Sample records for hain lifescience gmbh

  1. Haines - Scagway Submarine Cable Intertie Project, Haines to Scagway, Alaska Final Technical and Construction Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    See, Alan; Rinehart, Bennie N; Marin, Glen

    1998-11-01

    The Haines to Skagway submarine cable project is located n Taiya Inlet, at the north end of Lynn Canal, in Southeast Alaska. The cable is approximately 15 miles long, with three landings and splice vaults. The cable is 35 kV, 3-Phase, and armored. The cable interconnects the Goat Lake Hydro Project near Skagway with the community of Haines. Both communities are now on 100% hydroelectric power. The Haines to Skagway submarine cable is the result of AP&T's goal of an alternative, economic, and environmentally friendly energy source for the communities served and to eliminate the use of diesel fuel asmore » the primary source of energy. Diesel units will continue to be used as a backup system.« less

  2. Using a Simple Parcel Model to Investigate the Haines Index

    Treesearch

    Mary Ann Jenkins; Steven K. Krueger; Ruiyu Sun

    2003-01-01

    The Haines Index (Haines 1988) ia fire-weather index based on stability and moisture conditions of the lower atmosphere that rates the potential for large fire growth or extreme fire behavior. The Hained Index is calculated by adding a temperature term a to a moisture term b.

  3. A North American regional reanalysis climatology of the Haines Index

    Treesearch

    Wei Lu; Joseph J. (Jay) Charney; Sharon Zhong; Xindi Bian; Shuhua Liu

    2011-01-01

    A warm-season (May through October) Haines Index climatology is derived using 32-km regional reanalysis temperature and humidity data from 1980 to 2007. We compute lapse rates, dewpoint depressions, Haines Index factors A and B, and values for each of the low-, mid- and high-elevation variants of the Haines Index. Statistical techniques are used to investigate the...

  4. Performance of the Haines Index During August 2000 for Montana

    Treesearch

    Brian E. Potter; Scott Goodrick

    2003-01-01

    The Haines Index, introduced by Haines (1988) as the Lower Atmosphere Severity Index, is designed to gauge how readily the lower mid-troposphere (500 to 4500 m AGL) will spur an otherwise fairly predictable fire to become erratic and unmanageable. Based on stability and moisture, the Haines Index (hereafter, HI) takes on integer values from 2 to 6, with 2 being very...

  5. The Perfect Career: Jennifer Hain-Teper--University of Illinois Library, Urbana-Champaign

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Jennifer Hain-Teper, from the University of Illinois Library. For Jennifer Hain Teper, it all began with a simple question: "If you could do anything at all, regardless of pay, what would it be?" This was posed by a friend when Hain Teper was a volunteer at the wildflower research center in Austin, TX.…

  6. Magnetite deposits near Klukwan and Haines, southeastern Alaska

    USGS Publications Warehouse

    Robertson, Eugene C.

    1956-01-01

    Low-grade iron ore is found in magnetite-bearing pyroxenite bodies near Klukwan and Haines in Southeastern Alaska. An alluvial fan at Haines also contains magnetite-bearing rock of possible economic significance. The Haines-Klukwan area is underlain by rocks of Mesozoic Including epidote diorite, quartz diorite, and alaskite of the Coast Range batholith, metabasalt (recrystallized lava flows and pyroclastic rocks), and, in the southern part, interbedded slate and limestone. Layering and foliation, where perceptible, generally strike northwest and dip steeply northeast. The iron deposits are found at or near the contact between the metabasalt and epidote diorite; they appear to represent highly-altered lava flows that were metamorphosed during the emplacement of the batholith. Several billion tens of rock containing about 13 percent magnetic iron are included in the pyroxenite body at Klukwan. Sampling and dip-needle data suggest the presence there of two or three tabular aches in which the rock has an average magnetic iron content of 20 percent or more. Pyroxenite bodies outcropping in three areas near Haines apparently are lower in grade than the Klukwan deposit; lack of exposures prevented thorough sampling but reconnaissance traverses with a dip needle failed to reveal important zones of high-grade iron ore. An alluvial fan adjoining the pyroxenite body at Klukwan contains several hundred million tons of broken rock having a magneticiron content of about 10 percent.

  7. Climatological and statistical characteristics of the Haines Index for North America

    Treesearch

    Julie A. Winkler; Brian E. Potter; Dwight F. Wilhelm; Ryan P. Shadbolt; Krerk Piromsopa; Xindi Bian

    2007-01-01

    The Haines Index is an operational tool for evaluating the potential contribution of dry, unstable air to the development of large or erratic plume-dominated wildfires. The index has three variants related to surface elevation, and is calculated from temperature and humidity measurements at atmospheric pressure levels. To effectively use the Haines Index, fire...

  8. 33 CFR 165.1712 - Safety Zones; Annual Independence Day Firework Displays, Skagway, Haines, and Wrangell, AK.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Day Firework Displays, Skagway, Haines, and Wrangell, AK. 165.1712 Section 165.1712 Navigation and... Displays, Skagway, Haines, and Wrangell, AK. (a) Regulated areas. The following areas are permanent safety..., Haines, AK within a 300-yard radius around the fireworks launch area, centered at approximate position 59...

  9. 33 CFR 165.1712 - Safety Zones; Annual Independence Day Firework Displays, Skagway, Haines, and Wrangell, AK.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Day Firework Displays, Skagway, Haines, and Wrangell, AK. 165.1712 Section 165.1712 Navigation and... Displays, Skagway, Haines, and Wrangell, AK. (a) Regulated areas. The following areas are permanent safety..., Haines, AK within a 300-yard radius around the fireworks launch area, centered at approximate position 59...

  10. The next phase of life-sciences spaceflight research

    PubMed Central

    Etheridge, Timothy; Nemoto, Kanako; Hashizume, Toko; Mori, Chihiro; Sugimoto, Tomoko; Suzuki, Hiromi; Fukui, Keiji; Yamazaki, Takashi; Higashibata, Akira; Higashitani, Atsushi

    2011-01-01

    Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-tagged proteins to monitor changes in GPF localization during flight. Here we discuss potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research. PMID:22446523

  11. Timber supply and use in the Haines-Skagway area, Alaska.

    Treesearch

    Vernon J. LaBau; O. Keith Hutchison

    1976-01-01

    Discusses the results of a 1965 forest inventory of 449,300 acres in the Haines-Skagway area. Selected references are used to describe the economy of the area historically and currently. Interpretations and assessments of the timber resource in the continuing economy are made.

  12. Comments on the Yule Marble Haines block: potential replacement, Tomb of the Unknown Soldier, Arlington National Cemetery

    USGS Publications Warehouse

    Mossotti, Victor G.

    2014-01-01

    Marble for the Tomb of the Unknown Soldier at Arlington National Cemetery was cut from the Colorado Yule Marble Quarry in 1931. Although anecdotal reports suggest that cracks were noticed in the main section of the monument shortly after its installation at the Arlington National Cemetery in Arlington, Virginia, detailed documentation of the extent of cracking did not appear until 1963. Although debate continues as to whether the main section of the Tomb of the Unknowns monument should be repaired or replaced, Mr. John S. Haines of Glenwood Springs, Colorado, in anticipation of the permanent closing of the Yule Quarry, donated a 58-ton block of Yule Marble, the so-called Haines block, as a potential backup. The brief study reported here was conducted during mid-summer 2009 at the behest of the superintendent of Arlington National Cemetery. The field team entered the subterranean Yule Marble Quarry with the Chief Extraction Engineer in order to contrast the method used for extraction of the Haines block with the method that was probably used to extract the marble block that is now cracked. Based on surficial inspection and shallow coring of the Haines block, and on the nature of crack propagation in Yule Marble as judged by close inspection of a large collection of surrogate Yule Marble blocks, the team found the block to be structurally sound and cosmetically equivalent to the marble used for the current monument. If the Haines block were needed, it would be an appropriate replacement for the existing cracked section of the Tomb of the Unknown Soldier Monument.

  13. 33 CFR 207.170a - Eugene J. Burrell Navigation Lock in Haines Creek near Lisbon, Fla.; use, administration, and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Eugene J. Burrell Navigation Lock in Haines Creek near Lisbon, Fla.; use, administration, and navigation. 207.170a Section 207.170a... REGULATIONS § 207.170a Eugene J. Burrell Navigation Lock in Haines Creek near Lisbon, Fla.; use...

  14. Accuracy of 24- and 48-Hour Forecasts of Haines' Index

    Treesearch

    Brian E. Potter; Jonathan E. Martin

    2001-01-01

    The University of Wisconsin-Madison produces Web-accessible, 24- and 48-hour forecasts of the Haines Index (a tool used to measure the atmospheric potential for large wildfire development) for most of North America using its nonhydrostatic modeling system. The authors examined the accuracy of these forecasts using data from 1999 and 2000. Measures used include root-...

  15. The interannual variability of the Haines Index over North America

    Treesearch

    Lejiang Yu; Shiyuan Zhong; Xindi Bian; Warren E. Heilman; Joseph J. Charney

    2013-01-01

    The Haines index (HI) is a fire-weather index that is widely used as an indicator of the potential for dry, low-static-stability air in the lower atmosphere to contribute to erratic fire behavior or large fire growth. This study examines the interannual variability of HI over North America and its relationship to indicators of large-scale circulation anomalies. The...

  16. Lipidomics informatics for life-science.

    PubMed

    Schwudke, D; Shevchenko, A; Hoffmann, N; Ahrends, R

    2017-11-10

    Lipidomics encompasses analytical approaches that aim to identify and quantify the complete set of lipids, defined as lipidome in a given cell, tissue or organism as well as their interactions with other molecules. The majority of lipidomics workflows is based on mass spectrometry and has been proven as a powerful tool in system biology in concert with other Omics disciplines. Unfortunately, bioinformatics infrastructures for this relatively young discipline are limited only to some specialists. Search engines, quantification algorithms, visualization tools and databases developed by the 'Lipidomics Informatics for Life-Science' (LIFS) partners will be restructured and standardized to provide broad access to these specialized bioinformatics pipelines. There are many medical challenges related to lipid metabolic alterations that will be fostered by capacity building suggested by LIFS. LIFS as member of the 'German Network for Bioinformatics' (de.NBI) node for 'Bioinformatics for Proteomics' (BioInfra.Prot) and will provide access to the described software as well as to tutorials and consulting services via a unified web-portal. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Life-science research within US academic medical centers.

    PubMed

    Zinner, Darren E; Campbell, Eric G

    2009-09-02

    Besides the generic "basic" vs "applied" labels, little information is known about the types of life-science research conducted within academic medical centers (AMCs). To determine the relative proportion, characteristics, funding, and productivity of AMC faculty by the type of research they conduct. Mailed survey conducted in 2007 of 3080 life-science faculty at the 50 universities with medical schools that received the most funding from the National Institutes of Health in 2004. Response rate was 74%. Research faculty affiliated with a medical school or teaching hospital, representing 77% of respondents (n = 1663). Type of research (basic, translational, clinical trials, health services research/clinical epidemiology, multimode, other), total funding, industry funding, publications, professional activities, patenting behavior, and industry relationships. Among AMC research faculty, 33.6% exclusively conducted basic science research as principal investigators compared with translational researchers (9.1%), clinical trial investigators (7.1%), and health services researchers/clinical epidemiologists (9.0%). While principal investigators garnered a mean of $410,755 in total annual research funding, 22.1% of all AMC research faculty were unsponsored, a proportion that ranged from 11.5% for basic science researchers to 46.8% for health services researchers (P < .001). The average AMC faculty member received $33,417 in industry-sponsored funding, with most of this money concentrated among clinical trial ($110,869) and multimode ($59,916) principal investigators. Translational (61.3%), clinical trial (67.3%), and multimode (70.9%) researchers were significantly more likely than basic science researchers (41.9%) to report a relationship with industry and that these relationships contributed to their most important scientific work (P < .05 for all comparisons). The research function of AMCs is active and diverse, incorporating a substantial proportion of faculty who are

  18. Akuginow and Haines-Stiles Receive 2013 Robert C. Cowen Journalism Award: Citation

    NASA Astrophysics Data System (ADS)

    Alley, Richard

    2014-01-01

    From Cosmos to Mars and Pluto and back home, Geoffrey Haines-Stiles and Erna Akuginow have invested their careers reporting the best modern science in novel, compelling, and accessible ways through documentaries, live events, print, and new media. They are outstanding recipients of the AGU Robert C. Cowen Award for Sustained Achievement in Science Journalism.

  19. An examination of the sensitivity of numerically simulated wildfires to low-level atmospheric stability and moisture, and the consequences for the Haines Index

    Treesearch

    Mary Ann Jenkins

    2002-01-01

    The Haines Index, an operational fire-weather index introduced in 1988 and based on the observed stability and moisture content of the near-surface atmosphere, has been a useful indicator of the potential for high-risk fires in low wind conditions and flat terrain. The Haines Index is of limited use, however, as a predictor of actual fire behavior. To develop a fire-...

  20. Reconnaissance engineering geology of the Haines area, Alaska, with emphasis on evaluation of earthquake and other geologic hazards

    USGS Publications Warehouse

    Lemke, Richard Walter; Yehle, Lynn A.

    1972-01-01

    The Alaska earthquake of March 27, 1964, brought into sharp focus the need for engineering geologic studies in urban areas. Study of the Haines area constitutes an integral part of an overall program to evaluate earthquake and other geologic hazards in most of the larger Alaska coastal communities. The evaluations of geologic hazards that follow, although based only upon reconnaissance studies and, therefore, subject to revision, will provide broad guidelines useful in city and land-use planning. It is hoped that the knowledge gained will result in new facilities being built in the best possible geologic environments and being designed so as to minimize future loss of life and property damage. Haines, which is in the northern part of southeastern Alaska approximately 75 miles northwest of Juneau, had a population, of about 700 people in 1970. It is built at the northern end of the Chilkat Peninsula and lies within the Coast Mountains of the Pacific Mountain system. The climate is predominantly marine and is characterized by mild winters and cool summers. The mapped area described in this report comprises about 17 square miles of land; deep fiords constitute most of the remaining mapped area that is evaluated in this study. The Haines area was covered by glacier ice at least once and probably several times during the Pleistocene Epoch. The presence of emergent marine deposits, several hundred feet above sea level, demonstrates that the land has been uplifted relative to sea level since the last major deglaciation of the region about 10,000 years ago. The rate of relative uplift of the land at Haines during the past 39 years is 2.26 cm per year. Most or all of this uplift appears to be due to rebound as a result of deglaciation. Both bedrock and surficial deposits are present in the area. Metamorphic and igneous rocks constitute the exposed bedrock. The metamorphic rocks consist of metabasalt of Mesozoic age and pyroxenite of probable early middle Cretaceous age. The

  1. Microfluidic-Based Platform for Universal Sample Preparation and Biological Assays Automation for Life-Sciences Research and Remote Medical Applications

    NASA Astrophysics Data System (ADS)

    Brassard, D.; Clime, L.; Daoud, J.; Geissler, M.; Malic, L.; Charlebois, D.; Buckley, N.; Veres, T.

    2018-02-01

    An innovative centrifugal microfluidic universal platform for remote bio-analytical assays automation required in life-sciences research and medical applications, including purification and analysis from body fluids of cellular and circulating markers.

  2. The Acquisition of Selected Life-Science Concepts by Beginning Kindergarten Children From Three Different Community Settings.

    ERIC Educational Resources Information Center

    Riechard, Donald Edward

    Physical, mental, and socio-cultural variables were associated with performance on the Life-Science Concept Acquisition Test (L-SCAT), developed by the investigator. The usefulness of the variables as predictors of performance on L-SCAT was also investigated. The L-SCAT was administered as a picture-stimulus structured interview to each of 51…

  3. Application of the Haines Index in the fire warning system

    NASA Astrophysics Data System (ADS)

    Kalin, Lovro; Marija, Mokoric; Tomislav, Kozaric

    2016-04-01

    Croatia, as all Mediterranean countries, is strongly affected by large wildfires, particularly in the coastal region. In the last two decades the number and intensity of fires has been significantly increased, which is unanimously associated with climate change, e.g. global warming. More extreme fires are observed, and the fire-fighting season has been expanded to June and September. The meteorological support for fire protection and planning is therefore even more important. At the Meteorological and Hydrological Service of Croatia a comprehensive monitoring and warning system has been established. It includes standard components, such as short term forecast of Fire Weather Index (FWI), but long range forecast as well. However, due to more frequent hot and dry seasons, FWI index often does not provide additional information of extremely high fire danger, since it regularly takes the highest values for long periods. Therefore the additional tools have been investigated. One of widely used meteorological products is the Haines index (HI). It provides information of potential fire growth, taking into account only the vertical instability of the atmosphere, and not the state of the fuel. Several analyses and studies carried out at the Service confirmed the correlation of high HI values with large and extreme fires. The Haines index forecast has been used at the Service for several years, employing European Centre for Medium Range Weather Forecast (ECMWF) global prediction model, as well as the limited-area Aladin model. The verification results show that these forecast are reliable, when compared to radiosonde measurements. All these results provided the introduction of the additional fire warnings, that are issued by the Service's Forecast Department.

  4. Preliminary research findings from a study of the sociocultural effects of tourism in Haines, Alaska.

    Treesearch

    Lee K. Cerveny

    2004-01-01

    This report examines the growth and development of the tourism industry in Haines, Alaska, and its effects on community life and land use. It also describes the development of cruise-based tourism and its relation to shifts in local social and economic structures and patterns of land use, especially local recreation use trends. A multisited ethnographic approach was...

  5. Climatic variability of a fire-weather index based on turbulent kinetic energy and the Haines Index

    Treesearch

    Warren E. Heilman; Xindi Bian

    2010-01-01

    Combining the Haines Index (HI) with near-surface turbulent kinetic energy (TKEs) through a product of the two values (HITKEs) has shown promise as an indicator of the atmospheric potential for extreme and erratic fire behavior in the U.S. Numerical simulations of fire-weather evolution during past wildland fire episodes in...

  6. [Heavy metal pollution characteristics and ecological risk analysis for soil around Haining electroplating industrial park].

    PubMed

    Li, Jiong-Hui; Weng, Shan; Fang, Jing; Huang, Jia-Lei; Lu, Fang-Hua; Lu, Yu-Hao; Zhang, Hong-Ming

    2014-04-01

    The pollution status and potential ecological risks of heavy metal in soils around Haining electroplating industrial park were studied. Hakanson index approach was used to assess the ecological hazards of heavy metals in soils. Results showed that average concentrations of six heavy metals (Cu, Ni, Pb, Zn, Cd and Cr) in the soils were lower than the secondary criteria of environmental quality standard for soils, indicating limited harmful effects on the plants and the environment in general. Though the average soil concentrations were low, heavy metal concentrations in six sampling points located at the side of road still exceeded the criteria, with excessive rate of 13%. Statistic analysis showed that concentrations of Cu and Cd in roadside soils were significantly higher than those in non-roadside soils, indicating that the excessive heavy metal accumulations in the soil closely related with traffic transport. The average potential ecological hazard index of soils around Haining electroplating industrial park was 46.6, suggesting a slightly ecological harm. However, the potential ecological hazard index of soils with excessive heavy metals was 220-278, suggesting the medium ecological hazards. Cd was the most seriously ecological hazard factor.

  7. Effects of Node-Link Mapping on Non-Science Majors' Meaningful Learning and Conceptual Change in a Life-Science Survey Lecture Course

    ERIC Educational Resources Information Center

    Park-Martinez, Jayne Irene

    2011-01-01

    The purpose of this study was to assess the effects of node-link mapping on students' meaningful learning and conceptual change in a 1-semester introductory life-science course. This study used node-link mapping to integrate and apply the National Research Council's (NRC, 2005) three principles of human learning: engaging students' prior…

  8. PCR identification of bacteria in blood culture does not fit the daily workflow of a routine microbiology laboratory.

    PubMed

    Karumaa, Santra; Kärpänoja, Pauliina; Sarkkinen, Hannu

    2012-03-01

    We have evaluated the GenoType blood culture assay (Hain Lifescience, Nehren, Germany) for the identification of bacteria in 233 positive blood cultures and assessed its suitability in the workflow of a routine microbiology laboratory. In 68/233 (29.2%) samples, the culture result could not be confirmed by the GenoType assay due to a lack of primers in the test, multiple organisms in the sample, or inconsistency with respect to the identification by culture. Although the GenoType blood culture assay gives satisfactory results for bacteria for which primers are available, there are difficulties in applying the test in the routine microbiology laboratory.

  9. The Accuracy of Temperature Measurements Provided by the Edwards Lifesciences Pulmonary Artery Catheter.

    PubMed

    Launey, Yoann; Larmet, Raphaëlle; Nesseler, Nicolas; Malledant, Yannick; Palpacuer, Clément; Seguin, Philippe

    2016-05-01

    Pulmonary artery catheters (PACs) are frequently used for monitoring patient temperatures in the intensive care unit. Nevertheless, data regarding the accuracy of these measurements are lacking, and few data testify to the accuracy of temperatures recorded after the PAC has been in place for several days. The absolute values of such measurements are relevant for critical care because patient temperatures are often used as diagnostic criteria for sepsis and antibiotic therapy. We thus hypothesized that the Edwards Lifesciences PAC would accurately measure blood temperature. To test our hypothesis, we compared temperature measurements obtained from PACs inserted in patients for different lengths of time with measurements of a reference platinum resistance thermometer (PRT). PACs were removed and analyzed in 39 patients in whom PACs were inserted for 0 to 5 days. The PACs were placed in calibration baths, and 10 consecutive measurements at each of 7 different temperatures were obtained (36°C, 36.5°C, 37°C, 38°C, 38.3°C, 39°C, and 40°C). The temperature measurements obtained using PACs were compared with measurements obtained using a PRT. Bland-Altman statistical analyses were performed. Outliers, defined as PAC temperature measurements that varied more than ±0.3°C from PRT measurements, were identified. We considered a catheter unfit for clinical diagnostic or therapeutic use if ≥15% of data pairs were outliers. A total of 2730 data pairs were analyzed. Overall, the bias was -0.15°C; the precision was +0.13°C; and the limits of agreement were -0.45°C to +0.13°C. The bias and limits of agreement did not differ according to the age of the catheter or the temperature tested. One hundred fourteen data pairs (4.2% [95% confidence interval, 2.0%-6.4%]), involving 13 PACs and mostly from 4 PACs, were outliers. We conclude that temperature measurements obtained using the Edwards Lifesciences PACs are thus sufficiently accurate to be used for clinical

  10. Project management of life-science research projects: project characteristics, challenges and training needs.

    PubMed

    Beukers, Margot W

    2011-02-01

    Thirty-four project managers of life-science research projects were interviewed to investigate the characteristics of their projects, the challenges they faced and their training requirements. A set of ten discriminating parameters were identified based on four project categories: contract research, development, discovery and call-based projects--projects set up to address research questions defined in a call for proposals. The major challenges these project managers are faced with relate to project members, leadership without authority and a lack of commitment from the respective organization. Two-thirds of the project managers indicated that they would be interested in receiving additional training, mostly on people-oriented, soft skills. The training programs that are currently on offer, however, do not meet their needs. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. Detection of KatG/inhA Mutation to Guide Isoniazid and Ethionamide Use for Drug-resistant Tuberculosis

    PubMed Central

    Namburete, Evangelina

    2017-01-01

    Abstract Background Both Mozambique and Brazil are countries with a high burden of tuberculosis. Isoniazid (INH) is one of the cornerstones of tuberculosis treatment and, depending on the mutated gene (katG or inhA), the organism may be susceptible to high doses of INH (inhA mutation) or to ethionamide (-Eth-KatG mutation). Methods To analyze isoniazid genotypic resistance profile in Mycobacterium tuberculosis to guide decision making about management of resistant tuberculosis. Descriptive study of 311 M. tuberculosis isolated from Ribeirão Preto, Brazil (2011–2014) and 155 isolates from Beira, Mozambique (2014–2015). Drug resistance patterns and the specific genes mutations were determined using Genotype MTBDRplus (Hain Lifescience GmbH, Germany). Results Mutations in katG gene were detected in 13/22 (59%) of Brazilian and in 32/38 (84.2%) of Mozambican isolates. Unique inhA mutations were observed in 8/22 (36%) isolates in Brazil and 4/38 (10.5%) in Mozambique. Both katG and inhA mutations where detected in 1/22 (5%) and 2/38(5.2%), respectively. katG mutations were more frequent among INH previously treated patients. Conclusion There is a geographical variation of INH mutations and the new molecular tests can be used to guide and accelerate decision making towards the use of ETH or high doses of INH based on detected mutations. Disclosures All authors: No reported disclosures.

  12. 77 FR 20526 - Airworthiness Directives; 328 Support Services GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... directive (AD) for all 328 Support Services GmbH (Type Certificate previously held by AvCraft Aerospace GmbH... GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier... applies to 328 Support Services GmbH (Type Certificate previously held by AvCraft Aerospace GmbH...

  13. Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

    NASA Astrophysics Data System (ADS)

    Kitagawa, A.; Drentje, A. G.; Fujita, T.; Muramatsu, M.; Fukushima, K.; Shiraishi, N.; Suzuki, T.; Takahashi, K.; Takasugi, W.; Biri, S.; Rácz, R.; Kato, Y.; Uchida, T.; Yoshida, Y.

    2016-02-01

    With about 1000-h of relativistic high-energy ion beams provided by Heavy Ion Medical Accelerator in Chiba, about 70 users are performing various biology experiments every year. A rich variety of ion species from hydrogen to xenon ions with a dose rate of several Gy/min is available. Carbon, iron, silicon, helium, neon, argon, hydrogen, and oxygen ions were utilized between 2012 and 2014. Presently, three electron cyclotron resonance ion sources (ECRISs) and one Penning ion source are available. Especially, the two frequency heating techniques have improved the performance of an 18 GHz ECRIS. The results have satisfied most requirements for life-science studies. In addition, this improved performance has realized a feasible solution for similar biology experiments with a hospital-specified accelerator complex.

  14. 76 FR 77159 - Airworthiness Directives; 328 Support Services GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... Services GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Services GmbH (Type Certificate previously held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 and -300 airplanes that would supersede an existing AD. This proposed AD...

  15. 77 FR 3583 - Airworthiness Directives; 328 Support Services GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Airworthiness Directives; 328 Support Services GmbH Airplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for all 328 Support Services GmbH (Type Certificate previously held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 and 328-300 airplanes. This AD was prompted by...

  16. Modifying ``Six Ideas that Shaped Physics'' for a Life-Science major audience at Hope College

    NASA Astrophysics Data System (ADS)

    Mader, Catherine

    2005-04-01

    The ``Six Ideas That Shaped Physics'' textbook has been adapted and used for use in the algebra-based introductory physics course for non-physics science majors at Hope College. The results of the first use will be presented. Comparison of FCI for pre and post test scores will be compared with results from 8 years of results from both the algebra-based course and the calculus-based course (when we first adopted ``Six Ideas that Shaped Physcs" for the Calculus-based course). In addition, comparison on quantitative tests and homework problems with prior student groups will also be made. Because a large fraction of the audience in the algebra-based course is life-science majors, a goal of this project is to make the material relevant for these students. Supplemental materials that emphasize the connection between the life sciences and the fundamental physics concepts are being be developed to accompany the new textbook. Samples of these materials and how they were used (and received) during class testing will be presented.

  17. Detection of periodontopathogenic bacteria in pregnant women by traditional anaerobic culture method and by a commercial molecular genetic method.

    PubMed

    Urbán, Edit; Terhes, Gabriella; Radnai, Márta; Gorzó, István; Nagy, Elisabeth

    2010-06-01

    To culture facultative and strict anaerobic bacteria is a well-established method for analyzing subgingival plaque samples. Micro-IDent and micro-IDent Plus (HAIN Lifescience GmbH, Nehren, Germany) tests are two commercially available rapid PCR-based methods for the identification and quantification of putative periodontopathogen bacteria. In this study, we compared these commercial PCR-based hybridization methods with conventional anaerobic culture technique. A total of 36 subgingival plaque samples were collected from periodontal pockets of pregnant women with chronic localized periodontitis. Aliquots of these samples were evaluated with species-specific probes provided by micro-IDent and micro-IDent Plus tests simultaneously, and from the same samples anaerobic and capnophylic bacteria were cultured on selective media. The overall agreement between both methods was excellent for Eubacterium nodatum, Tannerella forsythia and Porphyromonas gingivalis (97-92%), fair for Capnocytophaga sp, Eikenella corrodens, Actinobacillus actinomycetemcomitans, and Prevotella intermedia (91-89%) and poor for Fusobacterium nucleatum, Parvimonas micra (Micromonas micros), and Campylobacter rectus (86-78%). Discrepancies in the results may be explained by inability of culture method to distinguish between closely related taxa (e.i P. intermedia/Prevotella. nigrescens), and problems of keeping periodontopathogen bacteria viable, which is required for successful detection by standard culture method. Nucleic acid-based methods may replace cultivation method as frequently used methods in microbiological diagnosis of progressive periodontitis, thus micro-IDent and micro-IDent Plus tests can be recommended where culture of periodontopathogenic bacteria is not performed in routine microbiology laboratories to analyze subgingival plaque samples. 2010 Elsevier Ltd. All rights reserved.

  18. 78 FR 44039 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters with a jettisonable sliding door (door) installed... airworthiness directive (AD): Eurocopter Deutschland GmbH Helicopters (Eurocopter): Docket No. FAA-2013-0642...

  19. 77 FR 75073 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Supplemental notice... proposed airworthiness directive (AD) for Eurocopter Deutschland GmbH (Eurocopter) Model BO-105A, BO- 105C... airworthiness directive (AD): Eurocopter Deutschland GmbH: Docket No. FAA-2011-1285; Directorate Identifier 2010...

  20. 78 FR 42409 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA...) for Eurocopter Deutschland GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters. This AD requires... directive (AD): 2013-12-05 Eurocopter Deutschland GmbH Helicopters: Amendment 39- 17483; Docket No. FAA-2013...

  1. 78 FR 7312 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration, DOT. ACTION: Notice of proposed... Deutschland GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters. This proposed AD would require changing the... new Airworthiness Directive (AD): Eurocopter Deutschland GmbH: Docket No. FAA-2013-0021; Directorate...

  2. 77 FR 37790 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Eurocopter Deutschland GmbH (ECD) Model EC135 helicopters. The existing EAD, which was previously sent to all... new airworthiness directive (AD): 2012-11-02 Eurocopter Deutschland GmbH: Amendment 39-17065; Docket...

  3. 77 FR 42958 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... airworthiness directive (AD) for Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 (all versions) and BO-105LS... Eurocopter Deutschland GmbH Helicopters: Amendment 39- 17113; Docket No. FAA-2012-0704; Directorate...

  4. 78 FR 77380 - Airworthiness Directives; Dornier Luftfahrt GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... (AD) for Dornier Luftfahrt GmbH Models Dornier 228-100, 228-101, 228-200, 228- 201, 228-202, and 228... holidays. For service information identified in this proposed AD, contact RUAG Aerospace Services GmbH...

  5. 78 FR 31394 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... airworthiness directive (AD) for Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 C-2 helicopters. This AD... directive (AD): 2013-10-05 Eurocopter Deutschland GmbH Helicopters: Amendment 39- 17458; Docket No. FAA-2013...

  6. 78 FR 25361 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT... Deutschland GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters. This AD requires inspecting the long tail... directive (AD): 2013-03-18 Eurocopter Deutschland GmbH (Eurocopter): Amendment 39- 17352; Docket No. FAA...

  7. 78 FR 69320 - Airworthiness Directives; DORNIER LUFTFAHRT GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... (AD) for all DORNIER LUFTFAHRT GmbH Model 228-212 airplanes. This proposed AD results from mandatory... proposed AD, contact RUAG Aerospace Services GmbH, Dornier 228 Customer Support, P.O. Box 1253, 82231...

  8. 77 FR 2234 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for DG Flugzeugbau GmbH Models DG-500 Elan Orion, DG-500 Elan Trainer... DG- Flugzeugbau GmbH, Otto-Lilienthal-Weg 2, 76646 Bruchsal, Federal Republic of Germany; telephone...

  9. 77 FR 21400 - Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for DG Flugzeugbau GmbH Models DG-500 Elan Orion, DG-500 Elan Trainer, DG-500/ 20 Elan, and...., Washington, DC 20590. For service information identified in this AD, contact DG Flugzeugbau GmbH, Otto...

  10. 78 FR 67013 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... Flugzeugbau GmbH Models DG-800A, DG-800B, DG-500MB gliders. This AD results from mandatory continuing... holidays. For service information identified in this AD, contact DG- Flugzeugbau GmbH, 76646 Bruchsal...

  11. 78 FR 4090 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters. This proposed AD would require determining if a... amends Sec. 39.13 by adding the following new airworthiness directive (AD): Eurocopter Deutschland GmbH...

  12. 78 FR 9792 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), Department... (AD) for DG Flugzeugbau GmbH Model DG-1000T gliders equipped with Solo Kleinmotoren Model 2350 C..., contact Solo Kleinmotoren GmbH, Postfach 60 01 52, D 71050 Sindelfingen, Germany; telephone: +49 07031-301...

  13. 78 FR 44050 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Deutschland GmbH (Eurocopter) Model EC135P2+ and EC135T2+ helicopters. This proposed AD would require... adding the following new airworthiness directive (AD): Eurocopter Deutschland GmbH Helicopters: Docket No...

  14. 78 FR 65869 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... Flugzeugbau GmbH Model DG-1000T glider equipped with a Solo Kleinmotoren Model 2350 C engine. This AD results... in this AD, contact Solo Kleinmotoren GmbH, Postfach 60 01 52, D 71050 Sindelfingen, Germany...

  15. 77 FR 43736 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration, DOT. ACTION: Notice of proposed... Deutschland GmbH (Eurocopter) Model MBB-BK 117 C-2 helicopters. This proposed AD is prompted by the discovery... Deutschland GmbH: Docket No. FAA-2012-0773; Directorate Identifier 2009-SW-71-AD. (a) Applicability This AD...

  16. 78 FR 40047 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH (ECD) Model EC135 and MBB-BK 117 C-2 helicopters. This proposed AD is prompted by the discovery... amends Sec. 39.13 by adding the following new airworthiness directive (AD): Eurocopter Deutschland GmbH...

  17. 78 FR 18920 - Airworthiness Directives; Austro Engine GmbH Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ...-0164; Directorate Identifier 2013-NE-10-AD] RIN 2120-AA64 Airworthiness Directives; Austro Engine GmbH...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all Austro Engine GmbH model E4.... Fax: 202-493-2251. For service information identified in this proposed AD, contact Austro Engine GmbH...

  18. 77 FR 19063 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), Department... (AD) for DG Flugzeugbau GmbH Models DG-500 Elan Orion, DG-500 Elan Trainer, DG-500/ 20 Elan, DG-500/22... identified in this AD, contact DG- Flugzeugbau GmbH, Otto-Lilienthal-Weg 2, 76646 Bruchsal, Federal Republic...

  19. 78 FR 65169 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Deutschland GmbH (Eurocopter) Model EC135 P1, P2, P2+, T1, T2, and T2+ helicopters. This AD requires... GmbH: Amendment 39-17629; Docket No. FAA-2013-0446; Directorate Identifier 2010-SW-007-AD. (a...

  20. 77 FR 72913 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Eurocopter Deutschland GmbH (ECD) Model EC135 helicopters, except the EC 135 P2+ and T2+. This AD requires... apply to all Eurocopter Deutschland GmbH (ECD) model EC135 helicopters, except the EC 135 P2+ and T2...

  1. 77 FR 44116 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Eurocopter Deutschland GmbH (ECD) MBB-BK 117 A-3, MBB-BK 117 A-4, MBB- BK B-1, MBB-BK 117 B-2, and MBB-BK C-1... directive (AD): 2012-14-14 Eurocopter Deutschland GmbH Helicopters: Amendment 39- 17128; Docket No. FAA-2012...

  2. 77 FR 27661 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Deutschland GmbH (ECD) model EC135 helicopters, except the EC 135 P2+ and T2+. This proposed AD was prompted...) Applicability This AD applies to all Eurocopter Deutschland GmbH (ECD) Model EC135 helicopters, except EC 135 P2...

  3. 78 FR 2223 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH (Eurocopter) Model BO-105A, BO-105C, BO- 105S, BO-105LS A-1, BO-105LS A-3, EC135 P1, EC135 P2... new airworthiness directive (AD): Eurocopter Deutschland GmbH: Docket No. FAA-2012-1305; Directorate...

  4. 76 FR 76068 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH Model BO-105A, BO-105C, BO-105LS A-1, BO- 105LS A-3, and BO-105S helicopters. This proposed AD... airworthy main rotor blade. Note 1: Eurocopter Deutschland GmbH Emergency Alert Service Bulletin No. BO105...

  5. 78 FR 37446 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Deutschland GmbH (Eurocopter) Model BO-105A, BO-105C, BO- 105S, BO-105LS A-1, BO-105LS A-3, EC135 P1, EC135 P2... new airworthiness directive (AD): 2013-11-15 Eurocopter Deutschland GmbH: Amendment 39-17475; Docket...

  6. 78 FR 56597 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Deutschland GmbH (ECD) Model EC135P1, EC135P2, EC135P2+, EC135T1, EC135T2, and EC135T2+ helicopters with... directive (AD): 2013-18-05 Eurocopter Deutschland GmbH: Amendment 39-17578; Docket No. FAA-2013-0398...

  7. 78 FR 26715 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... GmbH (ECD) Model EC135P1, EC135P2, EC135P2+, EC135T1, EC135T2, and EC135T2+ helicopters with certain... airworthiness directive (AD): Eurocopter Deutschland GmbH: Docket No. FAA-2013-0398; Directorate Identifier 2011...

  8. 78 FR 52410 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Deutschland GmbH (ECD) Model BO-105A, BO-105C, BO-105S, BO- 105LS A-1, BO-105LS A-3, MBB-BK 117 A-1, MBB-BK... directive (AD): 2013-16-13 Eurocopter Deutschland GmbH (ECD): Amendment 39-17551; Docket No. FAA-2012-0887...

  9. 77 FR 20321 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Deutschland GmbH (ECD) MBB-BK 117 A-3, MBB-BK 117 A-4, MBB- BK B-1, MBB-BK 117 B-2, and MBB-BK C-1 helicopters... Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 A-4 model. The EASA AD makes no mention of this model. The...

  10. 78 FR 49115 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA...) that was published in the Federal Register. The AD applies to certain Eurocopter Deutschland GmbH...

  11. 78 FR 72568 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes AGENCY: Federal Aviation Administration... airworthiness directive (AD) for Diamond Aircraft Industries GmbH Models DA40 and DA40F airplanes. This AD..., contact Diamond Aircraft Industries GmbH, N.A. Otto-Str.5, A-2700 Wiener Neustadt, Austria; telephone: +43...

  12. 78 FR 40642 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... Industries GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... (AD) for Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG airplanes. This... Diamond Aircraft Industries GmbH, N.A. Otto-Str.5, A-2700 Wiener Neustadt, Austria; telephone: +43 2622...

  13. 78 FR 59223 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes AGENCY: Federal Aviation Administration... airworthiness directive (AD) for Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG... information identified in this AD, contact Diamond Aircraft Industries GmbH, N.A. Otto-Str.5, A-2700 Wiener...

  14. 77 FR 65503 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... Industries GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... (AD) for Diamond Aircraft Industries GmbH Models DA 42, DA 42 M-NG, and DA 42 NG airplanes. This... Diamond Aircraft Industries GmbH, N.A. Otto-Stra[szlig]e 5, A-2700 Wiener Neustadt, Austria, telephone...

  15. 77 FR 35890 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... Industries GmbH Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... (AD) for certain Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG airplanes... information identified in this proposed AD, contact Diamond Aircraft Industries GmbH, N.A. Otto-Stra[szlig]e 5...

  16. 77 FR 49705 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... Deutschland GmbH Model MBB-BK 117 C-2 helicopters. A page reference of the rotorcraft flight manual in the...

  17. 78 FR 30793 - Airworthiness Directives; Eurocopter Deutschland GmbH Model Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Deutschland GmbH Model Helicopters AGENCY: Federal Aviation Administration (FAA) DOT. ACTION: Notice of... Deutschland GmbH (Eurocopter) Model EC135 P1, P2, P2+, T1, T2, and T2+ helicopters to require inspecting each...): Eurocopter Deutschland GmbH: Docket No. FAA-2013-0446; Directorate Identifier 2010-SW-007-AD. (a...

  18. 77 FR 27659 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Deutschland GmbH (ECD) Model BO-105A, BO-105C, and BO-105S helicopters. This proposed AD is prompted by...

  19. 78 FR 30791 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Schleicher GmbH & Co. Segelflugzeugbau Sailplanes AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for all Alexander Schleicher GmbH & Co. Segelflugzeugbau Models AS... proposed AD, contact Alexander Schleicher GmbH & Co Segelflugzeugbau, Stra[szlig]e 1 D-- 36163 Poppenhausen...

  20. 78 FR 70216 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines AGENCY: Federal Aviation... all Thielert Aircraft Engines GmbH TAE 125-01 reciprocating engines. This AD requires applying sealant... directive (AD): 2013-24-06 Thielert Aircraft Engines GmbH: Amendment 39-17680; Docket No. FAA-2013-0561...

  1. 77 FR 71359 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ...H Gliders AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION... DG Flugzeugbau GmbH Model DG-1000T gliders equipped with Solo Kleinmotoren Model 2350 C engines. This... proposed AD, contact Solo Kleinmotoren GmbH, Postfach 60 01 52, D 71050 Sindelfingen, Germany; telephone...

  2. 77 FR 2236 - Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ...H Sailplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... are revising an earlier NPRM for DG Flugzeugbau GmbH DG-500 Elan series sailplanes and Models DG-500M... information identified in this proposed AD, DG Flugzeugbau GmbH, Otto-Lilienthal-Weg 2, 76646 Bruchsal...

  3. 77 FR 37777 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... directive (AD) for all Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 C-2 helicopters. That AD currently... Safety Agency AD No. 2011-0162, dated August 30, 2011. (h) Subject Joint Aircraft Service Component (JASC...

  4. 77 FR 55105 - Airbus Operations GmbH Grant of Exemption No. 10611

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ...] Airbus Operations GmbH Grant of Exemption No. 10611 AGENCY: Federal Aviation Administration (FAA), DOT... Exemption Docket No.: FAA-2012-0429. Petitioner: Airbus Operations GmbH. Sections of 14 CFR Affected: Part... Operations GmbH. The exemption from 14 CFR 121.344(f) and Appendix M is granted to the extent necessary to...

  5. 77 FR 71487 - Airworthiness Directives; Stemme GmbH & Co. KG Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... Airworthiness Directives; Stemme GmbH & Co. KG Powered Sailplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for all Stemme GmbH & Co. KG Models S10, S10-V, and S10-VT powered sailplanes. This AD... damage to the sailplane and/or injury of occupants. Prompted by these findings, Stemme GmbH developed a...

  6. 77 FR 69558 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA... airworthiness directive (AD) for Eurocopter Deutschland GmbH (ECD) Model EC135 P1, EC135 P2, EC135 P2+, EC135 T1... with this AD through an AMOC. (h) Additional Information (1) Eurocopter Emergency Alert Service...

  7. 77 FR 57531 - Airworthiness Directives; Stemme GmbH & Co. KG Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ...-0982; Directorate Identifier 2012-CE-035-AD] RIN 2120-AA64 Airworthiness Directives; Stemme GmbH & Co... directive (AD) for all Stemme GmbH & Co. KG Models S10, S10-V, and S10-VT powered sailplanes. This proposed... injury of occupants. Prompted by these findings, Stemme GmbH developed a procedure for identification of...

  8. GENOSENSE Diagnostics GmbH.

    PubMed

    Schneeberger, Christian

    2004-07-01

    GENOSENSE Diagnostics GmbH, a company specialized in preventive genetic diagnostics, has committed itself to applying molecular medical knowledge to realizing the vision of individual, preventive and patient-tailored medicine. GENOSENSE offers a unique line of preventive genomic diagnostic profiles. Each profile focuses on a carefully selected set of polymorphisms associated with particular diseases or physiologic imbalances. GENOSENSE does not only provide the genetic test results, but highly capable medical experts 'translate' the results into a clinical language and assist the customer with established support regarding their medical interpretation. In addition, the company provides academic institutions and pharmaceutical companies with turnkey solutions for research-based projects.

  9. 75 FR 7936 - Airworthiness Directives; SCHEIBE-Flugzeugbau GmbH Model SF 25C Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Airworthiness Directives; SCHEIBE-Flugzeugbau GmbH Model SF 25C Gliders AGENCY: Federal Aviation Administration.... Relevant Service Information SCHEIBE-Flugzeugbau GmbH has issued SCHEIBE AIRCRAFT GMBH Service Bulletin 653... SCHEIBE-Flugzeugbau GmbH: Amendment 39-16208; Docket No. FAA-2010-0125; Directorate Identifier 2010-CE-005...

  10. 77 FR 13488 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Reciprocating Engines AGENCY: Federal Aviation... this AD, contact Thielert Aircraft Engines GmbH, Platanenstrasse 14 D-09350, Lichtenstein, Germany... following new AD: 2010-11-09R1 Thielert Aircraft Engines GmbH: Amendment 39-16972; Docket No. FAA-2009-0201...

  11. 78 FR 52412 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters AGENCY: Federal Aviation Administration... new airworthiness directive (AD): 2013-16-20 Eurocopter Deutschland GmbH (ECD): Amendment 39-17558... the EASA AD at http://www.regulations.gov in Docket No. FAA-2013-0020. (h) Subject Joint Aircraft...

  12. 78 FR 67020 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters AGENCY: Federal Aviation Administration... the AD Docket at http://www.regulations.gov . (h) Subject Joint Aircraft Service Component (JASC) Code..., of Eurocopter Deutschland GmbH Flight Manual BO 105 C/CS, Revision 5, dated March 12, 2010. (ii...

  13. Using Haines Index coupled with fire weather model predicted from high resolution LAM forecasts to asses wildfire extreme behaviour in Southern Europe.

