Hyaluronic Acid Hydrogels for Biomedical Applications
Burdick, Jason A.; Prestwich, Glenn D.
2013-01-01
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many physical forms -- viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non-woven meshes, macroporous and fibrillar sponges, flexible sheets, and nanoparticulate fluids -- for use in a range of preclinical and clinical settings. Many of these forms are derived from the chemical crosslinking of pendant reactive groups by addition/condensation chemistry or by radical polymerization. Clinical products for cell therapy and regenerative medicine require crosslinking chemistry that is compatible with the encapsulation of cells and injection into tissues. Moreover, an injectable clinical biomaterial must meet marketing, regulatory, and financial constraints to provide affordable products that can be approved, deployed to the clinic, and used by physicians. Many HA-derived hydrogels meet these criteria, and can deliver cells and therapeutic agents for tissue repair and regeneration. This progress report covers both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications. PMID:21394792
Alalwiat, Ahlam; Tang, Wen; Gerişlioğlu, Selim; Becker, Matthew L; Wesdemiotis, Chrys
2017-01-17
The bioconjugate BMP2-(PEO-HA) 2 , composed of a dendron with two monodisperse poly(ethylene oxide) (PEO) branches terminated by a hydroxyapatite binding peptide (HA), and a focal point substituted with a bone growth stimulating peptide (BMP2), has been comprehensively characterized by mass spectrometry (MS) methods, encompassing matrix-assisted laser desorption ionization (MALDI), electrospray ionization (ESI), tandem mass spectrometry (MS 2 ), and ion mobility mass spectrometry (IM-MS). MS 2 experiments using different ion activation techniques validated the sequences of the synthetic, bioactive peptides HA and BMP2, which contained highly basic amino acid residues either at the N-terminus (BMP2) or C-terminus (HA). Application of MALDI-MS, ESI-MS, and IM-MS to the polymer-peptide biomaterial confirmed its composition. Collision cross-section measurements and molecular modeling indicated that BMP2-(PEO-HA) 2 exists in several folded and extended conformations, depending on the degree of protonation. Protonation of all basic sites of the hybrid material nearly doubles its conformational space and accessible surface area.
Nagaoka, Aya; Yoshida, Hiroyuki; Nakamura, Sachiko; Morikawa, Tomohiko; Kawabata, Keigo; Kobayashi, Masaki; Sakai, Shingo; Takahashi, Yoshito; Okada, Yasunori; Inoue, Shintaro
2015-12-25
Regulation of hyaluronan (HA) synthesis and degradation is essential to maintenance of extracellular matrix homeostasis. We recently reported that HYBID (HYaluronan-Binding protein Involved in hyaluronan Depolymerization), also called KIAA1199, plays a key role in HA depolymerization in skin and arthritic synovial fibroblasts. However, regulation of HA metabolism mediated by HYBID and HA synthases (HASs) under stimulation with growth factors remains obscure. Here we report that TGF-β1, basic FGF, EGF, and PDGF-BB commonly enhance total amount of HA in skin fibroblasts through up-regulation of HAS expression, but molecular size of newly produced HA is dependent on HYBID expression levels. Stimulation of HAS1/2 expression and suppression of HYBID expression by TGF-β1 were abrogated by blockade of the MAPK and/or Smad signaling and the PI3K-Akt signaling, respectively. In normal human skin, expression of the TGF-β1 receptors correlated positively with HAS2 expression and inversely with HYBID expression. On the other hand, TGF-β1 up-regulated HAS1/2 expression but exerted only a slight suppressive effect on HYBID expression in synovial fibroblasts from the patients with osteoarthritis or rheumatoid arthritis, resulting in the production of lower molecular weight HA compared with normal skin and synovial fibroblasts. These data demonstrate that although TGF-β1, basic FGF, EGF, and PDGF-BB enhance HA production in skin fibroblasts, TGF-β1 most efficiently contributes to production of high molecular weight HA by HAS up-regulation and HYBID down-regulation and suggests that inefficient down-regulation of HYBID by TGF-β1 in arthritic synovial fibroblasts may be linked to accumulation of depolymerized HA in synovial fluids in arthritis patients. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Zhu, Xiaojing; He, Jiangtao; Su, Sihui; Zhang, Xiaoliang; Wang, Fei
2016-05-01
To explore the interactions between soil organic matter and minerals, humic acid (HA, as organic matter), kaolin (as a mineral component) and Ca(2+) (as metal ions) were used to prepare HA-kaolin and Ca-HA-kaolin complexes. These complexes were used in trichloroethylene (TCE) sorption experiments and various characterizations. Interactions between HA and kaolin during the formation of their complexes were confirmed by the obvious differences between the Qe (experimental sorbed TCE) and Qe_p (predicted sorbed TCE) values of all detected samples. The partition coefficient kd obtained for the different samples indicated that both the organic content (fom) and Ca(2+) could significantly impact the interactions. Based on experimental results and various characterizations, a concept model was developed. In the absence of Ca(2+), HA molecules first patched onto charged sites of kaolin surfaces, filling the pores. Subsequently, as the HA content increased and the first HA layer reached saturation, an outer layer of HA began to form, compressing the inner HA layer. As HA loading continued, the second layer reached saturation, such that an outer-third layer began to form, compressing the inner layers. In the presence of Ca(2+), which not only can promote kaolin self-aggregation but can also boost HA attachment to kaolin, HA molecules were first surrounded by kaolin. Subsequently, first and second layers formed (with inner layer compression) via the same process as described above in the absence of Ca(2+), except that the second layer continued to load rather than reach saturation, within the investigated conditions, because of enhanced HA aggregation caused by Ca(2+). Copyright © 2016 Elsevier Ltd. All rights reserved.
Vink, Sylvia; van Tartwijk, Jan; Verloop, Nico; Gosselink, Manon; Driessen, Erik; Bolk, Jan
2016-08-01
To determine the content of integrated curricula, clinical concepts and the underlying basic science concepts need to be made explicit. Preconstructed concept maps are recommended for this purpose. They are mainly constructed by experts. However, concept maps constructed by residents are hypothesized to be less complex, to reveal more tacit basic science concepts and these basic science concepts are expected to be used for the organization of the maps. These hypotheses are derived from studies about knowledge development of individuals. However, integrated curricula require a high degree of cooperation between clinicians and basic scientists. This study examined whether there are consistent variations regarding the articulation of integration when groups of experienced clinicians and basic scientists and groups of residents and basic scientists-in-training construct concept maps. Seven groups of three clinicians and basic scientists on experienced level and seven such groups on resident level constructed concept maps illuminating clinical problems. They were guided by instructions that focused them on articulation of integration. The concept maps were analysed by features that described integration. Descriptive statistics showed consistent variations between the two expertise levels. The concept maps of the resident groups exceeded those of the experienced groups in articulated integration. First, they used significantly more links between clinical and basic science concepts. Second, these links connected basic science concepts with a greater variety of clinical concepts than the experienced groups. Third, although residents did not use significantly more basic science concepts, they used them significantly more frequent to organize the clinical concepts. The conclusion was drawn that not all hypotheses could be confirmed and that the resident concept maps were more elaborate than expected. This article discusses the implications for the role that residents and basic scientists-in-training might play in the construction of preconstructed concept maps and the development of integrated curricula.
Gloria, A.; Russo, T.; D'Amora, U.; Zeppetelli, S.; D'Alessandro, T.; Sandri, M.; Bañobre-López, M.; Piñeiro-Redondo, Y.; Uhlarz, M.; Tampieri, A.; Rivas, J.; Herrmannsdörfer, T.; Dediu, V. A.; Ambrosio, L.; De Santis, R.
2013-01-01
In biomedicine, magnetic nanoparticles provide some attractive possibilities because they possess peculiar physical properties that permit their use in a wide range of applications. The concept of magnetic guidance basically spans from drug delivery and hyperthermia treatment of tumours, to tissue engineering, such as magneto-mechanical stimulation/activation of cell constructs and mechanosensitive ion channels, magnetic cell-seeding procedures, and controlled cell proliferation and differentiation. Accordingly, the aim of this study was to develop fully biodegradable and magnetic nanocomposite substrates for bone tissue engineering by embedding iron-doped hydroxyapatite (FeHA) nanoparticles in a poly(ε-caprolactone) (PCL) matrix. X-ray diffraction analyses enabled the demonstration that the phase composition and crystallinity of the magnetic FeHA were not affected by the process used to develop the nanocomposite substrates. The mechanical characterization performed through small punch tests has evidenced that inclusion of 10 per cent by weight of FeHA would represent an effective reinforcement. The inclusion of nanoparticles also improves the hydrophilicity of the substrates as evidenced by the lower values of water contact angle in comparison with those of neat PCL. The results from magnetic measurements confirmed the superparamagnetic character of the nanocomposite substrates, indicated by a very low coercive field, a saturation magnetization strictly proportional to the FeHA content and a strong history dependence in temperature sweeps. Regarding the biological performances, confocal laser scanning microscopy and AlamarBlue assay have provided qualitative and quantitative information on human mesenchymal stem cell adhesion and viability/proliferation, respectively, whereas the obtained ALP/DNA values have shown the ability of the nanocomposite substrates to support osteogenic differentiation. PMID:23303218
A brain-based account of “basic-level” concepts
Bauer, Andrew James; Just, Marcel Adam
2017-01-01
This study provides a brain-based account of how object concepts at an intermediate (basic) level of specificity are represented, offering an enriched view of what it means for a concept to be a basic-level concept, a research topic pioneered by Rosch and others (Rosch et al., 1976). Applying machine learning techniques to fMRI data, it was possible to determine the semantic content encoded in the neural representations of object concepts at basic and subordinate levels of abstraction. The representation of basic-level concepts (e.g. bird) was spatially broad, encompassing sensorimotor brain areas that encode concrete object properties, and also language and heteromodal integrative areas that encode abstract semantic content. The representation of subordinate-level concepts (robin) was less widely distributed, concentrated in perceptual areas that underlie concrete content. Furthermore, basic-level concepts were representative of their subordinates in that they were neurally similar to their typical but not atypical subordinates (bird was neurally similar to robin but not woodpecker). The findings provide a brain-based account of the advantages that basic-level concepts enjoy in everyday life over subordinate-level concepts: the basic level is a broad topographical representation that encompasses both concrete and abstract semantic content, reflecting the multifaceted yet intuitive meaning of basic-level concepts. PMID:28826947
A brain-based account of "basic-level" concepts.
Bauer, Andrew James; Just, Marcel Adam
2017-11-01
This study provides a brain-based account of how object concepts at an intermediate (basic) level of specificity are represented, offering an enriched view of what it means for a concept to be a basic-level concept, a research topic pioneered by Rosch and others (Rosch et al., 1976). Applying machine learning techniques to fMRI data, it was possible to determine the semantic content encoded in the neural representations of object concepts at basic and subordinate levels of abstraction. The representation of basic-level concepts (e.g. bird) was spatially broad, encompassing sensorimotor brain areas that encode concrete object properties, and also language and heteromodal integrative areas that encode abstract semantic content. The representation of subordinate-level concepts (robin) was less widely distributed, concentrated in perceptual areas that underlie concrete content. Furthermore, basic-level concepts were representative of their subordinates in that they were neurally similar to their typical but not atypical subordinates (bird was neurally similar to robin but not woodpecker). The findings provide a brain-based account of the advantages that basic-level concepts enjoy in everyday life over subordinate-level concepts: the basic level is a broad topographical representation that encompasses both concrete and abstract semantic content, reflecting the multifaceted yet intuitive meaning of basic-level concepts. Copyright © 2017 Elsevier Inc. All rights reserved.
Hybrid Airships: Intratheater Operations Cost-Benefit Analysis
2011-06-01
airships (HA) in an intratheater humanitarian assistance scenario. A linear programming model was used to study various mixes of hybrid airships...i.e. 200 tons) must be moved as quickly as possible (or during sealift transit), then HA operating costs of $3,000 per hour or less also make them a ...for Future Research ................................................................................ 52 Appendix A : Examples of HA Concepts/Prototypes
Preparation and characterization of bio-composite PEEK/nHA
NASA Astrophysics Data System (ADS)
Jin, Y. S.; Bian, C. C.; Zhang, Z. Q.; Zhao, Y.; Yang, L.
2017-01-01
PEEK/nHA composite material, with excellent mechanical property as polyetheretherketone (PEEK) and biological activity as hydroxyapatite (HA), has attracted wide attention of medical experts and materials science experts. The addition of hydroxyapatite was the decisive factor for biological activity in PEEK/nHA composite. In this paper, acicular nanohydroxyapatite was prepared by chemical precipitation method with Ca(NO3)2, (NH4)2HPO4 as raw material; PEEK/nHA composite was prepared by solution blending and vacuum sintering method. The composite was characterized with FT-IR, XRD, DSC, TG and mechanical property test. Results showed that the composite has good thermal stability and compressive property when the mass ratio of PEEK to nHA is 10:3; and high nHA content can improve the biological activity of the composite, which can meet the basic requirements for bone tissue engineering scaffold.
Synthesis, structural properties and thermal stability of Mn-doped hydroxyapatite
NASA Astrophysics Data System (ADS)
Paluszkiewicz, Czesława; Ślósarczyk, Anna; Pijocha, Dawid; Sitarz, Maciej; Bućko, Mirosław; Zima, Aneta; Chróścicka, Anna; Lewandowska-Szumieł, Małgorzata
2010-07-01
Hydroxyapatite (HA) - Ca 10(PO 4) 6(OH) 2 is a basic inorganic model component of hard biological tissues, such as bones and teeth. The significant property of HA is its ability to exchange Ca 2+ ions, which influences crystallinity, physico-chemical and biological properties of modified hydroxyapatite materials. In this work, FTIR, Raman spectroscopy, XRD, SEM and EDS techniques were used to determine thermal stability, chemical and phase composition of Mn containing hydroxyapatite (MnHA). Described methods confirmed thermal decomposition and phase transformation of MnHA to αTCP, βTCP and formation of Mn 3O 4 depending on sintering temperature and manganese content. In vitro biological evaluation of Mn-modified HA ceramics was also performed using human osteoblast cells.
The availability and accessibility of basic concept vocabulary in AAC software: a preliminary study.
McCarthy, Jillian H; Schwarz, Ilsa; Ashworth, Morgan
2017-09-01
Core vocabulary lists obtained through the analyses of children's utterances include a variety of basic concept words. Supporting young children who use augmentative and alternative communication (AAC) to develop their understanding and use of basic concepts is an area of practice that has important ramifications for successful communication in a classroom environment. This study examined the availability of basic concept words across eight frequently used, commercially available AAC language systems, iPad© applications, and symbol libraries used to create communication boards. The accessibility of basic concept words was subsequently examined using two AAC language page sets and two iPad applications. Results reveal that the availability of basic concept words represented within the different AAC language programs, iPad applications, and symbol libraries varied but was limited across programs. However, there is no significant difference in the accessibility of basic concept words across the language program page sets or iPad applications, generally because all of them require sophisticated motor and cognitive plans for access. These results suggest that educators who teach or program vocabulary in AAC systems need to be mindful of the importance of basic concept words in classroom settings and, when possible, enhance the availability and accessibility of these words to users of AAC.
Drawing on Student Knowledge of Neuroanatomy and Neurophysiology
ERIC Educational Resources Information Center
Slominski, Tara N.; Momsen, Jennifer L.; Montplaisir, Lisa M.
2017-01-01
Drawings are an underutilized assessment format in Human Anatomy and Physiology (HA&P), despite their potential to reveal student content understanding and alternative conceptions. This study used student-generated drawings to explore student knowledge in a HA&P course. The drawing tasks in this study focused on chemical synapses between…
Cushnie, Emily K; Khan, Yusuf M; Laurencin, Cato T
2010-08-01
A tissue-engineered bone graft should imitate the ideal autograft in both form and function. However, biomaterials that have appropriate chemical and mechanical properties for grafting applications often lack biological components that may enhance regeneration. The concept of adding proteins such as growth factors to scaffolds has therefore emerged as a possible solution to improve overall graft design. In this study, we investigated this concept by loading porous hydroxyapatite-poly(lactide-co-glycolide) (HA-PLAGA) scaffolds with a model protein, cytochrome c, and then studying its release in a phosphate-buffered saline solution. The HA-PLAGA scaffold has previously been shown to be bioactive, osteoconductive, and to have appropriate physical properties for tissue engineering applications. The loading experiments demonstrated that the HA-PLAGA scaffold could also function effectively as a substrate for protein adsorption and release. Scaffold protein adsorptive loading (as opposed to physical entrapment within the matrix) was directly related to levels of scaffold HA-content. The HA phase of the scaffold facilitated protein retention in the matrix following incubation in aqueous buffer for periods up to 8 weeks. Greater levels of protein retention time may improve the protein's effective activity by increasing the probability for protein-cell interactions. The ability to control protein loading and delivery simply via composition of the HA-PLAGA scaffold offers the potential of forming robust functionalized bone grafts. (c) 2010 Wiley Periodicals, Inc.
ERIC Educational Resources Information Center
Gibbs, Marilyn J.
1988-01-01
Teaching four basic badminton concepts along with the usual basic skill shots allows players to develop game strategy awareness as well as mechanical skills. These four basic concepts are: (1) ready position, (2) flight trajectory, (3) early shuttle contact, and (4) camouflage. (IAH)
Hydroxyapatite-binding peptides for bone growth and inhibition
Bertozzi, Carolyn R [Berkeley, CA; Song, Jie [Shrewsbury, MA; Lee, Seung-Wuk [Walnut Creek, CA
2011-09-20
Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.
ten Berge, Hein F M; van der Meer, Hugo G; Steenhuizen, Johan W; Goedhart, Paul W; Knops, Pol; Verhagen, Jan
2012-01-01
Mineral carbonation of basic silicate minerals regulates atmospheric CO(2) on geological time scales by locking up carbon. Mining and spreading onto the earth's surface of fast-weathering silicates, such as olivine, has been proposed to speed up this natural CO(2) sequestration ('enhanced weathering'). While agriculture may offer an existing infrastructure, weathering rate and impacts on soil and plant are largely unknown. Our objectives were to assess weathering of olivine in soil, and its effects on plant growth and nutrient uptake. In a pot experiment with perennial ryegrass (Lolium perenne L.), weathering during 32 weeks was inferred from bioavailability of magnesium (Mg) in soil and plant. Olivine doses were equivalent to 1630 (OLIV1), 8150, 40700 and 204000 (OLIV4) kg ha(-1). Alternatively, the soluble Mg salt kieserite was applied for reference. Olivine increased plant growth (+15.6%) and plant K concentration (+16.5%) in OLIV4. At all doses, olivine increased bioavailability of Mg and Ni in soil, as well as uptake of Mg, Si and Ni in plants. Olivine suppressed Ca uptake. Weathering estimated from a Mg balance was equivalent to 240 kg ha(-1) (14.8% of dose, OLIV1) to 2240 kg ha(-1) (1.1%, OLIV4). This corresponds to gross CO(2) sequestration of 290 to 2690 kg ha(-1) (29 10(3) to 269 10(3) kg km(-2).) Alternatively, weathering estimated from similarity with kieserite treatments ranged from 13% to 58% for OLIV1. The Olsen model for olivine carbonation predicted 4.0% to 9.0% weathering for our case, independent of olivine dose. Our % values observed at high doses were smaller than this, suggesting negative feedbacks in soil. Yet, weathering appears fast enough to support the 'enhanced weathering' concept. In agriculture, olivine doses must remain within limits to avoid imbalances in plant nutrition, notably at low Ca availability; and to avoid Ni accumulation in soil and crop.
NASA Technical Reports Server (NTRS)
Katow, S. M.
1979-01-01
The computer analysis of the 34-m HA-DEC antenna by the IDEAS program provided the rms distortions of the surface panels support points for full gravity loadings in the three directions of the basic coordinate system of the computer model. The rms distortions for the gravity vector not in line with any of the three basic directions were solved and contour plotted starting from three surface panels setting declination angle. By inspections of the plots, it was concluded that the setting or rigging angle of -15 degrees declination minimized the rms distortions for sky coverage of plus or minus 22 declination angles to 10 degrees of ground mask.
ERIC Educational Resources Information Center
Acar, Tulin; Voltan-Acar, Nilufer
2013-01-01
The aim of this study was to evaluate the basic concepts of multigenerational Family Therapy and to evaluate the scenes of the film ''My Father and My Son'' according to these concepts. For these purposes firstly basic concepts of Multigenerational Family Therapy such as differentiation of self, triangles/triangulation, nuclear family emotional…
Sun, Jin P; Dai, Jianhong; Song, Yan; Wang, You; Yang, Rui
2014-12-10
A basic understanding of the affinity between the hydroxyapatite (HA) and α-Ti surfaces is obtained through electronic structure calculations by first-principles method. The surface energies of HA(0001), HA (011̅0), HA (101̅1), and Ti(0001) surfaces have been calculated. The HA(0001) presents the most thermodynamically stable of HA. The HA/Ti interfaces were constructed by two kinds of interface models, the single interface (denoted as SI) and the double-interface (denoted as DI). Two methods, the full relaxation and the UBER, were applied to determine the interfacial separation and the atomic arrangement in the interfacial zone. The works of adhesion of interfaces with various stoichiometric HA surfaces were evaluated. For the HA(0001)/Ti(0001) interfaces, the work of adhesion is strongly dependent on the chemical environment of the HA surface. The values are -2.33, -1.52, and -0.80 J/m(2) for the none-, single-, and double-Ca terminated HA/Ti interfaces, respectively. The influence of atomic relaxation on the work of adhesion and interface separation is discussed. Full relaxation results include -1.99 J/m(2) work of adhesion and 0.220 nm separation between HA and Ti for the DI of 1-Ca-HA/Ti interface, while they are -1.14 J/m(2) and 0.235 nm by partial relaxation. Analysis of electronic structure reveals that charge transfer between HA and Ti slabs occurs during the formation of the HA/Ti interface. The transfer generates the Ti-O or Ti-Ca bonds across the interface and drives the HA/Ti interface system to metallic characteristic. The energetically favorable interfaces are formed when the outmost layer of HA comprises more O atoms at the interface.
Inbal, Amir; Lemelman, Benjamin T; Millet, Eran; Greensmith, Andrew
2017-10-16
Auricular reconstruction is one of the most challenging procedures in plastic surgery. An adequate skin envelope is essential for cartilage framework coverage, yet few good options exist without additional surgery. We propose a novel method for minimally invasive tissue expansion, using hyaluronic acid (HA) filler to allow for single-stage ear reconstruction. To introduce the novel concept of HA filler for tissue expansion in ear reconstruction, and as an alternative to traditional expansion techniques. Macrolane is a large particle HA gel developed for large volume restoration. Expansion of the non-hair-bearing mastoid skin was performed in our clinic weekly or every other week. Final expansion was completed one week prior to reconstructive surgery. Tissue from one patient's expanded pocket was sent for histological analysis. Ten patients underwent single-stage auricular reconstruction with preoperative expansion. Injection sessions ranged from 7 to 13 (mean, 9.7). Mean injected volume per session was 2.03 mL per patient, for an average total of 19.8 mL (range, 14.5-30 mL). There were no major complications. One minor complication required removal of exposed wire from the antihelix in the office. Hematoxylin and eosin stain revealed similar histology to that seen with traditional expanders. This novel expansion technique using serial HA injections allowed for optimized skin coverage in single-stage ear reconstruction. The concept of tissue expansion using HA filler is a new frontier for research that may be applicable to other arenas of reconstruction. 4. © 2017 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com
Jin, Qiang; Feng, Lei; Zhang, Shui-Jun; Wang, Dan-Dan; Wang, Fang-Jun; Zhang, Yi; Cui, Jing-Nan; Guo, Wen-Zhi; Ge, Guang-Bo; Yang, Ling
2017-09-19
In this study, a novel fluorescent detection system for biological sensing of human albumin (HA) was developed on the basis of the pseudoesterase activity and substrate preference of HA. The designed near-infrared (NIR) fluorescent probe (DDAP) could be effectively hydrolyzed by HA, accompanied by significant changes in both color and fluorescence spectrum. The sensing mechanism was fully investigated by fluorescence spectroscopy, NMR, and mass spectra. DDAP exhibited excellent selectivity and sensitivity toward HA over a variety of human plasma proteins, hydrolases, and abundant biomolecules found in human body. The probe has been successfully applied to measure native HA in diluted plasma samples and the secreted HA in the hepatocyte culture supernatant. DDAP has also been used for fluorescence imaging of HA reabsorption in living renal cells, and the results show that the probe exhibits good cell permeability, low cytotoxicity and high imaging resolution. Furthermore, DDAP has been successfully used for real-time tracking the uptaking and degradation of albumin in ex vivo mouse kidney models for the first time. All these results clearly demonstrated that DDAP-based assay held great promise for real-time sensing and tracking HA in complex biological systems, which would be very useful for basic researches and clinical diagnosis of HA-associated diseases.
Šafránková, Barbora; Hermannová, Martina; Nešporová, Kristina; Velebný, Vladimír; Kubala, Lukáš
2018-02-01
Hyaluronan (HA) effects on immune response are suggested to be dependent on HA molecular weight (MW), as low MW HA should activate immune cells in contrast to high MW HA. However, some current studies do not support this conception and emphasize the importance of the form of preparation of HA, particularly with respect to its purity and origin. We compared the activation of mouse immune cells by HA samples (100kDa, 500kDa, and 997kDa) prepared from HA originating from rooster comb, and HA samples (71kDa, 500kDa, and 1000kDa) prepared from pharmacological grade HA originating from Streptococcus equi. Interestingly, in contrast to established theory, only middle and high MW HA originating from rooster comb induced the production of tumor necrosis factor-α by macrophages and in whole blood. Further, all tested preparations of HA failed to induce the expression of inducible nitric oxide synthase, the production of nitric oxide, or the expression of cyclooxygenase 2 in macrophages and splenocytes. Importantly, all HA samples originating from rooster comb were found to be contaminated by endotoxin (up to 1.23EU/ml). Hence, low MW HA did not reveal itself to have significantly higher immunostimulatory activity compared to HA of higher MW. Copyright © 2017 Elsevier B.V. All rights reserved.
Campaign Sii Ha Sin: Shaping the Future of Tribal Colleges and Universities
ERIC Educational Resources Information Center
American Indian College Fund, 2004
2004-01-01
The impact of the American Indian College Fund's Campaign Sii Ha Sin has been immediate and profound. The capital campaign, appropriately named for the Navajo concept of hope, has helped establish the tribal colleges as a positive and central force in American Indian higher education, the communities served by the tribal colleges and ultimately,…
Back to the Future: Does History Support the Expeditionary Air Force Concept?
2000-04-01
Operations Forces 550, “Agile Combat Support,” Mr. Ron Orr, USAF/IL, 2 Feb 00. 4 Davis, pg. 11. 5 Toulmin , H.A., Jr., Air Service, American...John A., “The Expeditionary Air Force Takes Shape,” Air Force Magazine, Vol. 80, No. 6, June 1997. Toulmin , H.A., Jr., Air Service, American
ERIC Educational Resources Information Center
Balat, Gülden Uyanik
2014-01-01
Most basic concepts are acquired during preschool period. There are studies indicating that the basic concept knowledge of children is related to language development, cognitive development, academic achievement and intelligence. The relationship between learning behaviors (sometime called learning or cognitive styles) and a child academic success…
Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants.
Schnettler, Reinhard; Alt, Volker; Dingeldein, Elvira; Pfefferle, Hans-Joachim; Kilian, Olaf; Meyer, Christof; Heiss, Christian; Wenisch, Sabine
2003-11-01
This experimental study was performed to evaluate angiogenesis, bone formation, and bone ingrowth in response to osteoinductive implants of bovine-derived hydroxyapatite (HA) ceramics either uncoated or coated with basic fibroblast growth factor (bFGF) in miniature pigs. A cylindrical bone defect was created in both femur condyles of 24 miniature pigs using a saline coated trephine. Sixteen of the 48 defects were filled with HA cylinders coated with 50 microg rhbFG, uncoated HA cylinders, and with autogenous transplants, respectively. Fluorochrome labelled histological analysis, histomorphometry, and scanning electron microscopy were performed to study angiogenesis, bone formation and bone ingrowth. Complete bone ingrowth into bFGF-coated HA implants and autografts was seen after 34 days compared to 80 days in the uncoated HA group. Active ring-shaped areas of fluorochrome labelled bone deposition with dynamic bone remodelling were found in all cylinders. New vessels could be found in all cylinders. Histomorphometric analysis showed no difference in bone ingrowth over time between autogenous transplants and bFGF-coated HA implants. The current experimental study revealed comparable results of bFGF-coated HA implants and autogenous grafts regarding angiogenesis, bone synthesis and bone ingrowth.
Interaction of humic acids and humic-acid-like polymers with herpes simplex virus type 1
NASA Astrophysics Data System (ADS)
Klöcking, Renate; Helbig, Björn
The study was performed in order to compare the antiviral activity against herpes simplex virus type 1 (HSV-1) of synthetic humic-acid-like polymers to that of their low-molecular-weight basic compounds and naturally occurring humic acids (HA) in vitro. HA from peat water showed a moderate antiviral activity at a minimum effective concentration (MEC) of 20 µg/ml. HA-like polymers, i.e. the oxidation products of caffeic acid (KOP), hydrocaffeic acid (HYKOP), chlorogenic acid (CHOP), 3,4-dihydroxyphenylacetic acid (3,4-DHPOP), nordihydroguaretic acid (NOROP), gentisinic acid (GENOP), pyrogallol (PYROP) and gallic acid (GALOP), generally inhibit virus multiplication, although with different potency and selectivity. Of the substances tested, GENOP, KOP, 3,4-DHPOP and HYKOP with MEC values in the range of 2 to 10 µg/ml, proved to be the most potent HSV-1 inhibitors. Despite its lower antiviral potency (MEC 40 µg/ml), CHOP has a remarkable selectivity due to the high concentration of this polymer that is tolerated by the host cells (>640 µg/ml). As a rule, the antiviral activity of the synthetic compounds was restricted to the polymers and was not preformed in the low-molecular-weight basic compounds. This finding speaks in favour of the formation of antivirally active structures during the oxidative polymerization of phenolic compounds and, indirectly, of corresponding structural parts in different HA-type substances.
Effect of humic acid on ciprofloxacin removal by magnetic multifunctional resins
Wang, Wei; Cheng, Jiade; Jin, Jing; Zhou, Qing; Ma, Yan; Zhao, Qingqing; Li, Aimin
2016-01-01
Background organic matter significantly influences the removal of emerging contaminants in natural water. In this work, the adsorption of ciprofloxacin (CPX) onto a series of magnetic multifunctional resins (GMA10-GMA90) in the presence and absence of humic acid (HA) was conducted to demonstrate the effect of HA. Both hydrophobic and ion exchange interactions contributed to CPX adsorption. Negative charge-assisted hydrogen bonds also participated in the adsorption process, resulting in the high adsorption amount of anionic CPX onto the negatively charged GMA30 under basic solutions. HA could impact CPX adsorption not only as a competitive adsorbate but also as an additional adsorbent. At pH 5.6, the additional adsorption sites provided by adsorbed HA molecules on the resins dominated and thus facilitated the adsorption process. While at pH 10, HA inhibited the adsorption of CPX by directly competing for ion exchange sites and coexisting with CPX in the solution. The ratio of the amount of CPX adsorbed by dissolved HA to that by the resin reached as high as 1.61 for GMA90. The adsorbed HA molecules onto the resins could provide additional adsorption sites for CPX as proven by the enhanced CPX adsorption in HA-preloading systems at pH 5.6. PMID:27464502
Effect of humic acid on ciprofloxacin removal by magnetic multifunctional resins
NASA Astrophysics Data System (ADS)
Wang, Wei; Cheng, Jiade; Jin, Jing; Zhou, Qing; Ma, Yan; Zhao, Qingqing; Li, Aimin
2016-07-01
Background organic matter significantly influences the removal of emerging contaminants in natural water. In this work, the adsorption of ciprofloxacin (CPX) onto a series of magnetic multifunctional resins (GMA10-GMA90) in the presence and absence of humic acid (HA) was conducted to demonstrate the effect of HA. Both hydrophobic and ion exchange interactions contributed to CPX adsorption. Negative charge-assisted hydrogen bonds also participated in the adsorption process, resulting in the high adsorption amount of anionic CPX onto the negatively charged GMA30 under basic solutions. HA could impact CPX adsorption not only as a competitive adsorbate but also as an additional adsorbent. At pH 5.6, the additional adsorption sites provided by adsorbed HA molecules on the resins dominated and thus facilitated the adsorption process. While at pH 10, HA inhibited the adsorption of CPX by directly competing for ion exchange sites and coexisting with CPX in the solution. The ratio of the amount of CPX adsorbed by dissolved HA to that by the resin reached as high as 1.61 for GMA90. The adsorbed HA molecules onto the resins could provide additional adsorption sites for CPX as proven by the enhanced CPX adsorption in HA-preloading systems at pH 5.6.
What is Basic Research? Insights from Historical Semantics.
Schauz, Désirée
2014-01-01
For some years now, the concept of basic research has been under attack. Yet although the significance of the concept is in doubt, basic research continues to be used as an analytical category in science studies. But what exactly is basic research? What is the difference between basic and applied research? This article seeks to answer these questions by applying historical semantics. I argue that the concept of basic research did not arise out of the tradition of pure science. On the contrary, this new concept emerged in the late 19th and early 20th centuries, a time when scientists were being confronted with rising expectations regarding the societal utility of science. Scientists used the concept in order to try to bridge the gap between the promise of utility and the uncertainty of scientific endeavour. Only after 1945, when United States science policy shaped the notion of basic research, did the concept revert to the older ideals of pure science. This revival of the purity discourse was caused by the specific historical situation in the US at that time: the need to reform federal research policy after the Second World War, the new dimension of ethical dilemmas in science and technology during the atomic era, and the tense political climate during the Cold War.
Craft-Art as a Basis for Human Activity
ERIC Educational Resources Information Center
Karppinen, Seija
2008-01-01
This article based on my doctoral thesis examines the Basic Arts Education system in Finland, focusing on Basic Crafts Education and its description through action concepts. The main task of the study was to create a concept model. In the first part of the study a concept map was created from the practice of Basic Crafts Education. The aim of the…
ERIC Educational Resources Information Center
Hansen, W. Lee; And Others
A concise framework of basic concepts and generalizations for teaching economics for K-12 students is presented. The guide summarizes the basic structure and substance of economics and lists and describes economic concepts. Standard guidelines are provided to help school systems integrate economics into their on-going courses of study. Designed to…
Boehm Test of Basic Concepts-Revised. Review.
ERIC Educational Resources Information Center
Padula, Janice
1988-01-01
The manual for the Boehm Test of Basic Concepts-Revised (1986) is reviewed. The test measures a child's knowledge of relational concepts. The revised version, eliminating some imperfections of the original, will continue to be a useful test of verbal concept acquisition. Cautions necessary while using the test are discussed. (SLD)
[The usefullness of hyaluronate injection in patients with RA].
Saito, Seiji
2003-06-01
In this seminar, we reported the usefulness of hyaluronate injection in clinical application with patients of RA. In basic research areas, however, the mechanisms responsible for the reported beneficial clinical effects of these treatments remain unclear. There is accumulating experimental evidence to show that the receptors of HA, eg, CD-44, accelerate the inflammation of joint. Administration high molecular weight HA may modulate CD-44 sensitive macromolecular in joint inflammation in part to reduce the activity of proteinases such as MMP-9.
Effect of Acid-Base Equilibrium on Absorption Spectra of Humic acid in the Presence of Copper Ions
NASA Astrophysics Data System (ADS)
Lavrik, N. L.; Mulloev, N. U.
2014-03-01
The reaction between humic acid (HA, sample IHSS) and a metal ion (Cu2+) that was manifested as absorption bands in the range 210-350 nm was recorded using absorption spectroscopy. The reaction was found to be more effective as the pH increased. These data were interpreted in the framework of generally accepted concepts about the influence of acid-base equilibrium on the dissociation of salts, according to which increasing the solution pH increases the concentration of HA anions. It was suggested that [HA-Cu2+] complexes formed.
Drawing on student knowledge of neuroanatomy and neurophysiology.
Slominski, Tara N; Momsen, Jennifer L; Montplaisir, Lisa M
2017-06-01
Drawings are an underutilized assessment format in Human Anatomy and Physiology (HA&P), despite their potential to reveal student content understanding and alternative conceptions. This study used student-generated drawings to explore student knowledge in a HA&P course. The drawing tasks in this study focused on chemical synapses between neurons, an abstract concept in HA&P. Using two preinstruction drawing tasks, students were asked to depict synaptic transmission and summation. In response to the first drawing task, 20% of students ( n = 352) created accurate representations of neuron anatomy. The remaining students created drawings suggesting an inaccurate or incomplete understanding of synaptic transmission. Of the 208 inaccurate student-generated drawings, 21% depicted the neurons as touching. When asked to illustrate summation, only 10 students (roughly 4%) were able to produce an accurate drawing. Overall, students were more successful at drawing anatomy (synapse) than physiology (summation) before formal instruction. The common errors observed in student-generated drawings indicate students do not enter the classroom as blank slates. The error of "touching" neurons in a chemical synapse suggests that students may be using intuitive or experiential knowledge when reasoning about physiological concepts. These results 1 ) support the utility of drawing tasks as a tool to reveal student content knowledge about neuroanatomy and neurophysiology; and 2 ) suggest students enter the classroom with better knowledge of anatomy than physiology. Collectively, the findings from this study inform both practitioners and researchers about the prevalence and nature of student difficulties in HA&P, while also demonstrating the utility of drawing in revealing student knowledge. Copyright © 2017 the American Physiological Society.
Zhang, Min; Cai, Shu; Zhang, Feiyang; Xu, Guohua; Wang, Fengwu; Yu, Nian; Wu, Xiaodong
2017-06-01
In this work, a magnesium phytic acid/hydroxyapatite composite coating was successfully prepared on AZ31 magnesium alloy substrate by chemical conversion deposition technology with the aim of improving its corrosion resistance and bioactivity. The influence of hydroxyapatite (HA) content on the microstructure and corrosion resistance of the coatings was investigated. The results showed that with the increase of HA content in phytic acid solution, the cracks on the surface of the coatings gradually reduced, which subsequently improved the corrosion resistance of these coated magnesium alloy. Electrochemical measurements in simulated body fluid (SBF) revealed that the composite coating with 45 wt.% HA addition exhibited superior surface integrity and significantly improved corrosion resistance compared with the single phytic acid conversion coating. The results of the immersion test in SBF showed that the composite coating could provide more effective protection for magnesium alloy substrate than that of the single phytic acid coating and showed good bioactivity. Magnesium phytic acid/hydroxyapatite composite, with the desired bioactivity, can be synthesized through chemical conversion deposition technology as protective coatings for surface modification of the biodegradable magnesium alloy implants. The design idea of the new type of biomaterial is belong to the concept of "third generation biomaterial". Corrosion behavior and bioactivity of coated magnesium alloy are the key issues during implantation. In this study, preparation and corrosion behavior of magnesium phytic acid/hydroxyapatite composite coatings on magnesium alloy were studied. The basic findings and significance of this paper are as follows: 1. A novel environmentally friendly, homogenous and crack-free magnesium phytic acid/hydroxyapatite composite coating was fabricated on AZ31 magnesium alloy via chemical conversion deposition technology with the aim of enhancing its corrosion resistance and bioactivity. The chemical conversion coatings, which are formed through the reaction between the substrate and the environment, have attracted increasing attention owing to the relative low treatment temperature, favorable bonding to substrate and simple implementation process. 2. With the increasing of hydroxyapatite (HA) content, the crack width in the composite coatings and the thickness of the coatings exhibit obviously decreased. The reason is probably that when adding HA into the phytic acid solution, the amount of active hydroxyl groups in the phytic acid are reduced via forming the coordination bond between P-OH groups from phytic acid and P-OH groups from the surface of HA, thus decreasing the coating thickness and hydrogen formation, as well as avoiding coating cracking. 3. By adjusting the HA content to 45 wt.%, a dense and relatively smooth composite coating with ~1.4 μm thickness is obtained on magnesium alloy, and exhibits high corrosion resistance and good bioactivity when compared with the single phytic acid conversion coating.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sun, Xiangjie; Belser, Jessica A.; Tumpey, Terrence M., E-mail: tft9@cdc.gov
In 2012, an avian influenza A H7N3 (A/Mexico/InDRE7218/2012; Mx/7218) virus was responsible for two confirmed cases of human infection and led to the death or culling of more than 22 million chickens in Jalisco, Mexico. Interestingly, this virus acquired an 8-amino acid (aa)-insertion (..PENPK-DRKSRHRR-TR/GLF) near the hemagglutinin (HA) cleavage site by nonhomologous recombination with host rRNA. It remains unclear which specific residues at the cleavage site contribute to the virulence of H7N3 viruses in mammals. Using loss-of-function approaches, we generated a series of cleavage site mutant viruses by reverse genetics and characterized the viruses in vitro and in vivo. Wemore » found that the 8-aa insertion and the arginine at position P4 of the Mx/7218 HA cleavage site are essential for intracellular HA cleavage in 293T cells, but have no effect on the pH of membrane fusion. However, we identified a role for the histidine residue at P5 position in viral fusion pH. In mice, the 8-aa insertion is required for Mx/7218 virus virulence; however, the basic residues upstream of the P4 position are dispensable for virulence. Overall, our study provides the first line of evidence that the insertion in the Mx/7218 virus HA cleavage site confers its intracellular cleavability, and consequently contributes to enhanced virulence in mice. - Highlights: • An avian influenza H7N3 virus acquired a unique 8-amino acid (aa) insertion. • The role of specific basic residues in the HA insertion in viral pathogenesis was determined. • In mice, the 8-aa insertion is required for H7N3 virus virulence. • The R residue at position P4 is essential for HA intracellular cleavage and virus virulence.« less
ERIC Educational Resources Information Center
Vink, Sylvia; van Tartwijk, Jan; Verloop, Nico; Gosselink, Manon; Driessen, Erik; Bolk, Jan
2016-01-01
To determine the content of integrated curricula, clinical concepts and the underlying basic science concepts need to be made explicit. Preconstructed concept maps are recommended for this purpose. They are mainly constructed by experts. However, concept maps constructed by residents are hypothesized to be less complex, to reveal more tacit basic…
ERIC Educational Resources Information Center
Durukan, Ümmü Gülsüm; Saglam-Arslan, Aysegül
2015-01-01
Learners face a variety of concepts during the instructional process they experience. These concepts are mostly introduced by teachers; thus, the competences of teachers in terms of teaching concepts are vitally important. The aim of this study is to detect the understanding levels of teacher candidates about basic astronomy concepts. The method…
Zermane, Faiza; Cheknane, Benamar; Basly, Jean Philippe; Bouras, Omar; Baudu, Michel
2013-04-01
Effect of humic acids (HAs), macromolecules from natural organic matter, on the adsorption of Basic Yellow 28 is the aim of the present work. Three adsorbents were investigated in this study: an iron organo-inorgano pillared clay and two synthetic Hydrous Iron Oxide (Goethite and HFO). The surface charge was positive in the pH range of this study for the pillared clay; in contrast, it changes from positive to negative when the pH value increased (pH>9) for the two (oxy)hydroxides. Pseudo-first order kinetic rate constants and adsorption capacities increase from humic acid to BY 28. Adsorption isotherms of BY 28 and HA in single component were analysed using the Freundlich equation. Adsorption capacities increased sharply when the pH value of the dye solution was raised from 3 to 9. Increasing the pH medium from 3 to 9 reduces the HA adsorption capacities onto Fe-SMPM and iron oxyhydroxides, respectively. Fitting between measured and predicted sorption capacities of BY 28 and HA in a binary component system indicates that the Sheindorf-Rebuhn-Sheintuch (SRS) model, an extended Freundlich model, is able to describe the simultaneous adsorption of BY 28 and HA. Humic acids favourably affect the adsorption of BY 28, and a cooperative mechanism could be suggested. The synergetic effect existing between BY 28 and HA is shown by the interaction coefficients η12, which are generally high and increase with pH. Some phenomena have been advanced to explain this mechanism. Copyright © 2012 Elsevier Inc. All rights reserved.
