Water quality management library. 2. edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckenfelder, W.W.; Malina, J.F.; Patterson, J.W.

1998-12-31

A series of ten books offered in conjunction with Water Quality International, the Biennial Conference and Exposition of the International Association on Water Pollution Research and Control (IAWPRC). Volume 1, Activated Sludge Process, Design and Control, 2nd edition, 1998: Volume 2, Upgrading Wastewater Treatment Plants, 2nd edition, 1998: Volume 3, Toxicity Reduction, 2nd edition, 1998: Volume 4, Municipal Sewage Sludge Management, 2nd edition, 1998: Volume 5, Design and Retrofit of Wastewater Treatment Plants for Biological Nutrient Removal, 1st edition, 1992: Volume 6, Dynamics and Control of the Activated Sludge Process, 2nd edition, 1998: Volume 7: Design of Anaerobic Processes formore » the Treatment of Industrial and Municipal Wastes, 1st edition, 1992: Volume 8, Groundwater Remediation, 1st edition, 1992: Volume 9, Nonpoint Pollution and Urban Stormwater Management, 1st edition, 1995: Volume 10, Wastewater Reclamation and Reuse, 1st edition, 1998.« less

Rail-Highway Crossing Resource Allocation Procedure. User's Guide. 2nd edition.

DOT National Transportation Integrated Search

2006-01-01

This report presents findings from a customer satisfaction study conducted in Cobb County, Georgia. The primary hypothesis of this study is that it is possible to develop customer satisfaction measures that are a reliable determinant of roadway quali...

K-12 Resources on the Internet PLUS: Instructor's Supplement. 2nd Edition.

ERIC Educational Resources Information Center

Junion-Metz, Gail

This volume is a supplement to "K-12 Resources on the Internet: An Instructional Guide" and is intended for teaching trainers that prepare Internet workshops in schools and libraries. It includes the following materials: guidelines on how to use this supplement together with the Instructional Guide in preparing a workshop; tips on how to use the…

The feasibility and concurrent validity of performing the Movement Assessment Battery for Children - 2nd Edition via telerehabilitation technology.

PubMed

Nicola, Kristy; Waugh, Jemimah; Charles, Emily; Russell, Trevor

2018-06-01

In rural and remote communities children with motor difficulties have less access to rehabilitation services. Telerehabilitation technology is a potential method to overcome barriers restricting access to healthcare in these areas. Assessment is necessary to guide clinical reasoning; however it is unclear which paediatric assessments can be administered remotely. The Movement Assessment Battery for Children - 2nd Edition is commonly used by various health professionals to assess motor performance of children. The aim of this study was to investigate the feasibility and concurrent validity of performing the Movement Assessment Battery for Children - 2nd Edition remotely via telerehabilitation technology compared to the conventional in-person method. Fifty-nine children enrolled in a state school (5-11 years old) volunteered to perform one in-person and one telerehabilitation mediated assessment. The order of the method of delivery and the therapist performing the assessment were randomized. After both assessments were complete, a participant satisfaction questionnaire was completed by each child. The Bland-Altman limits of agreement for the total test standard score were -3.15 to 3.22 which is smaller than a pre-determined clinically acceptable margin based on the smallest detectable change. This study establishes the feasibility and concurrent validity of the administration of the Movement Assessment Battery for Children - 2nd Edition via telerehabilitation technology. Overall, participants perceived their experience with telerehabilitation positively. Copyright © 2018 Elsevier Ltd. All rights reserved.

Living With Earthquakes in the Pacific Northwest: A Survivor's Guide, 2nd edition

NASA Astrophysics Data System (ADS)

Hutton, Kate

In 1995, Robert S.Yeats found himself teaching a core curriculum class at Oregon State University for undergraduate nonscience majors, linking recent discoveries on the earthquake hazard in the Pacific Northwest to societal response to those hazards. The notes for that course evolved into the first edition of this book, published in 1998. In 2001, he published a similar book, Living With Earthquakes in California: A Survivors Guide (Oregon State University Press).Recent earthquakes, such as the 2001 Nisqually Mw6.8, discoveries, and new techniques in paleoseismology plus changes in public policy decisions, quickly outdated the first Pacific Northwest edition. This is especially true with the Cascadia Subduction Zone and crustal faults, where our knowledge expands with every scientific meeting.

Teacher Quality Toolkit. 2nd Edition

ERIC Educational Resources Information Center

Lauer, Patricia A.; Dean, Ceri B.; Martin-Glenn, Mya L.; Asensio, Margaret L.

2005-01-01

The Teacher Quality Toolkit addresses the continuum of teacher learning by providing tools that can be used to improve both preservice, and inservice teacher education. Each chapter provides self assessment tools that can guide progress toward improved teacher quality and describes resources for designing exemplary programs and practices. Chapters…

Character Education Connections for School, Home and Community: A Guide for Integrating Character Education. Grades Pre-K through 12. 2nd Edition.

ERIC Educational Resources Information Center

Stirling, Diane

This character education guide, for grades Pre-K through 12, presents field-generated, field-tested ideas for integrating character education with daily learning. The ideas are varied in design, scope, and developmental levels and range from half-hour lessons to school-wide events to year-long courses. Each unit (50 in all) is built on particular…

STDs & HIV: A Guide for Today's Teens. 2nd Edition. Student Manual.

ERIC Educational Resources Information Center

Yarber, William L.

This student workbook describes a prevention education curriculum about sexually transmitted diseases (STDs), including HIV/AIDS, discussing: "Why Learn About STD/HIV?"; "Objectives"; "Self-Test: Discovering What I Know - 1"; Self-Test: Discovering What I Believe - 1"; "STD/HIV Fact #1: The STD/HIV…

Earth Matters: Studies for Our Global Future. 2nd Edition.

ERIC Educational Resources Information Center

Wasserman, Pamela, Ed.

This teacher's guide helps students explore the connection between human population growth and the well-being of the planet. Twelve readings and 34 activities introduce high school students to global society and environmental issues such as climate change, biodiversity loss, gender equality, economics, poverty, energy, wildlife endangerment, waste…

The Complete IEP Guide: How To Advocate for Your Special Ed Child. 2nd Edition.

ERIC Educational Resources Information Center

Siegel, Lawrence M.

This book is intended to help parents of students with disabilities effectively proceed on their own through the Individualized Education Program (IEP) process. Chapters cover the following topics: (1) child advocacy; (2) basic legal concepts of the Individuals with Disabilities Education Act, the IEP, state special education laws, and some…

Psychological First Aid Field Operations Guide. 2nd Edition

ERIC Educational Resources Information Center

Brymer, Melissa; Layne, Christopher; Jacobs, Anne; Pynoos, Robert; Ruzek, Josef; Steinberg, Alan; Vernberg, Eric; Watson, Patricia

2006-01-01

Psychological First Aid is an evidence-informed modular approach to help children, adolescents, adults, and families in the immediate aftermath of disaster and terrorism. Psychological First Aid is designed to reduce the initial distress caused by traumatic events and to foster short- and long-term adaptive functioning and coping. Principles and…

Evaluation of the Battelle Developmental Inventory, 2nd Edition, Screening Test for Use in States' Child Outcomes Measurement Systems under the Individuals with Disabilities Education Act

ERIC Educational Resources Information Center

Elbaum, Batya; Gattamorta, Karina A.; Penfield, Randall D.

2010-01-01

This study evaluated the Battelle Developmental Inventory, 2nd Edition, Screening Test (BDI-2 ST) for use in states' child outcomes accountability systems under the Individuals with Disabilities Education Act. Complete Battelle Developmental Inventory, 2nd Edition (BDI-2), assessment data were obtained for 142 children, ages 2 to 62 months, who…

Internet Power Searching: The Advanced Manual. 2nd Edition. Neal-Schuman NetGuide Series.

ERIC Educational Resources Information Center

Bradley, Phil

This handbook provides information on how Internet search engines and related software and utilities work and how to use them in order to improve search techniques. The book begins with an introduction to the Internet. Part 1 contains the following chapters that cover mining the Internet for information: "An Introduction to Search…

Science Experiments Index for Young People. 2nd Edition.

ERIC Educational Resources Information Center

Pilger, Mary Anne

The purpose of the index is to guide students in finding information on thousands of science experiments for investigative projects and science projects for science fairs. Experiments range from simple to complex and are from 1527 books that are both old and new. The nature and range of the projects and activities are appropriate for primary…

A World of Babies: Imagined Childcare Guides for Eight Societies. 2nd Edition

ERIC Educational Resources Information Center

Gottlieb, Alma; DeLoache, Judy

2016-01-01

Should babies sleep alone in cribs, or in bed with parents? Is talking to babies useful, or a waste of time? "A World of Babies" provides different answers to these and countless other child-rearing questions, precisely because diverse communities around the world hold drastically different beliefs about parenting. While celebrating that…

Better Speeches in Ten Simple Steps. Revised 2nd Edition.

ERIC Educational Resources Information Center

Robinson, James W.

Acknowledging that the fear of public speaking is widespread, this book guides the reader/communicator through 10 steps of writing and presenting a speech. The book is based on the idea that solid preparation and following a few basic rules makes public speaking easier and the finished product more dynamic. The book is divided into the following…

Sex Roles, Past, Present and Future; A Guide to Simulations, Games and Activities. 2nd Edition.

ERIC Educational Resources Information Center

Population Inst., Washington, DC.

This brief listing describes games, activities, awareness exercises and projects which explore the realities and myths about the nature, history and potential of men and women. Among the activities are projects designed for children and adults, for individuals, groups, clubs, couples and classes. They can be used in self-education efforts, in…

Beginning the Principalship: A Practical Guide for New School Leaders. 2nd Edition.

ERIC Educational Resources Information Center

Daresh, John C.

This is a highly practical book for the first-year principal or for the assistant principal looking ahead to promotion. In place of abstract generalities, it offers real-life vignettes and scenarios that may be faced by typical first-year principals. The skill checklists are intended to be realistic and unintimidating. Step-by-step explanations…

The English Teacher's Survival Guide: Ready-To-Use Techniques & Materials for Grades 7-12. 2nd Edition

ERIC Educational Resources Information Center

Brandvik, Mary Lou; McKnight, Katherine S.

2011-01-01

This unique time-saving book is packed with tested techniques and materials to assist new and experienced English teachers with virtually every phase of their job from lesson planning to effective discipline techniques. The book includes 175 easy-to-understand strategies, lessons, checklists, and forms for effective classroom management and over…

Designing Successful Transitions: A Guide for Orienting Students to College. 2nd Edition. The First-Year Experience Monograph Series.

ERIC Educational Resources Information Center

Ward-Roof, Jeanine A., Ed.; Hatch, Cathie, Ed.

This monograph contains 15 papers on aspects of college and university student and family orientation programs. Following a prologue, "Reflections on the Future of Orientation," by M. Lee Upcraft, the papers are: (1) "Today's Students and Their Impact on Orientation and First-Year Programs" (Tony W. Cawthon and Michael Miller);…

The Extreme Searcher's Guide to Web Search Engines: A Handbook for the Serious Searcher. 2nd Edition.

ERIC Educational Resources Information Center

Hock, Randolph

This book aims to facilitate more effective and efficient use of World Wide Web search engines by helping the reader: know the basic structure of the major search engines; become acquainted with those attributes (features, benefits, options, content, etc.) that search engines have in common and where they differ; know the main strengths and…

Getting It Right: Reference Guides for Registering Students with Non-English Names, 2nd Edition. REL 2016-158 v2

ERIC Educational Resources Information Center

Motamedi, Jason Greenberg; Jaffery, Zafreen; Hagen, Allyson; Yoon, Sun Young

2017-01-01

Getting a student's name right is the first step in welcoming him or her to school. Staff members who work with student-level data also know the importance of accurately and consistently recording a student's name in order to track student data over time, match files across data sets, and make meaning from the data. For students whose home…

National Dam Safety Program. Palmer Falls Dam, Upper Hudson River Basin, Saratoga and Warren Counties, New York. Phase I Inspection Report,

DTIC Science & Technology

1980-08-23

MA = -a a (A ILa 0. on 4 04 - 0 4.. 4i 44 4i . 4 4. PN w 4 - at AISA 4, 4. 4 ac I r V tvso l, -Vcp4pnfyw to &A0: 1. 0.V. 494 4...for Nuclear Power Plants, Regulating Guide 1.59, Revision 2, August1977 3. Linsley and Franzini: Water Resources Engineering, Second Edition , McGraw...Hill (1972) 4. W. Viessman, Jr., J. Knapp, G. Lewis, 1977, 2nd Edition , Introduction to Hydrology 5. Ven Te Chow: Handbook of Applied Hydrology, McGraw

Ventilation Technical Guide, 2nd Edition

DTIC Science & Technology

2013-04-12

Typical metals found include lead, cadmium, zinc, and chromium . It is difficult to quantify all of the potential exposures associated with blasting...bases. Many of these booths are used to apply some of the most hazardous substances still found in the inventory, including chromium products and...is important to note that some metals used in welding have OSHA specific standards (lead, cadmium, chromium , beryllium, etc.), potentially

Creating a Sacred Place To Support Young American Indian and Other Learners in Grades K-3. Volume I. 2nd Edition [and] Volume II.

ERIC Educational Resources Information Center

Fox, Sandra J.

This two-volume guide presents ingredients for developing a culturally relevant curriculum for American Indian students in the primary grades. A survey of Indian literature for young children yielded eight topic areas included here. The suggested approach to curriculum development is the integration of reading, language arts, math, and science…

Surviving Your Adolescents: How To Manage and Let Go of Your 13-18 Year Olds. Revised 2nd Edition.

ERIC Educational Resources Information Center

Phelan, Thomas W.

Noting that parents raising adolescents need to know when to be quiet and when to act, as well as what to do when something needs to be done, this guide for parents offers guidelines for handling the complex situations and dilemmas that teenagers often present. Topics covered include managing teenage risk-taking, the relationship between…

Positive Classroom Management. A Step-by-Step Guide to Successfully Running the Show Without Destroying Student Dignity. 2nd Edition.

ERIC Educational Resources Information Center

DiGiulio, Robert

This book provides K-12 teachers with concrete, step-by-step guidance on how to improve student behavior through positive classroom management. It explains how to take control of the classroom, offering an alternative to threats, rewards, and punishments. The book is divided into an introduction and three sections with seven chapters. The…

[Guidelines for external radiotherapy and brachytherapy: introduction to the 2nd edition. Société française de radiothérapie oncologique (SFRO)].

PubMed

Mahé, M-A; Barillot, I; Chauvet, B

2014-10-01

In 2007, a first edition was published with the objective to produce guidelines for optimization, harmonization and homogenization of practices in external radiation therapy in France. The second edition, including brachytherapy, has the same objective and takes into account recent technologic improvements (intensity modulation radiation therapy, stereotactic radiotherapy, and 3-dimension brachytherapy) and recent results of the literature. The first part is about daily use of general principles (quality, security, image-guided radiation therapy) and the second is to describe each step of treatment of main cancers. Copyright © 2014 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

Pelvic Floor Dysfunction

MedlinePlus

... 7 in Beck, D. E., Wexner, S. D., Eds. Fundamentals of Anorectal Surgery, 2nd Edition. WB Saunders, London, ... 18 in Beck, D. E., Wexner, S. D., Eds. Fundamentals of Anorectal Surgery, 2nd Edition. WB Saunders, London, ...

Too Old for This, Too Young for That! Your Survival Guide for the Middle School Years. Updated 2nd Edition

ERIC Educational Resources Information Center

Mosatche, Harriet S.; Unger, Karen

2010-01-01

The transition to middle school can be difficult. Most teens are excited about getting older, but they're often not prepared for some of the challenges that come with growing up. Physical and emotional changes, evolving relationships, and increased expectations at school can all make for some major adjustments. "Too Old for This, Too Young for…

Tips for Managing Your Classroom. Adapted from Chapter 4 of "What To Do With the Kid Who.... Developing Cooperation, Self-Discipline, and Responsibility in the Classroom, 2nd Edition." A SkyLight Guide.

ERIC Educational Resources Information Center

Burke, Kay

This booklet provides proactive guidelines to help teachers manage the classroom environment. The tips explain how to establish procedures and create rules for behavior that will enable teachers to clarify their expectations for the students and reduce the number of classroom incidents that interfere with instruction. The guidelines are intended…

Navy/Marine Corps Manager’s Desktop Guide for CALS Implementation. 2nd Edition

DTIC Science & Technology

1993-06-30

significant process and productivity that CALS initiatives are providing within the Navy infrastructure. CALS programs are on-line and working in today’s Navy...era of declining budgets, CALS is most important in enhancing logistic support productivity to maintain operations and improve readiness. Our...is to be accomplished through the general adoption of a set of procedures and staridards for the production , access, management, maintenance, and

Reviews

NASA Astrophysics Data System (ADS)

2002-11-01

CD-ROM REVIEW (551) Essential Physics BOOK REVIEWS (551) Collins Advanced Science: Physics, 2nd edition Quarks, Leptons and the Big Bang, 2nd edition Do Brilliantly: A2 Physics IGCSE Physics Geophysics in the UK Synoptic Skills in Advanced Physics Flash! The hunt for the biggest explosions in the universe Materials Maths for Advanced Physics

PIRLS 2016 Assessment Framework. 2nd Edition

ERIC Educational Resources Information Center

Mullis, Ina V. S., Ed.; Martin, Michael O., Ed.

2015-01-01

The "PIRLS 2016 Assessment Framework, 2nd Edition" provides the foundation for the three international assessments planned as part of the International Association for the Evaluation of Educational Achievement's Progress in International Reading Literacy Study (PIRLS) 2016: PIRLS, PIRLS Literacy, and ePIRLS. PIRLS represents the…

Book Review: Bioassays with Arthropods: 2nd Edition

USDA-ARS?s Scientific Manuscript database

The technical book "Bioassays with Arthropods: 2nd Edition" (2007. Jacqueline L. Robertson, Robert M. Russell, Haiganoush K, Preisler and N. E. Nevin, Eds. CRC Press, Boca Raton, FL, 224 pp.) was reviewed for the scientific readership of the peer-reviewed publication Journal of Economic Entomology. ...

Technical Adequacy of the Disruptive Behavior Rating Scale-2nd Edition--Self-Report

ERIC Educational Resources Information Center

Erford, Bradley T.; Miller, Emily M.; Isbister, Katherine

2015-01-01

This study provides preliminary analysis of the Disruptive Behavior Rating Scale-2nd Edition--Self-Report, which was designed to screen individuals aged 10 years and older for anxiety and behavior symptoms. Score reliability and internal and external facets of validity were good for a screening-level test.

Test Review: The Profile of Mood States 2nd Edition

ERIC Educational Resources Information Center

Lin, Shuqiong; Hsiao, Yu-Yu; Wang, Miao

2014-01-01

The "Profile of Mood States 2nd Edition" (POMS 2) was published in 2012 by Multi-Health Systems (MHS) to assess transient feelings and mood among individuals aged 13 years and above. Evolving from the original POMS (McNair, Lorr, & Droppleman, 1971, 1992), the POMS 2 was designed for youth (13-17 years old) and adults (18 years old…

A Field Guide for Science Writers - The Official Guide of the National Association of Science Writers

NASA Astrophysics Data System (ADS)

Blum, Deborah; Knudson, Mary; Marantz Henig, Robin

2005-09-01

This is the official text for the National Association of Science Writers. In the eight years since the publication of the first edition of A Field Guide for Science Writing, much about the world has changed. Some of the leading issues in today's political marketplace - embryonic stem cell research, global warming, health care reform, space exploration, genetic privacy, germ warfare - are informed by scientific ideas. Never has it been more crucial for the lay public to be scientifically literate. That's where science writers come in. And that's why it's time for an update to the Field Guide, already a staple of science writing graduate programs across the country. The academic community has recently recognized how important it is for writers to become more sophisticated, knowledgeable, and skeptical about what they write. More than 50 institutions now offer training in science writing. In addition mid-career fellowships for science writers are growing, giving journalists the chance to return to major universities for specialized training. We applaud these developments, and hope to be part of them with this new edition of the Field Guide. In A Field Guide for Science Writers, 2nd Edition, the editors have assembled contributions from a collections of experienced journalists who are every bit as stellar as the group that contributed to the first edition. In the end, what we have are essays written by the very best in the science writing profession. These wonderful writers have written not only about style, but about content, too. These leaders in the profession describe how they work their way through the information glut to find the gems worth writing about. We also have chapters that provide the tools every good science writer needs: how to use statistics, how to weigh the merits of conflicting studies in scientific literature, how to report about risk. And, ultimately, how to write.

Give It a Shot! Toolkit for Nurses and Other Immunization Champions Working with Secondary Schools. 2nd Edition

ERIC Educational Resources Information Center

Boyer-Chu, Lynda; Wooley, Susan F.

2008-01-01

Adolescent immunization saves lives--but promoting immunization takes time and thought, and today's nurses and other health advocates are faced with a host of ever-expanding responsibilities in a time of reduced budgets and staff. This toolkit is thus structured as an easy and reliable resource. This 2nd edition contains: (1) a 64-page manual;…

Curriculum on the Edge of Survival: How Schools Fail to Prepare Students for Membership in a Democracy. 2nd Edition

ERIC Educational Resources Information Center

Heller, Daniel

2012-01-01

Typically, school curriculum has been viewed through the lens of preparation for the workplace or higher education, both worthy objectives. However, this is not the only lens, and perhaps not even the most powerful one to use, if the goal is to optimize the educational system. "Curriculum on the Edge of Survival, 2nd Edition," attempts to define…

Soil Carbon Sequestration and the Greenhouse Effect (2nd Edition)

USDA-ARS?s Scientific Manuscript database

This volume is a second edition of the book “Soil Carbon Sequestration and The Greenhouse Effect”. The first edition was published in 2001 as SSSA Special Publ. #57. The present edition is an update of the concepts, processes, properties, practices and the supporting data. All chapters are new co...

Catering & Hospitality, Serving Food & Drink, Levels 1-3. 2nd Edition. Catering & Hospitality, Reception & Housekeeping, Levels 1-3. Catering & Hospitality, Supervisory Management, Level 3. Catering & Hospitality Management, Level 4. 2nd Edition. National Vocational Qualifications.

ERIC Educational Resources Information Center

Business and Technology Education Council, London (England).

Britain's National Vocational Qualifications (NVQs) are work qualifications that measure what an employee or potential employee can do as well as how much he or she knows and understands about a particular job. Used as written proof of usable workplace skills that can be put to profitable use by an employer, NVQs range from basic Level 1, for…

A Guided Tour of Mathematical Methods - 2nd Edition

NASA Astrophysics Data System (ADS)

Snieder, Roel

2004-09-01

Mathematical methods are essential tools for all physical scientists. This second edition provides a comprehensive tour of the mathematical knowledge and techniques that are needed by students in this area. In contrast to more traditional textbooks, all the material is presented in the form of problems. Within these problems the basic mathematical theory and its physical applications are well integrated. The mathematical insights that the student acquires are therefore driven by their physical insight. Topics that are covered include vector calculus, linear algebra, Fourier analysis, scale analysis, complex integration, Green's functions, normal modes, tensor calculus, and perturbation theory. The second edition contains new chapters on dimensional analysis, variational calculus, and the asymptotic evaluation of integrals. This book can be used by undergraduates, and lower-level graduate students in the physical sciences. It can serve as a stand-alone text, or as a source of problems and examples to complement other textbooks. All the material is presented in the form of problems Mathematical insights are gained by getting the reader to develop answers themselves Many applications of the mathematics are given

Professional Issues in Therapeutic Recreation: On Competence and Outcomes. 2nd Edition

ERIC Educational Resources Information Center

Stumbo, Norma J., Ed.

2009-01-01

The second edition of "Professional Issues in Therapeutic Recreation: On Competence and Outcomes" is greatly expanded to include a wider variety of introductory materials and updates on current professional issues. The second edition represents a timely review of the state of affairs in the profession of therapeutic recreation. This book contains…

Handbook of Research in Education Finance and Policy, 2nd Edition

ERIC Educational Resources Information Center

Ladd, Helen F., Ed.; Goertz, Margaret E., Ed.

2015-01-01

Sponsored by the Association for Education Finance and Policy (AEFP), the second edition of this groundbreaking handbook assembles in one place the existing research-based knowledge in education finance and policy, with particular attention to elementary and secondary education. Chapters from the first edition have been fully updated and revised…

Ethnography, Step by Step (2nd Edition), by David M. Fetterman, Thousand Oaks, Ca: Sage, 1998..

ERIC Educational Resources Information Center

Green, Jennifer C.; Buell, James

2000-01-01

Reviews this edition, which like the first is primarily an organized presentation of fieldwork vignettes and instructive examples from research and evaluation contexts. The presentation is organized by the steps involved in ethnographic fieldwork. This edition is updated with references to electronic technology. (SLD)

Digest of Education Statistics 2016, 52nd Edition. NCES 2017-094

ERIC Educational Resources Information Center

Snyder, Thomas D.; de Brey, Cristobal; Dillow, Sally A.

2018-01-01

The 2016 edition of the "Digest of Education Statistics" is the 52nd in a series of publications initiated in 1962. The "Digest" has been issued annually except for combined editions for the years 1977-78, 1983-84, and 1985-86. Its primary purpose is to provide a compilation of statistical information covering the broad field…

Reading Researchers in Search of Common Ground: The Expert Study Revisited. 2nd Edition

ERIC Educational Resources Information Center

Flippo, Rona F., Ed.

2011-01-01

In "Reading Researchers in Search of Common Ground, Second Edition", Rona F. Flippo revisits her study, in which she set out to find common ground among experts in the much-fragmented field of reading research. The original edition, featuring contributions from participants in the study, commentary from additional distinguished literacy scholars…

Methods for the Determination of Chemical Substances in Marine and Estuarine Environmental Matrices - 2nd Edition

EPA Science Inventory

This NERL-Cincinnati publication, “Methods for the Determination of Chemical Substances in Marine and Estuarine Environmental Matrices - 2nd Edition” was prepared as the continuation of an initiative to gather together under a single cover a compendium of standardized laborato...

Teaching Outside the Box: How to Grab Your Students by Their Brains, 2nd Edition

ERIC Educational Resources Information Center

Johnson, LouAnne

2011-01-01

This second edition of the bestselling book includes practical suggestions for arranging your classroom, talking to students, avoiding the misbehavior cycle, and making your school a place where students learn and teachers teach. The book also contains enlivening Q&A from teachers, letters from students, and tips for grading. This new edition has…

Test Reviews: Newborg, J. (2005). "Battelle Developmental Inventory--Second Edition." Itasca, IL: Riverside

ERIC Educational Resources Information Center

Bliss, Stacy L.

2007-01-01

In this article, the author reviews the Battelle Developmental Inventory, 2nd edition (BDI-2), a criterion-referenced, individually administered, standardized assessment used to measure the developmental skills in children aged birth through 7 years, 11 months. The BDI-2 is composed of 450 items grouped into five domains (Adaptive,…

An Introduction to Computational Physics - 2nd Edition

NASA Astrophysics Data System (ADS)

Pang, Tao

2006-01-01

Preface to first edition; Preface; Acknowledgements; 1. Introduction; 2. Approximation of a function; 3. Numerical calculus; 4. Ordinary differential equations; 5. Numerical methods for matrices; 6. Spectral analysis; 7. Partial differential equations; 8. Molecular dynamics simulations; 9. Modeling continuous systems; 10. Monte Carlo simulations; 11. Genetic algorithm and programming; 12. Numerical renormalization; References; Index.

Instructional Supervision: Applying Tools and Concepts. 2nd Edition

ERIC Educational Resources Information Center

Zepeda, Sally J.

2007-01-01

The first edition of this book was highly regarded by both professors and students for its practicality and its: (1) coverage of tools & strategies to help supervisors work effectively with teachers; (2) up-to-date approach to clinical supervision which includes teacher portfolios, action research, peer coaching, and other innovative practices;…

Reviews

NASA Astrophysics Data System (ADS)

2002-07-01

BOOK REVIEWS (353) Dr Dyer's Academy Further Advanced Physics Physics 11-14, with Biology 11-14 and Chemistry 11-14 Nelson Modular Science: Books 1 and 2 Key Science: Physics, 3rd Edition Nelson Science: Physics, 2nd Edition Physics for AQA: Separate Award, Coordinated Award Physical Processes: A Visual Approach WEB WATCH (359) Physics Favourites: John Miller's selection

Handbook for designing roadways for the aging population.

DOT National Transportation Integrated Search

2014-06-01

The original Older Driver Highway Design Handbook was published by FHWA in 1998 (FHWA-RD-97-135). The : 2nd edition, titled Highway Design Handbook for Older Drivers and Pedestrians (FHWA-RD-01-103) was published in : 2001. This 3rd edition, under a ...

Critical Social Theories. 2nd Edition

ERIC Educational Resources Information Center

Agger, Ben

2006-01-01

Praised for its clarity and accessibility, this fully updated edition of "Critical Social Theories" presents a comprehensive analysis of leading social and cultural theories today. Diverse perspectives are addressed from feminism and cultural studies to postmodernism and critical theory. Written accessibly for students and faculty, the second…

Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing.

PubMed

Heep, Madeleine; Mach, Pia; Reautschnig, Philipp; Wettengel, Jacqueline; Stafforst, Thorsten

2017-01-14

Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1, in both isoforms, p110 and p150. However, further optimization seems necessary as the current design is less efficient for ADAR1 isoforms. Furthermore, we describe hotspots at which the guideRNA itself is edited and show a way to circumvent this auto-editing without losing editing efficiency at the target. Both findings are important for the advancement of site-directed RNA editing as a tool in basic biology or as a platform for therapeutic editing.

Hypersonic-Flow Governing Equations with Electromagnetic Files

DTIC Science & Technology

2009-09-01

CO. [15] B. Finzi, Principio d’azione stazionaria nell’elettrodinamica dei fluidi, Annali di Matematica Pura e Applicata 50 (1960) 321–339. [16] L...Waves, 2nd Edition, W. H. Freeman & Company, San Francisco CA, 1970. [45] E. Persico, Introduzione alla Fisica Matematica , 3rd Edition, Zanichelli

Commercial and Industrial Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook 1 [and] Student Workbook 2.

ERIC Educational Resources Information Center

Kaltwasser, Stan; Flowers, Gary

Commercial and Industrial Wiring, third in a series of three wiring publications, includes the additional technical knowledge and applications required for job entry in the commercial and industrial wiring trade. Instructional materials include a teacher edition, student guide, and two student workbooks. The teacher edition begins with…

Servicios Relacionados. 2nd Edicion. NICHCY News Digest (Related Services. 2nd Edition. NICHCY News Digest).

ERIC Educational Resources Information Center

Mattson, Beverly

This publication, written in Spanish, examines the requirement under the Individuals with Disabilities Education Act (IDEA) that mandates that all children with disabilities have available to them special education and related services designed to meet their unique needs and prepare them for employment and independent living. It investigates what…

Marching to Different Drummers. 2nd Edition.

ERIC Educational Resources Information Center

Guild, Pat Burke; Garger, Stephen

First published in 1985, this revised edition focuses on diversity in education, exploring differences in style to help educators better fulfill their responsibilities and assist people in realizing their potential. Among the new chapters are a discussion of the importance of knowledge about students' culture, learning styles in light of recent…

Robust Team-Optimal and Leader-Follower Policies for Decision Making in C3 (Command, Control and Communications) Systems.

DTIC Science & Technology

1984-07-01

edition , Moscow: Nooka Publishing Co.. 1977; toelith translation of the Ilt edition : t ine with a specific cost structure, we have obtained Functional...651-666, September 1981. [131 L. W. Kantorovich and G. P. Akilov, Functional Analysis, 2nd edition , Moscow: Nauka Publishing Co., 1977; English...translation of the ist edition : Functional Analysis in Normed Spaces, New York: MacMillan, 1964. [14] J. Marschak and R. Radner, Economic Theory of Teams

Partial kinetoplast-mitochondrial gene organization and expression in the respiratory deficient plant trypanosomatid Phytomonas serpens.

PubMed

Maslov, D A; Nawathean, P; Scheel, J

1999-04-30

In plant-dwelling trypanosomatids from the genus Phytomonas, mitochondrial functions, such as cytochrome mediated respiration, ATP production and Krebs cycle, are missing, and cell energetics is based on the glycolysis. Using Blue Native/Tricine-SDS two-dimensional gel electrophoretic analysis, we observed that mitochondrial respiratory Complexes III (cytochrome bc1) and IV (cytochrome c oxidase) were absent in Phytomonas serpens; however, Complex V (ATPase) was present. A deletion of the genes for cytochrome c oxidase subunit III (COIII) and apocytochrome b (Cyb) was identified within the 6234 bp sequenced region of the 31 kb maxicircle kinetoplast DNA. Genes, found in this region, include 12S and 9S ribosomal RNAs, subunits 7, 8 and 9 of NADH dehydrogenase (ND7, ND8 and ND9) and subunit 6 of ATPase (A6 or MURF4), as well as the genes (MURF1, MURF5 and G3) with unknown function. Most genes are actively transcribed and some mRNAs are edited. Fully edited mRNAs for A6 and G3 were abundant, while edited ND7 transcripts were rare, and only partially edited and pre-edited transcripts for ND8 were detected. The data show that the mitochondrial genome of P. serpens is functional, although its functions may be limited to expressing the ATPase and, possibly, NADH dehydrogenase complexes.

