10 CFR 16.15 - Procedures for internal salary offset.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Procedures for internal salary offset. 16.15 Section 16.15 Energy NUCLEAR REGULATORY COMMISSION SALARY OFFSET PROCEDURES FOR COLLECTING DEBTS OWED BY FEDERAL EMPLOYEES TO THE FEDERAL GOVERNMENT § 16.15 Procedures for internal salary offset. (a) Deductions to...

15 CFR 752.16 - Administrative actions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Administrative actions. 752.16 Section... COMPREHENSIVE LICENSE § 752.16 Administrative actions. (a)(1) If BIS is not satisfied that you or other parties... parties to such licenses are not adequate, BIS may, in addition to any enforcement action pursuant to part...

15 CFR 752.16 - Administrative actions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Administrative actions. 752.16 Section... COMPREHENSIVE LICENSE § 752.16 Administrative actions. (a)(1) If BIS is not satisfied that you or other parties... parties to such licenses are not adequate, BIS may, in addition to any enforcement action pursuant to part...

15 CFR 8b.16 - Discrimination prohibited.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Accessibility § 8b.16 Discrimination prohibited. No qualified handicapped individual shall, because a recipient... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Discrimination prohibited. 8b.16 Section 8b.16 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION...

15 CFR 8b.16 - Discrimination prohibited.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Accessibility § 8b.16 Discrimination prohibited. No qualified handicapped individual shall, because a recipient... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Discrimination prohibited. 8b.16 Section 8b.16 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION...

15 CFR 8b.16 - Discrimination prohibited.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Accessibility § 8b.16 Discrimination prohibited. No qualified handicapped individual shall, because a recipient... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Discrimination prohibited. 8b.16 Section 8b.16 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION...

15 CFR 8b.16 - Discrimination prohibited.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Accessibility § 8b.16 Discrimination prohibited. No qualified handicapped individual shall, because a recipient... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Discrimination prohibited. 8b.16 Section 8b.16 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-15 Valves...

15 CFR 719.16 - Extension of time.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Extension of time. 719.16 Section 719.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT...

15 CFR 719.16 - Extension of time.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Extension of time. 719.16 Section 719.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ENFORCEMENT...

15 CFR 8b.16 - Discrimination prohibited.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discrimination prohibited. 8b.16 Section 8b.16 Commerce and Foreign Trade Office of the Secretary of Commerce PROHIBITION OF DISCRIMINATION AGAINST THE HANDICAPPED IN FEDERALLY ASSISTED PROGRAMS OPERATED BY THE DEPARTMENT OF COMMERCE...

15 CFR 2008.16 - Security education program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Security education program. 2008.16... REPRESENTATIVE Safeguards § 2008.16 Security education program. (a) The Office of the Special Representative for... charged with the implementation of this security education program and shall issue detailed procedures for...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... EXPORT TRADE CERTIFICATES OF REVIEW § 325.16 Protecting confidentiality of information. (a) Any...

15 CFR 2008.16 - Security education program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Security education program. 2008.16 Section 2008.16 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

15 CFR 2008.16 - Security education program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Security education program. 2008.16 Section 2008.16 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

15 CFR 2008.16 - Security education program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Security education program. 2008.16 Section 2008.16 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

15 CFR 2008.16 - Security education program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Security education program. 2008.16 Section 2008.16 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

16 CFR 1700.15 - Poison prevention packaging standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Poison prevention packaging standards. 1700.15 Section 1700.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.15 Poison prevention packaging...

16 CFR 1700.15 - Poison prevention packaging standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Poison prevention packaging standards. 1700.15 Section 1700.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.15 Poison prevention packaging...

16 CFR 1700.15 - Poison prevention packaging standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Poison prevention packaging standards. 1700.15 Section 1700.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.15 Poison prevention packaging...

16 CFR 1700.15 - Poison prevention packaging standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Poison prevention packaging standards. 1700.15 Section 1700.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.15 Poison prevention packaging...

Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17.

PubMed Central

Ludwig, J; Blaschke, M; Sproat, B S

1998-01-01

In this paper, we show that an adenosine to inosine mutation at position 15.1 changes the substrate specificity of the hammerhead ribozyme from N16.2U16.1H17to N16.2C16.1H17(H represents A, C or U). This result extends the hammerhead cleavage triplet definition from N16.2U16.1H17to the more general N16.2Y16.1H17. Comparison of cleavage rates using I15.1ribozymes for NCH triplets and standard A15.1 ribozymes for NUH triplets under single turnover conditions shows similar or slightly enhanced levels of reactivity for the I15. 1-containing structures. The effect of I15.1 substitution was also tested in nuclease-resistant 2'- O -alkyl substituted derivatives (oligozymes), showing a similar level of activity for the NUH and NCH cleaving structures. The availability of NCH triplets that can be targeted without loss of efficiency increases the flexibility of ribozyme targeting strategies. This was demonstrated by an efficient cleavage of an HCV transcript at a previously inaccessible GCA site in codon 2. PMID:9580675

16 CFR 260.15 - Renewable energy claims.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Renewable energy claims. 260.15 Section 260... OF ENVIRONMENTAL MARKETING CLAIMS § 260.15 Renewable energy claims. (a) It is deceptive to misrepresent, directly or by implication, that a product or package is made with renewable energy or that a...

16 CFR 260.15 - Renewable energy claims.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Renewable energy claims. 260.15 Section 260... OF ENVIRONMENTAL MARKETING CLAIMS § 260.15 Renewable energy claims. (a) It is deceptive to misrepresent, directly or by implication, that a product or package is made with renewable energy or that a...

16 CFR 1000.15 - Office of Congressional Relations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Office of Congressional Relations. 1000.15 Section 1000.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION ORGANIZATION AND FUNCTIONS § 1000.15 Office of Congressional Relations. The Office of Congressional Relations is...

Cameras on the moon with Apollos 15 and 16.

NASA Technical Reports Server (NTRS)

Page, T.

1972-01-01

Description of the cameras used for photography and television by Apollo 15 and 16 missions, covering a hand-held Hasselblad camera for black and white panoramic views at locations visited by the astronauts, a special stereoscopic camera designed by astronomer Tom Gold, a 16-mm movie camera used on the Apollo 15 and 16 Rovers, and several TV cameras. Details are given on the far-UV camera/spectrograph of the Apollo 16 mission. An electronographic camera converts UV light to electrons which are ejected by a KBr layer at the focus of an f/1 Schmidt camera and darken photographic films much more efficiently than far-UV. The astronomical activity of the Apollo 16 astronauts on the moon, using this equipment, is discussed.

15 CFR 325.16 - Protecting confidentiality of information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Protecting confidentiality of information. 325.16 Section 325.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS...

16 CFR 1031.15 - Communication criteria.

Code of Federal Regulations, 2010 CFR

2010-01-01

... nature and a report of each oral communication of a substantive nature between a Commission official or... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Communication criteria. 1031.15 Section 1031... Communication criteria. (a) Commission officials and employees, who are not in the positions listed in § 1031.12...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

46 CFR 58.16-15 - Valves and safety relief devices.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Valves and safety relief devices. 58.16-15 Section 58.16-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND... and safety relief devices. (a) Each cylinder shall have a manually operated screw-down shutoff valve...

16 CFR 1500.15 - Labeling of fire extinguishers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Labeling of fire extinguishers. 1500.15 Section 1500.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT...)(1), the signal word “Danger” and the statement of hazard “Poisonous gases formed when used to...

15 CFR 16.10 - The Department of Commerce Mark.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

15 CFR 16.10 - The Department of Commerce Mark.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

15 CFR 16.10 - The Department of Commerce Mark.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

15 CFR 16.10 - The Department of Commerce Mark.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

15 CFR 16.10 - The Department of Commerce Mark.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false The Department of Commerce Mark. 16.10 Section 16.10 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.10 The Department of Commerce Mark. The Department of...

16 CFR § 1700.15 - Poison prevention packaging standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Poison prevention packaging standards. § 1700.15 Section § 1700.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS POISON PREVENTION PACKAGING § 1700.15 Poison prevention packaging...

Results of the Apollo 15 and 16 X-ray experiment

NASA Technical Reports Server (NTRS)

Adler, I.; Trombka, J. I.; Schmadebeck, R.; Lowman, P.; Blodget, H.; Yin, L.; Eller, E.; Podwysocki, M.; Weidner, J. R.; Bickel, A. L.

1973-01-01

Except for some minor modifications the Apollo 16 X-ray fluorescence experiment was similar to that flown aboard Apollo 15. The Apollo 16 provided data for a number of features not previously covered such as Mare Cognitum, Mare Nubium, Ptolemaeus, Descartes, Mendeleev, and other areas. Many data points were obtained by the X-ray experiments, so that comparisons could be drawn between Apollo 15 and 16 flights. The agreement was generally within about 10%. Al/Si concentration ratios ranged from 0.38% in Mare Cognitum to 0.67% in the Descartes area highlands. A comparison of the Apollo 16 data Al/Si values with optical albedo values along the ground tracks showed the same positive correlation as in the Apollo 15 flight. A reexamination of the detector and collimator geometries showed that the spatial resolution was better by almost a factor of two than the initial estimates.

16 CFR 1110.15 - Legal responsibility for certificate information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Legal responsibility for certificate information. 1110.15 Section 1110.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT... statute and its availability in timely fashion. ...

A de-novo interstitial microduplication involving 2p16.1-p15 and mirroring 2p16.1-p15 microdeletion syndrome: Clinical and molecular analysis.

PubMed

Mimouni-Bloch, Aviva; Yeshaya, Josepha; Kahana, Sarit; Maya, Idit; Basel-Vanagaite, Lina

2015-11-01

Microdeletions of various sizes in the 2p16.1-p15 chromosomal region have been grouped together under the 2p16.1-p15 microdeletion syndrome. Children with this syndrome generally share certain features including microcephaly, developmental delay, facial dysmorphism, urogenital and skeletal abnormalities. We present a child with a de-novo interstitial 1665 kb duplication of 2p16.1-p15. Clinical features of this child are distinct from those of children with the 2p16.1-p15 microdeletion syndrome, specifically the head circumference which is within the normal range and mild intellectual disability with absence of autistic behaviors. Microduplications many times bear milder clinical phenotypes in comparison with corresponding microdeletion syndromes. Indeed, as compared to the microdeletion syndrome patients, the 2p16.1-p15 microduplication seems to have a milder cognitive effect and no effect on other body systems. Limited information available in genetic databases about cases with overlapping duplications indicates that they all have abnormal developmental phenotypes. The involvement of genes in this location including BCL11A, USP34 and PEX13, affecting fundamental developmental processes both within and outside the nervous system may explain the clinical features of the individual described in this report. Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

15 CFR 30.16 - Export Administration Regulations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Export Administration Regulations. 30... OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Export Control and Licensing Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS...

46 CFR 193.15-16 - Lockout valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... EQUIPMENT Carbon Dioxide and Clean Agent Extinguishing Systems, Details § 193.15-16 Lockout valves. (a) A lockout valve must be provided on any carbon dioxide extinguishing system protecting a space over 6,000... complete isolation of the system from the protected space or spaces, making it impossible for carbon...

46 CFR 193.15-16 - Lockout valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... EQUIPMENT Carbon Dioxide and Clean Agent Extinguishing Systems, Details § 193.15-16 Lockout valves. (a) A lockout valve must be provided on any carbon dioxide extinguishing system protecting a space over 6,000... complete isolation of the system from the protected space or spaces, making it impossible for carbon...

45 CFR 16.15 - Failure to meet deadlines and other requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Failure to meet deadlines and other requirements. 16.15 Section 16.15 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION.... (a) Since one of the objectives of administrative dispute resolution is to provide a decision as fast...

15 CFR 16.6 - Establishment of fees and charges.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Establishment of fees and charges. 16... VOLUNTARY CONSUMER PRODUCT INFORMATION LABELING PROGRAM § 16.6 Establishment of fees and charges. (a) The... program, shall establish fees and charges for use of the Department of Commerce Label and Mark on each...

School Experiences of 15 and 16 Year-Olds. LSAY Briefing Number 16

ERIC Educational Resources Information Center

Underwood, Catherine; Rothman, Sheldon

2008-01-01

This "Briefing" provides a summary of students' experiences at school and their attitudes and perceptions of these experiences at ages 15 and 16. It is based on information obtained in both years from these young people who participated in Programme for International Student Assessment (PISA) in 2003 and are now part of the Longitudinal…

MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke.

PubMed

Yang, Xinxin; Tang, Xuelian; Sun, Ping; Shi, Yejie; Liu, Kai; Hassan, Sulaiman H; Stetler, R Anne; Chen, Jun; Yin, Ke-Jie

2017-07-01

Dysregulation of the miR-15a/16-1 cluster in plasma has been reported in patients with stroke as a potential biomarker for diagnostic and prognostic use. However, the essential role and therapeutic potential of the miR-15a/16-1 cluster in ischemic stroke are poorly understood. This study is aimed at investigating the regulatory role of the miR-15a/16-1 cluster in ischemic brain injury and insight mechanisms. Adult male miR-15a/16-1 knockout and wild-type mice, or adult male C57 BL/6J mice injected via tail vein with the miR-15a/16-1-specific inhibitor (antagomir, 30 pmol/g), were subjected to 1 hour of middle cerebral artery occlusion and 72 hours of reperfusion. The neurological scores, brain infarct volume, brain water content, and neurobehavioral tests were then evaluated and analyzed. To explore underlying signaling pathways associated with alteration of miR-15a/16-1 activity, major proinflammatory cytokines were measured by quantitative polymerase chain reaction or ELISA and antiapoptotic proteins were examined by Western blotting. Genetic deletion of the miR-15a/16-1 cluster or intravenous delivery of miR-15a/16-1 antagomir significantly reduced cerebral infarct size, decreased brain water content, and improved neurological outcomes in stroke mice. Inhibition of miR-15a/16-1 significantly decreased the expression of the proinflammatory cytokines interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule 1, tumor necrosis factor alpha, and increased Bcl-2 and Bcl-w levels in the ischemic brain regions. Our data indicate that pharmacological inhibition of the miR-15a/16-1 cluster reduces ischemic brain injury via both upregulation of antiapoptotic proteins and suppression of proinflammatory molecules. These results suggest that the miR-15a/16-1 cluster is a novel therapeutic target for ischemic stroke. © 2017 American Heart Association, Inc.

15 CFR 16.5 - Development of performance information labeling specifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Development of performance information labeling specifications. 16.5 Section 16.5 Commerce and Foreign Trade Office of the Secretary of Commerce... methods do not exist, they will be developed by the Department of Commerce in cooperation with interested...

15 CFR 16.5 - Development of performance information labeling specifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Development of performance information labeling specifications. 16.5 Section 16.5 Commerce and Foreign Trade Office of the Secretary of Commerce... methods do not exist, they will be developed by the Department of Commerce in cooperation with interested...

15. Historic American Buildings Survey Theodore Webb, Photographer, Mar. 16, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Historic American Buildings Survey Theodore Webb, Photographer, Mar. 16, 1934 DETAIL OF WINDOW (EAST RECEPTION ROOM) - Kentucky School for the Blind, 1867 Frankfort Avenue, Louisville, Jefferson County, KY

16 CFR 14.15 - In regard to comparative advertising.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false In regard to comparative advertising. 14.15... comparative advertising. (a) Introduction. The Commission's staff has conducted an investigation of industry trade associations and the advertising media regarding their comparative advertising policies. In the...

16 CFR 14.15 - In regard to comparative advertising.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false In regard to comparative advertising. 14.15... comparative advertising. (a) Introduction. The Commission's staff has conducted an investigation of industry trade associations and the advertising media regarding their comparative advertising policies. In the...

16 CFR 14.15 - In regard to comparative advertising.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false In regard to comparative advertising. 14.15... comparative advertising. (a) Introduction. The Commission's staff has conducted an investigation of industry trade associations and the advertising media regarding their comparative advertising policies. In the...

16 CFR 14.15 - In regard to comparative advertising.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false In regard to comparative advertising. 14.15... comparative advertising. (a) Introduction. The Commission's staff has conducted an investigation of industry trade associations and the advertising media regarding their comparative advertising policies. In the...

16 CFR 14.15 - In regard to comparative advertising.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false In regard to comparative advertising. 14.15... comparative advertising. (a) Introduction. The Commission's staff has conducted an investigation of industry trade associations and the advertising media regarding their comparative advertising policies. In the...

16. Historic American Buildings Survey Alex Bush, Photographer, October 15, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Historic American Buildings Survey Alex Bush, Photographer, October 15, 1935 CEILING DETAIL IN N. W. ROOM, 1ST FLOOR - University of Alabama, President's House, University Boulevard, Tuscaloosa, Tuscaloosa County, AL

16. "TEST STANDS NOS. 11, 13, & 15; STRUCTURAL STEEL; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. "TEST STANDS NOS. 1-1, 1-3, & 1-5; STRUCTURAL STEEL; ELEVATIONS AND SECTIONS." Specifications No. ENG 04353-50-10; Drawing No. 60-09-04; no sheet number within title block. D.O. SERIES 1109/35, Rev. A. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04-353 Eng. 177, Rev. A; Date: 29 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

16 CFR 300.15 - Labeling of containers or packaging of wool products.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Labeling of containers or packaging of wool products. 300.15 Section 300.15 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.15...

Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors

PubMed Central

Cittelly, Diana M.; Das, Partha M.; Salvo, Virgilio A.; Fonseca, Juan P.; Burow, Matthew E.; Jones, Frank E.

2010-01-01

Tamoxifen is the most commonly prescribed therapy for patients with estrogen receptor (ER)α-positive breast tumors. Tumor resistance to tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress human epidermal growth factor receptor 2 (HER2). Current preclinical models of HER2 overexpression fail to recapitulate the clinical spectrum of endocrine resistance associated with HER2/ER-positive tumors. Here, we show that ectopic expression of a clinically important oncogenic isoform of HER2, HER2Δ16, which is expressed in >30% of ER-positive breast tumors, promotes tamoxifen resistance and estrogen independence of MCF-7 xenografts. MCF-7/HER2Δ16 cells evade tamoxifen through upregulation of BCL-2, whereas mediated suppression of BCL-2 expression or treatment of MCF-7/HER2Δ16 cells with the BCL-2 family pharmacological inhibitor ABT-737 restores tamoxifen sensitivity. Tamoxifen-resistant MCF-7/HER2Δ16 cells upregulate BCL-2 protein levels in response to suppressed ERα signaling mediated by estrogen withdrawal, tamoxifen treatment or fulvestrant treatment. In addition, HER2Δ16 expression results in suppression of BCL-2-targeting microRNAs miR-15a and miR-16. Reintroduction of miR-15a/16 reduced tamoxifen-induced BCL-2 expression and sensitized MCF-7/HER2Δ16 to tamoxifen. Conversely, inhibition of miR-15a/16 in tamoxifen-sensitive cells activated BCL-2 expression and promoted tamoxifen resistance. Our results suggest that HER2Δ16 expression promotes endocrine-resistant HER2/ERα-positive breast tumors and in contrast to wild-type HER2, preclinical models of HER2Δ16 overexpression recapitulate multiple phenotypes of endocrine-resistant human breast tumors. The mechanism of HER2Δ16 therapeutic evasion, involving tamoxifen-induced upregulation of BCL-2 and suppression of miR-15a/16, provides a template for unique therapeutic interventions combining tamoxifen with modulation of microRNAs and/or ABT-737-mediated BCL-2

15. View looking northwest at the structure of Trestle 16. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. View looking northwest at the structure of Trestle 16. Sediment clean-out valve is visible at under left. - Lake Hodges Flume, Along San Dieguito River between Lake Hodges & San Dieguito Reservoir, Rancho Santa Fe, San Diego County, CA

16 CFR 500.15 - Units of count, more than one ply.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Units of count, more than one ply. 500.15... SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.15 Units of count, more than one ply. If the commodity is in distinct usable units made up of one or more components or ply, the statement of net...

16 CFR 500.15 - Units of count, more than one ply.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Units of count, more than one ply. 500.15... SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.15 Units of count, more than one ply. If the commodity is in distinct usable units made up of one or more components or ply, the statement of net...

16 CFR 500.15 - Units of count, more than one ply.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Units of count, more than one ply. 500.15... SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.15 Units of count, more than one ply. If the commodity is in distinct usable units made up of one or more components or ply, the statement of net...

16 CFR 500.15 - Units of count, more than one ply.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Units of count, more than one ply. 500.15... SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.15 Units of count, more than one ply. If the commodity is in distinct usable units made up of one or more components or ply, the statement of net...

16 CFR 500.15 - Units of count, more than one ply.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Units of count, more than one ply. 500.15... SECTION 4 OF THE FAIR PACKAGING AND LABELING ACT § 500.15 Units of count, more than one ply. If the commodity is in distinct usable units made up of one or more components or ply, the statement of net...

16 CFR 1203.15 - Positional stability test (roll-off resistance).

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Positional stability test (roll-off... SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.15 Positional stability test (roll-off resistance). (a) Test equipment. (1) Headforms. The test headforms shall comply with the...

16 CFR 1203.15 - Positional stability test (roll-off resistance).

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Positional stability test (roll-off... SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.15 Positional stability test (roll-off resistance). (a) Test equipment. (1) Headforms. The test headforms shall comply with the...

16 CFR 1203.15 - Positional stability test (roll-off resistance).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Positional stability test (roll-off... SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.15 Positional stability test (roll-off resistance). (a) Test equipment. (1) Headforms. The test headforms shall comply with the...

Carbon chemistry of the Apollo 15 and 16 deep drill cores

NASA Technical Reports Server (NTRS)

Wszolek, P. C.; Burlingame, A. L.

1973-01-01

The carbon chemistry of the Apollo 15 and 16 deep drill cores is a function of the surface exposure plus the chemical and mineralogical composition of the individual samples. The depth profiles of carbide and methane yields in the Apollo 15 core show a general decline with depth and correlate with the solar wind noble gas content, percentage agglutinates, track densities, and metallic iron. All horizons examined were exposed for a considerable time on the lunar surface. The Apollo 16 core samples show that chemical and mineralogical composition plays an important role in determining the nature of carbide-like material present in the fines. The higher aluminum and calcium contents and lower iron contents of highlands material result in carbide-like material yielding less CD4 and more C2D2 (deuteroacetylene) upon DF acid dissolution.

Antihalo effects on reaction cross sections for C14,15,16 isotopes

NASA Astrophysics Data System (ADS)

Matsumoto, Takuma; Yahiro, Masanobu

2014-10-01

We study antihalo effects on reaction cross sections σR for C14,15,16 scattering from a C12 target at 83 MeV/nucleon, using the g-matrix double-folding model. C15 is described by the 14C+n two-body model that reproduces the measured large s-wave spectroscopic factor, i.e., the shell inversion that the 1s1/2 orbital is lower than the 0d5/2 orbital in energy. C16 is described by the 14C+n+n three-body model with the phenomenological three-body force (3BF) that explains the measured small s-wave spectroscopic factor. The 3BF allows the single-particle energies of the 14C+n subsystem to depend on the position r of the second neutron from the center of mass of the subsystem. The 1s1/2 orbital is lower than the 0d5/2 orbital for large r, but the shell inversion is restored for small r. Antihalo effects due to the "partial shell inversion" make σR for C16 smaller than that for C15. We also investigate projectile breakup effects on the mass-number dependence of σR with the continuum-discretized coupled-channel method.

miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-β signaling pathway.

PubMed

Jin, Wei; Chen, Fangjie; Wang, Kefeng; Song, Yan; Fei, Xiang; Wu, Bin

2018-05-23

To determine whether and how miR15a/16 regulate TGF-β signaling pathways during the progression of prostate cancer. We used bioinformatics prediction, reporter gene assay, real-time PCR, Matrigel invasion assay and Western blot to dissect the molecular mechanism of how miR-15a/miR-16 may cause metastasis in prostate tumor. MiR-15a/16 targeted and inhibited the expression of endogenous Smad3 and ACVR2A proteins. The overexpression of miR15a/16 down-regulated p-smad3 expression, affected the expression of both MMP2 and E-cadherin, and down-regulated the expression of the EMT-mediated factors Snail and Twist in LNCaP prostate cancer cells. The overexpression of miR15a/16 decreased the invasion of LNCaP cells. MiR-15a/miR-16 cluster could reverse the invasion of activin A-mediated prostate cancer cells. After the inhibition of the activin/smad signaling pathway, the inhibitory effect of invasion in prostate cancer cells by miR-15a/miR-16 cluster disappeared. Our data indicated that miR15a/16 inhibited the components of TGF-β signaling pathways in LNCaP cell line, which might relate to the progression and metastasis of prostate cancer. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Papers from the Community College Governance Conference, February 15-16, 1974.

ERIC Educational Resources Information Center

Washington State Board for Community Coll. Education, Olympia.

Papers presented at a conference on community college governance, held in Seattle, Washington on February 15-16, 1974, are provided. The papers are: "Governance for the Two-Year College" by Richard C. Richardson, Jr.: "The Faculty Stake in Governance" by Richard J. Frankie; "The Student Stake in Governance" by Alan R. Shark; "The Public Interest…

78 FR 51206 - Notice of October 15-16, 2013, Meeting of the National Park System Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

....YM0000] Notice of October 15-16, 2013, Meeting of the National Park System Advisory Board AGENCY... Federal Regulations, that the National Park System Advisory Board will meet October 15-16, 2013, in... Landmarks Program and the National Natural Landmarks Program. The Board also may consider recommendations in...

16 CFR 1117.6 - Relation to section 15(b) of the CPSA.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Relation to section 15(b) of the CPSA. 1117.6 Section 1117.6 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS REPORTING OF CHOKING INCIDENTS INVOLVING MARBLES, SMALL BALLS, LATEX BALLOONS AND OTHER SMALL...

15 CFR 19.16 - When will Commerce entities refer Commerce debts to the Department of Justice?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false When will Commerce entities refer Commerce debts to the Department of Justice? 19.16 Section 19.16 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.16 When will...

15 CFR 19.16 - When will Commerce entities refer Commerce debts to the Department of Justice?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false When will Commerce entities refer Commerce debts to the Department of Justice? 19.16 Section 19.16 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.16 When will...

15 CFR 19.16 - When will Commerce entities refer Commerce debts to the Department of Justice?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false When will Commerce entities refer Commerce debts to the Department of Justice? 19.16 Section 19.16 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.16 When will...

15 CFR 19.16 - When will Commerce entities refer Commerce debts to the Department of Justice?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false When will Commerce entities refer Commerce debts to the Department of Justice? 19.16 Section 19.16 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.16 When will...

15 CFR 19.16 - When will Commerce entities refer Commerce debts to the Department of Justice?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false When will Commerce entities refer Commerce debts to the Department of Justice? 19.16 Section 19.16 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.16 When will...

17 CFR 240.15d-16 - Reports of foreign private issuers on Form 6-K [17 CFR 249.306].

Code of Federal Regulations, 2012 CFR

2012-04-01

... issuers on Form 6-K [17 CFR 249.306]. 240.15d-16 Section 240.15d-16 Commodity and Securities Exchanges... foreign private issuers on Form 6-K [17 CFR 249.306]. (a) Every foreign private issuer which is subject to Rule 15d-1 [17 CFR 240.15d-1] shall make reports on Form 6-K, except that this rule shall not apply to...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for projects...

Aβ1-15/16 as a marker for γ-secretase inhibition in Alzheimer’s disease

PubMed Central

Portelius, Erik; Zetterberg, Henrik; Dean, Robert A.; Marcil, Alexandre; Bourgeois, Philippe; Nutu, Magdalena; Andreasson, Ulf; Siemers, Eric; Mawuenyega, Kwasi G.; Sigurdson, Wendy C.; May, Patrick C.; Paul, Steven M.; Holtzman, David M.; Blennow, Kaj; Bateman, Randall J.

2013-01-01

Amyloid-β (Aβ) producing enzymes are key targets for disease-modifying Alzheimer’s disease (AD) therapies since Aβ trafficking is at the core of AD pathogenesis. Development of such drugs might benefit from the identification of markers indicating in vivo drug effects in the central nervous system. We have previously shown that Aβ1-15 is produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP). Here, we test the hypothesis that this pathway is more engaged upon γ-secretase inhibition in humans and cerebrospinal fluid (CSF) levels of Aβ1-15/16 represent a biomarker for this effect. Twenty healthy men were treated with placebo (n=5) or the γ-secretase inhibitor semagacestat (100 mg [n=5], 140 mg [n=5], or 280 mg [n=5]). CSF samples were collected hourly over 36 hours and 10 time points were analyzed by immunoassay for Aβ1-15/16, Aβx-38, Aβx-40, Aβx-42, sAβPPα and sAβPPβ. The CSF concentration of Aβ1-15/16 showed a dose-dependent response over 36 hours. In the 280 mg treatment group, a transient increase was seen with a maximum of 180% relative to baseline at 9 hours post administration of semagacestat. The concentrations of Aβx-38, Aβx-40 and Aβx-42 decreased the first 9 hours followed by increased concentrations after 36 hours relative to baseline. No significant changes were detected for CSF sAβPPα and sAβPPβ.Our data shows that CSF levels of Aβ1-15/16 increase during treatment with semagacestat supporting its feasibility as a pharmacodynamic biomarker for drug candidates aimed at inhibiting γ-secretase-mediated AβPP-processing. PMID:22531418

Social Emotional Skills and Prosocial Behaviour among 15-16-Year-Old Adolescents

ERIC Educational Resources Information Center

Akelaitis, Arturas V.; Lisinskiene, Ausra R.

2018-01-01

The purpose of this study was to determine and compare social emotional skills and prosocial behaviour among 15-16-year-old adolescent athletes and non-athletes. The measures of social emotional skills and prosocial behaviour were evaluated using Schutte Self-Report Inventory, Self-control scale, Social Skills Rating System (Student form),…

Ethnic group and alcohol consumption: the case of 15-16-year-olds in Leicestershire.

PubMed

Denscombe, M

1995-03-01

In recent years a number of research projects have reported on the level of alcohol use by young people. The research to date, however, has tended to overlook the ethnic origins of the young people as a factor associated with the level of alcohol use. Against this background, this paper reports findings on the use of alcohol by 15-16-year-olds in Leicestershire with specific reference to ethnic group. A survey of over 1000 young people revealed significant differences between ethnic groups in terms of their attitudes to alcohol consumption and the frequency of alcohol consumption. As expected, South Asians tended to hold less favourable attitudes to drinking alcohol than their White counterparts and reported a far lower frequency of alcohol consumption. The extent of the divergence between the two ethnic groups is detailed, revealing a stark contrast between the groups at age 15-16 years. Attitudes to alcohol consumption and reported frequency of alcohol consumption were also analysed in relation to the religion of the respondents. This analysis was undertaken to see if there were differences within the broader ethnic groups which would be disguised by aggregating the results under the headings of 'South Asian' and 'White'. Within the South Asian group, some differences in attitudes to the consumption of alcohol were found between Hindus, Sikhs and Muslims, with the Muslims exhibiting particular sensitivity to their religion's proscription of drinking alcohol. Despite this, the reported level of drinking by the Hindus and Sikhs was not much greater than that of the Muslims. The three groups tended to have a similar frequency of alcohol consumption which was markedly lower than that reported by the White 15-16-year-olds. The findings from the DART research have certain substantive and certain methodological implications in relation to epidemiological studies of alcohol consumption. Substantively, the findings reinforce the need to include ethnic group as a key

Mn-53 in the Apollo 15 and 16 drill stems - Evidence for surface mixing

NASA Technical Reports Server (NTRS)

Nishiizumi, K.; Imamura, M.; Honda, M.; Russ, G. P., III; Kohl, C. P.; Arnold, J. R.

1976-01-01

The activity of cosmic ray produced Mn-53 has been measured in a series of samples from the upper 10 cm of the Apollo 15 and 16 drill stems. The activity profiles for both cores indicate disturbance to depths of about 3 g/sq cm within the last 6 m.y. In at least one case (Apollo 16) the soil has been gardened to at least 14 g/sq cm within the last 10 m.y., and material from the upper less than 2 g/sq cm has been buried to 14 g/sq cm by this gardening. The results for the Apollo 15 core are compatible with a wide variety of possible histories including loss or gain of material.

Updating the Geologic Maps of the Apollo 15, 16, and 17 Landing Sites

NASA Astrophysics Data System (ADS)

Garry, W. B.; Mest, S. C.; Yingst, R. A.; Ostrach, L. R.; Petro, N. E.; Cohen, B. A.

2018-06-01

Our team is funded through NASA's Planetary Data Archiving, Restoration, and Tools (PDART) program to produce two new USGS Special Investigation Maps (SIM) for the Apollo 15, 16, and 17 missions: a regional map (1:200K) and a landing-site map (1:24K).

Advancing Student Achievement through Labor-Management Collaboration (Denver, Colorado, February 15-16, 2011)

ERIC Educational Resources Information Center

US Department of Education, 2011

2011-01-01

This paper presents the highlights of a conference entitled "Advancing Student Achievement through Labor-Management Collaboration" held in Denver, Colorado last February 15-16, 2011. This first-of-its-kind conference on labor-management collaboration is a historic effort to transform the relationships among local superintendents, school…

Abstracts, 21st Annual Meeting Society of Engineering Science, Inc., October 15, 16 and 17, 1984.

DTIC Science & Technology

1984-01-01

ANALYSIS OF ADHESIVE JOINTS IN FIBER REINFORCED COMPOSITES by C. Burger*, D. Mallik **, A. Voloshin* and S. Mahadevan* *Department of Engineering Science...N. 33 (15A,44)Halkus, D.S. 301 ( 16 PM6) Olaosebikan, L. 89,95 (15PM2) Mallik , D. 356 (17AH2) Olhoff, N. 456,459 (l7PM4)Malone, J.B. 128 (15PM5

16 CFR 1101.23 - Providing less than 15 days notice before disclosing information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Providing less than 15 days notice before disclosing information. 1101.23 Section 1101.23 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Procedure for Providing Notice...

16 CFR 1101.23 - Providing less than 15 days notice before disclosing information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Providing less than 15 days notice before disclosing information. 1101.23 Section 1101.23 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Procedure for Providing Notice...

16 CFR 1101.23 - Providing less than 15 days notice before disclosing information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Providing less than 15 days notice before disclosing information. 1101.23 Section 1101.23 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Procedure for Providing Notice...

