publication are highlighted. Together, these weaknesses facilitate "advocacy"-based marketing, in which literature planned, financed and produced by companies is fronted by academics, enabling commercial messages to be presented to customers by their respected clinical peers rather than companies themselves. The ICMJE Recommendations set important research and reporting standards, without which commercial bias would likely be a significantly greater problem than it is today. However, they also support practices of commercial data control, content development and attribution that run counter to science's values of openness, objectivity and truthfulness. These weaknesses could be addressed with appropriate modifications to the Recommendations. The ICMJE should also disclose its own commercial interests and funding - not least because publishing organizations that finance it and pay the salaries of some member editors derive substantial revenues from industry.

3D nitrogen-doped graphene/β-cyclodextrin: host-guest interactions for electrochemical sensing

NASA Astrophysics Data System (ADS)

Liu, Jilun; Leng, Xuanye; Xiao, Yao; Hu, Chengguo; Fu, Lei

2015-07-01

Host-guest interactions, especially those between cyclodextrins (CDs, including α-, β- and γ-CD) and various guest molecules, exhibit a very high supramolecular recognition ability. Thus, they have received considerable attention in different fields. These specific interactions between host and guest molecules are promising for biosensing and clinical detection. However, there is a lack of an ideal electrode substrate for CDs to increase their performance in electrochemical sensing. Herein, we propose a new 3D nitrogen-doped graphene (3D-NG) based electrochemical sensor, taking advantage of the superior sensitivity of host-guest interactions. Our 3D-NG was fabricated by a template-directed chemical vapour deposition (CVD) method, and it showed a large specific surface area, a high capacity for biomolecules and a high electron transfer efficiency. Thus, for the first time, we took 3D-NG as an electrode substrate for β-CD to establish a new type of biosensor. Using dopamine (DA) and acetaminophen (APAP) as representative guest molecules, our 3D-NG/β-CD biosensor shows extremely high sensitivities (5468.6 μA mM-1 cm-2 and 2419.2 μA mM-1 cm-2, respectively), which are significantly higher than those reported in most previous studies. The stable adsorption of β-CD on 3D-NG indicates potential applications in clinical detection and medical testing.Host-guest interactions, especially those between cyclodextrins (CDs, including α-, β- and γ-CD) and various guest molecules, exhibit a very high supramolecular recognition ability. Thus, they have received considerable attention in different fields. These specific interactions between host and guest molecules are promising for biosensing and clinical detection. However, there is a lack of an ideal electrode substrate for CDs to increase their performance in electrochemical sensing. Herein, we propose a new 3D nitrogen-doped graphene (3D-NG) based electrochemical sensor, taking advantage of the superior sensitivity of host-guest interactions. Our 3D-NG was fabricated by a template-directed chemical vapour deposition (CVD) method, and it showed a large specific surface area, a high capacity for biomolecules and a high electron transfer efficiency. Thus, for the first time, we took 3D-NG as an electrode substrate for β-CD to establish a new type of biosensor. Using dopamine (DA) and acetaminophen (APAP) as representative guest molecules, our 3D-NG/β-CD biosensor shows extremely high sensitivities (5468.6 μA mM-1 cm-2 and 2419.2 μA mM-1 cm-2, respectively), which are significantly higher than those reported in most previous studies. The stable adsorption of β-CD on 3D-NG indicates potential applications in clinical detection and medical testing. Electronic supplementary information (ESI) available: The procedure for preparing the sensor, wide survey XPS, XRD patterns, the effect of scan rate, more CV data on the stability and selectivity, and a comparison with previous studies. See DOI: 10.1039/c5nr03109e

Editorial independence at medical journals owned by professional associations: a survey of editors.

PubMed

Davis, Ronald M; Müllner, Marcus

2002-10-01

The purpose of this study was to assess the degree of editorial independence at a sample of medical journals and the relationship between the journals and their owners. We surveyed the editors of 33 medical journals owned by not-for-profit organizations ("associations"), including 10 journals represented on the International Committee of Medical Journal Editors (nine of which are general medical journals) and a random sample of 23 specialist journals with high impact factors that are indexed by the Institute for Scientific Information. The main outcome measures were the authority to hire, fire, and oversee the work of the editor; the editor's tenure and financial compensation; control of the journal's budget; publication of material about the association; and the editor's perceptions about editorial independence and pressure over editorial content. Of the 33 editors, 23 (70%) reported having complete editorial freedom, and the remainder reported a high level of freedom (a score of > or = 8, where 10 equals complete editorial freedom and 1 equals no editorial freedom). Nevertheless, a substantial minority of editors reported having received at least some pressure in recent years over editorial content from the association's leadership (42%), senior staff (30%), or rank-and-file members (39%). The association's board of directors has the authority to hire (48%) or fire (55%) the editor for about half of the journals, and the editor reports to the board for 10 journals (30%). Twenty-three editors (70%) are appointed for a specific term (median term = 5 years). Three-fifths of the journals have no control over their profit, and the majority of journals use the association's legal counsel and/or media relations staff. Stronger safeguards are needed to give editors protection against pressure over editorial content, including written guarantees of editorial freedom and governance structures that support those guarantees. Strong safeguards are also needed because editors may have less freedom than they believe (especially if they have not yet tested their freedom in an area of controversy).

Reflections on 35 years with Applied Optics: outgoing editorial.

PubMed

Mait, Joseph N

2014-10-20

Applied Optics' Editor-in-Chief, Joseph N. Mait reflects on his experience as a reader, author, reviewer and eventual editor of the journal. Dr. Mait also introduces the incoming Editor-in-Chief, Ronald G. Driggers and acknowledges outgoing Division Editor, T.-C. Poon.

Combined analysis of 1,3-benzodioxoles by crystalline sponge X-ray crystallography and laser desorption ionization mass spectrometry.

PubMed

Hayashi, Yukako; Ohara, Kazuaki; Taki, Rika; Saeki, Tomomi; Yamaguchi, Kentaro

2018-03-12

The crystalline sponge (CS) method, which employs single-crystal X-ray diffraction to determine the structure of an analyte present as a liquid or an oil and having a low melting point, was used in combination with laser desorption ionization mass spectrometry (LDI-MS). 1,3-Benzodioxole derivatives were encapsulated in CS and their structures were determined by combining X-ray crystallography and MS. After the X-ray analysis, the CS was subjected to imaging mass spectrometry (IMS) with an LDI spiral-time-of-flight mass spectrometer (TOF-MS). The ion detection area matched the microscopic image of the encapsulated CS. In addition, the accumulated 1D mass spectra showed that fragmentation of the guest molecule (hereafter, guest) can be easily visualized without any interference from the fragment ions of CS except for two strong ion peaks derived from the tridentate ligand TPT (2,4,6-tris(4-pyridyl)-1,3,5-triazine) of the CS and its fragment. X-ray analysis clearly showed the presence of the guest as well as the π-π, CH-halogen, and CH-O interactions between the guest and the CS framework. However, some guests remained randomly diffused in the nanopores of CS. In addition, the detection limit was less than sub-pmol order based on the weight and density of CS determined by X-ray analysis. Spectroscopic data, such as UV-vis and NMR, also supported the encapsulation of the guest through the interaction between the guest and CS components. The results denote that the CS-LDI-MS method, which combines CS, X-ray analysis and LDI-MS, is effective for structure determination.

Switch-peptides: design and characterization of controllable super-amyloid-forming host-guest peptides as tools for identifying anti-amyloid agents.

PubMed

Camus, Marie-Stéphanie; Dos Santos, Sonia; Chandravarkar, Arunan; Mandal, Bhubaneswar; Schmid, Adrian W; Tuchscherer, Gabriele; Mutter, Manfred; Lashuel, Hilal A

2008-09-01

Several amyloid-forming proteins are characterized by the presence of hydrophobic and highly amyloidogenic core sequences that play critical roles in the initiation and progression of amyloid fibril formation. Therefore targeting these sequences represents a viable strategy for identifying candidate molecules that could interfere with amyloid formation and toxicity of the parent proteins. However, the highly amyloidogenic and insoluble nature of these sequences has hampered efforts to develop high-throughput fibrillization assays. Here we describe the design and characterization of host-guest switch peptides that can be used for in vitro mechanistic and screening studies that are aimed at discovering aggregation inhibitors that target highly amyloidogenic sequences. These model systems are based on a host-guest system where the amyloidogenic sequence (guest peptide) is flanked by two beta-sheet-promoting (Leu-Ser)(n) oligomers as host sequences. Two host-guest peptides were prepared by using the hydrophobic core of Abeta comprising residues 14-24 (HQKLVFFAEDV) as the guest peptide with switch elements inserted within (peptide 1) or at the N and C termini of the guest peptide (peptide 2). Both model peptides can be triggered to undergo rapid self-assembly and amyloid formation in a highly controllable manner and their fibrillization kinetics is tuneable by manipulating solution conditions (for example, peptide concentration and pH). The fibrillization of both peptides reproduces many features of the full-length Abeta peptides and can be inhibited by known inhibitors of Abeta fibril formation. Our results suggest that this approach can be extended to other amyloid proteins and should facilitate the discovery of small-molecule aggregation inhibitors and the development of more efficacious anti-amyloid agents to treat and/or reverse the pathogenesis of neurodegenerative and systemic amyloid diseases.

Increasing Sun Protection in Winter Outdoor Recreation

PubMed Central

Walkosz, Barbara J.; Buller, David B.; Andersen, Peter A.; Scott, Michael D.; Dignan, Mark B.; Cutter, Gary R.; Maloy, Julie A.

2009-01-01

Background Unprotected and excessive exposure to ultraviolet radiation (UVR) is the primary risk factor for skin cancer. Design A pair-matched, group-randomized, pre-test/post-test, quasi-experimental design, with ski resorts as the unit of randomization, tested the effectiveness of Go Sun Smart, a multi-channel skin cancer prevention program. Independent samples of guests were taken at baseline (2001) and follow-up (2002); data were analyzed in 2006. Setting and Participants A total of 6516 adult guests at 26 ski resorts in the western U.S. and Canada were recruited, consented, and interviewed on chairlifts. This study was nested within an occupational intervention for ski resort workers. Intervention Ski resorts were pair-matched and randomized to receive Go Sun Smart, which consisted of print, electronic, visual, and interpersonal skin cancer prevention messages. Main Outcome Measures Sun-protection behaviors, sunburning, recall of sun-protection messages, and the association of message exposure to sun protection. Results The difference in recall of all sun-protection messages, messages on signs and posters, and the Go Sun Smart logo was significant between the intervention and control resorts. Reported use of sun-protection practices was higher by guests at intervention ski areas using more (a higher dose of) Go Sun Smart materials. Intervention-group guests who recalled a sun-safety message were more likely to practice sun safety than intervention-group guests who did not recall a message and control-group guests. Conclusions While the mere implementation of Go Sun Smart did not produce sun-safety improvements, Go Sun Smart appeared to be effective for guests who encountered and remembered it. Many factors can work against message exposure. Signage seemed to produce the greatest increase in exposure to sun-safety messages. PMID:18471586

Learning from a dive show in an aquarium setting

NASA Astrophysics Data System (ADS)

Walsh, Lori M.

A study was conducted at an aquarium next to a theme park to understand information recalled from two versions of shows viewed at the largest display. The goal of this research was to determine if learning was enhanced by having a diver in water as the treatment group. This project focused on the knowledge recalled about shark and ray feeding adaptations, the information recalled about the mentioned conservation message about sustainable seafood and the potential of the two shows to make memorable experiences. During the project, 30 adult participants from each group were given a survey with five open-ended questions. Results suggest that the diver might distract from biological content information, or that the diver is such a novel element that it interferes with recall. While guests seemed to recall information about rays and sharks, the amount of information was not substantial. It appears that the diver does not affect content messaging but does impact whether guests attend to Seafood Watch messaging. The diver may have been so novel that the treatment group could not attend to the conservation message that was delivered, regardless of topic, or the control group recalled the message because the guests were not distracted by the diver or feeding. The absence of a diver seems to allow the guests to better attend to what is happening outside of the tank. While adding a diver increases photo opportunities and may bring guests to a show, the results seem to indicate that it does not significantly increase recall. The results of this study show that guests in a theme park setting can recall information from an educational program. Guests may not enter this hybrid aquarium with the intention of learning, but recall, one of the components in learning, does occur.

The SAMPL4 host-guest blind prediction challenge: an overview.

PubMed

Muddana, Hari S; Fenley, Andrew T; Mobley, David L; Gilson, Michael K

2014-04-01

Prospective validation of methods for computing binding affinities can help assess their predictive power and thus set reasonable expectations for their performance in drug design applications. Supramolecular host-guest systems are excellent model systems for testing such affinity prediction methods, because their small size and limited conformational flexibility, relative to proteins, allows higher throughput and better numerical convergence. The SAMPL4 prediction challenge therefore included a series of host-guest systems, based on two hosts, cucurbit[7]uril and octa-acid. Binding affinities in aqueous solution were measured experimentally for a total of 23 guest molecules. Participants submitted 35 sets of computational predictions for these host-guest systems, based on methods ranging from simple docking, to extensive free energy simulations, to quantum mechanical calculations. Over half of the predictions provided better correlations with experiment than two simple null models, but most methods underperformed the null models in terms of root mean squared error and linear regression slope. Interestingly, the overall performance across all SAMPL4 submissions was similar to that for the prior SAMPL3 host-guest challenge, although the experimentalists took steps to simplify the current challenge. While some methods performed fairly consistently across both hosts, no single approach emerged as consistent top performer, and the nonsystematic nature of the various submissions made it impossible to draw definitive conclusions regarding the best choices of energy models or sampling algorithms. Salt effects emerged as an issue in the calculation of absolute binding affinities of cucurbit[7]uril-guest systems, but were not expected to affect the relative affinities significantly. Useful directions for future rounds of the challenge might involve encouraging participants to carry out some calculations that replicate each others' studies, and to systematically explore parameter options.

Preparing for a Guest Clinician's Rehearsal with Your Choir: Inviting a Guest Director to Work with Your Choir Can Bring Fresh Perspectives and Reinforce Basic Concepts

ERIC Educational Resources Information Center

Lanier, Brian

2007-01-01

As choral directors across the country work to prepare their choirs for concerts, festivals, and contests, it is a common practice for them to invite a guest clinician to attend rehearsals for guidance and assistance. The rationale for this idea is logical and simple--two heads are better than one. However, the actual visit can be anything from a…

β-Cyclodextrin's orientation onto TiO2 and its paradoxical role in guest's photodegradation.

PubMed

Zhang, Xu; Yang, Zixin; Li, Xuankun; Deng, Nansheng; Qian, Shahua

2013-01-28

This work revealed that β-cyclodextrin was attached onto the surface of TiO(2) predominately by its secondary ring side, which caused paradoxical functions of β-cyclodextrin in the photodegradation of the four bisphenols. The equilibrium between the guest adsorbed through β-cyclodextrin onto TiO(2) and the one locked in β-CD in water could also change the role of β-cyclodextrin in the degradation of a certain guest.