Basic Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook 1 [and] Student Workbook 2.

ERIC Educational Resources Information Center

Kaltwasser, Stan; Flowers, Gary; Blasingame, Don

Basic Wiring, first in a series of three wiring publications, serves as the foundation for students enrolled in a wiring program. It is a prerequisite to Commercial and Industrial Wiring or Residential Wiring. Instructional materials include a teacher edition, student guide, and two student workbooks. The teacher edition begins with introductory…

Supporting Individuals with Autism Spectrum Disorder in Recreation. 2nd Edition

ERIC Educational Resources Information Center

Coyne, Phyllis; Fullerton, Ann

2014-01-01

The second edition of "Supporting Individuals with Autism Spectrum Disorder in Recreation" is expanded to provide the most up-to-date, practical approaches for professionals, as well as families, to support the increasing number of individuals with Autism Spectrum Disorder (ASD) of all ages and levels who will be participating in every…

Models of Music Therapy Intervention in School Settings

ERIC Educational Resources Information Center

Wilson, Brian L., Ed.

2002-01-01

This completely revised 2nd edition edited by Brian L. Wilson, addresses both theoretical issues and practical applications of music therapy in educational settings. 17 chapters written by a variety of authors, each dealing with a different setting or issue. A valuable resource for demonstrating the efficacy of music therapy to school…

Hematopathology, 2nd Edition | Center for Cancer Research

Cancer.gov

The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource

Woman's "True" Profession: Voices from the History of Teaching. 2nd Edition

ERIC Educational Resources Information Center

Hoffman, Nancy

2003-01-01

A rich and fascinating portrait of education life in America between 1830 and 1920, "Woman's 'True' Profession" is an indispensable contribution to our understanding of the teaching profession. "Women have always been teachers." So begins this second edition of Nancy Hoffman's classic history of women and the teaching…

Handbook of Positive Psychology in Schools, 2nd Edition

ERIC Educational Resources Information Center

Furlong, Michael J., Ed.; Gilman, Richard, Ed.; Huebner, Scott, Ed.

2014-01-01

Understanding the factors that encourage young people to become active agents in their own learning is critical. Positive psychology is one lens that can be used to investigate the factors that facilitate a student's sense of agency and active school engagement. In the second edition of this groundbreaking handbook, the editors draw together the…

Media Research Techniques. 2nd Edition.

ERIC Educational Resources Information Center

Berger, Arthur Asa

Suggesting it is a good idea for students to try their hands at doing media research themselves, this book presents a number of research projects that students will find interesting and that they can do with minimum experience in a limited amount of time. The second edition has added chapters on experimentation, historical research, comparative…

Residential Wiring. Teacher Edition [and] Student Edition. Third Edition.

ERIC Educational Resources Information Center

Taylor, Mark; Batson, Larry; Carroll, Charles; Ipock, Dan; Leak, Lester; Onstott, Todd

This revised curriculum guide for teachers and students is designed to help prepare students for entry-level employment in the residential wiring trade. The curriculum guide contains six units that cover the following topics: (1) blueprint reading and load calculations; (2) service; (3) rough-in; (4) trim out and troubleshooting; (5) low voltage…

Commercial and Industrial Wiring. Teacher Edition [and] Student Edition. Third Edition.

ERIC Educational Resources Information Center

Kaltwasser, Stan; Flowers, Gary; Aneke, Norbert O.

This revised curriculum guide for teachers and students includes the additional technical knowledge and applications required to help prepare students for job entry in the commercial and industrial wiring trade. The curriculum guide contains 16 units that cover the following topics: (1) blueprint reading and load calculations; (2) tools and…

Really Writing! Ready-To-Use Writing Process Activities for the Elementary Grades. 2nd Edition

ERIC Educational Resources Information Center

Sunflower, Cherlyn

2005-01-01

The second edition of "Really Writing!" provides 40 real-life writing activities designed to capture the attention of young authors (grades 2 through 6) who are just learning the composing process. This book is also a resource for teaching advanced writers who are ready to experiment with a variety of writing and speaking genres. Each of the…

Applied groundwater modeling, 2nd Edition

USGS Publications Warehouse

Anderson, Mary P.; Woessner, William W.; Hunt, Randall J.

2015-01-01

This second edition is extensively revised throughout with expanded discussion of modeling fundamentals and coverage of advances in model calibration and uncertainty analysis that are revolutionizing the science of groundwater modeling. The text is intended for undergraduate and graduate level courses in applied groundwater modeling and as a comprehensive reference for environmental consultants and scientists/engineers in industry and governmental agencies.

Chicano School Failure and Success: Past, Present, and Future. 2nd Edition.

ERIC Educational Resources Information Center

Valencia, Richard R., Ed.

This second edition has been updated and expanded to provide state-of-the-art coverage of the Chicano school experience, with contributions from experts in education and other fields. The book's five sections focus on a comprehensive review of Chicano schooling conditions and outcomes, and implications of the growing Chicano population; language…

Meeting Special Educational Needs in Primary Classrooms: Inclusion and How to Do It. 2nd Edition

ERIC Educational Resources Information Center

Briggs, Sue

2016-01-01

There are greater numbers of children with Special Educational Needs and Disabilities (SEND) now attending mainstream schools. This fully updated and revised edition of "Meeting Special Educational Needs in Primary Classrooms" is written by an experienced teacher, adviser and SEN consultant and explains the challenges that these children…

A Response to Commentaries on "Music Matters: A Philosophy of Music Education," Second Edition (2015)

ERIC Educational Resources Information Center

Elliott, David J.; Silverman, Marissa

2015-01-01

This essay responds to five commentaries on "Music Matters: A Philosophy of Music Education," 2nd edition (2015). Because each author provides a substantial discussion of different aspects of the book, this essay does not attempt to address all points. Instead, we reflect on selected aspects of each scholar's critique.

1001 Best Internet Sites for Educators. 2nd Edition.

ERIC Educational Resources Information Center

Treadwell, Mark

This second edition of a resource designed to help teachers find relevant information on the Internet for both themselves and their students, provides concise reviews of more than 1,000 Web sites sorted by subject area. Each site is evaluated with one to five stars for content, presentation and grade level. Easy-to-follow explanations are provided…

Taking the Lead: New Roles for Teachers and School-Based Coaches, 2nd Edition

ERIC Educational Resources Information Center

Killion, Joellen; Harrison, Cindy

2017-01-01

"Taking the Lead" outlines 10 practical and powerful roles for school-based coaches responsible for helping teachers increase their capacity to serve all students. The second edition is a rich update to Killion and Harrison's essential resource and includes dozens of online tools that support deep exploration and implementation of the…

Water Films, 2nd Edition, 1965-1974.

ERIC Educational Resources Information Center

Canadian National Committee, Ottawa (Ontario).

This is an annotated listing of 455 films on hydrology, as well as on many allied fields. This second edition, much more comprehensive than the first, is not intended to serve as a critical evaluation, but should be used solely as a source of information as to what films are available. All films are listed alphabetically according to their titles…

Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

ERIC Educational Resources Information Center

McGill, Ryan J.

2015-01-01

The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

Forest Adaptation Resources: climate change tools and approaches for land managers, 2nd edition

Treesearch

Christopher W. Swanston; Maria K. Janowiak; Leslie A. Brandt; Patricia R. Butler; Stephen D. Handler; P. Danielle Shannon; Abigail Derby Lewis; Kimberly Hall; Robert T. Fahey; Lydia Scott; Angela Kerber; Jason W. Miesbauer; Lindsay Darling

2016-01-01

Forests across the United States are expected to undergo numerous changes in response to the changing climate. This second edition of the Forest Adaptation Resources provides a collection of resources designed to help forest managers incorporate climate change considerations into management and devise adaptation tactics. It was developed as part of the Climate Change...

What! I Have To Give a Speech? 2nd Edition.

ERIC Educational Resources Information Center

Snyder, Kenneth; Murphy, Thomas J.

Noting that fear of public speaking is shared by people of all types, the second edition of this book offers practical, easy-to-follow strategies for confident and effective public speaking. The book discusses the following aspects of public speaking: what to talk about; how to research a topic; how to organize a speech; how to keep an audience…

Handbook of Response to Intervention: The Science and Practice of Multi-Tiered Systems of Support, 2nd Edition

ERIC Educational Resources Information Center

Jimerson, Shane R., Ed.; Burns, Matthew K., Ed.; VanDerHeyden, Amanda M., Ed.

2016-01-01

The second edition of this essential handbook provides a comprehensive, updated overview of the science that informs best practices for the implementation of response to intervention (RTI) processes within Multi-Tiered Systems of Support (MTSS) to facilitate the academic success of all students. The volume includes insights from leading scholars…

Teaching for Understanding: What It Is and How to Do It. 2nd Edition

ERIC Educational Resources Information Center

Newton, Douglas P.

2011-01-01

At a time when league tables can be everything, examination grades matter. Perhaps more than many would admit, the cost is a lack of understanding. The new edition of this book provides practical advice about how to support understanding in both children and adults. It is for all teachers and lecturers, experienced or otherwise, who want learners…

Test Review: The Psychological Corporation. (2003). "The Early Reading Diagnostic Assessment" (2nd ed.). San Antonio, TX: Psychological Corporation, Harcourt Assessment Company

ERIC Educational Resources Information Center

Gonzalez, Jorge E.

2008-01-01

This article reviews "The Early Reading Diagnostic Assessment, Second Edition" (ERDA-Second Edition), a norm-referenced individually administered diagnostic measure of early reading skills as described in Reading First federal legislation (Part B, Subpart 1 of the Elementary and Secondary Education Act as amended by the No Child Left…

Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers. 2nd Edition

ERIC Educational Resources Information Center

Hanemann, Ulrike, Ed.; Scarpino, Cassandra, Ed.

2016-01-01

The UNESCO Institute for Lifelong Learning (UIL) has published a second edition of "Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers." This compilation of case studies from all world regions presents promising literacy and numeracy programmes that use information and…

Handbook of Aerospace and Operational Physiology, 2nd Edition

DTIC Science & Technology

2016-10-01

1-3 1.1.4. Blood Abnormalities ...4-1 4.1.1. Aviation Psychology and Behavioral Models of the...SYSTEMS INTEGRATION .................................................................................................. 4-73 4.4.1. Human Systems

How to Teach Poetry Writing: Workshops for Ages 8-13. Developing Creative Literacy, 2nd Edition

ERIC Educational Resources Information Center

Morgan, Michaela

2011-01-01

Now in a fully revised and extended second edition, "How to Teach Poetry Writing: Workshops for Ages 8-13" is a practical and activity based resource of writing workshops to help you teach poetry in the primary classroom. Designed to help build writing, speaking and listening skills, this book contains a wide selection of workshops exemplifying a…

101 "Answers" for New Teachers and Their Mentors: Effective Teaching Tips for Daily Classroom Use. Second Edition

ERIC Educational Resources Information Center

Breaux, Annette L.

2011-01-01

The 2nd edition of this bestselling title features brand new strategies plus illustrations! Make sure your new teachers are ready for the realities of the classroom. Be confident that their mentors are focused and effective. Organized so new teachers can read it by themselves, this book can also be studied collaboratively with veteran teachers who…

Tension-Compression Fatigue Behavior of 2D and 3D Polymer Matrix Composites at Elevated Temperature

DTIC Science & Technology

2015-09-21

temperature calibrations, tests procedures and optical microscopy used in this research. 4.1 Mechanical Testing Equipment A Model 810 MTS servo -hydraulic...Composite Materials”. Oxford University Press , New York, NY, 2nd edition, 1994. 4. F.C. Campbell. “Structural Composite Materials” ASM International...M. “Mechanics of Composite Materials”. CRC Press , second Edition, ISBN-10: 156032712x, July 1998. 13. Ruggles-Wrenn, M. B., D. T. Christensen, A. L

International Transplant Nurses Society

MedlinePlus

... to non-members. Purchase your copy today! Transplant Nursing Scope & Standards of Practice, 2nd Edition Click the ... Time Help us make a difference in transplant nursing by directly supporting the valuable research and education ...

Cross-cultural validity of standardized motor development screening and assessment tools: a systematic review.

PubMed

Mendonça, Bianca; Sargent, Barbara; Fetters, Linda

2016-12-01

To investigate whether standardized motor development screening and assessment tools that are used to evaluate motor abilities of children aged 0 to 2 years are valid in cultures other than those in which the normative sample was established. This was a systematic review in which six databases were searched. Studies were selected based on inclusion/exclusion criteria and appraised for evidence level and quality. Study variables were extracted. Twenty-three studies representing six motor development screening and assessment tools in 16 cultural contexts met the inclusion criteria: Alberta Infant Motor Scale (n=7), Ages and Stages Questionnaire, 3rd edition (n=2), Bayley Scales of Infant and Toddler Development, 3rd edition (n=8), Denver Developmental Screening Test, 2nd edition (n=4), Harris Infant Neuromotor Test (n=1), and Peabody Developmental Motor Scales, 2nd edition (n=1). Thirteen studies found significant differences between the cultural context and normative sample. Two studies established reliability and/or validity of standardized motor development assessments in high-risk infants from different cultural contexts. Five studies established new population norms. Eight studies described the cross-cultural adaptation of a standardized motor development assessment. Standardized motor development assessments have limited validity in cultures other than that in which the normative sample was established. Their use can result in under- or over-referral for services. © 2016 Mac Keith Press.

America's Children and the Environment (2003)

EPA Pesticide Factsheets

This 2nd edition report shows continued decline in the number of children with elevated blood lead levels; and reduced exposure to secondhand smoke, air pollution, and drinking water contaminants; but also increasing asthma rates.

A Nurse's Survival Guide to the Ward - Third edition Richards Ann Edwards Sharon A Nurse's Survival Guide to the Ward - Third edition 500pp £19.99 Elsevier 978 0 7020 4603 2 0702046035 [Formula: see text].

PubMed

2013-05-08

This guide is a useful 'friend and companion' to keep close at hand. It is an essential reference for nurses, not only on the ward but in every field of practice where patient care is given. In fact, it makes an accessible guide for all healthcare practitioners.

[Book review] Ducks, geese and swans of North America

USGS Publications Warehouse

Krapu, Gary L.

1983-01-01

This is the 3rd edition of the classic work "The Ducks, Geese and Swans of North America," which was first published in December 1942.  The original edition was authored by Francis C. Kortright with color plates by T. M. Shortt. An authoritative reference on North American waterfowl for many years, the book had become outdated as a result of major advances in the field of waterfowl biology. The need to update the 1st edition culminated in the publication in 1976 of a 2nd edition authored by Frank Bellrose. Readers interested in comparing features of the 1976 edition with other major recent works on North American waterfowl by P. A. Johnsgard and R. S. Palmer should read Weller (1977, Auk 94: 173).

Rockfall catchment area design guide : metric edition : appendices.

DOT National Transportation Integrated Search

2001-12-01

The appendices belong to "Rockfall catchment area design guide : metric edition". : The data gathered from an exhaustive research project consisting of rolling a total of approximately 11,250 rocks off vertical; 4V:1H;2V;1H;1.33V:1H;1.0V:1.0H slopes ...

120 watt continuous wave solar-pumped laser with a liquid light-guide lens and an Nd:YAG rod.

PubMed

Dinh, T H; Ohkubo, T; Yabe, T; Kuboyama, H

2012-07-01

We propose a simple and efficient pumping approach for a high-power solar-pumped laser by using a liquid light-guide lens (LLGL) and a hybrid pumping cavity. A 2×2 m Fresnel lens is used as a primary concentrator to collect natural sunlight; 120 W cw laser power and a 4.3% total slope efficiency are achieved with a 6-mm diameter Nd:YAG rod within a 14-mm diameter LLGL. The corresponded collection efficiency is 30.0 W/m(2), which is 1.5 times larger than the previous record. This result is unexpectedly better than that of Cr:Nd:YAG ceramics. It is because the scattering coefficient of Cr:Nd:YAG ceramics is 0.004cm(1), which is 2 times larger than that of the Nd:YAG crystal, although both have similar saturation gains.

The Futures of Adult Educator(s): Agency, Identity and Ethos. Joint Conference Proceedings of the 2nd ESREA/ReNAdET Meeting and the 4th TQF Seminar (Tallinn, Estonia, November 9-11, 2011)

ERIC Educational Resources Information Center

Heikkinen, Anja, Ed.; Jogi, Larissa, Ed.; Jutte, Wolfgang, Ed.; Zarifis, Georgios K., Ed.

2012-01-01

This edited volume contains the papers presented in the 2nd ESREA|ReNAdet meeting that was jointly organised with the VET & CULTURE Network in the University of Tallinn (Estonia), 9-11 November 2011. The papers that appear in the volume discuss the future (or the futures) of adult educators in respect to issues of developing their identities…

Knee joint replacement

MedlinePlus

... Knee joint replacement - series References American Academy of Orthopedic Surgeons (AAOS) website. Treatment of osteoarthritis of the knee: evidence-based guideline 2nd edition (summary) . www.aaos.org/research/guidelines/TreatmentofOsteoarthritisoftheKneeGuideline.pdf . Updated May 18, 2013. Accessed ...

BNP and NT-proBNP Test

MedlinePlus

... Free Fetal DNA Cerebrospinal Fluid (CSF) Analysis Ceruloplasmin Chemistry Panels Chickenpox and Shingles Tests Chlamydia Testing Chloride ... 488-95. William Clarke. Contemporary Practice in Clinical Chemistry, 2nd Edition Paperback – February 4, 2011. ISBN-13: ...

Insider's Guide to Community College Administration. Second Edition

ERIC Educational Resources Information Center

Jensen, Robert; Giles, Ray

2006-01-01

Drawing from their varied experiences, the authors of this helpful guide, now in its second edition, offer firsthand advice on the skills and attitude needed to succeed as a community college leader. Topics include: (1) Making the right career choices; (2) Thriving and surviving on the job; (3) Navigating institutional politics; (4) Taking the…

Materials data handbook: Aluminum alloy 2014, 2nd edition

NASA Technical Reports Server (NTRS)

Muraca, R. F.; Whittick, J. S.

1972-01-01

A revised edition of the materials data handbook on the aluminum alloy 2014 is presented. The scope of the information presented includes physical and mechanical property data at cryogenic, ambient and elevated temperatures, supplemented with useful information in such areas as material procurement, metallurgy of the alloy, corrosion, environmental effects, fabrication and joining techniques. Design data are presented, as available, and these data are complemented with information on the typical behavior of the alloy.

Narrowing the Gender Gap:Empowering Women through Literacy Programmes: Case Studies from the UNESCO Effective Literacy and Numeracy Practices Database (LitBase) http://www.unesco.org/uil/litbase/. 2nd Edition

ERIC Educational Resources Information Center

Hanemann, Ulrike, Ed.

2015-01-01

UIL has published a second edition of a collection of case studies of promising literacy programmes that seek to empower women. "Narrowing the Gender Gap: Empowering Women through Literacy Programmes" (originally published in 2013 as "Literacy Programmes with a Focus on Women to Reduce Gender Disparities") responds to the…

Ground Viewing Perspective Hyperspectral Anomaly Detection

DTIC Science & Technology

2008-09-01

Statistical Pattern Recognition; 2nd edition, Academic Press, Inc., San Diego, CA, 1990. 7. Crist, E .; Schwartz, C.; Stocker, A. Pairwise adaptive...Research Laboratory: Adelphi, MD, February 2006. 19. Vane, G.; Green, R. O.; Chrien, T. Go.; Enmark, H. T.; Hansen, E . G.; Porter, W. M. The airborne...22. Duda, R. O.; Hart, P. E . Pattern Classification Scene Anal.; Second Edition, New York: J. Wiley & Sons, 2004. 23. Law, A. M.; Kelton, W. D

Immunotherapies in transplantation and cancer: 22nd NAT meeting/2nd NAT LabEx IGO joint meeting; 1-2 June 2017, Nantes, France.

PubMed

Simon, Sylvain; Charpentier, Maud; Anegon, Ignacio; Labarriere, Nathalie

2017-09-01

This 22nd edition of the Nantes Actualités Transplantation annual meeting was co-organized for the second time with the LabEx Immuno-Graft Oncology network. This international meeting was held on 1 and 2 June 2017 in Nantes (western France). The topic of this 2-day meeting was 'Immunotherapies in transplantation and cancer'. This meeting brought together 17 international invited speakers, young researchers and 220 attendees mainly from Europe and North America. It was a unique opportunity to bring together the pioneers and leading immunologists in the fields of transplantation and cancer, focusing on shared mechanisms that control immune responses in organ or bone marrow transplantation and in cancer.

Book review: Reptiles and amphibians: Self-assessment color review

USGS Publications Warehouse

Green, David E.

2017-01-01

No abstract available.Book information: Reptiles and Amphibians: Self-Assessment Color Review. 2nd Edition. By Fredric L. Frye. CRC Press, Taylor and Francis Group, Boca Raton, Florida USA. 2015. 252 pp. ISBN 9781482257601.

Ostomy

MedlinePlus

... Chapter 31. Intestinal Stomas. Chapter in Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D., Eds. ASCRS Textbook of Colon and Rectal Surgery, 2nd Edition. Springer, New York, NY: 2011. National Digestive Disease Information ...

Gross and fine motor skills in children treated for acute lymphoblastic leukaemia.

PubMed

De Luca, Cinzia R; McCarthy, Maria; Galvin, Jane; Green, Jessica L; Murphy, Alexandra; Knight, Sarah; Williams, Jacqueline

2013-06-01

Chemotherapy treatment for acute lymphoblastic leukaemia (ALL) may disrupt motor development, with suggestions that gross and fine motor deficits are different depending on time since treatment. Thirty-seven participants aged between 2.5 to 5 years at the time of diagnosis were assessed using the Movement Assessment Battery for Children, 2nd Edition (MABC-2) and the Bruininks-Oseretsky Test of Motor Proficiency, 2nd Edition, Short Form (BOT-2 SF), and divided into groups (i.e., months-off-treatment): (1) 0-12, (2) 13-24, and (3) 25-60 for comparison. MABC-2 and BOT-2 SF mean total scores fell within the average range. Twenty-six percent of the sample performed in the impaired range on the MABC-2. Group 2 had significantly lower Manual Dexterity scores than the normative population and lower BOT-2 SF scores than Group 1. Most children treated for ALL display appropriate motor skills, yet around a quarter experience general motor difficulties. Time-off-treatment did not affect the prevalence of motor impairments on any measure.

Innovative Remediation Technologies: Field-Scale Demonstration Projects in North America, 2nd Edition

EPA Pesticide Factsheets

This report consolidates key reference information in a matrix that allows project mangers to quickly identify new technologies that may answer their cleanup needs and contacts for obtaining technology demonstration results and other information.

Railroad-highway grade crossing handbook : 2nd edition

DOT National Transportation Integrated Search

1997-11-01

Spread footings are most often less expensive than deep foundations. In an effort to improve the reliability of spread footings, this research project was undertaken. The results consist of: (1) a user friendly microcomputer data base of spread footi...

Global Reach-Global Power Air Force Strategic Vision, Past and Future

DTIC Science & Technology

1995-06-01

10 Patrick E. Conner and Linda K. Lake, Managing Organizational Change (Westport, Connecticut: Praeger...Linda K. Lake. Managing Organizational Change . 2nd edition. Westport, Connecticut: Praeger, 1994. Cound, Dana M. A Leader’s Journey to Quality

Securing Mitigation as Injunctive Relief in Certain Civil Enforcement Settlements (2nd edition)

EPA Pesticide Factsheets

To ensure that EPA's environmental enforcement efforts not only correct and deter illegal conduct but maximize the redress of its consequences, this memorandum is intended to strongly encourage case teams to seek mitigation.

Pruritus-Ani

MedlinePlus

... Dermatology and Pruritis Ani”. Chapter in Beck, D. E., Roberts, P. L., Saclarides, T. J., Senagore, A. J., Stamos, M. J., Wexner, S. D., Eds. ASCRS Textbook of Colon and Rectal Surgery, 2nd Edition. Springer, New York, NY; 2011. American Society of Colon ...

Etudes sociales 30. Sujet B: Interactions entre nations. Unite d'enseignement--Guide. Edition finale = Social Studies 30. Subject B: Interactions between Nations. Teaching Unit--Guide. Final Edition.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Curriculum Branch.

In this Alberta (Canada) teacher's guide, four history units are outlined. These are: (1) Between Two Wars (1919-36); (2) World War II; (3) The Emergence and Interaction of the Superpowers; and (4) Contemporary World Interactions. At the end of each unit, questions are provided for discussion and there is a final synthesis at the end of the…

Efficient CRISPR/Cas9-mediated Targeted Mutagenesis in Populus in the First Generation

PubMed Central

Fan, Di; Liu, Tingting; Li, Chaofeng; Jiao, Bo; Li, Shuang; Hou, Yishu; Luo, Keming

2015-01-01

Recently, RNA-guided genome editing using the type II clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein (Cas) system has been applied to edit the plant genome in several herbaceous plant species. However, it remains unknown whether this system can be used for genome editing in woody plants. In this study, we describe the genome editing and targeted gene mutation in a woody species, Populus tomentosa Carr. via the CRISPR/Cas9 system. Four guide RNAs (gRNAs) were designed to target with distinct poplar genomic sites of the phytoene desaturase gene 8 (PtoPDS) which are followed by the protospacer-adjacent motif (PAM). After Agrobacterium-mediated transformation, obvious albino phenotype was observed in transgenic poplar plants. By analyzing the RNA-guided genome-editing events, 30 out of 59 PCR clones were homozygous mutants, 2 out of 59 were heterozygous mutants and the mutation efficiency at these target sites was estimated to be 51.7%. Our data demonstrate that the Cas9/sgRNA system can be exploited to precisely edit genomic sequence and effectively create knockout mutations in woody plants. PMID:26193631

English L2 Reading: Getting to the Bottom. 2nd Edition

ERIC Educational Resources Information Center

Birch, Barbara M.

2007-01-01

This book remains a comprehensive, myth-debunking examination of how L1 features (orthographic system, phonology, morphology) can influence English L2 reading at the "bottom" of the reading process. It provides a thorough but very accessible linguistic/psycholinguistic examination of the lowest levels of the reading process. It is both theoretical…

Framework for Managing Metadata Security Tags as the Basis for Making Security Decisions.

DTIC Science & Technology

2002-12-01

and Performance,” D.H. Associates, Inc., Sep 2001. [3] Deitel , H. M., and Deitel , P. J., Java How to Program , 3rd Edition, Prentice Hall Inc...1999. [4] Deitel , H. M., Deitel , P. J., and Nieto, T. R., Internet and The World Wide Web: How to Program , 2nd Edition, 2002. [5] Grohn, M. J., A...words) This thesis presents an analysis of a capability to employ CAPCO (Controlled Access Program Coordination Office) compliant Metadata security

The Determinants of Transitions in Youth. Papers from the Conference Organized by the ESF Network on Transitions in Youth, CEDEFOP and GRET (Universitat Autonoma de Barcelona) (Barcelona, Spain, September 20-21, 1993). 2nd Edition. CEDEFOP Panorama. Second Edition.

ERIC Educational Resources Information Center

European Centre for the Development of Vocational Training, Berlin (Germany).

This document consists of the 24 papers delivered at a conference that had five workshops examining various dimensions of the social and occupational transition of young people. The papers are arranged by workshop/session. A summary report precedes the other papers presented during a session. The papers in the session on perspectives on systems,…

Media Evaluations and Dissemination by Indian Americans. A Catalogue of Evaluations of Selected Print and Non-print Materials and Index to Additional Resource Materials Pertaining to American Indians and Alaska Natives. Revised 2nd Edition.

ERIC Educational Resources Information Center

National Indian Education Association, Minneapolis, Minn.

The second edition of the Media Resources Catalogue, this document is considerably reduced in size and includes only evaluated materials. The five sections of this catalogue are as follows: (1) print materials (categorized as fiction and non-fiction, this section includes 55 and 239 citations, respectively and is further categorized in terms of…

TOP500 Supercomputers for November 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack

2003-11-16

22nd Edition of TOP500 List of World s Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.; BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 22nd edition of the TOP500 list of the worlds fastest supercomputers was released today (November 16, 2003). The Earth Simulator supercomputer retains the number one position with its Linpack benchmark performance of 35.86 Tflop/s (''teraflops'' or trillions of calculations per second). It was built by NEC and installed last year at the Earth Simulator Center in Yokohama, Japan.

Optimized guide RNA structure for genome editing via Cas9

PubMed Central

Xu, Jianyong; Lian, Wei; Jia, Yuning; Li, Lingyun; Huang, Zhong

2017-01-01

The genome editing tool Cas9-gRNA (guide RNA) has been successfully applied in different cell types and organisms with high efficiency. However, more efforts need to be made to enhance both efficiency and specificity. In the current study, we optimized the guide RNA structure of Streptococcus pyogenes CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated) system to improve its genome editing efficiency. Comparing with the original functional structure of guide RNA, which is composed of crRNA and tracrRNA, the widely used chimeric gRNA has shorter crRNA and tracrRNA sequence. The deleted RNA sequence could form extra loop structure, which might enhance the stability of the guide RNA structure and subsequently the genome editing efficiency. Thus the genome editing efficiency of different forms of guide RNA was tested. And we found that the chimeric structure of gRNA with original full length of crRNA and tracrRNA showed higher genome editing efficiency than the conventional chimeric structure or other types of gRNA we tested. Therefore our data here uncovered the new type of gRNA structure with higher genome editing efficiency. PMID:29212218

Motivating and Inspiring Teachers: The Educational Leader's Guide for Building Staff Morale. Second Edition

ERIC Educational Resources Information Center

Whitaker, Todd; Whitaker, Beth; Lumpa, Dale

2009-01-01

Like the best-selling first edition, this book is filled with strategies to motivate your staff and maintain a high level of energy at your school. This guide will help all educators approach work every day in an enthusiastic, focused, and positive state of mind. This book will help you: (1) Motivate your faculty with the Friday Focus; (2)…

Day By Day in English: An ESL-SEDAC Daily Living Skills Resource Activities Guide. Final Edition and Resource Activities Packet, Final Edition.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY. Div. of Special Education.

The guide provides daily living experiences built around topics of interest to limited English speaking students in special education programs. Units are organized around eight themes: (1) at school; (2) living at home; (3) community, communication, and travel; (4) clothing and seasons; (5) shopping and food; (6) health, hygiene, and safety; (7)…

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

PubMed Central

Yin, Hao; Song, Chun-Qing; Suresh, Sneha; Kwan, Suet-Yan; Wu, Qiongqiong; Walsh, Stephen; Ding, Junmei; Bogorad, Roman L; Zhu, Lihua Julie; Wolfe, Scot A; Koteliansky, Victor; Xue, Wen; Langer, Robert; Anderson, Daniel G

2018-01-01

CRISPR–Cas9 is a versatile RNA-guided genome editing tool. Here we demonstrate that partial replacement of RNA nucleotides with DNA nucleotides in CRISPR RNA (crRNA) enables efficient gene editing in human cells. This strategy of partial DNA replacement retains on-target activity when used with both crRNA and sgRNA, as well as with multiple guide sequences. Partial DNA replacement also works for crRNA of Cpf1, another CRISPR system. We find that partial DNA replacement in the guide sequence significantly reduces off-target genome editing through focused analysis of off-target cleavage, measurement of mismatch tolerance and genome-wide profiling of off-target sites. Using the structure of the Cas9–sgRNA complex as a guide, the majority of the 3′ end of crRNA can be replaced with DNA nucleotide, and the 5 - and 3′-DNA-replaced crRNA enables efficient genome editing. Cas9 guided by a DNA–RNA chimera may provide a generalized strategy to reduce both the cost and the off-target genome editing in human cells. PMID:29377001

Investigating the Problem of Skill Generalization. 2nd Edition.