Mid-Atlantic multichannel seismic-reflection profiles 14, 15, 16, and 17

USGS Publications Warehouse

Schlee, John Stevens

1980-01-01

The U. S. Geological Survey (USGS) is making available four multi­channel profiles collected by Teledyne Exploration in 1977 by means of a 48-channel streamer (3600 m long) and four airguns (2160 in). Profiles 15 and 16 were processed by.Teledyne Exploration and profiles 14 and 17 were processed on the Phoenix "I"* computer·by the USGS. The processing included standard demultiplexing, deconvolution before and aftfer stack, Common Depth Point (CDP) gathers, velocity analyses every 3 km, move-out correction, stacking, time-variant, filtering, and time-variant scaling.The released lines are over the outer edge of the Continental Shelf in the northern part of the Baltimore Canyon trough (Line 14: 140 km long and Line 15: 157 km long), over the Long Island platform. (Line 16: 313 km long), and over the Carolina platform (Line 17: 186 km long). These profiles were collected as a part of a regional grid over offshore Atlantic sedimentary basins in a continuing program to assess the resource potential by means of nonproprietary data.These profiles, plus the velocity scans and shotpoint maps, may be viewed at U. S. Geological Survey, Quissett Campus, Woods Hole, MA. 02543, and U. S. Geological Survey, Bldg. 25, Denver Federal Center, Denver, CO. Copies of maps, scans, and profiles can be purchased only from the National Geophysical Solar-Terrestrial Data Center, Environmental Data Service (NOM), Code D 621, Boulder, CO 80302.

Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications.

PubMed

Geraldes, Catarina; Gonçalves, Ana Cristina; Cortesão, Emília; Pereira, Marta Isabel; Roque, Adriana; Paiva, Artur; Ribeiro, Letícia; Nascimento-Costa, José Manuel; Sarmento-Ribeiro, Ana Bela

2016-12-01

Aberrant DNA methylation is considered a crucial mechanism in the pathogenesis of monoclonal gammopathies. We aimed to investigate the contribution of hypermethylation of 4 tumor suppressor genes to the multistep process of myelomagenesis. The methylation status of p15, p16, p53, and DAPK genes was evaluated in bone marrow samples from 94 patients at diagnosis: monoclonal gammopathy of uncertain significance (MGUS) (n = 48), smoldering multiple myeloma (SMM) (n = 8) and symptomatic multiple myeloma (MM) (n = 38), and from 8 healthy controls by methylation-specific polymerase chain reaction analysis. Overall, 63% of patients with MM and 39% of patients with MGUS presented at least 1 hypermethylated gene (P < .05). No aberrant methylation was detected in normal bone marrow. The frequency of methylation for individual genes in patients with MGUS, SMM, and MM was p15, 15%, 50%, 21%; p16, 15%, 13%, 32%; p53, 2%, 12,5%, 5%, and DAPK, 19%, 25%, 39%, respectively (P < .05). No correlation was found between aberrant methylation and immunophenotypic markers, cytogenetic features, progression-free survival, and overall survival in patients with MM. The current study supports a relevant role for p15, p16, and DAPK hypermethylation in the genesis of the plasma cell neoplasm. DAPK hypermethylation also might be an important step in the progression from MGUS to MM. Copyright © 2016 Elsevier Inc. All rights reserved.

Polydrug Use among 15- to 16-Year Olds: Similarities and Differences in Europe

ERIC Educational Resources Information Center

Olszewski, Deborah; Matias, Joao; Monshouwer, Karin; Kokkevi, Anna

2010-01-01

Aims: We describe types of polydrug use among school students across Europe and explore differences between high, medium and low drug prevalence countries. Method: Analysis is based on survey data from over 70,000 15- to 16-year-old school students in 22 European countries. Polydrug use (defined as the use of two or more listed substances during…

The Mediator Complex Subunits MED14, MED15, and MED16 Are Involved in Defense Signaling Crosstalk in Arabidopsis.

PubMed

Wang, Chenggang; Du, Xuezhu; Mou, Zhonglin

2016-01-01

Mediator is a highly conserved protein complex that functions as a transcriptional coactivator in RNA polymerase II (RNAPII)-mediated transcription. The Arabidopsis Mediator complex has recently been implicated in plant immune responses. Here, we compared salicylic acid (SA)-, methyl jasmonate (MeJA)-, and the ethylene (ET) precursor 1-aminocyclopropane-1-carboxylic acid (ACC)-induced defense and/or wound-responsive gene expression in 14 Arabidopsis Mediator subunit mutants. Our results show that MED14, MED15, and MED16 are required for SA-activated expression of the defense marker gene PATHOEGNESIS-RELATED GENE1 , MED25 is required for MeJA-induced expression of the wound-responsive marker gene VEGATATIVE STORAGE PROTEIN1 ( VSP1 ), MED8, MED14, MED15, MED16, MED18, MED20a, MED25, MED31, and MED33A/B (MED33a and MED33B) are required for MeJA-induced expression of the defense maker gene PLANT DEFENSIN1.2 ( PDF1.2 ), and MED8, MED14, MED15, MED16, MED25, and MED33A/B are also required for ACC-triggered expression of PDF1.2 . Furthermore, we investigated the involvement of MED14, MED15, and MED16 in plant defense signaling crosstalk and found that MED14, MED15, and MED16 are required for SA- and ET-mediated suppression of MeJA-induced VSP1 expression. This result suggests that MED14, MED15, and MED16 not only relay defense signaling from the SA and JA/ET defense pathways to the RNAPII transcription machinery, but also fine-tune defense signaling crosstalk. Finally, we show that MED33A/B contributes to the necrotrophic fungal pathogen Botrytis cinerea- induced expression of the defense genes PDF1.2, HEVEIN-LIKE , and BASIC CHITINASE and is required for full-scale basal resistance to B. cinerea , demonstrating a positive role for MED33 in plant immunity against necrotrophic fungal pathogens.

Quantitative analysis of terrain units mapped in the northern quarter of Venus from Venera 15/16 data

NASA Technical Reports Server (NTRS)

Schaber, G. G.

1991-01-01

The contacts between 34 geological/geomorphic terrain units in the northern quarter of Venus mapped from Venera 15/16 data were digitized and converted to a Sinusoidal Equal-Area projection. The result was then registered with a merged Pioneer Venus/Venera 15/16 altimetric database, root mean square (rms) slope values, and radar reflectivity values derived from Pioneer Venus. The resulting information includes comparisons among individual terrain units and terrain groups to which they are assigned in regard to percentage of map area covered, elevation, rms slopes, distribution of suspected craters greater than 10 km in diameter.

16 CFR 23.15 - Misuse of the term “properly cut,” etc.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Misuse of the term âproperly cut,â etc. 23... FOR THE JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.15 Misuse of the term “properly cut,” etc. It is unfair or deceptive to use the terms “properly cut,” “proper cut,” “modern cut,” or any...

16 CFR 23.15 - Misuse of the term “properly cut,” etc.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Misuse of the term âproperly cut,â etc. 23... FOR THE JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.15 Misuse of the term “properly cut,” etc. It is unfair or deceptive to use the terms “properly cut,” “proper cut,” “modern cut,” or any...

Therapeutic Implications of Activation of the Host Gene (Dleu2) Promoter for miR-15a/16-1 in Chronic Lymphocytic Leukemia (CLL)

PubMed Central

Kasar, S; Underbayev, C; Yuan, Y; Hanlon, M; Aly, S; Chang, V; Batish, M; Gavrilova, T; Badiane, F; Degheidy, H; Marti, G; Raveche, E

2014-01-01

Genetic lesions and other regulatory events lead to silencing of the 13q14 locus in a majority of chronic lymphocytic leukemia (CLL) patients. This locus encodes a pair of critical pro-apoptotic microRNAs, miR-15a/16-1. Decreased levels of miR-15a/16-1 are critical for the increased survival exhibited by CLL cells. Similarly, in a de novo murine model of CLL, the NZB strain, germline-encoded regulation of the syntenic region resulted in decreased miR-15a/16-1. In this paper we have identified additional molecular mechanisms regulating miR-15a/16-1 levels and shown that the transcription factor BSAP (B cell Specific Activator Protein) directly interacts with Dleu2, the host gene containing the mir-15a/16-1 loci and via negative regulation of the Dleu2 promoter results in repression of mir-15a/16 expression. CLL patient B cell expression levels of BSAP were increased compared to control sources of B cells. With the use of siRNA mediated repression, the levels of BSAP were decreased in vitro in the NZB derived malignant B1 cell line, LNC, and in ex vivo CLL patient PBMC. BSAP knockdown led to an increase in the expression of miR-15a/16-1 and an increase in apoptosis and a cell cycle arrest in both the cell line and patient PBMC. Moreover, using Dleu2 promoter analysis by chromatin immunoprecipitation (ChIP) assay we have shown that BSAP directly interacts with the Dleu2 promoter. Derepression of the Dleu2 promoter via inhibition of histone deacetylation combined with BSAP knockdown increased miR-15a/16 expression and increased malignant B cell death. In summary, therapy targeting enhanced host gene Dleu2 transcription may augment CLL therapy. PMID:23995789

49 CFR 172.411 - EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels..., 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label. (a) Except for size and color....5 and EXPLOSIVE 1.6 labels must be as follows: EXPLOSIVE 1.4: EC02MR91.016 EXPLOSIVE 1.5: EC02MR91...

16 CFR § 1101.23 - Providing less than 15 days notice before disclosing information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Providing less than 15 days notice before disclosing information. § 1101.23 Section § 1101.23 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Procedure for Providing...

Constraining the S factor of {sup 15}N(p,{gamma}){sup 16}O at astrophysical energies

DOE Office of Scientific and Technical Information (OSTI.GOV)

LeBlanc, P. J.; Goerres, J.; Beard, M.

2010-11-15

The {sup 15}N(p,{gamma}){sup 16}O reaction represents a breakout reaction linking the first and second cycles of the CNO cycles redistributing the carbon and nitrogen abundances into the oxygen range. The reaction is dominated by two broad resonances, at E{sub p}=338 and 1028 keV, and a direct capture contribution to the ground state of {sup 16}O. Interference effects between these contributions both in the low-energy region (E{sub p}<338 keV) and between the two resonances (33815}N(p,{gamma}){sup 16}O reaction has been remeasured coveringmore » the energy range from E{sub p}=1800 keV down to 130 keV. The results have been analyzed in the framework of a multilevel R-matrix theory and an S(0) value of 39.6 keV b has been found.« less

The New Outlook for Science. Science and Belief: from Copernicus to Darwin, Block VI, Units 15-16.

ERIC Educational Resources Information Center

Open Univ., Walton, Bletchley, Bucks (England).

This text contains units 15-16 in the Open University course, Science and Belief: from Copernicus to Darwin. It is an inter-faculty second level course in the history of science. Unit 15 is concerned with Nature and History and includes uniformitarianism, human history, evolutionism, and Darwinism. Unit objectives, readings, and questions with the…

16 CFR 1210.15 - Specifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.15 Specifications. (a) Requirement... described in a written product specification. (Section 1210.4(c) requires that six surrogate lighters be...

Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis

PubMed Central

Bagheri, Hani; Badduke, Chansonette; Qiao, Ying; Colnaghi, Rita; Abramowicz, Iga; Alcantara, Diana; Dunham, Christopher; Wen, Jiadi; Wildin, Robert S.; Nowaczyk, Malgorzata J.M.; Eichmeyer, Jennifer; Lehman, Anna; Maranda, Bruno; Martell, Sally; Shan, Xianghong; Lewis, Suzanne M.E.; O’Driscoll, Mark; Gregory-Evans, Cheryl Y.

2016-01-01

The 2p15p16.1 microdeletion syndrome has a core phenotype consisting of intellectual disability, microcephaly, hypotonia, delayed growth, common craniofacial features, and digital anomalies. So far, more than 20 cases of 2p15p16.1 microdeletion syndrome have been reported in the literature; however, the size of the deletions and their breakpoints vary, making it difficult to identify the candidate genes. Recent reports pointed to 4 genes (XPO1, USP34, BCL11A, and REL) that were included, alone or in combination, in the smallest deletions causing the syndrome. Here, we describe 8 new patients with the 2p15p16.1 deletion and review all published cases to date. We demonstrate functional deficits for the above 4 candidate genes using patients’ lymphoblast cell lines (LCLs) and knockdown of their orthologs in zebrafish. All genes were dosage sensitive on the basis of reduced protein expression in LCLs. In addition, deletion of XPO1, a nuclear exporter, cosegregated with nuclear accumulation of one of its cargo molecules (rpS5) in patients’ LCLs. Other pathways associated with these genes (e.g., NF-κB and Wnt signaling as well as the DNA damage response) were not impaired in patients’ LCLs. Knockdown of xpo1a, rel, bcl11aa, and bcl11ab resulted in abnormal zebrafish embryonic development including microcephaly, dysmorphic body, hindered growth, and small fins as well as structural brain abnormalities. Our multifaceted analysis strongly implicates XPO1, REL, and BCL11A as candidate genes for 2p15p16.1 microdeletion syndrome. PMID:27699255

Familial interstitial deletion of the short arm of chromosome 4 (p15.33-p16.3) characterized by molecular cytogenetic analysis.

PubMed

Basinko, Audrey; Douet-Guilbert, Nathalie; Parent, Philippe; Blondin, Gilles; Mingam, M; Monot, Françoise; Morel, Frédéric; Le Bris, Marie-Josée; De Braekeleer, Marc

2008-04-01

This 15-month boy was expressed at the cytogenetic laboratory because of psychomotor development delay. He was tall and had plagiocephaly, micrognathia, high nasal bridge, anteverted nostrils and pectus excavatum. A 46,XY,del(4)(p16.1p16.3) karyotype was found using high-resolution R-banding technique. FISH studies using the LSI Wolf-Hirschhorn dual color 4p16.3 and the TelVysion 4p probes showed no deletion. Using BACs, the distal breakpoint was located in 4p16.3, between RP11-165K4 and RP11-717M10 and the proximal breakpoint in 4p15.33, between RP11-74M11 and RP11-1J7; therefore, approximately 7.96 Mb of the short arm were deleted. The maternal karyotype showed the same deletion, but in a mosaic status. Two distinct phenotypes have been recognized on the basis of the chromosomal bands involved in 4p deletion: the Wolf-Hirschhorn syndrome (WHS) and a proximal 4p deletion syndrome (4p15.2-p15.32). Our observation confirms that the basic WHS phenotype maps distally to this region. Copyright 2008 Wiley-Liss, Inc.

21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119 7...

21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119 7...

21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119 7...

21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119 7...

21 CFR 73.3119 - 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false 7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone. 73.3119 Section 73.3119 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3119 7...

miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lan, Fengming; Radiation Oncology Department, Tianjin Hospital, Tianjin; Yue, Xiao

2015-01-01

Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealedmore » in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.« less

PERSISTENT CURRENT EFFECT IN 15-16 T NB3SN ACCELERATOR DIPOLES AND ITS CORRECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kashikhin, V. V.; Zlobin, A. V.

2016-11-08

Nb3Sn magnets with operating fields of 15-16 T are considered for the LHC Energy Doubler and a future Very High Energy pp Collider. Due to large coil volume, high critical current density and large superconducting (SC) filament size the persistent current effect is very large in Nb3Sn dipoles al low fields. This paper presents the results of analysis of the persistent current effect in the 15 T Nb3Sn dipole demonstrator being developed at FNAL, and describes different possibilities of its correction including passive SC wires, iron shims and coil geometry.

An Investigation into the Representation of Geological Maps by 15-16 Year-Old Turkish Students

ERIC Educational Resources Information Center

Dal, Burckin

2010-01-01

This paper explores secondary school students' representations of a geological map. Ninety-two high school students (ninth graders--15- to 16-years-old) participated in the survey in Turkey. The findings indicate that students have only a vague idea of how a geological map is constructed, and how the map is affected by the topography. The…

47 CFR 15.252 - Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz. 15.252 Section 15.252 Telecommunication FEDERAL..., Additional Provisions § 15.252 Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz...

47 CFR 15.252 - Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz. 15.252 Section 15.252 Telecommunication FEDERAL..., Additional Provisions § 15.252 Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz...

47 CFR 15.252 - Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz. 15.252 Section 15.252 Telecommunication FEDERAL..., Additional Provisions § 15.252 Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz...

47 CFR 15.252 - Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz and 23.12-29.0 GHz. 15.252 Section 15.252 Telecommunication FEDERAL..., Additional Provisions § 15.252 Operation of wideband vehicular radar systems within the bands 16.2-17.7 GHz...

Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects.

PubMed

Wang, Huijuan; Zhang, Pengjun; Chen, Weijun; Feng, Dan; Jia, Yanhong; Xie, Li-xin

2012-02-11

Serum microRNAs may be useful biomarkers for diagnosing human diseases. We investigated serum levels of miR-15a and miR-16 in patients with sepsis and systemic inflammatory response syndrome (SIRS) without infection. We enrolled 166 sepsis patients, 32 SIRS patients, and 24 normal controls. Serum miR-15a and miR-16 expression levels were determined by quantitative reverse transcriptase polymerase chain reaction assays (qRT-PCR). Serum miR-15a (p<0.001) and miR-16 (p<0.05) were both significantly higher in sepsis patients compared with normal controls, and miR-15a (p<0.001) and miR-16 (p<0.01) levels in SIRS patients were also significantly higher than those in normal controls. Serum miR-15a and miR-16 levels were not correlated with white blood cell counts. Receiver operating characteristic curves showed that miR-15a had the highest area under the curve of 0.858 [95% confidence interval (CI) 0.800-0.916] for the diagnosis of sepsis compared with C reactive protein and procalcitonin with areas under the curve of 0.572 (95% CI 0.479-0.665; p=0.198) and 0.605 (95% CI 0.443-0.767; p=0.168), respectively. When its cut-off point was set at 0.21, serum miR-15a had a sensitivity of 68.3% and a specificity of 94.4%. Serum miR-15a and miR-16 can both distinguish sepsis/SIRS from normal controls. miR-15a may be a biomarker that distinguishes between sepsis and SIRS.

Study of the {sup 15}N(p,gamma){sup 16}O Reaction at LUNA with a Solid Target

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capogrosso, Valentina

2010-03-01

The case of the most recent measurement performed at LUNA, the {sup 15}N(p,gamma){sup 16}O reaction, is presented. This reaction, together with the {sup 15}N(p,alpha){sup 12}C, forms the branching point from the first to the second CNO cycle and the ratio of their respective reaction rates influences the nucleosynthesis yields of {sup 16}O, {sup 17}O e {sup 17}F. In particular, one of the three different campaigns performed by the LUNA collaboration to measure the cross section of this reaction will be discussed. This experiment was performed by impinging a proton beam from the LUNA accelerator with energies ranging from 77 tomore » 350 keV in the centre-of-mass reference frame on a TiN solid target, enriched in {sup 15}N to 98%. The gamma-rays following the (p, gamma) reaction were detected by means of an high-efficiency BGO detector.« less

DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lerner, Mikael; Harada, Masako; Loven, Jakob

The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of themore » microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.« less

Teenage Thinking on Teenage Drinking: 15- to 16-Year Olds' Experiences of Alcohol in Northern Ireland

ERIC Educational Resources Information Center

McKay, Michael T.; Cole, Jon C.; Sumnall, Harry

2011-01-01

Focus groups were conducted with 15- to 16-year olds in Northern Ireland looking at reasons for alcohol consumption and reflections on specific attitudes towards alcohol and behaviours resulting from alcohol use. Participants reported greater concern with "being caught" drinking by parents than with any negative short- or long-term…

Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2).

PubMed

Jiang, P; Stone, S; Wagner, R; Wang, S; Dayananth, P; Kozak, C A; Wold, B; Kamb, A

1995-12-01

Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-beta (TGF-beta). To investigate the evolutionary and functional features of p15 and p16, we have isolated mouse (Mus musculus) homologs of each gene. Comparative analysis of these sequences provides evidence that the genes have similar functions in mouse and human. In addition, the comparison suggests that a gene conversion event is part of the evolution of the human p15 and p16 genes.

MicroSIFT Courseware Evaluations [Set 15 (362-388) and Set 16 (389-441), with an Index Listing the Contents of Each Set (Sets 1-16) and a Cumulative Subject Index (Sets 1-16)].

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR.

This document consists of 80 microcomputer software package evaluations prepared by the MicroSIFT (Microcomputer Software and Information for Teachers) Clearinghouse at the Northwest Regional Education Laboratory. Set 15 consists of 27 packages; set 16 consists of 53 packages. Each software review lists producer, time and place of evaluation,…

Does Parental Divorce Increase Risk Behaviors among 15/16 and 18/19 year-old Adolescents? A Study from Oslo, Norway.

PubMed

Zeratsion, Henok; Bjertness, Cecilie B; Lien, Lars; Haavet, Ole R; Dalsklev, Madeleine; Halvorsen, Jon A; Bjertness, Espen; Claussen, Bjørgulf

2014-01-01

Several studies have reported an increase in risk behaviors among adolescents after experience of parental divorce. The aim of the study was to investigate whether parental divorce is associated with risk behavior among adolescents independent of mental health problems, first when early divorce was experienced, and second after experience of late parental divorce. One prospective (n=1861) and one cross-sectional study (n=2422) were conducted using data from two Young-HUBRO surveys in Oslo, Norway. All 15/16 year-old 10(th) grade students who participated in the first survey in the school year 2000/01 were followed-up in 2004 when they were 18/19 year-olds. The follow-up rate was 68%. The prospective study investigated the influence of late parental divorce that occurred between the age of 15/16 and 18/19. In the cross-sectional study we focused on early parental divorce that occurred before the participants were 15/16 year-old. In the prospective study we could not discern a significant association between experiencing late parental divorce and an increase in risk behaviors among 18/19 year-old adolescents. In the cross-sectional study parental divorce was significantly associated with cigarette smoking and using doping agents. Parental divorce that occurs when the children of divorced parents are 15/16 year-old or younger is associated with an increase in cigarette smoking and use of doping agents. However, no evidence of significant association is found between experience of late parental divorce and risk behaviors in late adolescence.

Does Parental Divorce Increase Risk Behaviors among 15/16 and 18/19 year-old Adolescents? A Study from Oslo, Norway

PubMed Central

Zeratsion, Henok; Bjertness, Cecilie B; Lien, Lars; Haavet, Ole R; Dalsklev, Madeleine; Halvorsen, Jon A; Bjertness, Espen; Claussen, Bjørgulf

2014-01-01

Background: Several studies have reported an increase in risk behaviors among adolescents after experience of parental divorce. The aim of the study was to investigate whether parental divorce is associated with risk behavior among adolescents independent of mental health problems, first when early divorce was experienced, and second after experience of late parental divorce. Method: One prospective (n=1861) and one cross-sectional study (n=2422) were conducted using data from two Young-HUBRO surveys in Oslo, Norway. All 15/16 year-old 10th grade students who participated in the first survey in the school year 2000/01 were followed-up in 2004 when they were 18/19 year-olds. The follow-up rate was 68%. The prospective study investigated the influence of late parental divorce that occurred between the age of 15/16 and 18/19. In the cross-sectional study we focused on early parental divorce that occurred before the participants were 15/16 year-old. Results:In the prospective study we could not discern a significant association between experiencing late parental divorce and an increase in risk behaviors among 18/19 year-old adolescents. In the cross-sectional study parental divorce was significantly associated with cigarette smoking and using doping agents. Conclusion: Parental divorce that occurs when the children of divorced parents are 15/16 year-old or younger is associated with an increase in cigarette smoking and use of doping agents. However, no evidence of significant association is found between experience of late parental divorce and risk behaviors in late adolescence. PMID:25006342

15 CFR 90.16 - Notification of adjustment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.16 Notification of adjustment. In the event that the Director finds that the population or per capita income...

15 CFR 90.16 - Notification of adjustment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.16 Notification of adjustment. In the event that the Director finds that the population or per capita income...

15 CFR 90.16 - Notification of adjustment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.16 Notification of adjustment. In the event that the Director finds that the population or per capita income...

15 CFR 90.16 - Notification of adjustment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.16 Notification of adjustment. In the event that the Director finds that the population or per capita income...

49 CFR 172.411 - EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 2 2011-10-01 2011-10-01 false EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels..., EMERGENCY RESPONSE INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Labeling § 172.411 EXPLOSIVE 1.1, 1.2, 1.3, 1.4, 1.5 and 1.6 labels, and EXPLOSIVE Subsidiary label. (a) Except for size and color...

18 CFR 16.9 - Applications for new licenses and nonpower licenses for projects subject to sections 14 and 15 of...

Code of Federal Regulations, 2014 CFR

2014-04-01

... (except that the Director of the Office of Energy Projects may provide more than 90 days in which to... licenses and nonpower licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.9 Section 16.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF...

18 CFR 16.9 - Applications for new licenses and nonpower licenses for projects subject to sections 14 and 15 of...

Code of Federal Regulations, 2010 CFR

2010-04-01

... (except that the Director of the Office of Energy Projects may provide more than 90 days in which to... licenses and nonpower licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.9 Section 16.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF...

18 CFR 16.9 - Applications for new licenses and nonpower licenses for projects subject to sections 14 and 15 of...

Code of Federal Regulations, 2013 CFR

2013-04-01

... (except that the Director of the Office of Energy Projects may provide more than 90 days in which to... licenses and nonpower licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.9 Section 16.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF...

18 CFR 16.9 - Applications for new licenses and nonpower licenses for projects subject to sections 14 and 15 of...

Code of Federal Regulations, 2012 CFR

2012-04-01

... (except that the Director of the Office of Energy Projects may provide more than 90 days in which to... licenses and nonpower licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.9 Section 16.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF...

18 CFR 16.9 - Applications for new licenses and nonpower licenses for projects subject to sections 14 and 15 of...

Code of Federal Regulations, 2011 CFR

2011-04-01

... (except that the Director of the Office of Energy Projects may provide more than 90 days in which to... licenses and nonpower licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.9 Section 16.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF...

Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters

PubMed Central

Jordan, Paulina; Choe, Jun-Yong; Boles, Eckhard; Oreb, Mislav

2016-01-01

The genome of S. cerevisae encodes at least twenty hexose transporter-like proteins. Despite extensive research, the functions of Hxt8-Hxt17 have remained poorly defined. Here, we show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism. Moreover, Hxt11 and Hxt15 are capable of transporting xylitol, a five-carbon polyol derived from xylose, the most abundant pentose in lignocellulosic biomass. Hxt11, Hxt13, Hxt15, Hxt16 and Hxt17 are phylogenetically and functionally distinct from known polyol transporters. Based on docking of polyols to homology models of transporters, we propose the architecture of their active site. In addition, we determined the kinetic parameters of mannitol and sorbitol dehydrogenases encoded in the yeast genome, showing that they discriminate between mannitol and sorbitol to a much higher degree than the transporters. PMID:26996892

miR15a and miR16 in Chilean type 1 diabetes patients: possible association with apoptosis, inflammatory, or autoimmunity markers.

PubMed

Garcia-Diaz, D F; Camacho-Guillén, P; Codner, E; Pérez-Bravo, F

2018-01-31

Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the progressive destruction of β cells, mediated by the interaction between T cells and several cytokines. The pathogenesis of T1D has established its possible relationship with miRNAs. In this study, we analyze the expression profile of miR-15a and miR-16 in peripheral blood mononuclear cells (PBMCs) and their possible association with apoptosis, inflammation, or autoimmunity markers. 38 T1D patients and 41 control subjects were recruited. mRNAs were analyzed by means of qPCR and TaqMan probes. PBMCs were treated with different concentrations of glucose (baseline, 11 and 25 mM) with or without an inflammatory stimulus as TNF-α (10 ng/ml). A decrease in the levels of the miR-15a expression in basal conditions is observed in T1D patients compared to healthy control subjects (relative units 0.5 vs. 1.8, p < 0.05). This change in miR-15a and miR-16 is not affected by the addition of TNF-α. No association is observed with inflammatory markers (IL-6, TNF-α, vCAM) or apoptosis (bcl2 expression). The relationship with immunological markers shows an interaction effect between miR16 and IA-2 (p < 0.03). TNF-α does not affect the expression profile of miR-15a and miR16 in PBMCs. A weak correlation is observed between miR-16 and with the autoimmunity profile (IA-2 autoantibody).

miR15a and miR16 in Chilean type 1 diabetes patients: possible association with apoptosis, inflammatory, or autoimmunity markers.

PubMed

Garcia-Diaz, D F; Camacho-Guillén, P; Codner, E; Pérez-Bravo, F

2018-01-30

Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the progressive destruction of β cells, mediated by the interaction between T cells and several cytokines. The pathogenesis of T1D has established its possible relationship with miRNAs. In this study, we analyze the expression profile of miR-15a and miR-16 in peripheral blood mononuclear cells (PBMCs) and their possible association with apoptosis, inflammation, or autoimmunity markers. 38 T1D patients and 41 control subjects were recruited. mRNAs were analyzed by means of qPCR and TaqMan probes. PBMCs were treated with different concentrations of glucose (baseline, 11 and 25 mM) with or without an inflammatory stimulus as TNF-α (10 ng/ml). A decrease in the levels of the miR-15a expression in basal conditions is observed in T1D patients compared to healthy control subjects (relative units 0.5 vs. 1.8, p < 0.05). This change in miR-15a and miR-16 is not affected by the addition of TNF-α. No association is observed with inflammatory markers (IL-6, TNF-α, vCAM) or apoptosis (bcl2 expression). The relationship with immunological markers shows an interaction effect between miR16 and IA-2 (p < 0.03). TNF-α does not affect the expression profile of miR-15a and miR16 in PBMCs. A weak correlation is observed between miR-16 and with the autoimmunity profile (IA-2 autoantibody).

New astrophysical S factor for the {sup 15}N(p,{gamma}){sup 16}O reaction via the asymptotic normalization coefficient (ANC) method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukhamedzhanov, A. M.; Gagliardi, C. A.; Goldberg, V. Z.

2008-07-15

The {sup 15}N(p,{gamma}){sup 16}O reaction provides a path from the CN cycle to the CNO bi-cycle and CNO tri-cycle. The measured astrophysical factor for this reaction is dominated by resonant capture through two strong J{sup {pi}}=1{sup -} resonances at E{sub R}=312 and 962 keV and direct capture to the ground state. Asymptotic normalization coefficients (ANCs) for the ground and seven excited states in {sup 16}O were extracted from the comparison of experimental differential cross sections for the {sup 15}N({sup 3}He,d){sup 16}O reaction with distorted-wave Born approximation calculations. Using these ANCs and proton and {alpha} resonance widths determined from an R-matrixmore » fit to the data from the {sup 15}N(p,{alpha}){sup 12}C reaction, we carried out an R-matrix calculation to obtain the astrophysical factor for the {sup 15}N(p,{gamma}){sup 16}O reaction. The results indicate that the direct capture contribution was previously overestimated. We find the astrophysical factor to be S(0)=36.0{+-}6.0 keV b, which is about a factor of 2 lower than the presently accepted value. We conclude that for every 2200{+-}300 cycles of the main CN cycle one CN catalyst is lost due to this reaction.« less

Potent inhibition of endopeptidase 24.16 and endopeptidase 24.15 by the phosphonamide peptide N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid.

PubMed Central

Barelli, H; Dive, V; Yiotakis, A; Vincent, J P; Checler, F

1992-01-01

A phosphonamide peptide, N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid, previously shown to block Clostridium histolyticum collagenases, was examined as a putative inhibitor of endopeptidase 24.16 and endopeptidase 24.15. Hydrolysis of two endopeptidase 24.16 substrates, i.e. 3-carboxy-7-methoxycoumarin (Mcc)-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl (Dnp) and neurotensin, were completely and dose-dependently inhibited by the phosphonamide inhibitor with KI values of 0.3 and 0.9 nM respectively. In addition, the phosphonamide peptide inhibited the hydrolysis of benzoyl (Bz)-Gly-Ala-Ala-Phe-(pAB) p-aminobenzoate and neurotensin by endopeptidase 24.15 with about a 10-fold lower potency (KI values of 5 and 7.5 nM respectively). The selectivity of this inhibitor towards several exo- and endo-peptidases belonging to the zinc-containing metallopeptidase family established that a 1 microM concentration of this inhibitor was unable to affect leucine aminopeptidase, carboxypeptidase A, angiotensin-converting enzyme and endopeptidase 24.11. The present paper therefore reports on the first hydrophilic highly potent endopeptidase 24.16 inhibitor and describes the most potent inhibitory agent directed towards endopeptidase 24.15 developed to date. These tools should allow one to assess the contribution of endopeptidase 24.16 and endopeptidase 24.15 to the physiological inactivation of neurotensin as well as other neuropeptides. PMID:1332678

Structures, Bonding, and Energetics of Potential Triatomic Circumstellar Molecules Containing Group 15 and 16 Elements.

PubMed

Turner, Walter E; Agarwal, Jay; Schaefer, Henry F

2015-12-03

The recent discovery of PN in the oxygen-rich shell of the supergiant star VY Canis Majoris points to the formation of several triatomic molecules involving oxygen, nitrogen, and phosphorus; these are also intriguing targets for main-group synthetic inorganic chemistry. In this research, high-level ab initio electronic structure computations were conducted on the potential circumstellar molecule OPN and several of its heavier group 15 and 16 congeners (SPN, SePN, TePN, OPP, OPAs, and OPSb). For each congener, four isomers were examined. Optimized geometries were obtained with coupled cluster theory [CCSD(T)] using large Dunning basis sets [aug-cc-pVQZ, aug-cc-pV(Q+d)Z, and aug-cc-pVQZ-PP], and relative energies were determined at the complete basis set limit of CCSDT(Q) from focal point analyses. The linear phosphorus-centered molecules were consistently the lowest in energy of the group 15 congeners by at least 6 kcal mol(-1), resulting from double-triple and single-double bond resonances within the molecule. The linear nitrogen-centered molecules were consistently the lowest in energy of the group 16 congeners by at least 5 kcal mol(-1), due to the electronegative central nitrogen atom encouraging electron delocalization throughout the molecule. For OPN, OPP, and SPN, anharmonic vibrational frequencies and vibrationally corrected rotational constants are predicted; good agreement with available experimental data is observed.

15 CFR Supplement No. 16 to Part 760 - Interpretation

Code of Federal Regulations, 2014 CFR

2014-01-01

... Articles 5, 7, and 26 of the Treaty of Peace between the State of Israel and the Hashemite Kingdom of... boycott of Israel was formally terminated on August 16, 1995. On the basis of this action, it is the... in force against Israel. Such a request from Jordan after August 16, 1995 would not be presumed...

15 CFR Supplement No. 16 to Part 760 - Interpretation

Code of Federal Regulations, 2013 CFR

2013-01-01

... Articles 5, 7, and 26 of the Treaty of Peace between the State of Israel and the Hashemite Kingdom of... boycott of Israel was formally terminated on August 16, 1995. On the basis of this action, it is the... in force against Israel. Such a request from Jordan after August 16, 1995 would not be presumed...