Taylor, Steven; McKay, Dean; Crowe, Katherine B.; Abramowitz, Jonathan S.; Conelea, Christine A.; Calamari, John E.; Sica, Claudio
2014-01-01
Contemporary models of obsessive-compulsive disorder emphasize the importance of harm avoidance (HA) and related dysfunctional beliefs as motivators of obsessive-compulsive (OC) symptoms. Recently, there has been a resurgence of interest in Janet’s (1908) concept of incompleteness (INC) as another potentially important motivator. Contemporary investigators define INC as the sense that one’s actions, intentions, or experiences have not been properly achieved. Janet defined INC more broadly to include alexithymia, depersonalization, derealization, and impaired psychological mindedness. We conducted two studies to address four issues: (a) the clinical correlates of INC; (b) whether INC and HA are distinguishable constructs; (c) whether INC predicts OC symptoms after controlling for HA; and (d) the relative merits of broad versus narrow conceptualizations of INC. Study 1 was a meta-analysis of the clinical correlates of narrowly defined INC (16 studies, N=5,940). INC was correlated with all types of OC symptoms, and was more strongly correlated with OC symptoms than with general distress. Study 2 (N=534 nonclinical participants) showed that: (a) INC and HA were strongly correlated but factor analytically distinguishable; (b) INC statistically predicted all types of OC symptoms even after controlling for HA; and (c) narrow INC was most strongly correlated with OC symptoms whereas broad INC was most strongly correlated with general distress. Although the findings are limited by being correlational in nature, they support the hypothesis that INC, especially in its narrow form, is a motivator of OC symptoms. PMID:24491200
Wide-range stiffness gradient PVA/HA hydrogel to investigate stem cell differentiation behavior.
Oh, Se Heang; An, Dan Bi; Kim, Tae Ho; Lee, Jin Ho
2016-04-15
Although stiffness-controllable substrates have been developed to investigate the effect of stiffness on cell behavior and function, the use of separate substrates with different degrees of stiffness, substrates with a narrow range stiffness gradient, toxicity of residues, different surface composition, complex fabrication procedures/devices, and low cell adhesion are still considered as hurdles of conventional techniques. In this study, a cylindrical polyvinyl alcohol (PVA)/hyaluronic acid (HA) hydrogel with a wide-range stiffness gradient (between ∼20kPa and ∼200kPa) and cell adhesiveness was prepared by a liquid nitrogen (LN2)-contacting gradual freezing-thawing method that does not use any additives or specific devices to produce the stiffness gradient hydrogel. From an in vitro cell culture using the stiffness gradient PVA/HA hydrogel, it was observed that human bone marrow mesenchymal stem cells have favorable stiffness ranges for induction of differentiation into specific cell types (∼20kPa for nerve cell, ∼40kPa for muscle cell, ∼80kPa for chondrocyte, and ∼190kPa for osteoblast). The PVA/HA hydrogel with a wide range of stiffness spectrum can be a useful tool for basic studies related with the stem cell differentiation, cell reprogramming, cell migration, and tissue regeneration in terms of substrate stiffness. It is postulated that the stiffness of the extracellular matrix influences cell behavior. To prove this concept, various techniques to prepare substrates with a stiffness gradient have been developed. However, the narrow ranges of stiffness gradient and complex fabrication procedures/devices are still remained as limitations. Herein, we develop a substrate (hydrogel) with a wide-range stiffness gradient using a gradual freezing-thawing method which does not need specific devices to produce a stiffness gradient hydrogel. From cell culture experiments using the hydrogel, it is observed that human bone marrow mesenchymal stem cells have favorable stiffness ranges for induction of differentiation into specific cell types (∼20kPa for nerve, ∼40kPa for muscle, ∼80kPa for cartilage, and ∼190kPa for bone in our hydrogel system). Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Mueller, Andrea; Fujioka-Kobayashi, Masako; Mueller, Heinz-Dieter; Lussi, Adrian; Sculean, Anton; Schmidlin, Patrick R; Miron, Richard J
2017-05-01
Hyaluronic acid (HA) is a natural constituent of connective tissues and plays an important role in their development, maintenance, and regeneration. Recently, HA has been shown to improve wound healing. However, no basic in vitro study to date has investigated its mode of action. Therefore, the purpose of this study was to examine morphological changes of dentin surfaces following HA coating and thereafter investigate the influence of periodontal ligament (PDL) cell survival, attachment, and spreading to dentin discs. HA was coated onto dentin discs utilizing either non-cross-linked (HA) or cross-linked (HA cl) delivery systems. Morphological changes to dentin discs were then assessed using scanning electron microscopy (SEM). Thereafter, human PDL cells were seeded under three in vitro conditions including (1) dilution of HA (1:100), (2) dilution of HA (1:10), and (3) HA coated directly to dentin discs. Samples were then investigated for PDL cell survival, attachment, and spreading using a live/dead assay, cell adhesion assay, and SEM imaging, respectively. While control dentin discs demonstrated smooth surfaces both at low and high magnification, the coating of HA altered surface texture of dentin discs by increasing surface roughness. HA cl further revealed greater surface texture/roughness likely due to the cross-linking carrier system. Thereafter, PDL cells were seeded on control and HA coated dentin discs and demonstrated a near 100 % survival rate for all samples demonstrating high biocompatibility of HA at dilutions of both 1:100 and 1:10. Interestingly, non-cross-linked HA significantly increased cell numbers at 8 h, whereas cross-linked HA improved cell spreading as qualitatively assessed by SEM. The results from the present study demonstrate that both carrier systems for HA were extremely biocompatible and demonstrated either improved cell numbers or cell spreading onto dentin discs. Future in vitro and animal research is necessary to further characterize the optimal delivery system of HA for improved clinical use. HA is a highly biocompatible material that may improve PDL cell attachment or spreading on dentin.
The Effective Concepts on Students' Understanding of Chemical Reactions and Energy
ERIC Educational Resources Information Center
Ayyildiz, Yildizay; Tarhan, Leman
2012-01-01
The purpose of this study was to determine the relationship between the basic concepts related to the unit of "Chemical Reactions and Energy" and the sub-concepts underlying for meaningful learning of the unit and to investigate the effectiveness of them on students' learning achievements. For this purpose, the basic concepts of the unit…
Unders and Overs: Using a Dice Game to Illustrate Basic Probability Concepts
ERIC Educational Resources Information Center
McPherson, Sandra Hanson
2015-01-01
In this paper, the dice game "Unders and Overs" is described and presented as an active learning exercise to introduce basic probability concepts. The implementation of the exercise is outlined and the resulting presentation of various probability concepts are described.
Radiological Dispersion Devices and Basic Radiation Science
ERIC Educational Resources Information Center
Bevelacqua, Joseph John
2010-01-01
Introductory physics courses present the basic concepts of radioactivity and an overview of nuclear physics that emphasizes the basic decay relationship and the various types of emitted radiation. Although this presentation provides insight into radiological science, it often fails to interest students to explore these concepts in a more rigorous…
ERIC Educational Resources Information Center
Trumper, Ricardo
2006-01-01
In view of students' alternative conceptions about basic concepts in astronomy, we conducted a series of constructivist activities with future elementary and junior high school teachers aimed at changing their conceptions about the cause of seasonal changes, and of several characteristics of the Sun-Earth-Moon relative movements like Moon phases,…
Lee, Yu-Na; Hwang, Hye Suk; Kim, Min-Chul; Lee, Young-Tae; Cho, Min-Kyoung; Kwon, Young-Man; Lee, Jong Seok; Plemper, Richard K.; Kang, Sang-Moo
2014-01-01
Respiratory syncytial virus (RSV) is one of the most important causes for viral lower respiratory tract disease in humans. There is no licensed RSV vaccine. Here, we generated recombinant influenza viruses (PR8/RSV.HA-G) carrying the chimeric constructs of hemagglutinin (HA) and central conserved-domains of the RSV G protein. PR8/RSV.HA-G virus showed lower pathogenicity without compromising immunogenicity in mice. Single intranasal inoculation of mice with PR8/RSV.HA-G induced IgG2a isotype dominant antibodies and RSV neutralizing activity. Mice with single intranasal inoculation of PR8/RSV.HA-G were protected against RSV infection as evidenced by significant reduction of lung viral loads to a detection limit upon RSV challenge. PR8/RSV.HA-G inoculation of mice did not induce pulmonary eosinophilia and inflammation upon RSV infection. These findings support a concept that recombinant influenza viruses carrying the RSV G conserved-domain can be developed as a promising RSV vaccine candidate without pulmonary disease. PMID:25553517
ERIC Educational Resources Information Center
Qudah, Ahmad Hassan
2016-01-01
The study aimed to detect the effect of using an educational site on the Internet in the collection of bachelor's students in the course of basic concepts in mathematics at Al al-Bayt University, and the study sample consisted of all students in the course basic concepts in mathematics in the first semester of the academic year 2014/2015 and the…
Internet Protocol Handbook. Volume 4. The Domain Name System (DNS) handbook
1989-08-01
Mockapetris [Page 1] 4-11 INTERNET PROTOCOL HA TDBOOK - Voue Four 1989 RFC 1034 Domain Concepts and Facilities November 1987 bandwidth consumed in distributing...Domain Names- Concepts and Facilities KFC 1034 RFC 1034 Domain Concepts and Facilities November 1’)87 - Queries contain a bit called recursion desired...during periodic sweeps to reclaim the memory consumed by old RRS. Mockapetris [Page 33] 4-43 INTERNET PROTOCOL HANDBOOK - Volume Four 1989 RFC 1034
Development of a Multi-experience Approach in Introductory Soil and Vegetation Geography Courses.
ERIC Educational Resources Information Center
Limbird, Arthur
1982-01-01
Describes an introductory college level course in soil and vegetation which uses lecture, audiovisual tutorial, individualized instruction, field trips, films, and games. The course consists of three segments: basic concepts of soils, basic concepts of plants, and soil and vegetation concepts in a spatial context. (KC)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Liuyun, Jiang, E-mail: jlytxg@163.com; Chengdong, Xiong; Lixin, Jiang
Graphical abstract: Effect of n-HA content on the isothermal crystallization, morphology and mechanical property of n-HA/PLGA composites was studied in details. The results showed that the addition of higher content of g-n-HA was favorable to promote the crystallization better in g-n-HA/PLGA composites, but it could also cause more agglomeration in PLGA matrix, as a result of worse mechanical properties, and the addition content of 3 wt% g-n-HA to PLGA matrix was an appropriate proportion, which had the highest bending strength among these g-n-HA/PLGA composites, and it might be potential to be used in biomedical fields in future. Highlights: ► Themore » effect of n-HA content on the n-HA/PLGA composites was studied in detail. ► Isothermal crystallization, microstructure and mechanical property were studied. ► The relation between n-HA content and properties of n-HA/PLGA composite was found. ► An appropriate proportion of n-HA in n-HA/PLGA composite was obtained. - Abstract: A serials of g-n-HA/PLGA composites with surface-modified g-n-HA of 1%, 3%, 6%, 10% and 15% in weight were prepared by solution mixing. The isothermal crystallization, morphology and mechanical property of g-n-HA/PLGA composites were investigated by differential scanning calorimeter (DSC), scanning electron microscope (SEM) and electromechanical universal tester. The results showed that Avrami equation was suitable for describing the isothermal crystallization process in this system, and the crystallization rate of g-n-HA/PLGA composites containing more than 3 wt% g-n-HA was basically accord with the relational expression of T{sub 110} {sub °C} > T{sub 105°C} > T{sub 115°C} > T{sub 120°C}. Moreover, at the same Tc, crystallization rate was greatly enhanced with the increasing of g-n-HA acting as nucleate. However, the addition of higher content of g-n-HA would cause more agglomeration in PLGA matrix, so that the mechanical properties of g-n-HA/PLGA composites would gradually decrease. In conclusion, the addition of higher content of g-n-HA was favorable to promote the crystallization better in g-n-HA/PLGA composites, but it could also cause more agglomeration in PLGA matrix, result in worse mechanical properties, and the addition content of 3 wt% g-n-HA to PLGA matrix was an appropriate proportion, which had the highest bending strength among these g-n-HA/PLGA composites, and it might be potential to be used in biomedical fields in future.« less
The effect of humic acid on uranyl sorption onto bentonite at trace uranium levels.
Ivanov, Peter; Griffiths, Tamara; Bryan, Nick D; Bozhikov, Gospodin; Dmitriev, Serguei
2012-11-01
The effect of humic acid (HA) on U(VI) sorption on bentonite was studied in batch experiments at room temperature and ambient atmosphere at a (237)U(VI) concentration of 8.4 × 10(-11) M and HA concentration of 100 mg L(-1). The distribution of U(VI) between the liquid and solid phases was studied as a function of pH and ionic strength both in the absence and presence of HA. It was shown that the uranyl sorption on bentonite is strongly dependent on pH and the presence of humics, and the effect of the addition order was negligible. In the absence of HA an enhancement in the uptake with increasing pH was observed and a sharp sorption edge was found to take place between pH 3.2 and 4.2. The presence of HA slightly increases uranium(VI) sorption at low pH and curtails it at moderate pH, compared to the absence of HA. In the basic pH range for both the presence and absence of HA the sorption of uranium is significantly reduced, which could be attributed to the formation of soluble uranyl carbonate complexes. The influence of ionic strength on U(VI) and HA uptake by bentonite were investigated in the range of 0.01-1.0 M, and while there was an enhancement in the sorption of humic acid with increasing ionic strength, no significant effect of the ionic strength on the U(VI) sorption was observed in both the absence and presence of HA.
Bennett, Ryan P; Presnyak, Vladimir; Wedekind, Joseph E; Smith, Harold C
2008-03-21
Human APOBEC3G (hA3G) is a host factor that defends against HIV-1 as well as other exogenous retroviruses and endogenous retroelements. To this end, hA3G is restricted to the cytoplasm of T lymphocytes where it interacts with viral RNA and proteins to assemble with viral particles causing a post-entry block during reverse transcription. hA3G also exhibits a mechanism to inhibit the reverse transcription of retroelements by RNA binding and sequestration into mRNA processing centers in the cytoplasm. We have determined that the molecular basis for this specialized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and sufficient to restrict wild-type hA3G and chimeric constructs to the cytoplasm. The CRS resides within amino acids 113-128 and is embedded within a basic flanking sequence and does not require RNA binding to retain hA3G in the cytoplasm. Paralogs of hA3G that have nuclear or cytoplasmic distributions differ from hA3G within the region encompassing the CRS motif with respect to charge and amino acid composition. We propose that the CRS enables hA3G to interact with cytoplasmic factors, and thereby enables hA3G to serve in host cell defense by restricting an antiviral sentinel to the cytoplasm. The CRS lies in a region involved in both Gag and Vif interactions; therefore, identification of this motif has important implications for the design of therapeutics that target HIV-1 while maintaining antiviral and cellular functions.
Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase.
Chang, Lei; Duy, Do Le; Mébarek, Saida; Popowycz, Florence; Pellet-Rostaing, Stéphane; Lemaire, Marc; Buchet, René
2011-04-15
Pathological calcifications induced by deposition of basic phosphate crystals or hydroxyapatite (HA) on soft tissues are a large family of diseases comprising of ankylosing spondylitis (AS), end-stage osteoarthritis (OA) and vascular calcification. High activity of tissue non-specific alkaline phosphatase (TNAP) is a hallmark of pathological calcifications induced by HA deposition. The use of TNAP inhibitor is a possible therapeutic option to address calcific diseases produced by HA deposition on soft tissues. We report the synthesis of a series of thiopheno-imidazo[2,1-b]thiazole derivatives which were evaluated as potential inhibitors of TNAP displaying a large range of IC(50) at pH 10.4 (from 42±13 μM to more than 800 μM). Copyright © 2011. Published by Elsevier Ltd.
Computer Literacy Project. A General Orientation in Basic Computer Concepts and Applications.
ERIC Educational Resources Information Center
Murray, David R.
This paper proposes a two-part, basic computer literacy program for university faculty, staff, and students with no prior exposure to computers. The program described would introduce basic computer concepts and computing center service programs and resources; provide fundamental preparation for other computer courses; and orient faculty towards…
Learning Genetics with Paper Pets
ERIC Educational Resources Information Center
Finnerty, Valerie Raunig
2006-01-01
By the end of the eighth grade, students are expected to have a basic understanding of the mechanism of basic genetic inheritance. However, these concepts can be difficult to teach. In this article, the author introduces a new learning tool that will help facilitate student learning and enthusiasm to the basic concepts of genetic inheritance. This…
Suguitan, Amorsolo L; Marino, Michael P; Desai, Purvi D; Chen, Li-Mei; Matsuoka, Yumiko; Donis, Ruben O; Jin, Hong; Swayne, David E; Kemble, George; Subbarao, Kanta
2009-12-20
A recombinant live attenuated influenza virus DeltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the DeltaH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the DeltaH5N1 vaccine in mice.
Suguitan, Amorsolo L.; Marino, Michael P.; Desai, Purvi D.; Chen, Li-Mei; Matsuoka, Yumiko; Donis, Ruben O.; Jin, Hong; Swayne, David E.; Kemble, George; Subbarao, Kanta
2009-01-01
A recombinant live attenuated influenza virus ΔH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the ΔH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the ΔH5N1 vaccine in mice. PMID:19833372
[Biometric bases: basic concepts of probability calculation].
Dinya, E
1998-04-26
The author gives or outline of the basic concepts of probability theory. The bases of the event algebra, definition of the probability, the classical probability model and the random variable are presented.
Identifying Students' Conceptions of Basic Principles in Sequence Stratigraphy
ERIC Educational Resources Information Center
Herrera, Juan S.; Riggs, Eric M.
2013-01-01
Sequence stratigraphy is a major research subject in the geosciences academia and the oil industry. However, the geoscience education literature addressing students' understanding of the basic concepts of sequence stratigraphy is relatively thin, and the topic has not been well explored. We conducted an assessment of 27 students' conceptions of…
Students' Conceptions of Function Transformation in a Dynamic Mathematical Environment
ERIC Educational Resources Information Center
Daher, Wajeeh; Anabousy, Ahlam
2015-01-01
The study of function transformations helps students understand the function concept which is a basic and main concept in mathematics, but this study is problematic to school students as well as college students, especially when transformations are performed on non-basic functions. The current research tried to facilitate grade 9 students'…
Outline of Basic Concepts in Anthropology. Publication No. 1.
ERIC Educational Resources Information Center
Georgia Univ., Athens. Anthropology Curriculum Project.
This teaching aid outlines basic anthropological concepts described in the various units of the Anthropology Curriculum Project. The outline of important concepts to be learned is intended to be used by the teacher in conjunction with the other instructional materials in each unit. The introduction defines anthropology, its branches and purposes.…
A Concept Transformation Learning Model for Architectural Design Learning Process
ERIC Educational Resources Information Center
Wu, Yun-Wu; Weng, Kuo-Hua; Young, Li-Ming
2016-01-01
Generally, in the foundation course of architectural design, much emphasis is placed on teaching of the basic design skills without focusing on teaching students to apply the basic design concepts in their architectural designs or promoting students' own creativity. Therefore, this study aims to propose a concept transformation learning model to…
Emotional intelligence and glycemic management among type I diabetes patients.
Zysberg, Leehu; Bar Yoseph, Tal; Goldman, Mor
2017-02-01
Type 1 diabetes is a lifelong physical and emotional challenge. The concept of emotional intelligence may offer better understanding of personal resources facilitating management of such challenges. We therefore hypothesized that emotional intelligence will negatively associate with two measures of diabetic management: HA1c and blood sugar levels. A total of 78 young adults with type 1 diabetes mellitus reported their last HA1c test result and their blood sugar level, as well as demographics and took the audio-visual test of emotional intelligence. The results showed a negative association between emotional intelligence and HA1c and marginal results in the same direction with blood sugar levels even when controlling for demographics.
Basic Measurement and Related Careers: Level C.
ERIC Educational Resources Information Center
Ohio State Univ., Columbus. Center for Vocational and Technical Education.
The teaching guide, part of a series of four, consists of learning experiences for use at the levels of grades 3 and 4 in mathematics. It focuses on the basic concepts of measurement and developing measurement skills in the early grades. It progresses to the concept of measurement by comparison and to developing basic volume measurement skills.…
The Effect of Home Related Science Activities on Students' Performance in Basic Science
ERIC Educational Resources Information Center
Obomanu, B. J.; Akporehwe, J. N.
2012-01-01
Our study investigated the effect of utilizing home related science activities on student's performance in some basic science concepts. The concepts considered were heart energy, ecology and mixtures. The sample consisted of two hundred and forty (240) basic junior secondary two (BJSS11) students drawn from a population of five thousand and…
Using a Thyroid Case Study and Error Plausibility to Introduce Basic Lab Skills
ERIC Educational Resources Information Center
Browning, Samantha; Urschler, Margaret; Meidl, Katherine; Peculis, Brenda; Milanick, Mark
2017-01-01
We describe a 3-hour session that provides students with the opportunity to review basic lab concepts and important techniques using real life scenarios. We began with two separate student-engaged discussions to remind/reinforce some basic concepts in physiology and review calculations with respect to chemical compounds. This was followed by…
Improving regional development through aerotropolis conceptual design
NASA Astrophysics Data System (ADS)
Berawi, M. A.; Miraj, P.; Adhityo, A. D.; Sakti, G. R.
2017-12-01
The airport has a great role in the modern life and has been shown significant influence in shaping the layout and structure of the city. Along with the high growth of passenger and logistics activities, the airport has been developed into a city-based airport. Although airports in the world have commonly implemented this concept, most cities in Indonesia are not familiar and prefer the traditional approach by locating airport far from the city with limited consideration of urban expansion. This research will conduct a study to develop the most suitable model of the aero - city. The study will use a combination of quantitative and qualitative approaches. The results shows that Aerotropolis development required 1,446.9 Ha and divided into four components. Airport use 53.21% of the area for about 770 Ha, an industrial zone about 430.6 Ha (29.76%), Mixed - use area about 101.6% (7.03%) and supporting infrastructure about 144.7 Ha (10%).
Finding the "A-Ha" Moment: An Exploration into HE in FE Teacher Self-Concept
ERIC Educational Resources Information Center
Kadi-Hanifi, Karima; Keenan, John
2016-01-01
Five teachers of higher education (HE)-level courses working in the further education (FE) sector recalled critical moments which helped to form their self-concepts. The researchers used life history method to encourage the teachers to be open about their lives and how they formed their personal and professional selves. Three common themes were…
Schultze-Lutter, F
2016-12-01
The early detection of psychoses has become increasingly relevant in research and clinic. Next to the ultra-high risk (UHR) approach that targets an immediate risk of developing frank psychosis, the basic symptom approach that targets the earliest possible detection of the developing disorder is being increasingly used worldwide. The present review gives an introduction to the development and basic assumptions of the basic symptom concept, summarizes the results of studies on the specificity of basic symptoms for psychoses in different age groups as well as on studies of their psychosis-predictive value, and gives an outlook on future results. Moreover, a brief introduction to first recent imaging studies is given that supports one of the main assumptions of the basic symptom concept, i. e., that basic symptoms are the most immediate phenomenological expression of the cerebral aberrations underlying the development of psychosis. From this, it is concluded that basic symptoms might be able to provide important information on future neurobiological research on the etiopathology of psychoses. © Georg Thieme Verlag KG Stuttgart · New York.
"Blame" Concept in Phraseology: Cognitive-Semantic Aspect (Based on the French Language)
ERIC Educational Resources Information Center
Zalavina, Tatyana Y.; Kisel, Olesya V.
2016-01-01
Phraseology is one of the basic and most important objects of study in cognitive linguistics. The article deals with verbal fixed phrases in their correlation with the cognitive structure of knowledge--a concept. The used definitional analysis method to identify the basic notions of the conceptual content of the concept of blame and basic…
ERIC Educational Resources Information Center
Trumper, Ricardo
2006-01-01
Bearing in mind students' misconceptions about basic concepts in astronomy, the present study conducted a series of constructivist activities aimed at changing future elementary and junior high school teachers' conceptions about the cause of seasonal changes, and several characteristics of the Sun-Earth-Moon relative movements like Moon phases,…
ERIC Educational Resources Information Center
Yücel, Elif Özata; Özkan, Mulis
2015-01-01
In this study, we determined cognitive structures and misconceptions about basic ecological concepts by using "word association" tests on secondary school students, age between 12-14 years. Eighty-nine students participated in this study. Before WAT was generated, basic ecological concepts that take place in the secondary science…
Conceptual Hierarchies in a Flat Attractor Network
O’Connor, Christopher M.; Cree, George S.; McRae, Ken
2009-01-01
The structure of people’s conceptual knowledge of concrete nouns has traditionally been viewed as hierarchical (Collins & Quillian, 1969). For example, superordinate concepts (vegetable) are assumed to reside at a higher level than basic-level concepts (carrot). A feature-based attractor network with a single layer of semantic features developed representations of both basic-level and superordinate concepts. No hierarchical structure was built into the network. In Experiment and Simulation 1, the graded structure of categories (typicality ratings) is accounted for by the flat attractor-network. Experiment and Simulation 2 show that, as with basic-level concepts, such a network predicts feature verification latencies for superordinate concepts (vegetable
Li, C-H; Shi, L; Han, Q; Hu, H-L; Zhao, M-W; Tang, C-M; Li, S-P
2012-09-01
To explore biocontrol potential of 39 DAEB isolates (doubly antagonistic towards both Verticillium dahliae Kleb and Fusarium oxysporum) against verticillium wilt of cotton and to elucidate colonization and category characteristics of an endophytic bacterium with significant biocontrol activity. Thirty-nine antagonistic endophytic bacteria strains were tested for their ability to control verticillium wilt in cotton plants caused by a defoliating pathotype of V. dahliae 107 in cotton under controlled conditions. The biocontrol trial revealed that an endophytic bacterium, designated HA02, showed a significant biocontrol activity to V. dahliae 107. After cotton seedlings were inoculated with a gfp gene-tagged HA02 (HA02-gfp), HA02-gfp populations were higher in the root than in the stem; in addition, the HA02-gfp was distributed in the maturation zone of cotton root. Furthermore, HA02-gfp also colonized seedlings of maize, rape and soybean after the bacteria inoculation. Phylogenetic trees based on 16S rDNA sequences combined with morphological, physiological and identification showed that the bacterium belongs to the Enterobacter genus. Our results showed that only 1 of 39 DAEB isolates demonstrated more efficient biocontrol potential towards V. dahliae 107 in greenhouse and field trials. HA02-gfp mainly colonized cotton in roots. In addition, we quantitatively observed HA02 colonization in other hosts. HA02 belongs to the Enterobacter genus. This is the first study on biocontrol to defoliating pathotype of V. dahliae Kleb by endophytic bacteria. The HA02 showed effective biocontrol to V. dahliae 107 in greenhouse and field trials. Furthermore, we assessed the quantitative and qualitative colonization of HA02 in cotton seedlings. Our study provides basic information to further explore managing strategies to control this critical disease. © 2012 The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.
Transmission of Influenza A Viruses
Neumann, Gabriele; Kawaoka, Yoshihiro
2015-01-01
Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Widespread outbreaks (pandemics) are attributable to ‘novel’ viruses that possess a viral hemagglutinin (HA) gene to which humans lack immunity. After a pandemic, these novel viruses form stable virus lineages in humans and circulate until they are replaced by other novel viruses. The factors and mechanisms that facilitate virus transmission among hosts and the establishment of novel lineages are not completely understood, but the HA and basic polymerase 2 (PB2) proteins are thought to play essential roles in these processes by enabling avian influenza viruses to infect mammals and replicate efficiently in their new host. Here, we summarize our current knowledge of the contributions of HA, PB2, and other viral components to virus transmission and the formation of new virus lineages. PMID:25812763
ERIC Educational Resources Information Center
Busch, Phyllis S.
1985-01-01
Suggests simple ways to introduce students to the concept that the cell is the basic unit of structure of most organisms. Mentions materials for microscope study that are readily available and easy to handle, e.g., membranes from between the scales of the onion bulb, thin-leaved plants, pond water, and pollen. (JHZ)
Qiao, Fen; Luo, Lilian; Peng, Huan; Luo, Shujie; Huang, Wenkun; Cui, Jiangkuan; Li, Xin; Kong, Lingan; Jiang, Daohong; Chitwood, David J; Peng, Deliang
2016-01-01
Heterodera avenae and H. filipjevi are major parasites of wheat, reducing production worldwide. Both are sedentary endoparasitic nematodes, and their development and parasitism depend strongly on nutrients obtained from hosts. Secreted fatty acid- and retinol-binding (FAR) proteins are nematode-specific lipid carrier proteins used for nutrient acquisition as well as suppression of plant defenses. In this study, we obtained three novel FAR genes Ha-far-1 (KU877266), Ha-far-2 (KU877267), Hf-far-1 (KU877268). Ha-far-1 and Ha-far-2 were cloned from H. avenae, encoding proteins of 191 and 280 amino acids with molecular masses about 17 and 30 kDa, respectively and sequence identity of 28%. Protein Blast in NCBI revealed that Ha-FAR-1 sequence is 78% similar to the Gp-FAR-1 protein from Globodera pallida, while Ha-FAR-2 is 30% similar to Rs-FAR-1 from Radopholus similis. Only one FAR protein Hf-FAR-1was identified in H. filipjevi; it had 96% sequence identity to Ha-FAR-1. The three proteins are alpha-helix-rich and contain the conserved domain of Gp-FAR-1, but Ha-FAR-2 had a remarkable peptide at the C-terminus which was random-coil-rich. Both Ha-FAR-1 and Hf-FAR-1 had casein kinase II phosphorylation sites, while Ha-FAR-2 had predicted N-glycosylation sites. Phylogenetic analysis showed that the three proteins clustered together, though Ha-FAR-1 and Hf-FAR-1 adjoined each other in a plant-parasitic nematode branch, but Ha-FAR-2 was distinct from the other proteins in the group. Fluorescence-based ligand binding analysis showed the three FAR proteins bound to a fluorescent fatty acid derivative and retinol and with dissociation constants similar to FARs from other species, though Ha-FAR-2 binding ability was weaker than that of the two others. In situ hybridization detected mRNAs of Ha-far-1 and Ha-far-2 in the hypodermis. The qRT-PCR results showed that the Ha-far-1and Ha-far-2 were expressed in all developmental stages; Ha-far-1 expressed 70 times more than Ha-far-2 in all stages. The highest expression level of Ha-far-1 was observed in fourth-stage juvenile (J4), whereas the highest expression level of Ha-far-2 occurred in second-stage juvenile (J2). In conclusion, we have identified two novel far genes from H. avenae and one from H. filipjevi and have provided further indication that nematode far genes are present in a variety of nematode species, where the FAR proteins share similar basic structure, expression pattern and biochemical activities.
Fundamentals in Biostatistics for Research in Pediatric Dentistry: Part I - Basic Concepts.
Garrocho-Rangel, J A; Ruiz-Rodríguez, M S; Pozos-Guillén, A J
The purpose of this report was to provide the reader with some basic concepts in order to better understand the significance and reliability of the results of any article on Pediatric Dentistry. Currently, Pediatric Dentists need the best evidence available in the literature on which to base their diagnoses and treatment decisions for the children's oral care. Basic understanding of Biostatistics plays an important role during the entire Evidence-Based Dentistry (EBD) process. This report describes Biostatistics fundamentals in order to introduce the basic concepts used in statistics, such as summary measures, estimation, hypothesis testing, effect size, level of significance, p value, confidence intervals, etc., which are available to Pediatric Dentists interested in reading or designing original clinical or epidemiological studies.
7 CFR 1940.331 - Public involvement.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 13 2011-01-01 2009-01-01 true Public involvement. 1940.331 Section 1940.331...) PROGRAM REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940.331 Public involvement. (a) Objective. The basic objective of FmHA or its successor agency under Public Law 103-354's public involvement...
7 CFR 1940.331 - Public involvement.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 13 2010-01-01 2009-01-01 true Public involvement. 1940.331 Section 1940.331...) PROGRAM REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940.331 Public involvement. (a) Objective. The basic objective of FmHA or its successor agency under Public Law 103-354's public involvement...
Evaluation of hyaluronic acid-protein conjugates for polymer masked-unmasked protein therapy.
Ferguson, Elaine L; Alshame, Alshame M J; Thomas, David W
2010-12-15
Bioresponsive polymers may effectively be utilized to enhance the circulation time and stability of biologically active proteins and peptides, while reducing their immunogenicity and toxicity. Recently, dextrin-epidermal growth factor (EGF) conjugates, which make use of the Polymer-masked UnMasked Protein Therapy (PUMPT) concept, have been developed and shown potential as modulators of impaired wound healing. This study investigated the potential of PUMPT using hyaluronic acid (HA) conjugates to mask activity and enhance protein stability, while allowing restoration of biological activity following triggered degradation. HA fragments (Mw ∼90,000g/mol), obtained by acid hydrolysis of Rooster comb HA, were conjugated to trypsin as a model enzyme or to EGF as a model growth factor. Conjugates contained 2.45 and 0.98% (w/w) trypsin or EGF, respectively, and contained <5% free protein. HA conjugation did not significantly alter trypsin's activity. However, incubation of the conjugate with physiological concentrations of HAase increased its activity to ∼145% (p<0.001) that of the free enzyme. In contrast, when HA-EGF conjugates were tested in vitro, no effect on cell proliferation was seen, even in the presence of HAase. HA conjugates did not display typical masking/unmasking behavior, HA-trypsin conjugates exhibited ∼52% greater stability in the presence of elastase, compared to free trypsin, demonstrating the potential of HA conjugates for further development as modulators of tissue repair. Copyright © 2010 Elsevier B.V. All rights reserved.
ERIC Educational Resources Information Center
Chu, Hye-Eun; Treagust, David F.; Chandrasegaran, A. L.
2009-01-01
A large scale study involving 1786 year 7-10 Korean students from three school districts in Seoul was undertaken to evaluate their understanding of basic optics concepts using a two-tier multiple-choice diagnostic instrument consisting of four pairs of items, each of which evaluated the same concept in two different contexts. The instrument, which…
Orthodontics for the dog. Bite evaluation, basic concepts, and equipment.
Ross, D L
1986-09-01
Evaluation of canine occlusion (an occlusal evaluation table is included), growth patterns of the head, basic concepts of orthodontics such as how teeth move, length of treatment, and limits to movements, and equipment and materials are considered in this article.
Chicano Alternative Education.
ERIC Educational Resources Information Center
Galicia, H. Homero; Almaguer, Clementina
Alternative schooling is challenging some basic notions of curriculum, operation, and structure of traditional schools; it is not challenging the basic concept of schooling. Chicano alternative education, an elusive concept, lacks a precise definition. Chicano alternative schools reflect a vast diversity in structure, focus, and goals. The Chicano…
Del Pinal, Guillermo; Reuter, Kevin
2017-04-01
The concepts expressed by social role terms such as artist and scientist are unique in that they seem to allow two independent criteria for categorization, one of which is inherently normative (Knobe, Prasada, & Newman, 2013). This study presents and tests an account of the content and structure of the normative dimension of these "dual character concepts." Experiment 1 suggests that the normative dimension of a social role concept represents the commitment to fulfill the idealized basic function associated with the role. Background information can affect which basic function is associated with each social role. However, Experiment 2 indicates that the normative dimension always represents the relevant commitment as an end in itself. We argue that social role concepts represent the commitments to basic functions because that information is crucial to predict the future social roles and role-dependent behavior of others. Copyright © 2016 Cognitive Science Society, Inc.
ERIC Educational Resources Information Center
Mercer County Community Coll., Trenton, NJ.
Instructional materials are provided for a course that covers basic concepts of physics and chemistry. Designed for use in a workplace literacy project developed by Mercer County Community College (New Jersey) and its partners, the course describes applications of these concepts to real-life situations, with an emphasis on applications of…
Peng, Huan; Luo, Shujie; Huang, Wenkun; Cui, Jiangkuan; Li, Xin; Kong, Lingan; Jiang, Daohong; Chitwood, David J.; Peng, Deliang
2016-01-01
Heterodera avenae and H. filipjevi are major parasites of wheat, reducing production worldwide. Both are sedentary endoparasitic nematodes, and their development and parasitism depend strongly on nutrients obtained from hosts. Secreted fatty acid- and retinol-binding (FAR) proteins are nematode-specific lipid carrier proteins used for nutrient acquisition as well as suppression of plant defenses. In this study, we obtained three novel FAR genes Ha-far-1 (KU877266), Ha-far-2 (KU877267), Hf-far-1 (KU877268). Ha-far-1 and Ha-far-2 were cloned from H. avenae, encoding proteins of 191 and 280 amino acids with molecular masses about 17 and 30 kDa, respectively and sequence identity of 28%. Protein Blast in NCBI revealed that Ha-FAR-1 sequence is 78% similar to the Gp-FAR-1 protein from Globodera pallida, while Ha-FAR-2 is 30% similar to Rs-FAR-1 from Radopholus similis. Only one FAR protein Hf-FAR-1was identified in H. filipjevi; it had 96% sequence identity to Ha-FAR-1. The three proteins are alpha-helix-rich and contain the conserved domain of Gp-FAR-1, but Ha-FAR-2 had a remarkable peptide at the C-terminus which was random-coil-rich. Both Ha-FAR-1 and Hf-FAR-1 had casein kinase II phosphorylation sites, while Ha-FAR-2 had predicted N-glycosylation sites. Phylogenetic analysis showed that the three proteins clustered together, though Ha-FAR-1 and Hf-FAR-1 adjoined each other in a plant-parasitic nematode branch, but Ha-FAR-2 was distinct from the other proteins in the group. Fluorescence-based ligand binding analysis showed the three FAR proteins bound to a fluorescent fatty acid derivative and retinol and with dissociation constants similar to FARs from other species, though Ha-FAR-2 binding ability was weaker than that of the two others. In situ hybridization detected mRNAs of Ha-far-1 and Ha-far-2 in the hypodermis. The qRT-PCR results showed that the Ha-far-1and Ha-far-2 were expressed in all developmental stages; Ha-far-1 expressed 70 times more than Ha-far-2 in all stages. The highest expression level of Ha-far-1 was observed in fourth-stage juvenile (J4), whereas the highest expression level of Ha-far-2 occurred in second-stage juvenile (J2). In conclusion, we have identified two novel far genes from H. avenae and one from H. filipjevi and have provided further indication that nematode far genes are present in a variety of nematode species, where the FAR proteins share similar basic structure, expression pattern and biochemical activities. PMID:27479008
Reassortment between Influenza B Lineages and the Emergence of a Coadapted PB1–PB2–HA Gene Complex
Dudas, Gytis; Bedford, Trevor; Lycett, Samantha; Rambaut, Andrew
2015-01-01
Influenza B viruses make a considerable contribution to morbidity attributed to seasonal influenza. Currently circulating influenza B isolates are known to belong to two antigenically distinct lineages referred to as B/Victoria and B/Yamagata. Frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. We investigate interlineage reassortments by comparing phylogenetic trees across genomic segments. Our analyses indicate that of the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains possess PB1, PB2, and HA segments derived entirely from one or the other lineage; other segments have repeatedly reassorted between lineages thereby reducing genetic diversity. We argue that this difference between segments is due to selection against reassortant viruses with mixed-lineage PB1, PB2, and HA segments. Given sufficient time and continued recruitment to the reassortment-isolated PB1–PB2–HA gene complex, we expect influenza B viruses to eventually undergo sympatric speciation. PMID:25323575
Teaching Individuals with Developmental Delays: Basic Intervention Techniques.
ERIC Educational Resources Information Center
Lovaas, O. Ivar
This teaching manual for treatment of children with developmental disabilities is divided into seven sections that address: (1) basic concepts; (2) transition into treatment; (3) early learning concepts; (4) expressive language; (5) strategies for visual learners; (6) programmatic considerations; and (7) organizational and legal issues. Among…
Environmental Education: Back to Basics.
ERIC Educational Resources Information Center
Warpinski, Robert
1984-01-01
Describes an instructional framework based on concepts of energy, ecosystems, carrying capacity, change, and stewardship. Stresses the importance of determining what is really important (basic) for each student to experience or learn in relation to each concept and grade level. Student-centered learning activities and sample lesson on energy…
Palm, Fredrik; Takahashi, Tomoko; Ikegami-Kawai, Mayumi; Friederich-Persson, Malou; Hansell, Peter
2017-01-01
The content of hyaluronan (HA) in the interstitium of the renal medulla changes in relation to body hydration status. We investigated if hormones of central importance for body fluid homeostasis affect HA production by renomedullary interstitial cells in culture (RMICs). Simultaneous treatment with vasopressin and angiotensin II (Ang II) reduced HA by 69%. No change occurred in the mRNA expressions of hyaluronan synthase 2 (HAS2) or hyaluronidases (Hyals), while Hyal activity in the supernatant increased by 67% and CD44 expression reduced by 42%. The autocoid endothelin (ET-1) at low concentrations (10−10 and 10−8 M) increased HA 3-fold. On the contrary, at a high concentration (10−6 M) ET-1 reduced HA by 47%. The ET-A receptor antagonist BQ123 not only reversed the reducing effect of high ET-1 on HA, but elevated it to the same level as low concentration ET-1, suggesting separate regulating roles for ET-A and ET-B receptors. This was corroborated by the addition of ET-B receptor antagonist BQ788 to low concentration ET-1, which abolished the HA increase. HAS2 and Hyal2 mRNA did not alter, while Hyal1 mRNA was increased at all ET-1 concentrations tested. Hyal activity was elevated the most by high ET-1 concentration, and blockade of ET-A receptors by BQ123 prevented about 30% of this response. The present study demonstrates an important regulatory influence of hormones involved in body fluid balance on HA handling by RMICs, thereby supporting the concept of a dynamic involvement of interstitial HA in renal fluid handling. PMID:29236055
Money Matters for the Young Learner
ERIC Educational Resources Information Center
Hill, Andrew T.
2010-01-01
Children's economic reasoning follows a developmental sequence in which their ideas about money and other basic economic concepts are forming. Even children in the early primary grades can learn some basic economics and retain understanding of economic concepts if they are taught in developmentally appropriate ways. Given how important economic…
ECON 12: Teacher's Materials. Units I and II.