    NASA Astrophysics Data System (ADS)

    Gaetani, Francesco; Baptiste Filippi, Jean; Simeoni, Albert; D'Andrea, Mirko

    2010-05-01

    Haines Index (HI) was developed by USDA Forest Service to measure the atmosphere's contribution to the growth potential of a wildfire. The Haines Index combines two atmospheric factors that are known to have an effect on wildfires: Stability and Dryness. As operational tools, HI proved its ability to predict plume dominated high intensity wildfires. However, since HI does not take into account the fuel continuity, composition and moisture conditions and the effects of wind and topography on fire behaviour, its use as forecasting tool should be carefully considered. In this work we propose the use of HI, predicted from HR Limited Area Model forecasts, coupled with a Fire Weather model (i.e., RISICO system) fully operational in Italy since 2003. RISICO is based on dynamic models able to represent in space and in time the effects that environment and vegetal physiology have on fuels and, in turn, on the potential behaviour of wildfires. The system automatically acquires from remote databases a thorough data-set of input information both of in situ and spatial nature. Meteorological observations, radar data, Limited Area Model weather forecasts, EO data, and fuel data are managed by a Unified Interface able to process a wide set of different data. Specific semi-physical models are used in the system to simulate the dynamics of the fuels (load and moisture contents of dead and live fuel) and the potential fire behaviour (rate of spread and linear intensity). A preliminary validation of this approach will be provided with reference to Sardinia and Corsica Islands, two major islands of the Mediterranean See frequently affected by extreme plume dominated wildfires. A time series of about 3000 wildfires burnt in Sardinia and Corsica in 2007 and 2008 will be used to evaluate the capability of HI coupled with the outputs of the Fire Weather model to forecast the actual risk in time and in space.

  14. 78 FR 22170 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Service. [FR Doc. 2013-07500 Filed 4-12-13; 8:45 am] BILLING CODE 4910-13-P ... Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes AGENCY: Federal Aviation Administration... airworthiness directive (AD) for Diamond Aircraft Industries GmbH Models DA 42, DA 42 M-NG, and DA 42NG...

  15. 78 FR 37150 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... Deutschland GmbH (ECD) Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...): Eurocopter Deutschland GmbH (ECD): Docket No. FAA-2013-0519; Directorate Identifier 2010-SW-068-AD. (a... European Aviation Safety Agency AD No. 2010-0128, dated June 25, 2010. (h) Subject Joint Aircraft Service...

  16. 76 FR 76293 - Airworthiness Directives; BRP-Powertrain GmbH & Co. KG Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Airworthiness Directives; BRP-Powertrain GmbH & Co. KG Reciprocating Engines AGENCY: Federal Aviation... directive (AD) for BRP- Powertrain GmbH & Co. KG Rotax 912 F2, 912 F3, 912 F4, 912 S2, 912 S3, 912 S4, 914...-Powertrain GmbH & Co. KG, Rotax Aircraft Engines, Mandatory Alert Service Bulletins (ASB) Nos. ASB-912-059...

  17. 78 FR 52872 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... certain 328 Support Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild...

  18. 77 FR 12163 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Airplanes AGENCY: Federal Aviation Administration (FAA... directive (AD) for all 328 Support Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH...

  19. 76 FR 42031 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 and -300 Airplanes AGENCY: Federal Aviation... 328 Support Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild...

  20. 77 FR 54800 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... airworthiness directive (AD) for certain Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG... products. The MCAI states: During conversion of a DA 42 to a DA 42 NG, voids were detected in the adhesive... the following Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG airplanes...

  1. 78 FR 1728 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... scheduled maintenance, whichever occurs first, do the following. (1) Remove the oil filler plug and check... Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines AGENCY: Federal Aviation... all Thielert Aircraft Engines GmbH (TAE) TAE 125-02-99 and TAE 125-02-114 reciprocating engines. This...

  2. 78 FR 1733 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines AGENCY: Federal Aviation... (AD) for all Thielert Aircraft Engines GmbH models TAE 125-01, TAE 125-02- 99, and TAE 125-02-114 reciprocating engines. That AD currently requires installation of full-authority digital electronic control...

  3. 75 FR 75159 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-02

    ... Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 and -300 Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... Services GmbH, Global Support Center, P.O. Box 1252, D-82231 Wessling, Federal Republic of Germany...

  4. 76 FR 54145 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. [[Page 54146... Services GmbH, Global Support Center, P.O. Box 1252, D-82231 Wessling, Federal Republic of Germany...

  5. 76 FR 82110 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines AGENCY: Federal Aviation...) for Thielert Aircraft Engines GmbH models TAE 125-02-99 and TAE 125-01 reciprocating engines. That AD... flight hours to within 600 flight hours for TAE 125-01 reciprocating engines. This AD was prompted by the...

  6. 78 FR 26241 - Airworthiness Directives; Diamond Aircraft Industries GmbH Powered Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Airworthiness Directives; Diamond Aircraft Industries GmbH Powered Gliders AGENCY: Federal Aviation... directive (AD) for certain Diamond Aircraft Industries GmbH Models HK 36 R, HK 36 TS, and HK 36 TTS powered... removing the Model H-36 from the Applicability. This AD was prompted by reports of installation of an...

  7. 76 FR 19721 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Services GmbH (Type Certificate Previously Held by AvCraft Aerospace GmbH; Fairchild Dornier GmbH; Dornier Luftfahrt GmbH) Model 328-100 and -300 Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... information identified in this proposed AD, contact 328 Support Services GmbH, Global Support Center, P.O. Box...

  8. 76 FR 68636 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Reciprocating Engines AGENCY: Federal Aviation... airworthiness directive (AD) for Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125- 02-99 reciprocating engines. That AD currently requires replacement of certain part numbers (P/Ns) and serial numbers...

  9. 77 FR 3090 - Airworthiness Directives; BRP-POWERTRAIN GMBH & CO KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... Airworthiness Directives; BRP--POWERTRAIN GMBH & CO KG Rotax Reciprocating Engines AGENCY: Federal Aviation... BRP-- POWERTRAIN GMBH & CO KG Rotax 914 F2, 914 F3, and 914 F4 reciprocating engines. This AD results... of fuel pressure regulators, part number (P/N) 887130, installed on Rotax 914 F series engines, which...

  10. Detection of mycobacteria in aquarium fish in Slovenia by culture and molecular methods.

    PubMed

    Pate, M; Jencic, V; Zolnir-Dovc, M; Ocepek, M

    2005-04-06

    Thirty-five aquarium fish were investigated for the presence of mycobacteria by culture and molecular methods. The following species were examined: goldfish Carassius auratus auratus, guppy Poecilia reticulata, 4 three-spot gourami Trichogaster trichopterus, dwarf gourami Colisa lalia, Siamese fighting fish Betta splendens, freshwater angelfish Pterophyllum scalare, African cichlid fish Cichlidae spp., cichlid fish Microgeophagus altispinosus, cichlid fish Pseudotropheus lombardoi, blue streak hap Labidochromis caeruleus, sterlet Acipenser ruthenus, southern platyfish Xiphophorus maculatus, and catfish Corydoras spp. Isolates of mycobacteria were obtained in 29 cases (82.9%). Two specimens were positive using Ziehl-Neelsen (ZN) staining, but the cultivation failed. Four specimens were both ZN- and culture-negative. On the basis of GenoType Mycobacterium assay (Hain Life-science) and restriction enzyme analysis of the amplified products (PCR-RFLP), 23 isolates (79.3%) were identified: 7 as Mycobacterium fortuitum, 6 as M. gordonae, 6 as M. marinum, 3 as M. chelonae, and 1 as M. peregrinum. Five isolates remained unidentified (Mycobacterium spp.). One case probably represented a mixed infection (M. marinum/M. fortuitum). Since M. marinum infections are also detected in humans, the significance of mycobacteria in aquarium fish should not be overlooked.

  11. 76 FR 23169 - Airworthiness Directives; DG Flugzeugbau GmbH Glaser-Dirks Model DG-808C Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... Directives; DG Flugzeugbau GmbH Glaser-Dirks Model DG-808C Gliders AGENCY: Federal Aviation Administration... applies to DG Flugzeugbau GmbH Glaser-Dirks Models DG-808C gliders, serial numbers 8-316 B 216 X 1 through...

  12. 75 FR 52292 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for all Diamond Aircraft Industries GmbH Models DA 40 and DA 40F... received information from Diamond Aircraft Industries GmbH that the Models DA 40 and DA 40F airplanes have...

  13. 78 FR 70327 - TÜV SÜD Product Services GmbH: Request for Renewal of Recognition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ...[Uuml]V S[Uuml]D Product Services GmbH: Request for Renewal of Recognition AGENCY: Occupational Safety and Health Administration (OSHA), Labor ACTION: Notice. SUMMARY: This notice announces T[Uuml]V S[Uuml..., or denying the renewal of recognition. T[Uuml]V S[Uuml]D Product Services GmbH (TUVPSG) initially...

  14. 78 FR 39339 - Importer of Controlled Substances; Notice of Registration; SA INTL GMBH C/O., Sigma Aldrich Co., LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... Registration; SA INTL GMBH C/O., Sigma Aldrich Co., LLC By Notice dated March 20, 2013, and published in the Federal Register on March 28, 2013, 78 FR 19015, SA INTL GMBH C/O., Sigma Aldrich Co. LLC., 3500 Dekalb... registration of SA INTL GMBH C/O., Sigma Aldrich Co. LLC., to import the basic classes of controlled substances...

  15. 76 FR 32019 - Notice of Receipt of Petition for Decision That Nonconforming 2008-2010 M&V GmbH Siegmar Fzb...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ...-0062; Notice 1] Notice of Receipt of Petition for Decision That Nonconforming 2008-2010 M&V GmbH..., DOT. ACTION: Notice of receipt of petition for decision that nonconforming 2008-2010 M&V GmbH Siegmar... Highway Traffic Safety Administration (NHTSA) of a petition for a decision that 2008-2010 M&V GmbH Siegmar...

  16. 77 FR 47106 - Manufacturer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co. LLC Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on May 2, 2012, SA INTL GMBH C/O., Sigma Aldrich Co. LLC., 3500...

  17. 77 FR 74508 - Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Statement for the Ring of Fire Resource Management Plan--Haines Planning Area, Alaska AGENCY: Bureau of Land.../Draft Environmental Impact Statement (EIS) for the Ring of Fire RMP for the Haines Planning Area and by... Fire RMP-- Haines Planning Area Amendment by any of the following methods: Email: [email protected

  18. 77 FR 64911 - Fluoxastrobin; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ..., liver; hog, fat; hog, meat byproducts; and rice, grain. Arysta LifeScience, North America, LLC... (PP 1F7897) by Arysta LifeScience, North America, LLC, 15401 Weston Pkwy., Suite 150, Cary, NC 27513... Arysta LifeScience, North America LLC, the registrant, which is available in the docket, http:[sol][sol...

  19. 77 FR 69840 - Iodomethane; Notice of Receipt of Request to Voluntarily Cancel Iodomethane Pesticide...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... that as of January 1, 2013, Arysta LifeScience North America, LLC (Arysta) will not sell or distribute... for Cancellation Registration No. Product name Company 66330-43 Midas 98:2 Arysta LifeScience North America, LLC. 66330-44 Iodomethane Technical. Arysta LifeScience North America, LLC. 66330-57 Midas 50:50...

  20. 78 FR 48795 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ..., contact BRP- Powertrain GmbH & Co KG, Welser Strasse 32, A-4623 Gunskirchen, Austria; Internet: http://www..., A-4623 Gunskirchen, Austria; Internet: http://www.FLYROTAX.com . (4) You may view this service...

  1. 77 FR 4217 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... sensitivity of friction disk Part Number (P/N) 05-7211- K010201 against possible misalignment of gearbox and..., Thielert Aircraft Engines GmbH has developed a new friction disk. We issued a notice of proposed rulemaking... all TAE 125-02-99 and TAE 125-02-114 reciprocating engines, replacing the friction disk, P/N 05- 7211...

  2. 75 FR 16017 - Cloquintocet-mexyl; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...-quinolinoxyacetic acid) on wheat forage, wheat grain, wheat hay, and wheat straw. Arysta LifeScience North America...-5805. II. Petition for Tolerance EPA has received a petition from Arysta LifeScience North America, LLC... filing of the above-referenced pesticide petition (PP 9E7592) by Arysta LifeScience North America, LLC...

  3. Keeping Haines Real - Or Really Changing Haines?

    Treesearch

    Brian E. Potter; Dan Borsum; Don Haines

    2002-01-01

    Most incident command teams can handle low- to moderate-intensity fires with few unanticipated problems. However, high-intensity situations, especially the plume-dominated fires that often develop when winds are low and erratic behavior is unexpected, can create dangerous situations even for well-trained, experienced fire crews (Rothermel 1991). Plume-dominated fires...

  4. 78 FR 19015 - Importer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co. LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co. LLC Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on February 1, 2013, SA INTL GMBH C/O., Sigma Aldrich Co. LLC., 3500 Dekalb...

  5. Three year evaluation of Xpert MTB/RIF in a low prevalence tuberculosis setting: A Scottish perspective.

    PubMed

    Parcell, Benjamin J; Jarchow-MacDonald, Anna A; Seagar, Amie-Louise; Laurenson, Ian F; Prescott, Gordon J; Lockhart, Michael

    2017-05-01

    Xpert MTB/RIF (Cepheid) is a rapid molecular assay shown to be sensitive and specific for pulmonary tuberculosis (TB) diagnosis in highly endemic countries. We evaluated its diagnostic performance in a low TB prevalence setting, examined rifampicin resistance detection and quantitative capabilities predicting graded auramine microscopy and time to positivity (TTP) of culture. Xpert MTB/RIF was used to test respiratory samples over a 3 year period. Samples underwent graded auramine microscopy, solid/liquid culture, in-house IS6110 real-time PCR, and GenoType MTBDRplus (HAIN Lifescience) to determine rifampicin and/or isoniazid resistance. A total of 2103 Xpert MTB/RIF tests were performed. Compared to culture sensitivity was 95.8%, specificity 99.5%, positive predictive value (PPV) 82.1%, and negative predictive value (NPV) 99.9%. A positive correlation was found between auramine microscopy grade and Xpert MTB/RIF assay load. We found a clear reduction in the median TTP as Xpert MTB/RIF assay load increased. Rifampicin resistance was detected. Xpert MTB/RIF was rapid and accurate in diagnosing pulmonary TB in a low prevalence area. Rapid results will influence infection prevention and control and treatment measures. The excellent NPV obtained suggests further work should be carried out to assess its role in replacing microscopy. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  6. 77 FR 16968 - Airworthiness Directives; Burkhart GROB Luft- und Raumfahrt GmbH Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... verbal contact we receive about this proposed AD. Discussion The European Aviation Safety Agency (EASA...-200. (h) Related Information Refer to MCAI European Aviation Safety Agency (EAS) AD No. 2012- 0027...- und Raumfahrt GmbH Powered Sailplanes AGENCY: Federal Aviation Administration (FAA), Department of...

  7. 77 FR 32887 - Airworthiness Directives; Burkhart GROB Luft- und Raumfahrt GmbH Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... Airworthiness Directives; Burkhart GROB Luft- und Raumfahrt GmbH Powered Sailplanes AGENCY: Federal Aviation... seaside and therefore exposed to a salty environment, causing the excessive corrosion. This condition, if... Programs,'' describes in more detail the scope of the Agency's authority. We are issuing this rulemaking...

  8. 76 FR 31457 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes AGENCY: Federal Aviation... reportedly found on DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard maintenance... DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard maintenance. Depending on...

  9. 76 FR 14346 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... Industries GmbH Model DA 42 Airplanes AGENCY: Federal Aviation Administration (FAA), Department of... been reportedly found on DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard... condition for the specified products. The MCAI states: Cracks have been reportedly found on DA 42 Main...

  10. 75 FR 16822 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... FURTHER INFORMATION CONTACT: Kathy Ezzell, Department of Housing and Urban Development, 451 Seventh Street... ALASKA Dalton-Cache Border Station Mile 42 Haines Highway Haines AK 99827 Landholding Agency: GSA...

  11. 76 FR 253 - Airworthiness Directives; ROLLADEN-SCHNEIDER Flugzeugbau GmbH Model LS6 Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... Airworthiness Directives; ROLLADEN-SCHNEIDER Flugzeugbau GmbH Model LS6 Gliders AGENCY: Federal Aviation... condition does not exist in the Model LS6-c gliders. FAA's Determination We are issuing this AD rescission... Model LS6 glider, and the unsafe condition described previously is not likely to exist or develop in the...

  12. 77 FR 66534 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... Rotax 912 F2; 912 F3; 912 F4; 912 S2; 912 S3; and 912 S4 reciprocating engines. The word ``not'' was...-Powertrain GmbH & Co KG Rotax 912 F2; 912 F3; 912 F4; 912 S2; 912 S3; and 912 S4 reciprocating engines. As...

  13. Testing of the high accuracy inertial navigation system in the Shuttle Avionics Integration Lab

    NASA Technical Reports Server (NTRS)

    Strachan, Russell L.; Evans, James M.

    1991-01-01

    The description, results, and interpretation is presented of comparison testing between the High Accuracy Inertial Navigation System (HAINS) and KT-70 Inertial Measurement Unit (IMU). The objective was to show the HAINS can replace the KT-70 IMU in the space shuttle Orbiter, both singularly and totally. This testing was performed in the Guidance, Navigation, and Control Test Station (GTS) of the Shuttle Avionics Integration Lab (SAIL). A variety of differences between the two instruments are explained. Four, 5 day test sessions were conducted varying the number and slot position of the HAINS and KT-70 IMUs. The various steps in the calibration and alignment procedure are explained. Results and their interpretation are presented. The HAINS displayed a high level of performance accuracy previously unseen with the KT-70 IMU. The most significant improvement of the performance came in the Tuned Inertial/Extended Launch Hold tests. The HAINS exceeded the 4 hr specification requirement. The results obtained from the SAIL tests were generally well beyond the requirements of the procurement specification.

  14. 78 FR 95 - Notice of Receipt of Requests for Amendments To Delete Uses in Certain Pesticide Registrations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ....S.A. Corporation, 1600 Riviera Ave., Suite 200, Walnut Creek, CA 94596. 66330 Arysta LifeScience..., FL 33881-9432. 85904 Arysta LifeScience America, Inc., 1450 Broadway, 7th Floor, New York, NY 10018...

  15. 78 FR 13295 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ...: [email protected] . 5. PP 2F8130. (EPA-HQ-OPP-2012-0576). Arysta LifeScience North America, LLC...-2012-0576). Arysta LifeScience North America, LLC, requests to revise the tolerances in 40 CFR 180.609...

  16. 75 FR 17084 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Model TAE 125-01 Reciprocating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... Differences (f) None. Alternative Methods of Compliance (AMOCs) (g) The Manager, Engine Certification Office... Engines GmbH (TAE) Model TAE 125-01 Reciprocating Engines AGENCY: Federal Aviation Administration (FAA... 02-7250-18300R5, may cause a blow-by gas pressure increase inside the crankcase of the engine in...

  17. Geochemical reanalysis of historical U.S. Geological Survey sediment samples from the Haines area, Juneau and Skagway quadrangles, southeast Alaska

    USGS Publications Warehouse

    Werdon, Melanie B.; Granitto, Matthew; Azain, Jaime S.

    2015-01-01

    The State of Alaska’s Strategic and Critical Minerals (SCM) Assessment project, a State-funded Capital Improvement Project (CIP), is designed to evaluate Alaska’s statewide potential for SCM resources. The SCM Assessment is being implemented by the Alaska Division of Geological & Geophysical Surveys (DGGS), and involves obtaining new airborne-geophysical, geological, and geochemical data. As part of the SCM Assessment, thousands of historical geochemical samples from DGGS, U.S. Geological Survey (USGS), and U.S. Bureau of Mines archives are being reanalyzed by DGGS using modern, quantitative, geochemical-analytical methods. The objective is to update the statewide geochemical database to more clearly identify areas in Alaska with SCM potential. The USGS is also undertaking SCM-related geologic studies in Alaska through the federally funded Alaska Critical Minerals cooperative project. DGGS and USGS share the goal of evaluating Alaska’s strategic and critical minerals potential and together created a Letter of Agreement (signed December 2012) and a supplementary Technical Assistance Agreement (#14CMTAA143458) to facilitate the two agencies’ cooperative work. Under these agreements, DGGS contracted the USGS in Denver to reanalyze historical USGS sediment samples from Alaska. For this report, DGGS funded reanalysis of 212 historical USGS sediment samples from the statewide Alaska Geochemical Database Version 2.0 (AGDB2; Granitto and others, 2013). Samples were chosen from the Chilkat, Klehini, Tsirku, and Takhin river drainages, as well as smaller drainages flowing into Chilkat and Chilkoot Inlets near Haines, Skagway Quadrangle, Southeast Alaska. Additionally some samples were also chosen from the Juneau gold belt, Juneau Quadrangle, Southeast Alaska (fig. 1). The USGS was responsible for sample retrieval from the National Geochemical Sample Archive (NGSA) in Denver, Colorado through the final quality assurance/quality control (QA/QC) of the geochemical

  18. 2. Historic American Buildings Survey, August, 1971 STREETSCAPE SHOWING EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, August, 1971 STREETSCAPE SHOWING EAST (FRONT) ELEVATIONS OF HAINES BROTHERS BRICK STORE (FAR RIGHT), ORTH BUILDING, BRUNNER BROTHERS STORE, AND NORTH (FRONT) ELEVATION OF CITY HALL (FAR LEFT). - Haines Brothers Brick Store, 110 South Oregon Street, Jacksonville, Jackson County, OR

  19. Lattice Boltzmann simulations of supercritical CO2-water drainage displacement in porous media: CO2 saturation and displacement mechanism.

    PubMed

    Yamabe, Hirotatsu; Tsuji, Takeshi; Liang, Yunfeng; Matsuoka, Toshifumi

    2015-01-06

    CO2 geosequestration in deep aquifers requires the displacement of water (wetting phase) from the porous media by supercritical CO2 (nonwetting phase). However, the interfacial instabilities, such as viscous and capillary fingerings, develop during the drainage displacement. Moreover, the burstlike Haines jump often occurs under conditions of low capillary number. To study these interfacial instabilities, we performed lattice Boltzmann simulations of CO2-water drainage displacement in a 3D synthetic granular rock model at a fixed viscosity ratio and at various capillary numbers. The capillary numbers are varied by changing injection pressure, which induces changes in flow velocity. It was observed that the viscous fingering was dominant at high injection pressures, whereas the crossover of viscous and capillary fingerings was observed, accompanied by Haines jumps, at low injection pressures. The Haines jumps flowing forward caused a significant drop of CO2 saturation, whereas Haines jumps flowing backward caused an increase of CO2 saturation (per injection depth). We demonstrated that the pore-scale Haines jumps remarkably influenced the flow path and therefore equilibrium CO2 saturation in crossover domain, which is in turn related to the storage efficiency in the field-scale geosequestration. The results can improve our understandings of the storage efficiency by the effects of pore-scale displacement phenomena.

  20. 75 FR 39803 - Airworthiness Directives; Thielert Aircraft Engines GmbH Model TAE 125-01 Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Model TAE 125-01 Reciprocating Engines AGENCY: Federal...-18300R5, may cause a blow-by gas pressure increase inside the crankcase of the engine in excess of the oil seal design pressure limits. Leaking engine oil may adversely affect the gearbox clutch or the engine...

  1. 75 FR 24694 - Pesticide Products; Registration Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    .... File Symbol: 66330-UNG. Applicant: Arysta LifeScience, LLC, 15401 Westin Parkway, Suite 150, Cary, NC...%. Proposed classification/Use: Manufacturing use product. File Symbol: 66330-UNU. Applicant: Arysta LifeScience, LLC 15401 Westin Parkway, Suite 150, Cary, NC 27513. Product name: Kasumin 2L. Active ingredient...

  2. 76 FR 57034 - Pesticide Products; Receipt of Applications To Register New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ...-OPP-2009-0677. Company Name and Address: Arysta LifeScience, North America LLC, 15401 Weston Parkway...: 66330-45 and 66330-46. Docket Number: EPA- HQ-OPP-2011-0641. Company Name and Address: Arysta LifeScience North America LLC, 15401 Weston Parkway, Suite 150, Cary, NC 27513. Active Ingredient...

  3. Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of micro-organisms in the routine clinical microbiology laboratory.

    PubMed

    Wattal, C; Oberoi, J K; Goel, N; Raveendran, R; Khanna, S

    2017-05-01

    The study evaluates the utility of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) Vitek MS for identification of microorganisms in the routine clinical microbiology laboratory. From May 2013 to April 2014, microbial isolates recovered from various clinical samples were identified by Vitek MS. In case of failure to identify by Vitek MS, the isolate was identified using the Vitek 2 system (bioMerieux, France) and serotyping wherever applicable or otherwise by nucleic acid-mediated methods. All the moulds were identified by Lactophenol blue mounts, and mycobacterial isolates were identified by molecular identification systems including AccuProbe (bioMerieux, France) or GenoType Mycobacterium CM (Hain Lifescience, Germany). Out of the 12,003 isolates, the Vitek MS gave a good overall ID at the genus and or species level up to 97.7% for bacterial isolates, 92.8% for yeasts and 80% for filamentous fungi. Of the 26 mycobacteria tested, only 42.3% could be identified using the Saramis RUO (Research Use Only) database. VITEK MS could not identify 34 of the 35 yeast isolates identified as C. haemulonii by Vitek 2. Subsequently, 17 of these isolates were identified as Candida auris (not present in the Vitek MS database) by 18S rRNA sequencing. Using these strains, an in-house superspectrum of C. auris was created in the VITEK MS database. Use of MALDI-TOF MS allows a rapid identification of aerobic bacteria and yeasts in clinical practice. However, improved sample extraction protocols and database upgrades with inclusion of locally representative strains is required, especially for moulds.

  4. Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.

    PubMed

    Aung, Wah Wah; Ei, Phyu Win; Nyunt, Wint Wint; Swe, Thyn Lei; Lwin, Thandar; Htwe, Mi Mi; Kim, Kyung Jun; Lee, Jong Seok; Kim, Chang Ki; Cho, Sang Nae; Song, Sun Dae; Chang, Chulhun L

    2015-09-01

    Tuberculosis (TB) is one of the most serious health problems in Myanmar. Because TB drug resistance is associated with genetic mutation(s) relevant to responses to each drug, genotypic methods for detecting these mutations have been proposed to overcome the limitations of classic phenotypic drug susceptibility testing (DST). We explored the current estimates of drug-resistant TB and evaluated the usefulness of genotypic DST in Myanmar. We determined the drug susceptibility of Mycobacterium tuberculosis isolated from sputum smear-positive patients with newly diagnosed pulmonary TB at two main TB centers in Myanmar during 2013 by using conventional phenotypic DST and the GenoType MTBDRplus assay (Hain Lifescience, Germany). Discrepant results were confirmed by sequencing the genes relevant to each type of resistance (rpoB for rifampicin; katG and inhA for isoniazid). Of 191 isolates, phenotypic DST showed that 27.7% (n=53) were resistant to at least one first-line drug and 20.9% (n=40) were resistant to two or more, including 18.3% (n=35) multidrug-resistant TB (MDR-TB) strains. Monoresistant strains accounted for 6.8% (n=13) of the samples. Genotypic assay of 189 isolates showed 17.5% (n=33) MDR-TB and 5.3% (n=10) isoniazid-monoresistant strains. Genotypic susceptibility results were 99.5% (n=188) concordant and agreed almost perfectly with phenotypic DST (kappa=0.99; 95% confidence interval 0.96-1.01). The results highlight the burden of TB drug resistance and prove the usefulness of the genotypic DST in Myanmar.

  5. Note on Conditional Compilation in Standard ML

    DTIC Science & Technology

    1993-06-01

    eOmputer-Science No-te on Coridhitiom Cominliati"I~n Standard ML1 Nicholas Haines Edoardo Biagioni Robert Hiarper mom Brian G. Mimnes June 1993 CMU...CS-93. 11 TIC ELECTE f 00..7733 %goo~~OO Note on Conditioual Compilation in Standard ML Nicholas Haines Edoardo Biagioni Robert Harper Brian G. Milnes

  6. Oral Traditions, Changing Rural Landscapes, and Science Education

    ERIC Educational Resources Information Center

    Stapleton, Sarah Riggs

    2017-01-01

    This forum response extends the argument made by Avery and Hains that oral traditions can be useful for including the cultures and contexts of rural areas within science instruction. To buttress the oral expressions presented in Avery and Hains, I compare oral expressions of a second rural area, 600 miles to the South, in Eastern North Carolina. I…

  7. Evidence of Cold Climate Slope Processes from the New Jersey Coastal Plain: Debris Flow Stratigraphy at Haines Corner, Camden County, New Jersey

    USGS Publications Warehouse

    Newell, Wayne L.

    2005-01-01

    Excavations through surficial deposits across the New Jersey Coastal Plain commonly reveal homogenized surficial sediments, deformed sedimentary structures, chaotically rearranged bed-forms, and wedge-shaped cracks filled with sand from the top-most layers of extant soil profiles. As a whole, these abundant, broadly distributed phenomena are best explained as artifacts of an era of frozen ground during the last Pleistocene glacial maximum. Vigorous freeze-thaw processes and abundant seasonal rainfall created a landscape of low relief covered by highly mobile surficial deposits. The surficial deposits are at grade into broad, flat bottomed valleys now drained by small, tightly meandering, under-fit streams. Modern fluvial, aeolian, and slope processes are ineffectual in either creating or modifying these landscapes. One particularly brief exposure of complex slope deposits was documented at Haines Corner, Camden County, during the field work (1986) for the Surficial Geologic Map of southern and central New Jersey. The exposure, now presented and interpreted here, provides previously unavailable details of a system of freeze-thaw driven processes that unfolded upon a frozen, impermeable substrate 80 miles south of the southern margin of the Wisconsinan glacial advance to Long Island, N.Y. At the time of these extreme processes, the presently sub-aerial New Jersey Coastal Plain was not proximal to moderating effects of the Atlantic Ocean, being about 100 miles inland and 300 feet above the lowered sea level. Current studies of analogous deposits across the mid-Atlantic Coastal Plain now benefit from dating techniques that were not available during the geologic mapping field work (1985-'92). During the mapping in New Jersey, hundreds of exposures failed to produce datable carbon remains within the stratigraphy of the surficial deposits. Recently reported TL dates from wind-blown sand filling frost wedges, exposed elsewhere in New Jersey, indicate that the widely

  8. 75 FR 54462 - Airworthiness Directives; Bombardier-Rotax GmbH 912 F Series and 912 S Series Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Airworthiness Directives; Bombardier-Rotax GmbH 912 F Series and 912 S Series Reciprocating Engines AGENCY... result in exceeding of the fuel pressure and might cause engine malfunction and/or massive fuel leakage... engine malfunction or a massive fuel leak. These conditions could cause loss of control of the airplane...

  9. 75 FR 75868 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal... of the Thielert Engine Owners Group commented that the Model DA 42 has the same door design and the same unsafe condition. He recommended that the AD also apply to the Model DA 42. The FAA has discussed...

  10. 75 FR 17632 - Airworthiness Directives; Bombardier-Rotax GmbH Type 912 F, 912 S, and 914 F Series Reciprocating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... Bombardier-Rotax engines in Europe. Differences Between the Proposed AD and the Service Information Rotax... GmbH Type 912 F, 912 S, and 914 F Series Reciprocating Engines AGENCY: Federal Aviation Administration... and 914 F series reciprocating engines. That AD currently requires initial and repetitive visual...

  11. 77 FR 50162 - Importer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co., LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; SA INTL GMBH C/O., Sigma Aldrich Co., LLC Correction In notice document 2012-19191 appearing on pages 47106-47108 in the issue of Tuesday, August 7, 2012, make the following corrections: 1. On page...

  12. 75 FR 52240 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ..., 2010, or SB No. TM TAE 125-1011 P1, dated June 9, 2010, into any engine. FAA AD Differences (f) This AD... Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02-99 Reciprocating Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule; request for comments...

  13. 76 FR 64289 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) TAE 125-02-99 and TAE 125-02-114...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Engines GmbH (TAE) TAE 125-02-99 and TAE 125-02-114 Reciprocating Engines AGENCY: Federal Aviation... unsafe condition on an aviation product. The MCAI describes the unsafe condition as: In-flight engine shutdown incidents have been reported on aeroplanes equipped with TAE 125 engines. Preliminary...

  14. 75 FR 61046 - Airworthiness Directives; Bombardier-Rotax GmbH Type 912 F, 912 S, and 914 F Series Reciprocating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... identified in this AD from BRP-Rotax GmbH & Co. KG, Welser Strasse 32, A-4623 Gunskirchen, Austria. The... looking at the S/ N in the area indicated by XXX, following ``Made in Austria,'' as shown on Figure 2 of... 32, A-4623 Gunskirchen, Austria, or go to rotax-aircraft-engines.com for a copy of this service...

  15. 75 FR 66342 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... difference is to ensure that the compliance requirements for all engines in paragraph (e)(1) above are... Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114 Reciprocating Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM...

  16. Potential industrial sites in the Lynn Canal area, Alaska

    USGS Publications Warehouse

    Johnson, Arthur; Twenhofel, William Stephens

    1953-01-01

    Full development of a proposal to divert the headwaters of the Yukon River drainage from Canada into the Taiya River valley of Alaska would make available more than a half million kilowatts of electrical energy. Utilization of this block of power, for which there is at present no local market, will require an industrial and community development of appreciable magnitude. Suitable sites for industrial and community development near the proposed power source are limited because of the extremely rugged and mountainous terrain of the Lynn Canal area. This report considers potential industrial areas at Skagway, Taiya River, Ferebee River, Lutak Inlet, Haines and vicinity, Klukwan and vicinity, Haines to Klukwan along the Haines cutoff, Berners Bay, and Juneau and vicinity. The factors considered in their evaluation are topography, geology, climate, water supply, transportation facilities, and transmission-line routes from the source of power.

  17. Power Scaling of CW and Pulsed IR and Mid-IR OPSLs (Postprint)

    DTIC Science & Technology

    2013-01-01

    T. J. Rotter, G. Balakrishnan, and C. Hains University of New Mexico S. W . Koch, W . Stolz, and B . Kunert University of Marburg...Balakrishnan, and C. Hains (University of New Mexico ) S. W . Koch, W . Stolz, and B . Kunert (University of Marburg) 5d. PROJECT NUMBER 2002 5e. TASK...Yarboroughb, T. J Rotterc, G. Balakrishnanc, C. Hainsc, S.W. Kochd, W . Stolzd, B . Kunertd,R. Bedforde aNonlinear Control Strategies Inc, 3542 N

  18. 76 FR 9963 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114 Reciprocating Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a... condition, if not corrected, could lead to in-flight cases of engine shutdown. We are issuing this AD to...

  19. 77 FR 53154 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-02-99 and TAE 125-02-114 Reciprocating...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all TAE 125-02-99 and TAE 125-02-114... 125-02-99 engine. This proposed AD would require inspection of the oil filler plug vent hole at the...

  20. Graphical support for comprehending science texts: The contributions of diagram design and text directives

    NASA Astrophysics Data System (ADS)

    McTigue, Erin M.

    The present study examined the combined effect of diagram design and text directives on the comprehension of explanatory science texts for middle school readers. Three types of diagram designs were compared. Each design contained the same graphical representation of a cycle but differed in the labels. The labels indicated either the (a) parts of the, cycle, (b) steps of the cycle, or (c) both the parts and steps. Additionally, there were two conditions of text, both with and without embedded directives. The directives guided the reader to the diagram to help readers integrate the two sources of information. Finally, each of the 189 sixth grade participants read two texts---a life-science text and a physical-science text. Results indicated that for the life-science text both the parts diagrams and the steps diagrams facilitated the readers' comprehension, but that the parts & steps diagram did not. Overall, the directives assisted readers in the life-science text, when they were viewing the complex diagrams: the steps diagram, and the parts & steps diagrams, but not the parts diagram. Directives also helped girls who were reading at the below- and on-grade level, but not the girls reading above-grade level. Neither the diagrams nor directives facilitated comprehension of the physical science text. There was a gender difference favoring boys on the physical science but no gender difference on the life-science text.

  1. 76 FR 12627 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG Airplanes AGENCY: Federal Aviation Administration (FAA... on Diamond aeroplanes, the majority of which were DA 40. In additional, at least 18 doors have been... conditions) while the aeroplane was parked. All DA 40 and DA 42 aeroplanes have a system installed that...

  2. More Life-Science Experiments For Spacelab

    NASA Technical Reports Server (NTRS)

    Savage, P. D., Jr.; Dalton, B.; Hogan, R.; Leon, H.

    1991-01-01

    Report describes experiments done as part of Spacelab Life Sciences 2 mission (SLS-2). Research planned on cardiovascular, vestibular, metabolic, and thermal responses of animals in weightlessness. Expected to shed light on effects of prolonged weightlessness on humans.

  3. Solar Water Heater

    NASA Technical Reports Server (NTRS)

    1993-01-01

    As a Jet Propulsion Laboratory (JPL) scientist Dr. Eldon Haines studied the solar energy source and solar water heating. He concluded he could build a superior solar water heating system using the geyser pumping principle. He resigned from JPL to develop his system and later form Sage Advance Corporation to market the technology. Haines' Copper Cricket residential system has no moving parts, is immune to freeze damage, needs no roof-mounted tanks, and features low maintenance. It provides 50-90 percent of average hot water requirements. A larger system, the Copper Dragon, has been developed for commercial installations.

  4. Safety of the lateral trauma position in cervical spine injuries: a cadaver model study.

    PubMed

    Hyldmo, P K; Horodyski, M B; Conrad, B P; Dubose, D N; Røislien, J; Prasarn, M; Rechtine, G R; Søreide, E

    2016-08-01

    Endotracheal intubation is not always an option for unconscious trauma patients. Prehospital personnel are then faced with the dilemma of maintaining an adequate airway without risking deleterious movement of a potentially unstable cervical spine. To address these two concerns various alternatives to the classical recovery position have been developed. This study aims to determine the amount of motion induced by the recovery position, two versions of the HAINES (High Arm IN Endangered Spine) position, and the novel lateral trauma position (LTP). We surgically created global cervical instability between the C5 and C6 vertebrae in five fresh cadavers. We measured the rotational and translational (linear) range of motion during the different maneuvers using an electromagnetic tracking device and compared the results using a general linear mixed model (GLMM) for regression. In the recovery position, the range of motion for lateral bending was 11.9°. While both HAINES positions caused a similar range of motion, the motion caused by the LTP was 2.6° less (P = 0.037). The linear axial range of motion in the recovery position was 13.0 mm. In comparison, the HAINES 1 and 2 positions showed significantly less motion (-5.8 and -4.6 mm, respectively), while the LTP did not (-4.0 mm, P = 0.067). Our results indicate that in unconscious trauma patients, the LTP or one of the two HAINES techniques is preferable to the standard recovery position in cases of an unstable cervical spine injury. © 2016 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

  5. Identifying ELIXIR Core Data Resources

    PubMed Central

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2017-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR’s sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure. PMID:27803796

  6. Identifying ELIXIR Core Data Resources.

    PubMed

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2016-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR's sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure.

  7. Comparative evaluation of the identification of rapidly growing non-tuberculous mycobacteria by mass spectrometry (MALDI-TOF MS), GenoType Mycobacterium CM/AS assay and partial sequencing of the rpoβ gene with phylogenetic analysis as a reference method.

    PubMed

    Costa-Alcalde, José Javier; Barbeito-Castiñeiras, Gema; González-Alba, José María; Aguilera, Antonio; Galán, Juan Carlos; Pérez-Del-Molino, María Luisa

    2018-06-02

    The American Thoracic Society and the Infectious Diseases Society of America recommend that clinically significant non-tuberculous mycobacteria (NTM) should be identified to the species level in order to determine their clinical significance. The aim of this study was to evaluate identification of rapidly growing NTM (RGM) isolated from clinical samples by using MALDI-TOF MS and a commercial molecular system. The results were compared with identification using a reference method. We included 46 clinical isolates of RGM and identified them using the commercial molecular system GenoType ® CM/AS (Hain, Lifescience, Germany), MALDI-TOF MS (Bruker) and, as reference method, partial rpoβ gene sequencing followed by BLAST and phylogenetic analysis with the 1093 sequences available in the GeneBank. The degree of agreement between GenoType ® and MALDI-TOF MS and the reference method, partial rpoβ sequencing, was 27/43 (62.8%) and 38/43 cases (88.3%) respectively. For all the samples correctly classified by GenoType ® , we obtained the same result with MALDI-TOF MS (27/27). However, MALDI-TOF MS also correctly identified 68.75% (11/16) of the samples that GenoType ® had misclassified (p=0.005). MALDI-TOF MS classified significantly better than GenoType ® . When a MALDI-TOF MS score >1.85 was achieved, MALDI-TOF MS and partial rpoβ gene sequencing were equivalent. GenoType ® was not able to distinguish between species belonging to the M. fortuitum complex. MALDI-TOF MS methodology is simple, rapid and associated with lower consumable costs than GenoType ® . The partial rpoβ sequencing methods with BLAST and phylogenetic analysis were not able to identify some RGM unequivocally. Therefore, sequencing of additional regions would be indicated in these cases. Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  8. 5. Historic American Buildings Survey Nathaniel R. Ewan, Photographer September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Nathaniel R. Ewan, Photographer September 8, 1937 INTERIOR - DETAIL OF NUMERALS (1776) ON ENCLOSED END OF ORIGINAL HOUSE - Haines-Budd House, Lumberton, Burlington County, NJ

  9. The strength of polyaxial locking interfaces of distal radius plates.

    PubMed

    Hoffmeier, Konrad L; Hofmann, Gunther O; Mückley, Thomas

    2009-10-01

    Currently available polyaxial locking plates represent the consequent enhancement of fixed-angle, first-generation locking plates. In contrast to fixed-angle locking plates which are sufficiently investigated, the strength of the new polyaxial locking options has not yet been evaluated biomechanically. This study investigates the mechanical strength of single polyaxial interfaces of different volar radius plates. Single screw-plate interfaces of the implants Palmar 2.7 (Königsee Implantate und Instrumente zur Osteosynthese GmbH, Allendorf, Germany), VariAx (Stryker Leibinger GmbH & Co. KG, Freiburg, Germany) und Viper (Integra LifeSciences Corporation, Plainsboro, NJ, USA) were tested by cantilever bending. The strength of 0 degrees, 10 degrees and 20 degrees screw locking angle was obtained during static and dynamic loading. The Palmar 2.7 interfaces showed greater ultimate strength and fatigue strength than the interfaces of the other implants. The strength of the VariAx interfaces was about 60% of Palmar 2.7 in both, static and dynamic loading. No dynamic testing was applied to the Viper plate because of its low ultimate strength. By static loading, an increase in screw locking angle caused a reduction of strength for the Palmar 2.7 and Viper locking interfaces. No influence was observed for the VariAx locking interfaces. During dynamic loading; angulation had no influence on the locking strength of Palmar 2.7. However, reduction of locking strength with increasing screw angulation was observed for VariAx. The strength of the polyaxial locking interfaces differs remarkably between the examined implants. Depending on the implant an increase of the screw locking angle causes a reduction of ultimate or fatigue strength, but not in all cases a significant impact was observed.

  10. Haine v. Leves, 7 April 1987.

    PubMed

    1987-01-01

    The Court ruled that where pupils coming from within a local community were segregated into single sex schools with differences in their curricula that resulted in a variation in educational qualification such that the school qualification of boys for tertiary education and employment was greater than that of girls, the Equal Opportunity Tribunal could conclude that the girls were being discriminated against under Section 31A of the Anti-Discrimination Act 1977. full text

  11. Status and Impacts of Arctic Freshwater Export

    NASA Astrophysics Data System (ADS)

    Haine, T. W. N.

    2017-12-01

    Large freshwater anomalies clearly exist in the Arctic Ocean. For example, liquid freshwater has accumulated in the Beaufort Gyre in the decade of the 2000s compared to 1980-2000, with an extra ≈5000 km3—about 25%—being stored. The sources of freshwater to the Arctic from precipitation and runoff have increased between these periods (most of the evidence comes from models). Despite flux increases from 2001 to 2011, it is uncertain if the marine freshwater source through Bering Strait for the 2000s has changed, as observations in the 1980s and 1990s are incomplete. The marine freshwater fluxes draining the Arctic through Fram and Davis straits are also insignificantly different. In this way, the balance of sources and sinks of freshwater to the Arctic, Canadian Arctic Archipelago (CAA), and Baffin Bay shifted to about 1200±730 km3yr-1 freshening the region, on average, during the 2000s. The observed accumulation of liquid freshwater is consistent with this increased supply and the loss of freshwater from sea ice (Figure, right). Evidence exists that such discharges can impact the Atlantic meridional overturning circulation, and hence Atlantic sector climate. Nevertheless, it appears that the observed AMOC variability since 2004, when high quality measurements began, is not attributable to anthropogenic influence. This work is based on, and updated from, Haine et al. (2015), Carmack et al. (2016), and Haine (2016). Haine, T. W. N. Ocean science: Vagaries of Atlantic overturning. Nature Geoscience, 9, 479-480, 10.1038/ngeo2748, 2016. T. W. N. Haine et al., Arctic Freshwater Export: Status, Mechanisms, and Prospects, Global Planetary Change, 125, 13-35, 10.1016/j.glopacha.2014.11.013, 2015. E. Carmack et al., Fresh water and its role in the Arctic Marine System: sources, disposition, storage, export, and physical and biogeochemical consequences in the Arctic and global oceans. J. G. Res. Biogeosciences, 10.1002/2015JG003140, 2016.

  12. 75 FR 28009 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ...). Arysta LifeScience North America, LLC. 15401 Weston Parkway, Cary, NC 27513, proposes to establish..., goat, hog, sheep, and horse fat at 0.04 ppm; cattle, goat, hog, sheep, and horse, meat byproducts...

  13. String test

    MedlinePlus

    ... Management by Laboratory Methods . 23rd ed. Philadelphia, PA: Elsevier; 2017:chap 64. Bope ET, Kellerman RD. The ... ET, ed. Conn's Current Therapy 2016 . Philadelphia, PA: Elsevier; 2016:chap 3. Haines CF, Sears CL. Infectious ...

  14. Giardia infection

    MedlinePlus

    ... eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 283. Haines CF, Sears CL. ... Gastrointestinal and Liver Disease . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 110. Nash TE, Hill DR. ...

  15. Alcoholic liver disease

    MedlinePlus

    ... FF, ed. Ferri's Clinical Advisor 2018 . Philadelphia, PA: Elsevier; 2018:59-60. Carithers RL, McClain C. Alcoholic ... Gastrointestinal and Liver Disease . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 86. Haines EJ, Oyama LC. ...

