Achromatic Focal Plane Mask for Exoplanet Imaging Coronagraphy

NASA Technical Reports Server (NTRS)

Newman, Kevin Edward; Belikov, Ruslan; Guyon, Olivier; Balasubramanian, Kunjithapatham; Wilson, Dan

2013-01-01

Recent advances in coronagraph technologies for exoplanet imaging have achieved contrasts close to 1e10 at 4 lambda/D and 1e-9 at 2 lambda/D in monochromatic light. A remaining technological challenge is to achieve high contrast in broadband light; a challenge that is largely limited by chromaticity of the focal plane mask. The size of a star image scales linearly with wavelength. Focal plane masks are typically the same size at all wavelengths, and must be sized for the longest wavelength in the observational band to avoid starlight leakage. However, this oversized mask blocks useful discovery space from the shorter wavelengths. We present here the design, development, and testing of an achromatic focal plane mask based on the concept of optical filtering by a diffractive optical element (DOE). The mask consists of an array of DOE cells, the combination of which functions as a wavelength filter with any desired amplitude and phase transmission. The effective size of the mask scales nearly linearly with wavelength, and allows significant improvement in the inner working angle of the coronagraph at shorter wavelengths. The design is applicable to almost any coronagraph configuration, and enables operation in a wider band of wavelengths than would otherwise be possible. We include initial results from a laboratory demonstration of the mask with the Phase Induced Amplitude Apodization coronagraph.

High operating temperature interband cascade focal plane arrays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tian, Z.-B.; Godoy, S. E.; Kim, H. S.

2014-08-04

In this paper, we report the initial demonstration of mid-infrared interband cascade (IC) photodetector focal plane arrays with multiple-stage/junction design. The merits of IC photodetectors include low noise and efficient photocarrier extraction, even for zero-bias operation. By adopting enhanced electron barrier design and a total absorber thickness of 0.7 μm, the 5-stage IC detectors show very low dark current (1.10 × 10{sup −7} A/cm{sup 2} at −5 mV and 150 K). Even with un-optimized fabrication and standard commercial (mis-matched) read-out circuit technology, infrared images are obtained by the 320 × 256 IC focal plane array up to 180 K with f/2.3 optics. The minimum noise equivalent temperature differencemore » of 28 mK is obtained at 120 K. These initial results indicate great potential of IC photodetectors, particularly for high operating temperature applications.« less

Quantum-Well Infrared Photodetector (QWIP) Focal Plane Assembly

NASA Technical Reports Server (NTRS)

Jhabvala, Murzy; Jhabvala, Christine A.; Ewin, Audrey J.; Hess, Larry A.; Hartmann, Thomas M.; La, Anh T.

2012-01-01

A paper describes the Thermal Infrared Sensor (TIRS), a QWIP-based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM). The TIRS instrument is a far-infrared imager operating in the pushbroom mode with two IR channels: 10.8 and 12 microns. The focal plane will contain three 640x512 QWIP arrays mounted on a silicon substrate. The silicon substrate is a custom-fabricated carrier board with a single layer of aluminum interconnects. The general fabrication process starts with a 4-in. (approx.10-cm) diameter silicon wafer. The wafer is oxidized, a single substrate contact is etched, and aluminum is deposited, patterned, and alloyed. This technology development is aimed at incorporating three large-format infrared detecting arrays based on GaAs QWIP technology onto a common focal plane with precision alignment of all three arrays. This focal plane must survive the rigors of flight qualification and operate at a temperature of 43 K (-230 C) for five years while orbiting the Earth. The challenges presented include ensuring thermal compatibility among all the components, designing and building a compact, somewhat modular system and ensuring alignment to very tight levels. The multi-array focal plane integrated onto a single silicon substrate is a new application of both QWIP array development and silicon wafer scale integration. The Invar-based assembly has been tested to ensure thermal reliability.

Performance of an Achromatic Focal Plane Mask for Exoplanet Imaging Coronagraphy

NASA Technical Reports Server (NTRS)

Newman, Kevin; Belikov, Ruslan; Pluzhnik, Eugene; Balasubramanian, Kunjithapatham; Wilson, Dan

2014-01-01

Coronagraph technology combined with wavefront control is close to achieving the contrast and inner working angle requirements in the lab necessary to observe the faint signal of an Earth-like exoplanet in monochromatic light. An important remaining technological challenge is to achieve high contrast in broadband light. Coronagraph bandwidth is largely limited by chromaticity of the focal plane mask, which is responsible for blocking the stellar PSF. The size of a stellar PSF scales linearly with wavelength; ideally, the size of the focal plane mask would also scale with wavelength. A conventional hard-edge focal plane mask has a fixed size, normally sized for the longest wavelength in the observational band to avoid starlight leakage. The conventional mask is oversized for shorter wavelengths and blocks useful discovery space. Recently we presented a solution to the size chromaticity challenge with a focal plane mask designed to scale its effective size with wavelength. In this paper, we analyze performance of the achromatic size-scaling focal plane mask within a Phase Induced Amplitude Apodization (PIAA) coronagraph. We present results from wavefront control around the achromatic focal plane mask, and demonstrate the size-scaling effect of the mask with wavelength. The edge of the dark zone, and therefore the inner working angle of the coronagraph, scale with wavelength. The achromatic mask enables operation in a wider band of wavelengths compared with a conventional hard-edge occulter.

Out-of-focal plane imaging by leakage radiation microscopy

NASA Astrophysics Data System (ADS)

Zhu, Liangfu; Zhang, Douguo; Wang, Ruxue; Wen, Xiaolei; Wang, Pei; Ming, Hai; Badugu, Ramachandram; Lakowicz, Joseph R.

2017-09-01

Leakage radiation microscopy (LRM) is used to investigate the optical properties of surfaces. The front-focal plane (FFP) image with LRM reveals the structural features on the surfaces. A back-focal plane (BFP) image with LRM reveals the angular distribution of the radiation. Herein, we experimentally demonstrate that the out-of-focal plane (OFP) images present a link between the FFP and BFP images and provide optical information that cannot be resolved by either FFP or BFP images. The OFP image provides a link between the spatial location of the emission and the angular distribution from the same location, and thus information about the film’s discontinuity, nonuniformity or variable thickness can be uncovered. The use of OFP imaging will extend the scope and applications of the LRM and coupled emission imaging, which are powerful tools in nanophotonics and high throughput fluorescence screening.

System and method for generating a deselect mapping for a focal plane array

DOEpatents

Bixler, Jay V; Brandt, Timothy G; Conger, James L; Lawson, Janice K

2013-05-21

A method for generating a deselect mapping for a focal plane array according to one embodiment includes gathering a data set for a focal plane array when exposed to light or radiation from a first known target; analyzing the data set for determining which pixels or subpixels of the focal plane array to add to a deselect mapping; adding the pixels or subpixels to the deselect mapping based on the analysis; and storing the deselect mapping. A method for gathering data using a focal plane array according to another embodiment includes deselecting pixels or subpixels based on a deselect mapping; gathering a data set using pixels or subpixels in a focal plane array that are not deselected upon exposure thereof to light or radiation from a target of interest; and outputting the data set.

Starbugs: focal plane fiber positioning technology

NASA Astrophysics Data System (ADS)

Goodwin, Michael; Heijmans, Jeroen; Saunders, Ian; Brzeski, Jurek; Saunders, Will; Muller, Rolf; Haynes, Roger; Gilbert, James

2010-07-01

We report on the technological achievements of our latest Starbug prototypes and their implications for smart focal plane fiber positioning applications for wide-field astronomy. The Starbugs are innovative self-motile miniature robotic devices that can simultaneously and independently position fibers or payloads over a field plate located at the telescope's focal plane. The Starbugs concept overcomes many of the limitations associated with the traditional 'pick and place' positioners where a robot places fixed buttons onto the field plate. The new Starbug prototypes use piezoelectric actuators and have the following features: (i) new 'lift-and-step' method (discrete step) for accurate positioning over different surfaces; and (ii) operate in an inverted hanging position underneath a transparent field plate, removing the need for fibercable retractors. In this paper, we present aspects of the Starbug prototypes, including the theoretical model, mechanical design, experimental setup, algorithms, performance and applications for astronomical instrumentation.

Verification of the SENTINEL-4 Focal Plane Subsystem

NASA Astrophysics Data System (ADS)

Williges, C.; Hohn, R.; Rossmann, H.; Hilbert, S.; Uhlig, M.; Buchwinkler, K.; Reulke, R.

2017-05-01

The Sentinel-4 payload is a multi-spectral camera system which is designed to monitor atmospheric conditions over Europe. The German Aerospace Center (DLR) in Berlin, Germany conducted the verification campaign of the Focal Plane Subsystem (FPS) on behalf of Airbus Defense and Space GmbH, Ottobrunn, Germany. The FPS consists, inter alia, of two Focal Plane Assemblies (FPAs), one for the UV-VIS spectral range (305 nm … 500 nm), the second for NIR (750 nm … 775 nm). In this publication, we will present in detail the opto-mechanical laboratory set-up of the verification campaign of the Sentinel-4 Qualification Model (QM) which will also be used for the upcoming Flight Model (FM) verification. The test campaign consists mainly of radiometric tests performed with an integrating sphere as homogenous light source. The FPAs have mainly to be operated at 215 K ± 5 K, making it necessary to exploit a thermal vacuum chamber (TVC) for the test accomplishment. This publication focuses on the challenge to remotely illuminate both Sentinel-4 detectors as well as a reference detector homogeneously over a distance of approximately 1 m from outside the TVC. Furthermore selected test analyses and results will be presented, showing that the Sentinel-4 FPS meets specifications.

Focal plane for the next generation of earth observation instruments

NASA Astrophysics Data System (ADS)

Pranyies, P.; Toubhans, I.; Badoil, B.; Tanguy, F.; Descours, Francis

2017-09-01

Sodern is the French focal plane provider for Earth Observation (EO) satellites. Since the 1980's, Sodern has played an active role first in the SPOT program. Within the two-spacecraft constellation Pleiades 1A/1B over the next years, Sodern introduced advanced technologies as Silicon Carbide (SiC) focal plane structure and multispectral strip filters dedicated to multiple-lines detectors.

The Sentinel 4 focal plane subsystem

NASA Astrophysics Data System (ADS)

Hohn, Rüdiger; Skegg, Michael P.; Hermsen, Markus; Hinger, Jürgen; Williges, Christian; Reulke, Ralf

2017-09-01

The Sentinel 4 instrument is an imaging spectrometer, developed by Airbus under ESA contract in the frame of the joint European Union (EU)/ESA COPERNICUS program with the objective of monitoring trace gas concentrations. Sentinel 4 will provide accurate measurements of key atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, formaldehyde, as well as aerosol and cloud properties. Sentinel 4 is unique in being the first geostationary UVN mission. The SENTINEL 4 space segment will be integrated on EUMETSAT's Meteosat Third Generation Sounder satellite (MTG-S). Sentinel 4 will provide coverage of Europe and adjacent regions. The Sentinel 4 instrument comprises as a major element two Focal Plane Subsystems (FPS) covering the wavelength ranges 305 nm to 500 nm (UVVIS) and 750 nm to 775 nm (NIR) respectively. The paper describes the Focal Plane Subsystems, comprising the detectors, the optical bench and the control electronics. Further the design and development approach will be presented as well as first measurement results of FPS Qualification Model.

The Sentinel-4 UVN focal plane assemblies

NASA Astrophysics Data System (ADS)

Hinger, Jürgen; Hohn, Rüdiger; Gebhardt, Eyk; Reichardt, Jörg

2017-09-01

The Sentinel-4 UVN Instrument is a dispersive imaging spectrometer covering the UV-VIS and the NIR wavelength. It is developed and built under an ESA contract by an industrial consortium led by Airbus Defence and Space. It will be accommodated on board of the MTG-S (Meteosat Third Generation - Sounder) satellite that will be placed in a geostationary orbit over Europe sampling data for generating two-dimensional maps of a number of atmospheric trace gases. The incoming light is dispersed by reflective gratings and detected by the two (UVVIS and NIR) CCDs mounted inside the focal plane assemblies. Both CCD detectors acquire spectral channels and spatial sampling in two orthogonal directions and will be operated at about 215 K mainly to minimize random telegraph signal effects and to reduce dark current. Stringent detector temperature as well as alignment stability requirements of less than +/-0.1 K per day respectively of less than 2 micrometers/2 arcseconds from ground to orbit are driving the FPA thermo-mechanical design. A specific FPA design feature is the redundant LED-calibration system for bad pixel detection as well as pixel gain and linearity monitoring. This paper reports on the design and qualification of the Focal Plane Assemblies with emphasis on thermo-mechanical as well as alignment stability verification.

Kalman Filter for Calibrating a Telescope Focal Plane

NASA Technical Reports Server (NTRS)

Kang, Bryan; Bayard, David

2006-01-01

The instrument-pointing frame (IPF) Kalman filter, and an algorithm that implements this filter, have been devised for calibrating the focal plane of a telescope. As used here, calibration signifies, more specifically, a combination of measurements and calculations directed toward ensuring accuracy in aiming the telescope and determining the locations of objects imaged in various arrays of photodetectors in instruments located on the focal plane. The IPF Kalman filter was originally intended for application to a spaceborne infrared astronomical telescope, but can also be applied to other spaceborne and ground-based telescopes. In the traditional approach to calibration of a telescope, (1) one team of experts concentrates on estimating parameters (e.g., pointing alignments and gyroscope drifts) that are classified as being of primarily an engineering nature, (2) another team of experts concentrates on estimating calibration parameters (e.g., plate scales and optical distortions) that are classified as being primarily of a scientific nature, and (3) the two teams repeatedly exchange data in an iterative process in which each team refines its estimates with the help of the data provided by the other team. This iterative process is inefficient and uneconomical because it is time-consuming and entails the maintenance of two survey teams and the development of computer programs specific to the requirements of each team. Moreover, theoretical analysis reveals that the engineering/ science iterative approach is not optimal in that it does not yield the best estimates of focal-plane parameters and, depending on the application, may not even enable convergence toward a set of estimates.

Low power, highly linear output buffer. [for infrared focal plane arrays

NASA Technical Reports Server (NTRS)

Foley, D.; Butler, N.; Stobie, J.

1992-01-01

A class AB CMOS output buffer has been designed for use on an IR focal plane array. Given the requirements for power dissipation and load capacitance a class A output, such as a source follower, would be unsuitable. The approach taken uses a class AB amplifier configured as a charge integrator. Thus it converts a charge packet in the focal plane multiplexer to a voltage which is then the output of the focal plane. With a quiescent current of 18 micro-a and a load capacitance of 100 pf, the amplifier has an open loop unity gain bandwidth of 900 khz. Integral nonlinearity is better than .03 percent over 5.5 volts when run with VDD-VSS = 6v.

WFIRST: Principal Components Analysis of H4RG-10 Near-IR Detector Data Cubes

NASA Astrophysics Data System (ADS)

Rauscher, Bernard

2018-01-01

The Wide Field Infrared Survey Telescope’s (WFIRST) Wide Field Instrument (WFI) incorporates an array of eighteen Teledyne H4RG-10 near-IR detector arrays. Because WFIRST’s science investigations require controlling systematic uncertainties to state-of-the-art levels, we conducted principal components analysis (PCA) of some H4RG-10 test data obtained in the NASA Goddard Space Flight Center Detector Characterization Laboratory (DCL). The PCA indicates that the Legendre polynomials provide a nearly orthogonal representation of up-the-ramp sampled illuminated data cubes, and suggests other representations that may provide an even more compact representation of the data in some circumstances. We hypothesize that by using orthogonal representations, such as those described here, it may be possible to control systematic errors better than has been achieved before for NASA missions. We believe that these findings are probably applicable to other H4RG, H2RG, and H1RG based systems.

Infrared Spectroscopy of C_6D_6-Rg_n(n=1,2)

NASA Astrophysics Data System (ADS)

George, Jobin; Yousefi, Mahdi; Rezaei, Mojtaba; McKellar, Bob; Moazzen-Ahmadi, Nasser

2014-06-01

Benzene-noble gas complexes were one of the earliest topics of interest in spectroscopic investigation of van der Waals (vdW) complexes. Smalley et al. observed C_6H_6-(He)1,2 vdW complexes in the late 1970s by means of electronic spectroscopy. A recent study on the same species was done by M. Hayashi et al. Here, we present the infrared observation of C_6D_6-Rg_n (n=1,2) with the rare gas being He, Ne, or Ar, in the regions of νb{12} fundamental band of C_6D_6 (˜2289 wn) and the νb{2} + νb{13} combination band (˜2275 wn) which are coupled by a Fermi resonance. The spectra were observed at a resolution of 60 MHz using a tunable optical parametric oscillator to probe a pulsed supersonic-jet expansion from a slit nozzle. In the case of C_6D_6-Rg dimers, the spectra were assigned to a symmetric top with C6v symmetry with the rare gas atom being located on the C6 symmetry axis. To observe C_6D_6-Rg_2 trimers, the nozzle was cooled using a closed-cycle methanol refrigerator and the spectra were simulated with a rotational temperature of 1.3K. The spectra of the C_6D_6-Rg_2 trimers were in agreement with a D6h symmetry structure, where the rare gas atoms are positioned above and below the C_6D_6 plane. Data analysis and observation are presently ongoing. S. M. Beck, M. G. Liverman, D. L. Monts and R. E. Smalley, J. Chem. Phys. 70, 232 (1979). M. Hayashi, Y. Ohshima, Chem. Phys. 419, 131 (2013).

Development of a 2K x 2K GaAs QWIP Focal Plane Array

NASA Technical Reports Server (NTRS)

Jhabvala, M.; Choi, K.; Jhabvala, C.; Kelly, D.; Hess, L.; Ewin, A.; La, A.; Wacynski, A.; Sun, J.; Adachi, T.;

Large format focal plane array integration with precision alignment, metrology and accuracy capabilities

NASA Astrophysics Data System (ADS)

Neumann, Jay; Parlato, Russell; Tracy, Gregory; Randolph, Max

2015-09-01

Focal plane alignment for large format arrays and faster optical systems require enhanced precision methodology and stability over temperature. The increase in focal plane array size continues to drive the alignment capability. Depending on the optical system, the focal plane flatness of less than 25μm (.001") is required over transition temperatures from ambient to cooled operating temperatures. The focal plane flatness requirement must also be maintained in airborne or launch vibration environments. This paper addresses the challenge of the detector integration into the focal plane module and housing assemblies, the methodology to reduce error terms during integration and the evaluation of thermal effects. The driving factors influencing the alignment accuracy include: datum transfers, material effects over temperature, alignment stability over test, adjustment precision and traceability to NIST standard. The FPA module design and alignment methodology reduces the error terms by minimizing the measurement transfers to the housing. In the design, the proper material selection requires matched coefficient of expansion materials minimizes both the physical shift over temperature as well as lowering the stress induced into the detector. When required, the co-registration of focal planes and filters can achieve submicron relative positioning by applying precision equipment, interferometry and piezoelectric positioning stages. All measurements and characterizations maintain traceability to NIST standards. The metrology characterizes the equipment's accuracy, repeatability and precision of the measurements.

Space telescope optical telescope assembly/scientific instruments. Phase B: Preliminary design and program definition study. Volume 2A. focal plane camera

NASA Technical Reports Server (NTRS)

1976-01-01

Trade studies were conducted to ensure the overall feasibility of the focal plane camera in a radial module. The primary variable in the trade studies was the location of the pickoff mirror, on axis versus off-axis. Two alternatives were: (1) the standard (electromagnetic focus) SECO submodule, and (2) the MOD 15 permanent magnet focus SECO submodule. The technical areas of concern were the packaging affected parameters of thermal dissipation, focal plane obscuration, and image quality.

Fabrication of Transition Edge Sensor Microcalorimeters for X-Ray Focal Planes

NASA Technical Reports Server (NTRS)

Chervenak, James A.; Adams, Joseph S.; Audley, Heather; Bandler, Simon R.; Betancourt-Martinez, Gabriele; Eckart, Megan E.; Finkbeiner, Fred M.; Kelley, Richard L.; Kilbourne, Caroline; Lee, Sang Jun;

Dual band QWIP focal plane array

NASA Technical Reports Server (NTRS)

Gunapala, Sarath D. (Inventor); Choi, Kwong Kit (Inventor); Bandara, Sumith V. (Inventor)

2005-01-01

A quantum well infrared photodetector (QWIP) that provides two-color image sensing. Two different quantum wells are configured to absorb two different wavelengths. The QWIPs are arrayed in a focal plane array (FPA). The two-color QWIPs are selected for readout by selective electrical contact with the two different QWIPs or by the use of two different wavelength sensitive gratings.

Innovative compact focal plane array for wide field vis and ir orbiting telescopes

NASA Astrophysics Data System (ADS)

Hugot, Emmanuel; Vives, Sébastien; Ferrari, Marc; Gaeremynck, Yann; Jahn, Wilfried

2017-11-01

The future generation of high angular resolution space telescopes will require breakthrough technologies to combine large diameters and large focal plane arrays with compactness and lightweight mirrors and structures. Considering the allocated volume medium-size launchers, short focal lengths are mandatory, implying complex optical relays to obtain diffraction limited images on large focal planes. In this paper we present preliminary studies to obtain compact focal plane arrays (FPA) for earth observations on low earth orbits at high angular resolution. Based on the principle of image slicers, we present an optical concept to arrange a 1D FPA into a 2D FPA, allowing the use of 2D detector matrices. This solution is particularly attractive for IR imaging requiring a cryostat, which volume could be considerably reduced as well as the relay optics complexity. Enabling the use of 2D matrices for such an application offers new possibilities. Recent developments on curved FPA allows optimization without concerns on the field curvature. This innovative approach also reduces the complexity of the telescope optical combination, specifically for fast telescopes. This paper will describe the concept and optical design of an F/5 - 1.5m telescope equipped with such a FPA, the performances and the impact on the system with a comparison with an equivalent 1.5m wide field Korsch telescope.

Radiometric infrared focal plane array imaging system for thermographic applications

NASA Technical Reports Server (NTRS)

Esposito, B. J.; Mccafferty, N.; Brown, R.; Tower, J. R.; Kosonocky, W. F.

1992-01-01

This document describes research performed under the Radiometric Infrared Focal Plane Array Imaging System for Thermographic Applications contract. This research investigated the feasibility of using platinum silicide (PtSi) Schottky-barrier infrared focal plane arrays (IR FPAs) for NASA Langley's specific radiometric thermal imaging requirements. The initial goal of this design was to develop a high spatial resolution radiometer with an NETD of 1 percent of the temperature reading over the range of 0 to 250 C. The proposed camera design developed during this study and described in this report provides: (1) high spatial resolution (full-TV resolution); (2) high thermal dynamic range (0 to 250 C); (3) the ability to image rapid, large thermal transients utilizing electronic exposure control (commandable dynamic range of 2,500,000:1 with exposure control latency of 33 ms); (4) high uniformity (0.5 percent nonuniformity after correction); and (5) high thermal resolution (0.1 C at 25 C background and 0.5 C at 250 C background).

Radiometric infrared focal plane array imaging system for thermographic applications

NASA Astrophysics Data System (ADS)

Esposito, B. J.; McCafferty, N.; Brown, R.; Tower, J. R.; Kosonocky, W. F.

1992-11-01

This document describes research performed under the Radiometric Infrared Focal Plane Array Imaging System for Thermographic Applications contract. This research investigated the feasibility of using platinum silicide (PtSi) Schottky-barrier infrared focal plane arrays (IR FPAs) for NASA Langley's specific radiometric thermal imaging requirements. The initial goal of this design was to develop a high spatial resolution radiometer with an NETD of 1 percent of the temperature reading over the range of 0 to 250 C. The proposed camera design developed during this study and described in this report provides: (1) high spatial resolution (full-TV resolution); (2) high thermal dynamic range (0 to 250 C); (3) the ability to image rapid, large thermal transients utilizing electronic exposure control (commandable dynamic range of 2,500,000:1 with exposure control latency of 33 ms); (4) high uniformity (0.5 percent nonuniformity after correction); and (5) high thermal resolution (0.1 C at 25 C background and 0.5 C at 250 C background).

MIXS on BepiColombo and its DEPFET based focal plane instrumentation

NASA Astrophysics Data System (ADS)

Treis, J.; Andricek, L.; Aschauer, F.; Heinzinger, K.; Herrmann, S.; Hilchenbach, M.; Lauf, T.; Lechner, P.; Lutz, G.; Majewski, P.; Porro, M.; Richter, R. H.; Schaller, G.; Schnecke, M.; Schopper, F.; Soltau, H.; Stefanescu, A.; Strüder, L.; de Vita, G.

2010-12-01

Focal plane instrumentation based on DEPFET Macropixel devices, being a combination of the Detector-Amplifier structure DEPFET with a silicon drift chamber (SDD), has been proposed for the MIXS (Mercury Imaging X-ray Spectrometer) instrument on ESA's Mercury exploration mission BepiColombo. MIXS images X-ray fluorescent radiation from the Mercury surface with a lightweight X-ray mirror system on the focal plane detector to measure the spatially resolved element abundance in Mercury's crust. The sensor needs to have an energy resolution better than 200 eV FWHM at 1 keV and is required to cover an energy range from 0.5 to 10 keV, for a pixel size of 300×300μm2. Main challenges for the instrument are radiation damage and the difficult thermal environment in the mercury orbit. The production of the first batch of flight devices has been finished at the MPI semiconductor laboratory. Prototype modules have been assembled to verify the electrical properties of the devices; selected results are presented here. The prototype devices, Macropixel prototypes for the SIMBOL-X focal plane, are electrically fully compatible, but have a pixel size of 0.5×0.5 mm2. Excellent homogeneity and near Fano-limited energy resolution at high readout speeds have been observed on these devices.

The Simbol-X Focal Plane

NASA Astrophysics Data System (ADS)

Laurent, P.

2009-05-01

The Simbol-X focal plane is designed to detect photons focused by the mirror in the 0.5 to 100 keV energy band. Composed of two detectors, it will measure the position, energy, and arrival time of each incoming X-ray. On top of it will be a collimator to shield all photons not coming from the mirror field of view. The whole system is surrounded by an active and passive shielding in order to ensure the required very low background.

Optimal focal-plane restoration

NASA Technical Reports Server (NTRS)

Reichenbach, Stephen E.; Park, Stephen K.

1989-01-01

Image restoration can be implemented efficiently by calculating the convolution of the digital image and a small kernel during image acquisition. Processing the image in the focal-plane in this way requires less computation than traditional Fourier-transform-based techniques such as the Wiener filter and constrained least-squares filter. Here, the values of the convolution kernel that yield the restoration with minimum expected mean-square error are determined using a frequency analysis of the end-to-end imaging system. This development accounts for constraints on the size and shape of the spatial kernel and all the components of the imaging system. Simulation results indicate the technique is effective and efficient.

Materials, devices, techniques, and applications for Z-plane focal plane array technology II; Proceedings of the Meeting, San Diego, CA, July 12, 13, 1990

NASA Astrophysics Data System (ADS)

Carson, John C.

1990-11-01

Various papers on materials, devices, techniques, and applications for X-plane focal plane array technology are presented. Individual topics addressed include: application of Z-plane technology to the remote sensing of the earth from GEO, applications of smart neuromorphic focal planes, image-processing of Z-plane technology, neural network Z-plane implementation with very high interconnection rates, using a small IR surveillance satellite for tactical applications, establishing requirements for homing applications, Z-plane technology. Also discussed are: on-array spike suppression signal processing, algorithms for on-focal-plane gamma circumvention and time-delay integration, current HYMOSS Z-technology, packaging of electrons for on- and off-FPA signal processing, space/performance qualification of tape automated bonded devices, automation in tape automated bonding, high-speed/high-volume radiometric testing of Z-technology focal planes, 128-layer HYMOSS-module fabrication issues, automation of IRFPA production processes.

H2RG Detector Characterization for RIMAS and Instrument Efficiencies

NASA Technical Reports Server (NTRS)

Toy, Vicki L.; Kutyrev, Alexander S.; Capone, John I.; Hams, Thomas; Robinson, F. David; Lotkin, Gennadiy N.; Veilleux, Sylvain; Moseley, Samuel H.; Gehrels, Neil A.; Vogel, Stuart N.

2016-01-01

The Rapid infrared IMAger-Spectrometer (RIMAS) is a near-infrared (NIR) imager and spectrometer that will quickly follow up gamma-ray burst afterglows on the 4.3-meter Discovery Channel Telescope (DCT). RIMAS has two optical arms which allows simultaneous coverage over two bandpasses (YJ and HK) in either imaging or spectroscopy mode. RIMAS utilizes two Teledyne HgCdTe H2RG detectors controlled by Astronomical Research Cameras, Inc. (ARC/Leach) drivers. We report the laboratory characterization of RIMAS's detectors: conversion gain, read noise, linearity, saturation, dynamic range, and dark current. We also present RIMAS's instrument efficiency from atmospheric transmission models and optics data (both telescope and instrument) in all three observing modes.

Next generation sub-millimeter wave focal plane array coupling concepts: an ESA TRP project to develop multichroic focal plane pixels for future CMB polarization experiments

NASA Astrophysics Data System (ADS)

Trappe, N.; Bucher, M.; De Bernardis, P.; Delabrouille, J.; Deo, P.; DePetris, M.; Doherty, S.; Ghribi, A.; Gradziel, M.; Kuzmin, L.; Maffei, B.; Mahashabde, S.; Masi, S.; Murphy, J. A.; Noviello, F.; O'Sullivan, C.; Pagano, L.; Piacentini, F.; Piat, M.; Pisano, G.; Robinson, M.; Stompor, R.; Tartari, A.; van der Vorst, M.; Verhoeve, P.

2016-07-01

The main objective of this activity is to develop new focal plane coupling array concepts and technologies that optimise the coupling from reflector optics to the large number of detectors for next generation sub millimetre wave telescopes particularly targeting measurement of the polarization of the cosmic microwave background (CMB). In this 18 month TRP programme the consortium are tasked with developing, manufacturing and experimentally verifying a prototype multichroic pixel which would be suitable for the large focal plane arrays which will be demanded to reach the required sensitivity of future CMB polarization missions. One major development was to have multichroic operation to potentially reduce the required focal plane size of a CMB mission. After research in the optimum telescope design and definition of requirements based on a stringent science case review, a number of compact focal plane architecture concepts were investigated before a pixel demonstrator consisting of a planar mesh lens feeding a backend Resonant Cold Electron Bolometer RCEB for filtering and detection of the dual frequency signal was planned for manufacture and test. In this demonstrator the frequencies of the channels was chosen to be 75 and 105 GHz in the w band close to the peak CMB signal. In the next year the prototype breadboards will be developed to test the beams produced by the manufactured flat lenses fed by a variety of antenna configurations and the spectral response of the RCEBs will also be verified.

Focal plane AIT sequence: evolution from HRG-Spot 5 to Pleiades HR

NASA Astrophysics Data System (ADS)

Le Goff, Roland; Pranyies, Pascal; Toubhans, Isabelle

2017-11-01

Optical and geometrical image qualities of Focal Planes, for "push-broom" high resolution remote sensing satellites, require the implementation of specific means and methods for the AIT sequence. Indeed the geometric performances of the focal plane mainly axial focusing and transverse registration, are duly obtained on the basis of adjustment, setting and measurement of optical and CCD components with an accuracy of a few microns. Since the end of the 1970s, EADS-SODERN has developed a series of detection units for earth observation instruments like SPOT and Helios. And EADS-SODERN is now responsible for the development of the Pleiades High Resolution Focal Plane assembly. This paper presents the AIT sequences. We introduce all the efforts, innovative solutions and improvements made on the assembly facilities to match the technical evolutions and breakthrough of the Pleiades HR FP concept in comparison with the previous High Resolution Geometric SPOT 5 Focal Plane. The main evolution drivers are the implementation of strip filters and the realization of 400 mm continuous retinas. For Pleiades HR AIT sequence, three specific integration and measuring benches, corresponding with the different assembly stages, are used: a 3-D non-contact measurement machine for the assembly of detection module, a 3-D measurement machine for mirror integration on the main Focal Plane SiC structure, and a 3-D geometric coordinates control bench to focus detection module lines and to ensure they are well registered together.

Study on observation planning of LAMOST focal plane positioning system and its simulation

NASA Astrophysics Data System (ADS)

Zhai, Chao; Jin, Yi; Peng, Xiaobo; Xing, Xiaozheng

2006-06-01

Fiber Positioning System of LAMOST focal plane based on subarea thinking, adopts a parallel controllable positioning plan, the structure is designed as a round area and overlapped each other in order to eliminate the un-observation region. But it also makes the observation efficiency of the system become an important problem. In this paper According to the system, the model of LAMOST focal plane Observation Planning including 4000 fiber positioning units is built, Stars are allocated using netflow algorithm and mechanical collisions are diminished through the retreat algorithm, then the simulation of the system's observation efficiency is carried out. The problem of observation efficiency of LAMOST focal plane is analysed systemic and all-sided from the aspect of overlapped region, fiber positioning units, observation radius, collisions and so on. The observation efficiency of the system in theory is describes and the simulation indicates that the system's observation efficiency is acceptable. The analyses play an indicative role on the design of the LAMOST focal plane structure.

Building an Experimental Setup to Characterize an H4RG-15

NASA Astrophysics Data System (ADS)

Hirata, Mickie; Hodapp, K.; Hall, Donald N. B.; Goebel, Sean B.; Jacobson, Shane M.

2018-01-01

The Teledyne Imaging Sensors H4RG-15 infrared detector is designed for the next era of extremely large telescopes. Characterization of individual H4RG-15 detectors are critical for future astronomical use. ULBcam, a former UH88 IR camera and remnant test dewar for H2RG characterization, was previously modified for H4RG-15 characterization. During the summer, this system was further upgraded with a baffle tube to a blackbody illumination source to allow controlled field illumination. This baffle tube, designed in OpenSCAD, was constructed in the IfA machine shop. Specific placements of the 50-micron aperture and scatter restrictive baffling was designed in Zemax. Four separate data sets were acquired to look into detector persistence, dark current, read noise, and charge gain. With the illumination source set at 450 K, ten ramps of 90/90 read frames were taken to pass saturation values. These tests were repeated at 500K to show results at over saturated conditions. Five ramps of 136/136 read frames were taken with a blank shutter applied. The persistence results showed expected results with signals settling from the third ramp. Dark current results showed higher than Teledyne stated values at 0.06 electrons/second, a factor of 6 higher than expected, which exposes systematic ULBcam dark testing capabilities. The read noise resulted with an expected value of 0.014 electrons. The charge gain showed 0.02 electrons/ADU where the expected value is 2 electrons/ADU. Data analysis using reference frame subtraction will be done for future work.

Radiation-Induced Transient Effects in Near Infrared Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Reed, Robert A.; Pickel, J.; Marshall, P.; Waczynski, A.; McMurray, R.; Gee, G.; Polidan, E.; Johnson, S.; McKeivey, M.; Ennico, K.;

Predicted NMR properties of noble gas hydride cations RgH +

NASA Astrophysics Data System (ADS)

Cukras, Janusz; Sadlej, Joanna

2008-12-01

The NMR shielding constants and, for the first time, the spin-spin coupling constants of Rg and H in RgH + compounds for Rg = Ne, Ar, Kr, Xe have been investigated by non-relativistic Hartree-Fock (HF) and relativistic Dirac-Hartree-Fock (DHF) methods. Electron-correlation effects have been furthermore calculated using SOPPA and CCSD at the non-relativistic level. The correlation effects are large on both parameters and opposite to the relativistic effects. The results indicate that both the relativistic and correlation effects need to be taken into account in a quantitative computations, especially in the case of the spin-spin coupling constants.

Short wavelength HgCdTe staring focal plane for low background astronomy applications

NASA Technical Reports Server (NTRS)

Hall, D.; Stobie, J.; Hartle, N.; Lacroix, D.; Maschhoff, K.

1989-01-01

The design of a 128x128 staring short wave infrared (SWIR) HgCdTe focal plane incorporating charge integrating transimpedance input preamplifiers is presented. The preamplifiers improve device linearity and uniformity, and provide signal gain ahead of the miltiplexer and readout circuitry. Detector's with cutoff wavelength of 2.5 microns and operated at 80 K have demonstrated impedances in excess of 10(exp 16) ohms with 60 percent quantum efficiency. Focal plane performance using a smaller format device is presented which demonstrates the potential of this approach. Although the design is capable of achieving less than 30 rms electrons with todays technology, initial small format devices demonstrated a read noise of 100 rms electrons and were limited by the atypical high noise performance of the silicon process run. Luminescence from the active silicon circuitry in the multiplexer limits the minimum detector current to a few hundred electrons per second. Approaches to eliminate this excessive source of current is presented which should allow the focal plane to achieve detector background limited performance.

Uncooled infrared focal plane array imaging in China

NASA Astrophysics Data System (ADS)

Lei, Shuyu

2015-06-01

This article reviews the development of uncooled infrared focal plane array (UIFPA) imaging in China in the past decade. Sensors based on optical or electrical read-out mechanism were developed but the latter dominates the market. In resistive bolometers, VOx and amorphous silicon are still the two major thermal-sensing materials. The specifications of the IRFPA made by different manufactures were collected and compared. Currently more than five Chinese companies and institutions design and fabricate uncooled infrared focal plane array. Some devices have sensitivity as high as 30 mK; the largest array for commercial products is 640×512 and the smallest pixel size is 17 μm. Emphasis is given on the pixel MEMS design, ROIC design, fabrication, and packaging of the IRFPA manufactured by GWIC, especially on design for high sensitivities, low noise, better uniformity and linearity, better stabilization for whole working temperature range, full-digital design, etc.

Performance of the QWIP Focal Plane Arrays for NASA's Landsat Data Continuity Mission

NASA Technical Reports Server (NTRS)

Jhabvala, M.; Choi, K.; Waczynski, A.; La, A.; Sundaram, M.; Costard, E.; Jhabvala, C.; Kan, E.; Kahle, D.; Foltz, R.;

Development and Testing of an Innovative Two-Arm Focal-Plane Thermal Strap (TAFTS)

NASA Technical Reports Server (NTRS)

Urquiza, E.; Vasquez, C.; Rodriguez, J.; Van Gorp, B.

2011-01-01

Maintaining temperature stability in optical focal planes comes with the intrinsic challenge of creating a pathway that is both extremely flexible mechanically and highly conductive thermally. The task is further complicated because science-caliber optical focal planes are extremely delicate, yet their mechanical resiliency is rarely tested and documented. The mechanical engineer tasked with the thermo-mechanical design must then create a highly conductive thermal link that minimizes the tensile and shear stresses transmitted to the focal plane without design parameters on an acceptable stiffness. This paper will describe the development and testing of the thermal link developed for the Portable Remote Imaging Spectrometer (PRISM) instrument. It will provide experimentally determined mechanical stiffness plots in the three axes of interest. Analytical and experimental thermal conductance results for the two-arm focal-plane thermal strap (TAFTS), from cryogenic to room temperatures, are also presented. The paper also briefly describes some elements of the fabrication process followed in developing a novel design solution, which provides high conductance and symmetrical mechanical loading, while providing enhanced flexibility in all three degrees of freedom.

Optimizing focal plane electric field estimation for detecting exoplanets

NASA Astrophysics Data System (ADS)

Groff, T.; Kasdin, N. J.; Riggs, A. J. E.

Detecting extrasolar planets with angular separations and contrast levels similar to Earth requires a large space-based observatory and advanced starlight suppression techniques. This paper focuses on techniques employing an internal coronagraph, which is highly sensitive to optical errors and must rely on focal plane wavefront control techniques to achieve the necessary contrast levels. To maximize the available science time for a coronagraphic mission we demonstrate an estimation scheme using a discrete time Kalman filter. The state estimate feedback inherent to the filter allows us to minimize the number of exposures required to estimate the electric field. We also show progress including a bias estimate into the Kalman filter to eliminate incoherent light from the estimate. Since the exoplanets themselves are incoherent to the star, this has the added benefit of using the control history to gain certainty in the location of exoplanet candidates as the signal-to-noise between the planets and speckles improves. Having established a purely focal plane based wavefront estimation technique, we discuss a sensor fusion concept where alternate wavefront sensors feedforward a time update to the focal plane estimate to improve robustness to time varying speckle. The overall goal of this work is to reduce the time required for wavefront control on a target, thereby improving the observatory's planet detection performance by increasing the number of targets reachable during the lifespan of the mission.

Large-format InGaAs focal plane arrays for SWIR imaging

NASA Astrophysics Data System (ADS)

Hood, Andrew D.; MacDougal, Michael H.; Manzo, Juan; Follman, David; Geske, Jonathan C.

2012-06-01

FLIR Electro Optical Components will present our latest developments in large InGaAs focal plane arrays, which are used for low light level imaging in the short wavelength infrared (SWIR) regime. FLIR will present imaging from their latest small pitch (15 μm) focal plane arrays in VGA and High Definition (HD) formats. FLIR will present characterization of the FPA including dark current measurements as well as the use of correlated double sampling to reduce read noise. FLIR will show imagery as well as FPA-level characterization data.

Extending Hyperspectral Capabilities with Dualband Infrared Focal Plane Arrays

DTIC Science & Technology

2007-01-01

plane array. The next challenge to implementing a dualband IR CTIS system is overcoming the signal to noise ratio. The signal through the CTIS...communication), enabling the 720x720 CTIS goals described above. More recently, a 1024x1024, dualband quantum well infrared photodetector ( QWIP ...62950D (2006). 9. S. D. Gunapala, et al., “Towards Dualband Megapixel QWIP Focal Plane Arrays”, Proceedings of International Workshop on Quantum Well

Automatic test comes to focal plane array production

NASA Astrophysics Data System (ADS)

Skaggs, Frank L.; Barton, T. D.

1992-08-01

To meet the needs of military and commercial markets, the infrared focal plane array industry must develop new, effective and low cost methods of fabricating and testing imaging detectors. This paper describes Texas Instruments new concepts in automated testing and cold probe technology as they apply to volume production.

High Frequency High Spectral Resolution Focal Plane Arrays for AtLAST

NASA Astrophysics Data System (ADS)

Baryshev, Andrey

2018-01-01

Large collecting area single dish telescope such as ATLAST will be especially effective for medium (R 1000) and high (R 50000) spectral resolution observations. Large focal plane array is a natural solution to increase mapping speed. For medium resolution direct detectors with filter banks (KIDs) and or heterodyne technology can be employed. We will analyze performance limits of comparable KID and SIS focal plane array taking into account quantum limit and high background condition of terrestrial observing site. For large heterodyne focal plane arrays, a high current density AlN junctions open possibility of large instantaneous bandwidth >40%. This and possible multi frequency band FPSs presents a practical challenge for spatial sampling and scanning strategies. We will discuss phase array feeds as a possible solution, including a modular back-end system, which can be shared between KID and SIS based FPA. Finally we will discuss achievable sensitivities and pixel co unts for a high frequency (>500 GHz) FPAs and address main technical challenges: LO distribution, wire counts, bias line multiplexing, and monolithic vs. discrete mixer component integration.

An Integrated Optimal Estimation Approach to Spitzer Space Telescope Focal Plane Survey

NASA Technical Reports Server (NTRS)

Bayard, David S.; Kang, Bryan H.; Brugarolas, Paul B.; Boussalis, D.

2004-01-01

This paper discusses an accurate and efficient method for focal plane survey that was used for the Spitzer Space Telescope. The approach is based on using a high-order 37-state Instrument Pointing Frame (IPF) Kalman filter that combines both engineering parameters and science parameters into a single filter formulation. In this approach, engineering parameters such as pointing alignments, thermomechanical drift and gyro drifts are estimated along with science parameters such as plate scales and optical distortions. This integrated approach has many advantages compared to estimating the engineering and science parameters separately. The resulting focal plane survey approach is applicable to a diverse range of science instruments such as imaging cameras, spectroscopy slits, and scanning-type arrays alike. The paper will summarize results from applying the IPF Kalman Filter to calibrating the Spitzer Space Telescope focal plane, containing the MIPS, IRAC, and the IRS science Instrument arrays.

A new measurement method of profile tolerance for the LAMOST focal plane

NASA Astrophysics Data System (ADS)

Zhou, Zengxiang; Jin, Yi; Zhai, Chao; Xing, Xiaozheng

2008-07-01

There were a few methods taken in the profile tolerance measurement of the LAMOST Focal Plane Plate. One of the methods was to use CMM (Coordinate Measurement Machine) to measure the points on the small Focal Plane Plate and calculate the points whether or not in the tolerance zone. In this process there are some small shortcomings. The measuring point positions on the Focal Plane Plate are not the actual installation location of the optical fiber positioning system. In order to eliminate these principle errors, a measuring mandrel is inserted into the unit-holes, and the precision for the mandrel with the hole is controlled in the high level. Then measure the center of the precise target ball which is placed on the measuring mandrel by CMM. At last, fit a sphere surface with the measuring center points of the target ball and analyze the profile tolerance of the Focal Plane Plate. This process will be more in line with the actual installation location of the optical fiber positioning system. When use this method to judge the profile tolerance can provide the reference date for maintaining the ultra error unit-holes on the Focal Plane Plate. But when insert the measuring mandrel into the unit hole, there are manufacturing errors in the measuring mandrel, target ball and assembly errors. All these errors will bring the influence in the measurement. In the paper, an impact evaluation assesses the intermediate process with all these errors through experiments. And the experiment results show that there are little influence when use the target ball and the measuring mandrel in the measurement of the profile tolerance. Instead, there are more advantages than many past use of measuring methods.

SIRTF Focal Plane Survey: A Pre-flight Error Analysis

NASA Technical Reports Server (NTRS)

Bayard, David S.; Brugarolas, Paul B.; Boussalis, Dhemetrios; Kang, Bryan H.

2003-01-01

This report contains a pre-flight error analysis of the calibration accuracies expected from implementing the currently planned SIRTF focal plane survey strategy. The main purpose of this study is to verify that the planned strategy will meet focal plane survey calibration requirements (as put forth in the SIRTF IOC-SV Mission Plan [4]), and to quantify the actual accuracies expected. The error analysis was performed by running the Instrument Pointing Frame (IPF) Kalman filter on a complete set of simulated IOC-SV survey data, and studying the resulting propagated covariances. The main conclusion of this study is that the all focal plane calibration requirements can be met with the currently planned survey strategy. The associated margins range from 3 to 95 percent, and tend to be smallest for frames having a 0.14" requirement, and largest for frames having a more generous 0.28" (or larger) requirement. The smallest margin of 3 percent is associated with the IRAC 3.6 and 5.8 micron array centers (frames 068 and 069), and the largest margin of 95 percent is associated with the MIPS 160 micron array center (frame 087). For pointing purposes, the most critical calibrations are for the IRS Peakup sweet spots and short wavelength slit centers (frames 019, 023, 052, 028, 034). Results show that these frames are meeting their 0.14" requirements with an expected accuracy of approximately 0.1", which corresponds to a 28 percent margin.

The use of integrated focal plane array technologies in laser microsatellite networks

NASA Astrophysics Data System (ADS)

Arnon, Shlomi

2004-10-01

Clustering micro satellites in cooperative fly formation constellations leads to high-performance space systems. The only way to achieve high-speed communication between the satellites is by a laser beam with a narrow divergence angle. In order to make the communication successful three types of focal plane detector arrays are required in the communication terminal: acquisition, tracking and communication detector arrays. The acquisition detector array is used to acquire the neighbor satellite using a wide field-of-view telescope. The tracking detector provides fast, real time and accurate direction location of the neighbor satellite. Based on the information from the acquisition and tracking detectors the receiver and transmitter maintain line of sight. The development of large, fast and very sensitive focal plane detector arrays makes it possible to implement the acquisition, tracking and communication with only one focal plane detector array. By doing so it is possible to reduce dramatically the size, weight, and cost of the optics and electronics which leads to lightweight communication terminals. As a result, the satellites are smaller and lighter, which reduces the space mission cost and increases the booster efficiency. In this paper we will present an overview of the concept of integrated focal plane arrays for laser satellite communication. We also present simulation results based on real system parameters and compare different implementation options.

Charge integration successive approximation analog-to-digital converter for focal plane applications using a single amplifier

NASA Technical Reports Server (NTRS)

Zhou, Zhimin (Inventor); Pain, Bedabrata (Inventor)

1999-01-01

An analog-to-digital converter for on-chip focal-plane image sensor applications. The analog-to-digital converter utilizes a single charge integrating amplifier in a charge balancing architecture to implement successive approximation analog-to-digital conversion. This design requires minimal chip area and has high speed and low power dissipation for operation in the 2-10 bit range. The invention is particularly well suited to CMOS on-chip applications requiring many analog-to-digital converters, such as column-parallel focal-plane architectures.

Focal-plane electric field sensing with pupil-plane holograms

NASA Astrophysics Data System (ADS)

Por, Emiel H.; Keller, Christoph U.

2016-07-01

The direct detection and spectral characterization of exoplanets requires a coronagraph to suppress the diffracted star light. Amplitude and phase aberrations in the optical train fill the dark zone of the coronagraph with quasi-static speckles that limit the achievable contrast. Focal-plane electric field sensing, such as phase diversity introduced by a deformable mirror (DM), is a powerful tool to minimize this residual star light. The residual electric field can be estimated by sequentially applying phase probes on the DM to inject star light with a well-known amplitude and phase into the dark zone and analyzing the resulting intensity images. The DM can then be used to add light with the same amplitude but opposite phase to destructively interfere with this residual star light. Using a static phase-only pupil-plane element we create holographic copies of the point spread function (PSF), each superimposed with a certain pupil-plane phase probe. We therefore obtain all intensity images simultaneously while still retaining a central, unaltered science PSF. The electric field sensing method only makes use of the holographic copies, allowing for correction of the residual electric field while retaining the central PSF for uninterrupted science data collection. In this paper we demonstrate the feasibility of this method with numerical simulations.

High contrast imaging through adaptive transmittance control in the focal plane

NASA Astrophysics Data System (ADS)

Dhadwal, Harbans S.; Rastegar, Jahangir; Feng, Dake

2016-05-01

High contrast imaging, in the presence of a bright background, is a challenging problem encountered in diverse applications ranging from the daily chore of driving into a sun-drenched scene to in vivo use of biomedical imaging in various types of keyhole surgeries. Imaging in the presence of bright sources saturates the vision system, resulting in loss of scene fidelity, corresponding to low image contrast and reduced resolution. The problem is exacerbated in retro-reflective imaging systems where the light sources illuminating the object are unavoidably strong, typically masking the object features. This manuscript presents a novel theoretical framework, based on nonlinear analysis and adaptive focal plane transmittance, to selectively remove object domain sources of background light from the image plane, resulting in local and global increases in image contrast. The background signal can either be of a global specular nature, giving rise to parallel illumination from the entire object surface or can be represented by a mosaic of randomly orientated, small specular surfaces. The latter is more representative of real world practical imaging systems. Thus, the background signal comprises of groups of oblique rays corresponding to distributions of the mosaic surfaces. Through the imaging system, light from group of like surfaces, converges to a localized spot in the focal plane of the lens and then diverges to cast a localized bright spot in the image plane. Thus, transmittance of a spatial light modulator, positioned in the focal plane, can be adaptively controlled to block a particular source of background light. Consequently, the image plane intensity is entirely due to the object features. Experimental image data is presented to verify the efficacy of the methodology.

Static electric polarizabilities and first hyperpolarizabilities of molecular ions RgH + (Rg = He, Ne, Ar, Kr, Xe): ab initio study

NASA Astrophysics Data System (ADS)

Cukras, Janusz; Antušek, Andrej; Holka, Filip; Sadlej, Joanna

2009-06-01

Extensive ab initio calculations of static electric properties of molecular ions of general formula RgH + (Rg = He, Ne, Ar, Kr, Xe) involving the finite field method and coupled cluster CCSD(T) approach have been done. The relativistic effects were taken into account by Douglas-Kroll-Hess approximation. The numerical stability and reliability of calculated values have been tested using the systematic sequence of Dunning's cc-pVXZ-DK and ANO-RCC-VQZP basis sets. The influence of ZPE and pure vibrational contribution has been discussed. The component αzz has increasing trend in RgH + while the relativistic effect on αzz leads to a small increase of this molecular parameter.

The QWIP Focal Plane Assembly for NASA's Landsat Data Continuity Mission

NASA Technical Reports Server (NTRS)

Jhabvala, M.; Reuter, D.; Choi, K.; Sundaram, M.; Jhabvala, C.; La, A.; Waczynski, A.; Bundas, J.

2011-01-01

The Thermal Infrared Sensor (TIRS) is a QWIP based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM). The TIRS instrument is a dual channel far infrared imager with the two bands centered at 10.8 m and 12.0 m. The focal plane assembly (FPA) consists of three 640x512 GaAs Quantum Well Infrared Photodetector (QWIP) arrays precisely mounted to a silicon carrier substrate that is mounted on an invar baseplate. The two spectral bands are defined by bandpass filters mounted in close proximity to the detector surfaces. The focal plane operating temperature is 43K. The QWIP arrays are hybridized to Indigo ISC9803 readout integrated circuits (ROICs). Two varieties of QWIP detector arrays are being developed for this project, a corrugated surface structure QWIP and a grating surface structure QWIP. This paper will describe the TIRS system noise equivalent temperature difference sensitivity as it affects the QWIP focal plane performance requirements: spectral response, dark current, conversion efficiency, read noise, temperature stability, pixel uniformity, optical crosstalk and pixel yield. Additional mechanical constraints as well as qualification through Technology Readiness Level 6 (TRL 6) will also be discussed.

Design study of the accessible focal plane telescope for shuttle

NASA Technical Reports Server (NTRS)

1976-01-01

The design and cost analysis of an accessible focal plane telescope for Spacelab is presented in blueprints, tables, and graphs. Topics covered include the telescope tube, the telescope mounting, the airlock plus Spacelab module aft plate, the instrument adapter, and the instrument package. The system allows access to the image plane with instrumentation that can be operated by a scientist in a shirt sleeve environment inside a Spacelab module.

The QWIP Focal Plane Assembly for NASA's Landsat Data Continuity Mission

NASA Technical Reports Server (NTRS)

Jhabvala, M; Choi, K.; Reuter, D.; Sundaram, M.; Jhabvala, C; La, Anh; Waczynski, Augustyn; Bundas, Jason

2010-01-01

The Thermal Infrared Sensor (TIRS) is a QWIP based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM). The TIRS instrument is a dual channel far infrared imager with the two bands centered at 10.8[mu]m and 12.0[mu]m. The focal plane assembly (FPA) consists of three 640x512 GaAs Quantum Well Infrared Photodetector (QWIP) arrays precisely mounted to a silicon carrier substrate that is mounted on an invar baseplate. The two spectral bands are defined by bandpass filters mounted in close proximity to the detector surfaces. The focal plane operating temperature is 43K. The QWIP arrays are hybridized to Indigo ISC9803 readout integrated circuits (ROICs). Two varieties of QWIP detector arrays are being developed for this project, a corrugated surface structure QWIP and a grating surface structure QWIP. This paper will describe the TIRS system noise equivalent temperature difference sensitivity as it affects the QWIP focal plane performance requirements: spectral response, dark current, conversion efficiency, read noise, temperature stability, pixel uniformity, optical crosstalk and pixel yield. Additional mechanical constraints as well as qualification through Technology Readiness Level 6 (TRL 6) will also be discussed.

Rare Gases Inserted into Biological Building Blocks: A Theoretical Study of Glycine - Rg Compounds (Rg-Xe, Kr, Ar)

NASA Technical Reports Server (NTRS)

Chaban, Galina M.

2005-01-01

Compounds formed by insertion of rare-gas atoms (Xe, Kr, and Ar) into glycine molecule are investigated using accurate ab initio computational methods. Identification of such insertion compounds may open new frontiers in the field of rare-gas chemistry, such as possible existence of biological molecules that include chemically bound rare gas atoms. The most stable glycine-Rg configuration is found to correspond to insertion of Rg atoms into the 0-H bond of glycine. These NH2CH2COORgH compounds are metastable , but separated by sizable potential barriers from the Rg + glycine dissociation products. Preliminary calculations show that NH2CH2COOXeH compound is energetically stable with respect to another (3-body) dissociation channel (NH2CH2COO + Rg + H), while the corresponding Ar species is not stable in this respect. The compound with the inserted Kr is a borderline case, with the 3-body dissociation products being close in energy to the NH2CH2COOKrH minimum.

Analysis of area-time efficiency for an integrated focal plane architecture

NASA Astrophysics Data System (ADS)

Robinson, William H.; Wills, D. Scott

2003-05-01

Monolithic integration of photodetectors, analog-to-digital converters, digital processing, and data storage can improve the performance and efficiency of next-generation portable image products. Our approach combines these components into a single processing element, which is tiled to form a SIMD focal plane processor array with the capability to execute early image applications such as median filtering (noise removal), convolution (smoothing), and inside edge detection (segmentation). Digitizing and processing a pixel at the detection site presents new design challenges, including the allocation of silicon resources. This research investigates the area-time (A"T2) efficiency by adjusting the number of Pixels-per-Processing Element (PPE). Area calculations are based upon hardware implementations of components scaled for 250nm or 120nm technology. The total execution time is calculated from the sequential execution of each application on a generic focal plane architectural simulator. For a Quad-CIF system resolution (176×144), results show that 1 PPE provides the optimal area-time efficiency (5.7 μs2 x mm2 for 250nm, 1.7 μs2 x mm2 for 120nm) but requires a large silicon chip (2072mm2 for 250nm, 614mm2 for 120nm). Increasing the PPE to 4 or 16 can reduce silicon area by 48% and 60% respectively (120nm technology) while maintaining performance within real-time constraints.

Sensor Modelling for the ’Cyclops’ Focal Plane Detector Array Based Technology Demonstrator

DTIC Science & Technology

1992-12-01

Detector Array IFOV Instantaneous field of view IRFPDA Infrared Focal Plane Detector Array LWIR Long-Wave Infrared 0 MCT Mercury Cadmium Telluride MTF...scale focal plane detector array (FPDA). The sensor system operates in the long-wave infrared ( LWIR ) spectral region. The detector array consists of...charge transfer inefficiencies in the readout circuitry. The performance of the HgCdTe FPDA based sensor is limited by the nonuniformity of the

Focal plane transport assembly for the HEAO-B X-ray telescope

NASA Technical Reports Server (NTRS)

Brissette, R.; Allard, P. D.; Keller, F.; Strizhak, E.; Wester, E.

1979-01-01

The High Energy Astronomy Observatory - Mission B (HEAO-B), an earth orbiting X-ray telescope facility capable of locating and imaging celestial X-ray sources within one second of arc in the celestial sphere, is considered. The Focal Plane Transport Assembly (FPTA) is one of the basic structural elements of the three thousand pound HEAO-B experiment payload. The FPTA is a multifunctional assembly which supports seven imaging X-ray detectors circumferentially about a central shaft and accurately positions any particular one into the focus of a high resolution mirror assembly. A drive system, position sensor, rotary coupler, and detent alignment system, all an integral part of the rotatable portion which in turn is supported by main bearings to the stationary focal plane housing are described.

Focal plane subsystem design and performance for atmospheric chemistry from geostationary orbit tropospheric emissions monitoring of pollution

NASA Astrophysics Data System (ADS)

Gilmore, A. S.; Philbrick, R. H.; Funderburg, J.

2017-09-01

Remote sensing of pollutants are enabled from a satellite in a geostationary orbit containing an imaging spectrometer encompassing the wavelength ranges of 290 - 490 nm and 540 - 740 nm. As the first of NASA's Earth Venture Instrument Program, the Tropospheric Emissions: Monitoring of Pollution (TEMPO) program will utilize this instrument to measure hourly air quality over a large portion of North America. The focal plane subsystem (FPS) contains two custom designed and critically aligned full frame transfer charge coupled devices (active area: 1028 x 2048, 18 μm) within a focal plane array package designed for radiation tolerance and space charging rejection. In addition, the FPS contains custom distributed focal plane electronics that provide all necessary clocks and biases to the sensors, receives all analog data from the sensors and performs 14 bit analog to digital conversion for upstream processing. Finally, the FPS encompasses custom low noise cables connecting the focal plane array and associated electronics. This paper discusses the design and performance of this novel focal plane subsystem with particular emphasis on the optical performance achieved including alignment, quantum efficiency, and modulation transfer function.

NGS2: a focal plane array upgrade for the GeMS multiple tip-tilt wavefront sensor

NASA Astrophysics Data System (ADS)

Rigaut, François; Price, Ian; d'Orgeville, Céline; Bennet, Francis; Herrald, Nick; Paulin, Nicolas; Uhlendorf, Kristina; Garrel, Vincent; Sivo, Gaetano; Montes, Vanessa; Trujillo, Chad

2016-07-01

NGS2 is an upgrade for the multi-natural guide star tip-tilt & plate scale wavefront sensor for GeMS (Gemini Multi-Conjugate Adaptive Optics system). It uses a single Nüvü HNü-512 Electron-Multiplied CCD array that spans the entire GeMS wavefront sensor focal plane. Multiple small regions-of-interest are used to enable frame rates up to 800Hz. This set up will improve the optical throughput with respect to the current wavefront sensor, as well as streamline acquisition and allow for distortion compensation.