ERIC Educational Resources Information Center
Wiggins, Suzanne
The objectives of this experimental 12th grade economics course begin with an understanding that "economic analysis applies a set of basic concepts and their interrelationships to problems (involving) economic scarcity." Fifteen basic concepts are to be learned (e. g., want, markets, money, etc.) as well as the definition and vocabulary…
Teaching Young Children Basic Concepts of Geography: A Literature-Based Approach.
ERIC Educational Resources Information Center
Hannibal, Mary Anne Zeitler; Vasiliev, Ren; Lin, Qiuyun
2002-01-01
This article advocates a literature-based instructional approach as a way of promoting geographic awareness in early childhood classrooms. Instruction focuses on basic geography concepts of location, place, human- environment interaction, movement, and region. Examples of children's picture books are included to show what early childhood teachers…
Lifeline: A Tool for Logistics Professionals
2017-06-01
proof of concept study is designed to provide a basic understanding of the Supply Corps community, provide a comparative analysis of the organizational...concept study is designed to provide a basic understanding of the Supply Corps community, provide a comparative analysis of the organizational...APPLICATION) ......................................................................................63 G. DESIGN
Basic Concepts and Conservation Skill Training in Kindergarten Chilren.
ERIC Educational Resources Information Center
Wasik, Barbara H.; And Others
1980-01-01
The study investigated the effects of basic concepts training on conservation acquisition in 41 kindergarten children (17 White boys, 15 White girls, 6 Black girls, and 5 Black boys). Only the conservation training program resulted in significant effects, and that was for the White students alone. (Author)
Basic College-Level Pharmacology: Therapeutic Drug Range Lesson Plan.
ERIC Educational Resources Information Center
Laipply, Richelle S.
2000-01-01
Investigations of scientific concepts using inquiry can be included in the traditional college lecture. This lesson uses the Learning Cycle to demonstrate therapeutic drug range, a basic concept in pharmaceutical science. Students use graphing to discover patterns as a part of data analysis and interpretation of provided investigation data.…
Econosense: A Common Sense Approach to the Study of Economics.
ERIC Educational Resources Information Center
McPheron, Linda
This student activity book and teacher's guide address specific economic terms and concepts correlated to specific student learning objectives. The concepts presented are those essential to any student developing a basic understanding of economics. Each lesson follows a specific format with a basic core of information, comprehension questions,…
Basic Concepts of Intercultural Communication: Selected Readings.
ERIC Educational Resources Information Center
Bennett, Milton J., Ed.
This collection of articles, with a developmental learning focus, explores the core building blocks of intercultural communication. The articles in the collection represent the theory-into-practice school of intercultural communication. The collection's goal is to present basic concepts from a variety of perspectives which, when taken together,…
Using a Self-Administered Visual Basic Software Tool To Teach Psychological Concepts.
ERIC Educational Resources Information Center
Strang, Harold R.; Sullivan, Amie K.; Schoeny, Zahrl G.
2002-01-01
Introduces LearningLinks, a Visual Basic software tool that allows teachers to create individualized learning modules that use constructivist and behavioral learning principles. Describes field testing of undergraduates at the University of Virginia that tested a module designed to improve understanding of the psychological concepts of…
Suguitan, Amorsolo L.; Matsuoka, Yumiko; Lau, Yuk-Fai; Santos, Celia P.; Vogel, Leatrice; Cheng, Lily I.; Orandle, Marlene
2012-01-01
Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of their hemagglutinin (HA) protein, a recognized virulence motif in poultry. To determine the importance of the H5 HA MBS as a virulence factor in mammals, recombinant wild-type HPAI A/Vietnam/1203/2004 (H5N1) viruses that possessed (H5N1) or lacked (ΔH5N1) the H5 HA MBS were generated and evaluated for their virulence in BALB/c mice, ferrets, and African green monkeys (AGMs) (Chlorocebus aethiops). The presence of the H5 HA MBS was associated with lethality, significantly higher virus titers in the respiratory tract, virus dissemination to extrapulmonary organs, lymphopenia, significantly elevated levels of proinflammatory cytokines and chemokines, and inflammation in the lungs of mice and ferrets. In AGMs, neither H5N1 nor ΔH5N1 virus was lethal and neither caused clinical symptoms. The H5 HA MBS was associated with mild enhancement of replication and delayed virus clearance. Thus, the contribution of H5 HA MBS to the virulence of the HPAI H5N1 virus varies among mammalian hosts and is most significant in mice and ferrets and less remarkable in nonhuman primates. PMID:22205751
Xia, Yan; Zhou, Panyu; Cheng, Xiaosong; Xie, Yang; Liang, Chong; Li, Chao; Xu, Shuogui
2013-01-01
The regeneration of functional tissue in osseous defects is a formidable challenge in orthopedic surgery. In the present study, a novel biomimetic composite scaffold, here called nano-hydroxyapatite (HA)/poly-ε-caprolactone (PCL) was fabricated using a selective laser sintering technique. The macrostructure, morphology, and mechanical strength of the scaffolds were characterized. Scanning electronic microscopy (SEM) showed that the nano-HA/PCL scaffolds exhibited predesigned, well-ordered macropores and interconnected micropores. The scaffolds have a range of porosity from 78.54% to 70.31%, and a corresponding compressive strength of 1.38 MPa to 3.17 MPa. Human bone marrow stromal cells were seeded onto the nano-HA/PCL or PCL scaffolds and cultured for 28 days in vitro. As indicated by the level of cell attachment and proliferation, the nano-HA/PCL showed excellent biocompatibility, comparable to that of PCL scaffolds. The hydrophilicity, mineralization, alkaline phosphatase activity, and Alizarin Red S staining indicated that the nano-HA/PCL scaffolds are more bioactive than the PCL scaffolds in vitro. Measurements of recombinant human bone morphogenetic protein-2 (rhBMP-2) release kinetics showed that after nano-HA was added, the material increased the rate of rhBMP-2 release. To investigate the in vivo biocompatibility and osteogenesis of the composite scaffolds, both nano-HA/PCL scaffolds and PCL scaffolds were implanted in rabbit femur defects for 3, 6, and 9 weeks. The wounds were studied radiographically and histologically. The in vivo results showed that both nano-HA/PCL composite scaffolds and PCL scaffolds exhibited good biocompatibility. However, the nano-HA/PCL scaffolds enhanced the efficiency of new bone formation more than PCL scaffolds and fulfilled all the basic requirements of bone tissue engineering scaffolds. Thus, they show large potential for use in orthopedic and reconstructive surgery. PMID:24204147
MnO2 Motor: A Prospective Cancer-Starving Therapy Promoter.
Zhang, Yao-Hui; Qiu, Wen-Xiu; Zhang, Mingkang; Zhang, Lu; Zhang, Xian-Zheng
2018-05-02
Here, a tumor-targeted MnO 2 motor nanosystem (designed as MG/HA) was constructed by the assembly of glucose oxidase (GOD), manganese dioxide (MnO 2 ), and glycoprotein CD44-targeting polymer hyaluronic acid (HA) to elevate cancer-starving therapy efficacy in solid tumor. Upon the specific uptake of MG/HA by CD44 overexpressed cancer cells, GOD catalyzed the oxidation of glucose into gluconic acid and hydrogen peroxide (H 2 O 2 ) accompanying the consumption of oxygen (O 2 ). Meanwhile, MnO 2 would react with H 2 O 2 and acid to generate O 2 , which is in turn supplied to the glucose-depletion process, running like a loop. As a result, MnO 2 is displayed as a motor to promote the rate of glucose depletion that contributed to the starving therapy. In contrast to G/HA, MG/HA could not only achieve effective glucose consumption to depress cancer progression, but also alleviate hypoxia and reduce the expression of Glut1 to inhibit the metabolism for further restraining the tumor aggressiveness and metastasis. The concept of MnO 2 motor shows a promising prospect to overcome the restriction of the starving therapy.
Vícha, Jan; Komorovsky, Stanislav; Repisky, Michal; Marek, Radek; Straka, Michal
2018-06-12
The importance of relativistic effects on the NMR parameters in heavy-atom (HA) compounds, particularly the SO-HALA (Spin-Orbit Heavy Atom on the Light Atom) effect on NMR chemical shifts, has been known for about 40 years. Yet, a general correlation between the electronic structure and SO-HALA effect has been missing. By analyzing 1 H NMR chemical shifts of the sixth-period hydrides (Cs-At), we discovered general electronic-structure principles and mechanisms that dictate the size and sign of the SO-HALA NMR chemical shifts. In brief, partially occupied HA valence shells induce relativistic shielding at the light atom (LA) nuclei, while empty HA valence shells induce relativistic deshielding. In particular, the LA nucleus is relativistically shielded in 5d 2 -5d 8 and 6p 4 HA hydrides and deshielded in 4f 0 , 5d 0 , 6s 0 , and 6p 0 HA hydrides. This general and intuitive concept explains periodic trends in the 1 H NMR chemical shifts along the sixth-period hydrides (Cs-At) studied in this work. We present substantial evidence that the introduced principles have a general validity across the periodic table and can be extended to nonhydride LAs. The decades-old question of why compounds with occupied frontier π molecular orbitals (MOs) cause SO-HALA shielding at the LA nuclei, while the frontier σ MOs cause deshielding is answered. We further derive connection between the SO-HALA NMR chemical shifts and Spin-Orbit-induced Electron Deformation Density (SO-EDD), a property that can be obtained easily from differential electron densities and can be represented graphically. SO-EDD provides an intuitive understanding of the SO-HALA effect in terms of the depletion/concentration of the electron density at LA nuclei caused by spin-orbit coupling due to HA in the presence of a magnetic field. Using an analogy between the SO-EDD concept and arguments from classic NMR theory, the complex question of the SO-HALA NMR chemical shifts becomes easily understandable for a wide chemical audience.
Meeting Basic Needs Is Not beyond Our Reach.
ERIC Educational Resources Information Center
Haq, Mahbub ul
1978-01-01
Reviews the status of the continuing debate on the concept of "basic needs" in development policy for the world's poorest countries, reprinted from a World Bank report. Discusses "core" basic needs (food and nutrition, drinking water, basic health, shelter, and basic education) and possible operational policies. (MF)
TAF1, From a General Transcription Factor to Modulator of Androgen Receptor in Prostate Cancer
2009-02-01
TN, Ferguson HA, Galasinski SK, Seto AG, Goodrich JA 2001 c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II... Galasinski SK, Goodrich JA 2004 The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with the N
Three Short Films about Water: Presenting Basic Concepts to Students and Stakeholders
NASA Astrophysics Data System (ADS)
Arrigo, J. S.; Hooper, R. P.; Michel, A.; Wilde, P.; Lilienfeld, L.
2011-12-01
Three short form (3 - 5 minute) movies were produced for CUAHSI, to convey basic concepts such as a hydrologic budget, stores and fluxes of water, and the flowpaths and residence time of water. The films were originally intended to be used by scientists to explain the concepts behind potential environmental observatories, but evolved into serving a broader purpose. The films combine still photos, satellite images, animation and video clips, and interviews with CUAHSI members explaining hydrologic concepts in simple, accessible terms. In producing these films, we have found the importance of engaging scientists in conversation first, to develop a script around key accessible concepts and relevant information. Film and communication professionals play a critical role in distilling the scientific explanation and concepts into accessible, engaging film material. The films have been widely distributed through CD and online to educators for use in courses. Additionally, they provide a way to engage stakeholders, particularly land owners, by conveying basic concepts that are necessary to understand the hydrologic and earth science foundation of many of today's political and environmental issues. The films can be viewed online at the CUAHSI website, which also contains links to other film related resources and programs.
Pre-Service Teachers' Mental Models of Basic Astronomy Concepts
ERIC Educational Resources Information Center
Arslan, A. Saglam; Durikan, U.
2016-01-01
The aim of the present study is to determine pre-service teachers' mental models related to basic astronomy concepts. The study was conducted using a survey method with 293 pre-service teachers from 4 different departments; physics education, science education, primary teacher education and early childhood education. An achievement test with…
Item Response Theory: A Basic Concept
ERIC Educational Resources Information Center
Mahmud, Jumailiyah
2017-01-01
With the development in computing technology, item response theory (IRT) develops rapidly, and has become a user friendly application in psychometrics world. Limitation in classical theory is one aspect that encourages the use of IRT. In this study, the basic concept of IRT will be discussed. In addition, it will briefly review the ability…
Pima College Students' Knowledge of Selected Basic Physical Science Concepts.
ERIC Educational Resources Information Center
Iadevaia, David G.
In 1989 a study was conducted at Pima Community College (PCC) to assess students' knowledge of basic physical science concepts. A three-part survey instrument was administered to students in a second semester sociology class, a first semester astronomy class, a second semester Spanish class, and a first semester physics class. The survey…
Spanish Translation and Validation of the Bracken Basic Concept Scale.
ERIC Educational Resources Information Center
Bracken, Bruce A; Fouad, Nadya
1987-01-01
The Bracken Basic Concept Scale (BBCS) was translated into Spanish, and 32 preschool and primary age bilingual children were assessed in a counter-balanced format with the English and newly translated Spanish forms to assess the adequacy of the translation. Preliminary content validity of the Spanish BBCS was demonstrated. (Author/JAZ)
Multinational Validation of the Spanish Bracken Basic Concept Scale for Cross-Cultural Assessments.
ERIC Educational Resources Information Center
Bracken, Bruce A.; And Others
1990-01-01
Investigated construct validity of the Spanish translation of the Bracken Basic Concept Scale (BBCS) in Latino children (n=293) including monolingual Spanish-speaking children from Puerto Rico and Venezuela and Spanish-dominant bilingual Latino children from Texas. Results provided support for construct validity of the Spanish version of the…
ERIC Educational Resources Information Center
South Dakota Dept. of Environmental Protection, Pierre.
Presented are basic concepts of chemistry necessary for operators who manage drinking water treatment plants and wastewater facilities. It includes discussions of chemical terms and concepts, laboratory procedures for basic analyses of interest to operators, and discussions of appropriate chemical calculations. Exercises are included and answer…
Introduction to Probability, Part 1 - Basic Concepts. Student Text. Revised Edition.
ERIC Educational Resources Information Center
Blakeslee, David W.; And Others
This book is designed to introduce the reader to some fundamental ideas about probability. The mathematical theory of probability plays an increasingly important role in science, government, industry, business, and economics. An understanding of the basic concepts of probability is essential for the study of statistical methods that are widely…
Getting Back to Basics (& Acidics)
ERIC Educational Resources Information Center
Rhodes, Sam
2006-01-01
This article describes a few novel acid-base experiments intended to introduce students to the basic concepts of acid-base chemistry and provide practical examples that apply directly to the study of biology and the human body. Important concepts such as the reaction between carbon dioxide and water, buffers and protein denaturation, are covered.…
Teacher knowledge of basic language concepts and dyslexia.
Washburn, Erin K; Joshi, R Malatesha; Binks-Cantrell, Emily S
2011-05-01
Roughly one-fifth of the US population displays one or more symptoms of dyslexia: a specific learning disability that affects an individual's ability to process written language. Consequently, elementary school teachers are teaching students who struggle with inaccurate or slow reading, poor spelling, poor writing, and other language processing difficulties. Findings from studies have indicated that teachers lack essential knowledge needed to teach struggling readers, particularly children with dyslexia. However, few studies have sought to assess teachers' knowledge and perceptions about dyslexia in conjunction with knowledge of basic language concepts related to reading instruction. Thus, the purpose of the present study was to examine elementary school teachers' knowledge of basic language concepts and their knowledge and perceptions about dyslexia. Findings from the present study indicated that teachers, on average, were able to display implicit skills related to certain basic language concepts (i.e. syllable counting), but failed to demonstrate explicit knowledge of others (i.e. phonics principles). Also, teachers seemed to hold the common misconception that dyslexia is a visual processing deficit rather than phonological processing deficit. Copyright © 2011 John Wiley & Sons, Ltd.
Maximum Likelihood Estimation with Emphasis on Aircraft Flight Data
NASA Technical Reports Server (NTRS)
Iliff, K. W.; Maine, R. E.
1985-01-01
Accurate modeling of flexible space structures is an important field that is currently under investigation. Parameter estimation, using methods such as maximum likelihood, is one of the ways that the model can be improved. The maximum likelihood estimator has been used to extract stability and control derivatives from flight data for many years. Most of the literature on aircraft estimation concentrates on new developments and applications, assuming familiarity with basic estimation concepts. Some of these basic concepts are presented. The maximum likelihood estimator and the aircraft equations of motion that the estimator uses are briefly discussed. The basic concepts of minimization and estimation are examined for a simple computed aircraft example. The cost functions that are to be minimized during estimation are defined and discussed. Graphic representations of the cost functions are given to help illustrate the minimization process. Finally, the basic concepts are generalized, and estimation from flight data is discussed. Specific examples of estimation of structural dynamics are included. Some of the major conclusions for the computed example are also developed for the analysis of flight data.
Clinical caring science as a scientific discipline.
Rehnsfeldt, Arne; Arman, Maria; Lindström, Unni Å
2017-09-01
Clinical caring science will be described from a theory of science perspective. The aim of this theoretical article to give a comprehensive overview of clinical caring science as a human science-based discipline grounded in a theory of science argumentation. Clinical caring science seeks idiographic or specific variations of the ontology, concepts and theories, formulated by caring science. The rationale is the insight that the research questions do not change when they are addressed in different contexts. The academic subject contains a concept order with ethos concepts, core and basic concepts and practice concepts that unites systematic caring science with clinical caring science. In accordance with a hermeneutic tradition, the idea of the caring act is based on the degree to which the theory base is hermeneutically appropriated by the caregiver. The better the ethos, essential concepts and theories are understood, the better the caring act can be understood. In order to understand the concept order related to clinical caring science, an example is given from an ongoing project in a disaster context. The concept order is an appropriate way of making sense of the essence of clinical caring science. The idea of the concept order is that concepts on all levels need to be united with each other. A research project in clinical caring science can start anywhere on the concept order, either in ethos, core concepts, basic concepts, practice concepts or in concrete clinical phenomena, as long as no parts are locked out of the concept order as an entity. If, for example, research on patient participation as a phenomenon is not related to core and basic concepts, there is a risqué that the research becomes meaningless. © 2016 Nordic College of Caring Science.
Adamiano, Alessio; Iafisco, Michele; Sandri, Monica; Basini, Martina; Arosio, Paolo; Canu, Tamara; Sitia, Giovanni; Esposito, Antonio; Iannotti, Vincenzo; Ausanio, Giovanni; Fragogeorgi, Eirini; Rouchota, Maritina; Loudos, George; Lascialfari, Alessandro; Tampieri, Anna
2018-06-01
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner. FeHA applied a higher contrast enhancement, and had a longer endurance in the liver with respect to Endorem® at iron equality. Additionally, a proof of concept of FeHA use as scintigraphy imaging agent for positron emission tomography (PET) and single photon emission computed tomography (SPECT) was given labeling FeHA with 99m Tc-MDP by a straightforward surface functionalization process. Scintigraphy/x-ray fused imaging and ex vivo studies confirmed its dominant accumulation in the liver, and secondarily in other organs of the mononuclear phagocyte system. FeHA efficiency as MRI-T 2 and PET-SPECT imaging agent combined to its already reported intrinsic biocompatibility qualifies it as a promising material for innovative nanomedical applications. The ability of iron-doped hydroxyapatite nanoaprticles (FeHA) to work in vivo as imaging agents for magnetic resonance (MR) and nuclear imaging is demonstrated. FeHA applied an higher MR contrast in the liver, spleen and kidneys of mice with respect to Endorem®. The successful radiolabeling of FeHA allowed for scintigraphy/X-ray and ex vivo biodistribution studies, confirming MR results and envisioning FeHA application for dual-imaging. Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Wedde, Marianne; Biere, Barbara; Wolff, Thorsten; Schweiger, Brunhilde
2015-10-01
This report describes the evolution of the influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in Germany between 2008-2009 and 2013-2014. The phylogenetic analysis of the hemagglutinin (HA) genes of both subtypes revealed similar evolution of the HA variants that were also seen worldwide with minor exceptions. The analysis showed seven distinct HA clades for A(H1N1)pdm09 and six HA clades for A(H3N2) viruses. Herald strains of both subtypes appeared sporadically since 2008-2009. Regarding A(H1N1)pdm09, herald strains of HA clade 3 and 4 were detected late in the 2009-2010 season. With respect to A(H3N2), we found herald strains of HA clade 3, 4 and 7 between 2009 and 2012. Those herald strains were predominantly seen for minor and not for major HA clades. Generally, amino acid substitutions were most frequently found in the globular domain, including substitutions near the antigenic sites or the receptor binding site. Differences between both influenza A subtypes were seen with respect to the position of the indicated substitutions in the HA. For A(H1N1)pdm09 viruses, we found more substitutions in the stem region than in the antigenic sites. In contrast, in A(H3N2) viruses most changes were identified in the major antigenic sites and five changes of potential glycosylation sites were identified in the head of the HA monomer. Interestingly, we found in seasons with less influenza activity a relatively high increase of substitutions in the head of the HA in both subtypes. This might be explained by the fact that mutations under negative selection are subsequently compensated by secondary mutations to restore important functions e.g. receptor binding properties. A better knowledge of basic evolution strategies of influenza viruses will contribute to the refinement of predictive mathematical models for identifying novel antigenic drift variants. Copyright © 2015 Elsevier GmbH. All rights reserved.
[Prior health advice to immigrants who travel to visit family and friends].
Roca, Carme; Aguilar, Anna; Valerio, Lluís; Solsona, Lluís; Carrasco, Clara; Gimeno-Feliu, Luis Andrés
2014-04-01
Immigrants who make or plan journeys to visit their families in their countries of origin (immigrants -visiting friends and relatives, I-VFR) have a higher risk of acquiring travel-associated diseases than other travellers. The main aim of this study is to analyse the knowledge of the immigrant population on the need to receive health advice (HA) before making international journeys in general and in particular before travelling to their country of origin. Observational, multicentre study. Ten Family Doctors from 10 Health Centres in Catalonia and Aragon participated A total of 555 immigrants ≥ 15 years of age, who consulted their Family Doctor and agreed to answer a questionnaire. Opportunity sampling was used. A total of 389 (70.1%) of those surveyed considered it necessary to receive HA before making an international journey, 406 (73.2%) were I-VFR and 145 (35.7%) had requested HA prior to the journey, mostly from their Family Doctor (n=60; 41.1%). Almost two-thirds (261, 65.2%) of the subjects did not seek HA, with the most common reason being that they did not consider it necessary (173, 42.6%). I-VFR do not usually request HA prior to travelling, basic due to considering it unnecessary. When they do request it, they are very often initially directed to their Family Doctor. Copyright © 2013 Elsevier España, S.L. All rights reserved.
Marques, J Frederico
2007-12-01
The deterioration of semantic memory usually proceeds from more specific to more general superordinate categories, although rarer cases of superordinate knowledge impairment have also been reported. The nature of superordinate knowledge and the explanation of these two semantic impairments were evaluated from the analysis of superordinate and basic-level feature norms. The results show that, in comparison to basic-level concepts, superordinate concepts are not generally less informative and have similar feature distinctiveness and proportion of individual sensory features, but their features are less shared by their members. Results are in accord with explanations based on feature connection weights and/or concept confusability for the superordinate advantage cases. Results especially support an explanation for superordinate impairments in terms of higher semantic control requirements as related to features being less shared between concept members. Implications for patients with semantic impairments are also discussed.
Concept confusion and concept discernment in basic magnetism using analogical reasoning
NASA Astrophysics Data System (ADS)
Lemmer, Miriam; Nicodimus Morabe, Olebogeng
2017-07-01
Analogical reasoning is central to all learning, whether in daily life situations, in the classroom or while doing research. Although analogies can aid the learning process of making sense of phenomena and understanding new ideas in terms of known ideas, these should be used with care. This article reports a study of the use of analogies and the consequences of this use in the teaching of magnetism with special reference to misconceptions. We begin by identifying concept confusion and associated misconceptions in magnetism due to in-service physics teachers’ spontaneous analogical reasoning. Two analogy-based experiments that can be used to convert such concept confusion to discernment are then described. These experiments focus on understanding basic principles about sources and interactions of magnetic fields and implement the constructivist learning processes of discrimination and generalization. Lastly, recommendations towards reinforcement of conceptual understanding of basic magnetism in its relation to electricity are proposed.
Full-Genome Sequence of a Reassortant H1N2 Influenza A Virus Isolated from Pigs in Brazil.
Schmidt, Candice; Cibulski, Samuel Paulo; Muterle Varela, Ana Paula; Mengue Scheffer, Camila; Wendlant, Adrieli; Quoos Mayer, Fabiana; Lopes de Almeida, Laura; Franco, Ana Cláudia; Roehe, Paulo Michel
2014-12-18
In this study, the full-genome sequence of a reassortant H1N2 swine influenza virus is reported. The isolate has the hemagglutinin (HA) and neuraminidase (NA) genes from human lineage (H1-δ cluster and N2), and the internal genes (polymerase basic 1 [PB1], polymerase basic 2 [PB2], polymerase acidic [PA], nucleoprotein [NP], matrix [M], and nonstructural [NS]) are derived from human 2009 pandemic H1N1 (H1N1pdm09) virus. Copyright © 2014 Schmidt et al.
Effects of Concept Mapping Instruction Approach on Students' Achievement in Basic Science
ERIC Educational Resources Information Center
Ogonnaya, Ukpai Patricia; Okafor, Gabriel; Abonyi, Okechukwu S.; Ugama, J. O.
2016-01-01
The study investigated the effects of concept mapping on students' achievement in basic science. The study was carried out in Ebonyi State of Nigeria. The study employed a quasi-experimental design. Specifically the pretest posttest non-equivalent control group research design was used. The sample was 122 students selected from two secondary…
A Short Test for the Assessment of Basic Knowledge in Psychology
ERIC Educational Resources Information Center
Peter, Johannes; Leichner, Nikolas; Mayer, Anne-Kathrin; Krampen, Günter
2015-01-01
This paper reports the development of a fixed-choice test for the assessment of basic knowledge in psychology, for use with undergraduate as well as graduate students. Test content is selected based on a core concepts approach and includes a sample of concepts which are indexed most frequently in common introductory psychology textbooks. In a…
Raising native plants in nurseries: basic concepts
R. Kasten Dumroese; Thomas D. Landis; Tara Luna
2012-01-01
Growing native plants can be fun, challenging, and rewarding. This booklet, particularly the first chapter that introduces important concepts, is for the novice who wants to start growing native plants as a hobby; however, it can also be helpful to someone with a bit more experience who is wondering about starting a nursery. The second chapter provides basic...
Geographies of American Popular Music: Introducing Students to Basic Geographic Concepts
ERIC Educational Resources Information Center
McClain, Stephen S.
2010-01-01
Popular music can be used to study many subjects and issues related to the social sciences. "Geographies of American Popular Music" was a workshop that not only examined the history and development of select genres of American music, it also introduced students to basic geographic concepts such as the culture hearth and spatial diffusion. Through…
A Framework for Teaching Basic Economic Concepts with Scope and Sequence Guidelines K-12.
ERIC Educational Resources Information Center
Saunders, Phillip, Ed.; Gilliard, June V., Ed.
This publication is an updated, edited merger of two earlier National Council on Economic Education documents: "A Framework for Teaching the Basic Concepts" and "Economics: What and When." The combined publication is designed to aid those who construct curricula or who provide economics instruction in U.S. schools. The book…
The Vital Role of Basic Mathematics in Teaching and Learning the Mole Concept
ERIC Educational Resources Information Center
Mehrotra, Alka; Koul, Anjni
2016-01-01
This article focuses on the importance of activity-based teaching in understanding the mole concept and the vital role of basic mathematical operations. It describes needs-based training for teachers in a professional development programme in India. Analysis of test results before and after the training indicates that teachers improved their…
Master Curriculum Guide in Economics. A Framework for Teaching the Basic Concepts. Second Edition.
ERIC Educational Resources Information Center
Saunders, Phillip; And Others
Intended for curriculum developers, this revised Framework presents a set of basic concepts for teaching K-12 economics. The revision reflects the change and development which the field of economics has undergone and includes improvements suggested by users of the first edition. The purpose of teaching economics is to impart a general…
ERIC Educational Resources Information Center
Bockman, David Carl
The purpose of this study was to compare the conventional lecture-discussion method and an illustrated programed textbook method when teaching a unit of instruction on the basic concepts of metallurgy. The control group used a portion of a conventional textbook accompanied by lecture, chalkboard illustration, and class discussion. The experimental…
Spatial Thinking Concepts in Early Grade-Level Geography Standards
ERIC Educational Resources Information Center
Anthamatten, Peter
2010-01-01
Research in the cognition and learning sciences has demonstrated that the human brain contains basic structures whose functions are to perform a variety of specific spatial reasoning tasks and that children are capable of learning basic spatial concepts at an early age. There has been a call from within geography to recognize research on spatial…
Love, Power, and Conflict: A Systems Model of Interparty Negotiation.
ERIC Educational Resources Information Center
Slawski, Carl
Some basic hypotheses and corresponding definitions of concepts are presented in an effort to succinctly state the relationship between three of the most basic concepts of social science, namely love, power and conflict. This novel theory is an example of limited reduction. However, it is cast so as to be applicable to both micro and macro levels…
After Almost Half-Century Landing on the Moon and Still Countering Basic Astronomy Conceptions
ERIC Educational Resources Information Center
Türkmen, Hakan
2015-01-01
The purpose of study is to investigate the fifth graders' understandings of the basic astronomy concept and, if they have, to define their misconceptions and then to determine what reason/s behind them. For this purpose, two hundred seventy fifth grade students from 6 different schools participated. Randomly selected 45 students performing under…
The Etymology of Basic Concepts in the Experimental Analysis of Behavior
ERIC Educational Resources Information Center
Dinsmoor, James A.
2004-01-01
The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his…
ERIC Educational Resources Information Center
Adeleke, Ayobami Gideon
2017-01-01
This research paper specifically examined the impact of Geographic Information System (GIS) integration in a learning method and on the performance and retention of Environmental Education (EE) concepts in basic social studies. Non-equivalent experimental research design was employed. 126 pupils in four intact, computer-mediated classrooms were…
NASA Astrophysics Data System (ADS)
Jannati, E. D.; Setiawan, A.; Siahaan, P.; Rochman, C.
2018-05-01
This study aims to determine the description of virtual laboratory learning media development to improve science literacy skills of Mechanical Engineering students on the concept of basic Physics. Quasi experimental method was employed in this research. The participants of this research were first semester students of mechanical engineering in Majalengka University. The research instrument was readability test of instructional media. The results of virtual laboratory learning media readability test show that the average score is 78.5%. It indicates that virtual laboratory learning media development are feasible to be used in improving science literacy skill of Mechanical Engineering students in Majalengka University, specifically on basic Physics concepts of material measurement.
Luben D. Dimov; Jim L. Chambers; Brian Roy Lockhart
2005-01-01
Sustainable forest management and conservation require understanding of underlying basic structural and competitive relationships. To gain insight into these relationships, we analyzed spatial continuity of tree basal area (BA) and crown projection area (CPA) on twelve 0.64-ha plots in four mixed bottomland hardwood stands in Louisiana, Arkansas, and Mississippi....
Zhu, Weimin; Guo, Daiqi; Peng, Liangquan; Chen, Yun Fang; Cui, Jiaming; Xiong, Jianyi; Lu, Wei; Duan, Li; Chen, Kang; Zeng, Yanjun; Wang, Daping
2017-02-01
Objective To assess the effect of the fusion of rabbit bone marrow stromal cells (rBMSCs) and Nano-hydroxyapatite/poly (l-lactic acid) (Nano-HA/PLLA) in repairing the rabbit knee joint with full-thickness cartilage defect. Method The rBMSCs were isolated and cultured in vitro, and the third generation of rBMSCs was co-cultured with the Nano-HA/PLLA to construct the tissue-engineered cartilage (TEC). Eighteen New Zealand white rabbits were selected and randomly divided into three groups, namely, TEC group, Nano-HA/PLLA group, and control group. A cartilage defect model with the diameter of 4.5 mm and depth of 5 mm was constructed on the articular surface of medial malleolus of rabbit femur. General observation, histological observation, and Wakitani's histological scoring were conducted in the 12th and 24th week postoperatively. Results The results of TEC group indicated that new cartilage tissue was formed on the defect site and subchondral bone achieved physiological integration basically. Histological and immunohistochemical analyses indicated the generation of massive extracellular matrix. In contrast, limited regeneration and reconstruction of cartilage was achieved in the Nano-HA/PLLA group and control group, with a significant difference from the TEC group (p < 0.05). Moreover, the effect of cartilage repair was positively correlated with time. Conclusion The porous Nano-HA/PLLA combined with BMSCs promoted the repair of weight-bearing bone of adult rabbit's knee joint with cartilage defect.
Neuroprotection and lifespan extension in Ppt1−/− mice by NtBuHA: therapeutic implications for INCL
Sarkar, Chinmoy; Chandra, Goutam; Peng, Shyiong; Zhang, Zhongjian; Liu, Aiyi; Mukherjee, Anil B.
2013-01-01
Infantile neuronal ceroid lipofuscinosis (INCL) is a devastating childhood neurodegenerative lysosomal storage disease (LSD) that has no effective treatment. It is caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. PPT1-deficiency impairs the cleavage of thioester linkage in palmitoylated proteins (constituents of ceroid), preventing degradation by lysosomal hydrolases. Consequently, accumulation of lysosomal ceroid leads to INCL. Thioester linkage is cleaved by nucleophilic attack. Hydroxylamine, a potent nucleophilic cellular metabolite, may have therapeutic potential for INCL but its toxicity precludes clinical application. Here we report that a hydroxylamine-derivative, N-(tert-Butyl) hydroxylamine (NtBuHA), is non-toxic, cleaves thioester linkage in palmitoylated proteins and mediates lysosomal ceroid depletion in cultured cells from INCL patients. Importantly, in Ppt1−/− mice, which mimic INCL, NtBuHA crossed the blood-brain-barrier, depleted lysosomal ceroid, suppressed neuronal apoptosis, slowed neurological deterioration and extended lifespan. Our findings provide the proof of concept that thioesterase-mimetic and antioxidant small molecules like NtBuHA are potential drug-targets for thioesterase deficiency diseases like INCL. PMID:24056696
NASA Astrophysics Data System (ADS)
Martínez Sebastià, Bernat
2004-12-01
This work is an extened summary of the autor's PhD thesis. It deals with the teaching of astronomy (day/night, seasons) in primary school. At first, students teachers' undestanding of astronomical concepts related to Sun-Earth system have been analysed. Taking into account the results of the previous analysis and using a socio-constructivist approach a teaching sequence has been designed. This sequence has been tested with different groups of students teachers showing an improvement in their undestanding of elementary astronomical concepts. El trabajo que presentamos es un resumen extenso de la tesis doctoral del autor. El enfoque utilizado ha sido tratar de ligar la investigación sobre las ideas, razonamientos y obstáculos de los profesores de primaria con la planificación de la enseñanza del modelo Sol-Tierra que permite explicar el ciclo día/noche y las estaciones. En primer lugar, se ha procedido a realizar un análisis crítico de los resultados que se obtienen en el aprendizaje de los contenidos astronómicos en la enseñanza habitual. En segundo lugar se ha diseñado un curriculum potencialmente superador de esta situación desde una orientación que concibe la enseñanza y el aprendizaje como un proceso de construcción de conocimientos en una estructura problematizada. Finalmente, esta secuencia didáctica ha sido experimentada con diferentes grupos de estudiantes de magisterio, mostrando una mejora relevante en la comprensión de los conceptos astronómicos fundamentales.
Homegardens as a multi-functional land-use strategy in Sri Lanka with focus on carbon sequestration.
Mattsson, Eskil; Ostwald, Madelene; Nissanka, S P; Marambe, Buddhi
2013-11-01
This paper explores the concept of homegardens and their potential functions as strategic elements in land-use planning, and adaptation and mitigation to climate change in Sri Lanka. The ancient and locally adapted agroforestry system of homegardens is presently estimated to occupy nearly 15 % of the land area in Sri Lanka and is described in the scientific literature to offer several ecosystem services to its users; such as climate regulation, protection against natural hazards, enhanced land productivity and biological diversity, increased crop diversity and food security for rural poor and hence reduced vulnerability to climate change. Our results, based on a limited sample size, indicate that the homegardens also store significant amount of carbon, with above ground biomass carbon stocks in dry zone homegardens (n = 8) ranging from 10 to 55 megagrams of carbon per hectare (Mg C ha(-1)) with a mean value of 35 Mg C ha(-1), whereas carbon stocks in wet zone homegardens (n = 4) range from 48 to 145 Mg C ha(-1) with a mean value of 87 Mg C ha(-1). This implies that homegardens may contain a significant fraction of the total above ground biomass carbon stock in the terrestrial system in Sri Lanka, and from our estimates its share has increased from almost one-sixth in 1992 to nearly one-fifth in 2010. In the light of current discussions on reducing emissions from deforestation and forest degradation (REDD+), the concept of homegardens in Sri Lanka provides interesting aspects to the debate and future research in terms of forest definitions, setting reference levels, and general sustainability.
Van Soom, Carolien; Donche, Vincent
2014-01-01
The low success rate of first-year college students in Science, Technology, Engineering, and Mathematics (STEM) programs has spurred many academic achievement studies in which explanatory factors are studied. In this study, we investigated from a person-oriented perspective whether different motivational and academic self-concept profiles could be discerned between male and female first-year college students in STEM and whether differences in early academic achievement were associated with these student groups. Data on autonomous motivation, academic self-concept, and early academic achievement of 1,400 first-year STEM college students were collected. Cluster analyses were used to distinguish motivational profiles based on the relative levels of autonomous motivation and academic self-concept for male and female students. Differences in early academic achievement of the various profiles were studied by means of ANCOVA. Four different motivational profiles were discerned based on the dimensions of autonomous motivation (A) and academic self-concept (S): students scoring high and respectively low on both dimensions (HA-HS or LA-LS), and students scoring high on one dimension and low on the other (HA-LS or LA-HS). Also gender differences were found in this study: male students with high levels of academic self-concept and autonomous motivation had higher academic achievement compared to male students with low levels on both motivational dimensions. For female students, motivational profiles were not associated with academic achievement. The findings partially confirm the internal and external validity of the motivational theories underpinning this study and extend the present insights on identifying subgroup(s) of at risk students in contemporary STEM programs at university level.
Van Soom, Carolien; Donche, Vincent
2014-01-01
The low success rate of first-year college students in Science, Technology, Engineering, and Mathematics (STEM) programs has spurred many academic achievement studies in which explanatory factors are studied. In this study, we investigated from a person-oriented perspective whether different motivational and academic self-concept profiles could be discerned between male and female first-year college students in STEM and whether differences in early academic achievement were associated with these student groups. Data on autonomous motivation, academic self-concept, and early academic achievement of 1,400 first-year STEM college students were collected. Cluster analyses were used to distinguish motivational profiles based on the relative levels of autonomous motivation and academic self-concept for male and female students. Differences in early academic achievement of the various profiles were studied by means of ANCOVA. Four different motivational profiles were discerned based on the dimensions of autonomous motivation (A) and academic self-concept (S): students scoring high and respectively low on both dimensions (HA-HS or LA-LS), and students scoring high on one dimension and low on the other (HA-LS or LA-HS). Also gender differences were found in this study: male students with high levels of academic self-concept and autonomous motivation had higher academic achievement compared to male students with low levels on both motivational dimensions. For female students, motivational profiles were not associated with academic achievement. The findings partially confirm the internal and external validity of the motivational theories underpinning this study and extend the present insights on identifying subgroup(s) of at risk students in contemporary STEM programs at university level. PMID:25390942
Health, vital goals, and central human capabilities.
Venkatapuram, Sridhar
2013-06-01
I argue for a conception of health as a person's ability to achieve or exercise a cluster of basic human activities. These basic activities are in turn specified through free-standing ethical reasoning about what constitutes a minimal conception of a human life with equal human dignity in the modern world. I arrive at this conception of health by closely following and modifying Lennart Nordenfelt's theory of health which presents health as the ability to achieve vital goals. Despite its strengths I transform Nordenfelt's argument in order to overcome three significant drawbacks. Nordenfelt makes vital goals relative to each community or context and significantly reflective of personal preferences. By doing so, Nordenfelt's conception of health faces problems with both socially relative concepts of health and subjectively defined wellbeing. Moreover, Nordenfelt does not ever explicitly specify a set of vital goals. The theory of health advanced here replaces Nordenfelt's (seemingly) empty set of preferences and society-relative vital goals with a human species-wide conception of basic vital goals, or 'central human capabilities and functionings'. These central human capabilities come out of the capabilities approach (CA) now familiar in political philosophy and economics, and particularly reflect the work of Martha Nussbaum. As a result, the health of an individual should be understood as the ability to achieve a basic cluster of beings and doings-or having the overarching capability, a meta-capability, to achieve a set of central or vital inter-related capabilities and functionings. © 2012 John Wiley & Sons Ltd.
HEALTH, VITAL GOALS, AND CENTRAL HUMAN CAPABILITIES
Venkatapuram, Sridhar
2013-01-01
I argue for a conception of health as a person's ability to achieve or exercise a cluster of basic human activities. These basic activities are in turn specified through free-standing ethical reasoning about what constitutes a minimal conception of a human life with equal human dignity in the modern world. I arrive at this conception of health by closely following and modifying Lennart Nordenfelt's theory of health which presents health as the ability to achieve vital goals. Despite its strengths I transform Nordenfelt's argument in order to overcome three significant drawbacks. Nordenfelt makes vital goals relative to each community or context and significantly reflective of personal preferences. By doing so, Nordenfelt's conception of health faces problems with both socially relative concepts of health and subjectively defined wellbeing. Moreover, Nordenfelt does not ever explicitly specify a set of vital goals. The theory of health advanced here replaces Nordenfelt's (seemingly) empty set of preferences and society-relative vital goals with a human species-wide conception of basic vital goals, or ‘central human capabilities and functionings’. These central human capabilities come out of the capabilities approach (CA) now familiar in political philosophy and economics, and particularly reflect the work of Martha Nussbaum. As a result, the health of an individual should be understood as the ability to achieve a basic cluster of beings and doings—or having the overarching capability, a meta-capability, to achieve a set of central or vital inter-related capabilities and functionings. PMID:22420910
ERIC Educational Resources Information Center
Blonder, Ron; Sakhnini, Sohair
2012-01-01
A nanotechnology module was developed for ninth grade students in the context of teaching chemistry. Two basic concepts in nanotechnology were chosen: (1) size and scale and (2) surface-area-to-volume ratio (SA/V). A wide spectrum of instructional methods (e.g., game-based learning, learning with multimedia, learning with models, project based…
ERIC Educational Resources Information Center
Sim, Joong Hiong; Daniel, Esther Gnanamalar Sarojini
2014-01-01
Representational competence is defined as "skills in interpreting and using representations". This study attempted to compare students' of high, medium, and low levels of understanding of (1) basic chemical concepts, and (2) chemical representations, in their representational competence. A total of 411 Form 4 science students (mean age =…
ERIC Educational Resources Information Center
Codding, Robin S.; Mercer, Sterett; Connell, James; Fiorello, Catherine; Kleinert, Whitney
2016-01-01
There is a paucity of evidence supporting the use of curriculum-based mathematics measures (M-CBMs) at the middle school level, which makes data-based decisions challenging for school professionals. The purpose of this study was to examine the relationships among three existing M-CBM indices: (a) basic facts, (b) concepts/application, and (c)…
Inservice Elementary and Middle School Teachers' Conceptions of Photosynthesis and Respiration
ERIC Educational Resources Information Center
Krall, Rebecca McNall; Lott, Kimberly H.; Wymer, Carol L.