  16. 75 FR 69427 - PPL Holtwood, LLC; Notice of Application for Amendment of License and Soliciting Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... Susquehanna River, in Lancaster and York Counties, Pennsylvania. g. Filed Pursuant to: Federal Power Act, 16 U... a 33.8-acre parcel on which the Indian Steps Museum and Ulmer-Root-Haines Memorial Park and nature...

  17. Shigellosis

    MedlinePlus

    ... Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 340. DuPont HL. Approach to the ... eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 283. Haines CF, Sears CL. ...

  18. CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOS

    EPA Science Inventory

    CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOs John Haines and Shane Rogers NRMRL Science Questions MYP Science Ouestion: What BMP treatment systems and restoration technologies are most effective options for watershed management? For mixed land use wa...

  19. Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.

    PubMed

    Meaza, Abyot; Kebede, Abebaw; Yaregal, Zelalem; Dagne, Zekarias; Moga, Shewki; Yenew, Bazezew; Diriba, Getu; Molalign, Helina; Tadesse, Mengistu; Adisse, Desalegn; Getahun, Muluwork; Desta, Kassu

    2017-04-17

    Multi drug resistant tuberculosis (MDR-TB) poses formidable challenges to TB control due to its complex diagnostic and treatment challenges and often associated with a high rate of mortality. Accurate and rapid detection of MDR-TB is critical for timely initiation of treatment. Line Probe Assay (LPA) is a qualitative in vitro diagnostic test based on DNA-STRIP technology for the identification of the M. tuberculosis complex and its resistance to rifampicin (RMP) and/or isoniazid (INH). Hain Lifescience, GmbH, Germany has improved the sensitivity of Genotype MTBDRplus VER 2.0 LPA for the detection of MDR-TB; with the possibility of applying the tool in smear negative sputum samples. A cross sectional study was conducted on 274 presumptive MDR-TB patients referred to the National TB Reference Laboratory (NTRL), Ethiopian Public Health Institute (EPHI) who submitted sputum samples for laboratory diagnosis of drug resistant-TB testing. Seventy-two smear and culture positive samples processed in smear positive direct LPA category and 197 smear negative sputum samples were processed for direct LPA. Among the smear negative samples 145 (73.6%) were culture negative and 26 (13.2%) were culture positive. All specimens were processed using NALC-NaOH method and ZN smear microscopy done from sediments. Genotype MTBDRplus VER 2.0 done from processed sputum sediments and the result was compared against the reference, BACTEC MGIT 960 culture and DST. Sensitivity, specificity, PPV and NPV of Genotype MTBDRplus VER 2.0 assay was determined and P-value <0.05 was considered as statistically significant. The sensitivity, specificity, PPV and NPV of Genotype MTBDRplus VER 2.0 LPA were 96.4, 100, 100 and 96.9%, respectively for the detection of MDR-TB from direct smear positive sputum samples. The sensitivity, specificity, PPV and NPV of Genotype MTBDR plus VER 2.0 LPA were 77.8, 97.2, 82.4 and 97.2%, respectively, for the detection of M. tuberculosis from direct smear negative sputum

  20. A Situated Analysis of Global Knowledge Networks: Capital Accumulation Strategies of Transnationally Mobile Scientists in Singapore

    ERIC Educational Resources Information Center

    Sidhu, Ravinder; Yeoh, Brenda; Chang, Sushila

    2015-01-01

    This paper investigates the geographic and professional mobility of scientists employed in Singapore's publicly funded research institutes in various techno-and lifescience specialisations. Using Bourdieu's conceptual framework, we analyse the capital portfolios of individual scientists against the structures of power which have informed…

  1. Iodomethane phytotoxicity: potential role of plant nutrient uptake

    USDA-ARS?s Scientific Manuscript database

    In the spring of 2006 multi-year studies were initiated to evaluate the efficacy of Midas™ (iodomethane:chloropicrin 50:50, Arysta LifeScience Corp., Cary, NC) for production of ornamental cockscomb (Celosia argentea var. cristata) in Martin County, Florida. Treatments were untreated check, Midas™ a...

  2. Red Seaweed Enzyme-Catalyzed Bromination of Bromophenol Red: An Inquiry-Based Kinetics Laboratory Experiment for Undergraduates

    ERIC Educational Resources Information Center

    Jittam, Piyachat; Boonsiri, Patcharee; Promptmas, Chamras; Sriwattanarothai, Namkang; Archavarungson, Nattinee; Ruenwongsa, Pintip; Panijpan, Bhinyo

    2009-01-01

    Haloperoxidase enzymes are of interest for basic and applied bioscientists because of their increasing importance in pharmaceutical industry and environmental cleanups. In a guided inquiry-based laboratory experiment for life-science, agricultural science, and health science undergraduates, the bromoperoxidase from a red seaweed was used to…

  3. Bioinformatics projects supporting life-sciences learning in high schools.

    PubMed

    Marques, Isabel; Almeida, Paulo; Alves, Renato; Dias, Maria João; Godinho, Ana; Pereira-Leal, José B

    2014-01-01

    The interdisciplinary nature of bioinformatics makes it an ideal framework to develop activities enabling enquiry-based learning. We describe here the development and implementation of a pilot project to use bioinformatics-based research activities in high schools, called "Bioinformatics@school." It includes web-based research projects that students can pursue alone or under teacher supervision and a teacher training program. The project is organized so as to enable discussion of key results between students and teachers. After successful trials in two high schools, as measured by questionnaires, interviews, and assessment of knowledge acquisition, the project is expanding by the action of the teachers involved, who are helping us develop more content and are recruiting more teachers and schools.

  4. Bioinformatics Projects Supporting Life-Sciences Learning in High Schools

    PubMed Central

    Marques, Isabel; Almeida, Paulo; Alves, Renato; Dias, Maria João; Godinho, Ana; Pereira-Leal, José B.

    2014-01-01

    The interdisciplinary nature of bioinformatics makes it an ideal framework to develop activities enabling enquiry-based learning. We describe here the development and implementation of a pilot project to use bioinformatics-based research activities in high schools, called “Bioinformatics@school.” It includes web-based research projects that students can pursue alone or under teacher supervision and a teacher training program. The project is organized so as to enable discussion of key results between students and teachers. After successful trials in two high schools, as measured by questionnaires, interviews, and assessment of knowledge acquisition, the project is expanding by the action of the teachers involved, who are helping us develop more content and are recruiting more teachers and schools. PMID:24465192

  5. PoPLAR: Portal for Petascale Lifescience Applications and Research

    PubMed Central

    2013-01-01

    Background We are focusing specifically on fast data analysis and retrieval in bioinformatics that will have a direct impact on the quality of human health and the environment. The exponential growth of data generated in biology research, from small atoms to big ecosystems, necessitates an increasingly large computational component to perform analyses. Novel DNA sequencing technologies and complementary high-throughput approaches--such as proteomics, genomics, metabolomics, and meta-genomics--drive data-intensive bioinformatics. While individual research centers or universities could once provide for these applications, this is no longer the case. Today, only specialized national centers can deliver the level of computing resources required to meet the challenges posed by rapid data growth and the resulting computational demand. Consequently, we are developing massively parallel applications to analyze the growing flood of biological data and contribute to the rapid discovery of novel knowledge. Methods The efforts of previous National Science Foundation (NSF) projects provided for the generation of parallel modules for widely used bioinformatics applications on the Kraken supercomputer. We have profiled and optimized the code of some of the scientific community's most widely used desktop and small-cluster-based applications, including BLAST from the National Center for Biotechnology Information (NCBI), HMMER, and MUSCLE; scaled them to tens of thousands of cores on high-performance computing (HPC) architectures; made them robust and portable to next-generation architectures; and incorporated these parallel applications in science gateways with a web-based portal. Results This paper will discuss the various developmental stages, challenges, and solutions involved in taking bioinformatics applications from the desktop to petascale with a front-end portal for very-large-scale data analysis in the life sciences. Conclusions This research will help to bridge the gap between the rate of data generation and the speed at which scientists can study this data. The ability to rapidly analyze data at such a large scale is having a significant, direct impact on science achieved by collaborators who are currently using these tools on supercomputers. PMID:23902523

  6. 76 FR 79171 - Pesticide Products; Receipt of Applications To Register New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... disk or CD-ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot... docket ID number and other identifying information (subject heading, Federal Register date and page... Name and Address: Arysta LifeScience, North America LLC., 15401 Weston Parkway, Suite 150, Cary, NC...

  7. The Chem-Math Project: Enhancing Success in General Chemistry through the Integration of Mathematics, Problem-Solving and Conceptual Understanding. An Action-Research Study

    ERIC Educational Resources Information Center

    Kilner, William Cary

    2014-01-01

    Freshmen with declared life-science majors typically matriculate with a determination to succeed. However, inadequately-prepared students are easily overwhelmed and at risk of abandoning their aspirations for a STEM career. The investigator designed and taught weekly recitations for approximately 850 students during a five-year span, and…

  8. Investigations Into Life Science.

    ERIC Educational Resources Information Center

    Mentzer, Dean Samuel

    This laboratory manual, containing 44 exercises, is intended to be used as part of an audio-tutorial approach to laboratory work in a life-science course for student nurses. Exercises include basic techniques of miscroscopy, microbiology, electrophysiology, routine biochemical analyses of blood and urine, and microscopic examination of prepared…

  9. Recruitment Practices Change, but Issues Remain the Same

    ERIC Educational Resources Information Center

    Hugo, Esther

    2012-01-01

    What the author found most surprising about Richard Haines' survey on 1974 recruitment practices was that the major issues are still relevant. His main points about recruitment, college and counselor interaction, and the need for better information still resonate as the profession consistently calls for clarity and transparency in the college…

  10. EVALUATION OF CURRENTLY AVAILABLE ALTERNATIVES TO METHYL BROMIDE FOR ORNAMENTAL CROP PRODUCTION IN FLORIDA

    USDA-ARS?s Scientific Manuscript database

    Studies were designed to test the efficacy of the chemical alternatives, Midas™ (iodomethane:chloropicrin (pic) 50:50 [MI 50:50] and 98:2 [MI 98:2], Arysta LifeScience Corp., Cary, NC) and dimethyl disulfide:pic (Paladin™ 79:21 [DMDS], United Phosphorous, Inc., King of Prussia, PA) compared with met...

  11. 76 FR 54230 - Product Cancellation Order for Certain Pesticide Registrations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    .... 62719 Dow Agrosciences LLC, 9330 Zionsville Rd 308/2E, Indianapolis, IN 46268-1054. 66330 Arysta LifeScience North America, LLC, 15401 Weston Parkway, Suite 150, Cary, NC 27513. 86203 Mitsui Chemicals Agro.... Box 13528, Research Triangle Park, NC 27709-3528. OR060002 Bayer CropScience LP, 2 T.W. Alexander...

  12. Advancing Educational Diversity: Antifragility, Standardization, Democracy, and a Multitude of Education Options

    ERIC Educational Resources Information Center

    Fortunato, Michael W. P.

    2017-01-01

    This essay is a response to a paper by Avery and Hains that raises questions about the often unintended effects of knowledge standardization in an educational setting. While many K-12 schools are implementing common core standards, and many institutions of higher education are implementing their own standardized educational practices, the question…

  13. Distinguishing among Declarative, Descriptive and Causal Questions to Guide Field Investigations and Student Assessment

    ERIC Educational Resources Information Center

    Odom, Arthur Louis; Bell, Clare V.

    2011-01-01

    Teachers as well as students often have difficulty formulating good research questions because not all questions lend themselves to scientific investigation. The following is a guide for high-school and college life-science teachers to help students define question types central to biological field studies. The mayfly nymph was selected as the…

  14. 75 FR 13282 - Pesticide Products; Registration Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    .... Company name and address: Arysta LifeScience, North Americal LLC, 15401 Weston Parkway, Suite 150, Cary... CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709. Active...: EPA-HQ-OPP-2008-0262. Company name and address: Bayer CropScience, P.O. Box 12014, 2T.W. Alexander...

  15. 75 FR 32096 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    .... The large number of SIAPs, Takeoff Minimums and ODPs, in addition to their complex nature and the need... Rivers, MI, Three Rivers Muni Dr. Haines, NDB RWY 27, Amdt 7A, CANCELLED Brainerd, MN, Brainerd Lakes Rgnl, RNAV (GPS) RWY 5, Amdt 1 Brainerd, MN, Brainerd Lakes Rgnl, RNAV (GPS) RWY 12, Amdt 1 Brainerd...

  16. Update on Longleaf Pine Seed Supply Meeting

    Treesearch

    Mark J. Hainds

    2002-01-01

    This is an update of the activities following the September 1999 meeting concerning measures that were discussed to address the longleaf pine seed supply shortage. The people in attendance were Dr. Dean Gjerstad, Mark Haines, Robert Gandy, Larry Bishop, Dr. Ron Carey, Dr. Carey's graduate student Steve Oak, Dr. Jim Barnett, and Jill Barbour

  17. The potential impact of regional climate change on fire weather in the United States

    Treesearch

    Ying Tang; Shiyuan Zhong; Lifeng Luo; Xindi Bian; Warren E. Heilman; Julie. Winkler

    2015-01-01

    Climate change is expected to alter the frequency and severity of atmospheric conditions conducive for wildfires. In this study, we assess potential changes in fire weather conditions for the contiguous United States using the Haines Index (HI), a fire weather index that has been employed operationally to detect atmospheric conditions favorable for large and erratic...

  18. Strategies to Support Concentration

    ERIC Educational Resources Information Center

    Haines, Annette

    2017-01-01

    Annette Haines provides a comprehensive overview of concentration across the planes. She first lays the foundation for thinking about student engagement: It must be understood that concentration is found through the interest of the child, which is guided by the sensitive periods. When we understand the child's development in this way, we can offer…

  19. 75 FR 11884 - Pesticide Products; Registration Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    .... Company Name and Address: Arysta LifeScience North America, 15401 Weston Parkway, Suite 150, Cary, NC... Number: EPA-HQ-OPP-2009-0279. Company Name and Address: Bayer CropScience, P.O. Box 12014, 2 T.W...: Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709. Active...

  20. 76 FR 3138 - Notice of Receipt of Requests To Voluntarily Cancel Certain Pesticide Registrations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... Agrosciences LLC, 9330 Zionsville Rd 308/2E, Indianapolis, IN 46268- 1054. 66330 Arysta LifeScience North..., P.O. Box 18300, Greensboro, NC 27419-8300. OR-060002; WA-050007 Bayer CropScience LP, 2 T.W...: Technology Sciences Group, Inc., 1150 18th St., NW., Suite 100, Washington, DC 20036. WA-090006 Bayer Crop...

  1. Versatile fluid-mixing device for cell and tissue microgravity research applications.

    PubMed

    Wilfinger, W W; Baker, C S; Kunze, E L; Phillips, A T; Hammerstedt, R H

    1996-01-01

    Microgravity life-science research requires hardware that can be easily adapted to a variety of experimental designs and working environments. The Biomodule is a patented, computer-controlled fluid-mixing device that can accommodate these diverse requirements. A typical shuttle payload contains eight Biomodules with a total of 64 samples, a sealed containment vessel, and a NASA refrigeration-incubation module. Each Biomodule contains eight gas-permeable Silastic T tubes that are partitioned into three fluid-filled compartments. The fluids can be mixed at any user-specified time. Multiple investigators and complex experimental designs can be easily accommodated with the hardware. During flight, the Biomodules are sealed in a vessel that provides two levels of containment (liquids and gas) and a stable, investigator-controlled experimental environment that includes regulated temperature, internal pressure, humidity, and gas composition. A cell microencapsulation methodology has also been developed to streamline launch-site sample manipulation and accelerate postflight analysis through the use of fluorescent-activated cell sorting. The Biomodule flight hardware and analytical cell encapsulation methodology are ideally suited for temporal, qualitative, or quantitative life-science investigations.

  2. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria

  3. Workforce Education. Hotel and Motel Workers. A Section 353 Demonstration Project.

    ERIC Educational Resources Information Center

    Polk County Public Schools, Bartow, FL.

    This guide provides an overall view of a program designed to educate adult basic education (ABE) and English-as-a-Second-Language (ESL) students in job-related, language-oriented skills vital to their positions in the hotel/motel industry. The program was designed for the employees of Grenelefe Resort and Conference Center in Haines City, Florida,…

  4. 76 FR 70053 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... 8260-15A. The large number of SIAPs, Takeoff Minimums and ODPs, in addition to their complex nature and... Three Rivers, MI, Three Rivers Muni Dr. Haines, Takeoff Minimums and Obstacle DP, Orig Brainerd, MN, Brainerd Lakes Rgnl, ILS OR LOC/DME RWY 34, Amdt 1 Park Rapids, MN, Park Rapids Muni-Konshok Field, NDB RWY...

  5. Thirty-One Years of Group Research in "Social Psychology Quarterly" (1975-2005)

    ERIC Educational Resources Information Center

    Harrod, Wendy J.; Welch, Bridget K.; Kushkowski, Jeff

    2009-01-01

    We examined trends in group research published in Social Psychology Quarterly (SPQ) from 1975 to 2005. We identified a total of 332 papers about groups published during the time period. Following Moreland, Hogg, and Hains (1994), we created an index of interest in groups by dividing the number of pages in papers about groups by the total number of…

  6. DLA Pre-Award Contracting System

    DTIC Science & Technology

    1993-05-01

    Gulley DPSSO Bldg 33 Standards Cheryl Haines DISC-RMO Bldg 36 Lead Time Jeff Hammer DGSC-P Bldg 32 DPACS WorkloadjersonnedALT Judy Harroson DLA-Z...33 DPACS Functionality Lou JuIg DISC-RM Bldg 36 Resource Data Sandra King DLA-ZSM 3A675 Project Oversight Scotie Knott DGSC-P Bldg 33 Post Award Dave

  7. LudusScope: Accessible Interactive Smartphone Microscopy for Life-Science Education.

    PubMed

    Kim, Honesty; Gerber, Lukas Cyrill; Chiu, Daniel; Lee, Seung Ah; Cira, Nate J; Xia, Sherwin Yuyang; Riedel-Kruse, Ingmar H

    2016-01-01

    For centuries, observational microscopy has greatly facilitated biology education, but we still cannot easily and playfully interact with the microscopic world we see. We therefore developed the LudusScope, an accessible, interactive do-it-yourself smartphone microscopy platform that promotes exploratory stimulation and observation of microscopic organisms, in a design that combines the educational modalities of build, play, and inquire. The LudusScope's touchscreen and joystick allow the selection and stimulation of phototactic microorganisms such as Euglena gracilis with light. Organismal behavior is tracked and displayed in real time, enabling open and structured game play as well as scientific inquiry via quantitative experimentation. Furthermore, we used the Scratch programming language to incorporate biophysical modeling. This platform is designed as an accessible, low-cost educational kit for easy construction and expansion. User testing with both teachers and students demonstrates the educational potential of the LudusScope, and we anticipate additional synergy with the maker movement. Transforming observational microscopy into an interactive experience will make microbiology more tangible to society, and effectively support the interdisciplinary learning required by the Next Generation Science Standards.

  8. LudusScope: Accessible Interactive Smartphone Microscopy for Life-Science Education

    PubMed Central

    Kim, Honesty; Gerber, Lukas Cyrill; Chiu, Daniel; Lee, Seung Ah; Cira, Nate J.; Xia, Sherwin Yuyang; Riedel-Kruse, Ingmar H.

    2016-01-01

    For centuries, observational microscopy has greatly facilitated biology education, but we still cannot easily and playfully interact with the microscopic world we see. We therefore developed the LudusScope, an accessible, interactive do-it-yourself smartphone microscopy platform that promotes exploratory stimulation and observation of microscopic organisms, in a design that combines the educational modalities of build, play, and inquire. The LudusScope’s touchscreen and joystick allow the selection and stimulation of phototactic microorganisms such as Euglena gracilis with light. Organismal behavior is tracked and displayed in real time, enabling open and structured game play as well as scientific inquiry via quantitative experimentation. Furthermore, we used the Scratch programming language to incorporate biophysical modeling. This platform is designed as an accessible, low-cost educational kit for easy construction and expansion. User testing with both teachers and students demonstrates the educational potential of the LudusScope, and we anticipate additional synergy with the maker movement. Transforming observational microscopy into an interactive experience will make microbiology more tangible to society, and effectively support the interdisciplinary learning required by the Next Generation Science Standards. PMID:27706189

  9. Engaging Life-Sciences Students with Mathematical Models: Does Authenticity Help?

    ERIC Educational Resources Information Center

    Poladian, Leon

    2013-01-01

    Compulsory mathematics service units for the life sciences present unique challenges: even students who learn some specific skills maintain a negative attitude to mathematics and do not see the relevance of the unit towards their degree. The focus on authentic content and the presentation and teaching of global or qualitative methods before…

  10. Why Do You Write? Creative Writing and the Reflective Teacher

    ERIC Educational Resources Information Center

    Hains-Wesson, Rachael

    2013-01-01

    In this article, the author asserts that whether we write creatively or academically (or both) it takes time to understand the reasons why we "want" to write, and the more we write, the more we fully begin to appreciate why we have to write in the ?rst place. From an early age, nearly every day, Rachel Hains-Wesson actively participated in…

  11. Numerical Relativistic Quantum Optics

    DTIC Science & Technology

    2013-11-08

    Camilo, V.M. Kaspi, A.G. Lyne, R.N. Manchester, J.F. Bell, N. D’Amico, N.P.F. McKay, 24 and F. Crawford. Discovery of two high magnetic field radio... pulsars . The Astrophysical Journal, 541:367–373, Sep 2000. [15] M. Tatarakis, I. Watts, F.N. Beg, E.L. Clark, A.E. Dangor, A. Gopal, M.G. Haines, P.A

  12. Performance of the Abbott RealTime MTB RIF/INH resistance assay when used to test Mycobacterium tuberculosis specimens from Bangladesh.

    PubMed

    Kostera, Joshua; Leckie, Gregor; Abravaya, Klara; Wang, Hong

    2018-01-01

    The Abbott RealTime MTB RIF/INH Resistance Assay (RT MTB RIF/INH) is an assay for the detection of rifampicin (RIF)- and/or isoniazid (INH)-resistant Mycobacterium tuberculosis (MTB). The assay can be used to test sputum, bronchial alveolar lavage, and N-Acetyl-L-Cysteine (NALC)/NaOH pellets prepared from these samples. The assay can be used in direct testing mode, or in reflex mode following a MTB positive result produced by its companion assay, Abbott RT MTB. In this study, the direct testing mode was used to test paired sputum and NALC/NaOH pellets prepared from sputum collected from Bangladesh TB patients. One hundred and thirty two paired samples were tested. The RT MTB RIF/INH inhibition rate was 0%. One hundred and twenty-two paired samples had results above the assay limit of detection and were analyzed by comparing with results from phenotypic drug sensitivity testing, GeneXpert MTB/RIF (Xpert), and MTBDR plus (Hain). RT MTB RIF/INH results were in good agreement with those of GeneXpert and Hain. The ability of this assay to detect RIF and INH resistance may contribute to the global control of multidrug resistant tuberculosis.

  13. Sources of student engagement in Introductory Physics for Life Sciences

    NASA Astrophysics Data System (ADS)

    Geller, Benjamin D.; Turpen, Chandra; Crouch, Catherine H.

    2018-06-01

    We explore the sources of student engagement with curricular content in an Introductory Physics for Life Science (IPLS) course at Swarthmore College. Do IPLS students find some life-science contexts more interesting than others, and, if so, what are the sources of these differences? We draw on three sources of student data to answer this question: (1) quantitative survey data illustrating how interested students were in particular contexts from the curriculum, (2) qualitative survey data in which students describe the source of their interest in these particular contexts, and (3) interview data in which students reflect on the contexts that were and were not of interest to them. We find that examples that make interdisciplinary connections with students' other coursework in biology and chemistry, and examples that make connections to what students perceive to be the "real world," are particularly effective at fostering interest. More generally, students describe being deeply engaged with contexts that foster a sense of coherence or have personal meaning to them. We identify various "engagement pathways" by which different life-science students engage with IPLS content, and suggest that a curriculum needs to be flexible enough to facilitate these different pathways.

  14. ARC-2010-AC00-0168-9-Edit

    NASA Image and Video Library

    2000-11-03

    The Honorable George P. Schultz during a Visit and tour of Ames Research Center. Shown here from left to right are in the background Bill Berry, Ames Deputy Director, Dr. Tom Edwards, Chief, Aviation Systems Division, Front row, Dr. Sidney Drell, Staford University, former U S Secretary of State George Schultz, Dr Richard Haines, Senior Research Csientist, FFC at the Future Flight Central Simulator facility.

  15. Inventory of File nam.t00z.smartconus06.tm00.grib2

    Science.gov Websites

    Temperature [K] 002 surface DPT 6 hour fcst Dew Point Temperature [K] 003 surface SPFH 6 hour fcst Specific Index [K] 027 surface HINDEX 6 hour fcst Haines Index [Numeric] 028 surface TMP 5 hour fcst Temperature [K] 029 surface TMP 4 hour fcst Temperature [K] 030 surface DPT 5 hour fcst Dew Point Temperature [K

  16. Inventory of File nam.t00z.smartak06.tm00.grib2

    Science.gov Websites

    Temperature [K] 002 surface DPT 6 hour fcst Dew Point Temperature [K] 003 surface SPFH 6 hour fcst Specific Haines Index [Numeric] 029 surface TMP 5 hour fcst Temperature [K] 030 surface TMP 4 hour fcst Temperature [K] 031 surface DPT 5 hour fcst Dew Point Temperature [K] 032 surface DPT 4 hour fcst Dew Point

  17. Inventory of File nam.t00z.smartak03.tm00.grib2

    Science.gov Websites

    Temperature [K] 002 surface DPT 3 hour fcst Dew Point Temperature [K] 003 surface SPFH 3 hour fcst Specific fcst Haines Index [Numeric] 026 surface TMP 2 hour fcst Temperature [K] 027 surface TMP 1 hour fcst Temperature [K] 028 surface DPT 2 hour fcst Dew Point Temperature [K] 029 surface DPT 1 hour fcst Dew Point

  18. Inventory of File nam.t00z.smartconus12.tm00.grib2

    Science.gov Websites

    Temperature [K] 002 surface DPT 12 hour fcst Dew Point Temperature [K] 003 surface SPFH 12 hour fcst Specific hour fcst Haines Index [Numeric] 030 surface TMP 11 hour fcst Temperature [K] 031 surface TMP 10 hour fcst Temperature [K] 032 surface DPT 11 hour fcst Dew Point Temperature [K] 033 surface DPT 10 hour

  19. Appendix A: Vascular Plants of GLEES

    Treesearch

    J. D. Haines; C .M. Regan

    1994-01-01

    This appendix provides a list of 230 vascular plant taxa that were field identified and/or collected over the period 1986-1990. Field identification was done by C.L. Simmons in 1986-87 (see Chapter 2). Subsequent taxa were field identified, collected, and verified by J.D. Haines and C.M. Regan in 1988-90. Voucher specimens were verified by taxonomists at the Rocky...

  20. The Tribology of Undulated Surfaces

    DTIC Science & Technology

    1989-05-30

    wear, in effect by decreasing the impact of plowing. Lubrication, hard coatings, fiber-reinforced composites are but a few examples. All these methods ha...In addition, the effects of pad width and cavity volume fraction of the undulated surface were also investigated. A plowing model proposed for...boundary lubricated sliding is in good agreement with experimental results. It is suggested, furthermore, that the undulated surfaces provide an effective

  1. Office of Strategic Services Training during World War II

    DTIC Science & Technology

    2010-06-01

    First Central Intelligence Agency (Berkeley: University of California Press, 1972); Thomas F. Troy, Donovan and the CIA: A History of the...William E. Colby Papers, Box 14, Folder 7, Seeley G. Mudd Library, Princeton University, Princeton, New Jer- sey. 50. Gerald K. Haines, “Virginia...subject heading] 29 January 1945, 2–3, CIA Records (RG 263), Thomas Troy Files, Box 6, Folder 46, National Archives, II. In August 2008, the

  2. A Microwave Method for Measuring Moisture Content, Density, and Grain Angle of Wood.

    DTIC Science & Technology

    1985-03-01

    Livermore, CA 94550. James, William L; Yen , You - Hsin ; King, Ray J. A microwave method for measuring moisture content,density, and grain angle of wood...Note S FPL-0250 March 1985 Density, and Grain 8 Angle of Wood William L. James, Physicist Forest Products Laboratory, Madison, WI You -Hain Yen ... Yen . You -1tsin. Microwave electromagnetic nondestructive testing of wood in real- time. Madison. WI: Department of Electronic and Computer

  3. Changing from computing grid to knowledge grid in life-science grid.

    PubMed

    Talukdar, Veera; Konar, Amit; Datta, Ayan; Choudhury, Anamika Roy

    2009-09-01

    Grid computing has a great potential to become a standard cyber infrastructure for life sciences that often require high-performance computing and large data handling, which exceeds the computing capacity of a single institution. Grid computer applies the resources of many computers in a network to a single problem at the same time. It is useful to scientific problems that require a great number of computer processing cycles or access to a large amount of data.As biologists,we are constantly discovering millions of genes and genome features, which are assembled in a library and distributed on computers around the world.This means that new, innovative methods must be developed that exploit the re-sources available for extensive calculations - for example grid computing.This survey reviews the latest grid technologies from the viewpoints of computing grid, data grid and knowledge grid. Computing grid technologies have been matured enough to solve high-throughput real-world life scientific problems. Data grid technologies are strong candidates for realizing a "resourceome" for bioinformatics. Knowledge grids should be designed not only from sharing explicit knowledge on computers but also from community formulation for sharing tacit knowledge among a community. By extending the concept of grid from computing grid to knowledge grid, it is possible to make use of a grid as not only sharable computing resources, but also as time and place in which people work together, create knowledge, and share knowledge and experiences in a community.

  4. International symposium on clusters and nanomaterials (energy and life-sciences applications)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jena, Purusottam

    The International Symposium on Clusters and Nanomaterials was held in Richmond, Virginia during October 26-29, 2015. The symposium focused on the roles clusters and nanostructures play in solving outstanding problems in clean and sustainable energy and life sciences applications; two of the most important issues facing science and society. Many of the materials issues in renewable energies, environmental impacts of energy technologies as well as beneficial and toxicity issues of nanoparticles in health are intertwined. Realizing that both fundamental and applied materials issues require a multidisciplinary approach the symposium provided a forum by bringing researchers from physics, chemistry, materials science,more » and engineering fields to share their ideas and results, identify outstanding problems, and develop new collaborations. Clean and sustainable energy sessions addressed challenges in production, storage, conversion, and efficiency of renewable energies such as solar, wind, bio, thermo-electric, and hydrogen. Environmental issues dealt with air- and water-pollution and conservation, environmental remediation and hydrocarbon processing. Topics in life sciences included therapeutic and diagnostic methods as well as health hazards attributed to nanoparticles. Cross-cutting topics such as reactions, catalysis, electronic, optical, and magnetic properties were also covered. The symposium attracted 132 participants from 24 countries in the world. It featured 39 invited speakers in 14 plenary sessions, in addition to one key-note session. Eighty-five contributed papers were presented in two poster sessions and 14 papers from this list were selected to be presented orally at the end of each session to highlight hot topics. Papers presented at the symposium were reviewed and published in SPIE so that these can reach a wide audience. The symposium was highly interactive with ample time allotted for discussions and making new collaborations. The participants’ response was that this was a high quality conference and covered topics at the cutting edge of science and technology. The symposium was endorsed by the American Physical Society, The Materials Research Society, SPIE, The Metallurgical Society, and the American Vacuum Society. The symposium was supported by external grants from the National Science Foundation and the Department of Energy as well as by internal grants from Virginia Commonwealth University (Offices of the President, Provost and Vice President of Academic Affairs, Vice President of Research, Vice Provost for Life Sciences, Dean of the College of Humanities and Sciences, and the Dean of the School of Engineering). The funding from DOE was used to support partial expenses of invited speakers, students and postdoctoral fellows.« less

  5. Detection of Low-volume Blood Loss: Compensatory Reserve Versus Traditional Vital Signs

    DTIC Science & Technology

    2014-01-01

    studies have demonstrated that photoplethysmogram (PPG) wave forms obtained with a pulse oximeter sensor significantly change with volume loss.5 With this...donation, including PPG wave forms (OEM III pulse oximeter , Nonin, Minneapolis, MN), and a noninvasive BPwave form (ccNexfin, Edwards Lifesciences, Irvine...a PPG wave form obtained with a pulse oximeter sensor. CRI is calculated after 30 heart beats and is recalculated beat-to-beat in a continuous

  6. Secure Container For Discarded Hypodermic Needles

    NASA Technical Reports Server (NTRS)

    Lee, Angelene M.

    1992-01-01

    Container designed for safe retention of discarded blood-collecting hypodermic needles and similar sharp objects used in life-science experiments aboard spacecraft. Needles inserted through self-closing lid and retained magnetically. They are inserted, sharp end first, through spring-loaded flap. Long needles and needles on syringes cannot turn around in container. Can be emptied, cleaned, and reused. Used on Earth to provide unusually secure containment of sharp objects.

  7. 2002 Industry Analysis Research Paper: Global Environment, Global Industry, and Global Security: Managing the Crossroads

    DTIC Science & Technology

    2002-01-01

    from polluted wells or rivers and wastewater is discharged into ditches or untreated systems that in turn contaminate the drinking water for others who...being embedded into core business lines of many major corporations. The U.N. Conference on Environment and Development, held in Rio de Janeiro , Brazil in...climate change. Capt. Mohd Amdan Kurish, Royal Malaysian Navy Mr. John L. Gerlaugh, OSD Lt Col Thomas J. Hains, USAF. Mr. Kevin E . Holt, USMC Col

  8. Hydrodynamic Flow Control in Marine Mammals

    DTIC Science & Technology

    2008-05-06

    body- bound vorticity ( Wolfgang et al. 1999). The vorticity is smoothly propagated along the flexing body toward the tail. This vorticity is eventually...and Reichley 1985; Dolphin 1988; Pauly et al. 1998). Whales lunge toward their prey at 2.6 m/s (Jurasz and Jurasz 1979; Hain et al. 1982). The...unsteady RANS CFD code for ship hydrodynamics. IIHR Hydroscience and Engineering Report 531. Iowa City (IA): The University of Iowa. Pauly D, Trites

  9. Bioenergetic Defects and Oxidative Damage in Transgenic Mouse Models of Neurodegenerative Disorders

    DTIC Science & Technology

    2005-06-01

    Implications for Lewy body for- mation in Parkinson’s disease and dementia with Lewy bodies. 1. Folk, J. E. 1980 . Transglutaminases. Annu. Rev...Mazziotta, J. C., Pahl, J. J., St George- Hyslop , P., Neurodegen. 5:27-33. Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., and 61. Matsuishi...and isoquinoline and Bright 1980 ). Systemic administration of 3-NP inhibits derivative neurotoxicity was associated with reduced activity SDH in the

  10. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards from FY 1988 SBIR Solicitation

    DTIC Science & Technology

    1989-05-01

    FORMULATION -- FLOQUET-GALERKIN. DELPHI RESEARCH INC 701 HAINES AVE NW ALBUQUERQUE, NM 87102 CONTRACT NUMBER: PATRICK M DHOOGE TITLE: RESEARCH ON A...MEASURE THE DIELECTRIC RESPONSE OF A DIAMOND FILM AS IT GROWNS. DIESEL DYNE CORP 3044 MIDDLEBORO RD MORROW, OH 45152 CONTRACT NUMBER: RICHARD P JOHNSTON...TITLE: A STUDY OF AN ADVANCED VARIABLE CYCLE DIESEL ENGINE FOR USE IN A REMOTELY PILOTED VEHICLE TOPIC# 18 OFFICE: ASTO IDENT#: 22796 THIS STUDY IS

  11. Low Voltage Electron Beam Lithography

    DTIC Science & Technology

    1994-01-01

    September 1970 (Societe Franaise do Microscopic Elecuouique, Plaris, 1970) Vol. 2, p. 55. [31 H . C. Pfeiffer, "Basic limitations of probefonning systems...USA (editors: 0. Jobari and I. Corvin). [4) T. Groves, D. L Hunmond, H . Kuo, ’Elecmnm-beam broadening effct caused by discreteness of space charge...Electron Microscope Gun". Br. J. Appi. Phys.. February 1952, pp. 40-46. M. E. Haine, P. A. Einstein, and P. H . Brocherd. "Resistance Bias

  12. Meteorological Error Budget Using Open Source Data

    DTIC Science & Technology

    2016-09-01

    ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using Open- Source Data by J Cogan, J Smith, P...needed. Do not return it to the originator. ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using...Error Budget Using Open-Source Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) J Cogan, J Smith, P Haines

  13. A life sciences Spacelab mission simulation

    NASA Technical Reports Server (NTRS)

    Mason, J. A.; Musgrave, F. S.; Morrison, D. R.

    1977-01-01

    The paper describes the purposes of a seven-day simulated life-sciences mission conducted in a Spacelab simulator. A major objective was the evaluation of in-orbit Spacelab operations and those mission control support functions which will be required from the Payload Operations Center. Tested equipment and procedures included experiment racks, common operational research equipment, commercial off-the-shelf equipment, experiment hardware interfaces with Spacelab, experiment data handling concepts, and Spacelab trash management.

  14. The medical story. [of Skylab

    NASA Technical Reports Server (NTRS)

    Johnston, R. S.; Dietlein, L. F.; Michel, E. L.

    1975-01-01

    The paper discusses the medical program of the Skylab missions. The major medical systems discussed include the food system, the waste-management system, the personal-hygiene system, and the inflight medical support system. The life-sciences experiments conducted on Skylab are reviewed. These dealt with the cardiovascular system, mineral balance and bioassay of fluids, sleep, blood, metabolic activity, vestibular function, and time and motion studies. The medical operations were accomplished with only minor problems.

  15. Animal experimentation in Spacelab - Present and future U.S. plans

    NASA Technical Reports Server (NTRS)

    Berry, W. E.; Dant, C. C.

    1983-01-01

    Current development of life-sciences hardware and experiments for the fourth Spacelab mission in the Life Sciences Flight Experiments Program at NASA Ames is reviewed. The research-animal holding facility, the general-purpose work station, and the life sciences laboratory equipment are characterized, and the 14 Ames projects accepted for the mission are listed and discussed. Several hardware systems and experimental procedures will be verified on the Spacelab-3 mission scheduled for late 1984.

  16. Puget Sound Dredged Disposal Analysis (PSDDA). Final Environmental Impact Statement Unconfined Open-Water Disposal for Dredged Material, Phase 2. (North and South Puget Sound)

    DTIC Science & Technology

    1989-09-01

    flathead sole, rex sole, and rock sole all showed indications of blood worm infestations. One liver tumor was found in a rex sole during spring in the ZSF...concentrations Hainly in invertebrates; some trations (.01 ppb) in waters (from lOx to 42Ox reference) in fish livers ; rarely in fish of Puget Sound central...Eagle Harbor, and Sinclair fish livers , and birds in Inlet. Highest elevation industrialized ’-ban areas. along Ruston-Point Defiance Copper is a natural

  17. Bioenergetic Defects and Oxidative Damage in Transgenic Mouse Models of Neurodegenerative Disorders

    DTIC Science & Technology

    2004-05-01

    Grafton, S. T., Mazziotta, J. C., Pahl, J. J., St George- Hyslop , P., Neurodegen. 5:27-33. Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., and 61...another TCA enzyme (Porter Previous studies showed that MPTP and isoquinoline and Bright 1980 ). Systemic administration of 3-NP inhibits derivative...Brouillet E., Ferrante R., Palfi S., Dolan R., Matthews R. T. Porter D. J. T. and Bright H. J. ( 1980 ) 3-Carbanionic substrate analogues and Beal M. F

  18. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria Kaltcheva, Wojciech Kasprzak, Balamurugan Kuppusamy, James Lautenberger, George Lountos, Megan Mounts, Uma Mudunuri, Martha Sklavos, Gloriana Shelton, Alex Sorum, and Shea Wright.

  19. Immunotherapeutic Strategies in Breast Cancer:Preclinical and Clinical Trials

    DTIC Science & Technology

    2012-09-01

    in enhanced CTL responses with anti-tumor activity. Journal of Immunology. 2000;165:539-47. 24. Haining WN, Davies J, Kanzler H, Drury L, Brenn T...including pancreatic cancer that express MUCl accounted for about 72% of new cases and for 66% of the deaths [ 1]. These observations have prompted...December 12, 2002. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby

  20. A New Tool for Local Manipulation of Neuronal Micro-Circuitry with Ions and Force

    DTIC Science & Technology

    2017-02-07

    lifesci.ucsb.edu Final Report 7/30/2015-9/30/2016 3 neurons, memory , connectivity, microcircuitry 2/7/2017 Our goal is to compute the complete functional... memory trace. To date no functional connectivity map exists for living neurons at the resolution proposed here. In fact, a quantitative model of the...propagation signals are also present in cultures of human iPS-derived neurons and thus could be used to study axonal physiology in human disease models. 3

  1. Analytical and clinical performance characteristics of the Abbott RealTime MTB RIF/INH Resistance, an assay for the detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis in pulmonary specimens.

    PubMed

    Kostera, Joshua; Leckie, Gregor; Tang, Ning; Lampinen, John; Szostak, Magdalena; Abravaya, Klara; Wang, Hong

    2016-12-01

    Clinical management of drug-resistant tuberculosis patients continues to present significant challenges to global health. To tackle these challenges, the Abbott RealTime MTB RIF/INH Resistance assay was developed to accelerate the diagnosis of rifampicin and/or isoniazid resistant tuberculosis to within a day. This article summarizes the performance of the Abbott RealTime MTB RIF/INH Resistance assay; including reliability, analytical sensitivity, and clinical sensitivity/specificity as compared to Cepheid GeneXpert MTB/RIF version 1.0 and Hain MTBDRplus version 2.0. The limit of detection (LOD) of the Abbott RealTime MTB RIF/INH Resistance assay was determined to be 32 colony forming units/milliliter (cfu/mL) using the Mycobacterium tuberculosis (MTB) strain H37Rv cell line. For rifampicin resistance detection, the Abbott RealTime MTB RIF/INH Resistance assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Cepheid GeneXpert MTB/RIF. For isoniazid resistance detection, the assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Hain MTBDRplus. The performance data presented herein demonstrate that the Abbott RealTime MTB RIF/INH Resistance assay is a sensitive, robust, and reliable test for realtime simultaneous detection of first line anti-tuberculosis antibiotics rifampicin and isoniazid in patient specimens. Copyright © 2016 The Author. Published by Elsevier Ltd.. All rights reserved.

  2. Evaluation of groundwater discharge into small lakes based on the temporal distribution of radon-222

    USGS Publications Warehouse

    Dimova, N.T.; Burnett, W.C.

    2011-01-01

    In order to evaluate groundwater discharge into small lakes we constructed a model that is based on the budget of 222Rn (radon t1/2 5 3.8 d) as a tracer. The main assumptions in our model are that the lake's waters are wellmixed horizontally and vertically; the only significant 222Rn source is via groundwater discharge; and the only losses are due to decay and atmospheric evasion. In order to evaluate the groundwater-derived 222Rn flux, we monitored the 222Rn concentration in lake water over periods long enough (usually 1-3 d) to observe changes likely caused by variations in atmospheric exchange (primarily a function of wind speed and temperature). We then attempt to reproduce the observed record by accounting for decay and atmospheric losses and by estimating the total 222Rn input flux using an iterative approach. Our methodology was tested in two lakes in central Florida: one of which is thought to have significant groundwater inputs (Lake Haines) and another that is known not to have any groundwater inflows but requires daily groundwater augmentation from a deep aquifer (Round Lake). Model results were consistent with independent seepage meter data at both Lake Haines (positive seepage of ??? 1.6 ?? 104 m3 d-1 in Mar 2008) and at Round Lake (no net groundwater seepage). ?? 2011, by the American Society of Limnology and Oceanography, Inc.

  3. Sliding Charge Density Waves and Related Problems.

    DTIC Science & Technology

    1987-03-31

    mecan -field ihcorn, with r-I oI. Lcntcr,, M ith inlinite-ranve interactions, the distinction Niet the exponential divergence follow4ed hv saturation...or the incommensu- liv simuiating Eq. (2) in systems up to 377 particles in rate chain. si/c ve were -ible to restrict tinite-size eflects to the... up another qualitative difference between 0 nc twko ,cis of theoretical results: While the incommensu- 0 20 40 60 80 100 120 140 _.:e :hain. like the

  4. Novel Heterongineered Detectors for Multi-Color Infrared Sensing

    DTIC Science & Technology

    2012-01-30

    barriers”. Appl. Phys. Lett. 98, 121106 (2011) 9. A. Khoshakhlagh, F. Jaeckel C. Hains J. B. Rodriguez , L. R. Dawson, K. Malloy, and S. Krishna...AlAs etch-stop layer. The detailed processing sequence is included in the Methods. b da c n + -GaAs 200 nm Mesa lndium bump 2.1 –2.1 FPA p d SP-FPA...FPA chip. The processing scheme of the plasmonic FPA chip consists of a dry etch to form the mesa , surface passivation, ohmic metal evaporation, under

  5. Life sciences get important new data from Spacelab mission. III

    NASA Technical Reports Server (NTRS)

    Schuiling, Roelof L.; Young, Steven

    1991-01-01

    An investigation of the effects of weightlessness on the human body is reported that was conducted on a flight of the Space Shuttle Columbia. Experiments are described regarding zero-gravity effects on the human perception of balance, the growth of lymphocytes, and general life-sciences examinations of body mass, body fluid, pulmonary parameters, and echocardiograph imaging. Specific attention is given to the day-to-day operations of the mission, and particular emphasis is given to the study of rodents and jellyfish reacting to microgravity.

  6. Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel

    NASA Technical Reports Server (NTRS)

    Coder, D. W.

    1984-01-01

    Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.

  7. Microgravity: New opportunities to facilitate biotechnology development

    NASA Astrophysics Data System (ADS)

    Johnson, Terry; Todd, Paul; Stodieck, Louis S.