Optical Characterization of the SPT-3G Focal Plane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pan, Z.; et al.

The third-generation South Pole Telescope camera is designed to measure the cosmic microwave background across three frequency bands (95, 150 and 220 GHz) with ~16,000 transition-edge sensor (TES) bolometers. Each multichroic pixel on a detector wafer has a broadband sinuous antenna that couples power to six TESs, one for each of the three observing bands and both polarization directions, via lumped element filters. Ten detector wafers populate the focal plane, which is coupled to the sky via a large-aperture optical system. Here we present the frequency band characterization with Fourier transform spectroscopy, measurements of optical time constants, beam properties, andmore » optical and polarization efficiencies of the focal plane. The detectors have frequency bands consistent with our simulations, and have high average optical efficiency which is 86%, 77% and 66% for the 95, 150 and 220 GHz detectors. The time constants of the detectors are mostly between 0.5 ms and 5 ms. The beam is round with the correct size, and the polarization efficiency is more than 90% for most of the bolometers« less

Verification of the Sentinel-4 focal plane subsystem

NASA Astrophysics Data System (ADS)

Williges, Christian; Uhlig, Mathias; Hilbert, Stefan; Rossmann, Hannes; Buchwinkler, Kevin; Babben, Steffen; Sebastian, Ilse; Hohn, Rüdiger; Reulke, Ralf

2017-09-01

The Sentinel-4 payload is a multi-spectral camera system, designed to monitor atmospheric conditions over Europe from a geostationary orbit. The German Aerospace Center, DLR Berlin, conducted the verification campaign of the Focal Plane Subsystem (FPS) during the second half of 2016. The FPS consists, of two Focal Plane Assemblies (FPAs), two Front End Electronics (FEEs), one Front End Support Electronic (FSE) and one Instrument Control Unit (ICU). The FPAs are designed for two spectral ranges: UV-VIS (305 nm - 500 nm) and NIR (750 nm - 775 nm). In this publication, we will present in detail the set-up of the verification campaign of the Sentinel-4 Qualification Model (QM). This set up will also be used for the upcoming Flight Model (FM) verification, planned for early 2018. The FPAs have to be operated at 215 K +/- 5 K, making it necessary to exploit a thermal vacuum chamber (TVC) for the test accomplishment. The test campaign consists mainly of radiometric tests. This publication focuses on the challenge to remotely illuminate both Sentinel-4 detectors as well as a reference detector homogeneously over a distance of approximately 1 m from outside the TVC. Selected test analyses and results will be presented.

Producibility of Vertically Integrated Photodiode (VIP)tm scanning focal plane arrays

NASA Astrophysics Data System (ADS)

Turner, Arthur M.; Teherani, Towfik; Ehmke, John C.; Pettitt, Cindy; Conlon, Peggy; Beck, Jeffrey D.; McCormack, Kent; Colombo, Luigi; Lahutsky, Tom; Murphy, Terry; Williams, Robert L.

1994-07-01

Vertically integrated photodiode, VIPTM, technology is now being used to produce second generation infrared focal plane arrays with high yields and performance. The VIPTM process employs planar, ion implanted, n on p diodes in HgCdTe which is epoxy hybridized directly to the read out integrated circuits on 100 mm Si wafers. The process parameters that are critical for high performance and yield include: HgCdTe dislocation density and thickness, backside passivation, frontside passivation, and junction formation. Producibility of infrared focal plane arrays (IRFPAs) is also significantly enhanced by read out integrated circuits (ROICs) which have the ability to deselect defective pixels. Cold probe screening before lab dewar assembly reduces costs and improves cycle times. The 240 X 1 and 240 X 2 scanning array formats are used to demonstrate the effect of process optimization, deselect, and cold probe screening on yield and cycle time. The versatility of the VIPTM technology and its extension to large area arrays is demonstrated using 240/288 X 4 and 480 X 5 TDI formats. Finally, the high performance of VIPTM IRFPAs is demonstrated by comparing data from a 480 X 5 to the SADA-II specification.

Focal-plane detector system for the KATRIN experiment

NASA Astrophysics Data System (ADS)

Amsbaugh, J. F.; Barrett, J.; Beglarian, A.; Bergmann, T.; Bichsel, H.; Bodine, L. I.; Bonn, J.; Boyd, N. M.; Burritt, T. H.; Chaoui, Z.; Chilingaryan, S.; Corona, T. J.; Doe, P. J.; Dunmore, J. A.; Enomoto, S.; Formaggio, J. A.; Fränkle, F. M.; Furse, D.; Gemmeke, H.; Glück, F.; Harms, F.; Harper, G. C.; Hartmann, J.; Howe, M. A.; Kaboth, A.; Kelsey, J.; Knauer, M.; Kopmann, A.; Leber, M. L.; Martin, E. L.; Middleman, K. J.; Myers, A. W.; Oblath, N. S.; Parno, D. S.; Peterson, D. A.; Petzold, L.; Phillips, D. G.; Renschler, P.; Robertson, R. G. H.; Schwarz, J.; Steidl, M.; Tcherniakhovski, D.; Thümmler, T.; Van Wechel, T. D.; VanDevender, B. A.; Vöcking, S.; Wall, B. L.; Wierman, K. L.; Wilkerson, J. F.; Wüstling, S.

2015-04-01

The focal-plane detector system for the KArlsruhe TRItium Neutrino (KATRIN) experiment consists of a multi-pixel silicon p-i-n-diode array, custom readout electronics, two superconducting solenoid magnets, an ultra high-vacuum system, a high-vacuum system, calibration and monitoring devices, a scintillating veto, and a custom data-acquisition system. It is designed to detect the low-energy electrons selected by the KATRIN main spectrometer. We describe the system and summarize its performance after its final installation.

Experimental realization of a metamaterial detector focal plane array.

PubMed

Shrekenhamer, David; Xu, Wangren; Venkatesh, Suresh; Schurig, David; Sonkusale, Sameer; Padilla, Willie J

2012-10-26

We present a metamaterial absorber detector array that enables room-temperature, narrow-band detection of gigahertz (GHz) radiation in the S band (2-4 GHz). The system is implemented in a commercial printed circuit board process and we characterize the detector sensitivity and angular dependence. A modified metamaterial absorber geometry allows for each unit cell to act as an isolated detector pixel and to collectively form a focal plane array . Each pixel can have a dedicated microwave receiver chain and functions together as a hybrid device tuned to maximize the efficiency of detected power. The demonstrated subwavelength pixel shows detected sensitivity of -77 dBm, corresponding to a radiation power density of 27 nW/m(2), with pixel to pixel coupling interference below -14 dB at 2.5 GHz.

Precise annealing of focal plane arrays for optical detection

DOEpatents

Bender, Daniel A.

2015-09-22

Precise annealing of identified defective regions of a Focal Plane Array ("FPA") (e.g., exclusive of non-defective regions of the FPA) facilitates removal of defects from an FPA that has been hybridized and/or packaged with readout electronics. Radiation is optionally applied under operating conditions, such as under cryogenic temperatures, such that performance of an FPA can be evaluated before, during, and after annealing without requiring thermal cycling.

Precise annealing of focal plane arrays for optical detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bender, Daniel A.

2017-10-17

Precise annealing of identified defective regions of a Focal Plane Array ("FPA") (e.g., exclusive of non-defective regions of the FPA) facilitates removal of defects from an FPA that has been hybridized and/or packaged with readout electronics. Radiation is optionally applied under operating conditions, such as under cryogenic temperatures, such that performance of an FPA can be evaluated before, during, and after annealing without requiring thermal cycling.

Effect of the focal plane position on CO2 laser beam cutting of injection molded polycarbonate sheets

NASA Astrophysics Data System (ADS)

Moradi, Mahmoud; Mehrabi, Omid; Azdast, Taher; Benyounis, Khaled Y.

2016-11-01

In the present research, the effect of laser beam focal plane position (FPP) on the kerf quality of the polycarbonate laser cutting is investigated. Low power CO2 laser is used as the heat source of the cutting runs. In the experiments, FPP is varied from 0 to -4mm while other processing parameters (i.e. laser power, cutting speed and gas pressure) are considered constant. Upper and lower kerf width, kerf taper, upper heat affected zone and surface roughness of the kerf wall are also considered as the responses. Observations signified that reducing the position of the laser beam focal point from zero to - 3mm reduces the upper and lower kerf width. However reducing FPP below -3mm leads to an increase in the kerf width. Results also reveals that upper heat affected zone value reduces by reduction in FPP. Moreover the best kerf wall surface roughness occurred at FPP= -3mm.

BER Analysis of Coherent Free-Space Optical Communication Systems with a Focal-Plane-Based Wavefront Sensor

NASA Astrophysics Data System (ADS)

Cao, Jingtai; Zhao, Xiaohui; Liu, Wei; Gu, Haijun

2018-03-01

A wavefront sensor is one of most important units for an adaptive optics system. Based on our previous works, in this paper, we discuss the bit-error-rate (BER) performance of coherent free space optical communication systems with a focal-plane-based wavefront sensor. Firstly, the theory of a focal-plane-based wavefront sensor is given. Then the relationship between the BER and the mixing efficiency with a homodyne receiver is discussed on the basis of binary-phase-shift-keying (BPSK) modulation. Finally, the numerical simulation results are shown that the BER will be decreased obviously after aberrations correction with the focal-plane-based wavefront sensor. In addition, the BER will decrease along with increasing number of photons received within a single bit. These analysis results will provide a reference for the design of the coherent Free space optical communication (FSOC) system.

Modulation transfer function measurement of microbolometer focal plane array by Lloyd's mirror method

NASA Astrophysics Data System (ADS)

Druart, Guillaume; Rommeluere, Sylvain; Viale, Thibault; Guerineau, Nicolas; Ribet-Mohamed, Isabelle; Crastes, Arnaud; Durand, Alain; Taboury, Jean

2014-05-01

Today, both military and civilian applications require miniaturized and cheap optical systems. One way to achieve this trend consists in decreasing the pixel pitch of focal plane arrays (FPA). In order to evaluate the performance of the overall optical systems, it is necessary to measure the modulation transfer function (MTF) of these pixels. However, small pixels lead to higher cut-off frequencies and therefore, original MTF measurements that are able to extract frequencies up to these high cut-off frequencies, are needed. In this paper, we will present a way to extract 1D MTF at high frequencies by projecting fringes on the FPA. The device uses a Lloyd mirror placed near and perpendicular to the focal plane array. Consequently, an interference pattern of fringes can be projected on the detector. By varying the angle of incidence of the light beam, we can tune the period of the interference fringes and, thus, explore a wide range of spatial frequencies, and mainly around the cut-off frequency of the pixel which is one of the most interesting area. Illustration of this method will be applied to a 640×480 microbolometer focal plane array with a pixel pitch of 17µm in the LWIR spectral region.

Status and Integrated Focal Plane Characterization of Simons Array - Cosmic Microwave Background Polarimetry Experiment

NASA Astrophysics Data System (ADS)

Roberts, Hayley; POLARBEAR

2018-06-01

Simons Array is a cosmic microwave background (CMB) polarization experiment located at 5,200 meter altitude site in the Atacama desert in Chile. The science goals of the Simons Array are to characterize the CMB B-mode signal from gravitational lensing, and search for B-mode polarization generated from inflationary gravitational waves.In 2012, POLARBEAR-1 (PB-1) began observations and the POLARBEAR team has published the first measurements of non-zero polarization B-mode polarization angular power spectrum where gravitational lensing of CMB is the dominant signal.POLARBEAR-2A (PB-2A), the first of three receivers of Simons Array, will have 7,588 polarization sensitive Transition Edge Sensor (TES) bolometers with frequencies 90 GHz and 150 GHz. This represents a factor of 6 increase in detector count compared to PB-1. Once Simons Array is fully deployed, the focal plane array will consist 22,764 TES bolometers across 90 GHz, 150 GHz, 220 GHz, and 270 GHz with a projected instantaneous sensitivity of 2.5 µK√s. Here we present the status of PB-2A and characterization of the integrated focal plane to be deployed summer of 2018.

The study of multilayer anti-reflection coating in InSb focal plane detector

NASA Astrophysics Data System (ADS)

Zheng, Kelin; Wei, Peng; Wang, Liwen; Su, Xianjun; Wang, Haizhen

2016-10-01

In manufacturing of InSb focal plane detector, InSb chip have to be polished from backside to reduce its thickness and then be plated a layer of coating to decrease its reflection (enhance its transmittance) for infrared ray. Moreover, the anti-reflection coating has to be multilayer for more anti-reflection bandwidth. In this article, it is introduced that the optimal design of triple layer λ/4 anti-reflection coating——the anodic oxide, SiNx and MgF2. The best thickness range of each layer and its theoretical reflective index are calculated from simulation software, until the refractive index of each layer has been measured by ellipsometer. And then the transmissivity and reflectivity of the triple layer coating are measured for testing and verifying its performance on the transmittance and reflection. In the end, the anti-reflective effect of the triple layer coating and monolayer SiNx coating are respectively measured and compared by infrared focal plane array measurement system. And it is showed that this triple layer coating achieved more anti-reflection bandwidth and better anti reflective effect.

Development of 640 X 480 LWIR focal plane arrays

NASA Astrophysics Data System (ADS)

Shallcross, Frank V.; Meyerhofer, Dietrich; Dolny, Gary M.; Gilmartin, Harvey R.; Tower, John R.; Palfrey, Stephen L.

1992-08-01

The 640 X 480 MOS multiplexer developed for PtSi MWIR focal plane arrays has been adapted to LWIR operation. The multiplexer is very flexible and can be used in various operating modes. The MOS approach, with its high saturation capacity and low-temperature operating capability, is ideally suited for long-wavelength operation. In this paper applications of the multiplexer to IrSi Schottky detectors and SiGe heterojunction detectors are discussed.

High Sensitivity Long-Wavelength Infrared QWIP Focal Plane Array Based Instrument for Remote Sensing of Icy Satellites

NASA Technical Reports Server (NTRS)

Gunapala, S.; Bandara, S.; Ivanov, A.

2003-01-01

GaAs based Quantum Well Infrared Photodetector (QWIP) technology has shown remarkable success in advancing low cost, highly uniform, high-operability, large format multi-color focal plane arrays. QWIPs afford greater flexibility than the usual extrinsically doped semiconductor IR detectors. The wavelength of the peak response and cutoff can be continuously tailored over a range wide enough to enable light detection at any wavelength range between 6 and 20 micron. The spectral band-width of these detectors can be tuned from narrow (Deltalambda/lambda is approximately 10%) to wide (Deltalambda/lambda is approximately 40%) allowing various applications. Furthermore, QWIPs offer low cost per pixel and highly uniform large format focal plane arrays due to mature GaAs/AlGaAs growth and processing technologies. The other advantages of GaAs/AlGaAs based QWIPS are higher yield, lower l/f noise and radiation hardness (1.5 Mrad). In this presentation, we will discuss our recent demonstrations of 640x512 pixel narrow-band, broad-band, multi-band focal plane arrays, and the current status of the development of 1024x1024 pixel long-wavelength infrared QWIP focal plane arrays.

A focal plane detector design for a wide band Laue-lens telescope

NASA Astrophysics Data System (ADS)

Caroli, E.; Auricchio, N.; Bertuccio, G.; Budtz-Jørgensen, C.; Curado da Silva, R. M.; Del Sordo, S.; Frontera, F.; Quadrini, E.; Ubertini, P.; Ventura, G.

2006-06-01

The energy range above 50 keV is important for the study of many open problems in high energy astrophysics such as, non thermal mechanisms in SNR, the study of the high energy cut-offs in AGN spectra, and the detection of nuclear and annihilation lines. In the framework of the definition of a new mission concept for hard X and soft gamma ray (GRI- Gamma Ray Imager) for the next decade, the use of Laue lenses with broad energy band-passes from 100 to 1000 keV is under study. This kind of instruments will be used for deep study the hard X-ray continuum of celestial sources. This new telescope will require focal plane detectors with high detection efficiency over the entire operative range, an energy resolution of few keV at 500 keV and a sensitivity to linear polarization. We describe a possible configuration for the focal plane detector based on CdTe/CZT pixelated layers stacked together to achieve the required detection efficiency at high energy. Each layer can either operate as a separate position sensitive detector and a polarimeter or together with other layers in order to increase the overall full energy efficiency. We report on the current state of art in high Z spectrometers development and on some activities undergoing. Furthermore we describe the proposed focal plane option with the required resources and an analytical summary of the achievable performance in terms of efficiency and polarimetry.

Monolithic in-based III-V compound semiconductor focal plane array cell with single stage CCD output

NASA Technical Reports Server (NTRS)

Fossum, Eric R. (Inventor); Cunningham, Thomas J. (Inventor); Krabach, Timothy N. (Inventor); Staller, Craig O. (Inventor)

1994-01-01

A monolithic semiconductor imager includes an indium-based III-V compound semiconductor monolithic active layer of a first conductivity type, an array of plural focal plane cells on the active layer, each of the focal plane cells including a photogate over a top surface of the active layer, a readout circuit dedicated to the focal plane cell including plural transistors formed monolithically with the monolithic active layer and a single-stage charge coupled device formed monolithically with the active layer between the photogate and the readout circuit for transferring photo-generated charge accumulated beneath the photogate during an integration period to the readout circuit. The photogate includes thin epitaxial semiconductor layer of a second conductivity type overlying the active layer and an aperture electrode overlying a peripheral portion of the thin epitaxial semiconductor layer, the aperture electrode being connectable to a photogate bias voltage.

PNIC - A near infrared camera for testing focal plane arrays

NASA Astrophysics Data System (ADS)

Hereld, Mark; Harper, D. A.; Pernic, R. J.; Rauscher, Bernard J.

1990-07-01

This paper describes the design and the performance of the Astrophysical Research Consortium prototype near-infrared camera (pNIC) designed to test focal plane arrays both on and off the telescope. Special attention is given to the detector in pNIC, the mechanical and optical designs, the electronics, and the instrument interface. Experiments performed to illustrate the most salient aspects of pNIC are described.

Focal plane wavefront sensor achromatization: The multireference self-coherent camera

NASA Astrophysics Data System (ADS)

Delorme, J. R.; Galicher, R.; Baudoz, P.; Rousset, G.; Mazoyer, J.; Dupuis, O.

2016-04-01

Context. High contrast imaging and spectroscopy provide unique constraints for exoplanet formation models as well as for planetary atmosphere models. But this can be challenging because of the planet-to-star small angular separation (<1 arcsec) and high flux ratio (>105). Recently, optimized instruments like VLT/SPHERE and Gemini/GPI were installed on 8m-class telescopes. These will probe young gazeous exoplanets at large separations (≳1 au) but, because of uncalibrated phase and amplitude aberrations that induce speckles in the coronagraphic images, they are not able to detect older and fainter planets. Aims: There are always aberrations that are slowly evolving in time. They create quasi-static speckles that cannot be calibrated a posteriori with sufficient accuracy. An active correction of these speckles is thus needed to reach very high contrast levels (>106-107). This requires a focal plane wavefront sensor. Our team proposed a self coherent camera, the performance of which was demonstrated in the laboratory. As for all focal plane wavefront sensors, these are sensitive to chromatism and we propose an upgrade that mitigates the chromatism effects. Methods: First, we recall the principle of the self-coherent camera and we explain its limitations in polychromatic light. Then, we present and numerically study two upgrades to mitigate chromatism effects: the optical path difference method and the multireference self-coherent camera. Finally, we present laboratory tests of the latter solution. Results: We demonstrate in the laboratory that the multireference self-coherent camera can be used as a focal plane wavefront sensor in polychromatic light using an 80 nm bandwidth at 640 nm (bandwidth of 12.5%). We reach a performance that is close to the chromatic limitations of our bench: 1σ contrast of 4.5 × 10-8 between 5 and 17 λ0/D. Conclusions: The performance of the MRSCC is promising for future high-contrast imaging instruments that aim to actively minimize the

Two-dimensional tracking of ncd motility by back focal plane interferometry.

PubMed Central

Allersma, M W; Gittes, F; deCastro, M J; Stewart, R J; Schmidt, C F

1998-01-01

A technique for detecting the displacement of micron-sized optically trapped probes using far-field interference is introduced, theoretically explained, and used to study the motility of the ncd motor protein. Bead motions in the focal plane relative to the optical trap were detected by measuring laser intensity shifts in the back-focal plane of the microscope condenser by projection on a quadrant diode. This detection method is two-dimensional, largely independent of the position of the trap in the field of view and has approximately 10-micros time resolution. The high resolution makes it possible to apply spectral analysis to measure dynamic parameters such as local viscosity and attachment compliance. A simple quantitative theory for back-focal-plane detection was derived that shows that the laser intensity shifts are caused primarily by a far-field interference effect. The theory predicts the detector response to bead displacement, without adjustable parameters, with good accuracy. To demonstrate the potential of the method, the ATP-dependent motility of ncd, a kinesin-related motor protein, was observed with an in vitro bead assay. A fusion protein consisting of truncated ncd (amino acids 195-685) fused with glutathione-S-transferase was adsorbed to silica beads, and the axial and lateral motions of the beads along the microtubule surface were observed with high spatial and temporal resolution. The average axial velocity of the ncd-coated beads was 230 +/- 30 nm/s (average +/- SD). Spectral analysis of bead motion showed the increase in viscous drag near the surface; we also found that any elastic constraints of the moving motors are much smaller than the constraints due to binding in the presence of the nonhydrolyzable nucleotide adenylylimidodiphosphate. PMID:9533719

Multiscale multichroic focal planes for measurements of the cosmic microwave background

NASA Astrophysics Data System (ADS)

Cukierman, Ari; Lee, Adrian T.; Raum, Christopher; Suzuki, Aritoki; Westbrook, Benjamin

2018-01-01

We report on the development of multiscale multichroic focal planes for measurements of the cosmic microwave background (CMB). A multichroic focal plane, i.e., one that consists of pixels that are simultaneously sensitive in multiple frequency bands, is an efficient architecture for increasing the sensitivity of an experiment as well as for disentangling the contamination due to galactic foregrounds, which is increasingly becoming the limiting factor in extracting cosmological information from CMB measurements. To achieve these goals, it is necessary to observe across a broad frequency range spanning roughly 30-350 GHz. For this purpose, the Berkeley CMB group has been developing multichroic pixels consisting of planar superconducting sinuous antennas coupled to extended hemispherical lenslets, which operate at sub-Kelvin temperatures. The sinuous antennas, microwave circuitry and the transition-edge-sensor (TES) bolometers to which they are coupled are integrated in a single lithographed wafer.We describe the design, fabrication, testing and performance of multichroic pixels with bandwidths of 3:1 and 4:1 across the entire frequency range of interest. Additionally, we report on a demonstration of multiscale pixels, i.e., pixels whose effective size changes as a function of frequency. This property keeps the beam width approximately constant across all frequencies, which in turn allows the sensitivity of the experiment to be optimal in every frequency band. We achieve this by creating phased arrays from neighboring lenslet-coupled sinuous antennas, where the size of each phased array is chosen independently for each frequency band. We describe the microwave circuitry in detail as well as the benefits of a multiscale architecture, e.g., mitigation of beam non-idealities, reduced readout requirements, etc. Finally, we discuss the design and fabrication of the detector modules and focal-plane structures including cryogenic readout components, which enable the

Persistence characterization and data calibration scheme for the RSS-NIR H2RG detector on SALT

NASA Astrophysics Data System (ADS)

Mosby, Gregory; Eggen, Nathan; Wolf, Marsha; Jaehnig, Kurt; Kotulla, Ralf

2016-07-01

The University of Wisconsin Madison is building a NIR spectrograph (RSS-NIR) for the Southern African Large Telescope. The detector system uses a H2RG HdCdTe 1.7 μm cutoff array. We performed tests to measure and characterize the persistence of the detector to inform strategies to mitigate this effect. These tests use up-the- ramp group samples to get finer time resolution of the release of persistence. We share these test results. We also present preliminary results of the dependence of persistence on detector temperature. We conclude with an outline and assessment of a persistence calibration scheme.

Test results of Spacelab 2 infrared telescope focal plane. [photoconductive detector fabrication and JFET transimpedance amplifier design

NASA Technical Reports Server (NTRS)

Young, E. T.; Rieke, G. H.; Gautier, T. N.; Hoffmann, W. F.; Low, F. J.; Poteet, W.; Fazio, G. G.; Koch, D.; Traub, W. A.; Urban, E. W.

1981-01-01

The small helium cooled infrared telescope for Spacelab 2 is designed for sensitive mapping of extended, low-surface-brightness celestial sources as well as highly sensitive investigations of the shuttle contamination environment (FPA) for this mission is described as well as the design for a thermally isolated, self-heated J-FET transimpedance amplifier. This amplifier is Johnson noise limited for feedback resistances from less than 10 to the 8th power Omega to greater than 2 x 10 to the 10th power Omega at T = 4.2K. Work on the focal plane array is complete. Performance testing for qualification of the flight hardware is discussed, and results are presented. All infrared data channels are measured to be background limited by the expected level of zodiacal emission.

Scene-based nonuniformity correction for focal plane arrays by the method of the inverse covariance form.

PubMed

Torres, Sergio N; Pezoa, Jorge E; Hayat, Majeed M

2003-10-10

What is to our knowledge a new scene-based algorithm for nonuniformity correction in infrared focal-plane array sensors has been developed. The technique is based on the inverse covariance form of the Kalman filter (KF), which has been reported previously and used in estimating the gain and bias of each detector in the array from scene data. The gain and the bias of each detector in the focal-plane array are assumed constant within a given sequence of frames, corresponding to a certain time and operational conditions, but they are allowed to randomly drift from one sequence to another following a discrete-time Gauss-Markov process. The inverse covariance form filter estimates the gain and the bias of each detector in the focal-plane array and optimally updates them as they drift in time. The estimation is performed with considerably higher computational efficiency than the equivalent KF. The ability of the algorithm in compensating for fixed-pattern noise in infrared imagery and in reducing the computational complexity is demonstrated by use of both simulated and real data.

Image interpolation and denoising for division of focal plane sensors using Gaussian processes.

PubMed

Gilboa, Elad; Cunningham, John P; Nehorai, Arye; Gruev, Viktor

2014-06-16

Image interpolation and denoising are important techniques in image processing. These methods are inherent to digital image acquisition as most digital cameras are composed of a 2D grid of heterogeneous imaging sensors. Current polarization imaging employ four different pixelated polarization filters, commonly referred to as division of focal plane polarization sensors. The sensors capture only partial information of the true scene, leading to a loss of spatial resolution as well as inaccuracy of the captured polarization information. Interpolation is a standard technique to recover the missing information and increase the accuracy of the captured polarization information. Here we focus specifically on Gaussian process regression as a way to perform a statistical image interpolation, where estimates of sensor noise are used to improve the accuracy of the estimated pixel information. We further exploit the inherent grid structure of this data to create a fast exact algorithm that operates in ����(N(3/2)) (vs. the naive ���� (N³)), thus making the Gaussian process method computationally tractable for image data. This modeling advance and the enabling computational advance combine to produce significant improvements over previously published interpolation methods for polarimeters, which is most pronounced in cases of low signal-to-noise ratio (SNR). We provide the comprehensive mathematical model as well as experimental results of the GP interpolation performance for division of focal plane polarimeter.

Multiwavelength infrared focal plane array detector

NASA Technical Reports Server (NTRS)

Forrest, Stephen R. (Inventor); Olsen, Gregory H. (Inventor); Kim, Dong-Su (Inventor); Lange, Michael J. (Inventor)

1995-01-01

A multiwavelength focal plane array infrared detector is included on a common substrate having formed on its top face a plurality of In.sub.x Ga.sub.1-x As (x.ltoreq.0.53) absorption layers, between each pair of which a plurality of InAs.sub.y P.sub.1-y (y<1) buffer layers are formed having substantially increasing lattice parameters, respectively, relative to said substrate, for preventing lattice mismatch dislocations from propagating through successive ones of the absorption layers of decreasing bandgap relative to said substrate, whereby a plurality of detectors for detecting different wavelengths of light for a given pixel are provided by removing material above given areas of successive ones of the absorption layers, which areas are doped to form a pn junction with the surrounding unexposed portions of associated absorption layers, respectively, with metal contacts being formed on a portion of each of the exposed areas, and on the bottom of the substrate for facilitating electrical connections thereto.

Focal-Plane Imaging of Crossed Beams in Nonlinear Optics Experiments

NASA Technical Reports Server (NTRS)

Bivolaru, Daniel; Herring, G. C.

2007-01-01

An application of focal-plane imaging that can be used as a real time diagnostic of beam crossing in various optical techniques is reported. We discuss two specific versions and demonstrate the capability of maximizing system performance with an example in a combined dual-pump coherent anti-Stokes Raman scattering interferometric Rayleigh scattering experiment (CARS-IRS). We find that this imaging diagnostic significantly reduces beam alignment time and loss of CARS-IRS signals due to inadvertent misalignments.

Exploiting Satellite Focal Plane Geometry for Automatic Extraction of Traffic Flow from Single Optical Satellite Imagery

NASA Astrophysics Data System (ADS)

Krauß, T.

2014-11-01

The focal plane assembly of most pushbroom scanner satellites is built up in a way that different multispectral or multispectral and panchromatic bands are not all acquired exactly at the same time. This effect is due to offsets of some millimeters of the CCD-lines in the focal plane. Exploiting this special configuration allows the detection of objects moving during this small time span. In this paper we present a method for automatic detection and extraction of moving objects - mainly traffic - from single very high resolution optical satellite imagery of different sensors. The sensors investigated are WorldView-2, RapidEye, Pléiades and also the new SkyBox satellites. Different sensors require different approaches for detecting moving objects. Since the objects are mapped on different positions only in different spectral bands also the change of spectral properties have to be taken into account. In case the main distance in the focal plane is between the multispectral and the panchromatic CCD-line like for Pléiades an approach for weighted integration to receive mostly identical images is investigated. Other approaches for RapidEye and WorldView-2 are also shown. From these intermediate bands difference images are calculated and a method for detecting the moving objects from these difference images is proposed. Based on these presented methods images from different sensors are processed and the results are assessed for detection quality - how many moving objects can be detected, how many are missed - and accuracy - how accurate is the derived speed and size of the objects. Finally the results are discussed and an outlook for possible improvements towards operational processing is presented.

HM{sup +}–RG complexes (M = group 2 metal; RG = rare gas): Physical vs. chemical interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, Joe P.; Dodson, Hannah; Wright, Timothy G., E-mail: Tim.Wright@nottingham.ac.uk

2015-04-21

Previous work on the HM{sup +}–He complexes (M = Be–Ra) has been extended to the cases of the heavier rare gas atoms, HM{sup +}–RG (RG = Ne–Rn). Optimized geometries and harmonic vibrational frequencies have been calculated using MP2 theory and quadruple-ζ quality basis sets. Dissociation energies for the loss of the rare gas atom have been calculated at these optimized geometries using coupled cluster with single and double excitations and perturbative triples, CCSD(T)theory, extrapolating interaction energies to the basis set limit. Comparisons are made between the present data and the previously obtained helium results, as well as to those ofmore » the bare HM{sup +} molecules; furthermore, comparisons are made to the related M{sup +}–RG and M{sup 2+}–RG complexes. Partial atomic charge analyses have also been undertaken, and these used to test a simple charge-induced dipole model. Molecular orbital diagrams are presented together with contour plots of the natural orbitals from the quadratic configuration with single and double excitations (QCISD) density. The conclusion is that the majority of these complexes are physically bound, with very little sharing of electron density; however, for M = Be, and to a lesser extent M = Mg, some evidence for chemical effects is seen in HM{sup +}–RG complexes involving RG atoms with the higher atomic numbers.« less

High precise measurement of tiny angle dimensional holes for the unit-holes of the LAMOST Focal Plane Plate

NASA Astrophysics Data System (ADS)

Zhou, Zengxiang; Jin, Yi; Zhai, Chao; Xing, Xiaozheng

2008-07-01

In the LAMOST project, the unit-holes on the Focal Plane Plate are the final installation location of the optical fiber positioning system. Theirs precision will influence the observation efficiency of the LAMOST. For the unique requirements, the unit-holes on the Focal Plane Plate are composed by a series of tiny angle dimensional holes which dimensional angle are between 16' to 2.5°. According to these requirements, the measurement of the tiny angle dimensional holes for the unit-holes needs to less than 3'. And all the unit-holes point to the virtual sphere center of the Focal Plane Plate. To that end, the angle departure of the unit-holes axis is changed to the distance from the virtual sphere center of Focal Plane Plate to the unit-holes axis. That is the better way to evaluate the technical requirements of the dimensional angle errors. In the measuring process, common measuring methods do not fit for the tiny angle dimensional hole by CMM(coordinate measurement machine). An extraordinary way to solve this problem is to insert a measuring stick into a unit-hole, with a target ball on the stick. Then measure the low point of the ball center and pull out the stick for the high station of center. Finally, calculate the two points for the unit-hole axis to get the angle departure. But on the other hand, use this methods will bring extra errors for the measuring stick and the target ball. For better analysis this question, a series experiments are mentioned in this paper, which testify that the influence of the measure implement is little. With increasing the distance between the low point and the high point position in the measuring process should enhance the accuracy of dimensional angle measurement.

Validating Phasing and Geometry of Large Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Standley, Shaun P.; Gautier, Thomas N.; Caldwell, Douglas A.; Rabbette, Maura

2011-01-01

The Kepler Mission is designed to survey our region of the Milky Way galaxy to discover hundreds of Earth-sized and smaller planets in or near the habitable zone. The Kepler photometer is an array of 42 CCDs (charge-coupled devices) in the focal plane of a 95-cm Schmidt camera onboard the Kepler spacecraft. Each 50x25-mm CCD has 2,200 x 1,024 pixels. The CCDs accumulate photons and are read out every six seconds to prevent saturation. The data is integrated for 30 minutes, and then the pixel data is transferred to onboard storage. The data is subsequently encoded and transmitted to the ground. During End-to-End Information System (EEIS) testing of the Kepler Mission System (KMS), there was a need to verify that the pixels requested by the science team operationally were correctly collected, encoded, compressed, stored, and transmitted by the FS, and subsequently received, decoded, uncompressed, and displayed by the Ground Segment (GS) without the outputs of any CCD modules being flipped, mirrored, or otherwise corrupted during the extensive FS and GS processing. This would normally be done by projecting an image on the focal plane array (FPA), collecting the data in a flight-like way, and making a comparison between the original data and the data reconstructed by the science data system. Projecting a focused image onto the FPA through the telescope would normally involve using a collimator suspended over the telescope opening. There were several problems with this approach: the collimation equipment is elaborate and expensive; as conceived, it could only illuminate a limited section of the FPA (.25 percent) during a given test; the telescope cover would have to be deployed during testing to allow the image to be projected into the telescope; the equipment was bulky and difficult to situate in temperature-controlled environments; and given all the above, test setup, execution, and repeatability were significant concerns. Instead of using this complicated approach of

An efficient shutter-less non-uniformity correction method for infrared focal plane arrays

NASA Astrophysics Data System (ADS)

Huang, Xiyan; Sui, Xiubao; Zhao, Yao

2017-02-01

The non-uniformity response in infrared focal plane array (IRFPA) detectors has a bad effect on images with fixed pattern noise. At present, it is common to use shutter to prevent from radiation of target and to update the parameters of non-uniformity correction in the infrared imaging system. The use of shutter causes "freezing" image. And inevitably, there exists the problems of the instability and reliability of system, power consumption, and concealment of infrared detection. In this paper, we present an efficient shutter-less non-uniformity correction (NUC) method for infrared focal plane arrays. The infrared imaging system can use the data gaining in thermostat to calculate the incident infrared radiation by shell real-timely. And the primary output of detector except the shell radiation can be corrected by the gain coefficient. This method has been tested in real infrared imaging system, reaching high correction level, reducing fixed pattern noise, adapting wide temperature range.

Experimental implementations of 2D IR spectroscopy through a horizontal pulse shaper design and a focal plane array detector

PubMed Central

Ghosh, Ayanjeet; Serrano, Arnaldo L.; Oudenhoven, Tracey A.; Ostrander, Joshua S.; Eklund, Elliot C.; Blair, Alexander F.; Zanni, Martin T.

2017-01-01

Aided by advances in optical engineering, two-dimensional infrared spectroscopy (2D IR) has developed into a promising method for probing structural dynamics in biophysics and material science. We report two new advances for 2D IR spectrometers. First, we report a fully reflective and totally horizontal pulse shaper, which significantly simplifies alignment. Second, we demonstrate the applicability of mid-IR focal plane arrays (FPAs) as suitable detectors in 2D IR experiments. FPAs have more pixels than conventional linear arrays and can be used to multiplex optical detection. We simultaneously measure the spectra of a reference beam, which improves the signal-to-noise by a factor of 4; and two additional beams that are orthogonally polarized probe pulses for 2D IR anisotropy experiments. PMID:26907414

Focal Plane Array Shutter Mechanism of the JWST NIRSpec Detector System

NASA Technical Reports Server (NTRS)

Hale, Kathleen; Sharma, Rajeev

2006-01-01

This viewgraph presentation reviews the requirements, chamber location, shutter system design, stepper motor specifications, dry lubrication, control system, the environmental cryogenic function testing and the test results of the Focal Plane Array Shutter mechanism for the James Webb Space Telescope Near Infrared Spectrum Detector system. Included are design views of the location for the Shutter Mechanism, lubricant (lubricated with Molybdenum Di Sulfide) thickness, and information gained from the cryogenic testing.

The Whipple Mission: Design and development of the focal plane

NASA Astrophysics Data System (ADS)

Kenter, A.; Kraft, R.; Murray, S. S.; Gauron, T.; Alcock, C.; Vrtilek, J.

2014-12-01

Whipple is a proposed space borne mission intended to detect and characterize thesize and spatial distribution of Trans Neptunian Objects (TNOs) using the ``blind'' occultation technique. This technique measures the size of, and distance to, a TNO by discerning features of the Fresnel diffraction pattern that is produced when a TNO intercepts the light path between a distant star and the observatory. As the observatory transects the diffraction pattern, it resolves that pattern as a light curve using a differential photometer. The light curve decrement is relatively large (few percent) and the temporal duration is short. For a TNO in the Kuiper Belt the duration is a fraction of a second. For objects in the Oort cloud the duration is ~ a few seconds. Since a blind occultation event is rare, tens of thousands of stars need to be observed simultaneously over several years to accumulate sufficient statistics. Stars need to be observed at cadences up to 40 Hz with a read noise <20e rms (post CDS)Though this is beyond the capability of CCDs, such a high speed, low noise, multi-object differential photometer instrument can be implemented with CMOS imaging technology. The proposed focal plane for the Whipple photometer consists of nine Teledyne HyVISI Silicon hybrid CMOS detectors behind a 77cm F1.34 optic. The detectors consist of 1k by 1k 36 micron pitch pixels and each detector is connected to its own SIDECAR ASIC. Due to the high cadence required, the detectors are operatedin window readout mode. Approximately 700 stars per detector, each in a 2x2 pixel window, will be read out at 40Hz. Progressively more stars can be observed as the cadence decreases, until the limit of the SIDECAR memory is reached at about 4,000 windows The lack of atmospheric turbulence combined with the large field of view and high, speed low noise performance of the focal plane will provide the Whipple mission with unprecedented capability in exploring our Solar System.

Strained-layer superlattice focal plane array having a planar structure

DOEpatents

Kim, Jin K [Albuquerque, NM; Carroll, Malcolm S [Albuquerque, NM; Gin, Aaron [Albuquerque, NM; Marsh, Phillip F [Lowell, MA; Young, Erik W [Albuquerque, NM; Cich, Michael J [Albuquerque, NM

2010-07-13

An infrared focal plane array (FPA) is disclosed which utilizes a strained-layer superlattice (SLS) formed of alternating layers of InAs and In.sub.xGa.sub.1-xSb with 0.ltoreq.x.ltoreq.0.5 epitaxially grown on a GaSb substrate. The FPA avoids the use of a mesa structure to isolate each photodetector element and instead uses impurity-doped regions formed in or about each photodetector for electrical isolation. This results in a substantially-planar structure in which the SLS is unbroken across the entire width of a 2-D array of the photodetector elements which are capped with an epitaxially-grown passivation layer to reduce or eliminate surface recombination. The FPA has applications for use in the wavelength range of 3-25 .mu.m.

Strained layer superlattice focal plane array having a planar structure

DOEpatents

Kim, Jin K; Carroll, Malcolm S; Gin, Aaron; Marsh, Phillip F; Young, Erik W; Cich, Michael J

2012-10-23

An infrared focal plane array (FPA) is disclosed which utilizes a strained-layer superlattice (SLS) formed of alternating layers of InAs and In.sub.xGa.sub.1-xSb with 0.ltoreq.x.ltoreq.0.5 epitaxially grown on a GaSb substrate. The FPA avoids the use of a mesa structure to isolate each photodetector element and instead uses impurity-doped regions formed in or about each photodetector for electrical isolation. This results in a substantially-planar structure in which the SLS is unbroken across the entire width of a 2-D array of the photodetector elements which are capped with an epitaxially-grown passivation layer to reduce or eliminate surface recombination. The FPA has applications for use in the wavelength range of 3-25 .mu.m.

Integrated focal plane arrays for millimeter-wave astronomy

NASA Astrophysics Data System (ADS)

Bock, James J.; Goldin, Alexey; Hunt, Cynthia; Lange, Andrew E.; Leduc, Henry G.; Day, Peter K.; Vayonakis, Anastasios; Zmuidzinas, Jonas

2002-02-01

We are developing focal plane arrays of bolometric detectors for sub-millimeter and millimeter-wave astrophysics. We propose a flexible array architecture using arrays of slot antennae coupled via low-loss superconducting Nb transmission line to microstrip filters and antenna-coupled bolometers. By combining imaging and filtering functions with transmission line, we are able to realize unique structures such as a multi-band polarimeter and a planar, dispersive spectrometer. Micro-strip bolometers have significantly smaller active volume than standard detectors with extended absorbers, and can realize higher sensitivity and speed of response. The integrated array has natural immunity to stray radiation or spectral leaks, and minimizes the suspended mass operating at 0.1-0.3 K. We also discuss future space-borne spectroscopy and polarimetry applications. .

CNES developments of key detection technologies to prepare next generation focal planes for high resolution Earth observation

NASA Astrophysics Data System (ADS)

Materne, A.; Virmontois, C.; Bardoux, A.; Gimenez, T.; Biffi, J. M.; Laubier, D.; Delvit, J. M.

2014-10-01

This paper describes the activities managed by CNES (French National Space Agency) for the development of focal planes for next generation of optical high resolution Earth observation satellites, in low sun-synchronous orbit. CNES has launched a new programme named OTOS, to increase the level of readiness (TRL) of several key technologies for high resolution Earth observation satellites. The OTOS programme includes several actions in the field of detection and focal planes: a new generation of CCD and CMOS image sensors, updated analog front-end electronics and analog-to-digital converters. The main features that must be achieved on focal planes for high resolution Earth Observation, are: readout speed, signal to noise ratio at low light level, anti-blooming efficiency, geometric stability, MTF and line of sight stability. The next steps targeted are presented in comparison to the in-flight measured performance of the PLEIADES satellites launched in 2011 and 2012. The high resolution panchromatic channel is still based upon Backside illuminated (BSI) CCDs operated in Time Delay Integration (TDI). For the multispectral channel, the main evolution consists in moving to TDI mode and the competition is open with the concurrent development of a CCD solution versus a CMOS solution. New CCDs will be based upon several process blocks under evaluation on the e2v 6 inches BSI wafer manufacturing line. The OTOS strategy for CMOS image sensors investigates on one hand custom TDI solutions within a similar approach to CCDs, and, on the other hand, investigates ways to take advantage of existing performance of off-the-shelf 2D arrays CMOS image sensors. We present the characterization results obtained from test vehicles designed for custom TDI operation on several CIS technologies and results obtained before and after radiation on snapshot 2D arrays from the CMOSIS CMV family.

Modulation Transfer Function of Infrared Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Gunapala, S. D.; Rafol, S. B.; Ting, D. Z.; Soibel, A.; Hill, C. J.; Khoshakhlagh, A.; Liu, J. K.; Mumolo, J. M.; Hoglund, L.; Luong, E. M.

2015-01-01

Modulation transfer function (MTF) is the ability of an imaging system to faithfully image a given object. The MTF of an imaging system quantifies the ability of the system to resolve or transfer spatial frequencies. In this presentation we will discuss the detail MTF measurements of 1024x1024 pixels mid -wavelength and long- wavelength quantum well infrared photodetector, and 320x256 pixels long- wavelength InAs/GaSb superlattice infrared focal plane arrays (FPAs). Long wavelength Complementary Barrier Infrared Detector (CBIRD) based on InAs/GaSb superlattice material is hybridized to recently designed and fabricated 320x256 pixel format ROIC. The n-type CBIRD was characterized in terms of performance and thermal stability. The experimentally measured NE delta T of the 8.8 micron cutoff n-CBIRD FPA was 18.6 mK with 300 K background and f/2 cold stop at 78K FPA operating temperature. The horizontal and vertical MTFs of this pixel fully delineated CBIRD FPA at Nyquist frequency are 49% and 52%, respectively.

Smart trigger logic for focal plane arrays

DOEpatents

Levy, James E; Campbell, David V; Holmes, Michael L; Lovejoy, Robert; Wojciechowski, Kenneth; Kay, Randolph R; Cavanaugh, William S; Gurrieri, Thomas M

2014-03-25

An electronic device includes a memory configured to receive data representing light intensity values from pixels in a focal plane array and a processor that analyzes the received data to determine which light values correspond to triggered pixels, where the triggered pixels are those pixels that meet a predefined set of criteria, and determines, for each triggered pixel, a set of neighbor pixels for which light intensity values are to be stored. The electronic device also includes a buffer that temporarily stores light intensity values for at least one previously processed row of pixels, so that when a triggered pixel is identified in a current row, light intensity values for the neighbor pixels in the previously processed row and for the triggered pixel are persistently stored, as well as a data transmitter that transmits the persistently stored light intensity values for the triggered and neighbor pixels to a data receiver.

Third-generation intelligent IR focal plane arrays

NASA Astrophysics Data System (ADS)

Caulfield, H. John; Jack, Michael D.; Pettijohn, Kevin L.; Schlesselmann, John D.; Norworth, Joe

1998-03-01

SBRC is at the forefront of industry in developing IR focal plane arrays including multi-spectral technology and '3rd generation' functions that mimic the human eye. 3rd generation devices conduct advanced processing on or near the FPA that serve to reduce bandwidth while performing needed functions such as automatic target recognition, uniformity correction and dynamic range enhancement. These devices represent a solution for processing the exorbitantly high bandwidth coming off large area FPAs without sacrificing systems sensitivity. SBRC's two-color approach leverages the company's HgCdTe technology to provide simultaneous multiband coverage, from short through long wave IR, with near theoretical performance. IR systems that are sensitive to different spectral bands achieve enhanced capabilities for target identification and advanced discrimination. This paper will provide a summary of the issues, the technology and the benefits of SBRC's third generation smart and two-color FPAs.

Tests of the Monte Carlo simulation of the photon-tagger focal-plane electronics at the MAX IV Laboratory

NASA Astrophysics Data System (ADS)

Preston, M. F.; Myers, L. S.; Annand, J. R. M.; Fissum, K. G.; Hansen, K.; Isaksson, L.; Jebali, R.; Lundin, M.

2014-04-01

Rate-dependent effects in the electronics used to instrument the tagger focal plane at the MAX IV Laboratory were recently investigated using the novel approach of Monte Carlo simulation to allow for normalization of high-rate experimental data acquired with single-hit time-to-digital converters (TDCs). The instrumentation of the tagger focal plane has now been expanded to include multi-hit TDCs. The agreement between results obtained from data taken using single-hit and multi-hit TDCs demonstrate a thorough understanding of the behavior of the detector system.

Solid-state image sensor with focal-plane digital photon-counting pixel array

NASA Technical Reports Server (NTRS)

Fossum, Eric R. (Inventor); Pain, Bedabrata (Inventor)

1995-01-01

A photosensitive layer such as a-Si for a UV/visible wavelength band is provided for low light level imaging with at least a separate CMOS amplifier directly connected to each PIN photodetector diode to provide a focal-plane array of NxN pixels, and preferably a separate photon-counting CMOS circuit directly connected to each CMOS amplifier, although one row of counters may be time shared for reading out the photon flux rate of each diode in the array, together with a buffer memory for storing all rows of the NxN image frame before transfer to suitable storage. All CMOS circuitry is preferably fabricated in the same silicon layer as the PIN photodetector diode for a monolithic structure, but when the wavelength band of interest requires photosensitive material different from silicon, the focal-plane array may be fabricated separately on a different semiconductor layer bump-bonded or otherwise bonded for a virtually monolithic structure with one free terminal of each diode directly connected to the input terminal of its CMOS amplifier and digital counter for integration of the photon flux rate at each photodetector of the array.

Performance of the first HAWAII 4RG-15 arrays in the laboratory and at the telescope

NASA Astrophysics Data System (ADS)

Hall, Donald N. B.; Atkinson, Dani; Beletic, James W.; Blank, Richard; Farris, Mark; Hodapp, Klaus W.; Jacobson, Shane M.; Loose, Markus; Luppino, Gerard

2012-07-01

The primary goal of the HAWAII 4RG-15 (H4RG-15) development is to provide a 16 megapixel 4096x4096 format at significantly reduced price per pixel while maintaining the superb low background performance of the HAWAII 2RG (H2RG). The H4RG-15 design incorporates several new features, notably clocked reference output and interleaved reference pixel readout, that promise to significantly improve noise performance while the reduction in pixel pitch from 18 to 15 microns should improve transimpedance gain although at the expense of some degradation in full well and crosstalk. During the Phase-1 development, Teledyne has produced and screen tested six hybrid arrays. In preparation for Phase-2, the most promising of these are being extensively characterized in the University of Hawaii’s (UH) ULBCam test facility originally developed for the JWST H2RG program. The end-to-end performance of the most promising array has been directly established through astronomical imaging observations at the UH 88-inch telescope on Mauna Kea. We report the performance of these Phase-1 H4RG-15s within the context of established H2RG performance for key parameters (primarily CDS read noise), also highlighting the improvements from the new readout modes.

Fabrication of X-ray Microcalorimeter Focal Planes Composed of Two Distinct Pixel Types

NASA Technical Reports Server (NTRS)

Wassell, Edward J.; Adams, Joseph S.; Bandler, Simon R.; Betancour-Martinez, Gabriele L; Chiao, Meng P.; Chang, Meng Ping; Chervenak, James A.; Datesman, Aaron M.; Eckart, Megan E.; Ewin, Audrey J.;

Stereo Cloud Height and Wind Determination Using Measurements from a Single Focal Plane

NASA Astrophysics Data System (ADS)

Demajistre, R.; Kelly, M. A.

2014-12-01

We present here a method for extracting cloud heights and winds from an aircraft or orbital platform using measurements from a single focal plane, exploiting the motion of the platform to provide multiple views of the cloud tops. To illustrate this method we use data acquired during aircraft flight tests of a set of simple stereo imagers that are well suited to this purpose. Each of these imagers has three linear arrays on the focal plane, one looking forward, one looking aft, and one looking down. Push-broom images from each of these arrays are constructed, and then a spatial correlation analysis is used to deduce the delays and displacements required for wind and cloud height determination. We will present the algorithms necessary for the retrievals, as well as the methods used to determine the uncertainties of the derived cloud heights and winds. We will apply the retrievals and uncertainty determination to a number of image sets acquired by the airborne sensors. We then generalize these results to potential space based observations made by similar types of sensors.

Improved performance of HgCdTe infrared detector focal plane arrays by modulating light field based on photonic crystal structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, Jian; Hu, Weida, E-mail: wdhu@mail.sitp.ac.cn; Ye, Zhenhua

2014-05-14

An HgCdTe long-wavelength infrared focal plane array photodetector is proposed by modulating light distributions based on the photonic crystal. It is shown that a promising prospect of improving performance is better light harvest and dark current limitation. To optimize the photon field distributions of the HgCdTe-based photonic crystal structure, a numerical method is built by combining the finite-element modeling and the finite-difference time-domain simulation. The optical and electrical characteristics of designed HgCdTe mid-wavelength and long-wavelength photon-trapping infrared detector focal plane arrays are obtained numerically. The results indicate that the photon crystal structure, which is entirely compatible with the large infraredmore » focal plane arrays, can significantly reduce the dark current without degrading the quantum efficiency compared to the regular mesa or planar structure.« less

Long-wavelength infrared (LWIR) quantum-dot infrared photodetector (QDIP) focal plane array

NASA Astrophysics Data System (ADS)

Gunapala, S. D.; Bandara, S. V.; Hill, C. J.; Ting, D. Z.; Liu, J. K.; Rafol, S. B.; Blazejewski, E. R.; Mumolo, J. M.; Keo, S. A.; Krishna, S.; Chang, Y. C.; Shott, C. A.

2006-05-01

We have exploited the artificial atomlike properties of epitaxially self-assembled quantum dots for the development of high operating temperature long wavelength infrared (LWIR) focal plane arrays. Quantum dots are nanometer-scale islands that form spontaneously on a semiconductor substrate due to lattice mismatch. QDIPs are expected to outperform quantum well infrared detectors (QWIPs) and are expected to offer significant advantages over II-VI material based focal plane arrays. QDIPs are fabricated using robust wide bandgap III-V materials which are well suited to the production of highly uniform LWIR arrays. We have used molecular beam epitaxy (MBE) technology to grow multi-layer LWIR quantum dot structures based on the InAs/InGaAs/GaAs material system. JPL is building on its significant QWIP experience and is basically building a Dot-in-the-Well (DWELL) device design by embedding InAs quantum dots in a QWIP structure. This hybrid quantum dot/quantum well device offers additional control in wavelength tuning via control of dot-size and/or quantum well sizes. In addition the quantum wells can trap electrons and aide in ground state refilling. Recent measurements have shown a 10 times higher photoconductive gain than the typical QWIP device, which indirectly confirms the lower relaxation rate of excited electrons (photon bottleneck) in QDIPs. Subsequent material and device improvements have demonstrated an absorption quantum efficiency (QE) of ~ 3%. Dot-in-the-well (DWELL) QDIPs were also experimentally shown to absorb both 45o and normally incident light. Thus we have employed a reflection grating structure to further enhance the quantum efficiency. JPL has demonstrated wavelength control by progressively growing material and fabricating devices structures that have continuously increased in LWIR response. The most recent devices exhibit peak responsivity out to 8.1 microns. Peak detectivity of the 8.1μm devices has reached ~ 1 x 1010 Jones at 77 K. Furthermore

Long-Wavelength Infrared (LWIR) Quantum Dot Infrared Photodetector (QDIP) Focal Plane Array

NASA Technical Reports Server (NTRS)

Gunapala, Sarath D.; Bandara, S. V.; Liu, J. K.; Hill, C. J.; Rafol, S. B.; Mumolo, J. M.; Shott, C. A.

2006-01-01

We have exploited the artificial atomlike properties of epitaxially self-assembled quantum dots for the development of high operating temperature long wavelength infrared (LWIR) focal plane arrays. Quantum dots are nanometer-scale islands that form spontaneously on a semiconductor substrate due to lattice mismatch. QDIPs are expected to outperform quantum well infrared detectors (QWIPs) and are expected to offer significant advantages over II-VI material based focal plane arrays. QDIPs are fabricated using robust wide bandgap III-V materials which are well suited to the production of highly uniform LWIR arrays. We have used molecular beam epitaxy (MBE) technology to grow multi-layer LWIR quantum dot structures based on the InAs/InGaAs/GaAs material system. JPL is building on its significant QWIP experience and is basically building a Dot-in-the-Well (DWELL) device design by embedding InAs quantum dots in a QWIP structure. This hybrid quantum dot/quantum well device offers additional control in wavelength tuning via control of dot-size and/or quantum well sizes. In addition the quantum wells can trap electrons and aide in ground state refilling. Recent measurements have shown a 10 times higher photoconductive gain than the typical QWIP device, which indirectly confirms the lower relaxation rate of excited electrons (photon bottleneck) in QDPs. Subsequent material and device improvements have demonstrated an absorption quantum efficiency (QE) of approx. 3%. Dot-in-the-well (DWELL) QDIPs were also experimentally shown to absorb both 45 deg. and normally incident light. Thus we have employed a reflection grating structure to further enhance the quantum efficiency. JPL has demonstrated wavelength control by progressively growing material and fabricating devices structures that have continuously increased in LWIR response. The most recent devices exhibit peak responsivity out to 8.1 microns. Peak detectivity of the 8.1 micrometer devices has reached approx. 1 x 10(exp 10

Planck 2015 results. XII. Full focal plane simulations

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Karakci, A.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Welikala, N.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-09-01

We present the 8th full focal plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18 144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising 104 mission realizations reduced to about 106 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects, and the remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used to validate and verify analysis algorithms and their implementations, and to remove biases from and quantify uncertainties in the results of analyses of the real data.

Occulting focal plane masks for Terrestrial Planet Finder Coronagraph: design, fabrication, simulations and test results

NASA Technical Reports Server (NTRS)

Balasubramanian, Kunjithapatham; Hoppe, Daniel J.; Halverson, Peter G.; Wilson, Daniel W.; Echternach, Pierre M.; Shi, Fang; Lowman, Andrew E.; Niessner, Albert F.; Trauger, John T.; Shaklan, Stuart B.

2005-01-01

Occulting focal plane masks for the Terrestrial Planet Finder Coronagraph (TPF-C) could be designed with continuous gray scale profile of the occulting pattern such as 1-sinc2 on a suitable material or with micron-scale binary transparent and opaque structures of metallic pattern on glass. We have designed, fabricated and tested both kinds of masks. The fundamental characteristics of such masks and initial test results from the High Contrast Imaging Test bed (HCIT) at JPL are presented.

Non-commutative geometry of the h-deformed quantum plane

NASA Astrophysics Data System (ADS)

Cho, S.; Madore, J.; Park, K. S.

1998-03-01

The h-deformed quantum plane is a counterpart of the q-deformed one in the set of quantum planes which are covariant under those quantum deformations of GL(2) which admit a central determinant. We have investigated the non-commutative geometry of the h-deformed quantum plane. There is a two-parameter family of torsion-free linear connections, a one-parameter sub-family of which are compatible with a skew-symmetric non-degenerate bilinear map. The skew-symmetric map resembles a symplectic 2-form and induces a metric. It is also shown that the extended h-deformed quantum plane is a non-commutative version of the Poincaré half-plane, a surface of constant negative Gaussian

Development of the focal plane system for the SEparator for CApture Reactions

NASA Astrophysics Data System (ADS)

Hood, A. A. D.; Blackmon, J. C.; Cottingham, R.; Deibel, C. M.; Good, E.; Joerres, K.; Laminack, A.; Garrity, A.; Secar Collaboration

2017-09-01

The SEparator for CApture Reactions (SECAR) is currently under construction for the National Superconducting Cyclotron Laboratory and future Facility for Rare Isotope Beams. SECAR is designed to conduct sensitive measurements of capture reactions critical to understanding stellar explosions. We have developed a versatile focal plane system that will differentiate reaction recoils from unreacted scattered beam particles in measurements covering a large range of energies and masses. The elements of the focal plane system include two metal-foil, micro-channel plate (MCP) detectors, a variety of diagnostics, and two alternative recoil stopping detectors. The MCP detectors will measure the time-of-flight (and therefore velocity) as well as the position of the recoils. Our primary heavy ion recoil detector is a gas ionization chamber that measures position, total energy and relative energy loss and provides good atomic number discrimination at energies greater than about 0.5 MeV/u. For some cases, this gas counter will be replaced by silicon strip detectors to provide superior energy resolution. We will describe the overall design and report on construction and testing of the detector systems. Supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Awards DE-SC0014384 and DE-FG02-96ER40978.

Planck 2015 results: XII. Full focal plane simulations

DOE PAGES

Ade, P. A. R.; Aghanim, N.; Arnaud, M.; ...

2016-09-20

In this paper, we present the 8th full focal plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18 144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising 10 4 mission realizations reduced to about 10 6 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects, and the remaining subdominant effects will be included in future updates. Finally, generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms,more » FFP8 is used to validate and verify analysis algorithms and their implementations, and to remove biases from and quantify uncertainties in the results of analyses of the real data.« less

Pharmacology of RG W-2938: a cardiotonic agent with vasodilator activity.