Heterogeneous VM Replication: A New Approach to Intrusion Detection, Active Response and Recovery in Cloud Data Centers

DTIC Science & Technology

2015-08-17

from the same execution history, and cost-effective active response by proactively setting up standby VM replicas: migration from a compromised VM...the guest OSes system call code to be reused inside a “shadowed” portion of the context of the out-of- guest inspection program. Besides...by the rootkits in cloud environments. RootkitDet detects rootkits by identifying suspicious code region in the kernel space of guest OSes through

Neutral Guest Capture via Lewis Acid/Base Molecular Square Receptors. X-ray Crystal Structure of {Cyclobis[(cis-(dppp)Pt(4-ethynylpyridyl)(2))(cis- (PEt(3))(2)Pt)]Ag(2)}(+6)(phenazine)- ((-)OSO(2)CF(3))(6).

PubMed

Whiteford, Jeffery A.; Stang, Peter J.; Huang, Songping D.

1998-10-19

Interaction of {cyclobis[(cis-(dppp)Pt(4-ethynylpyridyl)(2))(cis-(L)M)]Ag(2)}(+6)((-)OSO(2)CF(3))(6), where M = Pt(II) or Pd(II) and L = dppp or 2PEt(3), with pyridine, pyrazine, phenazine, or 4,4'-dipyridyl ketone results in coordination Lewis acid/base host-guest assemblies via the "pi-tweezer effect" and mono or bis neutral guest coordination. All host-guest complexes are air stable microcrystalline solids with decomposition points greater than 170 degrees C. The homometallic Pt(II) receptors are more stable than the heteroaromatic Pt(II)-Pd(II) receptors toward heteratom-containing aromatic guests. The X-ray crystal structure of the host-guest complex {cyclobis[(cis-(dppp)Pt(4-ethynylpyridyl)(2))(cis-(PEt(3))(2)Pt)]Ag(2)}(+6)(phenazine)((-)OSO(2)CF(3))(6) is reported. The crystals with the empirical formula C(62)H(68)AgF(9)N(3)O(9)P(4)Pt(2)S(3) are triclinic P&onemacr; with a = 12.3919(8) Å, b = 17.160(1) Å, c = 18.932(1) Å, alpha = 90.892(1) degrees, beta = 97.127(1) degrees, gamma = 89.969(1) degrees, and Z = 2.

Guest Programmable Multistep Spin Crossover in a Porous 2-D Hofmann-Type Material.

PubMed

Murphy, Michael J; Zenere, Katrina A; Ragon, Florence; Southon, Peter D; Kepert, Cameron J; Neville, Suzanne M

2017-01-25

The spin crossover (SCO) phenomenon defines an elegant class of switchable materials that can show cooperative transitions when long-range elastic interactions are present. Such materials can show multistepped transitions, targeted both fundamentally and for expanded data storage applications, when antagonistic interactions (i.e., competing ferro- and antiferro-elastic interactions) drive concerted lattice distortions. To this end, a new SCO framework scaffold, [Fe II (bztrz) 2 (Pd II (CN) 4 )]·n(guest) (bztrz = (E)-1-phenyl-N-(1,2,4-triazol-4-yl)methanimine, 1·n(guest)), has been prepared that supports a variety of antagonistic solid state interactions alongside a distinct dual guest pore system. In this 2-D Hofmann-type material we find that inbuilt competition between ferro- and antiferro-elastic interactions provides a SCO behavior that is intrinsically frustrated. This frustration is harnessed by guest exchange to yield a very broad array of spin transition characters in the one framework lattice (one- (1·(H 2 O,EtOH)), two- (1·3H 2 O) and three-stepped (1·∼2H 2 O) transitions and SCO-deactivation (1)). This variety of behaviors illustrates that the degree of elastic frustration can be manipulated by molecular guests, which suggests that the structural features that contribute to multistep switching may be more subtle than previously anticipated.

Tunable Two-color Luminescence and Host-guest Energy Transfer of Fluorescent Chromophores Encapsulated in Metal-Organic Frameworks

NASA Astrophysics Data System (ADS)

Yan, Dongpeng; Tang, Yanqun; Lin, Heyang; Wang, Dan

2014-03-01

Co-assembly of chromophore guests with host matrices can afford materials which have photofunctionalities different from those of individual components. Compared with clay and zeolite materials, the use of metal-organic frameworks (MOFs) as a host structure for fabricating luminescent host-guest materials is still at an early stage. Herein, we report the incorporation of a laser dye, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), into stilbene-based and naphthalene-based MOF systems. The resulting materials exhibit blue/red two-color emission, and the intensity ratio of blue to red fluorescence varies in different planes within the MOF crystal as detected by 3D confocal fluorescence microscopy. The observed changes in ratiometric fluorescence suggest the occurrence of energy transfer from MOF host to DCM molecules, which can be further confirmed by periodic density functional theoretical (DFT) calculations. Moreover, selective changes in luminescence behavior are observed on treating the guest@MOF samples with volatile organic compounds (methanol, acetone and toluene), indicating that these host-guest systems have potential applications as fluorescence sensors. It can be expected that by rational selection of MOF hosts and guest chromophores with suitable emissive colors and energy levels, a wide variety of multi-color luminescent and energy-transfer systems can readily be prepared in a similar manner.

New Editors Appointed for Water Resources Research

NASA Astrophysics Data System (ADS)

2009-03-01

Praveen Kumar (University of Illinois at Urbana-Champaign), the newly appointed editor in chief of Water Resources Research (WRR), heads the new team of editors for the journal. The other editors are Tom Torgersen (University of Connecticut, Groton), who continues his editorship; Tissa Illangasekare (Colorado School of Mines, Golden); Graham Sander (Loughborough University, Loughborough, UK); and John Selker (Oregon State University, Corvallis). Hoshin Gupta (University of Arizona, Tucson) will join WRR at the end of 2009. The new editors will begin receiving submissions immediately. The incoming editorial board thanks outgoing editors Marc Parlange, Brian Berkowitz, Amilcare Porporato, and Scott Tyler, all of whom will assist during the transition.

Cucurbituril mediated single molecule detection and identification via recognition tunneling.

PubMed

Xiao, Bohuai; Liang, Feng; Liu, Simin; Im, JongOne; Li, Yunchuan; Liu, Jing; Zhang, Bintian; Zhou, Jianghao; He, Jin; Chang, Shuai

2018-06-08

Recognition tunneling (RT) is an emerging technique for investigating single molecules in a tunnel junction. We have previously demonstrated its capability of single molecule detection and identification, as well as probing the dynamics of intermolecular bonding at the single molecule level. Here by introducing cucurbituril as a new class of recognition molecule, we demonstrate a powerful platform for electronically investigating the host-guest chemistry at single molecule level. In this report, we first investigated the single molecule electrical properties of cucurbituril in a tunnel junction. Then we studied two model guest molecules, aminoferrocene and amantadine, which were encapsulated by cucurbituril. Small differences in conductance and lifetime can be recognized between the host-guest complexes with the inclusion of different guest molecules. By using a machine learning algorithm to classify the RT signals in a hyper dimensional space, the accuracy of guest molecule recognition can be significantly improved, suggesting the possibility of using cucurbituril molecule for single molecule identification. This work enables a new class of recognition molecule for RT technique and opens the door for detecting a vast variety of small molecules by electrical measurements.

Host-guest chemistry of dendrimer-drug complexes. 2. Effects of molecular properties of guests and surface functionalities of dendrimers.

PubMed

Hu, Jingjing; Cheng, Yiyun; Wu, Qinglin; Zhao, Libo; Xu, Tongwen

2009-08-06

The host-guest chemistry of dendrimer-drug complexes is investigated by NMR techniques, including (1)H NMR and 2D-NOESY studies. The effects of molecular properties of drug molecules (protonation ability and spatial steric hindrance of charged groups) and surface functionalities of dendrimers (positively charged amine groups and negatively charged carboxylate groups) on the host-guest interactions are discussed. Different interaction mechanisms between dendrimers and drug molecules are proposed on the basis of NMR results. Primary amine- and secondary amine-containing drugs preferentially bind to negatively charged dendrimers by strong electrostatic interactions, whereas tertiary amine and quaternary ammonium-containing drugs have weak binding ability with dendrimers due to relatively low protonation ability of the tertiary amine group and serious steric hindrance of the quaternary ammonium group. Positively charged drugs locate only on the surface of negatively charged dendrimers, whereas negatively charged drugs locate both on the surface and in the interior cavities of positively charged dendrimers. The host-guest chemistry of dendrimer-drug complexes is promising for the development of new drug delivery systems.

Organic Nanoflowers from a Wide Variety of Molecules Templated by a Hierarchical Supramolecular Scaffold.

PubMed

Negrón, Luis M; Díaz, Tanya L; Ortiz-Quiles, Edwin O; Dieppa-Matos, Diómedes; Madera-Soto, Bismark; Rivera, José M

2016-03-15

Nanoflowers (NFs) are flowered-shaped particles with overall sizes or features in the nanoscale. Beyond their pleasing aesthetics, NFs have found a number of applications ranging from catalysis, to sensing, to drug delivery. Compared to inorganic based NFs, their organic and hybrid counterparts are relatively underdeveloped mostly because of the lack of a reliable and versatile method for their construction. We report here a method for constructing NFs from a wide variety of biologically relevant molecules (guests), ranging from small molecules, like doxorubicin, to biomacromolecules, like various proteins and plasmid DNA. The method relies on the encapsulation of the guests within a hierarchically structured particle made from supramolecular G-quadruplexes. The size and overall flexibility of the guests dictate the broad morphological features of the resulting NFs, specifically, small and rigid guests favor the formation of NFs with spiky petals, while large and/or flexible guests promote NFs with wide petals. The results from experiments using confocal fluorescence microscopy, and scanning electron microscopy provides the basis for the proposed mechanism for the NF formation.

Testing a Theory-Based Health Communication Program: A Replication of Go Sun Smart in Outdoor Winter Recreation

PubMed Central

ANDERSEN, PETER A.; BULLER, DAVID B.; WALKOSZ, BARBARA J.; MALOY, JULIE; SCOTT, MICHAEL D.; CUTTER, GARY R.; DIGNAN, MARK B.

2010-01-01

The epidemic of preventable skin cancer in the United States creates an urgent need for health communication campaigns to improve sun protection. Go Sun Smart (GSS), a theory-driven multichannel health communication campaign showed positive effects on sun safety behaviors of employees and guests in a randomized trial at high-altitude ski areas. In this article we report findings from the North American GSS campaign for guests at ski areas that comprosed the original control-group resorts, replicating the results of the original guest intervention. Results showed that after GSS was deployed, guests at the original control group ski areas increased sun protection and reported greater recall of sun safety messages. Conversely, GSS had no effect on sunburning attitudes or self-efficacy beliefs. Like the original GSS guest intervention, the present study found that greater exposure to GSS messages was associated with greater use of sunscreen, sunscreen lip balm, and face covering, but not gloves or overall sun protection. There was no evidence that GSS decreased sunburning or attitudes and self-efficacy beliefs regarding sun safety. PMID:19466647

Self-Healing and Thermo-Responsive Dual-Crosslinked Alginate Hydrogels based on Supramolecular Inclusion Complexes

PubMed Central

Miao, Tianxin; Fenn, Spencer L.; Charron, Patrick N.; Oldinski, Rachael A.

2015-01-01

β-cyclodextrin (β-CD), with a lipophilic inner cavity and hydrophilic outer surface, interacts with a large variety of non-polar guest molecules to form non-covalent inclusion complexes. Conjugation of β-CD onto biomacromolecules can form physically-crosslinked hydrogel networks upon mixing with a guest molecule. Herein describes the development and characterization of self-healing, thermo-responsive hydrogels, based on host-guest inclusion complexes between alginate-graft-β-CD and Pluronic® F108 (poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)). The mechanics, flow characteristics, and thermal response were contingent on the polymer concentrations, and the host-guest molar ratio. Transient and reversible physical crosslinking between host and guest polymers governed self-assembly, allowing flow under shear stress, and facilitating complete recovery of the material properties within a few seconds of unloading. The mechanical properties of the dual-crosslinked, multi-stimuli responsive hydrogels were tuned as high as 30 kPa at body temperature, and are advantageous for biomedical applications such as drug delivery and cell transplantation. PMID:26509214

Energy-cascade organic photovoltaic devices incorporating a host-guest architecture.

PubMed

Menke, S Matthew; Holmes, Russell J

2015-02-04

In planar heterojunction organic photovoltaic devices (OPVs), broad spectral coverage can be realized by incorporating multiple molecular absorbers in an energy-cascade architecture. Here, this approach is combined with a host-guest donor layer architecture previously shown to optimize exciton transport for the fluorescent organic semiconductor boron subphthalocyanine chloride (SubPc) when diluted in an optically transparent host. In order to maximize the absorption efficiency, energy-cascade OPVs that utilize both photoactive host and guest donor materials are examined using the pairing of SubPc and boron subnaphthalocyanine chloride (SubNc), respectively. In a planar heterojunction architecture, excitons generated on the SubPc host rapidly energy transfer to the SubNc guest, where they may migrate toward the dissociating, donor-acceptor interface. Overall, the incorporation of a photoactive host leads to a 13% enhancement in the short-circuit current density and a 20% enhancement in the power conversion efficiency relative to an optimized host-guest OPV combining SubNc with a nonabsorbing host. This work underscores the potential for further design refinements in planar heterojunction OPVs and demonstrates progress toward the effective separation of functionality between constituent OPV materials.

Giant Negative Area Compressibility Tunable in a Soft Porous Framework Material.

PubMed

Cai, Weizhao; Gładysiak, Andrzej; Anioła, Michalina; Smith, Vincent J; Barbour, Leonard J; Katrusiak, Andrzej

2015-07-29

A soft porous material [Zn(L)2(OH)2]n·Guest (where L is 4-(1H-naphtho[2,3-d]imidazol-1-yl)benzoate, and Guest is water or methanol) exhibits the strongest ever observed negative area compressibility (NAC), an extremely rare property, as at hydrostatic pressure most materials shrink in all directions and few expand in one direction. This is the first NAC reported in metal-organic frameworks (MOFs), and its magnitude, clearly visible and by far the highest of all known materials, can be reversibly tuned by exchanging guests adsorbed from hydrostatic fluids. This counterintuitive strong NAC of [Zn(L)2(OH)2]n·Guest arises from the interplay of flexible [-Zn-O(H)-]n helices with layers of [-Zn-L-]4 quadrangular puckered rings comprising large channel voids. The compression of helices and flattening of puckered rings combine to give a giant piezo-mechanical response, applicable in ultrasensitive sensors and actuators. The extrinsic NAC response to different hydrostatic fluids is due to varied host-guest interactions affecting the mechanical strain within the range permitted by exceptionally high flexibility of the framework.

Tailoring the Adsorption and Reaction Chemistry of the Metal-Organic Frameworks UiO-66, UiO-66-NH2, and HKUST-1 via the Incorporation of Molecular Guests.

PubMed

Ploskonka, Ann M; DeCoste, Jared B

2017-06-28

Metal-organic frameworks (MOFs) are versatile materials highly regarded for their porous nature. Depending on the synthetic method, various guest molecules may remain in the pores or can be systematically loaded for various reasons. Herein, we present a study that explores the effect of guest molecules on the adsorption and reactivity of the MOF in both the gas phase and solution. The differences between guest molecule interactions and the subsequent effects on their activity are described for each system. Interestingly, different effects are observed and described in detail for each class of guest molecules studied. We determine that there is a strong effect of alcohols with the secondary building unit of UiO MOFs, while Lewis bases have an effect on the reactivity of the -NH 2 group in UiO-66-NH 2 and adsorption by the coordinatively unsaturated copper sites in HKUST-1. These effects must be considered when determining synthesis and activation methods of MOFs toward various applications.

7. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer June 1965 DETAIL, PAINTING ON FLOOR OF SECOND FLOOR - Swain-Mitchell House, 1 Vestal Street, Nantucket, Nantucket County, MA

Redox-responsive self-healing materials formed from host–guest polymers

PubMed Central

Nakahata, Masaki; Takashima, Yoshinori; Yamaguchi, Hiroyasu; Harada, Akira

2011-01-01

Expanding the useful lifespan of materials is becoming highly desirable, and self-healing and self-repairing materials may become valuable commodities. The formation of supramolecular materials through host–guest interactions is a powerful method to create non-conventional materials. Here we report the formation of supramolecular hydrogels and their redox-responsive and self-healing properties due to host–guest interactions. We employ cyclodextrin (CD) as a host molecule because it is environmentally benign and has diverse applications. A transparent supramolecular hydrogel quickly forms upon mixing poly(acrylic acid) (pAA) possessing β-CD as a host polymer with pAA possessing ferrocene as a guest polymer. Redox stimuli induce a sol−gel phase transition in the supramolecular hydrogel and can control self-healing properties such as re-adhesion between cut surfaces. PMID:22027591

EPR Studies of the Binding Properties, Guest Dynamics, and Inner-Space Dimensions of a Water-Soluble Resorcinarene Capsule.

PubMed

Ayhan, Mehmet Menaf; Casano, Gilles; Karoui, Hakim; Rockenbauer, Antal; Monnier, Valérie; Hardy, Micaël; Tordo, Paul; Bardelang, David; Ouari, Olivier

2015-11-09

Nitroxide free radicals have been used to study the inner space of one of Rebek's water-soluble capsules. EPR and (1) H NMR spectroscopy, ESI-MS, and DFT calculations showed a preference for the formation of 1:2 complexes. EPR titrations allowed us to determine binding constants (Ka ) in the order of 10(7)  M(-2) . EPR spectral-shape analysis provided information on the guest rotational dynamics within the capsule. The interplay between optimum hydrogen bonding upon capsule formation and steric strain for guest accommodation highlights some degree of flexibility for guest inclusion, particularly at the center of the capsule where the hydrogen bond seam can be barely distorted or slightly disturbed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Stimuli Responsive Systems Constructed Using Cucurbit[n]uril-Type Molecular Containers

PubMed Central

2015-01-01

Conspectus This Account focuses on stimuli responsive systems that function in aqueous solution using examples drawn from the work of the Isaacs group using cucurbit[n]uril (CB[n]) molecular containers as key recognition elements. Our entry into the area of stimuli responsive systems began with the preparation of glycoluril derived molecular clips that efficiently distinguish between self and nonself by H-bonds and π–π interactions even within complex mixtures and therefore undergo self-sorting. We concluded that the selectivity of a wide variety of H-bonded supramolecular assemblies was higher than previously appreciated and that self-sorting is not exceptional behavior. This lead us to examine self-sorting within the context of CB[n] host–guest chemistry in water. We discovered that CB[n] homologues (CB[7] and CB[8]) display remarkably high binding affinity (Ka up to 1017 M–1) and selectivity (ΔΔG) toward their guests, which renders CB[n]s prime components for the construction of stimuli responsive host–guest systems. The CB[7]·adamantaneammonium ion complex, which is particularly privileged (Ka = 4.2 × 1012 M–1), was introduced by us as a stimulus to trigger constitutional changes in multicomponent self-sorting systems. For example, we describe how the free energy associated with the formation of host–guest complexes of CB[n]-type receptors can drive conformational changes of included guests like triazene–arylene foldamers and cationic calix[4]arenes, as well as induced conformational changes (e.g., ammonium guest size dependent homotropic allostery, metal ion triggered folding, and heterochiral dimerization) of the hosts themselves. Many guests display large pKa shifts within their CB[n]–guest complexes, which we used to promote pH controlled guest swapping and thermal trans-to-cis isomerization of azobenzene derivatives. We also used the high affinity and selectivity of CB[7] toward its guests to outcompete an enzyme (bovine carbonic anhydrase) for a two-faced inhibitor, which allowed stimuli responsive regulation of enzymatic activity. These results prompted us to examine the use of CB[n]-type receptors in both in vitro and in vivo biological systems. We demonstrated that adamantaneammonium ion can be used to intracellularly sequester CB[7] from gold nanoparticles passivated with hexanediammonium ion·CB[7] complexes and thereby trigger cytotoxicity. CB[7] derivatives bearing a biotin targeting group enhance the cytotoxicity of encapsulated oxaliplatin toward L1210FR cells. Finally, acyclic CB[n]-type receptors function as solubilizing excipients for insoluble drugs for drug delivery purposes and as a broad spectrum reversal agent for the neuromuscular blocking agents rocuronium, vecuronium, and cis-atracurium in rats. The work highlights the great potential for integration of CB[n]-type receptors with biological systems. PMID:24785941

Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications.

PubMed

Hu, Jinming; Liu, Shiyong

2014-07-15

CONSPECTUS: All living organisms and soft matter are intrinsically responsive and adaptive to external stimuli. Inspired by this fact, tremendous effort aiming to emulate subtle responsive features exhibited by nature has spurred the invention of a diverse range of responsive polymeric materials. Conventional stimuli-responsive polymers are constructed via covalent bonds and can undergo reversible or irreversible changes in chemical structures, physicochemical properties, or both in response to a variety of external stimuli. They have been imparted with a variety of emerging applications including drug and gene delivery, optical sensing and imaging, diagnostics and therapies, smart coatings and textiles, and tissue engineering. On the other hand, in comparison with molecular chemistry held by covalent bonds, supramolecular chemistry built on weak and reversible noncovalent interactions has emerged as a powerful and versatile strategy for materials fabrication due to its facile accessibility, extraordinary reversibility and adaptivity, and potent applications in diverse fields. Typically involving more than one type of noncovalent interactions (e.g., hydrogen bonding, metal coordination, hydrophobic association, electrostatic interactions, van der Waals forces, and π-π stacking), host-guest recognition refers to the formation of supramolecular inclusion complexes between two or more entities connected together in a highly controlled and cooperative manner. The inherently reversible and adaptive nature of host-guest molecular recognition chemistry, stemming from multiple noncovalent interactions, has opened up a new platform to construct novel types of stimuli-responsive materials. The introduction of host-guest chemistry not only enriches the realm of responsive materials but also confers them with promising new applications. Most intriguingly, the integration of responsive polymer building blocks with host-guest recognition motifs will endow the former with further broadened responsiveness to external stimuli and accordingly more sophisticated functions. In this Account, we summarize recent progress in the field of responsive polymeric materials containing host-guest recognition motifs with selected examples and highlight their versatile functional applications, whereas small molecule-oriented host-guest supramolecular systems are excluded. We demonstrate how the introduction of host-guest chemistry into conventional polymer systems can modulate their responsive modes to external stimuli. Moreover, the responsive specificity and selectivity of polymeric systems can also be inherited from the host-guest recognition motifs, and these features provide extra advantages in terms of function integration. The following discussions are categorized in terms of design and functions, namely, host-guest chemistry toward the fabrication of responsive polymers and assemblies, optical sensing and imaging, drug and gene delivery, and self-healing materials. A concluding remark on future developments is also presented. We wish this prosperous field would incur more original and evolutionary ideas and benefit fundamental research and our daily life in a more convenient way.

Towards the fluorogenic detection of peroxide explosives through host-guest chemistry.

PubMed

Almenar, Estefanía; Costero, Ana M; Gaviña, Pablo; Gil, Salvador; Parra, Margarita

2018-04-01

Two dansyl-modified β-cyclodextrin derivatives ( 1 and 2 ) have been synthesized as host-guest sensory systems for the direct fluorescent detection of the peroxide explosives diacetone diperoxide (DADP) and triacetone triperoxide (TATP) in aqueous media. The sensing is based on the displacement of the dansyl moiety from the cavity of the cyclodextrin by the peroxide guest resulting in a decrease of the intensity of the fluorescence of the dye. Both systems showed similar fluorescent responses and were more sensitive towards TATP than DADP.

Insertion of Guest Molecules into a Mixed Ligand Metal-Organic Framework via Single-Crystal-to-Single Crystal Guest Exchange

DTIC Science & Technology

2014-07-01

powder x-ray diffraction (PXRD), thermogravimentric analysis (TGA), and Fourier transform infrared (FTIR). 15. SUBJECT TERMS Metal organic frame work...the inclusion by using a variety of analytical techniques, such as powder x-ray diffraction (PXRD), thermo-gravimetric analysis (TGA), Fourier...Characterizations Analysis of the MOF and the complexes with the MOF and the guest molecules was performed using an Agilent GC-MS (Model 6890N GC and Model 5973N

Vectorial Biochemistry

ERIC Educational Resources Information Center

Bowne, S. W., Jr.; Bowne, G. D.

1975-01-01

Describes a biochemical concept called Mitchell's chemiosmotic hypothesis, which proposes a system that catalyzes the hydrolysis of ATP to ADP and inorganic phosphate. The system is reversible and causes a translocation of protons across a physiological membrane. (MLH)

75 FR 33299 - Environmental Impacts Statements; Notice Of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

...-963-0182. EIS No. 20100215, Final EIS, USFS, CO, Hermosa Park/Mitchell Lakes Land Exchange Project.../2010 to 07/ 26/2010. Dated: June 8, 2010. Ken Mittelholtz, Deputy Director, NEPA Compliance Division...

Cone penetrometer comparison testing.

DOT National Transportation Integrated Search

2011-01-01

A total of 61 cone penetration tests were performed at 14 sites in the state of Wisconsin. Data : reinforced conclusions from practice in Minnesota and previously performed test programs : related to the Marquette Interchange and Mitchell interchange...

11. Historic American Buildings Survey W. N. Manning, Photographer, July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey W. N. Manning, Photographer, July 18, 1935 DOOR TREATMENT IN PARLOR, S. W. ROOM - Crowell-Cantey-Alexander House, State Road 165, Fort Mitchell, Russell County, AL

10. Historic American Buildings Survey W. N. Manning, Photographer, July ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey W. N. Manning, Photographer, July 18, 1935 VIEW IN HALL, TOWARD FRONT OF HOUSE - Crowell-Cantey-Alexander House, State Road 165, Fort Mitchell, Russell County, AL

High Tech Programmers in Low-Income Communities: Creating a Computer Culture in a Community Technology Center

NASA Astrophysics Data System (ADS)

Kafai, Yasmin B.; Peppler, Kylie A.; Chiu, Grace M.

For the last twenty years, issues of the digital divide have driven efforts around the world to address the lack of access to computers and the Internet, pertinent and language appropriate content, and technical skills in low-income communities (Schuler & Day, 2004a and b). The title of our paper makes reference to a milestone publication (Schon, Sanyal, & Mitchell, 1998) that showcased some of the early work and thinking in this area. Schon, Sanyal and Mitchell's book edition included an article outlining the Computer Clubhouse, a type of community technology center model, which was developed to create opportunities for youth in low-income communities to become creators and designers of technologies by (1998). The model has been very successful scaling up, with over 110 Computer Clubhouses now in existence worldwide.

Comparison of three ice cloud optical schemes in climate simulations with community atmospheric model version 5

NASA Astrophysics Data System (ADS)

Zhao, Wenjie; Peng, Yiran; Wang, Bin; Yi, Bingqi; Lin, Yanluan; Li, Jiangnan

2018-05-01

A newly implemented Baum-Yang scheme for simulating ice cloud optical properties is compared with existing schemes (Mitchell and Fu schemes) in a standalone radiative transfer model and in the global climate model (GCM) Community Atmospheric Model Version 5 (CAM5). This study systematically analyzes the effect of different ice cloud optical schemes on global radiation and climate by a series of simulations with a simplified standalone radiative transfer model, atmospheric GCM CAM5, and a comprehensive coupled climate model. Results from the standalone radiative model show that Baum-Yang scheme yields generally weaker effects of ice cloud on temperature profiles both in shortwave and longwave spectrum. CAM5 simulations indicate that Baum-Yang scheme in place of Mitchell/Fu scheme tends to cool the upper atmosphere and strengthen the thermodynamic instability in low- and mid-latitudes, which could intensify the Hadley circulation and dehydrate the subtropics. When CAM5 is coupled with a slab ocean model to include simplified air-sea interaction, reduced downward longwave flux to surface in Baum-Yang scheme mitigates ice-albedo feedback in the Arctic as well as water vapor and cloud feedbacks in low- and mid-latitudes, resulting in an overall temperature decrease by 3.0/1.4 °C globally compared with Mitchell/Fu schemes. Radiative effect and climate feedback of the three ice cloud optical schemes documented in this study can be referred for future improvements on ice cloud simulation in CAM5.

FRED user's manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shilling, J.

1984-02-01

FRED, the friendly editor, is a screen-based structured editor. This manual is intended to serve the needs of a wide range of users of the FRED text editor. Most users will find it sufficient to read the introductory material in section 2, supplemented with the full command set description in section 3. Advanced users may wish to change the keystroke sequences which invoke editor commands. Section 4 describes how to change key bindings and how to define command macros. Some users may need to modify a language description or create an entirely new language description for use with FRED. Sectionmore » 5 describes the format of the language descriptions used by the editor, and describes how to construct a language grammar. Section 6 describes known portability problems of the FRED editor and should concern only system installation personnel. The editor points out syntax errors in the file being edited and does automatic pretty printing.« less

EDT mode for JED -- An advanced Unix text editor

NASA Astrophysics Data System (ADS)

McIlwrath, B. K.; Page, C. G.

This note describes Starlink extended EDT emulation for the JED editor. It provides a Unix text editor which can utilise the advanced facilities of DEC VTn00, xterm and similar terminals. JED in this mode provides a reasonably good emulation of the VAX/VMS editor EDT in addition to many extra facilities.

Becoming an Online Editor: Perceived Roles and Responsibilities of Wikipedia Editors

ERIC Educational Resources Information Center

Littlejohn, Allison; Hood, Nina

2018-01-01

Introduction: We report on the experiences of a group of people as they become Wikipedia editors. We test Benkler's (2002) theory that commons-based production processes accelerate the creation of capital, questioning what knowledge production processes do people engage in as they become editors? The analysis positions the development of editing…

Emerging Perspectives on Editorial Ethics: An Interview with Chris Higgins

ERIC Educational Resources Information Center

Jackson, Liz

2017-01-01

Chris Higgins took on the roles of Editor of "Educational Theory," and Editor-in-Chief of the "Philosophy of Education Yearbook" published by the Philosophy of Education Society, in 2013, after having been an Associate Editor and Book Review Editor for "Educational Theory" for six years. Higgins worked closely with…

Authors and editors assort on gender and geography in high-rank ecological publications

PubMed Central

Belou, Rebecca M.