    1996-03-01

    New opportunities exist to use the microgravity environment to facilitate biotechnology development. BioServe Space Technologies Center for the Commercial Development of Space offers access to microgravity environments for companies who wish to perform research or develop products in three specific life-science fields: Biomedical and Pharmaceutical Research, Biotechnology and Bioprocessing Research, and Agricultural and Environmental Research. Examples of each include physiological testing of new pharmaceutical countermeasures against symptoms that are exaggerated in space flight, crystallization and testing of novel, precompetitive biopharmaceutical substances in a convection-free environment, and closed life-support system product development.

  8. Disciplinary Authenticity: Enriching the Reforms of Introductory Physics Courses for Life-Science Students

    ERIC Educational Resources Information Center

    Watkins, Jessica; Coffey, Janet E.; Redish, Edward F.; Cooke, Todd J.

    2012-01-01

    Educators and policy makers have advocated for reform of undergraduate biology education, calling for greater integration of mathematics and physics in the biology curriculum. While these calls reflect the increasingly interdisciplinary nature of biology research, crossing disciplinary boundaries in the classroom carries epistemological challenges…

  9. The Need for a Core, Interdisciplinary, Life-Sciences Curriculum in the Middle Grades.

    ERIC Educational Resources Information Center

    Heller, H. Craig

    1993-01-01

    Campaigns to improve adolescent health must involve schools, focusing on middle grades. Currently, school organization is poor, with too little good curricular material for such students. The article describes Stanford University's interdisciplinary, core, middle grades curriculum in human biology that combats alienation from science by making it…

  10. Examining Atmospheric and Ecological Drivers of Wildfires, Modeling Wildfire Occurrence in the Southwest United States, and Using Atmospheric Sounding Observations to Verify National Weather Service Spot Forecasts

    NASA Astrophysics Data System (ADS)

    Nauslar, Nicholas J.

    This dissertation is comprised of three different papers that all pertain to wildland fire applications. The first paper performs a verification analysis on mixing height, transport winds, and Haines Index from National Weather Service spot forecasts across the United States. The final two papers, which are closely related, examine atmospheric and ecological drivers of wildfire for the Southwest Area (SWA) (Arizona, New Mexico, west Texas, and Oklahoma panhandle) to better equip operational fire meteorologists and managers to make informed decisions on wildfire potential in this region. The verification analysis here utilizes NWS spot forecasts of mixing height, transport winds and Haines Index from 2009-2013 issued for a location within 50 km of an upper sounding location and valid for the day of the fire event. Mixing height was calculated from the 0000 UTC sounding via the Stull, Holzworth, and Richardson methods. Transport wind speeds were determined by averaging the wind speed through the boundary layer as determined by the three mixing height methods from the 0000 UTC sounding. Haines Index was calculated at low, mid, and high elevation based on the elevation of the sounding and spot forecast locations. Mixing height forecasts exhibited large mean absolute errors and biased towards over forecasting. Forecasts of transport wind speeds and Haines Index outperformed mixing height forecasts with smaller errors relative to their respective means. The rainfall and lightning associated with the North American Monsoon (NAM) can vary greatly intra- and inter-annually and has a large impact on wildfire activity across the SWA by igniting or suppressing wildfires. NAM onset thresholds and subsequent dates are determined for the SWA and each Predictive Service Area (PSA), which are sub-regions used by operational fire meteorologists to predict wildfire potential within the SWA, April through September from 1995-2013. Various wildfire activity thresholds using the number

  11. [Tuberculosis Laboratory Surveillance Network (TuLSA) study group. The first step for national tuberculosis laboratory surveillance: Ankara, 2011].

    PubMed

    Sezen, Figen; Albayrak, Nurhan; Özkara, Şeref; Karagöz, Alper; Alp, Alpaslan; Duyar Ağca, Filiz; İnan Süer, Asiye; Müderris, Tuba; Ceyhan, İsmail; Durmaz, Rıza; Ertek, Mustafa

    2015-04-01

    The most effective method for monitoring country-level drug resistance frequency and to implement the necessary control measures is the establishment of a laboratory-based surveillance system. The aim of this study was to summarize the follow up trend of the drug-resistant tuberculosis (TB) cases, determine the load of resistance and evaluate the capacities of laboratories depending on laboratory quality assurance system for the installation work of National Tuberculosis Laboratory Surveillance Network (TuLSA) which has started in Ankara in 2011. TuLSA studies was carried out under the coordination of National Tuberculosis Reference Laboratory (NRL) with the participation of TB laboratories and dispensaries. Specimens of TB patients, reported from health institutions, were followed in TB laboratories, and the epidemiological information was collected from the dispensaries. One isolate per patient with the drug susceptibility test (DST) results were sent to NRL from TB laboratories and in NRL the isolates were rechecked with the genotypical (MTBDRplus, Hain Lifescience, Germany) and phenotypical (MGIT 960, BD, USA) DST methods. Molecular epidemiological analysis were also performed by spoligotyping and MIRU/VNTR. Second-line DST was applied to the isolates resistant to rifampin. A total of 1276 patients were reported between January 1st to December 31th 2011, and 335 cases were defined as "pulmonary TB from Ankara province". The mean age of those patients was 43.4 ± 20 years, and 67.5% were male. Three hundred seventeen (94.6%) patients were identified as new cases. The average sample number obtained from pulmonary TB cases was 3.26 ± 2.88, and 229 (68.3%) of them was culture positive. DST was applied to all culture positive isolates; 90.4% (207/229) of cases were susceptible to the five drugs tested (ethambutol, isoniazid, pyrazinamide, rifampicin, streptomycin). Eight (3.5%) of the isolates were multidrug-resistant (MDR-TB), while no extensively drug

  12. Micro-PIV measurements of multiphase flow of water and liquid CO2 in 2-D heterogeneous porous micromodels

    NASA Astrophysics Data System (ADS)

    Li, Yaofa; Kazemifar, Farzan; Blois, Gianluca; Christensen, Kenneth T.

    2017-07-01

    We present an experimental study of pore-scale flow dynamics of liquid CO2 and water in a two-dimensional heterogeneous porous micromodel, inspired by the structure of a reservoir rock, at reservoir-relevant conditions (80 bar, 21°C). The entire process of CO2 infiltration into a water-saturated micromodel was captured using fluorescence microscopy and the micro-PIV method, which together reveal complex fluid displacement patterns and abrupt changes in velocity. The CO2 front migrated through the resident water in an intermittent manner, forming dendritic structures, termed fingers, in directions along, normal to, and even opposing the bulk pressure gradient. Such characteristics indicate the dominance of capillary fingering through the micromodel. Velocity burst events, termed Haines jumps, were also captured in the heterogeneous micromodel, during which the local Reynolds number was estimated to be ˜21 in the CO2 phase, exceeding the range of validity of Darcy's law. Furthermore, these drainage events were observed to be cooperative (i.e., across multiple pores simultaneously), with the zone of influence of such events extending beyond tens of pores, confirming, in a quantitative manner, that Haines jumps are nonlocal phenomena. After CO2 completely breaks through the porous section, shear-induced circulations caused by flowing CO2 were also observed, in agreement with previous studies using a homogeneous porous micromodel. To our knowledge, this study is the first quantitative measurement that incorporates both reservoir-relevant conditions and rock-inspired heterogeneity, and thus will be useful for pore-scale model development and validation.

  13. Parallel high-performance grid computing: capabilities and opportunities of a novel demanding service and business class allowing highest resource efficiency.

    PubMed

    Kepper, Nick; Ettig, Ramona; Dickmann, Frank; Stehr, Rene; Grosveld, Frank G; Wedemann, Gero; Knoch, Tobias A

    2010-01-01

    Especially in the life-science and the health-care sectors the huge IT requirements are imminent due to the large and complex systems to be analysed and simulated. Grid infrastructures play here a rapidly increasing role for research, diagnostics, and treatment, since they provide the necessary large-scale resources efficiently. Whereas grids were first used for huge number crunching of trivially parallelizable problems, increasingly parallel high-performance computing is required. Here, we show for the prime example of molecular dynamic simulations how the presence of large grid clusters including very fast network interconnects within grid infrastructures allows now parallel high-performance grid computing efficiently and thus combines the benefits of dedicated super-computing centres and grid infrastructures. The demands for this service class are the highest since the user group has very heterogeneous requirements: i) two to many thousands of CPUs, ii) different memory architectures, iii) huge storage capabilities, and iv) fast communication via network interconnects, are all needed in different combinations and must be considered in a highly dedicated manner to reach highest performance efficiency. Beyond, advanced and dedicated i) interaction with users, ii) the management of jobs, iii) accounting, and iv) billing, not only combines classic with parallel high-performance grid usage, but more importantly is also able to increase the efficiency of IT resource providers. Consequently, the mere "yes-we-can" becomes a huge opportunity like e.g. the life-science and health-care sectors as well as grid infrastructures by reaching higher level of resource efficiency.

  14. Rational Ruijsenaars Schneider hierarchy and bispectral difference operators

    NASA Astrophysics Data System (ADS)

    Iliev, Plamen

    2007-05-01

    We show that a monic polynomial in a discrete variable n, with coefficients depending on time variables t1,t2,…, is a τ-function for the discrete Kadomtsev-Petviashvili hierarchy if and only if the motion of its zeros is governed by a hierarchy of Ruijsenaars-Schneider systems. These τ-functions were considered in [L. Haine, P. Iliev, Commutative rings of difference operators and an adelic flag manifold, Int. Math. Res. Not. 2000 (6) (2000) 281-323], where it was proved that they parametrize rank one solutions to a difference-differential version of the bispectral problem.

  15. Applications of Artificial Intelligence in Voice Recognition Systems in Micro-Computers.

    DTIC Science & Technology

    1982-03-01

    DELTAO THEN 1290 1050 IF ANS$(I) = "HAIN MENU THEN 320 1060 IF ANS$(I) - " ABORTO THEN 3150 1070 IF ANS$(I) - 󈧄 BACK’ THEN 3590 1080 NEXT I 1090... ABORTO THEN 3150 1660 NEXT I 1670 SOTO 3350 3 REM’ ERROR PACK 1680 STOP 1690 REM SHIPS MENU 1700 REM------------ 1710 HOME : VTAB 5 :HTAB 15 :PRINT...IF ANS*(I) - PROFILESO THEN 3100 2470 IF IS$(I) - "MIN MENU" THEN 320 24Sf IF NB$(I) - "G0 BACK" THEN 3590 2490 IF ANS$(I) - " ABORTO THEN 3150 2500

  16. Screening a library of household substances for inhibitors of phosphatases: An introduction to high-throughput screening.

    PubMed

    Taylor, Ann T S

    2005-01-01

    Library screening methods are commonly used in industry and research. This article describes an experiment that screens a library of household substances for properties that would make a good "drug," including enzyme inhibition, neutral pH, and nondenaturing to proteins, using wheat germ acid phosphatase as the target protein. An adaptation of the experiment appropriate for lower level biochemistry or outreach is also described. This work was supported by Wabash College through the Haines Fund for the Study of Biochemistry and the National Science Foundation through Grant DUE 0126242. Copyright © 2005 International Union of Biochemistry and Molecular Biology, Inc.

  17. Combining turbulent kinetic energy and Haines Index predictions for fire-weather assessments

    Treesearch

    Warren E. Heilman; Xindi Bian

    2007-01-01

    The 24- to 72-hour fire-weather predictions for different regions of the United States are now readily available from the regional Fire Consortia for Advanced Modeling of Meteorology and Smoke (FCAMMS) that were established as part of the U.S. National Fire Plan. These predictions are based on daily real-time MM5 model simulations of atmospheric conditions and fire-...

  18. The Tangled Tale of Genes and Environment: Moore's The Dependent Gene: The Fallacy of “nature VS. Nurture”

    PubMed Central

    Schneider, Susan M

    2007-01-01

    Nature–nurture views that smack of genetic determinism remain prevalent. Yet, the increasing knowledge base shows ever more clearly that environmental factors and genes form a fully interactional system at all levels. Moore's book covers the major topics of discovery and dispute, including behavior genetics and the twin studies, developmental psychobiology, and developmental systems theory. Knowledge of this larger life-sciences context for behavior principles will become increasingly important as the full complexity of gene–environment relations is revealed. Behavior analysis both contributes to and gains from the larger battle for the recognition of how nature and nurture really work.

  19. Process material management in the Space Station environment

    NASA Technical Reports Server (NTRS)

    Perry, J. L.; Humphries, W. R.

    1988-01-01

    The Space Station will provide a unique facility for conducting material-processing and life-science experiments under microgravity conditions. These conditions place special requirements on the U.S. Laboratory for storing and transporting chemicals and process fluids, reclaiming water from selected experiments, treating and storing experiment wastes, and providing vacuum utilities. To meet these needs and provide a safe laboratory environment, the Process Material Management System (PMMS) is being developed. Preliminary design requirements and concepts related to the PMMS are addressed, and the MSFC PMMS breadboard test facility and a preliminary plan for validating the overall system design are discussed.

  20. Principles of complementary medicine in terms of a suggested scientific basis.

    PubMed

    Popp, Fritz-Albert

    2008-05-01

    In order to create a scientific basis of complementary medicine it is certainly necessary to add a more non-local approach to the molecular substance of orthodox "life-sciences". It should be able to explain strange phenomena like healing by homeopathy or acupuncture. A possible frame concerns oscillatory electromagnetic interactions as regulatory and - in case of disease--deregulatory impulses of the organisms. These couplings are found, for instance, in biological rhythms, external rhythmical influences (sun exposure, atmospheric disturbances), and vibrations of the body over a huge range of frequencies. One basic example is biophotons and "delayed luminescence".

  1. Radius of Curvature of the Cornea--An Experiment for the Life-Science Physics Lab

    ERIC Educational Resources Information Center

    MacLatchy, C. S.

    1978-01-01

    Presents a quantitative laboratory experiment in geometrical optics. It involves the student in the measurement of the radius of curvature of the cornea and is based on an old method devised by Kohlrausch in 1839. (Author/GA)

  2. Nanopublications for exposing experimental data in the life-sciences: a Huntington's Disease case study.

    PubMed

    Mina, Eleni; Thompson, Mark; Kaliyaperumal, Rajaram; Zhao, Jun; der Horst, van Eelke; Tatum, Zuotian; Hettne, Kristina M; Schultes, Erik A; Mons, Barend; Roos, Marco

    2015-01-01

    Data from high throughput experiments often produce far more results than can ever appear in the main text or tables of a single research article. In these cases, the majority of new associations are often archived either as supplemental information in an arbitrary format or in publisher-independent databases that can be difficult to find. These data are not only lost from scientific discourse, but are also elusive to automated search, retrieval and processing. Here, we use the nanopublication model to make scientific assertions that were concluded from a workflow analysis of Huntington's Disease data machine-readable, interoperable, and citable. We followed the nanopublication guidelines to semantically model our assertions as well as their provenance metadata and authorship. We demonstrate interoperability by linking nanopublication provenance to the Research Object model. These results indicate that nanopublications can provide an incentive for researchers to expose data that is interoperable and machine-readable for future use and preservation for which they can get credits for their effort. Nanopublications can have a leading role into hypotheses generation offering opportunities to produce large-scale data integration.

  3. Misconduct accounts for the majority of retracted scientific publications

    PubMed Central

    Fang, Ferric C.; Steen, R. Grant; Casadevall, Arturo

    2012-01-01

    A detailed review of all 2,047 biomedical and life-science research articles indexed by PubMed as retracted on May 3, 2012 revealed that only 21.3% of retractions were attributable to error. In contrast, 67.4% of retractions were attributable to misconduct, including fraud or suspected fraud (43.4%), duplicate publication (14.2%), and plagiarism (9.8%). Incomplete, uninformative or misleading retraction announcements have led to a previous underestimation of the role of fraud in the ongoing retraction epidemic. The percentage of scientific articles retracted because of fraud has increased ∼10-fold since 1975. Retractions exhibit distinctive temporal and geographic patterns that may reveal underlying causes. PMID:23027971

  4. [The recent research progress of chemistry of marine natural products].

    PubMed

    Shi, Qing-wen; Li, Li-geng; Wang, Yu-fang; Huo, Chang-hong; Zhang, Man-li

    2010-10-01

    Ocean is a unique and excellent resource that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields. This article focused on the research progress of chemistry of marine natural products in recent five years.

  5. Space applications of artificial intelligence; Proceedings of the Annual Goddard Conference, Greenbelt, MD, May 16, 17, 1989

    NASA Technical Reports Server (NTRS)

    Rash, James L. (Editor); Dent, Carolyn P. (Editor)

    1989-01-01

    Theoretical and implementation aspects of AI systems for space applications are discussed in reviews and reports. Sections are devoted to planning and scheduling, fault isolation and diagnosis, data management, modeling and simulation, and development tools and methods. Particular attention is given to a situated reasoning architecture for space repair and replace tasks, parallel plan execution with self-processing networks, the electrical diagnostics expert system for Spacelab life-sciences experiments, diagnostic tolerance for missing sensor data, the integration of perception and reasoning in fast neural modules, a connectionist model for dynamic control, and applications of fuzzy sets to the development of rule-based expert systems.

  6. Capture Cross-section Measurement of 241Am(n,γ) at J-PARC/MLF/ANNRI

    NASA Astrophysics Data System (ADS)

    Harada, H.; Ohta, M.; Kimura, A.; Furutaka, K.; Hirose, K.; Hara, K. Y.; Kin, T.; Kitatani, F.; Koizumi, M.; Nakamura, S.; Oshima, M.; Toh, Y.; Igashira, M.; Katabuchi, T.; Mizumoto, M.; Kino, K.; Kiyanagi, Y.; Fujii, T.; Fukutani, S.; Hori, J.; Takamiya, K.

    2014-05-01

    The 241Am(n, γ) 242Am cross sections have been measured for neutron energies between 0.01 and 10 eV using the Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI) installed at the Materials and Life-science experimental Facility (MLF) in J-PARC. ANNRI combines the strongest neutron-pulsed beam and a high energy resolution γ-ray spectrometer, making possible accurate measurements of neutron capture cross sections for highly radioactive samples. From the measured cross section, the Westcott neutron capture factor and strength of the first three resonances in 241Am are deduced. These results with precision less than 0.5 % are compared with those derived from JENDL-4.0.

  7. Correlation of Specific Mutations in Line Probe Assay (LPA) and Drug Susceptibility Test (DST) with respect to Fluoroquinolone Resistance in Drug Resistant Mycobacterium tuberculosis

    PubMed Central

    Agrawal, Umang; Savaj, Pratik; Davda, Kanishka; Rodrigues, Camilla; Soman, Rajeev

    2017-01-01

    Abstract Background This study was done to investigate the utility of specific fluoroquinolone mutations in LPA in predicting the susceptibility in DST at WHO recommended Critical Concentrations of 0.5 and 2 µg/dL of moxifloxacin within a short time frame as provided by LPA. Methods In a retrospective study performed at a tertiary care hospital of Mumbai, India from October 2015 to February 2017, consecutive samples demonstrating fluoroquinolone resistance by LPA were selected. The LPA kit used was Hain Lifescience Genotype MTBDRsl (Version 1). It detects the following mutations in gyrA gene: MUT1: Ala90Val, MUT2: Ser91Pro, MUT3A: Asp94Ala, MUT3B: Asp94Asn/Tyr, MUT3C: Asp94Gly, MUT3D: Asp94His. The causal mutation was noted. For 89 of these samples, DST had been requested and results with Critical Concentration of 0.5µg/dL and 2µg/dL for moxifloxacin were available Results The 89 samples studied were as follows: Sputum (n = 60), paravertebral soft tissue (n = 2), bronchoalveolar fluid (n = 2), cerebrospinal fluid (n = 1), endotracheal tube secretion (n = 1), pleural fluid (n = 1) and site not recorded (22). 3 of these samples had double mutations. Results are as follows. Mutation in gyrA gene Number of samples (n) Susceptible at 0.5 µg/dL [n (%)] Susceptible at 2 µg/dL [n (%)] MUT1 (Ala90Val) 18 6(33.33) 16(88.89) MUT2 (Ser91Pro) 2 0(0) 1(50) MUT3A (Asp94Asn) 13 3(23.07) 11(84.61) MUT3B (Asp94Asn/Tyr) 6 1(16.67) 4(66.67) MUT3C (Asp94Gly) 51 4(8) 43(84.31) MUT3D (Asp94His) 2 0(0) 2(100) Conclusion This study showed a higher proportion of M. tuberculosis susceptibility at 2 µg/dL rather than at 0.5 µg/dL, to moxifloxacin for gyrA mutations Ala90Val (MUT1), Asp94Ala (MUT3A), Asp94Gly (MUT3C), Asp94His (MUT3D) but not for Ser91Pro (MUT2) and Asp94Asn/Tyr (MUT3B). However, the number of samples with Ser91Pro (MUT2) and Asp94Asn/Tyr (MUT3B) mutations was too small for meaningful conclusion. This susceptibility at a higher critical concentration of

  8. The Development of a Personalized-System-of-Instruction Introductory Physics Course for Life-Science Students.

    ERIC Educational Resources Information Center

    McFarland, E. L.; And Others

    1978-01-01

    Describes the development and operation of a college biophysics course as well as the educational materials used, the structure of the modules and the performance of the students. Also discusses the economics of such a flexible system of instruction. (GA)

  9. Dusting off another shelf: further comments on classic gynecologic pathology books of yesteryear.

    PubMed

    Young, Robert H

    2005-01-01

    Selected outstanding books from the older literature on gynecologic pathology are reviewed with emphasis on drawing attention to the abundant helpful information and often outstanding illustrations that are worthy of review by present-day pathologists. This represents a follow up to a previous similar essay that appeared in Volume 19:67-84, 2000. The first three books cover general gynecological pathology: Gynecological Pathology by Carl Abel; Gynecological and Obstetrical Pathology by Robert T. Frank; and Haines and Taylor's Gynaecological Pathology by Magnus Haines and Claud W. Taylor. Each of them emphasizes the time-honored problem of mimicry of malignancy by diverse benign lesions or even aspects of normal histology. Awareness of the clinical background and cooperation between the clinician and pathologist are emphasized. The other three books considered are all devoted largely or exclusively to the ovary: Ovarian Tumors by Hans Selye, Ovarian Neoplasms, Morphology, and Classification by Karel Motlik, and Special Tumors of Ovary and Testis and Related Extragonadal Lesions by Gunnar Teilum. The book of Selye has a truly remarkable encyclopedic coverage of the older literature, the references being so comprehensive that they are presented in a separate volume. A number of aspects of the histopathology of ovarian tumors that have been emphasized in recent years are noted in Selye's book. Dr. Motlik's book presents a very high quality consideration of the differential diagnosis of ovarian tumors. Teilum's book contains a masterful account of the histopathology of germ cell tumors emphasizing a neoplasm with which his name will always be associated, the yolk sac tumor (endodermal sinus tumor). Numerous beautiful and refreshingly large illustrations are provided, and Dr. Teilum's interest in comparative pathology is evident in the pages, his linking of the famous Schiller-Duval bodies with the endodermal sinuses of the rat placenta, being the most notable example.

  10. Post-polio syndrome. Cases report and review of literature.

    PubMed

    Pastuszak, Żanna; Stępień, Adam; Tomczykiewicz, Kazimierz; Piusińska-Macoch, Renata; Galbarczyk, Dariusz; Rolewska, Agnieszka

    It is estimated that around 15 million people survived polio infection worldwide since early twentieth century. In 1950 effective vaccination was used for first time. Since that time number of affected people decreased. The last epidemic of Haine-Medine disease in Poland was in 1950s. Another rare cases of infections were observed till 1970s. About at least 15 years after polio virus infection, slowly progressive muscle limbs paresis with muscle atrophy, joints pain, paresthesia were observed in polio survivors. That constellation of symptoms was called post-polio syndrome (PPS). PPS frequency among people after paralytic and nonparalytic polio infectious is ranged from 30% to 80%. Fatigue that leads to physical and mental activity deterioration is another important symptom that is observed in 90% of patients with PPS. Etiology of disease remains elusive. Probably it is an effect of spine frontal horns motoneurons damage during acute virus polio infection that leads to overloading and degeneration of remaining ones. The most important risk factors of PPS are female sex and respiratory symptoms during acute polio infection. Electromyography is an important part of PPS diagnostic process. Electrophysiological abnormalities are seen in clinically affected and unaffected muscles. The most frequent are fasciculations and fibrillations during rest activity, extension of motor unit area, time duration and amplitude. In this study we described three cases of people who developed PPS years after Haine-Medine disease and correlation between their EMG results and clinical status. We also analyzed electromyography results both after one month since first PPS signs occurred as well as after few years. Presentation of dynamic changes in EMG was the most important aim of that study. Copyright © 2017. Published by Elsevier Urban & Partner Sp. z o.o.

  11. Evaluation of the Dornier Gmbh interactive grid generation system

    NASA Technical Reports Server (NTRS)

    Brown, Robert L.

    1989-01-01

    An interactive grid generation program, INGRID, is investigated and evaluated. A description of the task and work performed, a description and evaluation of INGRID, and a discussion of the possibilities for bringing INGRID into the NASA and Numerical Aerodynamic Simulator (NAS) computing environments is included. The interactive grid generation program was found to be a viable approach for grid generation and determined that it could be converted to work in the NAS environment but that INGRID does not solve the fundamentally hard problems associated with grid generation, specifically, domain decomposition.

  12. 77 FR 7005 - Airworthiness Directives; Eurocopter Deutschland GMBH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... delivered fuel flow than the engine fuel flow demand needed to achieve the OEI rating at high altitude. They...-engine-inoperative (OEI) rating at altitudes above 10,000 feet. This condition could result in high... AD would require installing a placard that corresponds to the maximum permissible flight altitude...

  13. 77 FR 32884 - Airworthiness Directives; Eurocopter Deutschland GMBH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... than the engine fuel flow demand needed to achieve the OEI rating at high altitude. They state that... above 10,000 feet. This condition could result in high altitude operations when full OEI engine power is... installing a placard that corresponds to the maximum permissible flight altitude, amending the Rotorcraft...

  14. The effects of video compression on acceptability of images for monitoring life sciences experiments

    NASA Astrophysics Data System (ADS)

    Haines, Richard F.; Chuang, Sherry L.

    1992-07-01

    Future manned space operations for Space Station Freedom will call for a variety of carefully planned multimedia digital communications, including full-frame-rate color video, to support remote operations of scientific experiments. This paper presents the results of an investigation to determine if video compression is a viable solution to transmission bandwidth constraints. It reports on the impact of different levels of compression and associated calculational parameters on image acceptability to investigators in life-sciences research at ARC. Three nonhuman life-sciences disciplines (plant, rodent, and primate biology) were selected for this study. A total of 33 subjects viewed experimental scenes in their own scientific disciplines. Ten plant scientists viewed still images of wheat stalks at various stages of growth. Each image was compressed to four different compression levels using the Joint Photographic Expert Group (JPEG) standard algorithm, and the images were presented in random order. Twelve and eleven staffmembers viewed 30-sec videotaped segments showing small rodents and a small primate, respectively. Each segment was repeated at four different compression levels in random order using an inverse cosine transform (ICT) algorithm. Each viewer made a series of subjective image-quality ratings. There was a significant difference in image ratings according to the type of scene viewed within disciplines; thus, ratings were scene dependent. Image (still and motion) acceptability does, in fact, vary according to compression level. The JPEG still-image-compression levels, even with the large range of 5:1 to 120:1 in this study, yielded equally high levels of acceptability. In contrast, the ICT algorithm for motion compression yielded a sharp decline in acceptability below 768 kb/sec. Therefore, if video compression is to be used as a solution for overcoming transmission bandwidth constraints, the effective management of the ratio and compression parameters

  15. The Bioperl Toolkit: Perl Modules for the Life Sciences

    PubMed Central

    Stajich, Jason E.; Block, David; Boulez, Kris; Brenner, Steven E.; Chervitz, Stephen A.; Dagdigian, Chris; Fuellen, Georg; Gilbert, James G.R.; Korf, Ian; Lapp, Hilmar; Lehväslaiho, Heikki; Matsalla, Chad; Mungall, Chris J.; Osborne, Brian I.; Pocock, Matthew R.; Schattner, Peter; Senger, Martin; Stein, Lincoln D.; Stupka, Elia; Wilkinson, Mark D.; Birney, Ewan

    2002-01-01

    The Bioperl project is an international open-source collaboration of biologists, bioinformaticians, and computer scientists that has evolved over the past 7 yr into the most comprehensive library of Perl modules available for managing and manipulating life-science information. Bioperl provides an easy-to-use, stable, and consistent programming interface for bioinformatics application programmers. The Bioperl modules have been successfully and repeatedly used to reduce otherwise complex tasks to only a few lines of code. The Bioperl object model has been proven to be flexible enough to support enterprise-level applications such as EnsEMBL, while maintaining an easy learning curve for novice Perl programmers. Bioperl is capable of executing analyses and processing results from programs such as BLAST, ClustalW, or the EMBOSS suite. Interoperation with modules written in Python and Java is supported through the evolving BioCORBA bridge. Bioperl provides access to data stores such as GenBank and SwissProt via a flexible series of sequence input/output modules, and to the emerging common sequence data storage format of the Open Bioinformatics Database Access project. This study describes the overall architecture of the toolkit, the problem domains that it addresses, and gives specific examples of how the toolkit can be used to solve common life-sciences problems. We conclude with a discussion of how the open-source nature of the project has contributed to the development effort. [Supplemental material is available online at www.genome.org. Bioperl is available as open-source software free of charge and is licensed under the Perl Artistic License (http://www.perl.com/pub/a/language/misc/Artistic.html). It is available for download at http://www.bioperl.org. Support inquiries should be addressed to bioperl-l@bioperl.org.] PMID:12368254

  16. The effects of video compression on acceptability of images for monitoring life sciences experiments

    NASA Technical Reports Server (NTRS)

    Haines, Richard F.; Chuang, Sherry L.

    1992-01-01

    Future manned space operations for Space Station Freedom will call for a variety of carefully planned multimedia digital communications, including full-frame-rate color video, to support remote operations of scientific experiments. This paper presents the results of an investigation to determine if video compression is a viable solution to transmission bandwidth constraints. It reports on the impact of different levels of compression and associated calculational parameters on image acceptability to investigators in life-sciences research at ARC. Three nonhuman life-sciences disciplines (plant, rodent, and primate biology) were selected for this study. A total of 33 subjects viewed experimental scenes in their own scientific disciplines. Ten plant scientists viewed still images of wheat stalks at various stages of growth. Each image was compressed to four different compression levels using the Joint Photographic Expert Group (JPEG) standard algorithm, and the images were presented in random order. Twelve and eleven staffmembers viewed 30-sec videotaped segments showing small rodents and a small primate, respectively. Each segment was repeated at four different compression levels in random order using an inverse cosine transform (ICT) algorithm. Each viewer made a series of subjective image-quality ratings. There was a significant difference in image ratings according to the type of scene viewed within disciplines; thus, ratings were scene dependent. Image (still and motion) acceptability does, in fact, vary according to compression level. The JPEG still-image-compression levels, even with the large range of 5:1 to 120:1 in this study, yielded equally high levels of acceptability. In contrast, the ICT algorithm for motion compression yielded a sharp decline in acceptability below 768 kb/sec. Therefore, if video compression is to be used as a solution for overcoming transmission bandwidth constraints, the effective management of the ratio and compression parameters

  17. Electronic Ambient-Temperature Recorder

    NASA Technical Reports Server (NTRS)

    Russell, Larry; Barrows, William

    1995-01-01

    Electronic temperature-recording unit stores data in internal memory for later readout. Records temperatures from minus 40 degrees to plus 60 degrees C at intervals ranging from 1.875 to 15 minutes. With all four data channels operating at 1.875-minute intervals, recorder stores at least 10 days' data. For only one channel at 15-minute intervals, capacity extends to up to 342 days' data. Developed for recording temperatures of instruments and life-science experiments on satellites, space shuttle, and high-altitude aircraft. Adaptable to such terrestrial uses as recording temperatures of perishable goods during transportation and of other systems or processes over long times. Can be placed directly in environment to monitor.

  18. The NASA Space Life Sciences Training Program - Preparing the way

    NASA Technical Reports Server (NTRS)

    Biro, Ronald; Munsey, Bill; Long, Irene

    1990-01-01

    Attention is given to the goals and methods adopted in the NASA Space Life Sciences Training Program (SLSTP) for preparing scientists and engineers for space-related life-sciences research and operations. The SLSTP is based on six weeks of projects and lectures which give an overview of payload processing and experiment flow in the space environment. The topics addressed in the course of the program include descriptions of space vehicles, support hardware, equipment, and research directions. Specific lecture topics include the gravity responses of plants, mission integration of a flight experiment, and the cardiovascular deconditioning. The SLSTP is shown to be an important part of the process of recruiting and training qualified scientists and engineers to support space activities.

  19. [Use of PubMed to improve evidence-based medicine in routine urological practice].

    PubMed

    Rink, M; Kluth, L A; Shariat, S F; Chun, F K; Fisch, M; Dahm, P

    2013-03-01

    Applying evidence-based medicine in daily clinical practice is the basis of patient-centered medicine and knowledge of accurate literature acquisition skills is necessary for informed clinical decision-making. PubMed is an easy accessible, free bibliographic database comprising over 21 million citations from the medical field, life-science journals and online books. The article summarizes the effective use of PubMed in routine urological clinical practice based on a common case scenario. This article explains the simple use of PubMed to obtain the best search results with the highest evidence. Accurate knowledge about the use of PubMed in routine clinical practice can improve evidence-based medicine and also patient treatment.

  20. The ELIXIR channel in F1000Research.

    PubMed

    Blomberg, Niklas; Oliveira, Arlindo; Mons, Barend; Persson, Bengt; Jonassen, Inge

    2015-01-01

    ELIXIR, the European life science infrastructure for biological information, is a unique initiative to consolidate Europe's national centres, services, and core bioinformatics resources into a single, coordinated infrastructure. ELIXIR brings together Europe's major life-science data archives and connects these with national bioinformatics infrastructures  - the ELIXIR Nodes. This editorial introduces the ELIXIR channel in F1000Research; the aim of the channel is to collect and present ELIXIR's scientific and operational output, engage with the broad life science community and encourage discussion on proposed infrastructure solutions. Submissions will be assessed by the ELIXIR channel Advisory Board to ensure they are relevant to ELIXIR community, and subjected to F1000Research open peer review process.

  1. Human performance measurement: Validation procedures applicable to advanced manned telescience systems

    NASA Technical Reports Server (NTRS)

    Haines, Richard F.

    1990-01-01

    As telescience systems become more and more complex, autonomous, and opaque to their operators it becomes increasingly difficult to determine whether the total system is performing as it should. Some of the complex and interrelated human performance measurement issues are addressed as they relate to total system validation. The assumption is made that human interaction with the automated system will be required well into the Space Station Freedom era. Candidate human performance measurement-validation techniques are discussed for selected ground-to-space-to-ground and space-to-space situations. Most of these measures may be used in conjunction with an information throughput model presented elsewhere (Haines, 1990). Teleoperations, teleanalysis, teleplanning, teledesign, and teledocumentation are considered, as are selected illustrative examples of space related telescience activities.

  2. Space Station life sciences guidelines for nonhuman experiment accommodation

    NASA Technical Reports Server (NTRS)

    Arno, R.; Hilchey, J.

    1985-01-01

    Life scientists will utilize one of four habitable modules which constitute the initial Space Station configuration. This module will be initially employed for studies related to nonhuman and human life sciences. At a later date, a new module, devoted entirely to nonhuman life sciences will be launched. This report presents a description of the characteristics of a Space Station laboratory facility from the standpoint of nonhuman research requirements. Attention is given to the science rationale for experiments which support applied medical research and basic gravitational biology, mission profiles and typical equipment and subsystem descriptions, issues associated with the accommodation of nonhuman life sciences on the Space Station, and conceptual designs for the initial operational capability configuration and later Space Station life-sciences research facilities.

  3. The ELIXIR channel in F1000Research

    PubMed Central

    Blomberg, Niklas; Oliveira, Arlindo; Mons, Barend; Persson, Bengt; Jonassen, Inge

    2016-01-01

    ELIXIR, the European life science infrastructure for biological information, is a unique initiative to consolidate Europe’s national centres, services, and core bioinformatics resources into a single, coordinated infrastructure. ELIXIR brings together Europe’s major life-science data archives and connects these with national bioinformatics infrastructures  - the ELIXIR Nodes. This editorial introduces the ELIXIR channel in F1000Research; the aim of the channel is to collect and present ELIXIR’s scientific and operational output, engage with the broad life science community and encourage discussion on proposed infrastructure solutions. Submissions will be assessed by the ELIXIR channel Advisory Board to ensure they are relevant to ELIXIR community, and subjected to F1000Research open peer review process. PMID:26913192

  4. 78 FR 22209 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... crack and prevent failure of the boom, loss of the boom and attached loads, and subsequent loss of... crack in the boom. This condition could result in loss of the boom and attached loads, and subsequent... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2013...

  5. 78 FR 78710 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... attached loads, and subsequent loss of helicopter control. DATES: This AD is effective January 31, 2014... of the boom and attached loads, and subsequent loss of helicopter control. The NPRM was prompted by... the loss of the boom and attached loads. According to EASA, boom P/Ns 44301-500 and 44307-500-1 are of...

  6. 78 FR 54383 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... the main transmission filter housing upper part and modifying the main transmission housing upper part... filter area was not manufactured in accordance with applicable design specifications. The actions of this... a corrugated washer in the filter housing of the housing upper part and modifying each affected main...

  7. 78 FR 16196 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... corrugated washer in the middle of the main transmission filter housing upper part and modifying the main... revealed the bypass inlet in the oil filter area was not manufactured in accordance with applicable design... revealed the bypass inlet in the oil filter area had not been manufactured in accordance with the...

  8. 78 FR 40053 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... filter element for a chip. If the analysis indicates Stage III as defined by the ASB, this proposed AD would require removing and inspecting the oil filter element for a chip within 10 hours TIS. If there are no chips, we propose cleaning the oil filter element and chip detector, inspecting the drive stage...

  9. 78 FR 42677 - Airworthiness Directives; Austro Engine GmbH Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... making a regulatory distinction, and (4) Will not have a significant economic impact, positive or..., Aviation safety, Incorporation by reference, Safety. Adoption of the Amendment Accordingly, under the...

  10. 78 FR 48599 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...-reference service information, the economic evaluation, any comments received, and other information. The...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... justifies making a regulatory distinction; and (4) Will not have a significant economic impact, positive or...

  11. 76 FR 76330 - Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Directorate, 901 Locust, Kansas City, Missouri 64106. For information on the availability of this material at... proposed AD. Discussion The European Aviation Safety Agency (EASA), which is the Technical Agent for the... 13 September 2011, for the English language version and in issue 2, dated 22 October 2008, for the...

  12. 77 FR 52265 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... total area of corrosion or thread damage, or both, covers less than 25 percent of the length of the... paragraph (d)(3) of this AD. (B) If the total area of corrosion or thread damage, or both, covers 25 percent... to require inspections for corrosion or thread damage to each tail rotor balance weight (weight) and...

  13. 78 FR 70209 - Airworthiness Directives; XtremeAir GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ...: Final rule; request for comments. SUMMARY: We are adopting a new airworthiness directive (AD) for Xtreme... lower left landing gear attachment bearing and the lower engine mount to the firewall attachment plate... Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590. Hand Delivery: U.S. Department of...

  14. Legionnaires disease presenting as acute kidney injury in the absence of pneumonia.

    PubMed

    Yogarajah, Meera; Sivasambu, Bhradeev

    2015-02-17

    Legionnaires disease is a pneumonic illness with multisystem involvement. In 1987, Haines et al reported the only reported case of isolated renal disease of legionellosis without concurrent respiratory disease. A 62-year-old man presented with generalised weakness and malaise and watery diarrhoea, and was found to have acute kidney injury on admission. He was initially managed as acute gastroenteritis complicated with dehydration and acute kidney injury with intravenous hydration. Despite adequate hydration, his renal function was worsening day by day. Later in the course of his sickness he developed pneumonic illness and was diagnosed with Legionnaires disease after a positive urine antigen test. We are reporting the second case of Legionnaires disease presenting as an isolated acute kidney injury in the absence of respiratory symptoms on presentation. 2015 BMJ Publishing Group Ltd.

  15. The Space Station Freedom - International cooperation and innovation in space safety

    NASA Technical Reports Server (NTRS)

    Rodney, George A.

    1989-01-01

    The Space Station Freedom (SSF) being developed by the United States, European Space Agency (ESA), Japan, and Canada poses novel safety challenges in design, operations, logistics, and program management. A brief overview discloses many features that make SSF a radical departure from earlier low earth orbit (LEO) space stations relative to safety management: size and power levels; multiphase manned assembly; 30-year planned lifetime, with embedded 'hooks and scars' forevolution; crew size and skill-mix variability; sustained logistical dependence; use of man, robotics and telepresence for on-orbit maintenance of station and free-flyer systems; closed-environment recycling; use of automation and expert systems; long-term operation of collocated life-sciences and materials-science experiments, requiring control and segregation of hazardous and chemically incompatible materials; and materials aging in space.

  16. Coherent total internal reflection dark-field microscopy: label-free imaging beyond the diffraction limit.

    PubMed

    von Olshausen, Philipp; Rohrbach, Alexander

    2013-10-15

    Coherent imaging is barely applicable in life-science microscopy due to multiple interference artifacts. Here, we show how these interferences can be used to improve image resolution and contrast. We present a dark-field microscopy technique with evanescent illumination via total internal reflection that delivers high-contrast images of coherently scattering samples. By incoherent averaging of multiple coherent images illuminated from different directions we can resolve image structures that remain unresolved by conventional (incoherent) fluorescence microscopy. We provide images of 190 nm beads revealing resolution beyond the diffraction limit and slightly increased object distances. An analytical model is introduced that accounts for the observed effects and which is confirmed by numerical simulations. Our approach may be a route to fast, label-free, super-resolution imaging in live-cell microscopy.

  17. [Anesthetic Management Using Transesophageal Echocardiography and EV1000 in a Patient with Ebstein's Anomary Undergoing Scoliosis Surgery].

    PubMed

    Tanimura, Kazuki; Miura, Yukiko; Ishii, Hisanari

    2016-02-01

    An 18-year-old female patinet with Ebstein anomaly underwent surgical repair of scoliosis under total intravenous anesthesia. In addtition to normal monitors, we used transesophageal echocardiography (TEE) and EV1000 (Edwards Lifesciences, Irvine, USA), which show stroke volume variation and stroke volume index simultaneously in a rectangular coordinates. TEE detected reversal of intracardiac shunt which caused SpO2 decrease during fixing screws at thoracic vertebrae, then manual ventilation with oxygen unproved SpO2. Because of a high venous pressure due to Ebstein anomaly, surgical bleeding seemed to be larger than usual. By using EV1000, volume status and cardiac contractility were estimated and adequate volume loading and inoptrope injection were performed to stabilize circulatory condition. The operation was completed without any cardiac and respiratory complications.

  18. 78 FR 19431 - Safety Zones; Annual Independence Day Fireworks Displays, Skagway, Haines, and Wrangell, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... combination of a large number of spectators, congested waterways, darkness punctuated by bright flashes of... be of short duration, approximately three hours. Furthermore, vessels may be authorized to transit...

  19. 78 FR 38200 - Safety Zones; Annual Independence Day Fireworks Displays, Skagway, Haines, and Wrangell, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ..., darkness punctuated by bright flashes of light, and burning debris has the potential to result in serious... enforcement of these safety zones will be of short duration, approximately three hours. Furthermore, vessels...

  20. Tyrosinase Inhibitory Activities of Carissa opaca Stapf ex Haines Roots Extracts and Their Phytochemical Analysis

    PubMed Central

    Malik, Wajeeha; Ahmed, Dildar; Izhar, Sania

    2017-01-01

    Objective: Carissa opaca is a medicinal plant with rich folkloric applications. The present research was conducted to explore the tyrosinase inhibitory potential of aqueous decoction (AD) and methanolic extract (ME) of roots of C. opaca and its fractions in various solvents and their phytochemical analysis. Materials and Methods: AD of the dried powdered roots of C. opaca was prepared by boiling in water. ME was prepared by cold maceration. Its fractions were obtained in solvents of increasing polarity, i.e., hexane, chloroform, ethyl acetate, n-butanol, and water. The biomass left after extraction with methanol was boiled in water to get its decoction Biomass aqueous decoction (BAD). Tyrosinase inhibitory activities of the samples were studied according to a reported method. Chemical compounds in the samples were identified by gas chromatography-mass spectrometry (GC-MS). Results: The AD, BAD, and ME and its fractions displayed remarkable tyrosinase inhibitory activity. The IC50 of AD was 23.33 μg/mL as compared to 15.80 μg/mL of the standard arbutin and that of BAD was 21.24 μg/mL. The IC50 of ME was 34.76 μg/mL while that of hexane, chloroform, ethyl acetate, n-butanolic, and aqueous fractions was 21.0, 44.73, 43.40, 27.66, and 25.06 μg/mL, respectively. The hexane fraction was thus most potent followed by aqueous fraction. By phytochemical analysis, campesterol, stigmasterol, gamma-sitosterol, alpha-amyrin, 9,19-cyclolanostan-3-ol, 24-methylene-,(3 β)-, lupeol, lup-20(29)-en-3-one, lup-20(29)-en-3-ol, acetate,(3 β)-, 2(1H) naphthalenone, 3,5,6,7,8,8a-hexahydro-4,8a-dimethyl-6-(1-methylethenyl)-, and 2,3,3-trimethyl-2-(3-methylbuta-1,3-dienyl)-6-methylenecyclohexanone were identified in the extracts by GC-MS. Other compounds included fatty acids and their esters. Some of these compounds are being first time reported here from this plant. Conclusions: The roots extracts exhibited considerable tyrosinase inhibitory activities, alluding to a possible application of the plant in cosmetic as whitening agent subject to further pharmacological studies. SUMMARY The present study aimed to explore the tyrosinase inhibitory potential of aqueous decoction and methanolic extract of roots of Carissa opaca and its fractions in various solvents and their phytochemical constituents. GCMS analysis was conducted to identify the phytochemicals. The extracts and fractions of C. opaca roots showed remarkable anti-tyrosinase activities alluding to their possible application to treat disorders related to overproduction of melanin. Abbreviations used: AD: Aqueous decoction; ME: Methanolic extract; BAD: Biomass aqueous decoction; GC-MS: Gas chromatography-mass spectrometry. PMID:29142412

  1. Moving beyond Traditional Measures of Entrepreneurial Intentions in a Study among Life-Sciences Students in the Netherlands

    ERIC Educational Resources Information Center

    Lans, Thomas; Gulikers, Judith; Batterink, Maarten

    2010-01-01

    The rationale behind this study is that entrepreneurship education programmes (EEP) in post-compulsory education mainly address entrepreneurial intentions, instead of actual entrepreneurial behaviour, and that students, compared to practicing entrepreneurs, might have a wide range of entrepreneurial intentions when entering such a programme. The…

  2. 78 FR 23696 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... longitudinal main rotor actuator piston after shut-down of the external pump drive, during rigging of the main... rotor controls, of movement of the longitudinal main rotor actuator piston after shut-down of the external pump drive. Such movement could cause incorrect rigging results. The proposed actions are intended...