PubMed

Barrett, J A; Woltmann, R F; Swillo, R S; Kasiewski, C; Faith, W C; Campbell, H F; Perrone, M H

1990-10-01

The cardiovascular effects of RG W-2938, 6-[6-(3,4-dihydro-3-methyl-2(1H)-2-oxoquinazolinyl)]-4,5-dihydro-3 (2H-pyridazinone, a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent were examined in vivo in anesthetized and conscious dogs and in vitro in isolated guinea pig hearts; in the latter, RG W-2938 5 nmol-5 mumol increased contractility in a dose-related fashion. RG W-2938 30-300 micrograms/kg administered intravenously (i.v.) to anesthetized dogs increased contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) was only slightly increased, and aortic flow was not appreciably altered. A single oral dose of RG W-2938 0.3 mg/kg administered to conscious chronically instrumented dogs produced a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of RG W-2938 30-300 micrograms/kg, i.v. were studied in a mecamylamine-propranolol-induced model of heart failure. RG W-2938 effectively reversed the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR. These studies show that RG W-2938 is an orally effective positive inotropic/vasodilator agent.

Closed-loop focal plane wavefront control with the SCExAO instrument

NASA Astrophysics Data System (ADS)

Martinache, Frantz; Jovanovic, Nemanja; Guyon, Olivier

2016-09-01

Aims: This article describes the implementation of a focal plane based wavefront control loop on the high-contrast imaging instrument SCExAO (Subaru Coronagraphic Extreme Adaptive Optics). The sensor relies on the Fourier analysis of conventional focal-plane images acquired after an asymmetric mask is introduced in the pupil of the instrument. Methods: This absolute sensor is used here in a closed-loop to compensate for the non-common path errors that normally affects any imaging system relying on an upstream adaptive optics system.This specific implementation was used to control low-order modes corresponding to eight zernike modes (from focus to spherical). Results: This loop was successfully run on-sky at the Subaru Telescope and is used to offset the SCExAO deformable mirror shape used as a zero-point by the high-order wavefront sensor. The paper details the range of errors this wavefront-sensing approach can operate within and explores the impact of saturation of the data and how it can be bypassed, at a cost in performance. Conclusions: Beyond this application, because of its low hardware impact, the asymmetric pupil Fourier wavefront sensor (APF-WFS) can easily be ported in a wide variety of wavefront sensing contexts, for ground- as well space-borne telescopes, and for telescope pupils that can be continuous, segmented or even sparse. The technique is powerful because it measures the wavefront where it really matters, at the level of the science detector.

Focal plane based wavefront sensing with random DM probes

NASA Astrophysics Data System (ADS)

Pluzhnik, Eugene; Sirbu, Dan; Belikov, Ruslan; Bendek, Eduardo; Dudinov, Vladimir N.

2017-09-01

An internal coronagraph with an adaptive optical system for wavefront control is being considered for direct imaging of exoplanets with upcoming space missions and concepts, including WFIRST, HabEx, LUVOIR, EXCEDE and ACESat. The main technical challenge associated with direct imaging of exoplanets is to control of both diffracted and scattered light from the star so that even a dim planetary companion can be imaged. For a deformable mirror (DM) to create a dark hole with 10-10 contrast in the image plane, wavefront errors must be accurately measured on the science focal plane detector to ensure a common optical path. We present here a method that uses a set of random phase probes applied to the DM to obtain a high accuracy wavefront estimate even for a dynamically changing optical system. The presented numerical simulations and experimental results show low noise sensitivity, high reliability, and robustness of the proposed approach. The method does not use any additional optics or complex calibration procedures and can be used during the calibration stage of any direct imaging mission. It can also be used in any optical experiment that uses a DM as an active optical element in the layout.

Total variation approach for adaptive nonuniformity correction in focal-plane arrays.

PubMed

Vera, Esteban; Meza, Pablo; Torres, Sergio

2011-01-15

In this Letter we propose an adaptive scene-based nonuniformity correction method for fixed-pattern noise removal in imaging arrays. It is based on the minimization of the total variation of the estimated irradiance, and the resulting function is optimized by an isotropic total variation approach making use of an alternating minimization strategy. The proposed method provides enhanced results when applied to a diverse set of real IR imagery, accurately estimating the nonunifomity parameters of each detector in the focal-plane array at a fast convergence rate, while also forming fewer ghosting artifacts.

Fabrication of X-ray Microcalorimeter Focal Planes Composed of Two Distinct Pixel Types.

PubMed

Wassell, E J; Adams, J S; Bandler, S R; Betancourt-Martinez, G L; Chiao, M P; Chang, M P; Chervenak, J A; Datesman, A M; Eckart, M E; Ewin, A J; Finkbeiner, F M; Ha, J Y; Kelley, R; Kilbourne, C A; Miniussi, A R; Sakai, K; Porter, F; Sadleir, J E; Smith, S J; Wakeham, N A; Yoon, W

2017-06-01

We are developing superconducting transition-edge sensor (TES) microcalorimeter focal planes for versatility in meeting specifications of X-ray imaging spectrometers including high count-rate, high energy resolution, and large field-of-view. In particular, a focal plane composed of two sub-arrays: one of fine-pitch, high count-rate devices and the other of slower, larger pixels with similar energy resolution, offers promise for the next generation of astrophysics instruments, such as the X-ray Integral Field Unit (X-IFU) instrument on the European Space Agency's Athena mission. We have based the sub-arrays of our current design on successful pixel designs that have been demonstrated separately. Pixels with an all gold X-ray absorber on 50 and 75 micron scales where the Mo/Au TES sits atop a thick metal heatsinking layer have shown high resolution and can accommodate high count-rates. The demonstrated larger pixels use a silicon nitride membrane for thermal isolation, thinner Au and an added bismuth layer in a 250 micron square absorber. To tune the parameters of each sub-array requires merging the fabrication processes of the two detector types. We present the fabrication process for dual production of different X-ray absorbers on the same substrate, thick Au on the small pixels and thinner Au with a Bi capping layer on the larger pixels to tune their heat capacities. The process requires multiple electroplating and etching steps, but the absorbers are defined in a single ion milling step. We demonstrate methods for integrating heatsinking of the two types of pixel into the same focal plane consistent with the requirements for each sub-array, including the limiting of thermal crosstalk. We also discuss fabrication process modifications for tuning the intrinsic transition temperature (T c ) of the bilayers for the different device types through variation of the bilayer thicknesses. The latest results on these "hybrid" arrays will be presented.

Fabrication of X-ray Microcalorimeter Focal Planes Composed of Two Distinct Pixel Types

PubMed Central

Wassell, E. J.; Adams, J. S.; Bandler, S. R.; Betancourt-Martinez, G. L.; Chiao, M. P.; Chang, M. P.; Chervenak, J. A.; Datesman, A. M.; Eckart, M. E.; Ewin, A. J.; Finkbeiner, F. M.; Ha, J. Y.; Kelley, R.; Kilbourne, C. A.; Miniussi, A. R.; Sakai, K.; Porter, F.; Sadleir, J. E.; Smith, S. J.; Wakeham, N. A.; Yoon, W.

2017-01-01

We are developing superconducting transition-edge sensor (TES) microcalorimeter focal planes for versatility in meeting specifications of X-ray imaging spectrometers including high count-rate, high energy resolution, and large field-of-view. In particular, a focal plane composed of two sub-arrays: one of fine-pitch, high count-rate devices and the other of slower, larger pixels with similar energy resolution, offers promise for the next generation of astrophysics instruments, such as the X-ray Integral Field Unit (X-IFU) instrument on the European Space Agency’s Athena mission. We have based the sub-arrays of our current design on successful pixel designs that have been demonstrated separately. Pixels with an all gold X-ray absorber on 50 and 75 micron scales where the Mo/Au TES sits atop a thick metal heatsinking layer have shown high resolution and can accommodate high count-rates. The demonstrated larger pixels use a silicon nitride membrane for thermal isolation, thinner Au and an added bismuth layer in a 250 micron square absorber. To tune the parameters of each sub-array requires merging the fabrication processes of the two detector types. We present the fabrication process for dual production of different X-ray absorbers on the same substrate, thick Au on the small pixels and thinner Au with a Bi capping layer on the larger pixels to tune their heat capacities. The process requires multiple electroplating and etching steps, but the absorbers are defined in a single ion milling step. We demonstrate methods for integrating heatsinking of the two types of pixel into the same focal plane consistent with the requirements for each sub-array, including the limiting of thermal crosstalk. We also discuss fabrication process modifications for tuning the intrinsic transition temperature (Tc) of the bilayers for the different device types through variation of the bilayer thicknesses. The latest results on these “hybrid” arrays will be presented. PMID:28804229

High frequency coaxial pulse tube cryocoolers for cooling infrared focal plane arrays

NASA Astrophysics Data System (ADS)

Dang, Haizheng

2010-11-01

A survey is made about the development of high frequency coaxial PTCs. The coolers cover from 30 K to 200 K and the cooling power levels from hundreds of milliwatts to 10's W. Tests suggest that they have the potential to provide appropriate cooling for HgCdTe-based infrared focal plane arrays from near visible down to very long wave infrared region. The paper also discusses the efforts to realize space qualified cryocooler technologies.

Chemical imaging of cotton fibers using an infrared microscope and a focal-plane array detector

USDA-ARS?s Scientific Manuscript database

In this presentation, the chemical imaging of cotton fibers with an infrared microscope and a Focal-Plane Array (FPA) detector will be discussed. Infrared spectroscopy can provide us with information on the structure and quality of cotton fibers. In addition, FPA detectors allow for simultaneous spe...

Light ray field capture using focal plane sweeping and its optical reconstruction using 3D displays.

PubMed

Park, Jae-Hyeung; Lee, Sung-Keun; Jo, Na-Young; Kim, Hee-Jae; Kim, Yong-Soo; Lim, Hong-Gi

2014-10-20

We propose a method to capture light ray field of three-dimensional scene using focal plane sweeping. Multiple images are captured using a usual camera at different focal distances, spanning the three-dimensional scene. The captured images are then back-projected to four-dimensional spatio-angular space to obtain the light ray field. The obtained light ray field can be visualized either using digital processing or optical reconstruction using various three-dimensional display techniques including integral imaging, layered display, and holography.

Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA‑155‑5p inhibition.

PubMed

Wang, Jun; Li, Dan; Hou, Jincai; Lei, Hongtao

2018-02-01

Geniposide, an active component of Gardenia, has been reported to protect against cerebral ischemia in animals. Ginsenoside Rg1, a component of Panax notoginseng, is usually administered in combination with Gardenia for the treatment of acute ischemic stroke; however, there are unknown effects of ginsenoside Rg1 that require further investigation. In the present study, the effects of geniposide and ginsensoide Rg1 combination treatment on focal cerebral ischemic stroke were investigated. For in vivo analysis, male rats were separated into three groups, including the (control), model and geniposide + ginsenoside Rg1 groups (n=8 per group). A middle cerebral artery occlusion model was established as the model group. The treatment group was treated with geniposide (30 mg/kg, tail vein injection) + ginsenoside Rg1 (6 mg/kg, tail vein injection), and the model group received saline instead. Neurobehavioral deficits, infarct volume, brain edema, and the expression of microRNA (miR)‑155‑5p and CD11b by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and immunohistochemistry, were assessed following 24 h of ischemia. For in vitro analysis, BV2 mouse microglial cells were cultured and exposed to geniposide (40 µg/ml) + ginsenoside Rg1 (8 µg/ml) during various durations of oxygen‑glucose deprivation (OGD). The expression levels of miR‑155‑5p, pri‑miR‑155 and pre‑miR‑155 were detected by RT‑qPCR. The results demonstrated that increases in brain infarct volume, edema volume, CD11b‑positive cells and miR‑155‑5p levels were alleviated following geniposide + ginsenoside administration in rats exposed to ischemia. Furthermore, geniposide + ginsenoside Rg1 treatment suppressed the miR‑155‑5p, pri‑miR‑155 and pre‑miR‑155 expression levels in OGD‑injured BV2 microglial cells. The results of the present study demonstrated that tail vein administration of geniposide in combination with ginsenoside Rg1

Corrugated Quantum Well Infrared Photodetector Focal Plane Array Test Results

NASA Technical Reports Server (NTRS)

Goldberg, A.; Choi, K. K.; Das, N. C.; La, A.; Jhabvala, M.

1999-01-01

The corrugated quantum-well infrared photodetector (C-QWIP) uses total internal reflection to couple normal incident light into the optically active quantum wells. The coupling efficiency has been shown to be relatively independent of the pixel size and wavelength thus making the C-QWIP a candidate for detectors over the entire infrared spectrum. The broadband coupling efficiency of the C-QWIP makes it an ideal candidate for multiwavelength detectors. We fabricated and tested C-QWIP focal plane arrays (FPAs) with cutoff wavelengths of 11.2 and 16.2 micrometers. Each FPA has 256 x 256 pixels that are bump-bonded to a direct injection readout circuit. Both FPAs provided infrared imagery with good aesthetic attributes. For the 11.2-micrometers FPA, background-limited performance (BLIP) was observed at 60 K with f/3 optics. For the 16.2-micrometers FPA, BLIP was observed at 38 K. Besides the reduction of dark current in C-QWIP structures, the measured internal quantum efficiency (eta) remains to be high. The values for responsivity and quantum efficiency obtained from the FPA results agree well with those measured for single devices.

A CMOS Imager with Focal Plane Compression using Predictive Coding

NASA Technical Reports Server (NTRS)

Leon-Salas, Walter D.; Balkir, Sina; Sayood, Khalid; Schemm, Nathan; Hoffman, Michael W.

2007-01-01

This paper presents a CMOS image sensor with focal-plane compression. The design has a column-level architecture and it is based on predictive coding techniques for image decorrelation. The prediction operations are performed in the analog domain to avoid quantization noise and to decrease the area complexity of the circuit, The prediction residuals are quantized and encoded by a joint quantizer/coder circuit. To save area resources, the joint quantizerlcoder circuit exploits common circuitry between a single-slope analog-to-digital converter (ADC) and a Golomb-Rice entropy coder. This combination of ADC and encoder allows the integration of the entropy coder at the column level. A prototype chip was fabricated in a 0.35 pm CMOS process. The output of the chip is a compressed bit stream. The test chip occupies a silicon area of 2.60 mm x 5.96 mm which includes an 80 X 44 APS array. Tests of the fabricated chip demonstrate the validity of the design.

MCT-Based LWIR and VLWIR 2D Focal Plane Detector Arrays for Low Dark Current Applications at AIM

NASA Astrophysics Data System (ADS)

Hanna, S.; Eich, D.; Mahlein, K.-M.; Fick, W.; Schirmacher, W.; Thöt, R.; Wendler, J.; Figgemeier, H.

2016-09-01

We present our latest results on n-on- p as well as on p-on- n low dark current planar mercury cadmium telluride (MCT) photodiode technology long wavelength infrared (LWIR) and very long wavelength infrared (VLWIR) two-dimensional focal plane arrays (FPAs) with quantum efficiency (QE) cut-off wavelength >11 μm at 80 K and a 512 × 640 pixel format FPA at 20 μm pitch stitched from two 512 × 320 pixel photodiode arrays. Significantly reduced dark currents as compared with Tennant's "Rule 07" are demonstrated in both polarities while retaining good detection efficiency ≥60% for operating temperatures between 30 K and 100 K. This allows for the same dark current performance at 20 K higher operating temperature than with previous AIM INFRAROT-MODULE GmbH (AIM) technology. For p-on- n LWIR MCT FPAs, broadband photoresponse nonuniformity of only about 1.2% is achieved at 55 K with low defective pixel numbers. For an n-on- p VLWIR MCT FPA with 13.6 μm cut-off at 55 K, excellent photoresponse nonuniformity of about 3.1% is achieved at moderate defective pixel numbers. This advancement in detector technology paves the way for outstanding signal-to-noise ratio performance infrared detection, enabling cutting-edge next-generation LWIR/VLWIR detectors for space instruments and devices with higher operating temperature and low size, weight, and power for field applications.

Focal plane instrument for the Solar UV-Vis-IR Telescope aboard SOLAR-C

NASA Astrophysics Data System (ADS)

Katsukawa, Yukio; Suematsu, Yoshinori; Shimizu, Toshifumi; Ichimoto, Kiyoshi; Takeyama, Norihide

2011-10-01

It is presented the conceptual design of a focal plane instrument for the Solar UV-Vis-IR Telescope (SUVIT) aboard the next Japanese solar mission SOLAR-C. A primary purpose of the telescope is to achieve precise as well as high resolution spectroscopic and polarimetric measurements of the solar chromosphere with a big aperture of 1.5 m, which is expected to make a significant progress in understanding basic MHD processes in the solar atmosphere. The focal plane instrument consists of two packages: A filtergraph package is to get not only monochromatic images but also Dopplergrams and magnetograms using a tunable narrow-band filter and interference filters. A spectrograph package is to perform accurate spectro-polarimetric observations for measuring chromospheric magnetic fields, and is employing a Littrow-type spectrograph. The most challenging aspect in the instrument design is wide wavelength coverage from 280 nm to 1.1 μm to observe multiple chromospheric lines, which is to be realized with a lens unit including fluoride glasses. A high-speed camera for correlation tracking of granular motion is also implemented in one of the packages for an image stabilization system, which is essential to achieve high spatial resolution and high polarimetric accuracy.

Infrared focal plane performance in the South Atlantic anomaly

NASA Technical Reports Server (NTRS)

Junga, Frank A.

1989-01-01

Proton-induced pulse height distributions (PHD's) in Si:XX detectors were studied analytically and experimentally. In addition, a preliminary design for a flight experiment to characterize the response of Si:XX detectors to the trapped proton environment and verify PHD models was developed. PHD's were computed for two orbit altitudes for a variety of shielding configurations. Most of the proton-induced pulses have amplitudes less that about 3.5 x 10(exp 5) e-h pairs. Shielding has a small effect on the shape of the PHD's. The primary effect of shielding is to reduce the total number of pulses produced. Proton-induced PHD's in a Si:Sb focal plane array bombarded by a unidirectional 67-MeV beam were measured. The maximum pulse height recorded was 6 x 10(exp 5) pairs. The distribution had two peaks: the larger peak corresponded to 3.8 x 10(exp 5) pairs and the smaller peak to 1.2 x 10(exp 5) pairs. The maximum pulse height and the larger peak are within a factor of two of predicted values. The low-energy peak was not expected, but is believed to be an artifact of inefficient charge collection in the detector. The planned flight experiment will be conducted on a Space Shuttle flight. Lockheed's helium extended life dewar (HELD) will be used to provide the required cryogenic environment for the detector. Two bulk Si:Sb arrays and two Si:As impurity band conduction arrays will be tested. The tests will be conducted while the Space Shuttle passes through the South Atlantic Anomaly. PHD's will be recorded and responsivity changes tracked. This experiment will provide a new database on proton-induced PHD's, compare two infrared detector technologies in a space environment, and provide the data necessary to validate PHD modeling.

Determining temperature distribution in tissue in the focal plane of the high (>100 W/cm(2)) intensity focused ultrasound beam using phase shift of ultrasound echoes.

PubMed

Karwat, Piotr; Kujawska, Tamara; Lewin, Peter A; Secomski, Wojciech; Gambin, Barbara; Litniewski, Jerzy

2016-02-01

In therapeutic applications of High Intensity Focused Ultrasound (HIFU) the guidance of the HIFU beam and especially its focal plane is of crucial importance. This guidance is needed to appropriately target the focal plane and hence the whole focal volume inside the tumor tissue prior to thermo-ablative treatment and beginning of tissue necrosis. This is currently done using Magnetic Resonance Imaging that is relatively expensive. In this study an ultrasound method, which calculates the variations of speed of sound in the locally heated tissue volume by analyzing the phase shifts of echo-signals received by an ultrasound scanner from this very volume is presented. To improve spatial resolution of B-mode imaging and minimize the uncertainty of temperature estimation the acoustic signals were transmitted and received by 8 MHz linear phased array employing Synthetic Transmit Aperture (STA) technique. Initially, the validity of the algorithm developed was verified experimentally in a tissue-mimicking phantom heated from 20.6 to 48.6 °C. Subsequently, the method was tested using a pork loin sample heated locally by a 2 MHz pulsed HIFU beam with focal intensity ISATA of 129 W/cm(2). The temperature calibration of 2D maps of changes in the sound velocity induced by heating was performed by comparison of the algorithm-determined changes in the sound velocity with the temperatures measured by thermocouples located in the heated tissue volume. The method developed enabled ultrasound temperature imaging of the heated tissue volume from the very inception of heating with the contrast-to-noise ratio of 3.5-12 dB in the temperature range 21-56 °C. Concurrently performed, conventional B-mode imaging revealed CNR close to zero dB until the temperature reached 50 °C causing necrosis. The data presented suggest that the proposed method could offer an alternative to MRI-guided temperature imaging for prediction of the location and extent of the thermal lesion prior to applying the

Read-noise characterization of focal plane array detectors via mean-variance analysis.

PubMed

Sperline, R P; Knight, A K; Gresham, C A; Koppenaal, D W; Hieftje, G M; Denton, M B

2005-11-01

Mean-variance analysis is described as a method for characterization of the read-noise and gain of focal plane array (FPA) detectors, including charge-coupled devices (CCDs), charge-injection devices (CIDs), and complementary metal-oxide-semiconductor (CMOS) multiplexers (infrared arrays). Practical FPA detector characterization is outlined. The nondestructive readout capability available in some CIDs and FPA devices is discussed as a means for signal-to-noise ratio improvement. Derivations of the equations are fully presented to unify understanding of this method by the spectroscopic community.

A Readout Integrated Circuit (ROIC) employing self-adaptive background current compensation technique for Infrared Focal Plane Array (IRFPA)

NASA Astrophysics Data System (ADS)

Zhou, Tong; Zhao, Jian; He, Yong; Jiang, Bo; Su, Yan

2018-05-01

A novel self-adaptive background current compensation circuit applied to infrared focal plane array is proposed in this paper, which can compensate the background current generated in different conditions. Designed double-threshold detection strategy is to estimate and eliminate the background currents, which could significantly reduce the hardware overhead and improve the uniformity among different pixels. In addition, the circuit is well compatible to various categories of infrared thermo-sensitive materials. The testing results of a 4 × 4 experimental chip showed that the proposed circuit achieves high precision, wide application and high intelligence. Tape-out of the 320 × 240 readout circuit, as well as the bonding, encapsulation and imaging verification of uncooled infrared focal plane array, have also been completed.

CdTe focal plane detector for hard x-ray focusing optics

NASA Astrophysics Data System (ADS)

Seller, Paul; Wilson, Matthew D.; Veale, Matthew C.; Schneider, Andreas; Gaskin, Jessica; Wilson-Hodge, Colleen; Christe, Steven; Shih, Albert Y.; Gregory, Kyle; Inglis, Andrew; Panessa, Marco

2015-08-01

The demand for higher resolution x-ray optics (a few arcseconds or better) in the areas of astrophysics and solar science has, in turn, driven the development of complementary detectors. These detectors should have fine pixels, necessary to appropriately oversample the optics at a given focal length, and an energy response also matched to that of the optics. Rutherford Appleton Laboratory have developed a 3-side buttable, 20 mm x 20 mm CdTe-based detector with 250 μm square pixels (80x80 pixels) which achieves 1 keV FWHM @ 60 keV and gives full spectroscopy between 5 keV and 200 keV. An added advantage of these detectors is that they have a full-frame readout rate of 10 kHz. Working with NASA Goddard Space Flight Center and Marshall Space Flight Center, 4 of these 1mm-thick CdTe detectors are tiled into a 2x2 array for use at the focal plane of a balloon-borne hard-x-ray telescope, and a similar configuration could be suitable for astrophysics and solar space-based missions. This effort encompasses the fabrication and testing of flightsuitable front-end electronics and calibration of the assembled detector arrays. We explain the operation of the pixelated ASIC readout and measurements, front-end electronics development, preliminary X-ray imaging and spectral performance, and plans for full calibration of the detector assemblies. Work done in conjunction with the NASA Centers is funded through the NASA Science Mission Directorate Astrophysics Research and Analysis Program.

CdTe Focal Plane Detector for Hard X-Ray Focusing Optics

NASA Technical Reports Server (NTRS)

Seller, Paul; Wilson, Matthew D.; Veale, Matthew C.; Schneider, Andreas; Gaskin, Jessica; Wilson-Hodge, Colleen; Christe, Steven; Shih, Albert Y.; Inglis, Andrew; Panessa, Marco

2015-01-01

The demand for higher resolution x-ray optics (a few arcseconds or better) in the areas of astrophysics and solar science has, in turn, driven the development of complementary detectors. These detectors should have fine pixels, necessary to appropriately oversample the optics at a given focal length, and an energy response also matched to that of the optics. Rutherford Appleton Laboratory have developed a 3-side buttable, 20 millimeter x 20 millimeter CdTe-based detector with 250 micrometer square pixels (80 x 80 pixels) which achieves 1 kiloelectronvolt FWHM (Full-Width Half-Maximum) @ 60 kiloelectronvolts and gives full spectroscopy between 5 kiloelectronvolts and 200 kiloelectronvolts. An added advantage of these detectors is that they have a full-frame readout rate of 10 kilohertz. Working with NASA Goddard Space Flight Center and Marshall Space Flight Center, 4 of these 1 millimeter-thick CdTe detectors are tiled into a 2 x 2 array for use at the focal plane of a balloon-borne hard-x-ray telescope, and a similar configuration could be suitable for astrophysics and solar space-based missions. This effort encompasses the fabrication and testing of flight-suitable front-end electronics and calibration of the assembled detector arrays. We explain the operation of the pixelated ASIC readout and measurements, front-end electronics development, preliminary X-ray imaging and spectral performance, and plans for full calibration of the detector assemblies. Work done in conjunction with the NASA Centers is funded through the NASA Science Mission Directorate Astrophysics Research and Analysis Program.

Identification and classification of chemicals using terahertz reflective spectroscopic focal-plane imaging system.

PubMed

Zhong, Hua; Redo-Sanchez, Albert; Zhang, X-C

2006-10-02

We present terahertz (THz) reflective spectroscopic focal-plane imaging of four explosive and bio-chemical materials (2, 4-DNT, Theophylline, RDX and Glutamic Acid) at a standoff imaging distance of 0.4 m. The 2 dimension (2-D) nature of this technique enables a fast acquisition time and is very close to a camera-like operation, compared to the most commonly used point emission-detection and raster scanning configuration. The samples are identified by their absorption peaks extracted from the negative derivative of the reflection coefficient respect to the frequency (-dr/dv) of each pixel. Classification of the samples is achieved by using minimum distance classifier and neural network methods with a rate of accuracy above 80% and a false alarm rate below 8%. This result supports the future application of THz time-domain spectroscopy (TDS) in standoff distance sensing, imaging, and identification.

Terahertz detectors and focal plane arrays

NASA Astrophysics Data System (ADS)

Rogalski, A.; Sizov, F.

2011-09-01

Terahertz (THz) technology is one of emerging technologies that will change our life. A lot of attractive applications in security, medicine, biology, astronomy, and non-destructive materials testing have been demonstrated already. However, the realization of THz emitters and receivers is a challenge because the frequencies are too high for conventional electronics and the photon energies are too small for classical optics. As a result, THz radiation is resistant to the techniques commonly employed in these well established neighbouring bands. In the paper, issues associated with the development and exploitation of THz radiation detectors and focal plane arrays are discussed. Historical impressive progress in THz detector sensitivity in a period of more than half century is analyzed. More attention is put on the basic physical phenomena and the recent progress in both direct and heterodyne detectors. After short description of general classification of THz detectors, more details concern Schottky barrier diodes, pair braking detectors, hot electron mixers and field-effect transistor detectors, where links between THz devices and modern technologies such as micromachining are underlined. Also, the operational conditions of THz detectors and their upper performance limits are reviewed. Finally, recent advances in novel nanoelectronic materials and technologies are described. It is expected that applications of nanoscale materials and devices will open the door for further performance improvement in THz detectors.

Focal plane mechanical design of the NISP/Euclid instrument

NASA Astrophysics Data System (ADS)

Bonnefoi, Anne; Bon, William; Niclas, Mathieu; Solheim, Bjarte G. B.; Torvanger, Oyvind; Schistad, Robert; Foulon, Benjamin; Garcia, José; Vives, Sébastien

2016-07-01

Currently in phase C, the Euclid mission selected by ESA in the Cosmic Vision program is dedicated to understand dark energy and dark matter. NISP (standing for Near Infrared Spectro-Photometer) is one of the two instruments of the mission. NISP will combine a photometer and a spectrometer working in the near-IR (0.9-2 microns). Its detection subsystem (called NI-DS) is based on a mosaic of 16 IR detectors cooled down to 90K which are supported by a molybdenum plate. The front-end readout electronics (working at 130K) are supported by another structure in Aluminum. The NI-DS is mounted on the rest of the instrument thanks to a panel in Silicon Carbide (SiC). Finally an optical baffle in Titanium will prevent the rogue light to reach the detectors. On top of the complexity due to the wide range of temperatures and the various materials imposed at the interfaces; the NI-DS has also to incorporate an internal adjustment capability of the position of the focal plane in tip/tilt and focus. This article will present current status of the development of the detection system of NISP.

Back focal plane microscopic ellipsometer with internal reflection geometry

NASA Astrophysics Data System (ADS)

Otsuki, Soichi; Murase, Norio; Kano, Hiroshi

2013-05-01

A back focal plane (BFP) ellipsometer is presented to measure a thin film on a cover glass using an oil-immersion high-numerical-aperture objective lens. The internal reflection geometry lowers the pseudo Brewster angle (ϕB) to the range over which the light distribution is observed in BFP of the objective. A calculation based on Mueller matrix was developed to compute ellipsometric parameters from the intensity distribution on BFP. The center and radius of the partial reflection region below the critical angle were determined and used to define a polar coordinate on BFP. Harmonic components were computed from the intensities along the azimuth direction and transformed to ellipsometric parameters at multiple incident angles around ϕB. The refractive index and thickness of the film and the contributions of the objective effect were estimated at the same time by fitting.

A junction-level optoelectronic characterization of etching-induced damage for third-generation HgCdTe infrared focal-plane array photodetectors

NASA Astrophysics Data System (ADS)

Wang, Peng; Wang, Yueming; Wu, Mingzai; Ye, Zhenhua

2018-06-01

Third-generation HgCdTe-based infrared focal plane arrays require high aspect ratio trenches with admissible etch induced damage at the surface and sidewalls for effectively isolating the pixels. In this paper, the high-density inductively coupled plasma enhanced reaction ion etching technique has been used for micro-mesa delineation of HgCdTe for third-generation infrared focal-plane array detectors. A nondestructive junction-level optoelectronic characterization method called laser beam induced current (LBIC) is used to evaluate the lateral junction extent of HgCdTe etch-induced damage scanning electron microscopy. It is found that the LBIC profiles exhibit evident double peaks and valleys phenomena. The lateral extent of etch induced mesa damage of ∼2.4 μm is obtained by comparing the LBIC profile and the scanning electron microscopy image of etched sample. This finding will guide us to nondestructively identify the distributions of the etching damages in large scale HgCdTe micro-mesa.

InGaAs focal plane arrays for low-light-level SWIR imaging

NASA Astrophysics Data System (ADS)

MacDougal, Michael; Hood, Andrew; Geske, Jon; Wang, Jim; Patel, Falgun; Follman, David; Manzo, Juan; Getty, Jonathan

2011-06-01

Aerius Photonics will present their latest developments in large InGaAs focal plane arrays, which are used for low light level imaging in the short wavelength infrared (SWIR) regime. Aerius will present imaging in both 1280x1024 and 640x512 formats. Aerius will present characterization of the FPA including dark current measurements. Aerius will also show the results of development of SWIR FPAs for high temperaures, including imagery and dark current data. Finally, Aerius will show results of using the SWIR camera with Aerius' SWIR illuminators using VCSEL technology.

Life test of the InGaAs focal plane arrays detector for space applications

NASA Astrophysics Data System (ADS)

Zhu, Xian-Liang; Zhang, Hai-Yan; Li, Xue; Huang, Zhang-Cheng; Gong, Hai-Mei

2017-08-01

The short-wavelength infrared (SWIR) InGaAs focal plane array (FPA) detector consists of infrared detector chip, readout integrated circuit (ROIC), and flip-chip bonding interconnection by Indium bump. In order to satisfy space application requirements for failure rates or Mean Time to Failure (MTTF), which can only be demonstrated with the large number of detectors manufactured, the single pixel in InGaAs FPAs was chosen as the research object in this paper. The constant-stress accelerated life tests were carried out at 70°C 80°C 90°C and100°C. The failed pixels increased gradually during more than 14000 hours at each elevated temperatures. From the random failure data the activation energy was estimated to be 0.46eV, and the average lifetime of a single pixel in InGaAs FPAs was estimated to be longer than 1E+7h at the practical operating temperature (5°C).

Paraxial design of an optical element with variable focal length and fixed position of principal planes.

PubMed

Mikš, Antonín; Novák, Pavel

2018-05-10

In this article, we analyze the problem of the paraxial design of an active optical element with variable focal length, which maintains the positions of its principal planes fixed during the change of its optical power. Such optical elements are important in the process of design of complex optical systems (e.g., zoom systems), where the fixed position of principal planes during the change of optical power is essential for the design process. The proposed solution is based on the generalized membrane tunable-focus fluidic lens with several membrane surfaces.

Impact of a potential glycosylation site at neuraminidase amino acid 264 of influenza A/H9N2 virus.

PubMed

Shao, Hongxia; Zhou, Xiaoxiang; Fan, Zhonglei; Wan, Zhimin; Qian, Kun; Perez, Daniel; Qin, Aijian; Ye, Jianqiang

2016-11-30

To determine the role of the potential glycosylation site NA264N, which has been shown to be prevalent in recent Chinese H9N2 isolates, four reverse genetic viruses, rgWS1-NA264N, rgWS1-NA264H, rgBJ-NA264H and rgBJ-NA264N, were rescued. Growth kinetics showed that viruses with NA264H grew faster than viruses with NA264N. Mouse studies revealed that rgBJ-NA264H replicated to a significantly higher titer than rgBJ-NA264N at 3dpi. Notably, in contact chickens, rgBJ-NA264H and rgWS1-NA264H shed significantly more virus than rgBJ-NA264N at 6dpi from the larynx and rgWS1-NA264N at 4dpi from the cloaca, respectively. The present study demonstrates that NA264N affects viral replication of H9N2. Copyright © 2016 Elsevier B.V. All rights reserved.

New γ -radiation screening procedures of infrared focal plane arrays (IR FPA)

NASA Astrophysics Data System (ADS)

Chen, Hong-lei; Hao, Lichao; Huang, Ai-Bo; Lin, Jiamu; Zhang, Jun-ling; Feng, Qi; Ding, Rui-jun

2013-01-01

Infrared focal plane HgCdTe device is used in the environment of complicated astrospace radiation. To achieve the instrument's actual service life, the anti-radiation ability is needed to study in our research. The irradiation-induced invalidation mechanism of semiconductor materials is introduced in this paper, and the screening experiments' total radiation dose of American Military Standard is also investigated in our study. Through the simulation of astrospace radiation effect by γ -irradiation, the experimental procedures are proved to be rational by the analysis of the experimental data. With the domestic conditions, radiation screening procedures which meets the practical need is suggested.

Detectors and Focal Plane Modules for Weather Satellites

NASA Technical Reports Server (NTRS)

D'Souza, A. I.; Robinson, E.; Masterjohn, S.; Ely, P.; Khalap, V.; Babu, S.; Smith, D. S.

2016-01-01

Weather satellite instruments require detectors with a variety of wavelengths ranging from the visible to VLWIR. One of the remote sensing applications is the geostationary GOES-ABI imager covering wavelengths from the 450 to 490 nm band through the 13.0 to 13.6 micron band. There are a total of 16 spectral bands covered. The Cross-track infrared Sounder (CrIS) is a Polar Orbiting interferometric sensor that measures earth radiances at high spectral resolution, using the data to provide pressure, temperature and moisture profiles of the atmosphere. The pressure, temperature and moisture sounding data are used in weather prediction models that track storms, predict levels of precipitation etc. The CrIS instrument contains SWIR (lamba(sub c) approximately 5 micron at 98K), MWIR (lambda(sub c) approximately 9 micron at 98K) and LWIRs (lamba(sub c) approximately 15.5 micron at 81K) bands in three Focal Plane Array Assemblies (FPAAs). GOES-ABI contains three focal plane modules (FPMs), (i) a visible-near infrared module consisting of three visible and three near infrared channels, (ii) a MWIR module comprised of five channels from 3.9 micron to 8.6 micron and (iii) a 9.6 micron to 13.3 micron, five-channel LWIR module. The VNIR FPM operates at 205 K, and the MWIR and LWIR FPMs operate at 60 K. Each spectral channel has a redundant array built into a single detector chip. Switching is thus permitted from the primary selected array in each channel to the redundant array, given any degradation in performance of the primary array during the course of the mission. Silicon p-i-n detectors are used for the 0.47 micron to 0.86 micron channels. The thirteen channels above 1 micron are fabricated in various compositions of Hg1-xCdxTe, and in this particular case using two different detector architectures. The 1.38 micron to 9.61 micron channels are all fabricated in Hg1-xCdxTe grown by Liquid Phase Epitaxy (LPE) using the HDVIP detector architecture. Molecular beam epitaxy (MBE

Detectors and focal plane modules for weather satellites

NASA Astrophysics Data System (ADS)

D'Souza, A. I.; Robinson, E.; Masterjohn, S.; Ely, P.; Khalap, V.; Babu, S.; Smith, D. S.

2016-05-01

Weather satellite instruments require detectors with a variety of wavelengths ranging from the visible to VLWIR. One of the remote sensing applications is the geostationary GOES-ABI imager covering wavelengths from the 450 to 490 nm band through the 13.0 to 13.6 μm band. There are a total of 16 spectral bands covered. The Cross-track infrared Sounder (CrIS) is a Polar Orbiting interferometric sensor that measures earth radiances at high spectral resolution, using the data to provide pressure, temperature and moisture profiles of the atmosphere. The pressure, temperature and moisture sounding data are used in weather prediction models that track storms, predict levels of precipitation etc. The CrIS instrument contains SWIR (λc ~ 5 μm at 98K), MWIR (λc ~ 9 μm at 98K) and LWIRs (λc ~ 15.5 μm at 81K) bands in three Focal Plane Array Assemblies (FPAAs). GOES-ABI contains three focal plane modules (FPMs), (i) a visible-near infrared module consisting of three visible and three near infrared channels, (ii) a MWIR module comprised of five channels from 3.9 μm to 8.6 μm and (iii) a 9.6 μm to 13.3 μm, five-channel LWIR module. The VNIR FPM operates at 205 K, and the MWIR and LWIR FPMs operate at 60 K. Each spectral channel has a redundant array built into a single detector chip. Switching is thus permitted from the primary selected array in each channel to the redundant array, given any degradation in performance of the primary array during the course of the mission. Silicon p-i-n detectors are used for the 0.47 μm to 0.86 μm channels. The thirteen channels above 1 μm are fabricated in various compositions of Hg1-xCdxTe, and in this particular case using two different detector architectures. The 1.38 μm to 9.61 μm channels are all fabricated in Hg1-xCdxTe grown by Liquid Phase Epitaxy (LPE) using the HDVIP detector architecture. Molecular beam epitaxy (MBE)-grown Hg1-xCdxTe material are used for the LWIR 10.35 μm to 13.3 μm channels fabricated in Double

Examination of cotton fibers and common contaminants using an infrared microscope and a focal-plane array detector

USDA-ARS?s Scientific Manuscript database

The chemical imaging of cotton fibers and common contaminants in fibers is presented. Chemical imaging was performed with an infrared microscope equipped with a Focal-Plane Array (FPA) detector. Infrared spectroscopy can provide us with information on the structure and quality of cotton fibers. In a...

The University of Florida's next-generation cryogenic infrared focal plane array controller system

NASA Astrophysics Data System (ADS)

Raines, Steven N.; Boreman, Glenn D.; Eikenberry, Stephen S.; Bandyopadhyay, Reba M.; Quijano, Ismael

2008-07-01

The Infrared Instrumentation Group at the University of Florida has substantial experience building IR focal plane array (FPA) controllers and seamlessly integrating them into the instruments that it builds for 8-meter class observatories, including writing device drivers for UNIX-based computer systems. We report on a design study to investigate implementing an ASIC from Teledyne Imaging Systems (TIS) into our IR FPA controller while simultaneously replacing TIS's interface card with one that eliminates the requirement for a Windows-OS computer within the instrument's control system.

MultiFocus Polarization Microscope (MF-PolScope) for 3D polarization imaging of up to 25 focal planes simultaneously

PubMed Central

Abrahamsson, Sara; McQuilken, Molly; Mehta, Shalin B.; Verma, Amitabh; Larsch, Johannes; Ilic, Rob; Heintzmann, Rainer; Bargmann, Cornelia I.; Gladfelter, Amy S.; Oldenbourg, Rudolf

2015-01-01

We have developed an imaging system for 3D time-lapse polarization microscopy of living biological samples. Polarization imaging reveals the position, alignment and orientation of submicroscopic features in label-free as well as fluorescently labeled specimens. Optical anisotropies are calculated from a series of images where the sample is illuminated by light of different polarization states. Due to the number of images necessary to collect both multiple polarization states and multiple focal planes, 3D polarization imaging is most often prohibitively slow. Our MF-PolScope system employs multifocus optics to form an instantaneous 3D image of up to 25 simultaneous focal-planes. We describe this optical system and show examples of 3D multi-focus polarization imaging of biological samples, including a protein assembly study in budding yeast cells. PMID:25837112

Mercury-Cadmium-Telluride Focal Plane Array Performance Under Non-Standard Operating Conditions

NASA Technical Reports Server (NTRS)

Richardson, Brandon S.; Eastwood, Michael L.; Bruce, Carl F.; Green, Robert O.; Coles, J. B.

2011-01-01

This paper highlights a new technique that allows the Teledyne Scientific & Imaging LLC TCM6604A Mercury-Cadmium-Telluride (MCT) Focal Plane Array (FPA) to operate at room temperature. The Teledyne MCT FPA has been a standard in Imaging Spectroscopy since its creation in the 1980's. This FPA has been used in applications ranging from space instruments such as CRISM, M3 and ARTEMIS to airborne instruments such as MaRS and the Next Generation AVIRIS Instruments1. Precise focal plane alignment is always a challenge for such instruments. The current FPA alignment process results in multiple cold cycles requiring week-long durations, thereby increasing the risk and cost of a project. These alignment cycles are necessary because optimal alignment is approached incrementally and can only be measured with the FPA and Optics at standard operating conditions, requiring a cold instrument. Instruments using this FPA are normally cooled to temperatures below 150K for the MCT FPA to properly function. When the FPA is run at higher temperatures the dark current increases saturating the output. This paper covers the prospect of warm MCT FPA operation from a theoretical and experimental perspective. We discuss the empirical models and physical laws that govern MCT material properties and predict the optimal settings that will result in the best MCT PA performance at 300K. Theoretical results are then calculated for the proposed settings. We finally present the images and data obtained using the actual system with the warm MCT FPA settings. The paper concludes by emphasizing the strong positive correlation between the measured values and the theoretical results.

Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway.

PubMed

Hu, Junzheng; Gu, Yanqing; Fan, Weimin

2016-07-01

The aim of the present study was to investigate the protective mechanism of ginsenoside Rg1 against the apoptosis of rat bone marrow stem cells (rBMSCs) under oxidative stress, and to determine the association with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. H2O2 was used to induce oxidative injury in rBMSCs. The cells in the H2O2 model group were treated with 800 µM H2O2 for 6 h to induce oxidative injury. The cells in the ginsenoside Rg1 group were treated with 10 µM ginsenoside Rg1 for 24 h, followed by H2O2 treatment. The cells in the Akt pathway blockage group were treated with 25 µM LY294002 for 1 h, followed by ginsenoside Rg1 + H2O2 treatment. The cell counting kit-8 assay was performed to determine cell viability. Cell apoptosis was detected by flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. The results of flow cytometry and TUNEL staining indicated that the apoptotic rate of the H2O2 model group was significantly higher compared with that of the control group. Following the ginsenoside Rg1 pretreatment, the apoptotic rate was significantly reduced. In the Akt pathway blockage group, no significant alterations in the levels of cell apoptosis were observed compared with the H2O2 model group. Western blot analysis demonstrated that the ginsenoside Rg1 group had a significant downregulation of Bax and cleaved caspase‑3 and an upregulation of Bcl‑2 and phosphorylated Akt protein expression levels compared with the H2O2 model group and the Akt pathway blockage group. In conclusion, ginsenoside Rg1 had a protective effect against the H2O2‑induced oxidative stress of rBMSCs, and the specific mechanism may be associated with the activation of the PI3K/Akt pathway by ginsenoside Rg1.

Blocked impurity band hybrid infrared focal plane arrays for astronomy

NASA Technical Reports Server (NTRS)

Reynolds, D. B.; Seib, D. H.; Stetson, S. B.; Herter, T.; Rowlands, N.

1989-01-01

High-performance infrared hybrid focal plane arrays using 10- x 50-element Si:As blocked-impurity-band (BIB) detectors (cutoff wavelength = 28 microns) and matching switched MOSFET multiplexers have been developed and characterized for space astronomy. Use of impurity-band-conduction technology provides detectors which are nuclear-radiation-hard and free of the many anomalies associated with conventional silicon photoconductive detectors. Emphasis in the present work is on recent advances in detector material quality which have led to significantly improved detector and hybrid characteristics. Results demonstrating increased quantum efficiency (particularly at short-wavelength infrared), obtained by varying the BIB detector properties (infrared active layer thickness and arsenic doping profile), are summarized. Measured read noise and dark current for different temperatures are reported. The hybrid array performance achieved demonstrates that BIB detectors are well suited for use in astronomical instrumentation.

The Advanced Gamma-ray Imaging System (AGIS): Focal Plane Detectors

NASA Astrophysics Data System (ADS)

Mukherjee, Reshmi; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Horan, D.; Tajima, H.; Wagner, B.; Williams, D.

2008-04-01

Report of the Focal Plane Instrumentation Working Group, AGIS collaboration: The Advanced Gamma-ray Imaging System (AGIS) is a concept for the next generation instrument in ground-based very high energy gamma-ray astronomy. It has the goal of achieving significant improvement in sensitivity over current experiments. One of the main requirements for AGIS will be to achieve higher angular resolution than current imaging atmospheric Cherenkov telescopes (IACTs). Simulations show that a substantial improvement in angular resolution may be achieved if the pixel size is reduced to 0.05 deg, below that of current IACTs. Reducing the cost per channel and improving reliability and modularity are other important considerations. Here we present several alternatives being considered for AGIS, including both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs) and summarize results from feasibility testing by various AGIS photodetector group members.

THE DYNACELL AND FOCAL PLANE CONCEPTS OF PHOTOTROPIC SYSTEMS APPLICATION TO OPHTHALMIC NUCLEAR FLASH-PROTECTIVE DEVICES

DTIC Science & Technology

Two concepts of phototropic systems application are presented in this report. These concepts, when considered individually or in combination, make...possible the development of improved, directly or indirectly actuated, phototropic , ophthalmic, nuclear flash-protective devices. By the application...of a phototropic filter at the focal plane of an optical system, the attenuation of the phototropic response due to distance is minimized. Using a

Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats

PubMed Central

Deng, Yanping; Yang, Min; Xu, Feng; Zhang, Qian; Zhao, Qun; Yu, Haitao; Li, Defang; Zhang, Ge; Lu, Aiping; Cho, Kenka; Teng, Fukang; Wu, Peng; Wang, Linlin; Wu, Wanying; Liu, Xuan; Guo, De-an; Jiang, Baohong

2015-01-01

Lack of pharmacological strategies in clinics restricts the patient prognosis with myocardial ischemia/reperfusion (I/R) injury. The aim of this study was to evaluate the cardioprotection of combined salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) against myocardial I/R injury and further investigate the underlying mechanism. I/R injury was induced by coronary artery ligation for Wistar male rats and hypoxia/reoxygenation injury was induced on H9c2 cells. Firstly, the best ratio between SalB and Rg1was set as 2:5 based on their effects on heart function detected by hemodynamic measurement. Then SalB-Rg1 (2:5) was found to maintain mitochondrial membrane potential and resist apoptosis and necrosis in H9c2 cell with hypoxia/reoxygenation injury. Companying with same dose of SalB or Rg1 only, SalB-Rg1 showed more significant effects on down-regulation of myocardial infarct size, maintenance of myocardium structure, improvement on cardiac function, decrease of cytokine secretion including TNF-α, IL-1β, RANTES and sVCAM-1. Finally, the SalB-Rg1 improved the viability of cardiac myocytes other than cardiac fibroblasts in rats with I/R injury using flow cytometry. Our results revealed that SalB-Rg1 was a promising strategy to prevent myocardial I/R injury. PMID:26280455

The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

PubMed Central

Gum, Sang Il; Cho, Min Kyung

2013-01-01

Previously, we found that Korean red ginseng suppressed acetaminophen (APAP)-induced hepatotoxicity via alteration of its metabolic profile involving GSTA2 induction and that ginsenoside Rg3 was a major component of this gene induction. In the present study, therefore, we assessed the protective effect of Rg3 against N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolic intermediate of APAP. Excess NAPQI resulted in GSH depletion with increases in the ALT and AST activities in H4IIE cells. Rg3 pretreatment reversed GSH depletion by NAPQI. Rg3 resulted in increased mRNA levels of the catalytic and modulatory subunit of glutamate cysteine ligase (GCL), the rate-limiting steps in GSH synthesis and subsequently increased GSH content. Rg3 increased levels of nuclear Nrf2, an essential transcriptional factor of these genes. The knockdown or knockout of the Nrf2 gene abrogated the inductions of mRNA and protein by Rg3. Abolishment of the reversal of GSH depletion by Rg3 against NAPQI was observed in Nrf2-deficient cells. Rg3 induced multidrug resistance-associated protein (Mrp) 1 and Mrp3 mRNA levels, but not in Nrf2-deficient cells. Taken together, these results demonstrate that Rg3 is efficacious in protecting hepatocytes against NAPQI insult, due to GSH repletion and coordinated gene regulations of GSH synthesis and Mrp family genes by Nrf2. PMID:23766864

Performance enhancement of uncooled infrared focal plane array by integrating metamaterial absorber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Wei; Wen, Yongzheng; Yu, Xiaomei, E-mail: yuxm@pku.edu.cn

2015-03-16

This letter presents an infrared (IR) focal plane array (FPA) with metamaterial absorber (MMA) integrated to enhance its performance. A glass substrate, on which arrays of bimaterial cantilevers are fabricated as the thermal-sensitive pixels by a polyimide surface sacrificial process, is employed to allow the optical readout from the back side of the substrate. Whereas the IR wave radiates onto the FPA from the front side, which consequently avoids the energy loss caused by the silicon substrate compared with the previous works. This structure also facilitates the integration of MMA by introducing a layer of periodic square resonators atop themore » SiN{sub x} structural layer to form a metal/dielectric/metal stack with the gold mirror functioning as the ground plane. A comparative experiment was carried out on the FPAs that use MMA and ordinary SiN{sub x} as the absorbers, respectively. The performance improvement was verified by the evaluation of the absorbers as well as the imaging results of both FPAs.« less

Quantum Well and Quantum Dot Modeling for Advanced Infrared Detectors and Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Ting, David; Gunapala, S. D.; Bandara, S. V.; Hill, C. J.

2006-01-01

This viewgraph presentation reviews the modeling of Quantum Well Infrared Detectors (QWIP) and Quantum Dot Infrared Detectors (QDIP) in the development of Focal Plane Arrays (FPA). The QWIP Detector being developed is a dual band detector. It is capable of running on two bands Long-Wave Infrared (LWIR) and Medium Wavelength Infrared (MWIR). The same large-format dual-band FPA technology can be applied to Quantum Dot Infrared Photodetector (QDIP) with no modification, once QDIP exceeds QWIP in single device performance. Details of the devices are reviewed.

Angular acceptance analysis of an infrared focal plane array with a built-in stationary Fourier transform spectrometer.

PubMed

Gillard, Frédéric; Ferrec, Yann; Guérineau, Nicolas; Rommeluère, Sylvain; Taboury, Jean; Chavel, Pierre

2012-06-01

Stationary Fourier transform spectrometry is an interesting concept for building reliable field or embedded spectroradiometers, especially for the mid- and far- IR. Here, a very compact configuration of a cryogenic stationary Fourier transform IR (FTIR) spectrometer is investigated, where the interferometer is directly integrated in the focal plane array (FPA). We present a theoretical analysis to explain and describe the fringe formation inside the FTIR-FPA structure when illuminated by an extended source positioned at a finite distance from the detection plane. The results are then exploited to propose a simple front lens design compatible with a handheld package.

An algebraic algorithm for nonuniformity correction in focal-plane arrays.

PubMed

Ratliff, Bradley M; Hayat, Majeed M; Hardie, Russell C

2002-09-01

A scene-based algorithm is developed to compensate for bias nonuniformity in focal-plane arrays. Nonuniformity can be extremely problematic, especially for mid- to far-infrared imaging systems. The technique is based on use of estimates of interframe subpixel shifts in an image sequence, in conjunction with a linear-interpolation model for the motion, to extract information on the bias nonuniformity algebraically. The performance of the proposed algorithm is analyzed by using real infrared and simulated data. One advantage of this technique is its simplicity; it requires relatively few frames to generate an effective correction matrix, thereby permitting the execution of frequent on-the-fly nonuniformity correction as drift occurs. Additionally, the performance is shown to exhibit considerable robustness with respect to lack of the common types of temporal and spatial irradiance diversity that are typically required by statistical scene-based nonuniformity correction techniques.

Robust Approach for Nonuniformity Correction in Infrared Focal Plane Array.

PubMed

Boutemedjet, Ayoub; Deng, Chenwei; Zhao, Baojun

2016-11-10

In this paper, we propose a new scene-based nonuniformity correction technique for infrared focal plane arrays. Our work is based on the use of two well-known scene-based methods, namely, adaptive and interframe registration-based exploiting pure translation motion model between frames. The two approaches have their benefits and drawbacks, which make them extremely effective in certain conditions and not adapted for others. Following on that, we developed a method robust to various conditions, which may slow or affect the correction process by elaborating a decision criterion that adapts the process to the most effective technique to ensure fast and reliable correction. In addition to that, problems such as bad pixels and ghosting artifacts are also dealt with to enhance the overall quality of the correction. The performance of the proposed technique is investigated and compared to the two state-of-the-art techniques cited above.

Robust Approach for Nonuniformity Correction in Infrared Focal Plane Array

PubMed Central

Boutemedjet, Ayoub; Deng, Chenwei; Zhao, Baojun

2016-01-01

In this paper, we propose a new scene-based nonuniformity correction technique for infrared focal plane arrays. Our work is based on the use of two well-known scene-based methods, namely, adaptive and interframe registration-based exploiting pure translation motion model between frames. The two approaches have their benefits and drawbacks, which make them extremely effective in certain conditions and not adapted for others. Following on that, we developed a method robust to various conditions, which may slow or affect the correction process by elaborating a decision criterion that adapts the process to the most effective technique to ensure fast and reliable correction. In addition to that, problems such as bad pixels and ghosting artifacts are also dealt with to enhance the overall quality of the correction. The performance of the proposed technique is investigated and compared to the two state-of-the-art techniques cited above. PMID:27834893

Gradient-based interpolation method for division-of-focal-plane polarimeters.

PubMed

Gao, Shengkui; Gruev, Viktor

2013-01-14

Recent advancements in nanotechnology and nanofabrication have allowed for the emergence of the division-of-focal-plane (DoFP) polarization imaging sensors. These sensors capture polarization properties of the optical field at every imaging frame. However, the DoFP polarization imaging sensors suffer from large registration error as well as reduced spatial-resolution output. These drawbacks can be improved by applying proper image interpolation methods for the reconstruction of the polarization results. In this paper, we present a new gradient-based interpolation method for DoFP polarimeters. The performance of the proposed interpolation method is evaluated against several previously published interpolation methods by using visual examples and root mean square error (RMSE) comparison. We found that the proposed gradient-based interpolation method can achieve better visual results while maintaining a lower RMSE than other interpolation methods under various dynamic ranges of a scene ranging from dim to bright conditions.

Performance and Calibration of H2RG Detectors and SIDECAR ASICs for the RATIR Camera

NASA Technical Reports Server (NTRS)

Fox, Ori D.; Kutyrev, Alexander S.; Rapchun, David A.; Klein, Christopher R.; Butler, Nathaniel R.; Bloom, Josh; de Diego, Jos A.; Simn Farah, Alejandro D.; Gehrels, Neil A.; Georgiev, Leonid;

New Focal Plane Array Controller for the Instruments of the Subaru Telescope

NASA Astrophysics Data System (ADS)

Nakaya, Hidehiko; Komiyama, Yutaka; Miyazaki, Satoshi; Yamashita, Takuya; Yagi, Masafumi; Sekiguchi, Maki

2006-03-01

We have developed a next-generation data acquisition system, MESSIA5 (Modularized Extensible System for Image Acquisition), which comprises the digital part of a focal plane array controller. The new data acquisition system was constructed based on a 64 bit, 66 MHz PCI (peripheral component interconnect) bus architecture and runs on an x86 CPU computer with (non-real-time) Linux. The system, including the CPU board, is placed at the telescope focus, and standard gigabit Ethernet is adopted for the data transfer, as opposed to a dedicated fiber link. During the summer of 2002, we installed the new system for the first time on the Subaru prime-focus camera Suprime-Cam and successfully improved the observing performance.

Methodology for testing infrared focal plane arrays in simulated nuclear radiation environments

NASA Astrophysics Data System (ADS)

Divita, E. L.; Mills, R. E.; Koch, T. L.; Gordon, M. J.; Wilcox, R. A.; Williams, R. E.

1992-07-01

This paper summarizes test methodology for focal plane array (FPA) testing that can be used for benign (clear) and radiation environments, and describes the use of custom dewars and integrated test equipment in an example environment. The test methodology, consistent with American Society for Testing Materials (ASTM) standards, is presented for the total accumulated gamma dose, transient dose rate, gamma flux, and neutron fluence environments. The merits and limitations of using Cobalt 60 for gamma environment simulations and of using various fast-neutron reactors and neutron sources for neutron simulations are presented. Test result examples are presented to demonstrate test data acquisition and FPA parameter performance under different measurement conditions and environmental simulations.

Development of a hard x-ray focal plane compton polarimeter: a compact polarimetric configuration with scintillators and Si photomultipliers

NASA Astrophysics Data System (ADS)

Chattopadhyay, T.; Vadawale, S. V.; Goyal, S. K.; Mithun, N. P. S.; Patel, A. R.; Shukla, R.; Ladiya, T.; Shanmugam, M.; Patel, V. R.; Ubale, G. P.

2016-02-01

X-ray polarization measurement of cosmic sources provides two unique parameters namely degree and angle of polarization which can probe the emission mechanism and geometry at close vicinity of the compact objects. Specifically, the hard X-ray polarimetry is more rewarding because the sources are expected to be intrinsically highly polarized at higher energies. With the successful implementation of Hard X-ray optics in NuSTAR, it is now feasible to conceive Compton polarimeters as focal plane detectors. Such a configuration is likely to provide sensitive polarization measurements in hard X-rays with a broad energy band. We are developing a focal plane hard X-ray Compton polarimeter consisting of a plastic scintillator as active scatterer surrounded by a cylindrical array of CsI(Tl) scintillators. The scatterer is 5 mm diameter and 100 mm long plastic scintillator (BC404) viewed by normal PMT. The photons scattered by the plastic scatterer are collected by a cylindrical array of 16 CsI(Tl) scintillators (5 mm × 5 mm × 150 mm) which are read by Si Photomultiplier (SiPM). Use of the new generation SiPMs ensures the compactness of the instrument which is essential for the design of focal plane detectors. The expected sensitivity of such polarimetric configuration and complete characterization of the plastic scatterer, specially at lower energies have been discussed in [11, 13]. In this paper, we characterize the CsI(Tl) absorbers coupled to SiPM. We also present the experimental results from the fully assembled configuration of the Compton polarimeter.