2018-01-01

Peer-reviewed publication volume and caliber are widely-recognized proxies for academic merit, and a strong publication record is essential for academic success and advancement. However, recent work suggests that publication productivity for particular author groups may also be determined in part by implicit biases lurking in the publication pipeline. Here, we explore patterns of gender, geography, and institutional rank among authors, editorial board members, and handling editors in high-impact ecological publications during 2015 and 2016. A higher proportion of lead authors had female first names (33.9%) than editorial board members (28.9%), and the proportion of female first names among handling editors was even lower (21.1%). Female editors disproportionately edited publications with female lead authors (40.3% of publications with female lead authors were handled by female editors, though female editors handled only 34.4% of all studied publications). Additionally, ecological authors and editors were overwhelmingly from countries in the G8, and high-ranking academic institutions accounted for a large portion of both the published work, and its editorship. Editors and lead authors with female names were typically affiliated with higher-ranking institutions than their male peers. This description of author and editor features provides a baseline for benchmarking future trends in the ecological publishing culture. PMID:29420647

Authors and editors assort on gender and geography in high-rank ecological publications.

PubMed

Manlove, Kezia R; Belou, Rebecca M

2018-01-01

Peer-reviewed publication volume and caliber are widely-recognized proxies for academic merit, and a strong publication record is essential for academic success and advancement. However, recent work suggests that publication productivity for particular author groups may also be determined in part by implicit biases lurking in the publication pipeline. Here, we explore patterns of gender, geography, and institutional rank among authors, editorial board members, and handling editors in high-impact ecological publications during 2015 and 2016. A higher proportion of lead authors had female first names (33.9%) than editorial board members (28.9%), and the proportion of female first names among handling editors was even lower (21.1%). Female editors disproportionately edited publications with female lead authors (40.3% of publications with female lead authors were handled by female editors, though female editors handled only 34.4% of all studied publications). Additionally, ecological authors and editors were overwhelmingly from countries in the G8, and high-ranking academic institutions accounted for a large portion of both the published work, and its editorship. Editors and lead authors with female names were typically affiliated with higher-ranking institutions than their male peers. This description of author and editor features provides a baseline for benchmarking future trends in the ecological publishing culture.

JSME: a free molecule editor in JavaScript.

PubMed

Bienfait, Bruno; Ertl, Peter

2013-01-01

A molecule editor, i.e. a program facilitating graphical input and interactive editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. Today, when a web browser has become the universal scientific user interface, a tool to edit molecules directly within the web browser is essential. One of the most popular tools for molecular structure input on the web is the JME applet. Since its release nearly 15 years ago, however the web environment has changed and Java applets are facing increasing implementation hurdles due to their maintenance and support requirements, as well as security issues. This prompted us to update the JME editor and port it to a modern Internet programming language - JavaScript. The actual molecule editing Java code of the JME editor was translated into JavaScript with help of the Google Web Toolkit compiler and a custom library that emulates a subset of the GUI features of the Java runtime environment. In this process, the editor was enhanced by additional functionalities including a substituent menu, copy/paste, drag and drop and undo/redo capabilities and an integrated help. In addition to desktop computers, the editor supports molecule editing on touch devices, including iPhone, iPad and Android phones and tablets. In analogy to JME the new editor is named JSME. This new molecule editor is compact, easy to use and easy to incorporate into web pages. A free molecule editor written in JavaScript was developed and is released under the terms of permissive BSD license. The editor is compatible with JME, has practically the same user interface as well as the web application programming interface. The JSME editor is available for download from the project web page http://peter-ertl.com/jsme/

Real-time and quantitative fluorescent live-cell imaging with quadruplex-specific red-edge probe (G4-REP).

PubMed

Yang, Sunny Y; Amor, Souheila; Laguerre, Aurélien; Wong, Judy M Y; Monchaud, David

2017-05-01

The development of quadruplex-directed molecular diagnostic and therapy rely on mechanistic insights gained at both cellular and tissue levels by fluorescence imaging. This technique is based on fluorescent reporters that label cellular DNA and RNA quadruplexes to spatiotemporally address their complex cell biology. The photophysical characteristics of quadruplex probes usually dictate the modality of cell imaging by governing the selection of the light source (lamp, LED, laser), the optical light filters and the detection modality. Here, we report the characterizations of prototype from a new generation of quadruplex dye termed G4-REP (for quadruplex-specific red-edge probe) that provides fluorescence responses regardless of the excitation wavelength and modality (owing to the versatility gained through the red-edge effect), thus allowing for diverse applications and most imaging facilities. This is demonstrated by cell images (and associated quantifications) collected through confocal and multiphoton microscopy as well as through real-time live-cell imaging system over extended period, monitoring both non-cancerous and cancerous human cell lines. Our results promote a new way of designing versatile, efficient and convenient quadruplex-reporting dyes for tracking these higher-order nucleic acid structures in living human cells. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

The two worlds of race revisited: a meditation on race in the age of Obama.

PubMed

Early, Gerald

2011-01-01

Nearly fifty years ago, the American Academy organized a conference and two issues of its journal "Daedalus" on the topic of "The Negro American." The project engaged top intellectuals and policy-makers around the conflicts and limitations of mid-1960s liberalism in dealing with race. Specifically, they grappled with the persistent question of how to integrate a forced-worker population that had been needed but that was socially undesirable once its original purpose no longer existed. Today, racism has been discredited as an idea and legally sanctioned segregation belongs to the past, yet the question the conference participants explored -- in essence, how to make the unwanted wanted -- still remains. Recent political developments and anticipated demographic shifts, however, have recast the terms of the debate. Gerald Early, guest editor for the present volume, uses Barack Obama's election to the presidency as a pretext for returning to the central question of "The Negro American" project and, in turn, asking how white liberalism will fare in the context of a growing minority population in the United States. Placing his observations alongside those made by John Hope Franklin in 1965, Early positions his essay, and this issue overall, as a meditation on how far we have come in America to reach "the age of Obama" and at the same time how far we have to go before we can overcome "the two worlds of race."

Risk mitigation strategies for viral contamination of biotechnology products: consideration of best practices.

PubMed

Rosenberg, Amy S; Cherney, Barry; Brorson, Kurt; Clouse, Kathleen; Kozlowski, Steven; Hughes, Patricia; Friedman, Rick

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Viral contamination of biotech product facilities is a potentially devastating manufacturing risk and, unfortunately, is more common than is generally reported or previously appreciated. Although viral contaminants of biotech products are thought to originate principally from biological raw materials, all potential process risks merit evaluation. Limitations to existing methods for virus detection are becoming evident as emerging viruses have contaminated facilities and disrupted supplies of critical products. New technologies, such as broad-based polymerase chain reaction screens for multiple virus types, are increasingly becoming available to detect adventitious viral contamination and thus, mitigate risks to biotech products and processes. Further, the industry embrace of quality risk management that promotes improvements in testing stratagems, enhanced viral inactivation methods for raw materials, implementation and standardization of robust viral clearance procedures, and efforts to learn from both epidemiologic screening of raw material sources and from the experience of other manufacturers with regard to this problem will serve to enhance the safety of biotech products available to patients. Based on this evolving landscape, we propose a set of principles for manufacturers of biotech products: Pillars of Risk Mitigation for Viral Contamination of Biotech Products.

Backbone modified TBA analogues endowed with antiproliferative activity.

PubMed

Esposito, Veronica; Russo, Annapina; Amato, Teresa; Varra, Michela; Vellecco, Valentina; Bucci, Mariarosaria; Russo, Giulia; Virgilio, Antonella; Galeone, Aldo

2017-05-01

The thrombin binding aptamer (TBA) is endowed with antiproliferative properties but its potential development is counteracted by the concomitant anticoagulant activity. Five oligonucleotides (ODNs) based on TBA sequence (GGTTGGTGTGGTTGG) and containing l-residues or both l-residues and inversion of polarity sites have been investigated by NMR and CD techniques for their ability to form G-quadruplex structures. Furthermore, their anticoagulant (PT assay) and antiproliferative properties (MTT assay), and their resistance in fetal bovine serum have been tested. CD and NMR data suggest that the investigated ODNs are able to form right- and left-handed G-quadruplex structures. All ODNs do not retain the anticoagulant activity characteristic of TBA but are endowed with a significant antiproliferative activity against two cancerous cell lines. Their resistance in biological environment after six days is variable, depending on the ODN. A comparison between results and literature data suggests that the antiproliferative activity of the TBA analogues investigated could depends on two factors: a) biological pathways and targets different from those already identified or proposed for other antiproliferative G-quadruplex aptamers, and b) the contribution of the guanine-based degradation products. Modified TBA analogues containing l-residues and inversion of polarity sites lose the anticoagulant activity but gain antiproliferative properties against two cancer cell lines. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

Authorship issues

PubMed Central

Bavdekar, Sandeep B.

2012-01-01

Authorship is a highly sought attribute, as it is associated with recognition for creativity. In addition, it is associated with multiple benefits such as peer recognition, better evaluation and financial gains. These possibilities spur scientists to author articles, but some take recourse to unethical practice of honorary authorships. Another unethical practice is that of ghostwriting. It is a phenomenon wherein individuals who write the articles are not named as authors and are not even acknowledged to be associated with the manuscript. Reputed and renowned scientists, who have not participated in the conduct of the study or in the manuscript preparation, are enrolled by the industry to allow their names to be mentioned as authors. This phenomenon is harmful not only because it suppresses the contribution of ghost-authors but also because the guest “authors” bestow underserved credibility upon an “industry-written” paper. The readers have no way of knowing the bias that may have crept in. The journal editors, institution, and government agencies need to come together to ensure that these malpractices are curbed by employing various measures such as creating awareness amongst authors, academicians, and administrators; enunciating and implementing policies to dissuade unethical behavior, protecting whistle-blowers, and providing punishments to those indulging in malpractices. All of us should remember that if unchecked, these deviant behaviors have the potential to compromise the credibility of scientific research and scientific publications. PMID:22345922

Notes towards a 'social aesthetic': Guest editors' introduction to the special section.

PubMed

Olcese, Cristiana; Savage, Mike

2015-12-01

There is an emerging 'aesthetic turn' within sociology which currently lacks clear focus. This paper reviews the different issues feeding into this interest and contributes to its development. Previous renderings of this relationship have set the aesthetic up against sociology, as an emphasis which 'troubles' conventional understandings of sociality and offers no ready way of reconciling the aesthetic with the social. Reflecting on the contributions of recent social theorists, from figures including Bourdieu, Born, Rancière, Deleuze, and Martin, we argue instead for the value of a social aesthetic which critiques instrumentalist and reductive understandings of the social itself. In explicating what form this might take, the latter parts of the paper take issue with classical modernist conceptions of the aesthetic which continue to dominate popular and sociological understandings of the aesthetic, and uses the motif of 'walking' to show how the aesthetic can be rendered in terms of 'the mundane search' and how this search spans everyday experience and cultural re-production. We offer a provisional definition of social aesthetics as the embedded and embodied process of meaning making which, by acknowledging the physical/corporeal boundaries and qualities of the inhabited world, also allows imagination to travel across other spaces and times. It is hoped that this approach can be a useful platform for further inquiry. © London School of Economics and Political Science 2015.

Rewiring protein synthesis: From natural to synthetic amino acids.

PubMed

Fan, Yongqiang; Evans, Christopher R; Ling, Jiqiang

2017-11-01

The protein synthesis machinery uses 22 natural amino acids as building blocks that faithfully decode the genetic information. Such fidelity is controlled at multiple steps and can be compromised in nature and in the laboratory to rewire protein synthesis with natural and synthetic amino acids. This review summarizes the major quality control mechanisms during protein synthesis, including aminoacyl-tRNA synthetases, elongation factors, and the ribosome. We will discuss evolution and engineering of such components that allow incorporation of natural and synthetic amino acids at positions that deviate from the standard genetic code. The protein synthesis machinery is highly selective, yet not fixed, for the correct amino acids that match the mRNA codons. Ambiguous translation of a codon with multiple amino acids or complete reassignment of a codon with a synthetic amino acid diversifies the proteome. Expanding the genetic code with synthetic amino acids through rewiring protein synthesis has broad applications in synthetic biology and chemical biology. Biochemical, structural, and genetic studies of the translational quality control mechanisms are not only crucial to understand the physiological role of translational fidelity and evolution of the genetic code, but also enable us to better design biological parts to expand the proteomes of synthetic organisms. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

PubMed

Jiang, Bowen; Yu, Hua; Zhang, Yongrong; Feng, Hanping; Hoag, Stephen W

2017-12-01

There are many important diseases whose treatment could be improved by delivering a therapeutic protein to the colon, for example, Clostridium difficile infection, ulcerative colitis and Crohn's Disease. The goal of this project was to investigate the feasibility of colonic delivery of proteins using multiparticulate beads. In this work, bovine serum albumin (BSA) was adopted as a model protein. BSA was spray layered onto beads, followed by coating of an enteric polymer EUDRAGIT® FS 30 D to develop a colonic delivery system. The secondary and tertiary structure change and aggregation of BSA during spray layering process was examined. The BSA layered beads were then challenged in an accelerated stability study using International Council for Harmonization (ICH) conditions. The in vitro release of BSA from enteric coated beads was examined using United States Pharmacopeia (USP) dissolution apparatus 1. No significant changes in the secondary and tertiary structure or aggregation profile of BSA were observed after the spray layering process. Degradation of BSA to different extents was detected after storing at 25°C and 40°C for 38 days. Enteric coated BSA beads were intact in acidic media while released BSA in pH 7.4 phosphate buffer. We showed the feasibility of delivering proteins to colon in vitro using multiparticulate system.

The Design of Molecular Hosts, Guests, and Their Complexes.

ERIC Educational Resources Information Center

Cram, Donald J.

1988-01-01

Describes the origins, definitions, tools, and principles of host-guest chemistry. Gives examples of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell. (Author/RT)

Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties.

PubMed

Tomaselli, Simona; Ramirez, Diego Omar Sanchez; Carletto, Riccardo Andrea; Varesano, Alessio; Vineis, Claudia; Zanzoni, Serena; Molinari, Henriette; Ragona, Laura

2017-04-01

Electrospinning is here used for the first time to prepare nanofibers including a host/guest complex in a keratin/poly(ethylene oxide) matrix. The host is a lipid binding protein and the guest is an insoluble bactericidal molecule, irgasan, bound within the protein internal cavity. The obtained nanofibers, characterized by scanning electron microscopy, exhibit excellent antibacterial activity toward Gram positive and negative bacteria, even with a moderate protein/irgasan cargo. Solution NMR studies, employed to provide molecular information on the cargo system, points to a micromolar affinity, compatible with both the electrospinning process and slow guest release. The versatility of the carrier protein, capable of interacting with a variety of druggable hydrophobic molecules, is exploitable for the development of innovative biomedical devices, whose properties can be tuned by the selected guest. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

PubMed Central

Hasan, Samer; Ali, Hussein Al; Al-Qubaisi, Mothanna; Hussein, Mohd Zobir; Ismail, Maznah; Zainal, Zulkarnain; Hakim, Muhammad Nazrul

2012-01-01

A controlled-release formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite “CETN,” had a basal spacing of 33.9 Å, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The release study showed that about 96% of the guest could be released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC50 for CETN and ZLH are 617 and 670 μg/mL, respectively. PMID:22848164

Transforming MOFs for energy applications using the guest@MOF concept

DOE PAGES

Ullman, Andrew M.; Brown, Jonathan W.; Foster, Michael E.; ...

