A residency clinic chronic condition management quality improvement project.

PubMed

Halverson, Larry W; Sontheimer, Dan; Duvall, Sharon

2007-02-01

Quality improvement in chronic disease management is a major agenda for improving health and reducing health care costs. A six-component chronic disease management model can help guide this effort. Several characteristics of the "new model" of family medicine described by the Future of Family Medicine (FFM) Project Leadership Committee are promulgated to foster practice changes that improve quality. Our objective was to implement and assess a quality improvement project guided by the components of a chronic disease management model and FFM new model characteristics. Diabetes was selected as a model chronic disease focus. Multiple practice changes were implemented. A mature electronic medical record facilitated data collection and measurement of quality improvement progress. Data from the diabetes registry demonstrates that our efforts have been effective. Significant improvement occurred in five out of six quality indicators. Multidisciplinary teamwork in a model residency practice guided by chronic disease management principles and the FFM new model characteristics can produce significant management improvements in one important chronic disease.

National Positioning, Navigation, and Timing Architecture Study

NASA Astrophysics Data System (ADS)

van Dyke, K.; Vicario, J.; Hothem, L.

2007-12-01

The purpose of the National Positioning, Navigation and Timing (PNT) Architecture effort is to help guide future PNT system-of-systems investment and implementation decisions. The Assistant Secretary of Defense for Networks and Information Integration and the Under Secretary of Transportation for Policy sponsored a National PNT Architecture study to provide more effective and efficient PNT capabilities focused on the 2025 timeframe and an evolutionary path for government provided systems and services. U.S. Space-Based PNT Policy states that the U.S. must continue to improve and maintain GPS, augmentations to GPS, and back-up capabilities to meet growing national, homeland, and economic security needs. PNT touches almost every aspect of people´s lives today. PNT is essential for Defense and Civilian applications ranging from the Department of Defense´s Joint network centric and precision operations to the transportation and telecommunications sectors, improving efficiency, increasing safety, and being more productive. Absence of an approved PNT architecture results in uncoordinated research efforts, lack of clear developmental paths, potentially wasteful procurements and inefficient deployment of PNT resources. The national PNT architecture effort evaluated alternative future mixes of global (space and non space-based) and regional PNT solutions, PNT augmentations, and autonomous PNT capabilities to address priorities identified in the DoD PNT Joint Capabilities Document (JCD) and civil equivalents. The path to achieving the Should-Be architecture is described by the National PNT Architecture's Guiding Principles, representing an overarching Vision of the US' role in PNT, an architectural Strategy to fulfill that Vision, and four Vectors which support the Strategy. The National PNT Architecture effort has developed nineteen recommendations. Five foundational recommendations are tied directly to the Strategy while the remaining fourteen individually support one of the Vectors, as will be described in this presentation. The results of this effort will support future decisions of bodies such as the DoD PNT and Civil Pos/Nav Executive Committees, as well as the National Space-Based PNT Executive Committee (EXCOM).

Solar Eclipse Education and Outreach Activities at APSU

NASA Astrophysics Data System (ADS)

Smith, J. Allyn; Buckner, Spencer L.; Adams, Mitzi; Meisch, Karen; Sudbrink, Don; Wright, Amy; Adams, Angela; Fagan, Ben

2018-01-01

The path of totality for the 21 August 2017 total solar eclipse passed directly over the APSU campus in north-central Tennessee. We discuss our public outreach and education efforts, both on campus and in the community, and present results and lessons learned from this event. We reached nearly 20,000 people via our efforts and hosted nearly 3000 viewers on campus on eclipse day. We also present our science activities and early results from those. On the whole, this event could be viewed as a large success for the university and the region, and the experiences will guide us in our efforts as we plan future eclipse activities.

Quantifying density-independent mortality of temperate tree species

Treesearch

Heather E Lintz; Andrew N. Gray; Andrew Yost; Richard Sniezko; Chris Woodall; Matt Reilly; Karen Hutten; Mark Elliott

2016-01-01

Forest resilience to climate change is a topic of national concern as our standing assets and future forestsare important to our livelihood. Many tree species are predicted to decline or disappear while othersmay be able to adapt or migrate. Efforts to quantify and disseminate the current condition of forests areurgently needed to guide management and policy. Here, we...

Finding Our Way Home: The Great Lakes Woodland People.

ERIC Educational Resources Information Center

Bennett, Pamela J., Ed.

2001-01-01

This issue of this magazine is part of an effort to heighten the knowledge of students and teachers about Indiana's American Indian connections past, present, and future. The issue is a guide to accompany the 2001 original play, "People of the Turtle." It can stand alone as a starting place for students interested in learning about, and…

Cyber Intelligence Research Consortium (Poster)

DTIC Science & Technology

2014-10-24

OCT 2014 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Cyber Intelligence Research Consortium Poster 5a. CONTRACT NUMBER 5b...nontechnical audiences Environmental Context Provides scope for the analytical effort • Highlights the importance of context - technical and nontechnical... Environmental Context Reporting & Feedback Macroanalysis Microanalysis Data Gathering Steering Committee: Guide Consortium activities and plan for future

Advisory Groups to Encourage Collaboration: A Case Study

ERIC Educational Resources Information Center

Stephens, Lisa A.; Glynn, Graham; Lavallee, David; Moreau, Joseph; Orzech, Mary Jo; Pence, Harry E.

2011-01-01

This article is a case study of how the provost and senior executive leadership of one large university system capitalized on a long-standing advisory group as a tool to support communication and collaboration across a broad constituency. These advisory efforts help guide both future directions and investment. It is the story of how this group has…

Proceedings of the Redwood Region Forest Science Symposium: What does the future hold?

Treesearch

Richard B. Standiford; Gregory A. Giusti; Yana Valachovic; William J. Zielinski; Michael J. Furniss

2007-01-01

Policies and strategies that guide use and management of lands in the coastal ecoregion are dependent on objective scientific information. In recent years attention to this region has increased. Correspondingly, there has been much new information collected. Efforts such as the Caspar Creek Watershed Conference and the Scientific Basis for the Prediction of Cumulative...

Mapping the current and potential distribution of red spruce in Virginia: implications for the restoration of degraded high elevation habitat

Treesearch

Heather Griscom; Helmut Kraenzle; Zachary. Bortolot

2010-01-01

The objective of our project is to create a habitat suitability model to predict potential and future red spruce forest distributions. This model will be used to better understand the influence of climate change on red spruce distribution and to help guide forest restoration efforts.

Intelligence Level Performance Standards Research for Autonomous Vehicles

PubMed Central

Bostelman, Roger B.; Hong, Tsai H.; Messina, Elena

2017-01-01

United States and European safety standards have evolved to protect workers near Automatic Guided Vehicles (AGV’s). However, performance standards for AGV’s and mobile robots have only recently begun development. Lessons can be learned from research and standards efforts for mobile robots applied to emergency response and military applications. Research challenges, tests and evaluations, and programs to develop higher intelligence levels for vehicles can also used to guide industrial AGV developments towards more adaptable and intelligent systems. These other efforts also provide useful standards development criteria for AGV performance test methods. Current standards areas being considered for AGVs are for docking, navigation, obstacle avoidance, and the ground truth systems that measure performance. This paper provides a look to the future with standards developments in both the performance of vehicles and the dynamic perception systems that measure intelligent vehicle performance. PMID:28649189

Intelligence Level Performance Standards Research for Autonomous Vehicles.

PubMed

Bostelman, Roger B; Hong, Tsai H; Messina, Elena

2015-01-01

United States and European safety standards have evolved to protect workers near Automatic Guided Vehicles (AGV's). However, performance standards for AGV's and mobile robots have only recently begun development. Lessons can be learned from research and standards efforts for mobile robots applied to emergency response and military applications. Research challenges, tests and evaluations, and programs to develop higher intelligence levels for vehicles can also used to guide industrial AGV developments towards more adaptable and intelligent systems. These other efforts also provide useful standards development criteria for AGV performance test methods. Current standards areas being considered for AGVs are for docking, navigation, obstacle avoidance, and the ground truth systems that measure performance. This paper provides a look to the future with standards developments in both the performance of vehicles and the dynamic perception systems that measure intelligent vehicle performance.

Emerging issues in public health genomics

PubMed Central

Roberts, J. Scott

2014-01-01

This review highlights emerging areas of interest in public health genomics. First, recent advances in newborn screening (NBS) are described, with a focus on practice and policy implications of current and future efforts to expand NBS programs (e.g., via next-generation sequencing). Next, research findings from the rapidly progressing field of epigenetics and epigenomics are detailed, highlighting ways in which our emerging understanding in these areas could guide future intervention and research efforts in public health. We close by considering various ethical, legal and social issues posed by recent developments in public health genomics; these include policies to regulate access to personal genomic information; the need to enhance genetic literacy in both health professionals and the public; and challenges in ensuring that the benefits (and burdens) from genomic discoveries and applications are equitably distributed. Needs for future genomics research that integrates across basic and social sciences are also noted. PMID:25184533

Computational Modeling for Enhancing Soft Tissue Image Guided Surgery: An Application in Neurosurgery.

PubMed

Miga, Michael I

2016-01-01

With the recent advances in computing, the opportunities to translate computational models to more integrated roles in patient treatment are expanding at an exciting rate. One area of considerable development has been directed towards correcting soft tissue deformation within image guided neurosurgery applications. This review captures the efforts that have been undertaken towards enhancing neuronavigation by the integration of soft tissue biomechanical models, imaging and sensing technologies, and algorithmic developments. In addition, the review speaks to the evolving role of modeling frameworks within surgery and concludes with some future directions beyond neurosurgical applications.

Sex Roles, Past, Present and Future; A Guide to Simulations, Games and Activities. 2nd Edition.

ERIC Educational Resources Information Center

Population Inst., Washington, DC.

This brief listing describes games, activities, awareness exercises and projects which explore the realities and myths about the nature, history and potential of men and women. Among the activities are projects designed for children and adults, for individuals, groups, clubs, couples and classes. They can be used in self-education efforts, in…

At Issue: Marriage. Exploring the Debate over Marriage Rights for Same-Sex Couples: A Curriculum Guide for High School Educators.

ERIC Educational Resources Information Center

Gay, Lesbian, and Straight Education Network, New York, NY.

The Gay, Lesbian, and Straight Education Network (GLSEN) aims to unite with educators in cultivating an informed citizenry and future generations of children who respect and accept all people, regardless of their sexual orientation or gender identity. By supporting educators in their efforts to build schools where information and expression flow…

Perspectives On Dilution Jet Mixing

NASA Technical Reports Server (NTRS)

Holdeman, J. D.; Srinivasan, R.

1990-01-01

NASA recently completed program of measurements and modeling of mixing of transverse jets with ducted crossflow, motivated by need to design or tailor temperature pattern at combustor exit in gas turbine engines. Objectives of program to identify dominant physical mechanisms governing mixing, extend empirical models to provide near-term predictive capability, and compare numerical code calculations with data to guide future analysis improvement efforts.

Template protocol for clinical trials investigating vaccines—Focus on safety elements☆

PubMed Central

Bonhoeffer, Jan; Imoukhuede, Egeruan B.; Aldrovandi, Grace; Bachtiar, Novilia S.; Chan, Eng-Soon; Chang, Soju; Chen, Robert T.; Fernandopulle, Rohini; Goldenthal, Karen L.; Heffelfinger, James D.; Hossain, Shah; Jevaji, Indira; Khamesipour, Ali; Kochhar, Sonali; Makhene, Mamodikoe; Malkin, Elissa; Nalin, David; Prevots, Rebecca; Ramasamy, Ranjan; Sellers, Sarah; Vekemans, Johan; Walker, Kenneth B.; Wilson, Pam; Wong, Virginia; Zaman, Khalequz; Heininger, Ulrich

2015-01-01

This document is intended as a guide to the protocol development for trials of prophylactic vaccines. The template may serve phases I–IV clinical trials protocol development to include safety relevant information as required by the regulatory authorities and as deemed useful by the investigators. This document may also be helpful for future site strengthening efforts. PMID:23499603

A new remote hazard and risk assessment framework for glacial lakes in the Nepal Himalaya

NASA Astrophysics Data System (ADS)

Rounce, David R.; McKinney, Daene C.; Lala, Jonathan M.; Byers, Alton C.; Watson, C. Scott

2016-08-01

Glacial lake outburst floods (GLOFs) pose a significant threat to downstream communities and infrastructure due to their potential to rapidly unleash stored lake water. The most common triggers of these GLOFs are mass movement entering the lake and/or the self-destruction of the terminal moraine due to hydrostatic pressures or a buried ice core. This study initially uses previous qualitative and quantitative assessments to understand the hazards associated with eight glacial lakes in the Nepal Himalaya that are widely considered to be highly dangerous. The previous assessments yield conflicting classifications with respect to each glacial lake, which spurred the development of a new holistic, reproducible, and objective approach based solely on remotely sensed data. This remote hazard assessment analyzes mass movement entering the lake, the stability of the moraine, and lake growth in conjunction with a geometric GLOF to determine the downstream impacts such that the present and future risk associated with each glacial lake may be quantified. The new approach is developed within a hazard, risk, and management action framework with the aim that this remote assessment may guide future field campaigns, modeling efforts, and ultimately risk-mitigation strategies. The remote assessment was found to provide valuable information regarding the hazards faced by each glacial lake and results were discussed within the context of the current state of knowledge to help guide future efforts.

Improving Environmental Health Literacy and Justice through Environmental Exposure Results Communication

PubMed Central

Ramirez-Andreotta, Monica D.; Brody, Julia Green; Lothrop, Nathan; Loh, Miranda; Beamer, Paloma I.; Brown, Phil

2016-01-01

Understanding the short- and long-term impacts of a biomonitoring and exposure project and reporting personal results back to study participants is critical for guiding future efforts, especially in the context of environmental justice. The purpose of this study was to evaluate learning outcomes from environmental communication efforts and whether environmental health literacy goals were met in an environmental justice community. We conducted 14 interviews with parents who had participated in the University of Arizona’s Metals Exposure Study in Homes and analyzed their responses using NVivo, a qualitative data management and analysis program. Key findings were that participants used the data to cope with their challenging circumstances, the majority of participants described changing their families’ household behaviors, and participants reported specific interventions to reduce family exposures. The strength of this study is that it provides insight into what people learn and gain from such results communication efforts, what participants want to know, and what type of additional information participants need to advance their environmental health literacy. This information can help improve future report back efforts and advance environmental health and justice. PMID:27399755

Commentary: evidence to guide gun violence prevention in America.

PubMed

Webster, Daniel W

2015-03-18

Gun violence is a major threat to the public's health and safety in the United States. The articles in this volume's symposium on gun violence reveal the scope of the problem and new trends in mortality rates from gunfire. Leading scholars synthesize research evidence that demonstrates the ability of numerous policies and programs-each consistent with lessons learned from successful efforts to combat public health problems-to prevent gun violence. Each approach presents challenges to successful implementation. Future research should inform efforts to assess which approaches are most effective and how to implement evidence-based interventions most effectively.

How the Army Runs: A Senior Leader Reference Handbook, 2015-2016

DTIC Science & Technology

2015-08-28

sector , creates a recruiting multiplier, improves employment prospects for transitioning personnel, reduces unemployment compensation costs to the Army...and the private sector . (3) Consider three general time frames of near-term (associate with the future-years defense program), mid-term (10-15...TRADOC Pamphlet 525-66 also guides Independent Research & Development (IR&D) efforts. By providing the private sector an unclassified, descriptive

The Annie E. Casey Foundation 2006 Kids Count Pocket Guide. State Profiles of Child Well-Being Series

ERIC Educational Resources Information Center

Annie E. Casey Foundation, 2006

2006-01-01

Kids Count, a project of the Annie E. Casey Foundation, is a national and state by- state effort to track the status of children in the United States. By providing policymakers and citizens with benchmarks of child well-being, Kids Count seeks to enrich local, state, and national discussions concerning ways to secure better futures for all…

Template protocol for clinical trials investigating vaccines--focus on safety elements.

PubMed

Bonhoeffer, Jan; Imoukhuede, Egeruan B; Aldrovandi, Grace; Bachtiar, Novilia S; Chan, Eng-Soon; Chang, Soju; Chen, Robert T; Fernandopulle, Rohini; Goldenthal, Karen L; Heffelfinger, James D; Hossain, Shah; Jevaji, Indira; Khamesipour, Ali; Kochhar, Sonali; Makhene, Mamodikoe; Malkin, Elissa; Nalin, David; Prevots, Rebecca; Ramasamy, Ranjan; Sellers, Sarah; Vekemans, Johan; Walker, Kenneth B; Wilson, Pam; Wong, Virginia; Zaman, Khalequz; Heininger, Ulrich

2013-11-12

This document is intended as a guide to the protocol development for trials of prophylactic vaccines. The template may serve phases I-IV clinical trials protocol development to include safety relevant information as required by the regulatory authorities and as deemed useful by the investigators. This document may also be helpful for future site strengthening efforts. Copyright © 2013 Elsevier Ltd. All rights reserved.

Microgrid Modeling and Simulation Study

DTIC Science & Technology

2016-09-01

will be used to guide DOD M&S strategy and planning, as well as develop a comprehensive microgrid M&S capability and prioritize future efforts...contingencies and sequencing (Short term investment) Peer-to-peer Rapid send- listen techniques M&S is needed to determine an approach for handling...tactical microgrid network with interconnected grids. ○ Rapid Send- Listen Techniques is a specific enabler necessary for communications in a

Principles of effective USA federal fire management plans

USGS Publications Warehouse

Meyer, Marc D.; Roberts, Susan L.; Wills, Robin; Brooks, Matthew L.; Winford, Eric M.

2015-01-01

Federal fire management plans are essential implementation guides for the management of wildland fire on federal lands. Recent changes in federal fire policy implementation guidance and fire science information suggest the need for substantial changes in federal fire management plans of the United States. Federal land management agencies are also undergoing land management planning efforts that will initiate revision of fire management plans across the country. Using the southern Sierra Nevada as a case study, we briefly describe the underlying framework of fire management plans, assess their consistency with guiding principles based on current science information and federal policy guidance, and provide recommendations for the development of future fire management plans. Based on our review, we recommend that future fire management plans be: (1) consistent and compatible, (2) collaborative, (3) clear and comprehensive, (4) spatially and temporally scalable, (5) informed by the best available science, and (6) flexible and adaptive. In addition, we identify and describe several strategic guides or “tools” that can enhance these core principles and benefit future fire management plans in the following areas: planning and prioritization, science integration, climate change adaptation, partnerships, monitoring, education and communication, and applied fire management. These principles and tools are essential to successfully realize fire management goals and objectives in a rapidly changing world.

Celebrating 125 years of the U.S. Geological Survey

USGS Publications Warehouse

Gohn, Kathleen K.

2004-01-01

In the 125 years since its creation, the U.S. Geological Survey (USGS) has provided the science information needed to make vital decisions and safeguard society. In this anniversary year, we celebrate the mission that has guided us, the people and traditions that have shaped us, and the science and technology that will lead us into the future. Through a wealth of long-term data and research, we have served the needs of society, the Earth, and its environment. This Circular captures a few of our past achievements, current research efforts, and hopes and challenges for the future.

The Systems Autonomy Demonstration Project - Catalyst for Space Station advanced automation

NASA Technical Reports Server (NTRS)

Healey, Kathleen J.

1988-01-01

The Systems Autonomy Demonstration Project (SADP) was initiated by NASA to address the advanced automation needs for the Space Station program. The application of advanced automation to the Space Station's operations management system (OMS) is discussed. The SADP's future goals and objectives are discussed with respect to OMS functional requirements, design, and desired evolutionary capabilities. Major technical challenges facing the designers, developers, and users of the OMS are identified in order to guide the definition of objectives, plans, and scenarios for future SADP demonstrations, and to focus the efforts on the supporting research.

Applied analytical combustion/emissions research at the NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

1992-01-01

Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

Applied Analytical Combustion/emissions Research at the NASA Lewis Research Center - a Progress Report

NASA Technical Reports Server (NTRS)

Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

1992-01-01

Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

Defense Acquisition Workforce: Actions Needed to Guide Planning Efforts and Improve Workforce Capability

DTIC Science & Technology

2015-12-01

positions. However, 6 of the 13 acquisition career fields, including 3 priority career fields—contracting, business and engineering—did not meet growth...the competency assessment process and challenges. The leaders we interviewed were from the business ; program management; contracting; engineering...Complete Assessments to Improve Future Civilian Strategic Workforce Plans, GAO-12- 1014 (Washington, D.C.: September 27, 2012). 5GAO, High-Risk Series: An

Fundamental constructs in food parenting practices: a content map to guide future research

PubMed Central

Ward, Dianne S.; Fisher, Jennifer O.; Faith, Myles S.; Hughes, Sheryl O.; Kremers, Stef P.J.; Musher-Eizenman, Dara R.; O’Connor, Teresia M.; Patrick, Heather; Power, Thomas G.

2016-01-01

Although research shows that “food parenting practices” can impact children’s diet and eating habits, current understanding of the impact of specific practices has been limited by inconsistencies in terminology and definitions. This article represents a critical appraisal of food parenting practices, including clear terminology and definitions, by a working group of content experts. The result of this effort was the development of a content map for future research that presents 3 overarching, higher-order food parenting constructs – coercive control, structure, and autonomy support – as well as specific practice subconstructs. Coercive control includes restriction, pressure to eat, threats and bribes, and using food to control negative emotions. Structure includes rules and limits, limited/guided choices, monitoring, meal- and snacktime routines, modeling, food availability and accessibility, food preparation, and unstructured practices. Autonomy support includes nutrition education, child involvement, encouragement, praise, reasoning, and negotiation. Literature on each construct is reviewed, and directions for future research are offered. Clear terminology and definitions should facilitate cross-study comparisons and minimize conflicting findings resulting from previous discrepancies in construct operationalization. PMID:26724487

Borophene as a prototype for synthetic 2D materials development.

PubMed

Mannix, Andrew J; Zhang, Zhuhua; Guisinger, Nathan P; Yakobson, Boris I; Hersam, Mark C

2018-06-01

The synthesis of 2D materials with no analogous bulk layered allotropes promises a substantial breadth of physical and chemical properties through the diverse structural options afforded by substrate-dependent epitaxy. However, despite the joint theoretical and experimental efforts to guide materials discovery, successful demonstrations of synthetic 2D materials have been rare. The recent synthesis of 2D boron polymorphs (that is, borophene) provides a notable example of such success. In this Perspective, we discuss recent progress and future opportunities for borophene research. Borophene combines unique mechanical properties with anisotropic metallicity, which complements the canon of conventional 2D materials. The multi-centre characteristics of boron-boron bonding lead to the formation of configurationally varied, vacancy-mediated structural motifs, providing unprecedented diversity in a mono-elemental 2D system with potential for electronic applications, chemical functionalization, materials synthesis and complex heterostructures. With its foundations in computationally guided synthesis, borophene can serve as a prototype for ongoing efforts to discover and exploit synthetic 2D materials.

Borophene as a prototype for synthetic 2D materials development

NASA Astrophysics Data System (ADS)

Mannix, Andrew J.; Zhang, Zhuhua; Guisinger, Nathan P.; Yakobson, Boris I.; Hersam, Mark C.

2018-06-01

The synthesis of 2D materials with no analogous bulk layered allotropes promises a substantial breadth of physical and chemical properties through the diverse structural options afforded by substrate-dependent epitaxy. However, despite the joint theoretical and experimental efforts to guide materials discovery, successful demonstrations of synthetic 2D materials have been rare. The recent synthesis of 2D boron polymorphs (that is, borophene) provides a notable example of such success. In this Perspective, we discuss recent progress and future opportunities for borophene research. Borophene combines unique mechanical properties with anisotropic metallicity, which complements the canon of conventional 2D materials. The multi-centre characteristics of boron-boron bonding lead to the formation of configurationally varied, vacancy-mediated structural motifs, providing unprecedented diversity in a mono-elemental 2D system with potential for electronic applications, chemical functionalization, materials synthesis and complex heterostructures. With its foundations in computationally guided synthesis, borophene can serve as a prototype for ongoing efforts to discover and exploit synthetic 2D materials.

Dissemination and implementation science in program evaluation: A telemental health clinical consultation case example.

PubMed

Arora, Prerna G; Connors, Elizabeth H; Blizzard, Angela; Coble, Kelly; Gloff, Nicole; Pruitt, David

2017-02-01

Increased attention has been placed on evaluating the extent to which clinical programs that support the behavioral health needs of youth have effective processes and result in improved patient outcomes. Several theoretical frameworks from dissemination and implementation (D&I) science have been put forth to guide the evaluation of behavioral health program implemented in the context of real-world settings. Although a strong rationale for the integration of D&I science in program evaluation exists, few examples exist available to guide the evaluator in integrating D&I science in the planning and execution of evaluation activities. This paper seeks to inform program evaluation efforts by outlining two D&I frameworks and describing their integration in program evaluation design. Specifically, this paper seeks to support evaluation efforts by illustrating the use of these frameworks via a case example of a telemental health consultation program in pediatric primary care designed to improve access to behavioral health care for children and adolescents in rural settings. Lessons learned from this effort, as well as recommendations regarding the future evaluation of programs using D&I science to support behavioral health care in community-based settings are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

From Politics to Parity: Using a Health Disparities Index to Guide Legislative Efforts for Health Equity

PubMed Central

Simpson, Sean L.; Hairston, Kristen G.

2011-01-01

Objectives. We created an index quantifying the longitudinal burden of racial health disparities by state and compared this index to variables to guide the construction of, and validate support for, legislative efforts aimed at eliminating health disparities. Methods. We evaluated 5 focus areas of greatest racial disparities in health from 1999 to 2005 and compiled state health disparities index (HDI) scores. We compared these scores with variables representing the purported social determinants of health. Results. Massachusetts (0.35), Oklahoma (0.35), and Washington (0.39) averaged the fewest disparities. Michigan (1.22), Wisconsin (1.32), and Illinois (1.50) averaged the greatest disparities. The statistical reference point for nationwide average racial disparities was 1.00. The longitudinal mixed model procedure yielded statistically significant correlations between HDI scores and Black state population percentage as well as with the racial gap in uninsured percentages. We noted a trend for HDI correlations with median household income ratios. Conclusions. On the basis of the HDI-established trends in the extent and distribution of racial health disparities, and their correlated social determinants of health, policymakers should consider incorporating this tool to advise future efforts in minority health legislation. PMID:21233445

Engineering chemical interactions in microbial communities.

PubMed

Kenny, Douglas J; Balskus, Emily P

2018-03-05

Microbes living within host-associated microbial communities (microbiotas) rely on chemical communication to interact with surrounding organisms. These interactions serve many purposes, from supplying the multicellular host with nutrients to antagonizing invading pathogens, and breakdown of chemical signaling has potentially negative consequences for both the host and microbiota. Efforts to engineer microbes to take part in chemical interactions represent a promising strategy for modulating chemical signaling within these complex communities. In this review, we discuss prominent examples of chemical interactions found within host-associated microbial communities, with an emphasis on the plant-root microbiota and the intestinal microbiota of animals. We then highlight how an understanding of such interactions has guided efforts to engineer microbes to participate in chemical signaling in these habitats. We discuss engineering efforts in the context of chemical interactions that enable host colonization, promote host health, and exclude pathogens. Finally, we describe prominent challenges facing this field and propose new directions for future engineering efforts.

Detecting seasonal and cyclical trends in agricultural runoff water quality-hypothesis tests and block bootstrap power analysis.

PubMed

Uddameri, Venkatesh; Singaraju, Sreeram; Hernandez, E Annette

2018-02-21

Seasonal and cyclic trends in nutrient concentrations at four agricultural drainage ditches were assessed using a dataset generated from a multivariate, multiscale, multiyear water quality monitoring effort in the agriculturally dominant Lower Rio Grande Valley (LRGV) River Watershed in South Texas. An innovative bootstrap sampling-based power analysis procedure was developed to evaluate the ability of Mann-Whitney and Noether tests to discern trends and to guide future monitoring efforts. The Mann-Whitney U test was able to detect significant changes between summer and winter nutrient concentrations at sites with lower depths and unimpeded flows. Pollutant dilution, non-agricultural loadings, and in-channel flow structures (weirs) masked the effects of seasonality. The detection of cyclical trends using the Noether test was highest in the presence of vegetation mainly for total phosphorus and oxidized nitrogen (nitrite + nitrate) compared to dissolved phosphorus and reduced nitrogen (total Kjeldahl nitrogen-TKN). Prospective power analysis indicated that while increased monitoring can lead to higher statistical power, the effect size (i.e., the total number of trend sequences within a time-series) had a greater influence on the Noether test. Both Mann-Whitney and Noether tests provide complementary information on seasonal and cyclic behavior of pollutant concentrations and are affected by different processes. The results from these statistical tests when evaluated in the context of flow, vegetation, and in-channel hydraulic alterations can help guide future data collection and monitoring efforts. The study highlights the need for long-term monitoring of agricultural drainage ditches to properly discern seasonal and cyclical trends.

Brain natriuretic peptide-guided therapy in the inpatient management of decompensated heart failure.

PubMed

Saremi, Adonis; Gopal, Dipika; Maisel, Alan S

2012-02-01

Heart failure is extremely prevalent and is associated with significant mortality, morbidity and cost. Studies have already established mortality benefit with the use of neurohormonal blockade therapy in systolic failure. Unfortunately, physical signs and symptoms of heart failure lack diagnostic sensitivity and specificity, and medication doses proven to improve mortality in clinical trials are often not achieved. Brain natriuretic peptide (BNP) has proven to be of clinical use in the diagnosis and prognosis of heart failure, and recent efforts have been taken to further elucidate its role in guiding heart failure management. Multiple studies have been conducted on outpatient guided management, and although still controversial, there is a trend towards improved outcomes. Inpatient studies are lacking, but preliminary data suggest various BNP cut-off values, as well as percentage changes in BNP, that could be useful in predicting outcomes and improving mortality. In the future, heart failure management will probably involve an algorithm using clinical assessment and a multibiomarker-guided approach.

RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?

PubMed

Gasiunas, Giedrius; Siksnys, Virginijus

2013-11-01

Tailor-made nucleases for precise genome modification, such as zinc finger or TALE nucleases, currently represent the state-of-the-art for genome editing. These nucleases combine a programmable protein module which guides the enzyme to the target site with a nuclease domain which cuts DNA at the addressed site. Reprogramming of these nucleases to cut genomes at specific locations requires major protein engineering efforts. RNA-guided DNA endonuclease Cas9 of the type II (clustered regularly interspaced short palindromic repeat) CRISPR-Cas system uses CRISPR RNA (crRNA) as a guide to locate the DNA target and the Cas9 protein to cut DNA. Easy programmability of the Cas9 endonuclease using customizable RNAs brings unprecedented flexibility and versatility for targeted genome modification. We highlight the potential of the Cas9 RNA-guided DNA endonuclease as a novel tool for genome surgery, and discuss possible constraints and future prospects. Copyright © 2013 Elsevier Ltd. All rights reserved.

Intentionally Linking Gateway-Course Transformation Efforts with Guided Pathways

ERIC Educational Resources Information Center

Rife, Martine Courant; Conner, Christine

2017-01-01

Offered as a case study, this chapter shows how Lansing Community College intentionally combined efforts to redesign eight high-risk courses with efforts to create clearer guided curricular pathways for the college's students.

A comparison of petrophysical data inputs for establishing time-depth relationships: a guide for future drilling expeditions

NASA Astrophysics Data System (ADS)

Boaga, J.; Sauermilch, I.; Mateo, Z. R. P.

2017-12-01

Time-depth relationships (TDR) are crucial in correlating drillhole and core information to seismic reflection profiles, for accurate resource estimation, scientific interpretation and to guide drilling operations. Conventional seismic time-depth domain conversion utilizes downhole sonic logs (DSI), calibrated using available checkshot data, which are local travel times from the surface to a particular depth. Scientific drilling programs (ODP and IODP) also measure P-wave velocity (PWL or C) on recovered core samples. Only three percent of all ODP and IODP sites record all three velocity measurements, however this information can be instructive as sometimes these data input show dissimilar TDR. These representative sites provide us with an opportunity to perform a comparative analysis highlighting the differences and similarities of TDRs derived from checkshot, downhole, and laboratory measurements. We then discuss the impact of lithology, stratigraphy, water column and other petrophysical properties in the predictive accuracy of TDR calculations, in an effort to provide guidance for future drilling and coring expeditions.

NASA Laser Remote Sensing Technology Needs for Earth Science in the Next Decade and Beyond

NASA Technical Reports Server (NTRS)

Trait, David M.; Neff, Jon M.; Valinia, Azita

2007-01-01

In late 2005 the NASA Earth Science Technology Office convened a working group to review decadal-term technology needs for Earth science active optical remote sensing objectives. The outcome from this effort is intended to guide future NASA investments in laser remote sensing technologies. This paper summarizes the working group findings and places them in context with the conclusions of the National Research Council assessment of Earth science needs, completed in 2007.

What Works? Common Practices in High Functioning Afterschool Programs across the Nation in Math, Reading, Science, Arts, Technology, and Homework--A Study by the National Partnership. The Afterschool Program Assessment Guide. CRESST Report 768

ERIC Educational Resources Information Center

Huang, Denise; Cho, Jamie; Mostafavi, Sima; Nam, Hannah H.; Oh, Christine; Harven, Aletha; Leon, Seth

2010-01-01

In an effort to identify and incorporate exemplary practices into existing and future afterschool programs, the U.S. Department of Education commissioned a large-scale evaluation of the 21st Century Community Learning Center (CCLC) program. The purpose of this evaluation project was to develop resources and professional development that addresses…

AMTD: Update of Engineering Specifications Derived from Science Requirements for Future UVOIR Space Telescopes

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2014-01-01

AMTD is using a Science Driven Systems Engineering approach to develop Engineering Specifications based on Science Measurement Requirements and Implementation Constraints. Science requirements meet the needs of both Exoplanet and General Astrophysics science. Engineering Specifications are guiding our effort to mature to TRL-6 the critical technologies needed to produce 4-m or larger flight-qualified UVOIR mirrors by 2018 so that a viable mission can be considered by the 2020 Decadal Review.

The Army’s Future Combat Systems Program and Alternatives

DTIC Science & Technology

2006-08-01

crisis anywhere in the world.sea. Their additional equipment primarily comprises hundreds of armored vehicles and heavy and medium- weight trucks (see...Combat Vehicle Reference Guide,” available at www.inetres.com/gp/ military/cv/index.html; and Christopher Foss, ed., Jane’s Armour and Artillery, 1979-1980...stages of a crisis . After that, the level of effort is reduced to one that can be maintained indefinitely. 6 ft.timated time such ships would require

Case study of evaluations that go beyond clinical outcomes to assess quality improvement diabetes programmes using the Diabetes Evaluation Framework for Innovative National Evaluations (DEFINE).

PubMed

Paquette-Warren, Jann; Harris, Stewart B; Naqshbandi Hayward, Mariam; Tompkins, Jordan W

2016-10-01

Investments in efforts to reduce the burden of diabetes on patients and health care are critical; however, more evaluation is needed to provide evidence that informs and supports future policies and programmes. The newly developed Diabetes Evaluation Framework for Innovative National Evaluations (DEFINE) incorporates the theoretical concepts needed to facilitate the capture of critical information to guide investments, policy and programmatic decision making. The aim of the study is to assess the applicability and value of DEFINE in comprehensive real-world evaluation. Using a critical and positivist approach, this intrinsic and collective case study retrospectively examines two naturalistic evaluations to demonstrate how DEFINE could be used when conducting real-world comprehensive evaluations in health care settings. The variability between the cases and the evaluation designs are described and aligned to the DEFINE goals, steps and sub-steps. The majority of the theoretical steps of DEFINE were exemplified in both cases, although limited for knowledge translation efforts. Application of DEFINE to evaluate diverse programmes that target various chronic diseases is needed to further test the inclusivity and built-in flexibility of DEFINE and its role in encouraging more comprehensive knowledge translation. This case study shows how DEFINE could be used to structure or guide comprehensive evaluations of programmes and initiatives implemented in health care settings and support scale-up of successful innovations. Future use of the framework will continue to strengthen its value in guiding programme evaluation and informing health policy to reduce the burden of diabetes and other chronic diseases. © 2016 The Authors. Journal of Evaluation in Clinical Practice published by John Wiley & Sons, Ltd.

Case study of evaluations that go beyond clinical outcomes to assess quality improvement diabetes programmes using the Diabetes Evaluation Framework for Innovative National Evaluations (DEFINE)

PubMed Central

Harris, Stewart B.; Naqshbandi Hayward, Mariam; Tompkins, Jordan W.

2016-01-01

Abstract Rationale, aims and objectives Investments in efforts to reduce the burden of diabetes on patients and health care are critical; however, more evaluation is needed to provide evidence that informs and supports future policies and programmes. The newly developed Diabetes Evaluation Framework for Innovative National Evaluations (DEFINE) incorporates the theoretical concepts needed to facilitate the capture of critical information to guide investments, policy and programmatic decision making. The aim of the study is to assess the applicability and value of DEFINE in comprehensive real‐world evaluation. Method Using a critical and positivist approach, this intrinsic and collective case study retrospectively examines two naturalistic evaluations to demonstrate how DEFINE could be used when conducting real‐world comprehensive evaluations in health care settings. Results The variability between the cases and the evaluation designs are described and aligned to the DEFINE goals, steps and sub‐steps. The majority of the theoretical steps of DEFINE were exemplified in both cases, although limited for knowledge translation efforts. Application of DEFINE to evaluate diverse programmes that target various chronic diseases is needed to further test the inclusivity and built‐in flexibility of DEFINE and its role in encouraging more comprehensive knowledge translation. Conclusions This case study shows how DEFINE could be used to structure or guide comprehensive evaluations of programmes and initiatives implemented in health care settings and support scale‐up of successful innovations. Future use of the framework will continue to strengthen its value in guiding programme evaluation and informing health policy to reduce the burden of diabetes and other chronic diseases. PMID:26804339

Image-guided tissue engineering

PubMed Central

Ballyns, Jeffrey J; Bonassar, Lawrence J

2009-01-01

Replication of anatomic shape is a significant challenge in developing implants for regenerative medicine. This has lead to significant interest in using medical imaging techniques such as magnetic resonance imaging and computed tomography to design tissue engineered constructs. Implementation of medical imaging and computer aided design in combination with technologies for rapid prototyping of living implants enables the generation of highly reproducible constructs with spatial resolution up to 25 μm. In this paper, we review the medical imaging modalities available and a paradigm for choosing a particular imaging technique. We also present fabrication techniques and methodologies for producing cellular engineered constructs. Finally, we comment on future challenges involved with image guided tissue engineering and efforts to generate engineered constructs ready for implantation. PMID:19583811

Nuclear Engine System Simulation (NESS). Volume 1: Program user's guide

NASA Astrophysics Data System (ADS)

Pelaccio, Dennis G.; Scheil, Christine M.; Petrosky, Lyman J.

1993-03-01

A Nuclear Thermal Propulsion (NTP) engine system design analysis tool is required to support current and future Space Exploration Initiative (SEI) propulsion and vehicle design studies. Currently available NTP engine design models are those developed during the NERVA program in the 1960's and early 1970's and are highly unique to that design or are modifications of current liquid propulsion system design models. To date, NTP engine-based liquid design models lack integrated design of key NTP engine design features in the areas of reactor, shielding, multi-propellant capability, and multi-redundant pump feed fuel systems. Additionally, since the SEI effort is in the initial development stage, a robust, verified NTP analysis design tool could be of great use to the community. This effort developed an NTP engine system design analysis program (tool), known as the Nuclear Engine System Simulation (NESS) program, to support ongoing and future engine system and stage design study efforts. In this effort, Science Applications International Corporation's (SAIC) NTP version of the Expanded Liquid Engine Simulation (ELES) program was modified extensively to include Westinghouse Electric Corporation's near-term solid-core reactor design model. The ELES program has extensive capability to conduct preliminary system design analysis of liquid rocket systems and vehicles. The program is modular in nature and is versatile in terms of modeling state-of-the-art component and system options as discussed. The Westinghouse reactor design model, which was integrated in the NESS program, is based on the near-term solid-core ENABLER NTP reactor design concept. This program is now capable of accurately modeling (characterizing) a complete near-term solid-core NTP engine system in great detail, for a number of design options, in an efficient manner. The following discussion summarizes the overall analysis methodology, key assumptions, and capabilities associated with the NESS presents an example problem, and compares the results to related NTP engine system designs. Initial installation instructions and program disks are in Volume 2 of the NESS Program User's Guide.

Nuclear Engine System Simulation (NESS). Volume 1: Program user's guide

NASA Technical Reports Server (NTRS)

Pelaccio, Dennis G.; Scheil, Christine M.; Petrosky, Lyman J.

1993-01-01

A Nuclear Thermal Propulsion (NTP) engine system design analysis tool is required to support current and future Space Exploration Initiative (SEI) propulsion and vehicle design studies. Currently available NTP engine design models are those developed during the NERVA program in the 1960's and early 1970's and are highly unique to that design or are modifications of current liquid propulsion system design models. To date, NTP engine-based liquid design models lack integrated design of key NTP engine design features in the areas of reactor, shielding, multi-propellant capability, and multi-redundant pump feed fuel systems. Additionally, since the SEI effort is in the initial development stage, a robust, verified NTP analysis design tool could be of great use to the community. This effort developed an NTP engine system design analysis program (tool), known as the Nuclear Engine System Simulation (NESS) program, to support ongoing and future engine system and stage design study efforts. In this effort, Science Applications International Corporation's (SAIC) NTP version of the Expanded Liquid Engine Simulation (ELES) program was modified extensively to include Westinghouse Electric Corporation's near-term solid-core reactor design model. The ELES program has extensive capability to conduct preliminary system design analysis of liquid rocket systems and vehicles. The program is modular in nature and is versatile in terms of modeling state-of-the-art component and system options as discussed. The Westinghouse reactor design model, which was integrated in the NESS program, is based on the near-term solid-core ENABLER NTP reactor design concept. This program is now capable of accurately modeling (characterizing) a complete near-term solid-core NTP engine system in great detail, for a number of design options, in an efficient manner. The following discussion summarizes the overall analysis methodology, key assumptions, and capabilities associated with the NESS presents an example problem, and compares the results to related NTP engine system designs. Initial installation instructions and program disks are in Volume 2 of the NESS Program User's Guide.

Unifying theory for terrestrial research infrastructures

NASA Astrophysics Data System (ADS)

Mirtl, Michael

2016-04-01

The presentation will elaborate on basic steps needed for building a common theoretical base between Research Infrastructures focusing on terrestrial ecosystems. This theoretical base is needed for developing a better cooperation and integrating in the near future. An overview of different theories will be given and ways to a unifying approach explored. In the second step more practical implications of a theory-guided integration will be developed alongside the following guiding questions: • How do the existing and planned European environmental RIs map on a possible unifying theory on terrestrial ecosystems (covered structures and functions, scale; overlaps and gaps) • Can a unifying theory improve the consistent definition of RÍs scientific scope and focal science questions? • How could a division of tasks between RIs be organized in order to minimize parallel efforts? • Where concretely do existing and planned European environmental RIs need to interact to respond to overarching questions (top down component)? • What practical fora and mechanisms (across RIs) would be needed to bridge the gap between PI driven (bottom up) efforts and the centralistic RI design and operations?

Narrative Means to Preventative Ends: A Narrative Engagement Framework for Designing Prevention Interventions

PubMed Central

Miller-Day, Michelle; Hecht, Michael L.

2013-01-01

This paper describes a Narrative Engagement Framework (NEF) for guiding communication-based prevention efforts. This framework suggests that personal narratives have distinctive capabilities in prevention. The paper discusses the concept of narrative, links narrative to prevention, and discusses the central role of youth in developing narrative interventions. As illustration, the authors describe how the NEF is applied in the keepin’ it REAL adolescent drug prevention curriculum, pose theoretical directions, and offer suggestions for future work in prevention communication. PMID:23980613

Teaching and physics education research: bridging the gap.

PubMed

Fraser, James M; Timan, Anneke L; Miller, Kelly; Dowd, Jason E; Tucker, Laura; Mazur, Eric

2014-03-01

Physics faculty, experts in evidence-based research, often rely on anecdotal experience to guide their teaching practices. Adoption of research-based instructional strategies is surprisingly low, despite the large body of physics education research (PER) and strong dissemination effort of PER researchers and innovators. Evidence-based PER has validated specific non-traditional teaching practices, but many faculty raise valuable concerns toward their applicability. We address these concerns and identify future studies required to overcome the gap between research and practice.

DOD Education Benefits: Action Is Needed to Ensure Evaluations of Postsecondary Schools Are Useful

DTIC Science & Technology

2014-09-01

Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a...This program accommodates service members, who may regularly be reassigned to another location (including overseas), by allowing them to take classes...schools, but does not yet have a plan to guide future efforts. Absent a plan, it will be difficult for DOD to have all of the information it needs to

Reducing inequalities in cancer outcomes: what works?

PubMed

Bickell, Nina A; Paskett, Electra D

2013-01-01

Despite efforts to reduce disparities in cancer outcomes among vulnerable populations, certain subgroups do not experience the gains made in the reduction of cancer incidence and mortality. In this article, we review recent trial data reporting on patient-, physician-, and system-centered interventions to improve quality and reduce disparities in cancer care spanning patient navigation to health reform. We conclude with data from a state that implemented a multitiered approach, targeting patient and systems barriers, that serves as a guide for future endeavors.

Fun, Flow, and Fitness: Opinions for Making More Effective Active Videogames

PubMed Central

Mellecker, Robin; Buday, Richard; Gao, Zan; Hinkley, Trina; Esparza, Laura; Alexander, Shirley

2015-01-01

Abstract Despite active videogames' popularity and ability to increase a player's energy expenditure, research indicates their use sharply declines over time, which limits their utility in promoting physical activity. A frequent criticism is that a player's interest is quickly exhausted. At the preconference of the International Society of Behavioral Nutrition and Physical Activity 2014, a group of investigators and videogame developers gathered to share lessons learned from using serious videogames in health behavior change and offer insight to guide future efforts. PMID:26181681

Fun, Flow, and Fitness: Opinions for Making More Effective Active Videogames.

PubMed

Maloney, Ann E; Mellecker, Robin; Buday, Richard; Gao, Zan; Hinkley, Trina; Esparza, Laura; Alexander, Shirley

2015-02-01

Despite active videogames' popularity and ability to increase a player's energy expenditure, research indicates their use sharply declines over time, which limits their utility in promoting physical activity. A frequent criticism is that a player's interest is quickly exhausted. At the preconference of the International Society of Behavioral Nutrition and Physical Activity 2014, a group of investigators and videogame developers gathered to share lessons learned from using serious videogames in health behavior change and offer insight to guide future efforts.

The development of a diversity mentoring program for faculty and trainees: A program at the Brown Clinical Psychology Training Consortium

PubMed Central

de Dios, Marcel A.; Kuo, Caroline; Hernandez, Lynn; Clark, Uraina S.; Wenze, Susan J.; Boisseau, Christina L.; Hunter, Heather L.; Reddy, Madhavi K.; Tolou-Shams, Marina; Zlotnick, Caron

2013-01-01

There is a critical need for increasing the diversity representation among clinicians and researchers in academic medicine, including departments of psychiatry and psychology. Mentorship of under-represented groups has been identified as an important way to remediate diversity-related barriers in the field. This paper outlines the early development and pilot implementation of a diversity mentorship program at Brown University. In an effort to inform and guide future diversity programs, we discuss the challenges faced in creating the program, the successes experienced during the first year, and the future directions undertaken as a means for improving the program. PMID:25346563

Outline Guide to Educational Reform Initiatives. ERS Research Digest.

ERIC Educational Resources Information Center

Educational Research Service, Arlington, VA.

Many educational reform initiatives are being tried in an effort to restructure the American school system. This guide compares major educational reform efforts by goal, vision, teaching and learning, and system components. The first section of the guide covers major systemic educational reform initiatives, including Accelerated Schools Project,…

Communicating science in social settings.

PubMed

Scheufele, Dietram A

2013-08-20

This essay examines the societal dynamics surrounding modern science. It first discusses a number of challenges facing any effort to communicate science in social environments: lay publics with varying levels of preparedness for fully understanding new scientific breakthroughs; the deterioration of traditional media infrastructures; and an increasingly complex set of emerging technologies that are surrounded by a host of ethical, legal, and social considerations. Based on this overview, I discuss four areas in which empirical social science helps clarify intuitive but sometimes faulty assumptions about the social-level mechanisms of science communication and outline an agenda for bench and social scientists--driven by current social-scientific research in the field of science communication--to guide more effective communication efforts at the societal level in the future.

Communicating science in social settings

PubMed Central

Scheufele, Dietram A.

2013-01-01

This essay examines the societal dynamics surrounding modern science. It first discusses a number of challenges facing any effort to communicate science in social environments: lay publics with varying levels of preparedness for fully understanding new scientific breakthroughs; the deterioration of traditional media infrastructures; and an increasingly complex set of emerging technologies that are surrounded by a host of ethical, legal, and social considerations. Based on this overview, I discuss four areas in which empirical social science helps clarify intuitive but sometimes faulty assumptions about the social-level mechanisms of science communication and outline an agenda for bench and social scientists—driven by current social-scientific research in the field of science communication—to guide more effective communication efforts at the societal level in the future. PMID:23940341

Residential Fuel Cell Demonstration Handbook

NASA Astrophysics Data System (ADS)

Torrero, E.; McClelland, R.

2002-07-01

This report is a guide for rural electric cooperatives engaged in field testing of equipment and in assessing related application and market issues. Dispersed generation and its companion fuel cell technology have attracted increased interest by rural electric cooperatives and their customers. In addition, fuel cells are a particularly interesting source because their power quality, efficiency, and environmental benefits have now been coupled with major manufacturer development efforts. The overall effort is structured to measure the performance, durability, reliability, and maintainability of these systems, to identify promising types of applications and modes of operation, and to assess the related prospect for future use. In addition, technical successes and shortcomings will be identified by demonstration participants and manufacturers using real-world experience garnered under typical operating environments.

NASA Thermal Control Technologies for Robotic Spacecraft

NASA Technical Reports Server (NTRS)

Swanson, Theodore D.; Birur, Gajanana C.

2003-01-01

Technology development is inevitably a dynamic process in search of an elusive goal. It is never truly clear whether the need for a particular technology drives its development, or the existence of a new capability initiates new applications. Technology development for the thermal control of spacecraft presents an excellent example of this situation. Nevertheless, it is imperative to have a basic plan to help guide and focus such an effort. Although this plan will be a living document that changes with time to reflect technological developments, perceived needs, perceived opportunities, and the ever-changing funding environment, it is still a very useful tool. This presentation summarizes the current efforts at NASA/Goddard and NASA/JPL to develop new thermal control technology for future robotic NASA missions.

NASA ATP Force Measurement Technology Capability Strategic Plan

NASA Technical Reports Server (NTRS)

Rhew, Ray D.

2008-01-01

The Aeronautics Test Program (ATP) within the National Aeronautics and Space Administration (NASA) Aeronautics Research Mission Directorate (ARMD) initiated a strategic planning effort to re-vitalize the force measurement capability within NASA. The team responsible for developing the plan included members from three NASA Centers (Langley, Ames and Glenn) as well as members from the Air Force s Arnold Engineering and Development Center (AEDC). After visiting and discussing force measurement needs and current capabilities at each participating facility as well as selected force measurement companies, a strategic plan was developed to guide future NASA investments. This paper will provide the details of the strategic plan and include asset management, organization and technology research and development investment priorities as well as efforts to date.

Cigarettes, social reinforcement, and culture: a commentary on "Tobacco as a social currency: cigarette gifting and sharing in China".

PubMed

Ding, Ding; Hovell, Melbourne F

2012-03-01

As Rich and Xiao suggested, cigarette sharing and gifting play an important role in China's smoking epidemic. Understanding the cultural roots, history, and impacts of such practices should be emphasized in tobacco control efforts. "Tobacco as a social currency" is a consequence of the tobacco industry usurping traditional values and cultural customs to make cigarette gifting acceptable, desirable, and socially reinforcing. The cigarettes-social reinforcement link created by the tobacco industry can be broken by deglamorizing smoking and cigarette gifting and by reinforcing alternative healthful behaviors. A behavioral ecological perspective, with an emphasis of understanding and engineering cultures, should guide future health promotion efforts to reduce smoking and other risk practices in China.