Anti-Inflammatory Effect of Ginsenoside Rg5 in Lipopolysaccharide-Stimulated BV2 Microglial Cells

PubMed Central

Lee, Yu Young; Park, Jin-Sun; Jung, Ji-Sun; Kim, Dong-Hyun; Kim, Hee-Sun

2013-01-01

Microglia are resident immune cells in the central nervous system. They play a role in normal brain development and neuronal recovery. However, overactivation of microglia causes neuronal death, which is associated with neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. Therefore, controlling microglial activation has been suggested as an important target for treatment of neurodegenerative diseases. In the present study, we investigated the anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide (LPS)-stimulated BV2 microglial cells and rat primary microglia. The data showed that Rg5 suppressed LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. In addition, Rg5 inhibited the mRNA expressions of iNOS, TNF-α, IL-1β, COX-2 and MMP-9 induced by LPS. Further mechanistic studies revealed that Rg5 inhibited the phophorylations of PI3K/Akt and MAPKs and the DNA binding activities of NF-κB and AP-1, which are upstream molecules controlling inflammatory reactions. Moreover, Rg5 suppressed ROS production with upregulation of hemeoxygenase-1 (HO-1) expression in LPS-stimulated BV2 cells. Overall, microglial inactivation by ginsenoside Rg5 may provide a therapeutic potential for various neuroinflammatory disorders. PMID:23698769

Quantum mechanics on the h-deformed quantum plane

NASA Astrophysics Data System (ADS)

Cho, Sunggoo

1999-03-01

We find the covariant deformed Heisenberg algebra and the Laplace-Beltrami operator on the extended h-deformed quantum plane and solve the Schrödinger equations explicitly for some physical systems on the quantum plane. In the commutative limit the behaviour of a quantum particle on the quantum plane becomes that of the quantum particle on the Poincaré half-plane, a surface of constant negative Gaussian curvature. We show that the bound state energy spectra for particles under specific potentials depend explicitly on the deformation parameter h. Moreover, it is shown that bound states can survive on the quantum plane in a limiting case where bound states on the Poincaré half-plane disappear.

Development of Suitable Technologies for Heterodyne W-Band Focal-Plane Arrays

NASA Astrophysics Data System (ADS)

Mena, Patricio; Reyes, N.; Jarufe, C.; Barrueto, I.; Molina, R.; Monasterio, D.; Bronfman, L.

2018-01-01

We present the ongoing efforts at University of Chile to develop technologies for heterodyne focal-plane arrays. We have focused in W band covering four areas of study. 1. OPTICAL SYSTEMS: We have studied the possibility of using multi-pixel receivers at ALMA-type antennas. We designed an array of 7 pixels (extensible to 19) that fits into an ALMA cartridge. The design includes a set of mirrors and a fly-eye lens that allows the system to fit on the available space. For the feed, we have studied smooth-wall horns and Vivaldi antennas. 2. COMPACT OMTS: We have been working on turnstile-type OMTs fabricated in platelets that permit integration of several OMTs in the same block. 3. LOW NOISE AMPLIFIERS: We are working on a hybrid concept that uses a single transistor mounted before a commercial MMIC. We have measured noise temperatures lower than 50 K. The aim is to produce compact blocks suitable for integration. 4. DOWNCONVERTING MIXERS: We have designed biased sub-harmonic mixers based on Schottky diodes using MMIC technology and to be fabricated in a commercial run. We expect conversion losses below 15 dB. Mixers and LNA will be packaged in a single block using a 2SB scheme.

Stress analysis of the space telescope focal plane structure joint

NASA Technical Reports Server (NTRS)

Foster, W. A., Jr.; Shoemaker, W. L.

1985-01-01

Two major efforts were begun concerning the Space Telescope focal plane structure joint. The 3-D solid finite element modeling of the bipod flexure plate was carried out. Conceptual models were developed for the load transfer through the three major bolts to the flexure plate. The flexure plate drawings were reconstructed using DADAM for the purpose of developing a file from which the coordinates of any point on the flexure plate could be determined and also to locate the attachment points of the various components which connect with the flexure plate. For modeling convenience the CADAM drawing of the flexure plate has been divided into several regions which will be subdivided into finite elements using MSGMESH, which is a finite element mesh generator available with MSC/NASTRAN. In addition to the CADAM work on the flexure plate, an effort was also begun to develop computer aided drawings of the peripheral beam which will be used to assist in modeling the connection between it and the flexure plate.

Scene-based nonuniformity correction technique for infrared focal-plane arrays.

PubMed

Liu, Yong-Jin; Zhu, Hong; Zhao, Yi-Gong

2009-04-20

A scene-based nonuniformity correction algorithm is presented to compensate for the gain and bias nonuniformity in infrared focal-plane array sensors, which can be separated into three parts. First, an interframe-prediction method is used to estimate the true scene, since nonuniformity correction is a typical blind-estimation problem and both scene values and detector parameters are unavailable. Second, the estimated scene, along with its corresponding observed data obtained by detectors, is employed to update the gain and the bias by means of a line-fitting technique. Finally, with these nonuniformity parameters, the compensated output of each detector is obtained by computing a very simple formula. The advantages of the proposed algorithm lie in its low computational complexity and storage requirements and ability to capture temporal drifts in the nonuniformity parameters. The performance of every module is demonstrated with simulated and real infrared image sequences. Experimental results indicate that the proposed algorithm exhibits a superior correction effect.

Multiple detector focal plane array ultraviolet spectrometer for the AMPS laboratory

NASA Technical Reports Server (NTRS)

Feldman, P. D.

1975-01-01

The possibility of meeting the requirements of the amps spectroscopic instrumentation by using a multi-element focal plane detector array in a conventional spectrograph mount was examined. The requirements of the detector array were determined from the optical design of the spectrometer which in turn depends on the desired level of resolution and sensitivity required. The choice of available detectors and their associated electronics and controls was surveyed, bearing in mind that the data collection rate from this system is so great that on-board processing and reduction of data are absolutely essential. Finally, parallel developments in instrumentation for imaging in astronomy were examined, both in the ultraviolet (for the Large Space Telescope as well as other rocket and satellite programs) and in the visible, to determine what progress in that area can have direct bearing on atmospheric spectroscopy.

Theoretical Study of Group 14 M^{+}(^{2}P_{J})-RG Complexes (M^{+} = C^{+}, Si^{+}; RG = he - Ar)

NASA Astrophysics Data System (ADS)

Tuttle, William Duncan; Thorington, Rebecca L.; Wright, Timothy G.; Viehland, Larry A.

2017-06-01

The light group 14 cations are found in a wide variety of environments, with, for example, C^{+} ions thought to play a key role in the chemistry of the interstellar medium, while Si^{+} ions are an important component of the upper atmosphere of the Earth due to their presence in meteoroids. We calculate accurate interatomic potentials for a singly charged carbon cation and a singly charged silicon cation interacting with the rare gas atoms helium, neon and argon. The RCCSD(T) method is employed, with basis sets of quadruple-ζ and quintuple-ζ quality, and the energies counterpoise corrected and extrapolated to the basis set limit at each point. In all cases, we consider the lowest electronic states of the M^{+} atom, (^{2}P_{J}), interacting with the ground electronic state of the RG atom, (^{1}S_{0}), and compute potentials corresponding to the molecular terms, ^{2}Π and ^{2}Σ^{+}, as well as the spin-orbit levels which arise: ^{2}Π_{3/2}, ^{2}Π_{1/2} and ^{2}Σ_{1/2}^{+}. The potentials are employed to calculated spectroscopic constants and ion transport properties. S. Petrie and D. K. Bohme, Mass Spec. Rev., 26, 258 (2007). J. M. C. Plane, J. C. Gómez-Martin, W. Feng, and D. Janches, J. Geophys. Res. Atmos. 121, 3718 (2016). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright, Mol. Phys. 113, 3767 (2015). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright (in preparation). W. D. Tuttle, R. L. Thorington, L. A. Viehland and T. G. Wright, Mol. Phys. 115, 437 (2017).

Detectors and Focal Plane Modules for Weather Instruments

NASA Technical Reports Server (NTRS)

D'Souza, A.I.; Robinson, E.; Masterjohn, S.; Khalap, V.; Bhargava, S.; Rangel, E.; Babu, S.; Smith, D. S.

2016-01-01

Weather satellite instruments require detectors with a variety of wavelengths ranging from the visible to VLWIR. The Cross-track infrared Sounder (CrIS) is a Polar Orbiting interferometric sensor that measures earth radiances at high spectral resolution, using the data to provide pressure, temperature and moisture profiles of the atmosphere. The pressure, temperature and moisture sounding data are used in weather prediction models that track storms, predict levels of precipitation etc. The CrIS instrument contains SWIR (lambda(sub c) (is) approximately 5 micrometers at 98 K), MWIR (lambda(sub c) (is) approximately 9 micrometers at 98 K) and LWIRs (lambda(sub c) (is) approximately 15.4 ?m at 81 K) bands in three Focal Plane Array Assemblies (FPAAs). CrIS detectors are 850 micrometers diameter detectors with each FPAA consisting of nine photovoltaic detectors arranged in a 3 x 3 pattern. Molecular beam epitaxy (MBE)-grown Hg1-xCdxTe material are used for the detectors fabricated in a modified Double Layer Planar Heterostructure (DLPH) architecture. Each detector has an accompanying cold preamplifier. SWIR and MWIR FPAAs operate at 98 K and the LWIR FPAA at 81 K, permitting the use of passive radiators to cool the detectors. D* requirements at peak 14.01 micrometers wavelength are greater than 5.0E+10 Jones for LWIR, greater than 7.5E+10 Jones at 8.26 micrometers for MWIR and greater than 3.0E+11 Jones at peak 4.64 micrometers wavelength for SWIR. All FPAAs exceeded the D* requirements. Measured mean values for the nine photodiodes in each of the LWIR, MWIR and SWIR FPAAs are D* = 5.3 x 10(exp 10) cm-Hz1/2/W at 14.0 micrometers, 9.6 x 10(exp 10) cm-Hz1/2/W at 8.0 micrometers and 3.4 x 10(exp 11) cm-Hz1/2/W at 4.64 micrometers.

Statistical framework for the utilization of simultaneous pupil plane and focal plane telemetry for exoplanet imaging. I. Accounting for aberrations in multiple planes.

PubMed

Frazin, Richard A

2016-04-01

A new generation of telescopes with mirror diameters of 20 m or more, called extremely large telescopes (ELTs), has the potential to provide unprecedented imaging and spectroscopy of exoplanetary systems, if the difficulties in achieving the extremely high dynamic range required to differentiate the planetary signal from the star can be overcome to a sufficient degree. Fully utilizing the potential of ELTs for exoplanet imaging will likely require simultaneous and self-consistent determination of both the planetary image and the unknown aberrations in multiple planes of the optical system, using statistical inference based on the wavefront sensor and science camera data streams. This approach promises to overcome the most important systematic errors inherent in the various schemes based on differential imaging, such as angular differential imaging and spectral differential imaging. This paper is the first in a series on this subject, in which a formalism is established for the exoplanet imaging problem, setting the stage for the statistical inference methods to follow in the future. Every effort has been made to be rigorous and complete, so that validity of approximations to be made later can be assessed. Here, the polarimetric image is expressed in terms of aberrations in the various planes of a polarizing telescope with an adaptive optics system. Further, it is shown that current methods that utilize focal plane sensing to correct the speckle field, e.g., electric field conjugation, rely on the tacit assumption that aberrations on multiple optical surfaces can be represented as aberration on a single optical surface, ultimately limiting their potential effectiveness for ground-based astronomy.

Local Explosion Monitoring using Rg

NASA Astrophysics Data System (ADS)

O'Rourke, C. T.; Baker, G. E.

2016-12-01

Rg is the high-frequency fundamental-mode Rayleigh wave, which is only excited by near-surface events. As such, an Rg detection indicates that a seismic source is shallow, generally less than a few km depending on the velocity structure, and so likely man-made. Conversely, the absence of Rg can indicate that the source is deeper and so likely naturally occurring. We have developed a new automated method of detecting Rg arrivals from various explosion sources at local distances, and a process for estimating the likelihood that a source is not shallow when no Rg is detected. Our Rg detection method scans the spectrogram of a seismic signal for a characteristic frequency peak. We test this on the Bighorn Arch Seismic Experiment data, which includes earthquakes, active source explosions in boreholes, and mining explosions recorded on a dense network that spans the Bighorn Mountains and Powder River Basin. The Rg passbands used were 0.4-0.8 Hz for mining blasts and 0.8-1.2 Hz for borehole shots. We successfully detect Rg across the full network for most mining blasts. The lower-yield shots are detectable out to 50 km. We achieve <1% false-positive rate for the small-magnitude earthquakes in the region. Rg detections on known non-shallow earthquake seismograms indicates they are largely due to windowing leakage at very close distances or occasionally to cultural noise. We compare our results to existing methods that use cross-correlation to detect retrograde motion of the surface waves. Our method shows more complete detection across the network, especially in the Powder River Basin where Rg exhibits prograde motion that does not trigger the existing detector. We also estimate the likelihood that Rg would have been detected from a surface source, based on the measured P amplitude. For example, an event with a large P wave and no detectable Rg would have a high probability of being a deeper event, whereas we cannot confidently determine whether an event with a small P

In-plane Schottky-barrier field-effect transistors based on 1T/2H heterojunctions of transition-metal dichalcogenides

NASA Astrophysics Data System (ADS)

Fan, Zhi-Qiang; Jiang, Xiang-Wei; Luo, Jun-Wei; Jiao, Li-Ying; Huang, Ru; Li, Shu-Shen; Wang, Lin-Wang

2017-10-01

As Moore's law approaches its end, two-dimensional (2D) materials are intensely studied for their potentials as one of the "More than Moore' (MM) devices. However, the ultimate performance limits and the optimal design parameters for such devices are still unknown. One common problem for the 2D-material-based device is the relative weak on-current. In this study, two-dimensional Schottky-barrier field-effect transistors (SBFETs) consisting of in-plane heterojunctions of 1T metallic-phase and 2H semiconducting-phase transition-metal dichalcogenides (TMDs) are studied following the recent experimental synthesis of such devices at a much larger scale. Our ab initio simulation reveals the ultimate performance limits of such devices and offers suggestions for better TMD materials. Our study shows that the Schottky-barrier heights (SBHs) of the in-plane 1T/2H contacts are smaller than the SBHs of out-of-plane contacts, and the contact coupling is also stronger in the in-plane contact. Due to the atomic thickness of the monolayer TMD, the average subthreshold swing of the in-plane TMD-SBFETs is found to be close to the limit of 60 mV/dec, and smaller than that of the out-of-plane TMD-SBFET device. Different TMDs are considered and it is found that the in-plane WT e2-SBFET provides the best performance and can satisfy the performance requirement of the sub-10-nm high-performance transistor outlined by the International Technology Roadmap for Semiconductors, and thus could be developed into a viable sub-10-nm MM device in the future.

Silent IL2RG Gene Editing in Human Pluripotent Stem Cells.

PubMed

Li, Li B; Ma, Chao; Awong, Geneve; Kennedy, Marion; Gornalusse, German; Keller, Gordon; Kaufman, Dan S; Russell, David W

2016-03-01

Many applications of pluripotent stem cells (PSCs) require efficient editing of silent chromosomal genes. Here, we show that a major limitation in isolating edited clones is silencing of the selectable marker cassette after homologous recombination and that this can be overcome by using a ubiquitous chromatin opening element (UCOE) promoter-driven transgene. We use this strategy to edit the silent IL2RG locus in human PSCs with a recombinant adeno-associated virus (rAAV)-targeting vector in the absence of potentially genotoxic, site-specific nucleases and show that IL2RG is required for natural killer and T-cell differentiation of human PSCs. Insertion of an active UCOE promoter into a silent locus altered the histone modification and cytosine methylation pattern of surrounding chromatin, but these changes resolved when the UCOE promoter was removed. This same approach could be used to correct IL2RG mutations in X-linked severe combined immunodeficiency patient-derived induced PSCs (iPSCs), to prevent graft versus host disease in regenerative medicine applications, or to edit other silent genes.

Radiometric packaging of uncooled bolometric infrared focal plane arrays

NASA Astrophysics Data System (ADS)

García-Blanco, Sonia; Pope, Timothy; Côté, Patrice; Leclerc, Mélanie; Ngo Phong, Linh; Châteauneuf, François

2017-11-01

INO has a wide experience in the design and fabrication of different kinds of microbolometer focal plane arrays (FPAs). In particular, a 512x3 pixel microbolometer FPA has been selected as the sensor for the New Infrared Sensor Technology (NIRST) instrument, one of the payloads of the SACD/Aquarius mission. In order to make the absolute temperature measurements necessary for many infrared Earth observation applications, the microbolometer FPA must be integrated into a package offering a very stable thermal environment. The radiometric packaging technology developed at INO presents an innovative approach since it was conceived to be modular and adaptable for the packaging of different microbolometer FPAs and for different sets of assembly requirements without need for requalification of the assembly process. The development of the radiometric packaging technology has broadened the position of INO as a supplier of radiometric detector modules integrating FPAs of microbolometers inside a radiometric package capable of achieving the requirements of different space missions. This paper gives an overview of the design of INO's radiometric package. Key performance parameters are also discussed and the test campaign conducted with the radiometric package is presented.

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice*

PubMed Central

Yang, Xiaodong; Mudgett, John; Bou-About, Ghina; Champy, Marie-France; Jacobs, Hugues; Monassier, Laurent; Pavlovic, Guillaume; Sorg, Tania; Herault, Yann; Petit-Demoulière, Benoit; Lu, Ku; Feng, Wen; Wang, Hongwu; Ma, Li-Jun; Askew, Roger; Erion, Mark D.; Kelley, David E.; Myers, Robert W.; Li, Cai

2016-01-01

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2NI or AMPKγ2RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype. To investigate whether physiological levels of AMPKγ2NI or AMPKγ2RG mutation cause WPW syndrome and metabolic changes in other organs, we generated two knock-in mouse lines on the C57BL/6N background harboring mutations of human AMPKγ2NI and AMPKγ2RG, respectively. Similar to the reported phenotypes of mice overexpressing AMPKγ2NI or AMPKγ2RG in the heart, both lines developed WPW syndrome and cardiac hypertrophy; however, these effects were independent of cardiac glycogen accumulation. Compared with AMPKγ2WT mice, AMPKγ2NI and AMPKγ2RG mice exhibited reduced body weight, fat mass, and liver steatosis when fed with a high fat diet (HFD). Surprisingly, AMPKγ2RG but not AMPKγ2NI mice fed with an HFD exhibited severe kidney injury characterized by glycogen accumulation, inflammation, apoptosis, cyst formation, and impaired renal function. These results demonstrate that expression of AMPKγ2NI and AMPKγ2RG mutations at physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW syndrome. Our data also reveal an unexpected effect of AMPKγ2RG in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for kidney dysfunction in the context of an HFD. PMID:27621313

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

PubMed

Yang, Xiaodong; Mudgett, John; Bou-About, Ghina; Champy, Marie-France; Jacobs, Hugues; Monassier, Laurent; Pavlovic, Guillaume; Sorg, Tania; Herault, Yann; Petit-Demoulière, Benoit; Lu, Ku; Feng, Wen; Wang, Hongwu; Ma, Li-Jun; Askew, Roger; Erion, Mark D; Kelley, David E; Myers, Robert W; Li, Cai; Guan, Hong-Ping

2016-11-04

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2 NI ) and R531G (AMPKγ2 RG ), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2 NI or AMPKγ2 RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype. To investigate whether physiological levels of AMPKγ2 NI or AMPKγ2 RG mutation cause WPW syndrome and metabolic changes in other organs, we generated two knock-in mouse lines on the C57BL/6N background harboring mutations of human AMPKγ2 NI and AMPKγ2 RG , respectively. Similar to the reported phenotypes of mice overexpressing AMPKγ2 NI or AMPKγ2 RG in the heart, both lines developed WPW syndrome and cardiac hypertrophy; however, these effects were independent of cardiac glycogen accumulation. Compared with AMPKγ2 WT mice, AMPKγ2 NI and AMPKγ2 RG mice exhibited reduced body weight, fat mass, and liver steatosis when fed with a high fat diet (HFD). Surprisingly, AMPKγ2 RG but not AMPKγ2 NI mice fed with an HFD exhibited severe kidney injury characterized by glycogen accumulation, inflammation, apoptosis, cyst formation, and impaired renal function. These results demonstrate that expression of AMPKγ2 NI and AMPKγ2 RG mutations at physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW syndrome. Our data also reveal an unexpected effect of AMPKγ2 RG in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for kidney dysfunction in the context of an HFD. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Large Format Narrow-Band, Multi-Band, and Broad-Band LWIR QWIP Focal Planes for Space and Earth Science Applications

NASA Technical Reports Server (NTRS)

Gunapala, S. D.; Bandara, S. V.

2004-01-01

A 640x512 pixel, long-wavelength cutoff, narrow-band (delta(lambda)/approx. 10%) quantum well infrared photodetector (QWIP) focal plane array (FPA), a four-band QWIP FPA in the 4-16 m spectral region, and a broad-band (delta(lambda)/approx. 42%) QWIP FPA having 15.4 m cutoff have been demonstrated.

Noise-cancellation-based nonuniformity correction algorithm for infrared focal-plane arrays.

PubMed

Godoy, Sebastián E; Pezoa, Jorge E; Torres, Sergio N

2008-10-10

The spatial fixed-pattern noise (FPN) inherently generated in infrared (IR) imaging systems compromises severely the quality of the acquired imagery, even making such images inappropriate for some applications. The FPN refers to the inability of the photodetectors in the focal-plane array to render a uniform output image when a uniform-intensity scene is being imaged. We present a noise-cancellation-based algorithm that compensates for the additive component of the FPN. The proposed method relies on the assumption that a source of noise correlated to the additive FPN is available to the IR camera. An important feature of the algorithm is that all the calculations are reduced to a simple equation, which allows for the bias compensation of the raw imagery. The algorithm performance is tested using real IR image sequences and is compared to some classical methodologies. (c) 2008 Optical Society of America

Nonuniformity correction algorithm with efficient pixel offset estimation for infrared focal plane arrays.

PubMed

Orżanowski, Tomasz

2016-01-01

This paper presents an infrared focal plane array (IRFPA) response nonuniformity correction (NUC) algorithm which is easy to implement by hardware. The proposed NUC algorithm is based on the linear correction scheme with the useful method of pixel offset correction coefficients update. The new approach to IRFPA response nonuniformity correction consists in the use of pixel response change determined at the actual operating conditions in relation to the reference ones by means of shutter to compensate a pixel offset temporal drift. Moreover, it permits to remove any optics shading effect in the output image as well. To show efficiency of the proposed NUC algorithm some test results for microbolometer IRFPA are presented.

Large size MOEMS Fabry-Perot interferometer filter for focal plane array hyperspectral imaging

NASA Astrophysics Data System (ADS)

Chee, J.; Hwu, J.; Kim, T. S.; Kubby, J.; Velicu, S.; Gupta, N.

2015-02-01

Focal plane array (FPA) technology is mature and is widely used for imaging applications. However, FPAs have broadband responses which limit their ability to provide high performance in hyperspectral applications such as detection of buried explosives, and identifying the presence of explosive chemicals and their concentrations. EPIR is currently developing Micro-Opto-Electro-Mechanical System (MOEMS) Fabry-Perot interferometer filter (FPF) devices for FPAs. In this paper, we present our approach to MOEMS FPF design and fabrication that will meet the size requirements for large format FPA hyperspectral imaging. We also report the performance of our FPF resonance cavity, capable of up to 3 μm change gap in tens of nanometer increments.

Radiation Channels Close to a Plasmonic Nanowire Visualized by Back Focal Plane Imaging

PubMed Central

Hartmann, Nicolai; Piatkowski, Dawid; Ciesielski, Richard; Mackowski, Sebastian; Hartschuh, Achim

2014-01-01

We investigated the angular radiation patterns, a key characteristic of an emitting system, from individual silver nanowires decorated with rare earth ion-doped nanocrystals. Back focal plane radiation patterns of the nanocrystal photoluminescence after local two-photon excitation can be described by two emission channels: Excitation of propagating surface plasmons in the nanowire followed by leakage radiation and direct dipolar emission observed also in the absence of the nanowire. Theoretical modeling reproduces the observed radiation patterns which strongly depend on the position of excitation along the nanowire. Our analysis allows to estimate the branching ratio into both emission channels and to determine the diameter dependent surface plasmon quasi-momentum, important parameters of emitter-plasmon structures. PMID:24131299

Time resolved photo-luminescent decay characterization of mercury cadmium telluride focal plane arrays

DOE PAGES

Soehnel, Grant

2015-01-20

The minority carrier lifetime is a measurable material property that is an indication of infrared detector device performance. To study the utility of measuring the carrier lifetime, an experiment has been constructed that can time resolve the photo-luminescent decay of a detector or wafer sample housed inside a liquid nitrogen cooled Dewar. Motorized stages allow the measurement to be scanned over the sample surface, and spatial resolutions as low as 50µm have been demonstrated. A carrier recombination simulation was developed to analyze the experimental data. Results from measurements performed on 4 mercury cadmium telluride focal plane arrays show strong correlationmore » between spatial maps of the lifetime, dark current, and relative response.« less

Nonexistence of exact solutions agreeing with the Gaussian beam on the beam axis or in the focal plane

NASA Astrophysics Data System (ADS)

Lekner, John; Andrejic, Petar

2018-01-01

Solutions of the Helmholtz equation which describe electromagnetic beams (and also acoustic or particle beams) are discussed. We show that an exact solution which reproduces the Gaussian beam waveform on the beam axis does not exist. This is surprising, since the Gaussian beam is a solution of the paraxial equation, and thus supposedly accurate on and near the beam axis. Likewise, a solution of the Helmholtz equation which exactly reproduces the Gaussian beam in the focal plane does not exist. We show that the last statement also holds for Bessel-Gauss beams. However, solutions of the Helmholtz equation (one of which is discussed in detail) can approximate the Gaussian waveform within the central focal region.

MTF measurements of a type-II superlattice infrared focal plane array sealed in a cryocooler.

PubMed

Nghiem, Jean; Jaeck, Julien; Primot, Jerome; Coudrain, Christophe; Derelle, Sophie; Huard, Edouard; Caes, Marcel; Bernhardt, Sylvie; Haidar, Riad; Christol, Philippe; Ribet-Mohamed, Isabelle

2018-04-16

In operational electro-optical systems, infrared focal plane arrays (IR FPA) are integrated in cryocoolers which induce vibrations that may strongly affect their modulation transfer function (MTF). In this paper, we present the MTF measurement of an IR FPA sealed in its cryocooler. The method we use to measure the MTF decorrelates operational constraints and the technological limitations of the IR FPA. The bench is based on the diffraction properties of a continuously self imaging grating (CSIG). The 26 µm pixel size extracted from the MTF measurement is in good agreement with the expected value.

An All Silicon Feedhorn-Coupled Focal Plane for Cosmic Microwave Background Polarimetry

NASA Technical Reports Server (NTRS)

Hubmayr, J.; Appel, J. W.; Austermann, J. E.; Beall, J. A.; Becker, D.; Benson, B. A.; Bleem, L. E.; Carlstrom, J. E.; Chang, C. L.; Cho, H. M.;

Enchanced interference cancellation and telemetry reception in multipath environments with a single paraboic dish antenna using a focal plane array

NASA Technical Reports Server (NTRS)

Vilnrotter, Victor A. (Inventor); Mukai, Ryan (Inventor)

2011-01-01

An Advanced Focal Plane Array ("AFPA") for parabolic dish antennas that exploits spatial diversity to achieve better channel equalization performance in the presence of multipath (better than temporal equalization alone), and which is capable of receiving from two or more sources within a field-of-view in the presence of multipath. The AFPA uses a focal plane array of receiving elements plus a spatio-temporal filter that keeps information on the adaptive FIR filter weights, relative amplitudes and phases of the incoming signals, and which employs an Interference Cancelling Constant Modulus Algorithm (IC-CMA) that resolves multiple telemetry streams simultaneously from the respective aero-nautical platforms. This data is sent to an angle estimator to calculate the target's angular position, and then on to Kalman filters FOR smoothing and time series prediction. The resulting velocity and acceleration estimates from the time series data are sent to an antenna control unit (ACU) to be used for pointing control.

Development of Ultra-Low Noise, High Performance III-V Quantum Well Infrared Photodetectors (QWIPs) for Focal Plane Array Staring Image Sensor Systems

DTIC Science & Technology

1993-08-01

Development of Ultra-Low Noise , High Performance III-V Quantum Well Infrared Photodetectors ( QWIPs ) for Focal Plane Array Staring Image Sensor Systems...using a 2-D square mesh grating coupler to achieve maximum responsivity for an InGaAs SBTM QWIP , and (iv) performed noise characterization on four...different types of Ir-V QWIPs and identified their noise sources. Detailed results and accomplishments are discussed in this report. 1 SJ •aTEtcRMrtlS

Biotransformation of ginsenosides F4 and Rg6 in zebrafish.

PubMed

Shen, Wen-Wen; Zhang, Hai-Xia; Qiu, Shou-Bei; Wei, Ying-Jie; Zhu, Fen-Xia; Wang, Jing; Wang, Dan-Dan; Jia, Xiao-Bin; Tang, Dao-Quan; Chen, Bin

2017-03-28

Ginsenosides F 4 and Rg 6 (GF 4 and GRg 6 ), two main active components of steamed notoginseng or red ginseng, are dehydrated disaccharide saponins. In this work, biotransformation of ginsenosides F 4 and Rg 6 in zebrafish was investigated by qualitatively identifying their metabolites and then proposing their possible metabolic pathways. The prediction of possible metabolism of ginsenosides F 4 and Rg 6 using zebrafish model which can effectively simulate existing mammals model was early and quickly performed. Metabolites of ginsenosides F 4 and Rg 6 after exposing to zebrafish for 24 h were identified by Ultraperformance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry. A total of 8 and 6 metabolites of ginsenosides F 4 and Rg 6 were identified in zebrafish, respectively. Of these, 7 and 5, including M1, M3-M5, M7-M9 and N1 (N5), N2, N4 (N9), N7-N8 were reported for the first time as far as we know. The mechanisms of their biotransformation involved were further deduced to be desugarization, glucuronidation, sulfation, dehydroxylation, loss of C-17 and/or C-23 residue pathways. It was concluded that loss of rhamnose at position C-6 and glucuronidation at position C-3 in zebrafish were considered as the main physiologic and metabolic processes of ginsenosides F 4 and ginsenosides Rg 6 , respectively.

Evolution of miniature detectors and focal plane arrays for infrared sensors

NASA Astrophysics Data System (ADS)

Watts, Louis A.

1993-06-01

Sensors that are sensitive in the infrared spectral region have been under continuous development since the WW2 era. A quest for the military advantage of 'seeing in the dark' has pushed thermal imaging technology toward high spatial and temporal resolution for night vision equipment, fire control, search track, and seeker 'homing' guidance sensing devices. Similarly, scientific applications have pushed spectral resolution for chemical analysis, remote sensing of earth resources, and astronomical exploration applications. As a result of these developments, focal plane arrays (FPA) are now available with sufficient sensitivity for both high spatial and narrow bandwidth spectral resolution imaging over large fields of view. Such devices combined with emerging opto-electronic developments in integrated FPA data processing techniques can yield miniature sensors capable of imaging reflected sunlight in the near IR and emitted thermal energy in the Mid-wave (MWIR) and longwave (LWIR) IR spectral regions. Robotic space sensors equipped with advanced versions of these FPA's will provide high resolution 'pictures' of their surroundings, perform remote analysis of solid, liquid, and gas matter, or selectively look for 'signatures' of specific objects. Evolutionary trends and projections of future low power micro detector FPA developments for day/night operation or use in adverse viewing conditions are presented in the following test.

Evolution of miniature detectors and focal plane arrays for infrared sensors

NASA Technical Reports Server (NTRS)

Watts, Louis A.

1993-01-01

Sensors that are sensitive in the infrared spectral region have been under continuous development since the WW2 era. A quest for the military advantage of 'seeing in the dark' has pushed thermal imaging technology toward high spatial and temporal resolution for night vision equipment, fire control, search track, and seeker 'homing' guidance sensing devices. Similarly, scientific applications have pushed spectral resolution for chemical analysis, remote sensing of earth resources, and astronomical exploration applications. As a result of these developments, focal plane arrays (FPA) are now available with sufficient sensitivity for both high spatial and narrow bandwidth spectral resolution imaging over large fields of view. Such devices combined with emerging opto-electronic developments in integrated FPA data processing techniques can yield miniature sensors capable of imaging reflected sunlight in the near IR and emitted thermal energy in the Mid-wave (MWIR) and longwave (LWIR) IR spectral regions. Robotic space sensors equipped with advanced versions of these FPA's will provide high resolution 'pictures' of their surroundings, perform remote analysis of solid, liquid, and gas matter, or selectively look for 'signatures' of specific objects. Evolutionary trends and projections of future low power micro detector FPA developments for day/night operation or use in adverse viewing conditions are presented in the following test.

Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1.

PubMed

Zheng, Hui-Zhen; Fu, Xue-Kun; Shang, Jiu-Long; Lu, Rong-Xi; Ou, Yong-Fang; Chen, Chun-Ling

2018-03-05

This study aimed to verify the cytoprotective effect of ginsenoside Rg1 in vivo, and to elucidate the mechanism of Rg1 in the ischemic microenvironment. Male rat bone marrow mesenchymal stem cells (rBMSCs) or rBMSCs treated with Rg1 were injected into ischemic region of the arterial embolism hind limb in female rats. Behavioral and histological data, obtained one-week post injection, showed that rBMSCs with Rg1 could improve the survival rate of BMSCs and enhance the therapeutic effects. rBMSCs treated with hypoxia and serum deprivation for 24h (H/SD-rBMSCs) showed the up-regulated expression of ras homolog family member A (RhoA), Rho associated coiled-coil containing protein kinase 1 (ROCK-1), myosin light chain 2 (MLC-2), Bcl2 associated agonist of cell death (Bad) and Bcl2 associated X, apoptosis regulator (Bax); while the expression of miR-148b-3p, miR-148b-5p and miR-494-3p was down-regulated. H/SD with Rg1 treatment (H/SD+Rg1-rBMSCs) inhibited the expression of ROCK-1, MLC-2, Bad and Bax, increased the expression of Bcl-2, miR-494-3p. After ROCK-1 knockout, the expression of Bad and Bax were downregulated and Bcl-2 upregulated, but Rg1 no longer altered their expression. Mir-494-3p functional study established that miR-494-3 mimic downregulated and miR-494-3 inhibitor upregulated ROCK-1 gene expression, Rg1 did not have the ability to change the ROCK gene expression after loss of function of miR-494-3p. Also, the function loss of mir-494-3p promoted apoptosis; otherwise reduced apoptosis. The anti-apoptotic effect of Rg1 disappeared after mir-494-3p loss or gain function. In conclusion, Ginsenoside Rg1 has shown to have protective effects on ischemic-induced rBMSCs apoptosis through mir-494-3p→ROCK-1→Bcl-2 signaling pathway. Copyright © 2018. Published by Elsevier B.V.

NbN A/D Conversion of IR Focal Plane Sensor Signal at 10 K

NASA Technical Reports Server (NTRS)

Eaton, L.; Durand, D.; Sandell, R.; Spargo, J.; Krabach, T.

1994-01-01

We are implementing a 12 bit SFQ counting ADC with parallel-to-serial readout using our established 10 K NbN capability. This circuit provides a key element of the analog signal processor (ASP) used in large infrared focal plane arrays. The circuit processes the signal data stream from a Si:As BIB detector array. A 10 mega samples per second (MSPS) pixel data stream flows from the chip at a 120 megabit bit rate in a format that is compatible with other superconductive time dependent processor (TDP) circuits being developed. We will discuss our planned ASP demonstration, the circuit design, and test results.

The CHROMA focal plane array: a large-format, low-noise detector optimized for imaging spectroscopy

NASA Astrophysics Data System (ADS)

Demers, Richard T.; Bailey, Robert; Beletic, James W.; Bernd, Steve; Bhargava, Sidharth; Herring, Jason; Kobrin, Paul; Lee, Donald; Pan, Jianmei; Petersen, Anders; Piquette, Eric; Starr, Brian; Yamamoto, Matthew; Zandian, Majid

2013-09-01

The CHROMA (Configurable Hyperspectral Readout for Multiple Applications) is an advanced Focal Plane Array (FPA) designed for visible-infrared imaging spectroscopy. Using Teledyne's latest substrateremoved HgCdTe detector, the CHROMA FPA has very low dark current, low readout noise and high, stable quantum efficiency from the deep blue (390nm) to the cutoff wavelength. CHROMA has a pixel pitch of 30 microns and is available in array formats ranging from 320×480 to 1600×480 pixels. Users generally disperse spectra over the 480 pixel-length columns and image spatially over the n×160 pixellength rows, where n=2, 4, 8, 10. The CHROMA Readout Integrated Circuit (ROIC) has Correlated Double Sampling (CDS) in pixel and generates its own internal bias signals and clocks. This paper presents the measured performance of the CHROMA FPA with 2.5 micron cutoff wavelength including the characterization of noise versus pixel gain, power dissipation and quantum efficiency.

Direct view zoom scope with single focal plane and adaptable reticle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bagwell, Brett

A direct view telescopic sight includes objective lens, eyepiece, and prism erector assemblies. The objective lens assembly is mounted to receive light of an image from an object direction and direct the light along an optical path. The eyepiece assembly is mounted to receive the light along the optical path and to emit the light of the image along an eye-ward direction. The prism erector assembly is positioned between the objective lens and eyepiece assemblies and includes first and second prism elements through which the optical path passes. The first and second prism elements invert the image. A reticle elementmore » is disposed on or adjacent to a surface of one of the first or second prism elements to combine a reticle on the image. The image is brought into focus at only a single focal plane between the objective lens and eyepiece assemblies at a given time.« less

Counting RG flows

DOE PAGES

Gukov, Sergei

2016-01-05

Here, interpreting renormalization group flows as solitons interpolating between different fixed points, we ask various questions that are normally asked in soliton physics but not in renormalization theory. Can one count RG flows? Are there different "topological sectors" for RG flows? What is the moduli space of an RG flow, and how does it compare to familiar moduli spaces of (supersymmetric) dowain walls? Analyzing these questions in a wide variety of contexts -- from counting RG walls to AdS/CFT correspondence -- will not only provide favorable answers, but will also lead us to a unified general framework that is powerfulmore » enough to account for peculiar RG flows and predict new physical phenomena. Namely, using Bott's version of Morse theory we relate the topology of conformal manifolds to certain properties of RG flows that can be used as precise diagnostics and "topological obstructions" for the strong form of the C-theorem in any dimension. Moreover, this framework suggests a precise mechanism for how the violation of the strong C-theorem happens and predicts "phase transitions" along the RG flow when the topological obstruction is non-trivial. Along the way, we also find new conformal manifolds in well-known 4d CFT's and point out connections with the superconformal index and classifying spaces of global symmetry groups.« less

Cosmology Large Angular Scale Surveyor (CLASS) Focal Plane Development

NASA Technical Reports Server (NTRS)

Chuss, D. T.; Ali, A.; Amiri, M.; Appel, J.; Bennett, C. L.; Colazo, F.; Denis, K. L.; Dunner, R.; Essinger-Hileman, T.; Eimer, J.;

Cosmology Large Angular Scale Surveyor (CLASS) Focal Plane Development

NASA Astrophysics Data System (ADS)

Chuss, D. T.; Ali, A.; Amiri, M.; Appel, J.; Bennett, C. L.; Colazo, F.; Denis, K. L.; Dünner, R.; Essinger-Hileman, T.; Eimer, J.; Fluxa, P.; Gothe, D.; Halpern, M.; Harrington, K.; Hilton, G.; Hinshaw, G.; Hubmayr, J.; Iuliano, J.; Marriage, T. A.; Miller, N.; Moseley, S. H.; Mumby, G.; Petroff, M.; Reintsema, C.; Rostem, K.; U-Yen, K.; Watts, D.; Wagner, E.; Wollack, E. J.; Xu, Z.; Zeng, L.

2016-08-01

The Cosmology Large Angular Scale Surveyor (CLASS) will measure the polarization of the Cosmic Microwave Background to search for and characterize the polarized signature of inflation. CLASS will operate from the Atacama Desert and observe ˜ 70 % of the sky. A variable-delay polarization modulator provides modulation of the polarization at ˜ 10 Hz to suppress the 1/ f noise of the atmosphere and enable the measurement of the large angular scale polarization modes. The measurement of the inflationary signal across angular scales that spans both the recombination and reionization features allows a test of the predicted shape of the polarized angular power spectra in addition to a measurement of the energy scale of inflation. CLASS is an array of telescopes covering frequencies of 38, 93, 148, and 217 GHz. These frequencies straddle the foreground minimum and thus allow the extraction of foregrounds from the primordial signal. Each focal plane contains feedhorn-coupled transition-edge sensors that simultaneously detect two orthogonal linear polarizations. The use of single-crystal silicon as the dielectric for the on-chip transmission lines enables both high efficiency and uniformity in fabrication. Integrated band definition has been implemented that both controls the bandpass of the single-mode transmission on the chip and prevents stray light from coupling to the detectors.

Readout circuit with novel background suppression for long wavelength infrared focal plane arrays

NASA Astrophysics Data System (ADS)

Xie, L.; Xia, X. J.; Zhou, Y. F.; Wen, Y.; Sun, W. F.; Shi, L. X.

2011-02-01

In this article, a novel pixel readout circuit using a switched-capacitor integrator mode background suppression technique is presented for long wavelength infrared focal plane arrays. This circuit can improve dynamic range and signal-to-noise ratio by suppressing the large background current during integration. Compared with other background suppression techniques, the new background suppression technique is less sensitive to the process mismatch and has no additional shot noise. The proposed circuit is theoretically analysed and simulated while taking into account the non-ideal characteristics. The result shows that the background suppression non-uniformity is ultra-low even for a large process mismatch. The background suppression non-uniformity of the proposed circuit can also remain very small with technology scaling.

A math model for high velocity sensoring with a focal plane shuttered camera.

NASA Technical Reports Server (NTRS)

Morgan, P.

1971-01-01

A new mathematical model is presented which describes the image produced by a focal plane shutter-equipped camera. The model is based upon the well-known collinearity condition equations and incorporates both the translational and rotational motion of the camera during the exposure interval. The first differentials of the model with respect to exposure interval, delta t, yield the general matrix expressions for image velocities which may be simplified to known cases. The exposure interval, delta t, may be replaced under certain circumstances with a function incorporating blind velocity and image position if desired. The model is tested using simulated Lunar Orbiter data and found to be computationally stable as well as providing excellent results, provided that some external information is available on the velocity parameters.

Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng.

PubMed

Zhang, Xu; Li, Shanshan; Sun, Lin; Ji, Li; Zhu, Jingjing; Fan, Yuying; Tai, Guihua; Zhou, Yifa

2012-06-20

In this paper, we further analysed the structure of a type I rhamnogalacturonan (RG-I) pectin (WGPA-2-RG) fractionated from ginseng polysaccharides. Methylation and periodate oxidation analyses showed that WGPA-2-RG has a backbone consisting of alternating rhamnose (Rha) and galacturonic acid (GalA) residues and side chains consisting of type II arabinogalactan (AG-II). Partial acidic hydrolysis for 6h completely removed arabinose (Ara), partial galactose (Gal), but little GalA and Rha. During partial hydrolysis, the molecular weight of WGPA-2-RG decreased smoothly, suggesting that the Ara and cleavable Gal residues exist on the surface of the molecule, while GalA and Rha residues exist in the core of the molecule. The bioactivity assay showed that the arabinogalactan side chains of WGPA-2-RG are essential structures for stimulating NO secretion and lymphocyte proliferation. However, removal of the Ara and Gal residues through hydrolysis did not appreciably affect the ability of WGPA-2-RG to enhance macrophage phagocytosis. Copyright © 2012 Elsevier Ltd. All rights reserved.

Identification and Quantification of Microplastics in Wastewater Using Focal Plane Array-Based Reflectance Micro-FT-IR Imaging.

PubMed

Tagg, Alexander S; Sapp, Melanie; Harrison, Jesse P; Ojeda, Jesús J

2015-06-16

Microplastics (<5 mm) have been documented in environmental samples on a global scale. While these pollutants may enter aquatic environments via wastewater treatment facilities, the abundance of microplastics in these matrices has not been investigated. Although efficient methods for the analysis of microplastics in sediment samples and marine organisms have been published, no methods have been developed for detecting these pollutants within organic-rich wastewater samples. In addition, there is no standardized method for analyzing microplastics isolated from environmental samples. In many cases, part of the identification protocol relies on visual selection before analysis, which is open to bias. In order to address this, a new method for the analysis of microplastics in wastewater was developed. A pretreatment step using 30% hydrogen peroxide (H2O2) was employed to remove biogenic material, and focal plane array (FPA)-based reflectance micro-Fourier-transform (FT-IR) imaging was shown to successfully image and identify different microplastic types (polyethylene, polypropylene, nylon-6, polyvinyl chloride, polystyrene). Microplastic-spiked wastewater samples were used to validate the methodology, resulting in a robust protocol which was nonselective and reproducible (the overall success identification rate was 98.33%). The use of FPA-based micro-FT-IR spectroscopy also provides a considerable reduction in analysis time compared with previous methods, since samples that could take several days to be mapped using a single-element detector can now be imaged in less than 9 h (circular filter with a diameter of 47 mm). This method for identifying and quantifying microplastics in wastewater is likely to provide an essential tool for further research into the pathways by which microplastics enter the environment.

Burst noise in the HAWAII-1RG multiplexer

NASA Astrophysics Data System (ADS)

Bacon, Candice M.; McMurtry, Craig W.; Pipher, Judith L.; Forrest, William J.; Garnett, James D.

2005-08-01

Burst noise (also known as popcorn noise and random telegraph signal/noise) is a phenomenon that is understood to be a result of defects in the vicinity of a p-n junction. It is characterized by rapid level shifts in both positive and negative directions and can have varying magnitudes. This noise has been seen in both HAWAII-1RG and HAWAII-2RG multiplexers and is under investigation. We have done extensive burst noise testing on a HAWAII-1RG multiplexer, where we have determined a significant percentage of pixels exhibit the phenomenon. In addition, the prevalence of small magnitude transitions make sensitivity of detection the main limiting factor. Since this is a noise source for the HAWAII-1RG multiplexer, its elimination would make the HAWAII-1RG and the HAWAII-2RG even lower noise multiplexers.

Compact Focal Plane Assembly for Planetary Science

NASA Technical Reports Server (NTRS)

Brown, Ari; Aslam, Shahid; Huang, Wei-Chung; Steptoe-Jackson, Rosalind

2013-01-01

A compact radiometric focal plane assembly (FPA) has been designed in which the filters are individually co-registered over compact thermopile pixels. This allows for construction of an ultralightweight and compact radiometric instrument. The FPA also incorporates micromachined baffles in order to mitigate crosstalk and low-pass filter windows in order to eliminate high-frequency radiation. Compact metal mesh bandpass filters were fabricated for the far infrared (FIR) spectral range (17 to 100 microns), a game-changing technology for future planetary FIR instruments. This fabrication approach allows the dimensions of individual metal mesh filters to be tailored with better than 10- micron precision. In contrast, conventional compact filters employed in recent missions and in near-term instruments consist of large filter sheets manually cut into much smaller pieces, which is a much less precise and much more labor-intensive, expensive, and difficult process. Filter performance was validated by integrating them with thermopile arrays. Demonstration of the FPA will require the integration of two technologies. The first technology is compact, lightweight, robust against cryogenic thermal cycling, and radiation-hard micromachined bandpass filters. They consist of a copper mesh supported on a deep reactive ion-etched silicon frame. This design architecture is advantageous when constructing a lightweight and compact instrument because (1) the frame acts like a jig and facilitates filter integration with the FPA, (2) the frame can be designed so as to maximize the FPA field of view, (3) the frame can be simultaneously used as a baffle for mitigating crosstalk, and (4) micron-scale alignment features can be patterned so as to permit high-precision filter stacking and, consequently, increase the filter bandwidth and sharpen the out-of-band rolloff. The second technology consists of leveraging, from another project, compact and lightweight Bi0.87Sb0.13/Sb arrayed thermopiles

Far-infrared BRDFs and reflectance spectra of candidate SOFIA telescope, cavity, and focal-plane instrument surfaces

NASA Astrophysics Data System (ADS)

Meyer, Allan W.; Smith, Sheldon M.; Koerber, Christopher T.

2000-06-01

The far-infrared reflectance and scattering properties of telescope surfaces, surrounding cavity walls, and surfaces within focal-plane instruments can be significant contributors to background noise. Radiation from sources well off-axis, such as the earth, moon or aircraft engines may be multiply scattered by the cavity walls and/or surface facets of a complex telescope structure. The Non-Specular Reflectometer at NASA Ames Research Center was reactivated and upgraded, and used to measure reflectance and Bi- directional Reflectance Distribution Functions for samples of planned telescope system structural materials and associated surface treatments.

Nuclease-free Adeno-Associated Virus-Mediated Il2rg Gene Editing in X-SCID Mice.

PubMed

Hiramoto, Takafumi; Li, Li B; Funk, Sarah E; Hirata, Roli K; Russell, David W

2018-05-02

X-linked severe combined immunodeficiency (X-SCID) has been successfully treated by hematopoietic stem cell (HSC) transduction with retroviral vectors expressing the interleukin-2 receptor subunit gamma gene (IL2RG), but several patients developed malignancies due to vector integration near cellular oncogenes. This adverse side effect could in principle be avoided by accurate IL2RG gene editing with a vector that does not contain a functional promoter or IL2RG gene. Here, we show that adeno-associated virus (AAV) gene editing vectors can insert a partial Il2rg cDNA at the endogenous Il2rg locus in X-SCID murine bone marrow cells and that these ex vivo-edited cells repopulate transplant recipients and produce CD4 + and CD8 + T cells. Circulating, edited lymphocytes increased over time and appeared in secondary transplant recipients, demonstrating successful editing in long-term repopulating cells. Random vector integration events were nearly undetectable, and malignant transformation of the transplanted cells was not observed. Similar editing frequencies were observed in human hematopoietic cells. Our results demonstrate that therapeutically relevant HSC gene editing can be achieved by AAV vectors in the absence of site-specific nucleases and suggest that this may be a safe and effective therapy for hematopoietic diseases where in vivo selection can increase edited cell numbers. Copyright © 2018 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Focal-Plane Sensing-Processing: A Power-Efficient Approach for the Implementation of Privacy-Aware Networked Visual Sensors

PubMed Central

Fernández-Berni, Jorge; Carmona-Galán, Ricardo; del Río, Rocío; Kleihorst, Richard; Philips, Wilfried; Rodríguez-Vázquez, Ángel

2014-01-01

The capture, processing and distribution of visual information is one of the major challenges for the paradigm of the Internet of Things. Privacy emerges as a fundamental barrier to overcome. The idea of networked image sensors pervasively collecting data generates social rejection in the face of sensitive information being tampered by hackers or misused by legitimate users. Power consumption also constitutes a crucial aspect. Images contain a massive amount of data to be processed under strict timing requirements, demanding high-performance vision systems. In this paper, we describe a hardware-based strategy to concurrently address these two key issues. By conveying processing capabilities to the focal plane in addition to sensing, we can implement privacy protection measures just at the point where sensitive data are generated. Furthermore, such measures can be tailored for efficiently reducing the computational load of subsequent processing stages. As a proof of concept, a full-custom QVGA vision sensor chip is presented. It incorporates a mixed-signal focal-plane sensing-processing array providing programmable pixelation of multiple image regions in parallel. In addition to this functionality, the sensor exploits reconfigurability to implement other processing primitives, namely block-wise dynamic range adaptation, integral image computation and multi-resolution filtering. The proposed circuitry is also suitable to build a granular space, becoming the raw material for subsequent feature extraction and recognition of categorized objects. PMID:25195849

Focal-plane sensing-processing: a power-efficient approach for the implementation of privacy-aware networked visual sensors.

PubMed

Fernández-Berni, Jorge; Carmona-Galán, Ricardo; del Río, Rocío; Kleihorst, Richard; Philips, Wilfried; Rodríguez-Vázquez, Ángel

2014-08-19

The capture, processing and distribution of visual information is one of the major challenges for the paradigm of the Internet of Things. Privacy emerges as a fundamental barrier to overcome. The idea of networked image sensors pervasively collecting data generates social rejection in the face of sensitive information being tampered by hackers or misused by legitimate users. Power consumption also constitutes a crucial aspect. Images contain a massive amount of data to be processed under strict timing requirements, demanding high-performance vision systems. In this paper, we describe a hardware-based strategy to concurrently address these two key issues. By conveying processing capabilities to the focal plane in addition to sensing, we can implement privacy protection measures just at the point where sensitive data are generated. Furthermore, such measures can be tailored for efficiently reducing the computational load of subsequent processing stages. As a proof of concept, a full-custom QVGA vision sensor chip is presented. It incorporates a mixed-signal focal-plane sensing-processing array providing programmable pixelation of multiple image regions in parallel. In addition to this functionality, the sensor exploits reconfigurability to implement other processing primitives, namely block-wise dynamic range adaptation, integral image computation and multi-resolution filtering. The proposed circuitry is also suitable to build a granular space, becoming the raw material for subsequent feature extraction and recognition of categorized objects.

Shear wave velocity models retrieved using Rg wave dispersion data in shallow crust in some regions of southern Ontario, Canada

NASA Astrophysics Data System (ADS)

Ma, Shutian; Motazedian, Dariush; Corchete, Victor

2013-04-01

Many crucial tasks in seismology, such as locating seismic events and estimating focal mechanisms, need crustal velocity models. The velocity models of shallow structures are particularly important in the simulation of ground motions. In southern Ontario, Canada, many small shallow earthquakes occur, generating high-frequency Rayleigh ( Rg) waves that are sensitive to shallow structures. In this research, the dispersion of Rg waves was used to obtain shear-wave velocities in the top few kilometers of the crust in the Georgian Bay, Sudbury, and Thunder Bay areas of southern Ontario. Several shallow velocity models were obtained based on the dispersion of recorded Rg waves. The Rg waves generated by an m N 3.0 natural earthquake on the northern shore of Georgian Bay were used to obtain velocity models for the area of an earthquake swarm in 2007. The Rg waves generated by a mining induced event in the Sudbury area in 2005 were used to retrieve velocity models between Georgian Bay and the Ottawa River. The Rg waves generated by the largest event in a natural earthquake swarm near Thunder Bay in 2008 were used to obtain a velocity model in that swarm area. The basic feature of all the investigated models is that there is a top low-velocity layer with a thickness of about 0.5 km. The seismic velocities changed mainly within the top 2 km, where small earthquakes often occur.

Optical design of common aperture, common focal plane, multispectral optics for military applications

NASA Astrophysics Data System (ADS)

Thompson, Nicholas Allan

2013-06-01

With recent developments in multispectral detector technology, the interest in common aperture, common focal plane multispectral imaging systems is increasing. Such systems are particularly desirable for military applications, where increased levels of target discrimination and identification are required in cost-effective, rugged, lightweight systems. During the optical design of dual waveband or multispectral systems, the options for material selection are limited. This selection becomes even more restrictive for military applications, where material resilience, thermal properties, and color correction must be considered. We discuss the design challenges that lightweight multispectral common aperture systems present, along with some potential design solutions. Consideration is given to material selection for optimum color correction, as well as material resilience and thermal correction. This discussion is supported using design examples currently in development at Qioptiq.

Visualization of Subsurface Defects in Composites using a Focal Plane Array Infrared Camera

NASA Technical Reports Server (NTRS)

Plotnikov, Yuri A.; Winfree, William P.

1999-01-01

A technique for enhanced defect visualization in composites via transient thermography is presented in this paper. The effort targets automated defect map construction for multiple defects located in the observed area. Experimental data were collected on composite panels of different thickness with square inclusions and flat bottom holes of different depth and orientation. The time evolution of the thermal response and spatial thermal profiles are analyzed. The pattern generated by carbon fibers and the vignetting effect of the focal plane array camera make defect visualization difficult. An improvement of the defect visibility is made by the pulse phase technique and the spatial background treatment. The relationship between a size of a defect and its reconstructed image is analyzed as well. The image processing technique for noise reduction is discussed.

[Effect of ginsenoside Rg3 on Pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1].

PubMed

Jian, Jie; Hu, Zhi-Fang; Huang, Yuan

2009-05-01

Ginsenoside Rg3 is a traditional Chinese medicine monomer which possesses anticancer effects. This study was to investigate the effects of ginsenoside Rg3 on Pim-3 and phosphorylated Bad (pBad) proteins, pBad (Ser112) and pBad (Ser136) in human pancreatic cancer cell line PANC-1. PANC-1 cells were exposed to 10, 20, 40 and 80 micromol/L ginsenoside Rg3 for 24 h. A short hairpin RNA (shRNA) of Pim-3 was cloned and inserted into a eukaryotic expression vector pSilencer 3.1-H1 Neo to construct pSilencer 3.1-H1 Neo-Pim-3. pSilencer 3.1-H1 Neo-Pim-3 was then transfected into PANC-1 cells. Cell proliferation was measured by MTT assay; cell apoptosis was observed under an invert microscope and measured by flow cytometry with Annexin V/PI staining; protein expressions of Pim-3, Bad, pBad (Ser112) and pBad (Ser136) were measured by Western blot. The inhibitory rates of 10, 20, 40 and 80 micromol/L ginsenoside Rg3 on PANC-1 cells were 20.2%, 33.4%, 52.8% and 65.3%, respectively. Typical morphological changes in apoptosis were induced by ginsenoside Rg3. The apoptotic rate of PANC-1 cells was significantly higher in the ginsenoside Rg3 treatment group (80 micromol/L) than in the control group (12.2% vs. 3.3%, P<0.05). Ginsenoside Rg3 had no influence on the total Bad protein expression, but decreased both Pim-3 and pBad (Ser112) expressions in a dose-dependent manner. pBad (Ser136) was not expressed in PANC-1 cells. Compared with the control group, the percentages of early and total apoptotic cells were significantly increased in PANC-1 cells transfected with pim-3-shRNA [(11.5+/-3.7)% vs. (5.8+/-2.2)%,P<0.01;(20.8+/-2.6)% vs.(13.0+/-4.1)%,P<0.05], while the expressions of pim-3 and pBad (Ser112) were both decreased. The anti-tumor effect of ginsenoside Rg3 may be associated with the decrease of Pim-3 and pBad (Ser112).

Automated optical testing of LWIR objective lenses using focal plane array sensors

NASA Astrophysics Data System (ADS)

Winters, Daniel; Erichsen, Patrik; Domagalski, Christian; Peter, Frank; Heinisch, Josef; Dumitrescu, Eugen

2012-10-01

The image quality of today's state-of-the-art IR objective lenses is constantly improving while at the same time the market for thermography and vision grows strongly. Because of increasing demands on the quality of IR optics and increasing production volumes, the standards for image quality testing increase and tests need to be performed in shorter time. Most high-precision MTF testing equipment for the IR spectral bands in use today relies on the scanning slit method that scans a 1D detector over a pattern in the image generated by the lens under test, followed by image analysis to extract performance parameters. The disadvantages of this approach are that it is relatively slow, it requires highly trained operators for aligning the sample and the number of parameters that can be extracted is limited. In this paper we present lessons learned from the R and D process on using focal plane array (FPA) sensors for testing of long-wave IR (LWIR, 8-12 m) optics. Factors that need to be taken into account when switching from scanning slit to FPAs are e.g.: the thermal background from the environment, the low scene contrast in the LWIR, the need for advanced image processing algorithms to pre-process camera images for analysis and camera artifacts. Finally, we discuss 2 measurement systems for LWIR lens characterization that we recently developed with different target applications: 1) A fully automated system suitable for production testing and metrology that uses uncooled microbolometer cameras to automatically measure MTF (on-axis and at several o-axis positions) and parameters like EFL, FFL, autofocus curves, image plane tilt, etc. for LWIR objectives with an EFL between 1 and 12mm. The measurement cycle time for one sample is typically between 6 and 8s. 2) A high-precision research-grade system using again an uncooled LWIR camera as detector, that is very simple to align and operate. A wide range of lens parameters (MTF, EFL, astigmatism, distortion, etc.) can be

Radiometric characterization of type-II InAs/GaSb superlattice (t2sl) midwave infrared photodetectors and focal plane arrays

NASA Astrophysics Data System (ADS)

Nghiem, Jean; Giard, E.; Delmas, M.; Rodriguez, J. B.; Christol, P.; Caes, M.; Martijn, H.; Costard, E.; Ribet-Mohamed, I.