  3. 77 FR 66409 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... of an unsuitable self-locking nut on the bell crank of the elevator push rod that can cause failure... in the tail section of the fuselage, as a result of installation of a non-suitable self-locking nut... identified that its current configuration has a failure potential when components such as thin self-securing...

  4. 78 FR 14160 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... aviation product. The MCAI describes the unsafe condition as installation of an unsuitable self-locking nut... fuselage, as a result of installation of a non-suitable self-locking nut. The subsequent design review of... configuration has a failure potential when components such as thin self-securing nuts and bearings are aging and...

  5. 77 FR 1624 - Airworthiness Directives; Schempp-Hirth Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... must be done by a properly certificated aircraft mechanic. (2) Before further flight after doing the... inspection by a properly certificated aircraft mechanic. (h) Other FAA AD Provisions The following provisions...

  6. 78 FR 66666 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... available in the AD docket shortly after receipt. FOR FURTHER INFORMATION CONTACT: Mike Kiesov, Aerospace... Invited We invite you to send any written relevant data, views, or arguments about this proposed AD. Send... trigger by using the G1000 ampere-meter signals. The trigger is set once an alternator provides less than...

  7. 78 FR 45471 - Airworthiness Directives; Schempp-Hirth Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    .... The MCAI describes the unsafe condition as the instructions provided to inspect the propeller hub and...: It was found that the accomplishment instructions provided to check the powered sailplane's propeller... propeller hub and blades are insufficient for detecting cracks and/or other damage, and other operating...

  8. 78 FR 16604 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... unsafe condition as the engine air inlet filter is subject to icing. We are issuing this AD to require... warmer air conditions. The subsequent investigation identified that the engine air inlet filter is... with a manually controlled alternate air valve which bypasses the inlet air filter and provides...

  9. 76 FR 65421 - Airworthiness Directives; Schempp-Hirth Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... the unsafe condition as: It has been reported that small cracks on engine pylons, in the area of the lower engine support, were not detected through the ``standard'' inspection required by the daily... not detected and corrected, could lead to an engine pylon failure and consequent damage to the...

  10. 78 FR 77567 - Airworthiness Directives; Schempp-Hirth Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... availability of this material at the FAA, call (816) 329-4148. FOR FURTHER INFORMATION CONTACT: Jim Rutherford...: Discussion We issued a notice of proposed rulemaking (NPRM) to amend 14 CFR part 39 to include an AD that...=FAA-2013-0661-0002. (i) Material Incorporated by Reference (1) The Director of the Federal Register...

  11. Bioprosthetic Aortic Valve Durability: A Meta-Regression of Published Studies.

    PubMed

    Wang, Mansen; Furnary, Anthony P; Li, Hsin-Fang; Grunkemeier, Gary L

    2017-09-01

    To compare structural valve deterioration (SVD) among bioprosthetic aortic valve types, a PubMed search found 54 papers containing SVD-free curves extending to at least 10 years. The curves were digitized and fit to Weibull distributions, and the mean times to valve failure (MTTF) were calculated. Twelve valve models were collapsed into four valve types: Medtronic (Medtronic, Minneapolis, MN) and Edwards (Edwards Lifesciences, Irvine, CA) porcine; and Sorin (Sorin Group [now LivaNova], London, United Kingdom) and Edwards pericardial. Meta-regression found MTTF was associated with the patient's age, publication year, SVD definition, and valve type. Sorin pericardial valves had significantly lower risk-adjusted MTTF (higher SVD risk), and there were no significant differences in MTTF among the other three valve types. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  12. Effects of Near-Surface Atmospheric Stability and Moisture on Wildfire Behavior and Consequences for Haines Index

    Treesearch

    Ruiyu Sun; Mary Ann Jenkins

    2003-01-01

    Since the 1950s, extensive research has been conducted to investigate the relationship between near-surface atmospheric conditions and large wildfire growth and occurrence. Observational studies have demonstrated that near-surface dryness (e-g., Fahnestock 1965) and atmospheric instability (e-g., Brotak and Reifsnyder 1977) are correlated with large wildfire growth and...

  13. Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kitagawa, A.; Drentje, A. G.; Fujita, T.

    With about 1000-h of relativistic high-energy ion beams provided by Heavy Ion Medical Accelerator in Chiba, about 70 users are performing various biology experiments every year. A rich variety of ion species from hydrogen to xenon ions with a dose rate of several Gy/min is available. Carbon, iron, silicon, helium, neon, argon, hydrogen, and oxygen ions were utilized between 2012 and 2014. Presently, three electron cyclotron resonance ion sources (ECRISs) and one Penning ion source are available. Especially, the two frequency heating techniques have improved the performance of an 18 GHz ECRIS. The results have satisfied most requirements for life-sciencemore » studies. In addition, this improved performance has realized a feasible solution for similar biology experiments with a hospital-specified accelerator complex.« less

  14. Comparison of the socio-demographic and clinical features of pulmonary TB patients infected with sub-lineages within the W-Beijing and non-Beijing Mycobacterium tuberculosis.

    PubMed

    Hu, Yi; Mathema, Barun; Zhao, Qi; Zheng, Xubin; Li, Dange; Jiang, Weili; Wang, Weibing; Xu, Biao

    2016-03-01

    Highly lethal outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are increasing. Mycobacterium tuberculosis variant Beijing family and its members is regarded as a successful clone of M. tuberculosis that is associated with drug resistance in China. Understanding the genetic characteristics and molecular mechanism of drug resistant tuberculosis within Beijing family may help to clarify its origin and evolutionary history and the driving forces behind its emergence and current dissemination. Totally of 1222 Mycobacterium tuberculosis isolates were recovered from patients in six counties of two provinces in eastern China within 2010/2012. Strain lineage and its major subgroups were studied respectively by using Spoligotyping and MIRU-VNTR. The 1st-line drug susceptibility was analyzed by proportional method and 2nd-line drug susceptibility was determined by the HAINs MTBDRsl test. The genetic characterization of drug resistance was analyzed by sequencing the previously reported genes and loci associated with drug resistance together with the multiple genotyping including MIRU-VNTR, Spoligotyping and LSP genotyping. Of the 1222 Mtb isolates, 298 (24.4%) were resistant to 1st-line drug and 73 (5.9%) were simultaneously resistant to INH and RIF namely MDR-TB. Respectively 23.8% of 1st-line drug resistant TB and 12.0% of the drug susceptible TB contained the mutation associated with 2nd-line drugs by HAINs test. The Spoligotyping of 1222 Mtb isolates revealed the 967 (79.1%) of the isolates belonged to the W-Beijing family. Within W-Beijing family, 78.8% MDR-TB were observed in the isolates with simultaneous deletion of RD105 and RD207, with sub-lineage 181 accounting for 75% of MDR-TB. Analysis of 24 MIRU-VNTR loci revealed that 88.2% (15/17) of MDR and extensively drug resistant (XDR) clustered isolates were sub-lineage 181. Sublineage 181 might have the capacity to spread throughout the general community in rural China. This is

  15. Inclusive jet cross sections in proton-proton collisions at 7.0 TeV center-of-mass energy with the ATLAS detector at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    Park-Martinez, Jayne Irene

    The purpose of this study was to assess the effects of node-link mapping on students' meaningful learning and conceptual change in a 1-semester introductory life-science course. This study used node-link mapping to integrate and apply the National Research Council's (NRC, 2005) three principles of human learning: engaging students' prior knowledge, fostering their metacognition, and supporting their formulation of a scientific conceptual framework. The study was a quasi-experimental, pretest-posttest, control group design. The sample consisted of 68 primarily freshmen non-science majors enrolled in two intact sections of the targeted course. Both groups received the same teacher-centered instruction and student-centered activities designed to promote meaningful learning and conceptual change; however, the activity format differed. Control group activities were written; treatment group activities were node-link mapped. Prior to instruction, both groups demonstrated equivalent knowledge and misconceptions associated with genetics and evolution (GE), and ecology and environmental science (EE). Mean differences, pre-to-post instruction, on the GE and EE meaningful learning exam scores and the EE conceptual change inventory scores between the writing group (control) and the node-link mapping group (treatment) were analyzed using repeated measures MANOVAs. There were no significant mean pre-to-post differences between groups with respect to meaningful learning in the GE or EE units, or conceptual change in the EE unit. However, independent of group membership, the overall mean pre-to-post increases in meaningful learning and conceptual change were significant. These findings suggest that both node-link mapping and writing, when used in conjunction with the National Research Council's (NRC, 2005) three principles of human learning, can promote meaningful learning and conceptual change. The only significant interaction found with respect to meaningful learning, conceptual

  16. [Rationalities of knowledge production: on transformations of objects, technologies and information in biomedicine and the life sciences].

    PubMed

    Paul, Norbert W

    2009-09-01

    Since decades, scientific change has been interpreted in the light of paradigm shifts and scientific revolutions. The Kuhnian interpretation of scientific change however is now more and more confronted with non-disciplinary thinking in both, science and studies on science. This paper explores how research in biomedicine and the life sciences can be characterized by different rationalities, sometimes converging, sometimes contradictory, all present at the same time with varying ways of influence, impact, and visibility. In general, the rationality of objects is generated by fitting new objects and findings into a new experimental context. The rationality of hypotheses is a move towards the construction of novel explanatory tools and models. This is often inseparable meshing with the third, the technological rationality, in which a technology-driven, self-supporting and sometimes self-referential refinement of methods and technologies comes along with an extension into other fields. During the second and the third phase, the new and emerging fields tend to expand their explanatory reach not only across disciplinary boundaries but also into the social sphere, creating what has been characterized as "exceptionalism" (e.g. genetic exceptionalism or neuro-exceptionalism). Finally, recent biomedicine and life-sciences reach a level in which experimental work becomes more and more data-driven because the technologically constructed experimental systems generate a plethora of findings (data) which at some point start to blur the original hypotheses. For the rationality of information the materiality of research practices becomes secondary and research objects are more and more getting out of sight. Finally, the credibility of science as a practice becomes more and more dependent on consensus about the applicability and relevance of its results. The rationality of interest (and accountability) has become more and more characteristic for a research process which is no longer

  17. Law, evolution and the brain: applications and open questions.

    PubMed Central

    Jones, Owen D

    2004-01-01

    This paper discusses several issues at the intersection of law and brain science. It focuses principally on ways in which an improved understanding of how evolutionary processes affect brain function and human behaviour may improve law's ability to regulate behaviour. It explores sample uses of such 'evolutionary analysis in law' and also raises questions about how that analysis might be improved in the future. Among the discussed uses are: (i) clarifying cost-benefit analyses; (ii) providing theoretical foundation and potential predictive power; (iii) assessing comparative effectiveness of legal strategies; and (iv) revealing deep patterns in legal architecture. Throughout, the paper emphasizes the extent to which effective law requires: (i) building effective behavioural models; (ii) integrating life-science perspectives with social-science perspectives; (iii) considering the effects of brain biology on behaviours that law seeks to regulate; and (iv) examining the effects of evolutionary processes on brain design. PMID:15590611

  18. Law, evolution and the brain: applications and open questions.

    PubMed

    Jones, Owen D

    2004-11-29

    This paper discusses several issues at the intersection of law and brain science. It focuses principally on ways in which an improved understanding of how evolutionary processes affect brain function and human behaviour may improve law's ability to regulate behaviour. It explores sample uses of such 'evolutionary analysis in law' and also raises questions about how that analysis might be improved in the future. Among the discussed uses are: (i) clarifying cost-benefit analyses; (ii) providing theoretical foundation and potential predictive power; (iii) assessing comparative effectiveness of legal strategies; and (iv) revealing deep patterns in legal architecture. Throughout, the paper emphasizes the extent to which effective law requires: (i) building effective behavioural models; (ii) integrating life-science perspectives with social-science perspectives; (iii) considering the effects of brain biology on behaviours that law seeks to regulate; and (iv) examining the effects of evolutionary processes on brain design.

  19. New robotic telescopes by Halfmann-Teleskoptechnik GmbH and Tuparev Technologies Inc.

    NASA Astrophysics Data System (ADS)

    Bischoff, Karsten; Hessman, Frederic V.; Tuparev, Georg; Atanasova, Ekatarina; Pessev, Peter

    2008-07-01

    We will present aspects of the installation, commissioning, software development, and early operation of several new robotic telescopes: 1) the 1.2-m MONET/South telescope at Sutherland/ZA, the second Halfmann telescope for the MONET telescope network (the other telescope has been in operation at McDonald Observatory in Texas since early 2006); 2) a siderostat for a 0.5-m vacuum tower telescope for the new physics building of the Georg-August-Universitat Göttingen and 3) new developments for smaller (down to 0.5m) aperture telescopes. Special emphasis will be given to drive technology: using torque motors we adjust maximum slewing speeds of 10°/sec as standard. Although sufficient for most projects we are investigating even faster slewing speeds.

  20. 78 FR 53630 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... rod for conformity following Alexander Schleicher Automatischer H[ouml]henruderanschlu[beta] (English... Manual (CAM) 18, Maintenance, Repair, And Alteration, Of Airframes, Powerplants, Propellers, And...--and-- Guidance--Library/rgccab.nsf/0/41df1277f2dc7e0e86257bcf005112bf/ $FILE/CAM--18--1959.pdf...

  1. 78 FR 47228 - Airworthiness Directives; Thielert Aircraft Engines GmbH Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... allows the crankcase assembly opening to be susceptible to contamination from external sources. This... contamination of the engine clutch by coolant spillage during the last maintenance operation. The contamination.... The design of the engine allows the crankcase assembly opening to be susceptible to contamination from...

  2. Pyroconvection Risk in Australia: Climatological Changes in Atmospheric Stability and Surface Fire Weather Conditions

    NASA Astrophysics Data System (ADS)

    Dowdy, Andrew J.; Pepler, Acacia

    2018-02-01

    Extreme wildfires with strong convective processes in their plumes have recently led to disastrous impacts on various regions of the world. The Continuous Haines index (CH) is used in Australia to represent vertical atmospheric stability and humidity measures relating to pyroconvective processes. CH climatology is examined here using reanalysis data from 1979 to 2016, revealing large spatial and seasonal variations throughout Australia. Various measures of severity are investigated, including regionally specific thresholds. CH is combined with near-surface fire weather conditions, as a type of compound event, and is examined in relation to environmental conditions associated with pyroconvection. Significant long-term changes in CH are found for some regions and seasons, with these changes corresponding to changes in near-surface conditions in some cases. In particular, an increased risk of pyroconvection is identified for southeast Australia during spring and summer, due to decreased vertical atmospheric stability and humidity combined with more severe near-surface conditions.

  3. Studies of aerothermal loads generated in regions of shock/shock interaction in hypersonic flow

    NASA Technical Reports Server (NTRS)

    Holden, Michael S.; Moselle, John R.; Lee, Jinho

    1991-01-01

    Experimental studies were conducted to examine the aerothermal characteristics of shock/shock/boundary layer interaction regions generated by single and multiple incident shocks. The presented experimental studies were conducted over a Mach number range from 6 to 19 for a range of Reynolds numbers to obtain both laminar and turbulent interaction regions. Detailed heat transfer and pressure measurements were made for a range of interaction types and incident shock strengths over a transverse cylinder, with emphasis on the 3 and 4 type interaction regions. The measurements were compared with the simple Edney, Keyes, and Hains models for a range of interaction configurations and freestream conditions. The complex flowfields and aerothermal loads generated by multiple-shock impingement, while not generating as large peak loads, provide important test cases for code prediction. The detailed heat transfer and pressure measurements proved a good basis for evaluating the accuracy of simple prediction methods and detailed numerical solutions for laminar and transitional regions or shock/shock interactions.

  4. Advancing educational diversity: antifragility, standardization, democracy, and a multitude of education options

    NASA Astrophysics Data System (ADS)

    Fortunato, Michael W. P.

    2017-03-01

    This essay is a response to a paper by Avery and Hains that raises questions about the often unintended effects of knowledge standardization in an educational setting. While many K-12 schools are implementing common core standards, and many institutions of higher education are implementing their own standardized educational practices, the question is raised about what is lost in this effort to ensure regularity and consistency in educational outcomes. One such casualty may be local knowledge, which in a rural context includes ancestral knowledge about land, society, and cultural meaning. This essay explores whether or not efforts to standardize crowd out such knowledge, and decrease the diversity of knowledge within our society's complex ecosystem—thus making the ecosystem weaker. Using antifragility as a useful idea for examining system complexity, the essay considers the impact of standardization on innovation, democracy, and the valuation of some forms of knowledge (and its bearers) above others.

  5. Quantitation without Calibration: Response Profile as an Indicator of Target Amount.

    PubMed

    Debnath, Mrittika; Farace, Jessica M; Johnson, Kristopher D; Nesterova, Irina V

    2018-06-21

    Quantitative assessment of biomarkers is essential in numerous contexts from decision-making in clinical situations to food quality monitoring to interpretation of life-science research findings. However, appropriate quantitation techniques are not as widely addressed as detection methods. One of the major challenges in biomarker's quantitation is the need to have a calibration for correlating a measured signal to a target amount. The step complicates the methodologies and makes them less sustainable. In this work we address the issue via a new strategy: relying on position of response profile rather than on an absolute signal value for assessment of a target's amount. In order to enable the capability we develop a target-probe binding mechanism based on a negative cooperativity effect. A proof-of-concept example demonstrates that the model is suitable for quantitative analysis of nucleic acids over a wide concentration range. The general principles of the platform will be applicable toward a variety of biomarkers such as nucleic acids, proteins, peptides, and others.

  6. Organic synthesis toward small-molecule probes and drugs

    PubMed Central

    Schreiber, Stuart L.

    2011-01-01

    “Organic synthesis” is a compound-creating activity often focused on biologically active small molecules. This special issue of PNAS explores innovations and trends in the field that are enabling the synthesis of new types of small-molecule probes and drugs. This perspective article frames the research described in the special issue but also explores how these modern capabilities can both foster a new and more extensive view of basic research in the academy and promote the linkage of life-science research to the discovery of novel types of small-molecule therapeutics [Schreiber SL (2009) Chem Bio Chem 10:26–29]. This new view of basic research aims to bridge the chasm between basic scientific discoveries in life sciences and new drugs that treat the root cause of human disease—recently referred to as the “valley of death” for drug discovery. This perspective article describes new roles that modern organic chemistry will need to play in overcoming this challenge. PMID:21464328

  7. The Chemo-Biological Outreach of Nano-Biomaterials: Implications for Tissue Engineering and Regenerative Medicine.

    PubMed

    Kumar, Pradeep; Choonara, Yahya E; Khan, Riaz A; Pillay, Viness

    2017-01-01

    Nanobiomaterials can be defined as materials interacting with and influencing the biological microenvironment at a nanointerface. Recently the basic as well as applied research related to nanobiomaterials - a conjugation of nano-, material- and life-sciences - has immensely evolved for therapeutics and related biotechnology areas. The current overview focused on the potential of nanobiomaterial-based substrates towards the generation of biocompatible surfaces, tissue engineering architectures, and regenerative medicine. Emphasis was given to chemomolecular functionalization of nanobiomaterials, nanobiomaterial composites, and morphomechanically modified nanoarchetypes and their inherent chemo-biological interaction with the biological microenvironment. Additionally, recent developments in nanobiomaterial substrate design and structure, chemo-biological interface related bio-systems uses and further evolving applications in health care, therapeutics and nanomedicine were discussed herein. Furthermore, a special emphasis was placed on the nano-chemo-biological interactions inherent to various nanobiomaterial substrates in close vicinity with biological systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  8. Characterization of Wet Air Plasma Jet Powered by Sinusoidal High Voltage and Nanosecond Pulses for Plasma Agricultural Application

    NASA Astrophysics Data System (ADS)

    Takashima, Keisuke; Shimada, Keisuke; Konishi, Hideaki; Kaneko, Toshiro

    2015-09-01

    Not only for the plasma sterilization but also for many of plasma life-science applications, atmospheric pressure plasma devices that allowed us to control its state and reactive species production are deserved to resolve the roles of the chemical species. Influence of the hydroxyl radical and ozone on germination of conidia of a strawberry pathogen is presented. Water addition to air plasma jet significantly improves germination suppression performance, while measured reactive oxygen species (ROS) are reduced. Although the results show a negative correlation between ROS and the germination suppression, this infers the importance of chemical composition generated by plasma. For further control of the plasma product, a plasma jet powered by sinusoidal high voltage and nanosecond pulses is developed and characterized with the voltage-charge Lissajous. Control of breakdown phase and discharge power by pulse-imposed phase is presented. This work is supported by JSPS KAKENHI Grant-in-Aid for Young Scientists (B) Grant Number 15K17480 and Exploratory Research Grant Number 23644199.

  9. Transcatheter aortic valve implantation transapical: step by step.

    PubMed

    Walther, Thomas; Möllmann, Helge; van Linden, Arnaud; Kempfert, Jörg

    2011-01-01

    Transcatheter aortic valve implantation (T-AVI) has been introduced into clinical practice to treat high-risk elderly patients with aortic stenosis. T-AVI can be performed by using a retrograde transfemoral (TF), transsubclavian, transaortic, and/or antegrade transapical (TA) approach. For TA-AVI, CE mark approval was granted in 2008 for the Edwards SAPIEN (Edwards Lifesciences, Irvine, CA) prosthesis with the Ascendra delivery system and in 2010 for the second-generation Edwards SAPIEN XT prosthesis and the Ascendra II delivery system, with 23-mm and 26-mm valves. In 2011, CE mark approval has been granted for TA-AVI by using the SAPIEN XT 29-mm prosthesis. Several other devices from different companies (Jenavalve, Jena Valve Inc, Munich, Germany; Embracer, Medtronic Inc, Guilford, CT; Accurate, Symetis Inc, Geneva, Switzerland) have passed "first in man trials" successfully and are being evaluated within multicenter pivotal studies. In this article we will focus on specific aspects of the TA technique for AVI. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Towards seasonal Arctic shipping route predictions

    NASA Astrophysics Data System (ADS)

    Haines, K.; Melia, N.; Hawkins, E.; Day, J. J.

    2017-12-01

    should become a key component of the future Arctic observing system. Melia, N., K. Haines, and E. Hawkins (2016), Sea ice decline and 21st century trans-Arctic shipping routes, Geophys. Res. Lett., doi:10.1002/ 2016GL069315. Melia, N., K. Haines, E. Hawkins and J.J. Day, 2017, Towards seasonal Arctic shipping route predictions. Env. Res. Lett., doi:10.1088/1748-9326/aa7a60

  11. 77 FR 64437 - Airworthiness Directives; Burkhart GROB Luft-und Raumfahrt GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... can remove with metal wool and that has no visible pitting in the base metal. If you cannot remove the corrosion with metal wool or if there is visible pitting in the base metal, we define it as heavy corrosion. (3) If any cracks or heavy corrosion are found during any of the inspections required in paragraph (f...

  12. 78 FR 1726 - Airworthiness Directives; Burkhart GROB Luft- und Raumfahrt GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... purposes of this AD, we define slight corrosion as corrosion you can remove with metal wool and that has no visible pitting in the base metal. If you cannot remove the corrosion with metal wool or if there is visible pitting in the base metal, we define it as heavy corrosion. (3) If any cracks or heavy corrosion...

  13. 76 FR 72128 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... Service Information We reviewed TAE Service Bulletin (SB) No. TM TAE 125-1007 P1, Revision 3, dated...-E002801. Use paragraphs A. through B. of TAE Service Bulletin (SB) No. TM TAE 125-1007 P1, Revision 3, dated October 17, 2011, or SB No. TM TAE 125-1007 P1, Revision 2, dated April 29, 2009, to do the...

  14. Tourism and its effects on southeast Alaska communities and resources: case studies from Haines, Craig, and Hoonah, Alaska.

    Treesearch

    Lee K. Cerveny

    2005-01-01

    Tourism has become integral to southeast Alaska’s regional economy and has resulted in changes to the social and cultural fabric of community life as well as to natural resources used by Alaskans. This study incorporates an ethnographic approach to trace tourism development in three rural southeast Alaska communities featuring different levels and types of tourism. In...

  15. 75 FR 53661 - Ball Bearings and Parts Thereof From France, Germany, Italy, Japan, and the United Kingdom: Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... successor-in-interest to the pre-acquisition myonic GmbH. Finally, we are announcing our revocation of the..., 2009. We invited interested parties to comment on the Preliminary Results. We received case and... determined that myonic GmbH is the successor-in-interest to the pre-acquisition myonic GmbH and invited...

  16. Pore-scale modeling of phase change in porous media

    NASA Astrophysics Data System (ADS)

    Juanes, Ruben; Cueto-Felgueroso, Luis; Fu, Xiaojing

    2017-11-01

    One of the main open challenges in pore-scale modeling is the direct simulation of flows involving multicomponent mixtures with complex phase behavior. Reservoir fluid mixtures are often described through cubic equations of state, which makes diffuse interface, or phase field theories, particularly appealing as a modeling framework. What is still unclear is whether equation-of-state-driven diffuse-interface models can adequately describe processes where surface tension and wetting phenomena play an important role. Here we present a diffuse interface model of single-component, two-phase flow (a van der Waals fluid) in a porous medium under different wetting conditions. We propose a simplified Darcy-Korteweg model that is appropriate to describe flow in a Hele-Shaw cell or a micromodel, with a gap-averaged velocity. We study the ability of the diffuse-interface model to capture capillary pressure and the dynamics of vaporization/condensation fronts, and show that the model reproduces pressure fluctuations that emerge from abrupt interface displacements (Haines jumps) and from the break-up of wetting films.

  17. Biscrolling nanotube sheets and functional guests into yarns

    NASA Astrophysics Data System (ADS)

    Baughman, Ray

    2011-03-01

    Multifunctional applications of textiles have been limited by the inability to spin important materials into yarns. Generically applicable methods are demonstrated for producing weavable yarns comprising up to 95 wt % of otherwise unspinnable particulate or nanofiber powders that remain highly functional. Scrolled 50 nm thick carbon nanotube sheets confine these powders in the galleries of irregular scroll sacks, whose observed complex structures are related to twist-dependent extension of Archimedean spirals, Fermat spirals, or spiral pairs into scrolls. The strength and electronic connectivity of a small weight fraction of scrolled carbon nanotube sheet enables yarn weaving, sewing, knotting, braiding, and charge collection. This technology is used to make yarns of superconductors, Li-ion battery materials, graphene ribbons, catalytic nanofibers for fuel cells, and Ti O2 for photocatalysis. Work done in collaboration with Shaoli Fang, Xavier Lepro-Chavez, Chihye Lewis, Raquel Ovalle-Robles, Javier Carratero-Gonzalez, Elisabet Castillo-Martinez, Mikhail Kozlov, Jiyoung Oh, Neema Rawat, Carter Haines, Mohammed Haque, Vaishnavi Aare, Stephanie Stoughton, Anvar Zakhidov, and Ray Baughman, The University of Texas at Dallas / Alan G. MacDiarmid NanoTech Institute.

  18. Integrating bio-prosthetic valves in the Fontan operation - Novel treatment to control retrograde flow in caval veins

    NASA Astrophysics Data System (ADS)

    Vukicevic, Marija; Conover, Timothy; Zhou, Jian; Hsia, Tain-Yen; Figliola, Richard

    2012-11-01

    For a child born with only one functional heart ventricle, the sequence of palliative surgeries typically culminates in the Fontan operation. This procedure is usually successful initially, but leads to later complications, for reasons not fully understood. Examples are respiratory-dependent retrograde flows in the caval and hepatic veins, and increased pulmonary vascular resistance (PVR), hypothesized to be responsible for elevated pressure in the liver and disease of the liver and intestines. Here we study the parameters responsible for retrograde flows in the inferior vena cava (IVC) and hepatic vein (HV), and investigate two novel interventions to control retrograde flow: implanting either a Medtronic Contegra valved conduit or an Edwards lifescience pericardial aortic valve in the IVC or HV. We performed the experiments in a multi-scale, patient specific mock circuit, with normal and elevated PVR, towards the optimization of the Fontan circulation. The results show that both valves can significantly reduce retrograde flows in the veins, suggesting potential advantages in the treatment of the patients with congenital heart diseases. Fondation Leducq

  19. NEXUS/Physics: An interdisciplinary repurposing of physics for biologists

    NASA Astrophysics Data System (ADS)

    Redish, E. F.; Bauer, C.; Carleton, K. L.; Cooke, T. J.; Cooper, M.; Crouch, C. H.; Dreyfus, B. W.; Geller, B. D.; Giannini, J.; Gouvea, J. S.; Klymkowsky, M. W.; Losert, W.; Moore, K.; Presson, J.; Sawtelle, V.; Thompson, K. V.; Turpen, C.; Zia, R. K. P.

    2014-05-01

    In response to increasing calls for the reform of the undergraduate science curriculum for life science majors and pre-medical students (Bio2010, Scientific Foundations for Future Physicians, Vision & Change), an interdisciplinary team has created NEXUS/Physics: a repurposing of an introductory physics curriculum for the life sciences. The curriculum interacts strongly and supportively with introductory biology and chemistry courses taken by life-science students, with the goal of helping students build general, multi-discipline scientific competencies. NEXUS/Physics stresses interdisciplinary examples and the content differs markedly from traditional introductory physics to facilitate this: it extends the discussion of energy to include interatomic potentials and chemical reactions, the discussion of thermodynamics to include enthalpy and Gibbs free energy and includes a serious discussion of random vs coherent motion including diffusion. The development of instructional materials is coordinated with careful education research. Both the new content and the results of the research are described in a series of papers for which this paper serves as an overview and context.

  20. NASA and the search for life in the universe.

    PubMed

    Dick, Steven J

    2006-06-01

    Almost from its beginnings in 1958, the National Aeronautics and Space Administration (NASA) set up a life-science program. Because one of the priorities of the organization is to search for life beyond Earth, NASA began designing spacecraft to unravel the mysteries of Mars. The effort to search for life on Mars culminated in the landing of two Viking spacecraft on the surface of the planet in 1976. Although the biology experiments conducted as part of these missions provided some evidence for the possibility of life, the scientific consensus was that they drew a blank. In 1996, however, the 'Mars rock' rekindled interest in life in our solar system. The discovery of an ocean on the Jovian moon Europa, of organic molecules on the Saturnian moon Titan and persuasive evidence that water once flowed on Mars suggests that the solar system is still of considerable exobiological interest. In addition, since 1995 approximately 175 planets have been found beyond our solar system. Although these discoveries are gas giants, NASA spacecraft might soon detect Earth-sized planets. The search for life in the universe continues.

  1. DNA Physical Mapping via the Controlled Translocation of Single Molecules through a 5-10nm Silicon Nitride Nanopore

    NASA Astrophysics Data System (ADS)

    Stein, Derek; Reisner, Walter; Jiang, Zhijun; Hagerty, Nick; Wood, Charles; Chan, Jason

    2009-03-01

    The ability to map the binding position of sequence-specific markers, including transcription-factors, protein-nucleic acids (PNAs) or deactivated restriction enzymes, along a single DNA molecule in a nanofluidic device would be of key importance for the life-sciences. Such markers could give an indication of the active genes at particular stage in a cell's transcriptional cycle, pinpoint the location of mutations or even provide a DNA barcode that could aid in genomics applications. We have developed a setup consisting of a 5-10 nm nanopore in a 20nm thick silicon nitride film coupled to an optical tweezer setup. The translocation of DNA across the nanopore can be detected via blockades in the electrical current through the pore. By anchoring one end of the translocating DNA to an optically trapped microsphere, we hope to stretch out the molecule in the nanopore and control the translocation speed, enabling us to slowly scan across the genome and detect changes in the baseline current due to the presence of bound markers.

  2. TAVR Through Heavily Calcified Aorta Following Atheroma Retrieval With the "Elevator" Technique.

    PubMed

    Senguttuvan, N Boopathy; Ellozy, Sharif; Tejani, Furqan; Kovacic, Jason; Kini, Annapoorna S; Sharma, Samin K; Dangas, George D

    2015-10-01

    An 86-year-old Caucasian female with severe symptomatic, inoperable aortic stenosis was accepted for high-risk transfemoral transcatheter aortic valve replacement (TAVR) approach due to severe calcification of the aorta. During initial passage of a 22 Fr sheath, there was dislodgment with proximal migration of a circumferential tunnel of calcium from the infrarenal aorta. A novel "elevator" technique was used to secure and retrieve the dislodged aorta en bloc back to its original infrarenal aortic position and allow in situ fixation with stenting. A new TAVR system was then successfully placed through the stent and a 23 mm Edwards Sapien valve (Edwards Lifesciences) was implanted as planned. In case of calcification protruding into the lumen of the aorta and limiting the passage of the large valve delivery system sheath, the obstruction can be managed by stenting the calcification against the luminal wall under fluoroscopic and intravascular-ultrasound guidance, allowing successful passage of the valve delivery system. The elevator technique allows axial transportation of any calcified vascular fragments, should they become dislodged.

  3. A moral economy of American medicine in the managed-care era.

    PubMed

    Sprinkle, R H

    2001-06-01

    The moral economy of American medicine has been transformed by contentious innovations in organization, administration, regulation, and finance. In many settings old fee-for-service incentives and disincentives have been replaced by those of "managed care", while in other settings they have been diluted or distorted. In the everyday care of patients, old and new may alternate or interact. These innovations may also be having secondary effects on participation in life-sciences research and the development and employment of new technologies, discouraging collective support for preliminary investigation and delaying adoption of improved goods and services until cost-reducing potential has already been realized. This motivational complexity, particularly in its moral dimensions, is hard to address using standard assumptions and methods. I argue for different assumptions, based on the clinical behavior of individual patients rather than the market behavior of aggregated consumers, and I describe a different method, based on an old idea in political economy. I then present a new way to explain the core obligations of clinicians, researchers, and planners and to interpret the policy problems they must now share.

  4. Biotic games and cloud experimentation as novel media for biophysics education

    NASA Astrophysics Data System (ADS)

    Riedel-Kruse, Ingmar; Blikstein, Paulo

    2014-03-01

    First-hand, open-ended experimentation is key for effective formal and informal biophysics education. We developed, tested and assessed multiple new platforms that enable students and children to directly interact with and learn about microscopic biophysical processes: (1) Biotic games that enable local and online play using galvano- and photo-tactic stimulation of micro-swimmers, illustrating concepts such as biased random walks, Low Reynolds number hydrodynamics, and Brownian motion; (2) an undergraduate course where students learn optics, electronics, micro-fluidics, real time image analysis, and instrument control by building biotic games; and (3) a graduate class on the biophysics of multi-cellular systems that contains a cloud experimentation lab enabling students to execute open-ended chemotaxis experiments on slimemolds online, analyze their data, and build biophysical models. Our work aims to generate the equivalent excitement and educational impact for biophysics as robotics and video games have had for mechatronics and computer science, respectively. We also discuss how scaled-up cloud experimentation systems can support MOOCs with true lab components and life-science research in general.

  5. Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis.

    PubMed

    Drobniewski, Francis; Cooke, Mary; Jordan, Jake; Casali, Nicola; Mugwagwa, Tendai; Broda, Agnieszka; Townsend, Catherine; Sivaramakrishnan, Anand; Green, Nathan; Jit, Mark; Lipman, Marc; Lord, Joanne; White, Peter J; Abubakar, Ibrahim

    2015-05-01

    introducing rapid molecular testing (in addition to culture and drug sensitivity testing). Probabilistic sensitivity analysis was performed to evaluate the impact on cost-effectiveness of diagnostic and treatment time delays, diagnosis and treatment costs, and associated QALYs. A total of 8922 titles and abstracts were identified, with 557 papers being potentially eligible. Of these, 56 studies contained sufficient test information for analysis. All three commercial tests performed well when detecting drug resistance in clinical samples, although with evidence of heterogeneity between studies. Pooled sensitivity for GenoType® MTBDRplus (Hain Lifescience, Nehren, Germany) (isoniazid and rifampicin resistance), INNO-LiPA Rif.TB® (Fujirebio Europe, Ghent, Belgium) (rifampicin resistance) and Xpert® MTB/RIF (Cepheid Inc., Sunnyvale, CA, USA) (rifampicin resistance) was 83.4%, 94.6%, 95.4% and 96.8%, respectively; equivalent pooled specificity was 99.6%, 98.2%, 99.7% and 98.4%, respectively. Results of the transmission model suggest that all of the rapid assays considered here, if added to the current diagnostic pathway, would be cost-saving and achieve a reduction in expected QALY loss compared with current practice. GenoType MTBDRplus appeared to be the most cost-effective of the rapid tests in the South Asian population, although results were similar for GeneXpert. In all other scenarios GeneXpert appeared to be the most cost-effective strategy. Rapid molecular tests for rifampicin and isoniazid resistance were sensitive and specific. They may also be cost-effective when added to culture drug susceptibility testing in the UK. There is global interest in point-of-care testing and further work is needed to review the performance of emerging tests and the wider health-economic impact of decentralised testing in clinics and primary care, as well as non-health-care settings, such as shelters and prisons. This study is registered as PROSPERO CRD42011001537. The National Institute

  6. 77 FR 75189 - Certain Light-Emitting Diodes and Products Containing Same; Commission Determination Not To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... Corporate Center USA, Hella, Inc., Automotive Lighting Reutlingen GmbH, Automotive Lighting LLC, Tecnologia..., Inc., Automotive Lighting Reutlingen GmbH, Automotive Lighting, LLC, and [[Page 75190

  7. 77 FR 51462 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... landing and damage to the airplane. DATES: This AD becomes effective September 10, 2012. We must receive... carburetor, which could result in an in-flight engine shutdown, forced landing and damage to the airplane. (e... pump with an S/N listed in Table 1 to paragraph (c) of this AD in any airplane unless it has been...

  8. Ingrid Rinner-Kuhn v. FWW. Spezial-Gebaudereinigung GmbH. and Co. [13 July 1989].

    PubMed

    1989-01-01

    The plaintiff worked 10 hours a week for the defendant and, when she became ill, sought payment of her wages under the German sick pay law. After her employer refused to pay her, citing a provision of the German law that exempted employers from paying for sickness leave when a worker works fewer than 10 hours a week, she challenged the law as violating equal pay provisions of Article 119 of the European Communities Treaty. To support her challenge she pointed to statistics showing that a far greater percentage of workers working no more than 10 hours a week were women than men. Upon referral of the case by the German court hearing it, the European Court of Justice held that Article 119 precludes national legislation permitting employers to exclude from payment of sick pay employees who do not work more than 10 hours a week if that measure affects a far greater number of men than women, unless it is shown that the legislation is justified by objective facts unrelated to any discrimination based on sex. It also ruled that it was up to the German court to determine whether the legislation in question was so justified.

  9. 77 FR 12450 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... have been tightened to the correct torque value, i.e. not in accordance with the specification. This... AD requires performing a one-time inspection of the oil system for leaks and a torque check of the... performing a one-time inspection of the oil system for leaks and a torque check of the oil pump attachment...

  10. 78 FR 22166 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... contact with FAA personnel concerning this AD. Using the search function of the Web site, anyone can find...) Carbon is a visual buildup of dark carbon deposits on the center and grounding electrodes as well as the...

  11. 76 FR 63167 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes With Supplemental Type...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... airplane weight and balance. We are issuing this AD to correct the unsafe condition on these products... revise hour = $255. weight and balance. According to the manufacturer, all of the costs of this AD may be... weight and balance. (h) Optional Actions If all actions in paragraphs (g)(1), (g)(2), (g)(3), and (g)(4...

  12. Toward the Standardization of Bioreactors for Space Research

    NASA Astrophysics Data System (ADS)

    Garcia, Michel; Nebuloni, Stefano; Dainesi, Paolo; Gass, Samuel

    Growing interest in long-term human space missions and exploration as well as future plans for extra-terrestrial human settlements, places increasing importance on understanding biological and chemical processes in space at cellular and molecular level. RUAG Space has been involved in the development of bioreactors for life-science experiments in space for the past 20 years. Throughout these developments, RUAG has acted as the link between scientists and the space industry, translating high-level scientific requirements into technical requirements, verifying their feasibility within the space context, and developing state-of-the-art experiment hardware which can interface with dedicated micro-gravity platform. Although this approach has brought forth promising developments in the field, it is associated to very long development phases as well as correspondingly high costs. Each new scientific experiment is often associated to an entirely new hardware development. This is, in large, due to the limited information available on the possibilities and constraints imposed by the particular context of space. Therefore, a considerable amount of time and development costs are invested in order to accommodate stringent scientific requirements and/or specific experiment design in space hardware. This does not only have an impact on funding opportunities for micro-gravity experiments in space, it also curbs the pace of scientific discoveries and limits the number of research opportunities. Therefore, in the following, we present an overview of already established possibilities for cellular research in space, with special emphasis on hardware developed by RUAG Space. This is intended to provide scientists with key technical information on already existing bioreactors, subsystems, and components, which may be used as a basis when designing scientific studies. By considering this information from the onset of the establishment of scientific requirements, technical solutions can

  13. 75 FR 28294 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-PXI Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... Instruments GmbH, Landshut-Altdorf, GERMANY; Keithly Instruments, Solon, OH; Elektrobit Austria GmbH, Vienna, AUSTRIA; DiagnoSYS Systems Ltd., Hampshire, UNITED KINGDOM; and Elma Electronic Inc., Fremont, CA, have...

  14. 78 FR 76624 - Notice of Agreements Filed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... Marine, Ltd. Filing Party: Wade S. Hooker, Esq.; 211 Central Park W; New York, NY 10024. Synopsis: The... HLC Agreement. Parties: BBC Chartering & Logistics GmbH & Co. KG; Beluga Chartering GmbH; Chipolbrok...

  15. 76 FR 58768 - Ball Bearings and Parts Thereof From France, Germany, and Italy; Amended Final Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... determined for this company continues to be 5.47 percent. Germany: ``BSH Bosch and Siemens Hausgerate GmbH'' has been changed to ``BSH Bosch und Siemens Hausgerate GmbH;'' ``Volkswagon AG'' has been changed to...

  16. GOCE User Toolbox and Tutorial

    NASA Astrophysics Data System (ADS)

    Knudsen, P.; Benveniste, J.

    2011-07-01

    The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products. GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made available as well. GUT has been developed in a collaboration within the GUT Core Group. The GUT Core Group: S. Dinardo, D. Serpe, B.M. Lucas, R. Floberghagen, A. Horvath (ESA), O. Andersen, M. Herceg (DTU), M.-H. Rio, S. Mulet, G. Larnicol (CLS), J. Johannessen, L.Bertino (NERSC), H. Snaith, P. Challenor (NOC), K. Haines, D. Bretherton (NCEO), C. Hughes (POL), R.J. Bingham (NU), G. Balmino, S. Niemeijer, I. Price, L. Cornejo (S&T), M. Diament, I Panet (IPGP), C.C. Tscherning (KU), D. Stammer, F. Siegismund (UH), T. Gruber (TUM),

  17. New Insights on co-seismic landslide clustering

    NASA Astrophysics Data System (ADS)

    Meunier, Patrick; Marc, Odin; Hovius, Niels

    2015-04-01

    Earthquake-triggered landslides tend to cluster along topographic crests while rainfall-induced landslides should occur downslope preferentially, where pore pressure induced by groundwater flows is the highest [1]. Past studies on landslide clustering are all based on the analysis of complete dataset or subdataset of landslides associated with a given event (seismic or climatic) as a whole. In this work, we document the spatial and temporal variations of the landslide position (on hillslopes) within the epicentral area of the 1994 Northridge, the 1999 Chichi, the 2004 Niigata, the 2008 Iwate and the 2008 Wenchuan earthquakes. We show that crest clustering is not systematic, non uniform in space and exhibit patterns that vary a lot from one case to another. These patterns are not easy to interpret as they don't seem to be controlled by a single governing parameter but result from a complex interaction between local (hillslope length and gradient, lithology) and seismic (distance to source, slope aspect, radiation pattern, coseismic uplift) parameters. [1] Meunier, P., Hovius, N., & Haines, J. A. (2008). Topographic site effects and the location of earthquake induced landslides. Earth and Planetary Science Letters, 275(3), 221-232

  18. Into the complexity of coseismic landslide clustering

    NASA Astrophysics Data System (ADS)

    Meunier, Patrick; Marc, Odin; Uchida, Taro; Hovius, Niels

    2014-05-01

    Earthquake-triggered landslides tend to cluster along topographic crests while rainfall-induced landslides are more uniformly distributed on hillslopes [1]. In theory, rainfall induced landslides should even occur downslope preferentially, where pore pressure induced by groundwater flows is the highest. Past studies on landslide clustering are all based on the analysis of complete dataset or subdataset of landslides associated with a given event (seismic or climatic) as a whole. In this work, we document the spatial variation of the landslide position (on hillslopes) within the epicentral area for the cases of the 1999 Chichi, the 2004 Niigata and the 2008 Iwate earthquakes. We show that landslide clustering is not uniform in space and exhibit patterns that vary a lot from one case to another. These patterns are not easy to interpret as they don't seem to be controlled by a single governing parameter but result from a complex interaction between local (hillslope length and gradient, lithology) and seismic (distance to source, slope aspect, radiation pattern, coseismic uplift) parameters. [1] Meunier, P., Hovius, N., & Haines, J. A. (2008). Topographic site effects and the location of earthquake induced landslides. Earth and Planetary Science Letters, 275(3), 221-232.

  19. Temperature Data Assimilation with Salinity Corrections: Validation for the NSIPP Ocean Data Assimilation System in the Tropical Pacific Ocean, 1993-1998

    NASA Technical Reports Server (NTRS)

    Troccoli, Alberto; Rienecker, Michele M.; Keppenne, Christian L.; Johnson, Gregory C.