Monitoring and evaluation of disaster response efforts undertaken by local health departments: a rapid realist review.

PubMed

Gossip, Kate; Gouda, Hebe; Lee, Yong Yi; Firth, Sonja; Bermejo, Raoul; Zeck, Willibald; Jimenez Soto, Eliana

2017-06-29

Local health departments are often at the forefront of a disaster response, attending to the immediate trauma inflicted by the disaster and also the long term health consequences. As the frequency and severity of disasters are projected to rise, monitoring and evaluation (M&E) efforts are critical to help local health departments consolidate past experiences and improve future response efforts. Local health departments often conduct M&E work post disaster, however, many of these efforts fail to improve response procedures. We undertook a rapid realist review (RRR) to examine why M&E efforts undertaken by local health departments do not always result in improved disaster response efforts. We aimed to complement existing frameworks by focusing on the most basic and pragmatic steps of a M&E cycle targeted towards continuous system improvements. For these purposes, we developed a theoretical framework that draws on the quality improvement literature to 'frame' the steps in the M&E cycle. This framework encompassed a M&E cycle involving three stages (i.e., document and assess, disseminate and implement) that must be sequentially completed to learn from past experiences and improve future disaster response efforts. We used this framework to guide our examination of the literature and to identify any context-mechanism-outcome (CMO) configurations which describe how M&E may be constrained or enabled at each stage of the M&E cycle. This RRR found a number of explanatory CMO configurations that provide valuable insights into some of the considerations that should be made when using M&E to improve future disaster response efforts. Firstly, to support the accurate documentation and assessment of a disaster response, local health departments should consider how they can: establish a culture of learning within health departments; use embedded training methods; or facilitate external partnerships. Secondly, to enhance the widespread dissemination of lessons learned and facilitate inter-agency learning, evaluation reports should use standardised formats and terminology. Lastly, to increase commitment to improvement processes, local health department leaders should possess positive leadership attributes and encourage shared decision making. This study is among the first to conduct a synthesis of the CMO configurations which facilitate or hinder M&E efforts aimed at improving future disaster responses. It makes a significant contribution to the disaster literature and provides an evidence base that can be used to provide pragmatic guidance for improving M&E efforts of local health departments. PROSPERO 2015: CRD42015023526 .

Biomarker-guided antibiotic therapy—strengths and limitations

PubMed Central

Salluh, Jorge; Martin-Loeches, Ignacio; Póvoa, Pedro

2017-01-01

Biomarkers as C-reactive protein (CRP) and procalcitonin (PCT) emerged as tools to help clinicians to diagnose infection and to properly initiate and define the duration of antibiotic therapy. Several randomized controlled trials, including adult critically ill patients, showed that PCT-guided antibiotic stewardship was repeatedly associated with a decrease in the duration of antibiotic therapy with no apparent harm. There are however some relevant limitations in these trials namely the low rate of compliance of PCT-guided algorithms, the high rate of exclusion (without including common clinical situations and pathogens) and the long duration of antibiotic therapy in control groups. Such limitations weakened the real impact of such algorithms in the clinical decision-making process and strengthened the concept that the initiation and the duration of antibiotic therapy cannot depend solely on a biomarker. Future efforts should address these limitations in order to better clarify the role of biomarkers on the complex and multifactorial issue of antibiotic management and to deeply understand its potential effect on mortality. PMID:28603723

Biomarker-guided antibiotic therapy-strengths and limitations.

PubMed

Nora, David; Salluh, Jorge; Martin-Loeches, Ignacio; Póvoa, Pedro

2017-05-01

Biomarkers as C-reactive protein (CRP) and procalcitonin (PCT) emerged as tools to help clinicians to diagnose infection and to properly initiate and define the duration of antibiotic therapy. Several randomized controlled trials, including adult critically ill patients, showed that PCT-guided antibiotic stewardship was repeatedly associated with a decrease in the duration of antibiotic therapy with no apparent harm. There are however some relevant limitations in these trials namely the low rate of compliance of PCT-guided algorithms, the high rate of exclusion (without including common clinical situations and pathogens) and the long duration of antibiotic therapy in control groups. Such limitations weakened the real impact of such algorithms in the clinical decision-making process and strengthened the concept that the initiation and the duration of antibiotic therapy cannot depend solely on a biomarker. Future efforts should address these limitations in order to better clarify the role of biomarkers on the complex and multifactorial issue of antibiotic management and to deeply understand its potential effect on mortality.

White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application.

PubMed

Barkhausen, Jörg; Kahn, Thomas; Krombach, Gabriele A; Kuhl, Christiane K; Lotz, Joachim; Maintz, David; Ricke, Jens; Schönberg, Stefan O; Vogl, Thomas J; Wacker, Frank K

2017-07-01

Background  MRI is attractive for the guiding and monitoring of interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure physiologic parameters like flow and cardiac function. Method  The current status of interventional MRI for the clinical routine was analyzed. Results  The effort needed for the development of MR-safe monitoring systems and instruments initially resulted in the application of interventional MRI only for procedures that could not be performed by other means. Accordingly, biopsy of lesions in the breast, which are not detectable by other modalities, has been performed under MRI guidance for decades. Currently, biopsies of the prostate under MRI guidance are established in a similar fashion. At many sites blind biopsy has already been replaced by MR-guided biopsy or at least by the fusion of MR images with ultrasound. Cardiovascular interventions are performed at several centers for ablation as a treatment for atrial fibrillation. Conclusion  Interventional MRI has been established in the clinical routine for a variety of indications. Broader application can be expected in the clinical routine in the future owing to the multiple advantages compared to other techniques. Key points   · Due to the significant technical effort, MR-guided interventions are only recommended in the long term for regions in which MRI either facilitates or greatly improves the intervention.. · Breast biopsy of otherwise undetectable target lesions has long been established in the clinical routine. Prostate biopsy is currently being introduced in the clinical routine for similar reasons. Other methods such as MR-guided focused ultrasound for the treatment of uterine fibroids or tumor ablation of metastases represent alternative methods and are offered in many places.. · Endovascular MR-guided interventions offer advantages for a number of indications and have already been clinically established for the treatment of children with congenital heart defects and for atrial ablation at individual centers. Greater application can be expected in the future.. Citation format · Barkhausen J, Kahn T, Krombach GA et al. White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application. Fortschr Röntgenstr 2017; 189: 611 - 623. © Georg Thieme Verlag KG Stuttgart · New York.

Fundamental constructs in food parenting practices: a content map to guide future research.

PubMed

Vaughn, Amber E; Ward, Dianne S; Fisher, Jennifer O; Faith, Myles S; Hughes, Sheryl O; Kremers, Stef P J; Musher-Eizenman, Dara R; O'Connor, Teresia M; Patrick, Heather; Power, Thomas G

2016-02-01

Although research shows that "food parenting practices" can impact children's diet and eating habits, current understanding of the impact of specific practices has been limited by inconsistencies in terminology and definitions. This article represents a critical appraisal of food parenting practices, including clear terminology and definitions, by a working group of content experts. The result of this effort was the development of a content map for future research that presents 3 overarching, higher-order food parenting constructs--coercive control, structure, and autonomy support--as well as specific practice subconstructs. Coercive control includes restriction, pressure to eat, threats and bribes, and using food to control negative emotions. Structure includes rules and limits, limited/guided choices, monitoring, meal- and snacktime routines, modeling, food availability and accessibility, food preparation, and unstructured practices. Autonomy support includes nutrition education, child involvement, encouragement, praise, reasoning, and negotiation. Literature on each construct is reviewed, and directions for future research are offered. Clear terminology and definitions should facilitate cross-study comparisons and minimize conflicting findings resulting from previous discrepancies in construct operationalization. © The Author(s) 2016. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Genetic Testing in the Multidisciplinary Management of Melanoma.

PubMed

Rashid, Omar M; Zager, Jonathan S

2015-10-01

Melanoma is increasing in incidence and represents an aggressive type of cancer. Efforts have focused on identifying genetic factors in melanoma carcinogenesis to guide prevention, screening, early detection, and targeted therapy. This article reviews the hereditary risk factors associated with melanoma and the known molecular pathways and genetic mutations associated with this disease. This article also explores the controversies associated with genetic testing and the latest advances in identifying genetic targets in melanoma, which offer promise for future application in the multidisciplinary management of melanoma. Copyright © 2015 Elsevier Inc. All rights reserved.

American Indian Substance Abuse Prevention Efforts: A Review of Programs, 2003-2013.

PubMed

Walsh, Margaret L; Baldwin, Julie A

2015-01-01

The purpose of the review was to assess substance abuse prevention (SAP) efforts in American Indian and Alaska Native (AI/AN) communities from 2003-2013. In the past, many SAP programs were unable to meet the unique cultural needs of AI/AN communities adequately. It has been suggested that a disconnect may exist between the theories that are used to guide development of prevention programs in AI/AN communities and culturally appropriate theoretical constructs of AI/AN worldviews. To explore this possible disconnect further, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to assess a total of 18 articles (N = 31 programs) on program location and method, participant characteristics, described program cultural elements, use of theory, program outcomes, program measures, and future recommendations. Results indicated that SAP programs in AI/AN communities vary widely in their use of theory, implementation strategies, view and definition of cultural constructs, overall evaluational rigor, and reporting methods. Future research is needed to integrate appropriate theory and cultural elements into SAP programs to tie them to measurable outcomes for AI/AN communities.

Geospatial considerations for a multiorganizational, landscape-scale program

USGS Publications Warehouse

O'Donnell, Michael S.; Assal, Timothy J.; Anderson, Patrick J.; Bowen, Zachary H.

2013-01-01

Geospatial data play an increasingly important role in natural resources management, conservation, and science-based projects. The management and effective use of spatial data becomes significantly more complex when the efforts involve a myriad of landscape-scale projects combined with a multiorganizational collaboration. There is sparse literature to guide users on this daunting subject; therefore, we present a framework of considerations for working with geospatial data that will provide direction to data stewards, scientists, collaborators, and managers for developing geospatial management plans. The concepts we present apply to a variety of geospatial programs or projects, which we describe as a “scalable framework” of processes for integrating geospatial efforts with management, science, and conservation initiatives. Our framework includes five tenets of geospatial data management: (1) the importance of investing in data management and standardization, (2) the scalability of content/efforts addressed in geospatial management plans, (3) the lifecycle of a geospatial effort, (4) a framework for the integration of geographic information systems (GIS) in a landscape-scale conservation or management program, and (5) the major geospatial considerations prior to data acquisition. We conclude with a discussion of future considerations and challenges.

Fiber Optic Force Sensors for MRI-Guided Interventions and Rehabilitation: A Review

PubMed Central

Iordachita, Iulian I.; Tokuda, Junichi; Hata, Nobuhiko; Liu, Xuan; Seifabadi, Reza; Xu, Sheng; Wood, Bradford; Fischer, Gregory S.

2017-01-01

Magnetic Resonance Imaging (MRI) provides both anatomical imaging with excellent soft tissue contrast and functional MRI imaging (fMRI) of physiological parameters. The last two decades have witnessed the manifestation of increased interest in MRI-guided minimally invasive intervention procedures and fMRI for rehabilitation and neuroscience research. Accompanying the aspiration to utilize MRI to provide imaging feedback during interventions and brain activity for neuroscience study, there is an accumulated effort to utilize force sensors compatible with the MRI environment to meet the growing demand of these procedures, with the goal of enhanced interventional safety and accuracy, improved efficacy and rehabilitation outcome. This paper summarizes the fundamental principles, the state of the art development and challenges of fiber optic force sensors for MRI-guided interventions and rehabilitation. It provides an overview of MRI-compatible fiber optic force sensors based on different sensing principles, including light intensity modulation, wavelength modulation, and phase modulation. Extensive design prototypes are reviewed to illustrate the detailed implementation of these principles. Advantages and disadvantages of the sensor designs are compared and analyzed. A perspective on the future development of fiber optic sensors is also presented which may have additional broad clinical applications. Future surgical interventions or rehabilitation will rely on intelligent force sensors to provide situational awareness to augment or complement human perception in these procedures. PMID:28652857

Biofuels: balancing risks and rewards.

PubMed

Thornley, Patricia; Gilbert, Paul

2013-02-06

This paper describes a framework that can be used to evaluate the environmental risks and benefits associated with biofuel production. It uses the example of biodiesel produced from Argentinean soy to show how such a framework can be used to conceptualize trade-offs between different environmental, social and economic impacts of biofuel production. Results showing the greenhouse-gas savings and overall life-cycle impact of different 'soy-biodiesel' production methods are presented. These impacts and the significance of uncertainty in overall assessments of key parameters, such as greenhouse-gas savings, are discussed. It is shown that, even where sufficient knowledge exists to be able to quantify these impacts, the sustainability of supply of a particular biofuel is inextricably linked to values and ethical judgements. However, tailoring certification efforts to the issues that are most likely to make a significant difference to the overall sustainability could improve the effectiveness of certification efforts. The potential for a framework to guide and focus certification efforts is discussed and future research and policy priorities suggested.

Co-Operative Advances in Behavioral Health and Performance Research and Operations

NASA Technical Reports Server (NTRS)

VanderArk, Stephen T.; Leveton, Lauren B.

2011-01-01

In organizations that engage in both operations and applied research, with operational needs guiding research questions and research informing improved operations, the ideal goal is a synergy of ideas and information. In reality, this ideal synergy is often lacking. Real-time operational needs driving day-to-day decisions, lack of communication, lag time in getting research advances plugged into operations can cause both areas to suffer from this gap between operations and research. At Johnson Space Center, the Behavior Health and Performance group (BHP) strives to bridge this gap by following a Human Research Program framework: Expectations of future operational needs identify the knowledge gaps; the gaps in turn guide research leading to a product that is transitioned into operations. Thus, the direction those of us in research take is in direct response to current and future needs of operations. Likewise, those of us in operations actively seek knowledge that is supported by evidence-based research. We make an ongoing effort to communicate across the research and operations gap by working closely with each other and making a conscious effort to keep each other informed. The objective of the proposed panel discussion is to demonstrate through the following presentations the results of a successful collaboration between research and operations and to provide ASMA members with more practical knowledge and strategies for building these bridges to serve our field of practice well. The panel will consist of six presenters from BHP operations, internal BHP research, and external research instigated by BHP who together represent the entire BHP Research Transition to Operations Framework

Genomic signals of selection predict climate-driven population declines in a migratory bird.

PubMed

Bay, Rachael A; Harrigan, Ryan J; Underwood, Vinh Le; Gibbs, H Lisle; Smith, Thomas B; Ruegg, Kristen

2018-01-05

The ongoing loss of biodiversity caused by rapid climatic shifts requires accurate models for predicting species' responses. Despite evidence that evolutionary adaptation could mitigate climate change impacts, evolution is rarely integrated into predictive models. Integrating population genomics and environmental data, we identified genomic variation associated with climate across the breeding range of the migratory songbird, yellow warbler ( Setophaga petechia ). Populations requiring the greatest shifts in allele frequencies to keep pace with future climate change have experienced the largest population declines, suggesting that failure to adapt may have already negatively affected populations. Broadly, our study suggests that the integration of genomic adaptation can increase the accuracy of future species distribution models and ultimately guide more effective mitigation efforts. Copyright © 2018, American Association for the Advancement of Science.

Human-computer interaction for alert warning and attention allocation systems of the multimodal watchstation

NASA Astrophysics Data System (ADS)

Obermayer, Richard W.; Nugent, William A.

2000-11-01

The SPAWAR Systems Center San Diego is currently developing an advanced Multi-Modal Watchstation (MMWS); design concepts and software from this effort are intended for transition to future United States Navy surface combatants. The MMWS features multiple flat panel displays and several modes of user interaction, including voice input and output, natural language recognition, 3D audio, stylus and gestural inputs. In 1999, an extensive literature review was conducted on basic and applied research concerned with alerting and warning systems. After summarizing that literature, a human computer interaction (HCI) designer's guide was prepared to support the design of an attention allocation subsystem (AAS) for the MMWS. The resultant HCI guidelines are being applied in the design of a fully interactive AAS prototype. An overview of key findings from the literature review, a proposed design methodology with illustrative examples, and an assessment of progress made in implementing the HCI designers guide are presented.

The Evidence-Based Principles of Negative Pressure Wound Therapy in Trauma & Orthopedics

PubMed Central

A, Novak; Khan, Wasim S; J, Palmer

2014-01-01

Negative pressure wound therapy is a popular treatment for the management of both acute and chronic wounds. Its use in trauma and orthopedics is diverse and includes the acute traumatic setting as well as chronic troublesome wounds associated with pressure sores and diabetic foot surgery. Efforts have been made to provide an evidence base to guide its use however this has been limited by a lack of good quality evidence. The following review article explores the available evidence and describes future developments for its use in trauma and orthopaedic practice. PMID:25067971

Manufacturing waste disposal practices of the chemical propulsion industry

NASA Technical Reports Server (NTRS)

Goldberg, Benjamin E.; Adams, Daniel E.; Schutzenhofer, Scott A.

1995-01-01

The waste production, mitigation and disposal practices of the United States chemical propulsion industry have been investigated, delineated, and comparatively assessed to the U.S. industrial base. Special emphasis has been placed on examination of ozone depleting chemicals (ODC's). The research examines present and anticipated future practices and problems encountered in the manufacture of solid and liquid propulsion systems. Information collected includes current environmental laws and regulations that guide the industry practices, processes in which ODC's are or have been used, quantities of waste produced, funding required to maintain environmentally compliant practices, and preventive efforts.

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.

PubMed

Bellen, Hugo J; Tong, Chao; Tsuda, Hiroshi

2010-07-01

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The use of an unparalleled wealth of tools, many of which originated between 1910–1960, has enabled milestone discoveries in nervous system development and function. Such findings have triggered and guided many research efforts in vertebrate neuroscience. After 100 years, fruit flies continue to be the choice model system for many neuroscientists. The combinational use of powerful research tools will ensure that this model organism will continue to lead to key discoveries that will impact vertebrate neuroscience.

HIV vaccine development: past, present and future.

PubMed

Robb, Merlin L

2010-12-01

The search for an HIV vaccine began following the discovery of the virus more than 25 years ago. Despite important progress, an effective vaccine remains an elusive goal that will likely require many more years of R&D to achieve. Following recent advances in research, however, there has been increased optimism that a prophylactic HIV vaccine is feasible. A consensus is forming among researchers to support a larger role for proof-of-concept efficacy clinical trials, conducted in parallel with invigorated basic research efforts and testing in animal models, to accelerate the discovery of key principles that will guide rational vaccine development.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raffray, A.R.; Meier, W.; Abdel-Khalik, S.

For thick liquid wall concepts, it is important to understand the different mechanisms affecting the chamber dynamics and the state of the chamber prior to each shot a compared with requirements from the driver and target. These include ablation mechanisms, vapor transport and control, possible aerosol formation, as well as protective jet behavior. This paper was motivated by a town meeting on this subject which helped identify the major issues, assess the latest results, review the capabilities of existing modeling and experimental facilities with respect to addressing remaining issues, and helping guide future analysis and R&D efforts; the paper coversmore » these exact points.« less

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

PubMed Central

Bellen, Hugo J; Tong, Chao; Tsuda, Hiroshi

2014-01-01

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The use of an unparalleled wealth of tools, many of which originated between 1910–1960, has enabled milestone discoveries in nervous system development and function. Such findings have triggered and guided many research efforts in vertebrate neuroscience. After 100 years, fruit flies continue to be the choice model system for many neuroscientists. The combinational use of powerful research tools will ensure that this model organism will continue to lead to key discoveries that will impact vertebrate neuroscience. PMID:20383202

A Student's Guide to Giant Viruses Infecting Small Eukaryotes: From Acanthamoeba to Zooxanthellae.

PubMed

Wilhelm, Steven W; Bird, Jordan T; Bonifer, Kyle S; Calfee, Benjamin C; Chen, Tian; Coy, Samantha R; Gainer, P Jackson; Gann, Eric R; Heatherly, Huston T; Lee, Jasper; Liang, Xiaolong; Liu, Jiang; Armes, April C; Moniruzzaman, Mohammad; Rice, J Hunter; Stough, Joshua M A; Tams, Robert N; Williams, Evan P; LeCleir, Gary R

2017-03-17

The discovery of infectious particles that challenge conventional thoughts concerning "what is a virus" has led to the evolution a new field of study in the past decade. Here, we review knowledge and information concerning "giant viruses", with a focus not only on some of the best studied systems, but also provide an effort to illuminate systems yet to be better resolved. We conclude by demonstrating that there is an abundance of new host-virus systems that fall into this "giant" category, demonstrating that this field of inquiry presents great opportunities for future research.

Women Shaping the Future. The Future of Work Discussion Kit.

ERIC Educational Resources Information Center

Pine, Janet; Jackson, Sue; MacNeill, Kate

Designed to inform and empower women to participate in debates and decisions about the future of work in Australia, this kit provides everything needed to run a discussion session on the future of work with women in the community. It consists of a guide for users, workshop guide, topic sheets, and background reading. The guide for users introduces…

Implementing Guided Pathways: Early Insights from the AACC Pathways Colleges

ERIC Educational Resources Information Center

Jenkins, Davis; Lahr, Hana; Fink, John

2017-01-01

Across the United States, a growing number of colleges are redesigning their programs and student support services according to the "guided pathways" model. Central to this approach are efforts to clarify pathways to program completion, career advancement, and further education. Equally essential are efforts to help students explore…

Community Resource Guide for Career Education.

ERIC Educational Resources Information Center

Melton, Dale H.

Ideas, examples, resources, and references for use by those interested in promoting collaborative educational efforts in their community are presented in this manual. Three major purposes of the guide are to bring together current materials on school-community cooperation; to assist in improving the quality of present collaborative efforts; and to…

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform.

PubMed

Marshall-Colon, Amy; Long, Stephen P; Allen, Douglas K; Allen, Gabrielle; Beard, Daniel A; Benes, Bedrich; von Caemmerer, Susanne; Christensen, A J; Cox, Donna J; Hart, John C; Hirst, Peter M; Kannan, Kavya; Katz, Daniel S; Lynch, Jonathan P; Millar, Andrew J; Panneerselvam, Balaji; Price, Nathan D; Prusinkiewicz, Przemyslaw; Raila, David; Shekar, Rachel G; Shrivastava, Stuti; Shukla, Diwakar; Srinivasan, Venkatraman; Stitt, Mark; Turk, Matthew J; Voit, Eberhard O; Wang, Yu; Yin, Xinyou; Zhu, Xin-Guang

2017-01-01

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance computing and mechanistic understanding of plant processes. Tools for guiding future crop breeding and engineering, understanding the implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem responses to the environment are urgently needed. The purpose of this perspective is to introduce Crops in silico (cropsinsilico.org), an integrative and multi-scale modeling platform, as one solution that combines isolated modeling efforts toward the generation of virtual crops, which is open and accessible to the entire plant biology community. The major challenges involved both in the development and deployment of a shared, multi-scale modeling platform, which are summarized in this prospectus, were recently identified during the first Crops in silico Symposium and Workshop.

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform

PubMed Central

Marshall-Colon, Amy; Long, Stephen P.; Allen, Douglas K.; Allen, Gabrielle; Beard, Daniel A.; Benes, Bedrich; von Caemmerer, Susanne; Christensen, A. J.; Cox, Donna J.; Hart, John C.; Hirst, Peter M.; Kannan, Kavya; Katz, Daniel S.; Lynch, Jonathan P.; Millar, Andrew J.; Panneerselvam, Balaji; Price, Nathan D.; Prusinkiewicz, Przemyslaw; Raila, David; Shekar, Rachel G.; Shrivastava, Stuti; Shukla, Diwakar; Srinivasan, Venkatraman; Stitt, Mark; Turk, Matthew J.; Voit, Eberhard O.; Wang, Yu; Yin, Xinyou; Zhu, Xin-Guang

2017-01-01

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate new hypotheses to prioritize directed engineering efforts. Outcomes will potentially accelerate improvement of crop yield, sustainability, and increase future food security. It is time for a paradigm shift in plant modeling, from largely isolated efforts to a connected community that takes advantage of advances in high performance computing and mechanistic understanding of plant processes. Tools for guiding future crop breeding and engineering, understanding the implications of discoveries at the molecular level for whole plant behavior, and improved prediction of plant and ecosystem responses to the environment are urgently needed. The purpose of this perspective is to introduce Crops in silico (cropsinsilico.org), an integrative and multi-scale modeling platform, as one solution that combines isolated modeling efforts toward the generation of virtual crops, which is open and accessible to the entire plant biology community. The major challenges involved both in the development and deployment of a shared, multi-scale modeling platform, which are summarized in this prospectus, were recently identified during the first Crops in silico Symposium and Workshop. PMID:28555150

Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper

PubMed Central

Thut, Gregor; Bergmann, Til Ole; Fröhlich, Flavio; Soekadar, Surjo R.; Brittain, John-Stuart; Valero-Cabré, Antoni; Sack, Alexander; Miniussi, Carlo; Antal, Andrea; Siebner, Hartwig Roman; Ziemann, Ulf; Herrmann, Christoph S.

2017-01-01

Non-invasive transcranial brain stimulation (NTBS) techniques have a wide range of applications but also suffer from a number of limitations mainly related to poor specificity of intervention and variable effect size. These limitations motivated recent efforts to focus on the temporal dimension of NTBS with respect to the ongoing brain activity. Temporal patterns of ongoing neuronal activity, in particular brain oscillations and their fluctuations, can be traced with electro- or magnetoencephalography (EEG/MEG), to guide the timing as well as the stimulation settings of NTBS. These novel, online and offline EEG/MEG-guided NTBS-approaches are tailored to specifically interact with the underlying brain activity. Online EEG/MEG has been used to guide the timing of NTBS (i.e., when to stimulate): by taking into account instantaneous phase or power of oscillatory brain activity, NTBS can be aligned to fluctuations in excitability states. Moreover, offline EEG/MEG recordings prior to interventions can inform researchers and clinicians how to stimulate: by frequency-tuning NTBS to the oscillation of interest, intrinsic brain oscillations can be up- or down-regulated. In this paper, we provide an overview of existing approaches and ideas of EEG/MEG-guided interventions, and their promises and caveats. We point out potential future lines of research to address challenges. PMID:28233641

The 1995 NASA guide to graduate support

NASA Technical Reports Server (NTRS)

1994-01-01

The future of the United States is in the classrooms of America and tomorrow's scientific and technological capabilities are derived from today's investments in research. In 1980, NASA initiated the Graduate Student Researchers Program (GSRP) to cultivate additional research ties to the academic community and to support promising students pursuing advanced degrees in science and engineering. Since then, approximately 1300 students have completed the program's requirements. In 1987, the program was expanded to include the Underrepresented Minority and Disabled Focus (UMDF) Component. This program was designed to increase participation of underrepresented groups in graduate study and research and, ultimately, in space science and aerospace technology careers. Approximately 270 minority students have completed the program's requirements while making significant contributions to the nation's aerospace efforts. Continuing to expand fellowship opportunities, NASA announced the Graduate Student Fellowships in Global Change Research in 1990. Designed to support the rapid growth in the study of earth as a system, more than 250 fellowships have been awarded. And, in 1992, NASA announced opportunities in the multiagency High Performance Computing and Communications (HPCC) Program designed to accelerate the development and application of massively parallel processing. Approximately five new fellowships will be awarded yearly. This booklet will guide you in your efforts to participate in programs for graduate student support.

Schools, Families, and the Prevention of Child Maltreatment: Lessons That Can Be Learned From a Literature Review.

PubMed

Admon Livny, Karen; Katz, Carmit

2018-04-01

Child maltreatment is a worldwide social problem that receives considerable attention. However, prevention efforts remain rare, allowing the phenomenon to continue and spread. The aim of the current article is to systematically review evidence-based prevention efforts that address schools and families as key stakeholders for preventing child maltreatment. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a thorough literature review revealed that only five programs matched the inclusion criteria for the current article. These programs were analyzed for several domains, including level of prevention, target population, participants, and the programs' outcomes. The current review highlights the urgent needs to develop, modify, and further evaluate prevention programs for child maltreatment in the context of the ecological model. More specifically, it illuminates the need to create and champion programs that enhance the collaboration between families and schools, both of which are key stakeholders within the phenomenon of child maltreatment. Collaboration between policymakers, researchers, and practitioners should guide future efforts by promoting cultural adaptation to such programs and by integrating children's perceptions to improve these efforts and to benefit everyone involved.

The Urgent Need for Improved Climate Models and Predictions

NASA Astrophysics Data System (ADS)

Goddard, Lisa; Baethgen, Walter; Kirtman, Ben; Meehl, Gerald

2009-09-01

An investment over the next 10 years of the order of US$2 billion for developing improved climate models was recommended in a report (http://wcrp.wmo.int/documents/WCRP_WorldModellingSummit_Jan2009.pdf) from the May 2008 World Modelling Summit for Climate Prediction, held in Reading, United Kingdom, and presented by the World Climate Research Programme. The report indicated that “climate models will, as in the past, play an important, and perhaps central, role in guiding the trillion dollar decisions that the peoples, governments and industries of the world will be making to cope with the consequences of changing climate.” If trillions of dollars are going to be invested in making decisions related to climate impacts, an investment of $2 billion, which is less than 0.1% of that amount, to provide better climate information seems prudent. One example of investment in adaptation is the World Bank's Climate Investment Fund, which has drawn contributions of more than $6 billion for work on clean technologies and adaptation efforts in nine pilot countries and two pilot regions. This is just the beginning of expenditures on adaptation efforts by the World Bank and other mechanisms, focusing on only a small fraction of the nations of the world and primarily aimed at anticipated anthropogenic climate change. Moreover, decisions are being made now, all around the world—by individuals, companies, and governments—that affect people and their livelihoods today, not just 50 or more years in the future. Climate risk management, whether related to projects of the scope of the World Bank's or to the planning and decisions of municipalities, will be best guided by meaningful climate information derived from observations of the past and model predictions of the future.

Solar Sail Models and Test Measurements Correspondence for Validation Requirements Definition

NASA Technical Reports Server (NTRS)

Ewing, Anthony; Adams, Charles

2004-01-01

Solar sails are being developed as a mission-enabling technology in support of future NASA science missions. Current efforts have advanced solar sail technology sufficient to justify a flight validation program. A primary objective of this activity is to test and validate solar sail models that are currently under development so that they may be used with confidence in future science mission development (e.g., scalable to larger sails). Both system and model validation requirements must be defined early in the program to guide design cycles and to ensure that relevant and sufficient test data will be obtained to conduct model validation to the level required. A process of model identification, model input/output documentation, model sensitivity analyses, and test measurement correspondence is required so that decisions can be made to satisfy validation requirements within program constraints.

The construct of resilience: Implications for interventions and social policies

PubMed Central

LUTHAR, SUNIYA S.; CICCHETTI, DANTE

2007-01-01

The focus of this article is on the interface between research on resilience—a construct representing positive adaptation despite adversity —and the applications of this work to the development of interventions and social policies. Salient defining features of research on resilience are delineated, as are various advantages, limitations, and precautions linked with the application of the resilience framework to developing interventions. For future applied efforts within this tradition, a series of guiding principles are presented along with exemplars of existing programs based on the resilience paradigm. The article concludes with discussions of directions for future work in this area, with emphases on an enhanced interface between science and practice, and a broadened scope of resilience-based interventions in terms of the types of populations, and the types of adjustment domains, that are encompassed. PMID:11202047

GSFC Information Systems Technology Developments Supporting the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Hughes, Peter; Dennehy, Cornelius; Mosier, Gary; Smith, Dan; Rykowski, Lisa

2004-01-01

The Vision for Space Exploration will guide NASA's future human and robotic space activities. The broad range of human and robotic missions now being planned will require the development of new system-level capabilities enabled by emerging new technologies. Goddard Space Flight Center is actively supporting the Vision for Space Exploration in a number of program management, engineering and technology areas. This paper provides a brief background on the Vision for Space Exploration and a general overview of potential key Goddard contributions. In particular, this paper focuses on describing relevant GSFC information systems capabilities in architecture development; interoperable command, control and communications; and other applied information systems technology/research activities that are applicable to support the Vision for Space Exploration goals. Current GSFC development efforts and task activities are presented together with future plans.

GSFC Ada programming guidelines

NASA Technical Reports Server (NTRS)

Roy, Daniel M.; Nelson, Robert W.

1986-01-01

A significant Ada effort has been under way at Goddard for the last two years. To ease the center's transition toward Ada (notably for future space station projects), a cooperative effort of half a dozen companies and NASA personnel was started in 1985 to produce programming standards and guidelines for the Ada language. The great richness of the Ada language and the need of programmers for good style examples makes Ada programming guidelines an important tool to smooth the Ada transition. Because of the natural divergence of technical opinions, the great diversity of our government and private organizations and the novelty of the Ada technology, the creation of an Ada programming guidelines document is a difficult and time consuming task. It is also a vital one. Steps must now be taken to ensure that the guide is refined in an organized but timely manner to reflect the growing level of expertise of the Ada community.

Using high-level construal and perceptions of changeability to promote self-change over self-protection motives in response to negative feedback.

PubMed

Belding, Jennifer N; Naufel, Karen Z; Fujita, Kentaro

2015-06-01

Diagnostic negative information presents people with a motivational dilemma. Although negative feedback can provide useful information with which to guide future self-improvement efforts, it also presents short-term affective costs. We propose that construal level, jointly with the perceived changeability of the feedback domain, determines whether people choose to accept or dismiss such information. Whereas low-level construal promotes short-term self-protection motivation (promoting dismissal), high-level construal promotes long-term self-change motivation (promoting acceptance)--to the extent that change is perceived as possible. Four studies support this hypothesis and examine underlying cognitive and motivational mechanisms. The present work may provide an integrative theoretical framework for understanding when people will be open to and accept negative diagnostic information, and has important practical implications for promoting self-change efforts. © 2015 by the Society for Personality and Social Psychology, Inc.

The current state of GPCR-based drug discovery to treat metabolic disease.

PubMed

Sloop, Kyle W; Emmerson, Paul J; Statnick, Michael A; Willard, Francis S

2018-02-02

One approach of modern drug discovery is to identify agents that enhance or diminish signal transduction cascades in various cell types and tissues by modulating the activity of GPCRs. This strategy has resulted in the development of new medicines to treat many conditions, including cardiovascular disease, psychiatric disorders, HIV/AIDS, certain forms of cancer and Type 2 diabetes mellitus (T2DM). These successes justify further pursuit of GPCRs as disease targets and provide key learning that should help guide identifying future therapeutic agents. This report reviews the current landscape of GPCR drug discovery with emphasis on efforts aimed at developing new molecules for treating T2DM and obesity. We analyse historical efforts to generate GPCR-based drugs to treat metabolic disease in terms of causal factors leading to success and failure in this endeavour. © 2018 The British Pharmacological Society.

Global biogeographic sampling of bacterial secondary metabolism

PubMed Central

Charlop-Powers, Zachary; Owen, Jeremy G; Reddy, Boojala Vijay B; Ternei, Melinda A; Guimarães, Denise O; de Frias, Ulysses A; Pupo, Monica T; Seepe, Prudy; Feng, Zhiyang; Brady, Sean F

2015-01-01

Recent bacterial (meta)genome sequencing efforts suggest the existence of an enormous untapped reservoir of natural-product-encoding biosynthetic gene clusters in the environment. Here we use the pyro-sequencing of PCR amplicons derived from both nonribosomal peptide adenylation domains and polyketide ketosynthase domains to compare biosynthetic diversity in soil microbiomes from around the globe. We see large differences in domain populations from all except the most proximal and biome-similar samples, suggesting that most microbiomes will encode largely distinct collections of bacterial secondary metabolites. Our data indicate a correlation between two factors, geographic distance and biome-type, and the biosynthetic diversity found in soil environments. By assigning reads to known gene clusters we identify hotspots of biomedically relevant biosynthetic diversity. These observations not only provide new insights into the natural world, they also provide a road map for guiding future natural products discovery efforts. DOI: http://dx.doi.org/10.7554/eLife.05048.001 PMID:25599565

Show me the numbers: What data currently exist for non-native species in the USA?

USGS Publications Warehouse

Crall, Alycia W.; Meyerson, Laura A.; Stohlgren, Thomas J.; Jarnevich, Catherine S.; Newman, Gregory J.; Graham, James

2006-01-01

Non-native species continue to be introduced to the United States from other countries via trade and transportation, creating a growing need for early detection and rapid response to new invaders. It is therefore increasingly important to synthesize existing data on non-native species abundance and distributions. However, no comprehensive analysis of existing data has been undertaken for non-native species, and there have been few efforts to improve collaboration. We therefore conducted a survey to determine what datasets currently exist for non-native species in the US from county, state, multi-state region, national, and global scales. We identified 319 datasets and collected metadata for 79% of these. Through this study, we provide a better understanding of extant non-native species datasets and identify data gaps (ie taxonomic, spatial, and temporal) to help guide future survey, research, and predictive modeling efforts.

Advances in the discovery of cathepsin K inhibitors on bone resorption.

PubMed

Lu, Jun; Wang, Maolin; Wang, Ziyue; Fu, Zhongqi; Lu, Aiping; Zhang, Ge

2018-12-01

Cathepsin K (Cat K), highly expressed in osteoclasts, is a cysteine protease member of the cathepsin lysosomal protease family and has been of increasing interest as a target of medicinal chemistry efforts for its role in bone matrix degradation. Inhibition of the Cat K enzyme reduces bone resorption and thus, has rendered the enzyme as an attractive target for anti-resorptive osteoporosis therapy. Over the past decades, considerable efforts have been made to design and develop highly potent, excellently selective and orally applicable Cat K inhibitors. These inhibitors are derived from synthetic compounds or natural products, some of which have passed preclinical studies and are presently in clinical trials at different stages of advancement. In this review, we briefly summarised the historic development of Cat K inhibitors and discussed the relationship between structures of inhibitors and active sites in Cat K for the purpose of guiding future development of inhibitors.

Variable Stars as an Introduction to Computational Research

NASA Astrophysics Data System (ADS)

Cash, Jennifer; Walter, Donald K.

2017-01-01

As a part of larger effort to enhance the research activity at SC State and involve more undergraduates in research activities, we present our efforts to develop an introductory research experience where the goal is a balance of astrophysical understanding, general research skills, and programming skills which the students can carry into a wide variety of future research activities. We have found that variable stars are a very good topic for this sort of introductory experience due to a combination of factors including: accessibility of data, easily understandable physical processes, and a relatively straight forward data analysis process. We will present an outline of our research experiences to guide a student from the very initial stages of learning to final presentation of the student's work.“This work was supported in part by NSF PAARE award AST-1358913 and NSF HBCU-UP award HRD-1332449 to SCSU.”

Cardiovascular Countermeasures for Exploration-Class Space Flight Missions

NASA Technical Reports Server (NTRS)

Charles, John B.

2004-01-01

Astronaut missions to Mars may be many years or even decades in thc future but current and planned efforts can be extrapolated to required treatments and prophylaxis for delerious efforts of prolonged space flight on the cardiovascular system. The literature of candidate countermeasures was considered in combination with unpublished plans for countermeasure implementation. The scope of cardiovascular countermeasures will be guided by assessments of the efficacy of mechanical, physiological and pharmacological approaches in protecting the cardiovascular capacities of interplanetary crewmembers. Plans for countermeasure development, evaluation and validation will exploit synergies among treatment modalities with the goal of maximizing protective effects while minimizing crew time and in-flight resource use. Protection of the cardiovascular capacity of interplanetary crewmembers will become more effective and efficient over the next few decades, but trade-offs between cost and effectiveness of efficiency are always possible if the increased level of risk can be accepted.

Automotive Technician II for ICT. Instructor's Guide, Curriculum Guide, and Student's Manual.

ERIC Educational Resources Information Center

Notgrass, Troy; Snider, Bob

The instructor's guide and curriculum guide contained in this packet are designed to help teachers provide future automotive technicians with some of the electronic skills they will need to service cars of the future. The instructor's guide is designed to help teachers make certain that each student gets the most benefit possible out of both the…

Engaging Stakeholders From Volunteer-Led Out-of-School Time Programs in the Dissemination of Guiding Principles for Healthy Snacking and Physical Activity.

PubMed

Folta, Sara C; Koomas, Alyssa; Metayer, Nesly; Fullerton, Karen J; Hubbard, Kristie L; Anzman-Frasca, Stephanie; Hofer, Teresa; Nelson, Miriam; Newman, Molly; Sacheck, Jennifer; Economos, Christina

2015-12-24

Little effort has focused on the role of volunteer-led out-of-school time (OST) programs (ie, enrichment and sports programs) as key environments for the promotion of healthy eating and physical activity habits among school-aged children. The Healthy Kids Out of School (HKOS) initiative developed evidence-based, practical guiding principles for healthy snacks, beverages, and physical activity. The goal of this case study was to describe the methods used to engage regional partners to understand how successful implementation and dissemination of these principles could be accomplished. HKOS partnered with volunteer-led programs from 5 OST organizations in Maine, Massachusetts, and New Hampshire to create a regional "learning laboratory." We engaged partners in phases. In the first phase, we conducted focus groups with local volunteer program leaders; during the second phase, we held roundtable meetings with regional and state program administrators; and in the final phase, we conducted additional outreach to refine and finalize implementation strategies. Implementation strategies were developed based on themes and information that emerged. For enrichment programs, strategies included new patch and pin programs that were consistent with the organizations' infrastructure and usual practices. For sports programs, the main strategy was integration with online trainings for coaches. Through the engagement process, we learned that dissemination of the guiding principles in these large and complex OST organizations was best accomplished by using implementation strategies that were customized, integrated, and aligned with goals and usual practices. The lessons learned can benefit future efforts to prevent obesity in complex environments.

A Review of the Experimental and Modeling Development of a Water Phase Change Heat Exchanger for Future Exploration Support Vehicles

NASA Technical Reports Server (NTRS)

Cognata, Thomas; Leimkuehler, Thomas; Ramaswamy, Balasubramaniam; Nayagam, Vedha; Hasan, Mohammad; Stephan, Ryan

2011-01-01

Water affords manifold benefits for human space exploration. Its properties make it useful for the storage of thermal energy as a Phase Change Material (PCM) in thermal control systems, in radiation shielding against Solar Particle Events (SPE) for the protection of crew members, and it is indisputably necessary for human life support. This paper envisions a single application for water which addresses these benefits for future exploration support vehicles and it describes recent experimental and modeling work that has been performed in order to arrive at a description of the thermal behavior of such a system. Experimental units have been developed and tested which permit the evaluation of the many parameters of design for such a system with emphasis on the latent energy content, temperature rise, mass, and interstitial material geometry. The experimental results are used to develop a robust and well correlated model which is intended to guide future design efforts toward the multi-purposed water PCM heat exchanger envisioned.

Choosing the Future You Prefer. A Goal Setting Guide.

ERIC Educational Resources Information Center

Lindaman, Edward B.; Lippitt, Ronald O.

The guide, intended for group and organization leaders, presents activities and exercises to aid in personal and group goal-setting and planning for the future. The objective is to help groups choose goals which are sensitive to and oriented toward the evolving future with its rapid rate of change. The guide is presented in eight chapters.…

Testing the Feasibility of Developmental Asset Measures on College Students to Guide Health Promotion Efforts

ERIC Educational Resources Information Center

Zullig, Keith J.; Ward, Rose Marie; King, Keith A.; Patton, Jon M.; Murray, Karen A.

2009-01-01

The purpose of this investigation was to assess the reliability and validity of eight developmental asset measures among a stratified, random sample (N = 540) of college students to guide health promotion efforts. The sample was randomly split to produce exploratory and confirmatory samples for factor analysis using principal axis factoring and…

NOAA's efforts to map extent, health and condition of deep sea corals and sponges and their habitat on the banks and island slopes of Southern California

NASA Astrophysics Data System (ADS)

Etnoyer, P. J.; Salgado, E.; Stierhoff, K.; Wickes, L.; Nehasil, S.; Kracker, L.; Lauermann, A.; Rosen, D.; Caldow, C.

2015-12-01

Southern California's deep-sea corals are diverse and abundant, but subject to multiple stressors, including corallivory, ocean acidification, and commercial bottom fishing. NOAA has surveyed these habitats using a remotely operated vehicle (ROV) since 2003. The ROV was equipped with high-resolution cameras to document deep-water groundfish and their habitat in a series of research expeditions from 2003 - 2011. Recent surveys 2011-2015 focused on in-situ measures of aragonite saturation and habitat mapping in notable habitats identified in previous years. Surveys mapped abundance and diversity of fishes and corals, as well as commercial fisheries landings and frequency of fishing gear. A novel priority setting algorithm was developed to identify hotspots of diversity and fishing intensity, and to determine where future conservation efforts may be warranted. High density coral aggregations identified in these analyses were also used to guide recent multibeam mapping efforts. The maps suggest a large extent of unexplored and unprotected hard-bottom habitat in the mesophotic zone and deep-sea reaches of Channel Islands National Marine Sanctuary.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2012-01-01

Although NASA is currently considering a number of future human space exploration mission concepts, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents the process and results of an effort to define a roadmap for Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro-gravity mission; 2) a long duration microgravity mission; and 3) a long duration partial gravity (surface) exploration mission. To organize the effort, a functional decomposition of ECLSS was completed starting with the three primary functions: atmosphere, water, and solid waste management. Each was further decomposed into sub-functions to the point that current state-of-the-art (SOA) technologies could be tied to the sub-function. Each technology was then assessed by NASA subject matter experts as to its ability to meet the functional needs of each of the three mission types. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capability needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions.

An evolutionary perspective on health psychology: new approaches and applications.

PubMed

Tybur, Joshua M; Bryan, Angela D; Hooper, Ann E Caldwell

2012-12-20

Although health psychologists' efforts to understand and promote health are most effective when guided by theory, health psychology has not taken full advantage of theoretical insights provided by evolutionary psychology. Here, we argue that evolutionary perspectives can fruitfully inform strategies for addressing some of the challenges facing health psychologists. Evolutionary psychology's emphasis on modular, functionally specialized psychological systems can inform approaches to understanding the myriad behaviors grouped under the umbrella of "health," as can theoretical perspectives used by evolutionary anthropologists, biologists, and psychologists (e.g., Life History Theory). We detail some early investigations into evolutionary health psychology, and we provide suggestions for directions for future research.

A Student’s Guide to Giant Viruses Infecting Small Eukaryotes: From Acanthamoeba to Zooxanthellae

PubMed Central

Wilhelm, Steven W.; Bird, Jordan T.; Bonifer, Kyle S.; Calfee, Benjamin C.; Chen, Tian; Coy, Samantha R.; Gainer, P. Jackson; Gann, Eric R.; Heatherly, Huston T.; Lee, Jasper; Liang, Xiaolong; Liu, Jiang; Armes, April C.; Moniruzzaman, Mohammad; Rice, J. Hunter; Stough, Joshua M. A.; Tams, Robert N.; Williams, Evan P.; LeCleir, Gary R.

2017-01-01

The discovery of infectious particles that challenge conventional thoughts concerning “what is a virus” has led to the evolution a new field of study in the past decade. Here, we review knowledge and information concerning “giant viruses”, with a focus not only on some of the best studied systems, but also provide an effort to illuminate systems yet to be better resolved. We conclude by demonstrating that there is an abundance of new host–virus systems that fall into this “giant” category, demonstrating that this field of inquiry presents great opportunities for future research. PMID:28304329

AFRICAN-AMERICANS’ AND LATINOS’ PERCEPTIONS OF USING HYPNOSIS TO ALLEVIATE DISTRESS BEFORE A COLONOSCOPY

PubMed Central

Miller, Sarah J.; Schnur, Julie B.; Montgomery, Guy H.; Jandorf, Lina

2013-01-01

Although colorectal cancer (CRC) screenings can effectively detect and prevent cancer, a large portion of African-Americans and Latinos do not undergo regular colonoscopy screening. Research suggests that anticipatory distress can significantly hinder minorities’ adherence to colonoscopy recommendations. There is significant promise that hypnosis may effectively reduce such distress. The current study examined African-Americans’ and Latinos’ (n = 213) perceptions of using hypnosis prior to a colonoscopy. Overall, 69.9% of the sample expressed favourable perceptions of using pre-colonoscopy hypnosis, although there was notable variability. The results from this study can guide clinical decision making and inform future research efforts. PMID:26566440

West Virginia Interpretive Guide Training: A Collaborative Effort

ERIC Educational Resources Information Center

Balcarczyk, Kelly; McKenney, Kathryn; Smaldone, Dave; Arborgast, Doug

2013-01-01

West Virginia University's Extension Service partnered with the Recreation, Parks, and Tourism Resources Program to improve guide performance in West Virginia's tourism industry. The result of this partnership is a West Virginia Interpretive Guide Training program aimed at providing low-cost, widely available training to guides throughout the…

Physical activity guides for Canadians: messaging strategies, realistic expectations for change, and evaluation.

PubMed

Brawley, Lawrence R; Latimer, Amy E

2007-01-01

Physical activity guidelines offer evidence-based behavioural benchmarks that relate to reduced risk of morbidity and mortality if people adhere to them. Essentially, the guidelines tell people what to do, but not why and how they should do it. Thus, to motivate adherence, messages that translate guidelines should convey not only how much physical activity one should attempt and why it is recommended, but also how to achieve such a recommendation. Canada's physical activity guides exemplify how guidelines can be translated. This paper (i) provides a brief overview of the challenges encountered in creating the existing guides and (ii) highlights important practical issues and empirical evidence that should be considered in the future when translating guidelines into messages and disseminating these messages. We draw on the successes of past efforts to translate the goals of physical activity guidelines and on recent literature on messages and media campaigns to make recommendations. Information to motivate people to move toward the goals in physical activity guidelines should be translated into a set of messages that are informative, thought provoking, and persuasive. These messages should be disseminated to the public via a multi-phase social-marketing campaign that is carefully planned and thoroughly evaluated.

Quantum theory for 1D X-ray free electron laser

DOE PAGES

Anisimov, Petr Mikhaylovich

2017-09-19

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classicalmore » theory, which allows for immediate transfer of knowledge between the two regimes. In conclusion, we exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.« less

Quantum theory for 1D X-ray free electron laser

NASA Astrophysics Data System (ADS)

Anisimov, Petr M.

2018-06-01

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classical theory, which allows for immediate transfer of knowledge between the two regimes. We exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anisimov, Petr Mikhaylovich

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classicalmore » theory, which allows for immediate transfer of knowledge between the two regimes. In conclusion, we exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.« less

Keytag It: An Exploration of a Creative and Customizable Research Guide Promotion

ERIC Educational Resources Information Center

Roseberry, Martha; Peacemaker, Bettina

2016-01-01

The research guide is a common tool librarians use to communicate with and instruct their audiences. Despite their prevalence and value to users, research guides remain underused. There are many examples of efforts encouraging guide use, but few studies have measured the effectiveness of that promotion. Academic Outreach librarians at Virginia…

Optimal allocation of Red List assessments to guide conservation of biodiversity in a rapidly changing world.

PubMed

Hermoso, Virgilio; Januchowski-Hartley, Stephanie Renee; Linke, Simon; Dudgeon, David; Petry, Paulo; McIntyre, Peter

2017-09-01

The IUCN Red List is the most extensive source of conservation status assessments for species worldwide, but important gaps in coverage remain. Here, we demonstrate the use of a spatial prioritization approach to efficiently prioritize species assessments to achieve increased and up-to-date coverage efficiently. We focus on freshwater fishes, which constitute a significant portion of vertebrate diversity, although comprehensive assessments are available for only 46% of species. We used marxan to identify ecoregions for future assessments that maximize the coverage of species while accounting for anthropogenic stress. We identified a set of priority regions that would help assess one-third (ca 4000 species) of all freshwater fishes in need of assessment by 2020. Such assessments could be achieved without increasing current investment levels. Our approach is suitable for any taxon and can help ensure that species threat assessments are sufficiently complete to guide global conservation efforts in a rapidly changing world. © 2017 John Wiley & Sons Ltd.

ChemTrove: enabling a generic ELN to support chemistry through the use of transferable plug-ins and online data sources.