2017-09-01

In recent years, Type-II InAs/GaSb superlattice (T2SL) has emerged as a new material technology suitable for high performance infrared (IR) detectors operating from Near InfraRed (NIR, 2-3μm) to Very Long Wavelength InfraRed (LWIR, λ > 15μm) wavelength domains. To compare their performances with well-established IR technologies such as MCT, InSb or QWIP cooled detectors, specific electrical and radiometric characterizations are needed: dark current, spectral response, quantum efficiency, temporal and spatial noises, stability… In this paper, we first present quantum efficiency measurements performed on T2SL MWIR (3-5μm) photodiodes and on one focal plane array (320x256 pixels with 30μm pitch, realized in the scope of a french collaboration ). Different T2SL structures (InAs-rich versus GaSb-rich) with the same cutoff wavelength (λc= 5μm at 80K) were studied. Results are analysed in term of carrier diffusion length in order to define the optimum thickness and type of doping of the absorbing zone. We then focus on the stability over time of a commercial T2SL FPA (320x256 pixels with 30μm pitch), measuring the commonly used residual fixed pattern noise (RFPN) figure of merit. Results are excellent, with a very stable behaviour over more than 3 weeks, and less than 10 flickering pixels, possibly giving access to long-term stability of IR absolute calibration.

CCD TV focal plane guider development and comparison to SIRTF applications

NASA Technical Reports Server (NTRS)

Rank, David M.

1989-01-01

It is expected that the SIRTF payload will use a CCD TV focal plane fine guidance sensor to provide acquisition of sources and tracking stability of the telescope. Work has been done to develop CCD TV cameras and guiders at Lick Observatory for several years and have produced state of the art CCD TV systems for internal use. NASA decided to provide additional support so that the limits of this technology could be established and a comparison between SIRTF requirements and practical systems could be put on a more quantitative basis. The results of work carried out at Lick Observatory which was designed to characterize present CCD autoguiding technology and relate it to SIRTF applications is presented. Two different design types of CCD cameras were constructed using virtual phase and burred channel CCD sensors. A simple autoguider was built and used on the KAO, Mt. Lemon and Mt. Hamilton telescopes. A video image processing system was also constructed in order to characterize the performance of the auto guider and CCD cameras.

Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2 amplified and TP53 wild-type glioblastomas

PubMed Central

Verreault, Maite; Schmitt, Charlotte; Goldwirt, Lauriane; Pelton, Kristine; Haidar, Samer; Levasseur, Camille; Guehennec, Jeremy; Knoff, David; Labussiere, Marianne; Marie, Yannick; Ligon, Azra H.; Mokhtari, Karima; Hoang-Xuan, Khe; Sanson, Marc; Alexander, Brian M; Wen, Patrick Y.; Delattre, Jean-Yves; Ligon, Keith L.; Idbaih, Ahmed

2016-01-01

Rationale p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most efficacious in patients with TP53 wild-type and MDM2-amplified cancers. However, this biomarker hypothesis has not been tested in patients or patient-derived models for GBM. Methods We performed a preclinical evaluation of RG7112 MDM2 inhibitor, across a panel of 36 patient-derived GBM cell lines (PDCLs), each genetically characterized according to their P53 pathway status. We then performed a pharmacokinetic (PK) profiling of RG7112 distribution in mice and evaluated the therapeutic activity of RG7112 in orthotopic and subcutaneous GBM models. Results MDM2-amplified PDCLs were 44 times more sensitive than TP53 mutated lines that showed complete resistance at therapeutically attainable concentrations (avg. IC50 of 0.52 μM vs 21.9 μM). MDM4 amplified PDCLs were highly sensitive but showed intermediate response (avg. IC50 of 1.2 μM), whereas response was heterogeneous in TP53 wild-type PDCLs with normal MDM2/4 levels (avg. IC50 of 7.7 μM). In MDM2-amplified lines, RG7112 restored p53 activity inducing robust p21 expression and apoptosis. PK profiling of RG7112-treated PDCL intracranial xenografts demonstrated that the compound significantly crosses the blood-brain and the blood-tumor barriers. Most importantly, treatment of MDM2-amplified/TP53 wild-type PDCL-derived model (subcutaneous and orthotopic) reduced tumor growth, was cytotoxic, and significantly increased survival. Conclusion These data strongly support development of MDM2 inhibitors for clinical testing in MDM2-amplified GBM patients. Moreover, significant efficacy in a subset of non-MDM2 amplified models suggests that additional markers of response to MDM2 inhibitors must be identified. PMID:26482041

The Focal Plane Assembly for the Athena X-Ray Integral Field Unit Instrument

NASA Technical Reports Server (NTRS)

Jackson, B. D.; Van Weers, H.; van der Kuur, J.; den Hartog, R.; Akamatsu, H.; Argan, A.; Bandler, S. R.; Barbera, M.; Barret, D.; Bruijn, M. P.;

CCD Centroiding Experiment for Correcting a Distorted Image on the Focal Plane

NASA Astrophysics Data System (ADS)

Yano, Taihei; Araki, Hiroshi; Gouda, Naoteru; Kobayashi, Yukiyasu; Tsujimoto, Takuji; Nakajima, Tadashi; Kawano, Nobuyuki; Tazawa, Seiichi; Yamada, Yoshiyuki; Hanada, Hideo; Asari, Kazuyoshi; Tsuruta, Seiitsu

2006-10-01

JASMINE (Japan Astrometry Satellite Mission for Infrared Exploration) and ILOM (In situ Lunar Orientation Measurement) are space missions that are in progress at the National Astronomical Observatory of Japan. These two projects require a common astrometric technique to obtain precise positions of star images on solid-state detectors in order to accomplish their objectives. In the laboratory, we have carried out measurements of the centroid of artificial star images on a CCD array in order to investigate the precision of the positions of the stars, using an algorithm for estimating them from photon-weighted means of the stars. In the calibration of the position of a star image at the focal plane, we have also taken into account the lowest order distortion due to optical aberrations, which is proportional to the cube of the distance from the optical axis. Accordingly, we find that the precision of the measurement for the positions of the stars reaches below 1/100 pixel for one measurement.

The Mid-Infrared Instrument for the James Webb Space Telescope, VIII: The MIRI Focal Plane System

NASA Astrophysics Data System (ADS)

Ressler, M. E.; Sukhatme, K. G.; Franklin, B. R.; Mahoney, J. C.; Thelen, M. P.; Bouchet, P.; Colbert, J. W.; Cracraft, Misty; Dicken, D.; Gastaud, R.; Goodson, G. B.; Eccleston, Paul; Moreau, V.; Rieke, G. H.; Schneider, Analyn

2015-07-01

We describe the layout and unique features of the focal plane system for MIRI. We begin with the detector array and its readout integrated circuit (combining the amplifier unit cells and the multiplexer), the electronics, and the steps by which the data collection is controlled and the output signals are digitized and delivered to the JWST spacecraft electronics system. We then discuss the operation of this MIRI data system, including detector readout patterns, operation of subarrays, and data formats. Finally, we summarize the performance of the system, including remaining anomalies that need to be corrected in the data pipeline.

Thermal Effects on Camera Focal Length in Messenger Star Calibration and Orbital Imaging

NASA Astrophysics Data System (ADS)

Burmeister, S.; Elgner, S.; Preusker, F.; Stark, A.; Oberst, J.

2018-04-01

We analyse images taken by the MErcury Surface, Space ENviorment, GEochemistry, and Ranging (MESSENGER) spacecraft for the camera's thermal response in the harsh thermal environment near Mercury. Specifically, we study thermally induced variations in focal length of the Mercury Dual Imaging System (MDIS). Within the several hundreds of images of star fields, the Wide Angle Camera (WAC) typically captures up to 250 stars in one frame of the panchromatic channel. We measure star positions and relate these to the known star coordinates taken from the Tycho-2 catalogue. We solve for camera pointing, the focal length parameter and two non-symmetrical distortion parameters for each image. Using data from the temperature sensors on the camera focal plane we model a linear focal length function in the form of f(T) = A0 + A1 T. Next, we use images from MESSENGER's orbital mapping mission. We deal with large image blocks, typically used for the production of a high-resolution digital terrain models (DTM). We analyzed images from the combined quadrangles H03 and H07, a selected region, covered by approx. 10,600 images, in which we identified about 83,900 tiepoints. Using bundle block adjustments, we solved for the unknown coordinates of the control points, the pointing of the camera - as well as the camera's focal length. We then fit the above linear function with respect to the focal plane temperature. As a result, we find a complex response of the camera to thermal conditions of the spacecraft. To first order, we see a linear increase by approx. 0.0107 mm per degree temperature for the Narrow-Angle Camera (NAC). This is in agreement with the observed thermal response seen in images of the panchromatic channel of the WAC. Unfortunately, further comparisons of results from the two methods, both of which use different portions of the available image data, are limited. If leaving uncorrected, these effects may pose significant difficulties in the photogrammetric analysis

Modeling of HgCdTe focal plane array spectral inhomogeneities

NASA Astrophysics Data System (ADS)

Mouzali, Salima; Lefebvre, Sidonie; Rommeluère, Sylvain; Ferrec, Yann; Primot, Jérôme

2015-06-01

Infrared focal plane arrays (IRFPA) are widely used to perform high quality measurements such as spectrum acquisition at high rate, ballistic missile defense, gas detection, and hyperspectral imaging. For these applications, the fixed pattern noise represents one of the major limiting factors of the array performance. This sensor imperfection refers to the nonuniformity between pixels, and is partially caused by disparities of the cut-off wavenumbers. In this work, we focus particularly on mercury cadmium telluride (HgCdTe), which is the most important material of IR cooled detector applications. Among the many advantages of this ternary alloy is the tunability of the bandgap energy with Cadmium composition, as well as the high quantum efficiency. In order to predict and understand spectral inhomogeneities of HgCdTe-based IRFPA, we propose a modeling approach based on the description of optical phenomena inside the pixels. The model considers the p-n junctions as a unique absorbent bulk layer, and derives the sensitivity of the global structure to both Cadmium composition and HgCdTe layer thickness. For this purpose, HgCdTe optical and material properties were necessary to be known at low temperature (80K), in our operating conditions. We therefore achieved the calculation of the real part of the refractive index using subtracti

Using a focal-plane array to estimate antenna pointing errors

NASA Technical Reports Server (NTRS)

Zohar, S.; Vilnrotter, V. A.

1991-01-01

The use of extra collecting horns in the focal plane of an antenna as a means of determining the Direction of Arrival (DOA) of the signal impinging on it, provided it is within the antenna beam, is considered. Our analysis yields a relatively simple algorithm to extract the DOA from the horns' outputs. An algorithm which, in effect, measures the thermal noise of the horns' signals and determines its effect on the uncertainty of the extracted DOA parameters is developed. Both algorithms were implemented in software and tested in simulated data. Based on these tests, it is concluded that this is a viable approach to the DOA determination. Though the results obtained are of general applicability, the particular motivation for the present work is their application to the pointing of a mechanically deformed antenna. It is anticipated that the pointing algorithm developed for a deformed antenna could be obtained as a small perturbation of the algorithm developed for an undeformed antenna. In this context, it should be pointed out that, with a deformed antenna, the array of horns and its associated circuitry constitute the main part of the deformation-compensation system. In this case, the pointing system proposed may be viewed as an additional task carried out by the deformation-compensation hardware.

Development of High-Performance eSWIR HgCdTe-Based Focal-Plane Arrays on Silicon Substrates

NASA Astrophysics Data System (ADS)

Park, J. H.; Pepping, J.; Mukhortova, A.; Ketharanathan, S.; Kodama, R.; Zhao, J.; Hansel, D.; Velicu, S.; Aqariden, F.

2016-09-01

We report the development of high-performance and low-cost extended short-wavelength infrared (eSWIR) focal-plane arrays (FPAs) fabricated from molecular beam epitaxial (MBE)-grown HgCdTe on Si-based substrates. High-quality n-type eSWIR HgCdTe (cutoff wavelength ˜2.68 μm at 77 K, electron carrier concentration 5.82 × 1015 cm-3) layers were grown on CdTe/Si substrates by MBE. High degrees of uniformity in composition and thickness were demonstrated over three-inch areas, and low surface defect densities (voids 9.56 × 101 cm-2, micro-defects 1.67 × 103 cm-2) were measured. This material was used to fabricate 320 × 256 format, 30 μm pitch FPAs with a planar device architecture using arsenic implantation to achieve p-type doping. The dark current density of test devices showed good uniformity between 190 K and room temperature, and high-quality eSWIR imaging from hybridized FPAs was obtained with a median dark current density of 2.63 × 10-7 A/cm2 at 193 K with a standard deviation of 1.67 × 10-7 A/cm2.

FOCAL PLANE WAVEFRONT SENSING USING RESIDUAL ADAPTIVE OPTICS SPECKLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Codona, Johanan L.; Kenworthy, Matthew, E-mail: jlcodona@gmail.com

2013-04-20

Optical imperfections, misalignments, aberrations, and even dust can significantly limit sensitivity in high-contrast imaging systems such as coronagraphs. An upstream deformable mirror (DM) in the pupil can be used to correct or compensate for these flaws, either to enhance the Strehl ratio or suppress the residual coronagraphic halo. Measurement of the phase and amplitude of the starlight halo at the science camera is essential for determining the DM shape that compensates for any non-common-path (NCP) wavefront errors. Using DM displacement ripples to create a series of probe and anti-halo speckles in the focal plane has been proposed for space-based coronagraphsmore » and successfully demonstrated in the lab. We present the theory and first on-sky demonstration of a technique to measure the complex halo using the rapidly changing residual atmospheric speckles at the 6.5 m MMT telescope using the Clio mid-IR camera. The AO system's wavefront sensor measurements are used to estimate the residual wavefront, allowing us to approximately compute the rapidly evolving phase and amplitude of speckle halo. When combined with relatively short, synchronized science camera images, the complex speckle estimates can be used to interferometrically analyze the images, leading to an estimate of the static diffraction halo with NCP effects included. In an operational system, this information could be collected continuously and used to iteratively correct quasi-static NCP errors or suppress imperfect coronagraphic halos.« less

Holographic RG flows from Quasi-Topological Gravity

NASA Astrophysics Data System (ADS)

Camara da Silva, U.; Sotkov, G. M.

2013-09-01

We investigate the holographic Renormalization Group (RG) flows and the critical phenomena that take place in the QFT's dual to the d-dimensional cubic Quasi-Topological Gravity coupled to scalar matter. The knowledge of the corresponding flat Domain Walls (DW's) solutions allows us to derive the explicit form of the QFT's β-functions, as well as of the trace anomalies a(l) and c(l), in terms of the matter superpotential. As a consequence we are able to determine the complete set of CFT data characterizing the universality classes of the UV and IR critical points and to follow the particular RG evolution of this data. We further analyse the dependence of the critical properties of such dual QFT's on the values of the Lovelock couplings and on the shape of the superpotential. For odd values of d, the explicit form of the "a and c-central charges" as functions of the running coupling constant, enable us to establish the conditions under which the a&c-Theorems for their decreasing are valid. The restrictions imposed on the massless holographic RG flows by the requirements of the positivity of the energy fluxes are derived. The particular case of quartic Higgs-like superpotential is studied in detail. It provides an example of unitary dual QFT's having few c≠a-critical points representing second or infinite order phase transitions. Depending on the range of the values of the coupling constant they exhibit massive and massless phases, described by a chain of distinct DW's solutions sharing common boundaries. Remember that the definition of the new maximal "h-scale" in the case of negative h<0 is given by fh=L2/(.

An information-theoretic approach to designing the plane spacing for multifocal plane microscopy

PubMed Central

Tahmasbi, Amir; Ram, Sripad; Chao, Jerry; Abraham, Anish V.; Ward, E. Sally; Ober, Raimund J.

2015-01-01

Multifocal plane microscopy (MUM) is a 3D imaging modality which enables the localization and tracking of single molecules at high spatial and temporal resolution by simultaneously imaging distinct focal planes within the sample. MUM overcomes the depth discrimination problem of conventional microscopy and allows high accuracy localization of a single molecule in 3D along the z-axis. An important question in the design of MUM experiments concerns the appropriate number of focal planes and their spacings to achieve the best possible 3D localization accuracy along the z-axis. Ideally, it is desired to obtain a 3D localization accuracy that is uniform over a large depth and has small numerical values, which guarantee that the single molecule is continuously detectable. Here, we address this concern by developing a plane spacing design strategy based on the Fisher information. In particular, we analyze the Fisher information matrix for the 3D localization problem along the z-axis and propose spacing scenarios termed the strong coupling and the weak coupling spacings, which provide appropriate 3D localization accuracies. Using these spacing scenarios, we investigate the detectability of the single molecule along the z-axis and study the effect of changing the number of focal planes on the 3D localization accuracy. We further review a software module we recently introduced, the MUMDesignTool, that helps to design the plane spacings for a MUM setup. PMID:26113764

Improved neural network based scene-adaptive nonuniformity correction method for infrared focal plane arrays.

PubMed

Lai, Rui; Yang, Yin-tang; Zhou, Duan; Li, Yue-jin

2008-08-20

An improved scene-adaptive nonuniformity correction (NUC) algorithm for infrared focal plane arrays (IRFPAs) is proposed. This method simultaneously estimates the infrared detectors' parameters and eliminates the nonuniformity causing fixed pattern noise (FPN) by using a neural network (NN) approach. In the learning process of neuron parameter estimation, the traditional LMS algorithm is substituted with the newly presented variable step size (VSS) normalized least-mean square (NLMS) based adaptive filtering algorithm, which yields faster convergence, smaller misadjustment, and lower computational cost. In addition, a new NN structure is designed to estimate the desired target value, which promotes the calibration precision considerably. The proposed NUC method reaches high correction performance, which is validated by the experimental results quantitatively tested with a simulative testing sequence and a real infrared image sequence.

The focal plane adaptive optics test box of the Observatoire du Mont-Mégantic

NASA Astrophysics Data System (ADS)

Deschênes, William; Brousseau, Denis; Lavigne, Jean-Francois; Thibault, Simon; Véran, Jean-Pierre

2014-08-01

With the upcoming construction of Extremely Large Telescopes, several existing technologies are being pushed beyond their performance limit and it becomes essential to develop and evaluate new alternatives. The "Observatoire du Mont Mégantic" (OMM) hosts a telescope having a 1.6-meter diameter primary. The OMM telescope is known to be an excellent location to develop and test precursor instruments which are then upscaled to larger telescopes (ex. SPIOMM which led to SITELLE at the CFHT). We present a specifically designed focal plane box for the OMM which will allow to evaluate, directly on-sky, the performance of a number of next generation adaptive optics related technologies The system will able us to compare the performance of several new wavefront sensors in contrast with the current standard, the Shack-Hartman wavefront sensor.

The spectral archive of cosmic X-ray sources observed by the Einstein Observatory Focal Plane Crystal Spectrometer

NASA Technical Reports Server (NTRS)

Lum, Kenneth S. K.; Canizares, Claude R.; Clark, George W.; Coyne, Joan M.; Markert, Thomas H.; Saez, Pablo J.; Schattenburg, Mark L.; Winkler, P. F.

1992-01-01

The Einstein Observatory Focal Plane Crystal Spectrometer (FPCS) used the technique of Bragg spectroscopy to study cosmic X-ray sources in the 0.2-3 keV energy range. The high spectral resolving power (E/Delta-E is approximately equal to 100-1000) of this instrument allowed it to resolve closely spaced lines and study the structure of individual features in the spectra of 41 cosmic X-ray sources. An archival summary of the results is presented as a concise record the FPCS observations and a source of information for future analysis by the general astrophysics community. For each observation, the instrument configuration, background rate, X-ray flux or upper limit within the energy band observed, and spectral histograms are given. Examples of the contributions the FPCS observations have made to the understanding of the objects observed are discussed.

Performance quantification of a millimeter-wavelength imaging system based on inexpensive glow-discharge-detector focal-plane array.

PubMed

Shilemay, Moshe; Rozban, Daniel; Levanon, Assaf; Yitzhaky, Yitzhak; Kopeika, Natan S; Yadid-Pecht, Orly; Abramovich, Amir

2013-03-01

Inexpensive millimeter-wavelength (MMW) optical digital imaging raises a challenge of evaluating the imaging performance and image quality because of the large electromagnetic wavelengths and pixel sensor sizes, which are 2 to 3 orders of magnitude larger than those of ordinary thermal or visual imaging systems, and also because of the noisiness of the inexpensive glow discharge detectors that compose the focal-plane array. This study quantifies the performances of this MMW imaging system. Its point-spread function and modulation transfer function were investigated. The experimental results and the analysis indicate that the image quality of this MMW imaging system is limited mostly by the noise, and the blur is dominated by the pixel sensor size. Therefore, the MMW image might be improved by oversampling, given that noise reduction is achieved. Demonstration of MMW image improvement through oversampling is presented.

WD+RG systems as the progenitors of type Ia supernovae

NASA Astrophysics Data System (ADS)

Wang, Bo; Han, Zhan-Wen

2010-03-01

Type Ia supernovae (SNe Ia) play an important role in the study of cosmic evolution, especially in cosmology. There are several progenitor models for SNe Ia proposed in the past years. By considering the effect of accretion disk instability on the evolution of white dwarf (WD) binaries, we performed detailed binary evolution calculations for the WD + red-giant (RG) channel of SNe Ia, in which a carbon-oxygen WD accretes material from a RG star to increase its mass to the Chandrasekhar mass limit. According to these calculations, we mapped out the initial and final parameters for SNe Ia in the orbital period-secondary mass (log Pi - Mi2) plane for various WD masses for this channel. We discussed the influence of the variation of the duty cycle value on the regions for producing SNe Ia. Similar to previous studies, this work also indicates that the long-period dwarf novae offer possible ways for producing SNe Ia. Meanwhile, we find that the surviving companion stars from this channel have a low mass after the SN explosion, which may provide a means for the formation of the population of single low-mass WDs (<0.45 Modot).

Improved Inflammatory Balance of Human Skeletal Muscle during Exercise after Supplementations of the Ginseng-Based Steroid Rg1

PubMed Central

Hou, Chien-Wen; Lee, Shin-Da; Kao, Chung-Lan; Cheng, I-Shiung; Lin, Yu-Nan; Chuang, Sheng-Ju; Chen, Chung-Yu; Ivy, John L.; Huang, Chih-Yang; Kuo, Chia-Hua

2015-01-01

The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Randomized double-blind placebo-controlled crossover trials were performed, separated by a 4-week washout. Healthy young men were randomized into two groups and received capsule containing either 5 mg of Rg1 or Placebo one night and one hour before exercise. Muscle biopsies were conducted at baseline, immediately and 3 h after a standardized 60-min cycle ergometer exercise. While treatment differences in glycogen depletion rate of biopsied quadriceps muscle during exercise did not reach statistical significance, Rg1 supplementations enhanced post-exercise glycogen replenishment and increased citrate synthase activity in the skeletal muscle 3 h after exercise, concurrent with improved meal tolerance during recovery (P<0.05). Rg1 suppressed the exercise-induced increases in thiobarbituric acids reactive substance (TBARS) and reversed the increased TNF-alpha and decreased IL-10 mRNA of quadriceps muscle against the exercise challenge. PGC-1 alpha and GLUT4 mRNAs of exercised muscle were not affected by Rg1. Maximal aerobic capacity (VO2max) was not changed by Rg1. However, cycling time to exhaustion at 80% VO2max increased significantly by ~20% (P<0.05). Conclusion: Our result suggests that Rg1 is an ergogenic component of ginseng, which can minimize unwanted lipid peroxidation of exercised human skeletal muscle, and attenuate pro-inflammatory shift under exercise challenge. PMID:25617625

Improved inflammatory balance of human skeletal muscle during exercise after supplementations of the ginseng-based steroid Rg1.

PubMed

Hou, Chien-Wen; Lee, Shin-Da; Kao, Chung-Lan; Cheng, I-Shiung; Lin, Yu-Nan; Chuang, Sheng-Ju; Chen, Chung-Yu; Ivy, John L; Huang, Chih-Yang; Kuo, Chia-Hua

2015-01-01

The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Randomized double-blind placebo-controlled crossover trials were performed, separated by a 4-week washout. Healthy young men were randomized into two groups and received capsule containing either 5 mg of Rg1 or Placebo one night and one hour before exercise. Muscle biopsies were conducted at baseline, immediately and 3 h after a standardized 60-min cycle ergometer exercise. While treatment differences in glycogen depletion rate of biopsied quadriceps muscle during exercise did not reach statistical significance, Rg1 supplementations enhanced post-exercise glycogen replenishment and increased citrate synthase activity in the skeletal muscle 3 h after exercise, concurrent with improved meal tolerance during recovery (P<0.05). Rg1 suppressed the exercise-induced increases in thiobarbituric acids reactive substance (TBARS) and reversed the increased TNF-alpha and decreased IL-10 mRNA of quadriceps muscle against the exercise challenge. PGC-1 alpha and GLUT4 mRNAs of exercised muscle were not affected by Rg1. Maximal aerobic capacity (VO2max) was not changed by Rg1. However, cycling time to exhaustion at 80% VO2max increased significantly by ~20% (P<0.05). Our result suggests that Rg1 is an ergogenic component of ginseng, which can minimize unwanted lipid peroxidation of exercised human skeletal muscle, and attenuate pro-inflammatory shift under exercise challenge.

A DSP-based readout and online processing system for a new focal-plane polarimeter at AGOR

NASA Astrophysics Data System (ADS)

Hagemann, M.; Bassini, R.; van den Berg, A. M.; Ellinghaus, F.; Frekers, D.; Hannen, V. M.; Häupke, T.; Heyse, J.; Jacobs, E.; Kirsch, M.; Krüsemann, B.; Rakers, S.; Sohlbach, H.; Wörtche, H. J.

1999-11-01

A Focal-Plane Polarimeter (FPP) for the large acceptance Big-Bite Spectrometer (BBS) at AGOR using a novel readout architecture has been commissioned at the KVI Groningen. The instrument is optimized for medium-energy polarized proton scattering near or at 0°. For the handling of the high counting rates at extreme forward angles and for the suppression of small-angle scattering in the graphite analyzer, a high-performance data processing DSP system connecting to the LeCroy FERA and PCOS ECL bus architecture has been made operational and tested successfully. Details of the system and the functions of the various electronic components are described.

Extended focal-plane array development for the International X-ray Observatory

NASA Astrophysics Data System (ADS)

Smith, Stephen J.; Bandler, Simon R.; Beyer, Joern; Chervenak, James A.; Drung, Dietmar; Eckart, Megan E.; Finkbeiner, Fred M.; Kelley, Richard L.; Kilbourne, Caroline A.; Scott Porter, F.; Sadleir, John E.

2009-12-01

We are developing arrays of transition-edge sensors (TES's) for the International X-ray observatory (IXO). The IXO microcalorimeter array will consist of a central 40×40 core of 300 μm pitch pixels with a resolution of 2.5 eV from 0.3-10 keV. To maximize the science return from the mission, an outer extended array is also required. This 52×52 array (2304 elements surrounding the core) of 600 μm pitch pixels increases the field-of-view from 2' to 5.4' with a resolution of 10 eV. However, significantly increasing the number of readout channels is unfavorable due to the increase in mass and power of the readout chain as well as adding complexity at the focal plane. Consequently, we are developing position-sensitive devices which maintain the same plate scale but at a reduced number of readout channels. One option is to use multiple absorber elements with different thermal conductances to a single TES. Position discrimination is achieved from differences in the pulse rise-time. Another new option is to inductively couple several TES's to a single SQUID. Position discrimination can be achieved by using different combinations of coupling polarity, inductive couplings and heat sink conductances. We present first results demonstrating <9 eV across four 500 μm pixels coupled to a single SQUID. A further possibility is to increase the number of channels to be time-division multiplexed in a single column at some expense in resolution. In this paper we discuss experimental results and trade-offs for these extended array options.

Ginsenoside Rg3 improves cardiac mitochondrial population quality: Mimetic exercise training

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Mengwei; Huang, Chenglin; Wang, Cheng

Highlights: •Rg3 is an ergogenic aid. •Rg3 improves mitochondrial antioxidant capacity. •Rg3 regulates mitochondria dynamic remodeling. •Rg3 alone matches some the benefits of aerobic exercise. -- Abstract: Emerging evidence indicates exercise training could mediate mitochondrial quality control through the improvement of mitochondrial dynamics. Ginsenoside Rg3 (Rg3), one of the active ingredients in Panax ginseng, is well known in herbal medicine as a tonic and restorative agent. However, the molecular mechanism underlying the beneficial effects of Rg3 has been elusive. In the present study, we compared the effects of Rg3 administration with aerobic exercise on mitochondrial adaptation in cardiac muscle tissuemore » of Sprague–Dawley (SD) rats. Three groups of SD rats were studied: (1) sedentary control, (2) Rg3-treated and (3) aerobic exercise trained. Both aerobic exercise training and Rg3 supplementation enhanced peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1α) and nuclear factor-E2-related factor 2 (Nrf2) protein levels in cardiac muscle. The activation of PGC-1α led to increased mRNA levels of mitochondrial transcription factor A (Tfam) and nuclear related factor 1(Nrf1), these changes were accompanied by increases in mitochondrial DNA copy number and complex protein levels, while activation of Nrf2 increased levels of phase II detoxifying enzymes, including nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1(NQO1), superoxide dismutase (MnSOD) and catalase. Aerobic exercise also enhanced mitochondrial autophagy pathway activity, including increased conversion of LC3-I to LC3-II and greater expression of beclin1 and autophagy-related protein 7 (ATG7), these effects of aerobic exercise are comparable to that of Rg3. These results demonstrate that Rg3 mimics improved cardiac adaptations to exercise by regulating mitochondria dynamic remodeling and enhancing the quantity and quality of mitochondria.« less

Detectors for the James Webb Space Telescope near-infrared spectrograph

NASA Astrophysics Data System (ADS)

Rauscher, Bernard J.; Figer, Donald F.; Regan, Michael W.; Boeker, Torsten; Garnett, James; Hill, Robert J.; Bagnasco, Giorgio; Balleza, Jesus; Barney, Richard; Bergeron, Louis E.; Brambora, Clifford; Connelly, Joe; Derro, Rebecca; DiPirro, Michael J.; Doria-Warner, Christina; Ericsson, Aprille; Glazer, Stuart D.; Greene, Charles; Hall, Donald N.; Jacobson, Shane; Jakobsen, Peter; Johnson, Eric; Johnson, Scott D.; Krebs, Carolyn; Krebs, Danny J.; Lambros, Scott D.; Likins, Blake; Manthripragada, Sridhar; Martineau, Robert J.; Morse, Ernie C.; Moseley, Samuel H.; Mott, D. Brent; Muench, Theo; Park, Hongwoo; Parker, Susan; Polidan, Elizabeth J.; Rashford, Robert; Shakoorzadeh, Kamdin; Sharma, Rajeev; Strada, Paolo; Waczynski, Augustyn; Wen, Yiting; Wong, Selmer; Yagelowich, John; Zuray, Monica

2004-10-01

The Near-Infrared Spectrograph (NIRSpec) is the James Webb Space Telescope"s primary near-infrared spectrograph. NASA is providing the NIRSpec detector subsystem, which consists of the focal plane array, focal plane electronics, cable harnesses, and software. The focal plane array comprises two closely-butted λco ~ 5 μm Rockwell HAWAII-2RG sensor chip assemblies. After briefly describing the NIRSpec instrument, we summarize some of the driving requirements for the detector subsystem, discuss the baseline architecture (and alternatives), and presents some recent detector test results including a description of a newly identified noise component that we have found in some archival JWST test data. We dub this new noise component, which appears to be similar to classical two-state popcorn noise in many aspects, "popcorn mesa noise." We close with the current status of the detector subsystem development effort.

Detectors for the James Webb Space Telescope Near-Infrared Spectrograph

NASA Technical Reports Server (NTRS)

Rauscher, Bernard J.; Figer, Donald F.; Regan, Michael W.; Boeker, Torsten; Garnett, James; Hill, Robert J.; Bagnasco, Georgio; Balleza, Jesus; Barney, Richard; Bergeron, Louis E.

2004-01-01

The Near-Infrared Spectrograph (NIRSpec) is the James Webb Space Telescope's primary near-infrared spectrograph. NASA is providing the NIRSpec detector subsystem, which consists of the focal plane array, focal plane electronics, cable harnesses, and software. The focal plane array comprises two closely-butted lambda (sub co) approximately 5 micrometer Rockwell HAWAII- 2RG sensor chip assemblies. After briefly describing the NIRSpec instrument, we summarize some of the driving requirements for the detector subsystem, discuss the baseline architecture (and alternatives), and presents some recent detector test results including a description of a newly identified noise component that we have found in some archival JWST test data. We dub this new noise component, which appears to be similar to classical two-state popcorn noise in many aspects, "popcorn mesa noise." We close with the current status of the detector subsystem development effort.

Ginsenoside Rg1 prevents cerebral and cerebellar injury induced by obstructive jaundice in rats via inducing expression of TIPE-2.

PubMed

Zhou, Tingting; Zu, Guo; Zhou, Lu; Che, Ningwei; Guo, Jing; Liang, Zhanhua

2016-01-01

The aim of the study was to analyze the effect of Ginsenoside Rg1 (Rg1) on cerebral and cerebellar injury in experimental obstructive jaundice (OJ). OJ was done by ligature and section of extrahepatic biliary duct. Rg1 was injected intraperitoneally (10 mg kg(-1)d(-1) or 20 mg kg(-1) d(-1)). Comparison of serum total bile salts (TBA), total bilirubin (TBil), direct bilirubin (DBil), TNF-α, IL-6 and IL-1β among groups. Malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined, also apoptosis and mRNA and protein levels of TIPE2 (TNF-α-inducible protein 8-like 2) were tested in cerebrum and cerebellum. Our results showed that Rg1 reduced MDA and apoptosis in cerebrum and cerebellum induced by OJ, also GSH and antioxidant enzyme activity were raised obviously in rats treated with Rg1. Moreover, decreased mRNA and protein levels of TIPE2 in OJ rats and Rg1 could improve the decreased mRNA and protein levels of TIPE2 in OJ rats. In conclusion, Rg1 decreased oxidative stress and apoptosis, also recovered the antioxidant status and mRNA and protein levels of TIPE2 in the cerebrum and cerebellum of OJ rats. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG Cell Cultures

PubMed Central

Jackson, Jonathan P.; Li, Linhou; Chamberlain, Erica D.; Wang, Hongbing

2016-01-01

Over the last decade HepaRG cells have emerged as a promising alternative to primary human hepatocytes (PHH) and have been featured in over 300 research publications. Most of these reports employed freshly differentiated HepaRG cells that require time-consuming culture (∼28 days) for full differentiation. Recently, a cryopreserved, predifferentiated format of HepaRG cells (termed here “cryo-HepaRG”) has emerged as a new model that improves global availability and experimental flexibility; however, it is largely unknown whether HepaRG cells in this format fully retain their hepatic characteristics. Therefore, we systematically investigated the hepatocyte functionality of cryo-HepaRG cultures in context with the range of interindividual variation observed with PHH in both sandwich-culture and suspension formats. These evaluations uncovered a novel adaptation period for the cryo-HepaRG format and demonstrated the impact of extracellular matrix on cryo-HepaRG functionality. Pharmacologically important drug-metabolizing alleles were genotyped in HepaRG cells and poor metabolizer alleles for CYP2D6, CYP2C9, and CYP3A5 were identified and consistent with higher frequency alleles found in individuals of Caucasian decent. We observed liver enzyme inducibility with aryl hydrocarbon receptor, constitutive androstane receptor (CAR), and pregnane X receptor activators comparable to that of sandwich-cultured PHH. Finally, we show for the first time that cryo-HepaRG supports proper CAR cytosolic sequestration and translocation to hepatocyte nuclei in response to phenobarbital treatment. Taken together, these data reveal important considerations for the use of this cell model and demonstrate that cryo-HepaRG are suitable for metabolism and toxicology screening. PMID:27338863

Protective Effect of Ginsenosides Rg1 and Re on Lipopolysaccharide-Induced Sepsis by Competitive Binding to Toll-Like Receptor 4

PubMed Central

Su, Fei; Xue, Yin; Wang, Yuemin; Zhang, Lili; Chen, Wangxue

2015-01-01

We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necrosis factor α, interleukin-1β, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase from lipopolysaccharide (LPS)-stimulated macrophages. Rg1 was found to be distributed both extracellularly and intracellularly but Re was located only extracellularly to compete with LPS for binding to Toll-like receptor 4. Preinjection of Rg1 and Re into rats suppressed LPS-induced increases in body temperature, white blood cell counts, and levels of serum proinflammatory mediators. Preinjection of Rg1 and Re into mice prevented the LPS-induced decreases in total white blood cell counts and neutrophil counts, inhibited excessive expression of multiple proinflammatory mediators, and successfully rescued 100% of the mice from sepsis-associated death. More significantly, when administered after lethal LPS inoculation, Rg1, but not Re, still showed a potent antisepsis effect and protected 90% of the mice from death. The better protection efficacy of Rg1 could result from its intracellular distribution, suggesting that Rg1 may be an ideal antisepsis agent. PMID:26149990

Demonstration of 1024x1024 pixel dual-band QWIP focal plane array

NASA Astrophysics Data System (ADS)

Gunapala, S. D.; Bandara, S. V.; Liu, J. K.; Mumolo, J. M.; Ting, D. Z.; Hill, C. J.; Nguyen, J.; Rafol, S. B.

2010-04-01

QWIPs are well known for their stability, high pixel-pixel uniformity and high pixel operability which are quintessential parameters for large area imaging arrays. In this paper we report the first demonstration of the megapixel-simultaneously-readable and pixel-co-registered dual-band QWIP focal plane array (FPA). The dual-band QWIP device was developed by stacking two multi-quantum-well stacks tuned to absorb two different infrared wavelengths. The full width at half maximum (FWHM) of the mid-wave infrared (MWIR) band extends from 4.4 - 5.1 μm and FWHM of the long-wave infrared (LWIR) band extends from 7.8 - 8.8 μm. Dual-band QWIP detector arrays were hybridized with direct injection 30 μm pixel pitch megapixel dual-band simultaneously readable CMOS read out integrated circuits using the indium bump hybridization technique. The initial dual-band megapixel QWIP FPAs were cooled to 68K operating temperature. The preliminary data taken from the first megapixel QWIP FPA has shown system NE▵T of 27 and 40 mK for MWIR and LWIR bands respectively.

Modulate chopper technique used in pyroelectric uncooled focal plane array thermal imager

NASA Astrophysics Data System (ADS)

He, Yuqing; Jin, Weiqi; Liu, Guangrong; Gao, Zhiyun; Wang, Xia; Wang, Lingxue

2002-09-01

Pyroelectric uncooled focal plane array (FPA) thermal imager has the advantages of low cost, small size, high responsibility and can work under room temperature, so it has great progress in recent years. As a matched technique, the modulate chopper has become one of the key techniques in uncooled FPA thermal imaging system. Now the Archimedes spiral cord chopper technique is mostly used. When it works, the chopper pushing scans the detector's pixel array, thus makes the pixels being exposed continuously. This paper simulates the shape of this kind of chopper, analyses the exposure time of the detector's every pixel, and also analyses the whole detector pixels' exposure sequence. From the analysis we can get the results: the parameter of Archimedes spiral cord, the detector's thermal time constant, the detector's geometrical dimension, the relative position of the detector to the chopper's spiral cord are the system's important parameters, they will affect the chopper's exposure efficiency and uniformity. We should design the chopper's relevant parameter according to the practical request to achieve the chopper's appropriate structure.

New data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer

NASA Astrophysics Data System (ADS)

Tamii, A.; Sakaguchi, H.; Takeda, H.; Yosoi, M.; Akimune, H.; Fujiwara, M.; Ogata, H.; Tanaka, M.; Togawa, H.

1996-10-01

This paper describes a new data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer at the Research Center for Nuclear Physics (RCNP) in Osaka, Japan. Data are acquired by a Creative Electronic Systems (CES) Starburst, which is a CAMAC auxiliary crate controller equipped with a Digital Equipment Corporation (DEC) J11 microprocessor. The data on the Starburst are transferred to a VME single-board computer. A VME reflective memory module broadcasts the data to other systems through a fiber-optic link. A data transfer rate of 2.0 Mbytes/s between VME modules has been achieved by reflective memories. This rate includes the overhead of buffer management. The overall transfer rate, however, is limited by the performance of the Starburst to about 160 Kbytes/s at maximum. In order to further improve the system performance, we developed a new readout module called the Rapid Data Transfer Module (RDTM). RDTM's transfer data from LeCroy PCOS III's or 4298's, and FERA/FERET's directly to CES 8170 High Speed Memories (HSM) in VME crates, the data transfer rate of the RDTM from PCOS III's to the HSM is about 4 Mbytes/s.

Back-focal-plane position detection with extended linear range for photonic force microscopy.

PubMed

Martínez, Ignacio A; Petrov, Dmitri

2012-09-01

In photonic force microscopes, the position detection with high temporal and spatial resolution is usually implemented by a quadrant position detector placed in the back focal plane of a condenser. An objective with high numerical aperture (NA) for the optical trap has also been used to focus a detection beam. In that case the displacement of the probe at a fixed position of the detector produces a unique and linear response only in a restricted region of the probe displacement, usually several hundred nanometers. There are specific experiments where the absolute position of the probe is a relevant measure together with the probe position relative the optical trap focus. In our scheme we introduce the detection beam into the condenser with low NA through a pinhole with tunable size. This combination permits us to create a wide detection spot and to achieve the linear range of several micrometers by the probe position detection without reducing the trapping force.

Small-pixel long wavelength infrared focal plane arrays based on InAs/GaSb Type-II superlattice

NASA Astrophysics Data System (ADS)

Han, Xi; Jiang, Dongwei; Wang, Guowei; Hao, Hongyue; Sun, Yaoyao; Jiang, Zhi; Lv, Yuexi; Guo, Chunyan; Xu, Yingqiang; Niu, Zhichuan

2018-03-01

The paper reports a 640 × 512 long wavelength infrared focal plane arrays (FPAs) with 15 × 15 μm2 pixels pitch based on the type II InAs/GaSb superlattice. Material grown on a 3 in. GaSb substrate exhibits a 50% cutoff wavelength of 10.2 μm across the entire wafer. The peak quantum efficiency of the detector reaches 28% at 9.1 μm without anti-reflecting coating. Maximal resistance-area products of 8.95 Ω·cm2 at 77 K and 24.4 Ω·cm2 at 45 K are achieved in a single element device indicating that the generation-recombination and tunneling mechanisms dominate the device dark current, respectively. The peak Johnson Detectivity reaches 9.66 × 1011 cm Hz1/2/W at 9.1 μm with the bias voltage of 80 mV. In the whole zone, the operability and non-uniformity for the responsivity are 97.74% and 6.41% respectively. The average noise equivalent temperature difference of 31.9 mK at 77 K is achieved with an integration time of 0.5 ms, a 300 K background and f/2 optics.

Laboratory Measurement of the Brighter-fatter Effect in an H2RG Infrared Detector

NASA Astrophysics Data System (ADS)

Plazas, A. A.; Shapiro, C.; Smith, R.; Huff, E.; Rhodes, J.

2018-06-01

The “brighter-fatter” (BF) effect is a phenomenon—originally discovered in charge coupled devices—in which the size of the detector point-spread function (PSF) increases with brightness. We present, for the first time, laboratory measurements demonstrating the existence of the effect in a Hawaii-2RG HgCdTe near-infrared (NIR) detector. We use JPL’s Precision Projector Laboratory, a facility for emulating astronomical observations with UV/VIS/NIR detectors, to project about 17,000 point sources onto the detector to stimulate the effect. After calibrating the detector for nonlinearity with flat-fields, we find evidence that charge is nonlinearly shifted from bright pixels to neighboring pixels during exposures of point sources, consistent with the existence of a BF-type effect. NASAs Wide Field Infrared Survey Telescope (WFIRST) will use similar detectors to measure weak gravitational lensing from the shapes of hundreds of million of galaxies in the NIR. The WFIRST PSF size must be calibrated to ≈0.1% to avoid biased inferences of dark matter and dark energy parameters; therefore further study and calibration of the BF effect in realistic images will be crucial.

The ASTRO-H X-ray Observatory

NASA Astrophysics Data System (ADS)

Takahashi, Tadayuki; Mitsuda, Kazuhisa; Kelley, Richard; Aarts, Henri; Aharonian, Felix; Akamatsu, Hiroki; Akimoto, Fumie; Allen, Steve; Anabuki, Naohisa; Angelini, Lorella; Arnaud, Keith; Asai, Makoto; Audard, Marc; Awaki, Hisamitsu; Azzarello, Philipp; Baluta, Chris; Bamba, Aya; Bando, Nobutaka; Bautz, Mark; Blandford, Roger; Boyce, Kevin; Brown, Greg; Cackett, Ed; Chernyakova, Mara; Coppi, Paolo; Costantini, Elisa; de Plaa, Jelle; den Herder, Jan-Willem; DiPirro, Michael; Done, Chris; Dotani, Tadayasu; Doty, John; Ebisawa, Ken; Eckart, Megan; Enoto, Teruaki; Ezoe, Yuichiro; Fabian, Andrew; Ferrigno, Carlo; Foster, Adam; Fujimoto, Ryuichi; Fukazawa, Yasushi; Funk, Stefan; Furuzawa, Akihiro; Galeazzi, Massimiliano; Gallo, Luigi; Gandhi, Poshak; Gendreau, Keith; Gilmore, Kirk; Haas, Daniel; Haba, Yoshito; Hamaguchi, Kenji; Hatsukade, Isamu; Hayashi, Takayuki; Hayashida, Kiyoshi; Hiraga, Junko; Hirose, Kazuyuki; Hornschemeier, Ann; Hoshino, Akio; Hughes, John; Hwang, Una; Iizuka, Ryo; Inoue, Yoshiyuki; Ishibashi, Kazunori; Ishida, Manabu; Ishimura, Kosei; Ishisaki, Yoshitaka; Ito, Masayuki; Iwata, Naoko; Iyomoto, Naoko; Kaastra, Jelle; Kallman, Timothy; Kamae, Tuneyoshi; Kataoka, Jun; Katsuda, Satoru; Kawahara, Hajime; Kawaharada, Madoka; Kawai, Nobuyuki; Kawasaki, Shigeo; Khangaluyan, Dmitry; Kilbourne, Caroline; Kimura, Masashi; Kinugasa, Kenzo; Kitamoto, Shunji; Kitayama, Tetsu; Kohmura, Takayoshi; Kokubun, Motohide; Kosaka, Tatsuro; Koujelev, Alex; Koyama, Katsuji; Krimm, Hans; Kubota, Aya; Kunieda, Hideyo; LaMassa, Stephanie; Laurent, Philippe; Lebrun, Francois; Leutenegger, Maurice; Limousin, Olivier; Loewenstein, Michael; Long, Knox; Lumb, David; Madejski, Grzegorz; Maeda, Yoshitomo; Makishima, Kazuo; Marchand, Genevieve; Markevitch, Maxim; Matsumoto, Hironori; Matsushita, Kyoko; McCammon, Dan; McNamara, Brian; Miller, Jon; Miller, Eric; Mineshige, Shin; Minesugi, Kenji; Mitsuishi, Ikuyuki; Miyazawa, Takuya; Mizuno, Tsunefumi; Mori, Hideyuki; Mori, Koji; Mukai, Koji; Murakami, Toshio; Murakami, Hiroshi; Mushotzky, Richard; Nagano, Hosei; Nagino, Ryo; Nakagawa, Takao; Nakajima, Hiroshi; Nakamori, Takeshi; Nakazawa, Kazuhiro; Namba, Yoshiharu; Natsukari, Chikara; Nishioka, Yusuke; Nobukawa, Masayoshi; Nomachi, Masaharu; O'Dell, Steve; Odaka, Hirokazu; Ogawa, Hiroyuki; Ogawa, Mina; Ogi, Keiji; Ohashi, Takaya; Ohno, Masanori; Ohta, Masayuki; Okajima, Takashi; Okamoto, Atsushi; Okazaki, Tsuyoshi; Ota, Naomi; Ozaki, Masanobu; Paerels, Fritzs; Paltani, Stéphane; Parmar, Arvind; Petre, Robert; Pohl, Martin; Porter, F. Scott; Ramsey, Brian; Reis, Rubens; Reynolds, Christopher; Russell, Helen; Safi-Harb, Samar; Sakai, Shin-ichiro; Sameshima, Hiroaki; Sanders, Jeremy; Sato, Goro; Sato, Rie; Sato, Yohichi; Sato, Kosuke; Sawada, Makoto; Serlemitsos, Peter; Seta, Hiromi; Shibano, Yasuko; Shida, Maki; Shimada, Takanobu; Shinozaki, Keisuke; Shirron, Peter; Simionescu, Aurora; Simmons, Cynthia; Smith, Randall; Sneiderman, Gary; Soong, Yang; Stawarz, Lukasz; Sugawara, Yasuharu; Sugita, Hiroyuki; Sugita, Satoshi; Szymkowiak, Andrew; Tajima, Hiroyasu; Takahashi, Hiromitsu; Takeda, Shin-ichiro; Takei, Yoh; Tamagawa, Toru; Tamura, Takayuki; Tamura, Keisuke; Tanaka, Takaaki; Tanaka, Yasuo; Tashiro, Makoto; Tawara, Yuzuru; Terada, Yukikatsu; Terashima, Yuichi; Tombesi, Francesco; Tomida, Hiroshi; Tsuboi, Yohko; Tsujimoto, Masahiro; Tsunemi, Hiroshi; Tsuru, Takeshi; Uchida, Hiroyuki; Uchiyama, Yasunobu; Uchiyama, Hideki; Ueda, Yoshihiro; Ueno, Shiro; Uno, Shinichiro; Urry, Meg; Ursino, Eugenio; de Vries, Cor; Wada, Atsushi; Watanabe, Shin; Werner, Norbert; White, Nicholas; Yamada, Takahiro; Yamada, Shinya; Yamaguchi, Hiroya; Yamasaki, Noriko; Yamauchi, Shigeo; Yamauchi, Makoto; Yatsu, Yoichi; Yonetoku, Daisuke; Yoshida, Atsumasa; Yuasa, Takayuki

2012-09-01

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the highenergy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-12 keV with high spectral resolution of ΔE ≦ 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.

Absolute OH Number Density Measurements in Lean Fuel-Air Mixtures Excited by a Repetitively Pulsed Nanosecond Discharge

DTIC Science & Technology

2013-01-01

cross section quartz channel with wall thickness of 1.75 mm. Two plane quartz windows are fused to the ends of the channel at Brewster angle (for ~308...ttp :// ar c. ai aa .o rg | D O I: 1 0. 25 14 /6 .2 01 3- 43 2 4 about 1 J/pulse, softly focused over the flame using a lens with a focal...region with an f=550 mm lens . The LIF signal sampling volume was about 100 mm away from the laser focal point, to avoid transition saturation. The

SWIR HgCdTe avalanche photiode focal plane array performances evaluation

NASA Astrophysics Data System (ADS)

de Borniol, E.; Rothman, J.; Salveti, F.; Feautrier, P.

2017-11-01

One of the main challenges of modern astronomical instruments like adaptive optics (AO) systems or fringe trackers is to deal with the very low photons flux detection scenarios. The typical timescale of atmospheric turbulences being in the range of some tens of milliseconds, infrared wavefront sensors for AO systems needs frame rates higher than 1 KHz leading to integration times lower than 1 ms. This integration time associated with a low irradiance results in a few number of integrated photons per frame per pixel. To preserve the information coming from this weak signal, the focal plane array (FPA) has to present a low read out noise, a high quantum efficiency and a low dark current. Up to now, the output noise of high speed near infrared sensors is limited by the silicon read out circuit noise. The use of HgCdTe avalanche photodiodes with high gain at moderate reverse bias and low excess noise seems then a logical way to reduce the impact of the read noise on images signal to noise ratio. These low irradiance passive imaging applications with integration times in the millisecond range needs low photodiode dark current and low background current. These requirements lead to the choice of the photodiode cut off wavelength. The short wave infrared (SWIR) around 3 μm is a good compromise between the gain that can be obtain for a given APD bias and the background and dark current. The CEA LETI HgCdTe APD technology, and a fine analysis of the gain curve characteristic are presented in [1] and won't be detailed here. The response time of the APD is also a key factor for a high frame rate FPA. This parameter has been evaluated in [2] and the results shows cut off frequencies in the GHz range. In this communication we report the performances of a SWIR APD FPA designed and fabricated by CEA LETI and SOFRADIR for astrophysical applications. This development was made in the frame of RAPID, a 4 years R&D project funded by the French FUI (Fond Unique Interministériel). This

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays.

PubMed

Murayama, Norie; Usui, Takashi; Slawny, Nicky; Chesné, Christophe; Yamazaki, Hiroshi

2015-01-01

Recent guidance/guidelines for industry recommend that cytochrome P450 induction can be assessed using human hepatocyte enzyme activity and/or mRNA levels to evaluate potential drug- drug interactions. To evaluate time-dependent cytochrome P450 induction precisely, induction of CYP1A2, CYP2B6, and CYP3A4 mRNA was confirmed (>2-fold) by the treatment with omeprazole, phenobarbital, and rifampicin, respectively, for 24 or 48 h on day 3 from the start of culture. After 24 h, the fold induction of CYP1A2 with 3.6 and 1.8x10(4) HepaRG cells per well was lower than that for 7.2x10(4) cells. CYP1A2 induction levels at 24 h were higher than those after 48 h. In contrast, higher CYP2B6 inductions were confirmed after 48 h exposure than after 24 h, independent of the number of cells per well. To help reduce the use of human cryopreserved hepatocytes, typical P450-dependent enzyme activities were investigated in human HepaRG cells cultured in commercial hanging-drop plates. Newly designed 96-well hanging-drop plates were capable of maintaining human CYP3A-dependent midazolam hydroxylation activities for up to 4 days using only 10% of the recommended initial 7.2x10(4) cells per well. Favorable HepaRG function using hanging-drop plates was confirmed by detecting 1'- hydroxymidazolam O-glucuronide on day 3, suggesting an improvement over traditional control plates in which this metabolite can be detected for 24-well plates. These results suggest that the catalytic function and/or induction of CYP1A2, CYP2B6, and CYP3A4 can be readily assessed with reduced numbers of starting HepaRG cells cultured in three-dimensional cultures in drops prepared with hanging-drop plates.

Argus: A W-band 16-pixel focal plane array for the Green Bank Telescope

NASA Astrophysics Data System (ADS)

Devaraj, Kiruthika; Church, Sarah; Cleary, Kieran; Frayer, David; Gawande, Rohit; Goldsmith, Paul; Gundersen, Joshua; Harris, Andrew; Kangaslahti, Pekka; Readhead, Tony; Reeves, Rodrigo; Samoska, Lorene; Sieth, Matt; Voll, Patricia

2015-05-01

We are building Argus, a 16-pixel square-packed focal plane array that will cover the 75-115.3 GHz frequency range on the Robert C. Byrd Green Bank Telescope (GBT). The primary research area for Argus is the study of star formation within our Galaxy and nearby galaxies. Argus will map key molecules that trace star formation, including carbon monoxide (CO) and hydrogen cyanide (HCN). An additional key science area is astrochemistry, which will be addressed by observing complex molecules in the interstellar medium, and the study of formation of solar systems, which will be addressed by identifying dense pre-stellar cores and by observing comets in our solar system. Argus has a highly scalable architecture and will be a technology path finder for larger arrays. The array is modular in construction, which will allow easy replacement of malfunctioning and poorly performing components.

320 x 256 Complementary Barrier Infrared Detector Focal Plane Array for Long-Wave Infrared Imaging

NASA Technical Reports Server (NTRS)

Nguyen, Jean; Rafol, Sir B.; Soibel, Alexander; Khoskhlagh, Arezou; Ting, David Z.-Y.; Liu, John K.; Mumolo, Jason M.; Gunapala, Sarath D.

2012-01-01

A 320 x 256 Complementary Barrier Infrared (CBIRD) focal plane array for long-wavelength infrared (LWIR) imaging is reported. The arrays were grown by molecular beam expitaxy (MBE) with a 300 period 1.9 um thick absorber. The mean dark current density of 2.2 x 10-4 A/cm2 was measured at an operating bias of 128 mV with a long wavelength cutoff of 8.8 ?m observed at 50% of the peak. The maximum quantum efficiency was 54% measured at 5.6 ?m. Operating at T = 80K, the array yielded an 81% fill factor with 97% operability. Good imagery with a mean noise equivalent different temperature (NE?T) of 18.6 mK and a mean detectivity of D* = 1.3 x 1011 cm-Hz1/2/W was achieved. The substrate was thinned using mechanical lapping and neither an AR coating nor a passivation layer was applied. This article provides the details of the fabrication process for achieving low-dark current LWIR CBIRD arrays. Discussion for an effective hard mask for excellent pattern transfer is given and appropriate mounting techniques for good thermal contact during the dry etching process is described. The challenges and differences between etching large 200 ?m test diodes and small 28 ?m FPA pixels are given.

RG flows and instantons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gava, Edi

2012-09-24

In these two lectures I discuss RG flow solutions in (1,0) six dimensional supergravity involving SU(2) Yang-Mills instantons. in the conformally flat part of the 6D metric. The solutions interpolate between two (4,0) supersymmetric AdS{sub 3} Multiplication-Sign S{sup 3} backgrounds with different values of AdS{sub 3} and S{sup 3} radii and describe RG flows in the dual 2D SCFT. The flows described are of v.e.v. type, driven by a vacuum expectation value of a (not exactly) marginal operator of dimension 2 in the UV. We give an interpretation of the supergravity solution in terms of the D1/D5 system in typemore » I string theory on K3, whose effective field theory is expected to flow to a (4,0) SCFT in the infrared.« less

Derivation of force field parameters for SnO2-H2O surface systems from plane-wave density functional theory calculations.

PubMed

Bandura, A V; Sofo, J O; Kubicki, J D

2006-04-27

Plane-wave density functional theory (DFT-PW) calculations were performed on bulk SnO2 (cassiterite) and the (100), (110), (001), and (101) surfaces with and without H2O present. A classical interatomic force field has been developed to describe bulk SnO2 and SnO2-H2O surface interactions. Periodic density functional theory calculations using the program VASP (Kresse et al., 1996) and molecular cluster calculations using Gaussian 03 (Frisch et al., 2003) were used to derive the parametrization of the force field. The program GULP (Gale, 1997) was used to optimize parameters to reproduce experimental and ab initio results. The experimental crystal structure and elastic constants of SnO2 are reproduced reasonably well with the force field. Furthermore, surface atom relaxations and structures of adsorbed H2O molecules agree well between the ab initio and force field predictions. H2O addition above that required to form a monolayer results in consistent structures between the DFT-PW and classical force field results as well.

Identification of the focal plane wavefront control system using E-M algorithm

NASA Astrophysics Data System (ADS)

Sun, He; Kasdin, N. Jeremy; Vanderbei, Robert

2017-09-01

In a typical focal plane wavefront control (FPWC) system, such as the adaptive optics system of NASA's WFIRST mission, the efficient controllers and estimators in use are usually model-based. As a result, the modeling accuracy of the system influences the ultimate performance of the control and estimation. Currently, a linear state space model is used and calculated based on lab measurements using Fourier optics. Although the physical model is clearly defined, it is usually biased due to incorrect distance measurements, imperfect diagnoses of the optical aberrations, and our lack of knowledge of the deformable mirrors (actuator gains and influence functions). In this paper, we present a new approach for measuring/estimating the linear state space model of a FPWC system using the expectation-maximization (E-M) algorithm. Simulation and lab results in the Princeton's High Contrast Imaging Lab (HCIL) show that the E-M algorithm can well handle both the amplitude and phase errors and accurately recover the system. Using the recovered state space model, the controller creates dark holes with faster speed. The final accuracy of the model depends on the amount of data used for learning.

A superconducting focal plane array for ultraviolet, optical, and near-infrared astrophysics.

PubMed

Mazin, Benjamin A; Bumble, Bruce; Meeker, Seth R; O'Brien, Kieran; McHugh, Sean; Langman, Eric

2012-01-16

Microwave Kinetic Inductance Detectors, or MKIDs, have proven to be a powerful cryogenic detector technology due to their sensitivity and the ease with which they can be multiplexed into large arrays. A MKID is an energy sensor based on a photon-variable superconducting inductance in a lithographed microresonator, and is capable of functioning as a photon detector across the electromagnetic spectrum as well as a particle detector. Here we describe the first successful effort to create a photon-counting, energy-resolving ultraviolet, optical, and near infrared MKID focal plane array. These new Optical Lumped Element (OLE) MKID arrays have significant advantages over semiconductor detectors like charge coupled devices (CCDs). They can count individual photons with essentially no false counts and determine the energy and arrival time of every photon with good quantum efficiency. Their physical pixel size and maximum count rate is well matched with large telescopes. These capabilities enable powerful new astrophysical instruments usable from the ground and space. MKIDs could eventually supplant semiconductor detectors for most astronomical instrumentation, and will be useful for other disciplines such as quantum optics and biological imaging.

Shared Focal Plane Investigation for Serial Frame Cameras.