ERIC Educational Resources Information Center

Billingsley, Felix; And Others

The booklet describes studies undertaken by the Washington Research Organization (UWRO) to examine generalization processes with severely handicapped students. Section one provides background information on the UWRO, including UWRO's advisory committee, communication with other institutes for research in education of the severely handicapped, and…

Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition

PubMed Central

Madina, Bhaskara R.; Kumar, Vikas; Metz, Richard; Mooers, Blaine H.M.; Bundschuh, Ralf; Cruz-Reyes, Jorge

2014-01-01

Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms. Here, we address compositionally related factors, collectively known as the mitochondrial RNA-binding complex 1 (MRB1) or gRNA-binding complex (GRBC), that contain gRNA, have a dynamic protein composition, and transiently associate with several mitochondrial factors including RNA editing core complexes (RECC) and ribosomes. MRB1 controls editing by still unknown mechanisms. We performed the first next-generation sequencing study of native subcomplexes of MRB1, immunoselected via either RNA helicase 2 (REH2), that binds RNA and associates with unwinding activity, or MRB3010, that affects an early editing step. The particles contain either REH2 or MRB3010 but share the core GAP1 and other proteins detected by RNA photo-crosslinking. Analyses of the first editing blocks indicate an enrichment of several initiating gRNAs in the MRB3010-purified complex. Our data also indicate fast evolution of mRNA 3′ ends and strain-specific alternative 3′ editing within 3′ UTR or C-terminal protein-coding sequence that could impact mitochondrial physiology. Moreover, we found robust specific copurification of edited and pre-edited mRNAs, suggesting that these particles may bind both mRNA and gRNA editing substrates. We propose that multiple subcomplexes of MRB1 with different RNA/protein composition serve as a scaffold for specific assembly of editing substrates and RECC, thereby forming the editing holoenzyme. The MRB3010-subcomplex may promote early editing through its preferential recruitment of initiating gRNAs. PMID:24865612

CO2 Pulsed Laser Damage Mechanism and Plasma Effects (Focused Beam)

DTIC Science & Technology

1986-12-01

sensitive detection methods or large amounts of bombardment have to be used. For the energy ranges and materials associated with 14 nuclear fusion (this...F^ Introduction to Plasma Physics and Controlled Fussion , v 1, 2nd edition. Plenum Press, 1984. 20. Naval Postgraduate School Report NPS-61-82-002

Estimation of Human Power Output from Maximal Vertical Jump and Body Mass

DTIC Science & Technology

1988-01-01

Medicine and Physical Fitness, 23(3):326-332, 1983. 2. Enoka, R.M. Neuromechanical Basis of Kinesiology. Human Kinetics , Champaign Illinois, 1988, pp. 6...1974, pp. 257-258. 5. Kirkendall, D.R., J.J. Gruber, and R.E. Johnson. Measurement and evaluation for physical educators, 2nd edition. Human Kinetics , Champaign

Using Commercial-Off-The-Shelf Speech Recognition Software for Conning U.S. Warships

DTIC Science & Technology

2003-06-01

Linear Regression , 2nd Edition, (John Wiley & Sons, St. Paul, Minnesota, 1985), pp. 267-269. 44 Current Projects About the Sigmoid Curve, Sigmoid Curve...Disabilities Conference, Conference Proceedings, [www.csun.edu/cod/conf/1998/proceedings/csun98_052.htm], as of June 2, 2003. 43 Weisberg, S., Applied

Stochastic Estimation and Control of Queues Within a Computer Network

DTIC Science & Technology

2009-03-01

3]. And NS-2 is a network simulator developed at UC Berkely and is a well known, free, powerful network simulator tool. As will be more discussed...HA011118931033.aspx 7. James Trulove , “Broadband Networking”, CRC Press, 2nd edition, 2000 8. Jonathan Pengelly “MONTE CARLO METHODS” University of Otago

Test Review: Epstein, M. H., & Cullinan, D. (2010). "Scales for Assessing Emotional Disturbance" (2nd Ed.). Austin, TX: Pro-Ed

ERIC Educational Resources Information Center

Lamb, Gordon D.

2011-01-01

The author reviews "Scales for Assessing Emotional Disturbance-Second Edition" (SAED-2; Epstein & Cullinan, 2010), an assessment system primarily designed to assist in determining eligibility for special education services under the category of emotional disturbance (ED), as defined by the "Individuals with Disabilities…

The Handbook for Student Leadership Development. 2nd Edition

ERIC Educational Resources Information Center

Komives, Susan R.; Dugan, John P.; Owen, Julie E.; Slack, Craig; Wagner, Wendy

2011-01-01

This is a must-have book for leadership educators and all student affairs professionals who want to develop impactful leadership programs and the leadership capacity of students. This book contains: (1) Advancing Leadership Education (Susan R. Komives); (2) Leadership Theories (John P. Dugan and Susan R. Komives); (3) Research on College Student…

Behavior and Adaptive Functioning in Adolescents with Down Syndrome: Specifying Targets for Intervention

ERIC Educational Resources Information Center

Jacola, Lisa M.; Hickey, Francis; Howe, Steven R.; Esbensen, Anna; Shear, Paula K.

2014-01-01

Adolescents with Down syndrome can demonstrate increased behavior problems as compared with typical peers. Few studies have explored whether behavior impacts adaptive functioning. Caregiver report from the Behavioral Assessment System for Children, 2nd Edition (BASC-2; Reynolds & Kamphaus, 2004) and the Child Behavioral Checklist (CBCL;…

Classification Accuracy of MMPI-2 Validity Scales in the Detection of Pain-Related Malingering: A Known-Groups Study

ERIC Educational Resources Information Center

Bianchini, Kevin J.; Etherton, Joseph L.; Greve, Kevin W.; Heinly, Matthew T.; Meyers, John E.

2008-01-01

The purpose of this study was to determine the accuracy of "Minnesota Multiphasic Personality Inventory" 2nd edition (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) validity indicators in the detection of malingering in clinical patients with chronic pain using a hybrid clinical-known groups/simulator design. The…

Command and Control: US Army Staffs and the Operations Process

DTIC Science & Technology

2016-05-26

Architecture , 2nd ed. (New York: Elsevier, 2006). 2...Mainly technical experts in logistics and engineering, these proto-staff officers enabled both the Egyptian and Assyrian empires to conquer many of...Platform for Designing Business Architecture . New York: Elsevier, 2006, 2d edition. Gilbert, Felix. “Machiavelli: The Renaissance of the Art of War.” In

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

PubMed Central

Tang, Weixin; Hu, Johnny H.; Liu, David R.

2017-01-01

Programmable sequence-specific genome editing agents such as CRISPR-Cas9 have greatly advanced our ability to manipulate the human genome. Although canonical forms of genome-editing agents and programmable transcriptional regulators are constitutively active, precise temporal and spatial control over genome editing and transcriptional regulation activities would enable the more selective and potentially safer use of these powerful technologies. Here, by incorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, we developed a set of aptazyme-embedded guide RNAs that enable small molecule-controlled nuclease-mediated genome editing and small molecule-controlled base editing, as well as small molecule-dependent transcriptional activation in mammalian cells. PMID:28656978

Production of cold beams of ND{sub 3} with variable rotational state distributions by electrostatic extraction of He and Ne buffer-gas-cooled beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Twyman, Kathryn S.; Bell, Martin T.; Heazlewood, Brianna R.

2014-07-14

The measurement of the rotational state distribution of a velocity-selected, buffer-gas-cooled beam of ND{sub 3} is described. In an apparatus recently constructed to study cold ion-molecule collisions, the ND{sub 3} beam is extracted from a cryogenically cooled buffer-gas cell using a 2.15 m long electrostatic quadrupole guide with three 90° bends. (2+1) resonance enhanced multiphoton ionization spectra of molecules exiting the guide show that beams of ND{sub 3} can be produced with rotational state populations corresponding to approximately T{sub rot} = 9–18 K, achieved through manipulation of the temperature of the buffer-gas cell (operated at 6 K or 17 K),more » the identity of the buffer gas (He or Ne), or the relative densities of the buffer gas and ND{sub 3}. The translational temperature of the guided ND{sub 3} is found to be similar in a 6 K helium and 17 K neon buffer-gas cell (peak kinetic energies of 6.92(0.13) K and 5.90(0.01) K, respectively). The characterization of this cold-molecule source provides an opportunity for the first experimental investigations into the rotational dependence of reaction cross sections in low temperature collisions.« less

[An overview on the collation and revision of medical books by the Bureau for Revising Medical Books in the Northern Song Dynasty].

PubMed

Meng, Yongliang; Liang, Yongxuan

2014-07-01

The Bureau for Revising Medical Books was a temporary agency established by the government of the Northern Song Dynasty in 1057, the 2nd year of Jiayou of Emperor Renzong, exclusively for the edition, revision and publishing of ancient medical books. 11 medical books were revised and edited by 13 Bureau members in a period of 12 years until 1069, the 2nd year of Xining of Emperor ShenZong, which eventually became the final versions until today. 8 medical books were initially planned for the revision, but 11 were actually completed in the end. The time for completing a revision varied from over 10 years at most to less than 1 year at least. Instead of working in the office, the officers of the Bureau for Revising Medical Books did their works at home. The members of the said Bureau came from the Tiju officer of the Bureau for Revising Medical Books and the officials of revising medical books, consisting of both Confucian ministers and medical officers. Confucian ministers played an important role in revising medical books. The Bureau had a strict workflow in electing revising officials, making the project, and the determination of the principles and arrangements of the tasks of editing and proofreading.

Residential Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook.

ERIC Educational Resources Information Center

Taylor, Mark

Residential Wiring, the second publication in a series of three wiring publications, prepares students for entry-level employment in the residential wiring trade. Instructional materials include a teacher edition, student guide, and student workbook. The teacher edition begins with introductory pages, including a training and competency profile,…

Developmentally Appropriate Middle Level Schools. 2nd Edition.

ERIC Educational Resources Information Center

Manning, M. Lee

Noting factors that have contributed to an increased emphasis on developmentally responsive middle level schools, this revised monograph examines early adolescence as a developmental period and explores the physical, psychosocial, and cognitive characteristics of 10- to 15-year-olds. In addition, the monograph provides recommendations concerning…

Sustainable Landscape Systems for Managing Storm Water 2nd Edition

EPA Science Inventory

Rain gardens are designed to capture and infiltrate rainwater in the landscape. These gardens are also called "rain water gardens". Rainwater is routed to the garden and filtered naturally by the plants and soils in the garden. This filtration process removes nutrients and poll...

University of Iowa at TREC 2008 Legal and Relevance Feedback Tracks

DTIC Science & Technology

2008-11-01

Fellbaum, C, [ed.]. Wordnet: An Electronic Lexical Database. Cambridge : MIT Press, 1998. [3] Salton , G. (ed) (1971), The SMART Retrieval System...learning tools and techniques. 2nd Edition. San Francisco : Morgan Kaufmann, 2005. [5] Platt, J . Machines using Sequential Minimal Optimization. [ed.] B

POLLUTION PREVENTION CAST STUDIES COMPENDIUM - 2ND EDITION

EPA Science Inventory

This compendium summarizes a compilation of case studies in the area of pollution prevention. he compendium is divided into 3 sections, featuring 3 of the Pollution Prevention Branch's key programs. An overview of each program is provided at the beginning of each section of the c...

Descriptive Statistical Techniques for Librarians. 2nd Edition.

ERIC Educational Resources Information Center

Hafner, Arthur W.

A thorough understanding of the uses and applications of statistical techniques is integral in gaining support for library funding or new initiatives. This resource is designed to help practitioners develop and manipulate descriptive statistical information in evaluating library services, tracking and controlling limited resources, and analyzing…

Andy Walker | NREL

Science.gov Websites

efficiency and renewable energy projects. His patent on the Renewable Energy Optimization (REO) method of distribution function for time-series simulation Analytical and numerical optimization Project delivery with System Operations and Maintenance: 2nd Edition, 2016, NREL/Sandia/Sunspec Alliance SuNLaMP PV O&M

PRIONS AND THE TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

EPA Science Inventory

This book chapter is an invited, scholarly review of the mechanism(s) of TSEs for the 2nd edition of Metabolic Encephalopathies. Each chapter in the book assumes a professional knowledge of neuroscience and biochemistry, and the focus of the book is on the metabolic basis of dise...

Principles and Applications of Geochemistry, 2nd Edition

NASA Astrophysics Data System (ADS)

Marcantonio, Franco

Many academic geology departments do not include geochemistry in their undergraduate core curriculums. The second edition of Principles and Applications of Geochemistry demonstrates why this should change. Gunter Faure's book clearly shows the important role played by quantitative geochemical analysis in our understanding of Earth processes, both natural and anthropogenic. Intended as an introductory inorganic geochemistry text for senior undergraduates or first-year graduate students, the book makes even the most difficult concepts readily understandable. Beyond its lucid technical explanations, it also includes engaging discussions of the history of geochemistry as a science.

Related Services. 2nd Edition. NICHCY News Digest.

ERIC Educational Resources Information Center

Mattson, Beverly

This publication examines the requirement under the Individuals with Disabilities Education Act (IDEA) that mandates that all children with disabilities have available to them special education and related services designed to meet their unique needs and prepare them for employment and independent living. It investigates what is meant by…

Springer index of viruses, 2nd edition chapter - Aphthovirus, Picornaviridae

USDA-ARS?s Scientific Manuscript database

Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. An outbreak of FMD can have a significant economic impact because of the restrictions on international trade of susceptible animals and their products with FMD-free countries. The disease is controlled by sla...

Wisconsin Workplace Partnership Literacy Program (WPL). Evaluation. 2nd Edition.

ERIC Educational Resources Information Center

Paris, Kathleen A.

The Wisconsin Workplace Partnership Literacy (WPL) Program provided job-specific basic skills education to employees at 11 worksites. A total of 1,441 employees were recruited to participate in on-site competency-based educational activities to upgrade their basic skills sufficiently for job retention or advancement. Participants were encouraged…

Asking the Right Questions: Techniques for Collaboration and School Change. 2nd Edition.

ERIC Educational Resources Information Center

Holcomb, Edie L.

This work provides school change leaders with tools, techniques, tips, examples, illustrations, and stories about promoting school change. Tools provided include histograms, surveys, run charts, weighted voting, force-field analysis, decision matrices, and many others. Chapter 1, "Introduction," applies a matrix for asking questions…

The Fast Track: Facility for Accelerated Service Testing - Transportation Test Center, Pueblo, Colorado, 2nd edition

DOT National Transportation Integrated Search

1978-07-01

This brochure describes the 22 test sections of the Federal Railroad Administration's FAST Track and the various track and mechanical measurements being made as of September 1977 - the end of the first year of operation at the facility. Because of th...

Learning Unlimited: Transforming Learning in the Workplace. 2nd Edition.

ERIC Educational Resources Information Center

Rylatt, Alastair

This book is intended to provide managers, trainers, and others responsible for improving learning within their workplace with the tools, perspectives, and strategies to transform their workplace into a learning organization. Throughout the book, key principles underpinning recent thinking on positive workplace transformation are combined with…

Bibliography of Training Aids. 2nd Edition.

ERIC Educational Resources Information Center

Air Conditioning and Refrigeration Inst., Arlington, VA.

A revision of ED 018 650, this annotated bibliography prepared by the Air-Conditioning and Refrigeration Institute lists training materials, films, and ancillary visual aids available from 34 member companies for use in air-conditioning and refrigeration training programs. Over 160 visual training aids are listed, arranged under the following…

Crossing the Internet Threshold: An Instructional Handbook. 2nd Edition.

ERIC Educational Resources Information Center

Tennant, Roy; Ober, John; Lipow, Anne G.

This how-to manual for the beginning Internet user contains sections on: the authors; an overview of computer networking; Internet basics, including a glossary, information on getting connected and keeping current, and a bibliography; electronic mail, including electronic discussions and electronic journals: Internet Remote Login (Telnet); File…

Systems Engineering of Education I: The Evolution of Systems Thinking in Education, 2nd Edition.

ERIC Educational Resources Information Center

Silvern, Leonard C.

This document methodically traces the development of the fundamental concepts of systems thinking in education from Harbert to contemporary innovators. The discussion explains narrative models, concentrating on educational flowcharting techniques and mathematical models related to developments in engineering and physical science. The presentation…

Rural Poverty Resource Directory. 2nd Edition.

ERIC Educational Resources Information Center

Summers, Gene F., Comp.; And Others

This directory contains names and contact information for over 50 social scientists who are available for consultation on policy issues related to poverty in rural America. Part I is organized by topics that are relevant to rural poverty policies and legislation. Under each topic heading are the names; university affiliations; addresses; and…

How To Help Beginning Teachers Succeed. 2nd Edition.

ERIC Educational Resources Information Center

Gordon, Stephen P.; Maxey, Susan

This book explores the reasons that beginning teachers struggle and provides research-based plans for helping them make the most of their initial teaching years. It proposes Beginning Teacher Assistance Programs (BTAPs) as a practical strategy for success. BTAPs draw on the knowledge and expertise of teachers, principals, central office…

Reviews

NASA Astrophysics Data System (ADS)

2002-03-01

BOOK REVIEWS (164) Salters GCSE Science: Teacher and Technician Resource Pack, Year 10 The NEW World of Mr Tompkins The Heinemann Science Scheme: Book 1 Advanced Physics Readers: Astrophysics Using the Internet in Secondary Schools, 2nd edition CD-ROM REVIEW (168) Particle Physics: A Keyhole to the Birth of Time (version 2) WEB WATCH (169) Hunting for new physics sites CORRECTION (171)

Meal Planning for People with Diabetes, 2nd Edition = Planificacion de Comidas para Personas con Diabetes, 2 Edicion.

ERIC Educational Resources Information Center

National Migrant Resource Program, Inc., Austin, TX.

This booklet provides information about diabetes and meal planning particularly designed for migrant individuals. The first section defines diabetes, explains different types of diabetes, lists results of uncontrolled diabetes, and describes the goals and components of a diabetic meal plan. The second section explains the exchange system of…

The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores

ERIC Educational Resources Information Center

Hus, Vanessa; Lord, Catherine

2014-01-01

The recently published Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) includes revised diagnostic algorithms and standardized severity scores for modules used to assess younger children. A revised algorithm and severity scores are not yet available for Module 4, used with verbally fluent adults. The current study revises the Module 4…

The Autism Diagnostic Observation Schedule, Toddler Module: Standardized Severity Scores

ERIC Educational Resources Information Center

Esler, Amy N.; Bal, Vanessa Hus; Guthrie, Whitney; Wetherby, Amy; Weismer, Susan Ellis; Lord, Catherine

2015-01-01

Standardized calibrated severity scores (CSS) have been created for Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) Modules 1-4 as a metric of the relative severity of autism-specific behaviors. Total and domain CSS were created for the Toddler Module to facilitate comparison to other modules. Analyses included 388 children with ASD…

Understanding Informal and Formal Mathematical Abilities in Mainland Chinese and Chinese-American Children.

ERIC Educational Resources Information Center

Zhou, Zheng; Cheng, Christine; Mottram, Lisa; Rosenblum, Stacey

Informal and formal mathematical abilities were studied in the preschool, kindergarten, and first grade children in Beijing, China and Chinese-American children in New York City. Test of Early Mathematical Abilities-2nd Edition (TEMA-2) was administered to the three groups of children (children from Beijing, Chinese-American from lower-class, and…

Convergent Validity with the BERS-2 Teacher Rating Scale and the Achenbach Teacher's Report Form: A Replication and Extension

ERIC Educational Resources Information Center

Benner, Gregory J.; Beaudoin, Kathleen; Mooney, Paul; Uhing, Brad M.; Pierce, Corey D.

2008-01-01

In the present study, we sought to extend instrument validation research for a strength-based emotional and behavior rating scale, the "Teacher Rating Scale of the Behavior and Emotional Rating Scale-Second Edition" (BERS-2; Epstein, M. H. (2004). "Behavioral and emotional rating scale" (2nd ed.). Austin, TX: PRO-ED) through…

ES4 Terra+Aqua Ed4

Atmospheric Science Data Center

2018-06-26

... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

ES4 Aqua-Xtrk Ed4

Atmospheric Science Data Center

2018-06-27

... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

ES4 Terra-Xtrk Ed4

Atmospheric Science Data Center

2018-06-27

... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

ES9 Terra-Xtrk Ed4

Atmospheric Science Data Center

2018-06-27

... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES9 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications. SCAR-B Block:  ...

ES9 Aqua-Xtrk Ed4

Atmospheric Science Data Center

2018-06-27

... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES9 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications. SCAR-B Block:  ...

Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.

PubMed

Ng, Vicky L; Sorensen, Lisa G; Alonso, Estella M; Fredericks, Emily M; Ye, Wen; Moore, Jeff; Karpen, Saul J; Shneider, Benjamin L; Molleston, Jean P; Bezerra, Jorge A; Murray, Karen F; Loomes, Kathleen M; Rosenthal, Philip; Squires, Robert H; Wang, Kasper; Arnon, Ronen; Schwarz, Kathleen B; Turmelle, Yumirle P; Haber, Barbara H; Sherker, Averell H; Magee, John C; Sokol, Ronald J

2018-05-01

To assess neurodevelopmental outcomes among participants with biliary atresia with their native liver at ages 12 months (group 1) and 24 months (group 2), and to evaluate variables predictive of neurodevelopmental impairment. Participants enrolled in a prospective, longitudinal, multicenter study underwent neurodevelopmental testing with either the Bayley Scales of Infant Development, 2nd edition, or Bayley Scales of Infant and Toddler Development, 3rd edition. Scores (normative mean = 100 ± 15) were categorized as ≥100, 85-99, and <85 for χ 2 analysis. Risk for neurodevelopmental impairment (defined as ≥1 score of <85 on the Bayley Scales of Infant Development, 2nd edition, or Bayley Scales of Infant and Toddler Development, 3rd edition, scales) was analyzed using logistic regression. There were 148 children who completed 217 Bayley Scales of Infant and Toddler Development, 3rd edition, examinations (group 1, n = 132; group 2, n = 85). Neurodevelopmental score distributions significantly shifted downward compared with test norms at 1 and 2 years of age. Multivariate analysis identified ascites (OR, 3.17; P = .01) and low length z-scores at time of testing (OR, 0.70; P < .04) as risk factors for physical/motor impairment; low weight z-score (OR, 0.57; P = .001) and ascites (OR, 2.89; P = .01) for mental/cognitive/language impairment at 1 year of age. An unsuccessful hepatoportoenterostomy was predictive of both physical/motor (OR, 4.88; P < .02) and mental/cognitive/language impairment (OR, 4.76; P = .02) at 2 years of age. Participants with biliary atresia surviving with native livers after hepatoportoenterostomy are at increased risk for neurodevelopmental delays at 12 and 24 months of age. Those with unsuccessful hepatoportoenterostomy are >4 times more likely to have neurodevelopmental impairment compared with those with successful hepatoportoenterostomy. Growth delays and/or complications indicating advanced liver disease should alert clinicians to the risk for neurodevelopmental delays, and expedite appropriate interventions. Clinicaltrials.gov: NCT00061828 and NCT00294684. Copyright © 2018 Elsevier Inc. All rights reserved.

Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

PubMed Central

Farboud, Behnom; Meyer, Barbara J.

2015-01-01

Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs with a GG motif at the 3′ end of their target-specific sequences. All guides designed using this simple principle induced a high frequency of targeted mutagenesis via nonhomologous end joining (NHEJ) and a high frequency of precise DNA integration from exogenous DNA templates via homology-directed repair (HDR). Related guide RNAs having the GG motif shifted by only three nucleotides showed severely reduced or no genome editing. We also combined the 3′ GG guide improvement with a co-CRISPR/co-conversion approach. For this co-conversion scheme, animals were only screened for genome editing at designated targets if they exhibited a dominant phenotype caused by Cas9-dependent editing of an unrelated target. Combining the two strategies further enhanced the ease of mutant recovery, thereby providing a powerful means to obtain desired genetic changes in an otherwise unaltered genome. PMID:25695951

Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in OIF/OEF Female Veterans

DTIC Science & Technology

2013-04-01

Beck depression inventory--2nd Edition Manual . The Psychological Corporation, San Antonio. Beck, A. T., Ward, C. H., Mendelson, M. Mock, J., & Erbaugh...08-2-0022 TITLE: Effectiveness of Cognitive, Exposure, and Skills Group Manualized Treatments in OIF/OEF Female Veterans PRINCIPAL...Approved for public release; distribution unlimited Distribution limited to U.S. Government agencies only; report

Does the Presence of Anxiety and ADHD Symptoms Add to Social Impairment in Children with Autism Spectrum Disorder?

ERIC Educational Resources Information Center

Factor, Reina S.; Ryan, Sarah M.; Farley, Julee P.; Ollendick, Thomas H.; Scarpa, Angela

2017-01-01

Children with autism spectrum disorder (ASD) experience internalizing and externalizing problems at higher rates than typically developing children, which could worsen social impairment. The present study compared impairment scores (social responsiveness scale, 2nd edition; SRS-2 scores) in 57 children (3-17 years, 82.5% male) with ASD, either…

Preventing Unplanned Pregnancy and Completing College: An Evaluation of Online Lessons. 2nd Edition

ERIC Educational Resources Information Center

Antonishak, Jill; Connolly, Chelsey

2014-01-01

The National Campaign to Prevent Teen and Unplanned Pregnancy published free online lessons that help students take action to prevent unplanned pregnancy and complete their education. From the fall of 2012 to the spring of 2014, approximately 2,800 students took the online lessons and participated in pre- and post-lesson evaluation surveys at four…

Consensus Theory in Expert Systems: An Adaptive Inference Framework and Application to Image Understanding

DTIC Science & Technology

1988-12-01

argument schema based on the one devel- oped by Toulmin et al. (1984). In Toulmin’s schema (Figure 4-2), a claim, or 3 conclusion whose merits we are seeking...probability judgment. Cognitive Science, 1985, 9, 309-339. Toulmin , S., Rieke, R., and Janik, A. An introduction to reasoning (2nd Edition). NY

Water Wisdom: 23 Stand-Alone Activities on Water Supply and Water Conservation for High School Students. 2nd Edition.

ERIC Educational Resources Information Center

Massachusetts State Water Resources Authority, Boston.

This water conservation education program for high schools consists of both stand-alone activities and teacher support materials. Lessons are divided into six broad categories: (1) The Water Cycle; (2) Water and Society; (3) Keeping Water Pure; (4) Visualizing Volumes; (5) The Economics of Water Use; and (6) Domestic Water Conservation. The…

Test Review: Gilliam, J. E. (2015), "Attention-Deficit/Hyperactivity Disorder Test" (2nd Ed) [Assessment Instrument]. Austin, TX: Pro-Ed.

ERIC Educational Resources Information Center

Perdue, Elizabeth A.

2016-01-01

The "Attention-Deficit/Hyperactivity Disorder Test-Second Edition" (ADHDT-2) is published through Pro-Ed in Austin, Texas. It was formally published in 2014, following critical revisions of the ADHDT, the reportedly popular initial version of this test that was published in 1995. The ADHDT-2 purports to act as a screener for individuals…

Adaptation of the ABS-S:2 for Use in Spain with Children with Intellectual Disabilities

ERIC Educational Resources Information Center

Garcia Alonso, Isabel; De La Fuente Anuncibay, Raquel; Fernandez Hawrylak, Maria

2010-01-01

As there is a dearth of Spanish-language standardized scales that assess adaptive behavior in children and adolescents with intellectual disabilities (ID), the authors adapted one of the most widely used and studied scales of adaptive behavior in the U.S., the ABS-S:2 (Adaptive Behavior Scale-School, 2nd Edition), and validated it for use in…

Physical Fitness, Physical Training and Occupational Performance of Men and Women in the U.S. Army: A Review of Literature

DTIC Science & Technology

1993-06-01

Report T5/87, Natick, MA, 1986. Fleck, S.J. & Kraemer, W.J. DesigninQ Resistance TraininQ Programs. Human Kinetics Books, Champaign, IL, 1987. Fuller, N.J...Performance: A Physiological Perspective, (2nd Edition). Human Kinetics Books, Champaign, IL, 1991. 22

Working Virtually: Transforming the Mobile Workplace. 2nd Edition

ERIC Educational Resources Information Center

Hoefling, Trina

2017-01-01

Remote working is the new reality, and transactional work--provided by freelancers, contract employees or consultants--has increased exponentially. It is forecast that as much as half the labor force will be working independently and virtually by 2020. Most organizations are still grappling with how to effectively manage their virtual staff and…

Assessment Framework and Specifications (2nd Edition). PIRLS 2006

ERIC Educational Resources Information Center

Mullis, Ina V. S.; Kennedy, Ann M.; Martin, Michael O.; Sainsbury, Marian

2006-01-01

PIRLS 2006 provides countries with the unique opportunity to obtain internationally comparative data about how well their children can read. Countries also will obtain detailed information about home supports for literacy as well as school instruction. For the 35 countries that participated in PIRLS 2001, PIRLS 2006 will provide information on…

Appalachian Issues and Resources, 2nd Edition.

ERIC Educational Resources Information Center

Harb, Jim; And Others

While the format is designed to be introductory (for use in classes, community groups, churches, etc.), the catalog is meant to be used by all kinds of people concerned with building a new Appalachia, "faithful to the traditions and the hopes of its people." Each topical section begins with an introduction and then lists issues and…

Learning Opportunities beyond the School. 2nd Edition.

ERIC Educational Resources Information Center

Hatcher, Barbara, Ed.; Beck, Shirley S., Ed.

The fact that much of learning occurs beyond school walls points to the need for a holistic approach to education. Such an approach involves planned cooperative links between family and the formal and informal learning environments that exist in the community. This monograph advocates such a holistic approach, discussing not only the value of…

The Great Irish Famine. 2nd Edition.

ERIC Educational Resources Information Center

Mullin, James

Between 1845 and 1850, more than a million Irish starved to death while massive quantities of food were being exported from their country. A half million were evicted from their homes during the potato blight. A million and a half emigrated to the United States, Britain, and Australia, often on board rotting, overcrowded "coffin ships."…

Presentation and Analysis of Financial Management Information. 2nd Edition.

ERIC Educational Resources Information Center

Kenton, Jay D.

This book is designed to help financial and other managers of colleges and universities in identifying and responding to the needs of individuals and groups requesting management information. The book attempts to facilitate the communication process through management reports. In addition to guidance on report preparation and data analysis, the…

Promoting Decision-Making Skills by Youth with Disabilities: Health, Education, and Vocational Choices. 2nd Edition. CYDLINE Reviews.

ERIC Educational Resources Information Center

Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

This annotated bibliography offers background information and resource information on decision-making issues for young adults with chronic conditions. The bibliography includes books, journal articles, booklets, audiotapes, and videotapes. For each item listed in the bibliography, the following information is provided: author; title; source; and…

Teaching Russian Studies, 2nd Edition

ERIC Educational Resources Information Center

Winpenny, Patricia; Cadwell, Katherine Weeks; Cadwell, Louise; Harrison, Ryan; Starbird, Caroline

2004-01-01

This book is for those who want to teach about the life, history, language or culture of Russia and the former Soviet Union. Students will learn about the states of the former Soviet Union and the current political structure of Russia. Information is drawn from interviews with Russian children, traditional folktales, maps, original Russian…

Leadership Development of Team Captains in Collegiate Varsity Athletics

ERIC Educational Resources Information Center

Grandzol, Christian; Perlis, Susan; Draina, Lois

2010-01-01

This study examined the leadership development of team captains and student-athletes engaged in NCAA Division III intercollegiate athletics at 6 private institutions of higher education. Student-athletes in the sports of men's and women's soccer, women's field hockey, men's and women's cross country, and women's tennis completed the 2nd edition of…

The Challenge of Problem-Based Learning. 2nd Edition.

ERIC Educational Resources Information Center

Boud, David, Ed.; Feletti, Grahame I., Ed.

Problem-based learning is an approach to structuring the curriculum which involves confronting students with problems from practice which provide a stimulus for learning. However, there are many possible forms that a curriculum and process for teaching and learning might take and still be compatible with this definition. This book explores these…

Advanced Dairy Unit for Advanced Livestock Production Curriculum. Selected Readings. AGDEX 410/00.

ERIC Educational Resources Information Center

Coday, Stan; Stewart, Bob R.

These selected readings are designed to supplement James Gillespie's "Modern Livestock and Poultry Production" (2nd edition) as the the student reference for the advanced dairy unit. Readings are provided for 18 lessons. Topics include profitability of the dairy enterprise; production costs for dairy; comparative advantages of dairy; milk…

Film Handbook. Communication Manual. 2nd Edition.

ERIC Educational Resources Information Center

Beuthner, Reginald, Comp.; And Others

Reference material is provided in this book for editors, producers, camera and sound technicians, others working in film, and film students. Each chapter is a self-contained unit about specific aspects of film-making, designed to accompany film courses being offered by the University of the West Indies, the Jamaica Broadcasting Corporation, and…

Behavior Management Strategies for Teachers. A Student Workbook. 2nd Edition.

ERIC Educational Resources Information Center

Harlan, Joan C.; Rowland, Sidney T.

This student workbook is designed to accompany the textbook, "Behavior Management Strategies for Teachers," helping to reinforce understanding of the basic principles described in the companion textbook. It presents a summary of the key concepts in each of the workbook's 15 chapters. Questions in this student workbook are based on each…

Vermont Public Library Almanac: A Compendium of Often-Answered Questions. 2nd Edition.

ERIC Educational Resources Information Center

Kotch, Marianne

This document contains brief answers to some of the most frequently raised issues related to running a small Vermont public library. Areas covered include accessibility, the American Library Association, automation, awards, binding, services for the blind and physically handicapped, the Board of Libraries, the Board of Trustees, book dealers, book…

77 FR 6090 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... information can be pre-populated from defense accounting system data and edited, if necessary with a series of...: Federal Docket Management System Office, 4800 Mark Center Drive, 2nd Floor, East Tower, Suite 02G09... site to obtain contractor work force information, based on the Army system located at https://cmra.DoD...

Student Learning Support Programmes That Demonstrate Tangible Impact on Retention, Pass Rates & Completion. 2nd Edition

ERIC Educational Resources Information Center

Manalo, Emmanuel, Ed.; Marshall, Jenny, Ed.; Fraser, Cath, Ed.

2010-01-01

This report comprises summations and brief case descriptions of some of the effective programmes and other support mechanisms that New Zealand Tertiary Learning Advisors (TLAs) provide for students in universities, polytechnics, institutes of technology, and other tertiary institutions. The programmes demonstrate tangible impact on student…

Dilemmas in Medicine, 2nd Edition 1977. CEM Probe.

ERIC Educational Resources Information Center

Undy, Harry, Ed.

Published for secondary school youth in England, the PROBE series presents provocative information and discussion questions on topical themes. The focus of this issue is on aspects of medicine which raise moral dilemmas for doctors, patients, and society in general. This issue contains case studies which illustrate ethical questions raised by the…

Becoming a Fundraiser: The Principles and Practice of Library Development. 2nd Edition.