PubMed

Day, Aileen E; Coles, Simon J; Bird, Colin L; Frey, Jeremy G; Whitby, Richard J; Tkachenko, Valery E; Williams, Antony J

2015-03-23

In designing an Electronic Lab Notebook (ELN), there is a balance to be struck between keeping it as general and multidisciplinary as possible for simplicity of use and maintenance and introducing more domain-specific functionality to increase its appeal to target research areas. Here, we describe the results of a collaboration between the Royal Society of Chemistry (RSC) and the University of Southampton, guided by the aims of the Dial-a-Molecule Grand Challenge, intended to achieve the best of both worlds and augment a discipline-agnostic ELN, LabTrove, with chemistry-specific functionality and using data provided by the ChemSpider platform. This has been done using plug-in technology to ensure maximum transferability with minimal effort of the chemistry functionality to other ELNs and equally other subject-specific functionality to LabTrove. The resulting product, ChemTrove, has undergone a usability trial by selected academics, and the resulting feedback will guide the future development of the underlying ELN technology.

Computer-Aided Nodule Assessment and Risk Yield Risk Management of Adenocarcinoma: The Future of Imaging?

PubMed

Foley, Finbar; Rajagopalan, Srinivasan; Raghunath, Sushravya M; Boland, Jennifer M; Karwoski, Ronald A; Maldonado, Fabien; Bartholmai, Brian J; Peikert, Tobias

2016-01-01

Increased clinical use of chest high-resolution computed tomography results in increased identification of lung adenocarcinomas and persistent subsolid opacities. However, these lesions range from very indolent to extremely aggressive tumors. Clinically relevant diagnostic tools to noninvasively risk stratify and guide individualized management of these lesions are lacking. Research efforts investigating semiquantitative measures to decrease interrater and intrarater variability are emerging, and in some cases steps have been taken to automate this process. However, many such methods currently are still suboptimal, require validation and are not yet clinically applicable. The computer-aided nodule assessment and risk yield software application represents a validated tool for the automated, quantitative, and noninvasive tool for risk stratification of adenocarcinoma lung nodules. Computer-aided nodule assessment and risk yield correlates well with consensus histology and postsurgical patient outcomes, and therefore may help to guide individualized patient management, for example, in identification of nodules amenable to radiological surveillance, or in need of adjunctive therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

CANARY Risk Management of Adenocarcinoma: The Future of Imaging?

PubMed Central

Foley, Finbar; Rajagopalan, Srinivasan; Raghunath, Sushravya M; Boland, Jennifer M; Karwoski, Ronald A.; Maldonado, Fabien; Bartholmai, Brian J; Peikert, Tobias

2016-01-01

Increased clinical utilization of chest high resolution computed tomography results in increased identification of lung adenocarcinomas and persistent sub-solid opacities. However, these lesions range from very indolent to extremely aggressive tumors. Clinically relevant diagnostic tools to non-invasively risk stratify and guide individualized management of these lesions are lacking. Research efforts investigating semi-quantitative measures to decrease inter- and intra-rater variability are emerging, and in some cases steps have been taken to automate this process. However, many such methods currently are still sub-optimal, require validation and are not yet clinically applicable. The Computer-Aided Nodule Assessment and Risk Yield (CANARY) software application represents a validated tool for the automated, quantitative, non-invasive tool for risk stratification of adenocarcinoma lung nodules. CANARY correlates well with consensus histology and post-surgical patient outcomes and therefore may help to guide individualized patient management e.g. in identification of nodules amenable to radiological surveillance, or in need of adjunctive therapy. PMID:27568149

Motivational Pathways to STEM Career Choices: Using Expectancy-Value Perspective to Understand Individual and Gender Differences in STEM Fields.

PubMed

Wang, Ming-Te; Degol, Jessica

2013-12-01

The United States has made a significant effort and investment in STEM education, yet the size and the composition of the STEM workforce continues to fail to meet demand. It is thus important to understand the barriers and factors that influence individual educational and career choices. In this article, we conduct a literature review of the current knowledge surrounding individual and gender differences in STEM educational and career choices, using expectancy-value theory as a guiding framework. The overarching goal of this paper is to provide both a well-defined theoretical framework and complementary empirical evidence for linking specific sociocultural, contextual, biological, and psychological factors to individual and gender differences in STEM interests and choices. Knowledge gained through this review will eventually guide future research and interventions designed to enhance individual motivation and capacity to pursue STEM careers, particularly for females who are interested in STEM but may be constrained by misinformation or stereotypes.

A Deterministic Model to Quantify Risk and Guide Mitigation Strategies to Reduce Bluetongue Virus Transmission in California Dairy Cattle

PubMed Central

Mayo, Christie; Shelley, Courtney; MacLachlan, N. James; Gardner, Ian; Hartley, David; Barker, Christopher

2016-01-01

The global distribution of bluetongue virus (BTV) has been changing recently, perhaps as a result of climate change. To evaluate the risk of BTV infection and transmission in a BTV-endemic region of California, sentinel dairy cows were evaluated for BTV infection, and populations of Culicoides vectors were collected at different sites using carbon dioxide. A deterministic model was developed to quantify risk and guide future mitigation strategies to reduce BTV infection in California dairy cattle. The greatest risk of BTV transmission was predicted within the warm Central Valley of California that contains the highest density of dairy cattle in the United States. Temperature and parameters associated with Culicoides vectors (transmission probabilities, carrying capacity, and survivorship) had the greatest effect on BTV’s basic reproduction number, R0. Based on these analyses, optimal control strategies for reducing BTV infection risk in dairy cattle will be highly reliant upon early efforts to reduce vector abundance during the months prior to peak transmission. PMID:27812161

Refocussing our attention on 'need' in the application of telehealth.

PubMed

Scott, Richard E; Affleck-Hall, Louise C; Mars, Maurice

2014-01-01

Given that e-health (including telehealth) is an opportunity cost (i.e., redirecting already scarce healthcare resources away from more traditional healthcare delivery needs), performing needs assessment ensures that investment of resources in e-health is appropriate. Yet the current literature shows research is on clever, narrow, or 'one disease' telehealth applications (e.g., telediabetes; telesurgery), or creation of electronic records (e.g., EHR's; EMRs; HIS's) and accumulation of 'big data' (e.g. biosurveillance). Given the reality of comorbidity, the complexity of telesurgery, and the lack of successful country-wide EHR implementations, are we using our investments in e-health wisely? The requirement for needs assessment to guide selection and implementation of evidence-based and needs-based e-health solutions is seldom adhered to. We must refocus our efforts on more pragmatic needs. Where might insight to evidence-based health needs come from? Using South Africa as an example, this paper highlights several readily available resources, and how they may guide future telehealth implementations in South Africa and elsewhere.

Risk Factors and Biomarkers of Age-Related Macular Degeneration

PubMed Central

Lambert, Nathan G.; Singh, Malkit K.; ElShelmani, Hanan; Mansergh, Fiona C.; Wride, Michael A.; Padilla, Maximilian; Keegan, David; Hogg, Ruth E.; Ambati, Balamurali K.

2016-01-01

A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings. PMID:27156982

The Guide to Better Hospital Computer Decisions

PubMed Central

Dorenfest, Sheldon I.

1981-01-01

A soon-to-be-published major study of hospital computer use entitled “The Guide to Better Hospital Computer Decisions” was conducted by my firm over the past 2½ years. The study required over twenty (20) man years of effort at a cost of over $300,000, and the six (6) volume final report provides more than 1,000 pages of data about how hospitals are and will be using computerized medical and business information systems. It describes the current status and future expectations for computer use in major application areas, such as, but not limited to, finance, admitting, pharmacy, laboratory, data collection and hospital or medical information systems. It also includes profiles of over 100 companies and other types of organizations providing data processing products and services to hospitals. In this paper, we discuss the need for the study, the specific objectives of the study, the methodology and approach taken to complete the study and a few major conclusions.

Motivational Pathways to STEM Career Choices: Using Expectancy-Value Perspective to Understand Individual and Gender Differences in STEM Fields

PubMed Central

Wang, Ming-Te; Degol, Jessica

2013-01-01

The United States has made a significant effort and investment in STEM education, yet the size and the composition of the STEM workforce continues to fail to meet demand. It is thus important to understand the barriers and factors that influence individual educational and career choices. In this article, we conduct a literature review of the current knowledge surrounding individual and gender differences in STEM educational and career choices, using expectancy-value theory as a guiding framework. The overarching goal of this paper is to provide both a well-defined theoretical framework and complementary empirical evidence for linking specific sociocultural, contextual, biological, and psychological factors to individual and gender differences in STEM interests and choices. Knowledge gained through this review will eventually guide future research and interventions designed to enhance individual motivation and capacity to pursue STEM careers, particularly for females who are interested in STEM but may be constrained by misinformation or stereotypes. PMID:24298199

Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making.

PubMed

Fervaha, Gagan; Graff-Guerrero, Ariel; Zakzanis, Konstantine K; Foussias, George; Agid, Ofer; Remington, Gary

2013-11-01

Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. Sixteen stable outpatients with schizophrenia and sixteen matched healthy controls completed a modified version of the Effort Expenditure for Rewards Task that accounts for differences in motoric ability. Briefly, subjects were presented with a series of trials where they may choose to expend a greater amount of effort for a larger monetary reward versus less effort for a smaller reward. Additionally, the probability of receiving money for a given trial was varied at 12%, 50% and 88%. Clinical and other reward-related variables were also evaluated. Patients opted to expend greater effort significantly less than controls for trials of high, but uncertain (i.e. 50% and 88% probability) incentive value, which was related to amotivation and neurocognitive deficits. Other abnormalities were also noted but were related to different clinical variables such as impulsivity (low reward and 12% probability). These motivational deficits were not due to group differences in reward learning, reward valuation or hedonic capacity. Our findings offer novel support for incentive motivation deficits in schizophrenia. Clinical amotivation is associated with impairments in the computation of effort during cost-benefit decision-making. This objective translational paradigm may guide future investigations of the neural circuitry underlying these motivational impairments. Copyright © 2013 Elsevier Ltd. All rights reserved.

The ICER Value Framework: Integrating Cost Effectiveness and Affordability in the Assessment of Health Care Value.

PubMed

Pearson, Steven D

2018-03-01

What should be the relationship between the concepts of cost effectiveness and affordability in value assessments for health care interventions? This question has received greater attention in recent years given increasing financial pressures on health systems, leading to different views on how assessment reports and decision-making processes can provide the best structure for considering both elements. In the United States, the advent of explicit value frameworks to guide drug assessments has also focused attention on this issue, driven in part by the prominent inclusion of affordability within the value framework used to guide reports from the Institute for Clinical and Economic Review. After providing a formal definition of affordability for health care systems, this article argues that, even after using empirical estimates of true health system opportunity cost, cost-effectiveness thresholds cannot by themselves be set in a way that subsumes questions about short-term affordability. The article then presents an analysis of different approaches to integrating cost effectiveness and budget impact assessments within information to guide decision making. The evolution and experience with the Institute for Clinical and Economic Review value framework are highlighted, providing lessons learned and guiding principles for future efforts to bring measures of affordability within the scope of value assessment. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

What Happened to the World? Helping Children Cope in Turbulent Times. Facilitator's Guide [and Student's Guide].

ERIC Educational Resources Information Center

Greenman, Jim

In response to the September 11th, 2001 terrorists attacks, "Comfort for Kids" was formed as a collaborative effort to provide support and resources to children and families directly affected. This facilitator's guide and student's guide represent one part of the three-pronged approach of the "Comfort for Kids" program. The…

New Library, New Librarian, New Student: Using LibGuides to Reach the Virtual Student

ERIC Educational Resources Information Center

Roberts, Sara; Hunter, Dwight

2011-01-01

This article examines the virtual pathfinder and its relationship with distance education students. Various topics are addressed in relation to virtual students, LibGuides and collaborative efforts between librarians and teaching faculty. A brief history of the subject guide is presented, advantages and disadvantages of LibGuides are discussed and…

Study of the Application of Separation Control by Unsteady Excitation to Civil Transport Aircraft

NASA Technical Reports Server (NTRS)

McLean, J. D.; Crouch, J. D.; Stoner, R. C.; Sakurai, S.; Seidel, G. E.; Feifel, W. M.; Rush, H. M.

1999-01-01

This study provides a preliminary assessment of the potential benefits of applying unsteady separation control to transport aircraft. Estimates are given for some of the costs associated with a specific application to high-lift systems. High-leverage areas for future research were identified during the course of the study. The study was conducted in three phases. Phase 1 consisted of a coarse screening of potential applications within the aerodynamics discipline. Potential benefits were identified and in some cases quantified in a preliminary way. Phase 2 concentrated on the application to the wing high-lift system, deemed to have the greatest potential benefit for commercial transports. A team of experts, including other disciplines (i.e. hydraulic, mechanical, and electrical systems, structures, configurations, manufacturing, and finance), assessed the feasibility, benefits, and costs to arrive at estimates of net benefits. In both phases of the study, areas of concern and areas for future research were identified. In phase 3 of this study, the high-leverage areas for future research were prioritized as a guide for future efforts aimed at the application of active flow control to commercial transport aircraft.

Discovering eHealth Technology: An Innovative Interprofessional Graduate Student Learning Experience.

PubMed

Estes, Krista; Gilliam, Eric; Knapfel, Sarah; Lee, Chanmi; Skiba, Diane

2016-01-01

The use of eHealth has grown in recent years and is projected to continue to increase exponentially. In order to empower and prepare advanced practice providers to integrate eHealth into their clinical practice, curricular changes need to occur. The iTEAM grant provides a unique opportunity to prepare advanced practice disciplines to provide collaborative care using eHealth. Through the integration of a simulated telehealth using a standardized patient, Doctor of Pharmacy and Advanced Practice Registered Nursing students learned how to apply health information technology and coordinate care in an interprofessional manner. Opportunities and challenges to guide future efforts to integrate eHealth-learning experiences into the curriculum are identified.

Computational modeling of epidermal cell fate determination systems.

PubMed

Ryu, Kook Hui; Zheng, Xiaohua; Huang, Ling; Schiefelbein, John

2013-02-01

Cell fate decisions are of primary importance for plant development. Their simple 'either-or' outcome and dynamic nature has attracted the attention of computational modelers. Recent efforts have focused on modeling the determination of several epidermal cell types in the root and shoot of Arabidopsis where many molecular components have been defined. Results of integrated modeling and molecular biology experimentation in these systems have highlighted the importance of competitive positive and negative factors and interconnected feedback loops in generating flexible yet robust mechanisms for establishing distinct gene expression programs in neighboring cells. These models have proven useful in judging hypotheses and guiding future research. Copyright © 2012 Elsevier Ltd. All rights reserved.

Remarks on the maximum luminosity

NASA Astrophysics Data System (ADS)

Cardoso, Vitor; Ikeda, Taishi; Moore, Christopher J.; Yoo, Chul-Moon

2018-04-01

The quest for fundamental limitations on physical processes is old and venerable. Here, we investigate the maximum possible power, or luminosity, that any event can produce. We show, via full nonlinear simulations of Einstein's equations, that there exist initial conditions which give rise to arbitrarily large luminosities. However, the requirement that there is no past horizon in the spacetime seems to limit the luminosity to below the Planck value, LP=c5/G . Numerical relativity simulations of critical collapse yield the largest luminosities observed to date, ≈ 0.2 LP . We also present an analytic solution to the Einstein equations which seems to give an unboundedly large luminosity; this will guide future numerical efforts to investigate super-Planckian luminosities.

Networks to Strengthen Health Systems for Chronic Disease Prevention

PubMed Central

Riley, Barbara L.; Herbert, Carol P.; Best, Allan

2013-01-01

Interorganizational networks that harness the priorities, capacities, and skills of various agencies and individuals have emerged as useful approaches for strengthening preventive services in public health systems. We use examples from the Canadian Heart Health Initiative and Alberta’s Primary Care Networks to illustrate characteristics of networks, describe the limitations of existing frameworks for assessing the performance of prevention-oriented networks, and propose a research agenda for guiding future efforts to improve the performance of these initiatives. Prevention-specific assessment strategies that capture relevant aspects of network performance need to be identified, and feedback mechanisms are needed that make better use of these data to drive change in network activities. PMID:24028225

High Efficiency Centrifugal Compressor for Rotorcraft Applications

NASA Technical Reports Server (NTRS)

Medic, Gorazd; Sharma, Om P.; Jongwook, Joo; Hardin, Larry W.; McCormick, Duane C.; Cousins, William T.; Lurie, Elizabeth A.; Shabbir, Aamir; Holley, Brian M.; Van Slooten, Paul R.

2017-01-01

A centrifugal compressor research effort conducted by United Technologies Research Center under NASA Research Announcement NNC08CB03C is documented. The objectives were to identify key technical barriers to advancing the aerodynamic performance of high-efficiency, high work factor, compact centrifugal compressor aft-stages for turboshaft engines; to acquire measurements needed to overcome the technical barriers and inform future designs; to design, fabricate, and test a new research compressor in which to acquire the requisite flow field data. A new High-Efficiency Centrifugal Compressor stage -- splittered impeller, splittered diffuser, 90 degree bend, and exit guide vanes -- with aerodynamically aggressive performance and configuration (compactness) goals were designed, fabricated, and subquently tested at the NASA Glenn Research Center.

Universally-Usable Interactive Electronic Physics Instructional And Educational Materials

NASA Astrophysics Data System (ADS)

Gardner, John

2000-03-01

Recent developments of technologies that promote full accessibility of electronic information by future generations of people with print disabilities will be described. ("Print disabilities" include low vision, blindness, and dyslexia.) The guiding philosophy of these developments is that information should be created and transmitted in a form that is as display-independent as possible, and that the user should have maximum freedom over how that information is to be displayed. This philosophy leads to maximum usability by everybody and is, in the long run, the only way to assure truly equal access. Research efforts to be described include access to mathematics and scientific notation and to graphs, tables, charts, diagrams, and general object-oriented graphics.

Nuclear-bound quarkonia and heavy-flavor hadrons

NASA Astrophysics Data System (ADS)

Krein, G.; Thomas, A. W.; Tsushima, K.

2018-05-01

In our quest to win a deeper understanding of how QCD actually works, the study of the binding of heavy quarkonia and heavy-flavor hadrons to atomic nuclei offers enormous promise. Modern experimental facilities such as FAIR, Jefferson Lab at 12 GeV and J-PARC offer exciting new experimental opportunities to study such systems. These experimental advances are complemented by new theoretical approaches and predictions, which will both guide these experimental efforts and be informed and improved by them. This review will outline the main theoretical approaches, beginning with QCD itself, summarize recent theoretical predictions and relate them both to past experiments and those from which we may expect results in the near future.

The South Carolina LGBT needs assessment: a descriptive overview.

PubMed

Coleman, Jason D; Irwin, Jay A; Wilson, Ryan C; Miller, Henry C

2014-01-01

Limited quantitative information exists about the demographics and needs of lesbian, gay, bisexual, and transgender (LGBT) persons in South Carolina, a predominately rural Southern state. Responses to a needs assessment survey (n = 715) were analyzed to understand the diversity and needs of members of the LGBT community in SC. The purpose was to inform future programming and guide the development of a more comprehensive portfolio of services to be offered by a local LGBT community center. Findings suggest that a diverse LGBT community exists in SC and needs include increased programming for community members as well as efforts to provide policy-level support and increased acceptability and understanding of LGBT persons in South Carolina.

High-harmonic fast-wave power flow along magnetic field lines in the scrape-off layer of NSTX.

PubMed

Perkins, R J; Hosea, J C; Kramer, G J; Ahn, J-W; Bell, R E; Diallo, A; Gerhardt, S; Gray, T K; Green, D L; Jaeger, E F; Jaworski, M A; LeBlanc, B P; McLean, A; Maingi, R; Phillips, C K; Roquemore, L; Ryan, P M; Sabbagh, S; Taylor, G; Wilson, J R

2012-07-27

A significant fraction of high-harmonic fast-wave (HHFW) power applied to NSTX can be lost to the scrape-off layer (SOL) and deposited in bright and hot spirals on the divertor rather than in the core plasma. We show that the HHFW power flows to these spirals along magnetic field lines passing through the SOL in front of the antenna, implying that the HHFW power couples across the entire width of the SOL rather than mostly at the antenna face. This result will help guide future efforts to understand and minimize these edge losses in order to maximize fast-wave heating and current drive.

Consumer Education: Ecological Resource Management. Home & Family Life Curriculum Guide: H.E. Bulletin No. 43.

ERIC Educational Resources Information Center

Washington Office of the State Superintendent of Public Instruction, Olympia.

The future ability of secondary students to interact in a progressively technologically-oriented society is the purpose of this curriculum guide on consumer education. The guide teaches consumer decision-making, resource management, and advocacy/action. The introduction discusses the future of society and technology. Each of three sections…

Computational reproducibility of "Goal relevance and goal conduciveness appraisals lead to differential autonomic reactivity in emotional responding to performance feedback" (Kreibig, Gendolla, & Scherer, 2012): A guide and new evidence.

PubMed

Kreibig, Sylvia D

2017-09-01

The emerging field of the psychophysiology of motivation bears many new findings, but little replication. Using my own data (Kreibig, Gendolla, & Scherer, 2012), I test the reproducibility of this specific study, provide the necessary materials to make the study reproducible, and instantiate proper reproducibility practices that other researchers can use as a road map toward the same goal. In addition, based on re-analyses of the original data, I report new evidence for the motivational effects of emotional responding to performance feedback. Specifically, greater appraisal of goal relevance amplifies the emotional response to events appraised as conducive (i.e., effort mobilization), but not to those appraised as obstructive to a person's goals (i.e., effort withdrawal). I conclude by providing a ten-step road map of best practices to facilitate computational reproducibility for future studies. Copyright © 2017 Elsevier B.V. All rights reserved.

Modernizing the World Health Organization List of Essential Medicines for Preventing and Controlling Cardiovascular Diseases.

PubMed

Kishore, Sandeep P; Blank, Evan; Heller, David J; Patel, Amisha; Peters, Alexander; Price, Matthew; Vidula, Mahesh; Fuster, Valentin; Onuma, Oyere; Huffman, Mark D; Vedanthan, Rajesh

2018-02-06

The World Health Organization (WHO) Model List of Essential Medicines (EML) is a key tool for improving global access to medicines for all conditions, including cardiovascular diseases (CVDs). The WHO EML is used by member states to determine their national essential medicine lists and policies and to guide procurement of medicines in the public sector. Here, we describe our efforts to modernize the EML for global CVD prevention and control. We review the recent history of applications to add, delete, and change indications for CVD medicines, with the aim of aligning the list with contemporary clinical practice guidelines. We have identified 4 issues that affect decisions for the EML and may strengthen future applications: 1) cost and cost-effectiveness; 2) presence in clinical practice guidelines; 3) feedback loops; and 4) community engagement. We share our lessons to stimulate others in the global CVD community to embark on similar efforts. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Dilemmas and controversies within civilian and military organizations in the execution of humanitarian aid in Iraq: a review.

PubMed

Morton, Melinda J; Burnham, Gilbert M

2010-01-01

Civilian humanitarian assistance organizations and military forces are working in a similar direction in many humanitarian operations around the world. However, tensions exist over the role of the military in such operations. The purpose of this article is to review cultural perspectives of civilian and military actors and to discuss recent developments in civil-military humanitarian collaboration in the provision of health services in Iraq for guiding such collaborative efforts in postconflict and other settings in future. Optimal collaborative efforts are most likely to be achieved through the following tenets: defining appropriate roles for military forces at the beginning of humanitarian operations (optimally the provision of transportation, logistical coordination, and security), promoting development of ongoing relationships between civilian and military agencies, establishment of humanitarian aid training programs for Department of Defense personnel, and the need for the military to develop and use quantitative aid impact indicators for assuring quality and effectiveness of humanitarian aid.

The SDO Education and Outreach (E/PO) Program: Changing Perceptions One Program at a Time

NASA Technical Reports Server (NTRS)

Drobnes, E.; Littleton, A.; Pesnell, W. D.; Buhr, S.; Beck, K.; Durscher, R.; Hill, S.; McCaffrey, M.; McKenzie, D. E.; Myers, D.;

COINS: A composites information database system

NASA Technical Reports Server (NTRS)

Siddiqi, Shahid; Vosteen, Louis F.; Edlow, Ralph; Kwa, Teck-Seng

1992-01-01

An automated data abstraction form (ADAF) was developed to collect information on advanced fabrication processes and their related costs. The information will be collected for all components being fabricated as part of the ACT program and include in a COmposites INformation System (COINS) database. The aim of the COINS development effort is to provide future airframe preliminary design and fabrication teams with a tool through which production cost can become a deterministic variable in the design optimization process. The effort was initiated by the Structures Technology Program Office (STPO) of the NASA LaRC to implement the recommendations of a working group comprised of representatives from the commercial airframe companies. The principal working group recommendation was to re-institute collection of composite part fabrication data in a format similar to the DOD/NASA Structural Composites Fabrication Guide. The fabrication information collection form was automated with current user friendly computer technology. This work in progress paper describes the new automated form and features that make the form easy to use by an aircraft structural design-manufacturing team.

Expert judgment on markers to deter inadvertent human intrusion into the Waste Isolation Pilot Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trauth, K.M.; Hora, S.C.; Guzowski, R.V.

1993-11-01

The expert panel identified basic principles to guide current and future marker development efforts: (1) the site must be marked, (2) message(s) must be truthful and informative, (3) multiple components within a marker system, (4) multiple means of communication (e.g., language, pictographs, scientific diagrams), (5) multiple levels of complexity within individual messages on individual marker system elements, (6) use of materials with little recycle value, and (7) international effort to maintain knowledge of the locations and contents of nuclear waste repositories. The efficacy of the markers in deterring inadvertent human intrusion was estimated to decrease with time, with the probabilitymore » function varying with the mode of intrusion (who is intruding and for what purpose) and the level of technological development of the society. The development of a permanent, passive marker system capable of surviving and remaining interpretable for 10,000 years will require further study prior to implementation.« less

Playing the Long Game: Considering the Future of Augmentative and Alternative Communication Research and Service.

PubMed

Reichle, Joe; Drager, Kathryn; Caron, Jessica; Parker-McGowan, Quannah

2016-11-01

This article examines the growth of aided augmentative and alternative communication (AAC) in providing support to children and youth with significant communication needs. Addressing current trends and offering a discussion of needs and probable future advances is framed around five guiding principles initially introduced by Williams, Krezman, and McNaughton. These include: (1) communication is a basic right and the use of AAC, especially at a young age, can help individuals realize their communicative potential; (2) AAC, like traditional communication, requires it to be fluid with the ability to adapt to different environments and needs; (3) AAC must be individualized and appropriate for each user; (4) AAC must support full participation in society across all ages and interests; and (5) individuals who use AAC have the right to be involved in all aspects of research, development, and intervention. In each of these areas current advances, needs, and future predictions are offered and discussed in terms of researchers' and practitioners' efforts to a continued upward trajectory of research and translational service delivery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Guide to enable health charities to increase recruitment to clinical trials on dementia.

PubMed

Chambers, Larry W; Harris, Megan; Lusk, Elizabeth; Benczkowski, Debbie

2017-11-01

The Alzheimer Society embarked on a project to improve ways that the 60 provincial and local Societies in Canada can work with local researchers to support recruitment of volunteers to clinical trials and studies. A Guide to assist these offices was produced to design ethical recruitment of research volunteers within their client populations. Consultations with individuals from provincial and local Societies, as well as researchers and leaders from health-related organizations, were conducted to identify in what ways these organizations are involved in study volunteer recruitment, what is and is not working, and what would be helpful to support future efforts. The Guide prototype used scenarios to illustrate study volunteer recruitment practices as they have been or could be applied in Societies. An implementable version of the Guide was produced with input from multiple internal and external reviewers including subject-matter experts and target users from Societies. Society staff reported that benefits of using the Guide were that it served as a catalyst for conversation and reflection and identified the need for a policy. Also, it enabled Society readiness to respond to requests by persons with dementia and their caregivers wishing to participate in research. A majority (94%) of participating Society staff across Canada agreed that they would increase their capacity to support research recruitment. Charitable organizations that raise funds for research have a role in promoting the recruitment of persons with dementia and their caregivers into clinical trials and studies. The Guide was produced to facilitate organizational change to both create a positive culture regarding research as well as practical solutions that can help organizations achieve this goal.

Energy Efficiency Measures to Incorporate into Remodeling Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liaukus, C.

2014-12-01

Energy improvements in a home are often approached as one concerted effort, beginning with a simple walk-through assessment or more in-depth energy audit and followed by the installation of recommended energy measures. While this approach allows for systems thinking to guide the efforts, comprehensive energy improvements of this nature are undertaken by a relatively small number of U.S. households compared to piecemeal remodeling efforts. In this report, the U.S Department of Energy Building America Retrofit Alliance research team examines the improvement of a home’s energy performance in an opportunistic way by examining what can be done to incorporate energy efficiencymore » measures into general remodeling work and home repair projects. This allows for energy efficiency upgrades to occur at the same time as remodeling proejcts. There are challenges to this approach, not the least of which being that the work will take place over time in potentially many separate projects. The opportunity to improve a home’s energy efficiency at one time expands or contracts with the scope of the remodel. As such, guidance on how to do each piece thoughtfully and with consideration for potential future projects, is critical.« less

Overview of NASA GRC Stirling Technology Development

NASA Technical Reports Server (NTRS)

Schreiber, Jeffrey G.; Thieme, Lanny G.

2004-01-01

The Stirling Radioisotope Generator (SRG) is currently being developed by Lockheed Martin Astronautics (LMA) under contract to the Department of Energy (DOE). The generator will be a high efficiency electric power source for NASA Space Science missions with the ability to operate in vacuum or in an atmosphere such as on Mars. High efficiency is obtained through the use of free-piston Stirling power conversion. Power output will be greater than 100 watts at the beginning of life with the decline in power largely due to the decay of the plutonium heat source. In support of the DOE SRG project, the NASA Glenn Research Center (GRC) has established a technology effort to provide data to ensure a successful transition to flight for what will be the first dynamic power system in space. Initially, a limited number of areas were selected for the effort, however this is now being expanded to more thoroughly cover key technical issues. There is also an advanced technology effort that is complementary to the near-term technology effort. Many of the tests use the 55-We Technology Demonstration Convertor (TDC). There have been multiple controller tests to support the LMA flight controller design effort. Preparation is continuing for a thermal/vacuum system demonstration. A pair of flight prototype TDC s have been placed on continuous operation. Heater head life assessment continues, with the material data being refined and the analysis moving toward the system perspective. Magnet aging tests continue to characterize any possible aging in the strength or demagnetization resistance of the magnets in the linear alternator. A reliability effort has been initiated to help guide the development activities with focus on the key components and subsystems. This paper will provide an overview of some of the GRC technical efforts, including the status, and a description of future efforts.

Structuring Disaster Recovery Infrastructure Decisions: Lessons from Boulder County's 2013 Flood Recovery

NASA Astrophysics Data System (ADS)

Clavin, C.; Petropoulos, Z.

2017-12-01

Recovery phase decision making processes, as compared to mitigation and response phase decision making processes, require communities make significant financial and capital decisions in the months after a disaster. Collectively, these investments may significantly contribute to the resilience of a community to future hazards. Pre-disaster administrative decisions are well-established within existing planning processes. Post-event recovery requires community decision makers to quickly evaluate technical proposals and manage significant recovery financial resources to ensure their community rebuilds in a manner that will be more resilient to future events. These technical and administrative hurdles in the aftermath of a disaster create a challenging atmosphere to make sound, scientifically-informed decisions leading to resilient recovery. In September 2013, a 1,000-year rain event that resulted in flooding throughout the Front Range of Colorado, significantly impacting Boulder County. While the event is long past, disaster recovery efforts still continue in parts of Boulder County. Boulder County officials formed a county collaborative that adapted the NIST Community Resilience Planning Guide for Buildings and Infrastructure Systems to facilitate a goals-based multi-criteria decision making process. Rather than use hazard-based information to guide infrastructure design, the county's decision process established time-to-recovery goals for infrastructure systems that were used as criteria for project design. This presentation explores the decision-making process employed by Boulder County to specify design standards for resilient rebuilding of infrastructure systems and examine how this infrastructure planning model could be extrapolated to other situations where there is uncertainty regarding future infrastructure design standards.

National Women's History Week Curriculum Guide.

ERIC Educational Resources Information Center

Women's Support Network, Inc., Santa Rosa, CA.

Designed for elementary and secondary level use, the ideas, materials, and resources in this guide are intended to facilitate teachers' first efforts at expanding the study of women in U.S. history. The cross-cultural guide provides introductory information and suggestions to help develop classroom observances for the National Women's History Week…

Curriculum Guide for Agriculture.

ERIC Educational Resources Information Center

Oregon State Board of Education, Salem. Div. of Community Colleges and Career Education.

Developed through a cooperative effort by industry and education, this curriculum guide outlines the basic knowledge and skills necessary for entry-level competencies in the broad field of agriculture, or for entrance into a post-high school program. This guide is one of several developed for Oregon's new approach to secondary education called…

Educational Research in China: Guiding Principles and Major Tasks.

ERIC Educational Resources Information Center

Wu, Wei

This account of efforts to reconstruct educational research in China, guided by Marxist principles and reflective of a national policy of building a "socialist spiritual civilization," presents the major requirements of that endeavor. Educational sciences are to be guided by four understandings: correct theories; realistic policies;…

Women's History Curriculum Guide.

ERIC Educational Resources Information Center

Ruthsdotter, Mary, Ed.; Eisenberg, Bonnie, Ed.

This curriculum guide is designed to facilitate teachers' first efforts to introduce information about women in U.S. history. The guide promotes a multicultural awareness of women's history beginning with the Native Americans and proceeding to current issues of diversity. Activities are divided for grades 1-6 and 7-12 but may be adapted as…

Interprofessional Collaboration 1996 Resource Guide: A Resource Guide of Learning Activities.

ERIC Educational Resources Information Center

Hanley, Mary Stone; And Others

The Training for Interprofessional Collaboration Project (TIC) is a joint effort of five professional schools of the University of Washington and various community sites and agencies to provide preservice (graduate level) and inservice training in teacher and interprofessional collaboration. The guide includes bibliographies, case studies,…

Curriculum Guide for Electricity-Electronics.

ERIC Educational Resources Information Center

Oregon State Board of Education, Salem. Div. of Community Colleges and Career Education.

Developed through a cooperative effort by industry and education, this curriculum guide outlines the basic skills and knowledge necessary for entry-level competencies in the broad field of electricity-electronics, or for entrance into an apprenticeship, post-high school, or university program. This guide is one of several developed for Oregon's…

Elementary/Middle School Keyboarding Strategies Guide.

ERIC Educational Resources Information Center

National Business Education Association, Reston, VA.

Developed through a cooperative effort of many teachers and researchers, this guide is intended to supplement existing elementary and middle school materials on keyboarding. The guide contains sections that are designed for stand-alone use. Topics cover a wide range of strategies, including teaching special needs students. The U.S. Postal Service…

A new resource for developing and strengthening large-scale community health worker programs.

PubMed

Perry, Henry; Crigler, Lauren; Lewin, Simon; Glenton, Claire; LeBan, Karen; Hodgins, Steve

2017-01-12

Large-scale community health worker programs are now growing in importance around the world in response to the resurgence of interest and growing evidence of the importance of community-based primary health care for improving the health of populations in resource-constrained, high-mortality settings. These programs, because of their scale and operational challenges, merit special consideration by the global health community, national policy-makers, and program implementers. A new online resource is now available to assist in that effort: Developing and Strengthening Community Health Worker Programs at Scale: A Reference Guide and Case Studies for Program Managers and Policymakers ( http://www.mchip.net/CHWReferenceGuide ). This CHW Reference Guide is the product of 27 different collaborators who, collectively, have a formidable breadth and depth of experience and knowledge about CHW programming around the world. It provides a thoughtful discussion about the many operational issues that large-scale CHW programs need to address as they undergo the process of development, expansion or strengthening. Detailed case studies of 12 national CHW programs are included in the Appendix-the most current and complete cases studies as a group that are currently available. Future articles in this journal will highlight many of the themes in the CHW Reference Guide and provide an update of recent advances and experiences. These articles will serve, we hope, to (1) increase awareness about the CHW Reference Guide and its usefulness and (2) connect a broader audience to the critical importance of strengthening large-scale CHW programs for the health benefits that they can bring to underserved populations around the world.

Scientific American Frontiers Teaching Guides for Shows 701-705, October 1996-April 1997.

ERIC Educational Resources Information Center

Connecticut Public Television, Hartford.

These teaching guides are meant to supplement the seventh season (1996-97) of the PBS Series "Scientific American Frontiers". Episode 701 is entitled "Inventing the Future: A Tour of the MIT Media Lab" and the teaching guide contains information and activities on a virtual pet dog, computers of the future, a smart car designed…

What do Demand-Control and Effort-Reward work stress questionnaires really measure? A discriminant content validity study of relevance and representativeness of measures.

PubMed

Bell, Cheryl; Johnston, Derek; Allan, Julia; Pollard, Beth; Johnston, Marie

2017-05-01

The Demand-Control (DC) and Effort-Reward Imbalance (ERI) models predict health in a work context. Self-report measures of the four key constructs (demand, control, effort, and reward) have been developed and it is important that these measures have good content validity uncontaminated by content from other constructs. We assessed relevance (whether items reflect the constructs) and representativeness (whether all aspects of the construct are assessed, and all items contribute to that assessment) across the instruments and items. Two studies examined fourteen demand/control items from the Job Content Questionnaire and seventeen effort/reward items from the Effort-Reward Imbalance measure using discriminant content validation and a third study developed new methods to assess instrument representativeness. Both methods use judges' ratings and construct definitions to get transparent quantitative estimates of construct validity. Study 1 used dictionary definitions while studies 2 and 3 used published phrases to define constructs. Overall, 3/5 demand items, 4/9 control items, 1/6 effort items, and 7/11 reward items were uniquely classified to the appropriate theoretical construct and were therefore 'pure' items with discriminant content validity (DCV). All pure items measured a defining phrase. However, both the DC and ERI assessment instruments failed to assess all defining aspects. Finding good discriminant content validity for demand and reward measures means these measures are usable and our quantitative results can guide item selection. By contrast, effort and control measures had limitations (in relevance and representativeness) presenting a challenge to the implementation of the theories. Statement of contribution What is already known on this subject? While the reliability and construct validity of Demand-Control and Effort-Reward-Imbalance (DC and ERI) work stress measures are routinely reported, there has not been adequate investigation of their content validity. This paper investigates their content validity in terms of both relevance and representativeness and provides a model for the investigation of content validity of measures in health psychology more generally. What does this study add? A new application of an existing method, discriminant content validity, and a new method of assessing instrument representativeness. 'Pure' DC and ERI items are identified, as are constructs that are not fully represented by their assessment instruments. The findings are important for studies attempting to distinguish between the main DC and ERI work stress constructs. The quantitative results can be used to guide item selection for future studies. © 2017 The British Psychological Society.

A Guide to Disability Statistics from the Behavioral Risk Factors Surveillance System. Disability Statistics User Guide Series

ERIC Educational Resources Information Center

Erickson, William A.; Dumoulin-Smith, Adrien

2009-01-01

The mission of the Cornell StatsRRTC is to bridge the divide between the sources of disability data and the users of disability statistics. One product of this effort is a set of "User Guides" to national survey data that collect information on the disability population. The purpose of each of the "User Guides" is to provide…

Modeling and Evaluating Pilot Performance in NextGen: Review of and Recommendations Regarding Pilot Modeling Efforts, Architectures, and Validation Studies

NASA Technical Reports Server (NTRS)

Wickens, Christopher; Sebok, Angelia; Keller, John; Peters, Steve; Small, Ronald; Hutchins, Shaun; Algarin, Liana; Gore, Brian Francis; Hooey, Becky Lee; Foyle, David C.

2013-01-01

NextGen operations are associated with a variety of changes to the national airspace system (NAS) including changes to the allocation of roles and responsibilities among operators and automation, the use of new technologies and automation, additional information presented on the flight deck, and the entire concept of operations (ConOps). In the transition to NextGen airspace, aviation and air operations designers need to consider the implications of design or system changes on human performance and the potential for error. To ensure continued safety of the NAS, it will be necessary for researchers to evaluate design concepts and potential NextGen scenarios well before implementation. One approach for such evaluations is through human performance modeling. Human performance models (HPMs) provide effective tools for predicting and evaluating operator performance in systems. HPMs offer significant advantages over empirical, human-in-the-loop testing in that (1) they allow detailed analyses of systems that have not yet been built, (2) they offer great flexibility for extensive data collection, (3) they do not require experimental participants, and thus can offer cost and time savings. HPMs differ in their ability to predict performance and safety with NextGen procedures, equipment and ConOps. Models also vary in terms of how they approach human performance (e.g., some focus on cognitive processing, others focus on discrete tasks performed by a human, while others consider perceptual processes), and in terms of their associated validation efforts. The objectives of this research effort were to support the Federal Aviation Administration (FAA) in identifying HPMs that are appropriate for predicting pilot performance in NextGen operations, to provide guidance on how to evaluate the quality of different models, and to identify gaps in pilot performance modeling research, that could guide future research opportunities. This research effort is intended to help the FAA evaluate pilot modeling efforts and select the appropriate tools for future modeling efforts to predict pilot performance in NextGen operations.

Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats

PubMed Central

Ostrander, Serena; Cazares, Victor A.; Kim, Charissa; Cheung, Shauna; Gonzalez, Isabel; Izquierdo, Alicia

2011-01-01

The orbitofrontal cortex (OFC) and basolateral nucleus of the amygdala (BLA) are important neural regions in responding adaptively to changes in the incentive value of reward. Recent evidence suggests these structures may be differentially engaged in effort and cue-guided choice behavior. In two t-maze experiments, we examined the effects of bilateral lesions of either BLA or OFC on 1) effortful choices where rats could climb a barrier for a high reward or select a low reward with no effort and 2) effortful choices when a visual cue signaled changes in reward magnitude. In both experiments, BLA rats displayed transient work aversion, choosing the effortless low reward option. OFC rats were work averse only in the no cue conditions, displaying a pattern of attenuated recovery from the cue conditions signaling reward unavailability in the effortful arm. Control measures rule out an inability to discriminate the cue in either lesion group. PMID:21639604

The Annie E. Casey Foundation's New Futures Initiative: Strategic Planning Guide. (Revised).

ERIC Educational Resources Information Center

Center for the Study of Social Policy, Washington, DC.

Information in this guide is based on published research concerning effective strategies in dealing with at-risk youth. It was written for those communities invited to develop proposals under the Annie E. Casey Foundation's New Futures Initiative in an attempt to alleviate problems that compromise American children's futures. Each of three…

The Students' Guide to Lobbying. Second Edition.

ERIC Educational Resources Information Center

Beaton, Karen; Scattergood, Phyllis, Ed.

Lobbying is defined as the function of citizens to express their views and to gain the support of legislators for proposed laws. This guide, for Massachusetts students, is designed to take students step by step through the lobbying process and to suggest strategies and resources to use in their own lobbying efforts. The guide contains the…

A Guide to Drug Abuse Education and Information Materials, 1972.

ERIC Educational Resources Information Center

National Inst. of Mental Health (DHEW), Rockville, MD.

This guide was developed from efforts initiated by the National Institute of Mental Health (NIMH) to inform and educate the public about drug abuse beginning in April, 1969. At that time, NIMH produced television spots, radio announcements, newspaper and magazine ads, films, and general awareness publications. This guide was developed to make…

Literacy Outreach: The Community Link. A Guide to Working with Literacy Helpers.

ERIC Educational Resources Information Center

Green, Karen Reed; And Others

This guide, which is addressed to community-based organizations desiring to start or expand existing adult literacy programs, deals with recruiting and training volunteer literacy tutors. Outlined in the guide are strategies for expanding community outreach efforts (identifying who needs help and where help is typically obtained, learning from…

Planning for Worker Re-Adjustment: A Technical Assistance Guide for States.

ERIC Educational Resources Information Center

Balfe, Kevin

This guide summarizes key principles drawn from successful programs for helping unemployed workers find new jobs and presents a systematic approach to help states plan and manage their worker readjustment efforts. The guide contains two major sections. The first section is an overview and summary that includes background on the dislocation…

Teacher-Coordinator's Guide for Related Instruction in Multi-Occupation Cooperative Programs.

ERIC Educational Resources Information Center

Spooner, Kendrick, Ed.; Mutter, Marylouise, Ed.

The product of two teacher-coordinator workshops, the guide represents the cooperative efforts of the teacher participants and provides supplementary instructional materials for secondary school multioccupational cooperative programs. The first section of the guide is intended for use in large group classroom instruction and deals with the goals,…

A vulnerability tool for adapting water and aquatic resources to climate change and extremes on the Shoshone National Forest, Wyoming

NASA Astrophysics Data System (ADS)

Rice, J.; Joyce, L. A.; Armel, B.; Bevenger, G.; Zubic, R.

2011-12-01

Climate change introduces a significant challenge for land managers and decision makers managing the natural resources that provide many benefits from forests. These benefits include water for urban and agricultural uses, wildlife habitat, erosion and climate control, aquifer recharge, stream flows regulation, water temperature regulation, and cultural services such as outdoor recreation and aesthetic enjoyment. The Forest Service has responded to this challenge by developing a national strategy for responding to climate change (the National Roadmap for Responding to Climate Change, July 2010). In concert with this national strategy, the Forest Service's Westwide Climate Initiative has conducted 4 case studies on individual Forests in the western U.S to develop climate adaptation tools. Western National Forests are particularly vulnerable to climate change as they have high-mountain topography, diversity in climate and vegetation, large areas of water limited ecosystems, and increasing urbanization. Information about the vulnerability and capacity of resources to adapt to climate change and extremes is lacking. There is an urgent need to provide customized tools and synthesized local scale information about the impacts to resources from future climate change and extremes, as well as develop science based adaptation options and strategies in National Forest management and planning. The case study on the Shoshone National Forest has aligned its objectives with management needs by developing a climate extreme vulnerability tool that guides adaptation options development. The vulnerability tool determines the likely degree to which native Yellowstone cutthroat trout and water availability are susceptible to, or unable to cope with adverse effects of climate change extremes. We spatially categorize vulnerability for water and native trout resources using exposure, sensitivity, and adaptive capacity indicators that use minimum and maximum climate and GIS data. Results show that the vulnerability of water availability may increase in areas that have less storage and become more dominated by rain instead of snow. Native trout habitat was found to improve in some areas from warmer temperatures suggesting future refugia habitat may need to be a focus of conservation efforts. The climate extreme vulnerability tool provides Forest Service resource managers science based information that guides adaptation strategy development; prioritize conservation projects; guides monitoring efforts, and helps promote more resilient ecosystems undergoing the effects of climate change.

Programming Equity into Computer Education: Today's Guide to the Schools of the Future. A PEER Computer Equity Action Kit.

ERIC Educational Resources Information Center

Martin-McCormick, Lynda; And Others

An advocacy packet on educational equity in computer education consists of five separate materials. A booklet entitled "Today's Guide to the Schools of the Future" contains four sections. The first section, a computer equity assessment guide, includes interview questions about school policies and allocation of resources, student and teacher…

Southeast Atmosphere Studies: learning from model-observation syntheses

NASA Astrophysics Data System (ADS)

Mao, Jingqiu; Carlton, Annmarie; Cohen, Ronald C.; Brune, William H.; Brown, Steven S.; Wolfe, Glenn M.; Jimenez, Jose L.; Pye, Havala O. T.; Ng, Nga Lee; Xu, Lu; McNeill, V. Faye; Tsigaridis, Kostas; McDonald, Brian C.; Warneke, Carsten; Guenther, Alex; Alvarado, Matthew J.; de Gouw, Joost; Mickley, Loretta J.; Leibensperger, Eric M.; Mathur, Rohit; Nolte, Christopher G.; Portmann, Robert W.; Unger, Nadine; Tosca, Mika; Horowitz, Larry W.

2018-02-01

Concentrations of atmospheric trace species in the United States have changed dramatically over the past several decades in response to pollution control strategies, shifts in domestic energy policy and economics, and economic development (and resulting emission changes) elsewhere in the world. Reliable projections of the future atmosphere require models to not only accurately describe current atmospheric concentrations, but to do so by representing chemical, physical and biological processes with conceptual and quantitative fidelity. Only through incorporation of the processes controlling emissions and chemical mechanisms that represent the key transformations among reactive molecules can models reliably project the impacts of future policy, energy and climate scenarios. Efforts to properly identify and implement the fundamental and controlling mechanisms in atmospheric models benefit from intensive observation periods, during which collocated measurements of diverse, speciated chemicals in both the gas and condensed phases are obtained. The Southeast Atmosphere Studies (SAS, including SENEX, SOAS, NOMADSS and SEAC4RS) conducted during the summer of 2013 provided an unprecedented opportunity for the atmospheric modeling community to come together to evaluate, diagnose and improve the representation of fundamental climate and air quality processes in models of varying temporal and spatial scales.This paper is aimed at discussing progress in evaluating, diagnosing and improving air quality and climate modeling using comparisons to SAS observations as a guide to thinking about improvements to mechanisms and parameterizations in models. The effort focused primarily on model representation of fundamental atmospheric processes that are essential to the formation of ozone, secondary organic aerosol (SOA) and other trace species in the troposphere, with the ultimate goal of understanding the radiative impacts of these species in the southeast and elsewhere. Here we address questions surrounding four key themes: gas-phase chemistry, aerosol chemistry, regional climate and chemistry interactions, and natural and anthropogenic emissions. We expect this review to serve as a guidance for future modeling efforts.

Southeast Atmosphere Studies: learning from model-observation syntheses

PubMed Central

Mao, Jingqiu; Carlton, Annmarie; Cohen, Ronald C.; Brune, William H.; Brown, Steven S.; Wolfe, Glenn M.; Jimenez, Jose L.; Pye, Havala O. T.; Ng, Nga Lee; Xu, Lu; McNeill, V. Faye; Tsigaridis, Kostas; McDonald, Brian C.; Warneke, Carsten; Guenther, Alex; Alvarado, Matthew J.; de Gouw, Joost; Mickley, Loretta J.; Leibensperger, Eric M.; Mathur, Rohit; Nolte, Christopher G.; Portmann, Robert W.; Unger, Nadine; Tosca, Mika; Horowitz, Larry W.

2018-01-01

Concentrations of atmospheric trace species in the United States have changed dramatically over the past several decades in response to pollution control strategies, shifts in domestic energy policy and economics, and economic development (and resulting emission changes) elsewhere in the world. Reliable projections of the future atmosphere require models to not only accurately describe current atmospheric concentrations, but to do so by representing chemical, physical and biological processes with conceptual and quantitative fidelity. Only through incorporation of the processes controlling emissions and chemical mechanisms that represent the key transformations among reactive molecules can models reliably project the impacts of future policy, energy and climate scenarios. Efforts to properly identify and implement the fundamental and controlling mechanisms in atmospheric models benefit from intensive observation periods, during which collocated measurements of diverse, speciated chemicals in both the gas and condensed phases are obtained. The Southeast Atmosphere Studies (SAS, including SENEX, SOAS, NOMADSS and SEAC4RS) conducted during the summer of 2013 provided an unprecedented opportunity for the atmospheric modeling community to come together to evaluate, diagnose and improve the representation of fundamental climate and air quality processes in models of varying temporal and spatial scales. This paper is aimed at discussing progress in evaluating, diagnosing and improving air quality and climate modeling using comparisons to SAS observations as a guide to thinking about improvements to mechanisms and parameterizations in models. The effort focused primarily on model representation of fundamental atmospheric processes that are essential to the formation of ozone, secondary organic aerosol (SOA) and other trace species in the troposphere, with the ultimate goal of understanding the radiative impacts of these species in the southeast and elsewhere. Here we address questions surrounding four key themes: gas-phase chemistry, aerosol chemistry, regional climate and chemistry interactions, and natural and anthropogenic emissions. We expect this review to serve as a guidance for future modeling efforts.

Southeast Atmosphere Studies: Learning from Model-Observation Syntheses

NASA Technical Reports Server (NTRS)

Mao, Jingqiu; Carlton, Annmarie; Cohen, Ronald C.; Brune, William H.; Brown, Steven S.; Wolfe, Glenn M.; Jimenez, Jose L.; Pye, Havala O. T.; Ng, Nga Lee; Xu, Lu;

Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.