DTIC Science & Technology

1980-03-01

capability will be restored. 41. -.. TrABLE 1-1 SYSTEM LEADING P) ARTICULARS Lens Focal Length (inches) Range (ft) Contrast 12 18 24 Coverage 22.1...can be expected that signature bands will be apparent in the imagery. Such bands are at best distracting and at worst hindrances to image interpretation

Prototype Focal-Plane-Array Optoelectronic Image Processor

NASA Technical Reports Server (NTRS)

Fang, Wai-Chi; Shaw, Timothy; Yu, Jeffrey

1995-01-01

Prototype very-large-scale integrated (VLSI) planar array of optoelectronic processing elements combines speed of optical input and output with flexibility of reconfiguration (programmability) of electronic processing medium. Basic concept of processor described in "Optical-Input, Optical-Output Morphological Processor" (NPO-18174). Performs binary operations on binary (black and white) images. Each processing element corresponds to one picture element of image and located at that picture element. Includes input-plane photodetector in form of parasitic phototransistor part of processing circuit. Output of each processing circuit used to modulate one picture element in output-plane liquid-crystal display device. Intended to implement morphological processing algorithms that transform image into set of features suitable for high-level processing; e.g., recognition.

New data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamii, A.; Sakaguchi, H.; Takeda, H.

1996-10-01

This paper describes a new data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer at the Research Center for Nuclear Physics (RCNP) in Osaka, Japan. Data are acquired by a Creative Electronic Systems (CES) Starburst, which is a CAMAC auxiliary crate controller equipped with a Digital Equipment Corporation (DEC) J11 microprocessor., The data on the Starburst are transferred to a VME single-board computer. A VME reflective memory module broadcasts the data to other systems through a fiber-optic link. A data transfer rate of 2.0 Mbytes/s between VME modules has been achieved by reflective memories. This ratemore » includes the overhead of buffer management. The overall transfer rate, however, is limited by the performance of the Starburst to about 160 Kbytes/s at maximum. In order to further improve the system performance, the authors developed a new readout module called the Rapid Data Transfer Module (RDTM). RDTM`s transfer data from LeCroy PCOS III`s or 4298`s, and FERA/FERET`s directly to CES 8170 High Speed Memories (HSM) in VME crates. The data transfer rate of the RDTM from PCOS III`s to the HSM is about 4 Mbytes/s.« less

Alignment of x-ray tube focal spots for spectral measurement.

PubMed

Nishizawa, K; Maekoshi, H; Kamiya, Y; Kobayashi, Y; Ohara, K; Sakuma, S

1982-01-01

A general method to align a diagnostic x-ray machine for x-ray spectrum measurement purpose was theoretically and experimentally investigated by means of the optical alignment of focal pinhole images. Focal pinhole images were obtained by using a multi-pinholed lead plate. the vertical plane, including the central axis and tube axis, was decided upon by observing the symmetry of focal images. the central axis was designated as a line through the center of focus parallel to the target surface lying in the vertical plane. A method to determine the manipulation of the central axis in any direction is presented.

Studies on design of 351  nm focal plane diagnostic system prototype and focusing characteristic of SGII-upgraded facility at half achievable energy performance.

PubMed

Liu, Chong; Ji, Lailin; Yang, Lin; Zhao, Dongfeng; Zhang, Yanfeng; Liu, Dong; Zhu, Baoqiang; Lin, Zunqi

2016-04-01

In order to obtain the intensity distribution of a 351 nm focal spot and smoothing by spectral dispersion (SSD) focal plane profile of a SGII-upgraded facility, a type of off-axis imaging system with three spherical mirrors, suitable for a finite distance source point to be imaged near the diffraction limit has been designed. The quality factor of the image system is 1.6 times of the diffraction limit tested by a 1053 nm point source. Because of the absence of a 351 nm point source, we can use a Collins diffraction imaging integral with respect to λ=351  nm, corresponding to a quality factor that is 3.8 times the diffraction limit at 351 nm. The calibration results show that at least the range of ±10  mrad of view field angle and ±50  mm along the axial direction around the optimum object distance can be satisfied with near diffraction limited image that is consistent with the design value. Using this image system, the No. 2 beam of the SGII-upgraded facility has been tested. The test result of the focal spot of final optics assembly (FOA) at 351 nm indicates that about 80% of energy is encompassed in 14.1 times the diffraction limit, while the output energy of the No. 2 beam is 908 J at 1053 nm. According to convolution theorem, the true value of a 351 nm focal spot of FOA is about 12 times the diffraction limit because of the influence of the quality factor. Further experimental studies indicate that the RMS value along the smoothing direction is less than 15.98% in the SSD spot test experiment. Computer simulations show that the quality factor of the image system used in the experiment has almost no effect on the SSD focal spot test. The image system can remarkably distort the SSD focal spot distribution under the circumstance of the quality factor 15 times worse than the diffraction limit. The distorted image shows a steep slope in the contour of the SSD focal spot along the smoothing direction that otherwise has a relatively flat top region

Characterization of a compact 6-band multifunctional camera based on patterned spectral filters in the focal plane

NASA Astrophysics Data System (ADS)

Torkildsen, H. E.; Hovland, H.; Opsahl, T.; Haavardsholm, T. V.; Nicolas, S.; Skauli, T.

2014-06-01

In some applications of multi- or hyperspectral imaging, it is important to have a compact sensor. The most compact spectral imaging sensors are based on spectral filtering in the focal plane. For hyperspectral imaging, it has been proposed to use a "linearly variable" bandpass filter in the focal plane, combined with scanning of the field of view. As the image of a given object in the scene moves across the field of view, it is observed through parts of the filter with varying center wavelength, and a complete spectrum can be assembled. However if the radiance received from the object varies with viewing angle, or with time, then the reconstructed spectrum will be distorted. We describe a camera design where this hyperspectral functionality is traded for multispectral imaging with better spectral integrity. Spectral distortion is minimized by using a patterned filter with 6 bands arranged close together, so that a scene object is seen by each spectral band in rapid succession and with minimal change in viewing angle. The set of 6 bands is repeated 4 times so that the spectral data can be checked for internal consistency. Still the total extent of the filter in the scan direction is small. Therefore the remainder of the image sensor can be used for conventional imaging with potential for using motion tracking and 3D reconstruction to support the spectral imaging function. We show detailed characterization of the point spread function of the camera, demonstrating the importance of such characterization as a basis for image reconstruction. A simplified image reconstruction based on feature-based image coregistration is shown to yield reasonable results. Elimination of spectral artifacts due to scene motion is demonstrated.

Managing focal fields of vector beams with multiple polarization singularities.

PubMed

Han, Lei; Liu, Sheng; Li, Peng; Zhang, Yi; Cheng, Huachao; Gan, Xuetao; Zhao, Jianlin

2016-11-10

We explore the tight focusing behavior of vector beams with multiple polarization singularities, and analyze the influences of the number, position, and topological charge of the singularities on the focal fields. It is found that the ellipticity of the local polarization states at the focal plane could be determined by the spatial distribution of the polarization singularities of the vector beam. When the spatial location and topological charge of singularities have even-fold rotation symmetry, the transverse fields at the focal plane are locally linearly polarized. Otherwise, the polarization state becomes a locally hybrid one. By appropriately arranging the distribution of the polarization singularities in the vector beam, the polarization distributions of the focal fields could be altered while the intensity maintains unchanged.

Large-Format HgCdTe Dual-Band Long-Wavelength Infrared Focal-Plane Arrays

NASA Astrophysics Data System (ADS)

Smith, E. P. G.; Venzor, G. M.; Gallagher, A. M.; Reddy, M.; Peterson, J. M.; Lofgreen, D. D.; Randolph, J. E.

2011-08-01

Raytheon Vision Systems (RVS) continues to further its capability to deliver state-of-the-art high-performance, large-format, HgCdTe focal-plane arrays (FPAs) for dual-band long-wavelength infrared (L/LWIR) detection. Specific improvements have recently been implemented at RVS in molecular-beam epitaxy (MBE) growth and wafer fabrication and are reported in this paper. The aim of the improvements is to establish producible processes for 512 × 512 30- μm-unit-cell L/LWIR FPAs, which has resulted in: the growth of triple-layer heterojunction (TLHJ) HgCdTe back-to-back photodiode detector designs on 6 cm × 6 cm CdZnTe substrates with 300-K Fourier-transform infrared (FTIR) cutoff wavelength uniformity of ±0.1 μm across the entire wafer; demonstration of detector dark-current performance for the longer-wavelength detector band approaching that of single-color liquid-phase epitaxy (LPE) LWIR detectors; and uniform, high-operability, 512 × 512 30- μm-unit-cell FPA performance in both LWIR bands.

N = 1 Deformations and RG flows of N = 2 SCFTs, part II: non-principal deformations

DOE PAGES

Agarwal, Prarit; Maruyoshi, Kazunobu; Song, Jaewon

2016-12-20

We continue to investigate the N = 1 deformations of four-dimensional N = 2 superconformal field theories (SCFTs) labeled by a nilpotent element of the flavor symmetry [1]. This triggers a renormalization group (RG) flow to an N = 1 SCFT. We systematically analyze all possible deformations of this type for certain classes of N = 2 SCFTs: conformal SQCDs, generalized Argyres-Douglas theories and the E 6 SCFT. We find a number of examples where the amount of supersymmetry gets enhanced to N = 2 at the end point of the RG flow. Most notably, we find that the SU(N)more » and Sp(N) conformal SQCDs can be deformed to flow to the Argyres-Douglas (AD) theories of type (A 1,D 2 N-1) and (A 1,D 2 N) respectively. This RG flow therefore allows us to compute the full superconformal index of the (A 1,D N) class of AD theories. Moreover, we find an infrared duality between N = 1 theories where the fixed point is described by an N = 2 AD theory. We observe that the classes of examples that exhibit supersymmetry enhancement saturate certain bounds for the central charges implied by the associated two-dimensional chiral algebra.« less

N = 1 Deformations and RG flows of N = 2 SCFTs, part II: non-principal deformations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Prarit; Maruyoshi, Kazunobu; Song, Jaewon

We continue to investigate the N = 1 deformations of four-dimensional N = 2 superconformal field theories (SCFTs) labeled by a nilpotent element of the flavor symmetry [1]. This triggers a renormalization group (RG) flow to an N = 1 SCFT. We systematically analyze all possible deformations of this type for certain classes of N = 2 SCFTs: conformal SQCDs, generalized Argyres-Douglas theories and the E 6 SCFT. We find a number of examples where the amount of supersymmetry gets enhanced to N = 2 at the end point of the RG flow. Most notably, we find that the SU(N)more » and Sp(N) conformal SQCDs can be deformed to flow to the Argyres-Douglas (AD) theories of type (A 1,D 2 N-1) and (A 1,D 2 N) respectively. This RG flow therefore allows us to compute the full superconformal index of the (A 1,D N) class of AD theories. Moreover, we find an infrared duality between N = 1 theories where the fixed point is described by an N = 2 AD theory. We observe that the classes of examples that exhibit supersymmetry enhancement saturate certain bounds for the central charges implied by the associated two-dimensional chiral algebra.« less

Temperature Dependence of Raman-Active In-Plane E2g Phonons in Layered Graphene and h-BN Flakes

NASA Astrophysics Data System (ADS)

Li, Xiaoli; Liu, Jian; Ding, Kai; Zhao, Xiaohui; Li, Shuai; Zhou, Wenguang; Liang, Baolai

2018-01-01

Thermal properties of sp2 systems such as graphene and hexagonal boron nitride (h-BN) have attracted significant attention because of both systems being excellent thermal conductors. This research reports micro-Raman measurements on the in-plane E2g optical phonon peaks ( 1580 cm-1 in graphene layers and 1362 cm-1 in h-BN layers) as a function of temperature from - 194 to 200 °C. The h-BN flakes show higher sensitivity to temperature-dependent frequency shifts and broadenings than graphene flakes. Moreover, the thermal effect in the c direction on phonon frequency in h-BN layers is more sensitive than that in graphene layers but on phonon broadening in h-BN layers is similar as that in graphene layers. These results are very useful to understand the thermal properties and related physical mechanisms in h-BN and graphene flakes for applications of thermal devices.

Snapshot linear-Stokes imaging spectropolarimeter using division-of-focal-plane polarimetry and integral field spectroscopy.

PubMed

Mu, Tingkui; Pacheco, Shaun; Chen, Zeyu; Zhang, Chunmin; Liang, Rongguang

2017-02-13

In this paper, the design and experimental demonstration of a snapshot linear-Stokes imaging spectropolarimeter (SLSIS) is presented. The SLSIS, which is based on division-of-focal-plane polarimetry with four parallel linear polarization channels and integral field spectroscopy with numerous slit dispersive paths, has no moving parts and provides video-rate Stokes-vector hyperspectral datacubes. It does not need any scanning in the spectral, spatial or polarization dimension and offers significant advantages of rapid reconstruction without heavy computation during post-processing. The principle and the experimental setup of the SLSIS are described in detail. The image registration, Stokes spectral reconstruction and calibration procedures are included, and the system is validated using measurements of tungsten light and a static scene. The SLSIS's snapshot ability to resolve polarization spectral signatures is demonstrated using measurements of a dynamic scene.

Snapshot linear-Stokes imaging spectropolarimeter using division-of-focal-plane polarimetry and integral field spectroscopy

PubMed Central

Mu, Tingkui; Pacheco, Shaun; Chen, Zeyu; Zhang, Chunmin; Liang, Rongguang

2017-01-01

In this paper, the design and experimental demonstration of a snapshot linear-Stokes imaging spectropolarimeter (SLSIS) is presented. The SLSIS, which is based on division-of-focal-plane polarimetry with four parallel linear polarization channels and integral field spectroscopy with numerous slit dispersive paths, has no moving parts and provides video-rate Stokes-vector hyperspectral datacubes. It does not need any scanning in the spectral, spatial or polarization dimension and offers significant advantages of rapid reconstruction without heavy computation during post-processing. The principle and the experimental setup of the SLSIS are described in detail. The image registration, Stokes spectral reconstruction and calibration procedures are included, and the system is validated using measurements of tungsten light and a static scene. The SLSIS’s snapshot ability to resolve polarization spectral signatures is demonstrated using measurements of a dynamic scene. PMID:28191819

Circuit models applied to the design of a novel uncooled infrared focal plane array structure

NASA Astrophysics Data System (ADS)

Shi, Shali; Chen, Dapeng; Li, Chaobo; Jiao, Binbin; Ou, Yi; Jing, Yupeng; Ye, Tianchun; Guo, Zheying; Zhang, Qingchuan; Wu, Xiaoping

2007-05-01

This paper describes a circuit model applied to the simulation of the thermal response frequency of a novel substrate-free single-layer bi-material cantilever microstructure used as the focal plane array (FPA) in an uncooled opto-mechanical infrared imaging system. In order to obtain a high detection of the IR object, gold (Au) is coated alternately on the silicon nitride (SiNx) cantilevers of the pixels (Shi S et al Sensors and Actuators A at press), whereas the thermal response frequency decreases (Zhao Y 2002 Dissertation University of California, Berkeley). A circuit model for such a cantilever microstructure is proposed to be applied to evaluate the thermal response performance. The pixel's thermal frequency (1/τth) is calculated to be 10 Hz under the optimized design parameters, which is compatible with the response of optical readout systems and human eyes.

Development of Ultra-Low Noise, High Performance III-V Quantum Well Infrared Photodetectors (QWIPs) for Focal Plane Array Staring Image Sensor Systems

DTIC Science & Technology

1993-11-01

Development of Ultra-Low Noise , High Performance III-V Quantum Well Infrared Photodetectors ( QWIPs )I for Focal Plane Array Staring Image Sensor Systems...experimental studies of dark current, photocurrent, noise fig- ures optical absorption, spectral responsivity and detectivity for different types of QWIPs ...the Boltzmann constant, and T is the temperature. S The noise in the QWIPs is mainly due to the random fluctuations of thermally excited carriers. The

Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.

PubMed

Wang, Zi; Hu, Jun-Nan; Yan, Meng-Han; Xing, Jing-Jing; Liu, Wen-Cong; Li, Wei

2017-10-25

Frequent overdose of acetaminophen (APAP) is one of the most common and important incentives of acute hepatotoxicity. Prior to this work, our research group confirmed that black ginseng (Panax ginseng, BG) showed powerful protective effects on APAP-induced ALI. However, it is not clear which kind of individual ginsenoside from BG plays such a liver protection effect. The objective of the current investigation was to evaluate whether ginsenoside Rg5 (G-Rg5) protected against APAP-induced hepatotoxicity and the involved action mechanisms. Mice were administrated with G-Rg5 at two dosages of 10 or 20 mg/kg for 7 consecutive days. After the last treatment, all of the animals that received a single intraperitoneal injection of APAP (250 mg/kg) showed severe liver toxicity after 24 h, and the liver protection effects of G-Rg5 were examined. The results clearly indicated that pretreatment with G-Rg5 remarkably inhibited the production of serum tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) compared with the APAP group. Meanwhile, G-Rg5 decreased the hepatic malondialdehyde (MDA) content, the protein expression levels of 4-hydroxynonenal (4-HNE) and cytochrome P450 2E1 (CYP2E1) in the liver tissues. G-Rg5 decreased APAP caused the hepatic overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Furthermore, analysis of immunohistochemistry and Western blotting also indicated that G-Rg5 pretreatment inhibited activation of apoptotic pathways mainly via increasing the expression of Bcl-2 protein, decreasing the expression of Bax protein, proliferating cell nuclear antigen (PCNA), cytochrome c, caspase-3, caspase-8, and caspase-9. Liver histopathological observation provided further evidence that pretreatment with G-Rg5 could significantly inhibit hepatocyte necrosis, inflammatory cell infiltration, and apoptosis caused by APAP. In conclusion, the present study clearly demonstrates that G-Rg5 exerts a liver protection effect against

Hierarchical Phased Array Antenna Focal Plane for Cosmic Microwave Background Polarization and Sub-mm Observations

NASA Astrophysics Data System (ADS)

Lee, Adrian

We propose to develop planar-antenna-coupled superconducting bolometer arrays for observations at sub-millimeter to millimeter wavelengths. Our pixel architecture features a dual-polarization, log-periodic antenna with a 5:1 bandwidth ratio, followed by a filter bank that divides the total bandwidth into several broad photometric bands. We propose to develop an hierarchical phased array of our basic pixel type that gives optimal mapping speed (sensitivity) over a much broader range of frequencies. The advantage of this combination of an intrinsically broadband pixel with hierarchical phase arraying include a combination of greatly reduced focal-plane mass, higher array sensitivity, and a larger number of spectral bands compared to focal-plane designs using conventional single-color pixels. These advantages have the potential to greatly reduce cost and/or increase performance of NASA missions in the sub-millimeter to millimeter bands. For CMB polarization, a wide frequency range of about 30 to 400 GHz is required to subtract galactic foregrounds. As an example, the multichroic architecture we propose could reduce the focal plane mass of the EPIC-IM CMB polarization mission study concept by a factor of 4, with great savings in required cryocooler performance and therefore cost. We have demonstrated the lens-coupled antenna concept in the POLARBEAR groundbased CMB polarization experiment which is now operating in Chile. That experiment uses a single-band planar antenna that gives excellent beam properties and optical efficiency. POLARBEAR recently succeeded in detecting gravitational lensing B-modes in the CMB polarization. In the laboratory, we have measured two octaves of total bandwidth in the log-periodic sinuous antenna. We have built filter banks of 2, 3, and 7 bands with 4, 6, and 14 bolometers per pixel for two linear polarizations. Pixels of this type are slated to be deployed on the ground in POLARBEAR and SPT-3G and proposed to be used on a balloon by EBEX

Automated alignment of a reconfigurable optical system using focal-plane sensing and Kalman filtering.

PubMed

Fang, Joyce; Savransky, Dmitry

2016-08-01

Automation of alignment tasks can provide improved efficiency and greatly increase the flexibility of an optical system. Current optical systems with automated alignment capabilities are typically designed to include a dedicated wavefront sensor. Here, we demonstrate a self-aligning method for a reconfigurable system using only focal plane images. We define a two lens optical system with 8 degrees of freedom. Images are simulated given misalignment parameters using ZEMAX software. We perform a principal component analysis on the simulated data set to obtain Karhunen-Loève modes, which form the basis set whose weights are the system measurements. A model function, which maps the state to the measurement, is learned using nonlinear least-squares fitting and serves as the measurement function for the nonlinear estimator (extended and unscented Kalman filters) used to calculate control inputs to align the system. We present and discuss simulated and experimental results of the full system in operation.

IMM-H004, A New Coumarin Derivative, Improved Focal Cerebral Ischemia via Blood-Brain Barrier Protection in Rats.

PubMed

Niu, Fei; Song, Xiu-Yun; Hu, Jin-Feng; Zuo, Wei; Kong, Ling-Lei; Wang, Xiao-Feng; Han, Ning; Chen, Nai-Hong

2017-10-01

IMM-H004 (7-hydroxy-5-methoxy-4-methyl-3-[4-methylpiperazin-1-yl]-2H-chromen-2-one) is a novel coumarin derivative that showed better effect in improving global cerebral ischemia in rats. However, the effects and mechanisms in focal cerebral ischemia were not clear. Blood-brain barrier (BBB) protection is a vital strategy for the treatment of cerebral ischemia. This study is to investigate whether IMM-H004 improves brain ischemia injury via BBB protection. Focal brain ischemia model was induced by middle cerebral artery occlusion for 1 hour and reperfusion (MCAO/R) for 24 hours in rats. IMM-H004 (1.5, 3, 6 mg/kg) and edaravone (positive drug, 6 mg/kg) were administered after 5 minutes of occlusion. Neurological score and TTC staining were used to evaluate the effect of IMM-H004. Evans Blue (EB) staining and electron microscopy were used to assess BBB permeability. Western blot, reverse transcription-polymerase chain reaction, and immunohistochemistry were used to detect the expression of BBB structure-related proteins. Compared with the model group, IMM-H004 in the focal brain ischemia model improved neurological function and reduced cerebral infarction size and edema content. IMM-H004 sharply reduced the EB content and alleviated BBB structure. In addition, IMM-H004 increased the level of zonula occludens (ZO-1) and occluding, decreased the level of aquaporin 4 and matrix metalloproteinase 9, either in cortex or in hippocampus. And all of these changed were related to BBB protection. IMM-H004 improved cerebral ischemia injury via BBB protection. For a potential therapy drug of cerebral ischemia, IMM-H004 merits further study. Copyright © 2017. Published by Elsevier Inc.

Focal mechanisms of recent earthquakes in the Southern Korean Peninsula

NASA Astrophysics Data System (ADS)

Park, Jong-Chan; Kim, Woohan; Chung, Tae Woong; Baag, Chang-Eob; Ree, Jin-Han

2007-06-01

We evaluate the stress field in and around the southern Korean Peninsula with focal mechanism solutions, using the data collected from 71 earthquakes (ML = 1.9-5.2) between 1999 and 2004. For this, the hypocentres were relocated and well-constrained fault plane solutions were obtained from the data set of 1270 clear P-wave polarities and 46 SH/P amplitude ratios. The focal mechanism solutions indicate that the prevailing faulting types in South Korea are strike-slip-dominant-oblique-slip faultings with minor reverse-slip component. The maximum principal stresses (σ1) estimated from fault-slip inversion analysis of the focal mechanism solutions show a similar orientation with E-W trend (269° -275°) and low-angle plunge (10° -25°) for all tectonic provinces in South Korea, consistent with the E-W trending maximum horizontal stress (σHmax) of the Amurian microplate reported from in situ stress measurements and earthquake focal mechanisms. The directions of the intermediate (σ2) and minimum (σ3) principal stresses of the Gyeongsang Basin are, however, about 90 deg off from those of the other tectonic provinces on a common σ2-σ3 plane, suggesting a permutation of σ2 and σ3. Our results incorporated with those from the kinematic studies of the Quaternary faults imply that NNW- to NE-striking faults (dextral strike-slip or oblique-slip with a reverse-slip component) are highly likely to generate earthquakes in South Korea.

RG flows and bifurcations

DOE PAGES

Gukov, Sergei

2017-03-29

Interpreting RG flows as dynamical systems in the space of couplings we produce a variety of constraints, global (topological) as well as local. These constraints, in turn, rule out some of the proposed RG flows and also predict new phases and fixed points, surprisingly, even in familiar theories such as model, QED3, or QCD4.

The H.E.S.S. Galactic plane survey

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Tjus, J. Becker; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carrigan, S.; Caroff, S.; Carosi, A.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Colafrancesco, S.; Condon, B.; Conrad, J.; Davids, I. D.; Decock, J.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Emery, G.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Gaté, F.; Giavitto, G.; Giebels, B.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Malyshev, D.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Safi-Harb, S.; Sahakian, V.; Saito, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schandri, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Shiningayamwe, K.; Simoni, R.; Sol, H.; Spanier, F.; Spir-Jacob, M.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Steppa, C.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsirou, M.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zorn, J.; Żywucka, N.

2018-04-01

We present the results of the most comprehensive survey of the Galactic plane in very high-energy (VHE) γ-rays, including a public release of Galactic sky maps, a catalog of VHE sources, and the discovery of 16 new sources of VHE γ-rays. The High Energy Spectroscopic System (H.E.S.S.) Galactic plane survey (HGPS) was a decade-long observation program carried out by the H.E.S.S. I array of Cherenkov telescopes in Namibia from 2004 to 2013. The observations amount to nearly 2700 h of quality-selected data, covering the Galactic plane at longitudes from ℓ = 250° to 65° and latitudes |b|≤ 3°. In addition to the unprecedented spatial coverage, the HGPS also features a relatively high angular resolution (0.08° ≈ 5 arcmin mean point spread function 68% containment radius), sensitivity (≲1.5% Crab flux for point-like sources), and energy range (0.2-100 TeV). We constructed a catalog of VHE γ-ray sources from the HGPS data set with a systematic procedure for both source detection and characterization of morphology and spectrum. We present this likelihood-based method in detail, including the introduction of a model component to account for unresolved, large-scale emission along the Galactic plane. In total, the resulting HGPS catalog contains 78 VHE sources, of which 14 are not reanalyzed here, for example, due to their complex morphology, namely shell-like sources and the Galactic center region. Where possible, we provide a firm identification of the VHE source or plausible associations with sources in other astronomical catalogs. We also studied the characteristics of the VHE sources with source parameter distributions. 16 new sources were previously unknown or unpublished, and we individually discuss their identifications or possible associations. We firmly identified 31 sources as pulsar wind nebulae (PWNe), supernova remnants (SNRs), composite SNRs, or gamma-ray binaries. Among the 47 sources not yet identified, most of them (36) have possible

A Herschel [C ii] Galactic plane survey. II. CO-dark H2 in clouds

NASA Astrophysics Data System (ADS)

Langer, W. D.; Velusamy, T.; Pineda, J. L.; Willacy, K.; Goldsmith, P. F.

2014-01-01

Context. H i and CO large scale surveys of the Milky Way trace the diffuse atomic clouds and the dense shielded regions of molecular hydrogen clouds, respectively. However, until recently, we have not had spectrally resolved C+ surveys in sufficient lines of sight to characterize the ionized and photon dominated components of the interstellar medium, in particular, the H2 gas without CO, referred to as CO-dark H2, in a large sample of interstellar clouds. Aims: We use a sparse Galactic plane survey of the 1.9 THz (158 μm) [C ii] spectral line from the Herschel open time key programme, Galactic Observations of Terahertz C+ (GOT C+), to characterize the H2 gas without CO in a statistically significant sample of interstellar clouds. Methods: We identify individual clouds in the inner Galaxy by fitting the [C ii] and CO isotopologue spectra along each line of sight. We then combine these spectra with those of H i and use them along with excitation models and cloud models of C+ to determine the column densities and fractional mass of CO-dark H2 clouds. Results: We identify1804 narrow velocity [C ii] components corresponding to interstellar clouds in different categories and evolutionary states. About 840 are diffuse molecular clouds with no CO, ~510 are transition clouds containing [C ii] and 12CO, but no 13CO, and the remainder are dense molecular clouds containing 13CO emission. The CO-dark H2 clouds are concentrated between Galactic radii of ~3.5 to 7.5 kpc and the column density of the CO-dark H2 layer varies significantly from cloud to cloud with a global average of 9 × 1020 cm-2. These clouds contain a significant fraction by mass of CO-dark H2, that varies from ~75% for diffuse molecular clouds to ~20% for dense molecular clouds. Conclusions: We find a significant fraction of the warm molecular ISM gas is invisible in H i and CO, but is detected in [C ii]. The fraction of CO-dark H2 is greatest in the diffuse clouds and decreases with increasing total column

Polarimetric performance of a Laue lens gamma-ray CdZnTe focal plane prototype

NASA Astrophysics Data System (ADS)

Curado da Silva, R. M.; Caroli, E.; Stephen, J. B.; Pisa, A.; Auricchio, N.; Del Sordo, S.; Frontera, F.; Honkimäki, V.; Schiavone, F.; Donati, A.; Trindade, A. M. F.; Ventura, G.

2008-10-01

A gamma-ray telescope mission concept [gamma ray imager (GRI)] based on Laue focusing techniques has been proposed in reply to the European Space Agency call for mission ideas within the framework of the next decade planning (Cosmic Vision 2015-2025). In order to optimize the design of a focal plane for this satellite mission, a CdZnTe detector prototype has been tested at the European Synchrotron Radiation Facility under an ~100% polarized gamma-ray beam. The spectroscopic, imaging, and timing performances were studied and in particular its potential as a polarimeter was evaluated. Polarization has been recognized as being a very important observational parameter in high energy astrophysics (>100 keV) and therefore this capability has been specifically included as part of the GRI mission proposal. The prototype detector tested was a 5 mm thick CdZnTe array with an 11×11 active pixel matrix (pixel area of 2.5×2.5 mm2). The detector was irradiated by a monochromatic linearly polarized beam with a spot diameter of about 0.5 mm over the energy range between 150 and 750 keV. Polarimetric Q factors of 0.35 and double event relative detection efficiency of 20% were obtained. Further measurements were performed with a copper Laue monochromator crystal placed between the beam and the detector prototype. In this configuration we have demonstrated that a polarized beam does not change its polarization level and direction after undergoing a small angle (<1°) Laue diffraction inside a crystal.

Relativity-Induced Bonding Pattern Change in Coinage Metal Dimers M2 (M = Cu, Ag, Au, Rg).

PubMed

Li, Wan-Lu; Lu, Jun-Bo; Wang, Zhen-Ling; Hu, Han-Shi; Li, Jun

2018-05-07

The periodic table provides a fundamental protocol for qualitatively classifying and predicting chemical properties based on periodicity. While the periodic law of chemical elements had already been rationalized within the framework of the nonrelativistic description of chemistry with quantum mechanics, this law was later known to be affected significantly by relativity. We here report a systematic theoretical study on the chemical bonding pattern change in the coinage metal dimers (Cu 2 , Ag 2 , Au 2 , Rg 2 ) due to the relativistic effect on the superheavy elements. Unlike the lighter congeners basically demonstrating ns- ns bonding character and a 0 g + ground state, Rg 2 shows unique 6d-6d bonding induced by strong relativity. Because of relativistic spin-orbit (SO) coupling effect in Rg 2 , two nearly degenerate SO states, 0 g + and 2 u , exist as candidate of the ground state. This relativity-induced change of bonding mechanism gives rise to various unique alteration of chemical properties compared with the lighter dimers, including higher intrinsic bond energy, force constant, and nuclear shielding. Our work thus provides a rather simple but clear-cut example, where the chemical bonding picture is significantly changed by relativistic effect, demonstrating the modified periodic law in heavy-element chemistry.

640 x 512 Pixels Long-Wavelength Infrared (LWIR) Quantum-Dot Infrared Photodetector (QDIP) Imaging Focal Plane Array

NASA Technical Reports Server (NTRS)

Gunapala, Sarath D.; Bandara, Sumith V.; Hill, Cory J.; Ting, David Z.; Liu, John K.; Rafol, Sir B.; Blazejewski, Edward R.; Mumolo, Jason M.; Keo, Sam A.; Krishna, Sanjay;

15-micro-m 128 x 128 GaAs/Al(x)Ga(1-x) As Quantum Well Infrared Photodetector Focal Plane Array Camera

NASA Technical Reports Server (NTRS)

Gunapala, Sarath D.; Park, Jin S.; Sarusi, Gabby; Lin, True-Lon; Liu, John K.; Maker, Paul D.; Muller, Richard E.; Shott, Craig A.; Hoelter, Ted

1997-01-01

In this paper, we discuss the development of very sensitive, very long wavelength infrared GaAs/Al(x)Ga(1-x)As quantum well infrared photodetectors (QWIP's) based on bound-to-quasi-bound intersubband transition, fabrication of random reflectors for efficient light coupling, and the demonstration of a 15 micro-m cutoff 128 x 128 focal plane array imaging camera. Excellent imagery, with a noise equivalent differential temperature (N E(delta T)) of 30 mK has been achieved.

Evaluation and display of polarimetric image data using long-wave cooled microgrid focal plane arrays

NASA Astrophysics Data System (ADS)

Bowers, David L.; Boger, James K.; Wellems, L. David; Black, Wiley T.; Ortega, Steve E.; Ratliff, Bradley M.; Fetrow, Matthew P.; Hubbs, John E.; Tyo, J. Scott

2006-05-01

Recent developments for Long Wave InfraRed (LWIR) imaging polarimeters include incorporating a microgrid polarizer array onto the focal plane array (FPA). Inherent advantages over typical polarimeters include packaging and instantaneous acquisition of thermal and polarimetric information. This allows for real time video of thermal and polarimetric products. The microgrid approach has inherent polarization measurement error due to the spatial sampling of a non-uniform scene, residual pixel to pixel variations in the gain corrected responsivity and in the noise equivalent input (NEI), and variations in the pixel to pixel micro-polarizer performance. The Degree of Linear Polarization (DoLP) is highly sensitive to these parameters and is consequently used as a metric to explore instrument sensitivities. Image processing and fusion techniques are used to take advantage of the inherent thermal and polarimetric sensing capability of this FPA, providing additional scene information in real time. Optimal operating conditions are employed to improve FPA uniformity and sensitivity. Data from two DRS Infrared Technologies, L.P. (DRS) microgrid polarizer HgCdTe FPAs are presented. One FPA resides in a liquid nitrogen (LN2) pour filled dewar with a 80°K nominal operating temperature. The other FPA resides in a cryogenic (cryo) dewar with a 60° K nominal operating temperature.

Noise characteristics analysis of short wave infrared InGaAs focal plane arrays

NASA Astrophysics Data System (ADS)

Yu, Chunlei; Li, Xue; Yang, Bo; Huang, Songlei; Shao, Xiumei; Zhang, Yaguang; Gong, Haimei

2017-09-01

The increasing application of InGaAs short wave infrared (SWIR) focal plane arrays (FPAs) in low light level imaging requires ultra-low noise FPAs. This paper presents the theoretical analysis of FPA noise, and point out that both dark current and detector capacitance strongly affect the FPA noise. The impact of dark current and detector capacitance on FPA noise is compared in different situations. In order to obtain low noise performance FPAs, the demand for reducing detector capacitance is higher especially when pixel pitch is smaller, integration time is shorter, and integration capacitance is larger. Several InGaAs FPAs were measured and analyzed, the experiments' results could be well fitted to the calculated results. The study found that the major contributor of FPA noise is coupled noise with shorter integration time. The influence of detector capacitance on FPA noise is more significant than that of dark current. To investigate the effect of detector performance on FPA noise, two kinds of photodiodes with different concentration of the absorption layer were fabricated. The detectors' performance and noise characteristics were measured and analyzed, the results are consistent with that of theoretical analysis.

Polarization and Out-of-Plane Observables in the γ^*NarrowΔ Transition

NASA Astrophysics Data System (ADS)

Kaloskamis, N. I.

1998-10-01

The H(e,e^' p)π^0, H(e,e^' p)π^0 and H(e,e^' π^+)n reactions have been studied at Bates during the past three years. Polarization observables have been measured for the first time in order to extract the Coulomb quadrupole amplitude of the γ^*NarrowΔ transition, by isolating it from that due to background processes. The detection equipment included a focal plane polarimeter (FPP) in the first experiment, and out-of-plane spectrometers (OOPS) in the second. Measurements were made at Q^2=0.127 (GeV/c)^2, invariant masses of W=1170, 1232, 1294 MeV and angles θ_pq^cm of up to 61^o. Data will be presented for the total cross section and the proton recoil polarization (P_n). Combined with sequencial measurements of the space asymmetry (A_LT), they provide clear discrimination among available electroproduction models and do not confirm a recent reportfootnote F. Kalleicher et al., Z. Phys. A359, 201 (1997) of a large Coulomb quadrupole amplitude. Preliminary data of the helicity asymmetry (A_LT^'), measured simultaneously using two OOPS modules, will also be presented.

Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma.

PubMed

Magaña-Maldonado, Roxana; Manoutcharian, Karen; Hernández-Pedro, Norma Y; Rangel-López, Edgar; Pérez-De la Cruz, Verónica; Rodríguez-Balderas, César; Sotelo, Julio; Pineda, Benjamín

2014-02-01

Glioblastoma multiforme is the most frequent primary brain tumor, it has poor prognosis, and it remains refractory to current treatment. The success of temozolomide (TMZ) appears to be limited by the occurrence of chemoresistance. Recently, we report the use of pertussis toxin as adjuvant immunotherapy in a C6 glioma model; showing a decrease in tumoral size, it induced selective cell death in Treg cells, and it elicited less infiltration of tumoral macrophages. Here, we evaluated the cytotoxic effect of pertussis toxin in combination with TMZ for glioma treatment, both in vitro and in vivo RG2 glioma model. We determined cell viability, cell cycle, apoptosis, and autophagy on treated RG2 cells through flow cytometry, immunofluorescence, and Western blot assays. Twenty-eight rats were divided in four groups (n = 7) for each treatment. After intracranial implantation of RG2 cells, animals were treated with TMZ (10 mg/Kg/200 μl of apple juice), PTx (2 μg/200 μl of saline solution), and TMZ + PTx. Animals without treatment were considered as control. We found an induction of apoptosis in around 20 % of RG2 cells, in both single treatments and in their combination. Also, we determined the presence of autophagy vesicles, without any modifications in the cell cycle in the TMZ - PTx-treated groups. The survival analyses showed an increase due to individual treatments; while in the group treated with the combination TMZ - PTx, this effect was enhanced. We show that the concomitant use of pertussis toxin plus TMZ could represent an advantage to improve the glioma treatment.

Performance of Hg1-xCdxTe infrared focal plane array at elevated temperature

NASA Astrophysics Data System (ADS)

Singh, Anand; Pal, Ravinder

2017-04-01

The simulated optical and electrical performance of the infrared HgCdTe focal plane array (FPA) for elevated operation temperature is reported. The depleted absorber layer is explored for equilibrium mode of operation up to 160 K. A resonant cavity is created to improve photon-matter interaction and hence, reduces the required absorption volume. The volume of the active region of HgCdTe detector is reduced by 70% in this manner. Dark current density is decreased without compromising the quantum efficiency. The effect of the reduced band filling effect leading to higher absorption coefficient and more efficient utilization of incident flux is employed. High quantum efficiency is achieved in a thin compositionally graded n+/ν/π/p HgCdTe photo-diode. This architecture helps to minimize the requirement of charge handling capacity in the CMOS read-out integrated circuit (ROIC) as the operation temperature is increased. Quantum efficiency ˜30% or above is shown to be sufficient for Noise Equivalent Temperature Difference (NETD) less than 20 mK with the reported design.

Miniaturized Fourier-plane fiber scanner for OCT endoscopy

NASA Astrophysics Data System (ADS)

Vilches, Sergio; Kretschmer, Simon; Ataman, Çağlar; Zappe, Hans

2017-10-01

A forward-looking endoscopic optical coherence tomography (OCT) probe featuring a Fourier-plane fiber scanner is designed, manufactured and characterized. In contrast to common image-plane fiber scanners, the Fourier-plane scanner is a telecentric arrangement that eliminates vignetting and spatial resolution variations across the image plane. To scan the OCT beam in a spiral pattern, a tubular piezoelectric actuator is used to resonate an optical fiber bearing a collimating GRIN lens at its tip. The free-end of the GRIN lens sits at the back focal plane of an objective lens, such that its rotation replicates the beam angles in the collimated region of a classical telecentric 4f optical system. Such an optical arrangement inherently has a low numerical aperture combined with a relatively large field-of-view, rendering it particularly useful for endoscopic OCT imaging. Furthermore, the optical train of the Fourier-plane scanner is shorter than that of a comparable image-plane scanner by one focal length of the objective lens, significantly shortening the final arrangement. As a result, enclosed within a 3D printed housing of 2.5 mm outer diameter and 15 mm total length, the developed probe is the most compact forward-looking endoscopic OCT imager to date. Due to its compact form factor and compatibility with real-time OCT imaging, the developed probe is also ideal for use in the working channel of flexible endoscopes as a potential optical biopsy tool.

The Mechanical Design of a Kinematic Mount for the Mid Infrared Instrument Focal Plane Module on the James Webb Space Telescope

NASA Technical Reports Server (NTRS)

Thelen, Michael P.; Moore, Donald M.

2009-01-01

The detector assembly for the Mid Infrared Instrument (MIRI) of the James Webb Space Telescope (JWST) is mechanically supported in the Focal Plane Module (FPM) Assembly with an efficient hexapod design. The kinematic mount design allows for precision adjustment of the detector boresight to assembly alignment fiducials and maintains optical alignment requirements during flight conditions of launch and cryogenic operations below 7 Kelvin. This kinematic mounting technique is able to be implemented in a variety of optical-mechanical designs and is capable of micron level adjustment control and stability over wide dynamic and temperature ranges.

Controlling dental enamel-cavity ablation depth with optimized stepping parameters along the focal plane normal using a three axis, numerically controlled picosecond laser.

PubMed

Yuan, Fusong; Lv, Peijun; Wang, Dangxiao; Wang, Lei; Sun, Yuchun; Wang, Yong

2015-02-01

The purpose of this study was to establish a depth-control method in enamel-cavity ablation by optimizing the timing of the focal-plane-normal stepping and the single-step size of a three axis, numerically controlled picosecond laser. Although it has been proposed that picosecond lasers may be used to ablate dental hard tissue, the viability of such a depth-control method in enamel-cavity ablation remains uncertain. Forty-two enamel slices with approximately level surfaces were prepared and subjected to two-dimensional ablation by a picosecond laser. The additive-pulse layer, n, was set to 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70. A three-dimensional microscope was then used to measure the ablation depth, d, to obtain a quantitative function relating n and d. Six enamel slices were then subjected to three dimensional ablation to produce 10 cavities, respectively, with additive-pulse layer and single-step size set to corresponding values. The difference between the theoretical and measured values was calculated for both the cavity depth and the ablation depth of a single step. These were used to determine minimum-difference values for both the additive-pulse layer (n) and single-step size (d). When the additive-pulse layer and the single-step size were set 5 and 45, respectively, the depth error had a minimum of 2.25 μm, and 450 μm deep enamel cavities were produced. When performing three-dimensional ablating of enamel with a picosecond laser, adjusting the timing of the focal-plane-normal stepping and the single-step size allows for the control of ablation-depth error to the order of micrometers.

2-tier in-plane motion correction and out-of-plane motion filtering for contrast-enhanced ultrasound.

PubMed

Ta, Casey N; Eghtedari, Mohammad; Mattrey, Robert F; Kono, Yuko; Kummel, Andrew C

2014-11-01

Contrast-enhanced ultrasound (CEUS) cines of focal liver lesions (FLLs) can be quantitatively analyzed to measure tumor perfusion on a pixel-by-pixel basis for diagnostic indication. However, CEUS cines acquired freehand and during free breathing cause nonuniform in-plane and out-of-plane motion from frame to frame. These motions create fluctuations in the time-intensity curves (TICs), reducing the accuracy of quantitative measurements. Out-of-plane motion cannot be corrected by image registration in 2-dimensional CEUS and degrades the quality of in-plane motion correction (IPMC). A 2-tier IPMC strategy and adaptive out-of-plane motion filter (OPMF) are proposed to provide a stable correction of nonuniform motion to reduce the impact of motion on quantitative analyses. A total of 22 cines of FLLs were imaged with dual B-mode and contrast specific imaging to acquire a 3-minute TIC. B-mode images were analyzed for motion, and the motion correction was applied to both B-mode and contrast images. For IPMC, the main reference frame was automatically selected for each cine, and subreference frames were selected in each respiratory cycle and sequentially registered toward the main reference frame. All other frames were sequentially registered toward the local subreference frame. Four OPMFs were developed and tested: subsample normalized correlation (NC), subsample sum of absolute differences, mean frame NC, and histogram. The frames that were most dissimilar to the OPMF reference frame using 1 of the 4 above criteria in each respiratory cycle were adaptively removed by thresholding against the low-pass filter of the similarity curve. Out-of-plane motion filter was quantitatively evaluated by an out-of-plane motion metric (OPMM) that measured normalized variance in the high-pass filtered TIC within the tumor region-of-interest with low OPMM being the goal. Results for IPMC and OPMF were qualitatively evaluated by 2 blinded observers who ranked the motion in the cines

Statistical Earthquake Focal Mechanism Forecasts

NASA Astrophysics Data System (ADS)

Kagan, Y. Y.; Jackson, D. D.

2013-12-01

The new whole Earth focal mechanism forecast, based on the GCMT catalog, has been created. In the present forecast, the sum of normalized seismic moment tensors within 1000 km radius is calculated and the P- and T-axes for the focal mechanism are evaluated on the basis of the sum. Simultaneously we calculate an average rotation angle between the forecasted mechanism and all the surrounding mechanisms. This average angle shows tectonic complexity of a region and indicates the accuracy of the prediction. The method was originally proposed by Kagan and Jackson (1994, JGR). Recent interest by CSEP and GEM has motivated some improvements, particularly to extend the previous forecast to polar and near-polar regions. The major problem in extending the forecast is the focal mechanism calculation on a spherical surface. In the previous forecast as our average focal mechanism was computed, it was assumed that longitude lines are approximately parallel within 1000 km radius. This is largely accurate in the equatorial and near-equatorial areas. However, when one approaches the 75 degree latitude, the longitude lines are no longer parallel: the bearing (azimuthal) difference at points separated by 1000 km reach about 35 degrees. In most situations a forecast point where we calculate an average focal mechanism is surrounded by earthquakes, so a bias should not be strong due to the difference effect cancellation. But if we move into polar regions, the bearing difference could approach 180 degrees. In a modified program focal mechanisms have been projected on a plane tangent to a sphere at a forecast point. New longitude axes which are parallel in the tangent plane are corrected for the bearing difference. A comparison with the old 75S-75N forecast shows that in equatorial regions the forecasted focal mechanisms are almost the same, and the difference in the forecasted focal mechanisms rotation angle is close to zero. However, though the forecasted focal mechanisms are similar

Focal plane arrays for submillimeter waves using two-dimensional electron gas elements: A grant under the Innovative Research Program

NASA Technical Reports Server (NTRS)

Yngvesson, K. Sigfrid; Lau, Kei-May

1992-01-01

This final report describes a three-year research effort, aimed at developing new types of THz low noise receivers, based on bulk effect ('hot electron') nonlinearities in the Two-Dimensional Electron Gas (2DEG) Medium, and the inclusion of such receivers in focal plane arrays. 2DEG hot electron mixers have been demonstrated at 35 and 94 GHz with three orders of magnitude wider bandwidth than previous hot electron mixers, which use bulk InSb. The 2DEG mixers employ a new mode of operation, which was invented during this program. Only moderate cooling is required for this mode, to temperatures in the range 20-77 K. Based on the results of this research, it is now possible to design a hot electron mixer focal plane array for the THz range, which is anticipated to have a DSB receiver noise temperature of 500-1000K. In our work on this grant, we have found similar results the the Cronin group (resident at the University of Bath, UK). Neither group has so far demonstrated heterodyne detection in this mode, however. We discovered and explored some new effects in the magnetic field mode, and these are described in the report. In particular, detection of 94 GHz and 238 GHz, respectively, by a new effect, 'Shubnikov de Haas detection', was found to be considerably stronger in our materials than the cyclotron resonance detection. All experiments utilized devices with an active 2DEG region of size of the order of 10-40 micrometers long, and 20-200 micrometers wide, formed at the heterojunction between AlGaAs and GaAs. All device fabrication was performed in-house. The materials for the devices were also grown in-house, utilizing OMCVD (Organo Metallic Chemical Vapor Deposition). In the course of this grant, we developed new techniques for growing AlGaAs/GaAs with mobilities equalling the highest values published by any laboratory. We believe that the field of hot electron mixers and detectors will grow substantially in importance in the next few years, partly as a result of

Focal plane arrays for submillimeter waves using two-dimensional electron gas elements: A grant under the Innovative Research Program

NASA Astrophysics Data System (ADS)

Yngvesson, K. Sigfrid; Lau, Kei-May

1992-02-01

This final report describes a three-year research effort, aimed at developing new types of THz low noise receivers, based on bulk effect ('hot electron') nonlinearities in the Two-Dimensional Electron Gas (2DEG) Medium, and the inclusion of such receivers in focal plane arrays. 2DEG hot electron mixers have been demonstrated at 35 and 94 GHz with three orders of magnitude wider bandwidth than previous hot electron mixers, which use bulk InSb. The 2DEG mixers employ a new mode of operation, which was invented during this program. Only moderate cooling is required for this mode, to temperatures in the range 20-77 K. Based on the results of this research, it is now possible to design a hot electron mixer focal plane array for the THz range, which is anticipated to have a DSB receiver noise temperature of 500-1000K. In our work on this grant, we have found similar results the the Cronin group (resident at the University of Bath, UK). Neither group has so far demonstrated heterodyne detection in this mode, however. We discovered and explored some new effects in the magnetic field mode, and these are described in the report. In particular, detection of 94 GHz and 238 GHz, respectively, by a new effect, 'Shubnikov de Haas detection', was found to be considerably stronger in our materials than the cyclotron resonance detection. All experiments utilized devices with an active 2DEG region of size of the order of 10-40 micrometers long, and 20-200 micrometers wide, formed at the heterojunction between AlGaAs and GaAs. All device fabrication was performed in-house. The materials for the devices were also grown in-house, utilizing OMCVD (Organo Metallic Chemical Vapor Deposition). In the course of this grant, we developed new techniques for growing AlGaAs/GaAs with mobilities equalling the highest values published by any laboratory. We believe that the field of hot electron mixers and detectors will grow substantially in importance in the next few years, partly as a result of

Periodic structure with a periodicity of 2-3.5 μm on crystalline TiO2 induced by unpolarized KrF excimer lasers

NASA Astrophysics Data System (ADS)

He, Rong; Ma, Hongliang; Zheng, Jiahui; Han, Yongmei; Lu, Yuming; Cai, Chuanbing

2016-08-01

Laser-induced periodic surface structures (LIPSS) were processed on the TiO2 bulk surface under the irradiation of 248 nm unpolarized KrF excimer laser pulses in air. Spatial LIPSS periods ranging from 2 to 3.5 μm are ascribed to the capillary wave. These microstructures were analyzed at different laser pulse numbers with the laser energy from 192 to 164 mJ. The scanning electron microscopy results indicated eventually stripes that have been disrupted as the increase in the laser pulse numbers, which is reasonably explained by the energy accumulating effect. In addition, investigations were concentrated on the surface modifications at pre-focal plane, focal plane and post-focal plane in the same defocusing amount. Compared with condition at pre-focal plane, in addition to the plasma produced at target, the air was also breakdown for the situation of post-focal plane. So it was reasonable that stripes appeared at pre-focal plane but not at post-focal plane.

2. VIEW SOUTH, INCLINE PLANE CAR, INCLINE PLANE TRACK, UPPER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW SOUTH, INCLINE PLANE CAR, INCLINE PLANE TRACK, UPPER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

Implementation of focal zooming on the Nike KrF laser

NASA Astrophysics Data System (ADS)

Kehne, D. M.; Karasik, M.; Aglitsky, Y.; Smyth, Z.; Terrell, S.; Weaver, J. L.; Chan, Y.; Lehmberg, R. H.; Obenschain, S. P.

2013-01-01

In direct drive inertial confinement laser fusion, a pellet containing D-T fuel is imploded by ablation arising from absorption of laser energy at its outer surface. For optimal coupling, the focal spot of the laser would continuously decrease to match the reduction in the pellet's diameter, thereby minimizing wasted energy. A krypton-fluoride laser (λ = 248 nm) that incorporates beam smoothing by induced spatial incoherence has the ability to produce a high quality focal profile whose diameter varies with time, a property known as focal zooming. A two-stage focal zoom has been demonstrated on the Nike laser at the Naval Research Laboratory. In the experiment, a 4.4 ns laser pulse was created in which the on-target focal spot diameter was 1.3 mm (full width at half maximum) for the first 2.4 ns and 0.28 mm for the final 2 ns. These two diameters appear in time-integrated focal plane equivalent images taken at several locations in the amplification chain. Eight of the zoomed output beams were overlapped on a 60 μm thick planar polystyrene target. Time resolved images of self-emission from the rear of the target show the separate shocks launched by the two corresponding laser focal diameters.

Implementation of focal zooming on the Nike KrF laser.

PubMed

Kehne, D M; Karasik, M; Aglitsky, Y; Smyth, Z; Terrell, S; Weaver, J L; Chan, Y; Lehmberg, R H; Obenschain, S P

2013-01-01

In direct drive inertial confinement laser fusion, a pellet containing D-T fuel is imploded by ablation arising from absorption of laser energy at its outer surface. For optimal coupling, the focal spot of the laser would continuously decrease to match the reduction in the pellet's diameter, thereby minimizing wasted energy. A krypton-fluoride laser (λ = 248 nm) that incorporates beam smoothing by induced spatial incoherence has the ability to produce a high quality focal profile whose diameter varies with time, a property known as focal zooming. A two-stage focal zoom has been demonstrated on the Nike laser at the Naval Research Laboratory. In the experiment, a 4.4 ns laser pulse was created in which the on-target focal spot diameter was 1.3 mm (full width at half maximum) for the first 2.4 ns and 0.28 mm for the final 2 ns. These two diameters appear in time-integrated focal plane equivalent images taken at several locations in the amplification chain. Eight of the zoomed output beams were overlapped on a 60 μm thick planar polystyrene target. Time resolved images of self-emission from the rear of the target show the separate shocks launched by the two corresponding laser focal diameters.

Rg-Lg coupling as a Lg-wave excitation mechanism

NASA Astrophysics Data System (ADS)

Ge, Z.; Xie, X.

2003-12-01

Regional phase Lg is predominantly comprised of shear wave energy trapped in the crust. Explosion sources are expected to be less efficient for excitation of Lg phases than earthquakes to the extent that the source can be approximated as isotropic. Shallow explosions generate relatively large surface wave Rg compared to deeper earthquakes, and Rg is readily disrupted by crustal heterogeneity. Rg energy may thus scatter into trapped crustal S-waves near the source region and contribute to low-frequency Lg wave. In this study, a finite-difference modeling plus the slowness analysis are used for investigating the above mentioned Lg-wave excitation mechanism. The method allows us to investigate near source energy partitioning in multiple domains including frequency, slowness and time. The main advantage of this method is that it can be applied at close range, before Lg is actually formed, which allows us to use very fine near source velocity model to simulate the energy partitioning process. We use a layered velocity structure as the background model and add small near source random velocity patches to the model to generate the Rg to Lg coupling. Two types of simulations are conducted, (1) a fixed shallow explosion source vs. randomness at different depths and (2) a fixed shallow randomness vs. explosion sources at different depths. The results show apparent couplings between the Rg and Lg waves at lower frequencies (0.3-1.5 Hz). A shallow source combined with shallow randomness generates the maximum Lg-wave, which is consistent with the Rg energy distribution of a shallow explosion source. The Rg energy and excited Lg energy show a near linear relationship. The numerical simulation and slowness analysis suggest that the Rg to Lg coupling is an effective excitation mechanism for low frequency Lg-waves from a shallow explosion source.

Recent Developments and Applications of Quantum Well Infrared Photodetector Focal Plane Arrays

NASA Technical Reports Server (NTRS)

Gunapala, S. D.; Bandara, S. V.

2000-01-01

There are many applications that require long wavelength, large, uniform, reproducible, low cost, stable, and radiation-hard infrared (IR) focal plane arrays (FPAs). For example, the absorption lines of many gas molecules, such as ozone, water, carbon monoxide, carbon dioxide, and nitrous oxide occur in the wavelength region from 3 to 18 micron. Thus, IR imaging systems that operate in the long wavelength IR (LWIR) region (6 - 18 micron) are required in many space borne applications such as monitoring the global atmospheric temperature profiles, relative humidity profiles, cloud characteristics, and the distribution of minor constituents in the atmosphere which are being planned for future NASA Earth and planetary remote sensing systems. Due to higher radiation hardness, lower 1/f noise, and larger array size the GaAs based Quantum Well Infrared Photodetector (QWIP) FPAs are very attractive for such space borne applications compared to intrinsic narrow band gap detector arrays. In this presentation we will discuss the optimization of the detector design, material growth and processing that has culminated in realization of large format long-wavelength QWIP FPAs, portable and miniature LWIR cameras, holding forth great promise for myriad applications in 6-18 micron wavelength range in science, medicine, defense and industry. In addition, we will present some system demonstrations using broadband, two-color, and high quantum efficiency long-wavelength QWIP FPAs.

Dexamethasone effects on (/sup 125/I)albumin distribution in experimental RG-2 gliomas and adjacent brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nakagawa, H.; Groothuis, D.R.; Owens, E.S.

1987-12-01

A total of 72 RG-2 transplanted gliomas were studied in 58 rats at three time points (1, 30, 240 min) after intravenous injection of (/sup 125/I)radioiodinated serum albumin ((/sup 125/I)RISA). The animals were divided into two groups: a control group that received no treatment and a second group that was treated with five doses of 1.5 mg/kg of dexamethasone over 2.5 days. Local tissue concentrations of (/sup 125/I)RISA were measured with quantitative autoradiography based on morphological features of the tumors and used to calculate the tissue distribution space. Two models were used to analyze the data. A two compartment modelmore » yielded estimates of local blood-to-tissue influx constants (K1), lower limit extracellular volumes (Ve), and plasma vascular volumes (Vp) in different tumor regions. Treatment with dexamethasone consistently reduced the RISA distribution space in the RG-2 tumors; the reduction in Ve was statistically significant in almost all tumor regions: whole tumor Ve (mean +/- SE) was reduced from 0.14 +/- 0.02 ml g-1 in control animals to 0.08 +/- 0.01 ml g-1 in dexamethasone treated animals. K1 and Vp were also decreased in all tumor regions after treatment with dexamethasone (whole tumor K1 decreased from 2.36 +/- 0.89 to 0.83 +/- 0.29 microliter g-1 min-1 and Vp decreased slightly from 0.016 +/- 0.013 to 0.010 +/- 0.005 ml g-1 after dexamethasone treatment), but these changes were not statistically significant. A comparison of the tumor influx constants in control animals and the aqueous diffusion constants of two different size molecules (RISA and aminoisobutyric acid) suggests that the ''pores'' across RG-2 capillaries are large and may not restrict the free diffusion of RISA (estimated minimum pore diameter greater than 36 nm) and that the total pore area is approximately 6.2 X 10(-5) cm2 g-1 in RG-2 tumor tissue.« less

Efficacy of a Recombinant Turkey Herpesvirus H5 Vaccine Against Challenge With H5N1 Clades 1.1.2 and 2.3.2.1 Highly Pathogenic Avian Influenza Viruses in Domestic Ducks (Anas platyrhynchos domesticus).