ERIC Educational Resources Information Center

Steele, Victoria; Elder, Stephen D.

This resource presents the tools necessary for bringing librarians' development and fundraising skills up to the level necessary to lead an effective campaign. The book points out that there are significant differences between raising money for libraries, especially academic libraries, and raising money for other types of organizations. It shows…

78 FR 37463 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

... Total Coliform Total Coliform 9221 A, B, C..... 9221 A, B, C..... Fermentation Technique. Total Coliform... Methodology category Method SM 22nd Edition \\28\\ Total Coliforms Lactose Fermentation Standard Total 9221 B.1, B.2 Methods. Coliform Fermentation Technique. Enzyme Substrate Colilert[supreg].... 9223 B Methods...

Trust Matters: Leadership for Successful Schools, 2nd Edition

ERIC Educational Resources Information Center

Tschannen-Moran, Megan

2014-01-01

Make your school soar by escalating trust between teachers, students, and families. Trust is an essential element in all healthy relationships, and the relationships that exist in your school are no different. How can your school leaders or teachers cultivate trust? How can your institution maintain trust once it is established? These are the…

The Online Classroom: Teaching with the Internet. 2nd Edition.

ERIC Educational Resources Information Center

Cotton, Eileen Guiffre

Presenting a wide array of Internet addresses and sample lessons, this book shows how teachers can integrate the Internet into their K-12 curriculum to actively involve students. The ideas and lessons in the book help students to communicate with people in faraway places; gather information from around the globe; develop sophisticated research…

Catalan: The Catalan Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Areny, Maria, Comp.; Mayans, Pere, Comp.; Forniès, David, Comp.

2013-01-01

Regional dossiers aim at providing a concise description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

The principles of radio engineering and antennas. II Antennas (2nd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Belotserkovskii, G. B.

This book represents the second part of a textbook for technical schools. The characteristics and parameters of antennas are considered along with transmission lines, the theory of single dipoles and radiator systems, and the technological realization of elements and units of the antenna-feeder system, taking into account filters and multiport networks for microwave communications applications, and ferrite circulators and isolators. The first edition of this textbook was published in 1969. For the current edition, the material in the first edition has been revised, and new material has been introduced. Much attention is given to microwave antennas, including, in particular, arrays with electrical scanning characteristics. Other topics discussed are related to the general principles of antennas, the matching of the impedance of transmission lines, the elements of transmission lines, aperture-type antennas for microwaves, and the functional characteristics of antennas for ultrashort waves.

Solar Energy: Instructor Guides, Labs and Tests. First Edition.

ERIC Educational Resources Information Center

Orsak, Charles G., Jr.; And Others

Instructor guides are provided for each of 11 courses in a 2-year associate degree program in solar technology. The semester-length solar courses are broken down into modules which correspond roughly to a 1- to 2-week block of instruction. Each guide presents a course description, course objectives, references for further information, and a…

Self-Motivated Personal Career Planning Program. Planner's Guide. [Student Edition].

ERIC Educational Resources Information Center

Walter, Verne

The Self-Motivated Personal Career Planning guide for students presents a process of self-assessment and goal-setting. An overview and rationale of the program and instructions and procedures are discussed in Chapters 1 and 2. The remainder of the guide consists of procedural steps for (1) self-assessment and (2) review and planning.…

Self-Study and Evaluation Guide/1968 Edition. Section D-2B: Orientation on Mobility Services. (Dog Guide Program Only).

ERIC Educational Resources Information Center

National Accreditation Council for Agencies Serving the Blind and Visually Handicapped, New York, NY.

This self-study and evaluation guide on orientation and mobility services (dog guide program emphasis) is one of 28 guides designed for organizations undertaking a self-study as part of the process for accreditation from the National Accreditation Council (NAC) for agencies serving the blind and visually handicapped. Provided are lists of…

Peace and World Order Studies: A Curriculum Guide. Fourth Edition.

ERIC Educational Resources Information Center

Wien, Barbara J., Ed.

The fourth edition of this curriculum guide will help college, university, and secondary school educators design and update courses, familiarize themselves with new literature and resources, and plan and justify new academic programs in the study of global problems. While syllabus categories remain the same as in previous editions, several new…

Shielded Metal Arc Pipe Welding. Teacher Edition. Second Edition.

ERIC Educational Resources Information Center

Fortney, Clarence; And Others

This second edition of the shielded metal arc pipe welding curriculum guide presents both basic and advanced pipe welding skills. All specifications for procedure and welder qualification are presented according to national standards. The standards also include the test position for both groove and fillet pipe welding. The guide contains three…

Enhanced guide-RNA design and targeting analysis for precise CRISPR genome editing of single and consortia of industrially relevant and non-model organisms.

PubMed

Mendoza, Brian J; Trinh, Cong T

2018-01-01

Genetic diversity of non-model organisms offers a repertoire of unique phenotypic features for exploration and cultivation for synthetic biology and metabolic engineering applications. To realize this enormous potential, it is critical to have an efficient genome editing tool for rapid strain engineering of these organisms to perform novel programmed functions. To accommodate the use of CRISPR/Cas systems for genome editing across organisms, we have developed a novel method, named CRISPR Associated Software for Pathway Engineering and Research (CASPER), for identifying on- and off-targets with enhanced predictability coupled with an analysis of non-unique (repeated) targets to assist in editing any organism with various endonucleases. Utilizing CASPER, we demonstrated a modest 2.4% and significant 30.2% improvement (F-test, P < 0.05) over the conventional methods for predicting on- and off-target activities, respectively. Further we used CASPER to develop novel applications in genome editing: multitargeting analysis (i.e. simultaneous multiple-site modification on a target genome with a sole guide-RNA requirement) and multispecies population analysis (i.e. guide-RNA design for genome editing across a consortium of organisms). Our analysis on a selection of industrially relevant organisms revealed a number of non-unique target sites associated with genes and transposable elements that can be used as potential sites for multitargeting. The analysis also identified shared and unshared targets that enable genome editing of single or multiple genomes in a consortium of interest. We envision CASPER as a useful platform to enhance the precise CRISPR genome editing for metabolic engineering and synthetic biology applications. https://github.com/TrinhLab/CASPER. ctrinh@utk.edu. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

An Instructors Guide to Water Pollution. Test Edition. AAAS Study Guides on Contemporary Problems, No. 5.

ERIC Educational Resources Information Center

Kidd, David E.

This is one of several study guides on contemporary problems produced by the American Association for the Advancement of Science with support of the National Science Foundation. This study guide on water pollution includes the following units: (1) Overview of World Pollution; (2) History, Definition, Criteria; (3) Ecosystem Theory; (4) Biological…

Aquaculture. Second Edition. Teacher Edition.

ERIC Educational Resources Information Center

Walker, Susan S.; Crummett, Dan

This teacher and student guide for aquaculture contains 15 units of instruction that cover the following topics: (1) introduction to aquaculture; (2) the aquatic environment; (3) fundamental fish biology; (4) marketing; (5) site selection; (6) facility design and layout; (7) water quality management; (8) fish health management; (9) commercial…

Graphic Design Career Guide 2. Revised Edition.

ERIC Educational Resources Information Center

Craig, James

The graphic design field is diverse and includes many areas of specialization. This guide introduces students to career opportunities in graphic design. The guide is organized in four parts. "Part One: Careers in Graphic Design" identifies and discusses the various segments of the graphic design industry, including: Advertising, Audio-Visual, Book…

New daily persistent headache: An evolving entity.

PubMed

Uniyal, Ravi; Paliwal, Vimal Kumar; Anand, Sucharita; Ambesh, Paurush

2018-01-01

New daily persistent headache (NDPH) is characterized by an abrupt onset of headache that becomes a daily entity, is unremitting and continuous from the onset, and lasts for more than 3 months. Dr Walter Vanast first described NDPH in the year 1986. Originally, it was proposed as a chronic daily headache but it was placed under "other primary headaches" in the International Classification of Headache Disorder Second Edition (ICHD 2nd edition). However, with evolving literature and better understanding of its clinical characteristics, it was classified as a "chronic daily headache" in the ICHD 3 rd edition beta. There are still many knowledge-gaps regarding the underlying cause, pathophysiology, natural history and treatment of NDPH. This review tries to revisit the entity and discusses the current status of understanding regarding NDPH.

Validity of proposed DSM-5 diagnostic criteria for nicotine use disorder: results from 734 Israeli lifetime smokers

PubMed Central

Shmulewitz, D.; Wall, M.M.; Aharonovich, E.; Spivak, B.; Weizman, A.; Frisch, A.; Grant, B. F.; Hasin, D.

2013-01-01

Background The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes aligning nicotine use disorder (NUD) criteria with those for other substances, by including the current DSM fourth edition (DSM-IV) nicotine dependence (ND) criteria, three abuse criteria (neglect roles, hazardous use, interpersonal problems) and craving. Although NUD criteria indicate one latent trait, evidence is lacking on: (1) validity of each criterion; (2) validity of the criteria as a set; (3) comparative validity between DSM-5 NUD and DSM-IV ND criterion sets; and (4) NUD prevalence. Method Nicotine criteria (DSM-IV ND, abuse and craving) and external validators (e.g. smoking soon after awakening, number of cigarettes per day) were assessed with a structured interview in 734 lifetime smokers from an Israeli household sample. Regression analysis evaluated the association between validators and each criterion. Receiver operating characteristic analysis assessed the association of the validators with the DSM-5 NUD set (number of criteria endorsed) and tested whether DSM-5 or DSM-IV provided the most discriminating criterion set. Changes in prevalence were examined. Results Each DSM-5 NUD criterion was significantly associated with the validators, with strength of associations similar across the criteria. As a set, DSM-5 criteria were significantly associated with the validators, were significantly more discriminating than DSM-IV ND criteria, and led to increased prevalence of binary NUD (two or more criteria) over ND. Conclusions All findings address previous concerns about the DSM-IV nicotine diagnosis and its criteria and support the proposed changes for DSM-5 NUD, which should result in improved diagnosis of nicotine disorders. PMID:23312475

Structural Validity of the Movement ABC-2 Test: Factor Structure Comparisons across Three Age Groups

ERIC Educational Resources Information Center

Schulz, Joerg; Henderson, Sheila E.; Sugden, David A.; Barnett, Anna L.

2011-01-01

Background: The Movement ABC test is one of the most widely used assessments in the field of Developmental Coordination Disorder (DCD). Improvements to the 2nd edition of the test (M-ABC-2) include an extension of the age range and reduction in the number of age bands as well as revision of tasks. The total test score provides a measure of motor…

Dynamic Terrin

DTIC Science & Technology

1991-12-30

York, 1985. [ Serway 86]: Raymond Serway , Physics for Scientists and Engineers. 2nd Edition, Saunders College Publishing, Philadelphia, 1986. pp. 200... Physical Modeling System 3.4 Realtime Hydrology 3.5 Soil Dynamics and Kinematics 4. Database Issues 4.1 Goals 4.2 Object Oriented Databases 4.3 Distributed...Animation System F. Constraints and Physical Modeling G. The PM Physical Modeling System H. Realtime Hydrology I. A Simplified Model of Soil Slumping

Validity of the Fine Motor Area of the 12-Month Ages and Stages Questionnaire in Infants Following Major Surgery

ERIC Educational Resources Information Center

Smith, Cally; Wallen, Margaret; Walker, Karen; Bundy, Anita; Rolinson, Rachel; Badawi, Nadia

2012-01-01

The Ages and Stages Questionnaires (ASQ) are parent-report screening tools to identify infants at risk of developmental difficulties. The purpose of this study was to examine validity and internal reliability of the fine motor developmental area of the ASQ, 2nd edition (ASQ2-FM) for screening 12-month-old infants following major surgery. The…

76 FR 74803 - Laboratory Animal Welfare: Adoption and Implementation of the Eighth Edition of the Guide for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Laboratory Animal Welfare: Adoption and Implementation of the Eighth Edition of the Guide for the Care and Use of Laboratory Animals... the Guide for the Care and Use of Laboratory Animals (Guide) and has determined to adopt the 8th...

A Practical Guide for Translators (Third Revised Edition). Topics in Translation 13.

ERIC Educational Resources Information Center

Samuelsson-Brown, Geoffrey

This third edition of a guide for translators contains more information than the second edition and looks at translation as a business as well as an occupation, focusing on marketing and quality control. It is designed for people with little or no practical experience with translation in a commercial environment. The 16 chapters examine these…

Food Production, Management and Services: Service. Teacher Edition. Second Edition.

ERIC Educational Resources Information Center

Palan, Earl

This food production, management, and services teacher guide contains nine units: (1) orientation; (2) types of service; (3) table settings; (4) dining room personnel; (5) dining room procedures; (6) side work; (7) guest/employee relationships; (8) sales techniques; and (9) safety and sanitation. Suggestions are included to increase reinforcement…

The International Handbook of Universities. Twenty-Second Edition

ERIC Educational Resources Information Center

Palgrave Macmillan, 2010

2010-01-01

The new "International Handbook of Universities" is now 2-volumes and includes single-user access to World Higher Education Database Online. This "Twenty-second Edition" is the most comprehensive guide to university-level education worldwide, providing detailed information on higher education institutions that offer at least a post-graduate degree…

Systematic Instruction of Functional Skills for Students and Adults with Disabilities. 2nd Edition

ERIC Educational Resources Information Center

Storey, Keith; Miner, Craig

2017-01-01

This book provides an overview of systematic instructional strategies and is written in a format so that teachers and other service providers can immediately put the information to use. It specifically focuses upon systematic instruction for individuals with disabilities (school age and adults) and is generic across age groups as well as…

The Principal as Instructional Leader: A Handbook for Supervisors. 2nd Edition

ERIC Educational Resources Information Center

Zepeda, Sally J.

2007-01-01

Very few people would disagree that the work of the principal is multifaceted, hectic, and fraught with uncertainties, and given the ongoing press for accountability, the very work of the principal as instructional leader is shifting to ensure "results." There are myriad day-to-day activities that take principals away from the important work of…

Healing Childhood Ear Infections: Prevention, Home Care, and Alternative Treatment. 2nd Edition.

ERIC Educational Resources Information Center

Schmidt, Michael A.

This book describes current controversy in medical journals over existing treatments for chronic childhood earaches. It suggests that the causes of otitis media are a series of events which flourish when poor nutrition occurs, noting that careful attention to diet and nutrition to prevent food allergies, and the use of acupressure, homeopathic…

Dare To Be You Program. Leaders' Manual. 2nd Edition.

ERIC Educational Resources Information Center

Miller-Heyl, Janet Lynne; Shores, Wanda, Ed.

This manual contains a complete set of program formats, activities, and references covered by the Dare to be You Training Program. The program, piloted in a rural Colorado County, is designed for use by parents, youth, teachers, church, and service organizations to help them deal with adolescents' problems and to assist youth in developing skills…

Agile Methods: Selected DoD Management and Acquisition Concerns

DTIC Science & Technology

2011-10-01

SIDRE Software Intensive Innovative Development and Reengineering/Evolution SLIM Software Lifecycle Management -Estimate SLOC source lines of code...ISBN #0321502752 Coaching Agile Teams Lyssa Adkins ISBN #0321637704 Agile Project Management : Creating Innovative Products – Second Edition Jim...Accessed July 13, 2011. [Highsmith 2009] Highsmith, J. Agile Project Management : Creating Innovative Products, 2nd ed. Addison- Wesley, 2009

Brain Matters: Translating Research into Classroom Practice. 2nd Edition

ERIC Educational Resources Information Center

Wolfe, Patricia

2010-01-01

While you don't need to be a scientist to understand brain-compatible teaching, you'll be far more effective when you base your teaching practices on the very best scientific information. This expanded and updated ASCD best-seller delivers that essential information in clear, everyday language that any teacher can immediately incorporate into…

Research in Applied Linguistics: Becoming a Discerning Consumer, 2nd Edition

ERIC Educational Resources Information Center

Perry, Fred L., Jr.

2011-01-01

Newly updated and revised, this popular text provides a solid introduction to the foundations of research methods, with the goal of enabling students and professionals in the field of applied linguistics to become not just casual consumers of research who passively read bits and pieces of a research article, but "discerning" consumers able to…

Being Smart about Gifted Education: A Guidebook for Parents and Educators (2nd Edition)

ERIC Educational Resources Information Center

Matthews, Dona J.; Foster, Joanne F.

2009-01-01

Written for both parents and educators who work with children of advanced abilities, the authors present practical strategies to identify and nurture exceptionally high ability in children. They promote the "mastery" (rather than the "mystery") model of gifted education, and challenge several common practices and assumptions. They offer ways to…

The Science of Learning. 2nd Edition

ERIC Educational Resources Information Center

Pear, Joseph J.

2016-01-01

For over a century and a quarter, the science of learning has expanded at an increasing rate and has achieved the status of a mature science. It has developed powerful methodologies and applications. The rise of this science has been so swift that other learning texts often overlook the fact that, like other mature sciences, the science of…

The Pitch: How To Analyze Ads. 2nd Edition.

ERIC Educational Resources Information Center

Rank, Hugh

This book probes the ways ads persuade people to purchase, and attempts to teach individuals to become more discerning consumers. Critical thinking, when applied to analyzing ads, benefits consumers by helping them recognize patterns of persuasion and sort incoming information in order to get to the hidden message. The book s basic premise is that…

Advanced Beef Unit for Advanced Livestock Production Curriculum. Selected Readings. AGDEX 420/00.

ERIC Educational Resources Information Center

Sparks, Jim; Stewart, Bob R.

These selected readings are designed to supplement James Gillespie's "Modern Livestock and Poultry Production" (2nd edition) as the student reference for the advanced beef unit. The 15 lessons build on Agricultural Science I and II competencies. Topics of the 15 lessons are: importance of the beef enterprise; cost of beef production;…

Handbook of Research on the Education of Young Children. 2nd Edition

ERIC Educational Resources Information Center

Spodek, Bernard, Ed.; Saracho, Olivia N., Ed.

2006-01-01

This book is an essential reference on research in early childhood education not only in the United States but throughout the world. It provides a comprehensive overview of important contemporary issues and the information necessary to make judgments about these issues. The field has changed significantly since the publication of the first edition…

Behavior Management Strategies for Teachers: Achieving Instructional Effectiveness, Student Success, and Student Motivation--Every Teacher and Any Student Can! 2nd Edition.

ERIC Educational Resources Information Center

Harlan, Joan C.; Rowland, Sidney T.

This book provides tested methods for teachers to use in their behavior management and instructional efforts, offering strategies for maintaining and increasing appropriate behaviors as well as preventing and remediating inappropriate behaviors. Section 1, "Understanding Behavior and Selected Models," includes (1) "Understanding…

Community Renewal. Experiences from the Field. An Adult Educator's Resource Kit. 2nd Edition.

ERIC Educational Resources Information Center

Le Baron, Beth; And Others

This kit suggests ideas and resources for adult educators and other community workers to use in assisting individuals, groups, and communities to respond effectively to a changing economy. Introductory materials provide the purpose, a note on content arrangement, and suggestions for program methods and program planning. The main portion of the kit…

Test Review: March, J. S. (2013), "Multidimensional Anxiety Scale for Children-2nd Edition." Toronto, Ontario, Canada: Multi-Health Systems

ERIC Educational Resources Information Center

Fraccaro, Rebecca L.; Stelnicki, Andrea M.; Nordstokke, David W.

2015-01-01

Anxiety disorders are among the most prevalent mental disorders among school-age children and can lead to impaired academic and social functioning (Keeley & Storch, 2009). Unfortunately, anxiety disorders in this population are often undetected (Herzig-Anderson, Colognori, Fox, Stewart, & Warner, 2012). The availability of psychometrically…

Jean-Jacques Rousseau on Adult Education and Revolution. Paradigma of Radical, Pedagogical Thought. 2nd Revised Edition.

ERIC Educational Resources Information Center

Dame, Frederick William

This book explores Jean-Jacques Rousseau's educational philosophy, as expressed in his key works, and applies that philosophy to adult education and revolution. The titles and topics of the book's seven chapters are as follows: (1) "L'Invitation: Raison d'Etre" (prelude, statement, significance, the process, assumptions and limitations);…

Validity and Reliability of the Arabic Token Test for Children

ERIC Educational Resources Information Center

Alkhamra, Rana A.; Al-Jazi, Aya B.

2016-01-01

Background: The Token Test for Children (2nd edition) (TTFC) is a measure for assessing receptive language. In this study we describe the translation process, validity and reliability of the Arabic Token Test for Children (A-TTFC). Aims: The aim of this study is to translate, validate and establish the reliability of the Arabic Token Test for…

Assessing Children for the Presence of a Disability. Resources You Can Use. NICHCY Bibliography. 2nd Edition.

ERIC Educational Resources Information Center

Gutierrez, Mary Kate, Comp.

This resource list is intended to provide school systems with information on assessment of school-aged children for the presence of a disability. The 104 references are broken down into the following categories: general assessment information; assessment tools; critiques of assessment tools; curriculum-based assessment; assessments of different…

Access to Vocational Training in Three Sectors of the European Economy. Comparative Analysis. 2nd Edition. CEDEFOP Panorama.

ERIC Educational Resources Information Center

Lassibille, Gerard; Paul, Jean-Jacques

This report presents findings of a study of the theoretical and practical methods of access to continuing vocational training. It summarizes six reports that compare the following: the construction sector in Spain, France, Italy, and Luxembourg; the banking, insurance, commerce, and administration sectors in Germany, Ireland, the Netherlands, and…

Kerala: Radical Reform As Development in an Indian State. 2nd Edition.

ERIC Educational Resources Information Center

Franke, Richard W.; Chasin, Barbara H.

Kerala, a state in southwestern India, has implemented radical reform as a development strategy. As a result, Kerala now has some of the Third World's highest levels of health, education, and social justice. Originally published in 1989, this book traces the role that movements of social justice played in Kerala's successful struggle to…

Background Readings in American Education.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC. Bureau of Research.

This collection of readings was assembled and edited for use at the White House Conference on Education in Washington, D.C. on July 21st and 22nd, 1965. Some of the twenty-nine documents of historical value and relevance in today's educational milieu are: 1) Proposals Relating to the Education of Youth in Pennsylvania, Benjamin Franklin, 1749; 2)…

Sorbian: The Sorbian Language in Education in Germany, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Brezan, Beate, Comp.; Nowak, Meto, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Swedish: The Swedish Language in Education in Finland, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Østern, Anna-Lena, Comp.; Harju-Luukkainen, Heidi, Comp.

2013-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Ladin: The Ladin Language in Education in Italy, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Verra, Roland, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Galician: The Galician Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Costas, Xosé-Henrique, Comp.; Expósito-Loureiro, Andrea, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Welsh: The Welsh Language in Education in the UK, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Jones, Meirion Prys, Comp.; Jones, Ceinwen, Comp.

2014-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Irish: The Irish Language in Education in the Republic of Ireland, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Ó Murchú, Helen, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Asturian: The Asturian Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

González-Riaño, Xosé Antón, Comp.; Fernández-Costales, Alberto, Comp.

2014-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

ACR Electrical Systems. Teacher Edition [and] Student Edition.

ERIC Educational Resources Information Center

Clemons, Mark

This document contains a teacher's guide and student guide for a high school-level competency-based course in air conditioning and refrigeration (ACR) equipment electrical systems. Presented in the teacher's guide are the following: explanation of the instructional units' use; competency profile for recording students' performance of the tasks in…

Test Review: Wagner, R. K., Torgesen, J. K., Rashotte, C. A., & Pearson, N. A., "Comprehensive Test of Phonological Processing-2nd Ed. (CTOPP-2)." Austin, Texas: Pro-Ed

ERIC Educational Resources Information Center

Dickens, Rachel H.; Meisinger, Elizabeth B.; Tarar, Jessica M.

2015-01-01

The Comprehensive Test of Phonological Processing-Second Edition (CTOPP-2; Wagner, Torgesen, Rashotte, & Pearson, 2013) is a norm-referenced test that measures phonological processing skills related to reading for individuals aged 4 to 24. According to its authors, the CTOPP-2 may be used to identify individuals who are markedly below their…

Test Review: E. Schopler, M. E. Van Bourgondien, G. J. Wellman, & S. R. Love "Childhood Autism Rating Scale" (2nd Ed.). Los Angeles, CA--Western Psychological Services, 2010

ERIC Educational Resources Information Center

Vaughan, Chelsea A.

2011-01-01

The author reviews Childhood Autism Rating Scale-Second Edition (CARS2), a useful tool for supporting the diagnostic process and for forming intervention recommendations once a diagnosis has been made. CARS2 consists of three rating forms designed to identify symptoms associated with autism spectrum disorders (ASD). Published in 2010, the CARS2…

Motor Testing at 1 Year Improves the Prediction of Motor and Mental Outcome at 2 Years after Perinatal Hypoxic-Ischaemic Encephalopathy

ERIC Educational Resources Information Center

van Schie, Petra Em; Becher, Jules G.; Dallmeijer, Annet J.; Barkhof, Frederik; van Weissenbruch, Mirjam M.; Vermeulen, R. Jeroen

2010-01-01

Aim: To investigate the predictive value of motor testing at 1 year for motor and mental outcome at 2 years after perinatal hypoxic-ischaemic encephalopathy (HIE) in term neonates. Method: Motor and mental outcome at 2 years was assessed with the Bayley Scales of Infant Development, 2nd edition (BSID-II) in 32 surviving children (20 males, 12…

Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.

PubMed

Duty, J Andrew; Szodoray, Peter; Zheng, Nai-Ying; Koelsch, Kristi A; Zhang, Qingzhao; Swiatkowski, Mike; Mathias, Melissa; Garman, Lori; Helms, Christina; Nakken, Britt; Smith, Kenneth; Farris, A Darise; Wilson, Patrick C

2009-01-16

Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface IgM and retaining only IgD are autoreactive and functionally attenuated (referred to as naive IgD(+)IgM(-) B cells [B(ND)]). These B(ND) cells typically make up 2.5% of B cells in the peripheral blood, have antibody variable region genes in germline (unmutated) configuration, and, by all current measures, are fully mature. Analysis of 95 recombinant antibodies expressed from the variable genes of single B(ND) cells demonstrated that they are predominantly autoreactive, binding to HEp-2 cell antigens and DNA. Upon B cell receptor cross-linkage, B(ND) cells have a reduced capacity to mobilize intracellular calcium or phosphorylate tyrosines, demonstrating that they are anergic. However, intense stimulation causes B(ND) cells to fully respond, suggesting that these cells could be the precursors of autoantibody secreting plasma cells in autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis. This is the first identification of a distinct mature human B cell subset that is naturally autoreactive and controlled by the tolerizing mechanism of functional anergy.

CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration.

PubMed

Koo, Taeyoung; Park, Sung Wook; Jo, Dong Hyun; Kim, Daesik; Kim, Jin Hyoung; Cho, Hee-Yeon; Kim, Jeungeun; Kim, Jeong Hun; Kim, Jin-Soo

2018-05-10

LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular degeneration (AMD). The intravitreal delivery of LbCpf1, targeted to two angiogenesis-associated genes encoding vascular endothelial growth factor A (Vegfa) and hypoxia inducing factor 1a (Hif1a), using adeno-associated virus, led to efficient gene disruption with no apparent off-target effects in the retina and retinal pigment epithelium (RPE) cells. Importantly, LbCpf1 targeted to Vegfa or Hif1a in RPE cells reduced the area of laser-induced choroidal neovascularization as efficiently as aflibercept, an anti-VEGF drug currently used in the clinic, without inducing cone dysfunction. Unlike aflibercept, LbCpf1 targeted to Vegfa or Hif1a achieved a long-term therapeutic effect on CNV, potentially avoiding repetitive injections. Taken together, these results indicate that LbCpf1-mediated in vivo genome editing to ablate pathologic angiogenesis provides an effective strategy for the treatment of AMD and other neovascularization-associated diseases.

Impairment Rating Ambiguity in the United States: The Utah Impairment Guides for Calculating Workers' Compensation Impairments

PubMed Central

Hunter, Bradley; Bunkall, Larry D.; Holmes, Edward B.

2009-01-01

Since the implementation of workers' compensation, accurately and consistently rating impairment has been a concern for the employee and employer, as well as rating physicians. In an attempt to standardize and classify impairments, the American Medical Association (AMA) publishes the AMA Guides ("Guides"), and recently published its 6th edition of the AMA Guides. Common critiques of the AMA Guides 6th edition are that they are too complex, lacking in evidence-based methods, and rarely yield consistent ratings. Many states mandate use of some edition of the AMA Guides, but few states are adopting the current edition due to the increasing difficulty and frustration with their implementation. A clearer, simpler approach is needed. Some states have begun to develop their own supplemental guides to combat problems in complexity and validity. Likewise studies in Korea show that past methods for rating impairment are outdated and inconsistent, and call for measures to adapt current methods to Korea's specific needs. The Utah Supplemental Guides to the AMA Guides have been effective in increasing consistency in rating impairment. It is estimated that litigation of permanent impairment has fallen below 1% and Utah is now one of the least costly states for obtaining workers' compensation insurance, while maintaining a medical fee schedule above the national average. Utah's guides serve as a model for national or international impairment guides. PMID:19503678

Banking and Financial Systems. Curriculum Guide. First Edition.

ERIC Educational Resources Information Center

Patton, Jan

This curriculum guide provides course materials for teachers to use in developing a course in banking and financial systems. Following an introductory section that lists the common essential elements of the course, the guide contains six sections that cover the following course topics: (1) introduction to banking and financial systems; (2) banking…

Resource Guide on Smoking and Health for Canadian Schools. Second Edition.

ERIC Educational Resources Information Center

Department of National Health and Welfare, Ottawa (Ontario).

In addition to an overview of smoking and health, this resource guide provides (1) lesson guidelines focusing specifically on physical, social and economic, and psychological factors involved with smoking; (2) examples of simple experiments and demonstrations; (3) a guide to films, filmstrips, slides, and printed materials on smoking and health;…

Florida's Manatee. An Educator's Guide. Third Edition Revised.

ERIC Educational Resources Information Center

Fritz-Quincy, Debbie

This revised and updated guide provides resources for teaching about the Florida manatee, a nearly hairless, thick-skinned marine mammal without hindlimbs and with paddle-like forelimbs. The manatee (an endangered species) is sometimes called a sea cow. The guide includes: (1) a vocabulary list; (2) a list of suggested readings; (3) an annotated…

Factorial Validity of the Movement Assessment Battery for Children-2nd Edition (MABC-2) in 7-16-Year-Olds.

PubMed

Psotta, Rudolf; Abdollahipour, Reza

2017-12-01

The Movement Assessment Battery for Children-2nd Edition (MABC-2) is a test of motor development, widely used in clinical and research settings. To address which motor abilities are actually captured by the motor tasks in the two age versions of the MABC-2, the AB2 for 7- 10-year-olds and the AB3 for 11- 16-year-olds, we examined AB2 and AB3 factorial validity. We conducted confirmatory factor analysis (SPSS AMOS 22.0) on data from the test's standardization samples of children aged 7-10, n = 483, and 11-16, n = 674, in order to find the best fitting models. The covariance matrix of AB2 and AB3 fit a three-factor model that included tasks of manual dexterity, aiming and catching, and balance. However, factor analytic models fitting AB2 and AB3 did not involve the dynamic balance tasks of hopping with the better leg and hopping with the other leg; and the drawing trail showed very low factor validity. In sum, both AB2 and AB3 of the MABC-2 test are able to discriminate between the three specific motor abilities; but due to questionable psychometric quality, the drawing trail and hopping tasks should be modified to improve the construct validity for both age versions of the MABC-2.

Asia: A Guide to Paperbacks. Revised Edition.

ERIC Educational Resources Information Center

Embree, Ainslie T., Ed.

The guide includes in-print titles which were listed in the original guide and the supplement, new titles which appeared between December 1965 and December 1967, books published in 1968 provided by some publishers, and a few titles omitted from earlier editions. All the books are listed alphabetically by author within five subject areas:…

ASIA A Guide to Paperbacks. Revised Edition.

ERIC Educational Resources Information Center

Embree, Ainslie T., Ed.

The guide includes in-print titles which were listed in the original guide and the supplement, new titles which appeared between December 1965 and December 1967, books published in 1968 provided by some publishers, and a few titles omitted from earlier editions. All the books are listed alphabetically by author within five subject areas:…

Health Education Teaching Ideas: Secondary. Revised Edition.

ERIC Educational Resources Information Center

Loya, Richard, Ed.; Bensley, Loren B., Jr., Ed.

Part I of this teaching guide contains teaching strategies which originally appeared in the "Journal of Health Education" (JHE) and were included in the first edition of this guide, published in 1983. Part II includes teaching strategies published in JHE since 1983. The guide is designed to be a reference for those seeking workable ideas in…

Contributions to Integral Nuclear Data in ICSBEP and IRPhEP since ND 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bess, John D.; Briggs, J. Blair; Gulliford, Jim

2016-09-01

The status of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and the International Reactor Physics Experiment Evaluation Project (IRPhEP) was last discussed directly with the international nuclear data community at ND2013. Since ND2013, integral benchmark data that are available for nuclear data testing has continued to increase. The status of the international benchmark efforts and the latest contributions to integral nuclear data for testing is discussed. Select benchmark configurations that have been added to the ICSBEP and IRPhEP Handbooks since ND2013 are highlighted. The 2015 edition of the ICSBEP Handbook now contains 567 evaluations with benchmark specifications for 4,874more » critical, near-critical, or subcritical configurations, 31 criticality alarm placement/shielding configuration with multiple dose points apiece, and 207 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications. The 2015 edition of the IRPhEP Handbook contains data from 143 different experimental series that were performed at 50 different nuclear facilities. Currently 139 of the 143 evaluations are published as approved benchmarks with the remaining four evaluations published in draft format only. Measurements found in the IRPhEP Handbook include criticality, buckling and extrapolation length, spectral characteristics, reactivity effects, reactivity coefficients, kinetics, reaction-rate distributions, power distributions, isotopic compositions, and/or other miscellaneous types of measurements for various types of reactor systems. Annual technical review meetings for both projects were held in April 2016; additional approved benchmark evaluations will be included in the 2016 editions of these handbooks.« less

Wound, Ostomy, and Continence Nursing: Scope and Standards of Practice, 2nd Edition: An Executive Summary.