15 CFR Supplement No. 16 to Part 760 - Interpretation

Code of Federal Regulations, 2012 CFR

2012-01-01

... Articles 5, 7, and 26 of the Treaty of Peace between the State of Israel and the Hashemite Kingdom of... boycott of Israel was formally terminated on August 16, 1995. On the basis of this action, it is the... in force against Israel. Such a request from Jordan after August 16, 1995 would not be presumed...

15 CFR Supplement No. 16 to Part 760 - Interpretation

Code of Federal Regulations, 2011 CFR

2011-01-01

... Articles 5, 7, and 26 of the Treaty of Peace between the State of Israel and the Hashemite Kingdom of... boycott of Israel was formally terminated on August 16, 1995. On the basis of this action, it is the... in force against Israel. Such a request from Jordan after August 16, 1995 would not be presumed...

15 CFR Supplement No. 16 to Part 760 - Interpretation

Code of Federal Regulations, 2010 CFR

2010-01-01

... Articles 5, 7, and 26 of the Treaty of Peace between the State of Israel and the Hashemite Kingdom of... boycott of Israel was formally terminated on August 16, 1995. On the basis of this action, it is the... in force against Israel. Such a request from Jordan after August 16, 1995 would not be presumed...

Endopeptidases 24.16 and 24.15 are responsible for the degradation of somatostatin, neurotensin, and other neuropeptides by cultivated rat cortical astrocytes.

PubMed

Mentlein, R; Dahms, P

1994-01-01

Several neuropeptides, including neurotensin, somatostatin, bradykinin, angiotensin II, substance P, and luteinizing hormone-releasing hormone but not vasopressin and oxytocin, were actively metabolized through proteolytic degradation by cultivated astrocytes obtained from rat cerebral cortex. Because phenanthroline was an effective degradation inhibitor, metalloproteases were responsible for neuropeptide fragmentation. Neurotensin was cleaved by astrocytes at the Pro10-Tyr11 and Arg8-Arg9 bonds, whereas somatostatin was cleaved at the Phe6-Phe7 and Thr10-Phe11 bonds. These cleavage sites have been found previously with endopeptidases 24.16 and 24.15 purified from rat brain. Addition of specific inhibitors of these proteases, the dipeptide Pro-Ile and N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-4-aminobenzoate, significantly reduced the generation of the above neuropeptide fragments by astrocytes. The presence of endopeptidases 24.16 and 24.15 in homogenates of astrocytes could also be demonstrated by chromatographic separations of supernatant solubilized cell preparations. Proteolytic activity for neurotensin eluted after both gel and hydroxyapatite chromatography at the same positions as found for purified endopeptidase 24.16 or 24.15. In incubation experiments or in chromatographic separations no phosphoramidon-sensitive endopeptidase 24.11 (enkephalinase) or captopril-sensitive peptidyl dipeptidase A (angiotensin-converting enzyme) could be detected in cultivated astrocytes. Because astrocytes embrace the neuronal synapses where neuropeptides are released, we presume that the endopeptidases 24.16 and 24.15 on astrocytes are strategically located to contribute significantly to the inactivation of neurotensin, somatostatin, and other neuropeptides in the brain.

Lunar surface radioactivity: preliminary results of the apollo 15 and apollo 16 gamma-ray spectrometer experiments.

PubMed

Metzger, A E; Trombka, J I; Peterson, L E; Reedy, R C; Arnold, J R

1973-02-23

Gamma-ray spectrometers on the Apollo 15 and Apollo 16 missions have been used to map the moon's radioactivity over 20 percent of its surface. The highest levels of natural radioactivity are found in Mare Imbrium and Oceanus Procellarum with contrastingly lower enhancements in the eastern maria. The ratio of potassium to uranium is higher on the far side than on the near side, although it is everywhere lower than commonly found on the earth.

Lunar surface radioactivity - Preliminary results of the Apollo 15 and Apollo 16 gamma-ray spectrometer experiments.

NASA Technical Reports Server (NTRS)

Metzger, A. E.; Trombka, J. I.; Peterson, L. E.; Reedy, R. C.; Arnold, J. R.

1973-01-01

Gamma-ray spectrometers on the Apollo 15 and Apollo 16 missions have been used to map the moon's radioactivity over 20 percent of its surface. The highest levels of natural radioactivity are found in Mare Imbrium and Oceanus Procellarum with contrastingly lower enhancements in the eastern maria. The ratio of potassium to uranium is higher on the far side than on the near side, although it is everywhere lower than commonly found on the earth.

The E. coli 16S rRNA binding site of ribosomal protein S15: higher-order structure in the absence and in the presence of the protein.

PubMed Central

Mougel, M; Philippe, C; Ebel, J P; Ehresmann, B; Ehresmann, C

1988-01-01

We have investigated in detail the secondary and tertiary structures of E. coli 16S rRNA binding site of protein S15 using a variety of enzymatic and chemical probes. RNase T1 and nuclease S1 were used to probe unpaired nucleotides and RNase V1 to monitor base-paired or stacked nucleotides. Bases were probed with dimethylsulfate (at A(N-1), C(N-3) and G(N-7)), with 1-cyclohexyl-3 (2-(1-methylmorpholino)-ethyl)-carboiimide-p- toluenesulfonate (at U(N-3) and G(N-1)) and with diethylpyrocarbonate (at A(N-7)). The RNA region corresponding to nucleotides 652 to 753 was tested within: (1) the complete 16S rRNA molecule; (2) a 16S rRNA fragment corresponding to nucleotides 578 to 756 obtained by transcription in vitro; (3) the S15-16S rRNA complex; (4) the S15-fragment complex. Cleavage and modification sites were detected by primer extension with reverse transcriptase. Our results show that: (1) The synthetized fragment folds into the same overall secondary structure as in the complete 16S rRNA, with the exception of the large asymmetrical internal loop (nucleotides 673-676/714-733) which is fully accessible in the fragment while it appears conformationally heterogeneous in the 16S rRNA; (2) the reactivity patterns of the S15-16S rRNA and S15-fragment complexes are identical; (3) the protein protects defined RNA regions, located in the large interior loop and in the 3'-end strand of helix [655-672]-[734-751]; (4) the protein also causes enhanced chemical reactivity and enzyme accessibility interpreted as resulting from a local conformational rearrangement, induced by S15 binding. Images PMID:2453025

Ten-year immune persistence and safety of the HPV-16/18 AS04-adjuvanted vaccine in females vaccinated at 15-55 years of age.

PubMed

Schwarz, Tino F; Galaj, Andrzej; Spaczynski, Marek; Wysocki, Jacek; Kaufmann, Andreas M; Poncelet, Sylviane; Suryakiran, Pemmaraju V; Folschweiller, Nicolas; Thomas, Florence; Lin, Lan; Struyf, Frank

2017-11-01

Women remain at risk of human papillomavirus (HPV) infection for most of their lives. The duration of protection against HPV-16/18 from prophylactic vaccination remains unknown. We investigated the 10-year immune response and long-term safety profile of the HPV-16/18 AS04-adjuvanted vaccine (AS04-HPV-16/18 vaccine) in females aged between 15 and 55 years at first vaccination. Females who received primary vaccination with three doses of AS04-HPV-16/18 vaccine in the primary phase-III study (NCT00196937) were invited to attend annual evaluations for long-term immunogenicity and safety. Anti-HPV-16/18 antibodies in serum and cervico-vaginal secretions (CVS) were measured using enzyme-linked immunosorbent assay (ELISA). Serious adverse events (SAEs) were recorded throughout the follow-up period. Seropositivity rates for anti-HPV-16 remained high (≥96.3%) in all age groups 10 years after first vaccination. It was found that 99.2% of 15-25-year olds remained seropositive for anti-HPV-18 compared to 93.7% and 83.8% of 26-45-year olds and 45-55-year olds, respectively. Geometric mean titers (GMT) remained above natural infection levels in all age groups. Anti-HPV-16 and anti-HPV-18 titers were at least 5.3-fold and 3.1-fold higher than titers observed after natural infection, respectively, and were predicted to persist above natural infection levels for ≥30 years in all age groups. At Year 10, anti-HPV-16/18 antibody titers in subjects aged 15-25 years remained above plateau levels observed in previous studies. Correlation coefficients for antibody titers in serum and CVS were 0.64 (anti-HPV-16) and 0.38 (anti-HPV-18). This study concluded that vaccinated females aged 15-55 years elicited sustained immunogenicity with an acceptable safety profile up to 10 years after primary vaccination, suggesting long-term protection against HPV. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Ethnic and Gender Differences in Drinking, Smoking and Drug Taking among Adolescents in England: A Self-Report School-Based Survey of 15 and 16 Year Olds

ERIC Educational Resources Information Center

Rodham, Karen; Hawton, Keith; Evans, Emma; Weatherall, Rosamund

2005-01-01

Concern has been mounting about the increasing numbers of adolescents who (ab)use drugs, alcohol and cigarettes. The aim of this study was to establish the prevalence according to gender and ethnicity of drinking, smoking and drug-use in a representative sample of 15 and 16 year olds. The sample consisted of 6020 15- and 16-year-old pupils from 41…

Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in Autism Spectrum Disorder Brazilian Individuals with and without Epilepsy

PubMed Central

Moreira, Danielle P.; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L.; Lourenço, Naila C. V.; Takahashi, Vanessa N. O.; da Rocha, Kátia M.; Moreira, Eloisa S.; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; Halloran, Eoghan O’; Magalhães, Tiago R.; Fett-Conte, Agnes C.; Passos-Bueno, Maria Rita

2014-01-01

Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy. PMID:25255310

Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy.

PubMed

Moreira, Danielle P; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L; Lourenço, Naila C V; Takahashi, Vanessa N O; da Rocha, Kátia M; Moreira, Eloisa S; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; O'Halloran, Eoghan; Magalhães, Tiago R; Fett-Conte, Agnes C; Passos-Bueno, Maria Rita

2014-01-01

Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy.

Cosmic ray exposure histories of Apollo 14, Apollo 15, and Apollo 16 rocks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eugster, O.; Eberhardt, P.

1984-02-15

The regolith exposure history of six rocks returned by the Apollo 14, 15, and 16 missions is studied based on the cosmogenic noble gas isotopes. For each sample, the complete set of all stable noble gas isotopes and the radiaoctive isotope Kr-81 were measured. Kr-81-Kr exposure ages are calculated for rocks for which a single-stage exposure can be demonstrated. A two-stage model exposure history is derived for multistage-exposure basalt 14310 based on the amounts and isotopic ratios of the cosmogenic noble gases. The apparent Kr-81-Kr age, the depth-sensitive isostopic ratios, and fission Xe-136 results lead to the conclusion that thismore » sample was preexposed 1.75 AE ago to cosmic rays for a duration of 350 m.y. Basalt 15058 and anorthosite 15415 also reveal multistage exposures. 44 references.« less

16 CFR Figures 14 and 15 to Part 1633 - Label for Domestic Mattress Alone and with Foundation and Label for Imported Mattress Alone and...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Label for Domestic Mattress Alone and with Foundation and Label for Imported Mattress Alone and With Foundation 14 Figures 14 and 15 to Part 1633... FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Figs. 14, 15 Figures 14 and 15 to Part 1633—Label for...

16 CFR Figures 14 and 15 to Part 1633 - Label for Domestic Mattress Alone and with Foundation and Label for Imported Mattress Alone and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Label for Domestic Mattress Alone and with Foundation and Label for Imported Mattress Alone and With Foundation 14 Figures 14 and 15 to Part 1633... FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Figs. 14, 15 Figures 14 and 15 to Part 1633—Label for...

15 CFR 16.9 - Rules governing designated agents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... representation; and (3) Agree to service any participant in this program in the agent's cognizant product area... participants that the designated agent services under the program. The Secretary shall also be provided an... transmit those fees and charges required under § 16.6 to the Secreatry; (3) Distribute Department of...

15 CFR 16.9 - Rules governing designated agents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... representation; and (3) Agree to service any participant in this program in the agent's cognizant product area... participants that the designated agent services under the program. The Secretary shall also be provided an... transmit those fees and charges required under § 16.6 to the Secreatry; (3) Distribute Department of...

Origin of 10{sup 15}–10{sup 16} G magnetic fields in the central engine of gamma ray bursts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Souza, Rafael S. de; Opher, Reuven, E-mail: rafael@astro.iag.usp.br, E-mail: opher@astro.iag.usp.br

2010-02-01

Various authors have suggested that the gamma-ray burst (GRB) central engine is a rapidly rotating, strongly magnetized, ( ∼ 10{sup 15}–10{sup 16} G) compact object. The strong magnetic field can accelerate and collimate the relativistic flow and the rotation of the compact object can be the energy source of the GRB. The major problem in this scenario is the difficulty of finding an astrophysical mechanism for obtaining such intense fields. Whereas, in principle, a neutron star could maintain such strong fields, it is difficult to justify a scenario for their creation. If the compact object is a black hole, themore » problem is more difficult since, according to general relativity it has ''no hair'' (i.e., no magnetic field). Schuster, Blackett, Pauli, and others have suggested that a rotating neutral body can create a magnetic field by non-minimal gravitational-electromagnetic coupling (NMGEC). The Schuster-Blackett form of NMGEC was obtained from the Mikhail and Wanas's tetrad theory of gravitation (MW). We call the general theory NMGEC-MW. We investigate here the possible origin of the intense magnetic fields ∼ 10{sup 15}–10{sup 16} G in GRBs by NMGEC-MW. Whereas these fields are difficult to explain astrophysically, we find that they are easily explained by NMGEC-MW. It not only explains the origin of the ∼ 10{sup 15}–10{sup 16} G fields when the compact object is a neutron star, but also when it is a black hole.« less

Chemical composition and deterioration of glass excavated in the 15th 16th century fishermen town of Raversijde (Belgium)

NASA Astrophysics Data System (ADS)

Schalm, O.; Caluwé, D.; Wouters, H.; Janssens, K.; Verhaeghe, F.; Pieters, M.

2004-10-01

The chemical composition, as determined by electron probe X-ray microanalysis of a series of ca. 100 archaeological glass fragments, excavated at the Raversijde site (Belgium) is discussed. In the 15th-16th century, Raversijde was a flourishing fishermen town located on the shore of the North Sea, close to the city of Ostend. As a consequence of several battles that were fought in its vicinity, the site was abandoned in the 16th century and was not occupied since then. It is one of the rare archaeological sites in Europe that contains a significant amount of information on the daily life inside a small but affluent medieval community. A comparison of the chemical composition of fragments of vessels and window glass encountered in Raversijde to those found in urban centres in Belgium and to literature date on German and French archaeological finds shows that glass made with wood ash dominates. Usually, it concerns artifacts with a predominantly utilitarian use. A few objects made with sodic (i.e., Na-rich) glass were also encountered, likely to have been imported from Venice during the 15th century or in later periods from an urban centre such as Antwerp, where Façon-de-Venice glass manufacturing activities were established near the start of the 16th century.

Layer structure of the Venus daytime ionosphere from Venera-15,-16 radio occultation

NASA Astrophysics Data System (ADS)

Gavrik, Anatoly

Up to now more than five hundred radio occultation experiments had been carried out by different missions to research physical properties of the Venus ionosphere. The purpose of this report is to show new properties of the Venus daytime ionosphere reanalyzing Venera-15,-16 dual-frequency occultation data. The high coherence and stability of radio signals of Venera- 15,-16 at wave lengths 32 cm and 8 cm, along with the fact, that the refractive amplification at 32 cm in the ionosphere exceeds by factor 6 the refractive amplification at 13 cm used by others researches, have allowed to perform analysis of radiophysical parameters in the Venus ionosphere more accurate. Progress in the radiovision theory and up-to-date digital processing techniques have provided an opportunity to discover unknown layered structure of the Venus daytime ionosphere. We offer the new technique of the data analysis that allows us to separate influence of noise, ionosphere and atmosphere on the radio occultation results. We point out that significant gradient variations in the vertical distribution of the electron density are observed in the region of maximum electron density of the daytime ionosphere at altitudes of 150-175 km. That testifies layered structure of this part of the Venus ionosphere. The results of data analysis reveal the regular existence of the ionospheric layers in the bottom daytime ionosphere at altitudes from 80 up to 115 km. The bottom border of the ionosphere part can vary in the range of 80-100 km, and gradients of the electron density show strong variability. We detect the wave structure in the top atmosphere and in the bottom ionosphere at altitudes from 60 up to 115 km as well. It is difficult to obtain correct electron density in the region, where we have detected the new ionospheric layers. Relative errors of the electron density are greater than 100% at altitudes between 80 and 120 km. The bottom part of the ionosphere is more variable, than overlying area of

Spectroscopic and microbiological characterization of labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione isolated from the stems of Croton jacobinensis

NASA Astrophysics Data System (ADS)

Bernardino, A. C. S. S.; Teixeira, A. M. R.; de Menezes, J. E. S. A.; Pinto, C. C. C.; Santos, H. S.; Freire, P. T. C.; Coutinho, H. D. M.; Sena Junior, D. M.; Bandeira, P. N.; Braz-Filho, R.

2017-11-01

In the present study, the natural product named 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione (C20H28O4), a labdane-type diterpene was isolated from the stems of Croton jacobinensis for the first time. This new compound was characterized by infrared and Raman spectroscopy combined with Density Functional Theory calculation. Additionally, the antimicrobial and modulatory antibiotic activities of the compound towards Escherichia coli and Pseudomonas aeruginosa strains were assessed. The labdane diterpene demonstrated a modulatory effect when combined with the antibiotics assayed against both bacteria. A synergistic effect against Escherichia coli can be observed when the compound is associated with gentamicin, reducing the concentration of this antibiotic that is required to inhibit bacterial growth. Other synergistic effects can be observed with gentamicin and cephalothin antibiotics against P. aeruginosa.

18 CFR 16.21 - Operation of projects with a minor or minor part license not subject to sections 14 and 15 of the...

Code of Federal Regulations, 2010 CFR

2010-04-01

... with a minor or minor part license not subject to sections 14 and 15 of the Federal Power Act after... TAKEOVER AND RELICENSING OF LICENSED PROJECTS Projects With Minor and Minor Part Licenses Not Subject to Sections 14 and 15 of the Federal Power Act § 16.21 Operation of projects with a minor or minor part...

18 CFR 16.21 - Operation of projects with a minor or minor part license not subject to sections 14 and 15 of the...

Code of Federal Regulations, 2011 CFR

2011-04-01

... with a minor or minor part license not subject to sections 14 and 15 of the Federal Power Act after... TAKEOVER AND RELICENSING OF LICENSED PROJECTS Projects With Minor and Minor Part Licenses Not Subject to Sections 14 and 15 of the Federal Power Act § 16.21 Operation of projects with a minor or minor part...

Synthesis of a new allelopathic agent from the biotransformation of ent-15α-hydroxy-16-kauren-19-oic acid with Fusarium proliferatum.

PubMed

Rocha, A D; Vieira, H da S; Takahashi, J A; Boaventura, M A D

2017-11-01

The use of kaurane diterpenes as substrates in fungal biotransformation to achieve bioactive compounds has been widely reported. In this work, the natural product kaurenoic acid, a diterpene widely distributed in the plant Kingdom, was chemically converted into ent-15α-hydroxy-kaur-16-en-19-oic acid (1). Substrate 1 was subjected to biotransformation by the fungus Fusarium proliferatum, furnishing a new derivative, ent-2α,15α-dihydroxy-kaur-16-en-19-oic acid (2). The structure of metabolite 2 was deduced on the basis of spectroscopy and MS data. Derivative 2 showed allelopathic activity on germination and growth of root and stem of lettuce (Lactuca sativa), inhibiting 100% of germination and growth of roots and stem, at higher concentration assayed (10 -4  mol/L).

Bulk, rare earth and other trace elements in Apollo 14 and 15 and Luna 16 samples

NASA Technical Reports Server (NTRS)

Laul, J. C.; Wakita, H.; Showalter, D. L.; Boynton, W. V.; Schmitt, R. A.

1971-01-01

The chemical abundances were measured by instrumental and radiochemical neutron activation analysis in a variety of lunar specimens. Apollo 14 soils are characterized by significant enrichments of Al2O3, Na2O and K2O and depletions of TiO2, FeO, MnO and Cr2O3 relative to Apollo 11 and to most of Apollo 12 soils. The uniform abundances in 14230 core tube soils and three other Apollo 14 soils indicate that the regolith is uniform to at least 22 cm depth and within approximately 200 m from the lunar module. Two Luna 16 breccias are similar in composition to Luna 16 soils. Four Apollo 15 soils (LM, STA 4, 9, and 9a) have variable compositions. Interelement correlations between MnO-FeO, Sc-FeO, V-Cr2O3 and K2O-Hf negate the hypothesis that howardite achondrites may be primitive lunar matter, argue against the fission hypothesis for the origin of the moon, and precludes any selective large scale volatilization of alkalies during lunar magmatic events.

Alcohol consumption at age 11-12 years and traumatic dental injuries at age 15-16 years in school children from East London.

PubMed

Baig Enver, Muneera; Marcenes, Wagner; Stansfeld, Stephen A; Bernabé, Eduardo

2016-10-01

To explore the association between alcohol consumption at age 11-12 years and traumatic dental injuries (TDI) at age 15-16 years. Data of 635 adolescents who participated in phases I and III of the Research with East London Adolescents Community Health Survey (RELACHS), a longitudinal school-based survey of a representative sample of adolescents from East London, were used for this study. Information on socio-demographic characteristics and alcohol consumption was obtained from questionnaires in phase I when adolescents were 11-12 years of age. Data on TDI and clinical characteristics (incisor overjet and lip coverage) were taken from clinical examination in phase III when adolescents were 15-16 years of age. The association between (lifetime and last month) alcohol consumption and TDI was assessed in crude and adjusted logistic regression models. Overall, 14.5% of adolescents had ever consumed alcohol and 3.5% had consumed alcohol the month before the baseline survey, whereas 17% of adolescents had experienced TDI by age 15-16 years. No significant association of alcohol consumption with TDI was seen in these adolescents for either lifetime (adjusted odds ratio [OR]: 0.87; 95% confidence interval [CI]: 0.45-1.67) or last month consumption of alcohol (adjusted OR: 0.86; 95% CI: 0.28-2.69). This study did not support the association between alcohol use and TDI in adolescents. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Specific recognition of rpsO mRNA and 16S rRNA by Escherichia coli ribosomal protein S15 relies on both mimicry and site differentiation.

PubMed

Mathy, Nathalie; Pellegrini, Olivier; Serganov, Alexander; Patel, Dinshaw J; Ehresmann, Chantal; Portier, Claude

2004-05-01

The ribosomal protein S15 binds to 16S rRNA, during ribosome assembly, and to its own mRNA (rpsO mRNA), affecting autocontrol of its expression. In both cases, the RNA binding site is bipartite with a common subsite consisting of a G*U/G-C motif. The second subsite is located in a three-way junction in 16S rRNA and in the distal part of a stem forming a pseudoknot in Escherichia coli rpsO mRNA. To determine the extent of mimicry between these two RNA targets, we determined which amino acids interact with rpsO mRNA. A plasmid carrying rpsO (the S15 gene) was mutagenized and introduced into a strain lacking S15 and harbouring an rpsO-lacZ translational fusion. Analysis of deregulated mutants shows that each subsite of rpsO mRNA is recognized by a set of amino acids known to interact with 16S rRNA. In addition to the G*U/G-C motif, which is recognized by the same amino acids in both targets, the other subsite interacts with amino acids also involved in contacts with helix H22 of 16S rRNA, in the region adjacent to the three-way junction. However, specific S15-rpsO mRNA interactions can also be found, probably with A(-46) in loop L1 of the pseudoknot, demonstrating that mimicry between the two targets is limited.

18 CFR 16.16 - Motion for stay by Federal department or agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Motion for stay by... 15 of the Federal Power Act § 16.16 Motion for stay by Federal department or agency. (a) Within 30... or agency that has filed a takeover recommendation under § 16.14 may file a motion under § 385.212 of...

Comparison of Quantity Versus Quality Using Performance, Reliability, and Life Cycle Cost Data. A Case Study of the F-15, F-16, and A-10 Aircraft.

DTIC Science & Technology

1985-09-01

CoC S~04 COMPARISON OF QUANTITY VERSUS QUALITY USING PERFORMANCE, RELIABILITY, AND LIFE CYCLE COST DATA. A CASE STUDY OF THE F-15, F-16, AND A-10...CYCLE COSTIATU.AT CAE AIR ORE HEO OG .- jAITR UIVERSITY W right.,Patterson Air Force Base, Ohio .! 5ൔ ,6 198 C.IT. U AF’IT/GSL,4/L3Q/65:S Ŗ J...COMPARISON OF QUANTITY VERSUS QUALITY USING PERFORMANCE, RELIABILITY, AND LIFE CYCLE COST DATA. A CASE STUDY OF THE F-15, F-16, AND A-10 AIRCRAFT THESIS David

16 CFR 1115.15 - Confidentiality and disclosure of data.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Confidentiality and disclosure of data. 1115... and disclosure of data. (a) General. The Commission does not routinely make reports available to the... information is entitled to exemption from public disclosure under the provisions of the Freedom of Information...

16 CFR 1115.15 - Confidentiality and disclosure of data.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Confidentiality and disclosure of data. 1115... and disclosure of data. (a) General. The Commission does not routinely make reports available to the... information is entitled to exemption from public disclosure under the provisions of the Freedom of Information...

16 CFR 1115.15 - Confidentiality and disclosure of data.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Confidentiality and disclosure of data. 1115... and disclosure of data. (a) General. The Commission does not routinely make reports available to the... information is entitled to exemption from public disclosure under the provisions of the Freedom of Information...

16 CFR 1115.15 - Confidentiality and disclosure of data.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Confidentiality and disclosure of data. 1115... and disclosure of data. (a) General. The Commission does not routinely make reports available to the... information is entitled to exemption from public disclosure under the provisions of the Freedom of Information...

Pervasive Layering in the Lunar Highland Crust: Evidence from Apollos 15, 16,and 17

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.; Yang, Tiffany

2005-01-01

This paper presents results of a photogeologic reconnaissance of 70 mm photographs taken on the lunar surface during the Apollo 15, 16, and 17 missions, whose primary objective was to investigate the lunar highland crust. Photographs at all three sites, notably the Apennine Front, show pervasive layered structure. These layers are easily distinguished from lighting artifacts, and are considered genuine crustal structures. Their number, thickness, and extent implies that they are lava flows, not ejecta blankets or intrusive features. They appear to be the upper part of the earliest lunar crust, possibly forming a layer tens of kilometers thick. Remote sensing studies (X-ray fluorescence and reflectance spectroscopy), indicate that the highland crust is dominantly a feldspathic basalt. It is concluded that the highland layers represent a global crust formed by eruptions of high-alumina basalt in the first few hundred million years of the Moon's history.

Specific recognition of rpsO mRNA and 16S rRNA by Escherichia coli ribosomal protein S15 relies on both mimicry and site differentiation

PubMed Central

Mathy, Nathalie; Pellegrini, Olivier; Serganov, Alexander; Patel, Dinshaw J.; Ehresmann, Chantal; Portier, Claude

2015-01-01

Summary The ribosomal protein S15 binds to 16S rRNA, during ribosome assembly, and to its own mRNA (rpsO mRNA), affecting autocontrol of its expression. In both cases, the RNA binding site is bipartite with a common subsite consisting of a G•U/G-C motif. The second subsite is located in a three-way junction in 16S rRNA and in the distal part of a stem forming a pseudoknot in Escherichia coli rpsO mRNA. To determine the extent of mimicry between these two RNA targets, we determined which amino acids interact with rpsO mRNA. A plasmid carrying rpsO (the S15 gene) was mutagenized and introduced into a strain lacking S15 and harbouring an rpsO–lacZ translational fusion. Analysis of deregulated mutants shows that each subsite of rpsO mRNA is recognized by a set of amino acids known to interact with 16S rRNA. In addition to the G•U/G-C motif, which is recognized by the same amino acids in both targets, the other subsite interacts with amino acids also involved in contacts with helix H22 of 16S rRNA, in the region adjacent to the three-way junction. However, specific S15–rpsO mRNA interactions can also be found, probably with A(−46) in loop L1 of the pseudoknot, demonstrating that mimicry between the two targets is limited. PMID:15101974

F-16XL ship #1 CAWAP flight - alpha 15 degrees, altitude 5,000 feet

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. This photo shows the aircraft gathering data at an altitude of 5000 feet, with an angle of attack of 15 degrees. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

High-Resolution Analysis of the ν 6, ν 7, ν 8, and ν 9Bands of H 15N 16O 3Measured by Fourier Transform Spectroscopy

NASA Astrophysics Data System (ADS)

Keller, F.; Perrin, A.; Flaud, J.-M.; Johns, J. W. C.; Lu, Z.; Looi, E. C.

1998-10-01

The analysis of the ν6, ν7, ν8, and ν9bands of H15N16O3located at 646.9641, 578.4719, 743.6166, and 458.2917 cm-1, respectively, has been carried out in the 400-800 cm-1region using high-resolution Fourier transform spectra recorded at Ottawa. Using the ground state energy levels calculated from thev= 0 rotational constants of H15N16O3[A. P. Cox, M. C. Ellis, C. J. Attfield, and A. C. Ferris,J. Mol. Struct.320, 91-106 (1994)], it was possible to assign theA-type ν6and ν7bands and theC-type ν8and ν9bands of H15N16O3up to highJandKarotational quantum numbers. Thev6= 1,v7= 1, v8= 1, andv9= 1 experimental energy levels were then introduced in a least-squares fit calculation and precise upper state Hamiltonian constants (band centers and rotational constants) were determined allowing one to reproduce the infrared data to within the experimental uncertainty.

Tectonic interpretations of Central Ishtar Terra (Venus) from Venera 15/16 and Magellan full-resolution radar images

NASA Astrophysics Data System (ADS)

Ansan, V.; Vergely, P.; Masson, P.

1994-03-01

For more than a decade, the mapping of Venus has revealed a surface that has had a complex volcanic and tectonic history, especially in the northern latitudes. Detailed morphostructural analysis and tectonic interpretations of Central Ishtar Terra, based both on Venera 15/16 and Magellan full-resolution radar images, have provided additional insight to the formation and evolution of Venusian terrains. Ishtar Terra, centered at 0 deg E longitude and 62 deg N latitude, consists of a broad high plateau, Lakshmi Planum, partly surrounded by two highlands, Freyja and Maxwell Montes, which have been interpreted as orogenic belts based on Venera 15 and 16 data. Lakshmi Planum, the oldest part of Ishtar Terra, is an extensive and complexly fractured plateau that can be compared to a terrestrial craton. The plateau is partially covered by fluid lava flows similar to the Deccan traps in India, which underwent a late stage of extensional fracturing. After the extensional deformation of Lakshmi Planum, Freyja and Maxwell Montes were created by regional E-W horizontal shortening that produced a series of N-S folds and thrusts. However, this regional arrangement of folds and thrusts is disturbed locally, e.g. the compressive deformation of Freyja Montes was closely controlled by parallel WNW-ESE-trending left-lateral shear zones and the northwestern part of Maxwell Montes seems to be extruded laterally to the southwest, which implies a second oblique thrust front overlapping Lakshmi Planum. These mountain belts also shows evidence of a late volcanic stage and a subsequent period of relaxation that created grabens parallel to the highland trends, especially in Maxwell Montes.

Methylation of CpG island of p14(ARK), p15(INK4b) and p16(INK4a) genes in coke oven workers.

PubMed

Zhang, H; Li, X; Ge, L; Yang, J; Sun, J; Niu, Q

2015-02-01

To detect the blood genomic DNA methylation in coke oven workers and find a possible early screening index for occupational lung cancer, 74 coke oven workers as the exposed group and 47 water pump workers as the controls were surveyed, and urine samples and peripheral blood mononuclear cells (PBMCs) were collected. Airborne benzo[a]pyrene (B[a]P) levels in workplace and urinary 1-hydroxypyrene (1-OH-Py) levels were determined by high-performance liquid chromatography. DNA damage of PBMCs and the p14(ARK), p15(INK4b) and p16(INK4a) gene CpG island methylation in the promoter region were detected by comet assay and methylation-specific polymerase chain reaction techniques, respectively. Results show that compared with the controls, concentration of airborne B[a]Ps was elevated in the coke plant, and urinary 1-OH-Py's level and DNA olive tail moment in comet assay were significantly increased in the coke oven workers, and p14(ARK), p15(INK4b) and p16(INK4a) gene methylation rates were also significantly increased. With the working years and urinary 1-OH-Py's level, the rates of p14(ARK) and p16(INK4a) gene methylation were significantly increased while that of p15(INK4b) gene methylation displayed no statistical change. We conclude that PBMCs' p14(ARK) and p16(INK4a) gene methylation may be used for screening and warning lung cancer in coke oven workers. © The Author(s) 2015.

Identifying CNVs in 15q11q13 and 16p11.2 of Patients with Seizures Increases the Rates of Detecting Pathogenic Changes

PubMed Central

Vianna, Gabrielle S.; Freitas, Mariana L.; Oliveira, Valdirene T.de; Pietra, Rafaella X.; Gonçalves, Michele da S.; Rocha, Patrícia P.O.; Monteiro, Rejane A.C.; Ferreira, Luana C.A.; Xavier, Rosana R.; Carvalho, Andréia M.; Lima, Patrícia R. de M.; Monteiro, Maria Augusta N.P.; Mateo, Elvis C.; Giannetti, Juliana G.; César, Giovana da C.; Lima, Joziele de S.; Medeiros, Paula F.V.; Jehee, Fernanda S.

2016-01-01

Chromosomal changes are frequently observed in patients with syndromic seizures. Understanding the genetic etiology of this pathology is crucial for the guidance and genetic counseling of families as well as for the establishment of appropriate treatment. A combination of MLPA kits was used to identify pathogenic CNVs in a group of 70 syndromic patients with seizures. Initially, a screening was performed for subtelomeric changes (MLPA P036 and P070 kits) and for the regions most frequently related to microdeletion/microduplication syndromes (MLPA P064). Subsequently, the MLPA P343 was used to identify alterations in the 15q11q13, 16p11.2, and 22q13 regions. Screening with MLPA P343 allowed a 10-15.7% increase in the detection rate of CNVs reinforcing the importance of investigating changes in 15q11q13 and 16p11.2 in syndromic patients with seizures. We also demonstrated that the MLPA technique is an alternative with a great diagnostic potential, and we proposed its use as part of the initial assessment of syndromic patients with seizures. PMID:27920636

29 CFR 511.16 - Reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Reports. 511.16 Section 511.16 Labor Regulations Relating... AMERICAN SAMOA § 511.16 Reports. Promptly after receipt of submissions under § 511.15, the committee or subcommittee will resolve the issues before it and prepare a report containing its findings of fact and...