2016-07-11

As the world transitions from fossil fuels to clean energy sources in the coming decades, many technological challenges will require chemists and material scientists to develop new materials for applications related to energy conversion, storage, and efficiency. Because of their unprecedented adaptability, metal–organic frameworks (MOFs) will factor strongly in this portfolio. By utilizing the broad synthetic toolkit provided by the fields of organic and inorganic chemistry, MOF pores can be customized to suit a particular application. Of particular importance is the ability to tune the strength of the interaction between the MOF pores and guest molecules. By cleverly controlling thesemore » MOF–guest interactions, the chemist may impart new function into the Guest@MOF materials otherwise lacking in vacant MOF. Herein, we highlight the concept of the Guest@MOF as it relates to our efforts to develop these materials for energy-related applicatons. Additionally, our work in the areas of H 2 and noble gas storage, hydrogenolysis of biomass, light-harvesting, and conductive materials will be discussed. Of relevance to light-harvesting applications, we report for the first time a postsynthetic modification strategy for increasing the loading of a light-sensitive electron-donor molecule in the pores of a functionalized MIL-101 structure. Through the demonstrated versatility of these approaches, we show that, by treating guest molecules as integral design elements for new MOF constructs, MOF science can have a significant impact on the advancement of clean energy technologies.« less

Transforming MOFs for Energy Applications Using the Guest@MOF Concept.

PubMed

Ullman, Andrew M; Brown, Jonathan W; Foster, Michael E; Léonard, François; Leong, Kirsty; Stavila, Vitalie; Allendorf, Mark D

2016-08-01

As the world transitions from fossil fuels to clean energy sources in the coming decades, many technological challenges will require chemists and material scientists to develop new materials for applications related to energy conversion, storage, and efficiency. Because of their unprecedented adaptability, metal-organic frameworks (MOFs) will factor strongly in this portfolio. By utilizing the broad synthetic toolkit provided by the fields of organic and inorganic chemistry, MOF pores can be customized to suit a particular application. Of particular importance is the ability to tune the strength of the interaction between the MOF pores and guest molecules. By cleverly controlling these MOF-guest interactions, the chemist may impart new function into the Guest@MOF materials otherwise lacking in vacant MOF. Herein, we highlight the concept of the Guest@MOF as it relates to our efforts to develop these materials for energy-related applicatons. Our work in the areas of H2 and noble gas storage, hydrogenolysis of biomass, light-harvesting, and conductive materials will be discussed. Of relevance to light-harvesting applications, we report for the first time a postsynthetic modification strategy for increasing the loading of a light-sensitive electron-donor molecule in the pores of a functionalized MIL-101 structure. Through the demonstrated versatility of these approaches, we show that, by treating guest molecules as integral design elements for new MOF constructs, MOF science can have a significant impact on the advancement of clean energy technologies.

SCIL Executive Summaries.

ERIC Educational Resources Information Center

Samuels, Alan R.; And Others

1987-01-01

These five papers by speakers at the Small Computers in Libraries 1987 conference include: "Acquiring and Using Shareware in Building Small Scale Automated Information systems" (Samuels); "A Software Lending Collection" (Talab); "Providing Subject Access to Microcomputer Software" (Mitchell); "Interfacing Vendor…

77 FR 52135 - Advisory Committee on Homeless Veterans, Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... an on-going assessment of the effectiveness of the policies, organizational structures, and services... patient privacy to conduct a site visit at the Donald J. Mitchell VA Outpatient Clinic, Griffiss Business...

Heat-Related Illnesses

MedlinePlus

... Share this! EmergencyCareForYou » Emergency 101 » Heat-Related Illnesses Heat-Related Illnesses Dr. Glenn Mitchell , Emergency physician at ... about heat cramps and heat stroke and exhaustion. Heat Cramps Symptoms include muscle spasms, usually in the ...

78 FR 24353 - Provisions for Fees Related to Hazardous Materials Endorsements and Transportation Worker...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... Mitchell, Office of Intelligence and Analysis (OIA), TSA-10, Transportation Security Administration, 601... Management System (FDMS) Web page at http://www.regulations.gov ; (2) Accessing the Government Printing...

Preparing Students To Work on Newspaper Copy Desks: Are Educators Meeting Editors' Expectations?

ERIC Educational Resources Information Center

Auman, Ann E.; Cook, Betsy B.

A study surveyed two groups in the fall of 1994, journalism educators and newspaper editors. Educators completed a survey regarding the course content and skill areas emphasized in beginning level copy editing courses, while editors were asked to respond to questions regarding the skills they expect entry-level copy editors to have. Respondents…

MRAPs, Irregular Warfare, and Pentagon Reform

DTIC Science & Technology

2009-06-01

U P R E S S S TA F F COLONEL DAVID H. GURNEY, USMC (RET.) Director DR. JEFFREY D. SMOTHERMAN Executive Editor GEORGE C. MAERZ Supervisory Editor...LISA M. YAMBRICK Writer-Editor CALVIN B. KELLEY Writer-Editor MARTIN J. PETERS Production Supervisor TARA J. PAREKH Visual Design Editor O T H E R T I T ...L E S I N T H E S E R I E S Choosing War: The Decision to Invade Iraq and Its Aftermath Occasional Paper 5, April 2008 China’s Global Activism

Web-Based Media Contents Editor for UCC Websites

NASA Astrophysics Data System (ADS)

Kim, Seoksoo

The purpose of this research is to "design web-based media contents editor for establishing UCC(User Created Contents)-based websites." The web-based editor features user-oriented interfaces and increased convenience, significantly different from previous off-line editors. It allows users to edit media contents online and can be effectively used for online promotion activities of enterprises and organizations. In addition to development of the editor, the research aims to support the entry of enterprises and public agencies to the online market by combining the technology with various UCC items.

Circularly Polarized Luminescence from Inorganic Materials: Encapsulating Guest Lanthanide Oxides in Chiral Silica Hosts.

PubMed

Sugimoto, Masumi; Liu, Xin-Ling; Tsunega, Seiji; Nakajima, Erika; Abe, Shunsuke; Nakashima, Takuya; Kawai, Tsuyoshi; Jin, Ren-Hua

2018-05-02

Recently, circularly polarized luminescence (CPL)-active systems have become a very hot and interesting subject in chirality- and optics-related areas. The CPL-active systems are usually available by two approaches: covalently combining a luminescent centre to chiral motif or associating the guest of luminescent probe to a chiral host. However, all the chiral components in CPL materials were organic, although the luminescent components were alternatively organics or inorganics. Herein, the first totally inorganic CPL-active system by "luminescent guest-chiral host" strategy is proposed. Luminescent sub-10 nm lanthanide oxides (Eu 2 O 3 or Tb 2 O 3 ) nanoparticles (guests) were encapsulated into chiral non-helical SiO 2 nanofibres (host) through calcination of chiral SiO 2 hybrid nanofibres, trapping Eu 3+ (or Tb 3+ ). These lanthanide oxides display circular dichroism (CD) optical activity in the ultraviolet wavelength and CPL signals around at 615 nm for Eu 3+ and 545 nm for Tb 3+ . This work has implications for inorganic-based CPL-active systems by incorporation of various luminescent guests within chiral inorganic hosts. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nonlinear optical moiety-doped polymers with improved optical properties for photonic devices

NASA Astrophysics Data System (ADS)

Lee, Myung-Hyun; Kim, Hwan K.; Kim, Hye-Young; Lee, Hyuek J.; Kang, K. H.; Won, Yong Hyub; Jeon, Eunsuk S.; Wu, Jeong W.

1994-05-01

An electro-optic polymer guest-host system has been constructed and demonstrated. The polymer host is a polyimide (PIQ2200) and the guest chromophores are dimethyl (or diethyl) amino alkyl sulfone stilbenes. The alkylated-NLO moieties as guest chromophores have been modified, yielding new alkylated-NLO moieties. The higher content of alkylated-NLO moieties, compared to unmodified NLO moieties, was doped into a polyimide host system due to the improved solubility of new alkylated-NLO moieties. To the 40 wt%, the new alkylated- NLO moiety has been completely dissolved in the preliminary experiment, leading to the increase of refractive index by 0.0016. These polyimide-based guest-host systems exhibited a significant improvement in the thermal stability at high temperatures exceeding 250 degree(s)C. The electro-optic coefficient reported in the present study is 13 pm/V for the 40 wt% DASS-6- doped polymer system poled at the 135 V/micrometers . However, further increase up to 25 pm/V may easily be achieved by increasing the amount of guest moieties and/or the intensity of the poling field. This work presents new materials for photonic switching devices with low operating voltage.

Increasing spin crossover cooperativity in 2D Hofmann-type materials with guest molecule removal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zenere, Katrina A.; Duyker, Samuel G.; Trzop, Elzbieta

Ambient temperature spin crossover with wide hysteresis has been achieved in 2D Hofmann-type materials, where removal of guest molecules optimises ligand–ligand interactions, resulting in increased cooperativity.

Increasing spin crossover cooperativity in 2D Hofmann-type materials with guest molecule removal

DOE PAGES

Zenere, Katrina A.; Duyker, Samuel G.; Trzop, Elzbieta; ...

2018-01-01

Ambient temperature spin crossover with wide hysteresis has been achieved in 2D Hofmann-type materials, where removal of guest molecules optimises ligand–ligand interactions, resulting in increased cooperativity.

Towards the fluorogenic detection of peroxide explosives through host–guest chemistry

PubMed Central

Almenar, Estefanía; Costero, Ana M.; Gil, Salvador; Parra, Margarita

2018-01-01

Two dansyl-modified β-cyclodextrin derivatives (1 and 2) have been synthesized as host–guest sensory systems for the direct fluorescent detection of the peroxide explosives diacetone diperoxide (DADP) and triacetone triperoxide (TATP) in aqueous media. The sensing is based on the displacement of the dansyl moiety from the cavity of the cyclodextrin by the peroxide guest resulting in a decrease of the intensity of the fluorescence of the dye. Both systems showed similar fluorescent responses and were more sensitive towards TATP than DADP. PMID:29765646

Specification Improvement Through Analysis of Proof Structure (SITAPS): High Assurance Software Development

DTIC Science & Technology

2016-02-01

from the tools being used. For example, while Coq proves properties it does not dump an explanation of the proofs in any currently supported form. The...Distribution Unlimited 5 Hotel room locks and card keys use a simple protocol to manage the transition of rooms from one guest to the next. The lock...retains that guest key’s code. A new guest checks in and gets a card with a new current code, and the previous code set to the previous guest’s current

Tunable electrical conductivity in metal-organic framework thin film devices

DOEpatents

Talin, Albert Alec; Allendorf, Mark D.; Stavila, Vitalie; Leonard, Francois

2016-08-30

A composition including a porous metal organic framework (MOF) including an open metal site and a guest species capable of charge transfer that can coordinate with the open metal site, wherein the composition is electrically conductive. A method including infiltrating a porous metal organic framework (MOF) including an open metal site with a guest species that is capable of charge transfer; and coordinating the guest species to the open metal site to form a composition including an electrical conductivity greater than an electrical conductivity of the MOF.

Tunable electrical conductivity in metal-organic framework thin film devices

DOEpatents

Talin, Albert Alec; Allendorf, Mark D.; Stavila, Vitalie; Leonard, Francois

2016-05-24

A composition including a porous metal organic framework (MOF) including an open metal site and a guest species capable of charge transfer that can coordinate with the open metal site, wherein the composition is electrically conductive. A method including infiltrating a porous metal organic framework (MOF) including an open metal site with a guest species that is capable of charge transfer; and coordinating the guest species to the open metal site to form a composition including an electrical conductivity greater than an electrical conductivity of the MOF.

A Two-Stream Plasma Electron Microwave Source for High-Power Millimeter Wave Generation. Phase 1

DTIC Science & Technology

1989-03-29

MIT Press, Cambridge, MA, 1963). these findings that strong amplification is possible for repre- ’See, for example, G. E. Guest and D. J. Sigmar , Nucl...stringency of the stability criteria for electrostatic and whistler modes, as fl(z=O, 6, t=O) = -i/2u,(e/m) discussed by Guest and Sigmar [22], and...therein. Function. Academic Press, New York (1961). 1221 GUEST, G.E., SIGMAR , D.J., Nuci. Fusion It1(1971) [271 ABRAMOWITZ, M., STEGUN. I.A. (Eds

29 CFR 793.8 - “News editor.”

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

29 CFR 793.8 - “News editor.”

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

29 CFR 793.8 - “News editor.”

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

29 CFR 793.8 - “News editor.”

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

29 CFR 793.8 - “News editor.”

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective

ERIC Educational Resources Information Center

Xun, Gong

2007-01-01

Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

Cyclic Bis-porphyrin-Based Flexible Molecular Containers: Controlling Guest Arrangements and Supramolecular Catalysis by Tuning Cavity Size.

PubMed

Mondal, Pritam; Sarkar, Sabyasachi; Rath, Sankar Prasad

2017-05-23

Three cyclic zinc(II) bis-porphyrins (CB) with highly flexible linkers are employed as artificial molecular containers that efficiently encapsulate/coordinate various aromatic aldehydes within their cavities. Interestingly, the arrangements of guests and their reactivity inside the molecular clefts are significantly influenced by the cavity size of the cyclic containers. In the presence of polycyclic aromatic aldehydes, such as 3-formylperylene, as a guest, the cyclic bis-porphyrin host with a smaller cavity (CB1) forms a 1:1 sandwich complex. Upon slightly increasing the spacer length and thereby the cavity size, the cyclic host (CB2) encapsulates two molecules of 3-formylperylene that are also stacked together due to strong π-π interactions between them and CH-π interactions with the porphyrin rings. However, in the cyclic host (CB3) with an even larger cavity, two metal centers of the bis-porphyrin axially coordinate two molecules of 3-formylperylene within its cavity. Different arrangements of guest inside the cyclic bis-porphyrin hosts are investigated by using UV/Vis, ESI-MS, and 1 H NMR spectroscopy, along with X-ray structure determination of the host-guest complexes. Moreover, strong binding of guests within the cyclic bis-porphyrin hosts support the robust nature of the host-guest assemblies in solution. Such preferential binding of the bis-porphyrinic cavity towards aromatic aldehydes through encapsulation/coordination has been employed successfully to catalyze the Knoevenagel condensation of a series of polycyclic aldehydes with active methylene compounds (such as Meldrum's acid and 1, 3-dimethylbarbituric acid) under ambient conditions. Interestingly, the yields of the condensed products significantly increase upon increasing spacer lengths of the cyclic bis-porphyrins because more substrates can then be encapsulated within the cavity. Such controllable cavity size of the cyclic containers has profound implications for constructing highly functional and modular enzyme mimics. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

EDITORIAL: Special section: Selected papers from the Second European Workshop on Monte Carlo Treatment Planning (MCTP2009) Special section: Selected papers from the Second European Workshop on Monte Carlo Treatment Planning (MCTP2009)

NASA Astrophysics Data System (ADS)