PubMed

2018-04-25

Wound, ostomy, and continence (WOC) nursing was recognized as a nursing specialty by the American Nurses Association in February 2010, and the Society published the original scope and standards of WOC nursing practice in May 2010. The Wound, Ostomy, and Continence Nursing: Scope and Standards of Practice, 2nd Edition is the definitive resource promoting excellence in professional practice, quality care, and improved patient outcomes in WOC specialty practice. It can be used to articulate the value of WOC nurses to administrators, legislators, payers, patients, and others. The second edition also provides an overview of the scope of WOC nursing practice including a description of the specialty, the history and evolution of WOC nursing, characteristics of WOC nursing practice, and description of the trispecialty. The document describes various WOC nurse roles, populations served, practice settings, care coordination, and collaboration. Educational preparation, levels of practice within WOC specialty nursing, certification, mandate for continuous professional development, ethics, current trends, future considerations and challenges, and standards of WOC nursing practice and professional performance with competencies for each standard are provided. The purpose of this Executive Summary is to describe the process for developing the scope and standards document, provide an overview of the scope of WOC nursing practice, and list the standards of practice and professional performance along with the competencies for each level of WOC nurse provider. The original document is available from the WOCN Society's online book store (www.wocn.org).

Far infrared supplement: Catalog of infrared observations, second edition

NASA Technical Reports Server (NTRS)

Gezari, Daniel Y.; Schmitz, Marion; Mead, Jaylee M.

1988-01-01

The Far Infrared Supplement: Catalog of Infrared Observations summarizes all infrared astronomical observations at far infrared wavelengths (5 to 1000 microns) published in the scientific literature from 1965 through 1986. The Supplement list contain 25 percent of the observations in the full Catalog of Infrared Observations (CIO), and essentially eliminates most visible stars from the listings. The Supplement is thus more compact than the main catalog, and is intended for easy reference during astronomical observations. The Far Infrared Supplement (2nd Edition) includes the Index of Infrared Source Positions and the Bibliography of Infrared Astronomy for the subset of far infrared observations listed.

Using XML/HTTP to Store, Serve and Annotate Tactical Scenarios for X3D Operational Visualization and Anti-Terrorist Training

DTIC Science & Technology

2003-03-01

PXSLServlet Paul A. Open Source Relational x X 23 Tchistopolskii sql2dtd David Mertz Public domain Relational x -- sql2xml Scott Hathaway Public...March 2003. [Hunter 2001] Hunter, David ; Cagle, Kurt; Dix, Chris; Kovack, Roger; Pinnock, Jonathan, Rafter, Jeff; Beginning XML (2nd Edition...Postgraduate School Monterey, California 4. Curt Blais Naval Postgraduate School Monterey, California 5 Erik Chaum NAVSEA Undersea

No evidence of genome editing activity from Natronobacterium gregoryi Argonaute (NgAgo) in human cells.

PubMed

Javidi-Parsijani, Parisa; Niu, Guoguang; Davis, Meghan; Lu, Pin; Atala, Anthony; Lu, Baisong

2017-01-01

The argonaute protein from the thermophilic bacterium Thermus thermophilus shows DNA-guided DNA interfering activity at high temperatures, complicating its application in mammalian cells. A recent work reported that the argonaute protein from Natronobacterium gregoryi (NgAgo) had DNA-guided genome editing activity in mammalian cells. We compared the genome editing activities of NgAgo and Staphylococcus aureus Cas9 (SaCas9) in human HEK293T cells side by side. EGFP reporter assays and DNA sequencing consistently revealed high genome editing activity from SaCas9. However, these assays did not demonstrate genome editing activity by NgAgo. We confirmed that the conditions allowed simultaneous transfection of the NgAgo expressing plasmid DNA and DNA guides, as well as heterologous expression of NgAgo in the HEK293T cells. Our data show that NgAgo is not a robust genome editing tool, although it may have such activity under other conditions.

Instruments for the nondestructive testing of materials and products: Handbook. Volumes 1 & 2 (2nd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Kliuev, V. V.

Data on the general design and principles of operation of various instruments and systems for the nondestructive testing of materials and products of various kinds are presented, and test procedures are described. Methods discussed include optical, thermal, capillary, RF, and X-ray testing techniques. The discussion also covers magnetic, electromagnetic, eddy-current, acoustic, and combined nondestructive testing methods.

Funding Sources for Community and Economic Development 1997: A Guide to Current Sources for Local Programs and Projects. Third Edition.

ERIC Educational Resources Information Center

1997

This guide contains information on 2,086 funding programs that provide support on national, state, and local levels for economic and community development, social services, and the humanities. The guide begins with "A Guide to Proposal Planning and Writing" (Lynn E. Miner), which includes strategies for locating information on public and private…

Adult Education and Social Responsibility: Reconciling the Irreconcilable? 2nd Revised Edition. Studies in Pedagogy, Andragogy and Gerontagogy, Vol. 36.

ERIC Educational Resources Information Center

Wildemeersch, Danny, Ed.; Finger, Matthias, Ed.; Jansen, Theo, Ed.

In this book, 16 authors from Europe, Africa, and the United States reflect on the transformations that are currently taking place in the field of adult and continuing education. The 12 chapters are "Reconciling the Irreconcilable? Adult and Continuing Education Between Personal Development, Corporate Concerns, and Public Responsibility"…

The Army’s Armored Multi-Purpose Vehicle (AMPV): Background and Issues for Congress

DTIC Science & Technology

2013-09-24

Christopher F. Foss, Jane’s Armour and Artillery, 2011-2012, 32nd Edition, pp. 470-478. 2 Tony Bertuca, “Optimism Emerges for the AMPV Program, Though Pre...for 29 EMD prototypes for testing between 2014 and 2017 and $1.08 billion for 289 low-rate initial production (LRIP) models between 2018 and 2020. The

Disease Vector Ecology Profile: Yugoslav Republics. 2nd Edition

DTIC Science & Technology

1993-10-27

potatoes, grapes, barley, hogs, sheep , cattle, poultry). Mineral resources include: copper, iron, lead, zinc, bauxite, antimony, and manganese. Primary...Encephalitis, Biphasic Meningoencephalitis, Diphasic Milk Fever, (abbreviation TBE). INFECTIOUS AGENT: Arbovirus, Flavivirus, family Flaviviridae, Russian Spring...OF TRANSMISSION: Occurs through the bite of an infective tick or through the consumption of raw and unpasteurized milk and milk products (e.g. goat

What Every Patient, Family, Friend, and Caregiver Needs To Know about Psychiatry. 2nd Edition.

ERIC Educational Resources Information Center

Roukema, Richard W.

This book is written in a simple, concise style for the layperson--and is packed with need-to-know information on adult psychiatric disorders, including their causes, approaches to treatment, and what caregivers can do to help. The book is promoted as an excellent text for introduction to psychiatry classes in colleges and nursing schools for…

Learning and Teaching Early Math: The Learning Trajectories Approach, 2nd Edition. Studies in Mathematical Thinking and Learning Series

ERIC Educational Resources Information Center

Clements, Douglas H.; Sarama, Julie

2014-01-01

In this important book for pre- and in-service teachers, early math experts Douglas Clements and Julie Sarama show how "learning trajectories" help diagnose a child's level of mathematical understanding and provide guidance for teaching. By focusing on the inherent delight and curiosity behind young children's mathematical reasoning,…

The Beck Depression Inventory II and the Beck Anxiety Inventory in People with Intellectual Disabilities: Factor Analyses and Group Data

ERIC Educational Resources Information Center

Lindsay, William R.; Skene, Danielle D.

2007-01-01

Background: There have been several developments in research on emotional disorders in people with intellectual disability (ID). Although a large amount of work has been completed in mainstream clinical fields on the "Beck Anxiety Inventory" (BAI) and the "Beck Depression Inventory"-2nd Edition (BDI-II), to date there has been…

SARA Reading Components Tests, RISE Forms: Technical Adequacy and Test Design, 2nd Edition. Research Report. ETS RR-15-32

ERIC Educational Resources Information Center

Sabatini, John; Bruce, Kelly; Steinberg, Jonathan; Weeks, Jonathan

2015-01-01

This technical report describes the conceptual foundation and measurement properties of the Reading Inventory and Scholastic Evaluation (RISE). The RISE is a 6-subtest, Web-administered reading skills components battery. The theoretical and empirical foundations of each subtest in the battery are reviewed, as well as item designs. The results…

Digital avionics systems - Principles and practices (2nd revised and enlarged edition)

NASA Technical Reports Server (NTRS)

Spitzer, Cary R.

1993-01-01

The state of the art in digital avionics systems is surveyed. The general topics addressed include: establishing avionics system requirements; avionics systems essentials in data bases, crew interfaces, and power; fault tolerance, maintainability, and reliability; architectures; packaging and fitting the system into the aircraft; hardware assessment and validation; software design, assessment, and validation; determining the costs of avionics.

A Typology of Teacher-Rated Child Behavior: Revisiting Subgroups over 10 Years Later

ERIC Educational Resources Information Center

DiStefano, Christine A.; Kamphaus, Randy W.; Mindrila, Diana L.

2010-01-01

The purpose of this article was to examine a typology of child behavior using the Behavioral Assessment System for Children, Teacher Rating Scale (BASC TRS-C, 2nd edition; Reynolds & Kamphaus, 2004). The typology was compared with the solution identified from the 1992 BASC TRS-C norm dataset. Using cluster analysis, a seven-cluster solution…

Iranian Language Teachers' and Students' Perspectives on Top Notch Series (2nd Edition) at Intermediate Level

ERIC Educational Resources Information Center

Azadsarv, Mehdi; Tahriri, Abdorreza

2014-01-01

As the means of transferring knowledge between teachers and students, coursebooks play a significant role in educational practices all over the world. Evaluation of coursebooks is also of great significance as it manages to a better understanding of the nature of a specific teaching/learning situation. The present study is an attempt to evaluate…

Exploring Preschoolers' Engagement and Perceived Physical Competence in an Autonomy-Based Object Control Skill Intervention: A Preliminary Study

ERIC Educational Resources Information Center

Logan, Samuel; Robinson, Leah; Webster, E. Kipling; Barber, Laura

2013-01-01

The purpose of this study was to describe children's engagement during two (high and low) autonomy-based climates. Twenty-five preschool children participated in a nine-week object control skill intervention. Children completed the object control subscale of the Test of Gross Motor Development 2nd Edition and the perceived physical competence…

Place as Text: Approaches to Active Learning. 2nd Edition. National Collegiate Honors Council Monograph Series

ERIC Educational Resources Information Center

Braid, Bernice, Ed.; Long, Ada, Ed.

2010-01-01

The decade since publication of "Place as Text: Approaches to Active Learning" has seen an explosion of interest and productivity in the field of experiential education. This monograph presents a story of an experiment and a blueprint of sorts for anyone interested in enriching an existing program or willing to experiment with pedagogy…

Understanding the Gap between Cognitive Abilities and Daily Living Skills in Adolescents with Autism Spectrum Disorders with Average Intelligence

ERIC Educational Resources Information Center

Duncan, Amie W.; Bishop, Somer L.

2015-01-01

Daily living skills standard scores on the Vineland Adaptive Behavior Scales-2nd edition were examined in 417 adolescents from the Simons Simplex Collection. All participants had at least average intelligence and a diagnosis of autism spectrum disorder. Descriptive statistics and binary logistic regressions were used to examine the prevalence and…

The Overhead System: Production, Implementation and Utilization. 2nd Edition.

ERIC Educational Resources Information Center

Smith, Richard E.; Pearson, Jerry D.

This handbook is designed to help three groups: the administrator who does not have the services of a media specialist, the media specialist who wishes to expand his knowledge or skills, and the classroom teacher who recognizes the value of the overhead as a teaching tool and is looking for practical assistance. Guidelines are provided in 11…

Ability and Metacognitive Determinants of Skill Acquisition and Transfer

DTIC Science & Technology

1990-06-30

Encyclopedia of Artificial Intelligence . Volume 1, 2nd Edition. New York: Wiley. (Revision and expansion of Ackerman, 1987.) Ackerman, P. L. (Ed.) (In press...performance attributable to individual differences in level of cognitive ability/ intelligence . In addition, there must be a correspondence between...processing: An investigation of intellectual abilities and task performance during practice. Intelligence , 10, 109- 139. Ackerman, P. L. (1987

The Play's the Thing: Teachers' Roles in Children's Play. Early Childhood Education Series. 2nd Edition

ERIC Educational Resources Information Center

Jones, Elizabeth; Reynolds, Gretchen

2011-01-01

Responding to current debates on the place of play in schools, the authors have extensively revised their groundbreaking book. They explain how and why play is a critical part of children's development, as well as the central role adults have to promote it. This classic textbook and popular practitioner resource offers systematic descriptions and…

Technical Report of Research Studies Related to the Revolving Door Identification Model. 2nd Edition and Addendum. Research Report Series.

ERIC Educational Resources Information Center

Renzulli, Joseph S., Ed.

Six studies are presented which investigate factors in implementing the Revolving Door Identification Model (RDIM) and the Enrichment Triad Model in gifted education for children in grades 1-8. In "An Analysis of the Productivity of Gifted Students Participating in Programs Using the Revolving Door Identification Model," S. Reis reports,…

The Use of Authentic Assessment to Report Accountability Data on Young Children's Language, Literacy and Pre-Math Competency

ERIC Educational Resources Information Center

Gao, Xin; Grisham-Brown, Jennifer

2011-01-01

This validity study examined the validity of Assessment, Evaluation, and Programming System, 2nd Edition (AEPS®), a curriculum-based, authentic assessment for infants and young children. The primary purposes were to: a) examine whether the AEPS® is a concurrently valid tool for measuring young children's language, literacy and pre-math skills for…

School Library Automation in Australia: Issues and Results of the National Surveys. 2nd Edition. Topics in Australian Teacher Librarianship, No. 1.

ERIC Educational Resources Information Center

Dillon, Ken, Ed.

This publication about school library automation in Australia contains 18 chapters divided into seven sections. The chapters in the first section presents survey results: "School Library Automation in Australia: Results of the First, Second and Third National Surveys" (Ken Dillon); and "School Library Automation in New Zealand:…

Getting the Books Off the Shelves. Making the Most of Your Congregation's Library. Second Revised Edition. CSLA Guide No. 12.

ERIC Educational Resources Information Center

Smith, Ruth S.

This second revised edition of a guide to promoting and attracting users to a church library retains most of the material of the previous edition, adds new material, and updates the references. Guidelines are presented in six chapters: (1) "Promoting Library Use" (stages of promotion, ways of attracting the attention and interest of prospective…

Particle Physics, 2nd Edition

NASA Astrophysics Data System (ADS)

Martin, B. R.; Shaw, G.

1998-01-01

Particle Physics, Second Edition is a concise and lucid account of the fundamental constituents of matter. The standard model of particle physics is developed carefully and systematically, without heavy mathematical formalism, to make this stimulating subject accessible to undergraduate students. Throughout, the emphasis is on the interpretation of experimental data in terms of the basic properties of quarks and leptons, and extensive use is made of symmetry principles and Feynman diagrams, which are introduced early in the book. The Second Edition brings the book fully up to date, including the discovery of the top quark and the search for the Higgs boson. A final short chapter is devoted to the continuing search for new physics beyond the standard model. Particle Physics, Second Edition features: * A carefully structured and written text to help students understand this exciting and demanding subject. * Many worked examples and problems to aid student learning. Hints for solving the problems are given in an Appendix. * Optional "starred" sections and appendices, containing more specialised and advanced material for the more ambitious reader.

TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites.

PubMed

Ammerman, Michelle L; Presnyak, Vladimir; Fisk, John C; Foda, Bardees M; Read, Laurie K

2010-11-01

TbRGG2 is an essential kinetoplastid RNA editing accessory factor that acts specifically on pan-edited RNAs. To understand the mechanism of TbRGG2 action, we undertook an in-depth analysis of edited RNA populations in TbRGG2 knockdown cells and an in vitro examination of the biochemical activities of the protein. We demonstrate that TbRGG2 down-regulation more severely impacts editing at the 5' ends of pan-edited RNAs than at their 3' ends. The initiation of editing is reduced to some extent in TbRGG2 knockdown cells. In addition, TbRGG2 plays a post-initiation role as editing becomes stalled in TbRGG2-depleted cells, resulting in an overall decrease in the 3' to 5' progression of editing. Detailed analyses of edited RNAs from wild-type and TbRGG2-depleted cells reveal that TbRGG2 facilitates progression of editing past intrinsic pause sites that often correspond to the 3' ends of cognate guide RNAs (gRNAs). In addition, noncanonically edited junction regions are either absent or significantly shortened in TbRGG2-depleted cells, consistent with impaired gRNA transitions. Sequence analysis further suggests that TbRGG2 facilitates complete utilization of certain gRNAs. In vitro RNA annealing and in vivo RNA unwinding assays demonstrate that TbRGG2 can modulate RNA-RNA interactions. Collectively, these data are consistent with a model in which TbRGG2 facilitates initiation and 3' to 5' progression of editing through its ability to affect gRNA utilization, both during the transition between specific gRNAs and during usage of certain gRNAs.

TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites

PubMed Central

Ammerman, Michelle L.; Presnyak, Vladimir; Fisk, John C.; Foda, Bardees M.; Read, Laurie K.

2010-01-01

TbRGG2 is an essential kinetoplastid RNA editing accessory factor that acts specifically on pan-edited RNAs. To understand the mechanism of TbRGG2 action, we undertook an in-depth analysis of edited RNA populations in TbRGG2 knockdown cells and an in vitro examination of the biochemical activities of the protein. We demonstrate that TbRGG2 down-regulation more severely impacts editing at the 5′ ends of pan-edited RNAs than at their 3′ ends. The initiation of editing is reduced to some extent in TbRGG2 knockdown cells. In addition, TbRGG2 plays a post-initiation role as editing becomes stalled in TbRGG2-depleted cells, resulting in an overall decrease in the 3′ to 5′ progression of editing. Detailed analyses of edited RNAs from wild-type and TbRGG2-depleted cells reveal that TbRGG2 facilitates progression of editing past intrinsic pause sites that often correspond to the 3′ ends of cognate guide RNAs (gRNAs). In addition, noncanonically edited junction regions are either absent or significantly shortened in TbRGG2-depleted cells, consistent with impaired gRNA transitions. Sequence analysis further suggests that TbRGG2 facilitates complete utilization of certain gRNAs. In vitro RNA annealing and in vivo RNA unwinding assays demonstrate that TbRGG2 can modulate RNA–RNA interactions. Collectively, these data are consistent with a model in which TbRGG2 facilitates initiation and 3′ to 5′ progression of editing through its ability to affect gRNA utilization, both during the transition between specific gRNAs and during usage of certain gRNAs. PMID:20855539

The Effective Teacher's Guide to Autism and Communication Difficulties: Practical Strategies, Second Edition. The Effective Teacher's Guides

ERIC Educational Resources Information Center

Farrell, Michael

2011-01-01

In this welcome second edition of "The Effective Teacher's Guide to Autism and Communication Difficulties", best-selling author Michael Farrell addresses how teachers and others can develop provision for students with autism and students that have difficulties with speech, grammar, meaning, use of language and comprehension. Updated and expanded,…

Atmospheric Sciences. Test Edition. AAAS Study Guides on Contemporary Problems, No. 6.

ERIC Educational Resources Information Center

Schaefer, Vincent J.; Mohnen, Volker A.

This is one of several study guides on contemporary problems produced by the American Association for the Advancement of Science with support of the National Science Foundation. This study guide includes the following sections: (1) Solar Radiation and Its Interaction with the Earth's Atmosphere System; (2) The Water Cycle; (3) Fundamentals of Air…

Ethical Issues and the Life Sciences. Test Edition. AAAS Study Guides on Contemporary Problems.

ERIC Educational Resources Information Center

Kieffer, George H.

This is one of several study guides on contemporary problems produced by the American Association for the Advancement of Science with support of the National Science Foundation. This study guide on Ethical Issues and the Life Sciences includes the following sections: (1) Introduction; (2) The Search for an Ethic; (3) Biomedical Issues including…

The Mortgage Money Guide. Creative Financing for Home Buyers. Updated Edition.

ERIC Educational Resources Information Center

Federal Trade Commission, Washington, DC.

This guide to creative home financing outlines basic concepts needed in shopping for a home loan. Many plans are described so that buyers can make their own decisions. The guide contains three sections: (1) getting started--highlighting the essentials; (2) defining terms; and (3) payment tables. The first section summarizes 15 financing plans in a…

SCDC Spanish Curricula Units. Social Science Strand, Unit 2, Grade One, Teacher's Guide--Multi-Ethnic Edition.

ERIC Educational Resources Information Center

Spanish Curricula Development Center, Miami Beach, FL.

Building on a unit designed to help first graders adjust to the classroom environment, this teacher's guide for the second bilingual social science instructional unit includes material which expands the conceptual field of the child to the family. The Spanish-English guide presents instructional and assessment activities for kits five through…

Who's Involved with Hunger: An Organization Guide for Education and Advocacy. Sixth Edition.

ERIC Educational Resources Information Center

Kutzner, Patricia L.; And Others

This directory provides key information on agencies and organizations instrumental in the fight against hunger. The guide is divided into three parts. Part 1, "Governmental Organizations and Agencies," lists: (1) "U.S. Congress"; (2) "U.S. Federal Government Agencies"; and (3) "United Nations Intergovernmental Organizations." Part 2, "World…

Colorimetric analysis of three editions of the Velhagen-Broschmann pseudoisochromatic colour plates.

PubMed

Kuchenbecker, Jörn; Nicklas, Sven; Behrens-Baumann, Wolfgang

2010-01-01

Chromatic variations across different copies and different editions of pseudoisochromatic tests and violation of underlying principles of construction for individual plates can influence test results. We analysed the colorimetric characteristics of three different editions of Velhagen-Broschmann pseudoisochromatic plates (30th edition printed in 1995, 31st edition printed in 1997, 32nd edition printed in 2000). One hundred and twelve coloured dots of 18 plates were chosen from each edition. We measured RGB and CIE XYZ values using a spectrophotometer. Differences in lightness and chromaticity between corresponding dots of different editions were analysed in terms of Delta L* and Delta u'v', respectively. For each plate deviations from dichromatic confusion lines were analysed. Furthermore, we determined the relative luminance of a target compared to its background in terms of the Weber contrast. The mean Delta L* across editions was 2.05 (+/-1.4) and the mean Delta u'v' was 0.0078 (+/-0.0029). For two plates the deviations of targets from dichromatic confusion lines exceeded suggested values. For a number of plates, the lightness contrast between the symbol and its background was high. Comparison with psychophysical data showed that these colour plates are easily detectable by colour-deficient observers. Lightness and chromatic variation across the three editions was moderate except for a small number of plates perhaps due to inaccuracies in the printing process. The design of several plates should be revised according to standard principles of construction of colour deficiency tests. (c) 2009 S. Karger AG, Basel.

Power Product Equipment Technician: Outboard-Engine Systems and Service. Teacher Edition [and] Student Edition.

ERIC Educational Resources Information Center

Hilley, Robert

This curriculum guide contains teacher and student materials for a course on outboard-engine boat systems and service for power product equipment technician occupations. The course contains the following four units of instruction: (1) Outboard-Engine Design and Identification; (2) Operation and Service of Engine-Support Systems; (3) Operation and…

Power Product Equipment Technician: Outboard-Engine Boat Systems. Teacher Edition [and] Student Edition.

ERIC Educational Resources Information Center

Hilley, Robert

This curriculum guide contains teacher and student materials for a course on outboard-engine boat systems for power product equipment technician occupations. The course contains the following three units of instruction: (1) Orientation to Outboard-Engine Boat Systems and Rigging; (2) Trailers and Safe Towing and Boat Operation; and (3) Seasonal…

Beginning the Principalship. A Practical Guide for New School Leaders. Third Edition

ERIC Educational Resources Information Center

Daresh, John C.

2006-01-01

This new edition of John C. Daresh's bestseller provides the resources needed to become a strong and effective leader. The reader will find out have they can: (1) Manage others' expectations as principal; (2) Master the technical skills necessary to run a school; (3) Create and clarify a personal professional growth plan; (4) Work effectively…

Official Study Guide for the Certified Park and Recreation Professional. Fourth Edition

ERIC Educational Resources Information Center

Mulvaney, Michael A.; Hurd, Amy R.

2013-01-01

The "Official Study Guide for the CPRP Examination" provides up-to-date information in this new edition to assist the park and recreation professional in preparing for the CPRP examination. The study guide serves as an excellent source of information for any individual who works directly or indirectly in the field of park and recreation services.

An efficient system for selectively altering genetic information within mRNAs

PubMed Central

Montiel-González, Maria Fernanda; Vallecillo-Viejo, Isabel C.; Rosenthal, Joshua J. C.

2016-01-01

Site-directed RNA editing (SDRE) is a strategy to precisely alter genetic information within mRNAs. By linking the catalytic domain of the RNA editing enzyme ADAR to an antisense guide RNA, specific adenosines can be converted to inosines, biological mimics for guanosine. Previously, we showed that a genetically encoded iteration of SDRE could target adenosines expressed in human cells, but not efficiently. Here we developed a reporter assay to quantify editing, and used it to improve our strategy. By enhancing the linkage between ADAR's catalytic domain and the guide RNA, and by introducing a mutation in the catalytic domain, the efficiency of converting a UAG premature termination codon (PTC) to tryptophan (UGG) was improved from ∼11 % to ∼70 %. Other PTCs were edited, but less efficiently. Numerous off-target edits were identified in the targeted mRNA, but not in randomly selected endogenous messages. Off-target edits could be eliminated by reducing the amount of guide RNA with a reduction in on-target editing. The catalytic rate of SDRE was compared with those for human ADARs on various substrates and found to be within an order of magnitude of most. These data underscore the promise of site-directed RNA editing as a therapeutic or experimental tool. PMID:27557710

47 CFR 24.202 - Service areas.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS... 1992 Commercial Atlas & Marketing Guide, 123rd Edition, at pages 38-39 (“BTA/MTA Map”). Rand McNally... Commercial Atlas & Marketing Guide, 123rd Edition, at pages 38-39, with the following exceptions and...

47 CFR 24.202 - Service areas.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS... 1992 Commercial Atlas & Marketing Guide, 123rd Edition, at pages 38-39 (“BTA/MTA Map”). Rand McNally... Commercial Atlas & Marketing Guide, 123rd Edition, at pages 38-39, with the following exceptions and...

AIDS: What Young Adults Should Know. Student Guide. Second Edition.

ERIC Educational Resources Information Center

Yarber, William L.

This guide provides information on what Acquired Immune Deficiency Syndrome (AIDS) is, how it is transmitted, and how it can be prevented. The introductory material contains two self-tests on AIDS and HIV infection. The main part of the guide has five sections: (1) AIDS: What It Is; (2) HIV/AIDS: The Size of the Problem; (3) HIV: How It Is…

Self-Study and Evaluation Guide/1977 Edition. Section D-2A: Orientation and Mobility Services.

ERIC Educational Resources Information Center

National Accreditation Council for Agencies Serving the Blind and Visually Handicapped, New York, NY.

This self-study and evaluation guide on orientation and mobility services is one of 28 guides designed for organizations undertaking a self-study as part of the process for accreditation from the National Accreditation Council (NAC) for agencies serving the blind and visually handicapped. Provided are lists of standards to be appraised by the…

Ten Ways To Fight Hate. A Community Response Guide. [Second Edition].

ERIC Educational Resources Information Center

Carrier, Jim

This guide enumerates 10 principles for fighting hate: (1) act; (2) unite; (3) support the victims; (4) do your homework; (5) create an alternative; (6) speak up; (7) lobby leaders; (8) look long range; (9) teach tolerance; and (10) dig deeper. The guide also presents a collection of inspiring stories of people who acted, often alone at first, to…

Origin of Man: Problems in the Interpretation of New Evidence. Test Edition. AAAS Study Guides on Contemporary Problems.

ERIC Educational Resources Information Center

Almquist, Alan J.; Cronin, John E.

This is one of several study guides on contemporary problems produced by the American Association for the Advancement of Science with support of the National Science Foundation. This guide focuses on the origin of man. Part I, The Biochemical Evidence for Human Evolution, contains four sections: (1) Introduction; (2) Macromolecular Data; (3)…

Healthy Teens: Facing the Challenges of Young Lives. A Practical Guide for Parents, Caregivers, Educators, and Health Professionals. Third Edition.

ERIC Educational Resources Information Center

McCarthy, Alice R.

This monograph is a guide to teen development and the world of 11-18 year olds in contemporary America. It provides practical suggestions to parents and other concerned adults as they guide children through adolescence. The 12 chapters are: (1) "Healthy Bodies, Healthy Minds"; (2) "Teens, Families, and Schools"; (3) "Teens…

The Relationship between Conservation Policy and Aquatic Genetic Resources. In: T.R. Tiersch and C.C. Green (eds.) Cryopreservation in Aquatic Species, 2nd Edition. World Aquaculture Society, Baton Rouge, LA.

USDA-ARS?s Scientific Manuscript database

Globally there is an increased awareness of how important genetic resources are for all forms of agriculture. This awareness has resulted in questions concerning the policies countries and the international community should pursue to ensure the sustainable use of diverse genetic resources. For aquac...

Prison Education in England and Wales. (2nd Revised Edition). Mendip Papers MP 022.

ERIC Educational Resources Information Center

Ripley, Paul

In response to prison disturbances in England and Wales in the late 1980s, the education program for prisoners was improved and more prisoners were given access to educational services. Although education is a relatively new phenomenon in the English and Welsh penal system, by the 20th century, education had become an integral part of prison life.…

Overview of Germany: The Federal Republic and the Federal States. Social Studies Grades 6-8. Update 1995. 2nd Revised Edition.

ERIC Educational Resources Information Center

Blankenship, Glen; Tinkler, D. William

This packet is designed for middle school classrooms. The four lessons correspond to the typical curriculum pattern of world cultures, geography and government. The materials focus on world studies and state studies from a comparative U.S./Germany perspective. The lessons include: (1) "Culture and Perspective Taking on the Federal Republic of…

Guidelines for Evaluating...The First-Year Experience at Four-Year Colleges. 2nd Edition.

ERIC Educational Resources Information Center

Gardner, John N.; Barefoot, Betsy O.; Swing, Randy L.

This booklet contains a blueprint of questions that can be used at public and private four-year colleges and universities by an institution-wide task force examining the first-year experience or the broader campus experience. The blueprint can also be used to aid in an overall process of campus self-study or assessment. The questions a task force…

Agile Methods in Air Force Sustainment: Status and Outlook

DTIC Science & Technology

2014-10-01

manage for it through iterations, anticipation and adaptation  unleash creativity and innovation by recognizing that individuals are the ultimate...073561993X X X Agile Project Management : Creating Innovative Products – 2nd Edition Jim Highsmith ISBN 0321658396 X Agile Retrospectives...X Leading Change John Kotter ISBN 0875847471 X Leading Geeks: How to Manage and Lead the People Who Deliver Technology Paul Glen ISBN

Field-effect transistors (2nd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Bocharov, L. N.

The design, principle of operation, and principal technical characteristics of field-effect transistors produced in the USSR are described. Problems related to the use of field-effect transistors in various radioelectronic devices are examined, and tables of parameters and mean statistical characteristics are presented for the main types of field-effect transistors. Methods for calculating various circuit components are discussed and illustrated by numerical examples.

Integrating Global Trends Information Into Army Strategic Planning Processes

DTIC Science & Technology

1993-06-01

There will inevitably be a need to clarify survey responses with the participants. Followup would also provide an opportunity to establish personal ...with the participants. Followup would also provide an opportunity to e~tablih personal contact with the experts, which would promote participation...Plublications Inc., Dallas, 1990). UNCITE!) Aaker , D.A. .Strategic Market Managemient, 2nd Edition. (New York: John Wiley. 1988). "Army Environmental

Response to Intervention and Continuous School Improvement: How to Design, Implement, Monitor, and Evaluate a School-Wide Prevention System, 2nd Edition

ERIC Educational Resources Information Center

Bernhardt, Victoria L.; Hébert, Connie L.

2017-01-01

Experts Bernhardt and Hébert's latest book demonstrates strategies to ensure your entire staff works together to design, implement, monitor, and evaluate a schoolwide prevention system with integrity and fidelity. Each step in this important resource is designed to help administrators, teachers, and other educators improve the learning of every…

Validity of the KABC-II Culture-Language Interpretive Matrix: A Comparison of Native English Speakers and Spanish-Speaking English Language Learners

ERIC Educational Resources Information Center

Van Deth, Leah M.