PubMed

Rosenbaum, Brooke E; Klein, Rebecca; Hagan, Paa Gyasi; Seadey, Mark-Young; Quarcoo, Naa Larteley; Hoffmann, Rachel; Robinson, Maria; Lartey, Margaret; Leger, Marie C

2017-01-01

Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. We conducted a chart review of new patients presenting to the Korle Bu Teaching Hospital dermatology clinic during 2014. Among the 529 patients studied, 700 discrete diagnoses were made. The most commonly diagnosed skin conditions were infections (24.6%) and dermatitis (24.6%); atopic dermatitis (8.4%), acne vulgaris (5.3%) and scabies (5.1%) were the most common specific diagnoses. Among infants, children, and adolescents, the most common diagnosis was atopic dermatitis (31.7%, 30.0%, and 14.9%, respectively). Acne vulgaris (12.0%) was the most common skin condition diagnosed in young adults. Irritant contact dermatitis (6.9%) was most common among adults. Lichen planus (9.9%) was the most commonly diagnosed skin condition in the senior population. Diagnoses made by dermatologists differed from the referral diagnosis documented by primary care providers for 65.8% of patients. The most frequently recommended treatments were antihistamines (47.8%) and topical steroids (38.4%). Only 18 diagnostic biopsies were performed. Our study summarizes the skin diseases seen and management practices of Ghanaian dermatologists in a specialized clinic at a large public teaching hospital. The results of this study can help to guide future dermatology education and development efforts in Ghana.

The Department of Defense at the Forefront of a Global Health Emergency Response: Lessons Learned from the Ebola Outbreak.

PubMed

Diehl, Glendon; Bradstreet, Nicole; Monahan, Felicia

2016-01-01

Tasked with analyzing the effectiveness of the Department of Defense's (DoD's) global health engagements, the Uniformed Services University of the Health Sciences (USU) used the Measures Of Effectiveness in Defense Engagement and Learning (MODEL) study to conduct a qualitative analysis of the DoD's response efforts to the Ebola pandemic in West Africa. The research aims to summarize the findings of studies that monitor and evaluate the DoD's response to the Ebola pandemic or compare the effectiveness of different DoD response activities; it further aims to identify common themes around positive and negative lessons learned and recommendations that can be applied to future DoD humanitarian assistance and disaster response efforts. The search included documents and observations from PubMed, Disaster Lit: Resource Guide for Disaster Medicine and Public Health, the Joint Lessons Learned Information System, the DoD and US Africa Command websites, and Google Scholar. The records selected from the search were analyzed to provide insights on the DoD's humanitarian assistance and disaster response engagements that could be employed to inform future operations and policy. Furthermore, the research identifies strengths and gaps in military capabilities to respond to disasters, which can be used to inform future training and education courses. Overall, the findings demonstrate the importance of monitoring, evaluating, and assessing disaster response activities and provide new evidence to support the implementation of activities, in accordance with the Global Health Security Agenda, to strengthen all-threat prevention, detection, and response capabilities worldwide.

Accuracy of Binary Black Hole Waveform Models for Advanced LIGO

NASA Astrophysics Data System (ADS)

Kumar, Prayush; Fong, Heather; Barkett, Kevin; Bhagwat, Swetha; Afshari, Nousha; Chu, Tony; Brown, Duncan; Lovelace, Geoffrey; Pfeiffer, Harald; Scheel, Mark; Szilagyi, Bela; Simulating Extreme Spacetimes (SXS) Team

2016-03-01

Coalescing binaries of compact objects, such as black holes and neutron stars, are the primary targets for gravitational-wave (GW) detection with Advanced LIGO. Accurate modeling of the emitted GWs is required to extract information about the binary source. The most accurate solution to the general relativistic two-body problem is available in numerical relativity (NR), which is however limited in application due to computational cost. Current searches use semi-analytic models that are based in post-Newtonian (PN) theory and calibrated to NR. In this talk, I will present comparisons between contemporary models and high-accuracy numerical simulations performed using the Spectral Einstein Code (SpEC), focusing at the questions: (i) How well do models capture binary's late-inspiral where they lack a-priori accurate information from PN or NR, and (ii) How accurately do they model binaries with parameters outside their range of calibration. These results guide the choice of templates for future GW searches, and motivate future modeling efforts.

Improving Support for America's Hidden Heroes

PubMed Central

Terri, Tanielian; Kathryn E., Bouskill; Rajeev, Ramchand; Esther M., Friedman; Thomas E., Trail; Angela, Clague

2018-01-01

Abstract The United States is home to more than 21 million veterans, many of whom deployed to support combat operations around the globe during their military service and sustained service-related conditions or disabilities. Supporting these wounded, ill, and injured warriors once home are millions of informal caregivers—individuals who provide unpaid support with activities that enable the service member or veteran to live in a noninstitutionalized setting. In this study, researchers describe elements of a research blueprint to inform future efforts to improve support for military and veteran caregivers. To construct this blueprint, researchers inventoried currently available research on caregiving for disabled adults and children and gathered stakeholder input by conducting a survey and facilitating an online panel. The study highlights the need for more studies that examine how military and veteran caregiver needs evolve over time, how programs are working, and how caregiving affects specific subgroups. The resulting blueprint should serve as a guide for the caregiver support community to use in prioritizing and facilitating future research. PMID:29416949

Enhancing Human Responses to Climate Change Risks through Simulated Flooding Experiences

NASA Astrophysics Data System (ADS)

Zaalberg, Ruud; Midden, Cees

Delta areas are threatened by global climate change. The general aims of our research were (1) to increase our understanding of climate and flood risk perceptions and the factors that influence these judgments, and (2) to seek for interventions that can contribute to a realistic assessment by laypersons of long-term flooding risks. We argue that awareness of one's own vulnerability to future flooding and insights into the effectiveness of coping strategies is driven by direct flooding experiences. In the current research multimodal sensory stimulation by means of interactive 3D technology is used to simulate direct flooding experiences at the experiential or sensory level, thereby going beyond traditional persuasion attempts using fear-evoking images. Our results suggest that future communication efforts should not only use these new technologies to transfer knowledge about effective coping strategies and flooding risks, but should especially be directed towards residents living in flood prone areas, but who lack direct flooding experiences as their guiding principle.

Improving Support for America's Hidden Heroes: A Research Blueprint.

PubMed

Terri, Tanielian; Kathryn E, Bouskill; Rajeev, Ramchand; Esther M, Friedman; Thomas E, Trail; Angela, Clague

2018-01-01

The United States is home to more than 21 million veterans, many of whom deployed to support combat operations around the globe during their military service and sustained service-related conditions or disabilities. Supporting these wounded, ill, and injured warriors once home are millions of informal caregivers-individuals who provide unpaid support with activities that enable the service member or veteran to live in a noninstitutionalized setting. In this study, researchers describe elements of a research blueprint to inform future efforts to improve support for military and veteran caregivers. To construct this blueprint, researchers inventoried currently available research on caregiving for disabled adults and children and gathered stakeholder input by conducting a survey and facilitating an online panel. The study highlights the need for more studies that examine how military and veteran caregiver needs evolve over time, how programs are working, and how caregiving affects specific subgroups. The resulting blueprint should serve as a guide for the caregiver support community to use in prioritizing and facilitating future research.

Mesolimbic Dopamine Signals the Value of Work

PubMed Central

Hamid, Arif A.; Pettibone, Jeffrey R.; Mabrouk, Omar S.; Hetrick, Vaughn L.; Schmidt, Robert; Vander Weele, Caitlin M.; Kennedy, Robert T.; Aragona, Brandon J.; Berke, Joshua D.

2015-01-01

Dopamine cell firing can encode errors in reward prediction, providing a learning signal to guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating current behavior. Existing theories propose that fast (“phasic”) dopamine fluctuations support learning, while much slower (“tonic”) dopamine changes are involved in motivation. We examined dopamine release in the nucleus accumbens across multiple time scales, using complementary microdialysis and voltammetric methods during adaptive decision-making. We first show that minute-by-minute dopamine levels covary with reward rate and motivational vigor. We then show that second-by-second dopamine release encodes an estimate of temporally-discounted future reward (a value function). We demonstrate that changing dopamine immediately alters willingness to work, and reinforces preceding action choices by encoding temporal-difference reward prediction errors. Our results indicate that dopamine conveys a single, rapidly-evolving decision variable, the available reward for investment of effort, that is employed for both learning and motivational functions. PMID:26595651

Genetic diversity and genetic structure of an endemic Mexican Dusky Rattlesnake (Crotalus triseriatus) in a highly modified agricultural landscape: implications for conservation.

PubMed

Sunny, Armando; Monroy-Vilchis, Octavio; Zarco-González, Martha M; Mendoza-Martínez, Germán David; Martínez-Gómez, Daniel

2015-12-01

It is necessary to determine genetic diversity of fragmented populations in highly modified landscapes to understand how populations respond to land-use change. This information will help guide future conservation and management strategies. We conducted a population genetic study on an endemic Mexican Dusky Rattlesnake (Crotalus triseriatus) in a highly modified landscape near the Toluca metropolitan area, in order to provide crucial information for the conservation of this species. There was medium levels of genetic diversity, with a few alleles and genotypes. We identified three genetically differentiated clusters, likely as a result of different habitat cover type. We also found evidence of an ancestral genetic bottleneck and medium values of effective population size. Inbreeding coefficients were low and there was a moderate gene flow. Our results can be used as a basis for future research and C. triseriatus conservation efforts, particularly considering that the Trans-Mexican Volcanic Belt is heavily impacted by destructive land-use practices.

Dinosaurs and Power Plants. Energy from the Past for the Future. Teacher's Lesson Plan and Activity Guide; Teacher's Guide Supplement of Reproducible Graphics.

ERIC Educational Resources Information Center

Department of Energy, Washington, DC. Office of Fossil Energy.

This teacher's guide and its accompanying supplement were prepared for use with the U.S. Department of Energy's Dinosaurs and Power Plants, a publication designed for students in grades 5-8 about the history, detection, extraction, transportation, use, environmental problem/solutions, and future of fossil energy. The study of energy science shows…

Project Overview: A Reef Manager's Guide to Coral Bleaching ...

EPA Pesticide Factsheets

The purpose of this report is to provide the latest scientific knowledge and discuss available management options to assist local and regional managers in responding effectively to mass coral bleaching events. Background A Reef Manager’s Guide to Coral Bleaching is the result of a collaborative effort by over 50 scientists and managers to: (1) share the best available scientific information on climate-related coral bleaching; and (2) compile a tool kit of currently available strategies for adaptive management of coral reefs in a changing climate. The result is a compendium of current information, tools, and practical suggestions to aid managers in their efforts to protect reefs in a way that maximizes reef resilience in the face of continuing climate change. The Guide is a joint publication of the National Oceanic and Atmospheric Administration, the Great Barrier Reef Marine Park Authority, and The World Conservation Union, with author contributions from a variety of international partners from government agencies, non-governmental organizations, and academic institutions. EPA’s Office of Research and Development was a major contributor to the Guide through authorship and participation in the final review and editing process for the entire report. A Reef Manager’s Guide to Coral Bleaching is the result of a collaborative effort by over 50 scientists and managers to: (1) share the best available scientific information on climate-related coral blea

Guided goal setting: effectiveness in a dietary and physical activity intervention with low-income adolescents.

PubMed

Shilts, Mical Kay; Horowitz, Marcel; Townsend, Marilyn S

2009-01-01

Determining the effectiveness of the guided goal setting strategy on changing adolescents' dietary and physical activity self-efficacy and behaviors. Adolescents were individually assigned to treatment (intervention with guided goal setting) or control conditions (intervention without guided goal setting) with data collected before and after the education intervention. Urban middle school in a low-income community in Central California. Ethnically diverse middle school students (n = 94, 55% male) who were participants of a USDA nutrition education program. Driven by the Social Cognitive Theory, the intervention targeted dietary and physical activity behaviors of adolescents. Dietary self-efficacy and behavior; physical activity self-efficacy and behavior; goal effort and spontaneous goal setting. ANCOVA and path analysis were performed using the full sample and a sub-sample informed by Locke's recommendations (accounting for goal effort and spontaneous goal setting). No significant differences were found between groups using the full sample. Using the sub-sample, greater gains in dietary behavior (p < .05), physical activity behavior (p < .05), and physical activity self-efficacy (p < .05) were made by treatment participants compared to control participants. Change in physical activity behaviors was mediated by self-efficacy. Accounting for goal effort and spontaneous goal setting, this study provides some evidence that the use of guided goal setting with adolescents may be a viable strategy to promote dietary and physical activity behavior change.

STS-88 Mission Insignia

NASA Technical Reports Server (NTRS)

1998-01-01

Designed by the STS-88 crew members, this patch commemorates the first assembly flight to carry United States-built hardware for constructing the International Space Station (ISS). This flight's primary task was to assemble the cornerstone of the Space Station: the Node with the Functional Cargo Block (FGB). The rising sun symbolizes the dawning of a new era of international cooperation in space and the beginning of a new program: the International Space Station. The Earth scene outlines the countries of the Station Partners: the United States, Russia, those of the European Space Agency (ESA), Japan, and Canada. Along with the Pressurized Mating Adapters (PMA) and the Functional Cargo Block, the Node is shown in the final mated configuration while berthed to the Space Shuttle during the STS-88/2A mission. The Big Dipper Constellation points the way to the North Star, a guiding light for pioneers and explorers for generations. In the words of the crew, These stars symbolize the efforts of everyone, including all the countries involved in the design and construction of the International Space Station, guiding us into the future.

Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.

PubMed

Dao, Kim-Hien T; Tyner, Jeffrey W; Gotlib, Jason

2017-10-01

We reviewed recent diagnostic and therapeutic progress in chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). We summarized recent genetic data that may guide future efforts towards implementing risk-adapted therapy based on mutational profile and improving disease control and survival of affected patients. Recent genetic data in CNL and aCML prompted modifications to the World Health Organization (WHO) diagnostic criteria, which have improved our understanding of how CNL and aCML are different diseases despite sharing common findings of peripheral granulocytosis and marrow myeloid hyperplasia. The overlap of recurrently mutated genes between aCML and CMML support considering CSF3R-T618I mutated cases as a distinct entity, either as CNL or CNL with dysplasia. Ongoing preclinical and clinical studies will help to further inform the therapeutic approach to these diseases. Our understanding of CNL and aCML has greatly advanced over the last few years. This will improve clarity for the diagnosis of these diseases, provide a strategy for risk stratification, and guide risk-adapted therapy.

Similarity Rules for Scaling Solar Sail Systems

NASA Technical Reports Server (NTRS)

Canfield, Stephen L.; Beard, James W., III; Peddieson, John; Ewing, Anthony; Garbe, Greg

2004-01-01

Future science missions will require solar sails on the order 10,000 sq m (or larger). However, ground and flight demonstrations must be conducted at significantly smaller Sizes (400 sq m for ground demo) due to limitations of ground-based facilities and cost and availability of flight opportunities. For this reason, the ability to understand the process of scalability, as it applies to solar sail system models and test data, is crucial to the advancement of this technology. This report will address issues of scaling in solar sail systems, focusing on structural characteristics, by developing a set of similarity or similitude functions that will guide the scaling process. The primary goal of these similarity functions (process invariants) that collectively form a set of scaling rules or guidelines is to establish valid relationships between models and experiments that are performed at different orders of scale. In the near term, such an effort will help guide the size and properties of a flight validation sail that will need to be flown to accurately represent a large, mission-level sail.

International Space Station (ISS)

NASA Image and Video Library

1998-11-08

Designed by the STS-88 crew members, this patch commemorates the first assembly flight to carry United States-built hardware for constructing the International Space Station (ISS). This flight's primary task was to assemble the cornerstone of the Space Station: the Node with the Functional Cargo Block (FGB). The rising sun symbolizes the dawning of a new era of international cooperation in space and the beginning of a new program: the International Space Station. The Earth scene outlines the countries of the Station Partners: the United States, Russia, those of the European Space Agency (ESA), Japan, and Canada. Along with the Pressurized Mating Adapters (PMA) and the Functional Cargo Block, the Node is shown in the final mated configuration while berthed to the Space Shuttle during the STS-88/2A mission. The Big Dipper Constellation points the way to the North Star, a guiding light for pioneers and explorers for generations. In the words of the crew, These stars symbolize the efforts of everyone, including all the countries involved in the design and construction of the International Space Station, guiding us into the future.

Nanotopography-guided tissue engineering and regenerative medicine☆

PubMed Central

Kim, Hong Nam; Jiao, Alex; Hwang, Nathaniel S.; Kim, Min Sung; Kang, Do Hyun; Kim, Deok-Ho; Suh, Kahp-Yang

2017-01-01

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-defined structures of the extracellular matrix (ECM). The organization of ECM is frequently hierarchical from nano to macro, with many proteins forming large scale structures with feature sizes up to several hundred microns. Inspired from these natural designs of ECM, nanotopography-guided approaches have been increasingly investigated for the last several decades. Results demonstrate that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation. In this review, we provide an extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues. We first characterize the role of various nanostructures in human tissues with respect to each tissue-specific function. Then, we describe various fabrication methods in terms of patterning principles and material characteristics. Finally, we summarize the applications of nanotopography to various tissues, which are classified into four types depending on their functions: protective, mechano-sensitive, electro-active, and shear stress-sensitive tissues. Some limitations and future challenges are briefly discussed at the end. PMID:22921841

Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary

PubMed Central

Wang, J; Johnson, T; Sahin, L; Tassinari, MS; Anderson, PO; Baker, TE; Bucci-Rechtweg, C; Burckart, GJ; Chambers, CD; Hale, TW; Johnson-Lyles, D; Nelson, RM; Nguyen, C; Pica-Branco, D; Ren, Z; Sachs, H; Sauberan, J; Zajicek, A; Ito, S; Yao, LP

2017-01-01

This report serves as a summary of a 2-day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum to discuss the collection of data to inform the potential risks to breastfed infants with maternal use of medications during lactation. Discussions included the review of current approaches to collect data on medications used during lactation, and the considerations for future approaches to design and guide clinical lactation studies. This workshop is part of continuing efforts to raise the awareness of the public for women who choose to breastfeed their infants. PMID:28510297

Image-guided urologic surgery: intraoperative optical imaging and tissue interrogation (Conference Presentation)

NASA Astrophysics Data System (ADS)

Liao, Joseph C.

2017-02-01

Emerging optical imaging technologies can be integrated in the operating room environment during minimally invasive and open urologic surgery, including oncologic surgery of the bladder, prostate, and kidney. These technologies include macroscopic fluorescence imaging that provides contrast enhancement between normal and diseased tissue and microscopic imaging that provides tissue characterization. Optical imaging technologies that have reached the clinical arena in urologic surgery are reviewed, including photodynamic diagnosis, near infrared fluorescence imaging, optical coherence tomography, and confocal laser endomicroscopy. Molecular imaging represents an exciting future arena in conjugating cancer-specific contrast agents to fluorophores to improve the specificity of disease detection. Ongoing efforts are underway to translate optimal targeting agents and imaging modalities, with the goal to improve cancer-specific and functional outcomes.

The effects of bariatric surgery: will understanding its mechanism render the knife unnecessary?

PubMed

Browning, Kirsteen N; Hajnal, Andras

2014-01-01

The incidence of obesity is increasing worldwide at a dramatic rate, accompanied by an associated increase in comorbid conditions. Bariatric surgery is the most effective treatment for morbid obesity with Roux-en-Y gastric bypass being the most commonly performed procedure, yet the underlying mechanisms by which it induces a wide-array of beneficial effects remains obscure. From basic science as well as clinical standpoints, there are several areas of current interest that warrant continued investigation. Several major focus areas have also emerged in current research that may guide future efforts in this field, particularly with regards to using novel, non-surgical approaches to mimic the success of bariatric surgery while minimizing its adverse side effects.

Biophysics of olfaction

NASA Astrophysics Data System (ADS)

Marques Simoes de Souza, Fabio; Antunes, Gabriela

2007-03-01

The majority of the biophysical models of olfaction have been focused on the electrical properties of the system, which is justified by the relative facility of recording the electrical activity of the olfactory cells. However, depending on the level of detail utilized, a biophysical model can explore molecular, cellular and network phenomena. This review presents the state of the art of the biophysical approach to understanding olfaction. The reader is introduced to the principal problems involving the study of olfaction and guided gradually to comprehend why it is important to develop biophysical models to investigate olfaction. A large number of representative biophysical efforts in olfaction, their main contributions, the trends for the next generations of biophysical models and the improvements that may be explored by future biophysicists of olfaction have been reviewed.

NSF/ESF Workshop on Smart Structures and Advanced Sensors, Santorini Island, Greece, June 26-28, 2005: Structural Actuation and Adaptation Working Group

NASA Technical Reports Server (NTRS)

Figueroa, Fernando; Tomizuka, Masayoshi; Bergman, Lawrence; Carpenter, Bernie; Salzano, Carmine; Bairrao, rogerio; Deraemaker, Arnaud; Magonette, Georges; Rodellar, Jose; Kadirkamanathan, Visaken

2005-01-01

This document is a result of discussions that took place during the workshop. It describes current state of research and development (R&D) in the areas of structural actuation and adaptation in the context of smart structures and advanced sensors (SS&AS), and provides an outlook to guide future R&D efforts to develop technologies needed to build SS&AS. The discussions took place among the members of the Structural Actuation and Adaptation Working Group, as well as in general sessions including all four working groups. Participants included members of academia, industry, and government from the US and Europe, and representatives from China, Japan, and Korea.

Work readiness tools for young adults with chronic conditions.

PubMed

Metzinger, Courtney; Berg, Christine

2015-01-01

Young adults with chronic health conditions can experience barriers to work performance, ability, and their present and future worker roles. Work readiness resources can expand individuals' work skills, abilities, and interests. Five work readiness tools are presented (1) building an occupational profile, (2) generating environmental strategies, (3) on-the-job strategy use, and exploration of online tools (4) O*NET® and (5) O*NET® Interest Profiler, along with two theories (Knowles's Andragogy and Lawton's Ecological Model) to guide tool use. Use of these tools can assist young adults to better manage their health and expand their vocational identities for success at work. These approaches and tools support health professionals, community partners, and vocational organizations in their efforts to help young adults with chronic conditions.

Engaging Religious Institutions to Address Racial Disparities in HIV/AIDS: A Case of Academic-Community Partnership

PubMed Central

Szaflarski, Magdalena; Vaughn, Lisa M.; Chambers, Camisha; Harris, Mamie; Ruffner, Andrew; Wess, Yolanda; Mosley, LaSharon; Smith, Chandra

2017-01-01

African Americans face the most severe burden of HIV among all racial and ethnic groups. Direct involvement of faith leaders and faith communities is increasingly suggested as a primary strategy to reduce HIV-related disparities, and Black churches are uniquely positioned to address HIV stigma, prevention, and care in African American communities. The authors describe an academic-community partnership to engage Black churches to address HIV in a predominantly African American, urban, southern Midwest location. The opportunities, process, and challenges in forming this academic-community partnership with Black churches can be used to guide future efforts toward engaging faith institutions, academia, and other community partners in the fight against HIV. PMID:28239643

Vibrio bacteria in raw oysters: managing risks to human health.

PubMed

Froelich, Brett A; Noble, Rachel T

2016-03-05

The human-pathogenic marine bacteria Vibrio vulnificus and V. parahaemolyticus are strongly correlated with water temperature, with concentrations increasing as waters warm seasonally. Both of these bacteria can be concentrated in filter-feeding shellfish, especially oysters. Because oysters are often consumed raw, this exposes people to large doses of potentially harmful bacteria. Various models are used to predict the abundance of these bacteria in oysters, which guide shellfish harvest policy meant to reduce human health risk. Vibrio abundance and behaviour varies from site to site, suggesting that location-specific studies are needed to establish targeted risk reduction strategies. Moreover, virulence potential, rather than simple abundance, should be also be included in future modeling efforts. © 2016 The Author(s).

Resilience Guide: A Collection of Resources on Resilience in Children and Families.

ERIC Educational Resources Information Center

Cesarone, Bernard, Ed.

This guide offers a collection of resources gathered as part of the effort to create the ResilienceNet Web site on the resilience of children and families. The introduction to the guide describes the partnership between ASSIST INTERNATIONAL, INC. and the ERIC Clearinghouse on Elementary and Early Childhood Education that led to the development of…

Troubleshooting Microcomputers. A Technical Guide for Polk County Schools.

ERIC Educational Resources Information Center

Black, B. R.; And Others

This guide was started in 1986 as an effort to pull together a collection of several computer guides that had been written over the previous several years to assist schools in making simple computer repairs. The first of six sections contains general tips and hints, including sections on tool requirements, strobe disk speed adjustment, static…

Alcohol Abuse Prevention: A Comprehensive Guide for Youth Organizations.

ERIC Educational Resources Information Center

Boys' Clubs of America, New York, NY.

This guide, the culmination of a three year Project TEAM effort by the Boys' Clubs of America, describes numerous strategies for developing an alcohol abuse prevention program. The core of this guide consists of program models developed by the Boys' Club project at seven pilot sites. The models presented cover the following areas: peer leadership,…

The Impact of Guided Notes on Post-Secondary Student Achievement: A Meta-Analysis

ERIC Educational Resources Information Center

Larwin, Karen H.; Larwin, David A.

2013-01-01

The common practice of using of guided notes in the post-secondary classroom is not fully appreciated or understood. In an effort to add to the existing research about this phenomenon, the current investigation expands on previously published research and one previously published meta-analysis that examined the impact of guided notes on…

Involvement of the Rat Anterior Cingulate Cortex in Control of Instrumental Responses Guided by Reward Expectancy

ERIC Educational Resources Information Center

Schweimer, Judith; Hauber, Wolfgang

2005-01-01

The anterior cingulate cortex (ACC) plays a critical role in stimulus-reinforcement learning and reward-guided selection of actions. Here we conducted a series of experiments to further elucidate the role of the ACC in instrumental behavior involving effort-based decision-making and instrumental learning guided by reward-predictive stimuli. In…

75 FR 79341 - Proposed Information Collection; Comment Request; Harvest of Pacific Halibut by Guided Sport...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... Collection; Comment Request; Harvest of Pacific Halibut by Guided Sport Charter Vessel Anglers off Alaska... halibut fishing effort and harvest by all user groups, including the guided sport charter sector of the... requirements. The State of Alaska Department of Fish and Game (ADF&G) Division of Sport Fish initiated a...

Building Blocks: A Legislator's Guide to Child Care Policy.

ERIC Educational Resources Information Center

Culkin, Mary L.; Groginsky, Scott; Christian, Steve

The care and education of the youngest children in the United States has become a critical public policy issue affecting millions of families. This guide closely examines the issues and tradeoffs in key child care policy decisions that face state legislators. The guide provides a discussion of state efforts to build supply, improve quality, and…

Computer & manual accident typing for bicyclist accidents : administrator's guide

DOT National Transportation Integrated Search

1983-01-01

This guide provides guidelines and procedures for classifying and analyzing bicyclist-motor vehicle accidents. The approach described herein is part of a systematic effort by the National Highway Traffic Safety Administration (NHTSA) to assist states...

Scoping the polymer genome: A roadmap for rational polymer dielectrics design and beyond

DOE PAGES

Mannodi-Kanakkithodi, Arun; Chandrasekaran, Anand; Kim, Chiho; ...

2017-12-19

The Materials Genome Initiative (MGI) has heralded a sea change in the philosophy of materials design. In an increasing number of applications, the successful deployment of novel materials has benefited from the use of computational methodologies, data descriptors, and machine learning. Polymers have long suffered from a lack of data on electronic, mechanical, and dielectric properties across large chemical spaces, causing a stagnation in the set of suitable candidates for various applications. Extensive efforts over the last few years have seen the fruitful application of MGI principles toward the accelerated discovery of attractive polymer dielectrics for capacitive energy storage. Here,more » we review these efforts, highlighting the importance of computational data generation and screening, targeted synthesis and characterization, polymer fingerprinting and machine-learning prediction models, and the creation of an online knowledgebase to guide ongoing and future polymer discovery and design. We lay special emphasis on the fingerprinting of polymers in terms of their genome or constituent atomic and molecular fragments, an idea that pays homage to the pioneers of the human genome project who identified the basic building blocks of the human DNA. As a result, by scoping the polymer genome, we present an essential roadmap for the design of polymer dielectrics, and provide future perspectives and directions for expansions to other polymer subclasses and properties.« less

State experiences implementing youth sports concussion laws: challenges, successes, and lessons for evaluating impact.

PubMed

Lowrey, Kerri McGowan; Morain, Stephanie R

2014-01-01

While provisions of youth sports concussion laws are very similar, little is known as to how they are being implemented, factors that promote or impede implementation, or the level of compliance in each jurisdiction. We aimed to describe state experiences with implementation in order to inform ongoing efforts to reduce the harm of sports-related traumatic brain injury and to guide future evaluations of the laws' impacts and the development of future public health laws. We conducted key-informant interviews in 35 states with recently enacted concussion legislation. States varied considerably in their readiness and capacity for implementation. Factors facilitating implementation included existing partnerships, procedures, and resources; centralized implementation authority; prior related efforts; and involvement in the policymaking process by those now charged with implementation. Inhibitors included ambiguous statutory language, unclear delegation of authority, and compliance difficulties. Ongoing challenges persist, including primary prevention; determining which providers are qualified to make return-to-play assessments and contents of those assessments; compliance difficulties in rural and under-served areas; and unclear responsibility for enforcement. Despite the similarity of youth sports concussion laws, early evidence suggests there is considerable variation in their implementation. These findings are critical for ongoing empirical investigations to accurately evaluate the laws' provisions and to identify successful legal approaches to protecting young athletes. © 2014 American Society of Law, Medicine & Ethics, Inc.

NASA's future space power needs and requirements

NASA Technical Reports Server (NTRS)

Schnyer, A. D.; Sovie, Ronald J.

1990-01-01

The National Space Policy of 1988 established the U.S.'s long-range civil space goals, and has served to guide NASA's recent planning for future space mission operations. One of the major goals was to extend the human presence beyond earth's boundaries and to advance the scientific knowledge of the solar system. A broad spectrum of potential civil space mission opportunities and interests are currently being investigated by NASA to meet the espoused goals. Participation in many of these missions requires power systems with capabilities far beyond what exists today. In other mission examples, advanced power systems technology could enhance mission performance significantly. Power system requirements and issues that need resolution to ensure eventual mission accomplishment are addressed, in conjunction with the ongoing NASA technology development efforts and the need for even greater innovative efforts to match the ambitious solar exploration mission goals. Particular attention is given to potential lunar surface operations and technology goals, based on investigations to date. It is suggested that the nuclear reactor power systems can best meet long-life requirements as well as dramatically reduce the earth-surface-to-lunar-surface transportation costs due to the lunar day/night cycle impact on the solar system's energy storage mass requirements. The state of the art of candidate power systems and elements for the lunar application and the respective exploration technology goals for mission life requirements from 10 to 25 years are examined.

International perspectives on sharing clinical data with patients.

PubMed

Prey, Jennifer E; Polubriaginof, Fernanda; Kuperman, Gilad J; Tiase, Victoria; Collins, Sarah A; Vawdrey, David K

2016-02-01

Engaging patients in their care has become a topic of increasing importance, and enabling patients to have access to their clinical data is a key aspect of such engagement. We investigated, on an international scale, the current state of approaches for providing patients with access to their own clinical information. Individuals from 28 countries were invited to participate in a cross-sectional semi-structured interview. Interview questions focused on social and cultural influences that affected patient engagement activities, government support for current and planned initiatives, data ownership models, and technical issues. Interviews were conducted with individuals from 16 countries representing six continents. Respondents reported substantive initiatives for providing information to patients in the majority of countries interviewed. These initiatives were diverse in nature and stage of implementation. Enabling patient access to data is occurring on an international scale. There is considerable variability in the level of maturity, the degree of government involvement, the technical infrastructure, and the plans for future development across the world. As informaticians, we are still in the early stages of deploying patient engagement technologies and have yet to identify optimal strategies in this arena. Efforts to improve patient access to data are active on a global-scale. There are many open questions about best practices and much can be learned by adopting an international perspective to guide future implementation efforts. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Using the Whole School, Whole Community, Whole Child Model: Implications for Practice

PubMed Central

Rooney, Laura E; Videto, Donna M; Birch, David A

2015-01-01

BACKGROUND Schools, school districts, and communities seeking to implement the Whole School, Whole Community, Whole Child (WSCC) model should carefully and deliberately select planning, implementation, and evaluation strategies. METHODS In this article, we identify strategies, steps, and resources within each phase that can be integrated into existing processes that help improve health outcomes and academic achievement. Implementation practices may vary across districts depending upon available resources and time commitments. RESULTS Obtaining and maintaining administrative support at the beginning of the planning phase is imperative for identifying and implementing strategies and sustaining efforts to improve student health and academic outcomes. Strategy selection hinges on priority needs, community assets, and resources identified through the planning process. Determining the results of implementing the WSCC is based upon a comprehensive evaluation that begins during the planning phase. Evaluation guides success in attaining goals and objectives, assesses strengths and weaknesses, provides direction for program adjustment, revision, and future planning, and informs stakeholders of the effect of WSCC, including the effect on academic indicators. CONCLUSIONS With careful planning, implementation, and evaluation efforts, use of the WSCC model has the potential of focusing family, community, and school education and health resources to increase the likelihood of better health and academic success for students and improve school and community life in the present and in the future. PMID:26440824

The Conservation Effects Assessment Project (CEAP): a national scale natural resources and conservation needs assessment and decision support tool

NASA Astrophysics Data System (ADS)

Johnson, M.-V. V.; Norfleet, M. L.; Atwood, J. D.; Behrman, K. D.; Kiniry, J. R.; Arnold, J. G.; White, M. J.; Williams, J.

2015-07-01

The Conservation Effects Assessment Project (CEAP) was initiated to quantify the impacts of agricultural conservation practices at the watershed, regional, and national scales across the United States. Representative cropland acres in all major U.S. watersheds were surveyed in 2003-2006 as part of the seminal CEAP Cropland National Assessment. Two process-based models, the Agricultural Policy Environmental eXtender(APEX) and the Soil Water Assessment Tool (SWAT), were applied to the survey data to provide a quantitative assessment of current conservation practice impacts, establish a benchmark against which future conservation trends and efforts could be measured, and identify outstanding conservation concerns. The flexibility of these models and the unprecedented amount of data on current conservation practices across the country enabled Cropland CEAP to meet its Congressional mandate of quantifying the value of current conservation practices. It also enabled scientifically grounded exploration of a variety of conservation scenarios, empowering CEAP to not only inform on past successes and additional needs, but to also provide a decision support tool to help guide future policy development and conservation practice decision making. The CEAP effort will repeat the national survey in 2015-2016, enabling CEAP to provide analyses of emergent conservation trends, outstanding needs, and potential costs and benefits of pursuing various treatment scenarios for all agricultural watersheds across the United States.

Scoping the polymer genome: A roadmap for rational polymer dielectrics design and beyond

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mannodi-Kanakkithodi, Arun; Chandrasekaran, Anand; Kim, Chiho

The Materials Genome Initiative (MGI) has heralded a sea change in the philosophy of materials design. In an increasing number of applications, the successful deployment of novel materials has benefited from the use of computational methodologies, data descriptors, and machine learning. Polymers have long suffered from a lack of data on electronic, mechanical, and dielectric properties across large chemical spaces, causing a stagnation in the set of suitable candidates for various applications. Extensive efforts over the last few years have seen the fruitful application of MGI principles toward the accelerated discovery of attractive polymer dielectrics for capacitive energy storage. Here,more » we review these efforts, highlighting the importance of computational data generation and screening, targeted synthesis and characterization, polymer fingerprinting and machine-learning prediction models, and the creation of an online knowledgebase to guide ongoing and future polymer discovery and design. We lay special emphasis on the fingerprinting of polymers in terms of their genome or constituent atomic and molecular fragments, an idea that pays homage to the pioneers of the human genome project who identified the basic building blocks of the human DNA. As a result, by scoping the polymer genome, we present an essential roadmap for the design of polymer dielectrics, and provide future perspectives and directions for expansions to other polymer subclasses and properties.« less

Primary and secondary prevention of skin cancer in mountain guides: attitude and motivation for or against participation.

PubMed

Zink, A; Thomé, F; Schielein, M; Spinner, C D; Biedermann, T; Tizek, L

2018-05-30

Outdoor professionals such as mountain guides are at a substantial risk of developing non-melanoma skin cancer (NMSC) due to solar ultraviolet radiation (UVR) exposure. Despite major recent primary prevention efforts, studies on secondary skin cancer prevention efforts are limited and corresponding data on outdoor workers scarce. To assess the sun protective behaviour and individual motivations for or against skin cancer screening examinations in the German mountain guide population to aid in the development of effective awareness and prevention strategies. A cross-sectional study among all registered mountain guides in Germany was conducted using a 35-item online questionnaire on primary and secondary prevention of NMSC as well as perceived barriers for prevention. A total of 145 mountain guides participated in the study in January 2017. Of these, 86.2% reported using sunscreen often or always, 62.1% with a sun protection factor (SPF) of 30-50% and 60.7% had undergone dermatological examination by a medical professional. The most common reasons for using secondary prevention efforts were hope of an early diagnosis (77.3%), fear of skin cancer (73.9%) and the intention to be aware of one's own health (70.5%). The main reasons for not doing so were absence of conspicuous skin conditions (63.2%) and feeling healthy (59.6%). Awareness of prevention strategies recommended by the scientific community is low among affected occupationally high-risk mountain guide populations. Understanding the specific needs of this high-risk group is essential for the development of sustainable awareness and prevention strategies. © 2018 European Academy of Dermatology and Venereology.

The National Electronic Library: A Guide to the Future for Library Managers. The Greenwood Library Management Collection.

ERIC Educational Resources Information Center

Pitkin, Gary M., Ed.

As a reference guide for library professionals, this volume helps librarians prepare for the future in the growing electronic environment by examining the historical and theoretical background of the National Electronic Library and assessing the role of libraries in the past, present, and future. The book is divided in two sections: "The…

Venezuela's Bolivarian Schools Project.

ERIC Educational Resources Information Center

Diaz, Maria Magnolia Santamaria

2002-01-01

Discusses efforts by the Venezuelan government to improve the nation's school infrastructure through the Bolivarian Schools Project administered by the Ministry of Education, Culture and Sport. The project set educational principles which are guiding current school building efforts. (EV)

Investigating the Role of Mesoscale Processes and Ice Dynamics in Carbon and Iron Fluxes in a Changing Amundsen Sea (INSPIRE)

NASA Astrophysics Data System (ADS)

Mu, L.; Yager, P. L.; St-Laurent, P.; Dinniman, M.; Oliver, H.; Stammerjohn, S. E.; Sherrell, R. M.; Hofmann, E. E.

2016-02-01

The Amundsen Sea, in the remote S. Pacific sector of the Southern Ocean, is one of the least studied Antarctic continental shelf regions. It shares key processes with other W. Antarctic shelf regions, such as formation of a recurring polynya, important ice shelf-ocean linkages, and high biological production, but has unique characteristics as well. The Amundsen Sea Polynya (ASP), features 1) large intrusions of modified Circumpolar Deep Water (mCDW) onto the continental shelf, 2) the fastest melting ice sheets in Antarctica, 3) the most productive coastal polynya and a large atmospheric CO2 sink, and 4) very rapid declines in seasonal sea ice. Here we report on a new effort for this region that unites independent, state-of-the-art modeling and field data synthesis efforts to address important unanswered questions about carbon fluxes, iron supply, and climate sensitivity in this key region of the coastal Antarctic. Following on the heels of a highly successful oceanographic field program, the Amundsen Sea Polynya International Research Expedition (ASPIRE; which sampled the ASP with high spatial resolution during the onset of the enormous phytoplankton bloom of 2011), the INSPIRE project is a collaboration between ASPIRE senior scientists and an experienced team of physical and biogeochemical modelers who can use ASPIRE field data to both validate and extend the capabilities of an existing Regional Ocean Modeling System (ROMS) for the Amundsen Sea. This new effort will add biology and biogeochemistry (including features potentially unique to the ASP region) to an existing physical model, allowing us to address key questions about bloom mechanisms and climate sensitivity that could not be answered by field campaigns or modeling alone. This project is expected to generate new insights and hypotheses that will ultimately guide sampling strategies of future field efforts investigating how present and future climate change impacts this important region of the world.

Nanoinformatics workshop report: Current resources, community needs, and the proposal of a collaborative framework for data sharing and information integration.

PubMed

Harper, Stacey L; Hutchison, James E; Baker, Nathan; Ostraat, Michele; Tinkle, Sally; Steevens, Jeffrey; Hoover, Mark D; Adamick, Jessica; Rajan, Krishna; Gaheen, Sharon; Cohen, Yoram; Nel, Andre; Cachau, Raul E; Tuominen, Mark

2013-01-01

The quantity of information on nanomaterial properties and behavior continues to grow rapidly. Without a concerted effort to collect, organize and mine disparate information coming out of current research efforts, the value and effective use of this information will be limited at best. Data will not be translated to knowledge. At worst, erroneous conclusions will be drawn and future research may be misdirected. Nanoinformatics can be a powerful approach to enhance the value of global information in nanoscience and nanotechnology. Much progress has been made through grassroots efforts in nanoinformatics resulting in a multitude of resources and tools for nanoscience researchers. In 2012, the nanoinformatics community believed it was important to critically evaluate and refine currently available nanoinformatics approaches in order to best inform the science and support the future of predictive nanotechnology. The Greener Nano 2012: Nanoinformatics Tools and Resources Workshop brought together informatics groups with materials scientists active in nanoscience research to evaluate and reflect on the tools and resources that have recently emerged in support of predictive nanotechnology. The workshop goals were to establish a better understanding of current nanoinformatics approaches and to clearly define immediate and projected informatics infrastructure needs of the nanotechnology community. The theme of nanotechnology environmental health and safety (nanoEHS) was used to provide real-world, concrete examples on how informatics can be utilized to advance our knowledge and guide nanoscience. The benefit here is that the same properties that impact the performance of products could also be the properties that inform EHS. From a decision management standpoint, the dual use of such data should be considered a priority. Key outcomes include a proposed collaborative framework for data collection, data sharing and information integration.

Nanoinformatics workshop report: Current resources, community needs, and the proposal of a collaborative framework for data sharing and information integration

PubMed Central

Harper, Stacey L; Hutchison, James E; Baker, Nathan; Ostraat, Michele; Tinkle, Sally; Steevens, Jeffrey; Hoover, Mark D; Adamick, Jessica; Rajan, Krishna; Gaheen, Sharon; Cohen, Yoram; Nel, Andre; Cachau, Raul E; Tuominen, Mark

2014-01-01

The quantity of information on nanomaterial properties and behavior continues to grow rapidly. Without a concerted effort to collect, organize and mine disparate information coming out of current research efforts, the value and effective use of this information will be limited at best. Data will not be translated to knowledge. At worst, erroneous conclusions will be drawn and future research may be misdirected. Nanoinformatics can be a powerful approach to enhance the value of global information in nanoscience and nanotechnology. Much progress has been made through grassroots efforts in nanoinformatics resulting in a multitude of resources and tools for nanoscience researchers. In 2012, the nanoinformatics community believed it was important to critically evaluate and refine currently available nanoinformatics approaches in order to best inform the science and support the future of predictive nanotechnology. The Greener Nano 2012: Nanoinformatics Tools and Resources Workshop brought together informatics groups with materials scientists active in nanoscience research to evaluate and reflect on the tools and resources that have recently emerged in support of predictive nanotechnology. The workshop goals were to establish a better understanding of current nanoinformatics approaches and to clearly define immediate and projected informatics infrastructure needs of the nanotechnology community. The theme of nanotechnology environmental health and safety (nanoEHS) was used to provide real-world, concrete examples on how informatics can be utilized to advance our knowledge and guide nanoscience. The benefit here is that the same properties that impact the performance of products could also be the properties that inform EHS. From a decision management standpoint, the dual use of such data should be considered a priority. Key outcomes include a proposed collaborative framework for data collection, data sharing and information integration. PMID:24454543

Systematizing the Delivery of Local Employment and Training Services. The Job Center Technical Assistance Guide.

ERIC Educational Resources Information Center

Wisconsin State Dept. of Industry, Labor and Human Relations, Madison.

This technical assistance guide was developed to consolidate a statewide understanding of the effort to systematize the delivery of employment and training programs through the local formation of job centers in Wisconsin, and to provide a compilation, drawn from 20 local models, that explains how the programs are delivered. The guide is organized…

Developing Mathematical Talent: A Guide for Teachers and Parents of Gifted Students.

ERIC Educational Resources Information Center

Assouline, Susan; Lupkowski-Shoplik, Ann

This book is a guide to educating and nurturing children with mathematical talent. Chapter 1 presents and refutes 12 myths about mathematically talented students, especially the idea that it is best not to deviate from regular programming. The second chapter is a guide for parents in their efforts to advocate for their child in the regular school…

Integrating Phosphorus Movement with Soil and Water Loss in the Daily Erosion Project

NASA Astrophysics Data System (ADS)

Sklenar, Tim; Perez-Bidegain, Mario; Cruse, Richard; Gelder, Brian; Herzmann, Daryl

2016-04-01

The Daily Erosion Project (DEP) is an ongoing modelling effort which is now in its second generation. DEP provides comprehensive and dynamic estimates of sediment delivery, soil erosion, and hill slope runoff for agricultural land areas across the Midwestern United States every day for Hydrologic Unit Code 12 (HUC 12) size watersheds. Results are posted every morning on the Internet at dailyerosion.org. Currently DEP covers all of Iowa and portions of Kansas and Minnesota, but expansion of coverage is ongoing. The integration of highly resolute spatial and temporal climate data, soil properties, crop rotation and residue management data affords the opportunity to test the effects of using multiple conservation practices on the transport and fate of water borne nutrients, especially phosphorus, on the Midwestern United States agricultural landscapes. Understanding the interaction of different environmental and land management practices on phosphorus movement will allow data from the DEP to guide conservation efforts as expansion continues into surrounding Midwestern states. The presentation will provide an overview of the DEP technology, including how input data are derived and used to make daily erosion estimates on over 200,000 flowpaths in the modelling area, as well as a discussion of the ongoing phosphorus transport modelling efforts and plans for future expansion (both land area and model functionality).

Self-control and Task Timing Shift Self-efficacy and Influence Willingness to Engage in Effortful Tasks

PubMed Central

Ein-Gar, Danit; Steinhart, Yael

2017-01-01

Self-efficacy constitutes a key factor that influences people's inclination to engage in effortful tasks. In this study, we focus on an interesting interplay between two prominent factors known to influence engagement in effortful tasks: the timing of the task (i.e., whether the task is scheduled to take place in the near or distant future) and individuals' levels of self-control. Across three studies, we show that these two factors have an interacting effect on self-efficacy. Low self-control (LSC) individuals report higher self-efficacy for distant-future effortful tasks than for near-future tasks, whereas high self-control (HSC) individuals report higher self-efficacy for near-future tasks than for distant future tasks. We further demonstrate how self-efficacy then molds individuals' willingness to engage in those effortful tasks. Given that a particular task may comprise effortful aspects alongside more enjoyable aspects, we show that the effects we observe emerge with regard to a task whose effortful aspects are salient and that the effects are eliminated when the enjoyable aspects of that same task are highlighted. PMID:29075225

The good CPD guide: A practical guide to managed continuing professional development in medicine Janet Grant The good CPD guide: A practical guide to managed continuing professional development in medicine Radcliffe Publishing 190pp £29.99 9781846195709 1846195705 [Formula: see text].

PubMed

2012-02-10

DURING HARD times, when education budgets decrease, the purpose of continuing professional development (CPD) programmes must be made clear to practitioners and services. Clarity is crucial in ensuring that CPD programmes receive adequate funding, and that enough time and professional effort are devoted to them.

Advances in Psychiatric Diagnosis: Past, Present, and Future.

PubMed

North, Carol S; Surís, Alina M

2017-04-26

This editorial examines controversies identified by the articles in this special issue, which explore psychopathology in the broad history of the classification of selected psychiatric disorders and syndromes over time through current American criteria. Psychiatric diagnosis has a long history of scientific investigation and application, with periods of rapid change, instability, and heated controversy associated with it. The articles in this issue examine the history of psychiatric nomenclature and explore current and future directions in psychiatric diagnosis through the various versions of accepted diagnostic criteria and accompanying research literature addressing the criteria. The articles seek to guide readers in appreciating the complexities of psychiatric diagnosis as the field of psychiatry pushes forward toward future advancements in diagnosis. Despite efforts of many scientists to advance a diagnostic classification system that incorporates neuroscience and genetics, it has been argued that it may be premature to attempt to move to a biologically-based classification system, because psychiatric disorders cannot yet be fully distinguished by any specific biological markers. For now, the symptom-based criteria that the field has been using continue to serve many essential purposes, including selection of the most effective treatment, communication about disease with colleagues, education about psychiatric illness, and support for ongoing research.

Future Visions for Scientific Human Exploration

NASA Astrophysics Data System (ADS)

Garvin, James

2002-01-01

Human exploration has always played a vital role within NASA, in spite of current perceptions that today it is adrift as a consequence of the resource challenges associated with construction and operation of the International Space Station (ISS). On the basis of the significance of human spaceflight within NASA's overall mission, periodic evaluation of its strategic position has been conducted by various groups, most recently exemplified by the recent Human Exploration and Development of Space Enterprise Strategic Plan. While such reports paint one potential future pathway, they are necessarily constrained by the ground rules and assumptions under which they are developed. An alternate approach, involving a small team of individuals selected as "brainstormers," has been ongoing within NASA for the past two years in an effort to capture a vision of a long-term future for human spaceflight not limited by nearer-term "point design" solutions. This paper describes the guiding principles and concepts developed by this team. It is not intended to represent an implementation plan, but rather one perspective on what could result as human beings extend their range of experience in spaceflight beyond today's beach-head of Low-Earth Orbit (LEO).

Recruiting future neuroscientists: what asking the recruits can teach us.

PubMed

Willcockson, Irmgard U; Phelps, Cynthia L

2004-12-01

Many different strategies are used to recruit students into scientific research careers, including neuroscience research. These strategies are rarely based on knowledge about students; instead, activities are selected based on their ease of implementation. The goal of the LEARN Project is to encourage high school students into mental health science research using the theme of learning and memory. One intervention the authors developed is five Web-based biographies introducing students to contemporary neuroscientist role models studying learning and memory. To guide the design of this intervention, the authors created a survey to determine where students obtain career information and who and what influences their career selection. In a convenience sample of 124 students, the authors found that almost all students use the Internet for information about careers, in addition to consulting family members and teachers. Students' career selections are influenced most by family members, teachers, and people already in the field. The most important factors students look for in their future career are money, fun, and a good match between current interests and future careers. The data affirm the value of outreach efforts that go beyond students to include a broader audience of parents and teachers who play a critical role in career selection.

Occupant restraint legislation handbook : a guide for proponents

DOT National Transportation Integrated Search

1979-02-01

The document is intended to serve as a working guide to individuals and organizations involved in efforts to gain legislative approval of general safety belt usage laws or child restraint laws. The information contained in this handbook falls into tw...

Intelligent Transportation Systems (ITS) logical architecture : volume 3 : data dictionary

DOT National Transportation Integrated Search

1982-01-01

A Guide to Reporting Highway Statistics is a principal part of Federal Highway Administration's comprehensive highway information collection effort. This Guide has two objectives: 1) To serve as a reference to the reporting system that the Federal Hi...

Environmental Issues and Sustainable Futures: A Critical Guide To Recent Books, Reports, and Periodicals. A "Future Survey" Guidebook.

ERIC Educational Resources Information Center

Marien, Michael

This guide seeks to sort the flood of information written about environmental issues and sustainable societies in recent years and order it in some way. A total of 450 document abstracts are presented here, most of which are on books and think tank reports. These items first appeared in "Future Survey" (journal) and were published…

Questions About Cervical and Breast Cancer Screening Knowledge, Practice, and Outcomes: A Review of Demographic and Health Surveys.