Spezi, Emiliano

2010-08-01

Sixty years after the paper 'The Monte Carlo method' by N Metropolis and S Ulam in The Journal of the American Statistical Association (Metropolis and Ulam 1949), use of the most accurate algorithm for computer modelling of radiotherapy linear accelerators, radiation detectors and three dimensional patient dose was discussed in Wales (UK). The Second European Workshop on Monte Carlo Treatment Planning (MCTP2009) was held at the National Museum of Wales in Cardiff. The event, organized by Velindre NHS Trust, Cardiff University and Cancer Research Wales, lasted two and a half days, during which leading experts and contributing authors presented and discussed the latest advances in the field of Monte Carlo treatment planning (MCTP). MCTP2009 was highly successful, judging from the number of participants which was in excess of 140. Of the attendees, 24% came from the UK, 46% from the rest of Europe, 12% from North America and 18% from the rest of the World. Fifty-three oral presentations and 24 posters were delivered in a total of 12 scientific sessions. MCTP2009 follows the success of previous similar initiatives (Verhaegen and Seuntjens 2005, Reynaert 2007, Verhaegen and Seuntjens 2008), and confirms the high level of interest in Monte Carlo technology for radiotherapy treatment planning. The 13 articles selected for this special section (following Physics in Medicine and Biology's usual rigorous peer-review procedure) give a good picture of the high quality of the work presented at MCTP2009. The book of abstracts can be downloaded from http://www.mctp2009.org. I wish to thank the IOP Medical Physics and Computational Physics Groups for their financial support, Elekta Ltd and Dosisoft for sponsoring MCTP2009, and leading manufacturers such as BrainLab, Nucletron and Varian for showcasing their latest MC-based radiotherapy solutions during a dedicated technical session. I am also very grateful to the eight invited speakers who kindly accepted to give keynote presentations which contributed significantly to raising the quality of the event and capturing the interest of the medical physics community. I also wish to thank all those who contributed to the success of MCTP2009: the members of the local Organizing Committee and the Workshop Management Team who managed the event very efficiently, the members of the European Working Group in Monte Carlo Treatment Planning (EWG-MCTP) who acted as Guest Associate Editors for the MCTP2009 abstracts reviewing process, and all the authors who generated new, high quality work. Finally, I hope that you find the contents of this special section enjoyable and informative. Emiliano Spezi Chairman of MCTP2009 Organizing Committee and Guest Editor References Metropolis N and Ulam S 1949 The Monte Carlo method J. Amer. Stat. Assoc. 44 335-41 Reynaert N 2007 First European Workshop on Monte Carlo Treatment Planning J. Phys.: Conf. Ser. 74 011001 Verhaegen F and Seuntjens J 2005 International Workshop on Current Topics in Monte Carlo Treatment Planning Phys. Med. Biol. 50 Verhaegen F and Seuntjens J 2008 International Workshop on Monte Carlo Techniques in Radiotherapy Delivery and Verification J. Phys.: Conf. Ser. 102 011001

39. Photocopy of photograph (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Photocopy of photograph (original in possession of WACC), photographer unknown, c.1930's GUEST DINING ROOM WITH TABLE LAID FOR GUESTS - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

Prospects for Prevention and Amelioration of Mental Retardation: A Guest Editorial

ERIC Educational Resources Information Center

Clarke, A. D. B.; Clarke, Ann M.

1977-01-01

In a guest editorial, the view of the President's Committee on Mental Retardation (1972), that the incidence of mental retardation can be decreased by 50 percent by the year 2000, is critically examined. (BB)

50th Anniversary Gala

NASA Image and Video Library

2011-10-15

NASA Administrator Charles Bolden (at podium) speaks to guests gathered for Stennis Space Center's 50th Anniversary Gala event Oct. 15. The event was attended by more than 300 NASA employees and guests and featured various program presentations and speakers.

Bertram Brockhouse, the Triple-axis Spectrometer, and Neutron Spectroscopy

Science.gov Websites

foreign guest scientist in the Reactor Department at Brookhaven National Laboratory [BNL]. During this and light and heavy water ... .'1 Brockhouse was again a foreign guest scientist at BNL in 1970. He

Encapsulation of a rhodamine dye within a bile acid binding protein: toward water processable functional bio host-guest materials.

PubMed

Tomaselli, Simona; Giovanella, Umberto; Pagano, Katiuscia; Leone, Giuseppe; Zanzoni, Serena; Assfalg, Michael; Meinardi, Francesco; Molinari, Henriette; Botta, Chiara; Ragona, Laura

2013-10-14

New strategies are requested for the preparation of bioinspired host-guest complexes to be employed in technologically relevant applications, as sensors and optoelectronic devices. We report here a new approach employing a single monomeric protein as host for the strongly fluorescent rhodamine dye. The selected protein, belonging to the intracellular lipid binding protein family, fully encapsulates one rhodamine molecule inside its cavity forming a host-guest complex stabilized by H and π-hydrogen bonds, a salt bridge, and favorable hydrophobic contacts, as revealed by the NMR derived structural model. The protein-dye solutions are easily processable and form homogeneous thin films exhibiting excellent photophysical and morphological properties, as derived from photoluminescence and AFM data. The obtained results represent the proof of concept of the viability of this bio host-guest system for the development of bioinspired optoelectronic devices.

Hexahomotrioxacalix[3]arene derivatives as ionophores for molecular recognition of dopamine, serotonin and phenylethylamine.

PubMed

Ni, Xin-Long; Rahman, Shofiur; Wang, Shi; Jin, Cheng-Cheng; Zeng, Xi; Hughes, David L; Redshaw, Carl; Yamato, Takehiko

2012-06-21

The lower rim functionalized hexahomotrioxacalix[3]arene derivatives cone-3 and cone-5 bearing three benzyl and three N,N-diethyl-2-aminoethoxy groups, respectively, were synthesized from triol 1. Their complexation with 2-(3,4-dihydroxyphenyl)ethylamine (dopamine), 5-hydroxytryptamine (serotonin), and 2-phenylethylamine (phenethylamine), which have biologically important activities, has been studied by (1)H-NMR spectroscopy. The chemical shifts of the aromatic protons of the host and guest molecules and the up-field shifts of the ethyl protons of the guest molecules strongly suggest the formation of inclusion complexes in solution. The formation of the host-guest complexes is assisted by a hydrogen bond and/or an electrostatic interaction between the host and ammonium ion (RNH(3)(+)) of the guest. The structures of receptors cone-3 and cone-5 have been determined by X-ray crystallography.

Computational study of the interplay between intermolecular interactions and CO2 orientations in type I hydrates.

PubMed

Pérez-Rodríguez, M; Vidal-Vidal, A; Míguez, J M; Blas, F J; Torré, J-P; Piñeiro, M M

2017-01-25

Carbon dioxide (CO 2 ) molecules show a rich orientation landscape when they are enclathrated in type I hydrates. Previous studies have described experimentally their preferential orientations, and some theoretical works have explained, but only partially, these experimental results. In the present paper, we use classical molecular dynamics and electronic density functional theory to advance in the theoretical description of CO 2 orientations within type I hydrates. Our results are fully compatible with those previously reported, both theoretical and experimental, the geometric shape of the cavities in hydrate being, and therefore, the steric constraints, responsible for some (but not all) preferential angles. In addition, our calculations also show that guest-guest interactions in neighbouring cages are a key factor to explain the remaining experimental angles. Besides the implication concerning equation of state hydrate modeling approximations, the conclusion is that these guest-guest interactions should not be neglected, contrary to the usual practice.

Trapping guests within a nanoporous metal-organic framework through pressure-induced amorphization.

PubMed

Chapman, Karena W; Sava, Dorina F; Halder, Gregory J; Chupas, Peter J; Nenoff, Tina M

2011-11-23

The release of guest species from within a nanoporous metal-organic framework (MOF) has been inhibited by amorphization of the guest-loaded framework structure under applied pressure. Thermogravimetric analyses have shown that by amorphizing ZIF-8 following sorption of molecular I(2), a hazardous radiological byproduct of nuclear energy production, the pore apertures in the framework are sufficiently distorted to kinetically trap I(2) and improve I(2) retention. Pair distribution function (PDF) analysis indicates that the local structure of the captive I(2) remains essentially unchanged upon amorphization of the framework, with the amorphization occurring under the same conditions for the vacant and guest-loaded framework. The low, accessible pressure range needed to effect this change in desorption is much lower than in tradition sorbents such as zeolites, opening the possibility for new molecular capture, interim storage, or controlled release applications.

Motion of the guest ion as precursor to the first-order phase transition in the cage system GdB6

NASA Astrophysics Data System (ADS)

Iwasa, Kazuaki; Igarashi, Ryosuke; Saito, Kotaro; Laulhé, Claire; Orihara, Toshihiko; Kunii, Satoru; Kuwahara, Keitaro; Nakao, Hironori; Murakami, Youichi; Iga, Fumitoshi; Sera, Masafumi; Tsutsui, Satoshi; Uchiyama, Hiroshi; Baron, Alfred Q. R.

2011-12-01

The motion of guest Gd ions in oversized boron cages in GdB6 was investigated from phonon spectra measurements obtained by inelastic x-ray scattering. The measured phonon modes soften by about 10% from 300 K down to TN=16 K, in particular, the longitudinal phonon for the propagation vector q1=(1/2,0,0) that characterizes the distorted structure below TN. Besides, the dispersion relation curves show kinklike anomalies at qk=(0.38,0.38,0). The observed results imply that the motion of the guest Gd ion interplays with the f electrons magnetoelastically and with carriers via Fermi surface nesting. The anomalous properties previously reported for this material far above TN originate from the strong electron-phonon coupling, which causes the motion of guest ions as precursors to the first-order phase transition.

77 FR 18259 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... Industrial Resources in Kansas City, Missouri MPS) 2008-2020 Grand Blvd., Kansas City, 12000205 St. Louis...., Lewiston, 12000213 Mitchell County Penland Post Office and General Store, 1162 Penland Rd., Penland...

7. CLOSER OBLIQUE VIEW OF WEST TRUSS AND WEST SIDE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. CLOSER OBLIQUE VIEW OF WEST TRUSS AND WEST SIDE OF SOUTH ABUTMENT; VIEW TO NORTHEAST. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

29 CFR 780.1016 - Use of evergreens and forest products.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the purpose for which evergreens may be harvested under section 13(d). Harvesting of these materials... evergreens are used for wreathmaking by persons other than the homeworkers (see Mitchell v. Hunt, 263 F. 2d...

29 CFR 780.1016 - Use of evergreens and forest products.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the purpose for which evergreens may be harvested under section 13(d). Harvesting of these materials... evergreens are used for wreathmaking by persons other than the homeworkers (see Mitchell v. Hunt, 263 F. 2d...

29 CFR 780.1016 - Use of evergreens and forest products.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the purpose for which evergreens may be harvested under section 13(d). Harvesting of these materials... evergreens are used for wreathmaking by persons other than the homeworkers (see Mitchell v. Hunt, 263 F. 2d...

29 CFR 780.1016 - Use of evergreens and forest products.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the purpose for which evergreens may be harvested under section 13(d). Harvesting of these materials... evergreens are used for wreathmaking by persons other than the homeworkers (see Mitchell v. Hunt, 263 F. 2d...

29 CFR 780.1016 - Use of evergreens and forest products.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the purpose for which evergreens may be harvested under section 13(d). Harvesting of these materials... evergreens are used for wreathmaking by persons other than the homeworkers (see Mitchell v. Hunt, 263 F. 2d...

29 CFR 785.15 - On duty.

Code of Federal Regulations, 2011 CFR

2011-07-01

... plant. For example, a repair man is working while he waits for his employer's customer to get the..., 39 Labor Cases, para. 66,278, 14 W.H. Cases 534 (D.N.M. 1960); Mitchell v. Nicholson, 179 F. Supp...

29 CFR 785.15 - On duty.

Code of Federal Regulations, 2010 CFR

2010-07-01

... plant. For example, a repair man is working while he waits for his employer's customer to get the..., 39 Labor Cases, para. 66,278, 14 W.H. Cases 534 (D.N.M. 1960); Mitchell v. Nicholson, 179 F. Supp...

7. GENERAL VIEW. VIEW FROM SOUTH SIDE OF BROADWAY LOOKING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. GENERAL VIEW. VIEW FROM SOUTH SIDE OF BROADWAY LOOKING NORTHEAST SHOWS PRESENT SENIOR CITIZENS HIGHRISE ON THE WEST AND MARION COUNTY COURTHOUSE ON THE EAST - Mitchell-Anderson House, 1008 Broadway, Hannibal, Marion County, MO

2. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer June 1965 REAR ELEVATION OF HOUSE AND SUMMER KITCHEN (c. 1850) AND STAFF QUARTERS (1933) - Swain-Mitchell House, 1 Vestal Street, Nantucket, Nantucket County, MA

Cookstove Research Update

EPA Science Inventory

This webinar includes the following topics: (1) Introduction and field activities, John Mitchell, (2) STAR (Science To Achieve Results) grants, Terry Keating, (3) LCA (life cycle assessment) report, (4) Mutagenicity study, David DeMarini, (5) Health effects study, Jan Dye, (6) IS...

75 FR 7570 - Federal Advisory Committee; Military Leadership Diversity Commission (MLDC); Meeting Cancellation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... Chief Steven A. Hady, Designated Federal Officer, MLDC, at (703) 602-0838, 1851 South Bell Street, Suite 532, Arlington, VA, E-mail [email protected] . Dated: February 16, 2010. Mitchell S. Bryman...

29 CFR 784.104 - The 1949 amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Labor Standards Amendments of 1949 did not indicate any intention to change in any way the category of... statute as amended 63 Stat. 920” (Mitchell v. Kentucky Finance Co., 359 U.S. 290). In connection with this...

Genetics Home Reference: North American Indian childhood cirrhosis

MedlinePlus

... Chagnon P, Fujiwara TM, Morgan K, Richter A, Hudson TJ, Mitchell GA. Localization of a recessive gene ... J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A. A missense mutation (R565W) in ...

Apollo 14 Mission to Fra Mauro

NASA Technical Reports Server (NTRS)

Beasley, Brian D. (Editor)

1991-01-01

The 1971 Apollo 14 Mission to Fra Mauro, a lunar highland area, is highlighted in this video. The mission's primary goal was the collection of lunar rocks and soil samples and lunar exploration. The soil and rock sampling was for the geochronological determination of the Moon's evolution and its comparison with that of Earth. A remote data collection station was assembled on the Moon and left for continuous data collection and surface monitoring experiments. The Apollo 14 astronauts were Alan B. Shepard, Edgar D. Mitchell, and Stuart A. Rossa. Astronauts Shepard and Mitchell landed on the Moon (February 5, 1971) and performed the sampling, the EVA, and deployment of the lunar experiments. There is film-footage of the lunar surface, of the command module's approach to both the Moon and the Earth, Moon and Earth spacecraft launching and landing, in-orbit command- and lunar-module docking, and of Mission Control.

KIC 8462852: Maria Mitchell Observatory Photographic Photometry 1922 to 1991

NASA Astrophysics Data System (ADS)

Castelaz, M.; Barker, T.

2018-06-01

A new study of the long-term photometric behavior of the the unusual star KIC 8462852 (Boyajian's Star) has been carried out using archival photographic plates from 1922ñ1991 taken at the Maria Mitchell Observatory (MMO). We find five episodes of sudden, several day, decreases in magnitude occurring in 1935, 1966, 1978, and two in 1980. Episodes of sudden increase in magnitude appear to occur in 1967 and 1977. Inspection of archival light curves of KIC 8462852 from two previous studies based on the Harvard and the Sonneberg plate collections finds apparent corresponding events to these observed episodes in the MMO light curve. Also, a general trend of 0.12 ± 0.02 magnitude per century decrease is observed in the MMO light curve, significant, but less than the trend of 0.164 ± 0.013 observed in the Harvard light curve.