29 CFR 511.16 - Reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Reports. 511.16 Section 511.16 Labor Regulations Relating... AMERICAN SAMOA § 511.16 Reports. Promptly after receipt of submissions under § 511.15, the committee or subcommittee will resolve the issues before it and prepare a report containing its findings of fact and...

29 CFR 511.16 - Reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Reports. 511.16 Section 511.16 Labor Regulations Relating... AMERICAN SAMOA § 511.16 Reports. Promptly after receipt of submissions under § 511.15, the committee or subcommittee will resolve the issues before it and prepare a report containing its findings of fact and...

Astrophysical S factor for the {sup 15}N(p,{gamma}){sup 16}O reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukhamedzhanov, A. M.; La Cognata, M.; Kroha, V.

2011-04-15

The R-matrix approach has proved to be very useful in extrapolating the astrophysical factor down to astrophysically relevant energies, since the majority of measurements are not available in this region. However, such an approach has to be critically considered when no complete knowledge of the reaction model is available. To get reliable results in such cases one has to use all the available information from independent sources and, accordingly, fix or constrain variations of the parameters. In this paper we present a thorough R-matrix analysis of the {sup 15}N(p,{gamma}){sup 16}O reaction, which provides a path from the CN cycle tomore » the CNO bi-cycle and CNO tri-cycle. The measured astrophysical factor for this reaction is dominated by resonant capture through two strong J{sup {pi}}=1{sup -} resonances at E{sub R}=312 and 962 keV and direct capture to the ground state. Recently, a new measurement of the astrophysical factor for the {sup 15}N(p,{gamma}){sup 16}O reaction has been published [P. J. LeBlanc et al., Phys. Rev. C 82, 055804 (2010)]. The analysis has been done using the R-matrix approach with unconstrained variation of all parameters including the asymptotic normalization coefficient (ANC). The best fit has been obtained for the square of the ANC C{sup 2}=539.2 fm{sup -1}, which exceeds the previously measured value by a factor of {approx_equal}3. Here we present a new R-matrix analysis of the Notre Dame-LUNA data with the fixed within the experimental uncertainties square of the ANC C{sup 2}=200.34 fm{sup -1}. Rather than varying the ANC we add the contribution from a background resonance that effectively takes into account contributions from higher levels. Altogether we present ten fits, seven unconstrained and three constrained. For the unconstrained fit with the boundary condition B{sub c}=S{sub c}(E{sub 2}), where E{sub 2} is the energy of the second level, we get S(0)=39.0{+-}1.1 keVb and normalized {chi}-tilde{sup 2}=1.84, i.e., the result

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16 Other...

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16 Other...

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16 Other...

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16 Other...

Quantum chemical investigations on the molecular structure, FTIR, UV-Vis and HOMO-LUMO analysis of 15-16-epoxy-7b, 9a dihydroxylabdane 13(16), 14-dien-6-one

NASA Astrophysics Data System (ADS)

Uppal, Anshul; Pathania, Kamni; Khajuria, Yugal

2018-05-01

The structural, spectroscopic (Fourier Transform Infrared (FT-IR), Ultra-Violet Visible (UV-VIS)) and thermodynamic properties of 15, 16-epoxy-7b, 9a dihydroxylabdane-13(16), 14-dien-6-one were studied by using both experimental techniques and theoretical methods. The FTIR spectrum of the title compound was recorded in the spectral range 4000-400 cm-1. The UV-VIS spectrum was measured in the spectral range 190-800 nm. The quantum chemistry calculations have been performed to compute optimized geometry, molecular parameters, vibrational frequencies along with intensities using Hartree Fock (HF) theory and Density Functional Theory (DFT) with 6-31G basis set. The calculated HOMO-LUMO energies show that the charge transfer occurs within the molecule. The temperature dependence of the thermodynamic properties like heat capacity, entropy and enthalpy of the optimized structure were obtained. Finally, a comparison between the experimental data and the calculated results presented a good agreement.

Floods of September 15-16, 1992, in the Thompson, Weldon, and Chariton River basins, south-central Iowa

USGS Publications Warehouse

Eash, D.A.; Koppensteiner, B.A.

1997-01-01

Water-surface-elevation profiles and peak discharges for the floods of September 15-16, 1992, in the Thompson, Weldon, and Chariton River Basins, south-central Iowa, are presented in this report. The profiles illustrate the 1992 floods along the Thompson, Weldon, Chariton, and South Fork Chariton Rivers and along Elk Creek in the south-central Iowa counties of Adair, Clarke, Decatur, Lucas, Madison, Ringgold, Union, and Wayne. Water-surface-elevation profiles for the floods of July 4, 1981, along the Chariton River in Lucas County and along the South Fork Chariton River in Wayne County also are included in the report for comparative purposes. The September 15-16, 1992, floods are the largest known peak discharges at gaging stations Thompson River at Davis City (station number 06898000) 57,000 cubic feet per second, Weldon River near Leon (station number 06898400) 76,200 cubic feet per second, Chariton River near Chariton (station number 06903400) 37,700 cubic feet per second, and South Fork Chariton River near Promise City (station number 06903700) 70,600 cubic feet per second. The peak discharges were, respectively, 1.7, 2.6, 1.4, and 2.1 times larger than calculated 100-year recurrence-interval discharges. The report provides information on flood stages and discharges and floodflow frequencies for streamflow-gaging stations in the Thompson, Weldon, and Chariton River Basins using flood information collected through 1995. Information on temporary bench marks and reference points established in the Thompson and Weldon River Basins during 1994-95, and in the Chariton River Basin during 1983-84 and 1994-95, also is included in the report. A flood history summarizes rainfall conditions and damages for floods that occurred during 1947, 1959, 1981, 1992, and 1993.

7 CFR 3402.16 - Appendix.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Appendix. 3402.16 Section 3402.16 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE...

Young People's Participation in Extracurricular Physical Education: A Study of 15-16 Year Olds in North-West England and North-East Wales

ERIC Educational Resources Information Center

Smith, Andy; Thurston, Miranda; Green, Ken; Lamb, Kevin

2007-01-01

This paper examines the levels and forms of participation in extracurricular physical education (PE) of a cohort of 1010 15-16 year olds attending seven state schools in north-west England and north-east Wales. The data reveal that extracurricular PE provision in all schools retained a particular focus on competitive team sports alongside a number…

7 CFR 3402.16 - Appendix.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Appendix. 3402.16 Section 3402.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an...

7 CFR 3402.16 - Appendix.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Appendix. 3402.16 Section 3402.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of an...

15 CFR 16.6 - Establishment of fees and charges.

Code of Federal Regulations, 2011 CFR

2011-01-01

... & Technology, as authorized under section 12 of the Act of March 3, 1901, as amended (15 U.S.C. 278b), for this... informational and guidance purposes only in order that the public may evaluate the proposed Specification in...

THE RELATIONSHIP BETWEEN MOTOR COMPETENCE AND PHYSICAL FITNESS IS WEAKER IN THE 15-16 YR. ADOLESCENT AGE GROUP THAN IN YOUNGER AGE GROUPS (4-5 YR. AND 11-12 YR.).

PubMed

Haga, Monika; Gísladóttír, Thórdís; Sigmundsson, Hermundur

2015-12-01

Developing motor competence and physical fitness can affect the maintenance of a sufficient level of physical activity in children and adolescents. This study assesses the relationship between motor competence and physical fitness from childhood through early adolescence. A cross-sectional sample of 194 participants from 4 to 16 years old were divided into three groups; 4-6 yr. (n=42, M age=5.2, SD 0.6), 11-12 yr. (n=58, M age=12.4, SD=0.3), and 15-16 yr. (n=94, M age=15.9, SD=0.4). To assess motor competence, each child completed the Movement Assessment Battery for Children (MABC). To measure physical fitness, three tasks (strength, speed, and endurance) were selected from the Test of Physical Fitness (TPF). To analyze the significance of the difference between the correlation coefficient in the three age groups (samples) (4-6, 11-12, and 15-16 yr.), Fischer r-to-z transformation was used. The correlation (Pearson's) between motor competence and physical fitness in the age groups was statistically higher for the youngest age groups (4-6 and 11-12 yr.) and the adolescent group (age 15-16). The differences between the two youngest age groups were not statistically significant. The results demonstrate that the correlation between motor competence and physical fitness decreases with age.

16 CFR § 1115.15 - Confidentiality and disclosure of data.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Confidentiality and disclosure of data. Â... Confidentiality and disclosure of data. (a) General. The Commission does not routinely make reports available to... information is entitled to exemption from public disclosure under the provisions of the Freedom of Information...

A shock surface geometry - The February 15-16, 1967, event. [solar flare associated interplanetary shock

NASA Technical Reports Server (NTRS)

Lepping, R. P.; Chao, J. K.

1976-01-01

An estimated shape is presented for the surface of the flare-associated interplanetary shock of February 15-16, 1967, as seen in the ecliptic-plane cross section. The estimate is based on observations by Explorer 33 and Pioneers 6 and 7. The estimated shock normal at the Explorer 33 position is obtained by a least-squares shock parameter-fitting procedure for that satellite's data; the shock normal at the Pioneer 7 position is found by using the magnetic coplanarity theorem and magnetic-field data. The average shock speed from the sun to each spacecraft is determined along with the local speed at Explorer 33 and the relations between these speeds and the position of the initiating solar flare. The Explorer 33 shock normal is found to be severely inclined and not typical of interplanetary shocks. It is shown that the curvature of the shock surface in the ecliptic plane near the earth-Pioneer 7 region is consistent with a radius of not more than 0.4 AU.

Young People's Participation in National Curriculum Physical Education: A Study of 15-16 Year Olds in North-West England and North-East Wales

ERIC Educational Resources Information Center

Smith, Andy; Thurston, Miranda; Lamb, Kevin; Green, Ken

2007-01-01

Drawing on data from a broader study which investigated the place of sport and physical activity in the lives of 15-16 year olds in England and Wales, this paper examines a relatively neglected dimension of research in physical education, namely, young people's participation in sport and physical activity through National Curriculum Physical…

Stress analysis of Tellus Regio, Venus, based on gravity and topography - Comparison with Venera 15/16 radar images

NASA Technical Reports Server (NTRS)

Williams, David R.; Gaddis, Lisa

1991-01-01

The tectonics of the Tellus Region highland on Venus is examined using the altimetry and gravity data collected by Pioneer Venus, which were incorporated into a thin elastic shell model to calculate both the global (long-wavelength) and the regional (short-wavelength) stresses for various assumed values of crust, lithosphere, and mantle thickness and modes of compensation. The resultant stress fields were compared to the surface morphology observed in the Venera 15/16 radar images and interpreted in terms of stress history of Tellus Regio. The best fitting parameters were found to be consistent with minor amounts of lithospheric flexure being necessary to produce the observed surface features of this region.

Ice lubrication for moving heavy stones to the Forbidden City in 15th- and 16th-century China

PubMed Central

Li, Jiang; Chen, Haosheng; Stone, Howard A.

2013-01-01

Lubrication plays a crucial role in reducing friction for transporting heavy objects, from moving a 60-ton statue in ancient Egypt to relocating a 15,000-ton building in modern society. Although in China spoked wheels appeared ca. 1500 B.C., in the 15th and 16th centuries sliding sledges were still used in transporting huge stones to the Forbidden City in Beijing. We show that an ice lubrication technique of water-lubricated wood-on-ice sliding was used instead of the common ancient approaches, such as wood-on-wood sliding or the use of log rollers. The technique took full advantage of the natural properties of ice, such as sufficient hardness, flatness, and low friction with a water film. This ice-assisted movement is more efficient for such heavy-load and low-speed transportation necessary for the stones of the Forbidden City. The transportation of the huge stones provides an early example of ice lubrication and complements current studies of the high-speed regime relevant to competitive ice sports. PMID:24191029

Analysis and Comparison of the Temperature and Snowfall Conditions for the Winters of 2014/15 and 2015/16 at Three Ski Resorts in British Columbia, Canada

NASA Astrophysics Data System (ADS)

Pidwirny, M. J.; Pedersen, S.

2016-12-01

Most ski resorts located close to the west coast of Canada experienced extremely poor weather conditions during the winter of 2014/15. During this year, a persistent area of high pressure created "the Blob" in the North Pacific Ocean, which influenced weather patterns on the west coast of North America producing very mild temperatures inland. Further, for many ski resorts winter precipitation that normally arrives in the form of snow, instead fell as rain on many occasions. In Western Canada, ski resorts saw an 18% decrease in skier visits in 2014/15 relative to the average of the previous 8 years. NOAA forecasts for the winter of 2015/16 suggested another mild winter because of a strong El Nino event. Despite this forecast, ski resorts in Western Canada experienced a very good ski season. This research examines the climate characteristics of the winters of 2014/15 and 2015/16 in detail for three ski resorts in British Columbia, Canada: Whistler-Blackcomb, Cypress Mountain, and Big White. The climatic characteristics of these 2 years were also compared to the winter of 2012/13, the most recent banner ski year in the last decade. Data for this study came from Snow-Forecast.com, a web-based company that creates tailor-made weather forecasts for ski resorts around the world using climate model output from NOAA. From Snow-Forecast.com, we mined archived hindcast data that was available at the daily level to analyze and compare mean air temperature and snowfall patterns from November 1 to March 31. Daily temperature data was plotted in a line graph for each year. To better clarify trends, we also graphed an 11-year running mean for the temperature data. Snowfall data was plotted in a cumulative line graph. The winter of 2014/15 was on average warmer by 3.9°C for Cypress, 5.4°C for Whistler, and 4.4°C for Big White than the winter of 2012/13. The winter of 2015/16 was on average 2.5°C, 3.6°C, and 3.6°C warmer than the winter of 2012/13, respectively. Snowfall

13 CFR 117.16 - Hearings.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Hearings. 117.16 Section 117.16... Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 117.15... Hearings and Appeals (OHA) that the matter be scheduled for hearing; or (2) Advise the applicant or...

13 CFR 117.16 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Hearings. 117.16 Section 117.16... Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing is required by § 117.15... Hearings and Appeals (OHA) that the matter be scheduled for hearing; or (2) Advise the applicant or...

50 CFR 16.15 - Importation of live reptiles or their eggs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... under the terms and conditions set forth in § 16.22: (1) Boiga irregularis (brown tree snake). (2... State wildlife conservation agency having jurisdiction over the area of release or by persons having...

50 CFR 16.15 - Importation of live reptiles or their eggs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... under the terms and conditions set forth in § 16.22: (1) Boiga irregularis (brown tree snake). (2... State wildlife conservation agency having jurisdiction over the area of release or by persons having...

50 CFR 16.15 - Importation of live reptiles or their eggs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... under the terms and conditions set forth in § 16.22: (1) Boiga irregularis (brown tree snake). (2... State wildlife conservation agency having jurisdiction over the area of release or by persons having...

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM...

The Usual Suspects: Alcohol, Tobacco and Other Drug Use in 15-To 16-Year-Old School Pupils--Prevalence, Feelings and Perceived Health Risks

ERIC Educational Resources Information Center

Roy, Alastair: Wibberley, Christopher; Lamb, Jon

2005-01-01

This paper presents the findings of a five-year study of year-11 pupils (15?16 years old), based on a sample drawn from seven schools in the North West of England. It examines: use, feelings about close friend's use and perceptions of the health-related risks of specific drugs. The findings conform with those examining other similar populations,…

16 CFR 16.16 - Compensation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Compensation. 16.16 Section 16.16 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.16 Compensation. (a) Committee members. Unless otherwise provided by law, the Commission...

Implications of new measurements of O-16 + p + C-12,13, N-14,15 for the abundances of C, N isotopes at the cosmic ray source

NASA Technical Reports Server (NTRS)

Guzik, T. G.; Wefel, J. P.; Crawford, H. J.; Greiner, D. E.; Lindstrom, P. J.; Schimmerling, W.; Symons, T. J. M.

1985-01-01

The fragmentation of a 225 MeV/n O-16 beam was investigated at the Bevalac. Preliminary cross sections for mass = 13, 14, 15 fragments are used to constrain the nuclear excitation functions employed in galactic propagation calculations. Comparison to cosmic ray isotonic data at low energies shows that in the cosmic ray source C-13/C approximately 2% and N-14/0=3-6%. No source abundance of N-15 is required with the current experimental results.

7 CFR 3401.16 - Proposal review.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SERVICE, DEPARTMENT OF AGRICULTURE RANGELAND RESEARCH GRANTS PROGRAM Scientific Peer Review of Research... comments and in-depth discussions will be provided by peer review group members prior to recommending... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review. 3401.16 Section 3401.16 Agriculture...

Cross sections for production of the 15.10 MeV and other astrophysically significant gamma-ray lines through excitation and spallation of sup 12 C and sup 16 O with protons

NASA Technical Reports Server (NTRS)

Lang, F. L.; Werntz, C. W.; Crannell, C. J.; Trombka, J. I.; Chang, C. C.

1986-01-01

The ratio of the flux of 15.10-MeV gamma rays to the flux of 4.438-MeV gamma rays resulting from excitation of the corresponding states in C-12 as a sensitive measure of the spectrum of the exciting particles produced in solar flares and other cosmic sources. These gamma rays are produced predominantly by interactions with C-12 and O-16, both of which are relatively abundant in the solar photosphere. Gamma ray production cross sections for proton interactions have been reported previously for all important channels except for the production of 15.10-MeV gamma rays from O-16. The first reported measurement of the 15.10-MeV gamma ray production cross section from p + O-16 is presented here. The University of Maryland cyclotron was employed to produce 40-, 65-, and 86-MeV protons which interacted with CH2 and BeO targets. The resultant gamma ray spectra were measured with a high-purity germanium semiconductor detector at 70, 90, 110, 125, and 140 degrees relative to the direction of the incident beam for each proton energy. Other gamma ray lines resulting from direct excitation and spallation reactions with C-12 and 0-16 were observed as well, and their gamma ray production cross sections described.

Simultaneous estimation of 16α-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study.

PubMed

Bhatta, R S; Kumar, Devendra; Chhonker, Y S; Kumar, Deepak; Singh, Suriya P; Sashidhara, Koneni V; Jain, G K

2012-05-01

A selective and sensitive LC-MS-MS method was developed and validated for simultaneous estimation and pharmacokinetic studies of 16α-hydroxycleroda-3,13(14) Z-dien-15,16-olide (K-09) obtained from Polyalthia longifolia and its metabolite (K-9T), a novel antidyslipidemic agent. Sample clean-up involved liquid-liquid extraction of both the analytes and internal standard (rosuvastatin) from 200 μL of hamster plasma. The analytes were chromatographically separated on a Symmetry-Shield C₁₈ (5 µm, 4.6 × 150 mm) column, using acetonitrile-0.1% aqueous formic acid (92:08, v/v) as the mobile phase. Detection was performed using negative ion electrospray ionization in multiple reaction monitoring mode. The MS/MS response was linear over the concentration range 1.56-200 ng/mL, with a correlation coefficient (r²) of 0.998 or better. The within- and between-batch precisions (relative standard deviation, %RSD) and the accuracy (percentage bias) were within acceptable limits as per FDA guidelines. The validated method was successfully applied to reveal the pharmacokinetic parameters of K-09 and metabolite after oral administration. This method will therefore be highly useful for future studies of K-09 and metabolite K-9T pharmacokinetics in preclinical and clinical studies. Copyright © 2011 John Wiley & Sons, Ltd.

Lunar particle shadows and boundary layer experiment: Plasma and energetic particles on the Apollo 15 and 16 subsatellites

NASA Technical Reports Server (NTRS)

Anderson, K. A.; Chase, L. M.; Lin, R. P.; Mccoy, J. E.; Mcguire, R. E.

1974-01-01

The lunar particle shadows and boundary layer experiments aboard the Apollo 15 and 16 subsatellites and scientific reduction and analysis of the data to date are discussed with emphasis on four major topics: solar particles; interplanetry particle phenomena; lunar interactions; and topology and dynamics of the magnetosphere at lunar orbit. The studies of solar and interplanetary particles concentrated on the low energy region which was essentially unexplored, and the studies of lunar interaction pointed up the transition from single particle to plasma characteristics. The analysis concentrated on the electron angular distributions as highly sensitive indicators of localized magnetization of the lunar surface. Magnetosphere experiments provided the first electric field measurements in the distant magnetotail, as well as comprehensive low energy particle measurements at lunar distance.

Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo.

PubMed

Vincent, B; Dive, V; Yiotakis, A; Smadja, C; Maldonado, R; Vincent, J P; Checler, F

1995-07-01

1. We have examined several phosphorus-containing peptides as potential mixed inhibitors of two neurotensin-degrading zinc metallopeptidases, endopeptidase 3.4.24.15 and endopeptidase 3.4.24.16. 2. Among a series of 13 phosphonamide peptides, N-(2-(2-naphtyl)ethylphosphonyl-glycyl-prolyl-norleucine (phosphodiepryl 08) was found to inhibit potently the hydrolysis of neurotensin by purified endopeptidase 3.4.24.15 and 3.4.24.16 with an identical Ki value of 0.4 nM. 3. Phosphodiepryl 08 displayed a strong selectivity towards the two peptidases since it failed to inhibit several other zinc-containing peptidases such as endopeptidase 3.4.24.11, angiotensin-converting enzyme, aminopeptidase M, leucine aminopeptidase and carboxypeptidases A and B. 4. The protective effect of phosphodiepryl 08 on neurotensin degradation was examined in vitro and in vivo in central and peripheral bioassays. 5. Phosphodiepryl 08 virtually abolished neurotensin degradation by 4-day-old plated pure cultured neurones from mouse embryos and greatly potentiated neurotensin-induced antinociception in the mouse hot plate test. 6. In the periphery, phosphodiepryl 08 inhibited neurotensin degradation by membranes prepared from isolated longitudinal smooth muscle of guinea-pig ileum and greatly potentiated the neurotensin-induced contraction of the same longitudinal smooth muscle preparation. 7. Our study indicates that phosphodiepryl 08 behaves as a potent and selective mixed inhibitor of endopeptidase 3.4.24.15 and 3.4.24.16 and can be used as a powerful agent to prevent neurotensin degradation, in vitro and in vivo, in central and peripheral assays.

Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo.

PubMed Central

Vincent, B.; Dive, V.; Yiotakis, A.; Smadja, C.; Maldonado, R.; Vincent, J. P.; Checler, F.

1995-01-01

1. We have examined several phosphorus-containing peptides as potential mixed inhibitors of two neurotensin-degrading zinc metallopeptidases, endopeptidase 3.4.24.15 and endopeptidase 3.4.24.16. 2. Among a series of 13 phosphonamide peptides, N-(2-(2-naphtyl)ethylphosphonyl-glycyl-prolyl-norleucine (phosphodiepryl 08) was found to inhibit potently the hydrolysis of neurotensin by purified endopeptidase 3.4.24.15 and 3.4.24.16 with an identical Ki value of 0.4 nM. 3. Phosphodiepryl 08 displayed a strong selectivity towards the two peptidases since it failed to inhibit several other zinc-containing peptidases such as endopeptidase 3.4.24.11, angiotensin-converting enzyme, aminopeptidase M, leucine aminopeptidase and carboxypeptidases A and B. 4. The protective effect of phosphodiepryl 08 on neurotensin degradation was examined in vitro and in vivo in central and peripheral bioassays. 5. Phosphodiepryl 08 virtually abolished neurotensin degradation by 4-day-old plated pure cultured neurones from mouse embryos and greatly potentiated neurotensin-induced antinociception in the mouse hot plate test. 6. In the periphery, phosphodiepryl 08 inhibited neurotensin degradation by membranes prepared from isolated longitudinal smooth muscle of guinea-pig ileum and greatly potentiated the neurotensin-induced contraction of the same longitudinal smooth muscle preparation. 7. Our study indicates that phosphodiepryl 08 behaves as a potent and selective mixed inhibitor of endopeptidase 3.4.24.15 and 3.4.24.16 and can be used as a powerful agent to prevent neurotensin degradation, in vitro and in vivo, in central and peripheral assays. PMID:7582503

40 CFR 68.15 - Management.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 16 2013-07-01 2013-07-01 false Management. 68.15 Section 68.15... ACCIDENT PREVENTION PROVISIONS General § 68.15 Management. (a) The owner or operator of a stationary source with processes subject to Program 2 or Program 3 shall develop a management system to oversee the...

40 CFR 68.15 - Management.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 16 2014-07-01 2014-07-01 false Management. 68.15 Section 68.15... ACCIDENT PREVENTION PROVISIONS General § 68.15 Management. (a) The owner or operator of a stationary source with processes subject to Program 2 or Program 3 shall develop a management system to oversee the...

40 CFR 68.15 - Management.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 16 2012-07-01 2012-07-01 false Management. 68.15 Section 68.15... ACCIDENT PREVENTION PROVISIONS General § 68.15 Management. (a) The owner or operator of a stationary source with processes subject to Program 2 or Program 3 shall develop a management system to oversee the...

Use of fake identification to purchase alcohol amongst 15-16 year olds: a cross-sectional survey examining alcohol access, consumption and harm.

PubMed

Morleo, Michela; Cook, Penny A; Bellis, Mark A; Smallthwaite, Linda

2010-06-22

Despite legislation and enforcement activities to prevent underage access to alcohol, underage individuals continue to be able to access alcohol and to do so at levels which put them at significant risk of alcohol-related harm. An opportunistic survey of 15-16 year olds (n = 9,833) across North West England was used to examine alcohol consumption, methods of access and related harms experienced (such as regretted sex). Associations between these were analysed using chi square and logistic regression techniques. Over a quarter (28.3%) of 15-16 year old participants who drank reported having bought their own alcohol. One seventh (14.9%) of these owned at least one form of fake identification for which by far the most common purchase method was online. Logistic regression analyses showed that those who owned fake identification were significantly more likely to be male (AOR = 2.0; 95% CI = 1.7-2.5; P < 0.001) and to receive a higher personal weekly income (comparing those who received > pound30 with those who received < or = pound10: AOR = 3.7; 95% CI = 2.9-4.9; P < 0.001). After taking into account differences in demographic characteristics and personal weekly income, ownership of fake identification was significantly associated with binge drinking (AOR = 3.5, 95% CI = 2.8-4.3; P < 0.001), frequent drinking (AOR = 3.0, 95% CI = 2.5-3.7; P < 0.001) and public drinking (AOR = 3.3, 95% CI = 2.5-4.1; P < 0.001) compared with those who did not own fake identification. Further, those who reported owning fake identification were significantly more likely to report experiencing a variety of alcohol-related harms such as regretted sex after drinking (chi square, all P < 0.001). Young people (aged 15-16 years) who have access to fake identification are at a particularly high risk of reporting hazardous alcohol consumption patterns and related harm. Owning fake identification should be considered a risk factor for involvement in risky drinking behaviours. Information on these

Electron density of Rhizophora spp. wood using Compton scattering technique at 15.77, 17.48 and 22.16 keV XRF energies

NASA Astrophysics Data System (ADS)

Shakhreet, B. Z.; Bauk, S.; Shukri, A.

2015-02-01

Compton (incoherently) scattered photons which are directly proportional to the electron density of the scatterer, have been employed in characterizing Rhizophora spp. as breast tissue equivalent. X-ray fluorescent scattered incoherently from Rhizophora spp. sample was measured using Si-PIN detector and three XRF energy values 15.77, 17.48 and 22.16 keV. This study is aimed at providing electron density information in support of the introduction of new tissue substitute materials for mammography phantoms.

16 CFR § 1203.15 - Positional stability test (roll-off resistance).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Positional stability test (roll-off... stability test (roll-off resistance). (a) Test equipment. (1) Headforms. The test headforms shall comply with the dimensions of the full chin ISO reference headforms sizes A, E, J, M, and O. (2) Test fixture...

An Analysis of Type IV Precision Measurement Equipment Laboratory Logistical Support Relative to the Implementation of F-15/F-16 Two-Level Maintenance

DTIC Science & Technology

1994-09-01

wife, Margie, for her patience and understanding. Graduate school definitely affects the family . Margie allowed me to use many valuable family hours...Consolidations and reorganizations, in which the face of logistics is changing day -by- day , are taking place throughout the Department of Defense. Two...will focus on Type IV F-15 and Type IV F-16 PMELs. Imporane of Research The two-level maintenance concept significantly alters the structure of

16 CFR 1105.13 - Noncompensable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... accounting principles and practices or part 1-15, Federal Procurement Regulations (41 CFR part 1-15). ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Noncompensable costs. 1105.13 Section 1105... CONTRIBUTIONS TO COSTS OF PARTICIPANTS IN DEVELOPMENT OF CONSUMER PRODUCT SAFETY STANDARDS § 1105.13...

7 CFR 2903.16 - Organizational management information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Organizational management information. 2903.16... § 2903.16 Organizational management information. Specific management information relating to an applicant... a grant identified under this program, if such information has not been provided previously. Copies...

7 CFR 3431.16 - Certifications and verifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Certifications and verifications. 3431.16 Section 3431.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE VETERINARY MEDICINE LOAN REPAYMENT PROGRAM Administration of the Veterinary Medicine...

7 CFR 3431.16 - Certifications and verifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Certifications and verifications. 3431.16 Section 3431.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE VETERINARY MEDICINE LOAN REPAYMENT PROGRAM Administration of the Veterinary Medicine...

7 CFR 3431.16 - Certifications and verifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Certifications and verifications. 3431.16 Section 3431.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE VETERINARY MEDICINE LOAN REPAYMENT PROGRAM Administration of the Veterinary Medicine...

7 CFR 2903.16 - Organizational management information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Organizational management information. 2903.16 Section 2903.16 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration...

7 CFR 2903.16 - Organizational management information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Organizational management information. 2903.16 Section 2903.16 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration...

7 CFR 2903.16 - Organizational management information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Organizational management information. 2903.16 Section 2903.16 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration...

7 CFR 2903.16 - Organizational management information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Organizational management information. 2903.16 Section 2903.16 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM Award Administration...

Human papillomavirus 16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy Korean women.

PubMed

Kim, Seung Cheol; Song, Yong Sang; Kim, Young-Tae; Kim, Young Tak; Ryu, Ki-Sung; Gunapalaiah, Bhavyashree; Bi, Dan; Bock, Hans L; Park, Jong-Sup

2011-06-30

The study assessed the immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Korean women aged 15-25 years. Phase IIIB, double-blind, randomised (2:1), multi-centre trial was conducted in Korea from June 2007 to March 2008. The study enrolled 225 women in the HPV (N=149) and placebo (N=76) groups who received three doses of HPV-16/18 AS04-adjuvanted vaccine or placebo (aluminium hydroxide) administered intramuscularly at 0, 1, and 6 months and were followed until one month post-dose 3. Serum samples were collected pre-vaccination and one month post-dose 3. Safety and reactogenicity data were collected throughout. In this trial, 208 women completed the study (141 in HPV group; 67 in placebo group). At month 7, all initially seronegative women had seroconverted for HPV-16 and HPV-18 antibodies with anti-HPV-16 and anti-HPV-18 geometric mean titres of 9,351.4 El.U/mL (95% CI, 8,145.5 to 10,735.8) and 4204.1 El.U/mL (95% CI, 3,626.5 to 4,873.6), respectively. Initially seropositive women showed similar increase in geometric mean titre levels. Compliance to the three dose vaccination course was 95.3% in HPV and 89.5% in placebo group. Solicited local (pain) and general (fatigue, myalgia or headache) symptoms were commonly reported in both groups. Three serious adverse events were reported (two in HPV group; one in placebo group), all unrelated to vaccination by the investigator; all recovered. The HPV-16/18 AS04-adjuvanted vaccine was highly immunogenic with a clinically acceptable safety profile in Korean women. This study was in line with previous global studies in Europe, North America, and Brazil. (ClinicalTrials.gov number, NCT 00485732.).

18 CFR 16.14 - Departmental recommendation for takeover.

Code of Federal Regulations, 2011 CFR

2011-04-01

... recommendation for takeover. 16.14 Section 16.14 Conservation of Power and Water Resources FEDERAL ENERGY... 15 of the Federal Power Act § 16.14 Departmental recommendation for takeover. (a) A Federal department or agency may file a recommendation that the United States exercise its right to take over a...

18 CFR 16.14 - Departmental recommendation for takeover.

Code of Federal Regulations, 2010 CFR

2010-04-01

... recommendation for takeover. 16.14 Section 16.14 Conservation of Power and Water Resources FEDERAL ENERGY... 15 of the Federal Power Act § 16.14 Departmental recommendation for takeover. (a) A Federal department or agency may file a recommendation that the United States exercise its right to take over a...

Fuel gas production from animal and agricultural residues and biomass. Quarterly coordination meeting, March 15-16, 1979, Tampa, Florida. Third quarterly progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, D L; Ashare, E; Wentworth, R L

1979-04-24

The eleventh quarterly coordination meeting of the methane production group of the Fuels From Biomass Systems Branch, US Department of Energy was held at Tampa, Florida, March 15-16, 1979. Progress reports were presented by the contractors and a site visit was made to Kaplan Industries, Bartow, Florida to see the Hamilton Standard demonstration facility for digestion of environmental feedlot residue to methane. A meeting agenda, a list of attendees, and progress reports are presented.

Whitson working on the Nutrition Experiment during Expedition 15/Expedition 16

NASA Image and Video Library

2007-10-19

ISS015-E-35308 (19 Oct. 2007) --- NASA astronaut Peggy A. Whitson, Expedition 16 commander, works with the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) in the Destiny laboratory of the International Space Station. MELFI is a low temperature freezer facility with nominal operating temperatures of -80, -26 and +4 degrees Celsius that will preserve experiment materials over long periods.

29 CFR 1626.15 - Commission enforcement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Commission enforcement. 1626.15 Section 1626.15 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.15 Commission enforcement. (a) As provided in sections 9, 11, 16 and 17...

29 CFR 1626.15 - Commission enforcement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Commission enforcement. 1626.15 Section 1626.15 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.15 Commission enforcement. (a) As provided in sections 9, 11, 16 and 17...

29 CFR 1626.15 - Commission enforcement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Commission enforcement. 1626.15 Section 1626.15 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.15 Commission enforcement. (a) As provided in sections 9, 11, 16 and 17...