PubMed

Viens, Laura; Perin, Doug; Senkomago, Virginia; Neri, Antonio; Saraiya, Mona

2017-05-01

United Nation's Sustainable Development Goals and the World Health Organization's Global Monitoring Framework support a strong global commitment to reducing the high burden of cervical and breast cancers among low- and middle-income countries. Strategies include vaccination, screening, and early diagnosis. Population-based surveys, such as those conducted by the Demographic and Health Surveys (DHS) Program, can collect the information needed to guide cancer control efforts in a standardized comparable manner. We identified and evaluated the breadth of breast and cervical cancer screening information that was collected by the DHS from 1984 through 2015. Then, we determined if these surveys currently provide the specific and measurable data about both the quantity and quality of cancer screening needed to guide national efforts to reduce the overall effects of cervical and breast cancers. We searched the DHS website to identify surveys conducted between the start of the DHS Program in 1984 and November 2015 that included questions about breast and cervical cancer screening. The relevant questions were extracted from the questionnaire, translated into English, and grouped by themes. Of the 90 countries where DHS surveys have been implemented, cervical cancer screening questions were included in 22 countries (24.4%) and breast cancer screening questions in 18 countries (20.0%). The common themes identified were disease knowledge, screening knowledge, screening practice, and screening outcomes. Most countries with survey questionnaires available for review addressed at least one aspect of screening practice (88.9% of cervical and 87.5% of breast), although few countries queried knowledge and outcomes. Questions that assess varied aspects of breast and cervical cancer screening have been incorporated into relatively few DHS surveys. The themes identified could guide the design of a standard set of questions for use in future population-based surveys and enable evaluation beyond the existence of screening, which would include assessment of the quality and impact of cervical and breast cancer screening.

A Framework for Prioritizing NOAA's Climate Data Portfolio to Improve Relevance and Value

NASA Astrophysics Data System (ADS)

Privette, J. L.; Hutchins, C.; McPherson, T.; Wunder, D.

2016-12-01

NOAA's National Centers for Environmental Information (NCEI) is the largest civilian environmental data archive in the world. NCEI operationally provides hundreds of long term homogeneous climate data records and assessments that describe Earth's atmosphere, oceans and land surface. For decades, these data have underpinned leading climate research and modeling efforts and provided key insights into weather and climate changes. Recently, NCEI has increased support for economic and societal sectors beyond climate research by emphasizing use-inspired product development and services. Accordingly, NCEI has begun comprehensively assessing customer needs and user applications. In parallel, NCEI is analyzing and adjusting its full product portfolio to best address those needs and applications. In this presentation, we will describe NCEI's new approaches to capturing needs, performing use analytics, and molding a more responsive portfolio. We will summarize the findings of a quantitative relevance- and cost-scoring analysis that suggests the relative effectiveness of NCEI science and service investments. Finally, we will describe NCEI's effort to review, document and validate customer-driven product requirements. Results will help guide future prioritization of measurements, research and development, and product services.

Neurobehavioural correlates of body mass index and eating behaviours in adults: A systematic review

PubMed Central

Vainik, Uku; Dagher, Alain; Dubé, Laurette; Fellows, Lesley K

2014-01-01

The worldwide increase in obesity has spurred numerous efforts to understand the regulation of eating behaviours and underlying brain mechanisms. These mechanisms can affordably be studied via neurobehavioural measures. Here, we systematically review these efforts, evaluating neurocognitive tests and personality questionnaires based on: a) consistent relationship with obesity and eating behaviour, and b) reliability. We also considered the measures’ potential to shed light on the brain mechanisms underlying these individual differences. Sixty-six neurocognitive tasks were examined. Less than 11%, mainly measures of executive functions and food motivation, yielded both replicated and reliable effects. Several different personality questionnaires were consistently related to BMI. However, further analysis found that many of these questionnaires relate closely to Conscientiousness, Extraversion and Neuroticism within the Five-Factor Model of personality. Both neurocognitive tests and personality questionnaires suggest that the critical neural systems related to individual differences in obesity are lateral prefrontal structures underpinning self-control and striatal regions implicated in food motivation. This review can guide selection of the highest yield neurobehavioural measures for future studies. PMID:23261403

A Cognitive Ecological Model of Women’s Response to Male Sexual Coercion in Dating

PubMed Central

Nurius, Paula S.; Norris, Jeanette

2015-01-01

SUMMARY We offer a theoretical model that consolidates background, environmental, and intrapersonal variables related to women’s experience of sexual coercion in dating into a coherent ecological framework and present for the first time a cognitive analysis of the processes women use to formulate responses to sexual coercion. An underlying premise for this model is that a woman’s coping response to sexual coercion by an acquaintance is mediated through cognitive processing of background and situational influences. Because women encounter this form of sexual coercion in the context of relationships and situations that they presume will follow normative expectations (e.g., about making friends, socializing and dating), it is essential to consider normative processes of learning, cognitive mediation, and coping guiding their efforts to interpret and respond to this form of personal threat. Although acts of coercion unquestionably remain the responsibility of the perpetrator, a more complete understanding of the multilevel factors shaping women’s perception of and response to threats can strengthen future inquiry and prevention efforts. PMID:25729157

TECHNOLOGY TRANSFER TO U.S. INDEPENDENT OIL AND NATURAL GAS PRODUCERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unknown

1998-10-31

In pursuing its mission of helping U.S. independent oil and gas producers make timely, informed technology decisions, the Petroleum Technology Transfer Council (PTTC) functions as a cohesive national organization that implements industry's directives through active regional programs. The role of the national headquarters (HQ) organization includes planning and managing the PTTC program, conducting nation-wide technology transfer activities, and implementing a comprehensive communications effort. PTTC relies on 10 Regional Lead Organizations (RLOs) as its main program delivery mechanism to industry. Through its regions, PTTC connects with independent oil and gas producers--through technology workshops, resources centers, websites, newsletters, and other outreach efforts.more » The organization effectively combines federal, state, and industry funding to achieve important goals for all of these sectors. This integrated funding base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results. PTTC is increasingly recognized as a critical resource for information and access to technologies, especially for smaller companies. This technical progress report summarizes PTTC's accomplishments during FY98, and its strategy for achieving further growth in the future.« less

Future Air Transportation System Breakout Series Report

NASA Technical Reports Server (NTRS)

2001-01-01

This presentation discusses: AvSTAR Future System Effort Critically important; Investment in the future; Need to follow a systems engineering process; and Efforts need to be worked in worldwide context

College Student Drinking Research From the 1940s to the Future: Where We Have Been and Where We Are Going

PubMed Central

Kilmer, Jason R.; Cronce, Jessica M.; Larimer, Mary E.

2014-01-01

Objective: College student drinking is not a new phenomenon, yet the field of research studying college student drinking is relatively young. In recognition of the 75th anniversary of what is now the Journal of Studies on Alcohol and Drugs, this article reviews the path from the first article to focus exclusively on college student drinking as the topic (published in 1945) to the current state of the science and attempts to look forward to the next steps in the field’s research agenda. Method: Articles were selected by consensus of the authors from incarnations of the journal and other academic journals based on their relevance to the genesis of current best practices regarding college student drinking prevention. Results: Major eras and themes include (a) early efforts to describe and understand college student drinking; (b) building foundations for prevention and intervention efforts in response to growing concerns about high-risk drinking; (c) the emergence of harm-reduction efforts, normative interventions, and efforts to document campus strategies; (d) efficacious prevention efforts and high-risk drinking; (e) the “Call to Action” Task Force Report from the National Institute on Alcohol Abuse and Alcoholism; and (f) updates to the science (including emerging technology). Conclusions: Understanding the rich history of science related to college drinking prevention should prepare and guide our field for the next 75 years of scientific advances, leading to even greater understanding of the etiology and topology of college student drinking as well as more effective methods to reduce alcohol-related harms. PMID:24565309

College student drinking research from the 1940s to the future: where we have been and where we are going.

PubMed

Kilmer, Jason R; Cronce, Jessica M; Larimer, Mary E

2014-01-01

College student drinking is not a new phenomenon, yet the field of research studying college student drinking is relatively young. In recognition of the 75th anniversary of what is now the Journal of Studies on Alcohol and Drugs, this article reviews the path from the first article to focus exclusively on college student drinking as the topic (published in 1945) to the current state of the science and attempts to look forward to the next steps in the field's research agenda. Articles were selected by consensus of the authors from incarnations of the journal and other academic journals based on their relevance to the genesis of current best practices regarding college student drinking prevention. Major eras and themes include (a) early efforts to describe and understand college student drinking; (b) building foundations for prevention and intervention efforts in response to growing concerns about high-risk drinking; (c) the emergence of harm-reduction efforts, normative interventions, and efforts to document campus strategies; (d) efficacious prevention efforts and high-risk drinking; (e) the "Call to Action" Task Force Report from the National Institute on Alcohol Abuse and Alcoholism; and (f) updates to the science (including emerging technology). Understanding the rich history of science related to college drinking prevention should prepare and guide our field for the next 75 years of scientific advances, leading to even greater understanding of the etiology and topology of college student drinking as well as more effective methods to reduce alcohol-related harms.

Psychosocial work environment and the risk of coronary heart disease.

PubMed

Peter, R; Siegrist, J

2000-06-01

Remarkable changes in the working situation have led to the increasing importance of psychomentally and socio-emotionally demanding conditions at work. With the help of theoretical models, those highly prevalent psychosocial work environments were conceptualized which influence the risk of coronary heart disease by enhanced activation of the autonomic nervous system. One of the most prominent theoretical approaches, the job strain model, and a more recent approach, the effort-reward imbalance model, are discussed in the paper. Findings from prospective and cross-sectional studies indicate that job strain and effort-reward imbalance at work define specific conditions of chronic work stress that are associated with an elevated risk of coronary heart disease (CHD). Respective multivariate odds-ratios range from 1.2 to 5.0 with respect to job strain, and from 1.5 to 6.1 with respect to effort-reward imbalance. These associations are explained neither by established behavioral or biomedical risk factors nor by physical and chemical hazards at work, rather they define independent, new work-related risk conditions. There is additional evidence that effort-reward imbalance may mediate the association of some traditional occupational exposures, such as shift work, with cardiovascular risk: in a cross-sectional study, prevalence odds ratios of hypertension and atherogenic lipids attributable to effort-reward imbalance were relatively highest among shiftworkers as compared to daytime workers. Preliminary results from intervention programs based on the theoretical models document favorable effects on health. Information derived from theoretical models on psychosocial work environment may help to better identify populations at risk and to develop and apply specific, theory-guided preventive activities in the future.

Design Criteria for Future Fuels and Related Power Systems Addressing the Impacts of Non-CO2 Pollutants on Human Health and Climate Change.

PubMed

Schauer, James Jay

2015-01-01

Concerns over the economics, supply chain, and emissions of greenhouse gases associated with the wide use of fossil fuels have led to increasing interest in developing alternative and renewable fuels for stationary power generation and transportation systems. Although there is considerable uncertainty regarding the economic and environmental impacts of alternative and renewable fuels, there is a great need for assessment of potential and emerging fuels to guide research priorities and infrastructure investment. Likewise, there is a great need to identify potential unintended adverse impacts of new fuels and related power systems before they are widely adopted. Historically, the environmental impacts of emerging fuels and power systems have largely focused on carbon dioxide emissions, often called the carbon footprint, which is used to assess impacts on climate change. Such assessments largely ignore the large impacts of emissions of other air pollutants. Given the potential changes in emissions of air pollutants associated with the large-scale use of new and emerging fuels and power systems, there is a great need to better guide efforts to develop new fuels and power systems that can avoid unexpected adverse impacts on the environment and human health. This review covers the nature of emissions, including the key components and impacts from the use of fuels, and the design criteria for future fuels and associated power systems to assure that the non-CO2 adverse impacts of stationary power generation and transportation are minimized.

Principles for research on ethnicity and health: the Leeds Consensus Statement.

PubMed

Mir, Ghazala; Salway, Sarah; Kai, Joe; Karlsen, Saffron; Bhopal, Raj; Ellison, George Th; Sheikh, Aziz

2013-06-01

There is substantial evidence that health and health-care experiences vary along ethnic lines and the need to understand and tackle ethnic health inequalities has repeatedly been highlighted. Research into ethnicity and health raises ethical, theoretical and methodological issues and, as the volume of research in this area grows, so too do concerns regarding its scientific rigour and reporting, and its contribution to reducing inequalities. Guidance may be helpful in encouraging researchers to adopt standard practices in the design, conduct and reporting of research. However, past efforts at introducing such guidance have had limited impact on research practice, and the diversity of disciplinary perspectives on the key challenges and solutions may undermine attempts to derive and promote guiding principles. A consensus building Delphi exercise--the first of its kind in this area of research practice--was undertaken with leading academics, practitioners and policymakers from a broad range of disciplinary backgrounds to assess whether consensus on key principles could be achieved. Ten key principles for conducting research on ethnicity and health emerged, covering: the aims of research in this field; how such research should be framed and focused; key design-related considerations; and the direction of future research. Despite some areas of dispute, participants were united by a common concern that the generation and application of research evidence should contribute to better health-care experiences and health outcomes for minority ethnic people. The principles provide a strong foundation to guide future ethnicity-related research and build a broader international consensus.

Quick Tips Guide for Small Manufacturing Businesses

EPA Pesticide Factsheets

Small manufacturing businesses can use this Quick Tips Guide to be better prepared for future extreme weather events. This guide discusses keeping good records, improving housekeeping procedures, and training employees.

Systems Engineering for Space Exploration Medical Capabilities

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Reilly, Jeffrey; Urbina, Michelle; Hailey, Melinda; Rubin, David; Reyes, David; Hanson, Andrea; Burba, Tyler; McGuire, Kerry; Cerro, Jeffrey;

Computer Guided Instructional Design.

ERIC Educational Resources Information Center

Merrill, M. David; Wood, Larry E.

1984-01-01

Describes preliminary efforts to create the Lesson Design System, a computer-guided instructional design system written in Pascal for Apple microcomputers. Its content outline, strategy, display, and online lesson editors correspond roughly to instructional design phases of content and strategy analysis, display creation, and computer programing…

Ecology, Elementary Teaching Guide.

ERIC Educational Resources Information Center

Gross, Iva Helen

In an effort to provide background information and encourage incorporation of ecological understandings into the curriculum, this teacher's guide has been devised for fourth and fifth grade teachers. It utilizes an activity-oriented approach to discovery and inquiry, outlining behavioral objectives, learning activities, teaching suggestions, and…

Layer moduli of Nebraska pavements for the new Mechanistic-Empirical Pavement Design Guide (MEPDG).

DOT National Transportation Integrated Search

2010-12-01

As a step-wise implementation effort of the Mechanistic-Empirical Pavement Design Guide (MEPDG) for the design : and analysis of Nebraska flexible pavement systems, this research developed a database of layer moduli dynamic : modulus, creep compl...

Aviation Maintenance Technology. General. Curriculum Implementation Guide.

ERIC Educational Resources Information Center

Moore, John, Jr.; And Others

This curriculum implementation guide is a scope and sequence for the general section of a course in aviation maintenance technology. The course materials were prepared through a cooperative effort of airframe and powerplant mechanics, general aviation industry representatives, Federal Aviation Administration representatives, and vocational…

The GPS odograph user's guide

DOT National Transportation Integrated Search

The GPS-based Odograph Prototype (GOP or GPS Odograph) was developed in an effort sponsored by The Federal Highway Administration (FHWA). The purpose of this effort was to develop a means of using inexpensive commercial off-the-self laptop (or notebo...

Safety Assurance Factors for Electronic Health Record Resilience (SAFER): study protocol

PubMed Central

2013-01-01

Background Implementation and use of electronic health records (EHRs) could lead to potential improvements in quality of care. However, the use of EHRs also introduces unique and often unexpected patient safety risks. Proactive assessment of risks and vulnerabilities can help address potential EHR-related safety hazards before harm occurs; however, current risk assessment methods are underdeveloped. The overall objective of this project is to develop and validate proactive assessment tools to ensure that EHR-enabled clinical work systems are safe and effective. Methods/Design This work is conceptually grounded in an 8-dimension model of safe and effective health information technology use. Our first aim is to develop self-assessment guides that can be used by health care institutions to evaluate certain high-risk components of their EHR-enabled clinical work systems. We will solicit input from subject matter experts and relevant stakeholders to develop guides focused on 9 specific risk areas and will subsequently pilot test the guides with individuals representative of likely users. The second aim will be to examine the utility of the self-assessment guides by beta testing the guides at selected facilities and conducting on-site evaluations. Our multidisciplinary team will use a variety of methods to assess the content validity and perceived usefulness of the guides, including interviews, naturalistic observations, and document analysis. The anticipated output of this work will be a series of self-administered EHR safety assessment guides with clear, actionable, checklist-type items. Discussion Proactive assessment of patient safety risks increases the resiliency of health care organizations to unanticipated hazards of EHR use. The resulting products and lessons learned from the development of the assessment guides are expected to be helpful to organizations that are beginning the EHR selection and implementation process as well as those that have already implemented EHRs. Findings from our project, currently underway, will inform future efforts to validate and implement tools that can be used by health care organizations to improve the safety of EHR-enabled clinical work systems. PMID:23587208

Trends in Media Criticism and Accountability in Western Europe: Growing Pressure from Consumers.

ERIC Educational Resources Information Center

Thurston, Carol M.

This paper examines efforts in Western Europe to monitor and guide the performance of the mass media. The evidence indicates that consumers are increasing their efforts to let the media know their wants and needs; these efforts include complaints to national press councils and action in special-interest groups. Local and federal governments have…

Developing, maintaining, and using a body of knowledge for the massage therapy profession.

PubMed

Sefton, Joellen M; Shea, Michael; Hines, Chip

2011-01-01

The diverse field of massage therapy has lacked a formal body of knowledge to serve as a practice and educational foundation and to guide future development. This deficit has hampered the growth of the profession and its acceptance and recognition by the medical and allied health care community. To provide massage therapists, bodyworkers, physicians, educators, and associated allied health care professionals in the United States with a description of the purpose and development of the massage therapy body of knowledge (MTBOK) and recommendations for its future development and utilization. Professional groups in the massage therapy community came together and established a task force to develop a body of knowledge for the profession. Five groups became the stewards for this effort. A nationwide search produced a task force of eight volunteers from diverse areas of the profession charged with the responsibility of researching and developing the MTBOK document. Review of documents, curricula, state laws and regulations, certification exam content, interviews, and public comment resulted in the development of the MTBOK. During development multiple opportunities for comment and discussion by stakeholders (public) were provided in an effort to create a professional consensus. The resulting MTBOK document establishes professional descriptions of the field; scope of practice; knowledge, skills, and abilities for entry-level massage therapists; and definitions for terminology to insure standardization, in order to provide a foundation for future discussion and growth. The MTBOK fulfills the goal for which it was developed, to serve as a foundation for the growth and development of the massage therapy profession as a whole. A living document, it should continue to evolve and grow with the profession. Maintenance and continued stewardship of this document by the massage therapy community is vital for continued professional progress.

Developing, Maintaining, and Using a Body of Knowledge for the Massage Therapy Profession

PubMed Central

Sefton, JoEllen M.; Shea, Michael; Hines, Chip

2011-01-01

Background: The diverse field of massage therapy has lacked a formal body of knowledge to serve as a practice and educational foundation and to guide future development. This deficit has hampered the growth of the profession and its acceptance and recognition by the medical and allied health care community. Purpose: To provide massage therapists, bodyworkers, physicians, educators, and associated allied health care professionals in the United States with a description of the purpose and development of the massage therapy body of knowledge (MTBOK) and recommendations for its future development and utilization. Methods: Professional groups in the massage therapy community came together and established a task force to develop a body of knowledge for the profession. Five groups became the stewards for this effort. A nationwide search produced a task force of eight volunteers from diverse areas of the profession charged with the responsibility of researching and developing the MTBOK document. Review of documents, curricula, state laws and regulations, certification exam content, interviews, and public comment resulted in the development of the MTBOK. During development multiple opportunities for comment and discussion by stakeholders (public) were provided in an effort to create a professional consensus. Results: The resulting MTBOK document establishes professional descriptions of the field; scope of practice; knowledge, skills, and abilities for entry-level massage therapists; and definitions for terminology to insure standardization, in order to provide a foundation for future discussion and growth. Conclusions: The MTBOK fulfills the goal for which it was developed, to serve as a foundation for the growth and development of the massage therapy profession as a whole. A living document, it should continue to evolve and grow with the profession. Maintenance and continued stewardship of this document by the massage therapy community is vital for continued professional progress. PMID:22016755

TECHNOLOGY TRANSFER TO U.S. INDEPENDENT OIL AND NATURAL GAS PRODUCERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unknown

2000-11-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of helping U.S. independent oil and gas producers make timely, informed technology decisions during Fiscal Year 2000 (FY00). Functioning as a cohesive national organization, PTTC has active grassroots programs through its ten Regional Lead Organizations (RLOs) who bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors connect with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, various technical publications and other outreach efforts. These are guided by regional Producer Advisory Groups (PAGs), who are area operatorsmore » and service companies working with the Regional Lead Organizations. The role of the national headquarters (HQ) staff includes planning and managing the PTTC program, conducting nation-wide technology transfer activities, and implementing a comprehensive communications effort. The organization effectively combines federal, state, and industry funding to achieve important goals for all of these sectors. This integrated funding base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results. PTTC is increasingly recognized as a critical resource for information and access to technologies, especially for smaller companies. This technical progress report summarizes PTTC's accomplishments during FY00, which lays the groundwork for further growth in the future. At a time of many industry changes and market movements, the organization has built a reputation and expectation to address industry needs of getting information distributed quickly which can impact the bottom line immediately.« less

Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic

PubMed Central

Rosenbaum, Brooke E; Klein, Rebecca; Hagan, Paa Gyasi; Seadey, Mark-Young; Quarcoo, Naa Larteley; Hoffmann, Rachel; Robinson, Maria; Lartey, Margaret; Leger, Marie C

2017-01-01

Introduction Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Methods We conducted a chart review of new patients presenting to the Korle Bu Teaching Hospital dermatology clinic during 2014. Results Among the 529 patients studied, 700 discrete diagnoses were made. The most commonly diagnosed skin conditions were infections (24.6%) and dermatitis (24.6%); atopic dermatitis (8.4%), acne vulgaris (5.3%) and scabies (5.1%) were the most common specific diagnoses. Among infants, children, and adolescents, the most common diagnosis was atopic dermatitis (31.7%, 30.0%, and 14.9%, respectively). Acne vulgaris (12.0%) was the most common skin condition diagnosed in young adults. Irritant contact dermatitis (6.9%) was most common among adults. Lichen planus (9.9%) was the most commonly diagnosed skin condition in the senior population. Diagnoses made by dermatologists differed from the referral diagnosis documented by primary care providers for 65.8% of patients. The most frequently recommended treatments were antihistamines (47.8%) and topical steroids (38.4%). Only 18 diagnostic biopsies were performed. Conclusion Our study summarizes the skin diseases seen and management practices of Ghanaian dermatologists in a specialized clinic at a large public teaching hospital. The results of this study can help to guide future dermatology education and development efforts in Ghana. PMID:28533848

A restoration genetics guide for coral reef conservation.

PubMed

Baums, Iliana B

2008-06-01

Worldwide degradation of coral reef communities has prompted a surge in restoration efforts. They proceed largely without considering genetic factors because traditionally, coral populations have been regarded as open over large areas with little potential for local adaptation. Since, biophysical and molecular studies indicated that most populations are closed over shorter time and smaller spatial scales. Thus, it is justified to re-examine the potential for site adaptation in corals. There is ample evidence for differentiated populations, inbreeding, asexual reproduction and the occurrence of ecotypes, factors that may facilitate local adaptation. Discovery of widespread local adaptation would influence coral restoration projects mainly with regard to the physical and evolutionary distance from the source wild and/or captive bred propagules may be moved without causing a loss of fitness in the restored population. Proposed causes for loss of fitness as a result of (plant) restoration efforts include founder effects, genetic swamping, inbreeding and/or outbreeding depression. Direct evidence for any of these processes is scarce in reef corals due to a lack of model species that allow for testing over multiple generations and the separation of the relative contributions of algal symbionts and their coral hosts to the overall performance of the coral colony. This gap in our knowledge may be closed by employing novel population genetic and genomics approaches. The use of molecular tools may aid managers in the selection of appropriate propagule sources, guide spatial arrangement of transplants, and help in assessing the success of coral restoration projects by tracking the performance of transplants, thereby generating important data for future coral reef conservation and restoration projects.

TECHNOLOGY TRANSFER TO U.S. INDEPENDENT OIL AND NATURAL GAS PRODUCERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donald Duttlinger

2001-11-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of helping U.S. independent oil and gas producers make timely, informed technology decisions during Fiscal Year 2001 (FY01). Functioning as a cohesive national organization, PTTC has active grassroots programs through its ten Regional Lead Organizations (RLOs). They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, various technical publications and other outreach efforts. These are guided by regional Producer Advisory Groups (PAGs), who are area operatorsmore » and service companies working with the regional networks. The role of the national Headquarters (HQ) staff includes planning and managing the PTTC program, conducting nation wide technology transfer activities, and implementing a comprehensive communications effort. The organization effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy, state, and industry funding to achieve important goals for all of these sectors. This integrated funding base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results. PTTC is increasingly recognized as a critical resource for information and access to technologies, especially for smaller companies without direct contact to R&D efforts. This technical progress report summarizes PTTC's accomplishments during FY01, which lays the groundwork for further growth in the future. At a time of many industry changes and wide market movements, the organization itself is adapting to change. PTTC has built a reputation and expectation among producers and other industry participants to quickly distribute information addressing technical needs. The organization efficiently has an impact on business economics as the focus remains on proven applicable technologies, which target cost reduction and efficiency gains.« less

Perspectives on model forecasts of the 2014-2015 Ebola epidemic in West Africa: lessons and the way forward.

PubMed

Chowell, Gerardo; Viboud, Cécile; Simonsen, Lone; Merler, Stefano; Vespignani, Alessandro

2017-03-01

The unprecedented impact and modeling efforts associated with the 2014-2015 Ebola epidemic in West Africa provides a unique opportunity to document the performances and caveats of forecasting approaches used in near-real time for generating evidence and to guide policy. A number of international academic groups have developed and parameterized mathematical models of disease spread to forecast the trajectory of the outbreak. These modeling efforts often relied on limited epidemiological data to derive key transmission and severity parameters, which are needed to calibrate mechanistic models. Here, we provide a perspective on some of the challenges and lessons drawn from these efforts, focusing on (1) data availability and accuracy of early forecasts; (2) the ability of different models to capture the profile of early growth dynamics in local outbreaks and the importance of reactive behavior changes and case clustering; (3) challenges in forecasting the long-term epidemic impact very early in the outbreak; and (4) ways to move forward. We conclude that rapid availability of aggregated population-level data and detailed information on a subset of transmission chains is crucial to characterize transmission patterns, while ensemble-forecasting approaches could limit the uncertainty of any individual model. We believe that coordinated forecasting efforts, combined with rapid dissemination of disease predictions and underlying epidemiological data in shared online platforms, will be critical in optimizing the response to current and future infectious disease emergencies.

Futures in Business. Interim Guide.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg.

This guide is designed for use by instructors teaching a six-unit course on futures in business. Presented first is a diagram illustrating the place of the course in Manitoba's business education curriculum. The academic, personal management, and teamwork skills that have been deemed critical employability skills required of the Canadian work…

Sub-mm Scale Fiber Guided Deep/Vacuum Ultra-Violet Optical Source for Trapped Mercury Ion Clocks

NASA Technical Reports Server (NTRS)

Yi, Lin; Burt, Eric A.; Huang, Shouhua; Tjoelker, Robert L.

2013-01-01

We demonstrate the functionality of a mercury capillary lamp with a diameter in the sub-mm range and deep ultraviolet (DUV)/ vacuum ultraviolet (VUV) radiation delivery via an optical fiber integrated with the capillary. DUV spectrum control is observed by varying the fabrication parameters such as buffer gas type and pressure, capillary diameter, electrical resonator design, and temperature. We also show spectroscopic data of the 199Hg+ hyper-fine transition at 40.5GHz when applying the above fiber optical design. We present efforts toward micro-plasma generation in hollow-core photonic crystal fiber with related optical design and theoretical estimations. This new approach towards a more practical DUV optical interface could benefit trapped ion clock developments for future ultra-stable frequency reference and time-keeping applications.

Ballistics Analysis of Orion Crew Module Separation Bolt Cover

NASA Technical Reports Server (NTRS)

Howard, Samuel A.; Konno, Kevin E.; Carney, Kelly S.; Pereira, J. Michael

2013-01-01

NASA is currently developing a new crew module to replace capabilities of the retired Space Shuttles and to provide a crewed vehicle for exploring beyond low earth orbit. The crew module is a capsule-type design, which is designed to separate from the launch vehicle during launch ascent once the launch vehicle fuel is expended. The separation is achieved using pyrotechnic separation bolts, wherein a section of the bolt is propelled clear of the joint at high velocity by an explosive charge. The resulting projectile must be contained within the fairing structure by a containment plate. This paper describes an analytical effort completed to augment testing of various containment plate materials and thicknesses. The results help guide the design and have potential benefit for future similar applications.

Epidemiologic Evidence to Guide the Understanding and Prevention of Gun Violence.

PubMed

Webster, Daniel W; Cerdá, Magdalena; Wintemute, Garen J; Cook, Philip J

2016-01-01

Gunfire from assaults, suicides, and unintentional shootings exacts an enormous burden on public health globally. The epidemiologic reviews in this special issue enhance our understanding of various forms of gun violence, inform interventions, and help chart directions for future research. The available science, however, is limited to answer many important questions necessary for mounting successful efforts to reduce gun violence. Certain data are lacking, and there are numerous analytical challenges to deriving unbiased estimates of policy impacts. Significant investments in research over the long term are warranted to answer questions central to successful prevention of gun violence. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Small Engine Component Technology (SECT) study. Program report

NASA Technical Reports Server (NTRS)

Almodovar, E.; Exley, T.; Kaehler, H.; Schneider, W.

1986-01-01

The study was conducted to identify high payoff technologies for year 2000 small gas turbine applications and to provide a technology plan for guiding future research and technology efforts. A regenerative cycle turboprop engine was selected for a 19 passenger commuter aircraft application. A series of engines incorporating eight levels of advanced technologies were studied and their impact on aircraft performance was evaluated. The study indicated a potential reduction in fuel burn of 38.3 percent. At $1.00 per gallon fuel price, a potential DOC benefit of 12.5 percent would be achieved. At $2.00 per gallon, the potential DOC benefit would increase to 17.0 percent. Four advanced technologies are recommended and appropriate research and technology programs were established to reach the year 2000 goals.

Advances and Future Applications of Augmented Peripheral Nerve Regeneration

PubMed Central

Jones, Salazar; Eisenberg, Howard M.; Jia, Xiaofeng

2016-01-01

Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of efforts to improve surgical outcomes are discussed. Improvements in tissue engineering that have allowed for the use of synthetic conduits seeded with neurotrophic factors are highlighted. Selected pre-clinical and available clinical data using cell based methods such as Schwann cell, undifferentiated, and differentiated stem cell transplantation to guide and enhance peripheral nerve regeneration are presented. The limitations that still exist in the utility of neurotrophic factors and cell-based therapies are outlined. Strategies that are most promising for translation into the clinical arena are suggested. PMID:27618010

From Tomography to Material Properties of Thermal Protection Systems

NASA Technical Reports Server (NTRS)

Mansour, Nagi N.; Panerai, Francesco; Ferguson, Joseph C.; Borner, Arnaud; Barnhardt, Michael; Wright, Michael

2017-01-01

A NASA Ames Research Center (ARC) effort, under the Entry Systems Modeling (ESM) project, aims at developing micro-tomography (micro-CT) experiments and simulations for studying materials used in hypersonic entry systems. X-ray micro-tomography allows for non-destructive 3D imaging of a materials micro-structure at the sub-micron scale, providing fiber-scale representations of porous thermal protection systems (TPS) materials. The technique has also allowed for In-situ experiments that can resolve response phenomena under realistic environmental conditions such as high temperature, mechanical loads, and oxidizing atmospheres. Simulation tools have been developed at the NASA Ames Research Center to determine material properties and material response from the high-fidelity tomographic representations of the porous materials with the goal of informing macroscopic TPS response models and guiding future TPS design.

Shipper's guide for proper stowage of intermodal containers for ocean transport

DOT National Transportation Integrated Search

2000-01-01

This short guide has been prepared in an effort to further the successful intermodal carriage of cargo in answer to the request of shippers. This booklet has been compiled as a generalized approach to intermodal transport and door-to-door shipments w...

Creation of the selection list for the Experiment Scheduling Program (ESP)

NASA Technical Reports Server (NTRS)

Deuermeyer, B. L.; Shannon, R. E.; Underbrink, A. J., Jr.

1986-01-01

The efforts to develop a procedure to construct selection groups to augment the Experiment Scheduling Program (ESP) are summarized. Included is a User's Guide and a sample scenario to guide in the use of the software system that implements the developed procedures.

The future of image-guided radiotherapy will be MR guided

PubMed Central

Wen, Zhifei; Sadagopan, Ramaswamy; Wang, Jihong; Ibbott, Geoffrey S

2017-01-01

Advances in image-guided radiotherapy (RT) have allowed for dose escalation and more precise radiation treatment delivery. Each decade brings new imaging technologies to help improve RT patient setup. Currently, the most frequently used method of three-dimensional pre-treatment image verification is performed with cone beam CT. However, more recent developments have provided RT with the ability to have on-board MRI coupled to the teleradiotherapy unit. This latest tool for treating cancer is known as MR-guided RT. Several varieties of these units have been designed and installed in centres across the globe. Their prevalence, history, advantages and disadvantages are discussed in this review article. In preparation for the next generation of image-guided RT, this review also covers where MR-guided RT might be heading in the near future. PMID:28256898

Local calibration of the MEPDG for flexible pavement design.

DOT National Transportation Integrated Search

2011-10-01

In an effort to move toward pavement designs that employ mechanistic principles, the AASHTO Joint : Task Force on Pavements initiated an effort in 1996 to develop an improved pavement design guide. The : project called for the development of a design...

Product and Production System Design. Grade 11-12. Course #8175 (Semester). Technology Education Course Guide. Industrial Arts/Technology Education.

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

This guide is intended for use in teaching a course in the sequential tasks that change a designer's idea into a completed product. Emphasis is placed on the design of a product and the manufacturing system needed to produce it. The first two sections discuss the guide's development within the framework of North Carolina's efforts to improve…

Water Matters. Water Resources Teacher's Guide, Vol. 1.

ERIC Educational Resources Information Center

Kauffman, Sue Cox

This teachers guide is designed to accompany a series of posters developed through the U.S. Geological Survey's Water Resources Education Initiative, a cooperative effort between public and private education interests. It provides teacher guidance, background information, suggestions for a variety of classroom activities, and supplemental resource…

Minnesota Early Childhood Indicators of Progress: A Resource Guide.

ERIC Educational Resources Information Center

2000

Stressing the importance of collective efforts among families, early childhood care and education programs, communities, and policymakers in supporting the learning and development of children, this resource guide provides a framework for understanding and communicating a common set of developmentally appropriate expectations for young children…

Choosing the route to traveler information systems deployment : decision factors for creating public-private business plans : an action guide

DOT National Transportation Integrated Search

1998-01-01

This document presents a guide designed to help public private partnerships in their efforts to provide Advanced Traveler Information Systems (ATIS) services. It first examines why ATIS can be useful in managing transportation networks and increasing...

76 FR 53136 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... will be asked about key aspects of their program's structure, activities, and collaborative efforts... per response (in respondent hours) State Health Department Leadership. Interview Guide for Health 7 1 45/60 Department Leadership. CCC Programs Site Visit Preparation..... 7 1 45/60 Interview Guide for...

Comprehensive Metric Education Project: Implementing Metrics at a District Level Administrative Guide.

ERIC Educational Resources Information Center

Borelli, Michael L.

This document details the administrative issues associated with guiding a school district through its metrication efforts. Issues regarding staff development, curriculum development, and the acquisition of instructional resources are considered. Alternative solutions are offered. Finally, an overall implementation strategy is discussed with…

Ozone Layer Educator's Guide.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC.

This guide has been developed through a collaborative effort involving the U.S. Environmental Protection Agency (EPA), the National Oceanic and Atmospheric Administration (NOAA), and the National Aeronautics and Space Administration (NASA). It is part of an ongoing commitment to ensure that the results of scientific research on ozone depletion are…

Body composition during fetal development and infancy through the age of 5 years

PubMed Central

Toro-Ramos, T; Paley, C; Pi-Sunyer, FX; Gallagher, D

2015-01-01

Fetal body composition is an important determinant of body composition at birth, and it is likely to be an important determinant at later stages in life. The purpose of this work is to provide a comprehensive overview by presenting data from previously published studies that report on body composition during fetal development in newborns and the infant/child through 5 years of age. Understanding the changes in body composition that occur both in utero and during infancy and childhood, and how they may be related, may help inform evidence-based practice during pregnancy and childhood. We describe body composition measurement techniques from the in utero period to 5 years of age, and identify gaps in knowledge to direct future research efforts. Available literature on chemical and cadaver analyses of fetal studies during gestation is presented to show the timing and accretion rates of adipose and lean tissues. Quantitative and qualitative aspects of fetal lean and fat mass accretion could be especially useful in the clinical setting for diagnostic purposes. The practicality of different pediatric body composition measurement methods in the clinical setting is discussed by presenting the assumptions and limitations associated with each method that may assist the clinician in characterizing the health and nutritional status of the fetus, infant and child. It is our hope that this review will help guide future research efforts directed at increasing the understanding of how body composition in early development may be associated with chronic diseases in later life. PMID:26242725

Jobs for the Future.

ERIC Educational Resources Information Center

Business and Professional Women's Foundation, Washington, DC.

This guide is intended to assist women in selecting and preparing for occupations that will either be in demand or continue to be in demand in the future. The first part is a guide to evaluating an occupation. It covers the following topics: costs and benefits (skills needed, training requirements, availability of training, costs of training,…

Future Aspiring Aviators, Primary: An Aviation Curriculum Guide K-3

DOT National Transportation Integrated Search

1995-01-01

Prepared ca. 1995. The Federal Aviation Administration is pleased to present the Aviation Education Teacher's Guide Series. The series includes four publications specifically designed as resources to those interested in aviation education. The guides...

The human anatomy teacher-scholar: Meeting the expectations of educational outcomes research, course content innovation, and textbook innovation for educational scholarship

NASA Astrophysics Data System (ADS)

Eckel, Christine Marie

A human anatomy teacher-scholar is a scholar whose area of expertise includes content knowledge of the anatomical sciences (gross anatomy, histology, embryology, and/or neuroanatomy) and whose research interests and focus are centered in medical educational outcomes. The projects described in this dissertation represent endeavors I engaged in to become a human anatomy teacher-scholar. These projects included: (1) prospectively testing a hypothesis, and performing outcomes assessment in a field for which little data (theory) exist (dissection guide educational research project), (2) creating innovative course content that bridged disciplines (cadaver autopsy project), and (3) composing original teaching material for a specific audience (human anatomy laboratory manual). The training of a human anatomy teacher-scholar emphasizes knowledge acquisition in both the basic sciences (particularly gross anatomy) and in educational outcomes research methodology and theory. Therefore, human anatomy teacher-scholars are positioned to create innovative course content and materials and assess the innovations to guide future efforts. These are important skills for faculty members involved in the education of medical students in the U.S. as the medical education system in the U.S. continues to evolve.

Nanotopography-guided tissue engineering and regenerative medicine.

PubMed

Kim, Hong Nam; Jiao, Alex; Hwang, Nathaniel S; Kim, Min Sung; Kang, Do Hyun; Kim, Deok-Ho; Suh, Kahp-Yang

2013-04-01

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-defined structures of the extracellular matrix (ECM). The organization of ECM is frequently hierarchical from nano to macro, with many proteins forming large scale structures with feature sizes up to several hundred microns. Inspired from these natural designs of ECM, nanotopography-guided approaches have been increasingly investigated for the last several decades. Results demonstrate that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation. In this review, we provide an extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues. We first characterize the role of various nanostructures in human tissues with respect to each tissue-specific function. Then, we describe various fabrication methods in terms of patterning principles and material characteristics. Finally, we summarize the applications of nanotopography to various tissues, which are classified into four types depending on their functions: protective, mechano-sensitive, electro-active, and shear stress-sensitive tissues. Some limitations and future challenges are briefly discussed at the end. Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.

A new age in functional genomics using CRISPR/Cas9 in arrayed library screening.

PubMed

Agrotis, Alexander; Ketteler, Robin

2015-01-01

CRISPR technology has rapidly changed the face of biological research, such that precise genome editing has now become routine for many labs within several years of its initial development. What makes CRISPR/Cas9 so revolutionary is the ability to target a protein (Cas9) to an exact genomic locus, through designing a specific short complementary nucleotide sequence, that together with a common scaffold sequence, constitute the guide RNA bridging the protein and the DNA. Wild-type Cas9 cleaves both DNA strands at its target sequence, but this protein can also be modified to exert many other functions. For instance, by attaching an activation domain to catalytically inactive Cas9 and targeting a promoter region, it is possible to stimulate the expression of a specific endogenous gene. In principle, any genomic region can be targeted, and recent efforts have successfully generated pooled guide RNA libraries for coding and regulatory regions of human, mouse and Drosophila genomes with high coverage, thus facilitating functional phenotypic screening. In this review, we will highlight recent developments in the area of CRISPR-based functional genomics and discuss potential future directions, with a special focus on mammalian cell systems and arrayed library screening.

Improving our understanding of multi-tasking in healthcare: Drawing together the cognitive psychology and healthcare literature.

PubMed

Douglas, Heather E; Raban, Magdalena Z; Walter, Scott R; Westbrook, Johanna I

2017-03-01

Multi-tasking is an important skill for clinical work which has received limited research attention. Its impacts on clinical work are poorly understood. In contrast, there is substantial multi-tasking research in cognitive psychology, driver distraction, and human-computer interaction. This review synthesises evidence of the extent and impacts of multi-tasking on efficiency and task performance from health and non-healthcare literature, to compare and contrast approaches, identify implications for clinical work, and to develop an evidence-informed framework for guiding the measurement of multi-tasking in future healthcare studies. The results showed healthcare studies using direct observation have focused on descriptive studies to quantify concurrent multi-tasking and its frequency in different contexts, with limited study of impact. In comparison, non-healthcare studies have applied predominantly experimental and simulation designs, focusing on interleaved and concurrent multi-tasking, and testing theories of the mechanisms by which multi-tasking impacts task efficiency and performance. We propose a framework to guide the measurement of multi-tasking in clinical settings that draws together lessons from these siloed research efforts. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Capability Roadmap Development for Exploration

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Carrasquillo, Robyn L.; Metcalf, Jordan; Peterson, Laurie

2012-01-01

NASA is considering a number of future human space exploration mission concepts. Although detailed requirements and vehicle architectures remain mostly undefined, near-term technology investment decisions need to be guided by the anticipated capabilities needed to enable or enhance the mission concepts. This paper describes a roadmap that NASA has formulated to guide the development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) and enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing, flight-proven state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed. When SOA capabilities fell short of meeting the needs, those "gaps" were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The resulting list of enabling and enhancing capability gaps can be used to guide future ECLSS development. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies needed to enable and enhance exploration may be developed in a manner that synergistically benefits the ISS operational capability, supports Multi-Purpose Crew Vehicle (MPCV) development, and sustains long-term technology investments for longer duration missions. This paper summarizes NASA s ECLSS capability roadmap development process, findings, and recommendation

Probing the structural dynamics of the CRISPR-Cas9 RNA-guided DNA-cleavage system by coarse-grained modeling.

PubMed

Zheng, Wenjun

2017-02-01

In the adaptive immune systems of many bacteria and archaea, the Cas9 endonuclease forms a complex with specific guide/scaffold RNA to identify and cleave complementary target sequences in foreign DNA. This DNA targeting machinery has been exploited in numerous applications of genome editing and transcription control. However, the molecular mechanism of the Cas9 system is still obscure. Recently, high-resolution structures have been solved for Cas9 in different structural forms (e.g., unbound forms, RNA-bound binary complexes, and RNA-DNA-bound tertiary complexes, corresponding to an inactive state, a pre-target-bound state, and a cleavage-competent or product state), which offered key structural insights to the Cas9 mechanism. To further probe the structural dynamics of Cas9 interacting with RNA and DNA at the amino-acid level of details, we have performed systematic coarse-grained modeling using an elastic network model and related analyses. Our normal mode analysis predicted a few key modes of collective motions that capture the observed conformational changes featuring large domain motions triggered by binding of RNA and DNA. Our flexibility analysis identified specific regions with high or low flexibility that coincide with key functional sites (such as DNA/RNA-binding sites, nuclease cleavage sites, and key hinges). We also identified a small set of hotspot residues that control the energetics of functional motions, which overlap with known functional sites and offer promising targets for future mutagenesis efforts to improve the specificity of Cas9. Finally, we modeled the conformational transitions of Cas9 from the unbound form to the binary complex and then the tertiary complex, and predicted a distinct sequence of domain motions. In sum, our findings have offered rich structural and dynamic details relevant to the Cas9 machinery, and will guide future investigation and engineering of the Cas9 systems. Proteins 2017; 85:342-353. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

MMI: Increasing Community Collaboration

NASA Astrophysics Data System (ADS)

Galbraith, N. R.; Stocks, K.; Neiswender, C.; Maffei, A.; Bermudez, L.

2007-12-01

Building community requires a collaborative environment and guidance to help move members towards a common goal. An effective environment for community collaboration is a workspace that fosters participation and cooperation; effective guidance furthers common understanding and promotes best practices. The Marine Metadata Interoperability (MMI) project has developed a community web site to provide a collaborative environment for scientists, technologists, and data managers from around the world to learn about metadata and exchange ideas. Workshops, demonstration projects, and presentations also provide community-building opportunities for MMI. MMI has developed comprehensive online guides to help users understand and work with metadata standards, ontologies, and other controlled vocabularies. Documents such as "The Importance of Metadata Standards", "Usage vs. Discovery Vocabularies" and "Developing Controlled Vocabularies" guide scientists and data managers through a variety of metadata-related concepts. Members from eight organizations involved in marine science and informatics collaborated on this effort. The MMI web site has moved from Plone to Drupal, two content management systems which provide different opportunities for community-based work. Drupal's "organic groups" feature will be used to provide workspace for future teams tasked with content development, outreach, and other MMI mission-critical work. The new site is designed to enable members to easily create working areas, to build communities dedicated to developing consensus on metadata and other interoperability issues. Controlled-vocabulary-driven menus, integrated mailing-lists, member-based content creation and review tools are facets of the new web site architecture. This move provided the challenge of developing a hierarchical vocabulary to describe the resources presented on the site; consistent and logical tagging of web pages is the basis of Drupal site navigation. The new MMI web site presents enhanced opportunities for electronic discussions, focused collaborative work, and even greater community participation. The MMI project is beginning a new initiative to comprehensively catalog and document tools for marine metadata. The new MMI community-based web site will be used to support this work and to support the work of other ad-hoc teams in the future. We are seeking broad input from the community on this effort.

Country ownership and capacity building: the next buzzwords in health systems strengthening or a truly new approach to development?

PubMed Central

2012-01-01

Background During the last decade, donor governments and international agencies have increasingly emphasized the importance of building the capacity of indigenous health care organizations as part of strengthening health systems and ensuring sustainability. In 2009, the U.S. Global Health Initiative made country ownership and capacity building keystones of U.S. health development assistance, and yet there is still a lack of consensus on how to define either of these terms, or how to implement “country owned capacity building”. Discussion Concepts around capacity building have been well developed in the for-profit business sector, but remain less well defined in the non-profit and social sectors in low and middle-income countries. Historically, capacity building in developing countries has been externally driven, related to project implementation, and often resulted in disempowerment of local organizations rather than local ownership. Despite the expenditure of millions of dollars, there is no consensus on how to conduct capacity building, nor have there been rigorous evaluations of capacity building efforts. To shift to a new paradigm of country owned capacity building, donor assistance needs to be inclusive in the planning process and create true partnerships to conduct organizational assessments, analyze challenges to organizational success, prioritize addressing challenges, and implement appropriate activities to build new capacity in overcoming challenges. Before further investments are made, a solid evidence base should be established concerning what works and what doesn’t work to build capacity. Summary Country-owned capacity building is a relatively new concept that requires further theoretical exploration. Documents such as The Paris Declaration on Aid Effectiveness detail the principles of country ownership to which partner and donor countries should commit, but do not identify the specific mechanisms to carry out these principles. More evidence as to how country-owned capacity building plays out in practice is needed to guide future interventions. The Global Health Initiative funding that is currently underway is an opportunity to collect evaluative data and establish a centralized and comprehensive evidence base that could be made available to guide future country-owned capacity building efforts. PMID:22818046

Country ownership and capacity building: the next buzzwords in health systems strengthening or a truly new approach to development?

PubMed

Goldberg, Jessica; Bryant, Malcolm

2012-07-20

During the last decade, donor governments and international agencies have increasingly emphasized the importance of building the capacity of indigenous health care organizations as part of strengthening health systems and ensuring sustainability. In 2009, the U.S. Global Health Initiative made country ownership and capacity building keystones of U.S. health development assistance, and yet there is still a lack of consensus on how to define either of these terms, or how to implement "country owned capacity building". Concepts around capacity building have been well developed in the for-profit business sector, but remain less well defined in the non-profit and social sectors in low and middle-income countries. Historically, capacity building in developing countries has been externally driven, related to project implementation, and often resulted in disempowerment of local organizations rather than local ownership. Despite the expenditure of millions of dollars, there is no consensus on how to conduct capacity building, nor have there been rigorous evaluations of capacity building efforts. To shift to a new paradigm of country owned capacity building, donor assistance needs to be inclusive in the planning process and create true partnerships to conduct organizational assessments, analyze challenges to organizational success, prioritize addressing challenges, and implement appropriate activities to build new capacity in overcoming challenges. Before further investments are made, a solid evidence base should be established concerning what works and what doesn't work to build capacity. Country-owned capacity building is a relatively new concept that requires further theoretical exploration. Documents such as The Paris Declaration on Aid Effectiveness detail the principles of country ownership to which partner and donor countries should commit, but do not identify the specific mechanisms to carry out these principles. More evidence as to how country-owned capacity building plays out in practice is needed to guide future interventions. The Global Health Initiative funding that is currently underway is an opportunity to collect evaluative data and establish a centralized and comprehensive evidence base that could be made available to guide future country-owned capacity building efforts.

Rx Articulation. A Guidebook to Successful Curriculum Articulation.

ERIC Educational Resources Information Center

Epps, Irvine

This procedural guide is designed for program operators and service providers who are cognizant of the potential advantages of articulation and are interested in beginning or expanding articulation efforts. The guide's first section explains the various forms of articulation and reviews briefly benefits and barriers. Other sections introduce the…

WWC Study Review Guide: Group Design Studies

ERIC Educational Resources Information Center

What Works Clearinghouse, 2018

2018-01-01

Underlying all What Works Clearinghouse (WWC) products are WWC Study Review Guides, which are intended for use by WWC certified reviewers to assess studies against the WWC evidence standards. As part of an ongoing effort to increase transparency, promote collaboration, and encourage widespread use of the WWC standards, the Institute of Education…

Planning Guide for Implementing a Quality Youth Apprenticeship Program in Georgia.

ERIC Educational Resources Information Center

Smith, Clifton L.

This planning guide begins with an overview of school-to-work transition. Section 1 also provides an overview of federal and Georgia state legislation and describes current school-to-work transition efforts, such as tech prep education, youth apprenticeship, cooperative education, entrepreneurial ventures and school-based enterprises,…

Education for Business in Iowa: Curriculum and Reference Guide.

ERIC Educational Resources Information Center

Iowa State Dept. of Public Instruction, Des Moines.

In recognition of the need to strengthen schools' efforts in developing students' awareness of the technological, consumer, occupational, recreational, and cultural aspects of business, this guide was compiled to provide information assisting those who design and implement curricula relating to business. The first division consists of statements…

Consumer-Business Days; Community-Wide Program. Project Guide No. 101.