2009-01-01
The purpose of this descriptive study was to investigate inservice elementary and middle school teachers' conceptions of photosynthesis and respiration, basic concepts they are expected to teach. A forced-choice instrument assessing selected standards-based life science concepts with non-scientific conceptions embedded in distracter options was…
Architecture is Elementary: Visual Thinking through Architectural Concepts.
ERIC Educational Resources Information Center
Winters, Nathan B.
This book presents very basic but important concepts about architecture and outlines some of the most important concepts used by great architects. These concepts are taught at levels of perceptual maturity applicable to adults and children alike and progress from levels one through seven as the concepts become progressively intertwined. The…
Nebulized hyaluronan ameliorates lung inflammation in cystic fibrosis mice.
Gavina, Manuela; Luciani, Alessandro; Villella, Valeria R; Esposito, Speranza; Ferrari, Eleonora; Bressani, Ilaria; Casale, Alida; Bruscia, Emanuela M; Maiuri, Luigi; Raia, Valeria
2013-08-01
Chronic lung inflammation with increased susceptibility to bacterial infections cause much of the morbidity and mortality in patients with cystic fibrosis (CF), the most common severe, autosomal recessively inherited disease in the Caucasian population. Exogenous inhaled hyaluronan (HA) can exert a protective effect against injury and beneficial effects of HA have been shown in experimental models of chronic respiratory diseases. Our objective was to examine whether exogenous administration of nebulized HA might interfere with lung inflammation in CF. F508del homozygous mice (Cftr(F508del) ) and transgenic mice overexpressing the ENaC channel β-subunit (Scnn1b-Tg) were treated with nebulized HA (0.5 mg/mouse/day for 7 days). Tumor necrosis factor-alpha (TNFα), macrophage inflammatory protein-2 (MIP-2), myeloperoxidase (MPO) levels, and macrophage infiltration were assessed on lung tissues. IB3-1 and CFBE41o-epithelial cell lines were cultured with HA (24 hr, 100 µg/ml) and Reactive Oxygen Species (ROS), Tissue Transglutaminase (TG2) SUMOylation and Peroxisome Proliferator Activated Receptor gamma (PPARγ) and phospho-p42/p44 levels were measured by dichlorodihydrofluorescein assay, or fluorescence resonance energy transfer (FRET) microscopy or immunoblots. Nebulized HA reduced TNFα expression (P < 0.005); TNFα, MIP-2, and MPO protein levels (P < 0.05); MPO activity (P < 0.05); and CD68+ cells counts (P < 0.005) in lung tissues of Cftr(F508del) and Scnn1b-Tg mice, compared with saline-treated mice. HA reduced ROS, TG2 SUMOylation, TG2 activity, phospho-p42-44, and increased PPARγ protein in both IB3-1 and CFBE41o cells (P < 0.05). Nebulized HA is effective in controlling inflammation in vivo in mice CF airways and in vitro in human airway epithelial cells. We provide the proof of concept for the use of inhaled HA as a potential anti-inflammatory drug in CF therapy. Copyright © 2012 Wiley Periodicals, Inc.
Aging, physical activity, and cognitive processing: an examination of P300.
McDowell, K; Kerick, S E; Santa Maria, D L; Hatfield, B D
2003-01-01
Physical activity appears to attenuate the decline of cognitive function typically observed in older men and women. The P300 component of the event-related potential (ERP) is particularly affected by aging and allows for basic neurobiological assessment of cognitive function. Three aspects of the P300 component (i.e. latency, amplitude, and area under the curve (AUC)), elicited by an oddball task, were derived to assess cognitive function in young and older participants (N=73) who were further classified as high- and low-active. The low-active elderly participants exhibited larger AUC values than those observed in all other groups which were undifferentiated. That is, the high-active elderly and the young participants exhibited smaller AUC values than the low-active older group. In conclusion, higher levels of physical activity in the elderly may be associated with a reduction in the neural resources allocated in response to simple cognitive challenge. This interpretation is consistent with the concept of psychomotor efficiency proposed by Hatfield and Hillman [The psychophysiology of sport: a mechanistic understanding of the psychology of superior performance. In: Singer RN, Hausenbias HA, Janelle CM, editors. Handbook of sport psychology. 2nd ed. New York: Wiley; 2001, p. 362-88].
Production process stability - core assumption of INDUSTRY 4.0 concept
NASA Astrophysics Data System (ADS)
Chromjakova, F.; Bobak, R.; Hrusecka, D.
2017-06-01
Today’s industrial enterprises are confronted by implementation of INDUSTRY 4.0 concept with basic problem - stabilised manufacturing and supporting processes. Through this phenomenon of stabilisation, they will achieve positive digital management of both processes and continuously throughput. There is required structural stability of horizontal (business) and vertical (digitized) manufacturing processes, supported through digitalised technologies of INDUSTRY 4.0 concept. Results presented in this paper based on the research results and survey realised in more industrial companies. Following will described basic model for structural process stabilisation in manufacturing environment.
Learning basic programming using CLIS through gamification
NASA Astrophysics Data System (ADS)
Prabawa, H. W.; Sutarno, H.; Kusnendar, J.; Rahmah, F.
2018-05-01
The difficulty of understanding programming concept is a major problem in basic programming lessons. Based on the results of preliminary studies, 60% of students reveal the monotonous of learning process caused by the limited number of media. Children Learning in Science (CLIS) method was chosen as solution because CLIS has facilitated students’ initial knowledge to be optimized into conceptual knowledge. Technological involvement in CLIS (gamification) helped students to understand basic programming concept. This research developed a media using CLIS method with gamification elements to increase the excitement of learning process. This research declared that multimedia is considered good by students, especially regarding the mechanical aspects of multimedia, multimedia elements and aspects of multimedia information structure. Multimedia gamification learning with the CLIS model showed increased number of students’ concept understanding.
An Analysis of Teachers' Concept Confusion Concerning Electric and Magnetic Fields
ERIC Educational Resources Information Center
Hekkenberg, Ans; Lemmer, Miriam; Dekkers, Peter
2015-01-01
In an exploratory study, 36 South African physical science teachers' understanding of basic concepts concerning electric and magnetic fields was studied from a perspective of possible concept confusion. Concept confusion is said to occur when features of one concept are incorrectly attributed to a different concept, in the case of this study to…
TAF1, From a General Transcription Factor to Modulator of Androgen Receptor in Prostate Cancer
2010-02-01
kinase CK2. Mol Cell Biochem 316:99-106 21. Lively TN, Ferguson HA, Galasinski SK, Seto AG, Goodrich JA 2001 c-Jun binds the N terminus of human TAF(II...Nguyen TN, Galasinski SK, Goodrich JA 2004 The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with
Development of a prototype two-phase thermal bus system for Space Station
NASA Technical Reports Server (NTRS)
Myron, D. L.; Parish, R. C.
1987-01-01
This paper describes the basic elements of a pumped two-phase ammonia thermal control system designed for microgravity environments, the development of the concept into a Space Station flight design, and design details of the prototype to be ground-tested in the Johnson Space Center (JSC) Thermal Test Bed. The basic system concept is one of forced-flow heat transport through interface heat exchangers with anhydrous ammonia being pumped by a device expressly designed for two-phase fluid management in reduced gravity. Control of saturation conditions, and thus system interface temperatures, is accomplished with a single central pressure regulating valve. Flow control and liquid inventory are controlled by passive, nonelectromechanical devices. Use of these simple control elements results in minimal computer controls and high system reliability. Building on the basic system concept, a brief overview of a potential Space Station flight design is given. Primary verification of the system concept will involve testing at JSC of a 25-kW ground test article currently in fabrication.
Swinford, A E; McKeag, D B
1990-01-01
There has been recent interest in the development of problem-based human genetics curricula in U.S. medical schools. The College of Human Medicine at Michigan State University has had a problem-based curriculum since 1974. The vertical integration of genetics within the problem-based curriculum, called "Track II," has recently been revised. On first inspection, the curriculum appeared to lack a significant genetics component; however, on further analysis it was found that many genetics concepts were covered in the biochemistry, microbiology, pathology, and clinical science components. Both basic science concepts and clinical applications of genetics are covered in the curriculum by providing appropriate references for basic concepts and including inherited conditions within the differential diagnosis in the cases studied. Evaluations consist of a multiple-choice content exam and a modified essay exam based on a clinical case, allowing evaluation of both basic concepts and problem-solving ability. This curriculum prepares students to use genetics in a clinical context in their future careers. PMID:2220816
Survey of Basic Education in Eastern Africa. UNESCO/UNICEF Co-Operation Programme.
ERIC Educational Resources Information Center
United Nations Educational, Scientific, and Cultural Organization, Nairobi (Kenya). Regional Office of Science and Technology for Africa.
A survey of basic education in 13 Eastern African countries (Madagascar, Burundi, Comores, Ethiopia, Mauritius, Botswana, Kenya, Lesotho, Swaziland, Tanzania, Zambia, Malawi, and Somalia) covers basic education programs and UNICEF's supporting role. Basic education is seen as a concept evolved in the region, involving formal school systems and…
ERIC Educational Resources Information Center
Morin, Lucien; Cosman, J. W.
The United Nations Standard Minimum Rules for the Treatment of Prisoners do not express the basic principle that would support a serious educational approach to prison administration. The crucial missing rationale is the concept of the inherent dignity of the individual human prisoner. This concept has certain basic educational implications,…
ERIC Educational Resources Information Center
Fokides, Emmanuel
2018-01-01
The study presents the results of a project in which tablets and a ready-made application were used for teaching basic programming concepts to young primary school students (ages 7-9). A total of 135 students participated in the study, attending primary schools in Athens, Greece, divided into three groups. The first was taught conventionally. The…
All about Flight. Physical Science for Children[TM]. Schlessinger Science Library. [Videotape].
ERIC Educational Resources Information Center
2000
Up, up and away! A hot air balloon, an airplane and even the space shuttle all defy the force of gravity, but they all do it in different ways. Children will learn about the basic concepts that make flight possible. With clear demonstrations and a hands-on project, students will be able to understand more easily the basic concepts behind various…
ERIC Educational Resources Information Center
Maherally, Uzma Nooreen
2014-01-01
The purpose of this study was to develop and validate a science assessment tool termed the Life Sciences Assessment (LSA) in order to assess preschool children's conceptions of basic life sciences. The hypothesis was that the four sub-constructs, each of which can be measured through a series of questions on the LSA, will make a significant…
ERIC Educational Resources Information Center
Tsaparlis, Georgios; Papaphotis, Georgios
2009-01-01
This study tested for deep understanding and critical thinking about basic quantum chemical concepts taught at 12th grade (age 17-18). Our aim was to achieve conceptual change in students. A quantitative study was conducted first (n = 125), and following this 23 selected students took part in semi-structured interviews either individually or in…
ERIC Educational Resources Information Center
Kucukozer, Huseyin; Korkusuz, M. Emin; Kucukozer, H. Asuman; Yurumezoglu, Kemal
2009-01-01
This study has examined the impact of teaching certain basic concepts of astronomy through a predict-observe-explain strategy, which includes three-dimensional (3D) computer modeling and observations on conceptual changes seen in sixth-grade elementary school children (aged 11-13; number of students: 131). A pre- and postastronomy instruction…
Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering.
Huang, Di; Zuo, Yi; Zou, Qin; Wang, Yanying; Gao, Shibo; Wang, Xiaoyan; Liu, Haohuai; Li, Yubao
2012-01-01
High porosity of scaffold is always accompanied by poor mechanical property; the aim of this study was to enhance the strength and modulus of the highly porous scaffold of nanohydroxyapatite/polyamide66 (n-HA/PA66) by coating chitosan (CS) and to investigate the effect of CS content on the scaffold physical properties and cytological properties. The results show that CS coating can reinforce the scaffold effectively. The compress modulus and strength of the CS coated n-HA/PA66 scaffolds are improved to 32.71 and 2.38 MPa, respectively, being about six times and five times of those of the uncoated scaffolds. Meanwhile, the scaffolds still exhibit a highly interconnected porous structure and the porosity is approximate about 78%, slightly lower than the value (84%) of uncoated scaffold. The cytological properties of scaffolds were also studied in vitro by cocultured with osteoblast-like MG63 cells. The cytological experiments demonstrate that the reinforced scaffolds display favorable cytocompatibility and have no significant difference with the uncoated n-HA/PA66 scaffolds. The CS reinforced n-HA/PA66 scaffolds can meet the basic mechanical requirement of bone tissue engineering scaffold, presenting a potential for biomedical application in bone reconstruction and repair. Copyright © 2011 Wiley Periodicals, Inc.
Flowmeter evaluation for on-orbit operations
NASA Technical Reports Server (NTRS)
Baird, R. S.
1988-01-01
Various flowmetering concepts were flow tested to characterize the relative capabilities and limitations for on-orbit fluid-transfer operations. Performance results and basic operating principles of each flowmetering concept tested are summarized, and basic considerations required to select the best flowmeter(s) for fluid system application are discussed. Concepts tested were clamp-on ultrasonic, area averaging ultrasonic, offset ultrasonic, coriolis mass, vortex shedding, universal venturi tube, turbine, bearingless turbine, turbine/turbine differential-pressure hybrid, dragbody, and dragbody/turbine hybrid flowmeters. Fluid system flowmeter selection considerations discussed are flowmeter performance, fluid operating conditions, systems operating environments, flowmeter packaging, flowmeter maintenance, and flowmeter technology. No one flowmetering concept tested was shown to be best for all on-orbit fluid systems.
Citation Indexing and Threshold Concepts: An Essential Ah-Ha in Student Learning
ERIC Educational Resources Information Center
McLaughlin, Jeremy L.; Tucker, Virginia M.
2017-01-01
Understanding information organization is a key component to navigating digital library environments as an information professional. While traditionally thought of within the areas of assessment and evaluation, citation indexing is another form of organization and navigation, and learning about it can transform one's knowledge of the information…
Habitat typing versus advanced vegetation classification in western forests
Tony Kusbach; John Shaw; James Long; Helga Van Miegroet
2012-01-01
Major habitat and community types in northern Utah were compared with plant alliances and associations that were derived from fidelity- and diagnostic-species classification concepts. Each of these classification approaches was associated with important environmental factors. Within a 20,000-ha watershed, 103 forest ecosystems were described by physiographic features,...
Improving nitrogen management via a regional management plan for Chinese rice production
NASA Astrophysics Data System (ADS)
Wu, Liang; Chen, Xinping; Cui, Zhenling; Wang, Guiliang; Zhang, Weifeng
2015-09-01
A lack of basic information on optimal nitrogen (N) management often results in over- or under-application of N fertilizer in small-scale intensive rice farming. Here, we present a new database of N input from a survey of 6611 small-scale rice farmers and rice yield in response to added N in 1177 experimental on-farm tests across eight agroecological subregions of China. This database enables us to evaluate N management by farmers and develop an optimal approach to regional N management. We also investigated grain yield, N application rate, and estimated greenhouse gas (GHG) emissions in comparison to N application and farming practices. Across all farmers, the average N application rate, weighted by the area of rice production in each subregion, was 210 kg ha-1 and ranged from 30 to 744 kg ha-1 across fields and from 131 to 316 kg ha-1 across regions. The regionally optimal N rate (RONR) determined from the experiments averaged 167 kg ha-1 and varied from 114 to 224 kg N ha-1 for the different regions. If these RONR were widely adopted in China, approximately 56% of farms would reduce their use of N fertilizer, and approximately 33% would increase their use of N fertilizer. As a result, grain yield would increase by 7.4% from 7.14 to 7.67 Mg ha-1, and the estimated GHG emissions would be reduced by 11.1% from 1390 to 1236 kg carbon dioxide (CO2) eq Mg-1 grain. These results suggest that to achieve the goals of improvement in regional yield and sustainable environmental development, regional N use should be optimized among N-poor and N-rich farms and regions in China.
Basile, Maria Assunta; d'Ayala, Giovanna Gomez; Laurienzo, Paola; Malinconico, Mario; Della Ragione, Fulvio; Oliva, Adriana
2012-01-01
In the framework of a project aiming to improve the properties of poly(ε-caprolactone) (PCL)-based devices, we prepared novel composites and tested their in vitro biocompatibility and osteogenic capacity on human mesenchymal stromal cells (MSC) from bone marrow. We prepared two functionalized derivatives, PCL-g-MAGMA and PCL-g-DMAEA, by insertion of anhydride groups by radical grafting of maleic anhydride (MA) and glycidyl-methacrylate (GMA) molecules, and by insertion of N-(dimethylamino)ethylacrylate (DMAEA) of tertiary amines groups, respectively. In addition, in order to improve the osteoconductive properties of the materials, we also prepared the corresponding composites containing the mineral component of bone, namely hydroxyapatite (HA). Mesenchymal stromal cells (MSC) derived from bone marrow were prepared, plated onto a number of discs obtained from these functionalized derivatives and tested in terms of adhesion and vitality (by MTT test and SEM observation), and the expression of alkaline phosphatase, the early marker of osteoblastic phenotype. The biological in vitro assessment of the functionalized materials, PCL-g-MAGMA and PCL-g-DMAEA, appeared promising only in part, in particular the cells exhibited very poor adhesion to PCL-g-MAGMA. On the contrary, the related composites, PCL-g-MAGMA-HA and PCL-g-DMAEA-HA clearly showed that the addition of HA greatly ameliorated the cell-material interaction. In particular, a surprisingly increased response characterized PCL-g-MAGMA-HA, either in terms of adhesion and vitality or in terms of alkaline phosphatase activity. Altogether these studies showed that the addition of HA nanowhiskers resulted for all basic materials, in particular PCL-g-MAGMA, in improved cell adhesion and performance.
Trade-offs between high yields and greenhouse gas emissions in irrigation wheat cropland in China
NASA Astrophysics Data System (ADS)
Cui, Z. L.; Wu, L.; Ye, Y. L.; Ma, W. Q.; Chen, X. P.; Zhang, F. S.
2014-04-01
Although the concept of producing higher yields with reduced greenhouse gas (GHG) emissions is a goal that attracts increasing public and scientific attention, the trade-off between high yields and GHG emissions in intensive agricultural production is not well understood. Here, we hypothesize that there exists a mechanistic relationship between wheat grain yield and GHG emission, and that could be transformed into better agronomic management. A total 33 sites of on-farm experiments were investigated to evaluate the relationship between grain yield and GHG emissions using two systems (conventional practice, CP; high-yielding systems, HY) of intensive winter wheat (Triticum aestivum L.) in China. Furthermore, we discussed the potential to produce higher yields with lower GHG emissions based on a survey of 2938 farmers. Compared to the CP system, grain yield was 39% (2352 kg ha-1) higher in the HY system, while GHG emissions increased by only 10%, and GHG emission intensity was reduced by 21%. The current intensive winter wheat system with farmers' practice had a median yield and maximum GHG emission rate of 6050 kg ha-1 and 4783 kg CO2 eq ha-1, respectively; however, this system can be transformed to maintain yields while reducing GHG emissions by 26% (6077 kg ha-1, and 3555 kg CO2 eq ha-1). Further, the HY system was found to increase grain yield by 39% with a simultaneous reduction in GHG emissions by 18% (8429 kg ha-1, and 3905 kg CO2 eq ha-1, respectively). In the future, we suggest moving the trade-off relationships and calculations from grain yield and GHG emissions to new measures of productivity and environmental protection using innovative management technologies.
Stridh, Sara; Palm, Fredrik
2013-01-01
Background. Hyaluronan (HA) is the dominant glycosaminoglycan in the renomedullary interstitium. Renomedullary HA has been implicated in tubular fluid handling due to its water-attracting properties and the changes occurring in parallel to acute variations in the body hydration status. Methods. HA production was inhibited by 4-methylumbelliferone (4-MU in drinking water for 5 days, 1.45 ± 0.07 g/day/kg body weight) in rats prior to hydration. Results. Following hypotonic hydration for 135 min in control animals, diuresis and osmotic excretion increased while sodium excretion and glomerular filtration rate (GFR) remained unchanged. The medullary and cortical HA contents were 7.85 ± 1.29 ng/mg protein and 0.08 ± 0.01 ng/mg protein, respectively. Medullary HA content after 4-MU was 38% of that in controls (2.98 ± 0.95 ng/g protein, p < 0.05), while the low cortical levels were unaffected. Baseline urine flow was not different from that in controls. The diuretic response to hydration was, however, only 51% of that in controls (157 ± 36 versus 306 ± 54 µl/g kidney weight/135 min, p < 0.05) and the osmolar excretion only 47% of that in controls (174 ± 47 versus 374 ± 41 µOsm/g kidney weight/135 min, p < 0.05). Sodium excretion, GFR, and arterial blood pressure were similar to that in control rats and unaltered during hydration. Conclusions. Reduction of renomedullary interstitial HA using 4-MU reduces the ability of the kidney to respond appropriately upon acute hydration. The results strengthen the concept of renomedullary HA as a modulator of tubular fluid handling by changing the physicochemical properties of the interstitial space. PMID:24102146
Mastbergen, Simon C; Jones, Elena; Calder, Stuart J; Lafeber, Floris P J G; McGonagle, Dennis
2016-01-01
Objectives Knee joint distraction (KJD) is a novel, but poorly understood, treatment for osteoarthritis (OA) associated with remarkable ‘spontaneous’ cartilage repair in which resident synovial fluid (SF) multipotential mesenchymal stromal cells (MSCs) may play a role. We hypothesised that SF hyaluronic acid (HA) inhibited the initial interaction between MSCs and cartilage, a key first step to integration, and postulate that KJD environment favoured MSC/cartilage interactions. Methods Attachment of dual-labelled SF-MSCs were assessed in a novel in vitro human cartilage model using OA and rheumatoid arthritic (RA) SF. SF was digested with hyaluronidase (hyase) and its effect on adhesion was observed using confocal microscopy. MRI and microscopy were used to image autologous dual-labelled MSCs in an in vivo canine model of KJD. SF-HA was investigated using gel electrophoresis and densitometry. Results Osteoarthritic-synovial fluid (OA-SF) and purified high molecular weight (MW) HA inhibited SF-MSC adhesion to plastic, while hyase treatment of OA-SF but not RA-SF significantly increased MSC adhesion to cartilage (3.7-fold, p<0.05) These differences were linked to the SF mediated HA-coat which was larger in OA-SF than in RA-SF. OA-SF contained >9 MDa HA and this correlated with increases in adhesion (r=0.880). In the canine KJD model, MSC adhesion to cartilage was evident and also dependent on HA MW. Conclusions These findings highlight an unappreciated role of SF-HA on MSC interactions and provide proof of concept that endogenous SF-MSCs are capable of adhering to cartilage in a favourable biochemical and biomechanical environment in OA distracted joints, offering novel one-stage strategies towards joint repair. PMID:25948596
Mochalova, Larisa; Harder, Timm; Tuzikov, Alexander; Bovin, Nicolai; Wolff, Thorsten; Matrosovich, Mikhail; Schweiger, Brunhilde
2015-01-01
ABSTRACT Highly pathogenic avian influenza viruses (HPAIVs) of hemagglutinin H5 and H7 subtypes emerge after introduction of low-pathogenic avian influenza viruses (LPAIVs) from wild birds into poultry flocks, followed by subsequent circulation and evolution. The acquisition of multiple basic amino acids at the endoproteolytical cleavage site of the hemagglutinin (HA) is a molecular indicator for high pathogenicity, at least for infections of gallinaceous poultry. Apart from the well-studied significance of the multibasic HA cleavage site, there is only limited knowledge on other alterations in the HA and neuraminidase (NA) molecules associated with changes in tropism during the emergence of HPAIVs from LPAIVs. We hypothesized that changes in tropism may require alterations of the sialyloligosaccharide specificities of HA and NA. To test this hypothesis, we compared a number of LPAIVs and HPAIVs for their HA-mediated binding and NA-mediated desialylation of a set of synthetic receptor analogs, namely, α2-3-sialylated oligosaccharides. NA substrate specificity correlated with structural groups of NAs and did not correlate with pathogenic potential of the virus. In contrast, all HPAIVs differed from LPAIVs by a higher HA receptor-binding affinity toward the trisaccharides Neu5Acα2-3Galβ1-4GlcNAcβ (3′SLN) and Neu5Acα2-3Galβ1-3GlcNAcβ (SiaLec) and by the ability to discriminate between the nonfucosylated and fucosylated sialyloligosaccharides 3′SLN and Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ (SiaLex), respectively. These results suggest that alteration of the receptor-binding specificity accompanies emergence of the HPAIVs from their low-pathogenic precursors. IMPORTANCE Here, we have found for the first time correlations of receptor-binding properties of the HA with a highly pathogenic phenotype of poultry viruses. Our study suggests that enhanced receptor-binding affinity of HPAIVs for a typical “poultry-like” receptor, 3′SLN, is provided by substitutions in the receptor-binding site of HA which appeared in HA of LPAIVs in the course of transmission of LPAIVs from wild waterfowl into poultry flocks, with subsequent adaptation in poultry. The identification of LPAIVs with receptor characteristics of HPAIVs argues that the sialic acid-binding specificity of the HA may be used as a novel phenotypic marker of HPAIVs. PMID:25741006
Death, dignity, and moral nonsense.
Pullman, Daryl
2004-01-01
Although the concept of human dignity is widely invoked in discussions regarding end-of-life decision making, the content of the notion is ambiguous. Such ambiguity has led some to conclude that human dignity is a redundant or even useless concept that we would be better off without. This paper argues, to the contrary, that the concept of human dignity is indispensable to moral discourse. Far from dispensing with human dignity, we must work to clarify the concept. The paper outlines two distinct but related conceptions of dignity that are often conflated in contemporary moral discourse. These conceptions are labelled "basic dignity" and "personal dignity", respectively. It is argued that basic dignity functions as a universal meaning constraint on moral discourse in general. Hence, to dispense with the notion could reduce us to speaking moral nonsense. Throughout the discussion, some implications for our understanding of end-of-life decision making are explored.
Health as a basic human need: would this be enough?
de Campos, Thana Cristina
2012-01-01
Although the value of health is universally agreed upon, its definition is not. Both the WHO and the UN define health in terms of well-being. They advocate a globally shared responsibility that all of us - states, international organizations, pharmaceutical corporations, civil society, and individuals - bear for the health (that is, the well-being) of the world's population. In this paper I argue that this current well-being conception of health is troublesome. Its problem resides precisely in the fact that the well-being conception of health, as an all-encompassing label, does not properly distinguish between the different realities of health and the different demands of justice, which arise in each case. In addressing responsibilities related to the right to health, we need to work with a more differentiated vocabulary, which can account for these different realities. A crucial distinction to bear in mind, for the purposes of moral deliberation and the crafting of political and legal institutions, is the difference between basic and non-basic health needs. This distinction is crucial because we have presumably more stringent obligations and rights in relation to human needs that are basic, as they justify stronger moral claims, than those grounded on non-basic human needs. It is important to keep this moral distinction in mind because many of the world's problems regarding the right to health relate to basic health needs. By conflating these needs with less essential ones, we risk confusing different types of moral claims and weakening the overall case for establishing duties regarding the right to health. There is, therefore, a practical need to reevaluate the current normative conception of health so that it distinguishes, within the broad scope of well-being, between what is basic and what is not. My aim here is to shed light onto this distinction and to show the need for this differentiation. I do so, first, by providing, on the basis of David Miller's concept of basic needs, an account of basic health needs and, secondly, by mounting a defense of the basic needs approach to the right to health, arguing against James Griffin who opposes the basic needs approach. © 2012 American Society of Law, Medicine & Ethics, Inc.
[Nurse's concept in the managerial conception of a basic health unit].
Passos, Joanir Pereira; Ciosak, Suely Itsuko
2006-12-01
This study is part of a larger survey called "Use of indicators in nurses' managerial practice in Basic Health Care Units in the city of Rio de Janeiro", which was carried out in the Basic Health Care Units of the Planning Area 5.3 and whose objectives were to identify nurses' conception regarding the tools required for management in those units and to discuss the role of management in organizing health services. The study is descriptive and data were collected in interviews with seven nurse managers. The results show that health services actions are organized and directed to the purpose of the working process through the relationship established between the object, the instruments and the final product, and that for those nurses the end result to be achieved is client's satisfaction and the quality of medical and nursing care.
Cause and Effect: Testing a Mechanism and Method for the Cognitive Integration of Basic Science.
Kulasegaram, Kulamakan; Manzone, Julian C; Ku, Cheryl; Skye, Aimee; Wadey, Veronica; Woods, Nicole N
2015-11-01
Methods of integrating basic science with clinical knowledge are still debated in medical training. One possibility is increasing the spatial and temporal proximity of clinical content to basic science. An alternative model argues that teaching must purposefully expose relationships between the domains. The authors compared different methods of integrating basic science: causal explanations linking basic science to clinical features, presenting both domains separately but in proximity, and simply presenting clinical features First-year undergraduate health professions students were randomized to four conditions: (1) science-causal explanations (SC), (2) basic science before clinical concepts (BC), (3) clinical concepts before basic science (CB), and (4) clinical features list only (FL). Based on assigned conditions, participants were given explanations for four disorders in neurology or rheumatology followed by a memory quiz and diagnostic test consisting of 12 cases which were repeated after one week. Ninety-four participants completed the study. No difference was found on memory test performance, but on the diagnostic test, a condition by time interaction was found (F[3,88] = 3.05, P < .03, ηp = 0.10). Although all groups had similar immediate performance, the SC group had a minimal decrease in performance on delayed testing; the CB and FL groups had the greatest decreases. These results suggest that creating proximity between basic science and clinical concepts may not guarantee cognitive integration. Although cause-and-effect explanations may not be possible for all domains, making explicit and specific connections between domains will likely facilitate the benefits of integration for learners.
Thermal evaluation of advanced solar dynamic heat receiver performance
NASA Technical Reports Server (NTRS)
Crane, Roger A.
1989-01-01
The thermal performance of a variety of concepts for thermal energy storage as applied to solar dynamic applications is discussed. It is recognized that designs providing large thermal gradients or large temperature swings during orbit are susceptible to early mechanical failure. Concepts incorporating heat pipe technology may encounter operational limitations over sufficiently large ranges. By reviewing the thermal performance of basic designs, the relative merits of the basic concepts are compared. In addition the effect of thermal enhancement and metal utilization as applied to each design provides a partial characterization of the performance improvements to be achieved by developing these technologies.
A basic recursion concept inventory
NASA Astrophysics Data System (ADS)
Hamouda, Sally; Edwards, Stephen H.; Elmongui, Hicham G.; Ernst, Jeremy V.; Shaffer, Clifford A.
2017-04-01
Recursion is both an important and a difficult topic for introductory Computer Science students. Students often develop misconceptions about the topic that need to be diagnosed and corrected. In this paper, we report on our initial attempts to develop a concept inventory that measures student misconceptions on basic recursion topics. We present a collection of misconceptions and difficulties encountered by students when learning introductory recursion as presented in a typical CS2 course. Based on this collection, a draft concept inventory in the form of a series of questions was developed and evaluated, with the question rubric tagged to the list of misconceptions and difficulties.
ERIC Educational Resources Information Center
Horner, Bruce; Lu, Min-Zhan
Intended for teachers of basic writing, this book contains a collection of new and updated essays addressing issues surrounding underprepared writers. It maps errors and expectations for basic writing and develops teaching approaches that will be effective in a social and political world. The book considers concepts such as the possibility of…
Basic Science Living Skills for Today's World. Teacher's Edition.
ERIC Educational Resources Information Center
Zellers (Robert W.) Educational Services, Johnstown, PA.
This document is a teacher's edition of a basic skills curriculum in science for adult basic education (ABE) students. The course consists of 25 lessons on basic science concepts, designed to give students a good understanding of the biological and physical sciences. Suggested activities and experiments that the student can do are also included.…
ERIC Educational Resources Information Center
Paz, Benito Castejon; And Others
The major aim of this study is to devise a model for rationalizing sports policies by defining the basic concepts that should be inherent in any proper sports policy despite the infinite diversity that characterizes actual sport situations. The first part of the study discusses three concepts which are basic to the model: a) the "level of sport"…
Experiencing Economic Concepts: Formal and Informal Concept Learning.
ERIC Educational Resources Information Center
Armento, Beverly Jeanne
1980-01-01
This article discusses the feasibility of and the skills needed for teaching basic economic concepts such as supply and demand in an informal learning situation, in this case the simulation of an economic system based on barter. (CJ)
Professionalism as an Organizational Concept.
ERIC Educational Resources Information Center
Beam, Randal A.
Although professionalism has been an important concept to American journalists for over a century, no consensus exists regarding what concepts like profession, professionalism, and professionalization mean. Three basic traditions have dominated the sociological literature on professionalism: (1) the phenomenological approach, which advocates…
Eisenbarth, Sophie; Tilling, Thomas; Lueerss, Eva; Meyer, Jelka; Sehner, Susanne; Guse, Andreas H; Guse Nee Kurré, Jennifer
2016-04-29
Heterogeneous basic science knowledge of medical students is an important challenge for medical education. In this study, the authors aimed at exploring the value and role of integrated supportive science (ISS) courses as a novel approach to address this challenge and to promote learning basic science concepts in medical education. ISS courses were embedded in a reformed medical curriculum. The authors used a mixed methods approach including four focus groups involving ISS course lecturers and students (two each), and five surveys of one student cohort covering the results of regular student evaluations including the ISS courses across one study year. They conducted their study at the University Medical Center Hamburg-Eppendorf between December 2013 and July 2014. Fourteen first-year medical students and thirteen ISS course lecturers participated in the focus groups. The authors identified several themes focused on the temporal integration of ISS courses into the medical curriculum, the integration of ISS course contents into core curriculum contents, the value and role of ISS courses, and the courses' setting and atmosphere. The integrated course concept was positively accepted by both groups, with participants suggesting that it promotes retention of basic science knowledge. Values and roles identified by focus group participants included promotion of basic understanding of science concepts, integration of foundational and applied learning, and maximization of students' engagement and motivation. Building close links between ISS course contents and the core curriculum appeared to be crucial. Survey results confirmed qualitative findings regarding students' satisfaction, with some courses still requiring optimization. Integration of supportive basic science courses, traditionally rather part of premedical education, into the medical curriculum appears to be a feasible strategy to improve medical students' understanding of basic science concepts and to increase their motivation and engagement.
Zhang, Minglei; Wang, Dapeng; Yin, Ruofeng
2015-10-06
To explorec Histocompatibility of nano-hydroxyapatite/poly-co-glycolic acid tissue engineering bone modified by mesenchymal stem cells with vascular endothelial frowth factor transinfected. Rat bone marrow mesenchymal stem cells (BMSCs) was separated, using BMSCs as target cells, and then vascular endothelial growth factor (VEGF) gene was transfected. Composite bone marrow mesenchymal stem cells and cells transfected with nano-hydroxyapatite (HA)/polylactic-co-glycolic acid (PLGA). The composition of cell and scaffold was observed. The blank plasmid transfection was 39.1%, 40.1% in VEGF group. The cell adhesion and growth was found on the scaffold pore wall after 5 days, and the number of adherent cells in the nano-HA/PLGA composite scaffold material basically had no significant difference in both. Although the nano-HA/PLGA scaffold material is still not fully meet the requirements of the matrix material for bone tissue engineering, but good biocompatibility, structure is its rich microporous satisfaction in material mechanics, toughening, enhanced obviously. Composition scaffold with BMSCs transfected by VEGF plasmid, the ability of angiogenesis is promoted.
Significant and Basic Innovations in Urban Planning
NASA Astrophysics Data System (ADS)
Kolyasnikov, V. A.
2017-11-01
The article considers the development features of the innovative urban planning in the USSR and Russia in XVIII - XX centuries. Innovative urban planning is defined as an activity on innovations creation and their implementation to obtain a socio-economic, political, environmental or other effect. In the course of urban development history this activity represents a cyclic wave process in which there are phases of rise and fall. The study of cyclic waves in the development of innovative urban planning uses the concept of basic and epochal innovations selection. This concept was developed by scientists for the study of cyclic wave processes in economics. Its adaptation to the conditions of innovative urban planning development allows one to introduce the concept of “basic innovation” and “significant innovation” in the theory and practice of settlement formation and their systems as well as to identify opportunities to highlight these innovations in the history of Russian urban planning. From these positions, six innovation waves committed to the urban development over the past 300 years are being investigated. The observed basic innovations in the domestic urban area show that urban development is a vital area for ensuring the country’s geopolitical security. Basic innovations are translated in time and modernized under new conditions of urban planning development. In this regard, we can predict the development of four basic innovations in post-Soviet Russia.
NASA Astrophysics Data System (ADS)
Wei, Yajun; Zhai, Zhaohui; Gunnarsson, Klas; Svedlindh, Peter
2014-11-01
Basic concepts concerning magnetic hysteresis are of vital importance in understanding magnetic materials. However, these concepts are often misinterpreted by many students and even textbooks. We summarize the most common misconceptions and present a new approach to help clarify these misconceptions and enhance students’ understanding of the hysteresis loop. In this approach, students are required to perform an experiment and plot the measured magnetization values and thereby calculated demagnetizing field, internal field, and magnetic induction as functions of the applied field point by point on the same graph. The concepts of the various coercivity, remanence, saturation magnetization, and saturation induction will not be introduced until this stage. By plotting this graph, students are able to interlink all the preceding concepts and intuitively visualize the underlying physical relations between them.
Methane oxidation at a surface-sealed boreal landfill.
Einola, Juha; Sormunen, Kai; Lensu, Anssi; Leiskallio, Antti; Ettala, Matti; Rintala, Jukka
2009-07-01
Methane oxidation was studied at a closed boreal landfill (area 3.9 ha, amount of deposited waste 200,000 tonnes) equipped with a passive gas collection and distribution system and a methane oxidative top soil cover integrated in a European Union landfill directive-compliant, multilayer final cover. Gas wells and distribution pipes with valves were installed to direct landfill gas through the water impermeable layer into the top soil cover. Mean methane emissions at the 25 measuring points at four measurement times (October 2005-June 2006) were 0.86-6.2 m(3) ha(-1) h(-1). Conservative estimates indicated that at least 25% of the methane flux entering the soil cover at the measuring points was oxidized in October and February, and at least 46% in June. At each measurement time, 1-3 points showed significantly higher methane fluxes into the soil cover (20-135 m(3) ha(-1) h(-1)) and methane emissions (6-135 m(3) ha(-1) h(-1)) compared to the other points (< 20 m(3) ha(-1) h(-1) and < 10 m(3) ha(-1) h(-1), respectively). These points of methane overload had a high impact on the mean methane oxidation at the measuring points, resulting in zero mean oxidation at one measurement time (November). However, it was found that by adjusting the valves in the gas distribution pipes the occurrence of methane overload can be to some extent moderated which may increase methane oxidation. Overall, the investigated landfill gas treatment concept may be a feasible option for reducing methane emissions at landfills where a water impermeable cover system is used.
Samadder, Abhimanyu; Kar, Rakhee
2017-01-01
There is considerable inter-observer variability in the diagnosis of molar pregnancies by histomorphological examination of products of conception (POC). The p57KIP2 gene is paternally imprinted and expressed from the maternal allele. On immunohistochemistry (IHC) with p57, complete mole (CM) shows absent staining whereas hydropic abortus (HA) and partial mole (PM) show positive staining. This study was undertaken to evaluate the role of p57 IHC along with histomorphology in differentiating between CM, PM and non-molar or HA. This was a cross-sectional study over a period of three and a half years on archival material. Detailed histomorphological review along with p57 IHC was carried out in 28 diagnosed cases (23 CM, 4 PM and 1 molar pregnancy not categorized) and 25 controls of four normal placentas and 21 POC (8 non-hydropic and 13 HA). In 14.8 per cent (4/27) cases, there was discordance in accurate subtyping of molar pregnancy. One case of CM showed inconsistent IHC pattern. In 15.4 per cent (2/13) HA, molar pregnancy was final diagnosis. After final review, there were 25 CM, five PM, 22 non-molar controls including 10 HA and one not assigned (PM/HA). IHC with p57 was negative in 96 per cent CM and positive in 100 and 95 per cent PM and non-molar controls, respectively. This study showed that negative p57KIP2 immunostaining reliably identified CM and could be used in association with the histological findings to distinguish CM from its mimics.
Yeon, Yeung Kyu; Park, Hae Sang; Lee, Jung Min; Lee, Ji Seung; Lee, Young Jin; Sultan, Md Tipu; Seo, Ye Bin; Lee, Ok Joo; Kim, Soon Hee; Park, Chan Hum
Open reduction with internal fixation is commonly used for the treatment of bone fractures. However, postoperative infection associated with internal fixation devices (intramedullary nails, plates, and screws) remains a significant complication, and it is technically difficult to fix multiple fragmented bony fractures using internal fixation devices. In addition, drilling in the bone to install devices can lead to secondary fracture, bone necrosis associated with postoperative infection. In this study, we developed bone clip type internal fixation device using three- dimensional (3D) printing technology. Standard 3D model of the bone clip was generated based on computed tomography (CT) scan of the femur in the rat. Polylacticacid (PLA), hydroxyapatite (HA), and silk were used for bone clip material. The purpose of this study was to characterize 3D printed PLA, PLA/HA, and PLA/HA/Silk composite bone clip and evaluate the feasibility of these bone clips as an internal fixation device. Based on the results, PLA/HA/Silk composite bone clip showed similar mechanical property, and superior biocompatibility compared to other types of the bone clip. PLA/HA/Silk composite bone clip demonstrated excellent alignment of the bony segments across the femur fracture site with well-positioned bone clip in an animal study. Our 3D printed bone clips have several advantages: (1) relatively noninvasive (drilling in the bone is not necessary), (2) patient-specific design (3) mechanically stable device, and (4) it provides high biocompatibility. Therefore, we suggest that our 3D printed PLA/HA/Silk composite bone clip is a possible internal fixation device.
Global search and rescue - A new concept. [orbital digital radar system with passive reflectors
NASA Technical Reports Server (NTRS)
Sivertson, W. E., Jr.
1976-01-01
A new terrestrial search and rescue concept is defined embodying the use of simple passive radiofreqeuncy reflectors in conjunction with a low earth-orbiting, all-weather, synthetic aperture radar to detect, identify, and position locate earth-bound users in distress. Users include ships, aircraft, small boats, explorers, hikers, etc. Airborne radar tests were conducted to evaluate the basic concept. Both X-band and L-band, dual polarization radars were operated simultaneously. Simple, relatively small, corner-reflector targets were successfully imaged and digital data processing approaches were investigated. Study of the basic concept and evaluation of results obtained from aircraft flight tests indicate an all-weather, day or night, global search and rescue system is feasible.
Contexts, concepts and cognition: principles for the transfer of basic science knowledge.