29 CFR 1626.15 - Commission enforcement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Commission enforcement. 1626.15 Section 1626.15 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.15 Commission enforcement. (a) As provided in sections 9, 11, 16 and 17...

Magnetic studies on Apollo 15 and 16 lunar samples

NASA Technical Reports Server (NTRS)

Pearce, G. W.; Gose, W. A.; Strangway, D. W.

1973-01-01

The magnetic properties of lunar samples are almost exclusively due to rather pure metallic iron. The mare basalt contains about 0.06 wt.% Fe, the soils 0.5-0.6 wt.%, and the breccias 0.3-1.0 wt.%. Most of the additional iron in the soils and breccias is believed to be the result of reduction processes operating on the lunar surface. Whereas the total metallic iron content of the soils from all landing sites is rather constant, the Fe(0)/Fe(++) ratio and the average iron grain size increase with the age of the landing site, reflecting increasing maturity. The crystalline rocks studied from Apollo 16 have highly variable, but generally, very high metallic Fe content (up to 1.7 wt.% Fe). It is suggested that these rocks are either breccias or igneous samples which have been severely thermally metamorphosed in a highly reducing environment.

Effect of simulated in-flight thrust reversing on vertical-tail loads of F-18 and F-15 airplane models. [conducted in the Langley 16-foot transonic tunnel

NASA Technical Reports Server (NTRS)

Bare, E. A.; Berrier, B. L.; Capone, F. J.

1981-01-01

Investigations were conducted in the Langley 16-Foot Transonic Tunnel to provide data on a 0.10-scale model of the prototype F-18 airplane and a 0.047-scale model of the F-15 three-surface configuration (canard, wing, and horizontal tails). Test data were obtained at static conditions and at Mach numbers from 0.6 to 1.2 over an angle-of-attack range from 2 deg to 15 deg. Nozzle pressure ratio was varied from jet off to about 8.0.

7 CFR 3405.16 - Access to peer review information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Access to peer review information. 3405.16 Section 3405.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.16 Access...

7 CFR 3405.16 - Access to peer review information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Access to peer review information. 3405.16 Section 3405.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.16 Access...

7 CFR 3405.16 - Access to peer review information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Access to peer review information. 3405.16 Section 3405.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.16 Access...

7 CFR 3405.16 - Access to peer review information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Access to peer review information. 3405.16 Section 3405.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM Supplementary Information § 3405.16 Access...

14 CFR 35.16 - Propeller critical parts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Propeller critical parts. 35.16 Section 35... AIRWORTHINESS STANDARDS: PROPELLERS Design and Construction § 35.16 Propeller critical parts. The integrity of each propeller critical part identified by the safety analysis required by § 35.15 must be established...

Characterization of the post-translational modification of recombinant human BMP-15 mature protein

PubMed Central

Saito, Seiji; Yano, Keiichi; Sharma, Shweta; McMahon, Heather E.; Shimasaki, Shunichi

2008-01-01

Bone morphogenetic protein-15 (BMP-15) is an oocyte-secreted factor critical for the regulation of ovarian physiology. When recombinant human BMP-15 (rhBMP-15) produced in human embryonic kidney 293 cells was subjected to SDS-PAGE analysis, two mature protein forms corresponding to 16 kDa (P16) and 17 kDa (P17) were observed. Despite the physiological relevance and critical function of BMP-15 in female reproduction, little is known about the structure of rhBMP-15. Here, we have analyzed the structure of the rhBMP-15 mature proteins (P16 and P17) using state-of-the-art proteomics technology. Our findings are as follows: (1) the N-terminal amino acid of P16 and P17 is pyroglutamic acid; (2) the Ser residue at the sixth position of P16 is phosphorylated; (3) P17 is O-glycosylated at Thr10; and (4) the C-terminal amino acid of P16 and P17 is truncated. These findings are the first knowledge of the structure of rhBMP-15 mature protein toward understanding the molecular basis of BMP-15 function and could provide an important contribution to the rapidly progressing research area involving oocyte-specific growth factors in modulation of female fertility. PMID:18227435

7 CFR 3015.16 - Construction and facility improvement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Construction and facility improvement. 3015.16 Section 3015.16 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Bonding and Insurance...

16 CFR 1404.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Definitions. 1404.3 Section 1404.3... INSULATION § 1404.3 Definitions. The definitions in section 3 of the Consumer Product Safety Act (15 U.S.C... as the marketer of the brand). ...

The effect of smoking on periodontal health of 15- to 16-year-old adolescents.

PubMed

Heikkinen, Anna Maria; Pajukanta, Riitta; Pitkäniemi, Janne; Broms, Ulla; Sorsa, Timo; Koskenvuo, Markku; Meurman, Jukka H

2008-11-01

Smoking is a severe risk factor for periodontal health in adults, but data on the effect of smoking on periodontal health in teenage populations are sparse. The aim of this study was to investigate the effect of duration and quantity of smoking on periodontal health in teenagers and possible differences between genders. The oral health of 501 adolescents (15- to 16-year-old boys [n = 258] and girls [n = 243]) was examined. A structured questionnaire about self-reported smoking and health habits was filled out, and bitewing x-rays were taken. Clinical examinations included measuring periodontal indexes, such as visible plaque index, bleeding on probing, root calculus (RC), probing depth, and attachment loss. Results were analyzed by generalized linear logistic regression. Twenty-five percent of boys and 27% of girls were smokers. The boys and girls who smoked had higher RC values than non-smokers (P <0.001). The adjusted scores for smoking boys and girls were 17.3 (95% confidence interval [CI]: 8.6 to 31.7) and 13.6 (95% CI: 5.5 to 29.7), respectively. The adjusted scores for non-smokers were 10.4 (95% CI: 5.7 to 18.3) and 7.7 (95% CI: 3.3 to 17.3), respectively. Smoking boys and girls also had more periodontal pockets > or =4 mm than non-smokers: the score for boys was 4.6 (95% CI: 2.2 to 9.1), and the score for girls was 5.4 (95% CI: 1.1 to 23.2; P <0.001). Smoking significantly impaired periodontal health in teenagers.

16 CFR 1203.13 - Test schedule.

Code of Federal Regulations, 2010 CFR

2010-01-01

... environments, respectively) shall be tested in accordance with the dynamic retention system strength test at... Peripheral vision § 1203.15 Positional stability § 1203.16 Retention system strength § 1203.17 Impact tests...

46 CFR 97.16-1 - Use of auto pilot.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

46 CFR 97.16-1 - Use of auto pilot.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

46 CFR 97.16-1 - Use of auto pilot.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

46 CFR 97.16-1 - Use of auto pilot.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

46 CFR 97.16-1 - Use of auto pilot.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

Detector-level spectral characterization of the Suomi National Polar-orbiting Partnership Visible Infrared Imaging Radiometer Suite long-wave infrared bands M15 and M16.

PubMed

Padula, Francis; Cao, Changyong

2015-06-01

The Suomi National Polar-orbiting Partnership (S-NPP) Visible Infrared Imaging Radiometer Suite (VIIRS) sensor data record (SDR) product achieved validated maturity status in March 2014 after roughly two years of on-orbit characterization (S-NPP spacecraft launched on 28 October 2011). During post-launch analysis the VIIRS Sea Surface Temperature (SST) Environmental Data Record (EDR) team observed an anomalous striping pattern in the daytime SST data. Daytime SST retrievals use the two VIIRS long-wave infrared bands: M15 (10.7 μm) and M16 (11.8 μm). To assess possible root causes due to detector-level spectral response function (SRF) effects, a study was conducted to compare the radiometric response of the detector-level and operational-band averaged SRFs of VIIRS bands M15 and M16. The study used simulated hyperspectral blackbody radiance data and clear-sky ocean hyperspectral radiances under different atmospheric conditions. It was concluded that the SST product is likely impacted by small differences in detector-level SRFs and that if users require optimal radiometric performance, detector-level processing is recommended for both SDR and EDR products. Future work should investigate potential SDR product improvements through detector-level processing in support of the generation of Suomi NPP VIIRS climate quality SDRs.

16 CFR 803.7 - Expiration of notification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... expire 1 year following the expiration of the waiting period. If the acquiring person's holdings do not... notification on January 15 of Year 1 to acquire voting securities of B. On February 15 of Year 1, prior to... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Expiration of notification. 803.7 Section...

16 CFR 803.7 - Expiration of notification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... expire 1 year following the expiration of the waiting period. If the acquiring person's holdings do not... notification on January 15 of Year 1 to acquire voting securities of B. On February 15 of Year 1, prior to... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Expiration of notification. 803.7 Section...

16 CFR 803.7 - Expiration of notification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... expire 1 year following the expiration of the waiting period. If the acquiring person's holdings do not... notification on January 15 of Year 1 to acquire voting securities of B. On February 15 of Year 1, prior to... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Expiration of notification. 803.7 Section...

16 CFR 803.7 - Expiration of notification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... expire 1 year following the expiration of the waiting period. If the acquiring person's holdings do not... notification on January 15 of Year 1 to acquire voting securities of B. On February 15 of Year 1, prior to... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Expiration of notification. 803.7 Section...

Apollo 16 Evolved Lithology Sodic Ferrogabbro

NASA Technical Reports Server (NTRS)

Zeigler, Ryan; Jolliff, B. L.; Korotev, R. L.

2014-01-01

Evolved lunar igneous lithologies, often referred to as the alkali suite, are a minor but important component of the lunar crust. These evolved samples are incompatible-element rich samples, and are, not surprisingly, most common in the Apollo sites in (or near) the incompatible-element rich region of the Moon known as the Procellarum KREEP Terrane (PKT). The most commonly occurring lithologies are granites (A12, A14, A15, A17), monzogabbro (A14, A15), alkali anorthosites (A12, A14), and KREEP basalts (A15, A17). The Feldspathic Highlands Terrane is not entirely devoid of evolved lithologies, and rare clasts of alkali gabbronorite and sodic ferrogabbro (SFG) have been identified in Apollo 16 station 11 breccias 67915 and 67016. Curiously, nearly all pristine evolved lithologies have been found as small clasts or soil particles, exceptions being KREEP basalts 15382/6 and granitic sample 12013 (which is itself a breccia). Here we reexamine the petrography and geochemistry of two SFG-like particles found in a survey of Apollo 16 2-4 mm particles from the Cayley Plains 62283,7-15 and 62243,10-3 (hereafter 7-15 and 10-3 respectively). We will compare these to previously reported SFG samples, including recent analyses on the type specimen of SFG from lunar breccia 67915.

Characterization and evaluation of an oral microemulsion containing the antitumor diterpenoid compound ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid

PubMed Central

Lu, Yingnian; Wu, Kefeng; Li, Li; He, Yuhui; Cui, Liao; Liang, Nianci; Mu, Bozhong

2013-01-01

The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (henceforth referred to as 5F), to enhance its bioavailability and evaluate its hepatotoxicity. Pseudoternary phase diagrams showed that the optimal microemulsion formulation contained 45% water, 10% castor oil as the oil phase, 15% Cremophor EL as the surfactant, and 30% as a cosurfactant mixture of 1,2-propanediol and polyethylene glycol (PEG)-400 (2:1, w/w). The microemulsion preparation was characterized and its droplet diameter was within 50 nm. Release of 5F in vitro from the microemulsion was slightly increased compared with a suspension containing the same amount of active drug. Pharmacokinetic parameters in vivo indicated that bioavailability was markedly improved, with the relative bioavailability being 616.15% higher for the microemulsion than for the suspension. Toxicity tests showed that the microemulsion had no hepatotoxicity in mice. These results suggest the potential for 5F microemulsion to be administered by the oral route. PMID:23690685

Characterization and evaluation of an oral microemulsion containing the antitumor diterpenoid compound ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid.

PubMed

Lu, Yingnian; Wu, Kefeng; Li, Li; He, Yuhui; Cui, Liao; Liang, Nianci; Mu, Bozhong

2013-01-01

The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (henceforth referred to as 5F), to enhance its bioavailability and evaluate its hepatotoxicity. Pseudoternary phase diagrams showed that the optimal microemulsion formulation contained 45% water, 10% castor oil as the oil phase, 15% Cremophor EL as the surfactant, and 30% as a cosurfactant mixture of 1,2-propanediol and polyethylene glycol (PEG)-400 (2:1, w/w). The microemulsion preparation was characterized and its droplet diameter was within 50 nm. Release of 5F in vitro from the microemulsion was slightly increased compared with a suspension containing the same amount of active drug. Pharmacokinetic parameters in vivo indicated that bioavailability was markedly improved, with the relative bioavailability being 616.15% higher for the microemulsion than for the suspension. Toxicity tests showed that the microemulsion had no hepatotoxicity in mice. These results suggest the potential for 5F microemulsion to be administered by the oral route.

48 CFR 16.603-4 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... clause at 52.216-24, Limitation of Government Liability, with dollar amounts completed in a manner...) completed in a manner consistent with 16.603-2(c). If at the time of entering into the letter contract, the... words “and certified cost or pricing data in accordance with FAR 15.408, Table 15-2 supporting its...

48 CFR 16.603-2 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 16.603-2... fee in accordance with subpart 15.4 and part 31, subject to appeal as provided in the Disputes clause...

F-16 Instructional System Design Alternatives.

DTIC Science & Technology

1981-03-01

inservice training 1-15 Subsystem: Supply maintenance Function: FL 4.8 Perform supply maintenance FL...000 0 F-16 AIRCREW TRAINING DEVELOPMENT PROJECT Contract No. F02604-79-C8875 DTIC ELECTE:, .JUNO 8 1981 K2>)F-i6 JSTRUCTIONAL_.YSTEM" P§ __SIGN AL ER TI...8217’’’ ’ " -... . .... . .. ..-- , .. , ... 4:-... <" ’’’’- " - . . . .. -,-: - PREFACE This report was created for the F-16 Aircrew Training De- velopment Project contract

Effect of nozzle and vertical-tail variables on the performance of a 3-surface F-15 model at transonic Mach numbers. [Langley 16 foot transonic tunnel

NASA Technical Reports Server (NTRS)

Pendergraft, O. C., Jr.; Bare, E. A.

1982-01-01

An investigation was conducted in the Langley 16 foot transonic tunnel to determine the longitudinal aerodynamic characteristics of twin two dimensional nozzles and twin baseline axisymmetric nozzles installed on a fully metric 0.047 scale model of the F-15 three surface configuration (canards, wing, horizontal tails). The effects on performance of two dimensional nozzle in flight thrust reversing, locations and orientation of the vertical tails, and deflections of the horizontal tails were also determined. Test data were obtained at static conditions and at Mach numbers from 0.60 to 1.20 over an angle of attack range from -2 deg to 15 deg. Nozzle pressure ratio was varied from jet off to about 6.5.

18 CFR 16.14 - Departmental recommendation for takeover.

Code of Federal Regulations, 2013 CFR

2013-04-01

... hydroelectric power project with a license that is subject to sections 14 and 15 of the Federal Power Act. The... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Departmental recommendation for takeover. 16.14 Section 16.14 Conservation of Power and Water Resources FEDERAL ENERGY...

18 CFR 16.14 - Departmental recommendation for takeover.

Code of Federal Regulations, 2014 CFR

2014-04-01

... hydroelectric power project with a license that is subject to sections 14 and 15 of the Federal Power Act. The... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Departmental recommendation for takeover. 16.14 Section 16.14 Conservation of Power and Water Resources FEDERAL ENERGY...

48 CFR 52.215-16 - Facilities Capital Cost of Money.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable cost...

48 CFR 52.215-16 - Facilities Capital Cost of Money.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable cost...

48 CFR 52.215-16 - Facilities Capital Cost of Money.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable cost...

48 CFR 52.215-16 - Facilities Capital Cost of Money.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable cost...

48 CFR 52.215-16 - Facilities Capital Cost of Money.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable cost...

7 CFR 3405.16 - Access to peer review information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Access to peer review information. 3405.16 Section 3405.16 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS PROGRAM...

Report from enhanced safety surveillance of two influenza vaccines (Vaxigrip and Intanza 15 μg) in two European countries during influenza season 2016/17 and comparison with 2015/16 season

PubMed Central

Chabanon, Anne Laure; Bricout, Hélène; Ballandras, Céline; Souverain, Audrey; Caroe, Timothy David; Butler, Karina M.

2018-01-01

ABSTRACT Passive enhanced safety surveillance (ESS) was implemented in the United Kingdom and in the Republic of Ireland for Vaxigrip and Intanza 15 µg influenza vaccines during the 2016/17 influenza season. Lessons learned during 2015/16 ESS implementation were integrated and applied towards the current ESS. The primary objective was to estimate the reporting rates of suspected adverse reactions (ARs) occurring within 7 days of vaccination with Vaxigrip or Intanza 15 µg. For Vaxigrip (N = 962), 17 vaccinees (1.8%) reported 59 suspected ARs (6.1%) within 7 days of vaccination. For Intanza 15 µg (N = 1000), 21 vaccinees (2.1%) reported 101 (10.1%) suspected ARs within 7 days of vaccination. No obvious pattern in the type of suspected ARs or their frequency was observed for either vaccine. None of the frequencies of suspected ARs were above the 2015/16 ESS frequencies for Vaxigrip, whereas for Intanza 15 µg only one AR (oropharyngeal pain) crossed the historical threshold. There was no change in reactogenicity and data was consistent with the safety profiles of the two vaccines. The passive ESS experience gained from season to season will help to contribute to a sustainable safety surveillance system of seasonal influenza vaccines early in the season. PMID:29148911

Registration of temperate quality protein maize (QPM) lines BQPM9, BQPM10, BQPM11, BQPM12, BQPM13, BQPM14, BQPM15, BQPM16, and BQPM17

USDA-ARS?s Scientific Manuscript database

The discovery of the opaque2 (o2) mutation and o2 modifier genes in maize (Zea mays L.) has resulted in the development of Quality Protein Maize (QPM) lines with higher lysine and tryptophan content. QPM lines BQPM9, BQPM10, BQPM11, BQPM12, BQPM13, BQPM14, BQPM15, BQPM16, and BQPM17 were developed a...

49 CFR 585.16 - Records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Requirements § 585.16 Records. Each manufacturer shall maintain records of the Vehicle Identification Number of each vehicle for which information is reported under § 585.15(c) until December 31, 2011. Each manufacturer shall maintain records of the Vehicle Identification Number of each vehicle for which information...

Randomized Open Trial Comparing 2-Dose Regimens of the Human Papillomavirus 16/18 AS04-Adjuvanted Vaccine in Girls Aged 9-14 Years Versus a 3-Dose Regimen in Women Aged 15-25 Years.

PubMed

Puthanakit, Thanyawee; Huang, Li-Min; Chiu, Cheng-Hsun; Tang, Ren-Bin; Schwarz, Tino F; Esposito, Susanna; Frenette, Louise; Giaquinto, Carlo; McNeil, Shelly; Rheault, Paul; Durando, Paolo; Horn, Michael; Klar, Maximilian; Poncelet, Sylviane; De Simoni, Stéphanie; Friel, Damien; De Muynck, Benoit; Suryakiran, Pemmaraju V; Hezareh, Marjan; Descamps, Dominique; Thomas, Florence; Struyf, Frank

2016-08-15

This randomized, open trial compared regimens including 2 doses (2D) of human papillomavirus (HPV) 16/18 AS04-adjuvanted vaccine in girls aged 9-14 years with one including 3 doses (3D) in women aged 15-25 years. Girls aged 9-14 years were randomized to receive 2D at months 0 and 6 (M0,6; (n = 550) or months 0 and 12 (M0,12; n = 415), and women aged 15-25 years received 3D at months 0, 1, and 6 (n = 482). End points included noninferiority of HPV-16/18 antibodies by enzyme-linked immunosorbent assay for 2D (M0,6) versus 3D (primary), 2D (M0,12) versus 3D, and 2D (M0,6) versus 2D (M0,12); neutralizing antibodies; cell-mediated immunity; reactogenicity; and safety. Limits of noninferiority were predefined as <5% difference in seroconversion rate and <2-fold difference in geometric mean antibody titer ratio. One month after the last dose, both 2D regimens in girls aged 9-14 years were noninferior to 3D in women aged 15-25 years and 2D (M0,12) was noninferior to 2D (M0,6). Geometric mean antibody titer ratios (3D/2D) for HPV-16 and HPV-18 were 1.09 (95% confidence interval, .97-1.22) and 0.85 (.76-.95) for 2D (M0,6) versus 3D and 0.89 (.79-1.01) and 0.75 (.67-.85) for 2D (M0,12) versus 3D. The safety profile was clinically acceptable in all groups. The 2D regimens for the HPV-16/18 AS04-adjuvanted vaccine in girls aged 9-14 years (M0,6 or M0,12) elicited HPV-16/18 immune responses that were noninferior to 3D in women aged 15-25 years. NCT01381575. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

25 CFR 163.15 - Advertisement of sales.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Advertisement of sales. 163.15 Section 163.15 Indians... Management and Operations § 163.15 Advertisement of sales. Except as provided in §§ 163.13, 163.14, 163.16, and 163.26 of this part, sales of forest products shall be made only after advertising. (a) The...

25 CFR 163.15 - Advertisement of sales.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Advertisement of sales. 163.15 Section 163.15 Indians... Management and Operations § 163.15 Advertisement of sales. Except as provided in §§ 163.13, 163.14, 163.16, and 163.26 of this part, sales of forest products shall be made only after advertising. (a) The...

40 CFR 76.15 - Test methods and procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Test methods and procedures. 76.15 Section 76.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) ACID RAIN NITROGEN OXIDES EMISSION REDUCTION PROGRAM § 76.15 Test methods and procedures. (a) The...

40 CFR 76.15 - Test methods and procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Test methods and procedures. 76.15 Section 76.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) ACID RAIN NITROGEN OXIDES EMISSION REDUCTION PROGRAM § 76.15 Test methods and procedures. (a) The...

16 CFR 306.4 - Preemption.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Preemption. 306.4 Section 306.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS AUTOMOTIVE FUEL RATINGS, CERTIFICATION AND POSTING General § 306.4 Preemption. The Petroleum Marketing Practices Act (“PMPA”), 15 U.S.C...

16 CFR 306.4 - Preemption.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Preemption. 306.4 Section 306.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS AUTOMOTIVE FUEL RATINGS, CERTIFICATION AND POSTING General § 306.4 Preemption. The Petroleum Marketing Practices Act (“PMPA”), 15 U.S.C...

16 CFR 306.4 - Preemption.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Preemption. 306.4 Section 306.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS AUTOMOTIVE FUEL RATINGS, CERTIFICATION AND POSTING General § 306.4 Preemption. The Petroleum Marketing Practices Act (“PMPA”), 15 U.S.C...

16 CFR 306.4 - Preemption.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Preemption. 306.4 Section 306.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS AUTOMOTIVE FUEL RATINGS, CERTIFICATION AND POSTING General § 306.4 Preemption. The Petroleum Marketing Practices Act (“PMPA”), 15 U.S.C...

16 CFR 306.4 - Preemption.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Preemption. 306.4 Section 306.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS AUTOMOTIVE FUEL RATINGS, CERTIFICATION AND POSTING General § 306.4 Preemption. The Petroleum Marketing Practices Act (“PMPA”), 15 U.S.C...

The effect of color on the production of responses to Rorschach cards VIII, IX, and X in age groups of 11-12 and 15-16 years.

PubMed

Silva, Danilo R; Ferreira, Ana Sousa

2014-01-01

The effect of color on the production of responses to the Rorschach task has been considered by investigators from 2 different positions: (a) that color has little effect on the production of responses, and (b) that color increases the number of responses. Some previous results found by the current investigators have supported the first position for the last 3 fully colored Rorschach cards (VIII, IX, and X), in children from 5 to 12 years old. Other studies of ours, however, have confirmed the second position for these same cards with a group of young adults 17 to 23 years old. As there was no increase of responses up to age 12, for this study we hypothesized a developmental effect in adolescence such that there would be an increase in the production of responses to the colored Rorschach cards at the age of 15 to 16 years, and this is what the results indicate. From a pragmatic standpoint, these results imply a revision of interpretive meaning for the Color and Affective Ratio variables in children's protocols. Our results also indicate that color cannot be regarded as a means of expression of affect at age 11 to 12 like it will be from age 15 to 16 and on.

Molecular Characterization of Human MUC16 (CA125) in Breast Cancer

DTIC Science & Technology

2015-04-01

and O-linked glycosylation takes place as it progresses through the cis-medial-trans Golgi apparatus . In addition, the juxta-membrane ectodomain...swapping experiment. Further, the cleavage of MUC16 was found to take place in the Golgi /post- Golgi compartments and is dependent on the acidic pH in the...therapeutic interventions based on MUC16. 15. SUBJECT TERMS Mucin 16 (MUC16), MUC16-Cter, Golgi /post- Golgi , nuclear localization 16. SECURITY

45 CFR 671.16 - Designation and redesignation of pollutants

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Designation and redesignation of pollutants 671.16 Section 671.16 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... interested parties, the Environmental Protection Agency and other Federal agencies pursuant to § 671.15, the...

16 CFR 1210.11 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... CIGARETTE LIGHTERS Certification Requirements § 1210.11 General. Section 14(a) of the Consumer Product... certify that their products comply with the Safety Standard for Cigarette Lighters. This subpart B..., recordkeeping, and reporting pursuant to sections 14, 16(b), 17(g), and 27(e) of the CPSA, 15 U.S.C. 2063, 2065...

16 CFR 1210.11 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... CIGARETTE LIGHTERS Certification Requirements § 1210.11 General. Section 14(a) of the Consumer Product... certify that their products comply with the Safety Standard for Cigarette Lighters. This subpart B..., recordkeeping, and reporting pursuant to sections 14, 16(b), 17(g), and 27(e) of the CPSA, 15 U.S.C. 2063, 2065...

Can use of healthcare services among 15-16-year-olds predict an increased level of high school dropout? A longitudinal community study.

PubMed

Homlong, Lisbeth; Rosvold, Elin O; Haavet, Ole R

2013-09-19

To study associations between healthcare seeking in 15-16-year-olds and high school dropout 5 years later. Longitudinal community study. Data from a comprehensive youth health survey conducted in 2000-2004, linked to data from national registries up to 2010. 13 964 10th grade secondary school students in six Norwegian counties. Logistic regression was used to compute ORs for high school dropout. The total proportion of students not completing high school 5 years after registering was 29% (girls 24%, boys 34%). Frequent attenders to school health services and youth health clinics at age 15-16 years had a higher dropout rate (37/48% and 45/71%), compared with those with no or moderate use. Adolescents referred to mental health services were also more likely to drop out (47/62%). Boys with moderate use of a general practitioner (GP) had a lower dropout rate (30%). A multiple logistic regression analysis, in which we adjusted for selected health indicators and sociodemographic background variables, revealed that seeking help from the youth health clinic and consulting mental health services, were associated with increased level of high school dropout 5 years later. Frequent attenders (≥4 contacts) had the highest odds of dropping out. Yet, boys who saw a GP and girls attending the school health services regularly over the previous year were less likely than their peers to drop out from high school. Adolescents who seek help at certain healthcare services can be at risk of dropping out of high school later. Health workers should pay particular attention to frequent attenders and offer follow-up when needed. However, boys who attended a GP regularly were more likely to continue to high school graduation, which may indicate a protective effect of having a regular and stable relationship with a GP.

15th International Conference on Human Antibodies and Hybridomas. 14-16 April 2010, Tiara Park Atlantico Hotel, Porto, Portugal.

PubMed

Kotlan, Beatrix

2010-11-01

Antibodies and antibody conjugates are currently one of the largest classes of new drug entities under development. These versatile molecules are being investigated for the treatment of many pathological conditions, such as cancer and infectious, inflammatory and autoimmune diseases. Antibodies can exert biological effects as naked antibodies by themselves, or can be used as delivery agents conjugated with various drugs (e.g., immunoconjugates) and as tools of multistep targeting. Site-specific delivery of therapeutic agents has been the ultimate goal of the pharmaceutical industry, as it has the potential to maximize drug efficiency while minimizing side effects. Antibodies have much potential for this objective. Thus, it is useful to summarize some of the main strategies currently being employed for the development of these diverse therapeutic molecules and to highlight the recent novelties in the field. These goals were the focus of the 15th International Conference on Human Antibodies and Hybridomas, held during 14-16 April 2010 in Porto, Portugal.

Clinical follow up of uniparental disomy 16: First data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dworniczak, B.; Koppers, B.; Bogdanova, N.

1994-09-01

Following the introduction of the concept of uniparental disomy (UPD) in 1980 by Engel this segregational anomaly is reported in an ever increasing number of patients. So far, several groups of individuals with an increased risk for UPD have been identified including abnormal carriers of familial balanced translocations or centric fusions, carriers of mosaic trisomies, and fetuses after prenatal diagnosis of confined placental mosaicism. A major pathogenetic mechanism appears to be post-meiotic chromosome loss in trisomic conceptuses. UPD was repeatedly observed in the fetus after diagnosis of mosaic or non-mosaic trisomies in the placenta which are usually considered {open_quotes}lethal{close_quotes} (i.e.more » trisomies 15 and 16). In an ongoing study to determine the incidence and clinical consequences of UPD we investigated the parental origin of chromosomes in the disomic cell line after prenatal diagnosis of mosaicism for various trisomies (e.g. 2, 7, 14, 15, and 16). At present, two maternal disomies 16 and one maternal disomy 15 were identified. Severe intrauterine growth retardation was a common symptome which, however, was also present in some but not all mosaics with a biparental origin of the chromosomes in question. While prognosis is clear in some instances (i.e. UPD 15) counseling can be extremely difficult in others, when imprinting effects and homozygosity for unknown recessive traits present in a parent have to be considered. To assess the clinical significance, detailed follow-up studies of proven cases of uniparental disomies are essential. First data of two cases with UPD 16 are presented.« less

25 CFR 163.15 - Advertisement of sales.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Advertisement of sales. 163.15 Section 163.15 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.15 Advertisement of sales. Except as provided in §§ 163.13, 163.14, 163.16, and 163.26 of this part, sales of forest...

7 CFR 4280.16 - REDL and REDG Loan terms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false REDL and REDG Loan terms. 4280.16 Section 4280.16 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... up to 2 years for Projects involving a Start-Up venture or a Community Facilities Project whether or...

Three-body model for the two-neutron emission of Be 16 [Three-body model for the two-neutron decay of 16Be

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lovell, A. E.; Nunes, F. M.; Thompson, I. J.

While diproton emission was first theorized in 1960 and first measured in 2002, it was first observed only in 2012. The measurement of 14Be in coincidence with two neutrons suggests that 16Be does decay through the simultaneous emission of two strongly correlated neutrons. In this study, we construct a full three-body model of 16Be (as 14Be + n + n) in order to investigate its configuration in the continuum and, in particular, the structure of its ground state. Here, in order to describe the three-body system, effective n – 14Be potentials were constructed, constrained by the experimental information on 15Be.more » The hyperspherical R-matrix method was used to solve the three-body scattering problem, and the resonance energy of 16Be was extracted from a phase-shift analysis. As a result, in order to reproduce the experimental resonance energy of 16Be within this three-body model, a three-body interaction was needed. For extracting the width of the ground state of 16Be, we use the full width at half maximum of the derivative of the three-body eigenphase shifts and the width of the three-body elastic scattering cross section. In conclusion, our results confirm a dineutron structure for 16Be, dependent on the internal structure of the subsystem 15Be.« less

Three-body model for the two-neutron emission of Be 16 [Three-body model for the two-neutron decay of 16Be

DOE PAGES

Lovell, A. E.; Nunes, F. M.; Thompson, I. J.

2017-03-10

While diproton emission was first theorized in 1960 and first measured in 2002, it was first observed only in 2012. The measurement of 14Be in coincidence with two neutrons suggests that 16Be does decay through the simultaneous emission of two strongly correlated neutrons. In this study, we construct a full three-body model of 16Be (as 14Be + n + n) in order to investigate its configuration in the continuum and, in particular, the structure of its ground state. Here, in order to describe the three-body system, effective n – 14Be potentials were constructed, constrained by the experimental information on 15Be.more » The hyperspherical R-matrix method was used to solve the three-body scattering problem, and the resonance energy of 16Be was extracted from a phase-shift analysis. As a result, in order to reproduce the experimental resonance energy of 16Be within this three-body model, a three-body interaction was needed. For extracting the width of the ground state of 16Be, we use the full width at half maximum of the derivative of the three-body eigenphase shifts and the width of the three-body elastic scattering cross section. In conclusion, our results confirm a dineutron structure for 16Be, dependent on the internal structure of the subsystem 15Be.« less

15 CFR 904.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... violations of those statutes: (1) American Fisheries Act of 1998, Public Law 105-277; (2) Anadromous Fish.... 972-972h; (14) Endangered Species Act of 1973, 16 U.S.C. 1531-1543; (15) Fish and Seafood Promotion... U.S.C. 9101 et seq.; (28) Pacific Salmon Treaty Act of 1985, 16 U.S.C. 3631-3644; (29) Shark Finning...

Discussing epigenetics in Southern California: a report from the International Symposium on Epigenetic Control and Cellular Plasticity, UCI, December 15-16, 2011.

PubMed

Rattner, Barbara P

2012-04-01

With the goal of discussing how epigenetic control and chromatin remodeling contribute to the various processes that lead to cellular plasticity and disease, this symposium marks the collaboration between the Institut National de la Santé et de la Recherche Médicale (INSERM) in France and the University of California, Irvine (UCI). Organized by Paolo Sassone-Corsi (UCI) and held at the Beckman Center of the National Academy of Sciences at the UCI campus December 15-16, 2011, this was the first of a series of international conferences on epigenetics dedicated to the scientific community in Southern California. The meeting also served as the official kick off for the newly formed Center for Epigenetics and Metabolism at the School of Medicine, UCI (http://cem.igb.uci.edu).

Search for dilute excited states in 16O

NASA Astrophysics Data System (ADS)

Ogloblin, A. A.; Danilov, A. N.; Demyanova, A. S.; Goncharov, S. A.; Belyaeva, T. L.

2016-11-01

The root mean square radii of 16O in the short-lived 0+ excited states were experimentally deduced for the first time from the analyses of α +16O diffraction scattering. Differential cross sections of the elastic and inelastic α +16O and 16O+16O scattering in the incident energy range from a few MeV/nucleon up to 100 MeV/nucleon were analyzed by the modified diffraction model. No significant radius enhancement in any state in comparison with the ground state was observed. This concerns, in particular, the 15.1-MeV 06+ state of 16O, located in the vicinity of the four-α -particle complete dissociation threshold, for which we did not confirm the "gigantic" size predicted by the α -particle condensation model. This result does not support the idea that 16O in the 06+ state has a dilute structure and can be considered as an analog of the famous 7.65-MeV 02+ Hoyle state of 12C.