PubMed

Pantin-Jackwood, Mary J; Kapczynski, Darrell R; DeJesus, Eric; Costa-Hurtado, Mar; Dauphin, Gwenaelle; Tripodi, Astrid; Dunn, John R; Swayne, David E

2016-03-01

Domestic ducks are the second most abundant poultry species in many Asian countries and have played a critical role in the epizootiology of H5N1 highly pathogenic avian influenza (HPAI).In this study, the protective efficacy of a live recombinant vector vaccine based on a turkey herpesvirus (HVT) expressing the H5 gene from a clade 2.2 H5N1 HPAI strain (A/Swan/Hungary/4999/ 2006) (rHVT-H5/2.2), given at 3 days of age, was examined in Pekin ducks (Anas platyrhynchos domesticus). The vaccine was given alone or in combination with an inactivated H5N1 clade 2.3.2.1 reverse genetic (rgGD/2.3.2.1) vaccine given at 16 days of age, either as a single vaccination or in a prime-boost regime. At 30 days of age, ducks were challenged with one of two H5N1 HPAI viruses: A/duck/Vietnam/NCVD-2721/2013 (clade 1.1.2) or A/duck/Vietnam/NCVD-1584/2012 (clade 2.3.2.1.C). These viruses produced 100% mortality in less than 5 days in nonvaccinated control ducks. Ducks vaccinated with the rgGD/2.3.2.1 vaccine, with or without the rHVT-H5/2.2 vaccine, were 90%-100% protected against mortality after challenge with either of the two H5N1 HPAI viruses. The rHVT-H5/2.2 vaccine alone, however, conferred only 30% protection against mortality after challenge with either H5N1 HPAI virus; the surviving ducks from these groups shed higher amount of virus and for longer than the single-vaccinated rgGD/2.3.2.1 group. Despite low protection, ducks vaccinated with the rHVT-H5/2.2 vaccine and challenged with the clade 1.1.2 Vietnam virus had a longer mean death time than nonvaccinated controls (P = 0.02). A booster effect was found on reduction of virus shedding when using both vaccines, with lower oropharyngeal viral titers at 4 days after challenge with either HPAI virus (P < 0.05). Neither rHVT-H5/2.2 nor standard HVT vaccine could be detected in samples collected from multiple tissues at different time points, indicting minimal levels of viral replication. In conclusion, although a minor effect on

RG-inspired machine learning for lattice field theory

NASA Astrophysics Data System (ADS)

Foreman, Sam; Giedt, Joel; Meurice, Yannick; Unmuth-Yockey, Judah

2018-03-01

Machine learning has been a fast growing field of research in several areas dealing with large datasets. We report recent attempts to use renormalization group (RG) ideas in the context of machine learning. We examine coarse graining procedures for perceptron models designed to identify the digits of the MNIST data. We discuss the correspondence between principal components analysis (PCA) and RG flows across the transition for worm configurations of the 2D Ising model. Preliminary results regarding the logarithmic divergence of the leading PCA eigenvalue were presented at the conference. More generally, we discuss the relationship between PCA and observables in Monte Carlo simulations and the possibility of reducing the number of learning parameters in supervised learning based on RG inspired hierarchical ansatzes.

Comparison of the removal of ethanethiol in twin-biotrickling filters inoculated with strain RG-1 and B350 mixed microorganisms.

PubMed

An, Taicheng; Wan, Shungang; Li, Guiying; Sun, Lei; Guo, Bin

2010-11-15

This study aims to compare the biological degradation performance of ethanethiol using strain RG-1 and B350 commercial mixed microorganisms, which were inoculated and immobilized on ceramic particles in twin-biotrickling filter columns. The parameters affecting the removal efficiency, such as empty bed residence time (EBRT) and inlet concentration, were investigated in detail. When EBRT ranged from 332 to 66 s at a fixed inlet concentration of 1.05 mg L(-1), the total removal efficiencies for RG-1 and B350 both decreased from 100% to 70.90% and 47.20%, respectively. The maximum elimination capacities for RG-1 and B350 were 38.36 (removal efficiency=89.20%) and 25.82 g m(-3) h(-1) (removal efficiency=57.10%), respectively, at an EBRT of 83 s. The variation of the inlet concentration at a fixed EBRT of 110 s did not change the removal efficiencies which remained at 100% for RG-1 and B350 at concentrations of less than 1.05 and 0.64 mg L(-1), respectively. The maximum elimination capacities were 39.93 (removal efficiency=60.30%) and 30.34 g m(-3) h(-1) (removal efficiency=46.20%) for RG-1 and B350, respectively, at an inlet concentration of 2.03 mg L(-1). Sulfate was the main metabolic product of sulfur in ethanethiol. Based the results, strain RG-1 would be a better choice than strain B350 for the biodegradation of ethanethiol. Copyright © 2010 Elsevier B.V. All rights reserved.

Rg to Lg Scattering Observations and Modeling

NASA Astrophysics Data System (ADS)

Baker, G. E.; Stevens, J. L.; Xu, H.

2005-12-01

Lg is important to explosion yield estimation and earthquake/explosion discrimination, but the source of explosion generated Lg is still an area of active investigation. We investigate the contribution of Rg scattering to Lg. Common spectral nulls in vertical component Rg and Lg have been interpreted as evidence that scattered Rg is the dominant source of Lg in some areas. The nulls are assumed to result from non-spherical components of the explosion source, modeled as a CLVD located above the explosion. We compare Rg with 3-component Sg and Lg spectra in different source areas. Wavenumber synthetics and nonlinear source calculations constrain the predicted source spectra of Rg and directly generated Lg. Modal scattering calculations place bounds on the contribution of Rg to Lg relative to pS, S*, and directly generated S-waves. Rg recorded east and west of the Quartz 3 Deep Seismic Sounding explosion have persistent spectral nulls, but at different frequencies. The azimuthal dependence of the source spectra suggests that it may not be simply related to a CLVD source. The spectral nulls of Sg, Lg, and Lg coda do not correspond to the Rg spectral nulls, so for this overburied source, the spectral observations do not indicate that Rg scattering is a dominant contributor to Lg. Preliminary comparisons of Rg with Lg spectra for events from the Semipalatinsk Test Site yield a similar result. We compare Rg at 20-100 km with Lg at 650 km for Balapan and Degelen explosions with known yield and source depth. The events range from 130 to 50 percent of theoretical containment depth, so relative contributions from a CLVD are expected to vary significantly. For studied previously NTS and Kazakh depth of burial data, the use of 3-components provides further insight into scattering between components. In a complementary analysis, to assess whether S-wave generation is affected by source depth or scaled depth, we have examined regional phase amplitudes of 13 Degelen explosions

Design of diffractive microlens array integration with focal plane arrays

NASA Astrophysics Data System (ADS)

Chen, Sihai; Yi, Xinjian; Li, Yi; He, Miao; Chen, Sixiang; Kong, Lingbin

2000-10-01

The IR spectrum from 3 to 5micrometers has numerous applications in both military and civil industries. High performance at high operating temperature is often important in these applications. Conventional Focal Plane Arrays (FPAs) without integration with concentrator such as microlens have poor sensitivity and low signal-to-noise ratio because of their lower fill factor. The binary optics microlens arrays reported in this paper are designed for integration with FPAs. Thus, the FPAs' fill factor, sensitivity, and signal- to-noise ratio can be improved while retaining a given image resolution and optical collection area. In the paper, we discussed the 256(Horizontal)x290(Vertical) microlens arrays designed for a center wavelength of 4micrometers , with 50micrometers (Horizontalx33micrometers (Vertical) quadrate pixel dimension and a speed (F number) of F/1.96. PtSi FPAs were fabricated on the front side of a 400-micrometers -thick Si substrate. The designed diffractive microlens arrays will be etched on the back side of the same wafer in a register fashion and it will be reported in other paper. Considering the diffraction efficiency, 8-phase-level approximation is enough. For the diffraction efficiency of 8-phase-level diffractive microlens reaches 95%. The process only need three mask-level, so we designed and fabricated three masks with the same dimension 4'x4'. Also, a set of fine verniers was designed and fabricated on each mask to allow accurate alignment during the fabrication process. Through a computer simulation, the microlens arrays are nearly diffraction limited, with the diffraction efficiency of 93%, a bit lower than the theoretical value of 95%. Introduction of microlens arrays has the ability to increase the FPAs' fill factor to 100%, while it is only about 21.6% without microlens. To our knowledge, this is the first trial of integration large area microlens arrays with FPAs at home.

High temperature operation In1-xAlxSb infrared focal plane

NASA Astrophysics Data System (ADS)

Lyu, Yanqiu; Si, Junjie; Cao, Xiancun; Zhang, Liang; Peng, Zhenyu; Ding, Jiaxin; Yao, Guansheng; Zhang, Xiaolei; Reobrazhenskiy, Valeriy

2016-05-01

A high temperature operation mid-wavelength 128×128 infrared focal plane arrays (FPA) based on low Al component In1-xAlxSb was presented in this work. InAlSb materials were grown on InSb (100) substrates using MBE technology, which was confirmed by XRD and AFM analyses. We have designed and grown two structures with and without barrier. The pixel of the detector had a conventional PIN structure with a size of 50μmx50μm. The device fabrication process consisted of mesa etching, passivation, metallization and flip-chip hybridization with readout integrated circuit (ROIC), epoxy backfill, lap and polish. Diode resistance, imaging, NETD and operability results are presented for a progression of structures that reduce the diode leakage current as the temperature is raised above 80K. These include addition of a thin region of InAlSb to reduce p-contact leakage current, and construction of the whole device from InAlSb to reduce thermal generation in the active region of the detector. An increase in temperature to 110K, whilst maintaining full 80K performance, is achieved. The I-V curves were measured at different temperature. Quantum efficiency, pixel operability, non-uniformity, and the mean NETD values of the FPAs were measured at 110K. This gives the prospect of significant benefits for the cooling systems, including, for example, use of argon in Joule-Thomson coolers or an increase in the life and/or decrease in the cost, power consumption and cool-down time of Stirling engines by several tens of percent.

Organic photodetectors and their applications for hemispherical imaging focal plane arrays

NASA Astrophysics Data System (ADS)

Xu, Xin

Softness of organic semiconducting materials holds promise for fabricating optoelectronic devices and circuits on nonplanar surfaces. The low growth temperature of organic small molecules also allows for the deposition onto a plastic substrate, which has the potential for significantly lowering the fabrication cost. However, the softness of organic small molecules can become problematic. Most of the well-established patterning techniques in the semiconductor industry are not suitable for patterning organic-based devices. High temperatures, high pressures, exposure to wet chemicals or high-energy particles that may exist in the conventional patterning approaches can damage the organic active layers. Although methods for large area patterning of organic electronics onto planar substrates have been demonstrated, in this thesis we extend the patterning capability to curved surfaces by using a novel three dimensional (3D) cold welding method. We use 3D cold welding to fabricate a hemispherical focal plane array (FPA) for compact imaging systems that mimic the architecture and function of the human eye. A 10 kilopixel organic photodetector FPA is thus demonstrated on a 1 cm radius hemisphere. By patterning brittle yet transparent indium tin oxide anodes instead of semitransparent metal anodes on the hemispheres, the detectivity of the FPA is improved. We introduce a sensitive hybrid photodetector employing a carbon nanotube/small molecular organic junction with a broad spectral response extending into the near infrared. Since the photodetector array shows an increased noise level with the array size, integrated arrays of organic photodetectors and thin film transistors as switches are demonstrated.

Software solution for autonomous observations with H2RG detectors and SIDECAR ASICs for the RATIR camera

NASA Astrophysics Data System (ADS)

Klein, Christopher R.; Kubánek, Petr; Butler, Nathaniel R.; Fox, Ori D.; Kutyrev, Alexander S.; Rapchun, David A.; Bloom, Joshua S.; Farah, Alejandro; Gehrels, Neil; Georgiev, Leonid; González, J. Jesús; Lee, William H.; Lotkin, Gennadiy N.; Moseley, Samuel H.; Prochaska, J. Xavier; Ramirez-Ruiz, Enrico; Richer, Michael G.; Robinson, Frederick D.; Román-Zúñiga, Carlos; Samuel, Mathew V.; Sparr, Leroy M.; Tucker, Corey; Watson, Alan M.

2012-07-01

The Reionization And Transients InfraRed (RATIR) camera has been built for rapid Gamma-Ray Burst (GRB) followup and will provide quasi-simultaneous imaging in ugriZY JH. The optical component uses two 2048 × 2048 pixel Finger Lakes Imaging ProLine detectors, one optimized for the SDSS u, g, and r bands and one optimized for the SDSS i band. The infrared portion incorporates two 2048 × 2048 pixel Teledyne HgCdTe HAWAII-2RG detectors, one with a 1.7-micron cutoff and one with a 2.5-micron cutoff. The infrared detectors are controlled by Teledyne's SIDECAR (System for Image Digitization Enhancement Control And Retrieval) ASICs (Application Specific Integrated Circuits). While other ground-based systems have used the SIDECAR before, this system also utilizes Teledyne's JADE2 (JWST ASIC Drive Electronics) interface card and IDE (Integrated Development Environment). Here we present a summary of the software developed to interface the RATIR detectors with Remote Telescope System, 2nd Version (RTS2) software. RTS2 is an integrated open source package for remote observatory control under the Linux operating system and will autonomously coordinate observatory dome, telescope pointing, detector, filter wheel, focus stage, and dewar vacuum compressor operations. Where necessary we have developed custom interfaces between RTS2 and RATIR hardware, most notably for cryogenic focus stage motor drivers and temperature controllers. All detector and hardware interface software developed for RATIR is freely available and open source as part of the RTS2 distribution.

Multiphoton versus confocal high resolution z-sectioning of enhanced green fluorescent microtubules: increased multiphoton photobleaching within the focal plane can be compensated using a Pockels cell and dual widefield detectors.

PubMed

Drummond, D R; Carter, N; Cross, R A

2002-05-01

Multiphoton excitation was originally projected to improve live cell fluorescence imaging by minimizing photobleaching effects outside the focal plane, yet reports suggest that photobleaching within the focal plane is actually worse than with one photon excitation. We confirm that when imaging enhanced green fluorescent protein, photobleaching is indeed more acute within the multiphoton excitation volume, so that whilst fluorescence increases as predicted with the square of the excitation power, photobleaching rates increase with a higher order relationship. Crucially however, multiphoton excitation also affords unique opportunities for substantial improvements to fluorescence detection. By using a Pockels cell to minimize exposure of the specimen together with multiple nondescanned detectors we show quantitatively that for any particular bleach rate multiphoton excitation produces significantly more signal than one photon excitation confocal microscopy in high resolution Z-axis sectioning of thin samples. Both modifications are readily implemented on a commercial multiphoton microscope system.

SPHEREx: Instrument and Science Implementation

NASA Astrophysics Data System (ADS)

Korngut, Phillip; SPHEREx Science Team

2018-01-01

SPHEREx, a mission in NASA's Medium Explorer (MIDEX) program that was selected for Phase A in August 2017, is an all-sky survey satellite designed to address all three science goals in NASA's astrophysics division. SPHEREx has a simple, high heritage design with large optical throughput to maximize spectral mapping speed, ideal for an all-sky spectral survey. The aluminum telescope is based on a wide-field off-axis reflective triplet design imaged by two mosaics of H2RG focal plane arrays. SPHEREx produces spectra without the use of any dispersive elements. Instead, it uses linear variable filters (LVFs) placed above the detectors to probe the wavelength range between 0.75 and 4.2 um at R=41.4 and 4.2 to 5 um at R=135. Spectra are constructed by stepping the telescope boresight across the sky, modulating the location of an object within the FOV and varying the observation wavelength in each image. The telescope is cooled by a series of three V-groove radiators to < 80K, with the two long-wavelength focal planes to < 55K. The design has ample technical margins on detector, optical, thermal, and pointing performance, and carries additional large margin on point source sensitivity.

Analysis of low-offset CTIA amplifier for small-size-pixel infrared focal plane array

NASA Astrophysics Data System (ADS)

Zhang, Xue; Huang, Zhangcheng; Shao, Xiumei

2014-11-01

The design of input stage amplifier becomes more and more difficult as the expansion of format arrays and reduction of pixel size. A design method of low-offset amplifier based on 0.18-μm process used in small-size pixel is analyzed in order to decrease the dark signal of extended wavelength InGaAs infrared focal plane arrays (IRFPA). Based on an example of a cascode operational amplifier (op-amp), the relationship between input offset voltage and size of each transistor is discussed through theoretical analysis and Monte Carlo simulation. The results indicate that input transistors and load transistors have great influence on the input offset voltage while common-gate transistors are negligible. Furthermore, the offset voltage begins to increase slightly when the width and length of transistors decrease along with the diminution of pixel size, and raises rapidly when the size is smaller than a proximate threshold value. The offset voltage of preamplifiers with differential architecture and single-shared architecture in small pitch pixel are studied. After optimization under same conditions, simulation results show that single-shared architecture has smaller offset voltage than differential architecture.

Scene-based nonuniformity correction technique that exploits knowledge of the focal-plane array readout architecture.

PubMed

Narayanan, Balaji; Hardie, Russell C; Muse, Robert A

2005-06-10

Spatial fixed-pattern noise is a common and major problem in modern infrared imagers owing to the nonuniform response of the photodiodes in the focal plane array of the imaging system. In addition, the nonuniform response of the readout and digitization electronics, which are involved in multiplexing the signals from the photodiodes, causes further nonuniformity. We describe a novel scene based on a nonuniformity correction algorithm that treats the aggregate nonuniformity in separate stages. First, the nonuniformity from the readout amplifiers is corrected by use of knowledge of the readout architecture of the imaging system. Second, the nonuniformity resulting from the individual detectors is corrected with a nonlinear filter-based method. We demonstrate the performance of the proposed algorithm by applying it to simulated imagery and real infrared data. Quantitative results in terms of the mean absolute error and the signal-to-noise ratio are also presented to demonstrate the efficacy of the proposed algorithm. One advantage of the proposed algorithm is that it requires only a few frames to obtain high-quality corrections.

Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells.

PubMed

Zhou, Yuanyuan; Zheng, Xia; Lu, Jiaojiao; Chen, Wei; Li, Xu; Zhao, Le

2018-01-01

The Warburg effect is one of the main energy metabolism features supporting cancer cell growth. 20(S)-Rg3 exerts anti-tumor effect on ovarian cancer partly by inhibiting the Warburg effect. microRNAs are important regulators of the Warburg effect. However, the microRNA regulatory network mediating the anti-Warburg effect of 20(S)-Rg3 was largely unknown. microRNA deep sequencing was performed to identify the 20(S)-Rg3-influenced microRNAs in SKOV3 ovarian cancer cells. miR-532-3p was overexpressed by mimic532-3p transfection in SKOV3 and A2780 cells or inhibited by inhibitor532-3p transfection in 20(S)-Rg3-treated cells to examine the changes in HK2 and PKM2 expression, glucose consumption, lactate production and cell growth. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-532-3p to HK2. The methylation status in the promoter region of pre-miR-532-3p gene was examined by methylation-specific PCR. Expression changes of key molecules controlling DNA methylation including DNMT1, DNMT3A, DNMT3B, and TET1-3 were examined in 20(S)-Rg3-treated cells. DNMT3A was overexpressed in 20(S)-Rg3-treated cells to examine its influence on miR-532-3p level, HK2 and PKM2 expression, glucose consumption and lactate production. Deep sequencing results showed that 11 microRNAs were increased and 9 microRNAs were decreased by 20(S)-Rg3 in SKOV3 cells, which were verified by qPCR. More than 2-fold increase of miR-532-3p was found in 20(S)-Rg3-treated SKOV3 cells. Forced expression of miR-532-3p reduced HK2 and PKM2 expression, glucose consumption and lactate production in SKOV3 and A2780 ovarian cancer cells. Inhibition of miR-532-3p antagonized the suppressive effect of 20(S)-Rg3 on HK2 and PKM2 expression, glucose consumption and lactate production in ovarian cancer cells. Dual-luciferase reporter assay showed that miR-532-3p directly suppressed HK2 rather than PKM2. miR-532-3p level was controlled by the methylation in the promoter region of its host

Solid-state Image Sensor with Focal-plane Digital Photon-counting Pixel Array

NASA Technical Reports Server (NTRS)

Fossum, Eric R.; Pain, Bedabrata

1997-01-01

A solid-state focal-plane imaging system comprises an NxN array of high gain. low-noise unit cells. each unit cell being connected to a different one of photovoltaic detector diodes, one for each unit cell, interspersed in the array for ultra low level image detection and a plurality of digital counters coupled to the outputs of the unit cell by a multiplexer(either a separate counter for each unit cell or a row of N of counters time shared with N rows of digital counters). Each unit cell includes two self-biasing cascode amplifiers in cascade for a high charge-to-voltage conversion gain (greater than 1mV/e(-)) and an electronic switch to reset input capacitance to a reference potential in order to be able to discriminate detection of an incident photon by the photoelectron (e(-))generated in the detector diode at the input of the first cascode amplifier in order to count incident photons individually in a digital counter connected to the output of the second cascade amplifier. Reseting the input capacitance and initiating self-biasing of the amplifiers occurs every clock cycle of an integratng period to enable ultralow light level image detection by the may of photovoltaic detector diodes under such ultralow light level conditions that the photon flux will statistically provide only a single photon at a time incident on anyone detector diode during any clock cycle.

Stress tensor and focal mechanisms in the Dead Sea basin

NASA Astrophysics Data System (ADS)

Hofstetter, A.; Dorbath, C.; Dorbath, L.; Braeuer, B.; Weber, M. H.

2015-12-01

We use the recorded seismicity, confined to the Dead Sea basin and its boundaries, by the Dead Sea Integrated Research (DESIRE) portable seismic network and the Israel and Jordan permanent seismic networks for studying the mechanisms of earthquakes that occurred in the Dead Sea basin. The observed seismicity in the Dead Sea basin was divided into 9 regions according to the spatial distribution of the earthquakes and the known tectonic features. The large number of recording stations and the good station distribution allowed the reliable determinations of 494 earthquake focal mechanisms. For each region, based on the inversion of the observed polarities of the earthquakes, we determine the focal mechanisms and the associated stress tensor. For 159 earthquakes out of the 494 mechanisms we could determine compatible fault planes. On the eastern side, the focal mechanisms are mainly strike-slip mechanism with nodal planes in the N-S and E-W directions. The azimuths of the stress axes are well constrained presenting minimal variability in the inversion of the data, which is in good agreement with the Arava fault on the eastern side of the Dead Sea basin and what we had expected from the regional geodynamics. However, larger variabilities of the azimuthal and dip angles are observed on the western side of the basin. Due to the wider range of azimuths of the fault planes, we observe the switching of sigma1 and sigma2 or the switching of sigma2 and sigma3as major horizontal stress directions. This observed switching of stress axes allows having dip-slip and normal mechanisms in a region that is dominated by strike-slip motion.

Challenges, constraints, and results of lens design for 17 micron-bolometer focal plane arrays in 8-12 micron waveband

NASA Astrophysics Data System (ADS)

Schuster, Norbert; Franks, John

2011-06-01

In the 8-12 micron waveband Focal Plane Arrays (FPA) are available with a 17 micron pixel pitch in different arrays sizes (e.g. 512 x 480 pixels and 320 x 240 pixels) and with excellent electrical properties. Many applications become possible using this new type of IR-detector which will become the future standard in uncooled technology. Lenses with an f-number faster than f/1.5 minimize the diffraction impact on the spatial resolution and guarantee a high thermal resolution for uncooled cameras. Both effects will be quantified. The distinction between Traditional f-number (TF) and Radiometric f-number (RF) is discussed. Lenses with different focal lengths are required for applications in a variety of markets. They are classified by their Horizontal field of view (HFOV). Respecting the requirements for high volume markets, several two lens solutions will be discussed. A commonly accepted parameter of spatial resolution is the Modulation Transfer Function (MTF)-value at the Nyquist frequency of the detector (here 30cy/mm). This parameter of resolution will be presented versus field of view. Wide Angle and Super Wide Angle lenses are susceptible to low relative illumination in the corner of the detector. Measures to reduce this drop to an acceptable value are presented.

Performance of the e2v 1.2 GPix cryogenic camera for the J-PAS 2.5m survey telescope

NASA Astrophysics Data System (ADS)

Robbins, M. S.; Bastable, M.; Bates, A.; Dryer, M.; Eames, S.; Fenemore-Jones, G.; Haddow, G.; Jorden, P. R.; Lane, B.; Marin-Franch, A.; Mortimer, J.; Palmer, I.; Puttay, N.; Renshaw, R.; Smith, M.; Taylor, K.; Tearle, J.; Weston, P.; Wheeler, P.; Worley, J.

2016-08-01

The J-PAS project will perform a five-year survey of the northern sky from a new 2.5m telescope in Teruel, Spain. In this paper the build and factory testing of the commercially supplied cryogenic camera is described. The 1.2 Giga-pixel focal plane is contained within a novel liquid-nitrogen cooled vacuum cryostat, which maintains the flatness for the cooled, 0.45m diameter focal plane to better than 27 μm peak to valley. The cooling system controls the focal plane to a temperature of -100°C with a variation across the focal plane of better than 2.5oC and a stability of better than +/- 0.5 °C over the long periods of operation required. The proximity drive electronics achieves total system level noise performance better than 5 e- from the 224-channel CCD system.

Inverse-designed stretchable metalens with tunable focal distance

NASA Astrophysics Data System (ADS)

Callewaert, Francois; Velev, Vesselin; Jiang, Shizhou; Sahakian, Alan Varteres; Kumar, Prem; Aydin, Koray

2018-02-01

In this paper, we present an inverse-designed 3D-printed all-dielectric stretchable millimeter wave metalens with a tunable focal distance. A computational inverse-design method is used to design a flat metalens made of disconnected polymer building blocks with complex shapes, as opposed to conventional monolithic lenses. The proposed metalens provides better performance than a conventional Fresnel lens, using lesser amount of material and enabling larger focal distance tunability. The metalens is fabricated using a commercial 3D-printer and attached to a stretchable platform. Measurements and simulations show that the focal distance can be tuned by a factor of 4 with a stretching factor of only 75%, a nearly diffraction-limited focal spot, and with a 70% relative focusing efficiency, defined as the ratio between power focused in the focal spot and power going through the focal plane. The proposed platform can be extended for design and fabrication of multiple electromagnetic devices working from visible to microwave radiation depending on scaling of the devices.

Development of Ultra-Low Noise, High Performance III-V Quantum Well Infrared Photodetectors (QWIPs) for Focal Plane Array Staring Image Sensor Systems

DTIC Science & Technology

1994-02-06

Ultra-Low Noise , High Performance lll-V Quantum Well Infrared Photodetectors ( QWIPs ) for Focal Plane Array Staring Image Sensor Systems i Submitted to i... QWIP , the noise is increased by the square root of the gain ,(g and the detectivity D" is reduced by this same factor. As shown in Fig. 3.18, the optimum...PI .4totekotP044l .t.,me. O IM A. AGENCY use ONLY (Leave blank) 1. y.p0AT J *fY E AND OATES CO r S - 0 1 DWveop cTteOf Ultra-Low Noise , High

Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice.

PubMed

He, Lianli; Ling, Li; Wei, Tianqin; Wang, Yaping; Xiong, Zhengai

2017-04-01

This study aims to investigate the effect as well as mechanism of ginsenoside Rg1 (Rg1) on premature ovarian failure (POF) induced by d-galactose (d-gal) in mice. C57BL/6 female mice were divided into four groups randomly, which were the saline group, the d-gal group, the d-gal + Rg1 group, and the Rg1 group. Body weight was recorded. Overall ovarian function including estrous cycles, sex hormone secretion, ovarian follicle development, and ovarian morphology was analyzed by H&E staining and ELISA. Effect of Rg1 on aging was determined by analyzing the activities of oxidation-associated biomarkers, pro-inflammatory cytokine secretion, expression of senescence-associated proteins, and fertility. Compared with the d-gal group, in Rg1 + d-gal group, body weight was increased significantly, estrous cycle block was released, and fertility and the morphology of ovaries were restored. And, Rg1 treatment after d-gal administration significantly reduced senescence-associated protein expression, increased the activity of total superoxide dismutase and glutathione peroxidase from bovine erythrocyte, and induced higher follicle stimulating hormone receptor protein expression. Additionally, the expression levels of malondialdehyde, interleukin-1β, tumor necrosis factor-α, and interleukin-6 were significantly decreased. Together, Rg1 improves mouse fertility and reduces ovarian pathological damage in d-gal-induced POF model possibly through enhancing anti-inflammatory and antioxidant capacities and reducing expression of senescence signal pathway proteins. Impact statement Ginsenoside Rg1 (Rg1) is a kind of natural estrogen and it has antioxidation and antiaging effects. However, whether Rg1 has effects on premature ovarian failure (POF) is still not clear. In this study, aging model induced by d-galactose was used to mimic POF. The effect and possible mechanism of Rg1 on ovary aging was investigated. We found that Rg1 treatment up-regulated the expression of follicle

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth

PubMed Central

Ayars, Michael; O’Sullivan, Eileen; Macgregor-Das, Anne; Shindo, Koji; Kim, Haeryoung; Borges, Michael; Yu, Jun; Hruban, Ralph H.; Goggins, Michael

2017-01-01

Pancreatic ductal adenocarcinoma evolves from precursor lesions, the most common of which is pancreatic intraepithelial neoplasia (PanIN). We performed RNA-sequencing analysis of laser capture microdissected PanINs and normal pancreatic duct cells to identify differentially expressed genes between PanINs and normal pancreatic duct, and between low-grade and high-grade PanINs. One of the most highly overexpressed transcripts identified in PanIN is interleukin-2 receptor subunit gamma (IL2RG) encoding the common gamma chain, IL2Rγ. CRISPR-mediated knockout of IL2RG in orthotopically implanted pancreatic cancer cells resulted in attenuated tumor growth in mice and reduced JAK3 expression in orthotopic tumors. These results indicate that IL2Rγ/JAK3 signaling contributes to pancreatic cancer cell growth in vivo. PMID:29137350

Geiger-mode avalanche photodiode focal plane arrays for three-dimensional imaging LADAR

NASA Astrophysics Data System (ADS)

Itzler, Mark A.; Entwistle, Mark; Owens, Mark; Patel, Ketan; Jiang, Xudong; Slomkowski, Krystyna; Rangwala, Sabbir; Zalud, Peter F.; Senko, Tom; Tower, John; Ferraro, Joseph

2010-09-01

We report on the development of focal plane arrays (FPAs) employing two-dimensional arrays of InGaAsP-based Geiger-mode avalanche photodiodes (GmAPDs). These FPAs incorporate InP/InGaAs(P) Geiger-mode avalanche photodiodes (GmAPDs) to create pixels that detect single photons at shortwave infrared wavelengths with high efficiency and low dark count rates. GmAPD arrays are hybridized to CMOS read-out integrated circuits (ROICs) that enable independent laser radar (LADAR) time-of-flight measurements for each pixel, providing three-dimensional image data at frame rates approaching 200 kHz. Microlens arrays are used to maintain high fill factor of greater than 70%. We present full-array performance maps for two different types of sensors optimized for operation at 1.06 μm and 1.55 μm, respectively. For the 1.06 μm FPAs, overall photon detection efficiency of >40% is achieved at <20 kHz dark count rates with modest cooling to ~250 K using integrated thermoelectric coolers. We also describe the first evalution of these FPAs when multi-photon pulses are incident on single pixels. The effective detection efficiency for multi-photon pulses shows excellent agreement with predictions based on Poisson statistics. We also characterize the crosstalk as a function of pulse mean photon number. Relative to the intrinsic crosstalk contribution from hot carrier luminescence that occurs during avalanche current flows resulting from single incident photons, we find a modest rise in crosstalk for multi-photon incident pulses that can be accurately explained by direct optical scattering.

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.

PubMed

Ménoret, Séverine; Ouisse, Laure-Hélène; Tesson, Laurent; Delbos, Frédéric; Garnier, Delphine; Remy, Séverine; Usal, Claire; Concordet, Jean-Paul; Giovannangeli, Carine; Chenouard, Vanessa; Brusselle, Lucas; Merieau, Emmanuel; Nerrière-Daguin, Véronique; Duteille, Franck; Bellier-Waast, Frédérique; Fraichard, Alexandre; Nguyen, Tuan H; Anegon, Ignacio

2018-04-24

Immunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune responses. Nevertheless, there are models and experimental situations that would beneficiate of larger immunodeficient recipients. Rats are ideally suited to perform experiments in which larger size is needed and are still a small animal model suitable for rodent facilities. Additionally, rats reproduce certain human diseases better than mice, such as ankylosing spondylitis and Duchenne disease and these disease models would greatly benefit of immunodeficient rats to test different immunogenic treatments. We describe the generation of Il2rg-deficient rats and their crossing with previously described Rag1-deficient rats to generate double-mutant RRG animals. As compared to Rag1-deficient rats, Il2rg-deficient rats were more immunodeficient since partially lacked not only T and B cells but also NK cells. RRG animals showed a more profound immunossuppressed phenotype since they displayed undetectable levels of T, B and NK cells. Similarly, all immunoglobulin isotypes in sera were decreased in Rag1 or Il2rg-deficient rats and undetectable in RRG animals. Rag1 or Il2rg-deficient rats rejected allogeneic skin transplants and human tumors whereas RRG animals not only accepted allogeneic rat skin but also xenogeneic human tumors, skin and hepatocytes. Immune humanization of RRG animals was unsuccessful. Thus, immunodeficient RRG animals are useful recipients for long term studies in which immune responses could be an obstacle, including tissue humanization of different tissues.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Life-finding detector development at NASA GSFC using a custom H4RG test bed

NASA Astrophysics Data System (ADS)

Mosby, Gregory; Rauscher, Bernard; Kutyrev, Alexander

2018-01-01

Chemical species associated with life, called biosignatures, should be visible in exoplanet atmospheres with larger space telescopes. These signals will be faint and require very low noise (~e-) detectors to robustly measure. At NASA Goddard we are developing a single detector H4RG test bed to characterize and identify potential technology developments needed for the next generation's large space telescopes. The vacuum and cryogenic test bed will include near infrared light sources from integrating spheres using a motorized shutter. The detector control and readout will be handled by a Leach controller. Detector cables have been manufactured and test planning has begun. Planned tests include testing minimum read noise capabilities, persistence mitigation strategies using long wavelength light, and measuring intrapixel variation which might affect science goals of future missions. In addition to providing a means to identify areas of improvement in detector technology, we hope to use this test bed to probe some fundamental physics of these infrared arrays.

DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer

PubMed Central

Ou, Yao; Zhang, Quan; Tang, Yiting; Lu, Zhonghua; Lu, Xujing; Zhou, Xifa; Liu, Changmin

2018-01-01

Esophageal cancer (EC) is the eighth most common highly aggressive cancer worldwide. The purpose of this study was to investigate the effect of the DNA methyltransferase inhibitor RG108 on the radiosensitivity of EC cells. MTT and clonogenic assays were performed to assess the effect of RG108 on the proliferation and radiosensitivity of Eca-109 and TE-1 human EC cells. The cell cycle progression and alterations in apoptosis were analyzed by flow cytometry. For the in vivo analysis, the Eca-109 cells were inoculated into nude mice to establish tumors. Tissues from xenografts were obtained to detect changes to microvessels and tumor growth by immunohistochemistry (IHC). RNA-seq was used to identify differentially expressed genes. We found that RG108 increased the radiosensitivity of EC cells. Apoptosis and G2/M-phase arrest were induced by X-ray irradiation and were significantly enhanced by RG108. In addition, growth of tumor xenografts from the Eca-109 cells was significantly inhibited by irradiation in combination with RG108. The RNA-seq analysis revealed that, compared with radiation alone, X-ray irradiation in combination with RG108 altered the expression of 121 genes in multiple pathways, including the TGF-β signaling pathway and the Epstein-Barr virus infection pathway. In conclusion, RG108 induced radiosensitivity in EC cells both in vitro and in vivo. PMID:29328411

Vacuum packaging of InGaAs focal plane array with four-stage thermoelectric cooler

NASA Astrophysics Data System (ADS)

Mo, De-feng; Liu, Da-fu; Yang, Li-yi; Xu, Qin-fei; Li, Xue

2013-09-01

The InGaAs focal plane array (FPA) detectors, covering the near-infrared 1~2.4 μm wavelength range, have been developed for application in space-based spectroscopy of the Earth atmosphere. This paper shows an all-metal vacuum package design for area array InGaAs detector of 1024×64 pixels, and its architecture will be given. Four-stage thermoelectric cooler (TEC) is used to cool down the FPA chip. To acquire high heat dissipation for TEC's Joule-heat, tungsten copper (CuW80) and kovar (4J29) is used as motherboard and cavity material respectively which joined by brazing. The heat loss including conduction, convection and radiation is analyzed. Finite element model is established to analyze the temperature uniformity of the chip substrate which is made of aluminum nitride (AlN). The performance of The TEC with and without heat load in vacuum condition is tested. The results show that the heat load has little influence to current-voltage relationship of TEC. The temperature difference (ΔT) increases as the input current increases. A linear relationship exists between heat load and ΔT of the TEC. Theoretical analysis and calculation show that the heat loss of radiation and conduction is about 187 mW and 82 mW respectively. Considering the Joule-heat of readout circuit and the heat loss of radiation and conduction, the FPA for a 220 K operation at room temperature can be achieved. As the thickness of AlN chip substrate is thicker than 1 millimeter, the temperature difference can be less than 0.3 K.

VizieR Online Data Catalog: UWISH2 extended H2 emission line sources (Froebrich+, 2015)

NASA Astrophysics Data System (ADS)

Froebrich, D.; Makin, S. V.; Davis, C. J.; Gledhill, T. M.; Kim, Y.; Koo, B.-C.; Rowles, J.; Eisloffel, J.; Nicholas, J.; Lee, J. J.; Williamson, J.; Buckner, A. S. M.

2016-07-01

All data were acquired using the Wide Field Camera (WFCAM) on the United Kingdom Infrared Telescope (UKIRT), Mauna Kea, Hawaii. WFCAM houses four Rockwell Hawaii-II (HgCdTe 2048x2048-pixel) arrays spaced by 94 per cent in the focal plane. The pixel scale measures 0.4-arcsec, although microstepping is used to generate reduced mosaics with a 0.2-arcsec pixel scale and thereby fully sample the expected seeing. (3 data files).

Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells

PubMed Central

Choi, Yoon-Hee; Lee, Hyun Sook; Chung, Cha-Kwon

2017-01-01

BACKGROUND/OBJECTIVE Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP. The protective effects of AK-Ex against AAP-induced hepatotoxicity in HepG2 and HepaRG cells were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, lactate dehydrogenase (LDH) assay, flow cytometry, and Western blotting. RESULTS AK-Ex, when administered prior to AAP, increased cell growth and decreased leakage of LDH in a dose-dependent manner in HepG2 and HepaRG cells against AAP-induced hepatotoxicity. AK-Ex increased the level of Bcl-2 and decreased the levels of Bax, Bok and Bik decreased the permeability of the mitochondrial membrane in HepG2 cells intoxicated with AAP. AK-Ex decreased the cleavage of poly (ADP-ribose) polymerase (PARP) and the activation of caspase-9, -7, and -3. CONCLUSIONS These results demonstrate that AK-Ex downregulates apoptosis via intrinsic and extrinsic pathways against AAP-induced hepatotoxicity. We suggest that AK could be a useful preventive agent against AAP-induced apoptosis in hepatocytes. PMID:28386382

Kepler Commissioning Data for Measurement of the Pixel Response Function and Focal Plane Geometry

NASA Technical Reports Server (NTRS)

Bryson, Stephen T.

2017-01-01

This document describes the Kepler PRF/FPG data release. This data was taken on April 27-29, 2009, during Kepler's commissioning phase in order to measure the pixel response function (PRF) (Bryson et al., 2010a) and focal plane geometry (FPG) (Tenenbaum and Jenkins, 2010). 33,424 stellar targets were observed for 243 long cadences, each with a duration of 14.7 minutes (half the duration of a normal Kepler long cadence). During these 243 cadences the Kepler photometer was moved, pointing in a dither pattern to facilitate PRF measurement. Motion occurred during the even cadences (second, fourth, etc.), with the telescope in stable fine point at each pointing in the dither pattern during the odd cadences (first, third, etc.). The first and last cadences were at the center of the dither pattern. Motion cadences are included in this release, but they do not contain any data. For details on how this data was used to derive the Kepler PRF and FPG models, see Bryson et al. (2010a) and Tenenbaum and Jenkins (2010). Descriptions of the PRF and FPG models are found in Thompson et al. (2016), x2.3.5.17 and x2.3.5.16 respectively. The data in this release can be used to recompute the Kepler PRF and FPG. Such a reconstruction, however, would not reflect measured seasonal changes in the PRF described in Van Cleve et al. (2016b), x5.2.The dither pattern is shown in Figure 1. The crosses show the commanded pointings and the circles show the measured pointings. Measured pointings are different from the commanded pointings due to the early state of calibration of the fine guidance sensors during commissioning (Van Cleve et al., 2016a). The measured offsets from the center of the pattern are given in RADEC offsets and pixel offsets in Table 1. The order of the offsets was randomized during data collection to avoid time-dependent systematics.

Active hyperspectral imaging using a quantum cascade laser (QCL) array and digital-pixel focal plane array (DFPA) camera.

PubMed

Goyal, Anish; Myers, Travis; Wang, Christine A; Kelly, Michael; Tyrrell, Brian; Gokden, B; Sanchez, Antonio; Turner, George; Capasso, Federico

2014-06-16

We demonstrate active hyperspectral imaging using a quantum-cascade laser (QCL) array as the illumination source and a digital-pixel focal-plane-array (DFPA) camera as the receiver. The multi-wavelength QCL array used in this work comprises 15 individually addressable QCLs in which the beams from all lasers are spatially overlapped using wavelength beam combining (WBC). The DFPA camera was configured to integrate the laser light reflected from the sample and to perform on-chip subtraction of the passive thermal background. A 27-frame hyperspectral image was acquired of a liquid contaminant on a diffuse gold surface at a range of 5 meters. The measured spectral reflectance closely matches the calculated reflectance. Furthermore, the high-speed capabilities of the system were demonstrated by capturing differential reflectance images of sand and KClO₃ particles that were moving at speeds of up to 10 m/s.

77 FR 47670 - RG Steel Sparrows Point LLC, Formerly Known as Severstal Sparrows Point LLC, a Subsidiary of RG...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,919] RG Steel Sparrows Point LLC, Formerly Known as Severstal Sparrows Point LLC, a Subsidiary of RG Steel LLC, Including All On-Site Leased Workers, Sparrows Point, MD; Amended Certification Regarding Eligibility To Apply for...

Numerical simulation of the modulation transfer function (MTF) in infrared focal plane arrays: simulation methodology and MTF optimization

NASA Astrophysics Data System (ADS)

Schuster, J.

2018-02-01

Military requirements demand both single and dual-color infrared (IR) imaging systems with both high resolution and sharp contrast. To quantify the performance of these imaging systems, a key measure of performance, the modulation transfer function (MTF), describes how well an optical system reproduces an objects contrast in the image plane at different spatial frequencies. At the center of an IR imaging system is the focal plane array (FPA). IR FPAs are hybrid structures consisting of a semiconductor detector pixel array, typically fabricated from HgCdTe, InGaAs or III-V superlattice materials, hybridized with heat/pressure to a silicon read-out integrated circuit (ROIC) with indium bumps on each pixel providing the mechanical and electrical connection. Due to the growing sophistication of the pixel arrays in these FPAs, sophisticated modeling techniques are required to predict, understand, and benchmark the pixel array MTF that contributes to the total imaging system MTF. To model the pixel array MTF, computationally exhaustive 2D and 3D numerical simulation approaches are required to correctly account for complex architectures and effects such as lateral diffusion from the pixel corners. It is paramount to accurately model the lateral di_usion (pixel crosstalk) as it can become the dominant mechanism limiting the detector MTF if not properly mitigated. Once the detector MTF has been simulated, it is directly decomposed into its constituent contributions to reveal exactly what is limiting the total detector MTF, providing a path for optimization. An overview of the MTF will be given and the simulation approach will be discussed in detail, along with how different simulation parameters effect the MTF calculation. Finally, MTF optimization strategies (crosstalk mitigation) will be discussed.

Antibodies against the mono-methylated arginine-glycine repeat (MMA-RG) of the Epstein-Barr virus nuclear antigen 2 (EBNA2) identify potential cellular proteins targeted in viral transformation.

PubMed

Ayoubian, Hiresh; Fröhlich, Thomas; Pogodski, Dagmar; Flatley, Andrew; Kremmer, Elisabeth; Schepers, Aloys; Feederle, Regina; Arnold, Georg J; Grässer, Friedrich A

2017-08-01

The Epstein-Barr virus is a human herpes virus with oncogenic potential. The virus-encoded nuclear antigen 2 (EBNA2) is a key mediator of viral tumorigenesis. EBNA2 features an arginine-glycine (RG) repeat at amino acids (aa)339-354 that is essential for the transformation of lymphocytes and contains symmetrically (SDMA) and asymmetrically (ADMA) di-methylated arginine residues. The SDMA-modified EBNA2 binds the survival motor neuron protein (SMN), thus mimicking SMD3, a cellular SDMA-containing protein that interacts with SMN. Accordingly, a monoclonal antibody (mAb) specific for the SDMA-modified RG repeat of EBNA2 also binds to SMD3. With the novel mAb 19D4 we now show that EBNA2 contains mono-methylated arginine (MMA) residues within the RG repeat. Using 19D4, we immune-precipitated and analysed by mass spectrometry cellular proteins in EBV-transformed B-cells that feature MMA motifs that are similar to the one in EBNA2. Among the cellular proteins identified, we confirmed by immunoprecipitation and/or Western blot analyses Aly/REF, Coilin, DDX5, FXR1, HNRNPK, LSM4, MRE11, NRIP, nucleolin, PRPF8, RBM26, SMD1 (SNRDP1) and THRAP3 proteins that are either known to contain MMA residues or feature RG repeat sequences that probably serve as methylation substrates. The identified proteins are involved in splicing, tumorigenesis, transcriptional activation, DNA stability and RNA processing or export. Furthermore, we found that several proteins involved in energy metabolism are associated with MMA-modified proteins. Interestingly, the viral EBNA1 protein that features methylated RG repeat motifs also reacted with the antibodies. Our results indicate that the region between aa 34-52 of EBNA1 contains ADMA or SDMA residues, while the region between aa 328-377 mainly contains MMA residues.

Construction of a photometer to detect stellar occultations by outer solar system bodies for the Whipple mission concept

NASA Astrophysics Data System (ADS)

Kraft, Ralph P.; Kenter, Almus T.; Alcock, Charles; Murray, Stephen S.; Loose, Markus; Gauron, Thomas; Germain, Gregg; Peregrim, Lawrence

2014-08-01

The Whipple mission was a proposal submitted to the NASA Discovery AO in 2010 to study the solid bodies of the Kuiper Belt and Oort Cloud via a blind occultation survey. Though not accepted for flight, the proposal was awarded funding for technology development. Detecting a significant number of Trans Neptunian Objects (TNOs) via a blind occultation survey requires a low noise, wide field of view, multi object differential photometer. The light curve decrement is typically a few percent over timescales of tenths of seconds or seconds for Kuiper Belt and Oort cloud objects, respectively. To obtain a statistically interesting number of detections, this photometer needs to observe many thousands of stars over several years since the rate of occultation for a single star given the space density of the TNOs is low. The light curves from these stars must be monitored with a sensor with a temporal resolution of rv 25-50 ms and with a read noise of< 20 e- rms. Since these requirements are outside the capability of CCDs, the Whipple mission intends to use Teledyne H2RG HyViSI Silicon Hybrid CMOS detectors operating in "window" read mode. The full Whipple focal plane consists of a 3x3 array of these sensors, with each sensor comprised of 1024x 1024 36/μm pixels. Combined with the telescope optic, the Whipple focal plane provides a FOV of rv36 deg2 . In operation, each HyViSI detector, coupled to a Teledyne SIDECAR ASIC, monitors the flux from 650 stars at 40 Hz. The ASIC digitizes the data at the required cadence and an FPGA provides preliminary occultation event selection. The proposed 2010 Whipple mission utilized a spacecraft in a a "drift-away" orbit which signifi­ cantly limited the available telemetry data rate. Most of the light curve processing is required to be on-board the satellite so only candidate occultation events are telemetered to the ground. Occul­ tation light curves must be processed in real time on the satellite by an Field Programmable Gate Array

Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance-Associated Substitutions in Ferrets.

PubMed

Pascua, Philippe Noriel Q; Marathe, Bindumadhav M; Burnham, Andrew J; Vogel, Peter; Webby, Richard J; Webster, Robert G; Govorkova, Elena A

2016-01-01

Neuraminidase (NA) inhibitors (NAIs) are the only antiviral drugs recommended for influenza treatment and prophylaxis. Although NAI-resistant influenza B viruses that could pose a threat to public health have been reported in the field, their fitness is poorly understood. We evaluated in ferrets the pathogenicity and relative fitness of reverse genetics (rg)-generated influenza B/Yamanashi/166/1998-like viruses containing E119A or H274Y NA substitutions (N2 numbering). Ferrets inoculated with NAI-susceptible rg-wild-type (rg-WT) or NAI-resistant (rg-E119A or rg-H274Y) viruses developed mild infections. Growth of rg-E119A virus in the nasal cavities was delayed, but the high titers at 3 days post-inoculation (dpi) were comparable to those of the rg-WT and rg-H274Y viruses (3.6-4.1 log10TCID50/mL). No virus persisted beyond 5 dpi and replication did not extend to the trachea or lungs. Positive virus antigen-staining of the nasal turbinate epithelium was intermittent with the rg-WT and rg-H274Y viruses; whereas antigen-staining for the rg-E119A virus was more diffuse. Virus populations in ferrets coinoculated with NAI-susceptible and -resistant viruses (1:1 mixture) remained heterogeneous at 5 dpi but were predominantly rg-WT (>70%). Although the E119A substitution was associated with delayed replication in ferrets, the H274Y substitution did not measurably affect viral growth properties. These data suggest that rg-H274Y has undiminished fitness in single virus inoculations, but neither rg-E119A nor rg-H274Y gained a fitness advantage over rg-WT in direct competition experiments without antiviral drug pressure. Taken together, our data suggest the following order of relative fitness in a ferret animal model: rg-WT > rg-H274Y > rg-E119A.

Neuroprotective effects of ginsenoside Rg1 against oxygen-glucose deprivation in cultured hippocampal neurons.

PubMed

He, Qing; Sun, Jianguo; Wang, Qin; Wang, Wei; He, Bin

2014-03-01

Ginsenoside Rg1 (Rg1) is believed to be one of the main active principles in ginseng, a traditional Chinese medicine extensively used to enhance stamina and deal with fatigue as well as physical stress. It has been reported that Rg1 performs multiple biological activities, including neuroprotective activity. In this study, we investigated the efficacy of ginsenoside Rg1 on ischemia-reperfusion injury in cultured hippocampal cells and also probed its possible mechanisms. To establish a model of oxygen-glucose deprivation (OGD) and reperfusion, cultured hippocampal neurons were exposed to OGD for 2.5 hours, followed by a 24-hour reoxygenation. Cultured hippocampal neurons were randomly divided into control group, model group (vehicle), and ginsenoside Rg1 treatment groups (5μM, 20μM, 60μM). At 24 hours post-OGD, the intracellular free calcium concentration was detected using Furo-3/AM-loaded hippocampal neurons deprived of oxygen and glucose. Neuronal nitric oxide synthase (nNOS) activity was measured by chemical colorimetry. Cell apoptosis was evaluated by Hoechst staining, and the neuron viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Excitotoxic neuronal injury of OGD was demonstrated by the increase of intracellular free calcium concentrations and elevated nNOS activity in the model group compared with the control group. The intracellular free calcium concentrations and the nNOS activity in the groups receiving intermediate and high dose of ginsenoside Rg1 were significantly lower than those of the control group (p < 0.05). In addition, intermediate and high dose of ginsenoside Rg1 administration could also attenuate the cell viability loss (p < 0.05) and cell apoptosis induced by OGD. Ginsenoside Rg1 has neuroprotective effect on ischemia-reperfusion injury in cultured hippocampal cells mediated by blocking calcium over-influx into neuronal cells and decreasing the nNOS activity after OGD exposure. We infer

Boomerang RG flows in M-theory with intermediate scaling

NASA Astrophysics Data System (ADS)

Donos, Aristomenis; Gauntlett, Jerome P.; Rosen, Christopher; Sosa-Rodriguez, Omar

2017-07-01

We construct novel RG flows of D=11 supergravity that asymptotically approach AdS 4 × S 7 in the UV with deformations that break spatial translations in the dual field theory. In the IR the solutions return to exactly the same AdS 4 × S 7 vacuum, with a renormalisation of relative length scales, and hence we refer to the flows as `boomerang RG flows'. For sufficiently large deformations, on the way to the IR the solutions also approach two distinct intermediate scaling regimes, each with hyperscaling violation. The first regime is Lorentz invariant with dynamical exponent z = 1 while the second has z = 5/2. Neither ofthe two intermediatescaling regimesare associatedwith exact hyperscaling violation solutions of D = 11 supergravity. The RG flow solutions are constructed using the four dimensional N = 2 STU gauged supergravity theory with vanishing gauge fields, but non-vanishing scalar and pseudoscalar fields. In the ABJM dual field theory the flows are driven by spatially modulated deformation parameters for scalar and fermion bilinear operators.

Spatial-heterodyne sampling requirements in the off-axis pupil plane recording geometry for deep-turbulence wavefront sensing

NASA Astrophysics Data System (ADS)

Banet, Matthias T.; Spencer, Mark F.

2017-09-01

Spatial-heterodyne interferometry is a robust solution for deep-turbulence wavefront sensing. With that said, this paper analyzes the focal-plane array sampling requirements for spatial-heterodyne systems operating in the off-axis pupil plane recording geometry. To assess spatial-heterodyne performance, we use a metric referred to as the field-estimated Strehl ratio. We first develop an analytical description of performance with respect to the number of focal-plane array pixels across the Fried coherence diameter and then verify our results with wave-optics simulations. The analysis indicates that at approximately 5 focal-plane array pixels across the Fried coherence diameter, the field-estimated Strehl ratios begin to exceed 0:9 which is indicative of largely diffraction-limited results.

Quantum superalgebra slq( {2}/{1}) on the Poincaré half-plane

NASA Astrophysics Data System (ADS)

Jellal, A.

2001-02-01

We find that the symmetry algebra for the motion of a spin- {1}/{2} electron moving in the Poincaré upper half-plane ( H) under the action of a constant magnetic field (orthogonal to H) is the quantum superalgebra slq( {2}/{1}). From this, and using representation theory, we are able to determine the degree of degeneracy of the lowest Landau level when q is a root of unity.

Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance–Associated Substitutions in Ferrets

PubMed Central

Pascua, Philippe Noriel Q.; Marathe, Bindumadhav M.; Burnham, Andrew J.; Vogel, Peter; Webby, Richard J.; Webster, Robert G.; Govorkova, Elena A.

2016-01-01

Neuraminidase (NA) inhibitors (NAIs) are the only antiviral drugs recommended for influenza treatment and prophylaxis. Although NAI-resistant influenza B viruses that could pose a threat to public health have been reported in the field, their fitness is poorly understood. We evaluated in ferrets the pathogenicity and relative fitness of reverse genetics (rg)–generated influenza B/Yamanashi/166/1998-like viruses containing E119A or H274Y NA substitutions (N2 numbering). Ferrets inoculated with NAI-susceptible rg–wild-type (rg-WT) or NAI-resistant (rg-E119A or rg-H274Y) viruses developed mild infections. Growth of rg-E119A virus in the nasal cavities was delayed, but the high titers at 3 days post-inoculation (dpi) were comparable to those of the rg-WT and rg-H274Y viruses (3.6–4.1 log10TCID50/mL). No virus persisted beyond 5 dpi and replication did not extend to the trachea or lungs. Positive virus antigen-staining of the nasal turbinate epithelium was intermittent with the rg-WT and rg-H274Y viruses; whereas antigen-staining for the rg-E119A virus was more diffuse. Virus populations in ferrets coinoculated with NAI-susceptible and -resistant viruses (1:1 mixture) remained heterogeneous at 5 dpi but were predominantly rg-WT (>70%). Although the E119A substitution was associated with delayed replication in ferrets, the H274Y substitution did not measurably affect viral growth properties. These data suggest that rg-H274Y has undiminished fitness in single virus inoculations, but neither rg-E119A nor rg-H274Y gained a fitness advantage over rg-WT in direct competition experiments without antiviral drug pressure. Taken together, our data suggest the following order of relative fitness in a ferret animal model: rg-WT > rg-H274Y > rg-E119A. PMID:27466813

[The bonding characteristic of titanium and RG experiment porcelain].

PubMed

Ren, Wei-hong; Guo, Tian-wen; Tian, Jie-mo; Zhang, Yun-long

2003-07-01

To study the bonding characteristic of Titanium and RG experiment porcelain. 5 specimens with a size of 10 mm x 5 mm x 1.4 mm were cast from pure titanium. Then 1 mm of RG experiment opaque and body porcelain were fused on the surface of the titanium specimens. The interface of titanium and porcelain was analyzed with a scanning electron microscope with energy-despersive spectrometry; 6 metal specimens with the size of 25 mm x 3 mm x 0.5 mm were cast from Ni-Cr alloy and a uniform thickness of 1 mm of VMK 99 porcelain was veneered on the central area of 8 mm x 3 mm 18 metal specimens as the same size were cast from pure titanium. The uniform thickness of 1 mm of VITA TITANKERAMIK porcelain, of Noritake super porcelain Ti-22 and of RG experiment porcelain were veneered on every 6 specimens respectively in the central area of 8 mm x 3 mm. The specimens were subjected to a three-point bending test on a load-test machine with a span of 20 mm, then the failure loads were recorded and statistically analysised. The RG porcelain/titanium crown was fabricated by fusing RG opaque porcelain and body porcelain to cast titanium substrate crown. The SEM results show no porosity and crackle were found in the interface. The energy-dispersive spectrometry show that there are Si, Ti and O in the 1 micro m layer between porcelain and titanium, which suggesting titanium and experiment porcelain bonding well. The three point test showed the fracture force for the combinations of titanium/VITA TITANKERAMIK porcelain, titanium/Noritake super porcelain Ti-22 and titanium/RG experiment porcelain were (7.233 +/- 2.539) N, (5.533 +/- 1.199) N and (6.316 +/- 1.433) N respectively. There were not statistically significant differences among them (t test, P < 0.01). The fracture force for the Ni-Cr alloy/VMK99 porcelain combination (12.733 +/- 3.297) N was significantly greater than those of the cast titanium/porcelain (t test, P > 0.05). The crown was translucent with no crack. RG porcelain is

Diatomics-in-molecules description of the Rg-Hal2 rare gas-halogen van der Waals complexes with applications to He-Cl2

NASA Astrophysics Data System (ADS)

Grigorenko, B. L.; Nemukhin, A. V.; Buchachenko, A. A.; Stepanov, N. F.; Umanskii, S. Ya.

1997-03-01

The diatomics-in-molecules (DIM) technique is applied for a description of the low-lying states of the Rg-Hal2 van der Waals complexes correlating with the lowest states of constituent atoms Rg(1S)+Hal(2Pj)+Hal(2Pj). The important feature of this approach is the construction of polyatomic basis functions as products of the Hal2 diatomic eigenstates classified within the Hund "c" scheme and the atomic rare gas wave function. Necessary transformations to the other basis set representations are described, and finally all the matrix elements are expressed in terms of nonrelativistic adiabatic energies of Hal2 and Rg Hal fragments and spin-orbit splitting constant of the halogen atom. Our main concern is to test the DIM-based approximations of different levels taking the He-Cl2 system as an example. Namely, we have compared the results obtained within a hierarchy of approaches: (1) the simplest pairwise potential scheme as a far extreme of the DIM model, (2) the same as (1) but with the different components (Σ and Π) for He-Cl interaction, (3) the accurate DIM technique without spin-orbit terms, and (4) the highest level which takes into account all these contributions. The results have been compared to the other DIM like models as well. The shapes of two-dimensional potential surfaces for the ground (X) and excited (B) states of HeCl2, binding energies De with respect to He+Cl2, stretching and bending vibrational frequencies of the complex, binding energies D0, and spectral shifts for the B←X transition are discussed.

Development of the Focal Plane Detection System for the Future Gas-Filled Separator at the Cyclotron Institute

NASA Astrophysics Data System (ADS)

Bertelsen, Erin; Mayorov, Dmitriy; Folden, Charles ``Cody'', III

2015-10-01

A focal plane detection system is being developed for use with the gas-filled separator previously known as SASSYER (Small Angle Separator System at Yale for Evaporation Residues) that will be installed at the Cyclotron Institute at Texas A&M University. This system will be used to study heavy (Z >= 90) elements and features two 60×40 strip double-sided silicon detectors (DSSDs) and accompanying multiplexing read-out electronics. The DSSDs cover an area of 120×40 mm2 and are read-out by fourteen 16-channel multiplexers (Mesytec MUX-16) that perform the function of a preamplifier, shaper, and leading-edge discriminator in one unit. The multiplexers are controlled by four ``MUX drivers,'' each of which serves as a signal bus for multiple MUX-16 boards. The system allows a single 16-channel ADC to read the combined 200 strips of both DSSDs. A four peak source composed of 148Gd, 239Pu, 241Am, and 244Cm was used to characterize the performance of the system, with a preliminary energy resolution of ~ 60 keV measured for the 241Am alphas. This contribution will discuss the work performed in assembly of the test setup, optimization and performance check of the multiplexers, and the preliminary energy and position data collected with the α-source. Present address: Los Alamos National Laboratory, Los Alamos, NM 87545.