Kulasegaram, Kulamakan M; Chaudhary, Zarah; Woods, Nicole; Dore, Kelly; Neville, Alan; Norman, Geoffrey
2017-02-01
Transfer of basic science aids novices in the development of clinical reasoning. The literature suggests that although transfer is often difficult for novices, it can be optimised by two complementary strategies: (i) focusing learners on conceptual knowledge of basic science or (ii) exposing learners to multiple contexts in which the basic science concepts may apply. The relative efficacy of each strategy as well as the mechanisms that facilitate transfer are unknown. In two sequential experiments, we compared both strategies and explored mechanistic changes in how learners address new transfer problems. Experiment 1 was a 2 × 3 design in which participants were randomised to learn three physiology concepts with or without emphasis on the conceptual structure of basic science via illustrative analogies and by means of one, two or three contexts during practice (operationalised as organ systems). Transfer of these concepts to explain pathologies in familiar organ systems (near transfer) and unfamiliar organ systems (far transfer) was evaluated during immediate and delayed testing. Experiment 2 examined whether exposure to conceptual analogies and multiple contexts changed how learners classified new problems. Experiment 1 showed that increasing context variation significantly improved far transfer performance but there was no difference between two and three contexts during practice. Similarly, the increased conceptual analogies led to higher performance for far transfer. Both interventions had independent but additive effects on overall performance. Experiment 2 showed that such analogies and context variation caused learners to shift to using structural characteristics to classify new problems even when there was superficial similarity to previous examples. Understanding problems based on conceptual structural characteristics is necessary for successful transfer. Transfer of basic science can be optimised by using multiple strategies that collectively emphasise conceptual structure. This means teaching must focus on conserved basic science knowledge and de-emphasise superficial features. © 2017 John Wiley & Sons Ltd and The Association for the Study of Medical Education.
TRI Fotonovela Slideshow - English
Presentation designed to introduce the basic concepts of the Toxics Release Inventory, including why TRI is an important resource for commmunities and which tool provides the easiest access to basic TRI data.
Basic Electricity--a Novel Analogy.
ERIC Educational Resources Information Center
Grant, Richard
1996-01-01
Uses the analogy of water flow to introduce concepts in basic electricity. Presents a demonstration that uses this analogy to help students grasp the relationship between current, voltage, and resistance. (JRH)
TRI Fotonovela Slideshow - Spanish
Presentation designed to introduce the basic concepts of the Toxics Release Inventory, including why TRI is an important resource for commmunities and which tool provides the easiest access to basic TRI data.
ERIC Educational Resources Information Center
Papaphotis, Georgios; Tsaparlis, Georgios
2008-01-01
Part 1 of the findings are presented of a quantitative study (n = 125) on basic quantum chemical concepts taught in the twelfth grade (age 17-18 years) in Greece. A paper-and-pencil test of fourteen questions was used. The study compared performance in five questions that tested recall of knowledge or application of algorithmic procedures (type-A…
NASA Technical Reports Server (NTRS)
Iliff, Kenneth W.
1987-01-01
The aircraft parameter estimation problem is used to illustrate the utility of parameter estimation, which applies to many engineering and scientific fields. Maximum likelihood estimation has been used to extract stability and control derivatives from flight data for many years. This paper presents some of the basic concepts of aircraft parameter estimation and briefly surveys the literature in the field. The maximum likelihood estimator is discussed, and the basic concepts of minimization and estimation are examined for a simple simulated aircraft example. The cost functions that are to be minimized during estimation are defined and discussed. Graphic representations of the cost functions are given to illustrate the minimization process. Finally, the basic concepts are generalized, and estimation from flight data is discussed. Some of the major conclusions for the simulated example are also developed for the analysis of flight data from the F-14, highly maneuverable aircraft technology (HiMAT), and space shuttle vehicles.
ERIC Educational Resources Information Center
Jin, Haiyue; Wong, Khoon Yoong
2015-01-01
Conceptual understanding is a major aim of mathematics education, and concept map has been used in non-mathematics research to uncover the relations among concepts held by students. This article presents the results of using concept map to assess conceptual understanding of basic algebraic concepts held by a group of 48 grade 8 Chinese students.…
Introduction to TRI for Communities
Presentation designed to introduce the basic concepts of the Toxics Release Inventory, including why TRI is an important resource for commmunities and which tool provides the easiest access to basic TRI data.
``Physics with a Smile''-Explaining Phenomena with a Qualitative Problem-Solving Strategy
NASA Astrophysics Data System (ADS)
Mualem, Roni; Eylon, Bat-Sheva
2007-03-01
Various studies indicate that high school physics students and even college students majoring in physics have difficulties in qualitative understanding of basic concepts and principles of physics.1-5 For example, studies carried out with the Force Concept Inventory (FCI)1,6 illustrate that qualitative tasks are not easy to solve even at the college level. Consequently, "conceptual physics" courses have been designed to foster qualitative understanding, and advanced high school physics courses as well as introductory college-level courses strive to develop qualitative understanding. Many physics education researchers emphasize the importance of acquiring some qualitative understanding of basic concepts in physics as early as middle school or in the context of courses that offer "Physics First" in the ninth grade before biology or chemistry.7 This trend is consistent with the call to focus the science curriculum on a small number of basic concepts and ideas, and to instruct students in a more "meaningful way" leading to better understanding. Studies7-10 suggest that familiar everyday contexts (see Fig. 1) are useful in fostering qualitative understanding.
Sachro, L L; Strong, W L; Gates, C C
2005-11-01
The effects of prescribed burning on forage abundance and suitability for elk (Cervus elaphus) during the snow-free season was evaluated in east-central Banff National Park, Canada. Six coniferous forest and mixed shrub-herb plant communities (n=144 plots), and 5223ha of burned (n=131) vegetation <12 years old were sampled using a stratified semi-random design. Sampling units represented various combinations of vegetation, terrain conditions, and stand ages that were derived from digital biophysical data, with plant communities the basic unit of analysis. Burning coniferous forest stands reduced woody biomass, and increased herbaceous forage from 146 to 790 kg/ha. Increases commonly occurred in the percent cover of hairy wild rye (Leymus innovatus (Beal) Pigler) and fireweed (Chamerion angustifolium (L.) Holub.). The herbaceous components of mixed shrub-herb communities increased from 336-747 kg/ha to 517-1104 kg/ha in response to burning (P<0.025, Mann-Whitney U-test). Browse biomass (mostly Salix spp. and Betula nana L.) increased >or=220% (P
Teaching basic science to optimize transfer.
Norman, Geoff
2009-09-01
Basic science teachers share the concern that much of what they teach is soon forgotten. Although some evidence suggests that relatively little basic science is forgotten, it may not appear so, as students commonly have difficulty using these concepts to solve or explain clinical problems: This phenomenon, using a concept learned in one context to solve a problem in a different context, is known to cognitive psychologists as transfer. The psychology literature shows that transfer is difficult; typically, even though students may know a concept, fewer than 30% will be able to use it to solve new problems. However a number of strategies to improve transfer can be adopted at the time of initial teaching of the concept, in the use of exemplars to illustrate the concept, and in practice with additional problems. In this article, we review the literature in psychology to identify practical strategies to improve transfer. Critical review of psychology literature to identify factors that enhance or impede transfer. There are a number of strategies available to teachers to facilitate transfer. These include active problem-solving at the time of initial learning, imbedding the concept in a problem context, using everyday analogies, and critically, practice with multiple dissimilar problems. Further, mixed practice, where problems illustrating different concepts are mixed together, and distributed practice, spread out over time, can result in significant and large gains. Transfer is difficult, but specific teaching strategies can enhance this skill by factors of two or three.
E-Basics: Online Basic Training in Program Evaluation
ERIC Educational Resources Information Center
Silliman, Ben
2016-01-01
E-Basics is an online training in program evaluation concepts and skills designed for youth development professionals, especially those working in nonformal science education. Ten hours of online training in seven modules is designed to prepare participants for mentoring and applied practice, mastery, and/or team leadership in program evaluation.…
Developing Basic Math Skills for Marketing. Student Manual and Laboratory Guide.
ERIC Educational Resources Information Center
Klewer, Edwin D.
Field tested with students in grades 10-12, this manual is designed to teach students in marketing courses basic mathematical concepts. The instructional booklet contains seven student assignments covering the following topics: why basic mathematics is so important, whole numbers, fractions, decimals, percentages, weights and measures, and dollars…
Back to the Basics: Kansas City, Missouri
ERIC Educational Resources Information Center
Handley, Lawrence R.; Lockwood, Catherine M.; Handley, Nathan
2004-01-01
"Back to the Basics" is an innovation of the WETMAAP Program (Wetland Education Through Maps and Aerial Photography) which offers a series of workshops that provide training in basics ecological concepts, technological skills, and methods of interpretation necessary for assessing geography and earth science topics. The precept of the…
ERIC Educational Resources Information Center
Federal Reserve Bank of Boston, MA.
The booklet outlines and presents examples of basic economics concepts. Objectives are to help elementary and secondary teachers introduce economic concepts in the classroom and to help teachers grasp some of the fundamentals of economics. The document is divided into seven sections. Each section presents concepts, offers three supporting…
Status of the Space Station environmental control and life support system design concept
NASA Technical Reports Server (NTRS)
Ray, C. D.; Humphries, W. R.
1986-01-01
The current status of the Space Station (SS) environmental control and life support system (ECLSS) design is outlined. The concept has been defined at the subsystem level. Data supporting these definitions are provided which identify general configuratioons for all modules. Requirements, guidelines and assumptions used in generating these configurations are detailed. The basic 2 US module 'core' Space Station is addressed along with system synergism issues and early man-tended and future growth considerations. Along with these basic studies, also addressed here are options related to variation in the 'core' module makeup and more austere Station concepts such as commonality, automation and design to cost.
Reassessment of forest area and its scoring as a permanent production forest
NASA Astrophysics Data System (ADS)
Sudarmadji, T.; Hartati, W.
2018-04-01
Along with the increasing demand for tropical timber, the need for wood raw materials is not enough just to rely on natural forests, and therefore in the early 1990s began to be developed timber estates concessions. The designation of forest areas can basically be altered using procedures established by the Ministry of and Forestry. PT Permata Borneo Abadi (PBA) as the holder of IUPHHK-HT covering 38.680 ha intends to propose changing of forest function from limited production forest (HPT) and convertible production forest (HPK) into permanent production forest (HP) to be developed as timber estates with fast growing species. Reassessment of forest function is intended to formulate official documents aimed to reevaluate IUPHHK-HT especially HPT and HPK. The assessment is based on established criteria and standard values (scores) covering topographic, soil and vegetation conditions as well as regional rainfall distribution. The assessment results indicate that there is an area with a slope of >40% of 840.18 ha with score >175 which must therefore as protected areas. The area of HPT that scored between 125-174 remains HPT is 12.287,77 ha. The area of HPT that scored <125 is 27.637.80 ha and therefore is possible to be converted into HP. The results can be used as an important basis for intensive forest management synergically with conservation efforts.
Mobile Computing and Ubiquitous Networking: Concepts, Technologies and Challenges.
ERIC Educational Resources Information Center
Pierre, Samuel
2001-01-01
Analyzes concepts, technologies and challenges related to mobile computing and networking. Defines basic concepts of cellular systems. Describes the evolution of wireless technologies that constitute the foundations of mobile computing and ubiquitous networking. Presents characterization and issues of mobile computing. Analyzes economical and…
... have it? For more information... Acknowledgments Concept 15 : DNA and proteins are key molecules of the cell nucleus. Learn the basic chemistry of DNA and proteins. Concept 27 : Mutations are changes in ...
What Is Phenylketonuria (PKU)?
... have it? For more information... Acknowledgments Concept 15 : DNA and proteins are key molecules of the cell nucleus. Learn the basic chemistry of DNA and proteins. Concept 27 : Mutations are changes in ...
Subversive Complicity and Basic Writing across the Curriculum
ERIC Educational Resources Information Center
Villanueva, Victor
2013-01-01
What follows is a simple assertion: time for basic writing to get out from under, a call for us to inculcate a Basic Writing Across the Curriculum. It is time yet again to move away from the concept that basic writers are in need of remedies, in part because all composition courses are in some sense remedial, and to a greater degree because the…
1991-09-01
involved in choosing hardware and so-ftware for CAI "are.the lesson objectives and the future needs of the instructor and student" (18:6-2). And...did not cover the graiTmatical errors nighlighted by the survey of subject-matter ’experts. Future research should include an expansion of, or...display any hypertext document. This tutorial covered basic English grammar concepts. Future research should address the possibilities of developing
ERIC Educational Resources Information Center
Fox, Penny
An economics project for third grade children is described and lessons for teaching basic economic concepts are provided. In the first semester, students studied basic economic concepts; in the second semester, they learned about the origin, production, and distribution of rice and poultry and how these products affect the local and state…
Advanced Concepts for Sea Control,
1977-11-01
how combinations of some improvements and finally where some of these "basic" concepts into hybrids avenues of reduced cost can be might bring about...the exact definition of the are generally accepted as the "basic" job to be done. Unfortunately, the forms and it is easy to see how hybrid - "job to be...1) first define the job then already hybrids and are really starting define alternative vehicles which might points in thei: general classes. Some do
ERIC Educational Resources Information Center
Papaphotis, Georgios; Tsaparlis, Georgios
2008-01-01
Part 2 of the findings are presented of a quantitative study (n = 125) on basic quantum chemical concepts taught at twelfth grade (age 17-18 years) in Greece. A paper-and-pencil test of fourteen questions was used that were of two kinds: five questions that tested recall of knowledge or application of algorithmic procedures (type-A questions);…
Teaching and Learning the Concept of Chemical Bonding
ERIC Educational Resources Information Center
Levy Nahum, Tami; Mamlok-Naaman, Rachel; Hofstein, Avi; Taber, Keith S.
2010-01-01
Chemical bonding is one of the key and basic concepts in chemistry. The learning of many of the concepts taught in chemistry, in both secondary schools as well as in the colleges, is dependent upon understanding fundamental ideas related to chemical bonding. Nevertheless, the concept is perceived by teachers, as well as by learners, as difficult,…
Economic Concepts for Nebraska's Junior High School Students.
ERIC Educational Resources Information Center
Myers, Dwain
This booklet identifies 14 basic economic concepts that have been selected for emphasis in junior high social studies classes in Nebraska. The booklet is accompanied by a series of related instructional units (see SO 011 416). In this booklet, the concepts are listed in a sequence from the simplest to the most complex, with concepts one through…
Oh, the Economics You'll Find in Dr. Seuss!
ERIC Educational Resources Information Center
Miller, Ben; Watts, Michael
2011-01-01
The authors list economic concepts and issues covered in the children's books published by Theodor Geisel and discuss his treatment of concepts that appear most often and that are treated in greater depth. Some concepts are sophisticated and taught as formal concepts only in college-level economics courses. Others are basic and used in economics…
Visualization: A Tool for Enhancing Students' Concept Images of Basic Object-Oriented Concepts
ERIC Educational Resources Information Center
Cetin, Ibrahim
2013-01-01
The purpose of this study was twofold: to investigate students' concept images about class, object, and their relationship and to help them enhance their learning of these notions with a visualization tool. Fifty-six second-year university students participated in the study. To investigate his/her concept images, the researcher developed a survey…
The Development of the Concept of Suicide in Children.
ERIC Educational Resources Information Center
Normand, Claude L.; Mishara, Brian L.
1992-01-01
Examined development of concept of suicide in 60 children. Found that 10 percent of first, 50 percent of third, and 95 percent of fifth graders had basic understanding of suicide. Attitudes toward suicide were neutral or negative. Concept of suicide was significantly related to concept of death and experiences with death and was also related to…
ERIC Educational Resources Information Center
Knobloch, Phillip D. Th.
2016-01-01
This article introduces a specific concept of consumer culture into the international and European discussion about new concepts and categories in comparative education. Basic meanings of consumer culture are presented in reference to consumer research, consumer culture theory, and a revisited concept of world polity. In addition to general…
Toward using games to teach fundamental computer science concepts
NASA Astrophysics Data System (ADS)
Edgington, Jeffrey Michael
Video and computer games have become an important area of study in the field of education. Games have been designed to teach mathematics, physics, raise social awareness, teach history and geography, and train soldiers in the military. Recent work has created computer games for teaching computer programming and understanding basic algorithms. We present an investigation where computer games are used to teach two fundamental computer science concepts: boolean expressions and recursion. The games are intended to teach the concepts and not how to implement them in a programming language. For this investigation, two computer games were created. One is designed to teach basic boolean expressions and operators and the other to teach fundamental concepts of recursion. We describe the design and implementation of both games. We evaluate the effectiveness of these games using before and after surveys. The surveys were designed to ascertain basic understanding, attitudes and beliefs regarding the concepts. The boolean game was evaluated with local high school students and students in a college level introductory computer science course. The recursion game was evaluated with students in a college level introductory computer science course. We present the analysis of the collected survey information for both games. This analysis shows a significant positive change in student attitude towards recursion and modest gains in student learning outcomes for both topics.
TRI Fotonovela (Latino/Hispanic novella-style introduction to TRI)
Presentation designed to introduce the basic concepts of the Toxics Release Inventory, including why TRI is an important resource for commmunities and which tool provides the easiest access to basic TRI data.
... have it? For more information... Acknowledgments Concept 15 : DNA and proteins are key molecules of the cell nucleus. Learn the basic chemistry of DNA and proteins. Concept 27 : Mutations are changes in ...
Current Concepts in the Use of Small-Particle Hyaluronic Acid.
Bertucci, Vince; Lynde, Carrie B
2015-11-01
Soft-tissue augmentation with hyaluronic acid (HA) fillers has become one of the most popular cosmetic procedures performed. HA fillers represent safe and commonly used fillers. Several different HA fillers are available. The differences lie in the manufacturing process, allowing for tailored uses. A small-particle HA with lidocaine (SP-HAL; Restylane Silk; Galderma, Uppsala, Sweden) was approved by the US Food and Drug Administration in June 2014 but has been available for many years in Canada as Restylane Fine Lines and in Europe as Restylane Vital. Relevant articles were reviewed relating to the composition, effectiveness, and safety of SP-HAL. We also discuss the author's extensive clinical experience in the use of this product in Canada. SP-HAL has demonstrated proven benefits for lip fullness, augmentation, and treatment of perioral rhytides. Although off-label in the United States, SP-HAL is also well suited for the treatment of superficial fine lines, including periorbital, forehead, marionette, and smile lines. In addition, it has also been used in the tear trough region. A novel application for SP-HAL includes use as a skinbooster with intradermal micropuncture. In this technique, small aliquots of product are injected so as to gradually rejuvenate the skin in areas such as the face and hands. Side effects of SP-HAL were generally transient and mild. The most common side effects were swelling, tenderness, bruising, pain, and redness. SP-HAL is an effective and safe HA filler with varied clinical uses.
Evaluation Research in Basic Skills with Incarcerated Adults. Technical Report No. 303.
ERIC Educational Resources Information Center
Meyer, Linda A.; And Others
To evaluate the relative effectiveness of traditional versus computer managed instruction (CMI) basic skills programs for incarcerated adults, 359 male inmates from three traditional self-paced and three PLATO/CMI programs were given pretests in the Test of Adult Basic Education (TABE) and the Tennessee Self-Concept Scale (TSCS). Following three…
Basics of Solar Heating & Hot Water Systems.
ERIC Educational Resources Information Center
American Inst. of Architects, Washington, DC.
In presenting the basics of solar heating and hot water systems, this publication is organized from the general to the specific. It begins by presenting functional and operational descriptions of solar heating and domestic hot water systems, outlining the basic concepts and terminology. This is followed by a description of solar energy utilization…
[The basic needs of the spouses of infarct patients in the acute phase of the treatment].
Takahashi, E I; da Silva, C A; Guerra, G M
1990-04-01
The purpose of this study was to identify the basic needs of the spouses of patients with myocardial infarction. The concepts of basic needs from Maslow were used as conceptual framework. The data's analysis showed the following needs affections of this population: safety, belongingness and love, esteem.
Teaching Basic Probability in Undergraduate Statistics or Management Science Courses
ERIC Educational Resources Information Center
Naidu, Jaideep T.; Sanford, John F.
2017-01-01
Standard textbooks in core Statistics and Management Science classes present various examples to introduce basic probability concepts to undergraduate business students. These include tossing of a coin, throwing a die, and examples of that nature. While these are good examples to introduce basic probability, we use improvised versions of Russian…
A Simulation for Teaching the Basic and Clinical Science of Fluid Therapy
ERIC Educational Resources Information Center
Rawson, Richard E.; Dispensa, Marilyn E.; Goldstein, Richard E.; Nicholson, Kimberley W.; Vidal, Noni Korf
2009-01-01
The course "Management of Fluid and Electrolyte Disorders" is an applied physiology course taught using lectures and paper-based cases. The course approaches fluid therapy from both basic science and clinical perspectives. While paper cases provide a basis for application of basic science concepts, they lack key components of genuine clinical…
Nisticò, S; Ehrlich, J; Gliozzi, M; Maiuolo, J; Del Duca, E; Muscoli, C; Mollace, V
2015-01-01
Photoageing represents the addition of extrinsic chronic ultraviolet radiation-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. In this study, we evaluated the effect of 38% BPF, a highly concentrated extract of the bergamot fruit (Citrus bergamia) on UVB-induced photoageing by examining inflammatory cytokine expression, telomere length/telomerase alterations and cellular viability in human immortalized HaCaT keratinocytes. Our results suggest that 38% BPF protects HaCaT cells against UVB-induced oxidative stress and markers of photoageing in a dose-dependent manner and could be a useful supplement in skin care products. Together with antioxidant properties, BPF, a highly concentrated extract of the bergamot fruit, appears to modulate basic cellular signal transduction pathways leading to anti-proliferative, anti-aging and immune modulating responses.
Workplace Math II: Math Works!
ERIC Educational Resources Information Center
Wilson, Nancy; Goschen, Claire
This learning module, a continuation of the math I module, provides review and practice of the concepts explored in the earlier module at an intermediate level involving workplace problems. The following concepts are covered: instruction in performing basic computations, using general numerical concepts such as whole numbers, fractions, decimals,…
A new concept for creating the basic map
NASA Astrophysics Data System (ADS)
Parzyński, Zenon
2014-12-01
A lot of changes have been made to the legislative regulations associated with geodesy during the implementation of the INSPIRE Directive in Poland (amongst others, the structure of databases). There have also been great changes concerning the basic map and the method of its creation and updating. A new concept for creating the basic map is presented in this article Dokonaliśmy wielu zmian w prawnych regulacjach dotyczących geodezji w trakcie implementacji Dyrektywy INSPIRE w Polsce (m.in. struktury baz danych). Bardzo duże zmiany objęły mapę zasadniczą i procedury jej tworzenia i uaktualniania. W artykule jest zaprezentowana nowa koncepcja tworzenia mapy zasadniczej.
Clinical Correlations as a Tool in Basic Science Medical Education
Klement, Brenda J.; Paulsen, Douglas F.; Wineski, Lawrence E.
2016-01-01
Clinical correlations are tools to assist students in associating basic science concepts with a medical application or disease. There are many forms of clinical correlations and many ways to use them in the classroom. Five types of clinical correlations that may be embedded within basic science courses have been identified and described. (1) Correlated examples consist of superficial clinical information or stories accompanying basic science concepts to make the information more interesting and relevant. (2) Interactive learning and demonstrations provide hands-on experiences or the demonstration of a clinical topic. (3) Specialized workshops have an application-based focus, are more specialized than typical laboratory sessions, and range in complexity from basic to advanced. (4) Small-group activities require groups of students, guided by faculty, to solve simple problems that relate basic science information to clinical topics. (5) Course-centered problem solving is a more advanced correlation activity than the others and focuses on recognition and treatment of clinical problems to promote clinical reasoning skills. Diverse teaching activities are used in basic science medical education, and those that include clinical relevance promote interest, communication, and collaboration, enhance knowledge retention, and help develop clinical reasoning skills. PMID:29349328
Infrastructure Task Force Sustainable Infrastructure Goals and Concepts Document
This document outlines the concepts of appropriate infrastructure and sustainable management entities to guide the coordinated federal efforts to achieve greater sustainable access to safe drinking water and basic sanitation.
NASA Astrophysics Data System (ADS)
Cui, Z. L.; Ye, Y. L.; Ma, W. Q.; Chen, X. P.; Zhang, F. S.
2013-10-01
Although the concept of producing higher yields with reduced greenhouse gas (GHG) emissions is a goal that attracts increasing public and scientific attention, the tradeoff between crop productivity and GHG emissions in intensive agricultural production is not well understood. In this study, we investigated 33 sites of on-farm experiments to evaluate the tradeoff between grain yield and GHG emissions using two systems (conventional practice, CP; high-yielding systems, HY) of intensive irrigation wheat (Triticum aestivum L.) in China. Furthermore, we discussed the potential to produce higher yields with lower GHG emissions based on a survey of 2938 farmers. However, in both the HY and CP systems, wheat grain yield response to GHG emissions fit a linear-plateau model, whereas the curve for grain yield from the HY system was always higher than that from the CP system. Compared to the CP system, grain yield was 44% (2.6 Mg ha-1) higher in the HY system, while GHG emissions increased by only 2.5%, and GHG emission intensity was reduced by 29%. The current intensive irrigation wheat system with farmers' practice had a median yield and maximum GHG emission rate of 6.05 Mg ha-1 and 4783 kg CO2 eq ha-1, respectively; however, this system can be transformed to maintain yields while reducing GHG emissions by 40% (5.96 Mg ha-1, and 2890 kg CO2 eq ha-1). Further, the HY system was found to increase grain yield by 41% with a simultaneous reduction in GHG emissions by 38% (8.55 Mg ha-1, and 2961 kg CO2 eq ha-1, respectively). In the future, we suggest moving the tradeoff relationships and calculations from grain yield and GHG emissions, to new measures of productivity and environmental protection using innovative management technologies. This shift in focus is critical to achieve food and environmental security.
Baboolal, Thomas G; Mastbergen, Simon C; Jones, Elena; Calder, Stuart J; Lafeber, Floris P J G; McGonagle, Dennis
2016-05-01
Knee joint distraction (KJD) is a novel, but poorly understood, treatment for osteoarthritis (OA) associated with remarkable 'spontaneous' cartilage repair in which resident synovial fluid (SF) multipotential mesenchymal stromal cells (MSCs) may play a role. We hypothesised that SF hyaluronic acid (HA) inhibited the initial interaction between MSCs and cartilage, a key first step to integration, and postulate that KJD environment favoured MSC/cartilage interactions. Attachment of dual-labelled SF-MSCs were assessed in a novel in vitro human cartilage model using OA and rheumatoid arthritic (RA) SF. SF was digested with hyaluronidase (hyase) and its effect on adhesion was observed using confocal microscopy. MRI and microscopy were used to image autologous dual-labelled MSCs in an in vivo canine model of KJD. SF-HA was investigated using gel electrophoresis and densitometry. Osteoarthritic-synovial fluid (OA-SF) and purified high molecular weight (MW) HA inhibited SF-MSC adhesion to plastic, while hyase treatment of OA-SF but not RA-SF significantly increased MSC adhesion to cartilage (3.7-fold, p<0.05) These differences were linked to the SF mediated HA-coat which was larger in OA-SF than in RA-SF. OA-SF contained >9 MDa HA and this correlated with increases in adhesion (r=0.880). In the canine KJD model, MSC adhesion to cartilage was evident and also dependent on HA MW. These findings highlight an unappreciated role of SF-HA on MSC interactions and provide proof of concept that endogenous SF-MSCs are capable of adhering to cartilage in a favourable biochemical and biomechanical environment in OA distracted joints, offering novel one-stage strategies towards joint repair. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
The Efficacy of Multimedia Modules for Teaching Basic Literacy-Related Concepts
ERIC Educational Resources Information Center
Sayeski, Kristin L.; Kennedy, Michael J.; de Irala, Sandra; Clinton, Elias; Hamel, Melissa; Thomas, Kristen
2015-01-01
Researchers have found that teacher preparation programs are not universally preparing teacher candidates in concepts associated with the alphabetic principle. Yet, the majority of students with reading disabilities or who struggle with beginning reading have difficulty with phonology and concepts associated with the alphabetic principle. The…
Unified Technical Concepts. Application Modules Volume II.
ERIC Educational Resources Information Center
Center for Occupational Research and Development, Inc., Waco, TX.
Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the second of two volumes, consists of 45 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force…
How to Teach Procedures, Problem Solving, and Concepts in Microbial Genetics
ERIC Educational Resources Information Center
Bainbridge, Brian W.
1977-01-01
Flow-diagrams, algorithms, decision logic tables, and concept maps are presented in detail as methods for teaching practical procedures, problem solving, and basic concepts in microbial genetics. It is suggested that the flexible use of these methods should lead to an improved understanding of microbial genetics. (Author/MA)
Some Basic Concepts of Wave-Particle Interactions in Collisionless Plasmas
NASA Technical Reports Server (NTRS)
Lakhina, Gurbax S.; Tsurutani, Bruce T.
1997-01-01
The physical concepts of wave-particle interactions in a collisionless plasma are developed from first principles. Using the Lorentz force, starting with the concepts of gyromotion, particle mirroring and the loss-cone, normal and anomalous cyclotron resonant interactions, pitch-angle scattering, and cross-field diffusion are developed.
Yang, Qing; Qiu, Lihong; Yi, Chenggang; Xue, Ping; Yu, Zhou; Ma, Xianjie; Su, Yingjun; Guo, Shuzhong
2017-06-01
Hyaluronic acid (HA) filler injection is widely used for soft-tissue augmentation. Complications associated with HA filling are not uncommon; however, HA-induced alopecia is a rarely reported complication that could result in severe secondary psychological trauma. The etiology, clinical traits, treatment strategies, outcomes, and possible reversibility of HA-induced alopecia have not been characterized. Here, we report a case in which bilateral temple injections of 6.5 mL of HA led to persistent pain over the left scalp for several days. Although the pain was relieved at day 9 after 600 U of hyaluronidase were injected in the left temple, the patient developed localized alopecia at the left temporoparietal region with central skin necrosis at day 15. After topical applications of recombinant bovine basic fibroblast growth factor gel and 2% minoxidil spay, the necrotic skin wound was healed at day 42. Hair regrowth and normal hair density were restored at day 74. Analyses of Doppler ultrasound examinations and histopathology of the skin biopsy suggested that mild ischemia of the left temporoparietal region led to reversible alopecia, while the permanent hair loss in the left parietal area was associated with severe skin ischemia. Therefore, the key to treatment would be to focus on the effective correction of severe ischemia-induced skin necrosis to prevent permanent hair loss. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Pacca, S; Moreira, J R
2011-11-15
Biofuels are considered as a carbon neutral alternative to hydrocarbons in the transport sector and this approach has triggered concerns about the impact the production of biofuels might have on land usage. Another option that might also lead to reduced emissions in the transport sector is electricity based on renewable energy sources such as biomass. Below, we assess the benefits and drawbacks of the joint production of ethanol and electricity in a sugar cane based refinery, and the use of both energy forms in privately owned automobiles. In this analysis, we have considered technology for energy production that is currently available and cost competitive. The results show that the amount of land that is required to power our current automobile use needs is less than what is typically stated. According to our results that are based on 2010 values, 2 million ha of land are sufficient to power the Brazilian automobile fleet, 25 million ha are enough to satisfy the needs of the U.S. fleet, and 67 million ha are sufficient to cover the global autofuel requirements. When minor efficiency gains are considered, 19 million ha will be enough to satisfy the fuel needs of the U.S. fleet in 2030, whereas land required to supply the Brazilian and global fleet remain basically unchanged. Our analysis shows that the harvested energy density of sugar cane is 306 GJ/ha/yr, which is 1.7 times the value usually reported in the literature for biofuels. As a result, taking advantage of the primary energy potential of sugar cane, only 4% of the world's available cropland area would be sufficient to produce fuels that would power the global car fleet.
Sustainable Rural Energy: Traditional Water Wheels in Padang (PWW) Indonesia
NASA Astrophysics Data System (ADS)
Ibrahim, Gusri Akhyar; Haron, Che Hassan Che; Azhari, Che Husna
2010-06-01
Renewable and sustainable energy is increasingly gaining interest in current research circles due to the debates on renewable energy resources. It is essential for scientists and researchers to search for solutions in renewable energy resources, with effective technologies, and low cost in operation and maintenance. Hydro resources can be considered a potential renewable energy resource. The traditional water wheel with simple construction coupled with a basic concept of technology can be utilised as a renewable and sustainable rural energy system. This paper discusses the case of the water wheel as a renewable energy system employed in Padang, Indonesia. The Padang water wheel is constructed from hardwood material with a diameter of 300 cm and width of 40 cm. It is built on a river using water flow to generate the movement of the wheel. The water wheel application in the area showed that it is suitable to be utilised to elevate and distribute water to rice fields located at a higher level than the water level of the river. The water wheel capacity is about 100-120 liters/min. It could continuously irrigate ±5 ha. of the rice fields. One of the advantages of this water wheel type is to function as a green technology concept promising no negative effect on the environment. The traditional water wheel has also a big economic impact on the rural economy, increasing the productivity of the rice fields. The people of Padang live in a water landscape encompassing the water wheel as an ubiquitous part of their lives, hence they relate to it and the technology of fabrication as well as the utilisation, making it an amenable and effective technology, finding relevance in the modern world.
A Small-Scale Low-Cost Gas Chromatograph
ERIC Educational Resources Information Center
Gros, Natasa; Vrtacnik, Margareta
2005-01-01
The design and application of a small-scale portable gas chromatograph for learning of the basic concepts of chromatography is described. The apparatus consists of two basic separable units, which includes a chromatographic unit and an electronic unit.
1978-01-01
South Carolina fo 9*10=0 ~c cmd me, hA. lUU~h~hum~gd.~ JANUARY 1978 85 01 11 084 S ~~ . . . . . . . . . . . . . . FEASIBILITY REPORT REVIEW OF REPORT...ADOPTED JANUARY 28, 1958 2 ENVIRONMENTAL ASSESSMENT . . °.. . . . . . . . . . . .. . .. -" . , .". * * . . . . . . . .. -~ . . . -. REVIEW OF REPORTS... review . As a result of this review , it was judged that some of the basic assumptions presented in the draft report were no longer applicable and that
RLE (Research Laboratory of Electronics) Progress Report Number 129.
1987-01-01
8217," ’,/’.’t MICROCOP ,"Y RESOLUTION TEST C-’HA"-/’%’.’."."% "-’- -" "."o -- - -" " OI FILE COPYAJ MASSACHUSETTS INSTITUTE OF EHOGYD The RESEARCH LABORATORY of...Intercalation Compound Structures and Transitions .................................. 59 10.0 Semiconductor Surface Studies...understanding of the HEMT, which is the basic block in building surface superlattices on III-V compound materials, our device structure has been simu
ERIC Educational Resources Information Center
Umar, Yunusa
2014-01-01
A simple and effective hands-on classroom activity designed to illustrate basic polymer concepts is presented. In this activity, students build primary structures of homopolymers and different arrangements of monomers in copolymer using paper clips as monomers. The activity supports formation of a basic understanding of polymer structures,…
BASIC MATHEMATICS I FOR THE SECONDARY SCHOOLS.
ERIC Educational Resources Information Center
MCCARTHY, CHARLES T.; AND OTHERS
THE COURSE IS GEARED TO MEET THE NEEDS OF STUDENTS ENTERING SENIOR HIGH SCHOOL WITH A MATHEMATICS ACHIEVEMENT LEVEL BELOW SIXTH GRADE. SINCE TWO PRINCIPAL CAUSES OF SERIOUS DEFICIENCIES IN ARITHMETIC ARE A LACK OF UNDERSTANDING OF THE DECIMAL SYSTEM OF NOTATION AND A LACK OF KNOWLEDGE OF THE BASIC FUNDAMENTALS OF ARITHMETIC, BASIC CONCEPTS MUST BE…
ERIC Educational Resources Information Center
Smith, Regina O.
2014-01-01
Research into the best practices for basic skills education, national bridge programs, the new GED® assessment, and accelerated developmental education indicated that contextualized instruction was most effective when preparing adult literacy students for college and work. Nevertheless, "remedial pedagogy" with a sole focus on the…
WORKING WITH STUDENTS INSIDE AND OUTSIDE THE CLASSROOM IN ADULT BASIC EDUCATION PROGRAMS.
ERIC Educational Resources Information Center
BRAZZIEL, WILLIAM F.
TECHNICAL EDUCATION OF THE ADULT HARD-CORE UNEMPLOYED OFTEN FAILS BECAUSE OF PERSONAL PROBLEMS AND BASIC EDUCATION AND CULTURAL LACKS. A BROAD CONCEPT OF EDUCATION IS ESSENTIAL TO PROGRAMS FOR DEVELOPMENT OF TECHNICAL SKILLS. A COLLEGE PROJECT DESIGNED TO MEET THESE REQUIREMENTS IS PRESENTED. A COMBINATION OF BASIC AND TECHNICAL EDUCATION WITH THE…
Nondestructive Testing Eddy Current Basic Principles RQA/M1-5330.12 (V-I).
ERIC Educational Resources Information Center
National Aeronautics and Space Administration, Huntsville, AL. George C. Marshall Space Flight Center.
As one in the series of programmed instruction handbooks, prepared by the U.S. space program, home study material is presented in this volume concerning familiarization and orientation on basic eddy current principles. The subject is presented under the following headings: Basic Eddy Current Concepts, Eddy Current Generation and Distribution,…
ERIC Educational Resources Information Center
Quann, Steve; Satin, Diana
This textbook leads high-beginning and intermediate English-as-a-Second-Language (ESL) students through cooperative computer-based activities that combine language learning with training in basic computer skills and word processing. Each unit concentrates on a basic concept of word processing while also focusing on a grammar topic. Skills are…
A Simple Case Study of a Grid Performance System
NASA Technical Reports Server (NTRS)
Aydt, Ruth; Gunter, Dan; Quesnel, Darcy; Smith, Warren; Taylor, Valerie; Biegel, Bryan (Technical Monitor)
2001-01-01
This document presents a simple case study of a Grid performance system based on the Grid Monitoring Architecture (GMA) being developed by the Grid Forum Performance Working Group. It describes how the various system components would interact for a very basic monitoring scenario, and is intended to introduce people to the terminology and concepts presented in greater detail in other Working Group documents. We believe that by focusing on the simple case first, working group members can familiarize themselves with terminology and concepts, and productively join in the ongoing discussions of the group. In addition, prototype implementations of this basic scenario can be built to explore the feasibility of the proposed architecture and to expose possible shortcomings. Once the simple case is understood and agreed upon, complexities can be added incrementally as warranted by cases not addressed in the most basic implementation described here. Following the basic performance monitoring scenario discussion, unresolved issues are introduced for future discussion.
Zhao, Yue; Liu, Zhiyong; Liu, Chenfeng; Hu, Zhipeng
2017-01-01
Microalgae are considered to be a potential major biomass feedstock for biofuel due to their high lipid content. However, no correlation equations as a function of initial nitrogen concentration for lipid accumulation have been developed for simplicity to predict lipid production and optimize the lipid production process. In this study, a lipid accumulation model was developed with simple parameters based on the assumption protein synthesis shift to lipid synthesis by a linear function of nitrogen quota. The model predictions fitted well for the growth, lipid content, and nitrogen consumption of Coelastrum sp. HA-1 under various initial nitrogen concentrations. Then the model was applied successfully in Chlorella sorokiniana to predict the lipid content with different light intensities. The quantitative relationship between initial nitrogen concentrations and the final lipid content with sensitivity analysis of the model were also discussed. Based on the model results, the conversion efficiency from protein synthesis to lipid synthesis is higher and higher in microalgae metabolism process as nitrogen decreases; however, the carbohydrate composition content remains basically unchanged neither in HA-1 nor in C. sorokiniana. PMID:28194424
Brain Representations of Basic Physics Concepts
NASA Astrophysics Data System (ADS)
Just, Marcel Adam
2017-09-01
The findings concerning physics concepts build on the remarkable new ability to determine the neural signature (or activation pattern) corresponding to an individual concept using fMRI brain imaging. Moreover, the neural signatures can be decomposed into meaningful underlying dimensions, identifying the individual, interpretable components of the neural representation of a concept. The investigation of physics concepts representations reveals how relatively recent physics concepts (formalized only in the last few centuries) are stored in the millenia-old information system of the human brain.
Faculty Performance on the Genomic Nursing Concept Inventory.
Read, Catherine Y; Ward, Linda D
2016-01-01
To use the newly developed Genomic Nursing Concept Inventory (GNCI) to evaluate faculty understanding of foundational genomic concepts, explore relative areas of strength and weakness, and compare the results with those of a student sample. An anonymous online survey instrument consisting of demographic or background items and the 31 multiple-choice questions that make up the GNCI was completed by 495 nursing faculty from across the United States in the fall of 2014. Total GNCI score and scores on four subcategories (genome basics, mutations, inheritance, genomic health) were calculated. Relationships between demographic or background variables and total GNCI score were explored. The mean score on the GNCI was 14.93 (SD = 5.31), or 48% correct; topical category scores were highest on the inheritance and genomic health items (59% and 58% correct, respectively), moderate on the mutations items (54% correct), and lowest on the genome basics items (33% correct). These results are strikingly similar to those of a recent study of nursing students. Factors associated with a higher total score on the GNCI included higher self-rated proficiency with genetic/genomic content, having a doctoral degree, having taken a genetics course for academic credit or continuing education, and having taught either a stand-alone genetic/genomic course or lecture content as part of nursing or related course. Self-rated proficiency with genetic/genomic content was fair or poor (70%), with only 7% rating their proficiency as very good or excellent. Faculty knowledge of foundational genomic concepts is similar to that of the students they teach and weakest in the areas related to basic science information. Genomics is increasingly relevant in all areas of clinical nursing practice, and the faculty charged with educating the next generation of nurses must understand foundational concepts. Faculty need to be proactive in seeking out relevant educational programs that include basic genetic/genomic concepts. © 2015 Sigma Theta Tau International.
Basic Concepts and Principles of Marketing.
ERIC Educational Resources Information Center
Beder, Hal
1986-01-01
Presents an overview of marketing concepts and principles. These include (1) organizational objectives, (2) exchange, (3) value, (4) market segmentation, (5) market position, (6) consumer analysis, (7) product, (8) promotion, (9) place, and (10) price. (CH)
ERIC Educational Resources Information Center
Schon, Isabel
1992-01-01
A guide for teachers and librarians covering over 50 Spanish-language books that introduce children to various animals; the world around them; colors, shapes, and numbers; the universe; basic science concepts; and the process of conception, pregnancy, and birth. (MDH)
Improving basic math skills through integrated dynamic representation strategies.
González-Castro, Paloma; Cueli, Marisol; Cabeza, Lourdes; Álvarez-García, David; Rodríguez, Celestino
2014-01-01
In this paper, we analyze the effectiveness of the Integrated Dynamic Representation strategy (IDR) to develop basic math skills. The study involved 72 students, aged between 6 and 8 years. We compared the development of informal basic skills (numbers, comparison, informal calculation, and informal concepts) and formal (conventionalisms, number facts, formal calculus, and formal concepts) in an experimental group (n = 35) where we applied the IDR strategy and in a Control group (n = 37) in order to identify the impact of the procedure. The experimental group improved significantly in all variables except for number facts and formal calculus. It can therefore be concluded that IDR favors the development of the skills more closely related to applied mathematics than those related to automatic mathematics and mental arithmetic.