ERIC Educational Resources Information Center

New York State Dept. of Commerce, Albany. Woman's Program.

The project guide describes the organization and implementation of consumer-business days, a community-wide business effort in a concentrated period of time (one week to one month) in which: (1) manufacturers; retailers; and financial, trade, and service organizations provide information, literature, tours, clinics, and programs for local…

NWTC Helps Guide U.S. Offshore R&D; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2015-07-01

The National Wind Technology Center (NWTC) at the National Renewable Energy Laboratory (NREL) is helping guide our nation's research-and-development effort in offshore renewable energy, which includes: Design, modeling, and analysis tools; Device and component testing; Resource characterization; Economic modeling and analysis; Grid integration.

Students' Motivation to Learn in Middle School--A Self-Regulated Learning Approach

ERIC Educational Resources Information Center

Paulino, Paula; Sá, Isabel; Lopes da Silva, Adelina

2016-01-01

Introduction: The self-regulation of motivation (SRM) is conceptualized as a meta-motivational process that guides students' efforts and persistence when performing tasks. This process regulates students' behavior through strategies that are influenced by motivational beliefs. SRM allows students to motivate themselves and guides their behavior.…

Summary of performance data for technologies to control gaseous, odor, and particulate emissions from livestock operations: Air management practices assessment tool (AMPAT)

PubMed Central

Maurer, Devin L.; Koziel, Jacek A.; Harmon, Jay D.; Hoff, Steven J.; Rieck-Hinz, Angela M.; Andersen, Daniel S.

2016-01-01

The livestock and poultry production industry, regulatory agencies, and researchers lack a current, science-based guide and data base for evaluation of air quality mitigation technologies. Data collected from science-based review of mitigation technologies using practical, stakeholders-oriented evaluation criteria to identify knowledge gaps/needs and focuses for future research efforts on technologies and areas with the greatest impact potential is presented in the Literature Database tab on the air management practices tool (AMPAT). The AMPAT is web-based (available at www.agronext.iastate.edu/ampat) and provides an objective overview of mitigation practices best suited to address odor, gaseous, and particulate matter (PM) emissions at livestock operations. The data was compiled into Excel spreadsheets from a literature review of 265 papers was performed to (1) evaluate mitigation technologies performance for emissions of odor, volatile organic compounds (VOCs), ammonia (NH3), hydrogen sulfide (H2S), particulate matter (PM), and greenhouse gases (GHGs) and to (2) inform future research needs. PMID:27158660

The National Spallation Neutron Source (NSNS) Project

NASA Astrophysics Data System (ADS)

Appleton, Bill R.

1997-05-01

The need and justification for new sources and instrumentation in neutron science have been firmly established by numerous assessments since the early 1970s by the scientific community and the Department of Energy (DOE). In their 1996 budget, the DOE Office of Energy Research asked ORNL to lead the R&D and conceptual design effort for a next-generation spallation neutron source to be used for neutron scattering. To accomplish this, the NSNS collaboration involving five national laboratories (ANL, BNL, LANL, LBNL, and ORNL) has been formed. The NSNS reference design is for a 1-GeV linac and accumulator ring that delivers 1-MW proton beams in microsend pulses to a mercuty target; neutrons are produced by the spallation reaction, moderated, and guided into an experimental hall for neutron scattering. The design includes the necessary flexibility to upgrade the source in stages to significantly higher powers in the future and to expand the experimental capabilities. This talk will describe the origins at NSNS, the current funding status, progress on the technical design, user community input and the intended uses, and future prospects.

Infusing Quantitative Approaches throughout the Biological Sciences Curriculum

ERIC Educational Resources Information Center

Thompson, Katerina V.; Cooke, Todd J.; Fagan, William F.; Gulick, Denny; Levy, Doron; Nelson, Kären C.; Redish, Edward F.; Smith, Robert F.; Presson, Joelle

2013-01-01

A major curriculum redesign effort at the University of Maryland is infusing all levels of our undergraduate biological sciences curriculum with increased emphasis on interdisciplinary connections and quantitative approaches. The curriculum development efforts have largely been guided by recommendations in the National Research Council's "Bio…

Road weather information system environmental sensor station siting guide, version 2.0

DOT National Transportation Integrated Search

2008-11-01

FHWA initiated an effort in 2007 to evaluate and update, as necessary the ESS Guidelines first published in 2004 (FHWA-HOP-05-026). This effort is summarized in a companion report Implementation and Evaluation of RWIS ESS Siting Guidelines. The...

EMPTAC (Electromagnetic Pulse Test Aircraft) user's guide

NASA Astrophysics Data System (ADS)

Cleaveland, Dale R.; Burkhard, Avery

1988-04-01

This guide was established to give test managers a way to familiarize themselves with the Air Force Weapons Laboratory's electromagnetic pulse (EMP) test aircraft program located at Kirtland Air Force Base (KAFB), New Mexico. Brief descriptions of the available EMP test facilities at KAFB are also included. This guide should give prospective customers (users) adequate information to scope the magnitude of their test effort and to accomplish general planning without extensive involvement in test execution details.

SPIRE, the ``Spin Triangle'': Athens, Hamburg, Buenos Aires: Advancing Nanospintronics and Nanomagnetism

NASA Astrophysics Data System (ADS)

Smith, Arthur R.

2012-02-01

Future technological advances at the frontier of `elec'tronics will increasingly rely on the use of the spin property of the electron at ever smaller length scales. As a result, it is critical to make substantial efforts towards understanding and ultimately controlling spin and magnetism at the nanoscale. In SPIRE, the goal is to achieve these important scientific advancements through a unique combination of experimental and theoretical techniques, as well as complementary expertise and coherent efforts across three continents. The key experimental tool of choice is spin-polarized scanning tunneling microscopy -- the premier method for accessing the spin structure of surfaces and nanostructures with resolution down to the atomic scale. At the same time, atom and molecule deposition and manipulation schemes are added in order to both atomically engineer, and precisely investigate, novel nanoscale spin structures. These efforts are being applied to an array of physical systems, including single magnetic atomic layers, self-assembled 2-D molecular arrays, single adatoms and molecules, and alloyed spintronic materials. Efforts are aimed at exploring complex spin structures and phenomena occurring in these systems. At the same time, the problems are approached, and in some cases guided, by the use of leading theoretical tools, including analytical approaches such as renormalization group theory, and computational approaches such as first principles density functional theory. The scientific goals of the project are achieved by a collaborative effort with the international partners, engaging students at all levels who, through their research experiences both at home and abroad, gain international research outlooks as well as understandings of cultural differences, by working on intriguing problems of mutual interest. A novel scientific journalism internship program based at Ohio University furthers the project's broader impacts.

TELECOM 2000: An Exploration of the Long-Term Development of Telecommunications in Australia.

ERIC Educational Resources Information Center

Australian Telecommunications Commission, Melbourne.

This document is intended as a guide to directions in Australia's social, economic, and technical future as related to likely trends in the demand for telecommunication facilities in the early Twenty-First Century. From this exploration of the future of telecommunications, nine policy recommendations were made to guide telecommunication research,…

Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.

PubMed

Fowler, Christie D; Gipson, Cassandra D; Kleykamp, Bethea A; Rupprecht, Laura E; Harrell, Paul T; Rees, Vaughan W; Gould, Thomas J; Oliver, Jason; Bagdas, Deniz; Damaj, M Imad; Schmidt, Heath D; Duncan, Alexander; De Biasi, Mariella

2018-06-07

Scientific discoveries over the past few decades have provided significant insight into the abuse liability and negative health consequences associated with tobacco and nicotine-containing products. While many of these advances have led to the development of policies and laws that regulate access to and formulations of these products, further research is critical to guide future regulatory efforts, especially as novel nicotine-containing products are introduced and selectively marketed to vulnerable populations. In this narrative review, we provide an overview of the scientific findings that have impacted regulatory policy and discuss considerations for further translation of science into policy decisions. We propose that open, bidirectional communication between scientists and policy makers is essential to develop transformative preventive- and intervention-focused policies and programs to reduce appeal, abuse liability, and toxicity of the products. Through these types of interactions, collaborative efforts to inform and modify policy have the potential to significantly decrease the use of tobacco and alternative nicotine products and thus enhance health outcomes for individuals. This work addresses current topics in the nicotine and tobacco research field to emphasize the importance of basic science research and provide examples of how it can be utilized to inform public policy. In addition to relaying current thoughts on the topic from experts in the field, the article encourages continued efforts and communication between basic scientists and policy officials.

Principles for Predicting RNA Secondary Structure Design Difficulty.

PubMed

Anderson-Lee, Jeff; Fisker, Eli; Kosaraju, Vineet; Wu, Michelle; Kong, Justin; Lee, Jeehyung; Lee, Minjae; Zada, Mathew; Treuille, Adrien; Das, Rhiju

2016-02-27

Designing RNAs that form specific secondary structures is enabling better understanding and control of living systems through RNA-guided silencing, genome editing and protein organization. Little is known, however, about which RNA secondary structures might be tractable for downstream sequence design, increasing the time and expense of design efforts due to inefficient secondary structure choices. Here, we present insights into specific structural features that increase the difficulty of finding sequences that fold into a target RNA secondary structure, summarizing the design efforts of tens of thousands of human participants and three automated algorithms (RNAInverse, INFO-RNA and RNA-SSD) in the Eterna massive open laboratory. Subsequent tests through three independent RNA design algorithms (NUPACK, DSS-Opt and MODENA) confirmed the hypothesized importance of several features in determining design difficulty, including sequence length, mean stem length, symmetry and specific difficult-to-design motifs such as zigzags. Based on these results, we have compiled an Eterna100 benchmark of 100 secondary structure design challenges that span a large range in design difficulty to help test future efforts. Our in silico results suggest new routes for improving computational RNA design methods and for extending these insights to assess "designability" of single RNA structures, as well as of switches for in vitro and in vivo applications. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Teens Working: Turning Earning into Learning. Facilitator Guide [and] Critical Workplace Issues [and] Student Guide.

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR. Education, Career, and Community Program.

These guides are part of a toolkit designed to help young people make connections between the jobs they now hold, the classes they are taking, and the goals they may have for the near and distant future. The guides contain a variety of materials and activities appropriate for all skill levels. The activities in the student guide are grounded in…

Fox Valley Technical Institute Economic Development Plan.

ERIC Educational Resources Information Center

Fox Valley Technical Inst., Appleton, WI.

Designed as an operating blueprint for Fox Valley Technical Institute's (FVTI's) economic development efforts, this guide incorporates the necessary operation procedures, descriptions, and resources for those involved in FVTI's effort to assist existing businesses to expand and to attract new businesses to the area. Introductory material describes…

Covert rapid action-memory simulation (CRAMS): a hypothesis of hippocampal-prefrontal interactions for adaptive behavior.

PubMed

Wang, Jane X; Cohen, Neal J; Voss, Joel L

2015-01-01

Effective choices generally require memory, yet little is known regarding the cognitive or neural mechanisms that allow memory to influence choices. We outline a new framework proposing that covert memory processing of hippocampus interacts with action-generation processing of prefrontal cortex in order to arrive at optimal, memory-guided choices. Covert, rapid action-memory simulation (CRAMS) is proposed here as a framework for understanding cognitive and/or behavioral choices, whereby prefrontal-hippocampal interactions quickly provide multiple simulations of potential outcomes used to evaluate the set of possible choices. We hypothesize that this CRAMS process is automatic, obligatory, and covert, meaning that many cycles of action-memory simulation occur in response to choice conflict without an individual's necessary intention and generally without awareness of the simulations, leading to adaptive behavior with little perceived effort. CRAMS is thus distinct from influential proposals that adaptive memory-based behavior in humans requires consciously experienced memory-based construction of possible future scenarios and deliberate decisions among possible future constructions. CRAMS provides an account of why hippocampus has been shown to make critical contributions to the short-term control of behavior, and it motivates several new experimental approaches and hypotheses that could be used to better understand the ubiquitous role of prefrontal-hippocampal interactions in situations that require adaptively using memory to guide choices. Importantly, this framework provides a perspective that allows for testing decision-making mechanisms in a manner that translates well across human and nonhuman animal model systems. Copyright © 2014 Elsevier Inc. All rights reserved.

EMF Rapid Program Engineering Projects, Project 1, Development of Recommendations for Guidelines for Field Source Measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Electric Research and Management, Inc.

1997-03-11

The goal of this project is to develop a protocol for measuring the electric and magnetic fields around sources. Data from these measurements may help direct future biological effects research by better defining the complexity of magnetic and electric fields to which humanity is exposed, as well asprovide the basis for rigorous field exposure analysis and risk assessment once the relationship between field exposure and biological response. is better understood. The data base also should have sufficient spatial and temporal characteristics to guide electric and magnetic field management. The goal of Task A is to construct a set of characteristicsmore » that would be ideal to have for guiding and interpreting biological studies and for focusing any future effort at field management. This ideal set will then be quantified and reduced according to the availability (or possible development of) instrumentation to measure the desired characteristics. Factors that also will be used to define pragmatic data sets will be the cost of collecting the data, the cost of developing an adequate data base, and the needed precision in measuring specific characteristics. A field, electric or magnetic, will always be ,some function of time and space. The first step in this section of the protocol development will be to determine what span of time and what portion of space are required to quantify the electric and magnetic fields around sources such as appliances and electrical apparatus. Constraints on time will be set by examining measurement limitations and biological data requirements.« less

Unblinding the dark matter blind spots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, Tao; Kling, Felix; Su, Shufang

The dark matter (DM) blind spots in the Minimal Supersymmetric Standard Model (MSSM) refer to the parameter regions where the couplings of the DM particles to the $Z$-boson or the Higgs boson are almost zero, leading to vanishingly small signals for the DM direct detections. In this paper, we carry out comprehensive analyses for the DM searches under the blind-spot scenarios in MSSM. Guided by the requirement of acceptable DM relic abundance, we explore the complementary coverage for the theory parameters at the LHC, the projection for the future underground DM direct searches, and the indirect searches from the relicmore » DM annihilation into photons and neutrinos. We find that (i) the spin-independent (SI) blind spots may be rescued by the spin-dependent (SD) direct detection in the future underground experiments, and possibly by the indirect DM detections from IceCube and SuperK neutrino experiments; (ii) the detection of gamma rays from Fermi-LAT may not reach the desirable sensitivity for searching for the DM blind-spot regions; (iii) the SUSY searches at the LHC will substantially extend the discovery region for the blind-spot parameters. As a result, the dark matter blind spots thus may be unblinded with the collective efforts in future DM searches.« less

The past, present, and future of U.S. utility demand-side management programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eto, J.

Demand-side management or DSM refers to active efforts by electric and gas utilities to modify customers` energy use patterns. The experience in the US shows that utilities, when provided with appropriate incentives, can provide a powerful stimulus to energy efficiency in the private sector. This paper describes the range and history of DSM programs offered by US electric utilities, with a focus on the political, economic, and regulatory events that have shaped their evolution. It also describes the changes these programs are undergoing as a result of US electricity industry restructuring. DSM programs began modestly in the 1970s in responsemore » to growing concerns about dependence on foreign sources of oil and environmental consequences of electricity generation, especially nuclear power. The foundation for the unique US partnership between government and utility interests can be traced first to the private-ownership structure of the vertically integrated electricity industry and second to the monopoly franchise granted by state regulators. Electricity industry restructuring calls into question both of these basic conditions, and thus the future of utility DSM programs for the public interest. Future policies guiding ratepayer-funded energy-efficiency DSM programs will need to pay close attention to the specific market objectives of the programs and to the balance between public and private interests.« less

Unblinding the dark matter blind spots

DOE PAGES

Han, Tao; Kling, Felix; Su, Shufang; ...

2017-02-10

The dark matter (DM) blind spots in the Minimal Supersymmetric Standard Model (MSSM) refer to the parameter regions where the couplings of the DM particles to the $Z$-boson or the Higgs boson are almost zero, leading to vanishingly small signals for the DM direct detections. In this paper, we carry out comprehensive analyses for the DM searches under the blind-spot scenarios in MSSM. Guided by the requirement of acceptable DM relic abundance, we explore the complementary coverage for the theory parameters at the LHC, the projection for the future underground DM direct searches, and the indirect searches from the relicmore » DM annihilation into photons and neutrinos. We find that (i) the spin-independent (SI) blind spots may be rescued by the spin-dependent (SD) direct detection in the future underground experiments, and possibly by the indirect DM detections from IceCube and SuperK neutrino experiments; (ii) the detection of gamma rays from Fermi-LAT may not reach the desirable sensitivity for searching for the DM blind-spot regions; (iii) the SUSY searches at the LHC will substantially extend the discovery region for the blind-spot parameters. As a result, the dark matter blind spots thus may be unblinded with the collective efforts in future DM searches.« less

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

PubMed Central

Rocha-Gaso, María-Isabel; March-Iborra, Carmen; Montoya-Baides, Ángel; Arnau-Vives, Antonio

2009-01-01

This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices - Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) - have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this work is to describe the state-of-the-art of SGAW biosensors for the detection of pathogens, being this topic an issue of extremely importance for the human health. Finally, the review discuses the commercial availability, trends and future challenges of the SGAW biosensors for such applications. PMID:22346725

The future of pediatric dentistry education and curricula: a Chilean perspective.

PubMed

Mariño, Rodrigo; Ramos-Gómez, Francisco; Manton, David John; Onetto, Juan Eduardo; Hugo, Fernando; Feldens, Carlos Alberto; Bedi, Raman; Uribe, Sergio; Zillmann, Gisela

2016-07-18

A meeting was organised to consolidate a network of researchers and academics from Australia, Brazil, Chile, the UK and the USA, relating to Early Childhood Caries (ECC) and Dental Trauma (DT). As part of this meeting, a dedicated session was held on the future of paediatric dental education and curricula. Twenty-four paediatric dentistry (PD) academics, representing eight Chilean dental schools, and three international specialists (from Brazil and Latvia) participated in group discussions facilitated by five members of the ECC/DT International Collaborative Network. Data were collected from group discussions which followed themes developed as guides to identify key issues associated with paediatric dentistry education, training and research. Participants discussed current PD dental curricula in Chile, experiences in educating new cohorts of oral health care providers, and the outcomes of existing efforts in education and research in PD. They also, identified challenges, opportunities and areas in need of further development. This paper provides an introspective analysis of the education and training of PD in Chile; describes the input provided by participants into pediatric dentistry education and curricula; and sets out some key priorities for action with suggested directions to best prepare the future dental workforce to maximise oral health outcomes for children. Immediate priorities for action in paediatric dentistry in Chile were proposed.

Organizational Health Literacy: Review of Theories, Frameworks, Guides, and Implementation Issues

PubMed Central

Bonneville, Luc; Bouchard, Louise

2018-01-01

Organizational health literacy is described as an organization-wide effort to transform organization and delivery of care and services to make it easier for people to navigate, understand, and use information and services to take care of their health. Several health literacy guides have been developed to assist healthcare organizations with this effort, but their content has not been systematically reviewed to understand the scope and practical implications of this transformation. The objective of this study was to review (1) theories and frameworks that inform the concept of organizational health literacy, (2) the attributes of organizational health literacy as described in the guides, (3) the evidence for the effectiveness of the guides, and (4) the barriers and facilitators to implementing organizational health literacy. Drawing on a metanarrative review method, 48 publications were reviewed, of which 15 dealt with the theories and operational frameworks, 20 presented health literacy guides, and 13 addressed guided implementation of organizational health literacy. Seven theories and 9 operational frameworks have been identified. Six health literacy dimensions and 9 quality-improvement characteristics were reviewed for each health literacy guide. Evidence about the effectiveness of health literacy guides is limited at this time, but experiences with the guides were positive. Thirteen key barriers (conceived also as facilitators) were identified. Further development of organizational health literacy requires a strong and a clear connection between its vision and operationalization as an implementation strategy to patient-centered care. For many organizations, becoming health literate will require multiple, simultaneous, and radical changes. Organizational health literacy has to make sense from clinical and financial perspectives in order for organizations to embark on such transformative journey. PMID:29569968

Organizational Health Literacy: Review of Theories, Frameworks, Guides, and Implementation Issues.

PubMed

Farmanova, Elina; Bonneville, Luc; Bouchard, Louise

2018-01-01

Organizational health literacy is described as an organization-wide effort to transform organization and delivery of care and services to make it easier for people to navigate, understand, and use information and services to take care of their health. Several health literacy guides have been developed to assist healthcare organizations with this effort, but their content has not been systematically reviewed to understand the scope and practical implications of this transformation. The objective of this study was to review (1) theories and frameworks that inform the concept of organizational health literacy, (2) the attributes of organizational health literacy as described in the guides, (3) the evidence for the effectiveness of the guides, and (4) the barriers and facilitators to implementing organizational health literacy. Drawing on a metanarrative review method, 48 publications were reviewed, of which 15 dealt with the theories and operational frameworks, 20 presented health literacy guides, and 13 addressed guided implementation of organizational health literacy. Seven theories and 9 operational frameworks have been identified. Six health literacy dimensions and 9 quality-improvement characteristics were reviewed for each health literacy guide. Evidence about the effectiveness of health literacy guides is limited at this time, but experiences with the guides were positive. Thirteen key barriers (conceived also as facilitators) were identified. Further development of organizational health literacy requires a strong and a clear connection between its vision and operationalization as an implementation strategy to patient-centered care. For many organizations, becoming health literate will require multiple, simultaneous, and radical changes. Organizational health literacy has to make sense from clinical and financial perspectives in order for organizations to embark on such transformative journey.

Parent Management Training-Oregon Model (PMTO™) in Mexico City: Integrating Cultural Adaptation Activities in an Implementation Model

PubMed Central

Baumann, Ana A.; Domenech Rodríguez, Melanie M.; Amador, Nancy G.; Forgatch, Marion S.; Parra-Cardona, J. Rubén

2015-01-01

This article describes the process of cultural adaptation at the start of the implementation of the Parent Management Training intervention-Oregon model (PMTO) in Mexico City. The implementation process was guided by the model, and the cultural adaptation of PMTO was theoretically guided by the cultural adaptation process (CAP) model. During the process of the adaptation, we uncovered the potential for the CAP to be embedded in the implementation process, taking into account broader training and economic challenges and opportunities. We discuss how cultural adaptation and implementation processes are inextricably linked and iterative and how maintaining a collaborative relationship with the treatment developer has guided our work and has helped expand our research efforts, and how building human capital to implement PMTO in Mexico supported the implementation efforts of PMTO in other places in the United States. PMID:26052184

Parent Management Training-Oregon Model (PMTO™) in Mexico City: Integrating Cultural Adaptation Activities in an Implementation Model.

PubMed

Baumann, Ana A; Domenech Rodríguez, Melanie M; Amador, Nancy G; Forgatch, Marion S; Parra-Cardona, J Rubén

2014-03-01

This article describes the process of cultural adaptation at the start of the implementation of the Parent Management Training intervention-Oregon model (PMTO) in Mexico City. The implementation process was guided by the model, and the cultural adaptation of PMTO was theoretically guided by the cultural adaptation process (CAP) model. During the process of the adaptation, we uncovered the potential for the CAP to be embedded in the implementation process, taking into account broader training and economic challenges and opportunities. We discuss how cultural adaptation and implementation processes are inextricably linked and iterative and how maintaining a collaborative relationship with the treatment developer has guided our work and has helped expand our research efforts, and how building human capital to implement PMTO in Mexico supported the implementation efforts of PMTO in other places in the United States.

Piot: U.S. should play greater role in global effort.

PubMed

1999-11-26

UNAIDS executive director Peter Piot called for the United States to do more to support HIV prevention efforts internationally. Speaking at the United States Conference on AIDS, he said that U.S. groups will need to offer more technical assistance and advice to community-based organizations around the world if they ever hope to manage the epidemic. UNAIDS will issue model legislation which other countries can use to pattern their own anti-discrimination laws. Health Canada recently published a guide in which ways that community-based organizations in industrialized countries can assist their counterparts in the developing world are outlined. Information is included for ordering the guide.

Environmental Stewardship: A Conceptual Review and Analytical Framework.

PubMed

Bennett, Nathan J; Whitty, Tara S; Finkbeiner, Elena; Pittman, Jeremy; Bassett, Hannah; Gelcich, Stefan; Allison, Edward H

2018-04-01

There has been increasing attention to and investment in local environmental stewardship in conservation and environmental management policies and programs globally. Yet environmental stewardship has not received adequate conceptual attention. Establishing a clear definition and comprehensive analytical framework could strengthen our ability to understand the factors that lead to the success or failure of environmental stewardship in different contexts and how to most effectively support and enable local efforts. Here we propose such a definition and framework. First, we define local environmental stewardship as the actions taken by individuals, groups or networks of actors, with various motivations and levels of capacity, to protect, care for or responsibly use the environment in pursuit of environmental and/or social outcomes in diverse social-ecological contexts. Next, drawing from a review of the environmental stewardship, management and governance literatures, we unpack the elements of this definition to develop an analytical framework that can facilitate research on local environmental stewardship. Finally, we discuss potential interventions and leverage points for promoting or supporting local stewardship and future applications of the framework to guide descriptive, evaluative, prescriptive or systematic analysis of environmental stewardship. Further application of this framework in diverse environmental and social contexts is recommended to refine the elements and develop insights that will guide and improve the outcomes of environmental stewardship initiatives and investments. Ultimately, our aim is to raise the profile of environmental stewardship as a valuable and holistic concept for guiding productive and sustained relationships with the environment.

Environmental Stewardship: A Conceptual Review and Analytical Framework

NASA Astrophysics Data System (ADS)

Bennett, Nathan J.; Whitty, Tara S.; Finkbeiner, Elena; Pittman, Jeremy; Bassett, Hannah; Gelcich, Stefan; Allison, Edward H.

2018-04-01

There has been increasing attention to and investment in local environmental stewardship in conservation and environmental management policies and programs globally. Yet environmental stewardship has not received adequate conceptual attention. Establishing a clear definition and comprehensive analytical framework could strengthen our ability to understand the factors that lead to the success or failure of environmental stewardship in different contexts and how to most effectively support and enable local efforts. Here we propose such a definition and framework. First, we define local environmental stewardship as the actions taken by individuals, groups or networks of actors, with various motivations and levels of capacity, to protect, care for or responsibly use the environment in pursuit of environmental and/or social outcomes in diverse social-ecological contexts. Next, drawing from a review of the environmental stewardship, management and governance literatures, we unpack the elements of this definition to develop an analytical framework that can facilitate research on local environmental stewardship. Finally, we discuss potential interventions and leverage points for promoting or supporting local stewardship and future applications of the framework to guide descriptive, evaluative, prescriptive or systematic analysis of environmental stewardship. Further application of this framework in diverse environmental and social contexts is recommended to refine the elements and develop insights that will guide and improve the outcomes of environmental stewardship initiatives and investments. Ultimately, our aim is to raise the profile of environmental stewardship as a valuable and holistic concept for guiding productive and sustained relationships with the environment.

Husbandry of wild-caught song sparrows (Melospiza melodia).

PubMed

Smith, Lori; Hallager, Sara; Kendrick, Erin; Hope, Katharine; Danner, Raymond M

2018-05-08

Conservation and research efforts occasionally rely upon bringing wild animals into human care to establish breeding programs and to understand their biology. Wild-caught birds may have husbandry requirements that differ from captive-reared animals due, in part, to their social development in the wild and potential exposure to novel pathogens. We developed husbandry techniques to minimize stress and monitor health in a population of wild-caught song sparrows (Melospiza melodia). We describe enclosure conditions, diet and enrichment, and best practices for stress reduction. In addition, we describe several health monitoring strategies, including assessing feces quality, body condition scores, and specific signs of infection. These techniques led to successful housing of song sparrows during formal behavioral and developmental studies. This information will be useful for guiding the husbandry of wild-caught passerine birds in the future. © 2018 Wiley Periodicals, Inc.

Identifying structural elements needed for development of a predictive life-history model for pallid and shovelnose sturgeons

USGS Publications Warehouse

Wildhaber, Mark L.; DeLonay, A.J.; Papoulias, D.M.; Galat, D.L.; Jacobson, R.B.; Simpkins, D.G.; Braaten, P.J.; Korschgen, C.E.; Mac, M.J.

2011-01-01

Intensive management of the Missouri and Mississippi Rivers has resulted in dramatic changes to the river systems and their biota. These changes have been implicated in the decline of the pallid sturgeon (Scaphirhynchus albus), which has been listed as a United States federal endangered species. The sympatric shovelnose sturgeon (S. platorynchus) is more common and widespread but has also been in decline. The decline of pallid sturgeon is considered symptomatic of poor reproductive success and low or no recruitment. In order to organize information about these species and provide a basis for future development of a predictive model to help guide recovery efforts, we present an expert-vetted, conceptual life-history framework that incorporates the factors that affect reproduction, growth, and survival of shovelnose and pallid sturgeons.

Simulated annealing in orbital flight planning

NASA Technical Reports Server (NTRS)

Soller, Jeffrey

1990-01-01

Simulated annealing is used to solve a minimum fuel trajectory problem in the space station environment. The environment is unique because the space station will define the first true multivehicle environment in space. The optimization yields surfaces which are potentially complex, with multiple local minima. Because of the likelihood of these local minima, descent techniques are unable to offer robust solutions. Other deterministic optimization techniques were explored without success. The simulated annealing optimization is capable of identifying a minimum-fuel, two-burn trajectory subject to four constraints. Furthermore, the computational efforts involved in the optimization are such that missions could be planned on board the space station. Potential applications could include the on-site planning of rendezvous with a target craft of the emergency rescue of an astronaut. Future research will include multiwaypoint maneuvers, using a knowledge base to guide the optimization.

Structural and electronic properties of Ga2O3-Al2O3 alloys

NASA Astrophysics Data System (ADS)

Peelaers, Hartwin; Varley, Joel B.; Speck, James S.; Van de Walle, Chris G.

2018-06-01

Ga2O3 is emerging as an important electronic material. Alloying with Al2O3 is a viable method to achieve carrier confinement, to increase the bandgap, or to modify the lattice parameters. However, the two materials have very different ground-state crystal structures (monoclinic β-gallia for Ga2O3 and corundum for Al2O3). Here, we use hybrid density functional theory calculations to assess the alloy stabilities and electronic properties of the alloys. We find that the monoclinic phase is the preferred structure for up to 71% Al incorporation, in close agreement with experimental phase diagrams, and that the ordered monoclinic AlGaO3 alloy is exceptionally stable. We also discuss bandgap bowing, lattice constants, and band offsets that can guide future synthesis and device design efforts.

A Brief Report on the Ethical and Legal Guides For Technology Use in Marriage and Family Therapy.

PubMed

Pennington, Michael; Patton, Rikki; Ray, Amber; Katafiasz, Heather

2017-10-01

Marriage and family therapists (MFTs) use ethical codes and state licensure laws/rules as guidelines for best clinical practice. It is important that professional codes reflect the potential exponential use of technology in therapy. However, current standards regarding technology use lack clarity. To explore this gap, a summative content analysis was conducted on state licensure laws/rules and professional ethical codes to find themes and subthemes among the many aspects of therapy in which technology can be utilized. Findings from the content analysis indicated that while there have been efforts by both state and professional organizations to incorporate guidance for technology use in therapy, a clear and comprehensive "roadmap" is still missing. Future scholarship is needed that develops clearer guidelines for therapists. © 2017 American Association for Marriage and Family Therapy.

Building a science of partnership-focused research: forging and sustaining partnerships to support child mental health prevention and services research.

PubMed

Bradshaw, Catherine P; Haynes, Katherine Taylor

2012-07-01

Building on growing interest in translational research, this paper provides an overview of a special issue of Administration and Policy in Mental Health and Mental Health Service Research, which is focused on the process of forging and sustaining partnerships to support child mental health prevention and services research. We propose that partnership-focused research is a subdiscipline of translational research which requires additional research to better refine the theoretical framework and the core principles that will guide future research and training efforts. We summarize some of the major themes across the eight original articles and three commentaries included in the special issue. By advancing the science of partnership-focused research we will be able to bridge the gap between child mental health prevention and services research and practice.

Work-Related Learning Guide for Family Literacy and Adult Education Organizations.

ERIC Educational Resources Information Center

Jobs for the Future, Boston, MA.

This guide assists family literacy and adult education organizations considering ways in which work and learning can be integrated in their educational programs. Part I addresses influences motivating the family literacy and adult education fields to incorporate work-related learning into their efforts. Part II provides a framework for designing…

Career Pathways Skill-Building Activities Guide.

ERIC Educational Resources Information Center

Community Coll. of Rhode Island, Warwick.

In an effort to relate academic skills with workplace skills and facilitate the transition from school to work, the Community College of Rhode Island developed a skill-based instructional model targeted at 9th through 12th graders and consisting of 6 instructional areas, or strands, and 31 related skills. This guide provides suggested activities…

Promoting, Guiding, and Surviving Change in School Districts.

ERIC Educational Resources Information Center

Deal, Terrence E.; Nutt, Samuel C.

Compiled for school administrators who must initiate or respond to external mandate for change, this guide draws on the experiences of 10 rural school districts that participated in the federally funded Experimental Schools (ES) program for perspectives that can be used in the successful management of change efforts in school districts. Organized…

Community Education Parenting Resource Guide. Bulletin 1982, No. 5.

ERIC Educational Resources Information Center

Bradwell, John; And Others

Designed for use by community education coordinators, elementary classroom teachers, PTA workers, school volunteers, and parents, this guide offers suggestions about ways to unite the school and the home in efforts to help children learn. The first section discusses the expanded role of the community education coordinator in parenting programs and…

The Admissions Profession: A Guide for Staff Development and Program Management.

ERIC Educational Resources Information Center

American Association of Collegiate Registrars and Admissions Officers, Washington, DC.

This guide is designed to assist in college admissions staff development and program management, but is also suggested for use in training and accrediting efforts, presentations on admissions tasks, internal or external evaluations, preparation of periodic reports, and as a self-paced workbook when preparing for the admission profession, or for…

Oklahoma Curriculum Guide for Teaching Safety Education.

ERIC Educational Resources Information Center

Oklahoma Curriculum Improvement Commission, Oklahoma City.

Developed by classroom teachers, university professors, and personnel from the Oklahoma State Department of Education, this guide is an effort to assist teachers in locating and utilizing safety materials as well as to assist them in developing well-balanced safety programs for the children and young people in the state. The preschool and…

Tobacco If You Use...You Lose.

ERIC Educational Resources Information Center

Texas State Dept. of Health, Austin.

This teacher's guide was developed to provide essential information that will enable students to make independent and healthy decisions regarding tobacco use. Each lesson in the guide covers both smoking and smokeless tobacco in an effort to add to the realization that all tobacco products have health risks associated with their use and to dispel…

A Guide to Selecting Results and Indicators: Implementing Results-Based Budgeting.

ERIC Educational Resources Information Center

Melaville, Atelia I.

Many efforts to implement a results-based framework for public programs have been marred by confusion about terms and basic definitions, and difficulty in identifying appropriate results and performance measures. This guide is intended to help planners identifying program results and indicators and tie them to an established planning, budgeting,…

Partnerships against Violence: Promising Programs. Volume 1: Resource Guide.

ERIC Educational Resources Information Center

Department of Housing and Urban Development, Washington, DC.

This volume represents the first step in an effort to build a central repository of promising anti-violence programs. Part of a cooperative venture in the federal government, this resource guide draws on information stored in more than 30 Federal clearinghouses and resource centers. Included here are programs developed by government agencies,…

Guide to Working with Model Providers.

ERIC Educational Resources Information Center

Walter, Katie; Hassel, Bryan C.

Often a central feature of a school's improvement efforts is the adoption of a Comprehensive School Reform (CSR) model, an externally developed research-based design for school improvement. Adopting a model is only the first step in CSR. Another important step is forging partnerships with developers of CSR models. This guide aims to help schools…

Colorado State Plan for the Developmentally Disabled: Master Planning Guide for Instructional Objectives. Second Edition.

ERIC Educational Resources Information Center

Shibata, Paul

A product of joint effort between the Colorado Department of Institutions and the Division of Developmental Disabilities, the guide presents hierarchically arranged instructional objectives to determine goals for developmentally disabled persons. The most advanced skills are listed first with basic skills following for four major categories:…

Architivity: Union Station. An Interdisciplinary Guide to Kansas City's Most Monumental Landmark.

ERIC Educational Resources Information Center

Graves, Ginny, Ed.

The American Institute of Architects, locally and nationally, is active in supporting environmental education efforts in the schools. Because of its "endangered" status, Union Station in Kansas City, Missouri, was chosen by the Kansas City chapter as the second focus landmark in the their series. This interdisciplinary field guide serves…

Increasing Reading Compliance and Metacognitive Strategies in Border Students

ERIC Educational Resources Information Center

Culver, Tiffany F.

2016-01-01

In an effort to increase reading compliance and active reading strategies, quizzes and reading guides were given to 100 participants in four psychology courses. Each participant was given four weeks of reading quizzes and four weeks of reading guides. Participants consisted of students (freshman through senior level) from two colleges along the…

Databases post-processing in Tensoral

NASA Technical Reports Server (NTRS)

Dresselhaus, Eliot

1994-01-01

The Center for Turbulent Research (CTR) post-processing effort aims to make turbulence simulations and data more readily and usefully available to the research and industrial communities. The Tensoral language, introduced in this document and currently existing in prototype form, is the foundation of this effort. Tensoral provides a convenient and powerful protocol to connect users who wish to analyze fluids databases with the authors who generate them. In this document we introduce Tensoral and its prototype implementation in the form of a user's guide. This guide focuses on use of Tensoral for post-processing turbulence databases. The corresponding document - the Tensoral 'author's guide' - which focuses on how authors can make databases available to users via the Tensoral system - is currently unwritten. Section 1 of this user's guide defines Tensoral's basic notions: we explain the class of problems at hand and how Tensoral abstracts them. Section 2 defines Tensoral syntax for mathematical expressions. Section 3 shows how these expressions make up Tensoral statements. Section 4 shows how Tensoral statements and expressions are embedded into other computer languages (such as C or Vectoral) to make Tensoral programs. We conclude with a complete example program.

An Evaluation of Evidence-Based Interventions to Increase Compliance among Children with Autism

ERIC Educational Resources Information Center

Fischetti, Anthony T.; Wilder, David A.; Myers, Kristin; Leon-Enriquez, Yanerys; Sinn, Stephanie; Rodriguez, Rebecka

2012-01-01

We evaluated 4 evidence-based interventions to increase compliance. Three children with autism who exhibited noncompliance when asked to relinquish a preferred toy were exposed sequentially to interventions that included a reduction in response effort, differential reinforcement, and guided compliance. Results indicated that effort reduction alone…

School of the Future Handbook. A Guide for Technology Implementation. F. M. Black Middle School.

ERIC Educational Resources Information Center

Smith, Richard Alan; Sassi, Anthony

In 1985, Apple Computer, Inc., and the Houston Independent School District began a project to create a model School of the Future at the F. M. Black Middle School. As described in this guide, the project was designed to demonstrate how microcomputers and related technology can make the process of instruction more efficient and effective. The…

A Policymaker's Guide to Early College Designs: Expanding a Strategy for Achieving College Readiness for All

ERIC Educational Resources Information Center

Hoffman, Nancy; Vargas, Joel

2010-01-01

Today, states and the federal government recognize the potential of early college designs to improve the economic prospects of future generations. But individuals are just beginning to put in place public policies that promote and support early college designs on a significant scale. Jobs for the Future (JFF) prepared this guide to help…

A Framework for Guiding Future Citizens to Think Critically about Nature of Science and Socioscientific Issues

ERIC Educational Resources Information Center

Yacoubian, Hagop A.

2015-01-01

In this article, I introduce a framework for guiding future citizens to think critically about nature of science (NOS) and "with" NOS as they engage in socioscientific decision making. The framework, referred to as the critical thinking--nature of science (CT-NOS) framework, explicates and targets both NOS as a learning objective and NOS…

Fidelity in Models-Based Practice Research in Sport Pedagogy: A Guide for Future Investigations

ERIC Educational Resources Information Center

Hastie, Peter A.; Casey, Ashley

2014-01-01

This paper provides a commentary on research on models-based practice within physical education and presents a tutorial that aims to guide the reporting of future research using pedagogical models. Three key elements are presented that could be considered as essential for inclusion in any methods section in order for readers to gain an accurate…

Survey of nongovernmental organizations providing pediatric cardiovascular care in low- and middle-income countries.

PubMed

Nguyen, Nguyenvu; Jacobs, Jeffrey P; Dearani, Joseph A; Weinstein, Samuel; Novick, William M; Jacobs, Marshall L; Massey, Jeremy; Pasquali, Sara K; Walters, Henry L; Drullinsky, David; Stellin, Giovanni; Tchervenkov, Christo I

2014-04-01

Nearly 90% of the children with heart disease in low- and middle-income countries (LMICs) cannot access cardiovascular (CV) services. Limitations include inadequate financial, human, and infrastructure resources. Nongovernmental organizations (NGOs) have played crucial roles in providing clinical services and infrastructure supports to LMICs CV programs; however, these outreach efforts are dispersed, inadequate, and lack coordination. A survey was sent to members of the World Society for Pediatric and Congenital Heart Society and PediHeart. A clearinghouse was created to provide information on NGO structures, geographic reach, and scope of services. The survey identified 80 NGOs supporting CV programs in 92 LMICs. The largest outreach efforts were in South and Central America (42%), followed by Africa (18%), Europe (17%), Asia (17%), and Asia-Western Pacific (6%). Most NGOs (51%) supported two to five outreach missions per year. The majority (87%) of NGOs provided education, diagnostics, and surgical or catheter-based interventions. Working jointly with LMIC partners, 59% of the NGOs performed operations in children and infants; 41% performed nonbypass neonatal operations. Approximately a quarter (26%) reported that partner sites do not perform interventions in between missions. Disparity and inadequacy in pediatric CV services remain an important problem for LMICs. A global consensus and coordinated efforts are needed to guide strategies on the development of regional centers of excellence, a global outcome database, and a CV program registry. Future efforts should be held accountable for impacts such as growth in the number of independent LMIC programs as well as reduction in mortality and patient waiting lists.

Community Stakeholders' Perceptions of Major Factors Influencing Childhood Obesity, the Feasibility of Programs Addressing Childhood Obesity, and Persisting Gaps.

PubMed

Ganter, Claudia; Aftosmes-Tobio, Alyssa; Chuang, Emmeline; Blaine, Rachel E; Land, Thomas; Davison, Kirsten K

2016-04-01

Prior research has identified numerous factors contributing to increased rates of childhood obesity. However, few studies have focused explicitly on the experience of community stakeholders in low-income communities. This study sought to capture the perspectives of these on-the-ground experts regarding major factors contributing to childhood obesity as well as gaps in current prevention and control efforts. We conducted semi-structured interviews with 39 stakeholders from different community sectors (e.g., healthcare providers, childcare providers, teachers). Data were drawn from the Massachusetts Childhood Obesity Research Demonstration project, a multi-level, multi-sector intervention designed to reduce childhood obesity being implemented in two low-income communities in Massachusetts. Interviews were conducted at baseline, transcribed, coded using grounded theory approach, and analyzed in NVivo 10.0. The vast majority of stakeholders had recently participated in obesity prevention strategies, and nearly all of them identified gaps in prevention efforts either within their organizations or in the broader community. In addition to factors previously identified in the literature, several themes emerged including the need to change policies to increase physical activity during school, offer healthier snacks in schools and afterschool programs, and increase communication and collaboration within the community in prevention efforts. Community stakeholders can impact the success of interventions by bridging the gap between science and lived experience. The results of this study can guide future research by highlighting the importance of including stakeholders' frontline experiences with target populations, and using information on identified gaps to augment intervention planning efforts.

Retrospective View of North American Potato (Solanum tuberosum L.) Breeding in the 20th and 21st Centuries

PubMed Central

Hirsch, Candice N.; Hirsch, Cory D.; Felcher, Kimberly; Coombs, Joseph; Zarka, Dan; Van Deynze, Allen; De Jong, Walter; Veilleux, Richard E.; Jansky, Shelley; Bethke, Paul; Douches, David S.; Buell, C. Robin

2013-01-01

Cultivated potato (Solanum tuberosum L.), a vegetatively propagated autotetraploid, has been bred for distinct market classes, including fresh market, pigmented, and processing varieties. Breeding efforts have relied on phenotypic selection of populations developed from intra- and intermarket class crosses and introgressions of wild and cultivated Solanum relatives. To retrospectively explore the effects of potato breeding at the genome level, we used 8303 single-nucleotide polymorphism markers to genotype a 250-line diversity panel composed of wild species, genetic stocks, and cultivated potato lines with release dates ranging from 1857 to 2011. Population structure analysis revealed four subpopulations within the panel, with cultivated potato lines grouping together and separate from wild species and genetic stocks. With pairwise kinship estimates clear separation between potato market classes was observed. Modern breeding efforts have scarcely changed the percentage of heterozygous loci or the frequency of homozygous, single-dose, and duplex loci on a genome level, despite concerted efforts by breeders. In contrast, clear selection in less than 50 years of breeding was observed for alleles in biosynthetic pathways important for market class-specific traits such as pigmentation and carbohydrate composition. Although improvement and diversification for distinct market classes was observed through whole-genome analysis of historic and current potato lines, an increased rate of gain from selection will be required to meet growing global food demands and challenges due to climate change. Understanding the genetic basis of diversification and trait improvement will allow for more rapid genome-guided improvement of potato in future breeding efforts. PMID:23589519

Retrospective view of North American potato (Solanum tuberosum L.) breeding in the 20th and 21st centuries.

PubMed

Hirsch, Candice N; Hirsch, Cory D; Felcher, Kimberly; Coombs, Joseph; Zarka, Dan; Van Deynze, Allen; De Jong, Walter; Veilleux, Richard E; Jansky, Shelley; Bethke, Paul; Douches, David S; Buell, C Robin

2013-06-21

Cultivated potato (Solanum tuberosum L.), a vegetatively propagated autotetraploid, has been bred for distinct market classes, including fresh market, pigmented, and processing varieties. Breeding efforts have relied on phenotypic selection of populations developed from intra- and intermarket class crosses and introgressions of wild and cultivated Solanum relatives. To retrospectively explore the effects of potato breeding at the genome level, we used 8303 single-nucleotide polymorphism markers to genotype a 250-line diversity panel composed of wild species, genetic stocks, and cultivated potato lines with release dates ranging from 1857 to 2011. Population structure analysis revealed four subpopulations within the panel, with cultivated potato lines grouping together and separate from wild species and genetic stocks. With pairwise kinship estimates clear separation between potato market classes was observed. Modern breeding efforts have scarcely changed the percentage of heterozygous loci or the frequency of homozygous, single-dose, and duplex loci on a genome level, despite concerted efforts by breeders. In contrast, clear selection in less than 50 years of breeding was observed for alleles in biosynthetic pathways important for market class-specific traits such as pigmentation and carbohydrate composition. Although improvement and diversification for distinct market classes was observed through whole-genome analysis of historic and current potato lines, an increased rate of gain from selection will be required to meet growing global food demands and challenges due to climate change. Understanding the genetic basis of diversification and trait improvement will allow for more rapid genome-guided improvement of potato in future breeding efforts.

Survey of Nongovernmental Organizations Providing Pediatric Cardiovascular Care in Low- and Middle-Income Countries

PubMed Central

Nguyen, Nguyenvu; Jacobs, Jeffrey P.; Dearani, Joseph A.; Weinstein, Samuel; Novick, William M.; Jacobs, Marshall L.; Massey, Jeremy; Pasquali, Sara K.; Walters, Henry L.; Drullinsky, David; Stellin, Giovanni; Tchervenkov, Christo I.

2014-01-01

Background Nearly 90% of the children with heart disease in low- and middle-income countries (LMICs) cannot access cardiovascular (CV) services. Limitations include inadequate financial, human, and infrastructure resources. Nongovernmental organizations (NGOs) have played crucial roles in providing clinical services and infrastructure supports to LMICs CV programs; however, these outreach efforts are dispersed, inadequate, and lack coordination. Methods A survey was sent to members of the World Society for Pediatric and Congenital Heart Society and PediHeart. Results A clearinghouse was created to provide information on NGO structures, geographic reach, and scope of services. The survey identified 80 NGOs supporting CV programs in 92 LMICs. The largest outreach efforts were in South and Central America (42%), followed by Africa (18%), Europe (17%), Asia (17%), and Asia-Western Pacific (6%). Most NGOs (51%) supported two to five outreach missions per year. The majority (87%) of NGOs provided education, diagnostics, and surgical or catheter-based interventions. Working jointly with LMIC partners, 59% of the NGOs performed operations in children and infants; 41% performed nonbypass neonatal operations. Approximately a quarter (26%) reported that partner sites do not perform interventions in between missions. Conclusions Disparity and inadequacy in pediatric CV services remain an important problem for LMICs. A global consensus and coordinated efforts are needed to guide strategies on the development of regional centers of excellence, a global outcome database, and a CV program registry. Future efforts should be held accountable for impacts such as growth in the number of independent LMIC programs as well as reduction in mortality and patient waiting lists. PMID:24668973

Harm reduction and cessation efforts and interest in cessation resources among survivors of smoking-related cancers

PubMed Central

Berg, Carla J.; Carpenter, Matthew J.; Jardin, Bianca; Ostroff, Jamie S.

2013-01-01

Purpose Despite the well-established risks associated with persistent smoking, many cancer survivors who were active smokers at the time of cancer diagnosis continue to smoke. In order to guide the development of tobacco cessation interventions for cancer survivors, a better understanding is needed regarding post-diagnosis quitting efforts. Thus, we examined quitting and reduction efforts and interest in cessation resources among cancer survivors who self-identified as current smokers at the time of diagnosis. Methods We conducted analyses of survey participants (n=54) who were current smokers at the time of cancer diagnosis and were continued smokers at the time of assessment. We also conducted semi-structured interviews (n=21) among a subset of those who either continued to smoke or quit smoking post cancer diagnosis. Results Among our survey participants, 22.2% had ever used behavioral cessation resources and 66.7% had use pharmacotherapy, while 62.8% had interest in future use of behavioral cessation resources and 75.0% had interest in pharmacotherapy. The majority reported some quitting efforts including making quit attempts, using cessation medications, and reducing their daily cigarette consumption. Semi-structured interview data revealed various strategies used to aid in smoking reduction and cessation as well as variability in preferences for cessation resources. Conclusions Cancer patients who smoke following diagnosis often engage in smoking reduction and cessation-related behaviors, which may reflect their motivation to reduce their smoking-related risks. They also report high interest in cessation resources. Thus, it is important to explore the acceptability and effectiveness of different cessation intervention components among this group. PMID:23307036

Advancing Value Assessment in the United States: A Multistakeholder Perspective.

PubMed

Sorenson, Corinna; Lavezzari, Gabriela; Daniel, Gregory; Burkholder, Randy; Boutin, Marc; Pezalla, Edmund; Sanders, Gillian; McClellan, Mark

2017-02-01

Rising costs without perceived proportional improvements in quality and outcomes have motivated fundamental shifts in health care delivery and payment to achieve better value. Aligned with these efforts, several value assessment frameworks have been introduced recently to help providers, patients, and payers better understand the potential value of drugs and other interventions and make informed decisions about their use. Given their early stage of development, it is imperative to evaluate these efforts on an ongoing basis to identify how best to support and improve them moving forward. This article provides a multistakeholder perspective on the key limitations and opportunities posed by the current value assessment frameworks and areas of and actions for improvement. In particular, we outline 10 fundamental guiding principles and associated strategies that should be considered in subsequent iterations of the existing frameworks or by emerging initiatives in the future. Although value assessment frameworks may not be able to meet all the needs and preferences of stakeholders, we contend that there are common elements and potential next steps that can be supported to advance value assessment in the United States. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Hurricane Sandy science plan: coastal impact assessments

USGS Publications Warehouse

Stronko, Jakob M.