Advances in Focal Plane Wavefront Estimation for Directly Imaging Exoplanets

NASA Astrophysics Data System (ADS)

Eldorado Riggs, A. J.; Kasdin, N. Jeremy; Groff, Tyler Dean

2015-01-01

To image cold exoplanets directly in visible light, an instrument on a telescope needs to suppress starlight by about 9 orders of magnitude at small separations from the star. A coronagraph changes the point spread function to create regions of high contrast where exoplanets or disks can be seen. Aberrations on the optics degrade the contrast by several orders of magnitude, so all high-contrast imaging systems incorporate one or more deformable mirrors (DMs) to recover regions of high contrast. With a coronagraphic instrument planned for the WFIRST-AFTA space telescope, there is a pressing need for faster, more robust estimation and control schemes for the DMs. Non-common path aberrations limit conventional phase conjugation schemes to medium star-to-planet contrast ratios of about 1e-6. High-contrast imaging requires estimation and control of both phase and amplitude in the same beam path as the science camera. Field estimation is a challenge since only intensity is measured; the most common approach, including that planned for WFIRST-AFTA, is to use DMs to create diversity, via pairs of small probe shapes, thereby allowing disambiguation of the electric field. Most implementations of DM Diversity require at least five images per electric field estimate and require narrowband measurements. This paper describes our new estimation algorithms that improve the speed (by using fewer images) and bandwidth of focal plane wavefront estimation. For narrowband estimation, we are testing nonlinear, recursive algorithms such as an iterative extended Kalman filter (IEKF) to use three images each iteration and build better, more robust estimates. We are also exploring the use of broadband estimation without the need for narrowband sub-filters and measurements. Here we present simulations of these algorithms with realistic noise and small signals to show how they might perform for WFIRST-AFTA. Once validated in simulations, we will test these algorithms experimentally in

Shutterless solution for simultaneous focal plane array temperature estimation and nonuniformity correction in uncooled long-wave infrared camera.

PubMed

Cao, Yanpeng; Tisse, Christel-Loic

2013-09-01

In uncooled long-wave infrared (LWIR) microbolometer imaging systems, temperature fluctuations of the focal plane array (FPA) result in thermal drift and spatial nonuniformity. In this paper, we present a novel approach based on single-image processing to simultaneously estimate temperature variances of FPAs and compensate the resulting temperature-dependent nonuniformity. Through well-controlled thermal calibrations, empirical behavioral models are derived to characterize the relationship between the responses of microbolometer and FPA temperature variations. Then, under the assumption that strong dependency exists between spatially adjacent pixels, we estimate the optimal FPA temperature so as to minimize the global intensity variance across the entire thermal infrared image. We make use of the estimated FPA temperature to infer an appropriate nonuniformity correction (NUC) profile. The performance and robustness of the proposed temperature-adaptive NUC method are evaluated on realistic IR images obtained by a 640 × 512 pixels uncooled LWIR microbolometer imaging system operating in a significantly changed temperature environment.

Reflectance calibration of focal plane array hyperspectral imaging system for agricultural and food safety applications

NASA Astrophysics Data System (ADS)

Lawrence, Kurt C.; Park, Bosoon; Windham, William R.; Mao, Chengye; Poole, Gavin H.

2003-03-01

A method to calibrate a pushbroom hyperspectral imaging system for "near-field" applications in agricultural and food safety has been demonstrated. The method consists of a modified geometric control point correction applied to a focal plane array to remove smile and keystone distortion from the system. Once a FPA correction was applied, single wavelength and distance calibrations were used to describe all points on the FPA. Finally, a percent reflectance calibration, applied on a pixel-by-pixel basis, was used for accurate measurements for the hyperspectral imaging system. The method was demonstrated with a stationary prism-grating-prism, pushbroom hyperspectral imaging system. For the system described, wavelength and distance calibrations were used to reduce the wavelength errors to <0.5 nm and distance errors to <0.01mm (across the entrance slit width). The pixel-by-pixel percent reflectance calibration, which was performed at all wavelengths with dark current and 99% reflectance calibration-panel measurements, was verified with measurements on a certified gradient Spectralon panel with values ranging from about 14% reflectance to 99% reflectance with errors generally less than 5% at the mid-wavelength measurements. Results from the calibration method, indicate the hyperspectral imaging system has a usable range between 420 nm and 840 nm. Outside this range, errors increase significantly.

Generation of uniformly oriented in-plane magnetization with near-unity purity in 4π microscopy.

PubMed

Wang, Sicong; Cao, Yaoyu; Li, Xiangping

2017-12-01

In this Letter, we numerically demonstrate the all-optical generation of uniformly oriented in-plane magnetization with near-unity purity (more than 99%) under a 4π microscopic configuration. This is achieved through focusing two counter-propagating vector beams consisting of coherently configured linear and radial components. Based on the Debye diffraction theory, constructive and destructive interferences of the focal field components can be tailored under the 4π configuration to generate high-purity uniformly polarized transverse and longitudinal electric-field components in the center of the focal region. Consequently, near-unity purity in-plane magnetization with a uniform orientation within the focal volume defined by the full width at half-maximum can be created through the inverse Faraday effect. In addition, it reveals that the purity of the in-plane magnetization is robust against the numerical aperture of the focal lens. This result expands the flexibility of magnetization manipulations through light and holds great potential in all-optical magnetic recording and spintronics.

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells.

PubMed

Kuijpers, Taco W; van Leeuwen, Ester M M; Barendregt, Barbara H; Klarenbeek, Paul; aan de Kerk, Daan J; Baars, Paul A; Jansen, Machiel H; de Vries, Niek; van Lier, René A W; van der Burg, Mirjam

2013-07-01

Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficiencies with a variety of clinical presentations. We analyzed peripheral blood mononuclear cells of a 6-year-old boy with normal lymphocyte counts, who suffered from recurrent pneumonia and disseminated mollusca contagiosa. Since proliferative responses of T cells and NK cells to γc -cytokines were severely impaired, we performed IL2RG gene analysis, showing a heterozygous mutation in the presence of a single X-chromosome. Interestingly, an IL2RG reversion to normal predominated in both naïve and antigen-primed CD8(+) T cells and increased over time. Only the revertant CD8(+) T cells showed normal expression of CD132 and the various CD8(+) T cell populations had a different T-cell receptor repertoire. Finally, a fraction of γδ(+) T cells and differentiated CD4(+)CD27(-) effector-memory T cells carried the reversion, whereas NK or B cells were repeatedly negative. In conclusion, in a patient with a novel IL2RG mutation, gene-reverted CD8(+) T cells accumulated over time. Our data indicate that selective outgrowth of particular T-cell subsets may occur following reversion at the level of committed T progenitor cells.

77 FR 70478 - RG Steel Wheeling, LLC, Wheeling Office, A Division Of RG Steel, LLC, Including On-Site Leased...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,880: TA-A-81,880A] RG Steel Wheeling, LLC, Wheeling Office, A Division Of RG Steel, LLC, Including On-Site Leased Workers From Pro Unlimited and Green Energy Initiatives LLC, Including Workers Whose Wages Were Reported Through Severstal Wheeling, Wheeling, WV: Mountain State...

Tertiary structural changes and iron release from human serum transferrin.

PubMed

Mecklenburg, S L; Donohoe, R J; Olah, G A

1997-08-01

Iron release from human serum transferrin was investigated by comparison of the extent of bound iron, measured by charge transfer absorption band intensity (465 nm), with changes observed by small-angle solution X-ray scattering (SAXS) for a series of equilibrated samples between pH 5.69 and 7.77. The phosphate buffers used in this study promote iron release at relatively high pH values, with an empirical pK of 6.9 for the convolved release from the two sites. The spectral data reveal that the N-lobe release is nearly complete by pH 7.0, while the C-lobe remains primarily metal-laden. Conversely, the radius of gyration, Rg, determined from the SAXS data remains constant between pH 7.77 and 7.05, and the evolution of Rg between its value observed for the diferric protein at pH 7.77 (31.2+/-0.2 A) and that of the apo protein at pH 5.69 (33.9+/-0.4 A) exhibits an empirical pK of 6.6. While Rg is effectively constant in the pH range associated with iron release from the N-lobe, the radius of gyration of cross-section, Rc, increases from 16.9+/-0.2 A to 17.6+/-0.2 A. Model simulations suggest that two different rotations of the NII domain relative to the NI domain about a hinge deep in the iron-binding cleft of the N-lobe, one parallel with and one perpendicular to the plane of the iron-binding site, can be significantly advanced relative to their holo protein positions while yielding constant Rg and increased Rc values consistent with the scattering data. Rotation of the CII domain parallel with the C-lobe iron-binding site plane can partially account for the increased Rg values measured at low pH; however, no reasonable combined repositioning of the NII and CII domains yields the experimentally observed increase in Rg.

Labeled RFS-Based Track-Before-Detect for Multiple Maneuvering Targets in the Infrared Focal Plane Array.

PubMed

Li, Miao; Li, Jun; Zhou, Yiyu

2015-12-08

The problem of jointly detecting and tracking multiple targets from the raw observations of an infrared focal plane array is a challenging task, especially for the case with uncertain target dynamics. In this paper a multi-model labeled multi-Bernoulli (MM-LMB) track-before-detect method is proposed within the labeled random finite sets (RFS) framework. The proposed track-before-detect method consists of two parts-MM-LMB filter and MM-LMB smoother. For the MM-LMB filter, original LMB filter is applied to track-before-detect based on target and measurement models, and is integrated with the interacting multiple models (IMM) approach to accommodate the uncertainty of target dynamics. For the MM-LMB smoother, taking advantage of the track labels and posterior model transition probability, the single-model single-target smoother is extended to a multi-model multi-target smoother. A Sequential Monte Carlo approach is also presented to implement the proposed method. Simulation results show the proposed method can effectively achieve tracking continuity for multiple maneuvering targets. In addition, compared with the forward filtering alone, our method is more robust due to its combination of forward filtering and backward smoothing.

Labeled RFS-Based Track-Before-Detect for Multiple Maneuvering Targets in the Infrared Focal Plane Array

PubMed Central

Li, Miao; Li, Jun; Zhou, Yiyu

2015-01-01

The problem of jointly detecting and tracking multiple targets from the raw observations of an infrared focal plane array is a challenging task, especially for the case with uncertain target dynamics. In this paper a multi-model labeled multi-Bernoulli (MM-LMB) track-before-detect method is proposed within the labeled random finite sets (RFS) framework. The proposed track-before-detect method consists of two parts—MM-LMB filter and MM-LMB smoother. For the MM-LMB filter, original LMB filter is applied to track-before-detect based on target and measurement models, and is integrated with the interacting multiple models (IMM) approach to accommodate the uncertainty of target dynamics. For the MM-LMB smoother, taking advantage of the track labels and posterior model transition probability, the single-model single-target smoother is extended to a multi-model multi-target smoother. A Sequential Monte Carlo approach is also presented to implement the proposed method. Simulation results show the proposed method can effectively achieve tracking continuity for multiple maneuvering targets. In addition, compared with the forward filtering alone, our method is more robust due to its combination of forward filtering and backward smoothing. PMID:26670234

The effect of recycled Natural Rubber Glove (rRG) Plasticizers to Deflection and Flexural Strength Properties of PP/MMt/rRG Smart Composites and Its Inflammability

NASA Astrophysics Data System (ADS)

Suharty, N. S.; Ismail, H.; Diharjo, K.; Handayani, D. S.; Saputri, L. N. M. Z.; Ariesta, N.

2018-03-01

Had been synthesized PP/rRG/MMt+ZB smart material composite in solution reactive processes with various rRG concentration. The addition of rRG plasticizers will improve the deflection properties and increase the filler capacity MMt loading to reach the optimum concentration. The addition of 3% rRG is capable of loading filler capacity MMt to 23% as the optimum condition. At the optimum conditions it can increase the deflection (Defl) and flexural strength (FS) up to 16% and 15% respectively compared to that of the composites without rRG. The rRG plasticizer serves as a bio-compatibilizer that can reduce surface tension of the mixture and leads to decrease the Defl., follow by the increase of loading filler capacity and well interaction finally can increase the FS properties. The increase of loading filler MMt up to 23% can also improve the inflammability of the composites. Time to Ignition (TTI) increase by 5% and Burning Rate (BR) decrease by 4.5% compared to that of the composites which is containing MMt 20% without rRG.

On-sky performance evaluation and calibration of a polarization-sensitive focal plane array

NASA Astrophysics Data System (ADS)

Vorobiev, Dmitry; Ninkov, Zoran; Brock, Neal; West, Ray

2016-07-01

The advent of pixelated micropolarizer arrays (MPAs) has facilitated the development of polarization-sensitive focal plane arrays (FPAs) based on charge-coupled devices (CCDs) and active pixel sensors (APSs), which are otherwise only able to measure the intensity of light. Polarization sensors based on MPAs are extremely compact, light-weight, mechanically robust devices with no moving parts, capable of measuring the degree and angle of polarization of light in a single snapshot. Furthermore, micropolarizer arrays based on wire grid polarizers (so called micro-grid polarizers) offer extremely broadband performance, across the optical and infrared regimes. These devices have potential for a wide array of commercial and research applications, where measurements of polarization can provide critical information, but where conventional polarimeters could be practically implemented. To date, the most successful commercial applications of these devices are 4D Technology's PhaseCam laser interferometers and PolarCam imaging polarimeters. Recently, MPA-based polarimeters have been identified as a potential solution for space-based telescopes, where the small size, snapshot capability and low power consumption (offered by these devices) are extremely desirable. In this work, we investigated the performance of MPA-based polarimeters designed for astronomical polarimetry using the Rochester Institute of Technology Polarization Imaging Camera (RITPIC). We deployed RITPIC on the 0.9 meter SMARTS telescope at the Cerro Tololo Inter-American Observatory and observed a variety of astronomical objects (calibration stars, variable stars, reflection nebulae and planetary nebulae). We use our observations to develop calibration procedures that are unique to these devices and provide an estimate for polarimetric precision that is achievable.

Focal plane arrays based on Type-II indium arsenide/gallium antimonide superlattices

NASA Astrophysics Data System (ADS)

Delaunay, Pierre-Yves

The goal of this work is to demonstrate that Type-II InAs/GaSb superlattices can perform high quality infrared imaging from the middle (MWIR) to the long (LWIR) wavelength infrared range. Theoretically, focal plane arrays (FPAs) based on this technology could be operated at higher temperatures, with lower dark currents than the leading HgCdTe platform. This effort will focus on the fabrication of MWIR and LWIR FPAs with performance similar to existing infrared cameras. Some applications in the MWIR require fast, sensitive imagers able to sustain frame rates up to 100Hz. Such speed can only be achieved with photon detectors. However, these cameras need to be operated below 170K. Current research in this spectral band focuses on increasing the operating temperature of the FPA to a point where cooling could be performed with compact and reliable thermoelectric coolers. Type-II superlattice was used to demonstrate a camera that presented similar performance to HgCdTe and that could be operated up to room temperature. At 80K, the camera could detect temperature differences as low as 10 mK for an integration time shorter than 25 ms. In the LWIR, the electric performance of Type-II photodiodes is mainly limited by surface leakage. Aggressive processing steps such as hybridization and underfill can increase the dark current of the devices by several orders of magnitude. New cleaning and passivation techniques were used to reduce the dark current of FPA diodes by two orders of magnitudes. The absorbing GaSb substrate was also removed to increase the quantum efficiency of the devices up to 90%. At 80K, a FPA with a 9.6 microm 50%-cutoff in responsivity was able to detect temperature differences as low as 19 mK, only limited by the performance of the testing system. The non-uniformity in responsivity reached 3.8% for a 98.2% operability. The third generation of infrared cameras is based on multi-band imaging in order to improve the recognition capabilities of the imager

Development of Ultra-Low Noise, High Sensitivity Planar Metal Grating Coupled AlGaAs/GaAs Multiquantum Well IR Detectors for Focal Plane Array Staring IR Sensor Systems

DTIC Science & Technology

1992-02-01

Development of Ultra-Low Noise , High Sensitivity Planar Metal Grating Coupled AlGaAs/GaAs Multiquantum Well IR Detectors for Focal Plane Array Staring IR...dark current at 77 K was 10 times lower than the conventional QWIP reported in the literature. anid the BTM QWIP showed a largely enhanced intersubband...bias voltage in the BTM and SBTM1 QWIPs . The results reveal thiat therinionic emission is dominant current conduction mechianismn at higher temp

Focal-Plane Arrays of Quantum-Dot Infrared Photodetectors

NASA Technical Reports Server (NTRS)

Gunapala, Sarath; Wilson, Daniel; Hill, Cory; Liu, John; Bandara, Sumith; Ting, David

2007-01-01

Focal-plane arrays of semiconductor quantum-dot infrared photodetectors (QDIPs) are being developed as superior alternatives to prior infrared imagers, including imagers based on HgCdTe devices and, especially, those based on quantum-well infrared photodetectors (QWIPs). HgCdTe devices and arrays thereof are difficult to fabricate and operate, and they exhibit large nonunformities and high 1/f (where f signifies frequency) noise. QWIPs are easier to fabricate and operate, can be made nearly uniform, and exhibit lower 1/f noise, but they exhibit larger dark currents, and their quantization only along the growth direction prevents them from absorbing photons at normal incidence, thereby limiting their quantum efficiencies. Like QWIPs, QDIPs offer the advantages of greater ease of operation, greater uniformity, and lower 1/f noise, but without the disadvantages: QDIPs exhibit lower dark currents, and quantum efficiencies of QDIPs are greater because the three-dimensional quantization of QDIPs is favorable to the absorption of photons at normal or oblique incidence. Moreover, QDIPs can be operated at higher temperatures (around 200 K) than are required for operation of QWIPs. The main problem in the development of QDIP imagers is to fabricate quantum dots with the requisite uniformity of size and spacing. A promising approach to be tested soon involves the use of electron-beam lithography to define the locations and sizes of quantum dots. A photoresist-covered GaAs substrate would be exposed to the beam generated by an advanced, high-precision electron beam apparatus. The exposure pattern would consist of spots typically having a diameter of 4 nm and typically spaced 20 nm apart. The exposed photoresist would be developed by either a high-contrast or a low-contrast method. In the high-contrast method, the spots would be etched in such a way as to form steep-wall holes all the way down to the substrate. The holes would be wider than the electron beam spots perhaps as

Translocation of TRPV2 channel induced by focal administration of mechanical stress

PubMed Central

Nagasawa, Masahiro; Kojima, Itaru

2015-01-01

The effect of focal mechanical stress on the localization of TRPV2 was investigated in HT1080 cells, where only mRNA for TRPV2 was detected among members of the TRPV channel family. Mechanical stress was applied by adding negative pressure using a glass pipette. When focal mechanical stress was applied, subplasma membrane Ca2+ concentration ([Ca2+]s) was increased beneath the pipette, which propagated throughout the cell. The increase in [Ca2+]s was blocked by ruthenium red or by knocking down TRPV2. Elevation of [Ca2+]s was not observed by removal of extracellular Ca2+, by an addition of a phosphatidylinositol 3-kinase inhibitor LY29034, and by transfection of dominant-negative Rac. In cells expressing GFP-TRPV2 and RFP-Akt, administration of focal mechanical stress induced accumulation of GFP-TRPV2 beneath the pipette. RFP-Akt was also accumulated to the same site. Gadolinium blocked the elevation of [Ca2+]s induced by focal mechanical stress and also attenuated accumulation of TRPV2. When GFP-TRPV1, GFP-TRPV3, GFP-TRPV4, GFP-TRPV5, or GFP-TRPV6 was transfected ectopically in HT1080 cells, only GFP-TRPV4 was accumulated beneath the pipette in response to the focal mechanical stress. These results indicate that TRPV2 translocates to the site receiving a focal mechanical stress and increases [Ca2+]s. PMID:25677550

Design and performance of single photon APD focal plane arrays for 3-D LADAR imaging

NASA Astrophysics Data System (ADS)

Itzler, Mark A.; Entwistle, Mark; Owens, Mark; Patel, Ketan; Jiang, Xudong; Slomkowski, Krystyna; Rangwala, Sabbir; Zalud, Peter F.; Senko, Tom; Tower, John; Ferraro, Joseph

2010-08-01

×We describe the design, fabrication, and performance of focal plane arrays (FPAs) for use in 3-D LADAR imaging applications requiring single photon sensitivity. These 32 × 32 FPAs provide high-efficiency single photon sensitivity for three-dimensional LADAR imaging applications at 1064 nm. Our GmAPD arrays are designed using a planarpassivated avalanche photodiode device platform with buried p-n junctions that has demonstrated excellent performance uniformity, operational stability, and long-term reliability. The core of the FPA is a chip stack formed by hybridizing the GmAPD photodiode array to a custom CMOS read-out integrated circuit (ROIC) and attaching a precision-aligned GaP microlens array (MLA) to the back-illuminated detector array. Each ROIC pixel includes an active quenching circuit governing Geiger-mode operation of the corresponding avalanche photodiode pixel as well as a pseudo-random counter to capture per-pixel time-of-flight timestamps in each frame. The FPA has been designed to operate at frame rates as high as 186 kHz for 2 μs range gates. Effective single photon detection efficiencies as high as 40% (including all optical transmission and MLA losses) are achieved for dark count rates below 20 kHz. For these planar-geometry diffused-junction GmAPDs, isolation trenches are used to reduce crosstalk due to hot carrier luminescence effects during avalanche events, and we present details of the crosstalk performance for different operating conditions. Direct measurement of temporal probability distribution functions due to cumulative timing uncertainties of the GmAPDs and ROIC circuitry has demonstrated a FWHM timing jitter as low as 265 ps (standard deviation is ~100 ps).

Fault-slip directions in central and southern Greece measured from striated and corrugated fault planes: Comparison with focal mechanism and geodetic data

NASA Astrophysics Data System (ADS)

Roberts, Gerald P.; Ganas, Athanassios

2000-10-01

Fault-slip directions recorded by outcropping striated and corrugated fault planes in central and southern Greece have been measured for comparison with extension directions derived from focal mechanism and Global Positioning System (GPS) data for the last ˜100 years to test how far back in time velocity fields and deformation dynamics derived from the latter data sets can be extrapolated. The fault-slip data have been collected from the basin-bounding faults to Plio-Pleistocene to recent extensional basins and include data from arrays of footwall faults formed during the early stages of fault growth. We show that the orientation of the inferred stress field varies along faults and earthquake ruptures, so we use only slip-directions from the centers of faults, where dip-slip motion occurs, to constrain regionally significant extension directions. The fault-slip directions for the Peloponnese and Gulfs of Evia and Corinth are statistically different at the 99% confidence level but statistically the same as those implied by earthquake focal mechanisms for each region at the 99% confidence level; they are also qualitatively similar to the principal strain axes derived from GPS studies. Extension directions derived from fault-slip data are 043-047° for the southern Peloponnese, 353° for the Gulf of Corinth, and 015-014° for the Gulf of Evia. Extension on active normal faults in the two latter areas appears to grade into strike-slip along the North Anatolian Fault through a gradual change in fault-slip directions and fault strikes. To reconcile the above with 5° Myr-1 clockwise rotations suggested for the area, we suggest that the faults considered formed during a single phase of extension. The deformation and formation of the normal fault systems examined must have been sufficiently rapid and recent for rotations about vertical axes to have been unable to disperse the fault-slip directions from the extension directions implied by focal mechanisms and GPS data

Yang Baxter and anisotropic sigma and lambda models, cyclic RG and exact S-matrices

NASA Astrophysics Data System (ADS)

Appadu, Calan; Hollowood, Timothy J.; Price, Dafydd; Thompson, Daniel C.

2017-09-01

Integrable deformation of SU(2) sigma and lambda models are considered at the classical and quantum levels. These are the Yang-Baxter and XXZ-type anisotropic deformations. The XXZ type deformations are UV safe in one regime, while in another regime, like the Yang-Baxter deformations, they exhibit cyclic RG behaviour. The associ-ated affine quantum group symmetry, realized classically at the Poisson bracket level, has q a complex phase in the UV safe regime and q real in the cyclic RG regime, where q is an RG invariant. Based on the symmetries and RG flow we propose exact factorizable S-matrices to describe the scattering of states in the lambda models, from which the sigma models follow by taking a limit and non-abelian T-duality. In the cyclic RG regimes, the S-matrices are periodic functions of rapidity, at large rapidity, and in the Yang-Baxter case violate parity.

Focal-plane detector system for the KATRIN experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amsbaugh, J. F.; Barrett, J.; Beglarian, A.

Here, the local plane detector system for the KArlsiuhe TRItium Neutrino (KATRIN) experiment consists of a multi-pixel silicon p-i-n-diode array, custom readout electronics, two superconducting solenoid magnets, an ultra high vacuum system, a high vacuum system, calibration and monitoring devices, a scintillating veto, and a custom data-acquisition system, It is designed to detect the low-energy electrons selected by the KATRIN main spectrometer. We describe the system and summarize its performance after its final installation.

Focal-plane detector system for the KATRIN experiment

DOE PAGES

Amsbaugh, J. F.; Barrett, J.; Beglarian, A.; ...

2015-01-09

Here, the local plane detector system for the KArlsiuhe TRItium Neutrino (KATRIN) experiment consists of a multi-pixel silicon p-i-n-diode array, custom readout electronics, two superconducting solenoid magnets, an ultra high vacuum system, a high vacuum system, calibration and monitoring devices, a scintillating veto, and a custom data-acquisition system, It is designed to detect the low-energy electrons selected by the KATRIN main spectrometer. We describe the system and summarize its performance after its final installation.

An inverter-based capacitive trans-impedance amplifier readout with offset cancellation and temporal noise reduction for IR focal plane array

NASA Astrophysics Data System (ADS)

Chen, Hsin-Han; Hsieh, Chih-Cheng

2013-09-01

This paper presents a readout integrated circuit (ROIC) with inverter-based capacitive trans-impedance amplifier (CTIA) and pseudo-multiple sampling technique for infrared focal plane array (IRFPA). The proposed inverter-based CTIA with a coupling capacitor [1], executing auto-zeroing technique to cancel out the varied offset voltage from process variation, is used to substitute differential amplifier in conventional CTIA. The tunable detector bias is applied from a global external bias before exposure. This scheme not only retains stable detector bias voltage and signal injection efficiency, but also reduces the pixel area as well. Pseudo-multiple sampling technique [2] is adopted to reduce the temporal noise of readout circuit. The noise reduction performance is comparable to the conventional multiple sampling operation without need of longer readout time proportional to the number of samples. A CMOS image sensor chip with 55×65 pixel array has been fabricated in 0.18um CMOS technology. It achieves a 12um×12um pixel size, a frame rate of 72 fps, a power-per-pixel of 0.66uW/pixel, and a readout temporal noise of 1.06mVrms (16 times of pseudo-multiple sampling), respectively.

Influence of stimulus size on revealing non-cardinal color mechanisms.

PubMed

Gunther, Karen L; Downey, Colin O

2016-10-01

Multiple studies have shown that performance of subjects on a number of visual tasks is worse for non-cardinal than cardinal colors, especially in the red-green/luminance (RG/LUM) and tritan/luminance (TRIT/LUM) color planes. Inspired by neurophysiological evidence that suppressive surround input to receptive fields is particularly sensitive to luminance, we hypothesized that non-cardinal mechanisms in the RG/LUM and TRIT/LUM planes would be more sensitive to stimulus size than are isoluminant non-cardinal mechanisms. In Experiment 1 we tested 9-10 color-normal subjects in each of the three color planes (RG/TRIT, RG/LUM, and TRIT/LUM) on visual search at four bull's-eye dot sizes (0.5°/1°, 1°/2°, 2°/4°, and 3°/6° center/annulus dot diameter). This study yielded a significant main effect of dot size in each of the three color planes. In Experiment 2 we tested the same hypothesis using noise masking, at three stimulus sizes (3°, 6° and 9° diameter Gabors), again in all three color planes (5 subjects per color plane). This experiment yielded, in the RG/TRIT plane, a significant main effect of stimulus size; in the RG/LUM plane, significant evidence for non-cardinal mechanisms only for the 9° stimulus; but in the TRIT/LUM plane no evidence for non-cardinal mechanisms at any stimulus size. These results suggest that non-cardinal mechanisms, particularly in the RG/LUM color plane, are more sensitive to stimulus size than are non-cardinals in the RG/TRIT plane, supporting our hypothesis. Copyright © 2016 Elsevier Ltd. All rights reserved.

A modified method for determining the focal ratio degradation and length properties of optical fibres in astronomy

NASA Astrophysics Data System (ADS)

Yan, Yunxiang; Wang, Gang; Sun, Weimin; Luo, A.-Li; Ma, Zhenyu; Li, Jian; Wang, Shuqing

2017-04-01

Focal ratio degradation (FRD) is a major contributor to throughput and light loss in a fibre spectroscopic telescope system. We combine the guided mode theory in geometric optics and a well-known model, the power distribution model (PDM), to predict and explain the FRD dependence properties. We present a robust method by modifying the energy distribution method with f-intercept to control the input condition. This method provides a way to determine the proper position of the fibre end on the focal plane to improve energy utilization and FRD performance, which lifts the relative throughput up to 95 per cent with variation of output focal ratio less than 2 per cent. This method can also help to optimize the arrangement of the position of focal-plane plate to enhance the coupling efficiency in a telescope. To investigate length properties, we modified the PDM by introducing a new parameter, the focal distance f, into the original model to make it available for a multiposition measurement system. The results show that the modified model is robust and feasible for measuring the key parameter d0 to simulate the transmission characteristics. The output focal ratio in the experiment does not follow the prediction trend but shows an interesting phenomenon: the output focal ratio increases first to the peak, then decreases and remains stable finally with increasing fibre length longer than 15 m. This provides a reference for choosing the appropriate length of fibre to improve the FRD performance for the design of the fibre system in a telescope.

The DcpS inhibitor RG3039 improves motor function in SMA mice

PubMed Central

Van Meerbeke, James P.; Gibbs, Rebecca M.; Plasterer, Heather L.; Miao, Wenyan; Feng, Zhihua; Lin, Ming-Yi; Rucki, Agnieszka A.; Wee, Claribel D.; Xia, Bing; Sharma, Shefali; Jacques, Vincent; Li, Darrick K.; Pellizzoni, Livio; Rusche, James R.; Ko, Chien-Ping; Sumner, Charlotte J.

2013-01-01

Spinal muscular atrophy (SMA) is caused by mutations of the survival motor neuron 1 (SMN1) gene, retention of the survival motor neuron 2 (SMN2) gene and insufficient expression of full-length survival motor neuron (SMN) protein. Quinazolines increase SMN2 promoter activity and inhibit the ribonucleic acid scavenger enzyme DcpS. The quinazoline derivative RG3039 has advanced to early phase clinical trials. In preparation for efficacy studies in SMA patients, we investigated the effects of RG3039 in severe SMA mice. Here, we show that RG3039 distributed to central nervous system tissues where it robustly inhibited DcpS enzyme activity, but minimally activated SMN expression or the assembly of small nuclear ribonucleoproteins. Nonetheless, treated SMA mice showed a dose-dependent increase in survival, weight and motor function. This was associated with improved motor neuron somal and neuromuscular junction synaptic innervation and function and increased muscle size. RG3039 also enhanced survival of conditional SMA mice in which SMN had been genetically restored to motor neurons. As this systemically delivered drug may have therapeutic benefits that extend beyond motor neurons, it could act additively with SMN-restoring therapies delivered directly to the central nervous system such as antisense oligonucleotides or gene therapy. PMID:23727836

The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models

PubMed Central

Gogliotti, Rocky G.; Cardona, Herminio; Singh, Jasbir; Bail, Sophie; Emery, Carina; Kuntz, Nancy; Jorgensen, Michael; Durens, Madel; Xia, Bing; Barlow, Courtenay; Heier, Christopher R.; Plasterer, Heather L.; Jacques, Vincent; Kiledjian, Megerditch; Jarecki, Jill; Rusche, James; DiDonato, Christine J.

2013-01-01

Spinal muscular atrophy (SMA) is caused by insufficient levels of the survival motor neuron (SMN) protein due to the functional loss of the SMN1 gene and the inability of its paralog, SMN2, to fully compensate due to reduced exon 7 splicing efficiency. Since SMA patients have at least one copy of SMN2, drug discovery campaigns have sought to identify SMN2 inducers. C5-substituted quinazolines increase SMN2 promoter activity in cell-based assays and a derivative, RG3039, has progressed to clinical testing. It is orally bioavailable, brain-penetrant and has been shown to be an inhibitor of the mRNA decapping enzyme, DcpS. Our pharmacological characterization of RG3039, reported here, demonstrates that RG3039 can extend survival and improve function in two SMA mouse models of varying disease severity (Taiwanese 5058 Hemi and 2B/− SMA mice), and positively impacts neuromuscular pathologies. In 2B/− SMA mice, RG3039 provided a >600% survival benefit (median 18 days to >112 days) when dosing began at P4, highlighting the importance of early intervention. We determined the minimum effective dose and the associated pharmacokinetic (PK) and exposure relationship of RG3039 and DcpS inhibition ex vivo. These data support the long PK half-life with extended pharmacodynamic outcome of RG3039 in 2B/− SMA mice. In motor neurons, RG3039 significantly increased both the average number of cells with gems and average number of gems per cell, which is used as an indirect measure of SMN levels. These studies contribute to dose selection and exposure estimates for the first studies with RG3039 in human subjects. PMID:23736298

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells

PubMed Central

Kuijpers, Taco W.; van Leeuwen, Ester M.M.; Barendregt, Barbara H.; Klarenbeek, Paul; aan de Kerk, Daan J.; Baars, Paul A.; Jansen, Machiel H.; de Vries, Niek; van Lier, René A.W.; van der Burg, Mirjam

2013-01-01

Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B+T−NK− X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficiencies with a variety of clinical presentations. We analyzed peripheral blood mononuclear cells of a 6-year-old boy with normal lymphocyte counts, who suffered from recurrent pneumonia and disseminated mollusca contagiosa. Since proliferative responses of T cells and NK cells to γc -cytokines were severely impaired, we performed IL2RG gene analysis, showing a heterozygous mutation in the presence of a single X-chromosome. Interestingly, an IL2RG reversion to normal predominated in both naïve and antigen-primed CD8+ T cells and increased over time. Only the revertant CD8+ T cells showed normal expression of CD132 and the various CD8+ T cell populations had a different T-cell receptor repertoire. Finally, a fraction of γδ+ T cells and differentiated CD4+CD27− effector-memory T cells carried the reversion, whereas NK or B cells were repeatedly negative. In conclusion, in a patient with a novel IL2RG mutation, gene-reverted CD8+ T cells accumulated over time. Our data indicate that selective outgrowth of particular T-cell subsets may occur following reversion at the level of committed T progenitor cells. PMID:23403317

Translocation of TRPV2 channel induced by focal administration of mechanical stress.

PubMed

Nagasawa, Masahiro; Kojima, Itaru

2015-02-01

The effect of focal mechanical stress on the localization of TRPV2 was investigated in HT1080 cells, where only mRNA for TRPV2 was detected among members of the TRPV channel family. Mechanical stress was applied by adding negative pressure using a glass pipette. When focal mechanical stress was applied, subplasma membrane Ca(2+) concentration ([Ca(2+)]s) was increased beneath the pipette, which propagated throughout the cell. The increase in [Ca(2+)]s was blocked by ruthenium red or by knocking down TRPV2. Elevation of [Ca(2+)]s was not observed by removal of extracellular Ca(2+), by an addition of a phosphatidylinositol 3-kinase inhibitor LY29034, and by transfection of dominant-negative Rac. In cells expressing GFP-TRPV2 and RFP-Akt, administration of focal mechanical stress induced accumulation of GFP-TRPV2 beneath the pipette. RFP-Akt was also accumulated to the same site. Gadolinium blocked the elevation of [Ca(2+)]s induced by focal mechanical stress and also attenuated accumulation of TRPV2. When GFP-TRPV1, GFP-TRPV3, GFP-TRPV4, GFP-TRPV5, or GFP-TRPV6 was transfected ectopically in HT1080 cells, only GFP-TRPV4 was accumulated beneath the pipette in response to the focal mechanical stress. These results indicate that TRPV2 translocates to the site receiving a focal mechanical stress and increases [Ca(2+)]s. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Development of Ultra-Low Noise, High Sensitivity Planar Metal Grating Coupled AlGaAs/GaAs Multiquantum Well IR Detectors for Focal Plane Array Staring IR Sensor Systems

DTIC Science & Technology

1992-05-01

Development of Ultra-Low Noise , High Sensitivity Planar Metal Grating Coupled AlGaAs/GaAs Multiquantum Well IR Detectors for Focal Plane Array...February 1 - April 30, 1992 Project Title: Development of low- noise high-detectivity planar metal grating coupled III-V multiquantum-well/superlattice...low- noise and high-detectivity planar metal grating coupled bound-to- miniband (BTM) GaAs/AlGaAs and step-bound-to-miniband (SBTM) InGaAs/AlGaAs /GaAs

Photoabsorption and photoionization cross sections of NH3, PH3, H2S, C2H2, and C2H4 in the VUV region

NASA Technical Reports Server (NTRS)

Xia, T. J.; Chien, T. S.; Wu, C. Y. Robert; Judge, D. L.

1991-01-01

Using synchrotron radiation as a continuum light source, the photoabsorption and photoionization cross sections of NH3, PH3, H2S, C2H2, and C2H4 have been measured from their respective ionization thresholds to 1060 A. The vibrational constants associated with the nu(2) totally symmetric, out-of-plane bending vibration of the ground electronic state of PH3(+) have been obtained. The cross sections and quantum yields for producing neutral products through photoexcitation of these molecules in the given spectral regions have also been determined. In the present work, autoionization processes were found to be less important than dissociation and predissociation processes in NH3, PH3, and C2H4. Several experimental techniques have been employed in order to examine the various possible systematic errors critically.

A pipelined architecture for real time correction of non-uniformity in infrared focal plane arrays imaging system using multiprocessors

NASA Astrophysics Data System (ADS)

Zou, Liang; Fu, Zhuang; Zhao, YanZheng; Yang, JunYan

2010-07-01

This paper proposes a kind of pipelined electric circuit architecture implemented in FPGA, a very large scale integrated circuit (VLSI), which efficiently deals with the real time non-uniformity correction (NUC) algorithm for infrared focal plane arrays (IRFPA). Dual Nios II soft-core processors and a DSP with a 64+ core together constitute this image system. Each processor undertakes own systematic task, coordinating its work with each other's. The system on programmable chip (SOPC) in FPGA works steadily under the global clock frequency of 96Mhz. Adequate time allowance makes FPGA perform NUC image pre-processing algorithm with ease, which has offered favorable guarantee for the work of post image processing in DSP. And at the meantime, this paper presents a hardware (HW) and software (SW) co-design in FPGA. Thus, this systematic architecture yields an image processing system with multiprocessor, and a smart solution to the satisfaction with the performance of the system.

Effects of acupuncturing Pishu combined with Ginsenoside Rg3 on the immune function of rats with chronic fatigue.

PubMed

Zhang, Wenjing; Zhang, Yue; Ma, Xiande; Chen, Yiguo

2015-01-01

This study was designed to investigate the effects of acupuncturing Pishu combined with Ginsenoside Rg3 on the immune function of rats with chronic fatigue. Forty male SD rats were equally randomized into control group, chronic fatigue system group (CFS), Ginsenoside Rg3 (Rg3) group, acupuncture group and acupuncture combined with Ginsenoside Rg3 (A+Rg3) group. Rats with chronic fatigue were established by bounding and forced swimming in cold water once daily for 21 days except control group, then the rats in the acupuncture and A+Rg3 group were treated by manual acupuncture stimulation of bilateral "Pishu" once daily for 7 days. Ginsenoside Rg3 was administered by intravenous to the rats of the A+Rg3 and Rg3 group for 7 days in dosages of 2 mg/kg body weight, and two markers of physical fatigue were evaluated: body weight and blood lactic acid (LA). The percentages of CD3(+) lymphocytes, CD4(+) lymphocytes, and CD8(+) lymphocytes in the spleens of the rats were evaluated using flow cytometric analysis. Serum IFN-gamma (IFN-γ) and IL-4 contents were detected by ELISA. Increased body weight and reduced blood LA concentrations were found in the rat of Rg3 group and A+Rg3 group than that in CFS group. The rat of Rg3 group and A+Rg3 group also showed a significant increase in the percentage of CD4(+) lymphocytes and a significant decrease in the percentage of CD8(+) lymphocytes and correct CD4(+)/CD8(+) ratio. Compared with the CFS group, the level of IFN-γ in the Rg3, acupuncture and A+Rg3 groups was reduced and IL-4 was increased. Acupuncture and Rg3 can improve the immune system activity of CFS rats and acupuncturing Pishu combined with Rg3 was significantly superior compared with Rg3 and acupuncture, respectively.

Pristine Basal- and Edge-Plane-Oriented Molybdenite MoS2 Exhibiting Highly Anisotropic Properties.

PubMed

Tan, Shu Min; Ambrosi, Adriano; Sofer, Zdenĕk; Huber, Štěpán; Sedmidubský, David; Pumera, Martin

2015-05-04

The layered structure of molybdenum disulfide (MoS2 ) is structurally similar to that of graphite, with individual sheets strongly covalently bonded within but held together through weak van der Waals interactions. This results in two distinct surfaces of MoS2 : basal and edge planes. The edge plane was theoretically predicted to be more electroactive than the basal plane, but evidence from direct experimental comparison is elusive. Herein, the first study comparing the two surfaces of MoS2 by using macroscopic crystals is presented. A careful investigation of the electrochemical properties of macroscopic MoS2 pristine crystals with precise control over the exposure of one plane surface, that is, basal plane or edge plane, was performed. These crystals were characterized thoroughly by AFM, Raman spectroscopy, X-ray photoelectron spectroscopy, voltammetry, digital simulation, and DFT calculations. In the Raman spectra, the basal and edge planes show anisotropy in the preferred excitation of E2g and A1g phonon modes, respectively. The edge plane exhibits a much larger heterogeneous electron transfer rate constant k(0) of 4.96×10(-5) and 1.1×10(-3)  cm s(-1) for [Fe(CN)6 ](3-/4-) and [Ru(NH3 )6 ](3+/2+) redox probes, respectively, compared to the basal plane, which yielded k(0) tending towards zero for [Fe(CN)6 ](3-/4-) and about 9.3×10(-4)  cm s(-1) for [Ru(NH3 )6 ](3+/2+) . The industrially important hydrogen evolution reaction follows the trend observed for [Fe(CN)6 ](3-/4-) in that the basal plane is basically inactive. The experimental comparison of the edge and basal planes of MoS2 crystals is supported by DFT calculations. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Angiotensin II effects on ischemic focal ventricular tachycardia are predominantly mediated through myocardial AT(2) receptor.

PubMed

Gopinathannair, Rakesh; Chaudhary, Ashok K; Xing, Dezhi; Ely, Debra; Zheng, Wei; Martins, James B

2009-11-01

Ischemic focal ventricular tachycardia (VT) occurs in animals and humans. Angiotensin-converting enzyme inhibitors and receptor blockers reduce sudden death in patients with ischemic heart disease. In our dog model of coronary artery occlusion (CAO), we tested the hypothesis that angiotensin II (AGII) will selectively promote focal VT and that the specific AT(2) blocker PD-123319 (PD), or AT(1) blocker losartan, will affect this VT. Anesthetized dogs (n = 90) underwent CAO, followed by three-dimensional activation mapping of inducible VT. Dogs without VT in 1-3 h after CAO received AGII, and those with VT received either PD or losartan. Focal endocardium excised from ischemic sites was studied in vitro with standard microelectrode. Of 33 dogs with no inducible VT, AGII infusion resulted in sustained VT of only focal Purkinje origin in 13 (39%) compared with 0 of 20 dogs with saline. Of 26 dogs with inducible VT at baseline, given PD, reinduction was blocked in 8 of 10 (P < 0.05) focal VT, but only 1 of 15 with reentry. In contrast, of 11 dogs given losartan, reinduction of either mechanism was not blocked. In vitro triggered activity in Purkinje was blocked by PD in 13 of 19 (P < 0.05), but not by losartan in 8. Also, triggered activity was promoted by AGII, losartan, or the combination in 9 of 12 tissues. AGII promotes only focal, mainly Purkinje ischemic VT. PD, but not losartan, preferentially blocked focal VT, which is likely due to triggered activity due to delayed afterdepolarizations in Purkinje.

Impact of Τh1 and Τh2 cytokines in the progression of idiopathic nephrotic syndrome due to focal segmental glomerulosclerosis and minimal change disease.

PubMed

Stangou, Maria; Spartalis, Μichael; Daikidou, Dimitra-Vasilia; Kouloukourgiotou, Theodora; Sampani, Erasmia; Lambropoulou, Ioanna-Theologia; Pantzaki, Afroditi; Papagianni, Αikaterini; Efstratiadis, George

2017-07-01

Differential diagnosis between primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is sometimes difficult as nephrotic syndrome is the main clinical symptom in both diseases. This study has attempted to evaluate the urinary excretion of Th1 and Th2 cytokines as potential biomarkers in distinguishing the two types of nephrotic syndrome, and predicting outcome of renal function. Thirty-six patients with FSGS (M/F 22/14, Age; 41.9 ± 17 years, SCr=1.7 ± 0.8 mg/dL, UProt=4.7 ± 5.5 g/24 h), and 21 with MCD (M/F 5/16, Age; 41.4 ± 15 years, SCr = 1 ± 0.4 mg/dL, UProt = 7.9 ± 9.3 g/24 h) were included in the study. Τh1 (IL-2, IL-12, GM-CSF, INF-γ, TNF-α) and Th2 cytokines (IL-4, IL-5, IL-10, IL-13) were measured by multiple cytokine assay, Luminex technology, in first morning urinary samples collected at the day of renal biopsy. No significant differences in urinary excretion of all cytokines were found between FSGS and MCD patients. In FSGS however, IL-12 urinary levels were independent factor correlated with both global sclerosis (R = 0.5, P = 0.009) and interstitial fibrosis (R = 0.5, P = 0.02). Th1 cytokines (IL-2 and GM-CSF) were significantly increased in FSGS patients who did not respond to treatment ( P = 0.03 and P = 0.007, respectively). Th2 cytokines (IL-4, IL-5, IL-10, IL-13) were significantly increased in MCD patients with frequent relapses ( P = 0.05, P = 0.001, P = 0.01, P = 0.03). Urinary excretion of Th1 and Th2 cytokines cannot discriminate FSGS from MCD. Th1 cytokines, especially IL-12, IL-2 and GM-CSF, may be involved in pathology and progression of FSGS, while Th2 cytokines are implicated in frequent relapses of nephrotic syndrome in MCD.

Activating and optimizing MoS 2 basal planes for hydrogen evolution through the formation of strained sulphur vacancies

DOE PAGES

Li, Hong; Tsai, Charlie; Koh, Ai Leen; ...

2015-11-09

As a promising non-precious catalyst for the hydrogen evolution reaction, molybdenum disulphide (MoS 2) is known to contain active edge sites and an inert basal plane. Activating the MoS 2 basal plane could further enhance its HER activity but is not often a strategy for doing so. Herein, we report the first activation and optimization of the basal plane of monolayer 2H-MoS 2 for HER by introducing sulphur (S) vacancies and strain. Our theoretical and experimental results show that the S-vacancies are new catalytic sites in the basal plane, where gap states around the Fermi level allow hydrogen to bindmore » directly to exposed Mo atoms. The hydrogen adsorption free energy (ΔG H) can be further manipulated by straining the surface with S-vacancies, which fine-tunes the catalytic activity. Furthermore, proper combinations of S-vacancy and strain yield the optimal ΔG H = 0 eV, which allows us to achieve the highest intrinsic HER activity among molybdenum-sulphide-based catalysts.« less

Cross-protective efficacies of highly-pathogenic avian influenza H5N1 vaccines against a recent H5N8 virus.

PubMed

Park, Su-Jin; Si, Young-Jae; Kim, Jihye; Song, Min-Suk; Kim, Se-Mi; Kim, Eun-Ha; Kwon, Hyeok-Il; Kim, Young-Il; Lee, Ok-Jun; Shin, Ok Sarah; Kim, Chul-Joong; Shin, Eui-Cheol; Choi, Young Ki

2016-11-01

To investigate cross-protective vaccine efficacy of highly-pathogenic avian influenza H5N1 viruses against a recent HPAI H5N8 virus, we immunized C57BL/6 mice and ferrets with three alum-adjuvanted inactivated whole H5N1 vaccines developed through reverse-genetics (Rg): [Vietnam/1194/04xPR8 (clade 1), Korea/W149/06xPR8 (clade 2.2), and Korea/ES223N/03xPR8 (clade 2.5)]. Although relatively low cross-reactivities (10-40 HI titer) were observed against heterologous H5N8 virus, immunized animals were 100% protected from challenge with the 20 mLD50 of H5N8 virus, with the exception of mice vaccinated with 3.5μg of Rg Vietnam/1194/04xPR8. Of note, the Rg Korea/ES223N/03xPR8 vaccine provided not only effective protection, but also markedly inhibited viral replication in the lungs and nasal swabs of vaccine recipients within five days of HPAI H5N8 virus challenge. Further, we demonstrated that antibody-dependent cell-mediated cytotoxicity (ADCC) of an antibody-coated target cell by cytotoxic effector cells also plays a role in the heterologous protection of H5N1 vaccines against H5N8 challenge. Copyright © 2016 Elsevier Inc. All rights reserved.

Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

PubMed Central

Ishida, Julie H.; Patel, Anita; Mehta, Aneesh K.; Gatault, Philippe; McBride, Jacqueline M.; Burgess, Tracy; Derby, Michael A.; Snydman, David R.; Emu, Brinda; Feierbach, Becket; Fouts, Ashley E.; Maia, Mauricio; Deng, Rong; Rosenberger, Carrie M.; Gennaro, Lynn A.; Striano, Natalee S.; Liao, X. Charlene

2016-01-01

ABSTRACT Cytomegalovirus (CMV) infection is a significant complication after kidney transplantation. We examined the ability of RG7667, a combination of two monoclonal antibodies, to prevent CMV infection in high-risk kidney transplant recipients in a randomized, double-blind, placebo-controlled trial. CMV-seronegative recipients of a kidney transplant from a CMV-seropositive donor (D+R−) were randomized to receive RG7667 (n = 60) or placebo (n = 60) at the time of transplant and 1, 4, and 8 weeks posttransplant. Patients were monitored for CMV viremia every 1 to 2 weeks posttransplant for 24 weeks. Patients who had seroconverted (D+R+) or withdrawn before dosing were excluded from the analysis (n = 4). CMV viremia occurred in 27 of 59 (45.8%) patients receiving RG7667 and 35 of 57 (61.4%) patients receiving placebo (stratum-adjusted difference, 15.3%; P = 0.100) within 12 weeks posttransplant and in 30 of 59 (50.8%) patients receiving RG7667 and 40 of 57 (70.2%) patients receiving placebo (stratum-adjusted difference, 19.3%; P = 0.040) within 24 weeks posttransplant. Median time to CMV viremia was 139 days in patients receiving RG7667 compared to 46 days in patients receiving placebo (hazard ratio, 0.53; P = 0.009). CMV disease was less common in the RG7667 than placebo group (3.4% versus 15.8%; P = 0.030). Adverse events were generally balanced between treatment groups. In high-risk kidney transplant recipients, RG7667 was well tolerated, numerically reduced the incidence of CMV infection within 12 and 24 weeks posttransplant, delayed time to CMV viremia, and was associated with less CMV disease than the placebo. (This study has been registered at ClinicalTrials.gov under registration no. NCT01753167.) PMID:27872061

Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats.

PubMed

Xu, Yuxia; Zhang, Peng; Wang, Chu; Shan, Ye; Wang, Dandan; Qian, Fenglei; Sun, Mengwei; Zhu, Cuiqing

2013-10-28

Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, little is known about the cellular and molecular mechanisms of Rg3 on anti-fatigue and the effect of Rg3 on dopaminergic system has not been reported yet. The major aim of this study is to investigate the effect of Rg3 on TH expression and the related biochemical parameters, such as PKAα, ERK1/2, Akt and α-synuclein in brain of fatigue rats. Weight-loaded forced swimming was performed to establish an animal model of fatigue. Rg3 (10mg/kg, 50mg/kg and 100mg/kg) was intragastrically administrated before swimming. The effect of Rg3 on the expression and phosphorylation of TH and TH-related proteins in fatigue rats or in SH-SY5Y cells was assessed with western blotting. HPLC was used to examine the level of DA and DOPAC in the fatigue rats tissues. TH and phosphorylated TH were decreased in different brain regions of which ventral midbrain were less affected in weight-loaded forced swimming rats. Pretreatment with Rg3 significantly suppressed fatigue-induced decrease expression of TH and TH phosphorylation. Also treatment with Rg3 reversed the decrease expression of PKAα as well as the phosphorylation of ERK1/2 and Akt which were induced by weight-loaded forced swimming. Moreover, weight-loaded swimming could induce the increase expression of α-synuclein in hippocampus and midbrain, while suppressed α-synuclein expression in striatum and prefrontal cortex. Furthermore, Rg3 could induce the increase of TH expression and phosphorylation which was accompanied with elevated expression and phosphorylation of related kinase proteins in vitro, while the inhibitors of kinase proteins could suppress these effects of Rg3. In addition, HPLC results showed that Rg3 could reverse the weight-loaded swimming-induced increase of DOPAC/DA ratio. Our data suggest that fatigue can induce the decrease of DA which might partially

Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding

PubMed Central

Ozdilek, Bagdeser A.; Thompson, Valery F.; Ahmed, Nasiha S.; White, Connor I.

2017-01-01

Abstract RGG/RG domains are the second most common RNA binding domain in the human genome, yet their RNA-binding properties remain poorly understood. Here, we report a detailed analysis of the RNA binding characteristics of intrinsically disordered RGG/RG domains from Fused in Sarcoma (FUS), FMRP and hnRNPU. For FUS, previous studies defined RNA binding as mediated by its well-folded domains; however, we show that RGG/RG domains are the primary mediators of binding. RGG/RG domains coupled to adjacent folded domains can achieve affinities approaching that of full-length FUS. Analysis of RGG/RG domains from FUS, FMRP and hnRNPU against a spectrum of contrasting RNAs reveals that each display degenerate binding specificity, while still displaying different degrees of preference for RNA. PMID:28575444

640 X 486 Long-Wavelength Two-Color GaAs/AlGaAs Quantum Well Infrared Photodetector (QWIP) Focal Plane Array Camera

NASA Astrophysics Data System (ADS)

Gunapala, S. D.; Bandara, S. V.; Singh, A.; Liu, J. K.; Rafol, S. B.

2000-01-01

We have designed and fabricated an optimized long-wavelength/very-long-wavelength two-color quantum well infrared photodetector (QWIP) device structure. The device structure was grown on a 3-in semi-insulating GaAs substrate by molecular beam epitaxy (MBE). The wafer was processed into several 640 x 486 format monolithically integrated 8-9 and 14-15 micrometers two-color (or dual wavelength) QWIP focal plane arrays (FPA's). These FPA's were then hybridized to 640 x 486 silicon CMOS readout multiplexers. A thinned (i.e., substrate removed) FPA hybrid was integrated into liquid helium cooled dewar for electrical and optical characterization and to demonstrate simultaneous two-color imagery. The 8-9 micrometers detectors in the FPA have shown background limited performance (BLIP) at 70 K operating temperature for 300 K background with f/2 cold stop. The 14-15 micrometers detectors of the SPA reach BLIP at 40 K operating temperature under the same background conditions. In this paper we discuss the performance of this long-wavelength dualband QWIP SPA in terms of quantum efficiency, detectivity, noise equivalent temperature difference (NE DELTA T), uniformity, and operability.

Ginsenoside Rg1 nanoparticle penetrating the blood-brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction.

PubMed

Shen, Junyi; Zhao, Zhiming; Shang, Wei; Liu, Chunli; Zhang, Beibei; Zhao, Lingjie; Cai, Hui

2017-01-01

Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1) has a wide variety of therapeutic values for central nervous system (CNS) diseases for the neuron protective effects. However, the blood-brain barrier (BBB) restricts Rg1 in reaching the CNS. In this study, we investigated the therapeutic effects of Rg1 nanoparticle (PHRO, fabricated with γ-PGA, L-PAE (H), Rg1, and OX26 antibody), targeting transferrin receptor, on the diabetes rats complicated with diabetic cerebral infarction in vitro and in vivo. Dynamic light scattering analysis shows the average particle size of PHRO was 79±18 nm and the polydispersity index =0.18. The transmission electron microscope images showed that all NPs were spherical in shape with diameters of 89±23 nm. PHRO released Rg1 with sustained release manner and could promote the migration of cerebrovascular endothelial cells and tube formation and even penetrated the BBB in vitro. PHRO could penetrate the BBB with high concentration in brain tissue to reduce the cerebral infarction volume and promote neuronal recovery in vivo. PHRO was promising to be a clinical treatment of diabetes mellitus with cerebral infarction.

Ginsenoside Rg1 nanoparticle penetrating the blood–brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction

PubMed Central

Shen, Junyi; Zhao, Zhiming; Shang, Wei; Liu, Chunli; Zhang, Beibei; Zhao, Lingjie; Cai, Hui

2017-01-01

Diabetic cerebral infarction is with poorer prognosis and high rates of mortality. Ginsenoside Rg1 (Rg1) has a wide variety of therapeutic values for central nervous system (CNS) diseases for the neuron protective effects. However, the blood–brain barrier (BBB) restricts Rg1 in reaching the CNS. In this study, we investigated the therapeutic effects of Rg1 nanoparticle (PHRO, fabricated with γ-PGA, L-PAE (H), Rg1, and OX26 antibody), targeting transferrin receptor, on the diabetes rats complicated with diabetic cerebral infarction in vitro and in vivo. Dynamic light scattering analysis shows the average particle size of PHRO was 79±18 nm and the polydispersity index =0.18. The transmission electron microscope images showed that all NPs were spherical in shape with diameters of 89±23 nm. PHRO released Rg1 with sustained release manner and could promote the migration of cerebrovascular endothelial cells and tube formation and even penetrated the BBB in vitro. PHRO could penetrate the BBB with high concentration in brain tissue to reduce the cerebral infarction volume and promote neuronal recovery in vivo. PHRO was promising to be a clinical treatment of diabetes mellitus with cerebral infarction. PMID:28919749

Electrochemical generation of sulfur vacancies in the basal plane of MoS2 for hydrogen evolution

PubMed Central

Tsai, Charlie; Li, Hong; Park, Sangwook; Park, Joonsuk; Han, Hyun Soo; Nørskov, Jens K.; Zheng, Xiaolin; Abild-Pedersen, Frank

2017-01-01

Recently, sulfur (S)-vacancies created on the basal plane of 2H-molybdenum disulfide (MoS2) using argon plasma exposure exhibited higher intrinsic activity for the electrochemical hydrogen evolution reaction than the edge sites and metallic 1T-phase of MoS2 catalysts. However, a more industrially viable alternative to the argon plasma desulfurization process is needed. In this work, we introduce a scalable route towards generating S-vacancies on the MoS2 basal plane using electrochemical desulfurization. Even though sulfur atoms on the basal plane are known to be stable and inert, we find that they can be electrochemically reduced under accessible applied potentials. This can be done on various 2H-MoS2 nanostructures. By changing the applied desulfurization potential, the extent of desulfurization and the resulting activity can be varied. The resulting active sites are stable under extended desulfurization durations and show consistent HER activity. PMID:28429782

Electrochemical generation of sulfur vacancies in the basal plane of MoS2 for hydrogen evolution

DOE PAGES

Tsai, Charlie; Li, Hong; Park, Sangwook; ...

2017-04-21

Recently, sulfur (S)-vacancies created on the basal plane of 2H-molybdenum disulfide (MoS 2) using argon plasma exposure exhibited higher intrinsic activity for the electrochemical hydrogen evolution reaction than the edge sites and metallic 1T-phase of MoS 2 catalysts. But, a more industrially viable alternative to the argon plasma desulfurization process is needed. In this work, we introduce a scalable route towards generating S-vacancies on the MoS 2 basal plane using electrochemical desulfurization. We found that they can be electrochemically reduced under accessible applied potentials, even though sulfur atoms on the basal plane are known to be stable and inert. Thismore » can be done on various 2H-MoS 2 nanostructures. Furthermore, by changing the applied desulfurization potential, the extent of desulfurization and the resulting activity can be varied. The resulting active sites are stable under extended desulfurization durations and show consistent HER activity.« less

Characterization of X-ray Lobster Optics with a Hybrid CMOS sensor

NASA Astrophysics Data System (ADS)

Chattopadhyay, Tanmoy; Falcone, Abraham; Burrows, David N.; Bray, Evan; McQuaide, Maria; Kern, Matthew; Wages, Mitchell; Hull, Samuel; Inneman, Adolf; Hudec, Rene; Stehlikova, Veronika

2018-01-01