    2003-01-01

    The NASA Seasonal-to-Interannual Prediction Project (NSIPP) has developed an Ocean data assimilation system to initialize the quasi-isopycnal ocean model used in our experimental coupled-model forecast system. Initial tests of the system have focused on the assimilation of temperature profiles in an optimal interpolation framework. It is now recognized that correction of temperature only often introduces spurious water masses. The resulting density distribution can be statically unstable and also have a detrimental impact on the velocity distribution. Several simple schemes have been developed to try to correct these deficiencies. Here the salinity field is corrected by using a scheme which assumes that the temperature-salinity relationship of the model background is preserved during the assimilation. The scheme was first introduced for a zlevel model by Troccoli and Haines (1999). A large set of subsurface observations of salinity and temperature is used to cross-validate two data assimilation experiments run for the 6-year period 1993-1998. In these two experiments only subsurface temperature observations are used, but in one case the salinity field is also updated whenever temperature observations are available.

  20. Heat flux viscosity in collisional magnetized plasmas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, C., E-mail: cliu@pppl.gov; Fox, W.; Bhattacharjee, A.

    2015-05-15

    Momentum transport in collisional magnetized plasmas due to gradients in the heat flux, a “heat flux viscosity,” is demonstrated. Even though no net particle flux is associated with a heat flux, in a plasma there can still be momentum transport owing to the velocity dependence of the Coulomb collision frequency, analogous to the thermal force. This heat-flux viscosity may play an important role in numerous plasma environments, in particular, in strongly driven high-energy-density plasma, where strong heat flux can dominate over ordinary plasma flows. The heat flux viscosity can influence the dynamics of the magnetic field in plasmas through themore » generalized Ohm's law and may therefore play an important role as a dissipation mechanism allowing magnetic field line reconnection. The heat flux viscosity is calculated directly using the finite-difference method of Epperlein and Haines [Phys. Fluids 29, 1029 (1986)], which is shown to be more accurate than Braginskii's method [S. I. Braginskii, Rev. Plasma Phys. 1, 205 (1965)], and confirmed with one-dimensional collisional particle-in-cell simulations. The resulting transport coefficients are tabulated for ease of application.« less

  1. 77 FR 75973 - Ball Bearings and Parts Thereof From France, Germany, and Italy: Final Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... third columns, the table is corrected to read as set forth below. Margin Company (percent) France: Audi... GmbH 0.00 Robert Bosch GmbH Power Tools and Hagglunds Drives........ 0.00 Italy: Audi AG 0.00 Bosch...

  2. Application of CUSA Excel ultrasonic aspiration system in resection of skull base meningiomas.

    PubMed

    Tang, Hailiang; Zhang, Haishi; Xie, Qing; Gong, Ye; Zheng, Mingzhe; Wang, Daijun; Zhu, Hongda; Chen, Xiancheng; Zhou, Liangfu

    2014-12-01

    Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection. Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old (the mean age was 48.5 years old). Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge. All the patents received total resection of meningiomas with the help of this new tool, and the critical brain vessels and nerves were preserved during operations. All the patients recovered well after operation. This new CUSA Excel ultrasonic aspiration system has the advantage of preserving vital brain arteries and cranial nerves during skull base meningioma resection, which is very important for skull base tumor operations. This key step would ensure a well prognosis for patients. We hope the neurosurgeons would benefit from this kind of technique.

  3. A UML profile for the OBO relation ontology.

    PubMed

    Guardia, Gabriela D A; Vêncio, Ricardo Z N; de Farias, Cléver R G

    2012-01-01

    Ontologies have increasingly been used in the biomedical domain, which has prompted the emergence of different initiatives to facilitate their development and integration. The Open Biological and Biomedical Ontologies (OBO) Foundry consortium provides a repository of life-science ontologies, which are developed according to a set of shared principles. This consortium has developed an ontology called OBO Relation Ontology aiming at standardizing the different types of biological entity classes and associated relationships. Since ontologies are primarily intended to be used by humans, the use of graphical notations for ontology development facilitates the capture, comprehension and communication of knowledge between its users. However, OBO Foundry ontologies are captured and represented basically using text-based notations. The Unified Modeling Language (UML) provides a standard and widely-used graphical notation for modeling computer systems. UML provides a well-defined set of modeling elements, which can be extended using a built-in extension mechanism named Profile. Thus, this work aims at developing a UML profile for the OBO Relation Ontology to provide a domain-specific set of modeling elements that can be used to create standard UML-based ontologies in the biomedical domain.

  4. Hepcidin: an emerging biomarker for iron disorders, inflammatory diseases, and infections

    NASA Astrophysics Data System (ADS)

    Westerman, Mark E.; Olbina, Gordana; Ostland, Vaughn E.; Nemeth, Elizabeta; Ganz, Tomas

    2010-04-01

    The peptide hormone hepcidin, has emerged as the master regulator of iron homeostasis. Dysregulation of hepcidin is a principal or contributing factor in most genetic and acquired systemic iron disorders, including anemia of inflammation (anemia of chronic disease). Hepcidin maintains healthy blood iron levels by regulating dietary iron absorption and transport from body iron stores to plasma. High serum hepcidin levels observed in chronic and acute inflammatory conditions can cause anemia by limiting plasma iron available for erythropoiesis. Chronically low serum hepcidin levels cause iron-overload and ultimately, accumulation of iron in liver and heart. We recently validated the first immunoassay for serum hepcidin and established the normal ranges in adults. Hepcidin has excellent potential as a biomarker and has a known mechanism of action, good stability, and rapid response to iron stores, inflammatory stimuli, and bacterial infections. Hepcidin can be measured in blood, urine, and saliva, and is generally not measurable in iron deficient/anemic patients and highly elevated in inflammatory diseases and infections. Intrinsic LifeSciences (ILS) is developing second generation hepcidin immunoassays and lateral-flow POC devices for hepcidin, a well characterized multi-purpose biomarker with applications in global health security.

  5. On recent advances in human engineering.

    PubMed

    Anton, Roman

    2016-01-01

    Advances in embryology, genetics, and regenerative medicine regularly attract attention from scientists, scholars, journalists, and policymakers, yet implications of these advances may be broader than commonly supposed. Laboratories culturing human embryos, editing human genes, and creating human-animal chimeras have been working along lines that are now becoming intertwined. Embryogenic methods are weaving traditional in vivo and in vitro distinctions into a new "in vivitro" (in life in glass) fabric. These and other methods known to be in use or thought to be in development promise soon to bring society to startling choices and discomfiting predicaments, all in a global effort to supply reliably rejuvenating stem cells, to grow immunologically nonprovocative replacement organs, and to prevent, treat, cure, or even someday eradicate diseases having genetic or epigenetic mechanisms. With humanity's human-engineering era now begun, procedural prohibitions, funding restrictions, institutional controls, and transparency rules are proving ineffective, and business incentives are migrating into the most basic life-sciences inquiries, wherein lie huge biomedical potentials and bioethical risks. Rights, health, and heritage are coming into play with bioethical presumptions and formal protections urgently needing reassessment.

  6. Inorganic nanoparticles for transfection of mammalian cells and removal of viruses from aqueous solutions.

    PubMed

    Link, Nils; Brunner, Tobias J; Dreesen, Imke A J; Stark, Wendelin J; Fussenegger, Martin

    2007-12-01

    Owing to their small size, synthetic nanoparticles show unprecedented biophysical and biochemical properties which may foster novel advances in life-science research. Using flame-spray synthesis technology we have produced non-coated aluminum-, calcium-, cerium-, and zirconium-derived inorganic metal oxide nanoparticles which not only exhibit high affinity for nucleic acids, but can sequester such compounds from aqueous solution. This non-covalent DNA-binding capacity was successfully used to transiently transfect a variety of mammalian cells including human, reaching transfection efficiencies which compared favorably with classic calcium phosphate precipitation (CaP) procedures and lipofection. In this straightforward protocol, transfection was enabled by simply mixing nanoparticles with DNA in solution prior to addition to the target cell population. Transiently transfected cells showed higher production levels of the human secreted glycoprotein SEAP compared to isogenic populations transfected with established technologies. Inorganic metal oxide nanoparticles also showed a high binding capacity to human-pathogenic viruses including adenovirus, adeno-associated virus and human immunodeficiency virus type 1 and were able to clear these pathogens from aqueous solutions. The DNA transfection and viral clearance capacities of inorganic metal oxide nanoparticles may provide cost-effective biopharmaceutical manufacturing and water treatment in developing countries.

  7. Microorganisms: Good or Evil, MIRRI Provides Biosecurity Awareness.

    PubMed

    Smith, David; Martin, Dunja; Novossiolova, Tatyana

    2017-03-01

    The life-science community is a key stakeholder in the effort to ensure that the advances in biotechnology are not misused. Unfortunately, to date, the engagement of life scientists with issues of biosecurity has been limited. Microorganisms have been harnessed for the benefit of humankind but in the wrong hands could be used in direct or indirect acts against humans, livestock, crops, food, water infrastructure and other economically valuable entities. The Microbial Resources Research Infrastructure in its preparatory phase has addressed the topic implementing a code of conduct as part of its programme of prevention of malicious use and continues to work with the international community to raise awareness of best practice to avoid misuse of microorganisms. Biosecurity has become a major concern for several countries creating numerous activities to put in place counter measures, risk assessment, legislation and emergency response. The goal is to implement measures to protect us against malicious use of microorganisms, their products, information and technology transfer. Through this paper, we wish to discuss some of the activities that are underway, mention key educational tools and provide scientists with information on addressing biosecurity issues.

  8. On recent advances in human engineering Provocative trends in embryology, genetics, and regenerative medicine.

    PubMed

    Anton, Roman

    2016-01-01

    Advances in embryology, genetics, and regenerative medicine regularly attract attention from scientists, scholars, journalists, and policymakers, yet implications of these advances may be broader than commonly supposed. Laboratories culturing human embryos, editing human genes, and creating human-animal chimeras have been working along lines that are now becoming intertwined. Embryogenic methods are weaving traditional in vivo and in vitro distinctions into a new "in vivitro" (in life in glass) fabric. These and other methods known to be in use or thought to be in development promise soon to bring society to startling choices and discomfiting predicaments, all in a global effort to supply reliably rejuvenating stem cells, to grow immunologically non-provocative replacement organs, and to prevent, treat, cure, or even someday eradicate diseases having genetic or epigenetic mechanisms. With humanity's human-engineering era now begun, procedural prohibitions, funding restrictions, institutional controls, and transparency rules are proving ineffective, and business incentives are migrating into the most basic life-sciences inquiries, wherein lie huge biomedical potentials and bioethical risks. Rights, health, and heritage are coming into play with bioethical presumptions and formal protections urgently needing reassessment.

  9. Learning physical biology via modeling and simulation: A new course and textbook for science and engineering undergraduates

    NASA Astrophysics Data System (ADS)

    Nelson, Philip

    To a large extent, undergraduate physical-science curricula remain firmly rooted in pencil-and-paper calculation, despite the fact that most research is done with computers. To a large extent, undergraduate life-science curricula remain firmly rooted in descriptive approaches, despite the fact that much current research involves quantitative modeling. Not only does our pedagogy not reflect current reality; it also creates a spurious barrier between the fields, reinforcing the narrow silos that prevent students from connecting them. I'll describe an intermediate-level course on ``Physical Models of Living Systems.'' The prerequisite is first-year university physics and calculus. The course is a response to rapidly growing interest among undergraduates in a broad range of science and engineering majors. Students acquire several research skills that are often not addressed in traditional undergraduate courses: •Basic modeling skills; •Probabilistic modeling skills; •Data analysis methods; •Computer programming using a general-purpose platform like MATLAB or Python; •Pulling datasets from the Web for analysis; •Data visualization; •Dynamical systems, particularly feedback control. Partially supported by the NSF under Grants EF-0928048 and DMR-0832802.

  10. Nearly Blinking-Free, High-Purity Single-Photon Emission by Colloidal InP/ZnSe Quantum Dots.

    PubMed

    Chandrasekaran, Vigneshwaran; Tessier, Mickaël D; Dupont, Dorian; Geiregat, Pieter; Hens, Zeger; Brainis, Edouard

    2017-10-11

    Colloidal core/shell InP/ZnSe quantum dots (QDs), recently produced using an improved synthesis method, have a great potential in life-science applications as well as in integrated quantum photonics and quantum information processing as single-photon emitters. Single-particle spectroscopy of 10 nm QDs with 3.2 nm cores reveals strong photon antibunching attributed to fast (70 ps) Auger recombination of multiple excitons. The QDs exhibit very good photostability under strong optical excitation. We demonstrate that the antibunching is preserved when the QDs are excited above the saturation intensity of the fundamental-exciton transition. This result paves the way toward their usage as high-purity on-demand single-photon emitters at room temperature. Unconventionally, despite the strong Auger blockade mechanism, InP/ZnSe QDs also display very little luminescence intermittency ("blinking"), with a simple on/off blinking pattern. The analysis of single-particle luminescence statistics places these InP/ZnSe QDs in the class of nearly blinking-free QDs, with emission stability comparable to state-of-the-art thick-shell and alloyed-interface CdSe/CdS, but with improved single-photon purity.

  11. 76 FR 80829 - Special Conditions: XtremeAir GmbH, XA42; Acrobatic Category Aerodynamic Stability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... at the highest level of aerobatic competition. To be competitive, the aircraft was designed with... envelope to accommodate the increased fuel load designed for cross-country operations. The FAA does recognize that fuel exhaustion is one of the top accident causes associated with this class of aircraft. For...

  12. 77 FR 17323 - Special Conditions: XtremeAir GmbH, XA42; Acrobatic Category Aerodynamic Stability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ... highest level of aerobatic competition. To be competitive, the aircraft was designed with positive and, at... increased fuel load designed for cross-country operations. The FAA does recognize that fuel exhaustion is... airplane would also be approved at some higher weight (for fuel) that would still meet the requirements of...

  13. 75 FR 68179 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ...We are adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory continuing airworthiness information (MCAI) issued by an aviation authority of another country to identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as:

  14. 76 FR 33660 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ...We propose to supersede an existing airworthiness directive (AD) that applies to the products listed above. The existing AD currently requires frequent inspections of the fuel pressure supply for excessive oscillations to determine if high-pressure fuel pumps have been exposed to damaging pressure oscillations. Pumps that have been exposed require replacement before further flight. Since we issued that AD, Austro Engine, the manufacturer of the pump, introduced a new part number (P/N) fuel pump as mandatory terminating action to the repetitive inspections. This proposed AD would require the initial and repetitive inspections of AD 2010-23-09, but would also require installing HP fuel pump P/N E4A-30-200-000, as mandatory terminating action to the repetitive inspections. We are proposing this AD to prevent engine power loss or in-flight shutdown, which could result in loss of control of the airplane.

  15. 76 FR 54373 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ...We are superseding an existing airworthiness directive (AD) for the products listed above. That AD currently requires frequent inspections of the fuel pressure supply for excessive oscillations to determine if high-pressure (HP) fuel pumps have been exposed to damaging pressure oscillations. Pumps that have been exposed require replacement before further flight. This new AD requires the initial and repetitive inspections of AD 2010-23-09, but also requires installing HP fuel pump part number (P/N) E4A-30-200-000, as mandatory terminating action to the repetitive inspections. We are issuing this AD to prevent engine power loss or in-flight shutdown, which could result in loss of control of the airplane.

  16. 76 FR 37684 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model (Diamond) DA 40 Airplanes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... the airplane weight and balance. This proposed AD was prompted by reports of damage around the VCS... balance. Authority for This Rulemaking Title 49 of the United States Code specifies the FAA's authority to... weight and balance. Special Flight Permit (h) The compressor drive belt must be cut and removed before...

  17. 76 FR 22078 - Lightweight Thermal Paper From Germany: Notice of Final Results of the First Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-428-840] Lightweight Thermal Paper... initiation of this antidumping duty administrative review naming Mitsubishi HiTec Paper Flensburg GmbH, Mitsubishi HiTec Paper Bielefeld GmbH and Mitsubishi International Corporation (``collectively, Mitsubishi...

  18. 77 FR 77091 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Certain Balloon Dissection Devices and Products Containing Same, DN 2925; the Commission is soliciting... importation of certain balloon dissection devices and products containing same. The complaint names as respondents Pajunk Medizintechnik GmbH of Germany, Pajunk Medizintechnolgie GmbH of Germany and Pajunk Medical...

  19. Modelling the Effects of Temperature and Cloud Cover Change on Mountain Permafrost Distribution, Northwest Canada

    NASA Astrophysics Data System (ADS)

    Bonnaventure, P. P.; Lewkowicz, A. G.

    2008-12-01

    Spatial models of permafrost probability for three study areas in northwest Canada between 59°N and 61°N were perturbed to investigate climate change impacts. The models are empirical-statistical in nature, based on basal temperature of snow (BTS) measurements in winter, and summer ground-truthing of the presence or absence of frozen ground. Predictions of BTS values are made using independent variables of elevation and potential incoming solar radiation (PISR), both derived from a 30 m DEM. These are then transformed into the probability of the presence or absence of permafrost through logistic regression. Under present climate conditions, permafrost percentages in the study areas are 44% for Haines Summit, British Columbia, 38% for Wolf Creek, Yukon, and 69% for part of the Ruby Range, Yukon (Bonnaventure and Lewkowicz, 2008; Lewkowicz and Bonaventure, 2008). Scenarios of air temperature change from -2K (approximating Neoglacial conditions) to +5K (possible within the next century according to the IPCC) were examined for the three sites. Manipulations were carried out by lowering or raising the terrain within the DEM assuming a mean environmental lapse rate of 6.5K/km. Under a -2K scenario, permafrost extent increased by 22-43% in the three study areas. Under a +5K warming, permafrost essentially disappeared in Haines Summit and Wolf Creek, while in the Ruby Range less than 12% of the area remained perennially frozen. It should be emphasized that these model predictions are for equilibrium conditions which might not be attained for several decades or longer in areas of cold permafrost. Cloud cover changes of -10% to +10% were examined through adjusting the partitioning of direct beam and diffuse radiation in the PISR input field. Changes to permafrost extent were small, ranging from -2% to -4% for greater cloudiness with changes of the opposite magnitude for less cloud. The results show that air temperature change has a much greater potential to affect mountain

  20. Determination of discharge during pulsating flow

    USGS Publications Warehouse

    Thompson, T.H.

    1968-01-01

    Pulsating flow in an open channel is a manifestation of unstable-flow conditions in which a series of translatory waves of perceptible magnitude develops and moves rapidly downstream. Pulsating flow is a matter of concern in the design and operation of steep-gradient channels. If it should occur at high stages in a channel designed for stable flow, the capacity of the channel may be inadequate at a discharge that is much smaller than that for which the channel was designed. If the overriding translatory wave carries an appreciable part of the total flow, conventional stream-gaging procedures cannot be used to determine the discharge; neither the conventional instrumentation nor conventional methodology is adequate. A method of determining the discharge during pulsating flow was tested in the Santa Anita Wash flood control channel in Arcadia, Calif., April 16, 1965. Observations of the dimensions and velocities of translatory waves were made during a period of controlled reservoir releases of about 100, 200, and 300 cfs (cubic feet per second). The method of computing discharge was based on (1) computation of the discharge in the overriding waves and (2) computation of the discharge in the shallow-depth, or overrun, part of the flow. Satisfactory results were obtained by this method. However, the procedure used-separating the flow into two components and then treating the shallow-depth component as though it were steady--has no theoretical basis. It is simply an expedient for use until laboratory investigation can provide a satisfactory analytical solution to the problem of computing discharge during pulsating flow. Sixteen months prior to the test in Santa Anita Wash, a robot camera had been designed .and programmed to obtain the data needed to compute discharge by the method described above. The photographic equipment had been installed in Haines Creek flood control channel in Los Angeles, Calif., but it had not been completely tested because of the infrequency of

  1. 77 FR 32507 - Brass Sheet and Strip From Germany: Notice of Rescission of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... Germany: Notice of Rescission of Antidumping Duty Administrative Review AGENCY: Import Administration... and strip from Germany for the period of review (``POR''), March 1, 2011, through February 29, 2012.\\1... brass sheet and strip from Germany: Aurubis Stolberg GmbH & Co. KG (``Aurubis''), Carl Schreiber GmbH...

  2. 76 FR 48047 - Airworthiness Directives; Diamond Aircraft Industries Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... 5 p.m., Monday through Friday, except Federal holidays. For service information identified in this... Service Information Diamond Aircraft Industries GmbH has issued Service Bulletin No. MSB 36-105/1, dated...-105, dated April 21, 2011, as specified in Diamond Aircraft Industries GmbH Service Bulletin No. MSB...

  3. 76 FR 19903 - Special Conditions: Diamond Aircraft Industry Model DA-40NG; Diesel Cycle Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... DA-40NG the Austro Engine GmbH model E4 aircraft diesel engine (ADE) using turbine (jet) fuel. This... engine utilizing turbine (jet) fuel. The applicable airworthiness regulations do not contain adequate or...: Installation of the Austro Engine GmbH Model E4 ADE diesel engine utilizing turbine (jet) fuel. Discussion...

  4. 76 FR 52937 - Ball Bearings and Parts Thereof From France, Germany, and Italy: Final Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... programming and other errors in the margin calculations. Therefore, the final results are different from the... certain companies. We have corrected programming and other errors in the margins we included in the... Technologies GmbH; Italy--Schaeffler Italia S.r.l./WPB Water Pump Bearing GmbH & Co. KG/The Schaeffler Group...

  5. 75 FR 30280 - Airworthiness Directives; Stemme GmbH & Co. KG Model S10-VT Powered Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... metal. Since its publication, another fuel leakage has been reported on a S10-VT which had implemented... Installation of a Stainless Steel T- and Y- Connector in the Fuel System in Lieu of a Zinc Metal T- and Y... fitting instead of the zinc metal connector specified in STEMME F & D Service Bulletin A31-10-083, Am...

  6. 75 FR 7947 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Model TAE 125-01 Reciprocating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Operations office is located at Docket Management Facility, U.S. Department of Transportation, 1200 New...

  7. 75 FR 66657 - Airworthiness Directives; Eurocopter Deutschland GmbH Model MBB-BK 117 C-2 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... of dynamic weights, severe vibration, and subsequent loss of control of the helicopter. DATES... that are intended to prevent separation of dynamic weights, severe vibration, and subsequent loss of... MCAI AD states there was an in- flight incident in which a dynamic weight broke off the [[Page 66658...

  8. 78 FR 32576 - Proposed Airworthiness Design Standards; AQUILA Aviation by Excellence GmbH, Model AT01

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... aeroplanes, each power or thrust control must be designed so that if the control separates at the engine fuel... control toward lean or shut-off position. (b) Each manual engine mixture control must be designed so that... any generator; and (5) Each generator must have an overvoltage control designed and installed to...

  9. One Burn, One Standard

    DTIC Science & Technology

    2014-09-01

    Johannes Kepler University Linz Software GmbH Research Department Medical Informatics Hagenberg, Austria Herbert L. Haller, MD Trauma Hospital Linz of...0000000000000004 Address correspondence to M. Giretzlehner, PhD, Johannes Kepler University Linz, RISC Software GmbH, Research Department Medical Informatics, Softwarepark 35, 4232 Hagenberg, Austria. One Burn, One Standard LETTER TO THE EDITOR

  10. A level set method for determining critical curvatures for drainage and imbibition.

    PubMed

    Prodanović, Masa; Bryant, Steven L

    2006-12-15

    An accurate description of the mechanics of pore level displacement of immiscible fluids could significantly improve the predictions from pore network models of capillary pressure-saturation curves, interfacial areas and relative permeability in real porous media. If we assume quasi-static displacement, at constant pressure and surface tension, pore scale interfaces are modeled as constant mean curvature surfaces, which are not easy to calculate. Moreover, the extremely irregular geometry of natural porous media makes it difficult to evaluate surface curvature values and corresponding geometric configurations of two fluids. Finally, accounting for the topological changes of the interface, such as splitting or merging, is nontrivial. We apply the level set method for tracking and propagating interfaces in order to robustly handle topological changes and to obtain geometrically correct interfaces. We describe a simple but robust model for determining critical curvatures for throat drainage and pore imbibition. The model is set up for quasi-static displacements but it nevertheless captures both reversible and irreversible behavior (Haines jump, pore body imbibition). The pore scale grain boundary conditions are extracted from model porous media and from imaged geometries in real rocks. The method gives quantitative agreement with measurements and with other theories and computational approaches.

  11. The Ohio State 1991 geopotential and sea surface topography harmonic coefficient models

    NASA Technical Reports Server (NTRS)

    Rapp, Richard H.; Wang, Yan Ming; Pavlis, Nikolaos K.

    1991-01-01

    The computation is described of a geopotential model to deg 360, a sea surface topography model to deg 10/15, and adjusted Geosat orbits for the first year of the exact repeat mission (ERM). This study started from the GEM-T2 potential coefficient model and it's error covariance matrix and Geosat orbits (for 22 ERMs) computed by Haines et al. using the GEM-T2 model. The first step followed the general procedures which use a radial orbit error theory originally developed by English. The Geosat data was processed to find corrections to the a priori geopotential model, corrections to a radial orbit error model for 76 Geosat arcs, and coefficients of a harmonic representation of the sea surface topography. The second stage of the analysis took place by doing a combination of the GEM-T2 coefficients with 30 deg gravity data derived from surface gravity data and anomalies obtained from altimeter data. The analysis has shown how a high degree spherical harmonic model can be determined combining the best aspects of two different analysis techniques. The error analysis was described that has led to the accuracy estimates for all the coefficients to deg 360. Significant work is needed to improve the modeling effort.

  12. Eastern Denali Fault surface trace map, eastern Alaska and Yukon, Canada

    USGS Publications Warehouse

    Bender, Adrian M.; Haeussler, Peter J.

    2017-05-04

    We map the 385-kilometer (km) long surface trace of the right-lateral, strike-slip Denali Fault between the Totschunda-Denali Fault intersection in Alaska, United States and the village of Haines Junction, Yukon, Canada. In Alaska, digital elevation models based on light detection and ranging and interferometric synthetic aperture radar data enabled our fault mapping at scales of 1:2,000 and 1:10,000, respectively. Lacking such resources in Yukon, we developed new structure-from-motion digital photogrammetry products from legacy aerial photos to map the fault surface trace at a scale of 1:10,000 east of the international border. The section of the fault that we map, referred to as the Eastern Denali Fault, did not rupture during the 2002 Denali Fault earthquake (moment magnitude 7.9). Seismologic, geodetic, and geomorphic evidence, along with a paleoseismic record of past ground-rupturing earthquakes, demonstrate Holocene and contemporary activity on the fault, however. This map of the Eastern Denali Fault surface trace complements other data sets by providing an openly accessible digital interpretation of the location, length, and continuity of the fault’s surface trace based on the accompanying digital topography dataset. Additionally, the digitized fault trace may provide geometric constraints useful for modeling earthquake scenarios and related seismic hazard.

  13. Enhanced Cr bioleaching efficiency from tannery sludge with coinoculation of Acidithiobacillus thiooxidans TS6 and Brettanomyces B65 in an air-lift reactor.

    PubMed

    Fang, Di; Zhou, Li-Xiang

    2007-09-01

    Bioleaching process has been demonstrated to be an effective technology in removing Cr from tannery sludge, but a large quantity of dissolved organic matter (DOM) present in tannery sludge often exhibits a marked toxicity to chemolithoautotrophic bioleaching bacteria such as Acidithiobacillus thiooxidans. The purpose of the present study was therefore to enhance Cr bioleaching efficiencies through introducing sludge DOM-degrading heterotrophic microorganism into the sulfur-based sludge bioleaching system. An acid-tolerant DOM-degrading yeast strain Brettanomyces B65 was successfully isolated from a local Haining tannery sludge and it could metabolize sludge DOM as a source of energy and carbon for growth. A combined bioleaching experiment (coupling Brettanomyces B65 and A. thiooxidans TS6) performed in an air-lift reactor indicated that the rates of sludge pH reduction and ORP increase were greatly improved, resulting in enhanced Cr solubilization. Compared with the 5 days required for maximum solubilization of Cr for the control (single bioleaching process without inoculation of Brettanomyces B65), the bioleaching period was significantly shorten to 3 days for the combined bioleaching system. Moreover, little nitrogen and phosphorous were lost and the content of Cr was below the permitted levels for land application after 3 days of bioleaching treatment.

  14. Compact and low-cost humanoid hand powered by nylon artificial muscles.

    PubMed

    Wu, Lianjun; Jung de Andrade, Monica; Saharan, Lokesh Kumar; Rome, Richard Steven; Baughman, Ray H; Tadesse, Yonas

    2017-02-03

    This paper focuses on design, fabrication and characterization of a biomimetic, compact, low-cost and lightweight 3D printed humanoid hand (TCP Hand) that is actuated by twisted and coiled polymeric (TCP) artificial muscles. The TCP muscles were recently introduced and provided unprecedented strain, mechanical work, and lifecycle (Haines et al 2014 Science 343 868-72). The five-fingered humanoid hand is under-actuated and has 16 degrees of freedom (DOF) in total (15 for fingers and 1 at the palm). In the under-actuated hand designs, a single actuator provides coupled motions at the phalanges of each finger. Two different designs are presented along with the essential elements consisting of actuators, springs, tendons and guide systems. Experiments were conducted to investigate the performance of the TCP muscles in response to the power input (power magnitude, type of wave form such as pulsed or square wave, and pulse duration) and the resulting actuation stroke and force generation. A kinematic model of the flexor tendons was developed to simulate the flexion motion and compare with experimental results. For fast finger movements, short high-power pulses were employed. Finally, we demonstrated the grasping of various objects using the humanoid TCP hand showing an array of functions similar to a natural hand.

  15. The Effect of an Energy Audit Service Learning Project on Student Perceptions of STEM Related Disciplines, Personal Behaviors/Actions towards the Environment, and Stewardship Skills

    NASA Astrophysics Data System (ADS)

    Gullo, Michael

    The purpose of this study was to investigate whether or not service learning could be considered an alternative teaching method in an environmental science classroom. In particular, the results of this research show whether an energy audit service learning project influenced student environmental awareness (knowledge of environmental issues, problems, and solutions), student personal actions/behaviors towards the environment, student perceptions and attitudes of science related careers, and community partnerships. Haines (2010) defines service learning as “a teaching and learning strategy that integrates meaningful community service with instruction and reflection to enrich the learning experience, teach civic responsibility, and strengthen communities” (p. 16). Moreover, service learning opportunities can encourage students to step out of their comfort zone and learn from hands-on experiences and apply knowledge obtained from lectures and classroom activities to real life situations. To add to the growing body of literature, the results of this study concluded that an energy audit service learning project did not have a measureable effect on student perceptions and attitudes of science related careers as compared to a more traditional teaching approach. However, the data from this study did indicate that an energy audit service learning project increased students personal actions/behaviors towards the environment more than a direct teaching approach.

  16. In-Graft Endovascular Stenting Repair for Supravalvular Stenosis From Aortic Rupture After Balloon-Expanding Transcatheter Aortic Valve Implantation.

    PubMed

    Furukawa, Nobuyuki; Scholtz, Werner; Haas, Nikolaus; Ensminger, Stephan; Gummert, Jan; Börgermann, Jochen

    2015-01-01

    An 81-year-old man with high-grade aortic valve stenosis and status post-coronary artery bypass grafting and supracoronary replacement of the ascending aorta was referred for transcatheter aortic valve implantation. He was in New York Heart Association class III and had dyspnea. After appropriate screening, we implanted a 29-mm SAPIEN XT valve (Edwards Lifesciences, Irvine, CA USA) through a transapical approach because of severe peripheral arterial occlusive disease. Postinterventional aortography revealed correct positioning and function of the valve and free coronary ostia but contrast extravasation in the vicinity of the interposed vascular prosthesis, resulting in severe luminal narrowing. We chose to manage the stenosis with an endovascular stent. After stenting, extravascular compression was markedly reduced, and the pressure gradient disappeared. The patient was discharged home on the 20th postoperative day. Three months later, computed tomography depicted correct positioning of both grafts. The patient's general health is good, and he is now in New York Heart Association class II. This case illustrates a complication of transcatheter aortic valve implantation specific for patients with an ascending aortic graft. Although stenting may be a good solution, as depicted by this case, self-expanding transcatheter aortic valves should be preferred in patients with ascending aortic grafts to avoid the described complication.

  17. Application of CUSA Excel ultrasonic aspiration system in resection of skull base meningiomas

    PubMed Central

    Tang, Hailiang; Zhang, Haishi; Xie, Qing; Zheng, Mingzhe; Wang, Daijun; Zhu, Hongda; Chen, Xiancheng; Zhou, Liangfu

    2014-01-01

    Background Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection. Methods Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old (the mean age was 48.5 years old). Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge. Results All the patents received total resection of meningiomas with the help of this new tool, and the critical brain vessels and nerves were preserved during operations. All the patients recovered well after operation. Conclusions This new CUSA Excel ultrasonic aspiration system has the advantage of preserving vital brain arteries and cranial nerves during skull base meningioma resection, which is very important for skull base tumor operations. This key step would ensure a well prognosis for patients. We hope the neurosurgeons would benefit from this kind of technique. PMID:25561762

  18. Space Tweetup - from a participant to a Mars Tweetup organizer and a new format of space communication

    NASA Astrophysics Data System (ADS)

    Haider, O.; Groemer, G.

    2014-01-01

    In September 2011, the European Space Agency (ESA) and the German Space Agency (DLR) organized the first European SpaceTweetup during the German Aerospace day. One of the authors was one of 60 participants at this SpaceTweetup in Cologne and experienced the concept of a Tweetup and the engagement of the participants from the inside view. Building upon this experience, the Austrian Space Forum (OeWF) organized the first Austrian MarsTweetup during the “Dachstein Mars analog simulation”. Between 27 Apr,2001 and May,2012, a five day Mars simulation was conducted by the Austrian Space Forum and international research partners at the Giant Ice caves at the Dachstein region in Austria. During this field test, the Aouda.X spacesuit simulator and selected geophysical and life-science related experiments were conducted. In this paper we outline the potential and limitations of social media and how to engage the general public to participate and communicate about space projects through their own experience. We show examples of material SpaceTweetup participants produced e.g. hundreds of tweets during the actual event, blog entries, photo galleries and how space communication can benefit from it. Our considerations on organizing a SpaceTweetup are complemented with a section on lessons learned.

  19. Synchrotron Microtomography Reveals the Fine Three-Dimensional Porosity of Composite Polysaccharide Aerogels

    PubMed Central

    Ghafar, Abdul; Parikka, Kirsti; Tenkanen, Maija; Suuronen, Jussi-Petteri

    2017-01-01

    This study investigates the impact of ice-templating conditions on the morphological features of composite polysaccharide aerogels in relation to their mechanical behavior and aims to get a better insight into the parameters governing these properties. We have prepared polysaccharide aerogels of guar galactomannan (GM) and tamarind seed xyloglucan (XG) by enzymatic oxidation with galactose oxidase (GaO) to form hydrogels, followed by conventional and unidirectional ice-templating (freezing) methods and lyophilization to form aerogels. Composite polysaccharide aerogels were prepared by incorporating nanofibrillated cellulose (NFC) into polysaccharide solutions prior to enzymatic oxidation and gel formation; such a cross linking technique enabled the homogeneous distribution of the NFC reinforcement into the gel matrix. We conducted phase-enhanced synchrotron X-ray microtomography (XMT) scans and visualized the internal microstructure of the aerogels in three-dimensional (3D) space. Volume-weighted pore-size and pore-wall thickness distributions were quantitatively measured and correlated to the aerogels’ mechanical properties regarding ice-templating conditions. Pore-size distribution and orientation depended on the ice-templating methods and the NFC reinforcement that significantly determined the mechanical and shape-recovery behavior of the aerogels. The results obtained will guide the design of the microporous structure of polysaccharide aerogels with optimal morphology and mechanical behavior for life-sciences applications. PMID:28773235

  20. The European Bioinformatics Institute in 2017: data coordination and integration

    PubMed Central

    Cochrane, Guy; Apweiler, Rolf; Birney, Ewan

    2018-01-01

    Abstract The European Bioinformatics Institute (EMBL-EBI) supports life-science research throughout the world by providing open data, open-source software and analytical tools, and technical infrastructure (https://www.ebi.ac.uk). We accommodate an increasingly diverse range of data types and integrate them, so that biologists in all disciplines can explore life in ever-increasing detail. We maintain over 40 data resources, many of which are run collaboratively with partners in 16 countries (https://www.ebi.ac.uk/services). Submissions continue to increase exponentially: our data storage has doubled in less than two years to 120 petabytes. Recent advances in cellular imaging and single-cell sequencing techniques are generating a vast amount of high-dimensional data, bringing to light new cell types and new perspectives on anatomy. Accordingly, one of our main focus areas is integrating high-quality information from bioimaging, biobanking and other types of molecular data. This is reflected in our deep involvement in Open Targets, stewarding of plant phenotyping standards (MIAPPE) and partnership in the Human Cell Atlas data coordination platform, as well as the 2017 launch of the Omics Discovery Index. This update gives a birds-eye view of EMBL-EBI’s approach to data integration and service development as genomics begins to enter the clinic. PMID:29186510

  1. The National Shipbuilding Research Program. Evaluation of Shipbuilding CAD/CAM Systems (Phase I)

    DTIC Science & Technology

    1996-10-14

    Industries Norddeutsche Itiormations Systems GmbH Odense Steel Shipyard Sener Ingenieria y Sistemas SMK Ingenieurburo Verolrne Scheepswerf Heusden b.v...Systems Logimatic Marine Consultants A/S Mitsubishi Heavy Industries Norddeutsche Informations Systems GmbH Odense Steel Shipyard Sener Ingenieria y...market share and business backlog . continue profitable operation in spite of relentless price and schedule competition 11.0 SENERMAR Sener Ingenieria

  2. Haines Board: A Review of Army School System for Officer Education and Training. USAIS Position. Volume 1 and Factual Data. Volume 2

    DTIC Science & Technology

    1965-07-01

    currently not suitable for general publica - tion, but which, because of their implication in the future, merit the atten- tion of senior Infantry...OC selection and evaluation, sug- gestions on departmental organization, evaluation of officer students, course prerequisites, attrition

  3. 76 FR 61638 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... accepted during the latest Candidate Maintenance Coordination Committee meeting. This review resulted in... maintenance requirements] CMR** repetitive inspections, which have been identified as mandatory actions for... Maintenance Coordination Committee meeting. This review resulted in reduced inspection intervals, specifically...

  4. 76 FR 419 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... cracking was identified as stress corrosion. This condition, if not corrected, could lead to in-flight... identified as stress corrosion. This condition, if not corrected, could lead to in-flight failure of the tab..., using a material that is more resistant to stress corrosion. The improved material rudder spring tab...

  5. 75 FR 60659 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... identified as stress corrosion. This condition, if not corrected, could lead to in-flight failure of the tab... was found on a trim tab fitting assembly. The cause of the cracking was identified as stress corrosion... is more resistant to stress corrosion. The improved material rudder spring tab fittings were...

  6. 76 FR 68299 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 C-2 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ...: Starter-Generator, 2437: DC Indicating System, and 2430: DC Generator System. (d) Revise the Emergency... Performance Data sections of the RFM to alert the operators to monitor the power display when a generator is... when one generator is deactivated. The actions specified in this AD are intended to prevent failure of...

  7. 76 FR 6523 - Airworthiness Directives; Dornier Luftfahrt GmbH Models Dornier 228-100, Dornier 228-101, Dornier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... initiated a flight-test campaign including strain measurements as well as finite element modelling and... including strain measurements as well as finite element modelling and fatigue analyses to better understand..., the TC Holder also initiated a flight-test campaign including strain measurements as well as finite...

  8. 75 FR 70623 - Airworthiness Directives; DORNIER LUFTFAHRT GmbH Models Dornier 228-100, Dornier 228-101, Dornier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... measurements as well as finite element modelling and fatigue analyses to better understand the stress... include strain measurements as well as finite element modeling and fatigue analyses to better understand... finite element modelling and fatigue analyses to better understand the stress distribution onto the frame...

  9. 75 FR 7949 - Airworthiness Directives; Extra Flugzeugproduktions- und Vertriebs- GmbH Models EA-300/200 and EA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final... Facility, U.S. Department of Transportation, Docket Operations, M-30, West Building Ground Floor, Room W12...

  10. 77 FR 71593 - Robert Bosch GmbH; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... state identification number or foreign country equivalent, passport number, financial account number, or... for licensing certain patents which may be used in the implementation of two industry standards... elimination of the direct competition between Robinair and Bosch would allow the combined entity to exercise...

  11. 75 FR 48617 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 C-2 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... separation of dynamic weights, severe vibration, and subsequent loss of control of the helicopter. Actions... in-flight incident in which a dynamic weight broke off the control lever leading to considerable... proposed actions are intended to prevent separation of dynamic weights, severe vibration, and subsequent...

  12. 76 FR 58094 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... subsequent Eddy Current inspection (NDI) [non-destructive inspection] of the same area to detect cracks... inspections are eddy current inspections. The modification includes cold expansion of the former lower wing... with consequent loss of control. * * * * * The new inspections are eddy current inspections. The...

  13. The use of computed tomography scans and the Bender Gestalt Test in the assessment of competency to stand trial and criminal responsibility in the field of mental health and law.

    PubMed

    Mosotho, Nathaniel Lehlohonolo; Timile, Ino; Joubert, Gina

    computed tomography and the Bender Gestalt Test are some of the tests used routinely for the assessment of alleged offenders referred under Sections 77 and 78 of the Criminal Procedure Act 51 of 1977. An exploratory retrospective study was conducted at the Free State Psychiatric Complex. The aim of this study was to identify the extent to which the Bender Gestalt Test results and the computed tomography scans are associated with outcomes in the assessment of competency to stand trial and criminal responsibility in individuals referred to the Free State Psychiatric Complex (FSPC) observation unit. This was a cross-sectional study and the entire population of patients admitted in 2013 was included in the study. The clinical and demographic data were obtained from patient files. The majority of participants were black, males, single and unemployed. The most common diagnosis was schizophrenia. The current study showed no statistically significant association between the Bender Gestalt Test Hain's scores and the outcome of criminal responsibility and competency to stand trial. Similarly, the study also showed no statistically significant association between the presence of a brain lesion and the outcome of criminal responsibility and competency to stand trial. It was also concluded that as CT scans are expensive, patients should be referred for that service only when there is a clear clinical indication to do so. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. The utility of trans-catheter aortic valve replacement after commercialization: does the European experience provide a glimpse into the future use of this technology in the United States?

    PubMed

    Linke, Axel; Walther, Thomas; Schuler, Gerhard

    2010-03-01

    Treatment of aortic stenosis remains challenging in older individuals, as their perioperative mortality for open heart surgery is increased due to comorbidities. Transcatheter aortic valve implantation using the CoreValve ReValving System (Medtronic, Minneapolis, USA) and the Edwards SAPIEN transcatheter heart valve (THV; Edwards Lifescience, Irvine, California, USA) represents an alternative to conventional valve replacement in elderly patients that have a high risk for conventional surgery. This article summarizes the evidence-base from recent clinical trials. The early results of these landmark studies suggest that transcatheter aortic valve implantation with either one of the prosthesis is feasible, safe, improves hemodynamics and, therefore, might be an alternative to conventional aortic valve replacement in very high-risk patients. However, all of the available transcatheter heart valves have certain disadvantages, limiting their use in daily clinical practice. The process of decision making, which valve to use and which access route to choose is illustrated in this article through clinical case scenarios. Additionally, the lessons learned thus far from the European perspective and the potential impact on the future use in the US are discussed. Despite of the progress in this field, we are still lacking an optimal transcatheter heart valve. Once it is available, we can take the plunge to compare transcatheter valve implantation with convention surgery in severe aortic stenosis!

  15. What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold.

    PubMed

    MacEwan, Matthew R; MacEwan, Sarah; Kovacs, Tamas R; Batts, Joel

    2017-10-02

    Wound matrix materials are used to improve the regeneration of dermal and epidermal layers in both acute and chronic wounds. Contemporary wound matrices are primarily composed of biologic materials such as processed xenogeneic and allogeneic tissues. Unfortunately, existing biologic wound matrices possess multiple limitations including poor longevity, durability, strength, and enzymatic resistance required for persistent support for new tissue formation. A fully-synthetic, resorbable electrospun material (Restrata Wound Matrix, Acera, St.Louis, Missouri ) that exhibits structural similarities to the native extracellular matrix offers a new approach to the treatment of acute and chronic wounds. This novel matrix is the first product to combine the advantages of synthetic construction (e.g. resistance to enzymatic degradation, excellent biocompatibility, strength/durability and controlled degradation) with the positive attributes of biologic materials (e.g. biomimetic architecture similar to human extracellular matrix (ECM), fibrous architecture optimized to support cellular migration and proliferation, engineered porosity to encourage tissue ingrowth and vascularization). These features allow RWM to achieve rapid and complete healing of full-thickness wounds that, in preclinical studies, is comparable to Integra Bilayer Wound Matrix (Integra LifeSciences, Plainsboro, New Jersey), a gold standard biologic material with diverse clinical indications in the wound care. Together, this review suggests that the RWM offers a unique fully-synthetic alternative to existing biologic matrices that is effective, widely available, easy to store, simple to apply and low cost.

  16. Collaborative vaccine development: partnering pays.

    PubMed

    Ramachandra, Rangappa

    2008-01-01

    Vaccine development, supported by infusions of public and private venture capital, is re-entering a golden age as one of the fastest growing sectors in the life-sciences industry. Demand is driven by great unmet need in underdeveloped countries, increased resistance to current treatments, bioterrorism, and for prevention indications in travelers, pediatric, and adult diseases. Production systems are becoming less reliant on processes such as egg-based manufacturing, while new processes can help to optimize vaccines. Expeditious development hinges on efficient study conduct, which is greatly enhanced through research partnerships with specialized contract research organizations (CROs) that are licensed and knowledgeable in the intricacies of immunology and with the technologic and scientific foundation to support changing timelines and strategies inherent to vaccine development. The CRO often brings a more objective assessment for probability of success and may offer alternative development pathways. Vaccine developers are afforded more flexibility and are free to focus on innovation and internal core competencies. Functions readily outsourced to a competent partner include animal model development, safety and efficacy studies, immunotoxicity and immunogenicity, dose response studies, and stability and potency testing. These functions capitalize on the CRO partner's regulatory and scientific talent and expertise, and reduce infrastructure expenses for the vaccine developer. Successful partnerships result in development efficiencies, elimination or reduced redundancies, and improved time to market. Keys to success include honest communications, transparency, and flexibility.