Theory of buckling and post-buckling behavior of elastic structures
NASA Technical Reports Server (NTRS)
Budiansky, B.
1974-01-01
The present paper provides a unified, general presentation of the basic theory of the buckling and post-buckling behavior of elastic structures in a form suitable for application to a wide variety of special problems. The notation of functional analysis is used for this purpose. Before the general analysis, simple conceptual models are used to elucidate the basic concepts of bifurcation buckling, snap buckling, imperfection sensitivity, load-shortening relations, and stability. The energy approach, the virtual-work approach, and mode interaction are discussed. The derivations and results are applicable to continua and finite-dimensional systems. The virtual-work and energy approaches are given separate treatments, but their equivalence is made explicit. The basic concepts of stability occupy a secondary position in the present approach.
Identifying Opportunities for Vertical Integration of Biochemistry and Clinical Medicine.
Wendelberger, Karen J.; Burke, Rebecca; Haas, Arthur L.; Harenwattananon, Marisa; Simpson, Deborah
1998-01-01
Objectives: Retention of basic science knowledge, as judged by National Board of Medical Examiners' (NBME) data, suffers due to lack of apparent relevance and isolation of instruction from clinical application, especially in biochemistry. However, the literature reveals no systematic process for identifying key biochemical concepts and associated clinical conditions. This study systematically identified difficult biochemical concepts and their common clinical conditions as a critical step towards enhancing relevance and retention of biochemistry.Methods: A multi-step/ multiple stakeholder process was used to: (1) identify important biochemistry concepts; (2) determine students' perceptions of concept difficulty; (3) assess biochemistry faculty, student, and clinical teaching scholars' perceived relevance of identified concepts; and (4) identify associated common clinical conditions for relevant and difficult concepts. Surveys and a modified Delphi process were used to gather data, subsequently analyzed using SPSS for Windows.Results: Sixteen key biochemical concepts were identified. Second year medical students rated 14/16 concepts as extremely difficult while fourth year students rated nine concepts as moderately to extremely difficult. On average, each teaching scholar generated common clinical conditions for 6.2 of the 16 concepts, yielding a set of seven critical concepts and associated clinical conditions.Conclusions: Key stakeholders in the instructional process struggle to identify biochemistry concepts that are critical, difficult to learn and associated with common clinical conditions. However, through a systematic process beginning with identification of concepts and associated clinical conditions, relevance of basic science instruction can be enhanced.
ERIC Educational Resources Information Center
Boiteau, Denise; Stansfield, David
This document describes mathematical programs on the basic concepts of algebra produced by Louisiana Public Broadcasting. Programs included are: (1) "Inverse Operations"; (2) "The Order of Operations"; (3) "Basic Properties" (addition and multiplication of numbers and variables); (4) "The Positive and Negative…
Unified Technical Concepts. Application Modules Volume I.
ERIC Educational Resources Information Center
Center for Occupational Research and Development, Inc., Waco, TX.
Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the first of two volumes, consists of 56 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force, work,…
ERIC Educational Resources Information Center
Pierce, W. David; Sydie, R. A.; Stratkotter, Rainer
2003-01-01
Male and female participants (N = 274) made judgments about the social concepts of "feminist," "man," and "woman" on 63 semantic differential items. Factor analysis identified three basic dimensions termed evaluative, potency, and activity as well as two secondary factors called expressiveness and sexuality. Results for the evaluative dimension…
A Demonstration of the Analysis of Variance Using Physical Movement and Space
ERIC Educational Resources Information Center
Owen, William J.; Siakaluk, Paul D.
2011-01-01
Classroom demonstrations help students better understand challenging concepts. This article introduces an activity that demonstrates the basic concepts involved in analysis of variance (ANOVA). Students who physically participated in the activity had a better understanding of ANOVA concepts (i.e., higher scores on an exam question answered 2…
Teaching Conceptually Oriented Social Science Education Programs in the Elementary School.
ERIC Educational Resources Information Center
Mahlios, Marc C.
Approaches to elementary social studies education that focus on concept and inquiry learning are outlined. The basic goal of the teacher in concept teaching is to aid the student in developing relationships among factual learning, conceptualization, and personal behavior. Learning activities should focus on the process concept (i.e., one that is…
The Conservation of Energy Concept in Ninth Grade General Science, Final Report.
ERIC Educational Resources Information Center
Shockley, William; And Others
Discussed is an instructional approach, "concept-distillation," which involves experiences, games, and puzzles that have the "distilled essence" of the basic concepts of the physical sciences. This approach is designed to impart a vivid and dramatic meaning and structure of the sciences for transfer in scientific thinking. The…
Plastic Solar Cells: A Multidisciplinary Field to Construct Chemical Concepts from Current Research
ERIC Educational Resources Information Center
Gomez, Rafael; Segura, Jose L.
2007-01-01
Examples of plastic solar-cell technology to illustrate core concepts in chemistry are presented. The principles of operations of a plastic solar cell could be used to introduce key concepts, which are fundamentally important to understand photosynthesis and the basic process that govern most novel optoelectronic devices.
ERIC Educational Resources Information Center
Abate, Marie A.; Meyer-Stout, Paula J.; Stamatakis, Mary K.; Gannett, Peter M.; Dunsworth, Teresa S.; Nardi, Anne H.
2000-01-01
Describes development and evaluation of eight computerized problem-based learning (PBL) cases in medicinal chemistry and pharmaceutics concepts. Case versions either incorporated concept maps emphasizing key ideas or did not. Student performance on quizzes did not differ between the different case versions and was similar to that of students who…
Cor, M Ken
Interpreting results from quantitative research can be difficult when measures of concepts are constructed poorly, something that can limit measurement validity. Social science steps for defining concepts, guidelines for limiting construct-irrelevant variance when writing self-report questions, and techniques for conducting basic item analysis are reviewed to inform the design of instruments to measure social science concepts in pharmacy education research. Based on a review of the literature, four main recommendations emerge: These include: (1) employ a systematic process of conceptualization to derive nominal definitions; (2) write exact and detailed operational definitions for each concept, (3) when creating self-report questionnaires, write statements and select scales to avoid introducing construct-irrelevant variance (CIV); and (4) use basic item analysis results to inform instrument revision. Employing recommendations that emerge from this review will strengthen arguments to support measurement validity which in turn will support the defensibility of study finding interpretations. An example from pharmacy education research is used to contextualize the concepts introduced. Copyright © 2017 Elsevier Inc. All rights reserved.
Costa, Sebastiano; Gugliandolo, Maria C; Barberis, Nadia; Larcan, Rosalba
2016-02-01
Relatively few studies have examined the relationship between conception of God and psychological outcomes in a self-determination theory (SDT) framework. The aim of this study was to examine the role of basic psychological needs as a mediator of the association between conception of God and psychological outcomes. In a sample of 210 religious young adults, we found that the concept of a controlling God was positively associated with feelings of need frustration and depression, whilst the concept of an autonomy-supporting God was positively associated with feelings of need satisfaction and vitality. In turn, need satisfaction promoted feelings of vitality, whereas need frustration led to feelings of depression. The satisfaction of needs was a full mediator of the relationship between autonomy-supporting God and vitality, whilst the frustration of needs was a full mediator of the relationship between controlling God and depression. These findings are discussed in terms of SDT. We also discuss how future research may further increase our understanding of the dynamics involved in concepts of God and psychological outcomes.
Aklıbaşında, Meliha; Bulut, Yahya
2014-09-01
The use and utilization areas of geographic information system (GIS) increase every day due to both enabling easiness in storing, updating, grouping, analyzing, correlating, and mapping of data about evaluation factors in planning studies and having quite low error margin depending on the accuracy of data stored. In fact, GIS is also used both in visualization and in various analyses in planning tourism terrains. In this study, the effectiveness of GIS on holistic evaluation of natural and cultural resources in planning tourism terrains was analyzed. Natural and cultural resources in Kayseri Yahyalı were quantified by using ArcGIS 9.3 software from GIS software; data were analyzed and potential tourism and recreation terrains, level of suitability, and rate of coverage were determined. As a result of the analyses, it was determined that 11.847 ha area (6,53%) was quite suitable for such kind of activities, 103.010 ha (56,77%) was suitable, 39.278 ha (21,65%) was less suitable, and 27.314 ha area (15,05%) was not suitable. In the next stage, landscape properties which are suitable for tourism and recreation were evaluated and landscape types were classified in the sense of their tourist attraction. It was determined that the water resources and valley landscapes were the basic sources of the tourism and recreation activities of Yahyalı, and it was determined that the landscape of the forest and mountain was important for variety of the tourism and recreation activities of Yahyalı.
Aminopropyl-Silica Hybrid Particles as Supports for Humic Acids Immobilization.
Sándor, Mónika; Nistor, Cristina Lavinia; Szalontai, Gábor; Stoica, Rusandica; Nicolae, Cristian Andi; Alexandrescu, Elvira; Fazakas, József; Oancea, Florin; Donescu, Dan
2016-01-08
A series of aminopropyl-functionalized silica nanoparticles were prepared through a basic two step sol-gel process in water. Prior to being aminopropyl-functionalized, silica particles with an average diameter of 549 nm were prepared from tetraethyl orthosilicate (TEOS), using a Stöber method. In a second step, aminopropyl-silica particles were prepared by silanization with 3-aminopropyltriethoxysilane (APTES), added drop by drop to the sol-gel mixture. The synthesized amino-functionalized silica particles are intended to be used as supports for immobilization of humic acids (HA), through electrostatic bonds. Furthermore, by inserting beside APTES, unhydrolysable mono-, di- or trifunctional alkylsilanes (methyltriethoxy silane (MeTES), trimethylethoxysilane (Me₃ES), diethoxydimethylsilane (Me₂DES) and 1,2-bis(triethoxysilyl)ethane (BETES)) onto silica particles surface, the spacing of the free amino groups was intended in order to facilitate their interaction with HA large molecules. Two sorts of HA were used for evaluating the immobilization capacity of the novel aminosilane supports. The results proved the efficient functionalization of silica nanoparticles with amino groups and showed that the immobilization of the two tested types of humic acid substances was well achieved for all the TEOS/APTES = 20/1 (molar ratio) silica hybrids having or not having the amino functions spaced by alkyl groups. It was shown that the density of aminopropyl functions is low enough at this low APTES fraction and do not require a further spacing by alkyl groups. Moreover, all the hybrids having negative zeta potential values exhibited low interaction with HA molecules.
Ras Family GTPases Control Growth of Astrocyte Processes
Kalman, Daniel; Gomperts, Stephen N.; Hardy, Stephen; Kitamura, Marina; Bishop, J. Michael
1999-01-01
Astrocytes in neuron-free cultures typically lack processes, although they are highly process-bearing in vivo. We show that basic fibroblast growth factor (bFGF) induces cultured astrocytes to grow processes and that Ras family GTPases mediate these morphological changes. Activated alleles of rac1 and rhoA blocked and reversed bFGF effects when introduced into astrocytes in dissociated culture and in brain slices using recombinant adenoviruses. By contrast, dominant negative (DN) alleles of both GTPases mimicked bFGF effects. A DN allele of Ha-ras blocked bFGF effects but not those of Rac1-DN or RhoA-DN. Our results show that bFGF acting through c-Ha-Ras inhibits endogenous Rac1 and RhoA GTPases thereby triggering astrocyte process growth, and they provide evidence for the regulation of this cascade in vivo by a yet undetermined neuron-derived factor. PMID:10233170
ERIC Educational Resources Information Center
Grover, Anita; Lam, Tai Ning; Hunt, C. Anthony
2008-01-01
We present a simulation tool to aid the study of basic pharmacology principles. By taking advantage of the properties of agent-based modeling, the tool facilitates taking a mechanistic approach to learning basic concepts, in contrast to the traditional empirical methods. Pharmacodynamics is a particular aspect of pharmacology that can benefit from…
ERIC Educational Resources Information Center
Buckrop, Jacquelyn J.
At Ball State University in Indiana, the basic course (COMM 210) focuses communication concepts and skills with the goals of helping students understand basic communication principles, providing them with the opportunity to improve their communication skills, and enhancing their awareness of communication's role in culture. Special emphasis is…
NASA Astrophysics Data System (ADS)
Wibowo, F. C.; Suhandi, A.; Rusdiana, D.; Darman, D. R.; Ruhiat, Y.; Denny, Y. R.; Suherman; Fatah, A.
2016-08-01
A Study area in physics learning is purposeful on the effects of various types of learning interventions to help students construct the basic of scientific conception about physics. Microscopic Virtual Media (MVM) are applications for physics learning to support powerful modelling microscopic involving physics concepts and processes. In this study groups (experimental) of 18±20 years old, students were studied to determine the role of MVM in the development of functional understanding of the concepts of thermal expansion in heat transfer. The experimental group used MVM in learning process. The results show that students who learned with virtual media exhibited significantly higher scores in the research tasks. Our findings proved that the MVM may be used as an alternative instructional tool, in order to help students to confront and constructed their basic of scientific conception and developed their understanding.
The unit field sanitation team: a square peg in a round hole.
Bosetti, Timothy; Bridges, Davin
2009-01-01
Basic field sanitation and hygiene is a lost art in today's modern Army. Today, more than ever, there is a need for the unit field sanitation team (FST) to serve as advisors to unit commanders in the area of basic field sanitation and hygiene. Soldiers should know how to construct field latrines, construct waste disposal devices, conduct pest management and control activities, disinfect field water supplies, and practice personal hygiene under field conditions. The current unit FST concept is centered on company-sized formations operating in open terrain. This concept does not support current operations, transformed formations, rapidly changing doctrine, and the expeditionary nature of the Army. This article does not present a new concept, but rather a new look at an existing concept and practice based upon the lessons-learned and after-action reports from the Global War on Terrorism to support the Army in transformation during an era of persistent conflict.
Taylor, Kirsten I; Devereux, Barry J; Acres, Kadia; Randall, Billi; Tyler, Lorraine K
2012-03-01
Conceptual representations are at the heart of our mental lives, involved in every aspect of cognitive functioning. Despite their centrality, a long-standing debate persists as to how the meanings of concepts are represented and processed. Many accounts agree that the meanings of concrete concepts are represented by their individual features, but disagree about the importance of different feature-based variables: some views stress the importance of the information carried by distinctive features in conceptual processing, others the features which are shared over many concepts, and still others the extent to which features co-occur. We suggest that previously disparate theoretical positions and experimental findings can be unified by an account which claims that task demands determine how concepts are processed in addition to the effects of feature distinctiveness and co-occurrence. We tested these predictions in a basic-level naming task which relies on distinctive feature information (Experiment 1) and a domain decision task which relies on shared feature information (Experiment 2). Both used large-scale regression designs with the same visual objects, and mixed-effects models incorporating participant, session, stimulus-related and feature statistic variables to model the performance. We found that concepts with relatively more distinctive and more highly correlated distinctive relative to shared features facilitated basic-level naming latencies, while concepts with relatively more shared and more highly correlated shared relative to distinctive features speeded domain decisions. These findings demonstrate that the feature statistics of distinctiveness (shared vs. distinctive) and correlational strength, as well as the task demands, determine how concept meaning is processed in the conceptual system. Copyright © 2011 Elsevier B.V. All rights reserved.
The AAPM/RSNA physics tutorial for residents. Basic physics of MR imaging: an introduction.
Hendrick, R E
1994-07-01
This article provides an introduction to the basic physical principles of magnetic resonance (MR) imaging. Essential basic concepts such as nuclear magnetism, tissue magnetization, precession, excitation, and tissue relaxation properties are presented. Hydrogen spin density and tissue relaxation times T1, T2, and T2* are explained. The basic elements of a planar MR pulse sequence are described: section selection during tissue excitation, phase encoding, and frequency encoding during signal measurement.
ERIC Educational Resources Information Center
Powell, William R.; And Others
This report recommends that an annual report be made to the citizens of Florida about the state of literacy in Florida. The concept of literacy is defined in terms of levels of literacy and basic skills required to achieve the different levels. A review of the literature on literacy is the basis for three suggested levels of literacy: (1)…
A tutorial on information retrieval: basic terms and concepts
Zhou, Wei; Smalheiser, Neil R; Yu, Clement
2006-01-01
This informal tutorial is intended for investigators and students who would like to understand the workings of information retrieval systems, including the most frequently used search engines: PubMed and Google. Having a basic knowledge of the terms and concepts of information retrieval should improve the efficiency and productivity of searches. As well, this knowledge is needed in order to follow current research efforts in biomedical information retrieval and text mining that are developing new systems not only for finding documents on a given topic, but extracting and integrating knowledge across documents. PMID:16722601
Basic concepts and techniques of dental implants.
Tagliareni, Jonathan M; Clarkson, Earl
2015-04-01
Dental implants provide completely edentulous and partial edentulous patients the function and esthetics they had with natural dentition. It is critical to understand and apply predictable surgical principles when treatment planning and surgically restoring edentulous spaces with implants. This article defines basic implant concepts that should be meticulously followed for predictable results when treating patients and restoring dental implants. Topics include biological and functional considerations, biomechanical considerations, preoperative assessments, medical history and risk assessments, oral examinations, radiographic examinations, contraindications, and general treatment planning options. Copyright © 2015 Elsevier Inc. All rights reserved.
ERIC Educational Resources Information Center
Bureau of Naval Personnel, Washington, DC.
Basic concepts of nuclear structures, radiation, nuclear reactions, and health physics are presented in this text, prepared for naval officers. Applications to the area of nuclear power are described in connection with pressurized water reactors, experimental boiling water reactors, homogeneous reactor experiments, and experimental breeder…
Firewalking: A Lesson in Physics.
ERIC Educational Resources Information Center
Taylor, John R.
1989-01-01
Emphasizes firewalking as a good illustration of basic concepts in thermodynamics. Describes the basic principles of firewalking and other factors including the cooling of the surface embers, moisture of the feet, thick skin on the feet, tolerance for pain, and other uncontrolled factors. (YP)
Designing Networks that are Capable of Self-Healing and Adapting
2017-04-01
Undergrad. Res. Fellowship, visiting from Caltech. Undergraduate Eugene Park Math Duke Models of self-healing networks (undergrad. senior thesis...Graduate student Anastasia Deckard Math Duke 3rd/4th year PhD. Wrote software for simulation. Undergraduate Nick Day Math LIMS Summer project at...Harer gave a talk on this DTRA grant to undergraduate math majors at Duke. 11 Q UA D C HA R T Uploaded to the DTRA Basic and Fundamental Research
NASA Technical Reports Server (NTRS)
1983-01-01
The technical effort associated with the selection and definition of the recommended SRB-X concept is documented. Included are discussions concerning the trades leading to the selected concept, the analysis that established the concept's basic subsystem characteristics, selected configuration description and performance capabilities, launch site operations and facility needs, development schedule, cost characteristics, risk assessment, and a cursory comparison with other launch systems.
ERIC Educational Resources Information Center
Topal, Giray; Oral, Behcet; Ozden. Mustafa
2007-01-01
Aromaticity concept is given incorrect or incomplete to the student in secondary education and knowledge based on this basic concept has been caused to another misconception in future. How are the achievement levels relating to the comprehension of various characteristics of aromatic compounds for the first and third grade students attending…
Students' Alternative Conceptions about Electricity and Effect of Inquiry-Based Teaching Strategies
ERIC Educational Resources Information Center
Afra, Nada Chatila; Osta, Iman; Zoubeir, Wassim
2009-01-01
This study attempted to investigate the alternative conceptions that a group of 12 Lebanese students in a grade 9 class hold about electricity. It also attempted to evaluate learning outcomes of implementing in that class an inquiry-based module for the acquisition of conceptual understanding of basic concepts in electricity. Fourteen mostly…
Consumer Economics (Secondary): Teaching Strategies. Master Curriculum Guide in Economics.
ERIC Educational Resources Information Center
Clow, John E., Ed.
Designed to build up concepts presented in the Master Curriculum Guide volume "A Framework for Teaching the Basic Concepts," this collection of teacher guidelines and classroom lessons focuses on how economic concepts and an economic way of thinking can be incorporated into various units in consumer education courses or in courses at the secondary…
Time as a Basic Concept for Theory Building in Social Gerontology.
ERIC Educational Resources Information Center
Pastorello, Thomas
A typology of time-related concepts is put forth as a step toward the building of comprehensive theory in aging. The concepts derive from statistics (age, cohort, period effects), the theoretical writings of Sorokin (life course role sequences, durations and rates), the writings of Riley (on the synchronization of life course socialization and…
The Mediating Effect of Context Variation in Mixed Practice for Transfer of Basic Science
ERIC Educational Resources Information Center
Kulasegaram, Kulamakan; Min, Cynthia; Howey, Elizabeth; Neville, Alan; Woods, Nicole; Dore, Kelly; Norman, Geoffrey
2015-01-01
Applying a previously learned concept to a novel problem is an important but difficult process called transfer. Practicing multiple concepts together (mixed practice mode) has been shown superior to practicing concepts separately (blocked practice mode) for transfer. This study examined the effect of single and multiple practice contexts for both…
Generalizations Related to Concepts Important for Youth Orientation to the World of Work.
ERIC Educational Resources Information Center
Warren, Mary A.; And Others
A basic first step in building a curriculum contributing to the orientation of youth to world of work is identification of concepts important to that orientation. In this study, the generalizations within the concept framework were identified through a developmental process of analysis and synthesis, including a review of current literature, a…
Safety evaluation of high-speed rail bogie concepts.
DOT National Transportation Integrated Search
2013-10-01
The study defines the basic design concepts required to provide a safe, reliable, high-speed bogie for the next generation PRIIA passenger locomotive. The requirements and conditions for the U.S. market create unique design challenges that currently ...
An Industrially Developed Basic Chemistry Course.
ERIC Educational Resources Information Center
Collins, L. W.; Haws, L. D.
1979-01-01
Describes a practical, job-related, 3 1/2 month long, basic chemistry course developed by Monsanto Research Corporation to train laboratory technicians and service employees. The course, centered around 31 chemistry topics, is designed to supplement university courses and stresses application of concepts. (BT)
Sociolinguistics and the Counselling Process
ERIC Educational Resources Information Center
Conville, Richard L.; Ivey, Allen E.
1975-01-01
Sociolinguistics is the study of language as part of culture and society. Counselling, basically a linguistic-communicative process, has too often failed to consider systematic knowledge from related fields. This article discusses basic concepts of sociolinguistics and considers their relation to the counselling process. (Author)
Workplace Math I: Easing into Math.
ERIC Educational Resources Information Center
Wilson, Nancy; Goschen, Claire
This basic skills learning module includes instruction in performing basic computations, using general numerical concepts such as whole numbers, fractions, decimals, averages, ratios, proportions, percentages, and equivalents in practical situations. The problems are relevant to all aspects of the printing and manufacturing industry, with emphasis…
Remediation for Students With Mathematics Difficulties: An Intervention Study in Middle Schools.
Moser Opitz, Elisabeth; Freesemann, Okka; Prediger, Susanne; Grob, Urs; Matull, Ina; Hußmann, Stephan
As empirical studies have consistently shown, low achievement in mathematics at the secondary level can often be traced to deficits in the understanding of certain basic arithmetic concepts taught in primary school. The present intervention study in middle schools evaluated whether such learning deficits can be reduced effectively and whether the type of instruction influences students' progress. The sample consisted of 123 students in 34 classes, split among one control group and two intervention groups: (a) small group instruction and (b) independent work partially integrated into regular classrooms. Over a period of 14 weeks, students were taught basic concepts, such as place value and basic operations. In addition, they practiced fact retrieval and counting (in groups). Multilevel regression analyses demonstrated that the interventions can be used to reduce given deficits.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ketterer, S.P.
This manual is designed as a comprehensive hands-on instructional manual for learning the T{sub E}X* computer typesetting program in a classroom environment. Each section presents a new concept in careful detail, concluding with an exercise (T{sub E}Xercise) to reinforce the learning of the concept. The manual introduces the novice T{sub E}X user to the program's basic command structure, along with the concepts of grouping, producing accents, making font changes, and generating mathematical symbols. The T{sub E}Xercises guide the new user in generating text containing footnotes, multilevel lists, and hanging indentations, as well as in magnifying text for viewgraphs. Once themore » basic text generation is defined, the more advanced topics of formatting math equations and tables are explained. A full range of math capabilities is presented --- beginning with simple one-line equations, progressing through complex numbered and aligned equations, and concluding with matrices. The sections on table generation present the basic concepts in T{sub E}X's table-formatting program and then build on them. The new user first learns to construct simple tables, and with careful explanations and guidance, learns to add one new table enhancement at a time. By the conclusion of these sections, the user can construct tables with horizontal and vertical rules and with column entries that are paragraphs. 1 ref.« less
NASA Technical Reports Server (NTRS)
Farassat, Fereidoun; Myers, Michael K.
2011-01-01
This paper is the first part of a three part tutorial on multidimensional generalized functions (GFs) and their applications in aeroacoustics and fluid mechanics. The subject is highly fascinating and essential in many areas of science and, in particular, wave propagation problems. In this tutorial, we strive to present rigorously and clearly the basic concepts and the tools that are needed to use GFs in applications effectively and with ease. We give many examples to help the readers in understanding the mathematical ideas presented here. The first part of the tutorial is on the basic concepts of GFs. Here we define GFs, their properties and some common operations on them. We define the important concept of generalized differentiation and then give some interesting elementary and advanced examples on Green's functions and wave propagation problems. Here, the analytic power of GFs in applications is demonstrated with ease and elegance. Part 2 of this tutorial is on the diverse applications of generalized derivatives (GDs). Part 3 is on generalized Fourier transformations and some more advanced topics. One goal of writing this tutorial is to convince readers that, because of their powerful operational properties, GFs are absolutely essential and useful in engineering and physics, particularly in aeroacoustics and fluid mechanics.
Basic principles, methodology, and applications of remote sensing in agriculture
NASA Technical Reports Server (NTRS)
Moreira, M. A. (Principal Investigator); Deassuncao, G. V.
1984-01-01
The basic principles of remote sensing applied to agriculture and the methods used in data analysis are described. Emphasis is placed on the importance of developing a methodology that may help crop forecast, basic concepts of spectral signatures of vegetation, the methodology of the LANDSAT data utilization in agriculture, and the remote sensing program application of INPE (Institute for Space Research) in agriculture.
Machine to harvest slash, brush, and thinnings for fuel and fiber- a concept
P. Koch; D.W. McKenzie
1976-01-01
It is proposed that biomass from noncommercial thinnings, and from logging slash residual after harvest, be hogged and recovered for fuel and fiber. Such a procedure might yield two dividends of biomass totalling as much as 90,000 kg per ha (40 tons per acre, green weight basis) from each rotation of southern pine. For sites deficient in organic matter, it is...
FORWARD: DESERTIFICATION IN THE MEDITERRANEAN REGION: A SECURITY ISSUE
The Workshop focused on two basic concepts: security and desertification and their linkages. Since the end of the Cold War, traditional security concepts based on national sovereignty and territorial security have increasingly been brought under review. Currently, a broader defin...
Application of thermochemical modeling to aircraft interior polymeric materials
DOT National Transportation Integrated Search
1982-06-01
This report summarizes the results from a twelve-month study of the feasibility of applying certain basic concepts in the thermochemical modeling to aircraft cabin fire safety. The concepts developed earlier on a NASA-sponsored program were applied t...
ERIC Educational Resources Information Center
Gomez, Enrique Jimenez; Duran, Eugenio Fernandez
1998-01-01
Analyzes didactic problems related to the inseparability of electric charge from the mass, the impossibility of its direct observation, and the meaning associated with the basic concepts of electricity. Contains 44 references. (DDR)
PACS—Realization of an adaptive concept using pressure actuated cellular structures
NASA Astrophysics Data System (ADS)
Gramüller, B.; Boblenz, J.; Hühne, C.
2014-10-01
A biologically inspired concept is investigated which can be utilized to develop energy efficient, lightweight and applicational flexible adaptive structures. Building a real life morphing unit is an ambitious task as the numerous works in the particular field show. Summarizing fundamental demands and barriers regarding shape changing structures, the basic challenges of designing morphing structures are listed. The concept of Pressure Actuated Cellular Structures (PACS) is arranged within the recent morphing activities and it is shown that it complies with the underlying demands. Systematically divided into energy-related and structural subcomponents the working principle is illuminated and relationships between basic design parameters are expressed. The analytical background describing the physical mechanisms of PACS is presented in concentrated manner. This work focuses on the procedure of dimensioning, realizing and experimental testing of a single cell and a single row cantilever made of PACS. The experimental outcomes as well as the results from the FEM computations are used for evaluating the analytical methods. The functionality of the basic principle is thus validated and open issues are determined pointing the way ahead.
Current Practices in Teaching Introductory Epidemiology: How We Got Here, Where to Go
Keyes, Katherine M.; Galea, Sandro
2014-01-01
The number of students and disciplines requiring basic instruction in epidemiologic methods is growing. As a field, we now have a lexicon of epidemiologic terminology and particular methods that have developed and become canonical through the historical development of the field. Yet, many of our basic concepts remain elusive to some students, particularly those not pursuing a career in epidemiology. Further, disagreement and redundancy across basic terms limit their utility in teaching epidemiology. Many approaches to teaching epidemiology generally start with labeling key concepts and then move on to explain them. We submit that an approach grounded not in labels but in foundational concepts may offer a useful adjunct to introductory epidemiology education. We propose 7 foundational steps in conducting an epidemiologic study and provide examples of how these steps can be operationalized, using simple graphics that articulate how populations are defined, samples are selected, and individuals are followed to count cases. A reorganization of introductory epidemiology around core first principles may be an effective way forward for educating the next generation of public health scientists. PMID:25190677
Basic concepts for the design of high-efficiency single-junction and multibandgap solar cells
NASA Technical Reports Server (NTRS)
Fan, J. C. C.
1985-01-01
Concepts for obtaining practical solar-cell modules with one-sun efficiencies up to 30 percent at air mass 1 are now well understood. Such high-efficiency modules utilize multibandgap structures. To achieve module efficiencies significantly above 30 percent, it is necessary to employ different concepts such as spectral compression and broad-band detection. A detailed description of concepts for the design of high-efficiency multibandgap solar cells is given.
Thermodynamic and Kinetic Properties of the Electrochemical Cell.
ERIC Educational Resources Information Center
Smith, Donald E.
1983-01-01
Describes basic characteristics of the electrochemical cell. Also describes basic principles of electrochemical procedures and use of these concepts to explain use of the term "primarily" in discussions of methods primarily responsive to equilibrium cell potential, bulk ohmic resistance, and the Faradaic impedance. (JN)
ERIC Educational Resources Information Center
Haga, Enoch J.
1971-01-01
The Certificate in Data Education (Basic) examination is designed to certify that successful candidates are academically proficient in those principles and concepts of automation, computing, and data processing (including social and user implications) which are usually taught in basic introductory courses at the college or university level. (CK)
ERIC Educational Resources Information Center
Busch, Phyllis S.
1985-01-01
Provides directions for basic science experiments which demonstrate the rain cycle, fundamentals of cloud formation, and testing for the presence of acidity in local rainwater. Describes materials required, step-by-step instructions, and discussion topics. (NEC)
Radiological Dispersion Devices and Basic Radiation Science
NASA Astrophysics Data System (ADS)
Bevelacqua, Joseph John
2010-05-01
Introductory physics courses present the basic concepts of radioactivity and an overview of nuclear physics that emphasizes the basic decay relationship and the various types of emitted radiation. Although this presentation provides insight into radiological science, it often fails to interest students to explore these concepts in a more rigorous manner. One reason for limited student interest is the failure to link the discussion to topics of current interest. The author has found that presenting this material with a link to radiological dispersion devices (RDDs), or dirty bombs, and their associated health effects provides added motivation for students. The events of Sept. 11, 2001, and periodic media focus on RDDs heighten student interest from both a scientific curiosity as well as a personal protection perspective. This article presents a framework for a more interesting discussion of the basics of radiation science and their associated health effects. The presentation can be integrated with existing radioactivity lectures or added as a supplementary or enrichment activity.
Certain Basic Concepts of Teaching Turkish as a Foreign Language
ERIC Educational Resources Information Center
Sen, Ülker
2016-01-01
Concept that is defined to be the intangible and general designs emerging in a mind that belongs to an object or thought, has become both subject and object of a very large field ranging from philosophy to linguistics, from social sciences to science. Regardless of which field is in question, the unity of concept is important in order to pave the…
Daniel R. Williams
2008-01-01
Place ideas are capturing increasing attention in recreation and natural resource management. But there are important and sometimes incompatible differences among the various concepts. In this paper I describe some of the reasons for the growing interest in place concepts and distinguish between four basic approaches: attitude, meaning, ethical, and political. My aim...
ERIC Educational Resources Information Center
Aryawibawa, I Nyoman
2010-01-01
Many scholars have proposed concepts relevant to spatial reference. Herskovits (1982) proposed that the topological concepts support, contiguity and containment are basic in English, while Levinson et al.'s (2003) examination of nine unrelated languages revealed that the concept attachment is primary. Neither of these proposals is confirmed in…
Janice VanCleave's the Human Body for Every Kid: Easy Activities That Make Learning Science Fun.
ERIC Educational Resources Information Center
VanCleave, Janice
This book provides fun experiments that teach known concepts about the human body. It is designed to teach facts, concepts, and problem-solving strategies. The scientific concepts presented can be applied to many similar situations, and the exercises and activities were selected for their ability to be explained in basic terms with little…
ERIC Educational Resources Information Center
Heilprin, Laurence B.
The literature of knowledge is a very large system in the cybernetic sense of intractibility to control. Improving access to it needs some simplifying theory. A step in this direction is a hypothesis constructed from basic concepts. These include cybernetic concepts of variety and requisite variety; a version of the mathematical concept of…
The Concepts of PPBS and Approaches to Their Application.
ERIC Educational Resources Information Center
Fielden, John
The basic concepts of the classic PPBS are summarized, and then attention is directed toward the process by which this has been modified by its collision with the values of the university. The form taken by the new modified PPBS is examined and its component concepts and techniques are identified. It is concluded that the new PPBS has limitations…
USDA-ARS?s Scientific Manuscript database
A recombinant live attenuated influenza virus (LAIV) deltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and the six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was attenuated in chickens, mice and fe...
Visualization: a tool for enhancing students' concept images of basic object-oriented concepts
NASA Astrophysics Data System (ADS)
Cetin, Ibrahim
2013-03-01
The purpose of this study was twofold: to investigate students' concept images about class, object, and their relationship and to help them enhance their learning of these notions with a visualization tool. Fifty-six second-year university students participated in the study. To investigate his/her concept images, the researcher developed a survey including open-ended questions, which was administered to the participants. Follow-up interviews with 12 randomly selected students were conducted to explore their answers to the survey in depth. The results of the first part of the research were utilized to construct visualization scenarios. The students used these scenarios to develop animations using Flash software. The study found that most of the students experienced difficulties in learning object-oriented notions. Overdependence on code-writing practice and examples and incorrectly learned analogies were determined to be the sources of their difficulties. Moreover, visualization was found to be a promising approach in facilitating students' concept images of basic object-oriented notions. The results of this study have implications for researchers and practitioners when designing programming instruction.
Contemporary concepts of dissociation.
Avdibegović, Esmina
2012-10-01
The concept of dissociation was developed in the late 19th century by Pierre Janet for conditions of "double consciousness" in hypnosis, hysteria, spirit possession and mediumship. He defined dissociation as a deficit in the capacity of integration of two or more different "systems of ideas and functions that constitute personality", and suggested that it can be related to a genetic component, to severe illness and fatigue, and particularly to experiencing adverse, potentially traumatizing events. By the late 20th century, various and often contradictory concepts of dissociation were suggested, which were either insufficient or exceedingly including when compared to the original idea. Currently, dissociation is used to describe a wide range of normal and abnormal phenomena as a process in which behaviour, thoughts and emotions can become separated one from another. A complete presentation of mechanisms involved in dissociation is still unknown. Scientific research on basic processes of dissociation is derived mainly from studies of hypnosis and post-traumatic stress disorder. Given the controversies in modern concepts of dissociation, some researchers and theorists suggest return to the original understanding of dissociation as a basic premise for the further development of the concept of dissociation.
Romero-Martínez, Ángel; Lila, Marisol; Catalá-Miñana, Alba; Williams, Ryan K.; Moya-Albiol, Luis
2013-01-01
Alcohol consumption, a larger history of childhood parental rejection, and high prenatal androgen exposure have been linked with facilitation and high risk of recidivism in intimate partner violence (IPV) perpetrators. Participants were distributed into two groups according to their alcohol consumption scores as high (HA) and low (LA). HA presented a higher history of childhood parental rejection, prenatal masculinization (smaller 2D:4D ratio), and violence-related scores than LA IPV perpetrators. Nonetheless, the former showed poor socio-cognitive skills performance (cognitive flexibility, emotional recognition and cognitive empathy). Particularly in HA IPV perpetrators, the history of childhood parental rejection was associated with high hostile sexism and low cognitive empathy. Moreover, a masculinized 2D:4D ratio was associated with high anger expression and low cognitive empathy. Parental rejection during childhood and early androgen exposure are relevant factors for the development of violence and the lack of adequate empathy in adulthood. Furthermore, alcohol abuse plays a key role in the development of socio-cognitive impairments and in the proneness to violence and its recidivism. These findings contribute to new coadjutant violence intervention programs, focused on the rehabilitation of basic executive functions and emotional decoding processes and on the treatment of alcohol dependence. PMID:23965927
NASA Astrophysics Data System (ADS)
Sukmono, Abdi; Ardiansyah
2017-01-01
Paddy is one of the most important agricultural crop in Indonesia. Indonesia’s consumption of rice per capita in 2013 amounted to 78,82 kg/capita/year. In 2017, the Indonesian government has the mission of realizing Indonesia became self-sufficient in food. Therefore, the Indonesian government should be able to seek the stability of the fulfillment of basic needs for food, such as rice field mapping. The accurate mapping for rice field can use a quick and easy method such as Remote Sensing. In this study, multi-temporal Landsat 8 are used for identification of rice field based on Rice Planting Time. It was combined with other method for extract information from the imagery. The methods which was used Normalized Difference Vegetation Index (NDVI), Principal Component Analysis (PCA) and band combination. Image classification is processed by using nine classes, those are water, settlements, mangrove, gardens, fields, rice fields 1st, rice fields 2nd, rice fields 3rd and rice fields 4th. The results showed the rice fields area obtained from the PCA method was 50,009 ha, combination bands was 51,016 ha and NDVI method was 45,893 ha. The accuracy level was obtained PCA method (84.848%), band combination (81.818%), and NDVI method (75.758%).
Romero-Martínez, Ángel; Lila, Marisol; Catalá-Miñana, Alba; Williams, Ryan K; Moya-Albiol, Luis
2013-08-20
Alcohol consumption, a larger history of childhood parental rejection, and high prenatal androgen exposure have been linked with facilitation and high risk of recidivism in intimate partner violence (IPV) perpetrators. Participants were distributed into two groups according to their alcohol consumption scores as high (HA) and low (LA). HA presented a higher history of childhood parental rejection, prenatal masculinization (smaller 2D:4D ratio), and violence-related scores than LA IPV perpetrators. Nonetheless, the former showed poor socio-cognitive skills performance (cognitive flexibility, emotional recognition and cognitive empathy). Particularly in HA IPV perpetrators, the history of childhood parental rejection was associated with high hostile sexism and low cognitive empathy. Moreover, a masculinized 2D:4D ratio was associated with high anger expression and low cognitive empathy. Parental rejection during childhood and early androgen exposure are relevant factors for the development of violence and the lack of adequate empathy in adulthood. Furthermore, alcohol abuse plays a key role in the development of socio-cognitive impairments and in the proneness to violence and its recidivism. These findings contribute to new coadjutant violence intervention programs, focused on the rehabilitation of basic executive functions and emotional decoding processes and on the treatment of alcohol dependence.
Sadygov, Rovshan G; Cociorva, Daniel; Yates, John R
2004-12-01
Database searching is an essential element of large-scale proteomics. Because these methods are widely used, it is important to understand the rationale of the algorithms. Most algorithms are based on concepts first developed in SEQUEST and PeptideSearch. Four basic approaches are used to determine a match between a spectrum and sequence: descriptive, interpretative, stochastic and probability-based matching. We review the basic concepts used by most search algorithms, the computational modeling of peptide identification and current challenges and limitations of this approach for protein identification.
Minimize system cost by choosing optimal subsystem reliability and redundancy
NASA Technical Reports Server (NTRS)
Suich, Ronald C.; Patterson, Richard L.
1993-01-01
The basic question which we address in this paper is how to choose among competing subsystems. This paper utilizes both reliabilities and costs to find the subsystems with the lowest overall expected cost. The paper begins by reviewing some of the concepts of expected value. We then address the problem of choosing among several competing subsystems. These concepts are then applied to k-out-of-n: G subsystems. We illustrate the use of the authors' basic program in viewing a range of possible solutions for several different examples. We then discuss the implications of various solutions in these examples.
Introduction to molecular topology: basic concepts and application to drug design.
Gálvez, Jorge; Gálvez-Llompart, María; García-Domenech, Ramón
2012-09-01
In this review it is dealt the use of molecular topology (MT) in the selection and design of new drugs. After an introduction of the actual methods used for drug design, the basic concepts of MT are defined, including examples of calculation of topological indices, which are numerical descriptors of molecular structures. The goal is making this calculation familiar to the potential students and allowing a straightforward comprehension of the topic. Finally, the achievements obtained in this field are detailed, so that the reader can figure out the great interest of this approach.
ERIC Educational Resources Information Center
Taylor, Kelly R.
2001-01-01
A brief list of basic legal concepts and terms to help principals become more familiar with some of the Constitutional and statutory procedural and substantive aspects of school law, including, for example, concepts like due process and privacy and terms like En Banc and De Facto. (PKP)
ERIC Educational Resources Information Center
Smith, Penny
1985-01-01
Reviews: "ArithMagic (Counting, Addition, Subtraction)" which uses graphics to illustrate/review basic arithmetic concepts; "The Sweet Shop" which uses graphics (and a character called Mr. Jellybean) to teach arithmetic concepts; and "Math Magic," a monster-filled arcade game that teaches addition and subtraction.…
ERIC Educational Resources Information Center
Garruto, Patricia J.
2012-01-01
High school graduates continue to enter post-secondary education lacking in basic mathematical skills and thus not academically prepared to enroll in college-level mathematics courses (ACT, 2010). Although it can be argued that those mathematical concepts should have been mastered in grades K-12, educating those students in basic skills…
ERIC Educational Resources Information Center
Enriquez, Galo, Ed.
This booklet defines and considers basic education and reports on the concept as it is implemented and developed in Argentina, Colombia, Chile, Spain, and Peru. Basic education, as defined here, generally refers to the education of children between the ages of 7 and 16 years. Initial remarks define the issue and discuss general principles. The…
Basic symptoms and the prediction of first-episode psychosis.