Saturn Apollo Program

NASA Image and Video Library

1971-01-31

The moon bound Apollo 14, carrying a crew of three astronauts: Mission commander Alan B. Shepard Jr., Command Module pilot Stuart A. Roosa, and Lunar Module pilot Edgar D. Mitchell, lifted off from launch complex 39A at the Kennedy Space Center on January 31, 1971. It was the third manned lunar landing, the first manned landing in exploration of the lunar highlands, and it demonstrated pinpoint landing capability. The major goal of Apollo 14 was the scientific exploration of the Moon in the foothills of the rugged Fra Mauro region. The lunar surface extravehicular activity (EVA) of astronauts Shepard and Mitchell included setting up an automated scientific laboratory called Apollo Lunar Scientific Experiments Package (ALSEP), and collecting a total of about 95 pounds (43 kilograms) of Moon rock and soil for a geological investigation back on the Earth. The mission safely returned to Earth on February 9, 1971.

Saturn Apollo Program

NASA Image and Video Library

1971-02-05

The moon bound Apollo 14, carrying a crew of three astronauts: Mission commander Alan B. Shepard Jr., Command Module pilot Stuart A. Roosa, and Lunar Module pilot Edgar D. Mitchell, lifted off from launch complex 39A at the Kennedy Space Center on January 31, 1971, and safely returned to Earth on February 9, 1971. It was the third manned lunar landing, the first manned landing in exploration of the lunar highlands, and it demonstrated pinpoint landing capability. The major goal of Apollo 14 was the scientific exploration of the Moon in the foothills of the rugged Fra Mauro region. The extravehicular activity (EVA) of astronauts Shepard and Mitchell included setting up an automated scientific laboratory called Apollo Lunar Scientific Experiments Package (ALSEP), shown here fully deployed. In addition, they collected a total of about 95 pounds (43 kilograms) of Moon rock and soil for a geological investigation back on the Earth.

Apollo 14 crewmen near site of volcanic eruption on Hawaii

NASA Technical Reports Server (NTRS)

1970-01-01

Prime crewmen and backup crewmen of the Apollo 14 mission look over an area near the site of a volcanic eruption in Aloi Alae, Hawaii. Astronauts Alan B. Shepard Jr. (leaning with left hand on ground) and Edgar D. Mitchell (behind Shepard, wearing dark glasses) are the prime crewmen scheduled to walk on the moon. Astronauts Eugene A. Cernan (almost obscured at extreme left) and Joe H. Engle (partially visible, on Cernan's right) are back-up crew commander and lunar module pilot, respectively, for the mission. Others in the photograph are Pat Crosland (in hard hat), a geologist and a park ranger in Hawaii Volcanoes National Park; Michael C McEwen (facing Mitchell) of the Geology Branch, Lunar and Earth Sciences Division, Manned Spacecraft Center; and Astronaut Bruce McCandless II, who made the trip to serve as a spacecraft communicator during simulations of extravehicular activity (EVA) on the lunar surface.

Saturn Apollo Program

NASA Image and Video Library

1971-01-31

Stuart A. Roosa, Apollo 14 Command Module pilot, undergoes a final space suit check prior to liftoff. The Apollo 14, carrying a crew of three astronauts: Roosa; Alan B. Shepard, Jr., Mission Commander; and Edgar D. Mitchell, Lunar Module pilot, lifted off from launch complex 39A at KSC on January 31, 1971. It was the third manned lunar landing, the first manned landing in exploration of the lunar highlands, and it demonstrated pinpoint landing capability. The major goal of Apollo 14 was the scientific exploration of the Moon in the foothills of the rugged Fra Mauro region. The lunar surface extravehicular activity (EVA) of astronauts Shepard and Mitchell included setting up an automated scientific laboratory called Apollo Lunar Scientific Experiments Package (ALSEP), and collecting a total of about 95 pounds (43 kilograms) of Moon rock and soil for a geological investigation back on the Earth. Apollo 14 safely returned to Earth on February 9, 1971.

Editors on Unix

NASA Astrophysics Data System (ADS)

Clayton, C. A.

The purpose of this document is to give new users advice on how to choose which editor to use on Unix machines. Under Unix the default editors are considered to be unfriendly and many users prefer to use other more sophisticated alternatives. However, many such alternatives exist; there is not one single editor that everyone finds acceptable and hence each user must decide for himself or herself which to adopt.

The Lives and Hard Times of Magazine Editors in the Big Apple: A Report on the Society of Magazine Editors' Educators Seminar.

ERIC Educational Resources Information Center

English, John W.

This report chronicles the first Society of Magazine Editors' educators seminar, which was held in New York from May 13-17, 1974, and was attended by ten journalism faculty. The industry's concerns, as expressed through editors, are paper, printing, postage, people, and profit. The Magazine Publishers Association (MPA) seems mostly concerned with…

Views of Iranian medical journal editors on medical research publication.

PubMed

Etemadi, Arash; Raiszadeh, Farbod; Alaeddini, Farshid; Azizi, Fereidoun

2004-01-01

Medical journal editors play an important role in optimizing research publication. This study evaluates the views of Iranian medical journal editors, and their knowledge of medical publication standards. In May 2001, 51 editors from all journals approved by the Ministry of Health were invited to participate, 27 of whom completed the study. A self-administered questionnaire, based on the Uniform Requirements for Manuscripts Submitted to Biomedical Journals (URMS) was used which consisted of 28 questions in 9 subject fields. These fields included: peer review, conflicts of interest, authorship criteria, publication ethics, duplicate publication, mass media, advertising, competing manuscripts, and the Internet. The knowledge of the editors was assessed by a scoring system, with a range of -46 to +44 points. Twenty-three of the participants were editors-in-chief and 4 were managing editors. Their average age was 47.3 +/- 8.7 years and 25 were male. All journals were peer-reviewed, most having 2 or 3 reviewers for each manuscript. Of the journals, 92.6% accepted or rejected an article on the basis of the views of most reviewers and 52%, sometimes or always, used a statistician as a reviewer. Most of the editors believed that writing the first draft and designing the study are authorship criteria, and most of them believed that these 2 are stated in URMS. Seven journals (25.9%) never published advertisements. Among journals that sold advertisements, the most popular policy (85%) was the rejection of advertisements because they advertised harmful products. Out of 27 journals, 12 were accessible on the Internet, and 7 had independent websites. Of the editors, 81.5% thought that a website is useful for their journal. The average knowledge score of the editors was 6.5 +/- 7.5. None had a negative score, 33% scored zero, 45% obtained average scores and 22% obtained good scores. The results show that peer review is favored by all the editors studied, though it seems that journals do not follow clear-cut policies in this regard. Most of the editors, agreed with the statements of URMS to some extent and generally most have average to high knowledge of URMS.

Electrostatically Driven Guest Binding in a Self-Assembled Porous Network at the Liquid/Solid Interface.

PubMed

Iritani, Kohei; Ikeda, Motoki; Yang, Anna; Tahara, Kazukuni; Anzai, Masaru; Hirose, Keiji; De Feyter, Steven; Moore, Jeffrey S; Tobe, Yoshito

2018-05-29

We present here the construction of a self-assembled two-dimensional (2D) porous monolayer bearing a highly polar 2D space to study guest co-adsorption through electrostatic interactions at the liquid/solid interface. For this purpose, a dehydrobenzo[12]annulene (DBA) derivative, DBA-TeEG, having tetraethylene glycol (TeEG) groups at the end of the three alternating alkoxy chains connected by p-phenylene linkers was synthesized. As a reference host molecule, DBA-C10, having nonpolar C 10 alkyl chains at three alternating terminals, was employed. As guest molecules, hexagonal phenylene-ethynylene macrocycles (PEMs) attached by triethylene glycol (TEG) ester and hexyl ester groups, PEM-TEG and PEM-C6, respectively, at each vertex of the macrocyclic periphery were used. Scanning tunneling microscopy observations at the 1,2,4-trichlorobenzene/highly oriented pyrolytic graphite interface revealed that PEM-TEG was immobilized in the pores formed by DBA-TeEG at higher probability because of electrostatic interactions such as dipole-dipole and hydrogen bonding interactions between oligoether units of the host and guest, in comparison to PEM-C6 with nonpolar groups. These observations are discussed based on molecular mechanics simulations to investigate the role of the polar functional groups. When a nonpolar host matrix formed by DBA-C10 was used, however, only phase separation and preferential adsorption were observed; virtually no host-guest complexation was discernible. This is ascribed to the strong affinity between the guest molecules which form by themselves densely packed van der Waals networks on the surface.

A Statistical Analysis of the PPII Propensity of Amino Acid Guests in Proline-Rich Peptides

PubMed Central

Moradi, Mahmoud; Babin, Volodymyr; Sagui, Celeste; Roland, Christopher

2011-01-01

There has been considerable debate about the intrinsic PPII propensity of amino-acid residues in denatured polypeptides. Experimentally, the propensity scale is based on the behavior of guest amino-acid residues placed in the middle of polyproline hosts. We have used classical molecular dynamics simulations, with state-of-the-art force fields to carry out a comprehensive analysis of the conformational equilibria of the proline-based host oligopeptides with single guests. The tracked structural characteristics include the PPII content, the cis/trans isomerization of the prolyl bonds, the puckering of the pyrrolidine rings of the proline residues, and the secondary structural motifs. We find no evidence for an intrinsic PPII propensity in any of the guest amino acids other than proline. Instead, the PPII content as derived from experiments may be explained in terms of: 1), a local correlation between the dihedral angles of the guest amino acid and the proline residue immediately preceding it; and 2), a nonlocal correlation between the cis/trans states of the peptide bonds. In terms of the latter, we find that the presence of a guest (other than proline, tyrosine, or tryptophan) increases the trans content of most of the prolyl bonds, which results in an effective increase of the peptide PPII content. With respect to the local dihedral correlations, we find that these are well described in terms of the so-called odds-ratio statistic. Expressed in terms of free energy language, the PPII content based on the odds-ratio of the relevant residues correlate well with the experimentally measured PPII content. PMID:21320454

How is research publishing going to progress in the next 20 years?: transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Seattle on Wednesday, 20 March 2013.

PubMed

Eaton, Kenneth A; Rex Holland, G; Giannobile, William V; Hancocks, Stephen; Robinson, Peter G; Lynch, Christopher D

2014-03-01

On March 20th 2013, a one-hour session for Editors, Associate Editors, Publishers and others with an interest in scientific publishing was held at the IADR International Session in Seattle. Organised by Kenneth Eaton and Christopher Lynch (Chair and Secretary, respectively, of the British Dental Editors Forum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for Editors, Associate Editors, Publishers and others with an interest in scientific publishing. A follow-up session will take place in Cape Town on 25 June 2014 as part of the annual IADR meeting. The transcript of the Seattle meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/position is also stated, thereafter only their name appears. We are grateful to Stephen Hancocks Ltd. for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to Editors, Associate Editors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in. Copyright © 2014 Elsevier Ltd. All rights reserved.

Guest Molecule Exchange Kinetics for the 2012 Ignik Sikumi Gas Hydrate Field Trial

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Mark D.; Lee, Won Suk

A commercially viable technology for producing methane from natural gas hydrate reservoirs remains elusive. Short-term depressurization field tests have demonstrated the potential for producing natural gas via dissociation of the clathrate structure, but the long-term performance of the depressurization technology ultimately requires a heat source to sustain the dissociation. A decade of laboratory experiments and theoretical studies have demonstrated the exchange of pure CO2 and N2-CO2 mixtures with CH4 in sI gas hydrates, yielding critical information about molecular mechanisms, recoveries, and exchange kinetics. Findings indicated the potential for producing natural gas with little to no production of water and rapidmore » exchange kinetics, generating sufficient interest in the guest-molecule exchange technology for a field test. In 2012 the U.S. DOE/NETL, ConocoPhillips Company, and Japan Oil, Gas and Metals National Corporation jointly sponsored the first field trial of injecting a mixture of N2-CO2 into a CH4-hydrate bearing formation beneath the permafrost on the Alaska North Slope. Known as the Ignik Sikumi #1 Gas Hydrate Field Trial, this experiment involved three stages: 1) the injection of a N2-CO2 mixture into a targeted hydrate-bearing layer, 2) a 4-day pressurized soaking period, and 3) a sustained depressurization and fluid production period. Data collected during the three stages of the field trial were made available after an extensive quality check. These data included continuous temperature and pressure logs, injected and recovered fluid compositions and volumes. The Ignik Sikumi #1 data set is extensive, but contains no direct evidence of the guest-molecule exchange process. This investigation is directed at using numerical simulation to provide an interpretation of the collected data. A numerical simulator, STOMP-HYDT-KE, was recently completed that solves conservation equations for energy, water, mobile fluid guest molecules, and hydrate guest molecules, for up to three gas hydrate guest molecules: CH4, CO2, and N2. The independent tracking of mobile fluid and hydrate guest molecules allows for the kinetic exchange of guest molecules between the mobile fluids and hydrate. The particular interest of this numerical investigation is to determine whether kinetic exchange parameters, determined from laboratory-scale experiments, are directly applicable to interpreting the Ignik Sikumi #1 data.« less

CCoAOMT Down-Regulation Activates Anthocyanin Biosynthesis in Petunia.

PubMed

Shaipulah, Nur Fariza M; Muhlemann, Joëlle K; Woodworth, Benjamin D; Van Moerkercke, Alex; Verdonk, Julian C; Ramirez, Aldana A; Haring, Michel A; Dudareva, Natalia; Schuurink, Robert C

2016-02-01

Anthocyanins and volatile phenylpropenes (isoeugenol and eugenol) in petunia (Petunia hybrida) flowers have the precursor 4-coumaryl coenzyme A (CoA) in common. These phenolics are produced at different stages during flower development. Anthocyanins are synthesized during early stages of flower development and sequestered in vacuoles during the lifespan of the flowers. The production of isoeugenol and eugenol starts when flowers open and peaks after anthesis. To elucidate additional biochemical steps toward (iso)eugenol production, we cloned and characterized a caffeoyl-coenzyme A O-methyltransferase (PhCCoAOMT1) from the petals of the fragrant petunia 'Mitchell'. Recombinant PhCCoAOMT1 indeed catalyzed the methylation of caffeoyl-CoA to produce feruloyl CoA. Silencing of PhCCoAOMT1 resulted in a reduction of eugenol production but not of isoeugenol. Unexpectedly, the transgenic plants had purple-colored leaves and pink flowers, despite the fact that cv Mitchell lacks the functional R2R3-MYB master regulator ANTHOCYANIN2 and has normally white flowers. Our results indicate that down-regulation of PhCCoAOMT1 activated the anthocyanin pathway through the R2R3-MYBs PURPLE HAZE (PHZ) and DEEP PURPLE, with predominantly petunidin accumulating. Feeding cv Mitchell flowers with caffeic acid induced PHZ expression, suggesting that the metabolic perturbation of the phenylpropanoid pathway underlies the activation of the anthocyanin pathway. Our results demonstrate a role for PhCCoAOMT1 in phenylpropene production and reveal a link between PhCCoAOMT1 and anthocyanin production. © 2016 American Society of Plant Biologists. All Rights Reserved.