16 CFR 313.15 - Other exceptions to notice and opt out requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... U.S.C. 1681 et seq.), or (ii) From a consumer report reported by a consumer reporting agency; (6) In... ACTS OF CONGRESS PRIVACY OF CONSUMER FINANCIAL INFORMATION Exceptions § 313.15 Other exceptions to... at the direction of the consumer, provided that the consumer has not revoked the consent or direction...

Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity

PubMed Central

Zaheer, R S; Wiehler, S; Hudy, M H; Traves, S L; Pelikan, J B; Leigh, R; Proud, D

2014-01-01

Human rhinovirus (HRV) infections trigger exacerbations of lower airway diseases. HRV infects human airway epithelial cells and induces proinflammatory and antiviral molecules that regulate the response to HRV infection. Interferon (IFN)-stimulated gene of 15 kDa (ISG15) has been shown to regulate other viruses. We now show that HRV-16 infection induces both intracellular epithelial ISG15 expression and ISG15 secretion in vitro. Moreover, ISG15 protein levels increased in nasal secretions of subjects with symptomatic HRV infections. HRV-16-induced ISG15 expression is transcriptionally regulated via an IFN regulatory factor pathway. ISG15 does not directly alter HRV replication but does modulate immune signaling via the viral sensor protein RIG-I to impact production of CXCL10, which has been linked to innate immunity to viruses. Extracellular ISG15 also alters CXCL10 production. We conclude that ISG15 has a complex role in host defense against HRV infection, and that additional studies are needed to clarify the role of this molecule. PMID:24448099

16 CFR 1203.12 - Test requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Test requirements. 1203.12 Section 1203.12... STANDARD FOR BICYCLE HELMETS The Standard § 1203.12 Test requirements. (a) Peripheral vision. All bicycle... bicycle helmet shall come off of the test headform when tested in accordance with § 1203.15 of this...

16 CFR 16.6 - Charter.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Charter. 16.6 Section 16.6 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.6 Charter. (a) No advisory committee established, utilized, reestablished or renewed by the...

16 CFR 16.14 - Amendments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Amendments. 16.14 Section 16.14 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.14 Amendments. (a) The charter of an advisory committee may be amended when the Commission...

16 CFR 16.3 - Policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy. 16.3 Section 16.3 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.3 Policy. (a) The Commission's policy shall be to: (1) Establish an advisory committee only...

Expansion of signal transduction by G proteins The second 15 years or so: From 3 to 16 α subunits plus βγ dimers

PubMed Central

Birnbaumer, Lutz

2007-01-01

The first 15 years, or so, brought the realization that there existed a G protein coupled signal transduction mechanism by which hormone receptors regulate adenylyl cyclases and the light receptor rhodopsin activates visual phosphodiesterase. Three G proteins, Gs, Gi and transducin (T) had been characterized as αβγ heterotrimers, and Gsα-GTP and Tα-GTP had been identified as the sigaling arms of Gs and T. These discoveries were made using classical biochemical approaches, and culminated in the purification of these G proteins. The second 15 years, or so, are the subject of the present review. This time coincided with the advent of powerful recombinant DNA techniques. Combined with the classical approaches, the field expanded the repertoire of G proteins from 3 to 16, discovered the superfamily of seven transmembrane G protein coupled receptors (GPCRs) – which is not addressed in this article – and uncovered an amazing repertoire of effector functions regulated not only by αGTP complexes but also by βγ dimers. Emphasis is placed in presenting how the field developed with the hope of conveying why many of the new findings were made. PMID:17258171

16 CFR 16.3 - Policy.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Policy. 16.3 Section 16.3 Commercial... MANAGEMENT § 16.3 Policy. (a) The Commission's policy shall be to: (1) Establish an advisory committee only... making policy decisions and determining action to be taken with respect to any matter considered by an...

18 CFR 16.13 - Standards and factors for issuing a new license.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Standards and factors for issuing a new license. 16.13 Section 16.13 Conservation of Power and Water Resources FEDERAL... and 15 of the Federal Power Act § 16.13 Standards and factors for issuing a new license. (a) In...

Performance Analysis of the Link-16/JTIDS Waveform With Concatenated Coding

DTIC Science & Technology

2009-09-01

noncoherent demodulation in terms of both required signal power and throughput. 15. NUMBER OF PAGES 101 14. SUBJECT TERMS Link-16/JTIDS, Reed-Solomon...Pulsed-Noise Interference (PNI), Additive White Gaussian Noise (AWGN), coherent detection, noncoherent detection. 16. PRICE CODE 17. SECURITY...than the existing Link-16/JTIDS waveform in both AWGN and PNI, for both coherent and noncoherent demodulation, in terms of both required signal

16 CFR 300.16 - Ornamentation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Ornamentation. 300.16 Section 300.16... REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the wool... § 300.23 of this part (Rule 23). [29 FR 6625, May 21, 1964, as amended at 45 FR 44261, July 1, 1980] ...

The cluster compound In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} containing Mo{sub 14} clusters and the new mono- and bi-capped trioctahedral Mo{sub 15} and Mo{sub 16} clusters: Synthesis, crystal structure, and electrical and magnetic properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gall, Philippe; Guizouarn, Thierry; Gougeon, Patrick, E-mail: Patrick.Gougeon@univ-rennes1.fr

2015-07-15

Single crystals of the new quaternary compound In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} were obtained by solid state reaction. The crystal structure was determined by single-crystal X-ray diffraction. In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} crystallizes in the orthorhombic space group Pbca with unit-cell parameters a=9.4432(14) Å, b=11.4828(12) Å, c=20.299(4) Å and Z=4. Full-matrix least-squares refinement on F{sup 2} using 3807 independent reflections for 219 refinable parameters resulted in R{sub 1}=0.0259 and wR{sub 2}=0.0591. The crystal structure contains in addition to Mo{sub 14} clusters the first examples of mono- and bi-capped trioctahedral Mo{sub 14} i.e. Mo{sub 15} and Mo{sub 16} clusters.more » The oxygen framework derives from a stacking along the a direction of close-packed layers with sequence (…ABAC…). The Mo–Mo distances range between 2.6938(5) and 2.8420(6) Å and the Mo–O distances between 1.879(5) and 2.250(3) Å, as usually observed in molybdenum oxide clusters. The indium atoms form In{sub 4}{sup 6+} bent chains with In–In distances of 2.6682(5) and 2.6622(8) Å and the Ti atoms are in highly distorted octahedral sites of oxygen atoms with Ti–O distances ranging between 1.865(4) and 2.161(4) Å. Magnetic susceptibility measurements confirm the presence of Ti{sup 4+} cations and the absence of localized moments on the Mo network. Electrical resistivity measurements on a single crystal of In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} show a semimetallic behavior. - Graphical abstract: We present here the synthesis, the crystal structure, and the electrical and magnetic properties of the new compound In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} in which Mo{sub 14} clusters coexist statistically with mono- and bi-capped trioctahedral Mo{sub 14} that is Mo{sub 15} and Mo{sub 16} clusters. - Highlights: • Single crystals of In{sub 4}Ti{sub 1.5}Mo{sub 0.5}Mo{sub 14}O{sub 26} were obtained by solid

12 CFR 573.16 - Protection of Fair Credit Reporting Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CONSUMER FINANCIAL INFORMATION Relation to Other Laws; Effective Date § 573.16 Protection of Fair Credit... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Protection of Fair Credit Reporting Act. 573.16... Fair Credit Reporting Act (15 U.S.C. 1681 et seq.), and no inference shall be drawn on the basis of the...

12 CFR 40.16 - Protection of Fair Credit Reporting Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CONSUMER FINANCIAL INFORMATION Relation to Other Laws; Effective Date § 40.16 Protection of Fair Credit... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Protection of Fair Credit Reporting Act. 40.16... Fair Credit Reporting Act (15 U.S.C. 1681 et seq.), and no inference shall be drawn on the basis of the...

12 CFR 716.16 - Protection of Fair Credit Reporting Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PRIVACY OF CONSUMER FINANCIAL INFORMATION Relation to Other Laws; Effective Date § 716.16 Protection of... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Protection of Fair Credit Reporting Act. 716.16... operation of the Fair Credit Reporting Act (15 U.S.C. 1681 et seq.), and no inference shall be drawn on the...

12 CFR 573.16 - Protection of Fair Credit Reporting Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Protection of Fair Credit Reporting Act. 573.16 Section 573.16 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY PRIVACY OF... Fair Credit Reporting Act (15 U.S.C. 1681 et seq.), and no inference shall be drawn on the basis of the...

14 CFR 21.15 - Application for type certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Application for type certificate. 21.15... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.15 Application for type certificate. Link to an amendment published at 74 FR 53385, October 16, 2009. (a) An application for a type certificate...

Gender and age-specific seroprevalence of human papillomavirus 16 and 18 in general population in Tehran, Iran.

PubMed

Aghakhani, Arezoo; Mamishi, Setareh; Sabeti, Shahram; Bidari-Zerehpoosh, Farahnaz; Banifazl, Mohammad; Bavand, Anahita; Ramezani, Amitis

2017-04-01

The assessment of the gender and age-specific seroprevalence of human papillomavirus (HPV) is essential for planning of HPV vaccine implementation into the preventive programs. In this study, we aimed to determine the age-specific seroprevalence of HPV-16 and 18 in both males and females in Tehran, Iran. Three hundred and seventy-eight women (10-35 years) and 162 men (10-25 years) from Tehran, Iran, were enrolled. Anti-HPV IgG antibodies against HPV-16 and HPV-18 were detected by ELISA using papillomavirus type 16 and 18 L1-capsids as antigen. HPV-16 antibody was detected in 15.6 and 13.6% of women and men, respectively. Antibody against HPV-18 was found positive in 12.7 and 8% of women and men, respectively. The highest seroprevalence of HPV-16 and 18 were seen in women aged 26-30 years (22.2 and 19.4%, respectively), and the lowest HPV-16 and 18 seropositivity rates were seen in males and females aged 10-15 years (9.3 and 1.9%, respectively). In our cohort of study, in males, both anti-HPV-16 and 18 increased after age 15 years, peaking in men aged 21-25 years. In women, both HPV-16 and 18 seropositivity increased after 15 years, declined at 21-25 years, peaked in women aged 26-30 years and again decreased after 30 years. Our data showed increasing exposure rate to high-risk HPV vaccine types in our studied population over 15 years of age. In order to prevent the HPV-related cancers, implementation of HPV vaccine into the national immunization program in Iran and vaccination of females and males less than 15 years of age are suggested.

16 CFR 16.8 - Closed meetings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Closed meetings. 16.8 Section 16.8... COMMITTEE MANAGEMENT § 16.8 Closed meetings. (a) Paragraphs (e), (f), and (g) of § 16.7 of this part, which require that meetings shall be open to the public and that the public shall be afforded an opportunity to...

15 CFR 806.16 - Rules and regulations for BE-10, Benchmark Survey of U.S. Direct Investment Abroad-2004.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Benchmark Survey of U.S. Direct Investment Abroad-2004. 806.16 Section 806.16 Commerce and Foreign Trade... COMMERCE DIRECT INVESTMENT SURVEYS § 806.16 Rules and regulations for BE-10, Benchmark Survey of U.S. Direct Investment Abroad—2004. A BE-10, Benchmark Survey of U.S. Direct Investment Abroad will be...

LSAT® Scores of Economics Majors: The 2015-16 Class Update and 15-Year History

ERIC Educational Resources Information Center

Nieswiadomy, Michael

2017-01-01

In this article, the author updates his prior studies of LSAT® scores (Nieswiadomy 1998, 2006, 2010, 2014) using current data for 2015-16 law school applicants, finding that economics majors remain at or near the top of all applicants. Results of the previous studies showing economics majors scored well on the LSAT® have been posted often on…

Streamflow, specific-conductance, and temperature data for Bayou and Little Bayou Creeks near Paducah, Kentucky, August 15 and 16, 1989

USGS Publications Warehouse

Evaldi, R.D.; McClain, D.L.

1989-01-01

Discharge, temperature, and specific conductance measurements were made August 15 and 16, 1989, at 74 main channel sites and seven flowing tributaries on Bayou and Little Bayou Creeks, Kentucky in the vicinity of the Paducah Gaseous Diffusion Plant. These measurements were made during base flow conditions to provide data for analysis of the interaction of surface and groundwater. The discharge of Bayou Creek was 0.30 cfs at the most upstream site, and 5.8 cfs at the most downstream site. Total measured tributary inflow of Bayou Creek was 5.7 cfs. Specific conductance values in the Bayou Creek watershed ranged from 208 to 489 microsiemens/cm, and water temperature ranged from 20.0 to 32.6 C. The discharge of Little Bayou Creek was 0.65 cfs at the most upstream site, and 1.8 cfs at the most downstream site. Total measured tributary inflow of Little Bayou Creek was 0.38 cfs. Specific conductance values in the Little Bayou Creek watershed ranged from 211 to 272 microsiemens/cm, and water temperature ranged from 14.5 to 24.9 C. (USGS)

An Unfinished Jigsaw: The 16+ Curriculum in the 1990s.

ERIC Educational Resources Information Center

Kershaw, Noel

Education reform in Great Britain during the last 15 years has been piecemeal, and all the pieces are not yet in place for broad and balanced post-16 education. The last 10 years of debate have achieved much common ground among the goals perceived by government, industry, and education. Three major ways of looking at the post-16 curriculum have…

16 CFR 1210.16 - Production testing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Production testing. 1210.16 Section 1210.16 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.16 Production testing. (a) General...

16 CFR 1061.1 - Scope and purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL APPLICATIONS FOR EXEMPTION FROM PREEMPTION § 1061.1 Scope and purpose. (a) This part applies to the submission and consideration of applications by...), section 16 of the Flammable Fabrics Act (FFA) (15 U.S.C. 1203), and section 7 of the Poison Prevention...

46 CFR 58.16-16 - Reducing regulators.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Reducing regulators. 58.16-16 Section 58.16-16 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-16 Reducing regulators...

16 CFR 1204.16 - Production testing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Production testing. 1204.16 Section 1204.16 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification § 1204.16 Production testing...

43 CFR 2.15 - Will I be charged fees?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Will I be charged fees? 2.15 Section 2.15... INFORMATION ACT Requests for Records under the FOIA § 2.15 Will I be charged fees? Bureaus will charge fees consistent with the provisions in §§ 2.16 and 2.17. The fee schedule in appendix C to this part applies to...

16 CFR 1212.16 - Production testing.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., the equipment used to manufacture the product, or the product's materials or design. The corrective... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Production testing. 1212.16 Section 1212.16... STANDARD FOR MULTI-PURPOSE LIGHTERS Certification Requirements § 1212.16 Production testing. (a) General...

16 CFR 1210.16 - Production testing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... in the manufacturing process, the assembly process, the equipment used to manufacture the product, or... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Production testing. 1210.16 Section 1210.16... STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.16 Production testing. (a) General...

Photogrammetry using Apollo 16 orbital photography, part B

NASA Technical Reports Server (NTRS)

Wu, S. S. C.; Schafer, F. J.; Jordan, R.; Nakata, G. M.

1972-01-01

Discussion is made of the Apollo 15 and 16 metric and panoramic cameras which provided photographs for accurate topographic portrayal of the lunar surface using photogrammetric methods. Nine stereoscopic models of Apollo 16 metric photographs and three models of panoramic photographs were evaluated photogrammetrically in support of the Apollo 16 geologic investigations. Four of the models were used to collect profile data for crater morphology studies; three models were used to collect evaluation data for the frequency distributions of lunar slopes; one model was used to prepare a map of the Apollo 16 traverse area; and one model was used to determine elevations of the Cayley Formation. The remaining three models were used to test photogrammetric techniques using oblique metric and panoramic camera photographs. Two preliminary contour maps were compiled and a high-oblique metric photograph was rectified.

50 CFR 15.1 - Purpose of regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BIRD CONSERVATION ACT Introduction and General Provisions § 15.1 Purpose of regulations. The regulations in this part implement the Wild Bird Conservation Act of 1992, Pub. L. 102-440, 16 U.S.C. 4901...

TSCA Section 5(a)(3)(C) Determination for Microbial Commercial Activity Notice (MCAN) J-16-0011, J-16-0012, J-16-0013, J-16-0014, J-16-0015, and J-16-0016

EPA Pesticide Factsheets

This document describes EPA's Microbial Commercial Activity Notice (MCAN) review determination under amended TSCA for J-16-0011, J-16-0012, J-16-0013, J-16-0014, J-16-0015, and J-16-0016, a biofuel producing organism.

16. Photocopy of photograph (Photographer unknown, Date unknown) SUPPOSED OLDEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of photograph (Photographer unknown, Date unknown) SUPPOSED OLDEST VIEW OF MAIN AND EAST ELEVATIONS - Caleb Pusey House, 15 Race Street (Landingford Plantation), Upland, Delaware County, PA

16 CFR 1000.11 - Delegation of functions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Delegation of functions. 1000.11 Section... FUNCTIONS § 1000.11 Delegation of functions. Section 27(b)(9) of the Consumer Product Safety Act (15 U.S.C... to issue subpoenas, to any officer or employee of the Commission. Delegations are documented in the...

16 CFR 698.1 - Authority and purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Authority and purpose. 698.1 Section 698.1 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT MODEL FORMS AND DISCLOSURES § 698... provisions of the Fair Credit Reporting Act (15 U.S.C. 1681 et seq.), as amended by the Consumer Credit...

Composition of primary cosmic rays at energies 10(15) to approximately 10(16) eV

NASA Technical Reports Server (NTRS)

Amenomori, M.; Konishi, E.; Hotta, N.; Mizutani, K.; Kasahara, K.; Kobayashi, T.; Mikumo, E.; Sato, K.; Yuda, T.; Mito, I.

1985-01-01

The sigma epsilon gamma spectrum in 1 approx. 5 x 1000 TV observed at Mt. Fuji suggests that the flux of primary protons 10 to the 15 approx 10th eV is lower by a factor of 2 approx. 3 than a simple extrapolation from lower energies; the integral proton spectrum tends to be steeper than around to the power V and the spectral index tends to be steeper than Epsilon to the -17th power around 10 to the 14th power eV and the spectral index becomes approx. 2.0 around 10 to the 15th power eV. If the total flux of primary particles has no steepening up to approx 10 to the 15th power eV, than the fraction of primary protons to the total flux should be approx 20% in contrast to approx 45% at lower energies.

Radiation protection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2, and the combination of both agents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, W.R.

1987-08-01

The survival of murine intestinal clonogenic cells (ICC) and the survival of mice after whole-body exposure to /sup 137/Cs irradiation were used to measure radiation protection by ethiophos (WR-2721), 16,16-dimethyl prostaglandin E2, and the combination of the two. Doses from 2 to 12.5 mg/mouse of WR-2721 increased cell survival linearly from 3.2 +/- 0.3 in controls given 15.0 Gy to 93.1 +/- 5.2 per jejunal circumference. In contrast, 16,16-dm PGE2 increased ICC survival at 15.0 Gy rapidly from 1 to 10 micrograms/mouse, followed by a plateau up to 100 micrograms/mouse. Animal survival at 6 days (LD50/6) increased from 16.3 +/-more » 0.4 Gy (95% confidence limits) in controls to 20.3 +/- 0.6 Gy in the PG-treated animals. WR-2721 increased the LD50/6 to 26.1 +/- 1.4 Gy. The dose modification factors were 1.25 and 1.60, respectively. The combination of agents increased ICC survival above that seen with each agent alone up to 8 mg WR-2721, above which no additional protection was seen. Animals given 10 micrograms PG plus 10 mg WR-2721 survived longer than with either agent given alone. The LD50/6 was 36.3 +/- 1.8 Gy for a dose modification factor (DMF) of 2.23. In addition, the slope of the probit curve was reduced from those of each agent alone. PG-induced changes in villus epithelial cell morphology and survival may account, in part, for these observations. The results suggest that either the mechanisms for these two types of radiation protectors are different or they act on separate subcellular targets which are critical to survival from radiation injury.« less

16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

Code of Federal Regulations, 2014 CFR

2014-01-01

... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity under...

16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

Code of Federal Regulations, 2013 CFR

2013-01-01

... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity under...

16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

Code of Federal Regulations, 2012 CFR

2012-01-01

... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity under...

16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

Code of Federal Regulations, 2011 CFR

2011-01-01

... provide other information and granting immunity. 2.15 Section 2.15 Commercial Practices FEDERAL TRADE... and granting immunity. (a) The Bureau Director, Deputy Directors, and Assistant Directors in the... issuance of an order requiring a witness to testify or provide other information granting immunity under...

Proton-Detected 15N NMR-Spectroscopy and Imaging

NASA Astrophysics Data System (ADS)

Freeman, D.; Sailasuta, N.; Sukumar, S.; Hurd, R. E.

1993-10-01

Proton detection of nitrogen-15, using gradients for coherence selection, was determined to be an effective method for obtaining spectra of 15N-labeled metabolites from extracts and biopsies of tissue infused with [15N] ammonium chloride. The advantage of gradient selection of coherence was best demonstrated by the almost complete single-shot elimination of solvent water in extracts and tissue water in biopsies. As a single-acquisition editing method in which only protons attached to 15N are detected, the potential limitations of dynamic range and motion are also reduced. Gradient-enhanced heteronuclear multiple-quantum coherence (1H[15N] HMQC) was compared with conventional HMQC, and despite selection of only one of the two heteronuclear pathways, GE-HMQC was found to be more effective for resolving the desired signal for dilute solutions; and with a single scan. In addition, effective water elimination made it possible to use the resolution advantage of a frequency-encoding dimension in proton-detected 15N imaging experiments. The limit of detection of the method at 500 MHz was 0.7 mM in 16 scans from a total volume of 400 μl. Signals from tissue extracts were observable in less than one minute for kidney, heart, brain, and muscle. Proton-detected 15N GE-HMQC images with a voxel size of 39 × 78 × 625 μm were obtained at 600 MHz from a 4 mM (1.6 μmol) 15N urea sample in less than four hours. Distribution of [15N] urea in the kidney was observed in a 600 MHz GE-HMQC image of the papilla and some cortical structures.

Alpha Cluster Structure in 16O

NASA Astrophysics Data System (ADS)

Dias Rodrigues, Márcia Regina; Borello-Lewin, Thereza; Miyake, Hideaki; Cappuzzello, Francesco; Cavallaro, Manuela; Duarte, José Luciano Miranda; Lima Rodrigues, Cleber; de Souza, Marco Antonio; Horodynski-Matsushigue, Brighitta; Cunsolo, Angelo; Foti, Antonio; Mitsuo Ukita, Gilberto; Neto de Faria, Pedro; Agodi, Clementina; De Napoli, Marzio; Nicolosi, Dario; Bondì, Dario; Carbone, Diana; Tropea, Stefania

2014-03-01

The main purpose of the present work is the investigation of the α-cluster phenomenon in 16O. The 12C(6Li,d)16O reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion detection technique. Resonant states around 4α threshold were measured and an energy resolution of 15 keV allows to define states previously unresolved. The angular distributions of the absolute cross sections were determined in a range of 4-40 degree in the center of mass system. The upper limit for the resonance widths was obtained, indicating that the a cluster structure information in this region should be revised.

CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells.

PubMed

Pahl, Jens H W; Koch, Joachim; Götz, Jana-Julia; Arnold, Annette; Reusch, Uwe; Gantke, Thorsten; Rajkovic, Erich; Treder, Martin; Cerwenka, Adelheid

2018-05-01

CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibody-dependent cytotoxicity have remained poorly elucidated. Here, we investigated NK cell responses after exposure to therapeutic antibodies such as the tetravalent bispecific antibody AFM13 (CD30/CD16A), designed for the treatment of Hodgkin lymphoma and other CD30 + lymphomas. Our results reveal that CD16A engagement enhanced subsequent IL2- and IL15-driven NK cell proliferation and expansion. This effect involved the upregulation of CD25 (IL2Rα) and CD132 (γ c ) on NK cells, resulting in increased sensitivity to low-dose IL2 or to IL15. CD16A engagement initially induced NK cell cytotoxicity. The lower NK cell reactivity observed 1 day after CD16A engagement could be recovered by reculture in IL2 or IL15. After reculture in IL2 or IL15, these CD16A-experienced NK cells exerted more vigorous IFNγ production upon restimulation with tumor cells or cytokines. Importantly, after reculture, CD16A-experienced NK cells also exerted increased cytotoxicity toward different tumor targets, mainly through the activating NK cell receptor NKG2D. Our findings uncover a role for CD16A engagement in priming NK cell responses to restimulation by cytokines and tumor cells, indicative of a memory-like functionality. Our study suggests that combination of AFM13 with IL2 or IL15 may boost NK cell antitumor activity in patients by expanding tumor-reactive NK cells and enhancing NK cell reactivity, even upon repeated tumor encounters. Cancer Immunol Res; 6(5); 517-27. ©2018 AACR . ©2018 American Association for Cancer Research.

16 CFR § 1203.12 - Test requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... stability. No bicycle helmet shall come off of the test headform when tested in accordance with § 1203.15 of... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Test requirements. § 1203.12 Section Â... SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.12 Test requirements. (a) Peripheral vision. All...

Application Summary Report 22: LED MR16 Lamps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Royer, Michael P.

2014-07-23

This report analyzes the independently tested photometric performance of 27 LED MR16 lamps. It describes initial performance based on light output, efficacy, distribution, color quality, electrical characteristics, and form factor, with comparisons to a selection of benchmark halogen MR16s and ENERGY STAR qualification thresholds. Three types of products were targeted. First, CALiPER sought 3000 K lamps with the highest rated lumen output (i.e., at least 500 lm) or a claim of equivalency to a 50 W halogen MR16 or higher. The test results indicate that while the initial performance of LED MR16s has improved across the board, market-available products stillmore » do not produce the lumen output and center beam intensity of typical 50 W halogen MR16 lamps. In fact, most of the 18 lamps in this category had lower lumen output and center beam intensity than a typical 35 W halogen MR16 lamp. Second, CALiPER sought lamps with a CRI of 90 or greater. Only four manufacturers were identified with a product in this category. CALiPER testing confirmed the performance of these lamps, which are a good option for applications where high color fidelity is needed. A vast majority of the LED MR16 lamps have a CRI in the low 80s; this is generally acceptable for ambient lighting, but may not always be acceptable for focal lighting. For typical LED packages, there is a fundamental tradeoff between CRI and efficacy, but the lamps in the high-CRI group in this report still offer comparable performance to the rest of the Series 22 products in other performance areas. Finally, CALiPER sought lamps with a narrow distribution, denoted as a beam angle less than 15°. Five such lamps were purchased. Notably, no lamp was identified as having high lumen output (500 lumens or greater), high CRI (90 or greater), a narrow distribution (15° or less), and an efficacy greater than 60 lm/W. This would be an important achievement for LED MR16s especially if output could reach approximately 700 800

Transition to an IP Environment. A Report of the Annual Aspen Institute Conference on Telecommunications Policy (15th, Aspen, Colorado, August 12-16, 2000) with Thoughts on the Implications of Technological Change for Telecommunications Policy.

ERIC Educational Resources Information Center

Entman, Robert M.; Katz, Michael L.

The Aspen Institute's Communications and Society Program convened leaders and experts in the telecommunications and related fields to address telecommunications regulation in an IP (Internet Protocols) environment at the 15th annual Aspen Institute Telecommunications Policy Conference (Aspen, Colorado, August 12-16, 2000). The report from this…

Microstructure-strength relations in a hardenable stainless steel with 16 pct Cr, 1.5 pct Mo, and 5 pct Ni

NASA Astrophysics Data System (ADS)

Grobner, P. J.; Blšs, V.

1984-07-01

Metallographic studies have been conducted on a 0.024 pct C-16 pct Cr-1.5 pct Mo-5 pct Ni stainless steel to study the phase reactions associated with heat treatments and investigate the strengthening mechanisms of the steel. In the normalized condition, air cooled from 1010 °C, the microstructure consists of 20 pct ferrite and 80 pct martensite. Tempering in a temperature range between 500 and 600 °C results in a gradual transformation of martensite to a fine mixture of ferrite and austenite. At higher tempering temperatures, between 600 and 800 °C, progressively larger quantities of austenite form and are converted during cooling to proportionally increasing amounts of fresh martensite. The amount of retained austenite in the microstructure is reduced to zero at 800 °C, and the microstructure contains 65 pct re-formed martensite and 35 pct total ferrite. Chromium rich M23C6 carbides precipitate in the single tempered microstructures. The principal strengthening is produced by the presence of martensite in the microstructure. Additional strengthening is provided by a second tempering treatment at 400 °C due to the precipitation of ultrafine (Cr, Mo) (C,N) particles in the ferrite.

AFTI/F-16

NASA Technical Reports Server (NTRS)

1991-01-01

the aircraft back to level flight. The AFTI F-16 program ended at Dryden on November 4, 1997 after 15 years and over 700 research flights. The USAF continued to fly the aircraft until retiring it to the Air Force Museum on January 9, 2001.

AFTI/F-16

NASA Technical Reports Server (NTRS)

1992-01-01

was designed to take command in such emergencies and bring the aircraft back to level flight. The AFTI F-16 program ended at Dryden on November 4, 1997 after 15 years and over 700 research flights. The USAF continued to fly the aircraft until retiring it to the Air Force Museum on January 9, 2001.

16 CFR 1112.15 - When can a third party conformity assessment body apply for CPSC acceptance for a particular CPSC...

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Section 4.37, Yo-Yo Elastic Tether Toys (HH) Section 4.38, Magnets (except labeling and/or instructional... Infant Bath Seats; (3) 16 CFR part 1216, Safety Standard for Infant Walkers; (4) 16 CFR part 1217, Safety... Flammability of Mattresses and Mattress Pads (FF 4-72, amended); (27) 16 CFR part 1633, Standard for the...

Construction diagrams, geophysical logs, and lithologic descriptions for boreholes USGS 103, 105, 108, 131, 135, NRF-15, and NRF-16, Idaho National Laboratory, Idaho

USGS Publications Warehouse

Hodges, Mary K.V.; Orr, Stephanie M.; Potter, Katherine E.; LeMaitre, Tynan

2012-01-01

This report, prepared in cooperation with the U.S. Department of Energy, summarizes construction, geophysical, and lithologic data collected from about 4,509 feet of core from seven boreholes deepened or drilled by the U.S. Geological Survey (USGS), Idaho National Laboratory (INL) Project Office, from 2006 to 2009 at the INL. USGS 103, 105, 108, and 131 were deepened and cored from 759 to 1,307 feet, 800 to 1,409 feet, 760 to 1,218 feet, and 808 to 1,239 feet, respectively. Boreholes USGS 135, NRF-15, and NRF-16 were drilled and continuously cored from land surface to 1,198, 759, and 425 feet, respectively. Cores were photographed and digitally logged by using commercially available software. Borehole descriptions summarize location, completion date, and amount and type of core recovered.

Preliminary study of the Suomi NPP VIIRS detector-level spectral response function effects for the long-wave infrared bands M15 and M16

NASA Astrophysics Data System (ADS)

Padula, Francis; Cao, Changyong

2014-09-01

The Suomi NPP Visible Infrared Imaging Radiometer Suite (VIIRS) Sea Surface Temperature (SST) Environmental Data Record (EDR) team observed an anomalous striping pattern in the SST data. To assess possible causes due to the detector-level Spectral Response Functions (SRFs), a study was conducted to compare the radiometric response of the detector-level and operation band averaged SRFs of VIIRS bands M15 & M16 using simulated blackbody radiance data and clear-sky ocean radiances under different atmospheric conditions. It was concluded that the SST product is likely impacted by small differences in detector-level SRFs, and that if users require optimal system performance detector-level processing is recommended. Future work will investigate potential SDR product improvements through detector-level processing in support of the generation of Suomi NPP VIIRS climate quality SDRs.

[A clinical analysis of 16 patients with maternal listeriosis].

PubMed

Wang, Peng; Chen, Yingqian; Wang, Huanling; Yang, Shuang; Xu, Yingchun; Li, Taisheng

2015-09-01

To summarize the clinical characteristics and outcome of maternal listeriosis so as to improve the understanding of disease and the level of diagnosis and treatment. Retrospectively, 16 cases of maternal listeriosis, who were treated at Peking Union Medical College Hospital between March 2007 and December 2014 were reviewed. Maternal listeriosis is defined when a pregnant woman presents with symptoms as listeriosis, meanwhile Listeria monocytogenes is isolated from sterile tissue or peripheral blood, or from a non-sterile site (uterus swab) or pathological evidence of chorioamnionitis. The neonatal listeriosis is diagnosed as acute listeria sepsis. The mean age of these 16 patients was (30.0 ± 3.9) years old. There were 1, 8, 7 patients with listeriosis diagnosed in the first, second and third trimester of pregnancy, respectively. All had an acute onset of illness (≤ 2 weeks), the median time from onset to presentation was 2.5 days. Clinical manifestations included fever (93.8%, 15/16), leukocytosis (78.6%, 11/14), chorioamnionitis (77.8%, 7/9), gastrointestinal symptoms (37.5%, 6/16) and fetal movement decrease (31.3%, 5/16). Listeria monocytogenes were isolated from blood (6 cases), uterus swab (6 cases), blood plus uterus swab (1 case), and neonates (3 cases). All maternal cases recovered well after the termination of pregnancy, even none of them had received empiric antibiotics sensitive to listeria. A very high proportion of adverse pregnancy outcomes occurred (15/16, 93.8%). There were 8 fetal losses. Seven neonates were complicated with listeria sepsis and treated successfully. The patients with maternal listeriosis commonly presented with acute fever and an extremely high incidence of adverse pregnancy outcomes, however empiric antibiotics can hardly cover this pathogenic bacterium. So both pregnant women and clinicians should maintain a high level of vigilance against listeriosis and pay more attention to dietetic hygiene.

16 CFR 16.11 - Annual comprehensive review.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Annual comprehensive review. 16.11 Section 16.11 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.11 Annual comprehensive review. (a) The Commission shall conduct an...

16 CFR 1018.16 - Membership selection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Membership selection. 1018.16 Section 1018... Establishment of Advisory Committees § 1018.16 Membership selection. (a) Whenever new applicants are required... Candidate Evaluation Panel, using selection criteria established by the Commission, shall evaluate all...

16 CFR 1018.16 - Membership selection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Membership selection. 1018.16 Section 1018... Establishment of Advisory Committees § 1018.16 Membership selection. (a) Whenever new applicants are required... Candidate Evaluation Panel, using selection criteria established by the Commission, shall evaluate all...

