[Heavy metal pollution characteristics and ecological risk analysis for soil around Haining electroplating industrial park].

PubMed

Li, Jiong-Hui; Weng, Shan; Fang, Jing; Huang, Jia-Lei; Lu, Fang-Hua; Lu, Yu-Hao; Zhang, Hong-Ming

2014-04-01

The pollution status and potential ecological risks of heavy metal in soils around Haining electroplating industrial park were studied. Hakanson index approach was used to assess the ecological hazards of heavy metals in soils. Results showed that average concentrations of six heavy metals (Cu, Ni, Pb, Zn, Cd and Cr) in the soils were lower than the secondary criteria of environmental quality standard for soils, indicating limited harmful effects on the plants and the environment in general. Though the average soil concentrations were low, heavy metal concentrations in six sampling points located at the side of road still exceeded the criteria, with excessive rate of 13%. Statistic analysis showed that concentrations of Cu and Cd in roadside soils were significantly higher than those in non-roadside soils, indicating that the excessive heavy metal accumulations in the soil closely related with traffic transport. The average potential ecological hazard index of soils around Haining electroplating industrial park was 46.6, suggesting a slightly ecological harm. However, the potential ecological hazard index of soils with excessive heavy metals was 220-278, suggesting the medium ecological hazards. Cd was the most seriously ecological hazard factor.

Using Haines Index coupled with fire weather model predicted from high resolution LAM forecasts to asses wildfire extreme behaviour in Southern Europe.

NASA Astrophysics Data System (ADS)

Gaetani, Francesco; Baptiste Filippi, Jean; Simeoni, Albert; D'Andrea, Mirko

2010-05-01

Haines Index (HI) was developed by USDA Forest Service to measure the atmosphere's contribution to the growth potential of a wildfire. The Haines Index combines two atmospheric factors that are known to have an effect on wildfires: Stability and Dryness. As operational tools, HI proved its ability to predict plume dominated high intensity wildfires. However, since HI does not take into account the fuel continuity, composition and moisture conditions and the effects of wind and topography on fire behaviour, its use as forecasting tool should be carefully considered. In this work we propose the use of HI, predicted from HR Limited Area Model forecasts, coupled with a Fire Weather model (i.e., RISICO system) fully operational in Italy since 2003. RISICO is based on dynamic models able to represent in space and in time the effects that environment and vegetal physiology have on fuels and, in turn, on the potential behaviour of wildfires. The system automatically acquires from remote databases a thorough data-set of input information both of in situ and spatial nature. Meteorological observations, radar data, Limited Area Model weather forecasts, EO data, and fuel data are managed by a Unified Interface able to process a wide set of different data. Specific semi-physical models are used in the system to simulate the dynamics of the fuels (load and moisture contents of dead and live fuel) and the potential fire behaviour (rate of spread and linear intensity). A preliminary validation of this approach will be provided with reference to Sardinia and Corsica Islands, two major islands of the Mediterranean See frequently affected by extreme plume dominated wildfires. A time series of about 3000 wildfires burnt in Sardinia and Corsica in 2007 and 2008 will be used to evaluate the capability of HI coupled with the outputs of the Fire Weather model to forecast the actual risk in time and in space.

77 FR 74508 - Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

... Statement for the Ring of Fire Resource Management Plan--Haines Planning Area, Alaska AGENCY: Bureau of Land.../Draft Environmental Impact Statement (EIS) for the Ring of Fire RMP for the Haines Planning Area and by... Fire RMP-- Haines Planning Area Amendment by any of the following methods: Email: [email protected

Keeping Haines Real - Or Really Changing Haines?

Treesearch

Brian E. Potter; Dan Borsum; Don Haines

2002-01-01

Most incident command teams can handle low- to moderate-intensity fires with few unanticipated problems. However, high-intensity situations, especially the plume-dominated fires that often develop when winds are low and erratic behavior is unexpected, can create dangerous situations even for well-trained, experienced fire crews (Rothermel 1991). Plume-dominated fires...

75 FR 16822 - Federal Property Suitable as Facilities To Assist the Homeless

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-02

... FURTHER INFORMATION CONTACT: Kathy Ezzell, Department of Housing and Urban Development, 451 Seventh Street... ALASKA Dalton-Cache Border Station Mile 42 Haines Highway Haines AK 99827 Landholding Agency: GSA...

Testing of the high accuracy inertial navigation system in the Shuttle Avionics Integration Lab

NASA Technical Reports Server (NTRS)

Strachan, Russell L.; Evans, James M.

1991-01-01

The description, results, and interpretation is presented of comparison testing between the High Accuracy Inertial Navigation System (HAINS) and KT-70 Inertial Measurement Unit (IMU). The objective was to show the HAINS can replace the KT-70 IMU in the space shuttle Orbiter, both singularly and totally. This testing was performed in the Guidance, Navigation, and Control Test Station (GTS) of the Shuttle Avionics Integration Lab (SAIL). A variety of differences between the two instruments are explained. Four, 5 day test sessions were conducted varying the number and slot position of the HAINS and KT-70 IMUs. The various steps in the calibration and alignment procedure are explained. Results and their interpretation are presented. The HAINS displayed a high level of performance accuracy previously unseen with the KT-70 IMU. The most significant improvement of the performance came in the Tuned Inertial/Extended Launch Hold tests. The HAINS exceeded the 4 hr specification requirement. The results obtained from the SAIL tests were generally well beyond the requirements of the procurement specification.