Schultze-Lutter, Frauke; Ruhrmann, Stephan; Fusar-Poli, Paolo; Bechdolf, Andreas; Schimmelmann, Benno G; Klosterkötter, Joachim
2012-01-01
Recent focus on early detection and intervention in psychosis has renewed interest in subtle psychopathology beyond positive and negative symptoms. Such self-experienced sub-clinical disturbances are described in detail by the basic symptom concept. This review will give an introduction into the concept of basic symptoms and describe the development of the current instruments for their assessment, the Schizophrenia Proneness Instrument, Adult (SPI-A) and Child and Youth version (SPI-CY), as well as of the two at-risk criteria: the at-risk criterion Cognitive-Perceptive Basic Symptoms (COPER) and the high-risk criterion Cognitive Disturbances (COGDIS). Further, an overview of prospective studies using both or either basic symptom criteria and transition rates related to these will be given, and the potential benefit of combining ultra-high risk criteria, particularly attenuated psychotic symptoms, and basic symptom criteria will be discussed. Finally, their prevalence in psychosis patients, i.e. the sensitivity, as well as in general population samples will be described. It is concluded that both COPER and COGDIS are able to identify subjects at a high risk of developing psychosis. Further, they appear to be sufficiently frequent prior to onset of the first psychotic episode as well as sufficiently rare in persons of general population to be considered as valuable for an early detection of psychosis.
TRAINING IN INDUSTRY--THE MANAGEMENT OF LEARNING.
ERIC Educational Resources Information Center
BASS, BERNARD M.; VAUGHAN, JAMES A.
THE PRINCIPLES OF LEARNING BEHAVIOR DERIVED THROUGH LABORATORY STUDY CAN BE EXTENDED TO EXPLAIN MUCH OF THE COMPLEX LEARNING REQUIRED IN INDUSTRIAL TRAINING PROGRAMS. A REVIEW OF THE BASIC PRINCIPLES OF HUMAN LEARNING INTRODUCES FOUR BASIC CONCEPTS--DRIVE, STIMULUS, RESPONSE, AND REINFORCER--AND DISCUSSES CLASSICAL AND INSTRUMENTAL CONDITIONING…
ERIC Educational Resources Information Center
Ray, Nancy L.
This paper presents basic principles and theories of motivation, attempts to provide a better understanding of the concept, and explores the role motivation plays in learning. Basic theories of motivation are reviewed including: Freud's belief in motivation by the id, unconscious forces, and sexual stages; Jung and Adler's belief that people are…
Environmental Awareness: Just a Pane of Glass Away.
ERIC Educational Resources Information Center
Kopchynski, Kevin
1982-01-01
Highlights several basic ecological principles and suggests corresponding classroom activities for grades five to eight that revolve around a freshwater aquarium. Basic ecological concepts, adaptations, characteristics of aquatic habitats, and pollution problems are outlined in separate tables. A short list of resource materials is included.…
Teaching the Rules of Debit and Credit
ERIC Educational Resources Information Center
Potts, Andrew J.
1974-01-01
A fundamental method of explaining the basic accounting principles and concepts (debit, credit, basic accounting equation) which includes visual aids, reference to local businesses, and drill, does much toward increasing the student's skill and enhancing his understanding of the subject matter. (Sample transparencies are included.) (Author/AJ)
Digital Simulation and Modelling.
ERIC Educational Resources Information Center
Hawthorne, G. B., Jr.
A basically tutorial point of view is taken in this general discussion. The author examines the basic concepts and principles of simulation and modelling and the application of digital computers to these tasks. Examples of existing simulations, a discussion of the applicability and feasibility of simulation studies, a review of simulation…
Incorporating Basic Optical Microscopy in the Instrumental Analysis Laboratory
ERIC Educational Resources Information Center
Flowers, Paul A.
2011-01-01
A simple and versatile approach to incorporating basic optical microscopy in the undergraduate instrumental analysis laboratory is described. Attaching a miniature CCD spectrometer to the video port of a standard compound microscope yields a visible microspectrophotometer suitable for student investigations of fundamental spectrometry concepts,…
Heavy Equipment Mechanic. Instructor Edition.
ERIC Educational Resources Information Center
Hendrix, Laborn J.; And Others
This manual is intended to assist heavy equipment instructors in teaching the latest concepts and functions of heavy equipment. It includes 7 sections and 27 instructional units. Sections (and units) are: orientation (shop safety and first aid, hand tools and miscellaneous tools, measuring, basic rigging and hoisting), engines (basic engine…
Basic Stuff--Ideas for Implementation.
ERIC Educational Resources Information Center
Fox, Connie
Use of the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD) "Basic Stuff" (1981) series (which includes six texts explaining each concept and three texts illustrating their use in the elementary, middle, and secondary schools) is recommended for physical education teacher preparation programs. A study was undertaken…
The Administration of Outdoor Education Programs.
ERIC Educational Resources Information Center
Lewis, Charles A., Jr.
Designed for those interested in the mechanics of establishing outdoor education programs, this text is basically a guide to program development and includes examples of procedures, forms, conceptualizations, etc. Chapters deal with: (1) the contemporary education scene (an overview); (2) the basic concepts of outdoor education (17 concept…
College Financial Management: Basics for Administrators.
ERIC Educational Resources Information Center
Carter, E. Eugene
Basic economic concepts applicable for college financial management are considered, along with the characteristics of financial instruments available to universities that have money to invest for short-term or long-term purposes. A discussion of various financial securities provides information for the endowment manager who has to select among…
An Introduction to Research and the Computer: A Self-Instructional Package.
ERIC Educational Resources Information Center
Vasu, Ellen Storey; Palmer, Richard I.
This self-instructional package includes learning objectives, definitions, exercises, and feedback for learning some basic concepts and skills involved in using computers for analyzing data and understanding basic research terminology. Learning activities are divided into four sections: research and research hypotheses; variables, cases, and…
Fischer, M.; Kelley, A. M.; Ward, E. J.; ...
2017-02-03
Most research on bioenergy short rotation woody crops (SRWC) has been dedicated to the genera Populus and Salix. These species generally require relatively high-input culture, including intensive weed competition control, which increases costs and environmental externalities. Widespread native early successional species, characterized by high productivity and good coppicing ability, may be better adapted to local environmental stresses and therefore could offer alternative low-input bioenergy production systems. In order to test this concept, we established a three-year experiment comparing a widely-used hybrid poplar (Populus nigra × P. maximowiczii, clone ‘NM6’) to two native species, American sycamore (Platanus occidentalis L.) and tuliptreemore » (Liriodendron tulipifera L.) grown under contrasting weed and pest control at a coastal plain site in eastern North Carolina, USA. Mean cumulative aboveground wood production was significantly greater in sycamore, with yields of 46.6 Mg ha -11 under high-inputs and 32.7 Mg ha -1 under low-input culture, which rivaled the high-input NM6 yield of 32.9 Mg ha -1. NM6 under low-input management provided noncompetitive yield of 6.2 Mg ha -1. We also found that sycamore showed superiority in survival, biomass increment, weed resistance, treatment convergence, and within-stand uniformity. All are important characteristics for a bioenergy feedstock crop species, leading to reliable establishment and efficient biomass production. Poor performance in all traits was found for tuliptree, with a maximum yield of 1.2 Mg ha -1, suggesting this native species is a poor choice for SRWC. We then conclude that careful species selection beyond the conventionally used genera may enhance reliability and decrease negative environmental impacts of the bioenergy biomass production sector.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Schwarz, S.; Ellen, R.P.; Grove, D.A.
1987-10-01
There is limited evidence, mostly indirect, to suggest that the adherence of Bacteroides gingivalis to teeth may be enhanced by the presence of gram-positive dental plaque bacteria like Actinomyces viscosus. The purpose of this study was to carry out direct quantitative assessments of the cohesion of B gingivalis and A. viscosus by using an in vitro assay modeled on the natural sequence in which these two species colonize the teeth. The assay allowed comparisons to be made of the adherence of /sup 3/H-labeled B. gingivalis 2561 and 381 to saliva-coated hydroxyapatite beads (S-HA) and A. viscosus WVU627- or T14V-coated S-HAmore » (actinobeads) in equilibrium and kinetics binding studies. A series of preliminary binding studies with 3H-labeled A. viscosus and parallel studies by scanning electron microscopy with unlabeled A. viscosus were conducted to establish a protocol by which actinobeads suitable for subsequent Bacteroides adherence experiments could be prepared. By scanning electron microscopy, the actinobeads had only small gaps of exposed S-HA between essentially irreversibly bound A. viscosus cells. Furthermore, B. gingivalis cells appeared to bind preferentially to the Actinomyces cells instead of the exposed S-HA. B. gingivalis binding to both S-HA and actinobeads was saturable with at least 2 X 10(9) to 3 X 10(9) cells per ml, and equilibrium with saturating concentrations was reached within 10 to 20 min. B. gingivalis always bound in greater numbers to the actinobeads than to S-HA. These findings provide direct measurements supporting the concept that cohesion with dental plaque bacteria like A. viscosus may foster the establishment of B. gingivalis on teeth by enhancing its adherence.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fischer, M.; Kelley, A. M.; Ward, E. J.
Most research on bioenergy short rotation woody crops (SRWC) has been dedicated to the genera Populus and Salix. These species generally require relatively high-input culture, including intensive weed competition control, which increases costs and environmental externalities. Widespread native early successional species, characterized by high productivity and good coppicing ability, may be better adapted to local environmental stresses and therefore could offer alternative low-input bioenergy production systems. In order to test this concept, we established a three-year experiment comparing a widely-used hybrid poplar (Populus nigra × P. maximowiczii, clone ‘NM6’) to two native species, American sycamore (Platanus occidentalis L.) and tuliptreemore » (Liriodendron tulipifera L.) grown under contrasting weed and pest control at a coastal plain site in eastern North Carolina, USA. Mean cumulative aboveground wood production was significantly greater in sycamore, with yields of 46.6 Mg ha -11 under high-inputs and 32.7 Mg ha -1 under low-input culture, which rivaled the high-input NM6 yield of 32.9 Mg ha -1. NM6 under low-input management provided noncompetitive yield of 6.2 Mg ha -1. We also found that sycamore showed superiority in survival, biomass increment, weed resistance, treatment convergence, and within-stand uniformity. All are important characteristics for a bioenergy feedstock crop species, leading to reliable establishment and efficient biomass production. Poor performance in all traits was found for tuliptree, with a maximum yield of 1.2 Mg ha -1, suggesting this native species is a poor choice for SRWC. We then conclude that careful species selection beyond the conventionally used genera may enhance reliability and decrease negative environmental impacts of the bioenergy biomass production sector.« less
Lötter, Mervyn C; Beck, Hans T
2004-01-01
Background Mixed evergreen forests form the smallest, most widely distributed and fragmented biome in southern Africa. Within South Africa, 44% of this vegetation type has been transformed. Afromontane forest only covers 0.56 % of South Africa, yet it contains 5.35% of South Africa's plant species. Prior to this investigation of the indigenous forests on the Blyde River Canyon Nature Reserve (BRCNR), very little was known about the size, floristic composition and conservation status of the forest biome conserved within the reserve. We report here an inventory of the forest size, fragmentation, species composition and the basic floristic communities along environmental gradients. Results A total of 2111 ha of forest occurs on Blyde River Canyon Nature Reserve. The forest is fragmented, with a total of 60 forest patches recorded, varying from 0.21 ha to 567 ha in size. On average, patch size was 23 ha. Two forest communities – high altitude moist afromontane forest and low altitude dry afromontane forest – are identified. Sub-communities are recognized based on canopy development and slope, respectively. An altitudinal gradient accounts for most of the variation within the forest communities. Conclusion BRCNR has a fragmented network of small forest patches that together make up 7.3% of the reserve's surface area. These forest patches host a variety of forest-dependent trees, including some species considered rare, insufficiently known, or listed under the Red Data List of South African Plants. The fragmented nature of the relatively small forest patches accentuates the need for careful fire management and stringent alien plant control. PMID:15287991
Aminopropyl-Silica Hybrid Particles as Supports for Humic Acids Immobilization
Sándor, Mónika; Nistor, Cristina Lavinia; Szalontai, Gábor; Stoica, Rusandica; Nicolae, Cristian Andi; Alexandrescu, Elvira; Fazakas, József; Oancea, Florin; Donescu, Dan
2016-01-01
A series of aminopropyl-functionalized silica nanoparticles were prepared through a basic two step sol-gel process in water. Prior to being aminopropyl-functionalized, silica particles with an average diameter of 549 nm were prepared from tetraethyl orthosilicate (TEOS), using a Stöber method. In a second step, aminopropyl-silica particles were prepared by silanization with 3-aminopropyltriethoxysilane (APTES), added drop by drop to the sol-gel mixture. The synthesized amino-functionalized silica particles are intended to be used as supports for immobilization of humic acids (HA), through electrostatic bonds. Furthermore, by inserting beside APTES, unhydrolysable mono-, di- or trifunctional alkylsilanes (methyltriethoxy silane (MeTES), trimethylethoxysilane (Me3ES), diethoxydimethylsilane (Me2DES) and 1,2-bis(triethoxysilyl)ethane (BETES)) onto silica particles surface, the spacing of the free amino groups was intended in order to facilitate their interaction with HA large molecules. Two sorts of HA were used for evaluating the immobilization capacity of the novel aminosilane supports. The results proved the efficient functionalization of silica nanoparticles with amino groups and showed that the immobilization of the two tested types of humic acid substances was well achieved for all the TEOS/APTES = 20/1 (molar ratio) silica hybrids having or not having the amino functions spaced by alkyl groups. It was shown that the density of aminopropyl functions is low enough at this low APTES fraction and do not require a further spacing by alkyl groups. Moreover, all the hybrids having negative zeta potential values exhibited low interaction with HA molecules. PMID:28787834
NASA Astrophysics Data System (ADS)
Rita Otero, Marıa; Arlego, Marcelo; Prodanoff, Fabiana
2016-05-01
In this work, we investigate the conceptualization of the basic aspects of Special Relativity (SR) at secondary school level. We have conducted our research along the lines of the Theory of Conceptual Fields (TCF) proposed by Vergnaud (Vergnaud G., Infancia y Aprendizaje, 36 (2013) 131). The investigation consisted in the design, implementation and evaluation of a didactic sequence specially elaborated to conceptualize the basic aspects of SR. The proposal is composed by eight situations, complemented with a set of exercises. It was carried out in two classrooms with students of the last year of secondary level (17years old, N = 43 . The conceptualization was analyzed in a classroom context, where the selected situations are essential to promote the emergence of the relevant concepts.
Effect of mitomycin on normal dermal fibroblast and HaCat cell: an in vitro study
Wang, Yao-wen; Ren, Ji-hao; Xia, Kun; Wang, Shu-hui; Yin, Tuan-fang; Xie, Ding-hua; Li, Li-hua
2012-01-01
Objective: To evaluate the effects of mitomycin on the growth of human dermal fibroblast and immortalized human keratinocyte line (HaCat cell), particularly the effect of mitomycin on intracellular messenger RNA (mRNA) synthesis of collagen and growth factors of fibroblast. Methods: The normal dermal fibroblast and HaCat cell were cultured in vitro. Cell cultures were exposed to 0.4 and 0.04 mg/ml of mitomycin solution, and serum-free culture medium was used as control. The cellular morphology change, growth characteristics, cell proliferation, and apoptosis were observed at different intervals. For the fibroblasts, the mRNA expression changes of transforming growth factor (TGF)-β1, basic fibroblast growth factor (bFGF), procollagen I, and III were detected by reverse transcription polymerase chain reaction (RT-PCR). Results: The cultured normal human skin fibroblast and HaCat cell grew exponentially. A 5-min exposure to mitomycin at either 0.4 or 0.04 mg/ml caused marked dose-dependent cell proliferation inhibition on both fibroblasts and HaCat cells. Cell morphology changed, cell density decreased, and the growth curves were without an exponential phase. The fibroblast proliferated on the 5th day after the 5-min exposure of mitomycin at 0.04 mg/ml. Meanwhile, 5-min application of mitomycin at either 0.04 or 0.4 mg/ml induced fibroblast apoptosis but not necrosis. The apoptosis rate of the fibroblast increased with a higher concentration of mytomycin (p<0.05). A 5-min exposure to mitomycin at 0.4 mg/ml resulted in a marked decrease in the mRNA production of TGF-β1, procollagen I and III, and a marked increase in the mRNA production of bFGF. Conclusions: Mitomycin can inhibit fibroblast proliferation, induce fibroblast apoptosis, and regulate intracellular protein expression on mRNA levels. In additon, mitomycin can inhibit HaCat cell proliferation, so epithelial cell needs more protecting to avoid mitomycin’s side effect when it is applied clinically. PMID:23225855
Inculcating Quality Concepts in the US Air Force: Right Music, Wrong Step
1994-04-01
CONCEPTS IN THE US AIR FORCE: RIGHT MUSIC , WRONG STEP Acceslon For NTIS CRA&J DTIC TAB Unannounced fJ by Justification Barbara A. Kucharczyk By. Lieutenant...TITLE: Inculcating Quality Concepts in the US Air Force: Right Music , Wrong Step AUTHOR: Barbara A. Kucharczyk, Lieutenant Colonel, USAF In its...perceived attitudinal backlash.4 While basic quality concepts are certainly the right music , many Air Force members are dancing the wrong step. Why? This
Using Concept Space to Verify Hyponymy in Building a Hyponymy Lexicon
NASA Astrophysics Data System (ADS)
Liu, Lei; Zhang, Sen; Diao, Lu Hong; Yan, Shu Ying; Cao, Cun Gen
Verification of hyponymy relations is a basic problem in knowledge acquisition. We present a method of hyponymy verification based on concept space. Firstly, we give the definition of concept space about a group of candidate hyponymy relations. Secondly we analyze the concept space and define a set of hyponymy features based on the space structure. Then we use them to verify candidate hyponymy relations. Experimental results show that the method can provide adequate verification of hyponymy.
ERIC Educational Resources Information Center
Pooley, Robert C.; Golub, Lester S.
Emphasizing the behavioral and social aspects of language as a foundation for instruction, 16 concepts for learning the structure of English in grades 7-9 are outlined in an attempt to set down in logical order the basic concepts involved in the understanding of the English language. The concepts begin with a recognition of the social purposes of…
On the concept of individual in ecology and evolution.
Metz, J A J
2013-03-01
Part of the art of theory building is to construct effective basic concepts, with a large reach and yet powerful as tools for getting at conclusions. The most basic concept of population biology is that of individual. An appropriately reengineered form of this concept has become the basis for the theories of structured populations and adaptive dynamics. By appropriately delimiting individuals, followed by defining their states as well as their environment, it become possible to construct the general population equations that were introduced and studied by Odo Diekmann and his collaborators. In this essay I argue for taking the properties that led to these successes as the defining characteristics of the concept of individual, delegating the properties classically invoked by philosophers to the secondary role of possible empirical indicators for the presence of those characteristics. The essay starts with putting in place as rule for effective concept engineering that one should go for relations that can be used as basis for deductive structure building rather than for perceived ontological essence. By analysing how we want to use it in the mathematical arguments I then build up a concept of individual, first for use in population dynamical considerations and then for use in evolutionary ones. These two concepts do not coincide, and neither do they on all occasions agree with common intuition-based usage.
Zhang, W N; Xiao, H J; Liang, G M; Guo, Y Y; Wu, K M
2014-08-01
Evolution of resistance to insecticides usually has fitness tradeoffs associated with adaptation to the stress. The basic regulation mechanism of tradeoff between reproduction and resistance evolution to Bacillus thuringiensis (Bt) toxin in the cotton bollworm, Helicoverpa armigera (Ha), based on the vitellogenin (Vg) gene expression was analyzed here. The full-length cDNA of the Vg gene HaVg (JX504706) was cloned and identified. HaVg has 5704 base pairs (bp) with an open reading frame (ORF) of 5265 bp, which encoded 1756 amino acid protein with a predicted molecular mass of 197.28 kDa and a proposed isoelectric point of 8.74. Sequence alignment analysis indicated that the amino acid sequence of HaVg contained all of the conserved domains detected in the Vgs of the other insects and had a high similarity with the Vgs of the Lepidoptera insects, especially Noctuidae. The resistance level to Cry1Ac Bt toxin and relative HaVg mRNA expression levels among the following four groups: Cry1Ac-susceptible strain (96S), Cry1Ac-resistant strain fed on artificial diet with Bt toxin for 135 generations (BtR stands for the Cry1Ac Bt resistance), progeny of the Cry1Ac-resistant strain with a non-Bt-toxin artificial diet for 38 generations (CK1) and the direct descendants of the 135th-generation resistant larvae which were fed on an artificial diet without the Cry1Ac protein (CK2) were analyzed. Compared with the 96S strain, the resistance ratios of the BtR strain, the CK1 strain and the CK2 strain were 2917.15-, 2.15- and 2037.67-fold, respectively. The maximum relative HaVg mRNA expression levels of the BtR strain were approximately 50% less than that of the 96S strain, and the coming of maximum expression was delayed for approximately 4 days. The overall trend of the HaVg mRNA expression levels in the CK1 strain was similar to that in the 96S strain, and the overall trend of the HaVg mRNA expression levels in the CK2 strain was similar to that in the BtR strain. Our results suggest that the changes in reproduction due to the Bt-toxin resistance evolution in the BtR strain may be regulated by the Vg gene expression. The down-regulation of HaVg at the early stages resulted in a period of delayed reproduction and decreased fecundity in the BtR strain. This performance disappeared when the Bt-toxin selection pressure was lost.
Johnson, Jani A; Xu, Jingjing; Cox, Robyn M
2016-01-01
Modern hearing aid (HA) devices include a collection of acoustic signal-processing features designed to improve listening outcomes in a variety of daily auditory environments. Manufacturers market these features at successive levels of technological sophistication. The features included in costlier premium hearing devices are designed to result in further improvements to daily listening outcomes compared with the features included in basic hearing devices. However, independent research has not substantiated such improvements. This research was designed to explore differences in speech-understanding and listening-effort outcomes for older adults using premium-feature and basic-feature HAs in their daily lives. For this participant-blinded, repeated, crossover trial 45 older adults (mean age 70.3 years) with mild-to-moderate sensorineural hearing loss wore each of four pairs of bilaterally fitted HAs for 1 month. HAs were premium- and basic-feature devices from two major brands. After each 1-month trial, participants' speech-understanding and listening-effort outcomes were evaluated in the laboratory and in daily life. Three types of speech-understanding and listening-effort data were collected: measures of laboratory performance, responses to standardized self-report questionnaires, and participant diary entries about daily communication. The only statistically significant superiority for the premium-feature HAs occurred for listening effort in the loud laboratory condition and was demonstrated for only one of the tested brands. The predominant complaint of older adults with mild-to-moderate hearing impairment is difficulty understanding speech in various settings. The combined results of all the outcome measures used in this research suggest that, when fitted using scientifically based practices, both premium- and basic-feature HAs are capable of providing considerable, but essentially equivalent, improvements to speech understanding and listening effort in daily life for this population. For HA providers to make evidence-based recommendations to their clientele with hearing impairment it is essential that further independent research investigates the relative benefit/deficit of different levels of hearing technology across brands and manufacturers in these and other real-world listening domains.
David Hulse; Allan Branscomb; Chris Enright; Bart Johnson; Cody Evers; John Bolte; Alan Ager
2016-01-01
This article offers a literature-supported conception and empirically grounded analysis of surprise by exploring the capacity of scenario-driven, agent-based simulation models to better anticipate it. Building on literature-derived definitions and typologies of surprise, and using results from a modeled 81,000 ha study area in a wildland-urban interface of western...
USDA-ARS?s Scientific Manuscript database
Aluminum-based water treatment residuals (Al-WTR) have a strong affinity to sorb phosphorus. In a proof-of-concept greenhouse column study, Al-WTR was surface-applied at 0, 62, 124, and 248 Mg/ha to 15 cm of soil on top of 46 cm of sand; Al-WTR rates were estimated to capture 0, 10, 20, and 40 year...
Report of the Defense Science Board Task Force on Nuclear Deterrence Skills
2008-09-01
entail modeling and simulation capability analogous to that for weapon design. A minimum “national” nuclear weapons effects simulator enterprise...systems programs (design, develop, produce, deploy, and sustain) relies 18 I C HA P TE R 3 upon a variety of management models . For example, the Air...entry vehicle design, modeling and simulation efforts, command and control, launch system infrastructure, intermediate-range missile concepts, advanced
Machine to harvest slash, brush, and thinnings for fuel and fiber - a concept
Peter Koch; Dan W. McKenzie
1976-01-01
It is proposed that biomass from non-commercial thinnings, and from logging slash residual after harvest, be lhogged and recovered for fuel and fiber. Such a procedure might yield two dividends of biomass totalling as much as 90,000 kg per ha (40 tons per acre, gree weight basis) from each rotation of southern pine. For sites deficient in organic matter, it is...
Advanced electric propulsion system concept for electric vehicles
NASA Technical Reports Server (NTRS)
Raynard, A. E.; Forbes, F. E.
1979-01-01
Seventeen propulsion system concepts for electric vehicles were compared to determine the differences in components and battery pack to achieve the basic performance level. Design tradeoffs were made for selected configurations to find the optimum component characteristics required to meet all performance goals. The anticipated performance when using nickel-zinc batteries rather than the standard lead-acid batteries was also evaluated. The two systems selected for the final conceptual design studies included a system with a flywheel energy storage unit and a basic system that did not have a flywheel. The flywheel system meets the range requirement with either lead-acid or nickel-zinc batteries and also the acceleration of zero to 89 km/hr in 15 s. The basic system can also meet the required performance with a fully charged battery, but, when the battery approaches 20 to 30 percent depth of discharge, maximum acceleration capability gradually degrades. The flywheel system has an estimated life-cycle cost of $0.041/km using lead-acid batteries. The basic system has a life-cycle cost of $0.06/km. The basic system, using batteries meeting ISOA goals, would have a life-cycle cost of $0.043/km.
Teaching microbiology to undergraduate students in the humanities and the social sciences.
Oren, Aharon
2015-10-01
This paper summarizes my experiences teaching a 28-hour course on the bacterial world for undergraduate students in the humanities and the social sciences at the Hebrew University of Jerusalem. This course was offered in the framework of a program in which students must obtain credit points for courses offered by other faculties to broaden their education. Most students had little biology in high school and had never been exposed to the basics of chemistry. Using a historical approach, highlighting the work of pioneers such as van Leeuwenhoek, Koch, Fleming, Pasteur, Winogradsky and Woese, I covered a broad area of general, medical, environmental and evolutionary microbiology. The lectures included basic concepts of organic and inorganic chemistry necessary to understand the principles of fermentations and chemoautotrophy, and basic molecular biology to explain biotechnology using transgenic microorganisms and molecular phylogeny. Teaching the basics of microbiology to intelligent students lacking any background in the natural sciences was a rewarding experience. Some students complained that, in spite of my efforts, basic concepts of chemistry remained beyond their understanding. But overall the students' evaluation showed that the course had achieved its goal. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Using Discrepant Events to Inspire Writing.
ERIC Educational Resources Information Center
Ruck, Carolyn; And Others
1991-01-01
Demonstrations that can be used to lead students to wonder and write about basic scientific principles are presented. Each demonstration includes the concept demonstrated, a list of materials, and procedures. Concepts include density and temperature of liquids, contracting matter with heat, atmospheric pressure, dramatic color changes, fireproof…
Teaching Through Adventure: A Practical Approach.
ERIC Educational Resources Information Center
1976
Presenting four basic adventure education concepts as defined by Project Adventure (a Demonstrator/Developer Project within the National Diffusion Network and operating out of Massachusetts), this book describes a number of successful high school and middle high adventure programs. Major adventure education concepts are identified as: adventure…
Rethinking Recycling: Why Teach about Garbage?
ERIC Educational Resources Information Center
Clearing, 1993
1993-01-01
Ties environmental education, via garbage disposal issues, to Oregon's educational reform agenda. Discusses teaching the basics through "garbage" lessons. Includes how to (1) take an interdisciplinary approach; (2) introduce waste management concepts in other lessons; (3) use waste management examples to apply existing concepts; and (4)…
Knowledge of the brain-death concept among secondary school teachers.
Ríos, A; Febrero, B; López-Navas, A; Martínez-Alarcón, L; Sánchez, J; Guzmán, D; Ramírez, P; Parrilla, P
2012-01-01
The concept of brain death (BD) is not very well known in the population, and its unknown nature is one of the main factors that could lead to an attitude against organ donation. The teaching sector has an important influence on the education of adolescents, and for this reason the teacher's knowledge of these concepts is fundamental to spread the correct meaning of the concept to young people. To analyze the concept of BD among teachers of compulsory secondary education (CSE) in southeast Spain and to determine teachers' influence on attitude toward organ donation. Ten CSE level schools were selected and stratified according to geographical location in southeast spain. A random sample was taken of CSE teachers. The knowledge of the concept of BD and attitude toward donation were analyzed using a validated questionnaire, which was self-administered and completed anonymously. Sixty-four percent (n = 180) of respondents knew the BD concept and they considered it to be the death of an individual. Of the rest, 34% (n = 95) did not know this concept, and the remaining 3% (n = 8) believed it did not mean a person's death. Those who understood the concept of BD were more in favor of deceased donation than those who held the wrong concept (82% versus 75%; P < .01). The knowledge of the concept of BD is associated with variables directly and indirectly related with donation and transplantation (P < .05). A third of the CSE teaching staff did not know or understand the BD concept as the death of an individual. The knowledge of BD positively affects attitude toward organ donation. Given that teachers are a source of information, the basic training of CSE teaching staff in basic concepts such as BD would be important. Copyright © 2012 Elsevier Inc. All rights reserved.
Project BASIC: Building Art Systems into Curriculum.
ERIC Educational Resources Information Center
Benson, Cal; Doane, Mitzi
1982-01-01
Describes Duluth, Minnesota's interdisciplinary program, Project BASIC, which incorporates five major art forms into the elementary curriculum. Schools employ artists-in-residence and in-service training to expand teacher use of arts in the classroom. Results of a research study to measure gains in self-concept and creativity are included. (AM)
How to Add Philosophy Dimensions in Your Basic International Business Course
ERIC Educational Resources Information Center
Thanopoulos, John
2010-01-01
This article aims to assist professors in introducing concepts of self, philosophy, religions, the universe, existential dilemmas, etc., in their basic international business classes. Using active learning and five-member student teams, a student organized and administered conference adds a very useful dimension of knowledge sacrificing only one…
Using Scientific and Industrial Films in Teaching Technical Communication.
ERIC Educational Resources Information Center
Veeder, Gerry
A film course especially designed for technical communication students can illustrate basic film concepts and techniques while showing how film effectively communicates ideas in an industrial and scientific communication system. After a basic introduction to film terms, the study of actual scientific and industrial films demonstrates the following…
Alfred-Adler's Basic Concepts and Implications.
ERIC Educational Resources Information Center
Lundin, Robert W.
This book presents the basic principles of Adler's psychology. The first chapter looks at Adlerian psychology as it exists today, and examines earlier influences. The second chapter examines feelings of inferiority and compensation for these feelings. The third chapter considers the nature of goals and how they are formulated. The fourth chapter…
Diesel Mechanics: Fundamentals.
ERIC Educational Resources Information Center
Foutes, William; And Others
This publication is the first in a series of three texts for a diesel mechanics curriculum. Its purpose is to teach the basic concepts related to employment in a diesel trade. Six sections contain 29 units. Each instructional unit includes some or all of these basic components: unit and specific (performance) objectives, suggested activities for…
Basic Curriculum Guide--Science. Grades K-6.
ERIC Educational Resources Information Center
Starr, John W., 3rd., Ed.
GRADES OR AGES: K-6. SUBJECT MATTER: Science. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is in two parts--the background, philosophy, and instructional principles of science teaching, including a resource unit model, and the development by grade level of the various basic scientific concepts. The guide also includes information of…
A Primer on Sampling for Statewide Assessment.
ERIC Educational Resources Information Center
Jaeger, Richard M.
This paper is a primer on sampling procedures for statewide assessment. The careful reader should gain substantial knowledge about the promises and pitfalls of sampling for assessment. The primer has three basic objectives: (1) to define terms and concepts basic to sampling theory and its application, including population, sampling unit, sampling…
Geometric Error Analysis in Applied Calculus Problem Solving
ERIC Educational Resources Information Center
Usman, Ahmed Ibrahim
2017-01-01
The paper investigates geometric errors students made as they tried to use their basic geometric knowledge in the solution of the Applied Calculus Optimization Problem (ACOP). Inaccuracies related to the drawing of geometric diagrams (visualization skills) and those associated with the application of basic differentiation concepts into ACOP…
Life Management Skills, 8230. Home Economics Education.
ERIC Educational Resources Information Center
Loudoun County Public Schools, Leesburg, VA.
The middle school home economics curriculum on Life Management Skills I (eighth grade) meets the needs of the early adolescent. It is based upon three major concepts: (1) basic skills; (2) self-knowledge/understanding/decision making; and (3) independence/interdependence. Emphasis on the basic skills of reading, writing, communicating, using…
Using Personal Narratives to Incorporate Diversity into the Basic Communication Course.
ERIC Educational Resources Information Center
Rozema, Hazel
Arguing that first-person narratives can illustrate communication theories and concepts found throughout basic communication course texts and can serve as first-person examples of the effects of racism and stereotyping, this paper summarizes two "powerful and engaging" texts that illustrate the standpoint of African-Americans in the…
The Stock Market and Economic Principles: A Curriculum Project.
ERIC Educational Resources Information Center
Savino, Ronald J.
This paper outlines how to teach macroeconomic principles through mock stock market investing while helping students develop economic awareness, interest, and comprehension on a more sophisticated level. The basic textbook is "The Economy Today" (B. R. Schiller). After two weeks of teaching basic economic concepts and vocabulary, such as…
Integration of Basic Sciences in Health's Courses
ERIC Educational Resources Information Center
Azzalis, L. A.; Giavarotti, L.; Sato, S. N.; Barros, N. M. T.; Junqueira, V. B. C.; Fonseca, F. L. A.
2012-01-01
Concepts from disciplines such as Biochemistry, Genetics, Cellular and Molecular Biology are essential to the understanding and treatment of an elevated number of illnesses, but often they are studied separately, with no integration between them. This article proposes a model for basic sciences integration based on problem-based learning (PBL) and…
ERIC Educational Resources Information Center
Weaver, Kari D.; Pier, Penni M.
2010-01-01
This article explores the process of embedding information literacy into a basic oral communication course. Discussion includes student performance as an impetus for change, collaborative course design between the oral communication teaching team and instructional librarians, and assessment initiatives. Suggestions for future collaborative work…
Lunar interferometric astronomy: Some basic questions
NASA Technical Reports Server (NTRS)
Woolf, Neville
1992-01-01
The author examines some basic questions as to why there should be astronomical facilities on the far side of the moon. The questions are ones of appropriateness, i.e., is this a proper use for human resources, what the real goals are, and are the present concepts the best match for the goals.
Project Logic Handbook: Computer Literacy through BASIC.
ERIC Educational Resources Information Center
Huber, Leonard; And Others
This handbook for teachers offers guidance on introducing computer literacy into elementary and secondary classrooms. It includes a list of computer concepts exemplified by each step in learning to write programs in BASIC Programming Language and the objectives for the elementary and secondary activities; suggestions for using computers in…
ERIC Educational Resources Information Center
Harrell, John
Intended as a guide to the use of different media for use in the classroom, this document demonstrates alternative approaches that may be taken to depicting and communicating images and concepts to others. Some basic tools and materials--including a ruler, matte knife, rubber cement, stapler, felt-tip pens, paint brushes, and lettering pens--are…
Teaching Basic Quantum Mechanics in Secondary School Using Concepts of Feynman Path Integrals Method
ERIC Educational Resources Information Center
Fanaro, Maria de los Angeles; Otero, Maria Rita; Arlego, Marcelo
2012-01-01
This paper discusses the teaching of basic quantum mechanics in high school. Rather than following the usual formalism, our approach is based on Feynman's path integral method. Our presentation makes use of simulation software and avoids sophisticated mathematical formalism. (Contains 3 figures.)
Play Therapy: Basics and Beyond.
ERIC Educational Resources Information Center
Kottman, Terry
This book provides an atheoretical orientation to basic concepts involved in play therapy and an introduction to different skills used in play therapy. The demand for mental professionals and school counselors who have training and expertise in using play as a therapeutic tool when working with children has increased tremendously. In response to…
Basic Electricity. Training Module 3.325.1.77.
ERIC Educational Resources Information Center
Kirkwood Community Coll., Cedar Rapids, IA.
This document is an instructional module package prepared in objective form for use by an instructor familiar with the basic concepts of electricity as applied to water and wastewater treatment. Included are objectives, instructor guides, student handouts, and transparency masters. This module considers definition of terms, voltage, current…
ERIC Educational Resources Information Center
Stefani, Christina; Tsaparlis, Georgios
2009-01-01
We investigated students' knowledge constructions of basic quantum chemistry concepts, namely atomic orbitals, the Schrodinger equation, molecular orbitals, hybridization, and chemical bonding. Ausubel's theory of meaningful learning provided the theoretical framework and phenomenography the method of analysis. The semi-structured interview with…
Suggestions for Realization Rather than Professionalization in Adult Basic Education.
ERIC Educational Resources Information Center
Allen, Fred
1987-01-01
A literature review shows lack of consensus in defining adult education and rejection of the application of the traditional model of professionalism to adult basic education (ABE). Carl Rogers' concept of substituting realization for professionalization, as well as the literature of staff preservice and inservice training, can help practitioners…
JSC interactive basic accounting system
NASA Technical Reports Server (NTRS)
Spitzer, J. F.
1978-01-01
Design concepts for an interactive basic accounting system (IBAS) are considered in terms of selecting the design option which provides the best response at the lowest cost. Modeling the IBAS workload and applying this workload to a U1108 EXEC 8 based system using both a simulation model and the real system is discussed.
Project Trade Related Reading Packets for Disabled Readers. Final Report 1984-85.
ERIC Educational Resources Information Center
Davis, Beverly; Woodruff, Nancy S.
A comprehensive, shop-related curriculum was developed for special needs students who are severely disabled readers. The basic approach of the curriculum was to provide individualized diagnostic-prescriptive materials that correlate basic reading skills and the required vocational and technical concepts. Trade-related packets were written for…
Developing More Effective Curriculum Via "Basic Stuff."
ERIC Educational Resources Information Center
Heitmann, Helen M.
Discussed is the design and development of a physical education curriculum, incorporating principles discussed in the "Basic Stuff" physical education series. Four tasks are suggested for planning the curriculum: (1) develop a unit for activity instruction, where the concepts inherent in the sport or activity skills may be identified; (2) develop…
ERIC Educational Resources Information Center
Freeman, Robert E.
Advocates of the new social studies have long urged the use of concepts as the basic building blocks in social studies. The question of what concepts and definitions of them should be taught is a matter of agreement among qualified judges. As qualified judges in the international relations-war/peace international education field, we can determine…
ERIC Educational Resources Information Center
Patil, Rajan R.
2011-01-01
Epidemiology is a difficult but an important subject in public health curriculum. As teachers, we need to be very innovative in teaching the core concepts in epidemiology since it is basically a research oriented subject that calls for enormous application of logic and mathematical skills. Very often, complex epidemiological concepts need to be…
ERIC Educational Resources Information Center
Dixon, Ford
This guide will help teachers of grades 6-12 integrate economics concepts into history courses. The developers believe that the language and theories of economics are more understandable, germane, and pertinent in the context of a history curriculum. The seven basic economic concepts taught are: the law of demand, the law of supply, private…
Educational Intervention in a Medically Underserved Area.
Atance, Joel; Mickalis, Morgan; Kincade, Brianna
2018-04-01
Medical students from rural and medically underserved areas (MUAs) are more likely than their peers to practice medicine in rural areas and MUAs. However, students from MUAs are also more likely to face socioeconomic barriers to a career in medicine. To determine whether a week-long summer enrichment experience (SEE) at Edward Via College of Osteopathic Medicine-Carolinas could successfully teach high school students from MUAs basic biomedical concepts and foster an interest in medicine and the health sciences. The SEE program is open to high school students in the Spartanburg, South Carolina, area. The program includes interactive lectures, laboratories, demonstrations on gross anatomy prosections, demonstrations on medical simulation models, tours of emergency vehicles, an introduction to osteopathic manipulative medicine, and student-led research projects. Participants were asked to complete a 15-question quiz that assessed their knowledge of basic biomedical concepts and a 10-question survey that assessed their attitudes toward careers in medicine and health sciences. Both the quiz and the survey were completed on both the first and final days of the program. The data were analyzed using paired t tests. Participant knowledge of basic biomedical concepts, as determined by the quiz scores, increased after completion of the program (9.1 average correct answers vs 12.6 average correct answers) (P<.001). Participant attitude toward medicine and the health sciences improved in 9 of the 10 items surveyed after completion of the program (P<.05). Participant knowledge of basic biomedical concepts and their knowledge of and interest in careers in the health sciences improved after completing the SEE program. These findings suggest that educational interventions for high school students could help to develop primary care physicians for rural areas and MUAs and that there is a role for osteopathic medical schools to nurture these students as early as possible.
Mental Capacity Act 2005: statutory principles and key concepts.
Griffith, Richard; Tengnah, Cassam
2008-05-01
The Mental Capacity Act 2005 represents the most significant development in the law relating to people who lack decision making capacity since the Mental Health Act 1959 removed the states parens patriae jurisdiction preventing relatives, courts and government bodies consenting on behalf of incapable adults (F vs West Berkshire HA [1990]). The Mental Capacity Act 2005 impacts on the care and treatment provided by district nurses and it is essential that you have a sound working knowledge of its provisions and code of practice. In the first article of a series focusing on how the Mental Capacity Act 2005 applies to district nurse practice, Richard Griffith and Cassam Tengnah consider the principles and key concepts underpinning the Act.
Lofthus, Ann-Mari; Westerlund, Heidi; Bjørgen, Dagfinn; Lindstrøm, Jonas Christoffer; Lauveng, Arnhild; Rose, Diana; Ruud, Torleif; Heiervang, Kristin
2018-02-01
Recovery is a crucial concept in the mental health field. The research of recovery is split into the categories of personal, social and clinical recovery. The purpose of this study was to explore the fragmented concept of recovery in light of assertive community treatment (ACT) in Norway. The study has a mixed methods design with a pragmatic approach. The Questionnaire about the Process of Recovery and open-ended questions posed to 70 participants from 12 ACT teams in Norway, gathered by the "Users interview users" method, are combined with interviews or focus groups with eight of these participants. Surprisingly those under a community treatment order (CTO) report the highest degree of personal recovery. The qualitative material shows that the service users interpreted the concept of recovery differently than researchers and professionals. The ACT service users highlighted three important elements: flexible treatment, medication and access to a car. They emphasized the necessity for basic needs to be met in order to experience a meaningful recovery process, and these basic needs may be of even greater importance to those under CTOs. Their experiences should imply a greater emphasis on securing basic needs such as secure housing, sounder finances and access to the normal benefits offered by society. © 2016 Australian College of Mental Health Nurses Inc.