2013-01-01

The purpose of the present study was to investigate the validity of the Culture-Language Interpretive Matrix (C-LIM; Flanagan, Ortiz, & Alfonso, 2013) when applied to scores from the Kaufman Assessment Battery for Children, 2nd Edition (KABC-II; Kaufman & Kaufman, 2004). Data were analyzed from the KABC-II standardization sample as well as…

Action for a Cleaner Tomorrow: A South Carolina Environmental Curriculum Grades 6-12, 2nd Edition.

ERIC Educational Resources Information Center

South Carolina State Dept. of Health and Environmental Control, Columbia.

The goal of this curriculum is to teach students to think about their daily habits and to make environmentally responsible choices. The lessons and activities are divided by grade levels: 6-8 and 9-12. Lessons in each grade level are designed to cover a range of student skills, subject areas, and environmental issues. An extensive resource section…

Interpersonal Communication & Problem Solving. Workplace Education. Instructor's Guide (Revised Edition for Publication). Project ALERT.

ERIC Educational Resources Information Center

Blount, Joan, Comp.; Ruetz, Nancy, Ed.

This instructor's guide contains materials for a 40-hour course that explores interpersonal communication and improves participants' ability to communicate with fellow workers and family members. A title page provides a course description with target audience and general objective. An introduction covers design of the 10-week course, with 2 2-hour…

The association between symptoms of autism and neuropsychological performance in females with Anorexia Nervosa.

PubMed

Westwood, Heather; Mandy, William; Tchanturia, Kate

2017-12-01

The aim of this study was to investigate the relationship between symptoms of autism spectrum disorder (ASD) and performance on measures of set-shifting and central coherence in a sample of females with anorexia nervosa (AN). Ninety-nine females aged 12-47, recruited from inpatient and day patient eating disorder services, were assessed with the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2), as well as the Wechsler Abbreviated Scale of Intelligence, 2nd edition (WASI-II); Wisconsin Card Sorting Test (WCST); Rey-Osterrieth Complex Figure Test (ROCFT) and self-report questionnaires assessing eating disorder pathology, depression, cognitive rigidity and attention to detail. Individuals scoring above clinical cut-off on the ADOS-2 (N = 35) reported significantly higher levels of cognitive rigidity than those with lower levels of ASD symptoms but there was no difference between groups on self-reported attention to detail. There group with high levels of ASD symptoms also made significantly more perseverative errors on the WCST but there was no association between ASD symptoms and performance on the ROCFT. The group who scored above cut-off on the ADOS-2 were significantly younger than the sub-clinical groups. The presence of symptoms associated with ASD appears to be related to increased cognitive rigidity in females with AN. Copyright © 2017. Published by Elsevier B.V.

Creating a Culture of Human Rights, Democracy and Peace in the New Millennium. Proceedings of the International Conference on Children's Rights Education (2nd, Victoria, British Columbia, August 18-22, 2001).

ERIC Educational Resources Information Center

Blanchet-Cohen, Natasha; Hart, Stuart; Cook, Philip

The 2nd International Conference on Children's Rights in Education hosted approximately 150 child-centered international policy makers, who discussed the implications and implementation of children's rights to guide educational policy, research, and practice. This report presents an annotated agenda of the conference proceedings and, based on the…

The Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5): Background and rationale.

PubMed

Davis, Gavin A; Purcell, Laura; Schneider, Kathryn J; Yeates, Keith Owen; Gioia, Gerard A; Anderson, Vicki; Ellenbogen, Richard G; Echemendia, Ruben J; Makdissi, Michael; Sills, Allen; Iverson, Grant L; Dvořák, Jiří; McCrory, Paul; Meeuwisse, Willem; Patricios, Jon; Giza, Christopher C; Kutcher, Jeffrey S

2017-06-01

This article presents the Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5). The Sport Concussion Assessment Tool was introduced in 2004, following the 2nd International Conference on Concussion in Sport in Prague, Czech Republic. Following the 4th International Consensus Conference, held in Zurich, Switzerland, in 2012, the SCAT 3rd edition (Child SCAT3) was developed for children aged between 5 and12 years. Research to date was reviewed and synthesised for the 5th International Consensus Conference on Concussion in Sport in Berlin, Germany, leading to the current revision of the test, the Child SCAT5. This article describes the development of the Child SCAT5. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Stirling engine design manual, 2nd edition

NASA Technical Reports Server (NTRS)

Martini, W. R.

1983-01-01

This manual is intended to serve as an introduction to Stirling cycle heat engines, as a key to the available literature on Stirling engines and to identify nonproprietary Stirling engine design methodologies. Two different fully described Stirling engines are discussed. Engine design methods are categorized as first order, second order, and third order with increased order number indicating increased complexity. FORTRAN programs are listed for both an isothermal second order design program and an adiabatic second order design program. Third order methods are explained and enumerated. In this second edition of the manual the references are updated. A revised personal and corporate author index is given and an expanded directory lists over 80 individuals and companies active in Stirling engines.

A compendium of fossil marine animal families, 2nd edition

NASA Technical Reports Server (NTRS)

Sepkoski, J. J. Jr; Sepkoski JJ, J. r. (Principal Investigator)

1992-01-01

A comprehensive listing of 4075 taxonomic families of marine animals known from the fossil record is presented. This listing covers invertebrates, vertebrates, and animal-like protists, gives time intervals of apparent origination and extinction, and provides literature sources for these data. The time intervals are mostly 81 internationally recognized stratigraphic stages; more than half of the data are resolved to one of 145 substage divisions, providing more highly resolved data for studies of taxic macroevolution. Families are classified by order, class, and phylum, reflecting current classifications in the published literature. This compendium is a new edition of the 1982 publication, correcting errors and presenting greater stratigraphic resolution and more current ideas about acceptable families and their classification.

Learning by Doing: A Handbook for Professional Learning Communities at Work™ (Second Edition)-- Action Guide

ERIC Educational Resources Information Center

Solution Tree, 2010

2010-01-01

This action guide is intended to assist in the reading of and reflection upon "Learning by Doing: A Handbook for Professional Learning Communities at Work, Second Edition" by Richard DuFour, Rebecca DuFour, Richard Eaker, and Thomas Many. The guide can be used by an individual, a small group, or an entire faculty to identify key points,…

Genome editing for human gene therapy.

PubMed

Meissner, Torsten B; Mandal, Pankaj K; Ferreira, Leonardo M R; Rossi, Derrick J; Cowan, Chad A

2014-01-01

The rapid advancement of genome-editing techniques holds much promise for the field of human gene therapy. From bacteria to model organisms and human cells, genome editing tools such as zinc-finger nucleases (ZNFs), TALENs, and CRISPR/Cas9 have been successfully used to manipulate the respective genomes with unprecedented precision. With regard to human gene therapy, it is of great interest to test the feasibility of genome editing in primary human hematopoietic cells that could potentially be used to treat a variety of human genetic disorders such as hemoglobinopathies, primary immunodeficiencies, and cancer. In this chapter, we explore the use of the CRISPR/Cas9 system for the efficient ablation of genes in two clinically relevant primary human cell types, CD4+ T cells and CD34+ hematopoietic stem and progenitor cells. By using two guide RNAs directed at a single locus, we achieve highly efficient and predictable deletions that ablate gene function. The use of a Cas9-2A-GFP fusion protein allows FACS-based enrichment of the transfected cells. The ease of designing, constructing, and testing guide RNAs makes this dual guide strategy an attractive approach for the efficient deletion of clinically relevant genes in primary human hematopoietic stem and effector cells and enables the use of CRISPR/Cas9 for gene therapy.

Major Appliance Repair. Teacher Edition and Student Edition. Second Edition.

ERIC Educational Resources Information Center

Smreker, Gene; Calvert, King

This second edition contains teacher and student guides for 14 units of instruction in major appliance repair. Each unit in the teacher edition includes some or all of the following basic components: objective sheet, suggested activities, answers to assignment sheets, answers to the written test, written test, a unit evaluation form, teacher…

On Improving CRISPR for Editing Plant Genes: Ribozyme-Mediated Guide RNA Production and Fluorescence-Based Technology for Isolating Transgene-Free Mutants Generated by CRISPR.

PubMed

He, Yubing; Wang, Rongchen; Dai, Xinhua; Zhao, Yunde

2017-01-01

CRISPR/Cas9-mediated genome editing technology has been used to successfully edit numerous genes in various organisms including plants. There are still two major challenges in using CRISPR/Cas9 technology for gene editing in plants. First, there are very limited choices of promoters that are suitable for in vivo production of single-guide RNAs (sgRNAs), which is complementary to the target sequence and which guides Cas9 to generate double-strand breaks at the target site. It is especially difficult to produce sgRNA molecules with temporal and spatial precision. Second, there is a lack of efficient methods for identifying plants that (1) contain heritable and stable mutations generated by CRISPR/Cas9, and (2) no longer harbor the CRISPR/Cas9 construct and other transgenes. In this chapter, we describe the development of a ribozyme-based strategy that enables the production of sgRNA molecules from any chosen promoter. More importantly, the ribozyme-based technology makes it feasible to produce sgRNAs with temporal and spatial precision, greatly expanding the scope and applications of CRISPR/Cas9 technology. We also developed a fluorescence-based technology that allows us to efficiently and reliably isolate Cas9-free stable Arabidopsis mutants. Thus, we provide effective protocols to overcome two important obstacles in using CRISPR/Cas9 for editing genes in plants. © 2017 Elsevier Inc. All rights reserved.

Crawling and/or Squatting: A Saleable Work Skill. Occupation Simulation Packet. Grades K-2nd.

ERIC Educational Resources Information Center

Montgomery, Margery

This teacher's guide for grades K-2 contains simulated work experiences for students using the isolated skill concept, crawling and/or squatting. Teacher instructions include objectives, evaluation, and sequence of activities. The guide contains pre-tests and post-tests with instructions and answer keys. Three pre-skill activities are suggested,…

Multiplexed precision genome editing with trackable genomic barcodes in yeast.

PubMed

Roy, Kevin R; Smith, Justin D; Vonesch, Sibylle C; Lin, Gen; Tu, Chelsea Szu; Lederer, Alex R; Chu, Angela; Suresh, Sundari; Nguyen, Michelle; Horecka, Joe; Tripathi, Ashutosh; Burnett, Wallace T; Morgan, Maddison A; Schulz, Julia; Orsley, Kevin M; Wei, Wu; Aiyar, Raeka S; Davis, Ronald W; Bankaitis, Vytas A; Haber, James E; Salit, Marc L; St Onge, Robert P; Steinmetz, Lars M

2018-07-01

Our understanding of how genotype controls phenotype is limited by the scale at which we can precisely alter the genome and assess the phenotypic consequences of each perturbation. Here we describe a CRISPR-Cas9-based method for multiplexed accurate genome editing with short, trackable, integrated cellular barcodes (MAGESTIC) in Saccharomyces cerevisiae. MAGESTIC uses array-synthesized guide-donor oligos for plasmid-based high-throughput editing and features genomic barcode integration to prevent plasmid barcode loss and to enable robust phenotyping. We demonstrate that editing efficiency can be increased more than fivefold by recruiting donor DNA to the site of breaks using the LexA-Fkh1p fusion protein. We performed saturation editing of the essential gene SEC14 and identified amino acids critical for chemical inhibition of lipid signaling. We also constructed thousands of natural genetic variants, characterized guide mismatch tolerance at the genome scale, and ascertained that cryptic Pol III termination elements substantially reduce guide efficacy. MAGESTIC will be broadly useful to uncover the genetic basis of phenotypes in yeast.

America's Hero to the World, George C. Marshall. Teacher's Guide. Second Edition [and] Resource Packet [and] George C. Marshall: An American Leader. A Teacher's Notebook.

ERIC Educational Resources Information Center

Thompson, Rachel Yarnell; Sittig, Linda H.

This teaching unit about George C. Marshall contains a teacher's guide, a resource packet, and a teacher's notebook. The teacher's guide includes ten introductory, overarching, and culminating activities: (1) About this Guide; (2) Getting to Know Him; (3) Marshal on Video; (4) Share a Space with a Hero; (5) On a Global Stage--Links; (6) A Picture…

Challenging Science and Literacy Activities for K-9 Students--The Cricket Chronicles. Teacher Edition

ERIC Educational Resources Information Center

Matthews, Catherine E.

2006-01-01

This book is an extensive integrated unit of study focused on that common and familiar insect--the cricket. In this edition, teachers are given a complete guide and reproducible worksheets for elementary and middle school students. With over 30 different activities on crickets, students learn science content and skills including: (1) Taxonomy; (2)…

Reduce, Reuse, Recycle: An ESL Textbook/Workbook [In Four Volumes]: (1) Teaching Guide; (2) Edition A. Key Vocabulary Words Translated into 6 Languages: Hmong, Laotian, Korean, Cambodian, Vietnamese, Chinese; (3) Edition B. Key Vocabulary Words Translated into 6 Languages: Spanish, Somali, Russian, Farsi, Bosnian, Arabic; (4) Edition C. Key Vocabulary Words Translated in 6 Languages: Spanish, Russian, Bosnian, Somali, Vietnamese, Hmong.

ERIC Educational Resources Information Center

LaRue, Charles

Each of these three separately-published textbook/workbook editions on the topic of recycling presents key vocabulary words relating to this topic for English as a Second Language students in six languages. These books are designed to increase students' understanding of what the most typical local recycling rules are, why complying with them is…

Y.E.S. International Entomology Resource Guide. Second Edition. Special Publication No. 2.

ERIC Educational Resources Information Center

Dunn, Gary A., Comp.

This resource guide is designed to provide Young Entomologists' Society (Y.E.S.) members and other interested entomologists with information on people and companies that sell entomological equipment, supplies, services, preserved and dried specimens, livestock, books, publications, slides and other visuals, gift or novelty items, and…

Delivering Instruction to Adult Learners. Revised Edition.

ERIC Educational Resources Information Center

Cantor, Jeffrey A.

This one-stop guide for trainers and educators of adults in industry, business, or the professions details a results-oriented instructional strategy that is based on the following principles for instructing adults effectively: (1) act as a leader, helper, guide, change agent, coordinator, and facilitator of learning; (2) promote active…

Therapeutic Genome Editing and its Potential Enhancement through CRISPR Guide RNA and Cas9 Modifications.

PubMed

Batzir, Nurit Assia; Tovin, Adi; Hendel, Ayal

2017-06-01

Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. The genome editing process relies on creating a site-specific DNA double-strand break (DSB) by engineered nucleases and then allowing the cell's repair machinery to repair the break such that precise changes are made to the DNA sequence. The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing accelerates the progress towards using genome editing as a new approach to human therapeutics. Here we review how genome editing using engineered nucleases works and how using different genome editing outcomes can be used as a tool set for treating human diseases. We then review the major challenges of therapeutic genome editing and we discuss how its potential enhancement through CRISPR guide RNA and Cas9 protein modifications could resolve some of these challenges. Copyright© of YS Medical Media ltd.

The Art of Electronics - 2nd Edition

NASA Astrophysics Data System (ADS)

Horowitz, Paul; Hill, Winfield

1989-09-01

This is the thoroughly revised and updated second edition of the hugely successful The Art of Electronics. Widely accepted as the single authoritative text and reference on electronic circuit design, both analog and digital, the original edition sold over 125,000 copies worldwide and was translated into eight languages. The book revolutionized the teaching of electronics by emphasizing the methods actually used by citcuit designers - a combination of some basic laws, rules to thumb, and a large nonmathematical treatment that encourages circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits. The best self-teaching book and reference book in electronics Simply indispensable, packed with essential information for all scientists and engineers who build electronic circuits Totally rewritten chapters on microcomputers and microprocessors The first edition of this book has sold over 100,000 copies in seven years, it has a market in virtually all research centres where electronics is important

Introduction to Energy - 2nd Edition

NASA Astrophysics Data System (ADS)

Cassedy, Edward S.; Grossman, Peter Z.

1998-12-01

Energy issues such as pollution, resource depletion, global warming, nuclear power and waste are problems that demand timely solutions. This book provides a critical examination of the resources, market forces, and social impacts of modern energy production. The book addresses the dilemmas that have arisen due to society's crucial dependence on energy, particularly fossil fuels, and explores the available alternative energy producing technologies. The second edition has increased emphasis on those issues at the forefront of the current energy debate: energy sustainability, climate change, and the radical restructuring of the power industry due to de-regulation. Assuming no prior technical expertise and avoiding complex mathematical formulation, it is directed at a broad readership. The second edition will follow the first in proving especially useful as a textbook for undergraduate programs in Science, Technology and Society (STS), and as a supplementary text in a variety of courses which touch upon energy studies, including environmental and technology policy, environmental, mineral and business law, energy and resource economics. Fully updated second edition of successful first edition that was adopted on Science, Technology and Society courses Provides a critical examination of all aspects of modern energy production for non-technical readers For a broad readership from a variety of backgrounds

Select Agent and Toxin Regulations: Beyond the Eighth Edition of the Guide for the Care and Use of Laboratory Animals

PubMed Central

Kastenmayer, Robin J; Moore, Rashida M; Bright, Allison L; Torres-Cruz, Rafael; Elkins, William R

2012-01-01

In the interval between the publication of the seventh and eighth editions of the Guide for the Care and Use of Laboratory Animals (Guide), much has changed with regard to the regulation and funding of highly pathogenic biologic agents and toxins (Select Agents). Funding of research involving highly pathogenic agents has increased dramatically during this time, thus increasing the demand for facilities capable of supporting this work. The eighth edition of the Guide briefly mentions Select Agents and provides a limited set of references. Here we provide some background information regarding the relevant laws and regulations, as well as an overview of the programmatic requirements pertaining to the use of Select Agents, with a focus on use in animals. PMID:22776191

Information Resource Sharing and Networking. 2nd Revised and Amended Edition. Report on Three Training Courses (Arusha, Tanzania, October 22-November 2, 1990; Mombasa, Kenya, April 15-26, 1991; Arusha, Tanzania, March 23-April 3, 1992).

ERIC Educational Resources Information Center

Musana, Augustes, Ed.; Huttemann, Lutz, Ed.

From 1989 to 1991, the German Foundation for International Development has organized a series of seminars and training courses for Eastern African countries given in concert with national and regional partner organizations to assist in providing improved information and documentation services. Selected papers and lecture notes from three training…

An Annotated Bibliography of MANPRINT-Related Assessments and Evaluations Conducted by the U.S. Army, 2nd Edition: 1953 to 2009. Volume 2 - MANPRINT Assessment and Evaluations

DTIC Science & Technology

2010-02-01

Research Laboratory Aberdeen Proving Ground, MD 21005-5425 ARL-SR-189 February 2010 An Annotated Bibliography of MANPRINT-Related...Middlebrooks, Ph.D. Human Research and Engineering Directorate, ARL Approved for public release; distribution...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: RDRL-HRM-AV Fort Hood, TX 76544-5073 8. PERFORMING

Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

ERIC Educational Resources Information Center

Knapp, John; Harper, Eddie

This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

33 CFR 156.111 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

33 CFR 156.111 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

33 CFR 156.111 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

33 CFR 156.111 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

33 CFR 156.111 - Incorporation by reference.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., England. Ship to Ship Transfer Guide (Petroleum), Second Edition, 1988—156.330. International Chamber of Shipping 12 Carthusian Street, London EC1M 6EB, England. Guide to Helicopter/Ship Operations, Third Edition...

Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

ERIC Educational Resources Information Center

Hilley, Robert

The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction…

A Counselor's Guide to Career Assessment Instruments, Sixth Edition

ERIC Educational Resources Information Center

Wood, Chris; Hays, Danica G.

2013-01-01

This book contains exemplary resources for counselors, career development facilitators, school counselors, and other career professionals working in a variety of settings. This edition is an essential guide to career assessment and contains a comprehensive list of career assessment instruments. It has over 70 reviews and includes…

Science, Society, and America's Nuclear Waste: Ionizing Radiation, Unit 2. Teacher Guide. Second Edition.

ERIC Educational Resources Information Center

Department of Energy, Washington, DC. Office of Civilian Radioactive Waste Management, Washington, DC.

This guide is Unit 2 of the four-part series, Science, Society, and America's Nuclear Waste, produced by the U.S. Department of Energy's Office of Civilian Radioactive Waste Management. The goal of this unit is to convey factual information relevant to radioactivity and radiation and relate that information both to the personal lives of students…

Sperm quality assessment in mammals by flow cytometry In: T.R. Tiersch and C.C. Green (eds.) Cryopreservation in Aquatic Species, 2nd Edition. World Aquaculture Society, Baton Rouge, LA.

USDA-ARS?s Scientific Manuscript database

The fertility of a semen sample can not be predicted whereas the potential for poor fertility can be estimated by evaluating as many physiologic and morphologic factors as possible (Amann and Hammerstedt, 2002). This rationale is based on the ideology that while a significant amount of information ...

The USDA national animal germplasm program and the aquatic species collection. In: T.R. Tiersch and C.C. Green (eds.) Cryopreservation in Aquatic Species, 2nd Edition. World Aquaculture Society, Baton Rouge, LA

USDA-ARS?s Scientific Manuscript database

Diverse genetic resources and the genetic variability within species are the raw materials by which the productivity of aquatic species populations can be increased for food production. Due to the importance of these resources there is growing international awareness that these resources are importa...

Proceedings from the Nordic Conference for English Studies (2nd, Hanasaari/Hanaholmen, Finland, May 19-21, 1983). Meddelanden fran Stiftelsens for Abo Academi Forskningsinstitut Nr. 92.

ERIC Educational Resources Information Center

Ringbom, Hakan, Ed.; Rissanen, Matti, Ed.

The 50 papers on English language and literature included in this compilation are grouped under the following headings: Old English (editing "Judgment Day," the syntactic types "every man" and "each of men," and continuity and variation in psalm glosses); Present-Day English (speech rate and vowel quantity as compared with Finnish): neutralization…

Agile Methods in Air Force Sustainment: Status and Outlook

DTIC Science & Technology

2014-07-01

Schwaber ISBN10: 073561993X X X Agile Project Management : Creating Innovative Products – 2nd Edition Jim Highsmith ISBN 0321658396 X Agile...ISBN 0787974277 X Leading Change John Kotter ISBN 0875847471 X Leading Geeks: How to Manage and Lead the People Who Deliver Technology Paul ...Development: Achieving Enterprise Agility Alan Shalloway, Guy Beaver, and James R. Trott ISBN 0321532899 X Managing Transitions: Making the Most of

A Common Interface Real-Time Multiprocessor Operating System for Embedded Systems

DTIC Science & Technology

1991-03-04

Pressman , a design methodology should show hierarchical organization, lead to modules exhibiting independent functional characteristics, and be derived...Boehm, Barry W. "Software Engineering," Tutorial: Software Design Strategies, 2nd Edition. 35-50. Los Angeles CA: IEEE Computer Society Press, 1981... Pressman , Roger S. Software Engineering: A Practitioner’s Approach, Second Edi- tion. McGraw-Hill Book Company, New York, 1988. 59. Quinn, Michael J

Handbook of Career Counseling for Women. 2nd Edition. Contemporary Topics in Vocational Psychology Series

ERIC Educational Resources Information Center

Walsh, W. Bruce, Ed.; Heppner, Mary, Ed.

2006-01-01

The goal of this book is to give career counselors knowledge awareness, and skills to work with diverse girls and women to make their lives as authentic, meaningful, and rewarding as they can possibly be. It is designed to help career counselors work with diverse girls and women as they pursue the ever widening choices in their lives. In addition,…

A Kid Like Me Across the Sea: A Look into the World of a German Child. Update, 1995. Social Studies Grades 3-4. 2nd Revised Edition.

ERIC Educational Resources Information Center

Blankenship, Glen; Muller, Martina, Ed.

This packet is a primary/elementary instructional package targeted at grades 3-4. The four lessons address physical and cultural geography, basic needs, community services and community helpers, transportation and communication, and political symbols. The materials focus on a comparative U.S./German perspective. The lessons include: (1)…

Pediatric Psychosocial Oncology: A Quick Reference on the Psychosocial Dimensions of Cancer Symptom Management | Center for Cancer Research

Cancer.gov

The 2nd Edition of the handbook, Pediatric Psycho-Oncology: A Quick Reference on the Psychosocial Dimensions of Cancer Symptom Management, by Oxford Press, 2015 fills an important niche, as it provides practical hands-on information on many aspects of psychological and psychiatric aspects of pediatric oncology care.  It is organized with sections addressing specific clinical

Dissemination Of Evidence-Based CBT Intervention Components: Online Self-Administered Training For Providers Treating Military Deployment-Related PTSD

DTIC Science & Technology

2010-08-01

eye movement desensitization and reprocessing ( EMDR ), fluoxetine, and pill placebo in the treatment of posttraumatic...stress disorder: treatment effects and long-term maintenance. J Clin Psychiatry;68(1):37-46. 2007. 5. Shapiro F. Eye movement desensitization and ... reprocessing : Basic principles, protocols, and procedures (2nd edition). New York: Guilford Press. 2001. 6. Monson CM, Schnurr PP, Resick

RNA editing with CRISPR-Cas13.

PubMed

Cox, David B T; Gootenberg, Jonathan S; Abudayyeh, Omar O; Franklin, Brian; Kellner, Max J; Joung, Julia; Zhang, Feng

2017-11-24

Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level, where disease-relevant sequences can be rescued to yield functional protein products. Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided ribonuclease Cas13. We profiled type VI systems in order to engineer a Cas13 ortholog capable of robust knockdown and demonstrated RNA editing by using catalytically inactive Cas13 (dCas13) to direct adenosine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts in mammalian cells. This system, referred to as RNA Editing for Programmable A to I Replacement (REPAIR), which has no strict sequence constraints, can be used to edit full-length transcripts containing pathogenic mutations. We further engineered this system to create a high-specificity variant and minimized the system to facilitate viral delivery. REPAIR presents a promising RNA-editing platform with broad applicability for research, therapeutics, and biotechnology. Copyright © 2017, American Association for the Advancement of Science.

RNA Editing with CRISPR-Cas13

PubMed Central

Cox, David B.T.; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Franklin, Brian; Kellner, Max J.; Joung, Julia; Zhang, Feng

2017-01-01

Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level, where disease-relevant sequences can be rescued to yield functional protein products. Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided RNases Cas13. Here, we profile Type VI systems to engineer a Cas13 ortholog capable of robust knockdown and demonstrate RNA editing by using catalytically-inactive Cas13 (dCas13) to direct adenosine to inosine deaminase activity by ADAR2 to transcripts in mammalian cells. This system, referred to as RNA Editing for Programmable A to I Replacement (REPAIR), has no strict sequence constraints, can be used to edit full-length transcripts containing pathogenic mutations. We further engineer this system to create a high specificity variant, REPAIRv2, that is 919 times more specific than REPAIRv1 as well as minimize the system to ease viral delivery. REPAIR presents a promising RNA editing platform with broad applicability for research, therapeutics, and biotechnology. PMID:29070703

Encoding Deficits Impede Word Learning and Memory in Adults With Developmental Language Disorders

PubMed Central

Gordon, Katherine; Eden, Nichole; Arbisi-Kelm, Tim; Oleson, Jacob

2017-01-01

Purpose The aim of this study was to determine whether the word-learning challenges associated with developmental language disorder (DLD) result from encoding or retention deficits. Method In Study 1, 59 postsecondary students with DLD and 60 with normal development (ND) took the California Verbal Learning Test–Second Edition, Adult Version (Delis, Kramer, Kaplan, & Ober, 2000). In Study 2, 23 postsecondary students with DLD and 24 with ND attempted to learn 9 novel words in each of 3 training conditions: uncued test, cued test, and no test (passive study). Retention was measured 1 day and 1 week later. Results By the end of training, students with DLD had encoded fewer familiar words (Study 1) and fewer novel words (Study 2) than their ND peers as evinced by word recall. They also demonstrated poorer encoding as evinced by slower growth in recall from Trials 1 to 2 (Studies 1 and 2), less semantic clustering of recalled words, and poorer recognition (Study 1). The DLD and ND groups were similar in the relative amount of information they could recall after retention periods of 5 and 20 min (Study 1). After a 1-day retention period, the DLD group recalled less information that had been encoded via passive study, but they performed as well as their ND peers when recalling information that had been encoded via tests (Study 2). Compared to passive study, encoding via tests also resulted in more robust lexical engagement after a 1-week retention for DLD and ND groups. Conclusions Encoding, not retention, is the problematic stage of word learning for adults with DLD. Self-testing with feedback lessens the deficit. Supplemental Materials https://doi.org/10.23641/asha.5435200 PMID:28980007

The Monthly Sky Guide: Sixth Edition

NASA Astrophysics Data System (ADS)

Ridpath, Ian; Tirion, Wil

2003-06-01

The latest edition of Ian Ridpath and Wil Tirion's popular guide to the night sky is updated for planet positions and forthcoming eclipses up to the end of the year 2007. With one chapter for each month of the year, this is an easy-to-use handbook for anyone wanting to identify constellations, star clusters, nebulae, to plot the movement of planets, or witness solar and lunar eclipses. Most of the features discussed are visible to the naked eye and all can be seen with a small telescope or binoculars. Ian Ridpath has been a full-time writer, broadcaster and lecturer on astronomy and space for more than twenty-five years. He has written and edited more than 40 books, including A Comet Called Haley (Cambridge, 1985). Wil Tirion made his first star map in 1977. It showed stars to the magnitude of 6.5 and was issued as a set of maps by the British Astronomical Association in 1981. He has illustrated numerous books and magazines, including The Cambridge Star Atlas (Cambridge, 2001). Previous Edition Pb (1999): 0-521-66771-2

Career Planner. A Guide for Students with Disabilities. Second Edition.

ERIC Educational Resources Information Center

Smith, Gwen J.; And Others

This handbook is intended as a guide for disabled career planners who wish to enter the work force. The introduction presents basic steps for gathering information about oneself and about jobs. Chapter 1 discusses collecting health/medical information. A sample form is provided. Chapter 2 focuses on collecting vocational information, which…

Concrete in the Field-II; Instructor's Guide; Pilot Program Edition.

ERIC Educational Resources Information Center

Portland Cement Association, Cleveland, OH.

This guide, prepared for a 2-year course in junior colleges and technical institutes, is designed to be a national program to train persons for employment as technicians in the cement and concrete industries. Included are 48 session outlines divided into six units of study. Each unit contains objectives, outline, related information, and…

Global Climate Change Pathfinder: A Guide to Information Resources. Second Edition.

ERIC Educational Resources Information Center

Pintozzi, Chestalene; Jones, Douglas E.

This pathfinder is a guide to scientific and technical aspects of global climate change including meteorological and climatological aspects; biological, agricultural, and public policy implications; and the chemical processes involved. Sources are arranged by type of publication and include: (1) 10 reference sources; (2) 12 bibliographies; (3) 44…

Let's Celebrate! A World of Healthy Foods. Second Edition.

ERIC Educational Resources Information Center

Hibbs, Sharon, Ed.

This guide was developed to help students in West Virginia learn healthy eating habits and attitudes, primarily by preparing and eating food. The guide suggests activities, recipes and resources to help students: (1) enjoy a variety of nutritious foods; (2) feel competent about trying unfamiliar foods; (3) understand cultural influences on food…

Including Students with Special Needs: A Practical Guide for Classroom Teachers. Third Edition.

ERIC Educational Resources Information Center

Friend, Marilyn; Bursuck, William D.

This book is intended to guide teachers as they include students with special needs. The 13 chapters are: (1) "The Foundation for Educating Students with Special Needs" (e.g., issues related to inclusion); (2) "Special Education Procedures and Services" (e.g., how students obtain special services); (3) "Professional…

Engineered Cpf1 variants with altered PAM specificities.

PubMed

Gao, Linyi; Cox, David B T; Yan, Winston X; Manteiga, John C; Schneider, Martin W; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Zhang, Feng

2017-08-01

The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif (PAM) in the DNA substrate. To address this limitation, we performed a structure-guided mutagenesis screen to increase the targeting range of Cpf1. We engineered two AsCpf1 variants carrying the mutations S542R/K607R and S542R/K548V/N552R, which recognize TYCV and TATV PAMs, respectively, with enhanced activities in vitro and in human cells. Genome-wide assessment of off-target activity using BLISS indicated that these variants retain high DNA-targeting specificity, which we further improved by introducing an additional non-PAM-interacting mutation. Introducing the identified PAM-interacting mutations at their corresponding positions in LbCpf1 similarly altered its PAM specificity. Together, these variants increase the targeting range of Cpf1 by approximately threefold in human coding sequences to one cleavage site per ∼11 bp.