2013-01-01

Hurricane Sandy devastated some of the most heavily populated eastern coastal areas of the Nation. With a storm surge peaking at more than 19 feet, the powerful landscape-altering destruction of Hurricane Sandy is a stark reminder of why the Nation must become more resilient to coastal hazards. In response to this natural disaster, the U.S. Geological Survey (USGS) received a total of $41.2 million in supplemental appropriations from the Department of the Interior (DOI) to support response, recovery, and rebuilding efforts. These funds support a science plan that will provide critical scientific information necessary to inform management decisions for recovery of coastal communities, and aid in preparation for future natural hazards. This science plan is designed to coordinate continuing USGS activities with stakeholders and other agencies to improve data collection and analysis that will guide recovery and restoration efforts. The science plan is split into five distinct themes: coastal topography and bathymetry, impacts to coastal beaches and barriers, impacts of storm surge, including disturbed estuarine and bay hydrology, impacts on environmental quality and persisting contaminant exposures, impacts to coastal ecosystems, habitats, and fish and wildlife. This fact sheet focuses assessing impacts to coastal beaches and barriers.

The next generation of similarity measures that fully explore the semantics in biomedical ontologies.

PubMed

Couto, Francisco M; Pinto, H Sofia

2013-10-01

There is a prominent trend to augment and improve the formality of biomedical ontologies. For example, this is shown by the current effort on adding description logic axioms, such as disjointness. One of the key ontology applications that can take advantage of this effort is the conceptual (functional) similarity measurement. The presence of description logic axioms in biomedical ontologies make the current structural or extensional approaches weaker and further away from providing sound semantics-based similarity measures. Although beneficial in small ontologies, the exploration of description logic axioms by semantics-based similarity measures is computational expensive. This limitation is critical for biomedical ontologies that normally contain thousands of concepts. Thus in the process of gaining their rightful place, biomedical functional similarity measures have to take the journey of finding how this rich and powerful knowledge can be fully explored while keeping feasible computational costs. This manuscript aims at promoting and guiding the development of compelling tools that deliver what the biomedical community will require in a near future: a next-generation of biomedical similarity measures that efficiently and fully explore the semantics present in biomedical ontologies.

Enhanced Adaptive Management: Integrating Decision Analysis, Scenario Analysis and Environmental Modeling for the Everglades

PubMed Central

Convertino, Matteo; Foran, Christy M.; Keisler, Jeffrey M.; Scarlett, Lynn; LoSchiavo, Andy; Kiker, Gregory A.; Linkov, Igor

2013-01-01

We propose to enhance existing adaptive management efforts with a decision-analytical approach that can guide the initial selection of robust restoration alternative plans and inform the need to adjust these alternatives in the course of action based on continuously acquired monitoring information and changing stakeholder values. We demonstrate an application of enhanced adaptive management for a wetland restoration case study inspired by the Florida Everglades restoration effort. We find that alternatives designed to reconstruct the pre-drainage flow may have a positive ecological impact, but may also have high operational costs and only marginally contribute to meeting other objectives such as reduction of flooding. Enhanced adaptive management allows managers to guide investment in ecosystem modeling and monitoring efforts through scenario and value of information analyses to support optimal restoration strategies in the face of uncertain and changing information. PMID:24113217

Assessing Cognitive Function in Bipolar Disorder: Challenges and Recommendations for Clinical Trial Design

PubMed Central

Burdick, Katherine E.; Ketter, Terence A.; Goldberg, Joseph F.; Calabrese, Joseph R.

2015-01-01

OBJECTIVE Neurocognitive impairment in schizophrenia has been recognized for more than a century. In contrast, only recently have significant neurocognitive deficits been recognized in bipolar disorder. Converging data suggest the importance of cognitive problems in relation to quality of life in bipolar disorder, highlighting the need for treatment and prevention efforts targeting cognition in bipolar patients. Future treatment trials targeting cognitive deficits will be met with methodological challenges due to the inherent complexity and heterogeneity of the disorder, including significant diagnostic comorbidities, the episodic nature of the illness, frequent use of polypharmacy, cognitive heterogeneity, and a lack of consensus regarding measurement of cognition and outcome in bipolar patients. Guidelines for use in designing future trials are needed. PARTICIPANTS The members of the consensus panel (each of the bylined authors) were selected based upon their expertise in bipolar disorder. Dr. Burdick is a neuropsychologist who has studied cognition in this illness for 15 years; Drs. Ketter, Calabrese, and Goldberg each bring considerable expertise in the treatment of bipolar disorder both within and outside of controlled clinical trials. This consensus statement was derived from work together at scientific meetings (e.g. symposium presention at the 2014 Annual meeting of the American Society of Clinical Psychopharmacology, among others) and ongoing discussions by conference call. With the exception of the public presentations on this topic, these meetings were closed to outside participants. EVIDENCE A literature review was undertaken by the authors to identify illness-specific challenges relevant to the design and conduct of treatment trials targeting neurocognition in bipolar disorder. Expert opinion from each of the authors guided the consensus recommendations. CONSENSUS PROCESS Consensus recommendations, reached by unanimous opinion of the authors, are provided here as a preliminary guide for future trial design. Recommendations comprise exclusion of certain syndromal level comorbid diagnoses and current affective instability, restrictions on numbers and types of medications, and use of pre-screening assessment to ensure enrollment of subjects with adequate objective evidence of baseline cognitive impairment. CONCLUSIONS Clinical trials to address cognitive deficits in bipolar disorder face distinctive design challenges. As such trials move from proof-of-concept to confirmation of clinical efficacy, it will be important to incorporate distinctive design modifications to adequately address these challenges and increase the likelihood of demonstrating cognitive remediation effects. The field is now primed to address these challenges and a comprehensive effort to formalize best practice guidelines will be a critically important next step. PMID:25830456

CAD/CAM-produced surgical guides: Optimizing the treatment workflow.

PubMed

Neugebauer, J; Kistler, F; Kistler, S; Züdorf, G; Freyer, D; Ritter, L; Dreiseidler, T; Kusch, J; Zöller, J E

2011-01-01

The increased availability of devices for 3D radiological diagnosis allows the more frequent use of CAD/CAM-produced surgical guides for implant placement. The conventional workflow requires a complex logistic chain which is time-consuming and costly. In a pilot study, the workflow of directly milled surgical guides was evaluated. These surgical guides were designed based on the fusion of an optical impression and the radiological data. The clinical use showed that the surgical guides could be accurately placed on the residual dentition without tipping movements. The conventional surgical guides were used as a control for the manual check of the deviation of the implant axis. The direct transfer of the digital planning data allows the fabrication of surgical guides in an external center without the need of physical transport, which reduces the logistic effort and expense of the central fabrication of surgical guides.

TECHNOLOGY TRANSFER TO U.S. INDEPENDENT OIL AND NATURAL GAS PRODUCERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unknown

2002-11-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of assisting U.S. independent oil and gas producers make timely, informed technology decisions by providing access to information during Fiscal Year 2002 (FY02). Functioning as a cohesive national organization, PTTC has active grassroots programs through its ten Regional Lead Organizations (RLOs) and three satellite offices that efficiently extend the program reach. They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, various technical publications and othermore » outreach efforts. These are guided by regional Producer Advisory Groups (PAGs), who are area operators and service companies working with the regional networks. The role of the national Headquarters (HQ) staff includes planning and managing the PTTC program, conducting nation wide technology transfer activities, and implementing a comprehensive communications effort. The organization effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy with state and industry funding to achieve important goals for all of these sectors. This integrated funding base is combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff to achieve notable results. PTTC is increasingly recognized as a critical resource for information and access to technologies, especially for smaller companies without direct contact with R&D efforts. The DOE participation is managed through the National Energy Technology Laboratory (NETL), which deploys a national natural gas program via the Strategic Center for Natural Gas (SCNG) and a national oil program through the National Petroleum Technology Office (NTPO). This technical progress report summarizes PTTC's accomplishments during FY02. Activities were maintained at recent record levels. Strategic planning from multiple sources within the framework of the organization gives PTTC the vision to have even more impact in the future. The Houston Headquarters (HQ) location has strived to serve PTTC well in better connecting with producers and the service sector. PTTC's reputation for unbiased bottom line information stimulates cooperative ventures with other organizations. Efforts to build the contact database, exhibit at more trade shows and a new E-mail Technology Alert service are expanding PTTC's audience. All considered, the PTTC network has proven to be an effective way to reach domestic producers locally, regionally and nationally.« less

SEARCH: Study of Environmental Arctic Change--A System-scale, Cross-disciplinary, Long-term Arctic Research Program

NASA Astrophysics Data System (ADS)

Wiggins, H. V.; Schlosser, P.; Fox, S. E.

2009-12-01

The Study of Environmental Arctic Change (SEARCH) is a multi-agency effort to observe, understand, and guide responses to changes in the changing arctic system. Under the SEARCH program, guided by the Science Steering Committee (SSC), the Observing, Understanding, and Responding to Change panels, and the Interagency Program Management Committee (IPMC), scientists with a variety of expertise work together to achieve goals of the program. Over 150 projects and activities contribute to SEARCH implementation. The Observing Change component is underway through the NSF’s Arctic Observing Network (AON), NOAA-sponsored atmospheric and sea ice observations, and other relevant national and international efforts, including the EU-sponsored Developing Arctic Modeling and Observing Capabilities for Long-term Environmental Studies (DAMOCLES) Program. The Understanding Change component of SEARCH consists of modeling and analysis efforts, including the Sea Ice Outlook project, an international effort to provide a community-wide summary of the expected September arctic sea ice minimum. The Understanding Change component also has strong linkages to programs such as the NSF Arctic System Science (ARCSS) Program. The Responding to Change element will be launched through stakeholder-focused research and applications addressing social and economic concerns. As a national program under the International Study of Arctic Change (ISAC), SEARCH is working to expand international connections. The State of the Arctic Conference (soa.arcus.org), to be held 16-19 March 2010 in Miami, will be a milestone activity of SEARCH and will provide an international forum for discussion of future research directions aimed toward a better understanding of the arctic system and its trajectory. SEARCH is sponsored by eight U.S. agencies that comprise the IPMC, including: the National Science Foundation (NSF), the National Oceanic and Atmospheric Administration (NOAA), the National Aeronautics and Space Administration (NASA), the Department of Defense (DOD), the Department of Energy (DOE), the Department of the Interior (DOI), the Smithsonian Institution, and the U.S. Department of Agriculture (USDA). The U.S. Arctic Research Commission (USARC) participates as an IPMC observer. For more information, visit the website at: http://www.arcus.org/search or contact: Helen V. Wiggins: helen@arcus.org, SEARCH Project Office, ARCUS; or Peter Schlosser, schlosser@ldeo.columbia.edu, SEARCH SSC Chair.

Identifying and Planning for New and Emerging Occupations: A Suggested Guide.

ERIC Educational Resources Information Center

Meleen, Paulette; And Others

Intended for use by State vocational education directors and curriculum planners, this guide documents the results of a project which developed and applied a process for identifying new and emerging occupations for skilled and technical areas, part of a larger effort to assist the alignment of vocational and technical program offerings with new…

PDQ: Planning and Development of Quality Services in the Schools, Instructional Guide, Student Manual and Reference Materials.

ERIC Educational Resources Information Center

Wright, Sandra Raymore

The instructional guide, student manual, and reference materials were developed by the PDQ Project, Planning and Development of Quality Services in the Schools, an effort by the American Speech-Language-Hearing Association to provide public school personnel working with communication disordered children with information and training related to…

Teen Drinking Prevention Program. Communicator's Guide.

ERIC Educational Resources Information Center

Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.

Underage drinking is a serious national problem--alcohol-related injuries are a leading cause of death and injury among young people in the United States today. This guide is designed to help individuals who wish to be involved in a national effort to prevent underage drinking. It includes materials and messages that can be reproduced, as well as…

16 CFR 238.1 - Bait advertisement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Bait advertisement. 238.1 Section 238.1 Commercial Practices FEDERAL TRADE COMMISSION GUIDES AND TRADE PRACTICE RULES GUIDES AGAINST BAIT ADVERTISING § 238.1 Bait advertisement. No advertisement containing an offer to sell a product should be published when the offer is not a bona fide effort...

JTPA: Targeting, Outreach and Recruitment. A Technical Assistance and Training Series.

ERIC Educational Resources Information Center

Employment and Training Administration (DOL), Washington, DC.

This guide, which was developed with input from more than 120 Job Training Partnership Act (JTPA) programs across the United States, is designed to give JTPA program staff new ideas for conducting their targeting, outreach, and recruitment efforts. Presented first are an overview of the guide's contents and suggestions for using it. The first five…

Excellence in Educational Fund Raising at America's Community Colleges and a Key Resources Guide for Educational Fund Raising.

ERIC Educational Resources Information Center

Ryan, G. Jeremiah

Designed to encourage and inform community college efforts to secure private financial support, this literature review and resource guide examine the current status of fund raising at community colleges and list pertinent information sources. After introductory comments advocate increased community college involvement in fund raising, the paper…

Community How To Guide On Underage Drinking Prevention: Needs Assessment and Strategic Planning.

ERIC Educational Resources Information Center

National Association of Governors' Highway Safety Representatives.

A comprehensive needs assessment is the critical first step a coalition or organization must take in order to develop an effective and successful underage drinking prevention effort. This guide details the elements of a needs assessment. Beginning with data, the booklet walks the reader through the process organizations must follow to obtain all…

Bibliography of In-House and Contract Reports. Supplement 9.

DTIC Science & Technology

1981-02-01

11;il CasCil roads andl ril roads would significantlN rcduLcc tlic ~anIual labor IMnOls d III V, i 1111111 d il.1 . graphic data bascs. ile effort...GUIDE FOR CLIMA TE (Rpt. No. 5 in the ETL Series on Guides for Army Terrain Analysts) September 1980 Keywords: Climatic Analysis, Factor Mapping

Advanced Medical Technology and Network Systems Research.

DTIC Science & Technology

1999-09-01

for image-guided therapies . Advanced technologies included in this report are impedance imaging and a palpation training system. 14. SUBJECT...Summary 1 Virtual Clinic for Patients with Chronic Illness Project Planning Document • 2 Telemedicine for Hemodialysis 21 A...imaging systems and’ surgical procedures effort is accomplished in part by establishing the technology requirements for image-guided therapies . Advanced

Physical Education Opportunity Program for Exceptional Learners (PEOPEL): A Teacher's Guide for Secondary Schools. Second Edition.

ERIC Educational Resources Information Center

Irmer, Larry D.; And Others

The instructional guide for PEOPEL (Physical Education Opportunity Program for Exceptional Learners) contains 36 units of instruction for use with handicapped junior and senior high school students. The units contain basic performance objectives which have been task analyzed in an effort to individualize instruction. Each unit is divided into four…

From Quisqueya: In Search of New Horizons. Dominican Cultural Heritage Resource Guide.

ERIC Educational Resources Information Center

Alcantara, Anibal; Aquino, Jaime; Lantigua, Juan A.; Rodriguez, Digna; Soto, Alejandro

This cultural heritage resource guide has been prepared as a tool for teachers to help them understand the cultural heritage of Dominican students and their communities. The Dominican Republic, which occupies two-thirds of the island of Hispaniola, has a long history dominated by the struggle for independence. In their efforts to create a better…

The Pennsylvania Migrant Adult Model Curriculum Resource Guide: A Needs Assessment Approach.

ERIC Educational Resources Information Center

Williams, Miriam Q.; Labriola, Robert J.

Providing a data basis for the planning and implementation of educational programs for migrant adults, this guide is a product of a year-long research effort which focused on the adult migrants in Pennsylvania, their educational needs and interests, the unique factors which should be considered in designing and providing educational programs and…

Citizenship: A Curriculum Guide. Grade Nine.

ERIC Educational Resources Information Center

Indiana State Dept. of Public Instruction, Indianapolis.

This guide is designed to be useful to teachers as they outline courses and daily lesson plans. No attempt has been made to plan in detail for a teacher, however, content outlines are thorough. An effort has been made to acquaint the teacher with the formulation and use of generalizations as an aid to teaching pupils to think; critically suggested…

Continuity in Early Childhood: A Framework for Home, School, and Community Linkages. Revised Edition.

ERIC Educational Resources Information Center

Regional Educational Laboratories Early Childhood Collaboration Network.

This guide details a framework for supporting the efforts of home, school, and community partners to improve continuity and transition in early childhood. Following an introduction describing continuity in early childhood, the importance of a smooth transition, and the eight elements of early childhood continuity, the guide is presented in eight…

Presenter's Guide to Perspectives (Law-Related Education). Draft.

ERIC Educational Resources Information Center

Pratt, Robert B.

This document is the presenter's guide to SO 008 871. The document is the result of three and one-half years of effort to improve social studies in the secondary schools in Iowa. Perspectives, part one of the two-part series, presents information and background to aid in the reform, innovation, and evaluation of social studies programs. This…

77 FR 24671 - Compliance Guide for Residue Prevention and Agency Testing Policy for Residues

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... cows and bob veal, that account for 90 percent of the residues found in animals presented for slaughter, pointing to the need for the Agency to continue to focus compliance efforts on cull dairy cows and bob veal. This Compliance Guide emphasizes that establishments, especially those that slaughter dairy cows and...

Careers in Industrial Sewing for the Apparel Manufacturing Industry: Teacher-Student Guide.

ERIC Educational Resources Information Center

American Apparel Manufacturers Association, Arlington, VA. Education Committee.

The teacher-student guide has been developed as a service to schools in an effort to help them organize and operate meaningful courses in apparel manufacturing. For the school it furnishes practical information in implementing the course, such as facility design, equipment requirements, and teacher selection. For the teacher it provides a…

Achievable future conditions as a framework for guiding forest conservation and management

Treesearch

S.W. Golladay; K.L. Martin; J. M. Vose; D. N. Wear; A.P. Covich; R.J. Hobbs; Kier Klepzig; G.E. Likens; R.J. Naiman; A.W. Shearer

2016-01-01

We contend that traditional approaches to forest conservation and management will be inadequate given the predicted scale of social-economic and biophysical changes in the 21st century. New approaches, focused on anticipating and guiding ecological responses to change, are urgently needed to ensure the full value of forest ecosystem services for future generations....

Shaping up Your Financial Future, Grades 6-8. Teacher Guide [and] Student Workouts. Financial Fitness for Life.

ERIC Educational Resources Information Center

Flowers, Barbara; Gallaher, Sheryl Szot

Middle school students enjoy personal finance because it involves making decisions about their lives, both in the present and in the future. This teacher's guide and student workouts package consists of 17 economics lessons for students at grades 6-8 that are divided into 5 theme areas: the economic way of thinking; earning an income; saving;…

Futuring for Future Ready Librarians

ERIC Educational Resources Information Center

Figueroa, Miguel A.

2018-01-01

Futurists and foresight professionals offer several guiding principles for thinking about the future. These principles can help people to think about the future and become more powerful players in shaping the preferred futures they want for themselves and their communities. The principles also fit in well as strategies to support the Future Ready…

Harm reduction and cessation efforts and interest in cessation resources among survivors of smoking-related cancers.

PubMed

Berg, Carla J; Carpenter, Matthew J; Jardin, Bianca; Ostroff, Jamie S

2013-03-01

Despite the well-established risks associated with persistent smoking, many cancer survivors who were active smokers at the time of cancer diagnosis continue to smoke. In order to guide the development of tobacco cessation interventions for cancer survivors, a better understanding is needed regarding post-diagnosis quitting efforts. Thus, we examined quitting and reduction efforts and interest in cessation resources among cancer survivors who self-identified as current smokers at the time of diagnosis. We conducted analyses of survey participants (n = 54) who were current smokers at the time of cancer diagnosis and were continued smokers at the time of assessment. We also conducted semi-structured interviews (n = 21) among a subset of those who either continued to smoke or quit smoking post-cancer diagnosis. Among our survey participants, 22.2 % had ever used behavioral cessation resources and 66.7 % had use pharmacotherapy, while 62.8 % had interest in future use of behavioral cessation resources and 75.0 % had interest in pharmacotherapy. The majority reported some quitting efforts including making quit attempts, using cessation medications, and reducing their daily cigarette consumption. Semi-structured interview data revealed various strategies used to aid in smoking reduction and cessation as well as variability in preferences for cessation resources. Cancer patients who smoke following diagnosis often engage in smoking reduction and cessation-related behaviors, which may reflect their motivation to reduce their smoking-related risks. They also report high interest in cessation resources. Thus, it is important to explore the acceptability and effectiveness of different cessation intervention components among this group. Cancer survivors who smoke demonstrate actions toward harm reduction and cessation. They should inquire about potential resources that might facilitate their efforts among their healthcare providers and enlist support and advice from others around them to bolster their efforts.

REGIONAL COORDINATION OF NOAA/NATIONAL WEATHER SERVICE CLIMATE SERVICES IN THE WEST (Invited)

NASA Astrophysics Data System (ADS)

Bair, A.

2009-12-01

The climate services program is an important component in the National Weather Service’s (NWS) mission, and is one of the National Oceanic and Atmospheric Administration’s (NOAA) top five priorities. The Western Region NWS started building a regional and local climate services program in late 2001, with input from local NWS offices and key partners. The original goals of the Western Region climate services program were to strive to provide climate services that were useful, easily accessible, well understood, coordinated and supported by partners, and reflect customer needs. While the program has evolved, and lessons have been learned, these goals are still guiding the program. Regional and local level Climate Services are a fundamental part of NOAA/NWS’s current and future role in providing climate services. There is an ever growing demand for climate information and services to aid the public in decision-making and no single entity alone can provide the range of information and services needed. Coordination and building strong partnerships at the local and regional levels is the key to providing optimal climate services. Over the past 8 years, Western Region NWS has embarked on numerous coordination efforts to build the regional and local climate services programs, such as: collaboration (both internally and externally to NOAA) meetings and projects, internal staff training, surveys, and outreach efforts. In order to gain regional and local buy-in from the NWS staff, multiple committees were utilized to plan and develop goals and structure for the program. While the regional and local climate services program in the NWS Western Region has had many successes, there have been several important lessons learned from efforts that have not been as successful. These lessons, along with past experience, close coordination with partners, and the need to constantly improve/change the program as the climate changes, form the basis for future program development and goals.

Soil Carbon Variability and Change Detection in the Forest Inventory Analysis Database of the United States

NASA Astrophysics Data System (ADS)

Wu, A. M.; Nater, E. A.; Dalzell, B. J.; Perry, C. H.

2014-12-01

The USDA Forest Service's Forest Inventory Analysis (FIA) program is a national effort assessing current forest resources to ensure sustainable management practices, to assist planning activities, and to report critical status and trends. For example, estimates of carbon stocks and stock change in FIA are reported as the official United States submission to the United Nations Framework Convention on Climate Change. While the main effort in FIA has been focused on aboveground biomass, soil is a critical component of this system. FIA sampled forest soils in the early 2000s and has remeasurement now underway. However, soil sampling is repeated on a 10-year interval (or longer), and it is uncertain what magnitude of changes in soil organic carbon (SOC) may be detectable with the current sampling protocol. We aim to identify the sensitivity and variability of SOC in the FIA database, and to determine the amount of SOC change that can be detected with the current sampling scheme. For this analysis, we attempt to answer the following questions: 1) What is the sensitivity (power) of SOC data in the current FIA database? 2) How does the minimum detectable change in forest SOC respond to changes in sampling intervals and/or sample point density? Soil samples in the FIA database represent 0-10 cm and 10-20 cm depth increments with a 10-year sampling interval. We are investigating the variability of SOC and its change over time for composite soil data in each FIA region (Pacific Northwest, Interior West, Northern, and Southern). To guide future sampling efforts, we are employing statistical power analysis to examine the minimum detectable change in SOC storage. We are also investigating the sensitivity of SOC storage changes under various scenarios of sample size and/or sample frequency. This research will inform the design of future FIA soil sampling schemes and improve the information available to international policy makers, university and industry partners, and the public.

Maximizing Your Grant Development: A Guide for CEOs.

ERIC Educational Resources Information Center

Snyder, Thomas

1993-01-01

Since most private and public sources of external funding generally expect increased effort and accountability, Chief Executive Officers (CEOs) at two-year colleges must inform faculty and staff that if they do not expend extra effort their college will not receive significant grants. The CEO must also work with the college's professional…

Understanding Succession Planning and Management Efforts at Midwestern University: A Mixed Methods Study

ERIC Educational Resources Information Center

Mateso, Peter E. E.

2010-01-01

The purpose of this concurrent triangulation mixed methods study was to understand the status of succession planning and management (SPM) efforts of the subject university as perceived by the fulltime academic and fulltime administrative staff. Four research questions guided this study: (1) how do fulltime academic staff and fulltime…

Planning in Public Education: Lessons from Horace Mann and Henry Barnard

ERIC Educational Resources Information Center

Henkin, Alan B.; Ignasias, C. Dennis

1978-01-01

A handful of educational reformers from each generation effectively muster and sustain public support in efforts to advance their visions for education. Here is an account of the efforts of Horace Mann and Henry Barnard acting as educational advocates and consensus builders who evoked public responsiveness and guided their constituencies toward…

Supporting Minority-Serving Institutions in Their Program Improvement Efforts: A Responsive Technical Assistance Approach

ERIC Educational Resources Information Center

Bay, Mary; Lopez-Reyna, Norma A.; Guillory, Barbara L.

2012-01-01

To reform a special education teacher preparation program can be gratifying, difficult, complex, political, and urgently needed. The Monarch Center, a federally funded technical assistance center, was established to guide and support minority-serving institutions in their efforts to improve their teacher preparation programs. Four guidelines…

Empathy and Effortful Control Effects on Early Adolescents' Aggression: When Do Students' Perceptions of Their School Climate Matter?

ERIC Educational Resources Information Center

Batanova, Milena; Loukas, Alexandra

2016-01-01

Guided by the social emotional learning framework, this study examined whether early adolescents' social awareness (empathic concern, perspective taking) and self-management (effortful control) would uniquely contribute to early adolescents' subsequent forms of aggression, and whether perceptions of their school climate (friction, cohesion,…

Optimising translational oncology in clinical practice: strategies to accelerate progress in drug development.

PubMed

Stahel, R; Bogaerts, J; Ciardiello, F; de Ruysscher, D; Dubsky, P; Ducreux, M; Finn, S; Laurent-Puig, P; Peters, S; Piccart, M; Smit, E; Sotiriou, C; Tejpar, S; Van Cutsem, E; Tabernero, J

2015-02-01

Despite intense efforts, the socioeconomic burden of cancer remains unacceptably high and treatment advances for many common cancers have been limited, suggesting a need for a new approach to drug development. One issue central to this lack of progress is the heterogeneity and genetic complexity of many tumours. This results in considerable variability in therapeutic response and requires knowledge of the molecular profile of the tumour to guide appropriate treatment selection for individual patients. While recent advances in the molecular characterisation of different cancer types have the potential to transform cancer treatment through precision medicine, such an approach presents a major economic challenge for drug development, since novel targeted agents may only be suitable for a small cohort of patients. Identifying the patients who would benefit from individual therapies and recruiting sufficient numbers of patients with particular cancer subtypes into clinical trials is challenging, and will require collaborative efforts from research groups and industry in order to accelerate progress. A number of molecular screening platforms have already been initiated across Europe, and it is hoped that these networks, along with future collaborations, will benefit not only patients but also society through cost reductions as a result of more efficient use of resources. This review discusses how current developments in translational oncology may be applied in clinical practice in the future, assesses current programmes for the molecular characterisation of cancer and describes possible collaborative approaches designed to maximise the benefits of translational science for patients with cancer. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Applying comprehensive environmental assessment to research planning for multiwalled carbon nanotubes: Refinements to inform future stakeholder engagement.

PubMed

Powers, Christina M; Grieger, Khara; Meacham, Connie A; Gooding, Meredith Lassiter; Gift, Jeffrey S; Lehmann, Geniece M; Hendren, Christine O; Davis, J Michael; Burgoon, Lyle

2016-01-01

Risk assessments and risk management efforts to protect human health and the environment can benefit from early, coordinated research planning by researchers, risk assessors, and risk managers. However, approaches for engaging these and other stakeholders in research planning have not received much attention in the environmental scientific literature. The Comprehensive Environmental Assessment (CEA) approach under development by the United States Environmental Protection Agency (USEPA) is a means to manage complex information and input from diverse stakeholder perspectives on research planning that will ultimately support environmental and human health decision making. The objectives of this article are to 1) describe the outcomes of applying lessons learned from previous CEA applications to planning research on engineered nanomaterial, multiwalled carbon nanotubes (MWCNTs) and 2) discuss new insights and refinements for future efforts to engage stakeholders in research planning for risk assessment and risk management of environmental issues. Although framed in terms of MWCNTs, this discussion is intended to enhance research planning to support assessments for other environmental issues as well. Key insights for research planning include the potential benefits of 1) ensuring that participants have research, risk assessment, and risk management expertise in addition to diverse disciplinary backgrounds; 2) including an early scoping step before rounds of formal ratings; 3) using a familiar numeric scale (e.g., US dollars) versus ordinal rating scales of "importance"; 4) applying virtual communication tools to supplement face-to-face interaction between participants; and 5) refining criteria to guide development of specific, actionable research questions. © 2015 SETAC.

The NASA Mission Operations and Control Architecture Program

NASA Technical Reports Server (NTRS)

Ondrus, Paul J.; Carper, Richard D.; Jeffries, Alan J.

1994-01-01

The conflict between increases in space mission complexity and rapidly declining space mission budgets has created strong pressures to radically reduce the costs of designing and operating spacecraft. A key approach to achieving such reductions is through reducing the development and operations costs of the supporting mission operations systems. One of the efforts which the Communications and Data Systems Division at NASA Headquarters is using to meet this challenge is the Mission Operations Control Architecture (MOCA) project. Technical direction of this effort has been delegated to the Mission Operations Division (MOD) of the Goddard Space Flight Center (GSFC). MOCA is to develop a mission control and data acquisition architecture, and supporting standards, to guide the development of future spacecraft and mission control facilities at GSFC. The architecture will reduce the need for around-the-clock operations staffing, obtain a high level of reuse of flight and ground software elements from mission to mission, and increase overall system flexibility by enabling the migration of appropriate functions from the ground to the spacecraft. The end results are to be an established way of designing the spacecraft-ground system interface for GSFC's in-house developed spacecraft, and a specification of the end to end spacecraft control process, including data structures, interfaces, and protocols, suitable for inclusion in solicitation documents for future flight spacecraft. A flight software kernel may be developed and maintained in a condition that it can be offered as Government Furnished Equipment in solicitations. This paper describes the MOCA project, its current status, and the results to date.

[Guided and computer-assisted implant surgery and prosthetic: The continuous digital workflow].

PubMed

Pascual, D; Vaysse, J

2016-02-01

New continuous digital workflow protocols of guided and computer-assisted implant surgery improve accuracy of implant positioning. The design of the future prosthesis is based on the available prosthetic space, gingival height and occlusal relationship with the opposing and adjacent teeth. The implant position and length depend on volume, density and bone quality, gingival height, tooth-implant and implant-implant distances, implant parallelism, axis and type of the future prosthesis. The crown modeled on the software will therefore serve as a guide to the future implant axis and not the reverse. The guide is made by 3D printing. The software determines surgical protocol with the drilling sequences. The unitary or plural prosthesis, modeled on the software and built before surgery, is loaded directly after implant placing, if needed. These protocols allow for a full continuity of the digital workflow. The software provides the surgeon and the dental technician a total freedom for the prosthetic-surgery guide design and the position of the implants. The prosthetic project, occlusal and aesthetic, taking the bony and surgical constraints into account, is optimized. The implant surgery is simplified and becomes less "stressful" for the patient and the surgeon. Guided and computer-assisted surgery with continuous digital workflow is becoming the technique of choice to improve the accuracy and quality of implant rehabilitation. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Home Economics Education Career Path Guide and Model Curriculum Standards.

ERIC Educational Resources Information Center

California State Univ., Northridge.

This curriculum guide developed in California and organized in 10 chapters, provides a home economics education career path guide and model curriculum standards for high school home economics programs. The first chapter contains information on the following: home economics education in California, home economics careers for the future, home…

Nutrition and Food Science. Teacher's Instructional Guide.

ERIC Educational Resources Information Center

Hays, Tricia

This teaching, guide for a high school nutrition and food science course, includes introductory information about the course, course design, facilities and equipment, Future Homemakers of America, and use of the guide. The course addresses nutrition and food science from the perspective of food habits and wellness; menu planning; special dietary…

Confronting Global Issues: A Multipurpose IR Simulation

ERIC Educational Resources Information Center

Shellman, Stephen M.; Turan, Kursad

2006-01-01

This article describes an international relations simulation that focuses on threats of transnational insurgent organizations, the future of the Iraqi regime, and the effect of globalization on foreign policies. It contains both the Simulation Director's Guide and the Participant's Guide. The guides explain the steps taken to run the simulation…

Kansas Business Education Curriculum Guide.

ERIC Educational Resources Information Center

Groneman, Nancy; Owen, Susan

This curriculum guide was developed to help business education teachers in Kansas improve and update their curricula to meet the needs of the present and future electronic office. The guide is based upon the premise that computer and keyboarding skills will be needed by all students and that communication skills and knowledge of word…

Physical Activity and Pregnancy: Past and Present Evidence and Future Recommendations

PubMed Central

Downs, Danielle Symons; Chasan-Taber, Lisa; Evenson, Kelly R.; Leiferman, Jenn; Yeo, SeonAe

2012-01-01

Purpose This review provides researchers and practitioners with an overview of the physical activity and pregnancy literature to promote prenatal physical activity, improve measurement, further elucidate the role of activity in reducing maternal health complications, and inform future research. Methods We examined past and present physical activity and pregnancy studies and highlight key papers with a particular focus on maternal health outcomes to best inform physical activity promotion efforts. Results This review discusses: (a) historical overview of prenatal physical activity with a specific focus on the physical activity guidelines, how they have changed over time, and how evidence of the effect of prenatal activity on maternal/fetal health outcomes has impacted clinical recommendations; (b) existing tools and challenges associated with measuring prenatal physical activity; (c) empirical evidence on the multi-level determinants of prenatal activity to help guide future intervention work; (d) empirical evidence of prenatal activity on adverse maternal outcomes (gestational diabetes mellitus, preeclampsia, excessive gestational weight gain) from observational and intervention studies; and (e) summary/recommendations for future research and practice. Conclusions The physical activity and pregnancy literature has evolved over the past 50 years and there is currently sufficient empirical evidence to support the promotion of moderate to vigorous prenatal physical activity for maternal health benefits. Future studies and interventions should be carefully-designed, theoretically driven, and include validated and reliable measures of activity. Researchers and practitioners should also consider the multifaceted determinants and outcomes of prenatal physical activity and intervening to promote physical activity before, during, and after pregnancy. PMID:23367811

Behavioral modeling of human choices reveals dissociable effects of physical effort and temporal delay on reward devaluation.

PubMed

Klein-Flügge, Miriam C; Kennerley, Steven W; Saraiva, Ana C; Penny, Will D; Bestmann, Sven

2015-03-01

There has been considerable interest from the fields of biology, economics, psychology, and ecology about how decision costs decrease the value of rewarding outcomes. For example, formal descriptions of how reward value changes with increasing temporal delays allow for quantifying individual decision preferences, as in animal species populating different habitats, or normal and clinical human populations. Strikingly, it remains largely unclear how humans evaluate rewards when these are tied to energetic costs, despite the surge of interest in the neural basis of effort-guided decision-making and the prevalence of disorders showing a diminished willingness to exert effort (e.g., depression). One common assumption is that effort discounts reward in a similar way to delay. Here we challenge this assumption by formally comparing competing hypotheses about effort and delay discounting. We used a design specifically optimized to compare discounting behavior for both effort and delay over a wide range of decision costs (Experiment 1). We then additionally characterized the profile of effort discounting free of model assumptions (Experiment 2). Contrary to previous reports, in both experiments effort costs devalued reward in a manner opposite to delay, with small devaluations for lower efforts, and progressively larger devaluations for higher effort-levels (concave shape). Bayesian model comparison confirmed that delay-choices were best predicted by a hyperbolic model, with the largest reward devaluations occurring at shorter delays. In contrast, an altogether different relationship was observed for effort-choices, which were best described by a model of inverse sigmoidal shape that is initially concave. Our results provide a novel characterization of human effort discounting behavior and its first dissociation from delay discounting. This enables accurate modelling of cost-benefit decisions, a prerequisite for the investigation of the neural underpinnings of effort-guided choice and for understanding the deficits in clinical disorders characterized by behavioral inactivity.

Behavioral Modeling of Human Choices Reveals Dissociable Effects of Physical Effort and Temporal Delay on Reward Devaluation

PubMed Central

Klein-Flügge, Miriam C.; Kennerley, Steven W.; Saraiva, Ana C.; Penny, Will D.; Bestmann, Sven

2015-01-01

There has been considerable interest from the fields of biology, economics, psychology, and ecology about how decision costs decrease the value of rewarding outcomes. For example, formal descriptions of how reward value changes with increasing temporal delays allow for quantifying individual decision preferences, as in animal species populating different habitats, or normal and clinical human populations. Strikingly, it remains largely unclear how humans evaluate rewards when these are tied to energetic costs, despite the surge of interest in the neural basis of effort-guided decision-making and the prevalence of disorders showing a diminished willingness to exert effort (e.g., depression). One common assumption is that effort discounts reward in a similar way to delay. Here we challenge this assumption by formally comparing competing hypotheses about effort and delay discounting. We used a design specifically optimized to compare discounting behavior for both effort and delay over a wide range of decision costs (Experiment 1). We then additionally characterized the profile of effort discounting free of model assumptions (Experiment 2). Contrary to previous reports, in both experiments effort costs devalued reward in a manner opposite to delay, with small devaluations for lower efforts, and progressively larger devaluations for higher effort-levels (concave shape). Bayesian model comparison confirmed that delay-choices were best predicted by a hyperbolic model, with the largest reward devaluations occurring at shorter delays. In contrast, an altogether different relationship was observed for effort-choices, which were best described by a model of inverse sigmoidal shape that is initially concave. Our results provide a novel characterization of human effort discounting behavior and its first dissociation from delay discounting. This enables accurate modelling of cost-benefit decisions, a prerequisite for the investigation of the neural underpinnings of effort-guided choice and for understanding the deficits in clinical disorders characterized by behavioral inactivity. PMID:25816114

Simple chained guide trees give high-quality protein multiple sequence alignments

PubMed Central

Boyce, Kieran; Sievers, Fabian; Higgins, Desmond G.

2014-01-01

Guide trees are used to decide the order of sequence alignment in the progressive multiple sequence alignment heuristic. These guide trees are often the limiting factor in making large alignments, and considerable effort has been expended over the years in making these quickly or accurately. In this article we show that, at least for protein families with large numbers of sequences that can be benchmarked with known structures, simple chained guide trees give the most accurate alignments. These also happen to be the fastest and simplest guide trees to construct, computationally. Such guide trees have a striking effect on the accuracy of alignments produced by some of the most widely used alignment packages. There is a marked increase in accuracy and a marked decrease in computational time, once the number of sequences goes much above a few hundred. This is true, even if the order of sequences in the guide tree is random. PMID:25002495

An airline study of advanced technology requirements for advanced high speed commercial engines. 3: Propulsion system requirements

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial transport engine are presented. The results of the phase 3 effort cover the requirements and objectives for future aircraft propulsion systems. These requirements reflect the results of the Task 1 and 2 efforts and serve as a baseline for future evaluations, specification development efforts, contract/purchase agreements, and operational plans for future subsonic commercial engines. This report is divided into five major sections: (1) management objectives for commercial propulsion systems, (2) performance requirements for commercial transport propulsion systems, (3) design criteria for future transport engines, (4) design requirements for powerplant packages, and (5) testing.

District Readiness to Support School Turnaround: A Users' Guide to Inform the Work of State Education Agencies and Districts

ERIC Educational Resources Information Center

Player, Daniel; Hambrick Hitt, Dallas; Robinson, William

2014-01-01

This guide provides state education agencies (SEAs) and districts (LEAs) with guidance about how to assess the district's readiness to support school turnaround initiatives. Often, school turnaround efforts focus only on the school's structure and leadership. Rarely do policymakers or practitioners think about school turnaround as a system-level…

The Promise and Challenge of Practice-Research Collaborations: Guiding Principles and Strategies for Initiating, Designing, and Implementing Program Evaluation Research

ERIC Educational Resources Information Center

Secret, Mary; Abell, Melissa L.; Berlin, Trey

2011-01-01

The authors present a set of guiding principles and strategies to facilitate the collaborative efforts of social work researchers and practitioners as they initiate, design, and implement outcome evaluations of human service interventions and programs. Beginning with an exploration of the interpersonal barriers to practice-research collaborations,…

Social Studies Introductory Level--Needs. Teacher's Guide & Resource Book = Araling Panlipunan: Intro--Pangangarlangn. Aug Patnubay Ng Guro at Hanguang Aklat.

ERIC Educational Resources Information Center

Berkeley Unified School District, CA. Asian American Bilingual Center.

This Pilipino teacher's guide is part of Berkeley, California Unified School District Asian American Bilingual Center's effort to foster the total growth of the child. To facilitate that growth, the Center has selected an interdisciplinary approach to curriculum development. Social studies themes and concepts provide the framework within which all…

Crash Injury Management: Emergency Medical Services for Traffic Law Enforcement Officers. Student Study Guide.

ERIC Educational Resources Information Center

National Highway Traffic Safety Administration (DOT), Washington, DC.

To assist in the continuing efforts to improve the safety of the motorist on the nation's highways and roads, this student guide provides a standardized approach for first responders to traffic accidents to learn emergency medical care. Training is provided in all aspects of emergency medical care required at the scene of a traffic accident.…

Tough Choices: A Guide to Administrative Cost Management in Colleges and Universities.

ERIC Educational Resources Information Center

Cresap, Rosslyn, VA.

This guide is a product of a study conducted as part of a broader effort by the Department of Education to identify the causes of rising college costs and find and disseminate ways to contain these costs. In institutions of higher education most costs are manageable and can be contained without jeopardizing key services. This can be achieved by…

German Language and Culture: 9-Year Program Guide to Implementation, Grades 4-5-6

ERIC Educational Resources Information Center

Alberta Education, 2008

2008-01-01

This implementation guide is intended to support the Grade 4 to Grade 6 portion of the German Language and Culture Nine-year Program (the program of studies). It was developed primarily for teachers, yet it includes information that may be useful for administrators and other stakeholders in their efforts to plan for and implement the new Chinese…

Evaluation of the Guided Occupational Orientation-Training and Job Placement Project Syracuse City School District.

ERIC Educational Resources Information Center

Holder, Harold D.; And Others

The report provides a summary of the independent, third party evaluation of the 1972-73 funding year of the Guided Occupational Orientation Project of the Syracuse City School District. A systems approach to evaluation was utilized in this effort. The funded project involved all three grade populations--elementary, junior high school, and senior…

A Parent Involvement Model for Use with Limited English Proficient High School Students. Teacher's Guide: The Vocationally Oriented Bilingual Curriculum.

ERIC Educational Resources Information Center

Trinity Coll., Washington, DC.

This teaching guide accompanying materials for parents to support the efforts of their limited-English-speaking high school children in a vocationally-oriented bilingual secondary program provides an explanation of the program and its objectives and suggests techniques for introducing and using the materials effectively with the parents. Steps to…

Strand I, Physical Health: Health Status. Health Curriculum Materials for Grades 4-6.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Curriculum Development Center.

This health curriculum guide, intended for use with children in grades four through six, contends that the school is in a unique position to supplement efforts by home and community in raising the levels of physical, mental, and social-emotional health for each child. The contents of the guide are presented in outline form and cover observing…

Forum Guide to Crime, Violence, and Discipline Incident Data. NFES 2011-806

ERIC Educational Resources Information Center

National Forum on Education Statistics, 2011

2011-01-01

This guide is designed for use by school, district, and state staff to improve the effectiveness of efforts to collect and use disciplinary incident data, including reporting accurate and timely incident data to the federal government. It provides recommendations on what types of data to collect, why it is critical to collect such data, and how to…

How School Facilities Managers and Business Officials Are Reducing Operating Costs and Saving Money. Energy-Smart Building Choices.

ERIC Educational Resources Information Center

Department of Energy, Washington, DC.

This guide addresses contributions that school facility administrators and business officials can make in an effort to reduce operating costs and free up money for capital improvements. The guide explores opportunities available to utilize energy-saving strategies at any stage in a building's life, from its initial design phase through renovation.…

Vocational Cosmetology: An Integrated Secondary-Post Secondary Curriculum Guide (Tentative).

ERIC Educational Resources Information Center

Utah State Board for Vocational Education, Salt Lake City.

This guide for Cosmetology is part of a public school effort to articulate secondary and post-secondary vocational education programs. It is organized in a pattern of behavioral objectives so that students may enter and complete the program in high school, or in a post-secondary program, or may transfer and continue without loss of time. Of the…

Counseling Services Resource Guide: An Internet Guide for the North Carolina Community College Counselor To Assist Virtual Learning Students.

ERIC Educational Resources Information Center

North Carolina Community Coll. System, Raleigh.

This handbook is intended to assist North Carolina community colleges in enhancing their online counseling services. Based on reviews of 58 community colleges in North Carolina, along with several state, national, and university web sites, and the collective efforts of a statewide committee, this handbook offers: (1) General tips for improving…

Punjabi Language and Culture: 9-Year Program Guide to Implementation, Grades 4-5-6

ERIC Educational Resources Information Center

Alberta Education, 2008

2008-01-01

This implementation guide is intended to support the Grade 4 to Grade 6 portion of the Punjabi Language and Culture Nine-Year Program (the program of studies.) It was developed primarily for teachers, yet it includes information that may be useful for administrators and other stakeholders in their efforts to plan for and implement the new Punjabi…

Cost Studies in Higher Education. The AIR Professional File, No. 7, Fall 1980.

ERIC Educational Resources Information Center

Hample, Stephen R.

A guide to cost studies in higher education is presented, with emphasis directed to the response of a four-year public institution to an externally mandated cost study. Cost studies are usually requested to guide budget allocations, either from an internal campus need or from outside pressures. Although much effort has been expended by various…

Procedures and Standards for Residential Ventilation System Commissioning: An Annotated Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stratton, J. Chris; Wray, Craig P.

2013-04-01

Beginning with the 2008 version of Title 24, new homes in California must comply with ANSI/ASHRAE Standard 62.2-2007 requirements for residential ventilation. Where installed, the limited data available indicate that mechanical ventilation systems do not always perform optimally or even as many codes and forecasts predict. Commissioning such systems when they are installed or during subsequent building retrofits is a step towards eliminating deficiencies and optimizing the tradeoff between energy use and acceptable IAQ. Work funded by the California Energy Commission about a decade ago at Berkeley Lab documented procedures for residential commissioning, but did not focus on ventilation systems.more » Since then, standards and approaches for commissioning ventilation systems have been an active area of work in Europe. This report describes our efforts to collect new literature on commissioning procedures and to identify information that can be used to support the future development of residential-ventilation-specific procedures and standards. We recommend that a standardized commissioning process and a commissioning guide for practitioners be developed, along with a combined energy and IAQ benefit assessment standard and tool, and a diagnostic guide for estimating continuous pollutant emission rates of concern in residences (including a database that lists emission test data for commercially-available labeled products).« less

Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery.

PubMed

Maciá-Vicente, Jose G; Shi, Yan-Ni; Cheikh-Ali, Zakaria; Grün, Peter; Glynou, Kyriaki; Kia, Sevda Haghi; Piepenbring, Meike; Bode, Helge B

2018-03-01

Fungi are prolific producers of natural products routinely screened for biotechnological applications, and those living endophytically within plants attract particular attention because of their purported chemical diversity. However, the harnessing of their biosynthetic potential is hampered by a large and often cryptic phylogenetic and ecological diversity, coupled with a lack of large-scale natural products' dereplication studies. To guide efforts to discover new chemistries among root-endophytic fungi, we analyzed the natural products produced by 822 strains using an untargeted UPLC-ESI-MS/MS-based approach and linked the patterns of chemical features to fungal lineages. We detected 17 809 compounds of which 7951 were classified in 1992 molecular families, whereas the remaining were considered unique chemistries. Our approach allowed to annotate 1191 compounds with different degrees of accuracy, many of which had known fungal origins. Approximately 61% of the compounds were specific of a fungal order, and differences were observed across lineages in the diversity and characteristics of their chemistries. Chemical profiles also showed variable chemosystematic values across lineages, ranging from relative homogeneity to high heterogeneity among related fungi. Our results provide an extensive resource to dereplicate fungal natural products and may assist future discovery programs by providing a guide for the selection of target fungi. © 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

Systems Engineering for Space Exploration Medical Capabilities

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Reilly, Jeffrey; Rubin, David; Urbina, Michelle; Hailey, Melinda; Hanson, Andrea; Burba, Tyler; McGuire, Kerry; Cerro, Jeffrey; Middour, Chris;

[Physical activity guidelines for Canadians: strategies for dissemination of the message, expectations for change and evaluation].

PubMed

Brawley, Lawrence R; Latimer, Amy E

2007-01-01

Physical activity guidelines offer evidence-based behavioural benchmarks that relate to reduced risk of morbidity and mortality if people adhere to them. Essentially, the guidelines tell people what to do, but not why and how they should do it. Thus, to motivate adherence, messages that translate guidelines should convey not only how much physical activity one should attempt and why it is recommended, but also how to achieve such a recommendation. Canada's physical activity guides exemplify how guidelines can be translated. This paper (i) provides a brief overview of the challenges encountered in creating the existing guides and (ii) highlights important practical issues and empirical evidence that should be considered in the future when translating guidelines into messages and disseminating these messages. We draw on the successes of past efforts to translate the goals of physical activity guidelines and on recent literature on messages and media campaigns to make recommendations. Information to motivate people to move toward the goals in physical activity guidelines should be translated into a set of messages that are informative, thought provoking, and persuasive. These messages should be disseminated to the public via a multi-phase social-marketing campaign that is carefully planned and thoroughly evaluated.

Towards interruption of schistosomiasis transmission in sub-Saharan Africa: developing an appropriate environmental surveillance framework to guide and to support 'end game' interventions.

PubMed

Stothard, J Russell; Campbell, Suzy J; Osei-Atweneboana, Mike Y; Durant, Timothy; Stanton, Michelle C; Biritwum, Nana-Kwadwo; Rollinson, David; Ombede, Dieudonné R Eloundou; Tchuem-Tchuenté, Louis-Albert

2017-01-14

Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa, particularly common in rural populations living in impoverished conditions. With the scale-up of preventive chemotherapy, national campaigns will transition from morbidity- to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as 'end game' scenarios arise. Surprisingly, there are no international or national guidelines to do so in sub-Saharan Africa. Our article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance framework. In this context, we discuss how strategies need to be adapted and tailored to the local level to better guide and support future interventions through this transition. As detection of egg-patent infection in people becomes rare, careful sampling of schistosome larvae in freshwater and in aquatic snails with robust species-specific DNA assays will be required. Appropriate metrics, derived from observed prevalence(s) as compared with predetermined thresholds, could each provide a clearer insight into contamination- and exposure-related dynamics. Application could be twofold, first to certify areas currently free from schistosomiasis transmission or second to red-flag recalcitrant locations where extra effort or alternative interventions are needed.