16 CFR 1018.16 - Membership selection.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Membership selection. 1018.16 Section 1018... Establishment of Advisory Committees § 1018.16 Membership selection. (a) Whenever new applicants are required... Candidate Evaluation Panel, using selection criteria established by the Commission, shall evaluate all...

16 CFR 1018.16 - Membership selection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Membership selection. 1018.16 Section 1018... Establishment of Advisory Committees § 1018.16 Membership selection. (a) Whenever new applicants are required... Candidate Evaluation Panel, using selection criteria established by the Commission, shall evaluate all...

16 CFR § 1210.16 - Production testing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Production testing. § 1210.16 Section § 1210.16 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.16 Production testing. (a...

7. ROCKET SLED ON DECK OF TEST STAND 15. Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. ROCKET SLED ON DECK OF TEST STAND 1-5. Photo no. "6085, G-EAFB-16 SEP 52." Looking south to machine shop. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Archaeological Evaluation of the Paris Road Site (16 or 41), Orleans Parish, Louisiana.

DTIC Science & Technology

1984-03-01

Little Woods middens (16 OR 1 to 16 OR 5) " located northwest of the study area. Unfortunately, the records and most of the artifacts have been lost (Ford...the Little Woods and Big Oak Island (16 OR 6) sites in Orleans Parish led to -’. a definition of Tchefuncte material culture. Shenkel’s 1972 to 1974...the Little Woods Middens (16 OR 1-5) situated along the south shore of Lake Pontchartrain. Unfortunately, Czajkowski’s notes and artifact records

46 CFR 15.710 - Working hours.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Limitations and Qualifying Factors § 15.710 Working hours. In addition to prescribing watch requirements, 46 U..., prescribes certain rest periods, and prohibits unnecessary work on Sundays and certain holidays when the..., (d) Performing fire, lifeboat, or other drills in port or at sea. [CGD 81-059, 52 FR 38652, Oct. 16...

16 CFR 16.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Purpose and scope. 16.1 Section 16.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.1 Purpose and scope. (a) The regulations in this part implement the Federal...

15 CFR 16.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... term consumer product means any article produced or distributed for sale to a consumer for the use... performance characteristic means a performance characteristic of a consumer product that can be measured in an objective manner with respect to a given consumer product. (g) The term Specification means a Performance...

16 CFR 1025.15 - Time.

Code of Federal Regulations, 2010 CFR

2010-01-01

... time prescribed or allowed by these rules, the day of the act, event, or default from which the... be included, unless it is a Saturday, a Sunday, or a legal holiday, in which event the period runs... mail, three (3) days shall be added to the prescribed period. (c) Extensions. For good cause shown, the...

16 CFR 1025.15 - Time.

Code of Federal Regulations, 2014 CFR

2014-01-01

... time prescribed or allowed by these rules, the day of the act, event, or default from which the... be included, unless it is a Saturday, a Sunday, or a legal holiday, in which event the period runs... mail, three (3) days shall be added to the prescribed period. (c) Extensions. For good cause shown, the...

16 CFR 1025.15 - Time.

Code of Federal Regulations, 2011 CFR

2011-01-01

... time prescribed or allowed by these rules, the day of the act, event, or default from which the... be included, unless it is a Saturday, a Sunday, or a legal holiday, in which event the period runs... mail, three (3) days shall be added to the prescribed period. (c) Extensions. For good cause shown, the...

16 CFR 1025.15 - Time.

Code of Federal Regulations, 2012 CFR

2012-01-01

... time prescribed or allowed by these rules, the day of the act, event, or default from which the... be included, unless it is a Saturday, a Sunday, or a legal holiday, in which event the period runs... mail, three (3) days shall be added to the prescribed period. (c) Extensions. For good cause shown, the...

15 CFR 265.16 - Parking.

Code of Federal Regulations, 2010 CFR

2010-01-01

... GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY... Parking. No person, unless otherwise authorized by a posted traffic sign or directed by a uniformed guard, shall stand or park a motor vehicle: (a) On a sidewalk; (b) Within an intersection or within a crosswalk...

15 CFR 265.16 - Parking.

Code of Federal Regulations, 2011 CFR

2011-01-01

... GOVERNING TRAFFIC AND CONDUCT ON THE GROUNDS OF THE NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY... Parking. No person, unless otherwise authorized by a posted traffic sign or directed by a uniformed guard, shall stand or park a motor vehicle: (a) On a sidewalk; (b) Within an intersection or within a crosswalk...

16 CFR 1210.15 - Specifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... of all dimensions, force requirements, or other features that could affect the child-resistance of the lighter, including the manufacturer's tolerances for each such dimension or force requirement. (3...

16 CFR 1212.15 - Specifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

...-resistant features. (2) A detailed description of all dimensions, force requirements, or other features that... for each such dimension or force requirement. (3) Any further information, including, but not limited...

16 CFR 1212.15 - Specifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

...-resistant features. (2) A detailed description of all dimensions, force requirements, or other features that... for each such dimension or force requirement. (3) Any further information, including, but not limited...

16 CFR 1210.15 - Specifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... of all dimensions, force requirements, or other features that could affect the child-resistance of the lighter, including the manufacturer's tolerances for each such dimension or force requirement. (3...

16 CFR 1212.15 - Specifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

...-resistant features. (2) A detailed description of all dimensions, force requirements, or other features that... for each such dimension or force requirement. (3) Any further information, including, but not limited...

Calibration of the NASA GRC 16 In. Mass-Flow Plug

NASA Technical Reports Server (NTRS)

Davis, David O.; Friedlander, David J.; Saunders, J. David; Frate, Franco C.; Foster, Lancert E.

2012-01-01

The results of an experimental calibration of the NASA Glenn Research Center 16 in. Mass-Flow Plug (MFP) are presented and compared to a previously obtained calibration of a 15 in. Mass-Flow Plug. An ASME low-beta, long-radius nozzle was used as the calibration reference. The discharge coefficient for the ASME nozzle was obtained by numerically simulating the flow through the nozzle from the WIND-US code. The results showed agreement between the 15 in. and 16 in. MFPs for area ratios (MFP to pipe area ratio) greater than 0.6 but deviate at area ratios below this value for reasons that are not fully understood. A general uncertainty analysis was also performed and indicates that large uncertainties in the calibration are present for low MFP area ratios.

Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population.

PubMed

do Nascimento Borges, Bárbara; Burbano, Rommel Mario Rodriguez; Harada, Maria Lúcia

2013-08-01

Gastric cancer is a major public health problem in Pará state, where studies suggest complex genetic and epigenetic profiles of the population, indicating the need for the identification of molecular markers for this tumor type. In the present study, the methylation patterns of three genes [p16 (INK4A), p15 (INK4B), and adenomatous polyposis coli (APC)] were assessed in patients with gastric adenocarcinoma from Pará state in order to identify possible molecular markers of gastric carcinogenesis. DNA samples from tumoral and non-tumoral gastric tissues were modified with sodium bisulfite. A fragment of the promoter region of each gene was amplified and sequenced, and samples with more than 20 % of methylated CpG sites were considered hypermethylated. The correlation between the methylation pattern of the selected genes and the MTHFR C677T polymorphism, as well as the relationship between APC and CDH1 methylation, were evaluated. The results suggest that APC hypermethylation is an age-specific marker of gastric carcinogenesis, and the concordance of this event with CDH1 hypermethylation suggests that the Wnt pathway has an important role in gastric carcinogenesis. While the hypermethylation pattern of p15 (INK4B) seems to be an earlier event in this type of tumor, the hypomethylated status of this gene seems to be correlated to the C677T MTHFR TT genotype. On the other hand, the observed pattern of p16 (INK4A) hypermethylation suggests that this event is a good marker for the gastric cancer pathway in the Pará state population.

Low-Timing-Jitter Near-Infrared Single-Photon-Sensitive 16-Channel Intensified-Photodiode Detector

NASA Technical Reports Server (NTRS)

Krainak, Michael A.; Lu, Wei; Yang, Guangning; Sun, Xiaoli; Sykora, Derek; Jurkovic, Mike; Aebi, Verle; Costello, Ken; Burns, Richard

2011-01-01

We developed a 16-channel InGaAsP photocathode intensified-photodiode (IPD) detector with 78 ps (1-sigma) timing-jitter, less than 500 ps FWHM impulse response, greater than 15% quantum efficiency at 1064 nm wavelength with 131 kcps dark counts at 15 C.

[Teenagers' views and needs on sexual and emotional education. Survey among 15- to 16-year-old boys and girls].

PubMed

Verdure, F; Rouquette, A; Delori, M; Aspeele, F; Fanello, S

2010-03-01

Teenagers have very particular needs and their healthcare must be adapted to these needs. Despite all the modern means of communication and education, problems related to sex and sexuality have an effect on their well-being. Sex education has improved in the last 40 years, but what is today's situation? In the Maine-et-Loire region of France, approximately 100 15- to 16-year-olds responded to a questionnaire, giving their views on the nature and quality of the sexual and emotional education they received. It appears that it falls very short of the legal requirements and that it is often inappropriate to the needs of young people. To improve sexual prevention, it is necessary to start early to provide sexual and emotional education and to increase the opportunities and the diversity of speakers presenting themes of importance to young people. The speaker should preferably be young and use lively means of communication and role-plays to normalize sex education. The most important aspects are respecting this young population as well as opening and maintaining communication with them, which will help them make better choices toward a better future. Promoting sex education is part of a global approach to healthy lifestyles and requires a national strategy, cooperation between the interested parties, and an adequate budget. Copyright 2009 Elsevier Masson SAS. All rights reserved.

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

16 CFR 1211.12 - Requirements for edge sensors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Requirements for edge sensors. 1211.12... Requirements for edge sensors. (a) Normal operation test. (1) When installed on a representative door edge, an edge sensor shall actuate upon the application of a 15 pounds (66.7 N) or less force in the direction...

16 CFR 1211.12 - Requirements for edge sensors.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Requirements for edge sensors. 1211.12... Requirements for edge sensors. (a) Normal operation test. (1) When installed on a representative door edge, an edge sensor shall actuate upon the application of a 15 pounds (66.7 N) or less force in the direction...

30 CFR 904.15 - Approval of Arkansas regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), (g), (h), .38; 784.27; 800.11(b)(2); 815.15(c)(2), (3), (4), .17(a), (b); 816.49(b)(7), (c)(2), .84(b..., 1983 March 16, 1984 ASCMRC 771.25 (a)(2); 776(c)(1), (2), (4), (5)(i), (ii); 842(c). May 21, 1985...; 761.12(b)(2), (e)(1), (2), (3); .15; 762.5; 764.13, .15(a)(1); 771.23(c)(4); 776.12, (a)(3)(vi), .14(a...

16 CFR 1500.83 - Exemptions for small packages, minor hazards, and special circumstances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the substances named in this subparagraph. (15) Cellulose sponges are exempt from the labeling...: (i) The cellulose sponge does not contain over 15 percent by weight of diethylene glycol; and (ii... liquid is within the sponge as marketed. (16) Containers of substances which include salt (sodium...

Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart.

PubMed

DeGrado, T R; Holden, J E; Ng, C K; Raffel, D M; Gatley, S J

1988-01-01

Time courses of radioactivity (residue curves) were obtained following bolus injection into working rat hearts of two 125I-labeled long chain fatty acids: 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA). Residue curves were analyzed in terms of a rapid vascular washout component, an early tissue clearance component, and a very slow late component. For IHDA and IPPA in control hearts, early myocardial clearance kinetics were rate limited by the diffusion of catabolites. Sensitivity of the kinetics to impaired fatty acid oxidation was examination by pretreatment of animals with 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA). Decreased fatty acid oxidation was indicated in IHDA and IPPA residue curves by a decrease in the relative size of the early clearance component. Analysis of radiolabeled species in coronary effluent and heart homogenates showed that back diffusion of IPPA was slower than that of IHDA; this discrepancy was most apparent in POCA hearts. In vitro binding assays suggested higher tissue:albumin relative affinity for IPPA than for IHDA. Thus, IPPA early clearance kinetics were more closely related to the clearance of labeled catabolite(s) and were therefore more sensitive to the oxidation rate of long chain fatty acids.

Apollo 12, 15, and 16 lunar surface magnetometer experiment data analysis

NASA Technical Reports Server (NTRS)

Sonett, C. P.

1975-01-01

The polarization of magnetometer signals detected at the Apollo 15 Hadley site by the lunar surface magnetometer has been studied to determine the source of the signal anisotropy which is observed and caused by the polarization. Instrument and data chain malfunction (cross-talk) seems ruled out. The source appears real and apparently connected with the Imbrium basin using reasonable inferences regarding the electromagnetic structure of the Moon. A theory is developed using moons with holes and conducting caps where the Imbrium basin is; results of calculations are consistent, though not unique, in specifying an anomaly in the electrical conductivity underlying Mare Imbrium. Distinct differences are noted from plasma sheet and diamagnetic cavity transfer functions, but the lobes appear, as for all other data, not to be vacuum for study of the moon. A discussion is given of problems connected with transfer of data, software, and theoretical programs from NASA Ames Research Center to the University of Arizona, and a summary is given of the conversion from IBM to CDC formats.

Progress report on a new search for free e/3 quarks in the cores of 10(15) - 10(16) eV air showers

NASA Technical Reports Server (NTRS)

Hodson, A. L.; Bull, R. M.; Taylor, R. S.; Belford, C. H.

1985-01-01

The Leeds 3 sq m Wilson cloud chamber is being used in a new search for free e/3 quarks close to the axes of 10 to the 15th power - 10 to the 16th power eV air showers. A ratio trigger circuit is used to detect the incidence of air shower cores; the position of the shower center and the axis direction are determined from photographs of current-limited spark chambers. It is thus possible, for the first time, to know where we have looked for quarks in air showers and to select for scanning only those cloud chamber photographs where we have good evidence that the shower axis was close to the chamber. 250 g/sq cm of lead/concrete absorber above the cloud chamber serve to reduce particle densities and make a quark search possible very close to the shower axes. The current status of the search is given.

16 CFR 16.4 - Advisory Committee Management Officer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

16 CFR 16.4 - Advisory Committee Management Officer.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

16 CFR 16.4 - Advisory Committee Management Officer.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

16 CFR 16.4 - Advisory Committee Management Officer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

16 CFR 16.13 - Renewal of advisory committees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Renewal of advisory committees. 16.13 Section 16.13 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.13 Renewal of advisory committees. (a) Any advisory committee...

16 CFR 16.12 - Termination of advisory committees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Termination of advisory committees. 16.12 Section 16.12 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.12 Termination of advisory committees. Any advisory committee shall...

16 CFR 16.4 - Advisory Committee Management Officer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

Phytotherapy in medieval Serbian medicine according to the pharmacological manuscripts of the Chilandar Medical Codex (15-16th centuries).

PubMed

Jarić, Snežana; Mitrović, Miroslava; Djurdjević, Lola; Kostić, Olga; Gajić, Gordana; Pavlović, Dragana; Pavlović, Pavle

2011-09-01

The Chilandar Medical Codex is the most significant and best preserved medieval Serbian manuscript and collects together documents on European medical science from the 12th to 15th centuries. It represents the best-known and most complete example of a large collection of medical manuscripts from the Salerno-Montpellier school, written in the vernacular - something which does not exist among the majority of European nations. This paper presents the section of the Codex that deals with phytotherapy, which is contained within the pharmacological manuscripts. An analysis of their contents shows that out of a total of 167 recorded substances, 135 are of plant origin (81%), 13 animal origin (7.7%) and 19 inorganic (11.3%). The recorded plant species are categorised into 63 families, of which the most frequent are: Apiaceae (8.1%), Lamiaceae (8.1%), Asteraceae (5.9%), Rosaceae (5.9%) and Fabaceae (4.4%). All possible plant parts were used in treatments: the whole plant (6%), underground parts (13.7% - root, rhizome, bulb) and aerial parts (80.3% - stem, leaf, flower, buds, fruit, seeds). Of the plants quoted, the following are mentioned most frequently: Vitis sp. (120), Rosa canina (55), Olea europaea (45), Pistacia lentiscus (25), Saccharum officinarum (23), Artemisia absinthium (16) and Foeniculum vulgare (15). The contents of the pharmacological manuscripts of the Chilandar Medical Codex point to the sound contemporary knowledge of the diversity of plant species, their origins, habitat types, the levels of their healing powers, and when and how to gather them and prepare them, as well as the recommended dose for the treatment of specific illnesses. As these manuscripts contain not only common, lay terms for the plants, but also scientific, botanical ones, we can consider them the precursor to Serbian botany. Based on its contents and the way in which they are presented, it can be viewed not only as the first Serbian pharmacopeia, but first Slavic pharmacopeia, too

The A2Πi˜X2Σ+ interaction in CO +: Deperturbation analyses of B- A and A- X bands of 12C 16O +, 13C 16O + and 14C 16O +

NASA Astrophysics Data System (ADS)

Coxon, John A.; Kępa, Ryszard; Piotrowska, Izabela

2010-08-01

The 1-0, 6-0 and 6-1 bands of the A2Πi→X2Σ+ system of 13C 16O + and the 2-0 and 2-1 bands of the A2Πi→X2Σ+ system of 14C 16O + have been recorded at high resolution for the first time. The 0-2 and 5-0 bands of the A → X system of 12C 16O + have also been recorded at higher resolution than in previous work. The spectra were excited in an air-cooled hollow cathode discharge and photographed using a 2-m plane grating spectrograph. The spectral resolution and the Doppler-broadened line widths are both ˜0.12 cm -1, and the experimental measurement precision of resolved lines is ˜0.02 cm -1. The measured line positions, sometimes in combination with literature data on the B2Σ+→A2Πi transition, have been employed in deperturbation analyses of level crossings in the near-degenerate A(0)˜ X(10) and A(5)˜ X(14) interactions in 12C 16O +, the A(1)˜ X(11) and A(6)˜ X(15) interactions in 13C 16O +, and the A(2)˜ X(12) interaction in 14C 16O +. No radial dependence of the electronic perturbation matrix elements HSO( r) and HRE( r) could be detected over the narrow range of r-centroids (1.477-1.501 Å), and the mean values of these parameters are HSO = -49.06(15) cm -1 and HRE = 0.211(2). Using iteratively improved RKR potentials and FC-overlap integrals, the mean HSO and HRE were employed in least-squares analyses of A → X literature data involving A( υ) levels of the three isotopologues that are affected by interactions with one or two distant X( υ∗) levels. The fitted parameters of the A2Πi state ( B υ, A υ, A Dυ, p υ, q υ) exhibit υ-dependences that are much smoother than those employing perturbed parameters determined in previous investigations. In addition, a significant electronic isotope effect has been characterized. The separations Te( A)- Te( X) of the minima of the A and X states of 13C 16O + and 14C 16O + are less than that of 12C 16O + by 0.39 and 0.73 cm -1, respectively. Although Born-Oppenheimer breakdown of this magnitude is

16 CFR § 1018.16 - Membership selection.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Membership selection. § 1018.16 Section Â... Establishment of Advisory Committees § 1018.16 Membership selection. (a) Whenever new applicants are required... Candidate Evaluation Panel, using selection criteria established by the Commission, shall evaluate all...

40 CFR 50.16 - National primary and secondary ambient air quality standards for lead.

Code of Federal Regulations, 2011 CFR

2011-07-01

... air quality standards for lead. 50.16 Section 50.16 Protection of Environment ENVIRONMENTAL PROTECTION... National primary and secondary ambient air quality standards for lead. (a) The national primary and secondary ambient air quality standards for lead (Pb) and its compounds are 0.15 micrograms per cubic meter...

16. Photographic copy of sepia of original construction drawing dated ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photographic copy of sepia of original construction drawing dated September 15, 1938 (original sepia in plan room of Base Civil Engineer, Scott AFB) Interior details - Scott Air Force Base, General Officer Quarters, 229 Birchard Street, O'Fallon, St. Clair County, IL

16. BUILDING NO. 445, PHYSICS LAB (FORMERLY GUN BAG LOADING), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. BUILDING NO. 445, PHYSICS LAB (FORMERLY GUN BAG LOADING), INTERIOR, SECOND LEVEL. LOOKING UP AT POWDER AND DISTRIBUTION TUBES. ELEVATOR SHAFT ON LEFT. - Picatinny Arsenal, 400 Area, Gun Bag Loading District, State Route 15 near I-80, Dover, Morris County, NJ

Cost-effectiveness of 12- and 15-year-old girls' human papillomavirus 16/18 population-based vaccination programmes in Lithuania.

PubMed

Vanagas, Giedrius; Padaiga, Zilvinas; Kurtinaitis, Juozas; Logminiene, Zeneta

2010-08-01

There is a large difference in the prevalence of cervical cancer between European countries. Between European Union countries, cervical cancer is the most prevalent in Lithuania. Currently we have available vaccines for different types of human papillomavirus virus (HPV), but we lack evidence on how the vaccination would be cost-effective in low-resource Eastern European countries like Lithuania. To create a simulation model for the Lithuanian population; to estimate epidemiological benefits and cost-effectiveness for a HPV16/18 vaccination programme in Lithuania. For the cost-effectiveness analysis, we used Lithuanian population mathematical simulation and epidemiological data modelling. We performed comparative analysis of annual vaccination programmes of 12-year-old or 15-year-old girls at different vaccine penetration levels. Lithuanian female population at all age groups. A vaccination programme in Lithuania would gain an average of 35.6 life years per death avoided. Vaccinated girls would experience up to 76.9% overall reduction in incidence of cervical cancers, 80.8% reduction in morbidity and 77.9% reduction in mortality over their lifetime. Cost per life year gained with different vaccine penetration levels would range from 2167.41 Euros to 2999.74 Euros. HPV vaccination in Lithuania would have a very positive impact on the epidemiological situation and it would be cost-effective at all ranges of vaccine penetration. Vaccination in Lithuania in the long term potentially could be more cost-effective due to avoiding early disease onset and lower accumulation of period costs.

10 CFR 436.15 - Formatting cost data.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Procedures for Life Cycle Cost Analyses § 436.15 Formatting cost data. In establishing cost data under §§ 436.16 and 436.17 and measuring cost effectiveness by the modes of analysis described by § 436.19 through... software referenced in the Life Cycle Cost Manual for the Federal Energy Management Program. ...

18 CFR 16.6 - Notification procedures under section 15 of the Federal Power Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... project is located, or (B) That has a population of 5,000 or more people and is located within 15 miles of... the Commission as required in paragraph (b) of this section at least five years, but no more than five... this section does not apply if a licensee filed notice more than five and one-half years before its...

PREFACE: 15th International Conference on the Strength of Materials (ICSMA-15)

NASA Astrophysics Data System (ADS)

Skrotzki, Werner; Oertel, Carl-Georg; Biermann, Horst; Heilmaier, Martin

2010-04-01

The 15th International Conference on the Strength of Materials (ICSMA 15) took place in Dresden, Germany, August 16-21, 2009. It belongs to the triennial series of ICSMA meetings with a long tradition, starting in 1967 - Tokyo, 1970 - Asilomar, 1973 - Cambridge, 1976 - Nancy, 1979 - Aachen, 1982 - Melbourne, 1985 - Montreal, 1988 - Tampere, 1991 - Haifa, 1994 - Sendai, 1997 - Prague, 2000 - Asilomar, 2003 - Budapest, 2006 - Xian. ICSMA 15 was hosted by the Dresden University of Technology, Institute of Structural Physics. Following the tradition of this conference series, it was the main focus of ICSMA 15 to promote and strengthen the fundamental understanding of the basic processes that govern the strength of materials. Nonetheless, it was the aim to forge links between basic research on model materials and applied research on engineering materials of technical importance. Thus, ICSMA 15 provided a forum for the presentation and discussion of research on the mechanical properties of all materials which are of interest to materials scientists and engineers from many different areas. The topics covered by ICSMA 15 were: 1.Atomistic and microstructural aspects of plastic deformation 2.Atomistic and microstructural aspects of fracture 3.Adhesion and interfacial strength 4.Cyclic deformation and fatigue 5.High temperature deformation and creep 6.Mechanical properties related to phase transformations 7.Large and severe plastic deformation 8.Nano- and microscale phenomena in plasticity and fracture 9.Strength issues in biological systems and biomaterials 10.Mechanical behaviour of glasses and non-crystalline solids 11.Multiscale modelling and experimental validation 12.Insight through new experimental methods 13.Other new developments related to the field While there was large interest in the new topics 7 and 8, contributions to topic 9 were much less than expected. ICSMA 15 attracted 352 scientists from 30 countries with one fourth of the participants being students

Early Observations of the Type Ia Supernova iPTF 16abc

NASA Astrophysics Data System (ADS)

Miller, Adam; iPTF Collaboration

2018-01-01

Early observations of Type Ia supernovae (SNe) provide a unique probe of their progenitor systems and explosion physics. Here, we report the intermediate Palomar Transient Factory (iPTF) discovery of an extraordinarily young SN Ia, iPTF 16abc. By fitting a power law to our early light curve, we infer that first light for the SN only occurred 0.15 +0.15-0.07 d before our first detection. In the ~24 hr after discovery, iPTF 16abc rose by ~2 mag, following a near-linear rise in flux for ~3 d. Strong C II absorption is detected in the early spectra of iPTF 16abc, before disappearing after ~7 d. Unlike the extensively-observed Type Ia SN 2011fe, the (B-V)_0 colors of iPTF 16abc are blue and nearly constant in the days after explosion. We show that our early observations of iPTF 16abc cannot be explained by either SN shock breakout and the associated, subsequent cooling, or the SN ejecta colliding with a stellar companion. Instead, we argue that the early characteristics of iPTF 16abc, including: (i) the rapid, near-linear rise, (ii) the non-evolving blue colors, and (iii) the strong absorption from ionized carbon, are the result of either vigorous mixing of radioactive-Ni in the SN ejecta, or ejecta interaction with diffuse material, or a combination of the two. In the next few years, dozens of very young normal SNe Ia will be discovered, and observations similar to those presented here will constrain the white dwarf explosion mechanism.

Selected Proceedings ADPA (American Defense Preparedness Association) Conference: Industrial Base Planning Issues ’Industrial Preparedness Initiatives in the New Budget Scenario’ Held at Washington, DC on March 15-16 1984,

DTIC Science & Technology

1984-03-16

Washington, D.C. ,y lC N:..-,., ~~ AR 1 5 S :.,. March 15-16, 1984 A 6 ;4 C 3 4 H 040 PRESENTATION ON DOD INDUSTRIAL RESPONSIVENESS SIMULATION ADPA...the early days of the Korean War and has served the country well in meeting crisis situations since then. Prominently at stake in the coming days are ...oceans are 367 Soviet submarines, according to the U.S. Navy, and there is no assurance that sealanes will not be seriously threatened. * Speaking of "nuts

Dithallium(III)-Containing 30-Tungsto-4-phosphate, [Tl2Na2(H2O)2(P2W15O56)2]16-: Synthesis, Structural Characterization, and Biological Studies.

PubMed

Ayass, Wassim W; Fodor, Tamás; Farkas, Edit; Lin, Zhengguo; Qasim, Hafiz M; Bhattacharya, Saurav; Mougharbel, Ali S; Abdallah, Khaled; Ullrich, Matthias S; Zaib, Sumera; Iqbal, Jamshed; Harangi, Sándor; Szalontai, Gábor; Bányai, István; Zékány, László; Tóth, Imre; Kortz, Ulrich

2018-06-18

Here we report on the synthesis and structural characterization of the dithallium(III)-containing 30-tungsto -4-phosphate [Tl 2 Na 2 (H 2 O) 2 {P 2 W 15 O 56 } 2 ] 16- (1) by a multitude of solid-state and solution techniques. Polyanion 1 comprises two octahedrally coordinated Tl 3+ ions sandwiched between two trilacunary {P 2 W 15 } Wells-Dawson fragments and represents only the second structurally characterized, discrete thallium-containing polyoxometalate to date. The two outer positions of the central rhombus are occupied by sodium ions. The title polyanion is solution-stable as shown by 31 P and 203/205 Tl NMR. This was also supported by Tl NMR spectra simulations including several spin systems of isotopologues with half-spin nuclei ( 203 Tl, 205 Tl, 31 P, 183 W). 23 Na NMR showed a time-averaged signal of the Na + counter cations and the structurally bonded Na + ions. 203/205 Tl NMR spectra also showed a minor signal tentatively attributed to the trithallium-containing derivative [Tl 3 Na(H 2 O) 2 (P 2 W 15 O 56 ) 2 ] 14- , which could also be identified in the solid state by single-crystal X-ray diffraction. The bioactivity of polyanion 1 was also tested against bacteria and Leishmania.

Health and cancer prevention: implications of the knowledge and beliefs of 15-16 year old school pupils in South Africa.

PubMed

Walker, A R; Walker, B F; Jerling, J; Rossouw, K; Lelake, A

1999-06-01

The objective was to collect information from African and white pupils aged 15-16 years on their knowledge of and attitudes towards cancer, and their understanding of health-related behaviours in relation to their future experience. Questionnaires were completed by a series of 338 African and 378 white pupils in suburban secondary schools. African and white pupils knew most about lung cancer, and had some knowledge of skin and breast cancers. Smoking was seen by most as the chief cause of the disease. Half of both groups perceived a high intake of vegetables and fruit as protective. Television and printed media were the most important sources of information. The children in both groups were more anxious about unemployment and violence, and also, among African children, about AIDS, than about future ill-health. Thus, health was not perceived by many as the most important goal in life. Discussion indicates that white adolescents and also white adults, with more advanced understanding of cancer causation, make very limited use of their knowledge, dietary and non-dietary, to avoid the disease. In brief, level of cancer knowledge has very limited implications. Although young Africans in the course of their transition are very unlikely to seek to diminish their risk of cancer, there must be no lessening of urgent warnings and advice through the media on the avoidance of the disease.

16. FOREGROUND (LEFT TO RIGHT) EXHAUST AND INTAKE DUCTS. SOUTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. FOREGROUND (LEFT TO RIGHT) EXHAUST AND INTAKE DUCTS. SOUTH SIDE AND WEST FRONT OF LAUNCH CONTROL SUPPORT BUILDING IN BACKGROUND. VIEW TO NORTH. - Minuteman III ICBM Launch Control Facility November-1, 1.5 miles North of New Raymer & State Highway 14, New Raymer, Weld County, CO

Performance of mixed pine-hardwood stands 16 years after fell-and-burn treatments

Treesearch

Elizabeth M. Blizzard; David H. van Lear; G. Geoff Wang; Thomas A. Waldrop

2006-01-01

Four variations of the fell-and-burn technique were compared for height and volume production on dry Piedmont sites. A two-factorial randomized complete block design of winter versus spring felling, with and without a summer burn, was implemented, followed by planting of loblolly pine (Pinus taeda L.) at 15 x 15 foot spacing. After 16 growing seasons...

Ultraviolet photoelectron spectroscopy reveals energy-band dispersion for π-stacked 7,8,15,16-tetraazaterrylene thin films in a donor-acceptor bulk heterojunction.

PubMed

Aghdassi, Nabi; Wang, Qi; Ji, Ru-Ru; Wang, Bin; Fan, Jian; Duhm, Steffen

2018-05-11

7,8,15,16-tetraazaterrylene (TAT) thin films grown on highly oriented pyrolytic graphite (HOPG) substrates were studied extensively with regard to their intrinsic and interfacial electronic properties by means of ultraviolet photoelectron spectroscopy (UPS). Merely weak substrate-adsorbate interaction occurs at the TAT/HOPG interface, with interface energetics being only little affected by the nominal film thickness. Photon energy-dependent UPS performed perpendicular to the molecular planes of TAT multilayer films at room temperature clearly reveals band-like intermolecular dispersion of the TAT highest occupied molecular orbital (HOMO) energy. Based on a comparison with a tight-binding model, a relatively narrow bandwidth of 54 meV is derived, which points to the presence of an intermediate regime between hopping and band-like hole transport. Upon additional deposition of 2,2':5',2″:5″,2″'-quaterthiophene (4T), a 4T:TAT donor-acceptor bulk heterojunction with a considerable HOMO-level offset at the donor-acceptor interface is formed. The 4T:TAT bulk heterojunction likewise exhibits intermolecular dispersion of the TAT HOMO energy, yet with a significant decreased bandwidth.

What Are the Barriers Which Discourage 15-16 Year-Old Girls from Participating in Team Sports and How Can We Overcome Them?

PubMed Central

Wetton, Abigail R.; Jones, Angela R.; Pearce, Mark S.

2013-01-01

Given the clear benefits of regular physical activity (such as reduced risks of cardiovascular disease and obesity, as well as other benefits including those related to mental health), exploration of the reasons that adolescent girls give for not taking part in team sports may be particularly valuable for enhancing later rates of participation. We combined questionnaires (n = 60) and semistructured interviews (n = 6) to assess the barriers that prevent 15-16-year-old girls from participating in extracurricular team games and what can be done to overcome these barriers and improve physical activity levels. Four barriers became prominent as to why girls in this sample do not participate: Internal Factors, Existing Stereotypes, Other Hobbies and Teachers. Methods to overcome these barriers were identified; changing teachers' attitudes and shifting the media's focus away from male sport. Following the successful summer Olympics and Paralympics in the UK, and the resulting positive focus on some of the nation's female athletes, a shift in focus may be possible. However, this needs to be maintained to allow girls more opportunities, role models and motivation to participate in sport. PMID:24073416

16 CFR § 1211.12 - Requirements for edge sensors.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Requirements for edge sensors. § 1211.12... Requirements for edge sensors. (a) Normal operation test. (1) When installed on a representative door edge, an edge sensor shall actuate upon the application of a 15 pounds (66.7 N) or less force in the direction...

16 CFR 16.10 - Minutes and transcripts of meetings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Minutes and transcripts of meetings. 16.10 Section 16.10 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.10 Minutes and transcripts of meetings. (a) Detailed minutes of each...

Characterizing Enterovirus 71 and Coxsackievirus A16 virus-like particles production in insect cells.