Engineered Cpf1 variants with altered PAM specificities increase genome targeting range

PubMed Central

Gao, Linyi; Cox, David B.T.; Yan, Winston X.; Manteiga, John C.; Schneider, Martin W.; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Zhang, Feng

2017-01-01

The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells1–7. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif (PAM) in the DNA substrate. To address this limitation, we performed a structure-guided mutagenesis screen to increase the targeting range of Cpf1. We engineered two AsCpf1 variants carrying the mutations S542R/K607R and S542R/K548V/N552R, which recognize TYCV and TATV PAMs, respectively, with enhanced activities in vitro and in human cells. Genome-wide assessment of off-target activity using BLISS7 assay indicated that these variants retain high DNA targeting specificity, which we further improved by introducing an additional non-PAM-interacting mutation. Introducing the identified mutations at their corresponding positions in LbCpf1 similarly altered its PAM specificity. Together, these variants increase the targeting range of Cpf1 by approximately three-fold in human coding sequences to one cleavage site per ~11 bp. PMID:28581492

Development and Validation of Big Four Personality Scales for the Schedule for Nonadaptive and Adaptive Personality-2nd Edition (SNAP-2)

PubMed Central

Calabrese, William R.; Rudick, Monica M.; Simms, Leonard J.; Clark, Lee Anna

2012-01-01

Recently, integrative, hierarchical models of personality and personality disorder (PD)—such as the Big Three, Big Four and Big Five trait models—have gained support as a unifying dimensional framework for describing PD. However, no measures to date can simultaneously represent each of these potentially interesting levels of the personality hierarchy. To unify these measurement models psychometrically, we sought to develop Big Five trait scales within the Schedule for Adaptive and Nonadaptive Personality–2nd Edition (SNAP-2). Through structural and content analyses, we examined relations between the SNAP-2, Big Five Inventory (BFI), and NEO-Five Factor Inventory (NEO-FFI) ratings in a large data set (N = 8,690), including clinical, military, college, and community participants. Results yielded scales consistent with the Big Four model of personality (i.e., Neuroticism, Conscientiousness, Introversion, and Antagonism) and not the Big Five as there were insufficient items related to Openness. Resulting scale scores demonstrated strong internal consistency and temporal stability. Structural and external validity was supported by strong convergent and discriminant validity patterns between Big Four scale scores and other personality trait scores and expectable patterns of self-peer agreement. Descriptive statistics and community-based norms are provided. The SNAP-2 Big Four Scales enable researchers and clinicians to assess personality at multiple levels of the trait hierarchy and facilitate comparisons among competing “Big Trait” models. PMID:22250598

How to Conduct Surveys: A Step-by-Step Guide. Sixth Edition

ERIC Educational Resources Information Center

Fink, Arlene

2016-01-01

Packed with new topics that reflect today's challenges, the Sixth Edition of the bestselling "How to Conduct Surveys" guides readers through the process of developing their own rigorous surveys and evaluating the credibility and transparency of surveys created by others. Offering practical, step-by-step advice and written in the same…

A Resource Guide to Assistive Technology for Memory and Organization. Second Edition.

ERIC Educational Resources Information Center

McHale, Kathy; McHale, Sara, Ed.

The second edition of this guide to assistive technology for memory and organization is intended for professionals working with people who have learning disabilities, attention deficit disorders, neurological conditions, and psychological problems. It contains expanded and new appendices as well as new information about free Internet resources,…

Employment in Agribusiness. Teacher Edition. Second Edition.

ERIC Educational Resources Information Center

Crummett, Dan M.; Newport, Alan K.

This curriculum guide is designed to help teachers prepare students with the variety of skills that will help them obtain jobs that can turn into rewarding careers in agribusiness. The guide also serves as a resource for students participating in agricultural sales and service competitions sponsored by student organizations such as Future Farmers…

Food Service Management. Second Edition. Answer Book/Teacher's Guide. Second Edition.

ERIC Educational Resources Information Center

Hatchett, Melvin S.; Zelade, Richard

This document contains a student assignment book with 22 assignments for a course in food service management and a teacher's guide with answers to the assignments and tips on presenting the lessons to which they pertain. The assignments cover the following topics: career opportunities; entering the food service industry; classifications of…

What Shall I Read on Japan? An Introductory Guide. Twelfth Edition.

ERIC Educational Resources Information Center

Marks, Alfred H.

This highly selective annotated list of works may be read with profit by the serious beginning student or casual reader interested in things Japanese. As many entries as possible from the earlier editions have been retained. All new materials cited were reviewed. Included are reference books, guides, fiction, novels, translations, research…

High/Scope Buyer's Guide to Children's Software. 11th Edition.

ERIC Educational Resources Information Center

Hohmann, Charles; And Others

This 11th edition of the High/Scope Buyer's Guide to Children's Software was designed to help teachers, caregivers, and parents make good choices when purchasing software to enhance children's learning. The book consists of an introduction, a chapter on finding the best software, software reviews for 48 different software products. The…

Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption.

PubMed

Johansen, Anne Katrine; Molenaar, Bas; Versteeg, Danielle; Leitoguinho, Ana Rita; Demkes, Charlotte; Spanjaard, Bastiaan; de Ruiter, Hesther; Akbari Moqadam, Farhad; Kooijman, Lieneke; Zentilin, Lorena; Giacca, Mauro; van Rooij, Eva

2017-10-27

CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)-based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although CRISPR/Cas9 has been extensively used to manipulate the germline in zygotes, its application in postnatal gene editing remains incompletely characterized. To evaluate the feasibility of CRISPR/Cas9-based cardiac genome editing in vivo in postnatal mice. We generated cardiomyocyte-specific Cas9 mice and demonstrated that Cas9 expression does not affect cardiac function or gene expression. As a proof-of-concept, we delivered short guide RNAs targeting 3 genes critical for cardiac physiology, Myh6 , Sav1 , and Tbx20 , using a cardiotropic adeno-associated viral vector 9. Despite a similar degree of DNA disruption and subsequent mRNA downregulation, only disruption of Myh6 was sufficient to induce a cardiac phenotype, irrespective of short guide RNA exposure or the level of Cas9 expression. DNA sequencing analysis revealed target-dependent mutations that were highly reproducible across mice resulting in differential rates of in- and out-of-frame mutations. Finally, we applied a dual short guide RNA approach to effectively delete an important coding region of Sav1 , which increased the editing efficiency. Our results indicate that the effect of postnatal CRISPR/Cas9-based cardiac gene editing using adeno-associated virus serotype 9 to deliver a single short guide RNA is target dependent. We demonstrate a mosaic pattern of gene disruption, which hinders the application of the technology to study gene function. Further studies are required to expand the versatility of CRISPR/Cas9 as a robust tool to study novel cardiac gene functions in vivo. © 2017 American Heart Association, Inc.

Transportation Statistics Annual Report, 2017

DOT National Transportation Integrated Search

2018-01-01

The Transportation Statistics Annual Report describes the Nations transportation system, : the systems performance, its contributions to the economy, and its effects on people and the environment. This 22nd edition of the report is based on inf...

Concepts, The Journal of Defense Systems Acquisition Management. Spring 1982, Volume 5, Number 2. Two Perspectives on Multiyear Procurement European Overview Part II Competition: Does It Lower Costs?

DTIC Science & Technology

1982-01-01

that gained widest acceptance was Abraham Maslow’s hierarchy of human needs.2 His theory was based on two simple premises: People have many needs, and...an Industrial Civilization, 2nd Edition, Boston, Harvard University, 1946. 2. Abraham Maslow , Motivation and Personality, New York, Harper & Bros...management theories to use as a basis for developing their own management approach. The author discusses some of the management theories that have been

Operations. Unit 21. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-21.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on operations in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Be a Choosy Chewer. Nutrition Comes Alive. Level 2. Nutrition Educator's Guide and Work Sheets, Letters to Parents, Recipes. Revised Edition.

ERIC Educational Resources Information Center

Thonney, Patricia; Mapes, Martha C.

This guide provides a nutrition education program for elementary school students that spans kindergarten through Grade 3 as well as providing activities for specific levels. Nutrition education objectives are stated for each grade level: (1) kindergarten--students will become familiar with and motivated to eat a variety of foods; (2) grade…

Record Keeping. Unit 17. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-17.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on recordkeeping in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Financial Analysis. Unit 18. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-18.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on financial analysis in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for…

Business Opportunities. Unit 3. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-3.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on business opportunities in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning…

Marketing Analysis. Unit 8. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-8.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on marketing analysis in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for…

Selling. Unit 16. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-16.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on selling in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a business…

Location. Unit 9. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-09.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on locating a business in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for…

Promotion. Unit 15. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-15.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on promotion in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

A Guide for Parents and Families about What Your 2nd Grader Should Be Learning in School This Year. Don't Fail Your Children.

ERIC Educational Resources Information Center

South Carolina State Education Oversight Committee, Columbia.

This guide shares information about the South Carolina Curriculum Standards with parents. The standards outline state requirements for children's learning, and what students across the state should be able to do in certain subjects. The guide lists seven key reasons for parents to be aware of the new curriculum standards, and then presents a…

Beyond Hate: Countering Violent Extremism from the White Power Movement

DTIC Science & Technology

2013-09-01

Wilson, J. C. Lester, and Walter Lynwood Fleming, Ku Klux Klan Its Origin, Growth and Disbandment, n.d., Kindle edition, loc 109 of 2871. 40...Chalmers, Hooded Americanism, 16–17. 41 Wilson, Lester, and Fleming, Ku Klux Klan Its Origin, Growth and Disbandment, Kindle edition, loc 153 of 2871...Lester, and Fleming, Ku Klux Klan Its Origin, Growth and Disbandment, loc 152 of 2871; Annie Cooper Burton, The Ku Klux Klan (Los Angeles, California

The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate

PubMed Central

Mooers, Blaine H.M.; Singh, Amritanshu

2011-01-01

Guide RNAs bind antiparallel to their target pre-mRNAs to form editing substrates in reaction cycles that insert or delete uridylates (Us) in most mitochondrial transcripts of trypanosomes. The 5′ end of each guide RNA has an anchor sequence that binds to the pre-mRNA by base-pair complementarity. The template sequence in the middle of the guide RNA directs the editing reactions. The 3′ ends of most guide RNAs have ∼15 contiguous Us that bind to the purine-rich unedited pre-mRNA upstream of the editing site. The resulting U-helix is rich in G·U wobble base pairs. To gain insights into the structure of the U-helix, we crystallized 8 bp of the U-helix in one editing substrate for the A6 mRNA of Trypanosoma brucei. The fragment provides three samples of the 5′-AGA-3′/5′-UUU-3′ base-pair triple. The fusion of two identical U-helices head-to-head promoted crystallization. We obtained X-ray diffraction data with a resolution limit of 1.37 Å. The U-helix had low and high twist angles before and after each G·U wobble base pair; this variation was partly due to shearing of the wobble base pairs as revealed in comparisons with a crystal structure of a 16-nt RNA with all Watson–Crick base pairs. Both crystal structures had wider major grooves at the junction between the poly(U) and polypurine tracts. This junction mimics the junction between the template helix and the U-helix in RNA-editing substrates and may be a site of major groove invasion by RNA editing proteins. PMID:21878548

Journal of Special Operations Medicine, Volume 6, Edition 4

DTIC Science & Technology

2006-01-01

units and our active editorial consultants. 2) SOMA members receive the JSOM as part of membership. Please note, if you are a SOMA member and are...directed by the Commander. As of September, the SOF Warrior, Program Executive Office (PEO) has an active and forward moving TC3 program that will...AFSOC medics have been actively deployed around the world. The 352nd Special Operations Group (SOG) medics support- ed a humanitarian non-combatant

Area Handbook Series. Uganda: A Country Study, 2nd Edition

DTIC Science & Technology

1992-01-01

groups in each of these categories, their different responses to the colonial experience, and the impact of world religions. xxi | I I--A Uganda had...government and private-sector initiatives to reduce the rate of transmission and the impact of the disease. In 1991 the internationally funded AIDS...created a moving "ivory frontier" as elephant herds near the coast were nearly exterminated. Leading large caravans financed by Indian moneylenders

Is Visual Imagery Really Visual? Overlooked Evidence from Neuropsychology.

DTIC Science & Technology

1987-08-07

the study of imagery. British Journal of Psychology, 47 101-114 Bauer,R. M.. & Rubens. A B (1985). Agnosia In K. M. Heilman & E. Valenstein (Ed Clinical...Neuropsychology. New York: Oxford University Press. 2nd edition. Beauvois. M.F . & Saillant. B (1985) Optic aphasia for colours and colour agnosia A...integrative visual agnosia . Brain, Roland. P.E. (1982). Cortical regulation of selective attention in man. Journal of Neuroohysiology, 48. 1059-1078

The Response of Nitrifying Bacteria to Treatments of N-Serve and Roundup in Continuous-Flow Soil Columns

DTIC Science & Technology

1988-07-15

Science Society of America, Inc. Atlas , R. V. and R. Bartha . 1987. Microbial Ecology : Fundamentale and Applications, 2nd Edition. Benjamin/Cuynmings...Thompson and Troeh, 1978). However, many nutrient cycling pathways are mediated by only a few genera of bacteria ( Atlas and Bartha , 1987). So...mole of ammonium and nitrite oxidized, respectively ( Atlas and Bartha , 1987). Therefore, large amounts of substrate must be oxidized to provide

No-Regrets Remodeling, 2nd Edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2013-12-01

No-Regrets Remodeling, sponsored by Oak Ridge National Laboratory, is an informative publication that walks homeowners and/or remodelers through various home remodeling projects. In addition to remodeling information, the publication provides instruction on how to incorporate energy efficiency into the remodeling process. The goal of the publication is to improve homeowner satisfaction after completing a remodeling project and to provide the homeowner with a home that saves energy and is comfortable and healthy.

Teaching AIDS. A Resource Guide on Acquired Immune Deficiency Syndrome. Third Edition.

ERIC Educational Resources Information Center

Quackenbush, Marcia; Sargent, Pamela

The first edition of this resource guide for educators on how to teach students about Acquired Immune Deficiency Syndrome (AIDS) was published in 1986. Since then, basic facts about the transmission and prevention of the AIDS virus have not changed substantially. The terminologies about the disease, however, have changed and the changing…

Introduction to Natural Resources. Third Edition. Teacher Edition [and] Student Guide [and] Student Workbook.

ERIC Educational Resources Information Center

Hehn, Darold; Newport, Bob

These student and teacher guides are designed for a secondary-level course in natural resources that focuses on renewable and nonrenewable natural resources, methods of protecting the environment, and the various careers and technologies available in the natural resources area. The following topics are covered in the course's 10 units: outdoor…

The Guide to Simulations/Games For Education and Training. Second Edition.

ERIC Educational Resources Information Center

Zuckerman, David W.; Horn, Robert E.

This guide gives complete information on 613 games and simulation games. In addition, there is a supplementary list of 473 more items which are in development, discontinued, or about which more information is needed. The book is edited for the potential game user, rather than the theoretician or creator. Games are organized by subject, including…

Encountering the Chinese: A Guide for Americans. Second Edition. The InterAct Series.

ERIC Educational Resources Information Center

Wenzhong, Hu; Grove, Cornelius L.

This book provides a practical and culturally sensitive guide to Chinese culture along with insights into how to communicate with and interact with Chinese people. This edition contains information on economic changes and the gradual demise of state owned companies in addition to information about basic Chinese values, cultural norms, and…

Insider's Guide to Graduate Programs in Clinical and Counseling Psychology. 2006/2007 Edition

ERIC Educational Resources Information Center

Mayne, Tracy J.; Norcross, John C.; Sayette, Michael A.

2006-01-01

Now in its 2006-2007 edition, this perennial bestseller is the resource students count on for the most current information on applying to doctoral programs in clinical or counseling psychology. The Insider's Guide presents up-to-date facts on 300 accredited programs in the United States and Canada. Each program's profile includes admissions…

Action Research: An Educational Leader's Guide to School Improvement. Second Edition.

ERIC Educational Resources Information Center

Glanz, Jeffrey

This book, in its second edition, is intended as a practical guide to conducting action research in schools--it outlines the process of designing and reporting an action research project. Contending that action research can be used as a powerful tool that can contribute to school renewal and instructional improvement, the book defines and presents…

Guided Research in Middle School: Mystery in the Media Center. Second Edition

ERIC Educational Resources Information Center

Harrington, LaDawna

2011-01-01

A little imagination, a little drama, a little mystery. Using the guided inquiry model in this updated, second edition, students become detectives at Information Headquarters. They solve a mystery-and enhance their problem-solving and literacy skills. Middle school is a crucial time in the development of problem-solving, critical-thinking, and…

Using Technology with Classroom Instruction that Works. Second Edition

ERIC Educational Resources Information Center

Kuhn, Matt; Hubbell, Elizabeth R.; Pitler, Howard

2012-01-01

If you've upgraded to the second edition of the landmark book "Classroom Instruction That Works," you need this companion guide to help you use technology to support research-based instruction. The authors follow the revised Instructional Planning Guide that makes it easier for you to know when to emphasize each of the instructional strategies,…

Teaching Texas History: An All-Level Resource Guide. Second Revised Edition.

ERIC Educational Resources Information Center

De Boe, David C.

This annotated resource guide offers scores of teaching aids to enrich the teaching of Texas history and geography. This edition differs from its predecessors in several ways: videocassettes replaced the section on 16mm films; the section on "Traveling Museum Exhibits" was dropped because the items were too costly for use in the typical…

The Read-Aloud Handbook. Fourth Edition. Revised and Updated.

ERIC Educational Resources Information Center

Trelease, Jim

This new edition of a guide which has made reading aloud a special pleasure for millions of people offers a chance for a new generation of parents, teachers, grandparents, and siblings to discover the rewards--and the necessity--of reading aloud. The guide provides an up-to-date annotated bibliography ("treasury") of more than 1200…

The Chicago Handbook for Teachers: A Practical Guide to the College Classroom. Second Edition

ERIC Educational Resources Information Center

Brinkley, Alan; El-Fakahany, Esam; Dessants, Betty; Flamm, Michael; Forcey, Charles B., Jr.; Ouellett, Mathew L.; Rothschild, Eric

2011-01-01

Those who teach college students have extensive training in their disciplines, but unlike their counterparts at the high school or elementary school level, they often have surprisingly little instruction in the craft of teaching itself. "The Chicago Handbook for Teachers, Second Edition", is an extraordinarily helpful guide for anyone facing the…

The Humanities: A Selective Guide to Information Sources. Fifth Edition. Library and Information Science Text Series.

ERIC Educational Resources Information Center

Blazek, Ron; Aversa, Elizabeth

This book provides a guide to humanities information sources for teachers and students in schools of library and information science, reference librarians, collection development officers in libraries, humanities scholars, and others who have information needs in the broad discipline. This fifth edition represents a more comprehensive and updated…

Advanced Placement Computer Science (with Pascal). Teacher's Guide. Volume 1. Second Edition.

ERIC Educational Resources Information Center

Farkouh, Alice; And Others

The purpose of this guide is to give teachers and supervisors a working knowledge of various approaches to enhancing pupil learning about computer science, particularly through the use of Pascal. It contains instructional units dealing with: (1) computer components; (2) computer languages; (3) compilers; (4) essential features of a Pascal program;…

Metrication. A Guide for Consumers. Consumer Research Report No. 2. Third Edition.

ERIC Educational Resources Information Center

Consumer and Corporate Affairs Dept., Ottawa (Ontario).

Designed to introduce the metric system to consumers, this guide, developed in Canada, offers a brief definition and history of the metric system and rationale for change. The conversion experiences of other countries are described, and questions about learning the new system and problems involved with the conversion process are also considered.…

The Caring Teacher's Guide to Discipline: Helping Young Students Learn Self-Control, Responsibility, and Respect. Second Edition.

ERIC Educational Resources Information Center

Gootman, Marilyn E.

This book provides a comprehensive guide to teaching students to do the right thing. After "Introduction: Caring Teachers Can Make a Difference," 11 chapters include: (1) "Setting the Stage for Appropriate Behavior"; (2) "Expectations, Limits, and Rules" (unreasonable barricades and how to build moderate fences); (3)…

U.S. Army War College Guide to National Security Issues. Third Edition, Volume 2. National Security Policy and Strategy

DTIC Science & Technology

2008-06-01

183 14. Ethical Issues in War: An Overview Martin L. Cook...185 15. Ethics and War in Comparative Religious Perspective...be guided by values and ethics with the intent of doing some type of good for parts of the international system, or the overall system in general

A Brief Illustrated Guide to Understanding Islam. Second Edition.

ERIC Educational Resources Information Center

Ibrahim, I. A.

This book is a brief guide to understanding Islam, intended to help individuals better understand Islamic culture, Muslims, and the Holy Quran. It consists of the following three chapters: (1) Some Evidence for the Truth of Islam; (2) Some Benefits of Islam; and (3) General Information on Islam. The book is extensively illustrated with photographs…

Special Concretes and Field Problems; Instructor's Guide; Pilot Program Edition.

ERIC Educational Resources Information Center

Portland Cement Association, Cleveland, OH.

This guide, prepared for a 2-year program in junior colleges and technical institutes, is designed for a national program to train persons for employment as technicians in the cement and concrete industries. Included are 48 session oultines divided into four units of study. Each unit contains session objectives and outlines, presentation outlines,…

Jelly Jam, the People Preserver. Teaching Guide. An Environmental Manual for Teachers and Parents. Revised Edition.

ERIC Educational Resources Information Center

Friedman, Judi

Designed for teachers of students in grades 2 through 4, this teaching guide for a self-teaching, interdisciplinary reading and activity program comprises a complete supplemental reading, science, and social studies approach to the problems of environmental pollution. Jelly Jam, a caring little animal, helps children understand how air, water, and…

Maxwell Air Force Base

Science.gov Websites

Social Media Guide (PDF) USAF Social Media Sites 42nd Medical Group 42nd Medical Group Voting Assistance : Open 24 hours a day, seven days a week. - Kelly St. Gate: Open Mon-Fri, 6:00 a.m. - 6 p.m., closed weekends, holidays and AETC down days. - Day St. Gate: Open Mon-Fri, 6:00 a.m. - 2:00 p.m. inbound traffic

Capable Reader Program: Lesson Plan Guide. Units B1; B2; B3; [and] B4. Pilot Year 1979-1980, Final Edition 1980-1981.

ERIC Educational Resources Information Center

Casper, Donna; And Others

Part of a curriculum series for academically gifted elementary students in the area of reading, the four lesson plan guides each fucus on one of the following major objectives: (1) identifying the relationship between the major and minor premise and stating whether the conclusion is a fallacy in reasoning; (2) recognizing the pursuasive use of…

Pricing Strategy. Unit 10. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-10.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on pricing strategy in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Global Markets. Unit 4. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-04.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on global markets in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Legal Issues. Unit 12. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-12.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on legal issues in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Help for the Entrepreneur. Unit 6. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-06.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on help for entrepreneurs in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning…

Your Potential as an Entrepreneur. Unit 1. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-01. Series No. 302-01.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on entrepreneurship potential in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of…

Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

PubMed

Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

2011-03-01

Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.

PubMed

Zuo, Erwei; Cai, Yi-Jun; Li, Kui; Wei, Yu; Wang, Bang-An; Sun, Yidi; Liu, Zhen; Liu, Jiwei; Hu, Xinde; Wei, Wei; Huo, Xiaona; Shi, Linyu; Tang, Cheng; Liang, Dan; Wang, Yan; Nie, Yan-Hong; Zhang, Chen-Chen; Yao, Xuan; Wang, Xing; Zhou, Changyang; Ying, Wenqin; Wang, Qifang; Chen, Ren-Chao; Shen, Qi; Xu, Guo-Liang; Li, Jinsong; Sun, Qiang; Xiong, Zhi-Qi; Yang, Hui

2017-07-01

The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-edited animals showed mosaicism, with editing occurring only in a portion of cells. Here we show that single gene or multiple genes can be completely knocked out in mouse and monkey embryos by zygotic injection of Cas9 mRNA and multiple adjacent single-guide RNAs (spaced 10-200 bp apart) that target only a single key exon of each gene. Phenotypic analysis of F0 mice following targeted deletion of eight genes on the Y chromosome individually demonstrated the robustness of this approach in generating knockout mice. Importantly, this approach delivers complete gene knockout at high efficiencies (100% on Arntl and 91% on Prrt2) in monkey embryos. Finally, we could generate a complete Prrt2 knockout monkey in a single step, demonstrating the usefulness of this approach in rapidly establishing gene-edited monkey models.

Iowa Acceleration Scale Manual: A Guide for Whole-Grade Acceleration K-8. (3rd Edition, Manual)

ERIC Educational Resources Information Center

Assouline, Susan G.; Colangelo, Nicholas; Lupkowski-Shoplik, Ann; Forstadt, Leslie; Lipscomb, Jonathon

2009-01-01

Feedback from years of nationwide use has resulted in a 3rd Edition of this unique, systematic, and objective guide to considering and implementing academic acceleration. Developed and tested by the Belin-Blank Center at the University of Iowa, the IAS ensures that acceleration decisions are systematic, thoughtful, well reasoned, and defensible.…

The Copyright Book: A Practical Guide. Fourth Edition.

ERIC Educational Resources Information Center

Strong, William S.

In response to important changes in copyright law as the United States accommodates itself to the Berne Convention and develops means to take account of new technologies, this guide puts these changes in a form and context that will make sense to persons who are concerned about their rights under the law. New material in the fourth edition of this…

The Newbery and Caldecott Awards: A Guide to the Medal and Honor Books. 2012 Edition

ERIC Educational Resources Information Center

ALA Editions, 2012

2012-01-01

Updated to include the 2012 award and honor books, this new edition of the annual guide to the Newbery and Caldecott awards gathers together the books deemed most distinguished in American children's literature and illustration since the inception of the renowned prizes. Librarians and teachers everywhere rely on this guidebook for quick reference…

A Teacher's Guide to Including Students with Disabilities in General Physical Education, Third Edition

ERIC Educational Resources Information Center

Block, Martin E.

2007-01-01

This book, provides a comprehensive guide to making phys. ed. inclusion work for students of all ages. In this new edition of the trusted bestseller, renowned expert Martin E. Block and a select group of highly respected contributors provide: (1) new information reflecting all the latest updates to IDEA, other disability-related legislation, and…

Production of Purified CasRNPs for Efficacious Genome Editing.

PubMed

Lingeman, Emily; Jeans, Chris; Corn, Jacob E

2017-10-02

CRISPR-Cas systems have been harnessed as modular genome editing reagents for functional genomics and show promise to cure genetic diseases. Directed by a guide RNA, a Cas effector introduces a double stranded break in DNA and host cell DNA repair leads to the introduction of errors (e.g., to knockout a gene) or a programmed change. Introduction of a Cas effector and guide RNA as a purified Cas ribonucleoprotein complex (CasRNP) has recently emerged as a powerful approach to alter cell types and organisms. Not only does CasRNP editing exhibit increased efficacy and specificity, it avoids optimization and iteration of species-specific factors such as codon usage, promoters, and terminators. CasRNP editing has been rapidly adopted for research use in many contexts and is quickly becoming a popular method to edit primary cells for therapeutic application. This article describes how to make a Cas9 RNP and outlines its use for gene editing in human cells. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

xLPR Sim Editor 1.0 User's Guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mariner, Paul E.

2017-03-01

The United States Nuclear Regulatory Commission in cooperation with the Electric Power Research Institute contracted Sandia National Laboratories to develop the framework of a probabilistic fracture mechanics assessment code called xLPR ( Extremely Low Probability of Rupture) Version 2.0 . The purpose of xLPR is to evaluate degradation mechanisms in piping systems at nuclear power plants and to predict the probability of rupture. This report is a user's guide for xLPR Sim Editor 1.0 , a graphical user interface for creating and editing the xLPR Version 2.0 input file and for creating, editing, and using the xLPR Version 2.0 databasemore » files . The xLPR Sim Editor, provides a user - friendly way for users to change simulation options and input values, s elect input datasets from xLPR data bases, identify inputs needed for a simulation, and create and modify an input file for xLPR.« less

Linking measures of adolescent nicotine dependence to a common latent continuum.

PubMed

Strong, David R; Kahler, Christopher W; Colby, Suzanne M; Griesler, Pamela C; Kandel, Denise

2009-01-01

Using the theoretical model of nicotine dependence (ND) operationalized within the Diagnostic and Statistical Manual of Mental Disorder, fourth Edition (DSM-IV: American Psychiatric [American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association, Washington, DC]) as a frame of reference, we used methods based in item response theory to link alternative instruments assessing adolescent nicotine dependence severity to a common latent continuum. A multi-ethnic cohort of 6th-10th graders selected from the Chicago Public Schools (CPS) completed five household interviews over 2 years. Youth who reported at least some cigarette use in the last 30 days prior to the interviews at waves W3-W5 completed measures of DSM-IV ND, the Modified Fagertrom Tolerance Questionnaire (mFTQ: Prokhorov et al., 1998) and the Nicotine Dependence Syndrome Scale (NDSS: Shiffman et al., 2004), yielding samples of 253, 241, and 296 respondents at W3-W5, respectively. Confirmatory factor analysis supported a primary dimension of ND. Each instrument's items had complementary and stable relationships to ND across multiple waves of assessment. By aligning symptoms along a common latent ND continuum, we evaluated the consistency of symptoms from different instruments that target similar content. Further, these methods allowed for the examination of the DSM-IV as a continuous index of ND, evaluation of the degree of heterogeneity in levels of ND within groups above and below diagnostic thresholds, and the utility of using the pattern or particular DSM-IV symptoms that led to each score in further differentiating levels of ND. Finally, we examined concurrent validity of the ND continuum and levels of current of smoking at each wave of assessment.

Investigating the Acquisition of Software Systems that Rely on Open Architecture and Open Source Software

DTIC Science & Technology

2010-03-01

associated with certain software systems [Breaux and Anton 2008]. With this basis to build on, it is now possible to analyze the alignment of...Kazman, R., (2003). Software Architecture in Practice, 2nd Edition, Addison-Wesley Pro- fessional, New York.. Breaux, T.D. and Anton , A.I. (2008... calculus for license rights and obligations in license and context models. Using them, we calculate rights and obligations for specific sys- tems, identify

Fidelity of DNA Replication in Normal and Malignant Human Breast Cells.

DTIC Science & Technology

1997-08-01

enzyme) into the multiple cloning site (MCS). This template will not only replicate inside a mammalian cell (utilizing the E-B virus origin), and...Maniatis, T. Commonly used techniques in molecular cloning . In: Molecular cloning : REFERENCES a laboratory manual, 2nd edition. Cold Spring Harbor...A vatit"Y Of DNA synthesis and the typt of DNA replica~tion Products " celular prca including DNA rsplicatlon. DNA repsair. R~NA formed in experiments

An Examination of Referral Physician Attitudes Toward Brooke Army Medical Center as a Tertiary Care Medical Center

DTIC Science & Technology

1986-09-01

William B. Handbook in Research and Evaluation. San Diego: Edits Publishers, 1977. Kotler , Philip . Marketing for Nonprofit Organizations. 2nd ed. Englewood...Marketing and the Regional Model." Hospital & Health Services Administration 28 (May-June 1983): p. 65. 18 Philip D. Cooper and Larry M. Robinson...34 Hospital & Health Services Administration 23 (Winter 1978): p. 11. 20 Philip 0. Cooper and Larry M. Robinson, Health Care Marketing Management, pp

Development of CRISPR/Cas9 mediated virus resistance in agriculturally important crops.

PubMed

Khatodia, Surender; Bhatotia, Kirti; Tuteja, Narendra

2017-05-04

Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR associated nuclease 9 (Cas9) system of targeted genome editing has already revolutionized the plant science research. This is a RNA guided programmable endonuclease based system composed of 2 components, the Cas9 nuclease and an engineered guide RNA targeting any DNA sequence of the form N20-NGG for novel genome editing applications. The CRISPR/Cas9 technology of targeted genome editing has been recently applied for imparting virus resistance in plants. The robustness, wide adaptability, and easy engineering of this system has proved its potential as an antiviral tool for plants. Novel DNA free genome editing by using the preassembled Cas9/gRNA ribonucleoprotein complex for development of virus resistance in any plant species have been prospected for the future. Also, in this review we have discussed the reports of CRISPR/Cas9 mediated virus resistance strategy against geminiviruses by targeting the viral genome and transgene free strategy against RNA viruses by targeting the host plant factors. In conclusion, CRISPR/Cas9 technology will provide a more durable and broad spectrum viral resistance in agriculturally important crops which will eventually lead to public acceptance and commercialization in the near future.

The effects of Nd2O3 concentration in the laser emission of TeO2-ZnO glasses

NASA Astrophysics Data System (ADS)

Moreira, L. M.; Anjos, V.; Bell, M. J. V.; Ramos, C. A. R.; Kassab, L. R. P.; Doualan, D. J. L.; Camy, P.; Moncorgé, R.

2016-08-01

The present work reports the modification introduced by different Nd2O3 concentration on optical properties and the laser operation of Nd3+ doped (TeO2-ZnO) bulk tellurite glass. The spectroscopic data are analyzed within the Judd Ofelt formalism framework and the results are compared to the fluorescence lifetime and emission measurements to derive values for the quantum efficiency and the stimulated emission cross section of the considered 4F3/2 → 4I11/2 infrared laser transition around 1062.5 nm. Continuous-wave laser action is achieved with this bulk tellurite glass by pumping the sample inside a standard plan-concave mirror laser cavity with different output couplers. It is possible to observe coherent emission only for the lower concentration (0.5%(wt.) of Nd2 O3). Also laser action could only be observed for this sample with threshold pump power of 73 mW associated with a laser slope efficiency of 8% for an output coupler transmission of 4% indicating that TeO2-ZnO are potential materials for laser action. The results presented in this work together with those previously reported with higher concentration (1.0% (wt) of Nd2O3) determine the adequate Nd2O3 concentration for laser action and guide the correct experimental procedure for TeO2-ZnO glasses preparation.

Book Review: Reiner Salzer and Heinz W. Siesler (Eds.): Infrared and Raman spectroscopic imaging, 2nd ed.