  17. Modular Extended-Stay HyperGravity Facility Design Concept: An Artificial-Gravity Space-Settlement Ground Analogue

    NASA Technical Reports Server (NTRS)

    Dorais, Gregory A.

    2015-01-01

    This document defines the design concept for a ground-based, extended-stay hypergravity facility as a precursor for space-based artificial-gravity facilities that extend the permanent presence of both human and non-human life beyond Earth in artificial-gravity settlements. Since the Earth's current human population is stressing the environment and the resources off-Earth are relatively unlimited, by as soon as 2040 more than one thousand people could be living in Earthorbiting artificial-gravity habitats. Eventually, the majority of humanity may live in artificialgravity habitats throughout this solar system as well as others, but little is known about the longterm (multi-generational) effects of artificial-gravity habitats on people, animals, and plants. In order to extend life permanently beyond Earth, it would be useful to create an orbiting space facility that generates 1g as well as other gravity levels to rigorously address the numerous challenges of such an endeavor. Before doing so, developing a ground-based artificial-gravity facility is a reasonable next step. Just as the International Space Station is a microgravity research facility, at a small fraction of the cost and risk a ground-based artificial-gravity facility can begin to address a wide-variety of the artificial-gravity life-science questions and engineering challenges requiring long-term research to enable people, animals, and plants to live off-Earth indefinitely.

  18. Gender-based performance differences in an introductory physics course

    NASA Astrophysics Data System (ADS)

    McKinnon, Mark Lee

    Cognitive research has indicated that the difference between males and females is negligible. Paradoxically, in traditionally-taught college level introductory physics courses, males have outperformed females. UC Davis' Physics 7A (the first class of a three-quarter Introduction to Physics sequence for Life-Science students), however, counters this trend since females perform similarly to males. The gender-based performance difference within the other two quarters (Physics 7B & 7C) of the radically restructured, active-learning physics sequence still echo the traditionally-taught courses. In one experiment, I modified the laboratory activity instructions of the Physics 7C course to encourage further group interaction. These modifications did not affect the gender-based performance difference. In a later experiment, I compared students' performance on different forms of assessment for certain physics concepts during the Physics 7C course. Over 500 students took weekly quizzes at different times. The students were given different quiz questions on the same topics. Several quiz questions seemed to favor males while others were more gender equitable. I highlighted comparisons between a few pairs of questions that assessed students' understanding of the same physical concept. Males tended to perform better in responding to questions that seemed to require spatial visualization. Questions that required greater understanding of the physical concept or scientific model were more gender neutral.

  19. Acoustic force mapping in a hybrid acoustic-optical micromanipulation device supporting high resolution optical imaging† †Electronic supplementary information (ESI) available: Additional information about 1D model calculations for a piezoelectric transducer. See DOI: 10.1039/c6lc00182c Click here for additional data file.

    PubMed Central

    McDougall, Craig; MacDonald, Michael Peter; Ritsch-Marte, Monika

    2016-01-01

    Many applications in the life-sciences demand non-contact manipulation tools for forceful but nevertheless delicate handling of various types of sample. Moreover, the system should support high-resolution optical imaging. Here we present a hybrid acoustic/optical manipulation system which utilizes a transparent transducer, making it compatible with high-NA imaging in a microfluidic environment. The powerful acoustic trapping within a layered resonator, which is suitable for highly parallel particle handling, is complemented by the flexibility and selectivity of holographic optical tweezers, with the specimens being under high quality optical monitoring at all times. The dual acoustic/optical nature of the system lends itself to optically measure the exact acoustic force map, by means of direct force measurements on an optically trapped particle. For applications with (ultra-)high demand on the precision of the force measurements, the position of the objective used for the high-NA imaging may have significant influence on the acoustic force map in the probe chamber. We have characterized this influence experimentally and the findings were confirmed by model simulations. We show that it is possible to design the chamber and to choose the operating point in such a way as to avoid perturbations due to the objective lens. Moreover, we found that measuring the electrical impedance of the transducer provides an easy indicator for the acoustic resonances. PMID:27025398

  20. Batch fabrication of polymer microfluidic cartridges for QCM sensor packaging by direct bonding

    NASA Astrophysics Data System (ADS)

    Sandström, Niklas; Zandi Shafagh, Reza; Gylfason, Kristinn B.; Haraldsson, Tommy; van der Wijngaart, Wouter

    2017-12-01

    Quartz crystal microbalance (QCM) sensing is an established technique commonly used in laboratory based life-science applications. However, the relatively complex, multi-part design and multi-step fabrication and assembly of state-of-the-art QCM cartridges make them unsuited for disposable applications such as point-of-care (PoC) diagnostics. In this work, we present the uncomplicated manufacturing of QCMs in polymer microfluidic cartridges. Our novel approach comprises two key innovations: the batch reaction injection molding of microfluidic parts; and the integration of the cartridge components by direct, unassisted bonding. We demonstrate molding of batches of 12 off-stoichiometry thiol-ene epoxy polymer (OSTE+) polymer parts in a single molding cycle using an adapted reaction injection molding process; and the direct bonding of the OSTE+  parts to other OSTE+  substrates, to printed circuit boards, and to QCMs. The microfluidic QCM OSTE+  cartridges were successfully evaluated in terms of liquid sealing as well as electrical properties, and the sensor performance characteristics are on par with those of a commercially available QCM biosensor cartridge. The simplified manufacturing of QCM sensors with maintained performance potentializes novel application areas, e.g. as disposable devices in a point of care setting. Moreover, our results can be extended to simplifying the fabrication of other microfluidic devices with multiple heterogeneously integrated components.

  1. Diamagnetic levitation causes changes in the morphology, cytoskeleton, and focal adhesion proteins expression in osteocytes.

    PubMed

    Qian, A R; Wang, L; Gao, X; Zhang, W; Hu, L F; Han, J; Li, J B; Di, S M; Shang, Peng

    2012-01-01

    Diamagnetic levitation technology is a novel simulated weightless technique and has recently been applied in life-science research. We have developed a superconducting magnet platform with large gradient high magnetic field (LG-HMF), which can provide three apparent gravity levels, namely, μg (diamagnetic levitation), 1g, and 2g for diamagnetic materials. In this study, the effects of LG-HMF on the activity, morphology, and cytoskeleton (actin filament, microtubules, and vimentin intermediate filaments) in osteocyte - like cell line MLO-Y4 were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods, hematoxylin-eosin (HE) staining, and laser scanning confocal microscopy (LSCM), respectively. The changes induced by LG-HMF in distribution and expression of focal adhesion (FA) proteins, including vinculin, paxillin, and talin in MLO-Y4 were determined by LSCM and Western blotting. The results showed that LG-HMF produced by superconducting magnet had no lethal effects on MLO-Y4. Compared to control, diamagnetic levitation (μg) affected MLO-Y4 morphology, nucleus size, cytoskeleton architecture, and FA proteins distribution and expression. The study indicates that osteocytes are sensitive to altered gravity and FA proteins (vinculin, paxillin, and talin) may be involved in osteocyte mechanosensation. The diamagnetic levitation may be a novel ground-based space-gravity simulator and can be used for biological experiment at cellular level. © 2011 IEEE

  2. European Materials Research Society Spring Meeting, E-MRS 󈨦 Scientific/Technical Symposia and Exhibition, Held in Congress Center - Palais de la Musique et des Congres - Strasbourg, France on June 16-19, 1998.

    DTIC Science & Technology

    1998-06-01

    MICROPROCES- SING, H.-J. Kahlert and B. Burghardt, MicroLas Lasersystem GmbH, Robert- Bosch - Breite 10, 37079 Göttingen, Germany G-V2 14-30-14:45...Inst.f Phys. Chem., Univ. Göttingen, Tammannstr. 6, 37077 Göttingen, Germany, * present address: MicroLas Lasersystem GmbH, Robert- Bosch -Breite 10...SYNTHESIS OF CN-BCN LAYERS ON DIAMOND FILMS IN BORAZINE AND AMMONIA , M. Ugarov, V. Ageev. A. Karabutov, E. Loubnin, S. Pimenov, V. Konov, Natural

  3. Recent developments of advanced structures for space optics at Astrium, Germany

    NASA Astrophysics Data System (ADS)

    Stute, Thomas; Wulz, Georg; Scheulen, Dietmar

    2003-12-01

    The mechanical division of EADS Astrium GmbH, Friedrichshafen Germany, the former Dornier Satellitensystem GmbH is currently engaged with the development, manufacturing and testing of three different advanced dimensionally stable composite and ceramic material structures for satellite borne optics: -CFRP Camera Structure -Planck Telescope Reflectors -NIRSpec Optical Bench Breadboard for James Web Space Telescope The paper gives an overview over the requirements and the main structural features how these requirements are met. Special production aspects and available test results are reported.

  4. Scientists as Producers, Presenters, Videographers, Distributors and 'Stars': The Revolution In Science Filmmaking, from COSMOS to iPhones on Kilimanjaro

    NASA Astrophysics Data System (ADS)

    Haines-Stiles, G.; Akuginow, E.; Morris, K.

    2013-12-01

    In 1980, Carl Sagan's COSMOS received ratings of some 16 million and won three Emmys and a Peabody award. Sagan was hailed as a 'Showman of Science' by Time magazine, confirming his status as a science superstar. Haines-Stiles, 1st author for this presentation, was a Senior Producer and series director on what was for several decades PBS's highest-rated science series. Some researchers still consider primetime series on national networks as THE way to engage and inform audiences. But a revolution in both the making and consuming of science film and television has transformed the media landscape from high profile series such as COSMOS to more of a 'horizontal' ecosystem in which different formats for diverse audiences via multiple distribution networks are the norm. From the early 1990's the Internet has played an increasingly prominent role in this revolution. In 1993, Haines-Stiles and Akuginow added interactivity to traditional one-way TV broadcasts with 'Dale's Dive Diary,' in what was arguably the world's first science blog, detailing online the joys and rigors of working in Antarctica. Increasingly, the evolution of media allowed for the documentation of the process of doing science along with "eureka" discoveries and press conference results. In POLAR-PALOOZA (PPZA) this new perspective was further extended by taking Arctic and Antarctic researchers on the road to science museums in some 25 communities across the USA for spoken-word performances supported by High Definition video profiles of scientists at work at remote locations. In one instance, a researcher was given a crash course in videography and loaned a low-cost prosumer camcorder to take with her to the heart of East Antarctica. Excellent video was captured, and made part of large screen presentations in IMAX-scale theaters. In addition to the Summative Evaluation (required by project sponsors, NSF and NASA) which focused on audience responses, a recent research paper by communications scholar, Kim

  5. 77 FR 67675 - Importer of Controlled Substances, Notice of Registration, SA INTL GMBH C/O., Sigma Aldrich Co...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... (2315) II Glutethimide (2550) II Nabilone (7379) II Phencyclidine (7471) II Cocaine (9041) II Codeine... international treaties, conventions, or protocols in effect on May 1, 1971, at this time. DEA has investigated...

  6. 75 FR 27487 - Airworthiness Directives; Bombardier-Rotax GmbH 912 F Series and 912 S Series Reciprocating Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... Gunskirchen, Austria, or go to: http://www.rotax-aircraft-engines.com/ , for the service information... Proposed AD This product has been approved by the aviation authority of Austria, and is approved for operation in the United States. Pursuant to our bilateral agreement with Austria, they have notified us of...

  7. Veneered zirconia inlay-retained fixed dental prostheses: 10-Year results from a prospective clinical study.

    PubMed

    Rathmann, Friederike; Bömicke, Wolfgang; Rammelsberg, Peter; Ohlmann, Brigitte

    2017-09-01

    The purpose of this study was to evaluate the 10-year clinical performance of zirconia-based inlay-retained fixed dental prostheses (IRFDP). For replacement of a molar in 27 patients, 30 IRFDP were luted by use of different cements, Panavia F (Kuraray Europe GmbH) or Multilink Automix (Ivoclar Vivadent GmbH), with use of inlay/inlay, inlay/full-crown, or inlay/partial-crown retainers for anchorage. Frameworks were milled from yttria-stabilized zirconia (IPS e.maxZirCAD; Ivoclar Vivadent GmbH) and fully veneered with pressable ceramic (IPS e.max ZirPress; Ivoclar Vivadent GmbH). Before luting, the IRFDP were silica-coated (Rocatec; 3M Espe) and silanized (Monobond S; Ivoclar Vivadent GmbH). Complications (for example, chipping or delamination of the veneering ceramic, debonding, secondary caries, endodontic treatment, and abutment tooth fracture) and failure were reported, by use of standardized report forms, 2 weeks, 6 months, and 1, 2, and 10 years after cementation. Statistical analysis included Kaplan-Meier survival and success (complication-free survival) and Cox regression analysis (α=0.05 for all). During the 10-year observation period, the complications most often observed were chipping of the veneer and debonding. Twenty-five restorations failed and one participant dropped out. Cumulative 10-year survival and success were 12.1% and 0%, respectively. The design of the retainer, use of a dental dam, choice of cement, and location in the dental arch had no statistically significant effect on the occurrence of complications. Use of fully veneered zirconia-based IRFDP with this technique cannot be recommended. A large incidence of complications and poor survival were observed for fully veneered zirconia-based IRFDP, revealing an urgent need for further design improvements for this type of restoration. This, again, emphasizes the need for testing of new restoration designs in clinical trials before implementation in general dental practice. Copyright © 2017

  8. Identifying On-Orbit Test Targets for Space Fence Operational Testing

    NASA Astrophysics Data System (ADS)

    Pechkis, D.; Pacheco, N.; Botting, T.

    2014-09-01

    Space Fence will be an integrated system of two ground-based, S-band (2 to 4 GHz) phased-array radars located in Kwajalein and perhaps Western Australia [1]. Space Fence will cooperate with other Space Surveillance Network sensors to provide space object tracking and radar characterization data to support U.S. Strategic Command space object catalog maintenance and other space situational awareness needs. We present a rigorous statistical test design intended to test Space Fence to the letter of the program requirements as well as to characterize the system performance across the entire operational envelope. The design uses altitude, size, and inclination as independent factors in statistical tests of dependent variables (e.g., observation accuracy) linked to requirements. The analysis derives the type and number of necessary test targets. Comparing the resulting sample sizes with the number of currently known targets, we identify those areas where modelling and simulation methods are needed. Assuming hypothetical Kwajalein radar coverage and a conservative number of radar passes per object per day, we conclude that tests involving real-world space objects should take no more than 25 days to evaluate all operational requirements; almost 60 percent of the requirements can be tested in a single day and nearly 90 percent can be tested in one week or less. Reference: [1] L. Haines and P. Phu, Space Fence PDR Concept Development Phase, 2011 AMOS Conference Technical Papers.

  9. An analytic study of nonsteady two-phase laminar boundary layer around an airfoil

    NASA Technical Reports Server (NTRS)

    Hsu, Yu-Kao

    1989-01-01

    Recently, NASA, FAA, and other organizations have focused their attention upon the possible effects of rain on airfoil performance. Rhode carried out early experiments and concluded that the rain impacting the aircraft increased the drag. Bergrum made numerical calculation for the rain effects on airfoils. Luers and Haines did an analytic investigation and found that heavy rain induces severe aerodynamic penalties including both a momentum penalty due to the impact of the rain and a drag and lift penalty due to rain roughening of the airfoil and fuselage. More recently, Hansman and Barsotti performed experiments and declared that performance degradation of an airfoil in heavy rain is due to the effective roughening of the surface by the water layer. Hansman and Craig did further experimental research at low Reynolds number. E. Dunham made a critical review for the potential influence of rain on airfoil performance. Dunham et al. carried out experiments for the transport type airfoil and concluded that there is a reduction of maximum lift capability with increase in drag. There is a scarcity of published literature in analytic research of two-phase boundary layer around an airfoil. Analytic research is being improved. The following assumptions are made: the fluid flow is non-steady, viscous, and incompressible; the airfoil is represented by a two-dimensional flat plate; and there is only a laminar boundary layer throughout the flow region. The boundary layer approximation is solved and discussed.

  10. Metabolomics for undergraduates: Identification and pathway assignment of mitochondrial metabolites.

    PubMed

    Marques, Ana Patrícia; Serralheiro, Maria Luisa; Ferreira, António E N; Freire, Ana Ponces; Cordeiro, Carlos; Silva, Marta Sousa

    2016-01-01

    Metabolomics is a key discipline in systems biology, together with genomics, transcriptomics, and proteomics. In this omics cascade, the metabolome represents the biochemical products that arise from cellular processes and is often regarded as the final response of a biological system to environmental or genetic changes. The overall screening approach to identify all the metabolites in a given biological system is called metabolic fingerprinting. Using high-resolution and high-mass accuracy mass spectrometry, large metabolome coverage, sensitivity, and specificity can be attained. Although the theoretical concepts of this methodology are usually provided in life-science programs, hands-on laboratory experiments are not usually accessible to undergraduate students. Even if the instruments are available, there are not simple laboratory protocols created specifically for teaching metabolomics. We designed a straightforward hands-on laboratory experiment to introduce students to this methodology, relating it to biochemical knowledge through metabolic pathway mapping of the identified metabolites. This study focuses on mitochondrial metabolomics since mitochondria have a well-known, medium-sized cellular sub-metabolome. These features facilitate both data processing and pathway mapping. In this experiment, students isolate mitochondria from potatoes, extract the metabolites, and analyze them by high-resolution mass spectrometry (using an FT-ICR mass spectrometer). The resulting mass list is submitted to an online program for metabolite identification, and compounds associated with mitochondrial pathways can be highlighted in a metabolic network map. © 2015 The International Union of Biochemistry and Molecular Biology.

  11. BioJazz: in silico evolution of cellular networks with unbounded complexity using rule-based modeling.

    PubMed

    Feng, Song; Ollivier, Julien F; Swain, Peter S; Soyer, Orkun S

    2015-10-30

    Systems biologists aim to decipher the structure and dynamics of signaling and regulatory networks underpinning cellular responses; synthetic biologists can use this insight to alter existing networks or engineer de novo ones. Both tasks will benefit from an understanding of which structural and dynamic features of networks can emerge from evolutionary processes, through which intermediary steps these arise, and whether they embody general design principles. As natural evolution at the level of network dynamics is difficult to study, in silico evolution of network models can provide important insights. However, current tools used for in silico evolution of network dynamics are limited to ad hoc computer simulations and models. Here we introduce BioJazz, an extendable, user-friendly tool for simulating the evolution of dynamic biochemical networks. Unlike previous tools for in silico evolution, BioJazz allows for the evolution of cellular networks with unbounded complexity by combining rule-based modeling with an encoding of networks that is akin to a genome. We show that BioJazz can be used to implement biologically realistic selective pressures and allows exploration of the space of network architectures and dynamics that implement prescribed physiological functions. BioJazz is provided as an open-source tool to facilitate its further development and use. Source code and user manuals are available at: http://oss-lab.github.io/biojazz and http://osslab.lifesci.warwick.ac.uk/BioJazz.aspx. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Space Radiation Dosimetry to Evaluate the Effect of Polyethylene Shielding in the Russian Segment of the International Space Station

    NASA Astrophysics Data System (ADS)

    Nagamatsu, Aiko; Casolino, Marco; Larsson, Oscar; Ito, Tsuyoshi; Yasuda, Nakahiro; Kitajo, Keiichi; Shimada, Ken; Takeda, Kazuo; Tsuda, Shuichi; Sato, Tatsuhiko

    As a part of the Alteino Long Term Cosmic Ray measurements on board the International Space Station (ALTCRISS) project, the shielding effect of polyethylene (PE) were evaluated in the Russian segment of the ISS, using active and passive dosimeter systems covered with or without PE shielding. For the passive dosimeter system, PADLES (Passive Dosimeter for Life-Science and Experiments in Space) was used in the project, which consists of a Thermo-Luminescent Dosimeters (TLD) and CR-39 Plastic Nuclear Track Detectors (PNTDs) attached to a radiator. Not only CR-39 PNTD itself but also a tissue equivalent material, NAN-JAERI, were employed as the radiator in order to investigate whether CR-39 PNTD can be used as a surrogate of tissue equivalent material in space dosimetry or not. The agreements between the doses measured by PADLES with CR-39 PNTD and NAN-JAERI radiators were quite satisfactorily, indicating the tissue-equivalent dose can be measured by conventional PADLES even though CR-39 PNTD is not perfect tissue-equivalent material. It was found that the shielding effect of PE varies with location inside the spacecraft: it became less significant with an increase of the mean thickness of the wall. This tendency was also verified by Monte Carlo simulation using the PHITS code. Throughout the flight experiments, in a series of four phases in the ALTCRISS project from December 2005 to October 2007, we assessed the ability of PE to decrease radiation doses in Low Earth Orbit(LEO).

  13. e!DAL--a framework to store, share and publish research data.

    PubMed

    Arend, Daniel; Lange, Matthias; Chen, Jinbo; Colmsee, Christian; Flemming, Steffen; Hecht, Denny; Scholz, Uwe

    2014-06-24

    The life-science community faces a major challenge in handling "big data", highlighting the need for high quality infrastructures capable of sharing and publishing research data. Data preservation, analysis, and publication are the three pillars in the "big data life cycle". The infrastructures currently available for managing and publishing data are often designed to meet domain-specific or project-specific requirements, resulting in the repeated development of proprietary solutions and lower quality data publication and preservation overall. e!DAL is a lightweight software framework for publishing and sharing research data. Its main features are version tracking, metadata management, information retrieval, registration of persistent identifiers (DOI), an embedded HTTP(S) server for public data access, access as a network file system, and a scalable storage backend. e!DAL is available as an API for local non-shared storage and as a remote API featuring distributed applications. It can be deployed "out-of-the-box" as an on-site repository. e!DAL was developed based on experiences coming from decades of research data management at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK). Initially developed as a data publication and documentation infrastructure for the IPK's role as a data center in the DataCite consortium, e!DAL has grown towards being a general data archiving and publication infrastructure. The e!DAL software has been deployed into the Maven Central Repository. Documentation and Software are also available at: http://edal.ipk-gatersleben.de.

  14. Shrinking microbubbles with microfluidics: mathematical modelling to control microbubble sizes.

    PubMed

    Salari, A; Gnyawali, V; Griffiths, I M; Karshafian, R; Kolios, M C; Tsai, S S H

    2017-11-29

    Microbubbles have applications in industry and life-sciences. In medicine, small encapsulated bubbles (<10 μm) are desirable because of their utility in drug/oxygen delivery, sonoporation, and ultrasound diagnostics. While there are various techniques for generating microbubbles, microfluidic methods are distinguished due to their precise control and ease-of-fabrication. Nevertheless, sub-10 μm diameter bubble generation using microfluidics remains challenging, and typically requires expensive equipment and cumbersome setups. Recently, our group reported a microfluidic platform that shrinks microbubbles to sub-10 μm diameters. The microfluidic platform utilizes a simple microbubble-generating flow-focusing geometry, integrated with a vacuum shrinkage system, to achieve microbubble sizes that are desirable in medicine, and pave the way to eventual clinical uptake of microfluidically generated microbubbles. A theoretical framework is now needed to relate the size of the microbubbles produced and the system's input parameters. In this manuscript, we characterize microbubbles made with various lipid concentrations flowing in solutions that have different interfacial tensions, and monitor the changes in bubble size along the microfluidic channel under various vacuum pressures. We use the physics governing the shrinkage mechanism to develop a mathematical model that predicts the resulting bubble sizes and elucidates the dominant parameters controlling bubble sizes. The model shows a good agreement with the experimental data, predicting the resulting microbubble sizes under different experimental input conditions. We anticipate that the model will find utility in enabling users of the microfluidic platform to engineer bubbles of specific sizes.

  15. Nanoscopium: a Scanning Hard X-ray Nanoprobe Beamline at Synchrotron Soleil

    NASA Astrophysics Data System (ADS)

    Somogyi, A.; Polack, F.; Moreno, T.

    2010-06-01

    Nanoscopium is the single scanning hard X-ray nano-probe beamline planned at SOLEIL. This ˜155 m long beamline will fully exploit the high brilliance and coherence characteristics of the X-ray beam both for diffraction limited focusing and for contrast formation. It will offer the most advanced imaging techniques in multimodal mode and will be a research tool for a wide user community working in the fields of earth-, environmental-, and life-sciences. The different μ-μnano-probe techniques offered by the beamline will permit elemental mapping at trace (ppm) levels (scanning XRF), speciation mapping (XANES), phase gradient mapping (scanning differential phase contrast), and density-contrast based imaging of internal structures (coherent diffraction imaging) in the 30 nm to 1 μm spatial resolution range, also in "in situ conditions". Nanoscopium will cover the 5-20 keV energy range. The stability of the nanobeam will be ensured by horizontally reflecting beamline optics (a sagitally and a tangentially pre-focusing mirror, horizontally reflecting monochromators) in front of the overfilled secondary source. Trade-off between high energy resolution (ΔE/E˜10-4) and high flux (1011 ph/s with ΔE/E˜10-2) will be achieved by two interchangeable monochromators (a double crystal and a double multilayer one). KB mirror and FZP lenses will be used as focusing devices. The beamline is in the design and construction phase. It is foreseen to be open for users at the beginning of 2013.

  16. The flaws in the detail of an observational study on transcatheter aortic valve implantation versus surgical aortic valve replacement in intermediate-risks patients.

    PubMed

    Barili, Fabio; Freemantle, Nick; Folliguet, Thierry; Muneretto, Claudio; De Bonis, Michele; Czerny, Martin; Obadia, Jean Francois; Al-Attar, Nawwar; Bonaros, Nikolaos; Kluin, Jolanda; Lorusso, Roberto; Punjabi, Prakash; Sadaba, Rafael; Suwalski, Piotr; Benedetto, Umberto; Böning, Andreas; Falk, Volkmar; Sousa-Uva, Miguel; Kappetein, Pieter A; Menicanti, Lorenzo

    2017-06-01

    The PARTNER group recently published a comparison between the latest generation SAPIEN 3 transcatheter aortic valve implantation (TAVI) system (Edwards Lifesciences, Irvine, CA, USA) and surgical aortic valve replacement (SAVR) in intermediate-risk patients, apparently demonstrating superiority of the TAVI and suggesting that TAVI might be the preferred treatment method in this risk class of patients. Nonetheless, assessment of the non-randomized methodology used in this comparison reveals challenges that should be addressed in order to elucidate the validity of the results. The study by Thourani and colleagues showed several major methodological concerns: suboptimal methods in propensity score analysis with evident misspecification of the propensity scores (PS; no adjustment for the most significantly different covariates: left ventricular ejection fraction, moderate-severe mitral regurgitation and associated procedures); use of PS quintiles rather than matching; inference on not-adjusted Kaplan-Meier curves, although the authors correctly claimed for the need of balancing score adjusting for confounding factors in order to have unbiased estimates of the treatment effect; evidence of poor fit; lack of data on valve-related death.These methodological flaws invalidate direct comparison between treatments and cannot support authors' conclusions that TAVI with SAPIEN 3 in intermediate-risk patients is superior to surgery and might be the preferred treatment alternative to surgery. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  17. Capacity building in safe nanotechnologies

    NASA Astrophysics Data System (ADS)

    Keller, Markus; Gommel, Udo

    2011-07-01

    In all places where engineered Nanoparticles (ENPs) are produced, used or handled, adequate workplace safety precautions should be implemented due to the protection of workers and the surrounding environment. Any possible accidental release of ENPs should be evaluated. Thereby detected potential risks have to be eliminated as far as possible. An implemented reasonable safety culture in each ENP-related company will help to meet this challenge. Different infrastructures and workplace design can help to reduce the risk of an accidentally contact of the workers with ENPs: Transferable examples will be shown from the semiconductor and life-science Industry. These systems like clean rooms, glove boxes, fume cupboards, filter and suction systems and other restricted area barrier access systems (RABS) are mainly being developed to protect sensitive products, but they can also be used to protect working personnel. Clean environments regarding airborne particulate contaminations can be classified according to ISO 14644-1. A short insight into this ISO-classification will be given. But overall, a simple and reasonable workplace and workflow organization will reduce the risk of an accidental release of ENPs largely. This may lead to a therefore necessary adaption of existing workflow patterns. The workers have to get aware about the potential risks! This can be done with appropriate education materials, leaflets, posters and brochures. These are some of the later outcomes from the NanoDevice dissemination and handbook work package.

  18. 75 FR 71371 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-01, TAE 125-02-99, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... permeability is not always recognized as fault by the FADEC. The MAP value measured by the sensor may be lower... channel B manifold air pressure (MAP) sensor hose permeability is not always recognized as fault by the... between the national Government and the States, or on the distribution of power and responsibilities among...

  19. 77 FR 57041 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-01, TAE 125-02-99, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... channel B manifold air pressure sensor hose permeability was not always recognized as a fault by the FADEC... States, on the relationship between the national Government and the States, or on the distribution of...

  20. 75 FR 32253 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02...

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    2010-06-08

    ... shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Facility, U.S. Department of Transportation, 1200 New Jersey Avenue, SE., West Building Ground Floor, Room...

  1. 76 FR 17757 - Airworthiness Directives; Thielert Aircraft Engines GmbH Models TAE 125-01, TAE 125-02-99, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ...: Service experience has shown that a case of FADEC channel B manifold air pressure (MAP) sensor hose... combustion chamber and thus the available power of the engine. A change in FADEC software version 2.91 will..., previous software versions allow--under certain conditions and on DA 42 aircraft only--the initiation of a...

  2. 75 FR 53846 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... Engines Installed In, But Not Limited To, Diamond Aircraft Industries Model DA 42 Airplanes; Correction..., Diamond Aircraft Industries model DA 42 airplanes. The part number for engine model TAE 125-01 is missing...-99 reciprocating engines, installed in, but not limited to, Diamond Aircraft Industries model DA 42...

  3. 75 FR 7996 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... showed that it was mainly the result of failure of the Proportional Pressure Reducing Valve (PPRV) (also... identified as the primary source of vibrations for the PPRV, and it has also been determined that failure of... TAE 125 engines. The investigations showed that it was mainly the result of failure of the PPRV due to...

  4. 75 FR 12439 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-02-99 and TAE 125...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... has amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance Manual OM-02-02... a new rail pressure control valve P/N 05-7320-E000702 and 02-7320-04100R3 and has amended the ALS of...-7320- 04100R3 and has amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance...

  5. 76 FR 64285 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-02-99 and TAE 125...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance Manual OM-02-02 to... shutdowns of the engine(s). TAE has also amended the ALS of the Operation & Maintenance Manual OM- 02-01 to...-E000702 and has amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance Manual...

  6. Retracted: Bacteria diversity overview and endoglucanase assessment from Himalayan Tapovan geothermal spring.

    PubMed

    Sahoo, Jitendra Kumar; Navani, Naveen Kumar; Pathania, Ranjana

    2015-08-25

    The above article from the Journal of Basic Microbiology, published online on 25 August 2015 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/doi/10.1002/jobm.201500135/pdf), has been retracted by agreement between Naveen Kumar Navani and Ranjana Pathania, the Editor-in-Chief and Wiley-VCH GmbH & Co. KGaA. The retraction has been agreed because the article has been submitted and approved for publication by Jitendra Kumar Sahoo without consent in any form by the named co-authors Naveen Kumar Navani and Ranjana Pathania. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Mountain Permafrost in the Yukon Territory, Canada: Mapping and Modelling

    NASA Astrophysics Data System (ADS)

    Lewkowicz, A. G.; Bonnaventure, P.; Schultz, E.; Etzelmuller, B.

    2006-12-01

    The distribution and characteristics of mountain permafrost in North America are poorly known compared to lowland permafrost, and predictions of climatic change impacts are therefore subject to a higher degree of uncertainty. Recent DC resistivity soundings in association with borehole temperature information in the Yukon Territory, show the wide range of permafrost conditions that can exist at sites separated by short distances. To provide baseline information for future modelling, efforts are underway to produce a detailed map of permafrost probability in the mountains of the southern half of the Yukon Territory (60-65°N), an area greater than 200 x 103km2. The methodology is based on the Basal Temperature of Snow (BTS) technique, first developed in the European Alps. Ground surface temperatures measured at the base of snow > 80 cm thick in late winter are an indicator of permafrost presence or absence. We have used this method successfully in three study areas of about 200 km2: first, Wolf Creek basin near Whitehorse (Lewkowicz and Ednie, 2004) and now the western side of the Ruby Range adjacent to Kluane Lake, and the Haines Summit area in northwestern British Columbia. In each area, (1) we installed miniature temperature loggers at the ground surface and in the air to check on the timing of the BTS measurements; (2) we measured BTS values in the elevation zone across which permafrost was expected to become widespread; (3) we modelled the BTS spatial field using elevation (from a 30 m DEM) and potential incoming solar radiation (PISR) as the independent variables; and (4) we used logistic regression to compare the modelled BTS values with pit observations made in late-summer of the presence or absence of frozen ground. Both elevation and PISR were significant in the Wolf Creek and Ruby Range sites which have relatively continental climates and fall within the Upper Yukon-Stikine Basin climatic region (Wahl et al., 1987). For the Haines Summit area, however

  8. Small- Geo Solar Array: New Generation Of Solar Arrays For Commercial Telecom Satellites For Power Ranges Between 2,5 KW And 7,5 KW

    NASA Astrophysics Data System (ADS)

    Paarmann, Carola; Muller, Jens; Mende, Thomas; Borner, Carsten; Mascher, Rolf

    2011-10-01

    In the frame of the ESA supported Artes 11 program a new generation of GEO telecommunication satellites is under development. This platform will cover the power range from 2 to 5 kW. ASTRIUM GmbH is contracted to develop and design the Solar Array for this platform. Furthermore the manufacturing and the qualification of a PFM wing for the first flight model is foreseen. The satellite platform, called Small-GEO, is developed under the responsibility of OHB System. This first Small-GEO satellite is designated to be delivered to HISPASAT for operation. The concept of ASTRIUM GmbH is to use all the experiences from the very successful EUROSTAR 2000+, EUROSTAR-3000 and the ALPHABUS platform and to adapt the technologies to the Small- GEO Solar Array. With the benefit of the huge in-orbit heritage of these programs, the remaining risks for the Small-GEO Solar Array can be minimized. The development of the Small-GEO Solar Array extends the ASTRIUM GmbH product portfolio by covering now the complete power range between 2 kW and 31 kW. This paper provides an overview of the different configurations, their main design features and parameters.

  9. Sentinel 2 MMFU: The first European Mass Memory System Based on NAND-Flash Storage Technology

    NASA Astrophysics Data System (ADS)

    Staehle, M.; Cassel, M.; Lonsdorfer, U.; Gliem, F.; Walter, D.; Fichna, T.

    2011-08-01

    Sentinel-2 is the multispectral optical mission of the EU-ESA GMES (Global Monitoring for Environment and Security) program, currently under development by Astrium-GmbH in Friedrichshafen (Germany) for a launch in 2013. The mission features a 490 Mbit/s optical sensor operating at high duty cycles, requiring in turn a large 2.4 Tbit on-board storage capacity.The required storage capacity motivated the selection of the NAND-Flash technology which was already secured by a lengthy period (2004-2009) of detailed testing, analysis and qualification by Astrium GmbH, IDA and ESTEC. The mass memory system is currently being realized by Astrium GmbH.

  10. Adiabatic burst evaporation from bicontinuous nanoporous membranes

    PubMed Central

    Ichilmann, Sachar; Rücker, Kerstin; Haase, Markus; Enke, Dirk

    2015-01-01

    Evaporation of volatile liquids from nanoporous media with bicontinuous morphology and pore diameters of a few 10 nm is an ubiquitous process. For example, such drying processes occur during syntheses of nanoporous materials by sol–gel chemistry or by spinodal decomposition in the presence of solvents as well as during solution impregnation of nanoporous hosts with functional guests. It is commonly assumed that drying is endothermic and driven by non-equilibrium partial pressures of the evaporating species in the gas phase. We show that nearly half of the liquid evaporates in an adiabatic mode involving burst-like liquid-to-gas conversions. During single adiabatic burst evaporation events liquid volumes of up to 107 μm3 are converted to gas. The adiabatic liquid-to-gas conversions occur if air invasion fronts get unstable because of the built-up of high capillary pressures. Adiabatic evaporation bursts propagate avalanche-like through the nanopore systems until the air invasion fronts have reached new stable configurations. Adiabatic cavitation bursts thus compete with Haines jumps involving air invasion front relaxation by local liquid flow without enhanced mass transport out of the nanoporous medium and prevail if the mean pore diameter is in the range of a few 10 nm. The results reported here may help optimize membrane preparation via solvent-based approaches, solution-loading of nanopore systems with guest materials as well as routine use of nanoporous membranes with bicontinuous morphology and may contribute to better understanding of adsorption/desorption processes in nanoporous media. PMID:25926406

  11. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis

    PubMed Central

    Cudahy, Patrick G.T; Schumacher, Samuel G.; Steingart, Karen R.; Pai, Madhukar; Denkinger, Claudia M.

    2017-01-01

    Only 25% of multidrug-resistant tuberculosis (MDR-TB) cases are currently diagnosed. Line probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and isoniazid (INH) resistance and Mycobacterium tuberculosis detection. Genotype MTBDRplusV1 was WHO-endorsed in 2008 but newer LPAs have since been developed. This systematic review evaluated three LPAs: Hain Genotype MTBDRplusV1, MTBDRplusV2 and Nipro NTM+MDRTB. Study quality was assessed with QUADAS-2. Bivariate random-effects meta-analyses were performed for direct and indirect testing. Results for RIF and INH resistance were compared to phenotypic and composite (incorporating sequencing) reference standards. M. tuberculosis detection results were compared to culture. 74 unique studies were included. For RIF resistance (21 225 samples), pooled sensitivity and specificity (with 95% confidence intervals) were 96.7% (95.6–97.5%) and 98.8% (98.2–99.2%). For INH resistance (20 954 samples), pooled sensitivity and specificity were 90.2% (88.2–91.9%) and 99.2% (98.7–99.5%). Results were similar for direct and indirect testing and across LPAs. Using a composite reference standard, specificity increased marginally. For M. tuberculosis detection (3451 samples), pooled sensitivity was 94% (89.4–99.4%) for smear-positive specimens and 44% (20.2–71.7%) for smear-negative specimens. In patients with pulmonary TB, LPAs have high sensitivity and specificity for RIF resistance and high specificity and good sensitivity for INH resistance. This meta-analysis provides evidence for policy and practice. PMID:28100546

  12. [Estimation of N loss loading by runoff from paddy field during submersed period in Hangjiahu area].

    PubMed

    Tian, Ping; Chen, Yingxu; Tian, Guangming; Liang, Xinqiang; Zhang, Qiuling; Yu, Qiaogang; Li, Hua

    2006-10-01

    As the largest bread basket in Zhejiang Province, Hangjiahu area is facing more and more serious water pollution, while the N loss loading by runoff from the paddy field during its submersed period is the main cause of the pollution. Through field experiment and fixed spot observation, the model of precipitation - runoff in Yangtze delta was testified, and the results showed that the precipitation - runoff model from HE Baogen was basically accorded with the fact after considering the impact of field overflow mouth, and the error was between - 19. 9% and + 18. 0%. The model of N concentration with precipitation - runoff in paddy field during submersed period was brought forward, with the R value being 0. 948. These two models consisted of the model of N loss loading by runoff from paddy field during submersed period. Based on this model as well as the past 30 years data of fertilization and precipitation, 1: 250,000 topography map, land use map, and water system map, the N loss loading and its distribution were estimated by using GIS method, and the results showed that the N loss loading was different from place to place, with an average of 35.26 kg N x hm(-2), and accounting for 12. 69% of the applied N. The N loss loading in Anji and Yuhang with obviously more precipitation was higher than that in other places, while Haining also had a serious N loss problem because of the huge amount of applied N.

  13. 76 FR 43346 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Open Mobile...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ..., Dubendorf, Switzerland; Eurofins Product Service GmbH, Reichenwalde, Germany; Expway, Paris, France..., Inc., Nashua, NH; SEVEN, Helsinki, Finland; SFR, Paris, France; Sintesio, Foundation, Bled, SLOVENIA...

  14. 75 FR 23194 - Airworthiness Directives; GROB-WERKE GMBH & CO KG Models G102 ASTIR CS and G102 STANDARD ASTIR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... & CO KG Models G102 ASTIR CS and G102 STANDARD ASTIR III Gliders AGENCY: Federal Aviation.... Affected ADs (b) None. Applicability (c) This AD applies to Models G102 ASTIR CS and G102 STANDARD ASTIR..., Standards Office, FAA, has the authority to approve AMOCs for this AD, if requested using the procedures...

  15. 75 FR 47182 - Airworthiness Directives; GROB-WERKE GMBH & CO KG Models G102 ASTIR CS and G102 STANDARD ASTIR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... fuselage tail which could cause a displacement of the sailplane centre of gravity and consequently may lead... tanks could run down into the fuselage and fuselage tail which could cause a displacement of the... tanks could run down into the fuselage and fuselage tail which could cause a displacement of the...

  16. Comparison of three noninvasive methods for hemoglobin screening of blood donors.

    PubMed

    Ardin, Sergey; Störmer, Melanie; Radojska, Stela; Oustianskaia, Larissa; Hahn, Moritz; Gathof, Birgit S

    2015-02-01

    To prevent phlebotomy of anemic individuals and to ensure hemoglobin (Hb) content of the blood units, Hb screening of blood donors before donation is essential. Hb values are mostly evaluated by measurement of capillary blood obtained from fingerstick. Rapid noninvasive methods have recently become available and may be preferred by donors and staff. The aim of this study was to evaluate for the first time all different noninvasive methods for Hb screening. Blood donors were screened for Hb levels in three different trials using three different noninvasive methods (Haemospect [MBR Optical Systems GmbH & Co. KG], NBM 200 [LMB Technology GmbH], Pronto-7 [Masimo Europe Ltd]) in comparison to the established fingerstick method (CompoLab Hb [Fresenius Kabi GmbH]) and to levels obtained from venous samples on a cell counter (Sysmex [Sysmex Europe GmbH]) as reference. The usability of the noninvasive methods was assessed with an especially developed survey. Technical failures occurred by using the Pronto-7 due to nail polish, skin color, or ambient light. The NBM 200 also showed a high sensitivity to ambient light and noticeably lower Hb levels for women than obtained from the Sysmex. The statistical analysis showed the following bias and standard deviation of differences of all methods in comparison to the venous results: Haemospect, -0.22 ± 1.24; NBM, 200 -0.12 ± 1.14; Pronto-7, -0.50 ± 0.99; and CompoLab Hb, -0.53 ± 0.81. Noninvasive Hb tests represent an attractive alternative by eliminating pain and reducing risks of blood contamination. The main problem for generating reliable results seems to be preanalytical variability in sampling. Despite the sensitivity to environmental stress, all methods are suitable for Hb measurement. © 2014 AABB.

  17. Comparison of outcomes of tricuspid annuloplasty with 3D-rigid versus flexible prosthetic ring for functional tricuspid regurgitation secondary to rheumatic mitral valve disease.

    PubMed

    Wang, Haiping; Liu, Xiancheng; Wang, Xin; Lv, Zhenqian; Liu, Xiaojun; Xu, Ping

    2016-11-01

    Annuloplasty bands and rings are widely used for repairing functional tricuspid regurgitation (FTR). However, the question regarding which is the ideal annuloplasty device remains unclear. The aim of this study was to compare the efficacy and mid-term durability of tricuspid ring annuloplasty for FTR secondary to rheumatic mitral valve disease using flexible Cosgrove-Edwards band and the rigid Edwards MC3 ring (Edwards Lifesciences, LLC, Irvine, CA, USA). We retrospectively collected the clinical data of those who underwent mitral valve replacement (MVR) in concomitant with tricuspid ring annuloplasty from 2009 to 2013. The flexible band was used in 46 patients (flexible group), and the 3D rigid ring was used in 60 patients (rigid group). Echocardiographic evaluation of tricuspid function was performed preoperatively and postoperatively. The grade of TR was significantly improved compared to preoperative values in two groups. There was no significant difference regarding postoperative TR grade between the two groups at 1 week and 2-3 months but there was statistical significant difference at postoperative 6-12 months, and 2-3 years. During the follow up period, 25 of 46 patients (54.3%) in flexible group and 22 of 60 patients (30.3%) in rigid group developed recurrent TR. Freedom from recurrent TR in flexible group is significant lower than rigid group in each postoperative follow up period. These findings suggest that 3D rigid ring annuloplasty might be more effective for tricuspid ring annuloplasty in FTR in mid-term postoperative periods when compared to flexible band.

  18. Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits.

    PubMed

    Fujiwara, Shigeki; Kawakubo, Yoshifumi; Mori, Satoshi; Tachihara, Keiichi; Toyoguchi, Izumi; Yokoyama, Takeshi

    2015-12-01

    Pressure-transducer kits have frequency characteristics such as natural frequency and damping coefficient, which affect the monitoring accuracy. The aim of the present study was to investigate the effect of planecta ports and a damping device (ROSE™, Argon Medical Devices, TX, USA) on the frequency characteristics of pressure-transducer kits. The FloTrac sensor kit (Edwards Lifesciences, CA, USA) and the DTXplus transducer kit (Argon Medical Devices) were prepared with planecta ports, and their frequency characteristics were tested with or without ROSE™. The natural frequency and damping coefficient of each kit were obtained using frequency characteristics analysis software and evaluated by plotting them on the Gardner's chart. By inserting a planecta port, the natural frequency markedly decreased in both the FloTrac sensor kit (from 40 to 22 Hz) and the DTXplus transducer kit (from 35 to 22 Hz). In both kits with one planecta port, the damping coefficient markedly increased by insertion of ROSE™ from 0.2 to 0.5, optimising frequency characteristics. In both kits with two planecta ports, however, the natural frequency decreased from 22 to 12 Hz. The damping coefficient increased from 0.2 to 0.8 by insertion of ROSE™; however, optimisation was not achieved even by ROSE™ insertion. Planecta ports decrease the natural frequency of the kit. ROSE™ is useful to optimise the frequency characteristics in the kits without or with one planecta port. However, optimisation is difficult with two or more planecta ports, even with the ROSE™ device.