White light Sagnac interferometer—a common (path) tale of light
NASA Astrophysics Data System (ADS)
Schwartz, Eyal
2017-11-01
White or polychromatic light sources are vastly abundant in nature and lie in our most basic understanding of the theory of light, beginning from stars like our Sun and extending to every common household light bulb or street lamp. In this paper, I present concepts of white light interferometery using a common-path Sagnac interferometer, manifested in a straightforward laboratory experiment. I further show the use of this as a Fourier transform spectrometer while presenting a basic overview of the theoretical concepts and spectrum of different light sources obtained experimentally. This work, both experimentally and analytically, is suitable for upper-level undergraduate physics or engineering courses where electromagnetic theory and optics are discussed. The experiment and theory presents important deep concepts and aspects in modern optics and physics that every science student should acquire.
Endoradiotherapy in cancer treatment--basic concepts and future trends.
Zoller, Frederic; Eisenhut, Michael; Haberkorn, Uwe; Mier, Walter
2009-12-25
Endoradiotherapy represents an alternative therapeutic method in cancer treatment with advantageous features compared to chemotherapy and radiation therapy. Intelligent dose delivery concepts using small drugs, peptides or antibodies as radionuclide carriers enable the verification of a selective accumulation in the tumour lesion and to reduce radiation toxicity for the peripheral organs. The development of endoradiotherapeutic agents, especially chelator-conjugated biomolecules, for example ibritumomab tiuxetan or DOTATOC, gains importance due to the stable complexation of versatile radiometals, such as (90)Y or (177)Lu. The rational design of novel target binding sides and their grafting into a drug scaffold is a highly promising strategy, which may promote further implication in endoradiotherapy. This review highlights the basic concepts of endoradiotherapy and discusses the potential of targeted therapy and the properties of energy-rich particles emitted by radionuclides for tumour therapy.
Advanced Placement Economics. Macroeconomics: Student Activities.
ERIC Educational Resources Information Center
Morton, John S.
This book is designed to help advanced placement students better understand macroeconomic concepts through various activities. The book contains 6 units with 64 activities, sample multiple-choice questions, sample short essay questions, and sample long essay questions. The units are entitled: (1) "Basic Economic Concepts"; (2) "Measuring Economic…
A Primer on Adventure Education in the Camp Setting.
ERIC Educational Resources Information Center
Nei, Eric
2003-01-01
Basic concepts of experiential learning theory are presented to assist camp directors in choosing knowledgeable staff and developing successful adventure programs. These concepts include assessment of learner (camper) readiness, activity sequencing, learning cycle, comfort zone, activity framing, task goals versus process goals, and five stages of…
Located in the Thin of It: Young Children's Use of Thin Moral Concepts
ERIC Educational Resources Information Center
Wright, Jennifer Cole; Sedlock, Trisha; West, Jenny; Saulpaugh, Kelly; Hopkins, Michelle
2016-01-01
One important socio-cultural medium through which young children's moral understanding is cultivated is parent/child discourse. Of particular interest to us was young children's use of basic ("thin") evaluative concepts ("good," "bad," "right" and "wrong"), which are ubiquitous in everyday…
Citizen Me: An Experiential Curriculum for Citizenship Education. Level: Five.
ERIC Educational Resources Information Center
Gutierrez, Merri
Integrating concepts of basic citizenship education with community involvement, this experiential curriculum provides a means for developing decision making and critical thinking skills within the existing fifth grade social studies curriculum. The 12 lessons cover the following concepts: responsibilities, rules and laws, involvement vs.…
Computer Systems for Teaching Complex Concepts.
ERIC Educational Resources Information Center
Feurzeig, Wallace
Four Programing systems--Mentor, Stringcomp, Simon, and Logo--were designed and implemented as integral parts of research into the various ways computers may be used for teaching problem-solving concepts and skills. Various instructional contexts, among them medicine, mathematics, physics, and basic problem-solving for elementary school children,…
Marketing Continuing Education for Nurses.
ERIC Educational Resources Information Center
Southern Regional Education Board, Atlanta, GA.
This guide presents an overview of marketing and its potential value in continuing education programs for nurses. The first portion of the guide briefly discusses the concept of marketing. It contains definitions of key marketing concepts (product, place, price, and promotion), discussion of the basic tenets of marketing (consumer needs…
Soapy Science. Teaching Science.
ERIC Educational Resources Information Center
Leyden, Michael
1997-01-01
Describes a science and math activity that involves bubbles, shapes, colors, and solid geometry. Students build geometric shapes with soda straws and submerge the shapes in soapy water, allowing them to review basic geometry concepts, test hypotheses, and learn about other concepts such as diffraction, interference colors, and evaporation. (TJQ)
Basic Writing Concepts for Scientists and Engineers.
ERIC Educational Resources Information Center
Mitchell, John H.
1980-01-01
Notes the differences between poetry and technical communication. Charges English teacher/humanists with confusing students about emotional writing, style, and effective technical communication. Offers five concepts that technical writing teachers can use to place "style" on a rational basis and to make students understand the true purposes of…
Testing fundamental ecological concepts with a Pythium-Prunus pathosystem
USDA-ARS?s Scientific Manuscript database
The study of plant-pathogen interactions has enabled tests of basic ecological concepts on plant community assembly (Janzen-Connell Hypothesis) and plant invasion (Enemy Release Hypothesis). We used a field experiment to (#1) test whether Pythium effects depended on host (seedling) density and/or d...
Chemistry Students' Erroneous Conceptions of Limiting Reagent.
ERIC Educational Resources Information Center
Mammen, K. J.
1996-01-01
Describes a study of 32 University of Transkei (South Africa) freshmen's conceptualization of "limiting reagent," a basic concept in chemistry, based on student responses to two written test questions and clinical interviews. Results indicated that a high percentage of students had misconceptions and could not apply the concept…
A Pilot Study on the Perception of Innovation and Entrepreneurship
ERIC Educational Resources Information Center
Aslan, A. Esra; Duman, Burcu; Sen, Dunya; Duran, Cem; Atarbay, Sinem
2016-01-01
Problem Statement: The concepts of innovation and entrepreneurship must be understood and adopted to ensure such transformation in the university after "Entrepreneurial and Innovative University Index" publication. The basic problem of this research is an analysis of how entrepreneurs define the concepts of innovation and…
ERIC Educational Resources Information Center
VanCleave, Janice
This book provides opportunities for engaging students in scientific investigations, offering a hands-on approach that encourages students to understand science concepts, gives them ways to apply the concepts, and introduces and reinforces the skills they need to become independent investigators. The basic outline and objectives of each section of…
American Indian Religion: Past, Present, Future.
ERIC Educational Resources Information Center
Stewart, Omer C.
1980-01-01
Describes the basic concept of American Indian religion after briefly comparing fundamental religious concepts of several civilizations. Discusses the historical and current roles of medicine men, the belief in supernatural forces, the effect of missionary zeal on American Indian religions, and the appearance of Christian elements in traditional…
Prospective Science Teachers' Conceptions about Astronomical Subjects
ERIC Educational Resources Information Center
Küçüközer, Hüseyin
2007-01-01
The main objective of this study was to identify prospective science teachers' conceptions on basic astronomical phenomena. A questionnaire consisting of nine open-ended questions was administered to 327 prospective science teachers. The questionnaire was constructed after extensive review of the literature and took into consideration the reported…
Learning Information Systems: Theoretical Foundations.
ERIC Educational Resources Information Center
Paul, Terrance D.
This paper uses the conceptual framework of cybernetics to understand why learning information systems such as the "Accelerated Reader" work so successfully, and to examine how this simple yet incisive concept can be used to accelerate learning at every level and in all disciplines. The first section, "Basic Concepts,"…
Logistic Regression: Concept and Application
ERIC Educational Resources Information Center
Cokluk, Omay
2010-01-01
The main focus of logistic regression analysis is classification of individuals in different groups. The aim of the present study is to explain basic concepts and processes of binary logistic regression analysis intended to determine the combination of independent variables which best explain the membership in certain groups called dichotomous…
ERIC Educational Resources Information Center
Williams, Immanuel James; Williams, Kelley Kim
2016-01-01
Understanding summary statistics and graphical techniques are building blocks to comprehending concepts beyond basic statistics. It's known that motivated students perform better in school. Using examples that students find engaging allows them to understand the concepts at a deeper level.
The Well-being Conception of Health and the Conflation Problem.
de Campos, Thana C
2016-04-01
Human rights advocates often use inflated and thus underspecified terminologies when addressing the content of their claims. One example of such loose terminology is the term 'well-being', as currently employed in connection with a definition for the right to health. What I call the 'well-being conception of health' conflates the distinct ideas of basic and non-basic health needs, as well as those of individual autonomy and freedom. I call this the conflation problem. This paper argues for the need of an understanding of the right to health, nuanced enough to capture not only these distinct ideas, but also their moral relevance for the common good.
DOE Fundamentals Handbook: Mathematics, Volume 1
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1992-06-01
The Mathematics Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of mathematics and its application to facility operation. The handbook includes a review of introductory mathematics and the concepts and functional use of algebra, geometry, trigonometry, and calculus. Word problems, equations, calculations, and practical exercises that require the use of each of the mathematical concepts are also presented. This information will provide personnel with a foundation for understanding and performing basic mathematical calculations that are associated with various DOE nuclearmore » facility operations.« less
DOE Fundamentals Handbook: Mathematics, Volume 2
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1992-06-01
The Mathematics Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of mathematics and its application to facility operation. The handbook includes a review of introductory mathematics and the concepts and functional use of algebra, geometry, trigonometry, and calculus. Word problems, equations, calculations, and practical exercises that require the use of each of the mathematical concepts are also presented. This information will provide personnel with a foundation for understanding and performing basic mathematical calculations that are associated with various DOE nuclearmore » facility operations.« less
Basic principles of test-negative design in evaluating influenza vaccine effectiveness.
Fukushima, Wakaba; Hirota, Yoshio
2017-08-24
Based on the unique characteristics of influenza, the concept of "monitoring" influenza vaccine effectiveness (VE) across the seasons using the same observational study design has been developed. In recent years, there has been a growing number of influenza VE reports using the test-negative design, which can minimize both misclassification of diseases and confounding by health care-seeking behavior. Although the test-negative designs offer considerable advantages, there are some concerns that widespread use of the test-negative design without knowledge of the basic principles of epidemiology could produce invalid findings. In this article, we briefly review the basic concepts of the test-negative design with respect to classic study design such as cohort studies or case-control studies. We also mention selection bias, which may be of concern in some countries where rapid diagnostic testing is frequently used in routine clinical practices, as in Japan. Copyright © 2017. Published by Elsevier Ltd.
Methods of training the graduate level and professional geologist in remote sensing technology
NASA Technical Reports Server (NTRS)
Kolm, K. E.
1981-01-01
Requirements for a basic course in remote sensing to accommodate the needs of the graduate level and professional geologist are described. The course should stress the general topics of basic remote sensing theory, the theory and data types relating to different remote sensing systems, an introduction to the basic concepts of computer image processing and analysis, the characteristics of different data types, the development of methods for geological interpretations, the integration of all scales and data types of remote sensing in a given study, the integration of other data bases (geophysical and geochemical) into a remote sensing study, and geological remote sensing applications. The laboratories should stress hands on experience to reinforce the concepts and procedures presented in the lecture. The geologist should then be encouraged to pursue a second course in computer image processing and analysis of remotely sensed data.
[Introduction to Exploratory Factor Analysis (EFA)].
Martínez, Carolina Méndez; Sepúlveda, Martín Alonso Rondón
2012-03-01
Exploratory Factor Analysis (EFA) has become one of the most frequently used statistical techniques, especially in the medical and social sciences. Given its popularity, it is essential to understand the basic concepts necessary for its proper application and to take into consideration the main strengths and weaknesses of this technique. To present in a clear and concise manner the main applications of this technique, to determine the basic requirements for its use providing a description step by step of its methodology, and to establish the elements that must be taken into account during its preparation in order to not incur in erroneous results and interpretations. Narrative review. This review identifies the basic concepts and briefly describes the objectives, design, assumptions, and methodology to achieve factor derivation, global adjustment evaluation, and adequate interpretation of results. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.
Introduction to Concepts in Artificial Neural Networks
NASA Technical Reports Server (NTRS)
Niebur, Dagmar
1995-01-01
This introduction to artificial neural networks summarizes some basic concepts of computational neuroscience and the resulting models of artificial neurons. The terminology of biological and artificial neurons, biological and machine learning and neural processing is introduced. The concepts of supervised and unsupervised learning are explained with examples from the power system area. Finally, a taxonomy of different types of neurons and different classes of artificial neural networks is presented.
Cultural Influences on Intertemporal Reasoning: An Annotated Bibliography
2011-11-30
International Conference on Cross- Cultural Decision Making, Miami, FL.5 MacGregor, D. G., & Godfrey, J. (2011, February). Observations on the Concept of Risk...encounter with an Arab culture , or to be better prepared after their first encounter. The focus is a great deal of basic cultural concepts ...workers, visitors and telephone). (Note: The concept of polychronic and monochromic cultures was originally advanced by Edward Hall in his book, The
Introducing Disjoint and Independent Events in Probability.
ERIC Educational Resources Information Center
Kelly, I. W.; Zwiers, F. W.
Two central concepts in probability theory are those of independence and mutually exclusive events. This document is intended to provide suggestions to teachers that can be used to equip students with an intuitive, comprehensive understanding of these basic concepts in probability. The first section of the paper delineates mutually exclusive and…
Teaching through Trade Books: You Light up My Life
ERIC Educational Resources Information Center
Royce, Christine Anne
2016-01-01
The abstract nature of physical science concepts often means that they are the most challenging for elementary students to grasp. Understanding how light behaves allows students to form a foundation for their future understanding. This month's trade books and activities engage students in basic concepts related to light.
DOT National Transportation Integrated Search
1978-05-01
The purpose of this study is to provide an independent identification, classification, and analysis of significant freight car coupling system concepts offering potential for improved safety and operating costs over the present system. The basic meth...
Energy Relations in Russia: Administration, Politics and Security
ERIC Educational Resources Information Center
Makarychev, Andrey
2005-01-01
This chapter analyses energy relations through a prism of three interlinked concepts: administration, politics and security. This triad describes the basic approaches to questions about technical, politicised and securitised energy. These three concepts are logically linked to one another and represent an elementary matrix; a prism through which…
Teaching for Conceptual Change in Space Science
ERIC Educational Resources Information Center
Brunsell, Eric; Marcks, Jason
2007-01-01
Nearly 20 years after the release of The Harvard-Smithsonian Center for Astrophysics' video, "A Private Universe", much research has been done in relation to students' understanding of space-science concepts and how to effectively change these ideas. However, student difficulties with basic space-science concepts still persist. This article will…
DOT National Transportation Integrated Search
1978-05-01
The purpose of this study is to provide an independent identification, classification, and analysis of significant freight car coupling systems concepts offering potential for improved safety and operating costs over the present system. The basic met...
Mathematical Language Skills of Mathematics Prospective Teachers
ERIC Educational Resources Information Center
Gürefe, Nejla
2018-01-01
Effective mathematics teaching can be actualized only with correct use of the mathematical content language which comprises mathematical rules, concepts, symbols and terms. In this research, it was aimed to examine the mathematics prospective teachers' content language skills in some basic geometric concepts which are ray, angle, polygon,…
Understanding Thermal Equilibrium through Activities
ERIC Educational Resources Information Center
Pathare, Shirish; Huli, Saurabhee; Nachane, Madhura; Ladage, Savita; Pradhan, Hemachandra
2015-01-01
Thermal equilibrium is a basic concept in thermodynamics. In India, this concept is generally introduced at the first year of undergraduate education in physics and chemistry. In our earlier studies (Pathare and Pradhan 2011 "Proc. episteme-4 Int. Conf. to Review Research on Science Technology and Mathematics Education" pp 169-72) we…
Learning Multiplication Using Indonesian Traditional Game in Third Grade
ERIC Educational Resources Information Center
Prahmana, Rully Charitas Indra; Zulkardi; Hartono, Yusuf
2012-01-01
Several previous researches showed that students had difficulty in understanding the basic concept of multiplication. Students are more likely to be introduced by using formula without involving the concept itself. This underlies the researcher to design a learning trajectory of learning multiplication using Permainan Tradisional Tepuk Bergambar…
Entrepreneurship Education and Lower Socioeconomic Black Youth: An Empirical Investigation.
ERIC Educational Resources Information Center
Kourilsky, Marilyn L.; Esfandiari, Mahtash
1997-01-01
Tests the effectiveness of the New Youth Entrepreneur curriculum on lower socioeconomic black high-school students' knowledge of basic and advanced concepts in entrepreneurship. Results confirm that appropriate curricular innovation can significantly influence the acquisition of entrepreneurship concepts and skills by this group as well as…
American Interdependence Institute Teaching Materials.
ERIC Educational Resources Information Center
Kentucky Council on Economic Education.
The twin goals of this guide are to provide a greater understanding of basic economic concepts and an insight into Japanese culture. Economic concepts emphasized are: (1) scarcity; (2) choice; (3) production; (4) markets; (5) specialization and exchange; (6) sources of income; (7) free enterprise; and (8) marketing the product. Classroom…
The Nature of Employability Skills: Empirical Evidence from Singapore
ERIC Educational Resources Information Center
Sung, Johnny; Ng, Michael Chi Man; Loke, Fiona; Ramos, Catherine
2013-01-01
This paper concerns the changing nature of employability skills, moving from the original life skills or basic skills concepts to the increasingly work-oriented interpretation. The early concept of employability skills linked employability skills to job readiness and holding down employment. However, the work-oriented focus is increasingly linking…
Forest Inventory Mapmaker Users Guide
Patrick D. Miles
2001-01-01
The Forest Inventory Mapmaker Web application (http://www.ncrs.fs.fed.us/4801/fiadb/) provides users with the ability to easily generate tables and shaded maps. The goal of this manual is to present the basic concepts of the Web application to the user and to reinforce these concepts through the use of tutorials.
ERIC Educational Resources Information Center
Rzepa, Henry S.
2016-01-01
Three new examples are presented illustrating three-dimensional chemical information searches of the Cambridge structure database (CSD) from which basic core concepts in organic and inorganic chemistry emerge. These include connecting the regiochemistry of aromatic electrophilic substitution with the geometrical properties of hydrogen bonding…
Global energy regulation in the solar wind-magnetosphere-ionosphere system
NASA Technical Reports Server (NTRS)
Sato, T.
1985-01-01
Some basic concepts which are essential in the understanding of global energy regulation in the solar wind-magnetosphere-ionosphere system are introduced. The importance of line-tying concept is particularly emphasized in connection with the solar wind energy, energy release in the magnetosphere and energy dissipation in the ionosphere.
Welfare Triangles and Economic Policy Analysis.
ERIC Educational Resources Information Center
James, Stephen
1989-01-01
Shows how the concepts of consumer's surplus and producer's surplus can be related to basic welfare economics. Provides illustrations of the ways in which these concepts can be applied in introductory economics courses. Examines the social cost of monopoly, the tax burden, free trade, tariffs, and the English Channel Tunnel. (KO)
ERIC Educational Resources Information Center
Tabach, Michal; Friedlander, Alex
2009-01-01
One of the basic disagreements in mathematics education concerns the roles that rules and procedures, on the one hand, and concepts and principles, on the other hand, should play in students' learning of mathematics. The use of procedures and an understanding of concepts are considered to be two separate aspects of mathematical activity.…
The Keynesian Diagram: A Cross to Bear?
ERIC Educational Resources Information Center
Fleck, Juergen
In elementary economics courses students are often introduced to the basic concepts of macroeconomics through very simplified static models, and the concept of a macroeconomic equilibrium is generally explained with the help of an aggregate demand/aggregate supply (AD/AS) model and an income/expenditure model (via the Keynesian cross diagram).…
The Development of Preschoolers' Living Kinds Concept: A Longitudinal Study
ERIC Educational Resources Information Center
Margett-Jordan, Tessa; Falcon, Rachael G.; Witherington, David C.
2017-01-01
Given limitations in the integrative scope of past research, basic questions about the organization and development of preschoolers' living kinds concept remain open to debate. This study was designed to address past limitations through use of a longitudinal design, extensive stimulus set, and alternate indices of understanding. Thirty-five…
Teaching Health in a Natural History Museum.
ERIC Educational Resources Information Center
Newman, Ian M.
The opportunities offered by a natural history museum to enhance and expand classroom instruction in health are discussed. A basic constellation of typical natural history museum exhibit concepts and an array of health-related opportunities that are easily developed around these displays is outlined. The natural history concept provides an…
A Qualitative Approach to Electricity.
ERIC Educational Resources Information Center
Haertel, Hermann
In the teaching of physics, the study of electricity and magnetism typically follows the introduction of the basic concepts of mechanics. However, there are some new concepts associated with electromagnetic fields that seem at first to the student to be unrelated to, or even incompatible with, Newton's third law as learned in mechanics.…
Teaching Economics in the Mini-Economy.
ERIC Educational Resources Information Center
Indiana State Dept. of Education, Indianapolis.
This booklet produced by the State of Indiana introduces elementary teachers to economic concepts appropriate to the elementary curriculum and explains how to use mini-economy activities to teach these concepts. Chapter 1 describes how the mini-economy works, while chapter 2 introduces basic economic vocabulary and discusses market economy. Ideas…
CHANGING CONCEPTS OF PRODUCTIVE LIVING.
ERIC Educational Resources Information Center
BOYD, ROBERT D.
AT A CONFERENCE OF ADULT EDUCATORS DESIGNED TO BRING INTO FOCUS NEW PERSPECTIVES OF THE ROLES OF ADULT EDUCATION, PAPERS WERE PRESENTED ON THE CHANGING CONCEPTS OF PRODUCTIVE LIVING AND THE RELATIONSHIP BETWEEN CONCERN FOR PRODUCTIVE LIVING AND ADULT EDUCATION. AN OVERVIEW PROVIDED A WORKING ORIENTATION AND DESCRIBED THE BASIC FORCES AND PROBLEMS…
Multiple Solutions Approach (MSA): Conceptions and Practices of Primary School Teachers in Ghana
ERIC Educational Resources Information Center
Nabie, Michael Johnson; Raheem, Kolawole; Agbemaka, John Bijou; Sabtiwu, Rufai
2016-01-01
The study explored the curriculum guidelines and primary school teachers' conceptions and practices of the Multiple Solutions Approach (MSA) in teaching mathematics using basic qualitative research design. Informal conversation interviews (ICIs), observations, video and document analyses were used to collect data. Participants included a purposive…
Music Handbook for Primary Grades.
ERIC Educational Resources Information Center
Bowman, Doris; And Others
GRADES OR AGES: Primary grades (1, 2, and 3). SUBJECT MATTER: Music. ORGANIZATION AND PHYSICAL APPEARANCE: This guide contains a detailed outline of the basic music concepts for elementary grades with suggestions for activities which may develop understanding of the concepts. The pages of activities are color coded by grade level. There are three…
NASA to Launch Mars Rover in 2020 Artist Concept
2016-07-14
NASA's Mars 2020 Project will re-use the basic engineering of NASA's Mars Science Laboratory/Curiosity to send a different rover to Mars, with new objectives and instruments. This artist's concept depicts the top of the 2020 rover's mast. http://photojournal.jpl.nasa.gov/catalog/PIA20760
Building a Context of Experience: Communication Audits to Teach Communication Concepts.
ERIC Educational Resources Information Center
Husband, Robert L.; Helmer, James E.
The research audit is an effective means for providing undergraduate students with relevant organizational experience through which they can integrate theory and practice. A course was designed to teach students to apply basic concepts in the field of organizational communication to "real life" communication problems in organizations.…
ERIC Educational Resources Information Center
Ferrucci, Beverly J.; McDougall, Jennifer; Carter, Jack
2009-01-01
One challenge that middle school teachers commonly face is finding insightful, hands-on applications when teaching basic mathematical concepts. One concept that is a foundation of middle school mathematics is the notion of "linear functions." Although a variety of models can be used for linear equations, such as temperature conversions,…
Using Ontologies for Knowledge Management: An Information Systems Perspective.
ERIC Educational Resources Information Center
Jurisica, Igor; Mylopoulos, John; Yu, Eric
1999-01-01
Surveys some of the basic concepts that have been used in computer science for the representation of knowledge and summarizes some of their advantages and drawbacks. Relates these techniques to information sciences theory and practice. Concepts are classified in four broad ontological categories: static ontology, dynamic ontology, intentional…
An Economics Primer for Educators.
ERIC Educational Resources Information Center
Texas Education Agency, Austin. Div. of Curriculum Development.
This publication provides an introduction to basic concepts that form the core of economics education and gives a framework for curriculum planning and teaching. A brief introduction addresses the topic "Why study economics?" One major reason for promoting economic education may be to create a literate voting population. Fourteen concepts are then…
Reducing Abstraction When Learning Graph Theory
ERIC Educational Resources Information Center
Hazzan, Orit; Hadar, Irit
2005-01-01
This article presents research on students' understanding of basic concepts in Graph Theory. Students' understanding is analyzed through the lens of the theoretical framework of reducing abstraction (Hazzan, 1999). As it turns out, in spite of the relative simplicity of the concepts that are introduced in the introductory part of a traditional…
ERIC Educational Resources Information Center
Noad, Brian
1979-01-01
The Work Motivation Inventory, Minnesota Teacher Attitude Inventory, and Adjective Self Description Instrument were administered to 128 University of Houston student teachers. Results indicated that educational attitudes and self-concept, operating jointly, significantly contributed to the variance in Maslow's scales of basic, safety, and…
Teaching Embedded System Concepts for Technological Literacy
ERIC Educational Resources Information Center
Winzker, M.; Schwandt, A.
2011-01-01
A basic understanding of technology is recognized as important knowledge even for students not connected with engineering and computer science. This paper shows that embedded system concepts can be taught in a technological literacy course. An embedded system teaching block that has been used in an electronics module for non-engineers is…
On the management and processing of earth resources information
NASA Technical Reports Server (NTRS)
Skinner, C. W.; Gonzalez, R. C.
1973-01-01
The basic concepts of a recently completed large-scale earth resources information system plan are reported. Attention is focused throughout the paper on the information management and processing requirements. After the development of the principal system concepts, a model system for implementation at the state level is discussed.
For the last decade ecosystem services have received increasing focus, yet the natural and social scientists working on mainstreaming these concepts are still struggling with the basic issues. One of such issue is developing a framework that avoids double counting, provides guid...
ERIC Educational Resources Information Center
Malo, Eve; Bullard, Julie
This handbook was developed to assist educators and parents in fostering children's self-concept through developmentally appropriate kindergarten experiences. Guidelines for parental involvement, classroom volunteers, and families under stress are included. The handbook describes basic characteristics of children from ages 3-8 in terms of…
A Circular Evolution of Perspectives regarding Ethical Communication?
ERIC Educational Resources Information Center
Cox, E. Sam
The contemporary view of ethical communication has come full circle, returning to the approach of Aristotle. Almost every public speaking textbook includes discussion of the basic concepts of what Aristotle called ethos, pathos, and logos. Of particular significance is Aristotle's conception of ethos, as elaborated in his work, "The…
Solar Concepts: A Background Text.
ERIC Educational Resources Information Center
Gorham, Jonathan W.
This text is designed to provide teachers, students, and the general public with an overview of key solar energy concepts. Various energy terms are defined and explained. Basic thermodynamic laws are discussed. Alternative energy production is described in the context of the present energy situation. Described are the principal contemporary solar…
Satellite services system analysis study: Propellant transfer system
NASA Technical Reports Server (NTRS)
1982-01-01
General servicing requirements, a servicing mission concept and scenario, overall servicing needs, basic servicing equipment, and a general servicing mission configuration layout are addressed. Servicing needs, equipment concepts, system requirements equipment specifications, preliminary designs, and resource requirements for flight hardware for the propellant transfer system are also addressed.
Basic Substantive Law for Paralegals: Contracts, Torts, and Due Process.
ERIC Educational Resources Information Center
Marcin, Raymond B.
Part of the paralegal, or legal assistant, training materials prepared by the National Paralegal Institution under a Federal grant, the text comprises an overview of the basic legal concepts usually found in introductory law courses concerning contracts, torts, and the due process area of constitutional law. Part 1, Contracts, covers: definition,…
Toast, Anyone? Project Teaches Electricity Basics and Math
ERIC Educational Resources Information Center
Quagliana, David F.
2010-01-01
This article describes an electrical technology experiment that shows students how to determine the cost of using an electrical appliance. The experiment also provides good math practice and teaches basic electricity terms and concepts, such as volt, ampere, watt, kilowatt, and kilowatt-hour. This experiment could be expanded to calculate the cost…
The Art of Showing Art. Revised and Updated.
ERIC Educational Resources Information Center
Reeve, James K.
This book focuses attention on the art objects collections and how to display them. Designing the effective placement of objects is an easily learned art. Starting with the basics, the book takes the reader step by step through a systematic method, to solutions for display problems. The first chapter covers basic concepts of display including…
Management of Universal Basic Education Scheme (U.B.E.) for Qualitative Education in Nigeria
ERIC Educational Resources Information Center
Omotayo, Dare Michael; Ihebereme, Chioma; Maduewesi, Sir B. U.
2008-01-01
Since independence, Nigeria has been searching diligently for a viable educational system capable of enhancing the socio-economic and political values inherent in the country. This paper discusses concepts such as management, qualitative education and Universal Basic Education. In addition to the above, the paper also examines the National…
Orientation, Sketching, Mechanical Drawing, Drafting--Basic: 9253.01.
ERIC Educational Resources Information Center
Dade County Public Schools, Miami, FL.
The course introduces the student to the drafting trade, freehand sketching, and basic mechanical drawing. The course has no prerequisites and will guide the student into drafting concepts and serve as a foundation for further study in vocational drafting. Requiring a total of 45 class hours, eight hours are utilized in orientation, 15 hours are…
Similarity Theory and Dimensionless Numbers in Heat Transfer
ERIC Educational Resources Information Center
Marin, E.; Calderon, A.; Delgado-Vasallo, O.
2009-01-01
We present basic concepts underlying the so-called similarity theory that in our opinion should be explained in basic undergraduate general physics courses when dealing with heat transport problems, in particular with those involving natural or free convection. A simple example is described that can be useful in showing a criterion for neglecting…
Economics: An Analysis of Unintended Consequences. Volume 1: Introduction to Microeconomics.
ERIC Educational Resources Information Center
Schenk, Robert E.
This curriculum guide introduces high school students to the basic principles of microeconomics. Chapter 1 provides a basic definition of economics, while chapter 2 introduces a number of important economic concepts and ideas and examines reasons for unintended or unexpected consequences of decision-making. Chapter 3 considers how individual…
Basic Reference Tools for Nursing Research. A Workbook with Explanations and Examples.
ERIC Educational Resources Information Center
Smalley, Topsy N.
This workbook is designed to introduce nursing students to basic concepts and skills needed for searching the literatures of medicine, nursing, and allied health areas for materials relevant to specific information needs. The workbook introduces the following research tools: (1) the National Library of Medicine's MEDLINE searches, including a…
The Risks and Opportunities Associated with Weak Arithmatic Skills of Accounting Students
ERIC Educational Resources Information Center
Kerr, Stephen; Krull, George
2017-01-01
This paper explored the authors' concerns about students enrolled in their introductory accounting course. Anecdotal evidence suggested that students struggle with basic arithmetic concepts that underlie basic business transactions even though their math placement and ACT scores are high. A survey of 125 students in a first accounting course was…
Using Data Mining to Teach Applied Statistics and Correlation
ERIC Educational Resources Information Center
Hartnett, Jessica L.
2016-01-01
This article describes two class activities that introduce the concept of data mining and very basic data mining analyses. Assessment data suggest that students learned some of the conceptual basics of data mining, understood some of the ethical concerns related to the practice, and were able to perform correlations via the Statistical Package for…
Action Research of Computer-Assisted-Remediation of Basic Research Concepts.
ERIC Educational Resources Information Center
Packard, Abbot L.; And Others
This study investigated the possibility of creating a computer-assisted remediation program to assist students having difficulties in basic college research and statistics courses. A team approach involving instructors and students drove the research into and creation of the computer program. The effect of student use was reviewed by looking at…
Play Therapy: Basics and Beyond. Second Edition
ERIC Educational Resources Information Center
Kottman, Terry
2011-01-01
Written for use in play therapy and child counseling courses, this extraordinarily practical text provides a detailed examination of basic and advanced play therapy concepts and skills and guidance on when and how to use them. Kottman's multitheoretical approach and wealth of explicit techniques are also helpful for clinicians who want to gain…
Educational Strategies for Teaching Basic Family Dynamics to Non-Family Therapists.
ERIC Educational Resources Information Center
Merkel, William T.; Rudisill, John R.
1985-01-01
Presents six-part methodology for teaching basic concepts of family systems to non-family therapists and describes application of methodology to teach primary care physicians. Explains use of simulated encounters in which a physically symptomatic adolescent is interviewed alone, then with his mother, then with his whole family. (Author/NRB)
Basic Wiring. Third Edition. Teacher Edition [and] Student Edition.
ERIC Educational Resources Information Center
Kaltwasser, Stan; Flowers, Gary; Blasingame, Don; Batson, Larry; Ipock, Dan; Carroll, Charles; Friesen, Wade; Fleming, Glenn
This publication contains both a teacher edition and a student edition of materials for a foundation course in an electrical wiring program. The course introduces basic concepts and skills that are prerequisites to residential wiring and commercial and industrial wiring courses. The contents of the materials are tied to measurable and observable…
Aquatic Resources Education Curriculum.
ERIC Educational Resources Information Center
Pfeiffer, C. Boyd; Sosin, Mark
Fishing is one of the oldest and most popular outdoor activities. Like most activities, fishing requires basic knowledge and skill for success. The Aquatic Resources Education Curriculum is designed to assist beginning anglers in learning the basic concepts of how, when, and where to fish as well as what tackle to use. The manual is designed to be…
Energy and Economics. [Revised Edition.
ERIC Educational Resources Information Center
Walstad, William; Gleason, Joyce
This unit is designed to provide high school students with an introduction to topics of energy and economics. A basic premise of the unit is that energy issues and economics are interrelated. It is believed that the application of basic economic concepts to energy issues can provide students with the tools to improve their analysis of problems and…
Understanding the Financial Bottom Line: Career Decisions and Money.
ERIC Educational Resources Information Center
Martellino, Carl Anthony
Educating career counselors and other practitioners in the career development field on at least the basics of financial planning concepts will enable them to provide clients with a more comprehensive approach to career decisions. A client with an understanding of financial planning basics will be better prepared as an informed, engaged, and…
A Prototype HTML Training System for Graphic Communication Majors
ERIC Educational Resources Information Center
Runquist, Roger L.
2010-01-01
This design research demonstrates a prototype content management system capable of training graphic communication students in the creation of basic HTML web pages. The prototype serve as a method of helping students learn basic HTML structure and commands earlier in their academic careers. Exposure to the concepts of web page creation early in…
Ebner, Susanne; Fabritius, Cornelia; Ritschl, Paul; Oberhuber, Rupert; Günther, Julia; Kotsch, Katja
2014-10-01
A joint meeting organized by the European (ESOT) and The Transplantation (TTS) Societies for basic science research was organized in Paris, France, on November 7-9, 2013. Focused on new ideas and concepts in translational transplantation, the meeting served as a venue for state-of-the-art developments in basic transplantation immunology, such as the potential for tolerance induction through regulation of T-cell signaling. This meeting report summarizes important insights which were presented in Paris. It not only offers an overview of established aspects, such as the role of Tregs in transplantation, presented by Nobel laureate Rolf Zinkernagel, but also highlights novel facets in the field of transplantation, that is cell-therapy-based immunosuppression or composite tissue transplantation as presented by the emotional story given by Vasyly Rohovyy, who received two hand transplants. The ESOT/TTS joint meeting was an overall productive and enjoyable platform for basic science research in translational transplantation and fulfilled all expectations by giving a promising outlook for the future of research in the field of immunological transplantation research. © 2014 Steunstichting ESOT.
Leadership for the 1970’s. Field Grade Officer Leadership
1974-08-01
which are done or displayed most frequently. As in Figure 1, five lists are presented. This figure is basically a description of perceived leadership...Figure 3 are basically expectations or lists of desired behavior. On the left of the figure are listed the behaviors which superiors and subordinates...The basic idea of this concept is that if an individual feels that, for example, his superior should always be easy to understand but, in fact
1979-06-10
L. ......... ... ..D.. . C .. . . . .. . . 1 .. . .. ...... A COLIPhRATIVE STUDY OF Ti-M PRDVAIL-NC., .4D MORBIDITY OF SCHISTOSOMIASIS HA.SMATOBIUI...morbidity of 1 haematobium and b\\mansoni infection were compared in Egyptian children in matched age groups. The relationship of the prevalence to the...dating back to the ancient " gyptian period 1 . The ecological concept of schistosomiasis sugaests that in most endemic areas men and women of all
Ocular Hypertension and Chronic Open-Angle Glaucoma in USAF Pilots and Navigators
1974-12-01
nontreat- ment (close observation) of the preglaucoma category and treatment wit; epinephrine only of those classified glaucoma ha* been carried out now...concepts of glaucoma and glaucoma treatment versus the new "contemporary school" approach (differentiating ocular hypertension from glaucoma). This study...acute attack rather than the screening program. Onset ages for the secondary cases ranged from 28 to 53; 5 of these were secondary to uveitis , and
Group Additivity in Ligand Binding Affinity: An Alternative Approach to Ligand Efficiency.
Reynolds, Charles H; Reynolds, Ryan C
2017-12-26
Group additivity is a concept that has been successfully applied to a variety of thermochemical and kinetic properties. This includes drug discovery, where functional group additivity is often assumed in ligand binding. Ligand efficiency can be recast as a special case of group additivity where ΔG/HA is the group equivalent (HA is the number of non-hydrogen atoms in a ligand). Analysis of a large data set of protein-ligand binding affinities (K i ) for diverse targets shows that in general ligand binding is distinctly nonlinear. It is possible to create a group equivalent scheme for ligand binding, but only in the context of closely related proteins, at least with regard to size. This finding has broad implications for drug design from both experimental and computational points of view. It also offers a path forward for a more general scheme to assess the efficiency of ligand binding.
Motivating students' participation in a computer networks course by means of magic, drama and games.
Hilas, Constantinos S; Politis, Anastasios
2014-01-01
The recent economic crisis has forced many universities to cut down expenses by packing students into large lecture groups. The problem with large auditoria is that they discourage dialogue between students and faculty and they burden participation. Adding to this, students in computer science courses usually find the field to be full of theoretical and technical concepts. Lack of understanding leads them to lose interest and / or motivation. Classroom experience shows that the lecturer could employ alternative teaching methods, especially for early-year undergraduate students, in order to grasp their interest and introduce basic concepts. This paper describes some of the approaches that may be used to keep students interested and make them feel comfortable as they comprehend basic concepts in computer networks. The lecturing procedure was enriched with games, magic tricks and dramatic representations. This approach was used experimentally for two semesters and the results were more than encouraging.
Yusuf, Kareem; Badjah-Hadj-Ahmed, Ahmed Yacine; Aqel, Ahmad; Aouak, Taieb; ALOthman, Zeid Abdullah
2016-04-22
Thermodynamic characterization of butyl methacrylate-co-ethylene dimethacrylate neat monolith and zeolitic imidazolate framework-8 incorporated with butyl methacrylate-co-ethylene dimethacrylate composite monolith were studied using inverse gas chromatography at infinite dilution under 1MPa column pressure and various column temperatures. The free energy of adsorption (ΔGA), enthalpy of adsorption (ΔHA) and entropy of adsorption (ΔSA) were determined using a series of n-alkanes. The dispersive component of surface energy (γS(D)) was estimated by Dorris-Gray and Schultz et al. The composite monolith showed a more energetic surface than the neat monolith. The acidic, KA, and basic, KD, parameters for both materials were estimated using a group of polar probes. A basic character was concluded with more basic behavior for the neat monolith. Flory-Huggins parameter, χ, was taken as a measure of miscibility between the probes with the low molecular weight and the high molecular weight monolith. Inverse gas chromatography provides a better understanding of the role of incorporated zeolitic imidazolate framework (ZIF-8) into the polymer matrix in its monolithic form. Copyright © 2016 Elsevier B.V. All rights reserved.
Rashid, Mamun; Price, Nathaniel T; Gracia Pinilla, Miguel Ángel; O'Shea, Kevin E
2017-10-15
Effective removal of excess phosphate from water is critical to counteract eutrophication and restore water quality. In this study, low cost, environmentally friendly humic acid coated magnetite nanoparticles (HA-MNP) were synthesized and applied for the remediation of phosphate from aqueous media. The HA-MNPs, characterized by FTIR, TEM and HAADF-STEM showed the extensive coating of humic acid on the magnetite surface. The magnetic nanoparticles with diameters of 7-12 nm could be easily separated from the reaction mixture by using a simple hand held magnet. Adsorption studies demonstrate the fast and effective separation of phosphate with maximum adsorption capacity of 28.9 mg/g at pH 6.6. The adsorption behavior follows the Freundlich isotherm suggesting the formation of non-uniform multilayers of phosphate on the heterogeneous surface of HA-MNP. The adsorption kinetic fits the pseudo-second order model well with rate constants of 0.206 ± 0.003, 0.073 ± 0.002 and 0.061 ± 0.003 g mg -1 min -1 for phosphate (P) concentrations of 2, 5 and 10 mg/L respectively. The removal of phosphate was found higher at acidic and neutral pH compared to basic conditions. The nanoparticles exhibit good selectivity and adsorption efficiency for phosphate in presence of co-existing ions such as Cl - , SO 4 2- and NO 3 - with some inhibition effect by CO 3 2- . The effect of temperature on the adsorption reveals that the process is endothermic and spontaneous. HA-MNPs are promising, simple, environmentally friendly materials for the removal of phosphate from aqueous media. Copyright © 2017. Published by Elsevier Ltd.
Talore, Deribe G; Tesfamariam, Eyob H; Hassen, Abubeker; Du Toit, J C O; Klampp, Katja; Jean-Francois, Soussana
2016-04-01
Little is known about how basic soil properties respond to contrasting grazing intensities in the Karoo biome, South Africa. The aim of this study was to investigate impacts of long-term (>75 years) grazing at 1.18 heads ha(-1) (heavy; CGH), 0.78 heads ha(-1) (light; CGL), and exclosure on selected soil properties. Soil samples were collected to a depth of 60 cm from the long-term experimental site of Grootfontein Agricultural Development Institute, Eastern Cape. The samples were analyzed for C, N, bulk density and infiltration rate, among others. Generally, heavy and light grazing reduced soil N storage by 27.5% and 22.6%, respectively, compared with the exclosure. Animal exclusion improved water infiltration rate and C stocks significantly (P < 0.05), which was 0.128, 0.097, and 0.093 Mg ha(-1) yr(-1) for exclosure, CGL and CGH, respectively. Soil penetration resistance was higher for grazing treatments in the top 3-7 cm soil layer but for exclosure at the top 1 cm soil surface. Although livestock exclusion has the potential to improve C sequestration, a sufficient resting period for 1-2 years followed by three consecutive grazing years at light stocking rate would be ideal for sustainable livestock production in this arid region of South Africa. © 2015 Society of Chemical Industry.