DOE PAGES

Moore, David Steven

2015-05-10

This second edition of "Infrared and Raman Spectroscopic Imaging" propels practitioners in that wide-ranging field, as well as other readers, to the current state of the art in a well-produced and full-color, completely revised and updated, volume. This new edition chronicles the expanded application of vibrational spectroscopic imaging from yesterday's time-consuming point-by-point buildup of a hyperspectral image cube, through the improvements afforded by the addition of focal plane arrays and line scan imaging, to methods applicable beyond the diffraction limit, instructs the reader on the improved instrumentation and image and data analysis methods, and expounds on their application to fundamentalmore » biomedical knowledge, food and agricultural surveys, materials science, process and quality control, and many others.« less

Effects of a Home-Based Family-Centred Early Habilitation Program on Neurobehavioural Outcomes of Very Preterm Born Infants: A Retrospective Cohort Study

PubMed Central

Poggioli, Michela; Minichilli, Fabrizio; Bononi, Tiziana; Meghi, Pasquina; Andre, Paolo; Crecchi, Alessandra; Rossi, Bruno; Carboncini, Maria Chiara; Ottolini, Alberto

2016-01-01

Preterm children have an increased risk of neurodevelopmental impairments which include psychomotor and language retardation. The objectives of the present retrospective cohort study were to examine the effects of an individually adapted, home-based, and family-centred early developmental habilitation program on neurodevelopmental and behavioural outcomes of very preterm children compared with a standard follow-up at 2 years' corrected age. Enrolled infants were retrospectively assigned to the intervention group (61 subjects) or to the control group (62 subjects) depending on whether they had or had not carried out a home-based family-centred early developmental habilitation program focused on environmental enrichment, parent-guided environmental interaction, and infant development. Developmental outcome was assessed for both groups at 24 months' corrected age using the Bayley Scales of Infant Development 2nd Edition. Intervention significantly improved both cognitive and behavioural outcomes. In addition, males had significantly lower scores than females either before or after treatment. However, the treatment was effective in both genders to the same extent. In conclusion, a timely updated environment suitable to the infant's developmental needs could provide the best substrate where the parent-infant relationship can be practised with the ultimate goal of achieving further developmental steps. PMID:28090357

Effects of a Home-Based Family-Centred Early Habilitation Program on Neurobehavioural Outcomes of Very Preterm Born Infants: A Retrospective Cohort Study.

PubMed

Poggioli, Michela; Minichilli, Fabrizio; Bononi, Tiziana; Meghi, Pasquina; Andre, Paolo; Crecchi, Alessandra; Rossi, Bruno; Carboncini, Maria Chiara; Ottolini, Alberto; Bonfiglio, Luca

2016-01-01

Preterm children have an increased risk of neurodevelopmental impairments which include psychomotor and language retardation. The objectives of the present retrospective cohort study were to examine the effects of an individually adapted, home-based, and family-centred early developmental habilitation program on neurodevelopmental and behavioural outcomes of very preterm children compared with a standard follow-up at 2 years' corrected age. Enrolled infants were retrospectively assigned to the intervention group (61 subjects) or to the control group (62 subjects) depending on whether they had or had not carried out a home-based family-centred early developmental habilitation program focused on environmental enrichment, parent-guided environmental interaction, and infant development. Developmental outcome was assessed for both groups at 24 months' corrected age using the Bayley Scales of Infant Development 2nd Edition. Intervention significantly improved both cognitive and behavioural outcomes. In addition, males had significantly lower scores than females either before or after treatment. However, the treatment was effective in both genders to the same extent. In conclusion, a timely updated environment suitable to the infant's developmental needs could provide the best substrate where the parent-infant relationship can be practised with the ultimate goal of achieving further developmental steps.

PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.

PubMed

Mehanna, Hisham; McConkey, Chris C; Rahman, Joy K; Wong, Wai-Lup; Smith, Alison F; Nutting, Chris; Hartley, Andrew Gj; Hall, Peter; Hulme, Claire; Patel, Dharmesh K; Zeidler, Sandra Ventorin von; Robinson, Max; Sanghera, Bal; Fresco, Lydia; Dunn, Janet A

2017-04-01

Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)-computerised tomography (CT) scanning demonstrated high negative predictive values for persistent nodal disease, providing a possible alternative paradigm to ND. Evidence is sparse and drawn mainly from retrospective single-institution studies, illustrating the need for a prospective randomised controlled trial. To determine the efficacy and cost-effectiveness of PET-CT-guided surveillance, compared with planned ND, in a multicentre, prospective, randomised setting. A pragmatic randomised non-inferiority trial comparing PET-CT-guided watch-and-wait policy with the current planned ND policy in HNSCC patients with locally advanced nodal metastases and treated with radical CRT. Patients were randomised in a 1 : 1 ratio. Primary outcomes were overall survival (OS) and cost-effectiveness [incremental cost per incremental quality-adjusted life-year (QALY)]. Cost-effectiveness was assessed over the trial period using individual patient data, and over a lifetime horizon using a decision-analytic model. Secondary outcomes were recurrence in the neck, complication rates and quality of life. The recruitment of 560 patients was planned to detect non-inferior OS in the intervention arm with a 90% power and a type I error of 5%, with non-inferiority defined as having a hazard ratio (HR) of no higher than 1.50. An intention-to-treat analysis was performed by Cox's proportional hazards model. Thirty-seven head and neck cancer-treating centres (43 NHS hospitals) throughout the UK. Patients with locally advanced nodal metastases of oropharynx, hypopharynx, larynx, oral or occult HNSCC receiving CRT and fit for ND were recruited. Patients randomised to planned ND before or after CRT (control), or CRT followed by fludeoxyglucose PET-CT 10-12 weeks post CRT with ND only if PET-CT showed incomplete or equivocal response of nodal disease (intervention). Balanced by centre, planned ND timing, CRT schedule, disease site and the tumour, node, metastasis stage. In total, 564 patients were recruited (ND arm, n  = 282; and surveillance arm, n  = 282; 17% N2a, 61% N2b, 18% N2c and 3% N3). Eighty-four per cent had oropharyngeal cancer. Seventy-five per cent of tested cases were p16 positive. The median time to follow-up was 36 months. The HR for OS was 0.92 [95% confidence interval (CI) 0.65 to 1.32], indicating non-inferiority. The upper limit of the non-inferiority HR margin of 1.50, which was informed by patient advisors to the project, lies at the 99.6 percentile of this estimate ( p  = 0.004). There were no differences in this result by p16 status. There were 54 NDs performed in the surveillance arm, with 22 surgical complications, and 221 NDs in the ND arm, with 85 complications. Quality-of-life scores were slightly better in the surveillance arm. Compared with planned ND, PET-CT surveillance produced an incremental net health benefit of 0.16 QALYs (95% CI 0.03 to 0.28 QALYs) over the trial period and 0.21 QALYs (95% CI -0.41 to 0.85 QALYs) over the modelled lifetime horizon. Pragmatic randomised controlled trial with a 36-month median follow-up. PET-CT-guided active surveillance showed similar survival outcomes to ND but resulted in considerably fewer NDs, fewer complications and lower costs, supporting its use in routine practice. PET-CT surveillance is cost-effective in the short term, and long-term cost-effectiveness could be addressed in future work. Current Controlled Trials ISRCTN13735240. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment ; Vol. 21, No. 17. See the NIHR Journals Library website for further project information.

Efficient solar-pumped Nd:YAG laser by a double-stage light-guide/V-groove cavity

NASA Astrophysics Data System (ADS)

Almeida, Joana; Liang, Dawei

2011-05-01

Since the first reported Nd:YAG solar laser, researchers have been exploiting parabolic mirrors and heliostats for enhancing laser output performance. We are now investigating the production of an efficient solar-pumped laser for the reduction of magnesium from magnesium oxide, which could be an alternative solution to fossil fuel. Therefore both high conversion efficiency and excellent beam quality are imperative. By using a single fused silica light guide of rectangular cross section, highly concentrated solar radiation at the focal spot of a stationary parabolic mirror is efficiently transferred to a water-flooded V-groove pump cavity. It allows for the double-pass absorption of pump light along a 4mm diameter, 30mm length, 1.1at% Nd:YAG rod. Optimum pumping parameters and solar laser output power are found through ZEMAXTM non-sequential ray-tracing and LASCADTM laser cavity analysis. 11.0 W of multimode laser output power with excellent beam profile is numerically calculated, corresponding to 6.1W/m2 collection efficiency. To validate the proposed pumping scheme, an experimental setup of the double-stage light-guide/V-groove cavity was built. 78% of highly concentrated solar radiation was efficiently transmitted by the fused silica light guide. The proposed pumping scheme can be an effective solution for enhancing solar laser performances when compared to other side-pump configurations.

Operation of Wastewater Treatment Plants: A Field Study Training Program. Volume I, Instructor's Guide. Second Edition.

ERIC Educational Resources Information Center

California State Univ., Sacramento. Dept. of Civil Engineering.

The objective of this instructor's guide is to help provide students with knowledge and skills for employment in the field of wastewater treatment. Included in each chapter outline are: (1) objectives, (2) instructional approach, (3) answers to the objective test in the student's text, and (4) an explanation of these answers. The material…

Operation of Wastewater Treatment Plants: A Field Study Training Program. Volume II, Instructor's Guide. Second Edition.

ERIC Educational Resources Information Center

California State Univ., Sacramento. Dept. of Civil Engineering.

The objective of this instructor's guide is to help provide students with knowledge and skills for employment in the field of wastewater treatment. Included in each chapter outline are: (1) objectives, (2) instructional approach, (3) answers to the objective test in the student's text, and (4) an explanation of these answers. The material…

Let's Go Exploring. Nutrition Comes Alive. Level 1. Nutrition Educator's Guide and Work Sheets, Letters to Parents, Recipes. Revised Edition.

ERIC Educational Resources Information Center

Farrell, Tracy J.

This guide provides a nutrition education program for elementary school students that spans kindergarten through Grade 3 as well as providing activities for specific levels. Nutrition education objectives are stated for each grade level: (1) kindergarten--students will become familiar with and motivated to eat a variety of foods; (2) grade…

The Food Peddlers. Nutrition Comes Alive. Level 3. Nutrition Educator's Guide and Work Sheets, Letters to Parents, Recipes. Revised Edition.

ERIC Educational Resources Information Center

Mapes, Martha C.; Thonney, Patricia

This guide provides a nutrition education program for elementary school students that spans kindergarten through Grade 3 as well as providing activities for specific levels. Nutrition education objectives are stated for each grade level: (1) kindergarten--students will become familiar with and motivated to eat a variety of foods; (2) grade…

Countermeasures That Work : A Highway Safety Countermeasure Guide For State Highway Safety Offices Sixth Edition, 2011

DOT National Transportation Integrated Search

2011-02-01

This edition of Countermeasures that Work was prepared by the University of North Carolina Highway Safety Research Center (HSRC). Researchers who contributed to this edition include Arthur H. Goodwin, Libby J. Thomas, William L. Hall, and Mary Ellen ...

Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map

PubMed Central

Berlyn, Mary K. B.

1998-01-01

This map is an update of the edition 9 map by Berlyn et al. (M. K. B. Berlyn, K. B. Low, and K. E. Rudd, p. 1715–1902, in F. C. Neidhardt et al., ed., Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed., vol. 2, 1996). It uses coordinates established by the completed sequence, expressed as 100 minutes for the entire circular map, and adds new genes discovered and established since 1996 and eliminates those shown to correspond to other known genes. The latter are included as synonyms. An alphabetical list of genes showing map location, synonyms, the protein or RNA product of the gene, phenotypes of mutants, and reference citations is provided. In addition to genes known to correspond to gene sequences, other genes, often older, that are described by phenotype and older mapping techniques and that have not been correlated with sequences are included. PMID:9729611

Refracted Acoustic Communications in Wireless Underwater Sensor Networks with Mobility

DTIC Science & Technology

2015-07-01

presented in ( Nicolaou et al., 2007). Depth measurement ca- pability is assumed in depth-based routing schemes (Hasannezhad et al., 2014). Awareness of...Ri cosαk )2 = (di j Ri tanαk)2+(Δzi j+Ri)2 R2i cos2αk = d2i j 2di jRi tanαk+R 2 i tan 2αk+ . . . (Δzi j)2+2Δzi jRi+R2i Grouping all R2i terms on the...1754–1757. Lurton, X. (2010). An Introduction to Underwater Acoustics. Springer-Verlag, Berlin, 2nd edition. Nicolaou , N., See, A., Cui, J., and

Financing the Business. Unit 11. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-11. Series No. 302-11.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on business financing in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for…

Essential Study Skills: The Complete Guide to Success at University. Second Edition. Sage Study Skills Series

ERIC Educational Resources Information Center

Burns, Tom; Sinfield, Sandra

2008-01-01

The eagerly-awaited new edition of the successful "Essential Study Skills" continues to provide a truly practical guide to achieving success at university. Whether you are going to university straight from school, a mature student, or an overseas student studying in the UK for the first time, this is the book that will help you to better…

Accounting for Independent Schools. Second Edition.

ERIC Educational Resources Information Center

National Association of Independent Schools, Boston, MA.

This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

Annual Editions: Early Childhood Education 06/07

ERIC Educational Resources Information Center

Paciorek, Karen Menke, Ed.

2006-01-01

This 27th edition of "Annual Editions: Early Childhood Education" provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for…

A Mouse Geneticist’s Practical Guide to CRISPR Applications

PubMed Central

Singh, Priti; Schimenti, John C.; Bolcun-Filas, Ewelina

2015-01-01

CRISPR/Cas9 system of RNA-guided genome editing is revolutionizing genetics research in a wide spectrum of organisms. Even for the laboratory mouse, a model that has thrived under the benefits of embryonic stem (ES) cell knockout capabilities for nearly three decades, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 technology enables one to manipulate the genome with unprecedented simplicity and speed. It allows generation of null, conditional, precisely mutated, reporter, or tagged alleles in mice. Moreover, it holds promise for other applications beyond genome editing. The crux of this system is the efficient and targeted introduction of DNA breaks that are repaired by any of several pathways in a predictable but not entirely controllable manner. Thus, further optimizations and improvements are being developed. Here, we summarize current applications and provide a practical guide to use the CRISPR/Cas9 system for mouse mutagenesis, based on published reports and our own experiences. We discuss critical points and suggest technical improvements to increase efficiency of RNA-guided genome editing in mouse embryos and address practical problems such as mosaicism in founders, which complicates genotyping and phenotyping. We describe a next-generation sequencing strategy for simultaneous characterization of on- and off-target editing in mice derived from multiple CRISPR experiments. Additionally, we report evidence that elevated frequency of precise, homology-directed editing can be achieved by transient inhibition of the Ligase IV-dependent nonhomologous end-joining pathway in one-celled mouse embryos. PMID:25271304

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

PubMed

Schiroli, Giulia; Ferrari, Samuele; Conway, Anthony; Jacob, Aurelien; Capo, Valentina; Albano, Luisa; Plati, Tiziana; Castiello, Maria C; Sanvito, Francesca; Gennery, Andrew R; Bovolenta, Chiara; Palchaudhuri, Rahul; Scadden, David T; Holmes, Michael C; Villa, Anna; Sitia, Giovanni; Lombardo, Angelo; Genovese, Pietro; Naldini, Luigi

2017-10-11

Targeted genome editing in hematopoietic stem/progenitor cells (HSPCs) is an attractive strategy for treating immunohematological diseases. However, the limited efficiency of homology-directed editing in primitive HSPCs constrains the yield of corrected cells and might affect the feasibility and safety of clinical translation. These concerns need to be addressed in stringent preclinical models and overcome by developing more efficient editing methods. We generated a humanized X-linked severe combined immunodeficiency (SCID-X1) mouse model and evaluated the efficacy and safety of hematopoietic reconstitution from limited input of functional HSPCs, establishing thresholds for full correction upon different types of conditioning. Unexpectedly, conditioning before HSPC infusion was required to protect the mice from lymphoma developing when transplanting small numbers of progenitors. We then designed a one-size-fits-all IL2RG (interleukin-2 receptor common γ-chain) gene correction strategy and, using the same reagents suitable for correction of human HSPC, validated the edited human gene in the disease model in vivo, providing evidence of targeted gene editing in mouse HSPCs and demonstrating the functionality of the IL2RG -edited lymphoid progeny. Finally, we optimized editing reagents and protocol for human HSPCs and attained the threshold of IL2RG editing in long-term repopulating cells predicted to safely rescue the disease, using clinically relevant HSPC sources and highly specific zinc finger nucleases or CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9). Overall, our work establishes the rationale and guiding principles for clinical translation of SCID-X1 gene editing and provides a framework for developing gene correction for other diseases. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing.

PubMed

Tang, Yan-Dong; Guo, Jin-Chao; Wang, Tong-Yun; Zhao, Kuan; Liu, Ji-Ting; Gao, Jia-Cong; Tian, Zhi-Jun; An, Tong-Qing; Cai, Xue-Hui

2018-03-06

Several groups have used CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) for DNA virus editing. In most cases, one single-guide RNA (sgRNA) is used, which produces inconsistencies in gene editing. In this study, we used a swine herpesvirus, pseudorabies virus, as a model to systematically explore the application of CRISPR/Cas9 in DNA virus editing. In our current report, we demonstrated that cotransfection of 2 sgRNAs and a viral genome resulted in significantly better knockout efficiency than the transfection-infection-based approach. This method could result in 100% knockout of ≤3500 bp of viral nonessential large fragments. Furthermore, knockin efficiency was significantly improved by using 2 sgRNAs and was also correlated with the number of background viruses. We also demonstrated that the background viruses were all 2-sgRNA-mediated knockout mutants. Finally, this study demonstrated that the efficacy of gene knockin is determined by the replicative kinetics of background viruses. We propose that CRISPR/Cas9 coupled with 2 sgRNAs creates a powerful tool for DNA virus editing and offers great potential for future applications.-Tang, Y.-D., Guo, J.-C., Wang, T.-Y., Zhao, K., Liu, J.-T., Gao, J.-C., Tian, Z.-J., An, T.-Q., Cai, X.-H. CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing.

BATTERIES AND BULBS, BOOK 3, CIRCUITS II, TEACHER'S GUIDE.

ERIC Educational Resources Information Center

Elementary Science Study, Newton, MA.

THIS TRIAL EDITION OF A TEACHER'S GUIDE, BOOK III IN A SERIES OF FOUR, IS INTENDED TO PROVIDE RESOURCE MATERIAL FOR AN INTRODUCTORY STUDY OF ELECTRICITY AND MAGNETISM. IT CAN BE USED WITH VARIOUS STUDENT GROUPS FROM GRADES 2 TO 10, AND IN CONJUNCTION WITH THE OTHER BOOKS OF THE SERIES, PROVIDES MATERIALS FOR A PROGRAM OF FROM 5 TO 40 WEEKS,…

SCDC Spanish Curricula Units. Science/Math Strand, Unit 5, Grade 2, Teacher's Guide--Multi-Ethnic Edition.

ERIC Educational Resources Information Center

Operations Research Society of America, Arlington, VA.

Continuing the theme of the school as a community, the teacher's guide to the science/math strand of unit five presents both instructional and assessment activities for kits 17-20. Focus, materials and objective for each activity are in Spanish and English; teacher instructions are in Spanish only. In kit 17 the science activities deal with the…

T-Check in Technologies for Interoperability: Web Services and Security--Single Sign-On

DTIC Science & Technology

2007-12-01

following tools: • Apache Tomcat 6.0—a Java Servlet container to host the Web services and a simple Web client application [Apache 2007a] • Apache Axis...Eclipse. Eclipse – an open development platform. http://www.eclipse.org/ (2007) [Hunter 2001] Hunter, Jason. Java Servlet Programming, 2nd Edition...Citation SAML 1.1 Java Toolkit SAML Ping Identity’s SAML-1.1 implementation [SourceID 2006] OpenSAML SAML An open source implementation of SAML 1.1

Recommendations to Strengthen Civil Society and Balance Michigan's State Budget, 2nd Edition. An Analysis of Fiscal-Year 2003-04 Appropriations and Recommendations for 2004-05. Revision of the March 2003 Study. A Mackinac Center Report

ERIC Educational Resources Information Center

LaFaive, Michael D.

2004-01-01

As the debate rages in Lansing over the size and scope of the 2004-2005 Fiscal Year state budget, the Mackinac Center for Public Policy is republishing and updating budget cutting ideas from its March 2003 study, "Recommendations to Strengthen Civil Society and Balance Michigan's Budget." The 2003 study made over 200 recommendations…

Finite Element and Analytical Analysis of Cracks in Thick Stiffened Plates Repaired with a Single Sided Composite Patch

DTIC Science & Technology

2014-06-01

DC,Tech. Rep. CG-D-05–00, 2000. [16] S. Kou, Welding Metallurgy , 2nd edition, Hoboken: Wiley Interscience, 2003. [17] C. Poe, “Stress intensity...continuous aluminum superstructure welded to the deck. The shape of the superstructure created numerous stress concentration areas. Of the greatest concern...study as it will help provide a conservative estimate. In marine applications almost all stiffening members are attached by welding . Unlike a

Unfinished Business: A Framework for Peace in the Great Lakes (Africa Security Brief, Number 21, July 2012)

DTIC Science & Technology

2012-07-01

where they are levied with fees and re-exported, often by lo- cal businesses. This has become a significant source of economic activity and growth ...Policies for Growth with a Focus on Household Enterprises, Rwanda Economic Update 2 nd Edition, (Washington, DC: World Bank, November 2011), 3. 9 Ivan...extended instability has also led to a collapse of basic social services and economic activ- ity in parts of the Democratic Republic of the Congo

Certification of Public Librarians in the United States; A Detailed Summary of Legal and Voluntary Certification Plans for Public Librarians Based on Information Supplied by the Various Certificating State Agencies or other Appropriate Sources, 2nd Edition.

ERIC Educational Resources Information Center

Frame, Ruth R.; Coyne, John R.

Contained in this report is a detailed summary of legal and voluntary certification plans for public librarians in each of the 50 states. Descriptions of the certification plans for public librarians are based on information supplied by state agencies in September 1971. Each plan is identified by the descriptive terms--mandatory, permissive or…

Using the Internet, Online Services, and CD-ROMs for Writing Research and Term Papers, Second Edition. Neal-Schuman NetGuide Series.

ERIC Educational Resources Information Center

Harmon, Charles, Ed.

Like its predecessor, this second edition combines the best of two traditional generic texts: "how to write a term paper" and "how to use the library." Particularly helpful for high school and first year college students, this guide explains how to utilize online library catalogs, the most commonly available indexes and databases (in print,…

The ABCs of School Choice: The Comprehensive Guide to Every Private School Choice Program in America. 2016 Edition

ERIC Educational Resources Information Center

Friedman Foundation for Educational Choice, 2016

2016-01-01

"The ABCs of School Choice" is a comprehensive, data-rich guide to every private school choice program in America. The 2016 edition of "The ABCs of School Choice" is the best yet, not just because of the new look and the fantastic growth in the number of school choice programs, but also because it is now paired with a…

Fine motor skill proficiency in typically developing children: On or off the maturation track?

PubMed

Gaul, David; Issartel, Johann

2016-04-01

Fine motor skill proficiency is an essential component of numerous daily living activities such as dressing, feeding or playing. Poor fine motor skills can lead to difficulties in academic achievement, increased anxiety and poor self-esteem. Recent findings have shown that children's gross motor skill proficiency tends to fall below established developmental norms. A question remains: do fine motor skill proficiency levels also fall below developmental norms? The aim of this study was to examine the current level of fine motor skill in Irish children. Children (N=253) from 2nd, 4th and 6th grades (mean age=7.12, 9.11 and 11.02 respectively) completed the Fine Motor Composite of the Bruininks Oseretsky Test of Motor Proficiency 2nd Edition (BOT-2). Analysis revealed that only 2nd grade children met the expected level of fine motor skill proficiency. It was also found that despite children's raw scores improving with age, children's fine motor skill proficiency was not progressing at the expected rate given by normative data. This leads us to question the role and impact of modern society on fine motor skills development over the past number of decades. Copyright © 2015 Elsevier B.V. All rights reserved.

[Historical changes in the list of plasma fractionation products placed on the WHO Model List of Essential Medicines].

PubMed

Sakagami, Yuichiro; Tsutani, Kiichiro

2014-01-01

The purpose of this study was to summarize the historical changes in the list of plasma fractionation products (PFP) placed on the Model List of Essential Medicines (EML) issued by the World Health Organization (WHO). PFP such as albumin, blood coagulation factors, and immunoglobulins are derived from blood collected from thousands of people. PFP have been listed since the first edition of the EML (1977). However, the PFP listed on the EML have changed dramatically because EML's selection process has changed from experience-based to evidence-based. For example, albumin, which had been listed since the 2nd edition (1979), was deleted in the 11th edition (2000) because of the uncertainty of its efficacy. Human immunoglobulin normal, which had been deleted from the 13th edition (2003), was relisted in the 15th edition (2007). Moreover, the WHO has issued several resolutions and guidelines regarding PFP production, quality, and safety in order to promote the establishment of blood programmes in every nation. The focus of WHO's EML selection process has changed over 30 years. In the 20th century, WHO mainly focused on PFP efficacy, quality, and safety problems. However, currently the focus is on the problem of PFP accessibility, especially in developing countries. Therefore, it would be important to know how to capitalize on established knowledge and production technology to increase the accessibility of PFP worldwide.

Universal Design in Higher Education: From Principles to Practice. Second Edition

ERIC Educational Resources Information Center

Burgstahler, Sheryl E., Ed.

2015-01-01

This second edition of the classic "Universal Design in Higher Education" is a comprehensive, up-to-the-minute guide for creating fully accessible college and university programs. The second edition has been thoroughly revised and expanded, and it addresses major recent changes in universities and colleges, the law, and technology. As…

Textual Challenges: A Brief Guide to Choosing Shakespearean Editions

ERIC Educational Resources Information Center

Cornell, Christine; Malcolmson, Patrick

2012-01-01

How should educators go about selecting appropriate editions of Shakespeare's plays for use in political science courses? Shakespeare is turning up on many politics syllabi, but, at times, the editions chosen seem to reflect primarily a concern for price or publisher reputation over pedagogical and scholarly considerations. This article offers an…

Introduction to Natural Resources. Second Edition. [Teacher Edition and Student Edition Combined.

ERIC Educational Resources Information Center

Crummett, Dan

These student and teacher guides are designed for a secondary-level course in natural resources that focuses on renewable and nonrenewable natural resources, methods of protecting the environment, and the various careers and technologies available in the natural resources area. The following topics are covered in the course's 10 units: outdoor…

A population study of the minicircles in Trypanosoma cruzi: predicting guide RNAs in the absence of empirical RNA editing.

PubMed

Thomas, Sean; Martinez, L L Isadora Trejo; Westenberger, Scott J; Sturm, Nancy R

2007-05-24

The structurally complex network of minicircles and maxicircles comprising the mitochondrial DNA of kinetoplastids mirrors the complexity of the RNA editing process that is required for faithful expression of encrypted maxicircle genes. Although a few of the guide RNAs that direct this editing process have been discovered on maxicircles, guide RNAs are mostly found on the minicircles. The nuclear and maxicircle genomes have been sequenced and assembled for Trypanosoma cruzi, the causative agent of Chagas disease, however the complement of 1.4-kb minicircles, carrying four guide RNA genes per molecule in this parasite, has been less thoroughly characterised. Fifty-four CL Brener and 53 Esmeraldo strain minicircle sequence reads were extracted from T. cruzi whole genome shotgun sequencing data. With these sequences and all published T. cruzi minicircle sequences, 108 unique guide RNAs from all known T. cruzi minicircle sequences and two guide RNAs from the CL Brener maxicircle were predicted using a local alignment algorithm and mapped onto predicted or experimentally determined sequences of edited maxicircle open reading frames. For half of the sequences no statistically significant guide RNA could be assigned. Likely positions of these unidentified gRNAs in T. cruzi minicircle sequences are estimated using a simple Hidden Markov Model. With the local alignment predictions as a standard, the HMM had an ~85% chance of correctly identifying at least 20 nucleotides of guide RNA from a given minicircle sequence. Inter-minicircle recombination was documented. Variable regions contain species-specific areas of distinct nucleotide preference. Two maxicircle guide RNA genes were found. The identification of new minicircle sequences and the further characterization of all published minicircles are presented, including the first observation of recombination between minicircles. Extrapolation suggests a level of 4% recombinants in the population, supporting a relatively high recombination rate that may serve to minimize the persistence of gRNA pseudogenes. Characteristic nucleotide preferences observed within variable regions provide potential clues regarding the transcription and maturation of T. cruzi guide RNAs. Based on these preferences, a method of predicting T. cruzi guide RNAs using only primary minicircle sequence data was created.

A Guide for Parents and Families about What Your 2nd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 2do Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

ERIC Educational Resources Information Center

South Carolina State Dept. of Education, Columbia.

This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

A Novel Mitochondrial DNA Deletion in Patient with Pearson Syndrome.

PubMed

Khasawneh, Rame; Alsokhni, Hala; Alzghoul, Bayan; Momani, Asim; Abualsheikh, Nazih; Kamal, Nazmi; Qatawneh, Mousa

2018-04-01

Arteriovenous Pearson syndrome is a very rare multisystemic mitochondrial disease characterized by sideroblastic anemia and exocrine pancreatic insufficiency. It is usually fatal in infancy. We reported a four-month-old infant presented with fever and pancytopenia. Bone marrow examination showed hypoplastic changes and sideroblastic features. Molecular Study showed a novel hetroplasmic mitochondrial deletions (m. 10760 -m. 15889+) in multiple genes (ND4,ND5,ND6, CYTB). In our patient the pathogenic mutation was 5.1 kb heteroplasmic deletions in multiple genes that are important and crucial for intact oxidative phosphorylation pathway and ATP production in the mitochondrial DNA. This mutation was not reported in literature including the mitomap.org website (which was last edited on Nov 30, 2017 and accessed on Jan 13, 2018).

Beam quality improvement by population-dynamic-coupled combined guiding effect in end-pumped Nd:YVO4 laser oscillator

NASA Astrophysics Data System (ADS)

Shen, Yijie; Gong, Mali; Fu, Xing

2018-05-01

Beam quality improvement with pump power increasing in an end-pumped laser oscillator is experimentally realized for the first time, to the best of our knowledge. The phenomenon is caused by the population-dynamic-coupled combined guiding effect, a comprehensive theoretical model of which has been well established, in agreement with the experimental results. Based on an 888 nm in-band dual-end-pumped oscillator using four tandem Nd:YVO4 crystals, the output beam quality of M^2= 1.1/1.1 at the pump power of 25 W is degraded to M^2 = 2.5/1.8 at 75 W pumping and then improved to M^2= 1.8/1.3 at 150 W pumping. The near-TEM_{00} mode is obtained with the highest continuous-wave output power of 72.1 W and the optical-to-optical efficiency of 48.1%. This work demonstrates great potential to further scale the output power of end-pumped laser oscillator while keeping good beam quality.

Mapping contacts between gRNA and mRNA in trypanosome RNA editing.

PubMed

Leung, S S; Koslowsky, D J

1999-02-01

All guide RNAs (gRNAs) identified to date have defined 5' anchor sequences, guiding sequences and a non-encoded 3' uridylate tail. The 5' anchor is required for in vitro editing and is thought to be responsible for selection and binding to the pre-edited mRNA. Little is known, however, about how the gRNAs are used to direct RNA editing. Utilizing the photo-reactive crosslinking agent, azidophenacyl (APA), attached to the 5'- or 3'-terminus of the gRNA, we have begun to map the structural relationships between the different defined regions of the gRNA with the pre-edited mRNA. Analyses of crosslinked conjugates produced with a 5'-terminal APA group confirm that the anchor of the gRNA is correctly positioning the interacting molecules. 3' Crosslinks (X-linker placed at the 3'-end of a U10tail) have also been mapped for three different gRNA/mRNA pairs. In all cases, analyses indicate that the U-tail can interact with a range of nucleotides located upstream of the first edited site. It appears that the U-tail prefers purine-rich sites, close to the first few editing sites. These results suggest that the U-tail may act in concert with the anchor to melt out secondary structure in the mRNA in the immediate editing domain, possibly increasing the accessibility of the editing complex to the proper editing sites.

Chromatin accessibility and guide sequence secondary structure affect CRISPR-Cas9 gene editing efficiency.

PubMed

Jensen, Kristopher Torp; Fløe, Lasse; Petersen, Trine Skov; Huang, Jinrong; Xu, Fengping; Bolund, Lars; Luo, Yonglun; Lin, Lin

2017-07-01

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) systems have emerged as the method of choice for genome editing, but large variations in on-target efficiencies continue to limit their applicability. Here, we investigate the effect of chromatin accessibility on Cas9-mediated gene editing efficiency for 20 gRNAs targeting 10 genomic loci in HEK293T cells using both SpCas9 and the eSpCas9(1.1) variant. Our study indicates that gene editing is more efficient in euchromatin than in heterochromatin, and we validate this finding in HeLa cells and in human fibroblasts. Furthermore, we investigate the gRNA sequence determinants of CRISPR-Cas9 activity using a surrogate reporter system and find that the efficiency of Cas9-mediated gene editing is dependent on guide sequence secondary structure formation. This knowledge can aid in the further improvement of tools for gRNA design. © 2017 Federation of European Biochemical Societies.