PubMed

Somasundaram, Balaji; Chang, Cindy; Fan, Yuan Y; Lim, Pei-Yin; Cardosa, Jane; Lua, Linda

2016-02-15

Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are two viruses commonly responsible for hand, foot and mouth disease (HFMD) in children. The lack of prophylactic or therapeutic measures against HFMD is a major public health concern. Insect cell-based EV71 and CVA16 virus-like particles (VLPs) are promising vaccine candidates against HFMD and are currently under development. In this paper, the influence of insect cell line, incubation temperature, and serial passaging effect and stability of budded virus (BV) stocks on EV71 and CVA16 VLP production was investigated. Enhanced EV71 and CVA16 VLP production was observed in Sf9 cells compared to High Five™ cells. Lowering the incubation temperature from the standard 27°C to 21°C increased the production of both VLPs in Sf9 cells. Serial passaging of CVA16 BV stocks in cell culture had a detrimental effect on the productivity of the structural proteins and the effect was observed with only 5 passages of BV stocks. A 2.7× higher production yield was achieved with EV71 compared to CVA16. High-resolution asymmetric flow field-flow fractionation couple with multi-angle light scattering (AF4-MALS) was used for the first time to characterize EV71 and CVA16 VLPs, displaying an average root mean square radius of 15±1nm and 15.3±5.8 nm respectively. This study highlights the need for different approaches in the design of production process to develop a bivalent EV71 and CVA16 vaccine. Copyright © 2015 Elsevier Inc. All rights reserved.

Loss of Mammal-specific Tectorial Membrane Component Carcinoembryonic Antigen Cell Adhesion Molecule 16 (CEACAM16) Leads to Hearing Impairment at Low and High Frequencies*

PubMed Central

Kammerer, Robert; Rüttiger, Lukas; Riesenberg, Rainer; Schäuble, Constanze; Krupar, Rosemarie; Kamp, Annegret; Sunami, Kishiko; Eisenried, Andreas; Hennenberg, Martin; Grunert, Fritz; Bress, Andreas; Battaglia, Sebastiano; Schrewe, Heinrich; Knipper, Marlies; Schneider, Marlon R.; Zimmermann, Wolfgang

2012-01-01

The vertebrate-restricted carcinoembryonic antigen gene family evolves extremely rapidly. Among their widely expressed members, the mammal-specific, secreted CEACAM16 is exceptionally well conserved and specifically expressed in the inner ear. To elucidate a potential auditory function, we inactivated murine Ceacam16 by homologous recombination. In young Ceacam16−/− mice the hearing threshold for frequencies below 10 kHz and above 22 kHz was raised. This hearing impairment progressed with age. A similar phenotype is observed in hearing-impaired members of Family 1070 with non-syndromic autosomal dominant hearing loss (DFNA4) who carry a missense mutation in CEACAM16. CEACAM16 was found in interdental and Deiters cells and was deposited in the tectorial membrane of the cochlea between postnatal days 12 and 15, when hearing starts in mice. In cochlear sections of Ceacam16−/− mice tectorial membranes were significantly more often stretched out as compared with wild-type mice where they were mostly contracted and detached from the outer hair cells. Homotypic cell sorting observed after ectopic cell surface expression of the carboxyl-terminal immunoglobulin variable-like N2 domain of CEACAM16 indicated that CEACAM16 can interact in trans. Furthermore, Western blot analyses of CEACAM16 under reducing and non-reducing conditions demonstrated oligomerization via unpaired cysteines. Taken together, CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as α-tectorin and β-tectorin and influences the physical properties of the tectorial membrane. Evolution of CEACAM16 might have been an important step for the specialization of the mammalian cochlea, allowing hearing over an extended frequency range. PMID:22544735

Calibration of the NASA Glenn Research Center 16 in. Mass-Flow Plug

NASA Technical Reports Server (NTRS)

Davis, David O.; Friedlander, David J.; Saunders, J. David; Frate, Franco C.; Foster, Lancert E.

2014-01-01

The results of an experimental calibration of the NASA Glenn Research Center 16 in. Mass-Flow Plug (MFP) are presented and compared to a previously obtained calibration of a 15 in. Mass-Flow Plug. An ASME low-beta, long-radius nozzle was used as the calibration reference. The discharge coefficient for the ASME nozzle was obtained by numerically simulating the flow through the nozzle from the WIND-US code. The results showed agreement between the 15 and 16 in. MFPs for area ratios (MFP to pipe area ratio) greater than 0.6 but deviate at area ratios below this value for reasons that are not fully understood. A general uncertainty analysis was also performed and indicates that large uncertainties in the calibration are present for low MFP area ratios.

83. Photographic copy of historic photo, December 16, 1929 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. Photographic copy of historic photo, December 16, 1929 (original print filed in Record Group 115, National Archives, Washington, D.C.). OWYHEE DAM-LOOKING DOWNSTREAM FROM UPPER COFFERDAM (POINT #15) SHOWING CREVICE AND KEYWAY CUTOFF; ALSO CABLEWAY CONTROL HOUSE AND ENTRANCE ADIT. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

A 16 deg2 survey of emission-line galaxies at z < 1.5 in HSC-SSP Public Data Release 1

NASA Astrophysics Data System (ADS)

Hayashi, Masao; Tanaka, Masayuki; Shimakawa, Rhythm; Furusawa, Hisanori; Momose, Rieko; Koyama, Yusei; Silverman, John D.; Kodama, Tadayuki; Komiyama, Yutaka; Leauthaud, Alexie; Lin, Yen-Ting; Miyazaki, Satoshi; Nagao, Tohru; Nishizawa, Atsushi J.; Ouchi, Masami; Shibuya, Takatoshi; Tadaki, Ken-ichi; Yabe, Kiyoto

2018-01-01

We present initial results from the Subaru Strategic Program (SSP) with Hyper Suprime-Cam (HSC) on a comprehensive survey of emission-line galaxies at z < 1.5 based on narrowband imaging. The first Public Data Release provides us with data from two narrowband filters, specifically NB816 and NB921 over 5.7 deg2 and 16.2 deg2 respectively. The 5 σ limiting magnitudes are 25.2 mag (UltraDeep layer, 1.4 deg2) and 24.8 mag (Deep layer, 4.3 deg2) for NB816, and 25.1 mag (UltraDeep, 2.9 deg2) and 24.6-24.8 mag (Deep, 13.3 deg2) for NB921. The wide-field imaging allows us to construct unprecedentedly large samples of 8054 H α emitters at z ≈ 0.25 and 0.40, 8656 [O III] emitters at z ≈ 0.63 and 0.84, and 16877 [O II] emitters at z ≈ 1.19 and 1.47. We map the cosmic web on scales out to about 50 comoving Mpc that includes galaxy clusters, identified by red sequence galaxies, located at the intersection of filamentary structures of star-forming galaxies. The luminosity functions of emission-line galaxies are measured with precision and are consistent with published studies. The wide field coverage of the data enables us to measure the luminosity functions up to brighter luminosities than previous studies. The comparison of the luminosity functions between the different HSC-SSP fields suggests that a survey volume of >5 × 105 Mpc3 is essential to overcome cosmic variance. Since the current data have not reached the full depth expected for the HSC-SSP, the color cut in i - NB816 or z - NB921 induces a bias towards star-forming galaxies with large equivalent widths, primarily seen in the stellar mass functions for the H α emitters at z ≈ 0.25-0.40. Even so, the emission-line galaxies clearly cover a wide range of luminosity, stellar mass, and environment, thus demonstrating the usefulness of the narrowband data from the HSC-SSP for investigating star-forming galaxies at z < 1.5.

[Analysis of genetic polymorphism in randomized donor's HPA 1-16 antigens and establishment of typed platelet donor data bank].

PubMed

Sun, Guo-Dong; Duan, Xian-Min; Zhang, Yan-Ping; Yin, Zhi-Zhu; Niu, Xiao-Li; Li, Yan-Feng; Niu, Hai-Jiang; Zhao, You-Liang

2005-10-01

To study the genetic polymorphism of HPA 1-16 platelet antigen alleles among unrelated volunteer donors and establish a typed platelet donor panel in Handan, typing was perfomed by polymerase chain reaction using sequence-specific primers (SSP-PCR); 148 random unrelated blood donors in Handan were genotyped for each of the HPA 1-16 antigen. The gene frequencies were analyzed and the genetype frequencies were determined by direct counting, and these data were compared with HPA distribution among various population by the chi-square test. The results indicated that HPA-1a, 2a, 4a-14a, 16a genes were found among the 16 HPAs in every sample tested. Monomorphic HPA-4a, 7a-14a, 16a were found in the samples. For HPA-1, 2, 5 and 6, a/a homozygosity was predominant with frequencies of 0.9595, 0.8108, 0.9865, 0.9797, respectively, and none of HPA b/b was found in the samples. HPA-1b, 2b, 5b, 6b were rarely found among subjects. HPA-15 had the greatest heterozygosity with a gene frequency of 0.2230, 0.5270, 0.2500 for HPA15a/15a, HPA15a/15b, HPA15b/15b, respectively. HPA-3 showed the second greatest heterozygosity with a gene frequency of 0.3851, 0.5135, 0.1014 for HPA3a/3a, HPA3a/3b, HPA3b/3b, respectively. HPA genotype frequencies showed a good fit to Hardy-Weinberg equilibrium. HPA1-5 gene frequencies for Chinese people in Handan were consistent with those of Chinese people in Shijiazhuang (P > 0.05). Among the HPA1-13, -15, the frequencies of HPA-1, -2, -6 for Chinese people in Handan differed appreciably from those for Chinese people in Taiwan (P < 0.05), others were similar to those of Chinese people in Taiwan. Among the HPA 1 - 8, a similarity was noted between Chinese people in Handan and Koreans (P > 0.05), except for HPA-3. Frequencies of HPA-1, -2, -5 significantly were differed from those in African Americans, as compared with HPA 1-5 (P < 0.05). Comparison of gene frequencies from HPA-1 and -5 showed significant differences between Chinese people in Handan and

12. "TEST STANDS NOS. 11, 13, & 15; CONCRETE STRUCTURAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. "TEST STANDS NOS. 1-1, 1-3, & 1-5; CONCRETE STRUCTURAL SECTIONS AND DETAILS." Specifications No. OC12-50-10; Drawing No. 60-09-06; no sheet number within title block. D.O. SERIES 1109/16, Rev. E. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract DA-04353 Eng. 177, Rev. E; Date: 26 Dec. 1951. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-5, Test Area 1-115, northwest end of Saturn Boulevard, Boron, Kern County, CA

Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides

PubMed Central

Ikeda, Akemi; Kojima-Aikawa, Kyoko; Taniguchi, Naoyuki; Varón Silva, Daniel; Feizi, Ten; Seeberger, Peter H.; Yamaguchi, Yoshiki

2018-01-01

ZG16p is a soluble mammalian lectin that interacts with mannose and heparan sulfate. Here we describe detailed analyses of the interactions of human ZG16p with mycobacterial phosphatidylinositol mannosides (PIMs), using glycan microarray and NMR. Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p. Saturation Transfer Difference (STD) NMR and transferred NOE experiments with chemically synthesized PIM glycans indicate that PIMs preferentially interacts with ZG16p using the mannose residues. Binding site of PIMs is identified by chemical shift perturbation experiments using uniformly 15N-labeled ZG16p. NMR results with docking simulations suggest a binding mode of ZG16p and PIM glycan, which would help to consider the physiological role of ZG16p. PMID:25919894

Polar ionosphere of Venus near the planet's terminator according to radio-occultation data from the Venera 15 and 16 satellites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savich, N.A.; Andrev, V.E.

1986-11-01

The Venera-15 and -16 satellites, using the method of dual-frequency radio transillumination, determined the altitude distribution of electron concentration over the surface of Venus in the planet's polar regions near its terminator for solar zenith angles of 90 less than or equal to /ZETA/theta less than or equal to 96/sup 0/. The measurements were conducted from October 25 through November 5, 1983, in a period of comparatively low solar activity. In the experiments, the on-board transmitter emitted two coherent signals in the decimeter and centimeter bands at the times of the satellites' settings or occultations behind the planetary disk andmore » of their emerging from behind it, and the terrestrial receiver complex carried out measurements of the phase and frequency differences of these signals. It was found that, at 92 < /ZETA//PHI/ < 96/sup 0/, the distribution of electron concentration can have either one or two ionization maxima. The concentration at the upper maximum, situated at altitudes of 140-150 km, decreases regularly with increase of /ZETA/theta, while at the lower maximum it is practically independent of /ZETA/theta. The altitude range of the ionosphere in the vicinity of the terminator is as much as 10/sup 3/ km. At altitudes h > 200 km a plasma layer forms with an almost constant electron concentration of about 10/sup 3/ cm/sup -3/.« less

16. Detail of rachet mechanisms on west wall of South ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Detail of rachet mechanisms on west wall of South Section. These rachets were need in operating the ship blocking mechanism that was installed in 1946 along with the chain rack alots shown in photo WA-116-E-15. - Puget Sound Naval Shipyard, Drydock No. 3, Farragut Avenue, Bremerton, Kitsap County, WA

Complete Measurement of Stable Isotopes in N2O (δ15N, δ15Nα, δ15Nβ, δ18O, δ17O) Using Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS)

NASA Astrophysics Data System (ADS)

Leen, J. B.; Gupta, M.

2014-12-01

Nitrate contamination in water is a worldwide environmental problem and source apportionment is critical to managing nitrate pollution. Fractionation caused by physical, chemical and biological processes alters the isotope ratios of nitrates (15N/14N, 18O/16O and 17O/16O) and biochemical nitrification and denitrification impart different intramolecular site preference (15N14NO vs. 14N15NO). Additionally, atmospheric nitrate is anomalously enriched in 17O compared to other nitrate sources. The anomaly (Δ17O) is conserved during fractionation processes, providing a tracer of atmospheric nitrate. All of these effects can be used to apportion nitrate in soil. Current technology for measuring nitrate isotopes is complicated and costly - it involves conversion of nitrate to nitrous oxide (N2O), purification, preconcentration and measurement by isotope ratio mass spectrometer (IRMS). Site specific measurements require a custom IRMS. There is a pressing need to make this measurement simpler and more accessible. Los Gatos Research has developed a next generation mid-infrared Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS) analyzer to quantify all stable isotope ratios of N2O (δ15N, δ15Nα, δ15Nβ, δ18O, δ17O). We present the latest performance data demonstrating the precision and accuracy of the OA-ICOS based measurement. At an N2O concentration of 322 ppb, the analyzer quantifies [N2O], δ15N, δ15Na, δ15Nb, and δ18O with a precision of ±0.05 ppb, ±0.4 ‰, ±0.45 ‰, and ±0.6 ‰, and ±0.8 ‰ respectively (1σ, 100s; 1σ, 1000s for δ18O). Measurements of gas standards demonstrate accuracy better than ±1 ‰ for isotope ratios over a wide dynamic range (200 - 100,000 ppb). The measurement of δ17O requires a higher concentration (1 - 50 ppm), easily obtainable through conversion of nitrates in water. For 10 ppm of N2O, the instrument achieves a δ17O precision of ±0.05 ‰ (1σ, 1000s). This performance is sufficient to quantify atmospheric

Report of the M16 Rifle Review Panel. Volume 6, Appendix 5. Procurement, Production, and Distribution History of the AR15-M16-M16A1 Weapon System

DTIC Science & Technology

1968-06-01

procurement of 19,000 new rifles and 1.9 million rounds of 5.56mm am:nunition ;Jere requested in the Air Force 1962 budget. The Department of Defense at...the Department of Defense inventories was not desirable. Air Force Histcry of the ARIS Rifle (Mid-1960 tc Yid- 1962 ), undated. Adoption of a .223 caliber...discussions on the Air Force procurement.3/ Final Congressional authorization for the Air Force procurement was granted 15 May 1962 . The 8,500 rifles

Localized Deformation Beginning more than 15 km Beneath the Mid-Atlantic Ridge, 14 to 16 N

NASA Astrophysics Data System (ADS)

Kelemen, P.

2003-12-01

ODP Leg 209 drilled 19 holes at 8 sites along the Mid-Atlantic Ridge from 14° 43 to 15° N. All sites were surveyed by submersible, and chosen to be < 200 m from peridotite or dunite exposed on the seafloor; outcrops of gabbroic rock were also close to some sites. One of our primary goals was to constrain the mechanism of mantle upwelling, corner flow and exhumation of shallow mantle rocks. Drilling at Sites 1268, 1270-72, 1274 and 1275 penetrated 1075 meters, and recovered 354 m of core. At Sites 1268 and 1270-72 we recovered 25% gabbroic rocks and 75% residual mantle peridotite. Core from Site 1274 was mainly residual peridotite, while core from Site 1275 was mainly gabbroic. Most of the residual peridotites have nearly undeformed, protogranular textures. Orthopyroxenes are interstitial to olivine or even poikilitic. Rare, isolated clinopyroxene grains are also interstitial. Skeletal spinel grains have mm-scale extensions in three dimensions, with no discernable shape fabric. These textures are clearly different from porphyroclastic textures typical in ophiolites and fracture zone dredges. As described elsewhere at this meeting, impregnated peridotites contain olivine, 2 pyroxenes, plagioclase and spinel, and equilibrated at 0.54 GPa (+/-0.14 GPa, 2σ ) and 1220° C (+/-16° C, 2σ ) [Kinzler & Grove, JGR 92]. Melts entered the thermal boundary layer beneath the Mid-Atlantic Ridge at about 20 km [e.g., Sleep, JGR 75; Reid & Jackson, MGR 82; Grove et al JGR 92; Cannat JGR 96; Michael & Chase CMP 97; Braun et al., EPSL 00], and began to crystallize within impregnated peridotites and as discrete plutons intruding peridotite. Gabbroic rocks and peridotites from most sites underwent large tectonic rotations since aquiring remanent magnetization. At some sites, rotations may have exceeded 60° around near-horizontal axes parallel to the Mid-Atlantic Ridge. Such large rotations are unlikely to have been accomodated along a single fault, and instead blocks were

Petrologic variations in Apollo 16 surface soils

NASA Technical Reports Server (NTRS)

Houck, K. J.

1982-01-01

Source rock, maturation history and intrasite variation data are derived for the Apollo 16 regolith by comparing modal analyses of 15 surface soils with rake and rock sample data. Triangular source rock component plots show that Apollo 16 soils have similar source rocks that are well homogenized throughout the site. The site can be divided into three soil petrographic provinces. Central site soils are mature, well homogenized, and enriched in glass. They are probably the most typical Cayley Plains materials present. North Ray soils are immature to submature, containing North Ray ejecta. South Ray soils are mature, but contain small amounts of fresh impact melts and plagioclase, due perhaps to the breakdown of blocky South Ray ejecta. The different compositions and physical properties of North and South Ray ejecta support the hypothesis that the latter event excavated Cayley material, while the former excavated Descartes materials.

Risk of spontaneous abortion and other pregnancy outcomes in 15-25 year old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom.

PubMed

Baril, Laurence; Rosillon, Dominique; Willame, Corinne; Angelo, Maria Genalin; Zima, Julia; van den Bosch, Judith H; Van Staa, Tjeerd; Boggon, Rachael; Bunge, Eveline M; Hernandez-Diaz, Sonia; Chambers, Christina D

2015-11-27

We assessed the risk of spontaneous abortion (SA) after inadvertent exposure to HPV-16/18-vaccine during pregnancy using an observational cohort design. The study population included women aged 15-25 years registered with the Clinical Practice Research Datalink General Practice OnLine Database in the United Kingdom (UK), who received at least one HPV-16/18-vaccine dose between 1st September 2008 and 30th June 2011. Exposed women had the first day of gestation between 30 days before and 45 days (90 days for the extended exposure period) after any HPV-16/18-vaccine dose. Non-exposed women had the first day of gestation 120 days-18 months after the last dose. SA defined as foetal loss between weeks 1 and 23 of gestation (UK definition). The frequency of SA was 11.6% (among 207 exposed) and 9.0% (632 non-exposed), women: hazard ratio (HR) adjusted for age at first day of gestation 1.30 (95% confidence interval: 0.79-2.12). Sensitivity analysis per number of doses administered (-30 to +45-day risk period) showed a HR for SA of 1.11 (0.64-1.91) for 18/178 women with one dose during the risk period versus 2.55 (1.09-5.93) in 6/29 women with two doses within a 4-5 weeks period. The proportion of pre-term/full-term/postterm deliveries, small/large for gestational age infants, and birth defects was not significantly different between exposed and non-exposed women. Results were consistent using a (United States) SA definition of foetal loss between weeks 1-19 and/or the extended risk period. There was no evidence of an increased risk of SA and other adverse pregnancy outcomes in young women inadvertently HPV-16/18-vaccinated around gestation. Nevertheless, women who are pregnant or trying to become pregnant are advised to postpone vaccination until completion of pregnancy. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Assessing mycoplasma contamination of cell cultures by qPCR using a set of universal primer pairs targeting a 1.5 kb fragment of 16S rRNA genes

PubMed Central

Jean, Audrey; Tardy, Florence; Allatif, Omran; Grosjean, Isabelle; Blanquier, Bariza

2017-01-01

Mycoplasmas (a generic name for Mollicutes) are a predominant bacterial contaminant of cell culture and cell derived products including viruses. This prokaryote class is characterized by very small size and lack of a cell wall. Consequently, mycoplasmas escape ultrafiltration and visualization under routine microscopic examination, hence the ease with which cells in culture can be contaminated, with routinely more than 10% of cell lines being contaminated. Mycoplasma are a formidable threat both in fundamental research by perverting a whole range of cell properties and functions and in the pharmacological use of cells and cell derived products. Although many methods have been developed, there is still a need for a sensitive, universal assay. Here is reported the development and validation of a quantitative polymerase chain reaction (qPCR) based on the amplification of a 1.5 kb fragment covering the 16S rDNA of the Mollicute class by real-time PCR using universal U1 and U8 degenerate primers. The method includes the addition of a DNA loading probe to each sample to monitor DNA extraction and the absence of PCR inhibitors in the extracted DNA, a positive mycoplasma 16S rDNA traceable reference sample to exclude any accidental contamination of an unknown sample with this reference DNA, an analysis procedure based on the examination of the melting curve and the size of the PCR amplicon, followed by quantification of the number of 16S rDNA copies (with a lower limit of 19 copies) when relevant, and, if useful, the identification of the contaminating prokaryote by sequencing. The method was validated on a collection of mycoplasma strains and by testing over 100 samples of unknown contamination status including stocks of viruses requiring biosafety level 2, 3 or 4 containments. When compared to four established methods, the m16S_qPCR technique exhibits the highest sensitivity in detecting mycoplasma contamination. PMID:28225826

Enhanced hypervelocity launcher: Capabilities to 16 km/s

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chhabildas, L.C.; Kmetyk, L.N.; Reinhart, W.D.

1993-12-31

A systematic study is described which has led to the successful launch of thin flier plates to velocities of 16 km/s. The energy required to launch a flier plant to 16 km/s is approximately 10 to 15 times the energy required to melt and vaporize the plate. The energy must, therefore, be deposited in a well-controlled manner to prevent melt or vaporation. This is achieved by using a graded-density assembly to impact a stationary flier-plate upon impact time dependent, structure, high pressure pulses are generated and used to propel the plantes plates to hypervelocities without melt or fracture. In previousmore » studies, a graded density impact of 7.3 km/s was used to launch a 0.5 mm thick plate to a velocity of over 12 km/s. If impact techniques alone were to be used to achieve flier-plate velocities approaching 16 km/s, this would require that the graded-density impact occur at {approximately} 10 km/s. In this paper, we describe a new technique that has been implemented to enhance the performance of the Sandia hypervelocity launcher. This technique of creating an impact-generated acceleration reservoir, has allowed the launch of 0.5 mm to 1.0 mm thick plates to record velocities up to 15.8 km/s. In these experiments, both titanium (Ti-6A1-4V) and aluminum (6061-T6) alloy were used for the flier-plate material. These are the highest metallic projectile plate velocities ever achieved for masses in the range of 0.1 g to 1 g.« less

15 CFR 4a.5 - Duration of classification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Duration of classification. 4a.5 Section 4a.5 Commerce and Foreign Trade Office of the Secretary of Commerce CLASSIFICATION..., except as provided in § 1.6(d) of E.O. 12958. Under E.O. 12958, information may be exempted from...

15 CFR 4a.5 - Duration of classification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Duration of classification. 4a.5 Section 4a.5 Commerce and Foreign Trade Office of the Secretary of Commerce CLASSIFICATION..., except as provided in § 1.6(d) of E.O. 12958. Under E.O. 12958, information may be exempted from...

15 CFR 4a.5 - Duration of classification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Duration of classification. 4a.5 Section 4a.5 Commerce and Foreign Trade Office of the Secretary of Commerce CLASSIFICATION..., except as provided in § 1.6(d) of E.O. 12958. Under E.O. 12958, information may be exempted from...

15 CFR 4a.5 - Duration of classification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Duration of classification. 4a.5 Section 4a.5 Commerce and Foreign Trade Office of the Secretary of Commerce CLASSIFICATION..., except as provided in § 1.6(d) of E.O. 12958. Under E.O. 12958, information may be exempted from...

Expansion of antimonato polyoxovanadates with transition metal complexes: (Co(N3C5H15)2)2[{Co(N3C5H15)2}V15Sb6O42(H2O)]·5H2O and (Ni(N3C5H15)2)2[{Ni(N3C5H15)2}V15Sb6O42(H2O)]·8H2O.

PubMed

Antonova, Elena; Näther, Christian; Kögerler, Paul; Bensch, Wolfgang

2012-02-20

Two new polyoxovanadates (Co(N(3)C(5)H(15))(2))(2)[{Co(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)]·5H(2)O (1) and (Ni(N(3)C(5)H(15))(2))(2)[{Ni(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)]·8H(2)O (2) (N(3)C(5)H(15) = N-(2-aminoethyl)-1,3-propanediamine) were synthesized under solvothermal conditions and structurally characterized. In both structures the [V(15)Sb(6)O(42)(H(2)O)](6-) shell displays the main structural motif, which is strongly related to the {V(18)O(42)} archetype cluster. Both compounds crystallize in the triclinic space group P1 with a = 14.3438(4), b = 16.6471(6), c = 18.9186(6) Å, α = 87.291(3)°, β = 83.340(3)°, γ = 78.890(3)°, and V = 4401.4(2) Å(3) (1) and a = 14.5697(13), b = 15.8523(16), c = 20.2411(18) Å, α = 86.702(11)°, β = 84.957(11)°, γ = 76.941(11)°, and V = 4533.0(7) Å(3) (2). In the structure of 1 the [V(15)Sb(6)O(42)(H(2)O)](6-) cluster anion is bound to a [Co(N(3)C(5)H(15))(2)](2+) complex via a terminal oxygen atom. In the Co(2+)-centered complex, one of the amine ligands coordinates in tridentate mode and the second one in bidentate mode to form a strongly distorted CoN(5)O octahedron. Similarly, in compound 2 an analogous NiN(5)O complex is joined to the [V(15)Sb(6)O(42)(H(2)O)](6-) anion via the same attachment mode. A remarkable difference between the two compounds is the orientation of the noncoordinated propylamine group leading to intermolecular Sb···O contacts in 1 and to Sb···N interactions in 2. In the solid-state lattices of 1 and 2, two additional [M(N(3)C(5)H(15))(2)](2+) complexes act as countercations and are located between the [{M(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)](4-) anions. Between the anions and cations strong N-H···O hydrogen bonds are observed. In both compounds the clusters are stacked along the b axis in an ABAB fashion with cations and water molecules occupying the space between the clusters. Magnetic characterization demonstrates that the Ni(2+) and Co(2+) cations do not

15 CFR 762.3 - Records exempt from recordkeeping requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

...; (2) Special export file list; (3) Vessel log from freight forwarder; (4) Inspection certificate; (5... form; (12) Financial hold form; (13) Export parts shipping problem form; (14) Draft number log; (15) Expense invoice mailing log; (16) Financial status report; (17) Bank release of guarantees; (18) Cash...

15 CFR 762.3 - Records exempt from recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

...; (2) Special export file list; (3) Vessel log from freight forwarder; (4) Inspection certificate; (5... form; (12) Financial hold form; (13) Export parts shipping problem form; (14) Draft number log; (15) Expense invoice mailing log; (16) Financial status report; (17) Bank release of guarantees; (18) Cash...

The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Facial Acne Vulgaris.

PubMed

Hashim, Peter W; Chen, Tinley; Harper, Julie C; Kircik, Leon H

2018-06-01

Azelaic acid demonstrates anti-inflammatory, anti-oxidative, anti-comedogenic, and anti-microbial effects. Azelaic acid 20% cream is currently approved for the treatment of acne vulgaris, and azelaic acid 15% foam has recently been approved for rosacea. Given the favorable tolerability profile of foam preparations, it is reasonable to assume that azelaic acid 15% foam could serve as a viable treatment option for facial acne. To examine the efficacy and safety of azelaic acid 15% foam in the treatment of moderate-to-severe facial acne Methods: Twenty subjects with moderate-to-severe facial acne vulgaris were enrolled in this two-center, open-label pilot study. All study subjects were treated with azelaic acid 15% foam for 16 weeks. Efficacy analyses were based on the change in facial investigator global assessment (FIGA) and changes in total, inflammatory, non-inflammatory lesion counts between baseline and week 16. There was a significant reduction in FIGA scores from baseline to week 16 (p = .0004), with 84% of subjects experiencing at least a 1 grade improvement, and 63% of subjects achieving a final grade of Clear or Almost Clear. All subjects experienced reductions in inflammatory and total lesion counts by week 16, and 89% of subjects experienced reductions in non-inflammatory lesions. Azelaic acid 15% foam was well tolerated, with almost all instances of erythema, dryness, peeling, oiliness, pruritus, and burning being of mild or trace degree, and most adverse effects resolving by the end of the study. Azelaic acid 15% foam is effective and safe in the treatment of facial acne vulgaris. Given the convenience of foam vehicles, azelaic acid 15% foam should be considered as a viable treatment option for this condition. J Drugs Dermatol. 2018;17(6):641-645.

High resolution measurements supported by electronic structure calculations of two naphthalene derivatives: [1,5]- and [1,6]-naphthyridine--estimation of the zero point inertial defect for planar polycyclic aromatic compounds.

PubMed

Gruet, S; Goubet, M; Pirali, O

2014-06-21

Polycyclic aromatic hydrocarbons (PAHs) molecules are suspected to be present in the interstellar medium and to participate to the broad and unresolved emissions features, the so-called unidentified infrared bands. In the laboratory, very few studies report the rotationally resolved structure of such important class of molecules. In the present work, both experimental and theoretical approaches provide the first accurate determination of the rotational energy levels of two diazanaphthalene: [1,5]- and [1,6]-naphthyridine. [1,6]-naphthyridine has been studied at high resolution, in the microwave (MW) region using a Fourier transform microwave spectrometer and in the far-infrared (FIR) region using synchrotron-based Fourier transform spectroscopy. The very accurate set of ground state (GS) constants deduced from the analysis of the MW spectrum allowed the analysis of the most intense modes in the FIR (ν38-GS centered at about 483 cm(-1) and ν34-GS centered at about 842 cm(-1)). In contrast with [1,6]-naphthyridine, pure rotation spectroscopy of [1,5]-naphthyridine cannot be performed for symmetry reasons so the combined study of the two intense FIR modes (ν22-GS centered at about 166 cm(-1) and ν18-GS centered at about 818 cm(-1)) provided the GS and the excited states constants. Although the analysis of the very dense rotational patterns for such large molecules remains very challenging, relatively accurate anharmonic density functional theory calculations appeared as a highly relevant supporting tool to the analysis for both molecules. In addition, the good agreement between the experimental and calculated infrared spectrum shows that the present theoretical approach should provide useful data for the astrophysical models. Moreover, inertial defects calculated in the GS (ΔGS) of both molecules exhibit slightly negative values as previously observed for planar species of this molecular family. We adjusted the semi-empirical relations to estimate the zero

Dissemination of successful international clone ST15 and clonal complex 17 among Bulgarian CTX-M-15 producing K. pneumoniae isolates.

PubMed

Markovska, Rumyana; Stoeva, Temenuga; Boyanova, Lyudmila; Stankova, Petya; Pencheva, Daniela; Keuleyan, Emma; Murjeva, Marianna; Sredkova, Marya; Ivanova, Dobrinka; Lazarova, Grozdanka; Nedelcheva, Gergana; Kaneva, Radka; Mitov, Ivan

2017-12-01

A total of 82 extended spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae and 4 Klebsiella oxytoca isolates were collected in 2014 from four geographical areas in Bulgaria and their multilocus sequence type (MLST) and transferability of the ESBL encoding genes were investigated. The predominant type was CTX-M-15 (87%), followed by CTX-M-3 (9%), SHV-12 or SHV-2 (2%) and CTX-M-14 (1%). The CTX-M-15 producers belonged to ST15 (34.1%) and to a lesser extent to CC17 (ST16, ST17, ST336). The CTX-M-15 transconjugants showed a presence of R, A/C 2 and F replicons. The CTX-M-3 producers were assigned to ST29, ST70, ST432, ST542 and ST15 types and the transconjugants carried M 2 replicons. To the best of our knowledge, this is the first report that fully describes the MLST types among Bulgarian ESBL producing K. pneumoniae and the first report of the detection of IncR plasmid replicon type in our country. Copyright © 2017 Elsevier Inc. All rights reserved.

Spin reorientation transition and near room-temperature multiferroic properties in a W-type hexaferrite SrZn{sub 1.15}Co{sub 0.85}Fe{sub 16}O{sub 27}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Y. Q.; Fang, Y.; Wang, L. Y.

2014-03-07

In this Letter, we investigate the magnetic and multiferroic properties of a W-type hexaferrite SrZn{sub 1.15}Co{sub 0.85}Fe{sub 16}O{sub 27}. Due to the strong planar contribution to the anisotropy provided by Co{sup 2+} ions, this hexaferrite shows a spin reorientation transition from easy-axis to easy-cone at 302 K, which is different from the onset temperature of ferroelectric polarization, 275 K. By applying magnetic field, a remarkable drop of polarization is observed, suggesting a large magnetoelectric effect in this multiferroics. The difference between spin reorientation and ferroelectric phase transition temperature as well as the origin of magnetoelectric effect are discussed.

Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.

PubMed

Flack, Sheila L; Fent, Kenneth W; Gaines, Linda G T; Thomasen, Jennifer M; Whittaker, Stephen G; Ball, Louise M; Nylander-French, Leena A

2011-05-01

We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N-acetyl-1,6-hexamethylene diamine (monoacetyl-HDA-Hb) by GC-MS. HDA-Hb was detected in the majority of workers (≤1.2-37 ng/g Hb), whereas monoacetyl-HDA-Hb was detected in one worker (0.06 ng/g Hb). The stronger, positive association between HDA-Hb and cumulative HDI exposure (r(2) = 0.3, p < 0.06) than same day exposure (p ≥ 0.13) indicates long-term elimination kinetics for HDA-Hb adducts. This association demonstrates the suitability of HDA-Hb adducts for further validation as a biomarker of HDI exposure.

Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate

PubMed Central