Do People Use the Shortest Path? An Empirical Test of Wardrop’s First Principle

PubMed Central

Zhu, Shanjiang; Levinson, David

2015-01-01

Most recent route choice models, following either the random utility maximization or rule-based paradigm, require explicit enumeration of feasible routes. The quality of model estimation and prediction is sensitive to the appropriateness of the consideration set. However, few empirical studies of revealed route characteristics have been reported in the literature. This study evaluates the widely applied shortest path assumption by evaluating routes followed by residents of the Minneapolis—St. Paul metropolitan area. Accurate Global Positioning System (GPS) and Geographic Information System (GIS) data were employed to reveal routes people used over an eight to thirteen week period. Most people did not choose the shortest path. Using three weeks of that data, we find that current route choice set generation algorithms do not reveal the majority of paths that individuals took. Findings from this study may guide future efforts in building better route choice models. PMID:26267756

POVME 2.0: An Enhanced Tool for Determining Pocket Shape and Volume Characteristics

PubMed Central

2015-01-01

Analysis of macromolecular/small-molecule binding pockets can provide important insights into molecular recognition and receptor dynamics. Since its release in 2011, the POVME (POcket Volume MEasurer) algorithm has been widely adopted as a simple-to-use tool for measuring and characterizing pocket volumes and shapes. We here present POVME 2.0, which is an order of magnitude faster, has improved accuracy, includes a graphical user interface, and can produce volumetric density maps for improved pocket analysis. To demonstrate the utility of the algorithm, we use it to analyze the binding pocket of RNA editing ligase 1 from the unicellular parasite Trypanosoma brucei, the etiological agent of African sleeping sickness. The POVME analysis characterizes the full dynamics of a potentially druggable transient binding pocket and so may guide future antitrypanosomal drug-discovery efforts. We are hopeful that this new version will be a useful tool for the computational- and medicinal-chemist community. PMID:25400521

Dasymetric high resolution population distribution estimates for improved decision making, with a case study of sea-level rise vulnerability in Boca Raton, Florida

NASA Astrophysics Data System (ADS)

Ziegler, Hannes Moritz

Planners and managers often rely on coarse population distribution data from the census for addressing various social, economic, and environmental problems. In the analysis of physical vulnerabilities to sea-level rise, census units such as blocks or block groups are coarse relative to the required decision-making application. This study explores the benefits offered from integrating image classification and dasymetric mapping at the household level to provide detailed small area population estimates at the scale of residential buildings. In a case study of Boca Raton, FL, a sea-level rise inundation grid based on mapping methods by NOAA is overlaid on the highly detailed population distribution data to identify vulnerable residences and estimate population displacement. The enhanced spatial detail offered through this method has the potential to better guide targeted strategies for future development, mitigation, and adaptation efforts.

Why are you telling me that? A conceptual model of the social function of autobiographical memory.

PubMed

Alea, Nicole; Bluck, Susan

2003-03-01

In an effort to stimulate and guide empirical work within a functional framework, this paper provides a conceptual model of the social functions of autobiographical memory (AM) across the lifespan. The model delineates the processes and variables involved when AMs are shared to serve social functions. Components of the model include: lifespan contextual influences, the qualitative characteristics of memory (emotionality and level of detail recalled), the speaker's characteristics (age, gender, and personality), the familiarity and similarity of the listener to the speaker, the level of responsiveness during the memory-sharing process, and the nature of the social relationship in which the memory sharing occurs (valence and length of the relationship). These components are shown to influence the type of social function served and/or, the extent to which social functions are served. Directions for future empirical work to substantiate the model and hypotheses derived from the model are provided.

Storytelling/narrative theory to address health communication with minority populations.

PubMed

Lee, Haeok; Fawcett, Jacqueline; DeMarco, Rosanna

2016-05-01

To explain the development and application of storytelling/narrative theory in health disparities intervention research as a way to promote health communication and behavior change among racial, ethnic, and minority populations. The proposed storytelling theory helps explain that storytelling affects changes in attitude and health behavior of the viewer through realism, identification, and transportation. The proposed storytelling/narrative theory can be a guide to develop culturally grounded narrative interventions that have the ability to connect with hard-to-reach populations. Narrative communication is context-dependent because it derives meaning from the surrounding situation and provides situation-based stories that are a pathway to processing story content. Although storytelling is grounded in nursing practice and education, it is underutilized in nursing interventional research. Future efforts are needed to extend theory-based narrative intervention studies designed to change attitude and behaviors that will reduce health disparities among minorities. Copyright © 2015 Elsevier Inc. All rights reserved.

The role of theory in research to develop and evaluate the implementation of patient safety practices.

PubMed

Foy, Robbie; Ovretveit, John; Shekelle, Paul G; Pronovost, Peter J; Taylor, Stephanie L; Dy, Sydney; Hempel, Susanne; McDonald, Kathryn M; Rubenstein, Lisa V; Wachter, Robert M

2011-05-01

Theories provide a way of understanding and predicting the effects of patient safety practices (PSPs), interventions intended to prevent or mitigate harm caused by healthcare or risks of such harm. Yet most published evaluations make little or no explicit reference to theory, thereby hindering efforts to generalise findings from one context to another. Theories from a wide range of disciplines are potentially relevant to research on PSPs. Theory can be used in research to explain clinical and organisational behaviour, to guide the development and selection of PSPs, and in evaluating their implementation and mechanisms of action. One key recommendation from an expert consensus process is that researchers should describe the theoretical basis for chosen intervention components or provide an explicit logic model for 'why this PSP should work.' Future theory-driven evaluations would enhance generalisability and help build a cumulative understanding of the nature of change.

Visualization and imaging methods for flames in microgravity

NASA Technical Reports Server (NTRS)

Weiland, Karen J.

1993-01-01

The visualization and imaging of flames has long been acknowledged as the starting point for learning about and understanding combustion phenomena. It provides an essential overall picture of the time and length scales of processes and guides the application of other diagnostics. It is perhaps even more important in microgravity combustion studies, where it is often the only non-intrusive diagnostic measurement easily implemented. Imaging also aids in the interpretation of single-point measurements, such as temperature, provided by thermocouples, and velocity, by hot-wire anemometers. This paper outlines the efforts of the Microgravity Combustion Diagnostics staff at NASA Lewis Research Center in the area of visualization and imaging of flames, concentrating on methods applicable for reduced-gravity experimentation. Several techniques are under development: intensified array camera imaging, and two-dimensional temperature and species concentrations measurements. A brief summary of results in these areas is presented and future plans mentioned.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goke, Sarah Hayes; Elliott, Nathan Ryan

The Sandia National Laboratories’ Internal Dosimetry Technical Basis Manual is intended to provide extended technical discussion and justification of the internal dosimetry program at SNL. It serves to record the approach to evaluating internal doses from radiobioassay data, and where appropriate, from workplace monitoring data per the Department of Energy Internal Dosimetry Program Guide DOE G 441.1C. The discussion contained herein is directed primarily to current and future SNL internal dosimetrists. In an effort to conserve space in the TBM and avoid duplication, it contains numerous references providing an entry point into the internal dosimetry literature relevant to this program.more » The TBM is not intended to act as a policy or procedure statement, but will supplement the information normally found in procedures or policy documents. The internal dosimetry program outlined in this manual is intended to meet the requirements of Federal Rule 10CFR835 for monitoring the workplace and for assessing internal radiation doses to workers.« less

Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.

PubMed

Miles, Rodney R; Shah, Rikin K; Frazer, J Kimble

2016-05-01

Molecular genetic abnormalities are ubiquitous in non-Hodgkin lymphoma (NHL), but genetic changes are not yet used to define specific lymphoma subtypes. Certain recurrent molecular genetic abnormalities in NHL underlie molecular pathogenesis and/or are associated with prognosis or represent potential therapeutic targets. Most molecular genetic studies of B- and T-NHL have been performed on adult patient samples, and the relevance of many of these findings for childhood, adolescent and young adult NHL remains to be demonstrated. In this review, we focus on NHL subtypes that are most common in young patients and emphasize features actually studied in younger NHL patients. This approach highlights what is known about NHL genetics in young patients but also points to gaps that remain, which will require cooperative efforts to collect and share biological specimens for genomic and genetic analyses in order to help predict outcomes and guide therapy in the future. © 2016 John Wiley & Sons Ltd.

The Design, Fabrication, and Testing of Composite Heat Exchange Coupons

NASA Technical Reports Server (NTRS)

Quade, Derek J.; Meador, Michael A.; Shin, Euy-Sik; Johnston, James C.; Kuczmarski, Maria A.

2011-01-01

Several heat exchanger (HX) test panels were designed, fabricated and tested at the NASA Glenn Research Center to explore the fabrication and performance of several designs for composite heat exchangers. The development of these light weight, high efficiency air-liquid test panels was attempted using polymer composites and carbon foam materials. The fundamental goal of this effort was to demonstrate the feasibility of the composite HX for various space exploration and thermal management applications including Orion CEV and Altair. The specific objectives of this work were to select optimum materials, designs, and to optimize fabrication procedures. After fabrication, the individual design concept prototypes were tested to determine their thermal performance and to guide the future development of full-size engineering development units (EDU). The overall test results suggested that the panel bonded with pre-cured composite laminates to KFOAM Grade L1 scored above the other designs in terms of ease of manufacture and performance.

CAN NONINVASIVE BRAIN STIMULATION ENHANCE COGNITION IN NEUROPSYCHIATRIC DISORDERS?

PubMed Central

Demirtas-Tatlidede, Asli; Vahabzadeh-Hagh, Andrew M.; Pascual-Leone, Alvaro

2013-01-01

Cognitive impairment is a core symptom of many neuropsychiatric diseases and a key contributor to the patient’s quality of life. However, an effective therapeutic strategy has yet to be developed. Noninvasive brain stimulation techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), are promising techniques that are under investigation for a variety of otherwise treatment-resistant neuropsychiatric diseases. Notably, these tools can induce alterations in neural networks subserving cognitive operations and thus may provide a means for cognitive restoration. The purpose of this article is to review the available evidence concerning cognitive enhancing properties of noninvasive brain stimulation in neuropsychiatry. We specifically focus on major depression, Alzheimer’s disease, schizophrenia, autism and attention deficit hyperactivity disorder (ADHD), where cognitive dysfunction is a major symptom and some studies have been completed with promising results. We provide a critical assessment of the available research and suggestions to guide future efforts. PMID:22749945

Behavioral development in embryonic and early juvenile cuttlefish (Sepia officinalis).

PubMed

O'Brien, Caitlin E; Mezrai, Nawel; Darmaillacq, Anne-Sophie; Dickel, Ludovic

2017-03-01

Though a mollusc, the cuttlefish Sepia officinalis possesses a sophisticated brain, advanced sensory systems, and a large behavioral repertoire. Cuttlefish provide a unique perspective on animal behavior due to their phylogenic distance from more traditional (vertebrate) models. S. officinalis is well-suited to addressing questions of behavioral ontogeny. As embryos, they can perceive and learn from their environment and experience no direct parental care. A marked progression in learning and behavior is observed during late embryonic and early juvenile development. This improvement is concomitant with expansion and maturation of the vertical lobe, the cephalopod analog of the mammalian hippocampus. This review synthesizes existing knowledge regarding embryonic and juvenile development in this species in an effort to better understand cuttlefish behavior and animal behavior in general. It will serve as a guide to future researchers and encourage greater awareness of the utility of this species to behavioral science. © 2016 Wiley Periodicals, Inc.

Safety impacts of bicycle infrastructure: A critical review.

PubMed

DiGioia, Jonathan; Watkins, Kari Edison; Xu, Yanzhi; Rodgers, Michael; Guensler, Randall

2017-06-01

This paper takes a critical look at the present state of bicycle infrastructure treatment safety research, highlighting data needs. Safety literature relating to 22 bicycle treatments is examined, including findings, study methodologies, and data sources used in the studies. Some preliminary conclusions related to research efficacy are drawn from the available data and findings in the research. While the current body of bicycle safety literature points toward some defensible conclusions regarding the safety and effectiveness of certain bicycle treatments, such as bike lanes and removal of on-street parking, the vast majority treatments are still in need of rigorous research. Fundamental questions arise regarding appropriate exposure measures, crash measures, and crash data sources. This research will aid transportation departments with regard to decisions about bicycle infrastructure and guide future research efforts toward understanding safety impacts of bicycle infrastructure. Copyright © 2017 Elsevier Ltd and National Safety Council. All rights reserved.

Exploring the zone of anisotropy and broken symmetries in DNA-mediated nanoparticle crystallization.

PubMed

O'Brien, Matthew N; Girard, Martin; Lin, Hai-Xin; Millan, Jaime A; Olvera de la Cruz, Monica; Lee, Byeongdu; Mirkin, Chad A

2016-09-20

In this work, we present a joint experimental and molecular dynamics simulations effort to understand and map the crystallization behavior of polyhedral nanoparticles assembled via the interaction of DNA surface ligands. In these systems, we systematically investigated the interplay between the effects of particle core (via the particle symmetry and particle size) and ligands (via the ligand length) on crystallization behavior. This investigation revealed rich phase diagrams, previously unobserved phase transitions in polyhedral crystallization behavior, and an unexpected symmetry breaking in the ligand distribution on a particle surface. To understand these results, we introduce the concept of a zone of anisotropy, or the portion of the phase space where the anisotropy of the particle is preserved in the crystallization behavior. Through comparison of the zone of anisotropy for each particle we develop a foundational roadmap to guide future investigations.

Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia.

PubMed

Gottesman, I I; Erlenmeyer-Kimling, L

2001-08-01

In an effort to share the experiences of 'genotype-hunters'-who have approached the difficult task of forecasting future schizophrenia in the young offspring or other relatives of index cases, in new samples guided by the prior probabilities of 15% in offspring or 50% in identical co-twins-with 'early-interventionists'-who focus on purported prodromal symptoms in children who would be treated pharmacologically to prevent the development of schizophrenia-we provide a focused review that emphasizes the hazards of false positives in both approaches. Despite the advantages prospective high-risk strategies have had from clinical and laboratory findings that implicate some prodromal signs and endophenotypes, e.g. attention, memory, and information processing evaluations, the yields are not sufficient for practical applications involving antipsychotic drugs for undiagnosed children. Even more caution than usual is required, given the suggestions that the developing neocortex is vulnerable to dopaminergic exposure.

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia.

PubMed

Grist, Eric P M; Flegg, Jennifer A; Humphreys, Georgina; Mas, Ignacio Suay; Anderson, Tim J C; Ashley, Elizabeth A; Day, Nicholas P J; Dhorda, Mehul; Dondorp, Arjen M; Faiz, M Abul; Gething, Peter W; Hien, Tran T; Hlaing, Tin M; Imwong, Mallika; Kindermans, Jean-Marie; Maude, Richard J; Mayxay, Mayfong; McDew-White, Marina; Menard, Didier; Nair, Shalini; Nosten, Francois; Newton, Paul N; Price, Ric N; Pukrittayakamee, Sasithon; Takala-Harrison, Shannon; Smithuis, Frank; Nguyen, Nhien T; Tun, Kyaw M; White, Nicholas J; Witkowski, Benoit; Woodrow, Charles J; Fairhurst, Rick M; Sibley, Carol Hopkins; Guerin, Philippe J

2016-10-24

Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently. The approach uses the 'uncertainty' map generated iteratively by a geostatistical model to determine optimal locations for subsequent sampling. The methodology is illustrated using recent data on the prevalence of the K13-propeller polymorphism (a genetic marker of artemisinin resistance) in the Greater Mekong Subregion. This methodology, which has broader application to geostatistical mapping in general, could improve the quality and efficiency of drug resistance mapping and thereby guide practical operations to eliminate malaria in affected areas.

Evaluation of a Participatory Ergonomics Intervention in Small Commercial Construction Firms

PubMed Central

Dale, Ann Marie; Jaegers, Lisa; Welch, Laura; Gardner, Bethany T.; Buchholz, Bryan; Weaver, Nancy; Evanoff, Bradley A.

2017-01-01

Background Work-related musculoskeletal disorders (WMSD) among construction workers remain high. Participatory ergonomics (PE) interventions that engage workers and employers in reducing work injury risks have shown mixed results. Methods Eight-six workers from seven contractors participated in a PE program. A logic model guided the process evaluation and summative evaluation of short term and intermediate impacts and long term outcomes from surveys and field records. Results Process measures showed good delivery of training, high worker engagement, and low contractor participation. Workers’ knowledge improved and workers reported changes to work practices and tools used; contractor provision of appropriate equipment was low (33%). No changes were seen in symptoms or reported physical effort. Conclusions The PE program produced many worker-identified ergonomic solutions, but lacked needed support from contractors. Future interventions should engage higher levels of the construction organizational system to improve contractor involvement for reducing WMSD. PMID:27094450

An academic approach to climate change emergency preparedness.

PubMed

Trask, Jeffrey A

To achieve effective emergency management and business continuity, all hazards should be considered during the planning and preparedness process. In recent years, several new hazards have attracted the attention of Emergency Management and Business Continuity practitioners. Climate change presents a unique challenge. Practitioners must rely on historical data combined with scientific projections to guide their planning and preparedness efforts. This article examines how an academic institution's emergency management programme can plan successfully for this hazard by focusing on best practices in the area of building cross-departmental and cross-jurisdictional relationships. Examples of scientific data related to the hazard of climate change will be presented along with the latest guidance from the Federal Emergency Management Agency encouraging the planning for future hazards. The article presents a functional exercise in which this hazard was prominently featured, and presents testimony from subject matter experts. Recommendations for emergency management and business continuity programmes are so provided.

Impact of Environment on the Biomass Composition of Soybean (Glycine max) seeds.

PubMed

McClure, Tamara; Cocuron, Jean-Christophe; Osmark, Veronika; McHale, Leah K; Alonso, Ana Paula

2017-08-16

Factors including genetics, fertilization, and climatic conditions, can alter the biomass composition of soybean seeds, consequently impacting their market value and usage. This study specifically determined the content of protein and oil, as well as the composition of proteinogenic amino acids and fatty acids in seeds from 10 diverse soybean cultivars grown in four different sites. The results highlighted that different environments produce a different composition for the 10 cultivars under investigation. Specifically, the levels of oleic and linoleic acids, important contributors to oil stability, were negatively correlated. Although the protein and oil contents were higher in some locations, their "quality" was lower in terms of composition of essential amino acids and oleic acid, respectively. Finally, proteinogenic histidine and glutamate were the main contributors to the separation between Central and Northern growing sites. Taken together, these results can guide future breeding and engineering efforts aiming to develop specialized soybean lines.

Approaches to Understanding and Addressing Treatment-Resistant Depression: A Scoping Review

PubMed Central

Jenkins, Emily; Goldner, Elliot M.

2012-01-01

Treatment-resistant depression is associated with significant disability and, due to its high prevalence, results in substantive economic and societal burden at a population level. The objective of this study is to synthesize extant literature on approaches currently being applied to understand and address this condition. It is hoped that the findings can be used to inform practitioners and guide future research. A scoping review of the scientific literature was conducted with findings categorized and charted by underlying research paradigm. Currently, the vast majority of research stems from a biological paradigm (81%). Research on treatment-resistant depression would benefit from a broadened field of study. Given that multiple etiological mechanisms likely contribute to treatment-resistant depression and current efforts at prevention and treatment have substantial room for improvement, an expanded research agenda could more effectively address this significant public health issue. PMID:22570778

Overcoming Hurdles: Teaching Guides To Interpret Biodiversity Conservation.

ERIC Educational Resources Information Center

Kohl, Jon; Brown, Cynthia; Humke, Matt

2001-01-01

Highlights the development and use of bilingual nature guide training. Examines work at the RARE Center for tropical conservation in Central America. Speculates about the future of conservation interpretation. (DDR)

Transportation Acronym Guide, 1994

DOT National Transportation Integrated Search

1994-11-01

This report compiles and identifies transportation and transportation-related acronyms throughout the Department of Transportation and other related U.S. government agencies. This is the second edition of the Transportation Acronym Guide (TAG); futur...

Transportation Acronym Guide, 1996

DOT National Transportation Integrated Search

1996-06-01

This report compiles and identifies transportation and transportation-related acronyms throughout the Department of Transportation and other related U.S. government agencies. This is the second edition of the Transportation Acronym Guide (TAG); futur...

Space Shuttle main engine OPAD: The search for a hardware enhanced plume

NASA Astrophysics Data System (ADS)

Powers, W. T.; Cooper, A. E.; Wallace, Tim L.; Buntine, W. L.; Whitaker, K. W.

1993-11-01

The process of applying spectroscopy to the Space Shuttle Main Engine (SSME) for plume diagnostics, as it exists today, originated at Marshall Space Flight Center in Huntsville, Alabama, and its implementation was assured largely through the efforts of Sverdrup AEDC, in Tullahoma, Tennessee. This team continues to lead and guide efforts in the plume diagnostics arena. The process, Optical Plume Anomaly Detection (OPAD), formed the basis for various activities in the development of ground-based systems as well as the development of in-flight plume spectroscopy. OPAD currently provides and will continue to provide valuable information relative to future systems definitions, instrumentation development, code validation, and data diagnostic processing. OPAD is based on the detection of anomalous atomic and molecular species in the SSME plume using two complete, stand-alone optical spectrometers. To-date OPAD has acquired data on 44 test firings of the SSME at the Technology Test Bed (TTB) at MSFC. The purpose of this paper will be to provide an introduction to the OPAD system by discussing the process of obtaining data as well as the methods of examining and interpreting the data. It will encompass such issues as selection of instrumentation correlation of data to nominal engine operation, investigation of SSME component erosion via OPAD spectral data, necessity and benefits of plume seeding, application of artificial intelligence (AI) techniques to data analysis, and the present status of efforts to quantify specie erosion utilizing standard plume and chemistry codes as well as radiative models currently under development.

Constructing a Shared Mental Model for Faculty Development for the Core Entrustable Professional Activities for Entering Residency.

PubMed

Favreau, Michele A; Tewksbury, Linda; Lupi, Carla; Cutrer, William B; Jokela, Janet A; Yarris, Lalena M

2017-06-01

In 2014, the Association of American Medical Colleges identified 13 Core Entrustable Professional Activities for Entering Residency (Core EPAs), which are activities that entering residents might be expected to perform without direct supervision. This work included the creation of an interinstitutional concept group focused on faculty development efforts, as the processes and tools for teaching and assessing entrustability in undergraduate medical education (UME) are still evolving. In this article, the authors describe a conceptual framework for entrustment that they developed to better prepare all educators involved in entrustment decision making in UME. This framework applies to faculty with limited or longitudinal contact with medical students and to those who contribute to entrustment development or render summative entrustment decisions.The authors describe a shared mental model for entrustment that they developed, based on a critical synthesis of the EPA literature, to serve as a guide for UME faculty development efforts. This model includes four dimensions for Core EPA faculty development: (1) observation skills in authentic settings (workplace-based assessments), (2) coaching and feedback skills, (3) self-assessment and reflection skills, and (4) peer guidance skills developed through a community of practice. These dimensions form a conceptual foundation for meaningful faculty participation in entrustment decision making.The authors also differentiate between the UME learning environment and the graduate medical education learning environment to highlight distinct challenges and opportunities for faculty development in UME settings. They conclude with recommendations and research questions for future Core EPA faculty development efforts.

Space Shuttle main engine OPAD: The search for a hardware enhanced plume

NASA Technical Reports Server (NTRS)

Powers, W. T.; Cooper, A. E.; Wallace, Tim L.; Buntine, W. L.; Whitaker, K. W.

1993-01-01

The process of applying spectroscopy to the Space Shuttle Main Engine (SSME) for plume diagnostics, as it exists today, originated at Marshall Space Flight Center in Huntsville, Alabama, and its implementation was assured largely through the efforts of Sverdrup AEDC, in Tullahoma, Tennessee. This team continues to lead and guide efforts in the plume diagnostics arena. The process, Optical Plume Anomaly Detection (OPAD), formed the basis for various activities in the development of ground-based systems as well as the development of in-flight plume spectroscopy. OPAD currently provides and will continue to provide valuable information relative to future systems definitions, instrumentation development, code validation, and data diagnostic processing. OPAD is based on the detection of anomalous atomic and molecular species in the SSME plume using two complete, stand-alone optical spectrometers. To-date OPAD has acquired data on 44 test firings of the SSME at the Technology Test Bed (TTB) at MSFC. The purpose of this paper will be to provide an introduction to the OPAD system by discussing the process of obtaining data as well as the methods of examining and interpreting the data. It will encompass such issues as selection of instrumentation correlation of data to nominal engine operation, investigation of SSME component erosion via OPAD spectral data, necessity and benefits of plume seeding, application of artificial intelligence (AI) techniques to data analysis, and the present status of efforts to quantify specie erosion utilizing standard plume and chemistry codes as well as radiative models currently under development.

Energy Efficiency Measures to Incorporate into Remodeling Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liaukus, C.

2014-12-01

Energy improvements in a home are often approached as one concerted effort, beginning with a simple walk-through assessment or more in-depth energy audit and followed by the installation of recommended energy measures. While this approach allows for systems thinking to guide the efforts, comprehensive energy improvements of this nature are undertaken by a relatively small number of the households in our nation compared to more piecemeal remodeling efforts. Even when programs like the Weatherization Assistance Program and Home Performance with ENERGY STAR are considered, homes that have had a comprehensive energy makeover still represent a small fraction of the 111.1more » million households. In this report, the U.S Department of Energy Building America Retrofit Alliance research team looks at the improvement of a home's energy performance in an opportunistic way: it examines what can be done to incorporate energy efficiency measures into general remodeling work and home repair projects. This allows for the possibility for people who would not normally pursue energy efficiency but will remodel their kitchen or re-side their home to improve their home's performance at the same time. There are challenges to this approach, not the least of which being that the work will take place over time in potentially many separate projects. The opportunity to improve a home's energy efficiency at one time expands or contracts with the scope of the remodel. As such, guidance on how to do each piece thoughtfully and with consideration for potential future projects, is critical.« less

Pathways to Problem Behaviors: Chaotic Homes, Parent and Child Effortful Control, and Parenting

ERIC Educational Resources Information Center

Valiente, Carlos; Lemery-Chalfant, Kathryn; Reiser, Mark

2007-01-01

Guided by Belsky's and Eisenberg, Cumberland, and Spinrad's heuristic models, we tested a process model with hypothesized paths from parents' effortful control (EC) and family chaos to indices of parenting to children's EC, and finally children's externalizing problem behavior. Parents reported on all constructs and children (N = 188; M age = 9.55…

Faculty Opinions Regarding the Philosophical Principles of Total Quality Management (TQM).

ERIC Educational Resources Information Center

Aliff, John Vincent

The 14 points of the Total Quality Management (TQM) model can be distilled into the following 5 main guiding principles: establish a moral purpose for the institution, use cooperative efforts instead of individual efforts, stop the use of inspection (testing) to improve students and teachers, continuously improve the system and its products, and…

Choices in Little Rock. A Facing History and Ourselves Teaching Guide

ERIC Educational Resources Information Center

Facing History and Ourselves, 2005

2005-01-01

This book presents a teaching unit that focuses on efforts to desegregate Central High School in Little Rock, Arkansas, in 1957--efforts that resulted in a crisis that historian Taylor Branch once described as "the most severe test of the Constitution since the Civil War." The unit explores civic choices--the decisions people make as…

Managing Your Money. Leader's Guide [and] Participant's Workbook.

ERIC Educational Resources Information Center

Nieuwenhuis, Ann; Hathaway, Irene

This document contains both a leader's guide and participant's workbook on money management. The leader's and participant's guides contain 10 parts each: (1) danger signs in money management; (2) what's important to you; (3) spending for the future; (4) financial fitness; (5) use credit wisely; (6) decisions, decisions; (7) shopping basics; (8)…

77 FR 29351 - Disease, Disability, and Injury Prevention and Control; Special Interest Projects (SIPs): Initial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

... Indoor Tanning among Young Adults to Inform Future Public Health Policy Efforts to Prevent Skin Cancer... Frequent Indoor Tanning among Young Adults to Inform Future Public Health Policy Efforts to Prevent Skin...

Abandoned babies and absent policies.

PubMed

Mueller, Joanne; Sherr, Lorraine

2009-12-01

Although infant abandonment is a historical problem, we know remarkably little about the conditions or effects of abandonment to guide evidence driven policies. This paper briefly reviews the existing international evidence base with reference to potential mental health considerations before mapping current UK guidelines and procedures, and available incidence data. Limitations arising from these findings are discussed with reference to international practice, and interpreted in terms of future pathways for UK policy. A systematic approach was utilized to gather available data on policy information and statistics on abandoned babies in the UK. A review of the limited literature indicates that baby abandonment continues to occur, with potentially wide-ranging mental health ramifications for those involved. However, research into such consequences is lacking, and evidence with which to understand risk factors or motives for abandonment is scarce. International approaches to the issue remain controversial with outcomes unclear. Our systematic search identified that no specific UK policy relating to baby abandonment exists, either nationally or institutionally. This is compounded by a lack of accurate of UK abandonment statistics. Data that does exist is not comprehensive and sources are incompatible, resulting in an ambiguous picture of UK baby abandonment. Available literature indicates an absence of clear provision, policy and research on baby abandonment. Based on current understanding of maternal and child mental health issues likely to be involved in abandonment, existing UK strategy could be easily adapted to avoid the 'learning from scratch' approach. National policies on recording and handling of baby abandonments are urgently needed, and future efforts should be concentrated on establishing clear data collection frameworks to inform understanding, guide competent practice and enable successfully targeted interventions.

Ground water flow modeling with sensitivity analyses to guide field data collection in a mountain watershed

USGS Publications Warehouse

Johnson, Raymond H.

2007-01-01

In mountain watersheds, the increased demand for clean water resources has led to an increased need for an understanding of ground water flow in alpine settings. In Prospect Gulch, located in southwestern Colorado, understanding the ground water flow system is an important first step in addressing metal loads from acid-mine drainage and acid-rock drainage in an area with historical mining. Ground water flow modeling with sensitivity analyses are presented as a general tool to guide future field data collection, which is applicable to any ground water study, including mountain watersheds. For a series of conceptual models, the observation and sensitivity capabilities of MODFLOW-2000 are used to determine composite scaled sensitivities, dimensionless scaled sensitivities, and 1% scaled sensitivity maps of hydraulic head. These sensitivities determine the most important input parameter(s) along with the location of observation data that are most useful for future model calibration. The results are generally independent of the conceptual model and indicate recharge in a high-elevation recharge zone as the most important parameter, followed by the hydraulic conductivities in all layers and recharge in the next lower-elevation zone. The most important observation data in determining these parameters are hydraulic heads at high elevations, with a depth of less than 100 m being adequate. Evaluation of a possible geologic structure with a different hydraulic conductivity than the surrounding bedrock indicates that ground water discharge to individual stream reaches has the potential to identify some of these structures. Results of these sensitivity analyses can be used to prioritize data collection in an effort to reduce time and money spend by collecting the most relevant model calibration data.

Global research priorities to mitigate plastic pollution impacts on marine wildlife

USGS Publications Warehouse

Vegter, Amanda C.; Barletta, Mário; Beck, Cathy A.; Borrero, Jose C.; Burton, Harry; Campbell, Marnie L.; Costa, Monica F.; Eriksen, Marcus; Eriksson, Cecilia; Estrades, Andres; Gilardi, Kirsten V.; Hardesty, Britta D.; do Sul, Juliana A. Ivar; Lavers, Jennifer L.; Lazar, Bojan; Lebreton, Laurent; Nichols, Wallace J.; Ribic, Christine A.; Ryan, Peter G.; Schuyler, Qamar A.; Smith, Stephen D. A.; Takada, Hideshige; Townsend, Kathy A.; Wabnitz, Colette C. C.; Wilcox, Chris; Young, Lindsay C.; Hamann, Mark

2014-01-01

Marine wildlife faces a growing number of threats across the globe, and the survival of many species and populations will be dependent on conservation action. One threat in particular that has emerged over the last 4 decades is the pollution of oceanic and coastal habitats with plastic debris. The increased occurrence of plastics in marine ecosystems mirrors the increased prevalence of plastics in society, and reflects the high durability and persistence of plastics in the environment. In an effort to guide future research and assist mitigation approaches to marine conservation, we have generated a list of 16 priority research questions based on the expert opinions of 26 researchers from around the world, whose research expertise spans several disciplines, and covers each of the world’s oceans and the taxa most at risk from plastic pollution. This paper highlights a growing concern related to threats posed to marine wildlife from microplastics and fragmented debris, the need for data at scales relevant to management, and the urgent need to develop interdisciplinary research and management partnerships to limit the release of plastics into the environment and curb the future impacts of plastic pollution.

Adaptive harvest management of North American waterfowl populations - recent successes and future prospects

USGS Publications Warehouse

Nichols, J.D.; Runge, M.C.; Johnson, F.A.; Williams, B.K.; Schodde, Richard; Hannon, Susan; Scheiffarth, Gregor; Bairlein, Franz

2006-01-01

The history of North American waterfowl harvest management has been characterized by attempts to use population monitoring data to make informed harvest management decisions. Early attempts can be characterized as intuitive decision processes, and later efforts were guided increasingly by population models and associated predictions. In 1995, a formal adaptive management process was implemented, and annual decisions about duck harvest regulations in the United States are still based on this process. This formal decision process is designed to deal appropriately with the various forms of uncertainty that characterize management decisions, environmental uncertainty, structural uncertainty, partial controllability and partial observability. The key components of the process are (1) objectives, (2) potential management actions, (3) model(s) of population response to management actions, (4) credibility measures for these models, and (5) a monitoring program. The operation of this iterative process is described, and a brief history of a decade of its use is presented. Future challenges range from social and political issues such as appropriate objectives and management actions, to technical issues such as multispecies management, geographic allocation of harvest, and incorporation of actions that include habitat acquisition and management.

Fusion proteins in head and neck neoplasms: Clinical implications, genetics, and future directions for targeting

PubMed Central

Escalante, Derek A.; Wang, He; Fundakowski, Christopher E.

2016-01-01

ABSTRACT Fusion proteins resulting from chromosomal rearrangements are known to drive the pathogenesis of a variety of hematological and solid neoplasms such as chronic myeloid leukemia and non-small-cell lung cancer. Efforts to elucidate the role they play in these malignancies have led to important diagnostic and therapeutic triumphs, including the famous development of the tyrosine kinase inhibitor dasatinib targeting the BCR-ABL fusion. Until recently, there has been a paucity of research investigating fusion proteins harbored by head and neck neoplasms. The discovery and characterization of novel fusion proteins in neoplasms originating from the thyroid, nasopharynx, salivary glands, and midline head and neck structures offer substantial contributions to our understanding of the pathogenesis and biological behavior of these neoplasms, while raising new therapeutic and diagnostic opportunities. Further characterization of these fusion proteins promises to facilitate advances on par with those already achieved with regard to hematologic malignancies in the precise, molecularly guided diagnosis and treatment of head and neck neoplasms. The following is a subsite specific review of the clinical implications of fusion proteins in head and neck neoplasms and the future potential for diagnostic targeting. PMID:27636353

Frontiers in research on biodiversity and disease.

PubMed

Johnson, Pieter T J; Ostfeld, Richard S; Keesing, Felicia

2015-10-01

Global losses of biodiversity have galvanised efforts to understand how changes to communities affect ecological processes, including transmission of infectious pathogens. Here, we review recent research on diversity-disease relationships and identify future priorities. Growing evidence from experimental, observational and modelling studies indicates that biodiversity changes alter infection for a range of pathogens and through diverse mechanisms. Drawing upon lessons from the community ecology of free-living organisms, we illustrate how recent advances from biodiversity research generally can provide necessary theoretical foundations, inform experimental designs, and guide future research at the interface between infectious disease risk and changing ecological communities. Dilution effects are expected when ecological communities are nested and interactions between the pathogen and the most competent host group(s) persist or increase as biodiversity declines. To move beyond polarising debates about the generality of diversity effects and develop a predictive framework, we emphasise the need to identify how the effects of diversity vary with temporal and spatial scale, to explore how realistic patterns of community assembly affect transmission, and to use experimental studies to consider mechanisms beyond simple changes in host richness, including shifts in trophic structure, functional diversity and symbiont composition. © 2015 John Wiley & Sons Ltd/CNRS.

The military health system: a community of solutions for medical education, health care delivery, and public health.

PubMed

Lennon, Robert P; Saguil, Aaron; Seehusen, Dean A; Reamy, Brian V; Stephens, Mark B

2013-01-01

Multiple strategies have been proposed to improve health care in the United States. These include the development of communities of solution (COSs), implementation of patient-centered medical homes (PCMHs), and lengthening family medicine residency training. There is scant literature on how to build and integrate these ideal models of care, and no literature about how to build a model of care integrating all 3 strategies is available. The Military Health System has adopted the PCMH model and will offer some 4-year family medicine residency positions starting in 2013. Lengthening residency training to 4 years represents an unprecedented opportunity to weave experiential COS instruction throughout a family physician's graduate medical education, providing future family physicians the skills needed to foster a COS in their future practice. This article describes our COS effort to synergize 3 aspects of modern military medicine: self-defined community populations, the transition to the PCMH model, and the initiation of the 4-year length of training pilot program in family medicine residency training. In this way we provide a starting point and general how-to guide that can be used to create a COS integrated with other current concepts in medicine.

A 1,574-Day Periodicity of Transits Orbiting KIC 8462852

NASA Astrophysics Data System (ADS)

Sacco, G.; Ngo, L. D.; Modolo, J.

2018-06-01

Observations of the main sequence F3V star KIC 8462852 (also known as Boyajianís star) revealed extreme aperiodic dips in flux up to 20% during the four years of the Kepler mission. Smaller dips (< 3%) were also observed with ground-based telescopes between May 2017 and May 2018. We investigated possible correlation between recent dips and the major dips in the last 100 days of the Kepler mission. We compared Kepler light curve data, 2017 data from two observatories (TFN, OGG) which are part of the Las Cumbres Observatory (LCO) network, as well as archival data from the Harvard College Observatory (HCO), Sonneberg Observatory, and Sternberg Observatory, and determined that observations appear consistent with a 1,574-day (4.31-year) periodicity of a transit (or group of transits) orbiting Boyajianís star within the habitable zone. Comparison with future observations is required to validate this hypothesis. Furthermore, it is unknown if transits that have produced other major dips as observed during the Kepler mission (e.g. D792) share the same orbital period. Nevertheless, the proposed periodicity is a step forward in guiding future observation efforts.

A legacy building model for holistic nursing.

PubMed

Lange, Bernadette; Zahourek, Rothlyn P; Mariano, Carla

2014-06-01

This pilot project was an effort to record the historical roots, development, and legacy of holistic nursing through the visionary spirit of four older American Holistic Nurses Association (AHNA) members. The aim was twofold: (a) to capture the holistic nursing career experiences of elder AHNA members and (b) to begin to create a Legacy Building Model for Holistic Nursing. The narratives will help initiate an ongoing, systematic method for the collection of historical data and serve as a perpetual archive of knowledge and inspiration for present and future holistic nurses. An aesthetic inquiry approach was used to conduct in-depth interviews with four older AHNA members who have made significant contributions to holistic nursing. The narratives provide a rich description of their personal and professional evolution as holistic nurses. The narratives are presented in an aesthetic format of the art forms of snapshot, pastiche, and collage rather than traditional presentations of research findings. A synopsis of the narratives is a dialogue between the three authors and provides insight for how a Legacy Model can guide our future. Considerations for practice, education, and research are discussed based on the words of wisdom from the four older holistic nurses.

Frontiers in research on biodiversity and disease

PubMed Central

Johnson, Pieter T. J.; Ostfeld, Richard S.; Keesing, Felicia

2016-01-01

Global losses of biodiversity have galvanised efforts to understand how changes to communities affect ecological processes, including transmission of infectious pathogens. Here, we review recent research on diversity–disease relationships and identify future priorities. Growing evidence from experimental, observational and modelling studies indicates that biodiversity changes alter infection for a range of pathogens and through diverse mechanisms. Drawing upon lessons from the community ecology of free-living organisms, we illustrate how recent advances from biodiversity research generally can provide necessary theoretical foundations, inform experimental designs, and guide future research at the interface between infectious disease risk and changing ecological communities. Dilution effects are expected when ecological communities are nested and interactions between the pathogen and the most competent host group(s) persist or increase as biodiversity declines. To move beyond polarising debates about the generality of diversity effects and develop a predictive framework, we emphasise the need to identify how the effects of diversity vary with temporal and spatial scale, to explore how realistic patterns of community assembly affect transmission, and to use experimental studies to consider mechanisms beyond simple changes in host richness, including shifts in trophic structure, functional diversity and symbiont composition. PMID:26261049

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

PubMed Central

Chen, Lieping; Han, Xue

2015-01-01

Major progress has been made toward our understanding of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway (referred to as the PD pathway). mAbs are already being used to block the PD pathway to treat human cancers (anti-PD therapy), especially advanced solid tumors. This therapy is based on principles that were discovered through basic research more than a decade ago, but the great potential of this pathway to treat a broad spectrum of advanced human cancers is just now becoming apparent. In this Review, we will briefly review the history and development of anti-PD therapy, from the original benchwork to the most up-to-date clinical results. We will then focus the discussion on three basic principles that define this unique therapeutic approach and highlight how anti-PD therapy is distinct from other immunotherapeutic approaches, namely tumor site immune modulation, targeting tumor-induced immune defects, and repairing ongoing (rather than generating de novo) tumor immunity. We believe that these fundamental principles set the standard for future immunotherapies and will guide our efforts to develop more efficacious and less toxic immune therapeutics to treat human cancers. PMID:26325035

Comparison of mechanical energy profiles of passive and active below-knee prostheses: a case study.

PubMed

Takahashi, Kota Z; Horne, John R; Stanhope, Steven J

2015-04-01

With the recent technological advancements of prosthetic lower limbs, there is currently a great desire to objectively evaluate existing prostheses. Using a novel biomechanical analysis, the purpose of this case study was to compare the mechanical energy profiles of anatomical and two disparate prostheses: a passive prosthesis and an active prosthesis. An individual with a transtibial amputation who customarily wears a passive prosthesis (Elation, Össur) and an active prosthesis (BiOM, iWalk, Inc.) and 11 healthy subjects participated in an instrumented gait analysis. The total mechanical power and work of below-knee structures during stance were quantified using a unified deformable segment power analysis. Active prosthesis generated greater peak power and total positive work than passive prosthesis and healthy anatomical limbs. The case study will enhance future efforts to objectively evaluate prosthetic functions during gait in individuals with transtibial amputations. A prosthetic limb should closely replicate the mechanical energy profiles of anatomical limbs. The unified deformable (UD) analysis may be valuable to facilitate future clinical prescription and guide fine adjustments of prosthetic componentry to optimize gait outcomes. © The International Society for Prosthetics and Orthotics 2014.

Border Environmental Education Resource Guide: Southern New Mexico, South Texas, Northern Chihuahua, Northern Coahuila, Northern Nuevo Leon, Northern Tamaulipas = Guia de Recursos de Educacion Ambiental en la Frontera: Sur de Nuevo Mexico, Sur de Texas, Norte de Chihuahua, Norte de Coahuila, Norte de Nuevo Leon, Norte de Tamaulipas.

ERIC Educational Resources Information Center

Meissner, David, Comp.

This guide provides educators and residents of the border with useful information about environmental education program offerings along the eastern half of the United States-Mexico border. The programs listed in the guide represent a broad range of educational efforts focused on understanding the environment and solving environmental problems in…

Tensoral for post-processing users and simulation authors

NASA Technical Reports Server (NTRS)

Dresselhaus, Eliot

1993-01-01

The CTR post-processing effort aims to make turbulence simulations and data more readily and usefully available to the research and industrial communities. The Tensoral language, which provides the foundation for this effort, is introduced here in the form of a user's guide. The Tensoral user's guide is presented in two main sections. Section one acts as a general introduction and guides database users who wish to post-process simulation databases. Section two gives a brief description of how database authors and other advanced users can make simulation codes and/or the databases they generate available to the user community via Tensoral database back ends. The two-part structure of this document conforms to the two-level design structure of the Tensoral language. Tensoral has been designed to be a general computer language for performing tensor calculus and statistics on numerical data. Tensoral's generality allows it to be used for stand-alone native coding of high-level post-processing tasks (as described in section one of this guide). At the same time, Tensoral's specialization to a minute task (namely, to numerical tensor calculus and statistics) allows it to be easily embedded into applications written partly in Tensoral and partly in other computer languages (here, C and Vectoral). Embedded Tensoral, aimed at advanced users for more general coding (e.g. of efficient simulations, for interfacing with pre-existing software, for visualization, etc.), is described in section two of this guide.

Governance: The Mission Ingredient in Security Cooperation

DTIC Science & Technology

2017-06-09

assistance guiding principle of “do-no-harm,” should be included in the future DOS guidance. Seven do-no-harm lessons include: (1) norms and... principle of “do-no-harm.” 15. SUBJECT TERMS Security cooperation, security assistance, defense institution building, USAID, best practices...foreign assistance guiding principle of “do-no-harm,” should be included in the future DOS guidance. Seven do-no-harm lessons include: (1) norms and

Opioid analgesics and heroin: Examining drug misuse trends among a sample of drug treatment clients in Kentucky.

PubMed

Victor, Grant A; Walker, Robert; Cole, Jennifer; Logan, T K

2017-08-01

In an effort to mitigate Kentucky's prescription drug misuse, legislative intervention efforts were introduced in 2012 and 2013 to better regulate pain clinics, prescribed use of opioid analgesics, and to expand the monitoring of opioid prescriptions. The focus of this paper is primarily on opioid analgesics and heroin and the relationship of use/misuse patterns of these drugs to state drug policy initiatives. A secondary data analysis of drug treatment clients (N=52,360) was conducted to project illicit drug use trends in Kentucky. This study describes temporal and geographic trends of self-reported illicit drug use among individuals in state-funded treatment in Kentucky between fiscal year 2010 and fiscal year 2013. Significant reductions in the prevalence of illicit opioid use, declined from fiscal year 2010 to fiscal year 2013 (p<.01, CI=-.298 to -.215). However, heroin use rates significantly increased over the years studied, suggesting there may be a transition from prescription opioids to heroin (p<.01, CI=.143 to .178). The analysis suggests these trends may continue. Findings suggest Kentucky's legislative efforts were effective in reducing illicit prescription opioid use, but heroin use has increased. One possible explanation for this relationship is that as prescription opioids became more difficult to obtain, users turned to heroin as a substitute. The finding of rising heroin use suggests a need for further policy initiatives to reduce heroin use, but the potential effectiveness of this policy remains unclear. Understanding trends may help to guide future policy efforts and pain management treatment strategies to where they might have their greatest impact. Copyright © 2017 Elsevier B.V. All rights reserved.

Lessons learned from a health record bank start-up.

PubMed

Yasnoff, W A; Shortliffe, E H

2014-01-01

This article is part of a Focus Theme of METHODS of Information in Medicine on Health Record Banking. In late summer 2010, an organization was formed in greater Phoenix, Arizona (USA), to introduce a health record bank (HRB) in that community. The effort was initiated after market research and was aimed at engaging 200,000 individuals as members in the first year (5% of the population). It was also intended to evaluate a business model that was based on early adoption by consumers and physicians followed by additional revenue streams related to incremental services and secondary uses of clinical data, always with specific permission from individual members, each of whom controlled all access to his or her own data. To report on the details of the HRB experience in Phoenix, to describe the sources of problems that were experienced, and to identify lessons that need to be considered in future HRB ventures. We describe staffing for the HRB effort, the computational platform that was developed, the approach to marketing, the engagement of practicing physicians, and the governance model that was developed to guide the HRB design and implementation. Despite efforts to engage the physician community, limited consumer advertising, and a carefully considered financial strategy, the experiment failed due to insufficient enrollment of individual members. It was discontinued in April 2011. Although the major problem with this HRB project was undercapitalization, we believe this effort demonstrated that basic HRB accounts should be free for members and that physician engagement and participation are key elements in constructing an effective marketing channel. Local community governance is essential for trust, and the included population must be large enough to provide sufficient revenues to sustain the resource in the long term.

SHARP pre-release v1.0 - Current Status and Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahadevan, Vijay S.; Rahaman, Ronald O.

The NEAMS Reactor Product Line effort aims to develop an integrated multiphysics simulation capability for the design and analysis of future generations of nuclear power plants. The Reactor Product Line code suite’s multi-resolution hierarchy is being designed to ultimately span the full range of length and time scales present in relevant reactor design and safety analyses, as well as scale from desktop to petaflop computing platforms. In this report, building on a several previous report issued in September 2014, we describe our continued efforts to integrate thermal/hydraulics, neutronics, and structural mechanics modeling codes to perform coupled analysis of a representativemore » fast sodium-cooled reactor core in preparation for a unified release of the toolkit. The work reported in the current document covers the software engineering aspects of managing the entire stack of components in the SHARP toolkit and the continuous integration efforts ongoing to prepare a release candidate for interested reactor analysis users. Here we report on the continued integration effort of PROTEUS/Nek5000 and Diablo into the NEAMS framework and the software processes that enable users to utilize the capabilities without losing scientific productivity. Due to the complexity of the individual modules and their necessary/optional dependency library chain, we focus on the configuration and build aspects for the SHARP toolkit, which includes capability to autodownload dependencies and configure/install with optimal flags in an architecture-aware fashion. Such complexity is untenable without strong software engineering processes such as source management, source control, change reviews, unit tests, integration tests and continuous test suites. Details on these processes are provided in the report as a building step for a SHARP user guide that will accompany the first release, expected by Mar 2016.« less

The Behavioral Economics of Young Adult Substance Abuse

PubMed Central

Murphy, James G.; Dennhardt, Ashley A.

2016-01-01

Alcohol and drug use peaks during young adulthood and can interfere with critical developmental tasks and set the stage for chronic substance misuse and associated social, educational, and health-related outcomes. There is a need for novel, theory-based approaches to guide substance abuse prevention efforts during this critical developmental period. This paper discusses the particular relevance of behavioral economic theory to young adult alcohol and drug misuse, and reviews available literature on prevention and intervention strategies that are consistent with behavioral economic theory. Behavioral economic theory predicts that decisions to use drugs and alcohol are related to the relative availability and price of both alcohol and substance-free alternative activities, and the extent to which reinforcement from delayed substance-free outcomes is devalued relative to the immediate reinforcement associated with drugs. Behavioral economic measures of motivation for substance use are based on relative levels of behavioral and economic resource allocation towards drug versus alternatives, and have been shown to predict change in substance use over time. Policy and individual level prevention approaches that are consistent with behavioral economic theory are discussed, including brief interventions that increase future orientation and engagement in rewarding alternatives to substance use. Prevention approaches that increase engagement in constructive future-oriented activities among young adults (e.g., educational/vocational success) have the potential to reduce future health disparities associated with both substance abuse and poor educational/vocational outcomes. PMID:27151545

Overview of past, present and future marine power plants

NASA Astrophysics Data System (ADS)

Morsy El-Gohary, M.

2013-06-01

In efforts to overcome an foreseeable energy crisis predicated on limited oil and gas supplies, reserves; economic variations facing the world, and of course the environmental side effects of fossil fuels, an urgent need for energy sources that provide sustainable, safe and economic supplies for the world is imperative. The current fossil fuel energy system must be improved to ensure a better and cleaner transportation future for the world. Despite the fact that the marine transportation sector consumes only 5% of global petroleum production; it is responsible for 15% of the world NO x and SO x emissions. These figures must be the engine that powers the scientific research worldwide to develop new solutions for a very old energy problem. In this paper, the most effective types of marine power plants were discussed. The history of the development of each type was presented first and the technical aspects were discussed second. Also, the fuel cells as a new type of power plants used in marine sector were briefed to give a complete overview of the past, present and future of the marine power plants development. Based on the increased worldwide concerns regarding harmful emissions, many researchers have introduced solutions to this problem, including the adoption of new cleaner fuels. This paper was guided using the same trend and by implementing the hydrogen as fuel for marine internal combustion engine, gas turbines, and fuel cells.

[Marketing mix in a radiology department: challenges for future radiologists in management].

PubMed

Claikens, B

1998-08-01

Radiology has gained an enviable position among medial specialities. Developments in new technology expand its horizons and the volume of radiologic imaging techniques and procedures increase far more than the overall growth in health care services. In this position radiology has become a prime target for restrictions, cutbacks, controlled financing in an area of managed care and new national health care policy based on partially fixed budgets. Future health care takers have to choose the best available diagnostic and therapeutic techniques. Evidence based medicine, cost-utility analysis, diagnostic performance analysis, patient outcome analysis, technology assessment and guidelines for practice are means to guide us through our obligatory choice. Our major objective is to use the most performant available imaging technique or intervention to achieve the best possible outcome for our patient at lower possible costs. A strategic response from radiologists is required to meet the imperatives of this new management situation. They must do far more than interpret imaging procedures. They must work as efficient managers of imaging resources, organise their practices and define their marketing-strategies using the different, so-called, marketing-mix elements. The challenges will be great but the rewards are worth our best efforts. In this article we highlight the marketing responsibilities of future radiologists and their clinical practice in this new socio-economic environment and we present different useful marketing tools.

Emergency medical services : agenda for the future

DOT National Transportation Integrated Search

1996-08-01

The purpose of the EMS Agenda for the Future is to determine the most important directions for future EMS development, incorporating input from a broad, multidisciplinary spectrum of EMS stakeholders. This document provides guiding principles for the...