Philadelphia Infirmary for Nervous Diseases: America's original model of institutional neurology.

PubMed

Pappert, E J

1998-06-01

The role and contributions of the Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases in the development of neurology in 19th-century America are described. American neurology was largely born during the Civil War through the work of S.W. Mitchell at Turner's Lane Hospital. With the closing of this military facility, the United States was left without an institution dedicated to neurologic research and the treatment of nervous system diseases. Nineteenth century archival data, including original Trustees' minutes, annual board of managers reports, patient case books, and published research from the Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases were studied. The Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases promoted the development of neurology in the United States through three main activities. First, it offered patients with primary nervous system diseases, arthritis, and orthopedic disorders specialized care that was unavailable at medical universities. Second, its medical staff, especially Mitchell, provided opportunities for advanced neurologic education. Postgraduate physicians interested in neurologic disease attended formal lectures and directly participated in the operation of outpatient clinics and inpatient rounds. Finally, its formalized record system in the form of case books facilitated neurologic research. These records formed the basis of landmark publications by Mitchell, Sinkler, Osler, and others on rest therapy, spastic palsies, chorea, and other topics. As America's first and comprehensive peacetime neurologic facility, the Philadelphia Orthopedic Hospital and Infirmary for Nervous Diseases fostered the evolution of neurology as a separate, viable specialty in the post-Civil War period and provided a particular focus for the study of interactions among orthopedic, nutritional, and neurologic disorders.

Expedition 28 Docking

NASA Image and Video Library

2011-06-10

Mitchell Fossum, right, son of Expedition 28 NASA Flight Engineer Mike Fossum, is seen at Russian Mission Control in Korolev, Russia speaking to his father shortly after his arrival at the International Space Station on Friday, June 10, 2011. Photo Credit: (NASA/Carla Cioffi)

Special Issue. Return to Progress: A New Politics of Adult Education?

ERIC Educational Resources Information Center

Gurnah, Ahmed; And Others

1994-01-01

"Editorial" (Gurnah); "What Should Further Education Be Accountable For?" (Perry); "Women Not for Turning" (Rose); "Rooting Learning" (Yarnit); "Governors Hold the Key" (Searle); "Back on Track" (Miskin, Hartley); "Quality and Quantity in Higher Education" (Mitchell);…

2. EAST ELEVATION OF BRIDGE SEEN FROM THE NORTHEAST, SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. EAST ELEVATION OF BRIDGE SEEN FROM THE NORTHEAST, SHOWING APPROACH OF CARRS MILL ROAD FROM EAST. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

10. DETAIL OF RUBBLE MASONRY ABUTMENT ON THE SOUTH BANK ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. DETAIL OF RUBBLE MASONRY ABUTMENT ON THE SOUTH BANK AND DISINTEGRATING CONCRETE FACING; VIEW FROM WEST. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

Dance Theatre of Harlem: Inspiring the Deprived

ERIC Educational Resources Information Center

Weil, Henry

1976-01-01

The Dance Theatre of Harlem, which includes both a school and a publicly performing dance company, is described from its inception by its artistic director, Arthur Mitchell, to its current activities. Budgets, student characteristics, and philosophy are discussed. (LBH)

Publications - GMC 64 | Alaska Division of Geological & Geophysical Surveys

Science.gov Websites

sample from the AMOCO Production Company Cathedral River Unit #1 well Authors: Henning, Mitchel, and determination for a 10,650' deep cutting sample from the AMOCO Production Company Cathedral River Unit #1 well

The Role of Knowledge in Alliances: A Meta-Analysis

DTIC Science & Technology

2006-01-01

development, shared manufacturing arrangements, common distribution agreements, and franchising (Grant and Baden-Fuller 2004; Varadarajan and... entreprenuership and firm market performance." Strategic Management Journal, 22(6/7), 701-711. Singh, K., & Mitchell, W. (1996). "Precarious

76 FR 56984 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

... Office of Spectrum Management, 1401 Constitution Avenue, NW., Room 1087, Washington, DC 20230. FOR... Avenue, NW., Room 1087, Washington, DC 20230, or call William Mitchell on (202) 482-8124, and available...

76 FR 54530 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... renewable two-year period. They are the following: Daniel F. Albers John A. Bridges Eddie M. Brown Edwin L.... Johnson Terry R. Jones Randall H. Keil James J. Mitchell Andrew M. Nurnberg Kenneth R. Pedersen Joshua R...

Aviation Simulators for the Desktop: Panel and Demonstrations

NASA Technical Reports Server (NTRS)

Pisanich, Greg; Rosekind, Marl R. (Technical Monitor)

1997-01-01

Panel Members are: Christine M. Mitchell (Georgia Tech), Michael T. Palmer (NASA Langley), Greg Pisani (NASA Ames), and Amy R. Pritchett (MIT). The Panel members are affiliated with aviation human factors groups from NASA Ames, NASA Langley, MITCHELL Department of Aerospace and Aeronautical Engineering, and Georgia Technics Center for Human-Machine Systems Research. Panelists will describe the simulator(s) used in their respective institutions including a description of the FMS aircraft models, software, hardware, and displays. Panelists will summarize previous, on-going, and planned empirical studies conducted with the simulators. Greg Pisanich will describe two NASA Ames simulation systems: the Stone Soup Simulator (SSS), and the Airspace Operations Human Factors Simulation Laboratory. The the Stone Soup Simulator is a desktop-based, research flight simulator that includes mode control, flight management, and datalink functionality. It has been developed as a non-proprietary simulator that can be easily distributed to academic and industry researchers who are collaborating on NASA research projects. It will be used and extended by research groups represented by at least two panelists (Mitchell and Palmer). The Airspace Operations Simulator supports the study of air traffic control in conjunction with the flight deck. This simulator will be used provide an environment in which many AATT and free flight concepts can be demonstrated and evaluated. Mike Palmer will describe two NASA Langley efforts: The Langley Simulator and MD-11 extensions to the NASA Amesbury simulator. The first simulator is publicly available and combines a B-737 model with a high fidelity flight management system. The second simulator enhances the S3 simulator with MD-11 electronic flight displays together with modifications to the flight and FMS models to emulate MD-11 dynamics and operations. Chris Mitchell will describe GT-EFIRT (Georgia Tech-Electronic Flight Instrument Research Tool) and B-757 enhancements to the NASA Ames S3. GT-EFIRT is a medium fidelity simulator used to conduct preliminary studies of the CATS (crew activity tracking system). Like the Langley efforts with S3, the Georgia Tech enhancements will allow it to emulate the dynamics and operations of a widely used glass cockpit. Amy Pritchett will describe the MIT simulator(s) that have been used in a range of research investigating cockpit displays, warning devices, and flight deck-ATC interaction.

From scientist to editor

NASA Astrophysics Data System (ADS)

Novoselov, Kostya S.; Pulizzi, Fabio

2018-06-01

Kostya S. Novoselov, professor of physics at the University of Manchester, UK, has been digging into the details of the life of an editor by asking Fabio Pulizzi, Chief Editor of Nature Nanotechnology, some inside information on his work.

2018 NASA Day of Remembrance

NASA Image and Video Library

2018-01-25

Inside the Center for Space Education at the Kennedy Space Center Visitor Complex, spaceport employees and guests join others throughout NASA for the Day of Remembrance ceremony, honoring the contributions of astronauts who have perished in the conquest of space. Following the ceremony, guests walk to the Space Mirror Memorial. The names of fallen astronauts from Apollo 1, Challenger and Columbia, as well as the astronauts who perished in training and commercial airplane accidents are emblazoned on the monument. Each year spaceport employees and guests join others throughout NASA honoring the contributions of astronauts who have perished in the conquest of space.

Foale examines fresh fruit brought to Mir by the STS-86 crew

NASA Image and Video Library

1997-09-27

S86-E-5299 (27 Sept. 1997) --- Astronaut C. Michael Foale, cosmonaut guest researcher, shows his pleasure over a package of fresh fruit brought aboard Russia?s Mir Space Station by the STS-86 crew aboard the space shuttle Atlantis. This photograph captures Foale in his last hours as a cosmonaut guest researcher aboard Mir. Astronaut David A. Wolf, mission specialist, will replace Foale onboard the Mir, as cosmonaut guest researcher. This photograph was taken with the Electronic Still Camera (ESC) at 23:11:26 GMT on Sept. 27, 1997. Photo credit: NASA

Guest-Release Control in Enzyme-Sensitive, Amphiphilic-Dendrimer-Based Nanoparticles through Photochemical Crosslinking

PubMed Central

Raghupathi, Krishna R.; Azagarsamy, Malar A.; Thayumanavan, S.

2012-01-01

Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme-responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non-covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo-crosslinking is also utilized as a tool to investigate the mode of enzyme-substrate interaction in the context of aggregate-monomer equilibrium. PMID:21887830

Ab initio design of drug carriers for zoledronate guest molecule using phosphonated and sulfonated calix[4]arene and calix[4]resorcinarene host molecules

NASA Astrophysics Data System (ADS)

Jang, Yong-Man; Yu, Chol-Jun; Kim, Jin-Song; Kim, Song-Un

2018-04-01

Monomolecular drug carriers based on calix[n]-arenes and -resorcinarenes containing the interior cavity can enhance the affinity and specificity of the osteoporosis inhibitor drug zoledronate (ZOD). In this work we investigate the suitability of nine different calix[4]-arenes and -resorcinarenes based macrocycles as hosts for the ZOD guest molecule by conducting {\\it ab initio} density functional theory calculations for structures and energetics of eighteen different host-guest complexes. For the optimized molecular structures of the free, phosphonated, sulfonated calix[4]-arenes and -resorcinarenes, the geometric sizes of their interior cavities are measured and compared with those of the host-guest complexes in order to check the appropriateness for host-guest complex formation. Our calculations of binding energies indicate that in gaseous states some of the complexes might be unstable but in aqueous states almost all of the complexes can be formed spontaneously. Of the two different docking ways, the insertion of ZOD with the \\ce{P-C-P} branch into the cavity of host is easier than that with the nitrogen containing heterocycle of ZOD. The work will open a way for developing effective drug delivering systems for the ZOD drug and promote experimentalists to synthesize them.

Computer-science guest-lecture series at Langston University sponsored by the U.S. Geological Survey; abstracts, 1992-93

USGS Publications Warehouse

Steele, K. S.

1994-01-01

Langston University, a Historically Black University located at Langston, Oklahoma, has a computing and information science program within the Langston University Division of Business. Since 1984, Langston University has participated in the Historically Black College and University program of the U.S. Department of Interior, which provided education, training, and funding through a combined earth-science and computer-technology cooperative program with the U.S. Geological Survey (USGS). USGS personnel have presented guest lectures at Langston University since 1984. Students have been enthusiastic about the lectures, and as a result of this program, 13 Langston University students have been hired by the USGS on a part-time basis while they continued their education at the University. The USGS expanded the offering of guest lectures in 1992 by increasing the number of visits to Langston University, and by inviting participation of speakers from throughout the country. The objectives of the guest-lecture series are to assist Langston University in offering state-of-the-art education in the computer sciences, to provide students with an opportunity to learn from and interact with skilled computer-science professionals, and to develop a pool of potential future employees for part-time and full-time employment. This report includes abstracts for guest-lecture presentations during 1992-93 school year.

Burke new Tectonics editor

NASA Astrophysics Data System (ADS)

Kevin C. Burke, National Academy of Sciences/ National Research Council (NAS/NRC), assumed responsibilities as Editor in Chief of the American Geophysical Union (AGU) journal Tectonics at the beginning of 1990, taking over from Raymond A. Price, Queens University, Kingston, Ontario. Asger Berthelsen, University of Copenhagen, Denmark, continues as the European Editor, and Paul F. Hoffman, Geological Society of Canada, assumes the task of North American Editor. Tectonics is a joint publication of AGU and the European Geophysical Society.

Louisa May Alcott's Orchard House

Science.gov Websites

and Her Father! Buy the book from Orchard House Read more about John Matteson's award here Louisa May comments about this site, click to use our Online Guest Book All archival photographs © Louisa May Online Guest Book

Emotions under discussion: gender, status and communication in online collaboration.

PubMed

Iosub, Daniela; Laniado, David; Castillo, Carlos; Fuster Morell, Mayo; Kaltenbrunner, Andreas

2014-01-01

Despite the undisputed role of emotions in teamwork, not much is known about the make-up of emotions in online collaboration. Publicly available repositories of collaboration data, such as Wikipedia editor discussions, now enable the large-scale study of affect and dialogue in peer production. We investigate the established Wikipedia community and focus on how emotion and dialogue differ depending on the status, gender, and the communication network of the [Formula: see text] editors who have written at least 100 comments on the English Wikipedia's article talk pages. Emotions are quantified using a word-based approach comparing the results of two predefined lexicon-based methods: LIWC and SentiStrength. We find that administrators maintain a rather neutral, impersonal tone, while regular editors are more emotional and relationship-oriented, that is, they use language to form and maintain connections to other editors. A persistent gender difference is that female contributors communicate in a manner that promotes social affiliation and emotional connection more than male editors, irrespective of their status in the community. Female regular editors are the most relationship-oriented, whereas male administrators are the least relationship-focused. Finally, emotional and linguistic homophily is prevalent: editors tend to interact with other editors having similar emotional styles (e.g., editors expressing more anger connect more with one another). Emotional expression and linguistic style in online collaboration differ substantially depending on the contributors' gender and status, and on the communication network. This should be taken into account when analyzing collaborative success, and may prove insightful to communities facing gender gap and stagnation in contributor acquisition and participation levels.

75 FR 34074 - Postal Pricing Methods

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... Methods AGENCY: Postal Regulatory Commission. ACTION: Notice of proposed rulemaking. SUMMARY: The... price sensitivity (elasticity) to volumes actually mailed during the rebate program. This method is... indicated by the market elasticity. Mitchell Comments at 4-6. Postal Service method. In its data collection...

11. OBLIQUE VIEW OF EAST TRUSS AND EAST SIDE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. OBLIQUE VIEW OF EAST TRUSS AND EAST SIDE OF SOUTH ABUTMENT, SEEN FROM SOUTH BANK OF WINTER'S RUN. - Mitchell's Mill Bridge, Spanning Winter's Run on Carrs Mill Road, west of Bel Air, Bel Air, Harford County, MD

After the Gold Rush.

ERIC Educational Resources Information Center

Pappas, Alceste T.

1982-01-01

During retrenchment, college chief executive officers are urged to: define their activities, develop realistic budgeting, learn to measure outcomes meaningfully, review the tenure system, use nonacademic staff evaluation, investigate staff productivity, and focus on physical plant efficiency. Available from Peat, Marwick, Mitchell & Co., 345 Park…

75 FR 6818 - Revision to the Manual of Regulations and Procedures for Federal Radio Frequency Management

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-11

... available in the Office of Spectrum Management, 1401 Constitution Avenue, NW, Room 1087, Washington, DC... Avenue, NW, Room 1087, Washington, DC 20230, or call William Mitchell at (202) 482-8124, and available...