  19. Comparison of outcomes of tricuspid annuloplasty with 3D-rigid versus flexible prosthetic ring for functional tricuspid regurgitation secondary to rheumatic mitral valve disease

    PubMed Central

    Wang, Haiping; Wang, Xin; Lv, Zhenqian; Liu, Xiaojun

    2016-01-01

    Background Annuloplasty bands and rings are widely used for repairing functional tricuspid regurgitation (FTR). However, the question regarding which is the ideal annuloplasty device remains unclear. The aim of this study was to compare the efficacy and mid-term durability of tricuspid ring annuloplasty for FTR secondary to rheumatic mitral valve disease using flexible Cosgrove-Edwards band and the rigid Edwards MC3 ring (Edwards Lifesciences, LLC, Irvine, CA, USA). Methods We retrospectively collected the clinical data of those who underwent mitral valve replacement (MVR) in concomitant with tricuspid ring annuloplasty from 2009 to 2013. The flexible band was used in 46 patients (flexible group), and the 3D rigid ring was used in 60 patients (rigid group). Echocardiographic evaluation of tricuspid function was performed preoperatively and postoperatively. Results The grade of TR was significantly improved compared to preoperative values in two groups. There was no significant difference regarding postoperative TR grade between the two groups at 1 week and 2–3 months but there was statistical significant difference at postoperative 6–12 months, and 2–3 years. During the follow up period, 25 of 46 patients (54.3%) in flexible group and 22 of 60 patients (30.3%) in rigid group developed recurrent TR. Freedom from recurrent TR in flexible group is significant lower than rigid group in each postoperative follow up period. Conclusions These findings suggest that 3D rigid ring annuloplasty might be more effective for tricuspid ring annuloplasty in FTR in mid-term postoperative periods when compared to flexible band. PMID:28066587

  20. Optical tomography by means of regularized MLEM

    NASA Astrophysics Data System (ADS)

    Majer, Charles L.; Urbanek, Tina; Peter, Jörg

    2015-09-01

    To solve the inverse problem involved in fluorescence mediated tomography a regularized maximum likelihood expectation maximization (MLEM) reconstruction strategy is proposed. This technique has recently been applied to reconstruct galaxy clusters in astronomy and is adopted here. The MLEM algorithm is implemented as Richardson-Lucy (RL) scheme and includes entropic regularization and a floating default prior. Hence, the strategy is very robust against measurement noise and also avoids converging into noise patterns. Normalized Gaussian filtering with fixed standard deviation is applied for the floating default kernel. The reconstruction strategy is investigated using the XFM-2 homogeneous mouse phantom (Caliper LifeSciences Inc., Hopkinton, MA) with known optical properties. Prior to optical imaging, X-ray CT tomographic data of the phantom were acquire to provide structural context. Phantom inclusions were fit with various fluorochrome inclusions (Cy5.5) for which optical data at 60 projections over 360 degree have been acquired, respectively. Fluorochrome excitation has been accomplished by scanning laser point illumination in transmission mode (laser opposite to camera). Following data acquisition, a 3D triangulated mesh is derived from the reconstructed CT data which is then matched with the various optical projection images through 2D linear interpolation, correlation and Fourier transformation in order to assess translational and rotational deviations between the optical and CT imaging systems. Preliminary results indicate that the proposed regularized MLEM algorithm, when driven with a constant initial condition, yields reconstructed images that tend to be smoother in comparison to classical MLEM without regularization. Once the floating default prior is included this bias was significantly reduced.

  1. Decline of clinical research in academic medical centers.

    PubMed

    Meador, Kimford J

    2015-09-29

    Marked changes in US medical school funding began in the 1960s with progressively increasing revenues from clinical services. The growth of clinical revenues slowed in the mid-1990s, creating a funding crisis for US academic health care centers, who responded by having their faculty increase their clinical duties at the expense of research activities. Surveys document the resultant stresses on the academic clinician researcher. The NIH provides greater funding for basic and translational research than for clinical research, and the new Patient-Centered Outcomes Research Institute is inadequately funded to address the scope of needed clinical research. An increasing portion of clinical research is funded by industry, which leaves many important clinical issues unaddressed. There is an inadequate supply of skilled clinical researchers and a lack of external support for clinical research. The impact on the academic environment in university medical centers is especially severe on young faculty, who have a shrinking potential to achieve successful academic careers. National health care research funding policies should encourage the right balance of life-science investigations. Medical universities need to improve and highlight education on clinical research for students, residents, fellows, and young faculty. Medical universities also need to provide appropriate incentives for clinical research. Without training to ensure an adequate supply of skilled clinical researchers and a method to adequately fund clinical research, discoveries from basic and translational research cannot be clinically tested and affect patient care. Thus, many clinical problems will continue to be evaluated and treated with inadequate or even absent evidence-based knowledge. © 2015 American Academy of Neurology.

  2. e!DAL - a framework to store, share and publish research data

    PubMed Central

    2014-01-01

    Background The life-science community faces a major challenge in handling “big data”, highlighting the need for high quality infrastructures capable of sharing and publishing research data. Data preservation, analysis, and publication are the three pillars in the “big data life cycle”. The infrastructures currently available for managing and publishing data are often designed to meet domain-specific or project-specific requirements, resulting in the repeated development of proprietary solutions and lower quality data publication and preservation overall. Results e!DAL is a lightweight software framework for publishing and sharing research data. Its main features are version tracking, metadata management, information retrieval, registration of persistent identifiers (DOI), an embedded HTTP(S) server for public data access, access as a network file system, and a scalable storage backend. e!DAL is available as an API for local non-shared storage and as a remote API featuring distributed applications. It can be deployed “out-of-the-box” as an on-site repository. Conclusions e!DAL was developed based on experiences coming from decades of research data management at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK). Initially developed as a data publication and documentation infrastructure for the IPK’s role as a data center in the DataCite consortium, e!DAL has grown towards being a general data archiving and publication infrastructure. The e!DAL software has been deployed into the Maven Central Repository. Documentation and Software are also available at: http://edal.ipk-gatersleben.de. PMID:24958009

  3. Goodbye genome paper, hello genome report: the increasing popularity of 'genome announcements' and their impact on science.

    PubMed

    Smith, David Roy

    2017-05-01

    Next-generation sequencing technologies have revolutionized genomics and altered the scientific publication landscape. Life-science journals abound with genome papers-peer-reviewed descriptions of newly sequenced chromosomes. Although they once filled the pages of Nature and Science, genome papers are now mostly relegated to journals with low-impact factors. Some have forecast the death of the genome paper and argued that they are using up valuable resources and not advancing science. However, the publication rate of genome papers is on the rise. This increase is largely because some journals have created a new category of manuscript called genome reports, which are short, fast-tracked papers describing a chromosome sequence(s), its GenBank accession number and little else. In 2015, for example, more than 2000 genome reports were published, and 2016 is poised to bring even more. Here, I highlight the growing popularity of genome reports and discuss their merits, drawbacks and impact on science and the academic publication infrastructure. Genome reports can be excellent assets for the research community, but they are also being used as quick and easy routes to a publication, and in some instances they are not peer reviewed. One of the best arguments for genome reports is that they are a citable, user-generated genomic resource providing essential methodological and biological information, which may not be present in the sequence database. But they are expensive and time-consuming avenues for achieving such a goal. © The Author 2016. Published by Oxford University Press.

  4. Transcatheter aortic valve implantation in patients with bicuspid aortic valve stenosis.

    PubMed

    Wijesinghe, Namal; Ye, Jian; Rodés-Cabau, Josep; Cheung, Anson; Velianou, James L; Natarajan, Madhu K; Dumont, Eric; Nietlispach, Fabian; Gurvitch, Ronen; Wood, David A; Tay, Edgar; Webb, John G

    2010-11-01

    We evaluated transcatheter aortic valve implantation (TAVI) in high-risk patients with bicuspid aortic valve (BAV) stenosis. TAVI shows promise in the treatment of severe stenosis of triscupid aortic valves, especially in high-risk patients. However, BAV stenosis has been considered a contraindication to TAVI. Eleven patients (age 52 to 90 years) with symptomatic severe BAV stenosis underwent TAVI at 3 Canadian tertiary hospitals between May 2006 and April 2010. All patients were considered high risk for surgical aortic valve replacement. Edwards-SAPIEN transcatheter heart valves (Edwards Lifesciences, Inc., Irvine, California) were used. Transfemoral or transapical access was selected, depending on the adequacy of femoral access. Access was transfemoral in 7 patients and transapical in 4 patients. There were no intraprocedural complications. Significant symptomatic and hemodynamic improvement was observed in 10 of 11 patients. Baseline aortic valve area of 0.65 ± 0.17 cm(2) and mean transaortic pressure gradient of 41 ± 22.4 mm Hg were improved to 1.45 ± 0.3 cm(2) and 13.4 ± 5.7 mm Hg, respectively. Two patients had moderate perivalvular leaks. At the 30-day follow-up there were 2 deaths due to multisystem failure in 2 transapical patients. In 1 patient an undersized, suboptimally positioned, unstable valve required late conversion to open surgery. TAVI in selected high-risk patients with severe BAV stenosis can be successfully performed with acceptable clinical outcomes but will require further evaluation. Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  5. "helix Nebula - the Science Cloud", a European Science Driven Cross-Domain Initiative Implemented in via AN Active Ppp Set-Up

    NASA Astrophysics Data System (ADS)

    Lengert, W.; Mondon, E.; Bégin, M. E.; Ferrer, M.; Vallois, F.; DelaMar, J.

    2015-12-01

    Helix Nebula, a European science cross-domain initiative building on an active PPP, is aiming to implement the concept of an open science commons[1] while using a cloud hybrid model[2] as the proposed implementation solution. This approach allows leveraging and merging of complementary data intensive Earth Science disciplines (e.g. instrumentation[3] and modeling), without introducing significant changes in the contributors' operational set-up. Considering the seamless integration with life-science (e.g. EMBL), scientific exploitation of meteorological, climate, and Earth Observation data and models open an enormous potential for new big data science. The work of Helix Nebula has shown that is it feasible to interoperate publicly funded infrastructures, such as EGI [5] and GEANT [6], with commercial cloud services. Such hybrid systems are in the interest of the existing users of publicly funded infrastructures and funding agencies because they will provide "freedom and choice" over the type of computing resources to be consumed and the manner in which they can be obtained. But to offer such freedom and choice across a spectrum of suppliers, various issues such as intellectual property, legal responsibility, service quality agreements and related issues need to be addressed. Finding solutions to these issues is one of the goals of the Helix Nebula initiative. [1] http://www.egi.eu/news-and-media/publications/OpenScienceCommons_v3.pdf [2] http://www.helix-nebula.eu/events/towards-the-european-open-science-cloud [3] e.g. https://sentinel.esa.int/web/sentinel/sentinel-data-access [5] http://www.egi.eu/ [6] http://www.geant.net/

  6. Decline of clinical research in academic medical centers

    PubMed Central

    2015-01-01

    Marked changes in US medical school funding began in the 1960s with progressively increasing revenues from clinical services. The growth of clinical revenues slowed in the mid-1990s, creating a funding crisis for US academic health care centers, who responded by having their faculty increase their clinical duties at the expense of research activities. Surveys document the resultant stresses on the academic clinician researcher. The NIH provides greater funding for basic and translational research than for clinical research, and the new Patient-Centered Outcomes Research Institute is inadequately funded to address the scope of needed clinical research. An increasing portion of clinical research is funded by industry, which leaves many important clinical issues unaddressed. There is an inadequate supply of skilled clinical researchers and a lack of external support for clinical research. The impact on the academic environment in university medical centers is especially severe on young faculty, who have a shrinking potential to achieve successful academic careers. National health care research funding policies should encourage the right balance of life-science investigations. Medical universities need to improve and highlight education on clinical research for students, residents, fellows, and young faculty. Medical universities also need to provide appropriate incentives for clinical research. Without training to ensure an adequate supply of skilled clinical researchers and a method to adequately fund clinical research, discoveries from basic and translational research cannot be clinically tested and affect patient care. Thus, many clinical problems will continue to be evaluated and treated with inadequate or even absent evidence-based knowledge. PMID:26156509

  7. Stress Analysis of Transcatheter Aortic Valve Leaflets Under Dynamic Loading: Effect of Reduced Tissue Thickness.

    PubMed

    Abbasi, Mostafa; Azadani, Ali N

    2017-07-01

    In order to accommodate transcatheter valves to miniaturized catheters, the leaflet thickness must be reduced to a value which is typically less than that of surgical bioprostheses. The study aim was to use finite-element simulations to determine the impact of the thickness reduction on stress and strain distribution. A 23 mm transcatheter aortic valve (TAV) was modelled based on the Edwards SAPIEN XT (Edwards Lifesciences, Irvine, CA, USA). Finite-element (FE) analysis was performed using the ABAQUS/Explicit solver. An ensemble-averaged transvalvular pressure waveform measured from in-vitro tests conducted in a pulse duplicator was applied to the leaflets. Through a parametric study, uniform TAV leaflet thickness was reduced from 0.5 to 0.18 mm. By reducing leaflet thickness, significantly higher stress values were found in the leaflet's fixed edge during systole, and in the commissures during diastole. Through dynamic FE simulations, the highest stress values were found during systole in the leaflet fixed edge. In contrast, at the peak of diastole high-stress regions were mainly observed in the commissures. The peak stress was increased by 178% and 507% within the leaflets after reducing the thickness of 0.5 mm to 0.18 mm at the peak of systole and diastole, respectively. The study results indicated that, the smaller the leaflet thickness, the higher the maximum principal stress. Increased mechanical stress on TAV leaflets may lead to accelerated tissue degeneration. By using a thinner leaflet, TAV durability may not atch with that of surgical bioprostheses.

  8. Five-Year Outcomes of the First Pivotal Clinical Trial of Balloon-Expandable Transcatheter Aortic Valve Replacement in Japan (PREVAIL JAPAN).

    PubMed

    Sawa, Yoshiki; Takayama, Morimasa; Goto, Tsuyoshi; Takanashi, Shuichiro; Komiya, Tatsuhiko; Tobaru, Tetsuya; Maeda, Koichi; Kuratani, Toru; Sakata, Yasushi

    2017-07-25

    Transcatheter aortic valve replacement (TAVR) has been an alternative less invasive therapy for high-surgical risk/inoperable patients with aortic valve stenosis (AS) in Japan. We report 5-year outcomes of the first pivotal clinical trial of TAVR in Japan (PREVAIL JAPAN).Methods and Results:A total of 64 patients with AS who were considered unsuitable candidates for surgery were enrolled at 3 centers in Japan (mean age: 84.3±6.1 years, female: 65.6%, STS score: 9.0±4.5%). Transfemoral approach (TF) and transapical approach (TA) was performed in 37 patients and 27 patients, respectively. At 5 years, freedom from all-cause death was 52.7% (TF: 51.3%, TA: 56.3%). Risk of all stroke at 5-year was 15.8% (TF: 8.9%, TA: 25.5%) and risk of major adverse cardiac and cerebrovascular events at 5 years was 58.0% (TF: 51.3%, TA: 69.2%). Mild or greater aortic regurgitation (AR) at 1 week was not associated with increased all-cause death at 5 years (69.1%) compared with none or trace AR (48.3%) (P=0.184). Patients with high STS score (>8) had higher mortality rate than those with low STS scores (≤8). The 5-year data from PREVAIL JAPAN show the clinical benefit of TAVR and suggest that balloon-expandable TAVR is an effective treatment option for Japanese patients with severe AS who are not suitable for surgery. (Funded by Edwards Lifesciences Limited; ClinicalTrials.gov number, NCT01113983.).

  9. Long-term results of aortic valve replacement with Edwards Prima Plus stentless bioprosthesis: eleven years' follow up.

    PubMed

    Auriemma, Stefano; D'Onofrio, Augusto; Brunelli, Massimo; Magagna, Paolo; Paccanaro, Mariemma; Rulfo, Fanny; Fabbri, Alessandro

    2006-09-01

    The Edwards Lifesciences Prima Plus stentless valve (ELSV) is a bioprosthesis manufactured from a porcine aortic root. The study aim was to evaluate late clinical outcomes after aortic valve replacement (AVR) with ELSV implanted as a miniroot in patients with aortic valve disease. Between 1993 and 2004, 318 patients (232 males, 86 females; mean age 69 +/- 9 years; range: 37-83 years) underwent AVR with the ELSV. Preoperatively, 102 patients (32%), 162 (51%) and 54 (17%) were in NYHA classes I/II, III and IV, respectively. Aortic stenosis, aortic regurgitation and combined lesions were present in 124 patients (39%), 114 (36%) and 41 (13%), respectively. Twenty patients (6%) were referred for an acute aortic dissection, 20 (6%) for an aortic root aneurysm, and 139 (44%) had an associated aneurysmal dilatation of the ascending aorta. The ascending aorta was replaced in 159 patients (50%); aortic arch replacement was required in 10 (3%). Coronary artery bypass graft was performed in 86 patients (27%). The follow up was based on clinical data. Operative mortality was 5% (n = 17). There were 49 late deaths (5.2%/pt-yr). Valve-related mortality occurred in 10 patients (1%/pt-yr). Actuarial survival at five and 10 years was 78% and 33%, respectively. Actuarial freedom from valve reoperation and structural valve deterioration at 10 years were 100% and 64%. Actuarial freedom from embolic events and endocarditis at 10 years were 84% and 81%, respectively. The ELSV, when implanted as a miniroot, provided good early and long-term results in terms of survival and freedom from major complications.

  10. 76 FR 24523 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... under specified circumstances. Specifically, TMG Technologie and Engineering GmbH, Karlsruhe, GERMANY... 79024). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2011-10466 Filed...

  11. 78 FR 67399 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ..., Leinfelden-Echterdingen, GERMANY; Systeme Helmholz GmbH, Grossenseebach, GERMANY; C.E. Electronics, Inc... Machine Works, Ltd., Nishikasugai-gun, Aichi, JAPAN; Camozzi SpA, Brescia, ITALY; Racine Federated, Inc...

  12. 77 FR 75191 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... under specified circumstances. Specifically, YJS Co., Ltd., Bucheon City, Gyeonggi-Do, Republic of Korea..., Germany; Altera Corporation, San Jose, CA; 3S-Smart Software Solutions GmbH, Kempten, Germany; Branson...

  13. Interaction of Elastic Waves with Corrosion Damage

    DTIC Science & Technology

    2010-08-01

    Joachim Schneider -Gloetzl, Gloetzl GmbH, Rheinstetten, Germany Rainer Gloetzl, RG Research, Ettlingen, Germany...Katerina Krebber, Sascha Liehr, Mario Wendt, Aleksander Wosniok, BAM, Federal Institute for Materials, Research and Testing, Berlin, Germany

  14. Redox-Enabled, pH-Disabled Pyrazoline-Ferrocene INHIBIT Logic Gates.

    PubMed

    Scerri, Glenn J; Cini, Miriam; Schembri, Jonathan S; da Costa, Paola F; Johnson, Alex D; Magri, David C

    2017-07-05

    Pyrazoline-ferrocene conjugates with an "electron-donor-spacer-fluorophore-receptor" format are demonstrated as redox-fluorescent two-input INHIBIT logic gates. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. 76 FR 27861 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... condition as: Since 2004, more than 30 reports have been received of in-flight loss of a rear passenger door... primary locking mechanism provided adequate strength to react to the loads in flight. It was also...

  16. 76 FR 59950 - Airworthiness Directives; BRP-Powertrain GMBH & CO KG 914 F2, 914 F3, and 914 F4 Reciprocating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ...: Deliver to Mail address above between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays... Friday, except Federal holidays. The AD docket contains this proposed AD, the regulatory evaluation, any... 100246 inclusive. 100248 through 100280 inclusive. 100282 through 100293 inclusive. 100295 through 100314...

  17. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (General Image Engineering Corp - H E H Heins GMBH)

    DTIC Science & Technology

    1993-01-01

    CDO-4 zaw O il E sOO Mcq it 0 0 0 0 0 0D (’AN 00 ɜ 1 MI 10 3a’COON U.L 1-1 Ui. 4 -. C>O - LA- WA 1-1 La-O)OC 1-14- Wr2CO iO z- 0 0) 01 a 00 0 0 0 0 4...0 c) tun r- 1-1 In a) cli In r- f-- to <> V) r- r- I- -i ,1 14 ed < o c) 11 00 (0 (0 (D (10 Z) (0 00 0 C> o C> 00 (Tf o 00 C) C, 00 qzr 00-4 r- t- P

  18. METimage: an innovative multi-spectral imaging radiometer for the EUMETSAT polar system follow-on satellite mission

    NASA Astrophysics Data System (ADS)

    Alpers, Matthias; Brüns, Christian; Pillukat, Alexander

    2017-11-01

    The evolving needs of the meteorological community concerning the EUMETSAT Polar System follow-on satellite mission (Post-EPS) require the development of a high-performance multi-spectral imaging radiometer. Recognizing these needs, Jena Optronik GmbH proposed an innovative instrument concept, which comprises a high flexibility to adapt to user requirements as a very important feature. Core parameters like ground sampling distance (GSD), number and width of spectral channels, signal-to-noise ratio, polarization control and calibration facilities can be chosen in a wide range without changing the basic instrument configuration. Core item of the METimage instrument is a rotating telescope scanner to cover the large swath width of about 2800 km, which all polar platforms need for global coverage. The de-rotated image facilitates use of in-field spectral channel separation, which allows tailoring individual channel GSD (ground sampling distance) and features like TDI (time delay and integration). State-of-the-art detector arrays and readout electronics can easily be employed. Currently, the German DLR Space Agency, Jena- Optronik GmbH and AIM Infrarot Module GmbH work together implementing core assemblies of METimage: the rotating telescope scanner and the infrared detectors. The METimage instrument phase B study was kicked-off in September 2008. Germany intents to provide METimage as an in-kind contribution of the first METimage flight model to the EUMETSAT Post-EPS Programme.

  19. 76 FR 17620 - University of Colorado, et al.; Notice of Decision on Applications for Duty-Free Entry of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... High Speed Nd: YAG laser system. Manufacturer: Edgewave GmbH, Germany. Intended Use: See notice at 76... the laser, which is particularly suited for the necessary application, is the beam profile (M\\2\\ ...

  20. Wearable Self-Charging Power Textile Based on Flexible Yarn Supercapacitors and Fabric Nanogenerators.

    PubMed

    Pu, Xiong; Li, Linxuan; Liu, Mengmeng; Jiang, Chunyan; Du, Chunhua; Zhao, Zhenfu; Hu, Weiguo; Wang, Zhong Lin

    2016-01-06

    A novel and scalable self-charging power textile is realized by combining yarn supercapacitors and fabric triboelectric nanogenerators as energy-harvesting devices. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Biotechnology essay competition: biotechnology and sustainable food practices.

    PubMed

    Peng, Judy; Schoeb, Helena; Lee, Gina

    2013-06-01

    Biotechnology Journal announces our second biotechnology essay competition with the theme "biotechnology and sustainable food practices", open to all undergraduate students. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Suction and cohesion demise in desaturating granular medium

    NASA Astrophysics Data System (ADS)

    Hueckel, T.; Mielniczuk, B.; El-Youssoufi, S. M.

    2017-12-01

    Continuum mechanics for unsaturated soils is based on the assumption of a one-to-one relationship betwee saturation degree and suction represented by the characteristic curve. Such curve commonly shows exceedingly high values of suction at saturation decreasing below 10%. We have performed a series of experiments on physical micro-structural models of 8-, 5, 4, 3, and 2-grain assemblies filled with water forming capillary, funicular and pendular bridges. Dynamic variables characterizing the evolution include: Laplace pressure, surface tension force, total intergralular force, contact angle and contact perimeter length. The Laplace pressure was calculated from the directly measured curvatures of interface surface for 2-grain bridges, and estimated from tomography stills for 3 grain bridges. The initial negative Laplace pressure (suction) as well as total intergranular force increase modestly at the begining of evaporation, but undergo an unstable decrease at the advanced stage, often with a jump in the force known as a Haines jumps since 1925. Laplace pressure turns into positive values prior to rupture for 2-grain bodies. For 3-grain bridges there is never an exceedingly high intergranular force of suction, reported in macro-scale experiments. For multiple-grain bodies there are two types of instabilities, depending on densitiy of the assembly and the Gaussian curvature (GC): at positive GC points it is thin-sheet instability, while at negative GC points instability is linked with air entry fingers, all associated with the split of assemblies into smaller isolated funicular, and eventually pendular bodies. The multi-grain bridges instabilities are linked to material drying cracking, the instabilities in 2 grain systems mean eventual loss of cohesion.

  3. Towards Improved Estimates of Ocean Heat Flux

    NASA Astrophysics Data System (ADS)

    Bentamy, Abderrahim; Hollman, Rainer; Kent, Elisabeth; Haines, Keith

    2014-05-01

    Recommendations and priorities for ocean heat flux research are for instance outlined in recent CLIVAR and WCRP reports, eg. Yu et al (2013). Among these is the need for improving the accuracy, the consistency, and the spatial and temporal resolution of air-sea fluxes over global as well as at region scales. To meet the main air-sea flux requirements, this study is aimed at obtaining and analyzing all the heat flux components (latent, sensible and radiative) at the ocean surface over global oceans using multiple satellite sensor observations in combination with in-situ measurements and numerical model analyses. The fluxes will be generated daily and monthly for the 20-year (1992-2011) period, between 80N and 80S and at 0.25deg resolution. Simultaneous estimates of all surface heat flux terms have not yet been calculated at such large scale and long time period. Such an effort requires a wide range of expertise and data sources that only recently are becoming available. Needed are methods for integrating many data sources to calculate energy fluxes (short-wave, long wave, sensible and latent heat) across the air-sea interface. We have access to all the relevant, recently available satellite data to perform such computations. Yu, L., K. Haines, M. Bourassa, M. Cronin, S. Gulev, S. Josey, S. Kato, A. Kumar, T. Lee, D. Roemmich: Towards achieving global closure of ocean heat and freshwater budgets: Recommendations for advancing research in air-sea fluxes through collaborative activities. INTERNATIONAL CLIVAR PROJECT OFFICE, 2013: International CLIVAR Publication Series No 189. http://www.clivar.org/sites/default/files/ICPO189_WHOI_fluxes_workshop.pdf

  4. Preference for sons: past and present.

    PubMed

    Li, D

    1997-10-01

    This brief article discusses the present and past preference for sons in China. The preference for sons is rooted in feudal views that men are superior to women. Preference for sons dates back to the Warring States Period, in about 500 B.C. Clan brotherhoods of men have existed for centuries. Historical records mention the practice of female infanticide. Patriarchal families believed that women were economically dependent on men and thus became their subjects. Daughters married, lived in their husband's home, and did not carry the responsibility of caring for their own parents. Couples with only daughters would seek a son-in-law to support them in old age. Rural families with no sons were looked down upon. Sons were expected to carry on the family lineage, increase the reputation of the family, and protect the family's interests. The lack of sons was a sign of humiliation and a curse. The founding of the People's Republic of China brought changes to son preference. The government attempted to increase women's status. In rural areas, women were given equal access to the land. Job opportunities were created for women during the industrialization drive. The Chinese government encouraged the repudiation of the negative impacts of the doctrines of Confucius and Mencius. Efforts were made to give men and women equal pay for equal work. Legislation was passed prohibiting arranged marriage, polygyny, and early marriage. A side effect of fertility decline is the renewed preference for sons. In Huangyan and Haining in Zhejiang, a developed province, the sex ratio at birth is normal. Sexual division of labor reinforces son preference.

  5. Position control of twisted and coiled polymer actuator using a controlled fan for cooling

    NASA Astrophysics Data System (ADS)

    Takagi, Kentaro; Arakawa, Takeshi; Takeda, Jun; Masuya, Ken; Tahara, Kenji; Asaka, Kinji

    2017-04-01

    Recently, artificial muscles made of fishing lines or sewing threads, namely twisted and coiled polymer actuators (TCPAs), have been proposed by Haines et al. A TCPA contracts by applying heat and returns to its initial length by cooling. A TCPA can be driven by voltage if the TCPA is plated by metal or if conductive wire such as nichrome is wound around it. Compared with the conventional electroactive polymers, advantages of TCPAs are low cost, simple structure, large actuation strain, and large force. However, a big disadvantage of TCPAs is slow response due to heat transfer. The problem becomes apparent during cooling, although the response of heating can be improved by feedback control. This paper proposes a control method of switching heating and cooling. In the proposed method, a TCPA is cooled by an electric cooling fan. When the TCPA is heating, the cooling fan is stopped. In a previous report, the response speed can be improved by keeping cooling fan always on; however, unnecessary energy consumption is required even during heating. In the proposed method, energy consumption during heating does not increase and the response speed can be improved using fan only during cooling. The proposed control law is as follows. Firstly, the desired control input is determined by PI-D control with respect to the length of the actuator. Then, the control inputs to the heater and to the cooling fan are switched according to the sign of the PI-D controller output. The effectiveness of the proposed control method is demonstrated by comparing the cases with and without the cooling fan in the experiments.

  6. Supporting students in building interdisciplinary connections across physics and biology

    NASA Astrophysics Data System (ADS)

    Turpen, Chandra

    2014-03-01

    Our research team has been engaged in the iterative redesign of an Introductory Physics course for Life Science (IPLS) majors to explicitly bridge biology and physics in ways that are authentic to the disciplines. Our interdisciplinary course provides students opportunities to examine how modeling decisions (e.g. knowing when and how to use different concepts, identifying implicit assumptions, making and justifying assumptions) may differ depending on canonical disciplinary aims and interests. Our focus on developing students' interdisciplinary reasoning skills requires 1) shifting course topics to focus on core ideas that span the disciplines, 2) shifting epistemological expectations, and 3) foregrounding typically tacit disciplinary assumptions. In working to build an authentic interdisciplinary course that bridges physics and biology, we pay careful attention to supporting students in constructing these bridges. This course has been shown to have important impacts: a) students seek meaningful connections between the disciplines, b) students perceive relevance and utility of ideas from different disciplines, and c) students reconcile challenging disciplinary ideas. Although our focus has been on building interdisciplinary coherence, we have succeeded in maintaining strong student learning gains on fundamental physics concepts and allowed students to deepen their understanding of challenging concepts in thermodynamics. This presentation will describe the shifts in course content and the modern pedagogical approaches that have been integrated into the course, and provide an overview of key research results from this project. These results may aid physicists in reconsidering how they can meaningfully reach life-science students. This work is supported by NSF-TUES DUE 11-22818, the HHMI NEXUS grant, and a NSF Graduate Research Fellowship (DGE 0750616).

  7. An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy

    DOE PAGES

    Howells, M. R.; Beetz, T.; Chapman, H. N.; ...

    2008-11-17

    X-ray diffraction microscopy (XDM) is a new form of x-ray imaging that is being practiced at several third-generation synchrotron-radiation x-ray facilities. Nine years have elapsed since the technique was first introduced and it has made rapid progress in demonstrating high-resolution three-dimensional imaging and promises few-nm resolution with much larger samples than can be imaged in the transmission electron microscope. Both life- and materials-science applications of XDM are intended, and it is expected that the principal limitation to resolution will be radiation damage for life science and the coherent power of available x-ray sources for material science. In this paper wemore » address the question of the role of radiation damage. We use a statistical analysis based on the so-called "dose fractionation theorem" of Hegerl and Hoppe to calculate the dose needed to make an image of a single life-science sample by XDM with a given resolution. We find that for simply-shaped objects the needed dose scales with the inverse fourth power of the resolution and present experimental evidence to support this finding. To determine the maximum tolerable dose we have assembled a number of data taken from the literature plus some measurements of our own which cover ranges of resolution that are not well covered otherwise. The conclusion of this study is that, based on the natural contrast between protein and water and "Rose-criterion" image quality, one should be able to image a frozen-hydrated biological sample using XDM at a resolution of about 10 nm.« less

  8. Achievements and Challenges in Computational Protein Design.

    PubMed

    Samish, Ilan

    2017-01-01

    Computational protein design (CPD), a yet evolving field, includes computer-aided engineering for partial or full de novo designs of proteins of interest. Designs are defined by a requested structure, function, or working environment. This chapter describes the birth and maturation of the field by presenting 101 CPD examples in a chronological order emphasizing achievements and pending challenges. Integrating these aspects presents the plethora of CPD approaches with the hope of providing a "CPD 101". These reflect on the broader structural bioinformatics and computational biophysics field and include: (1) integration of knowledge-based and energy-based methods, (2) hierarchical designated approach towards local, regional, and global motifs and the integration of high- and low-resolution design schemes that fit each such region, (3) systematic differential approaches towards different protein regions, (4) identification of key hot-spot residues and the relative effect of remote regions, (5) assessment of shape-complementarity, electrostatics and solvation effects, (6) integration of thermal plasticity and functional dynamics, (7) negative design, (8) systematic integration of experimental approaches, (9) objective cross-assessment of methods, and (10) successful ranking of potential designs. Future challenges also include dissemination of CPD software to the general use of life-sciences researchers and the emphasis of success within an in vivo milieu. CPD increases our understanding of protein structure and function and the relationships between the two along with the application of such know-how for the benefit of mankind. Applied aspects range from biological drugs, via healthier and tastier food products to nanotechnology and environmentally friendly enzymes replacing toxic chemicals utilized in the industry.

  9. Catheter Ablation of Focal Atrial Tachycardia Using Remote Magnetic Navigation.

    PubMed

    Webster, Mark; Pasupati, Sanjeevan; Lever, Nigel; Stiles, Martin

    2018-05-01

    This first-in-human study evaluated the safety and technical feasibility of the Tempo temporary cardiac pacing lead (BioTrace Medical), which includes a novel fixation mechanism and soft tip. Complications of temporary pacing leads include dislodgment, arrhythmias, and ventricular perforation. Temporary pacing applications have increased with transcatheter aortic valve replacement (TAVR) growth, for rapid pacing during balloon valvuloplasty (BAV) and valve deployment, and for periprocedural bradyarrhythmia support. Eligible patients required temporary pacing for TAVR, BAV, or electrophysiology (EP) procedures. Transthoracic echocardiograms were obtained at baseline and 24 hours after lead removal. Safety was defined as freedom from pericardial effusion requiring intervention or evidence of tamponade. Technical feasibility involved successful intracardiac delivery and pace capture. Additional evaluations included pacing threshold (PCT), rapid pacing, dislodgment, or sustained ventricular arrhythmias. Follow-up was to 30 days. Twenty-five patients (60% female; mean age, 64 ± 19 years) underwent 13 TAVRs (7 Sapien 3 valves [Edwards Lifesciences], 4 CoreValves [Medtronic], and 2 Lotus valves [Boston Scientific]), 11 EP procedures, and 1 BAV at two New Zealand centers from January 2016 to June 2016. Safety was met in all patients, with no device-related adverse events. Technical feasibility was achieved in 23 cases (92%); 2 patients had unsuitable anatomy. No patient had lead dislodgment or sustained ventricular arrhythmias, and the final procedural PCT was 0.7 ± 0.5 mA. Rapid pacing was successful in all cases. Five patients had successful postprocedural use up to 5 days. This first-in-human study demonstrates the safety and technical feasibility of the Tempo lead, providing stable periprocedural temporary pacing support.

  10. Embolic capture with updated intra-aortic filter during coronary artery bypass grafting and transaortic transcatheter aortic valve implantation: first-in-human experience.

    PubMed

    Ye, Jian; Webb, John G

    2014-12-01

    We report our first-in-human clinical experience in the use of the new version of the EMBOL-X intra-aortic filter (Edwards Lifesciences Corporation, Irvine, Calif) to capture embolic material during transaortic transcatheter aortic valve implantation and cardiac surgery. Five patients were enrolled into the first-in-human clinical assessment of the new version of the EMBOL-X intra-aortic filter. Three patients underwent coronary artery bypass grafting, and 2 patients underwent transaortic transcatheter aortic valve implantation. During coronary artery bypass grafting, the filter was deployed before clamping of the aorta and removal of the aortic clamp. In contrast, the filter was deployed before aortic puncture for transaortic transcatheter aortic valve implantation and kept in the aorta throughout the entire procedure. The filter introducer sheath and filter were easily placed and removed without difficulty. There were no complications related to the use of the filter. Postoperative examination of the retrieved filters revealed the presence of multiple microemboli in the filters from all 5 cases. Histologic study revealed various kinds of tissue and thrombus. This first-in-human clinical experience has demonstrated the safety and feasibility of using the new version of the EMBOL-X intra-aortic filter during either cardiac surgery or transaortic transcatheter aortic valve implantation. We believe that the combination of the transaortic approach without aortic arch manipulation and the use of the EMBOL-X filter with a high capture rate is a promising strategy to reduce the incidence of embolic complications during transcatheter aortic valve implantation. Copyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

  11. One-year multicentre outcomes of transapical aortic valve implantation using the SAPIEN XT™ valve: the PREVAIL transapical study.

    PubMed

    Walther, Thomas; Thielmann, Matthias; Kempfert, Joerg; Schroefel, Holger; Wimmer-Greinecker, Gerhard; Treede, Hendrik; Wahlers, Thorsten; Wendler, Olaf

    2013-05-01

    The study aimed to evaluate 1-year outcomes of the multicentre PREVAIL transapical (TA) study of TA-aortic valve implantation (AVI) in high-risk patients. From September 2009 to August 2010, a total of 150 patients, aged 81.6 ± 5.8 years, 40.7% female, were included at 12 European TA-AVI experienced sites. Patients received 23 (n = 36), 26 (n = 57) and 29 mm (n = 57) second-generation SAPIEN XT™ (Edwards Lifesciences, Irvine, CA, USA) valves. The mean logistic EuroSCORE was 24.3 ± 7.0, and mean Society Thoracic Surgeons score was 7.5 ± 4.4%. Survival was 91.3% at 30 days and 77.9% at 1 year. Subgroup analysis revealed survivals of 91.7/88.9, 86.0/70.2, 96.55/91.2% for patients receiving 23-, 26- and 29-mm valves at 30 days and at 1 year, respectively. Transthoracic echocardiography revealed preserved left ventricular ejection fraction and low gradients. Aortic incompetence was none in 41/48, trace 30/36, mild 22/12 and moderate in 7/4% at discharge and 1 year. Walking distance increased from 221 (postimplant) to 284 m (at 1 year, P = 0.0004). Three patients required reoperation due to increasing aortic incompetence during follow-up. Causes of mortality at 1 year were cardiac (n = 7), stroke (n = 1) and others (n = 5). The European PREVAIL multicentre trial demonstrates good functionality and good outcomes for TA-AVI using the second-generation SAPIEN XT prosthesis and the ASCENDRA-II delivery system. The 29-mm SAPIEN XT valve was successfully introduced and showed excellent results.

  12. Exact and approximate solutions for the decades-old Michaelis-Menten equation: Progress-curve analysis through integrated rate equations.

    PubMed

    Goličnik, Marko

    2011-01-01

    The Michaelis-Menten rate equation can be found in most general biochemistry textbooks, where the time derivative of the substrate is a hyperbolic function of two kinetic parameters (the limiting rate V, and the Michaelis constant K(M) ) and the amount of substrate. However, fundamental concepts of enzyme kinetics can be difficult to understand fully, or can even be misunderstood, by students when based only on the differential form of the Michaelis-Menten equation, and the variety of methods available to calculate the kinetic constants from rate versus substrate concentration "textbook data." Consequently, enzyme kinetics can be confusing if an analytical solution of the Michaelis-Menten equation is not available. Therefore, the still rarely known exact solution to the Michaelis-Menten equation is presented here through the explicit closed-form equation in terms of the Lambert W(x) function. Unfortunately, as the W(x) is not available in standard curve-fitting computer programs, the practical use of this direct solution is limited for most life-science students. Thus, the purpose of this article is to provide analytical approximations to the equation for modeling Michaelis-Menten kinetics. The elementary and explicit nature of these approximations can provide students with direct and simple estimations of kinetic parameters from raw experimental time-course data. The Michaelis-Menten kinetics studied in the latter context can provide an ideal alternative to the 100-year-old problems of data transformation, graphical visualization, and data analysis of enzyme-catalyzed reactions. Hence, the content of the course presented here could gradually become an important component of the modern biochemistry curriculum in the 21st century. Copyright © 2011 Wiley Periodicals, Inc.

  13. Design and installation of a multimode microscopy system

    NASA Astrophysics Data System (ADS)

    Helm, Johannes P.; Haug, Finn-Mogens S.; Storm, Johan F.; Ottersen, Ole-Petter

    2001-04-01

    We describe design and installation of a multi-mode microscopy core facility in an environment of varied research activity in life-sciences. The experimentators can select any combination of a) microscopes (upright, upright fixed-stage, inverted), b) microscopy modes (widefield, DIC, IRDIC, widefield epifluorescence, transmission LSM, reflection and fluorescence CLSM, MPLSM), c) imaging techniques (direct observation, video observation, photography, quantitative camera-recording, flying spot scanning), d) auxiliary systems (equipment for live specimen imaging, electrophysiology, time-coordinated laser-scanning and electrophysiology, patch-clamp). The equipment is installed on one large vibration-isolating optical table (3m X 1.5m X 0.3m). Electronics, auxiliary equipment, and a fiber-coupled, remotely controlled Ar+-Kr+ laser are mounted in a rack system fixed to the ceiling. The design of the shelves allows the head of the CSLM to be moved to any of the microscopes without increasing critical cable lengths. At the same time easy access to all the units is preserved. The beam of a Titanium-Sapphire laser, controlled by means of an EOM and a prism GVD, is coupled directly to the microscopes. Three mirrors mounted on a single precision translation table are integrated into the beam steering system so that the beam can easily be redirected to any of the microscopes. All the available instruments can be operated by the educated and trained user. The system is popular among researchers in neuroanatomy, embryology, cell biology, molecular biology - including the study of protein interactions, e.g. by means of FRET, and electrophysiology. Its colocalization with an EM facility promises to provide considerable synergy effects.

  14. Bioprosthetic Valve Fracture to Facilitate Transcatheter Valve-in-Valve Implantation.

    PubMed

    Allen, Keith B; Chhatriwalla, Adnan K; Cohen, David J; Saxon, John T; Aggarwal, Sanjeev; Hart, Anthony; Baron, Suzanne; Davis, J Russell; Pak, Alex F; Dvir, Danny; Borkon, A Michael

    2017-11-01

    Valve-in-valve transcatheter aortic valve replacement is less effective in small surgical bioprostheses. We evaluated the feasibility of bioprosthetic valve fracture with a high-pressure balloon to facilitate valve-in-valve transcatheter aortic valve replacement. In vitro bench testing on aortic tissue valves was performed on 19-mm and 21-mm Mitroflow (Sorin, Milan, Italy), Magna and Magna Ease (Edwards Lifesciences, Irvine, CA), Trifecta and Biocor Epic (St. Jude Medical, Minneapolis, MN), and Hancock II and Mosaic (Medtronic, Minneapolis, MN). High-pressure balloons Tru Dilation, Atlas Gold, and Dorado (C.R. Bard, Murray Hill, NJ) were used to determine which valves could be fractured and at what pressure fracture occurred. Mitroflow, Magna, Magna Ease, Mosaic, and Biocor Epic surgical valves were successfully fractured using high-pressures balloon 1 mm larger than the labeled valve size whereas Trifecta and Hancock II surgical valves could not be fractured. Only the internal valve frame was fractured, and the sewing cuff was never disrupted. Manufacturer's rated burst pressures for balloons were exceeded, with fracture pressures ranging from 8 to 24 atmospheres depending on the surgical valve. Testing further demonstrated that fracture facilitated the expansion of previously constrained, underexpanded transcatheter valves (both balloon and self-expanding) to the manufacturer's recommended size. Bench testing demonstrates that the frame of most, but not all, bioprosthetic surgical aortic valves can be fractured using high-pressure balloons. The safety of bioprosthetic valve fracture to optimize valve-in-valve transcatheter aortic valve replacement in small surgical valves requires further clinical investigation. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  15. Synthesis of Trifluoromethylthiolated Alkenes and Ketones by Decarboxylative Functionalization of Cinnamic Acids.

    PubMed

    Pan, Shen; Huang, Yangen; Qing, Feng-Ling

    2016-10-20

    A tunable decarboxylative trifluoromethylthiolation of cinnamic acids with AgSCF 3 was developed to afford trifluoromethylthiolated alkenes or ketones by using transition metal-mediated conditions. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Topology Optimized Architectures with Programmable Poisson's Ratio over Large Deformations.

    PubMed

    Clausen, Anders; Wang, Fengwen; Jensen, Jakob S; Sigmund, Ole; Lewis, Jennifer A

    2015-10-07

    Topology optimized architectures are designed and printed with programmable Poisson's ratios ranging from -0.8 to 0.8 over large deformations of 20% or more. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Design Framework Validation for a Hot Spot on Complex Aircraft Structures

    DTIC Science & Technology

    2010-08-01

    LEONARD, S. E. OLSON AND M. P. DESIMIO Joachim Schneider -Gloetzl, Gloetzl GmbH, Rh instetten, Germany...Rainer Gloetzl, RG Research, Ettlingen, Ger any Katerina Krebber, Sascha Liehr, Mario Wendt, Aleksander Wosniok, BAM, Federal Institute for

  18. 3D WO3 /BiVO4 /Cobalt Phosphate Composites Inverse Opal Photoanode for Efficient Photoelectrochemical Water Splitting.

    PubMed

    Zhang, Haifeng; Zhou, Weiwei; Yang, Yaping; Cheng, Chuanwei

    2017-04-01

    A novel 3D WO 3 /BiVO 4 /cobalt phosphate composite inverse opal is designed for photoeletrochemical (PEC) water splitting, yielding a significantly improved PEC performance. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Efficient Generation of Long-Lived Triplet Excitons in 2D Hybrid Perovskite.

    PubMed

    Younts, Robert; Duan, Hsin-Sheng; Gautam, Bhoj; Saparov, Bayrammurad; Liu, Jie; Mongin, Cedric; Castellano, Felix N; Mitzi, David B; Gundogdu, Kenan

    2017-03-01

    Triplet excitons form in quasi-2D hybrid inorganic-organic perovskites and diffuse over 100 nm before radiating with >11% photoluminescence quantum efficiency (PLQE) at low temperatures. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Pentalenes--from highly reactive antiaromatics to substrates for material science.

    PubMed

    Hopf, Henning

    2013-11-18

    Antimatter: Once studied primarily for their antiaromatic properties, pentalenes are rapidly becoming important π-systems for novel electronic materials. Recent developments in this area are summarized. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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