Geochemical reanalysis of historical U.S. Geological Survey sediment samples from the Haines area, Juneau and Skagway quadrangles, southeast Alaska

USGS Publications Warehouse

Werdon, Melanie B.; Granitto, Matthew; Azain, Jaime S.

2015-01-01

The State of Alaska’s Strategic and Critical Minerals (SCM) Assessment project, a State-funded Capital Improvement Project (CIP), is designed to evaluate Alaska’s statewide potential for SCM resources. The SCM Assessment is being implemented by the Alaska Division of Geological & Geophysical Surveys (DGGS), and involves obtaining new airborne-geophysical, geological, and geochemical data. As part of the SCM Assessment, thousands of historical geochemical samples from DGGS, U.S. Geological Survey (USGS), and U.S. Bureau of Mines archives are being reanalyzed by DGGS using modern, quantitative, geochemical-analytical methods. The objective is to update the statewide geochemical database to more clearly identify areas in Alaska with SCM potential. The USGS is also undertaking SCM-related geologic studies in Alaska through the federally funded Alaska Critical Minerals cooperative project. DGGS and USGS share the goal of evaluating Alaska’s strategic and critical minerals potential and together created a Letter of Agreement (signed December 2012) and a supplementary Technical Assistance Agreement (#14CMTAA143458) to facilitate the two agencies’ cooperative work. Under these agreements, DGGS contracted the USGS in Denver to reanalyze historical USGS sediment samples from Alaska. For this report, DGGS funded reanalysis of 212 historical USGS sediment samples from the statewide Alaska Geochemical Database Version 2.0 (AGDB2; Granitto and others, 2013). Samples were chosen from the Chilkat, Klehini, Tsirku, and Takhin river drainages, as well as smaller drainages flowing into Chilkat and Chilkoot Inlets near Haines, Skagway Quadrangle, Southeast Alaska. Additionally some samples were also chosen from the Juneau gold belt, Juneau Quadrangle, Southeast Alaska (fig. 1). The USGS was responsible for sample retrieval from the National Geochemical Sample Archive (NGSA) in Denver, Colorado through the final quality assurance/quality control (QA/QC) of the geochemical

2. Historic American Buildings Survey, August, 1971 STREETSCAPE SHOWING EAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, August, 1971 STREETSCAPE SHOWING EAST (FRONT) ELEVATIONS OF HAINES BROTHERS BRICK STORE (FAR RIGHT), ORTH BUILDING, BRUNNER BROTHERS STORE, AND NORTH (FRONT) ELEVATION OF CITY HALL (FAR LEFT). - Haines Brothers Brick Store, 110 South Oregon Street, Jacksonville, Jackson County, OR

Lattice Boltzmann simulations of supercritical CO2-water drainage displacement in porous media: CO2 saturation and displacement mechanism.

PubMed

Yamabe, Hirotatsu; Tsuji, Takeshi; Liang, Yunfeng; Matsuoka, Toshifumi

2015-01-06

CO2 geosequestration in deep aquifers requires the displacement of water (wetting phase) from the porous media by supercritical CO2 (nonwetting phase). However, the interfacial instabilities, such as viscous and capillary fingerings, develop during the drainage displacement. Moreover, the burstlike Haines jump often occurs under conditions of low capillary number. To study these interfacial instabilities, we performed lattice Boltzmann simulations of CO2-water drainage displacement in a 3D synthetic granular rock model at a fixed viscosity ratio and at various capillary numbers. The capillary numbers are varied by changing injection pressure, which induces changes in flow velocity. It was observed that the viscous fingering was dominant at high injection pressures, whereas the crossover of viscous and capillary fingerings was observed, accompanied by Haines jumps, at low injection pressures. The Haines jumps flowing forward caused a significant drop of CO2 saturation, whereas Haines jumps flowing backward caused an increase of CO2 saturation (per injection depth). We demonstrated that the pore-scale Haines jumps remarkably influenced the flow path and therefore equilibrium CO2 saturation in crossover domain, which is in turn related to the storage efficiency in the field-scale geosequestration. The results can improve our understandings of the storage efficiency by the effects of pore-scale displacement phenomena.

Note on Conditional Compilation in Standard ML

DTIC Science & Technology

1993-06-01

eOmputer-Science No-te on Coridhitiom Cominliati"I~n Standard ML1 Nicholas Haines Edoardo Biagioni Robert Hiarper mom Brian G. Mimnes June 1993 CMU...CS-93. 11 TIC ELECTE f 00..7733 %goo~~OO Note on Conditioual Compilation in Standard ML Nicholas Haines Edoardo Biagioni Robert Harper Brian G. Milnes

Oral Traditions, Changing Rural Landscapes, and Science Education

ERIC Educational Resources Information Center

Stapleton, Sarah Riggs

2017-01-01

This forum response extends the argument made by Avery and Hains that oral traditions can be useful for including the cultures and contexts of rural areas within science instruction. To buttress the oral expressions presented in Avery and Hains, I compare oral expressions of a second rural area, 600 miles to the South, in Eastern North Carolina. I…

Evidence of Cold Climate Slope Processes from the New Jersey Coastal Plain: Debris Flow Stratigraphy at Haines Corner, Camden County, New Jersey

USGS Publications Warehouse

Newell, Wayne L.

2005-01-01

Excavations through surficial deposits across the New Jersey Coastal Plain commonly reveal homogenized surficial sediments, deformed sedimentary structures, chaotically rearranged bed-forms, and wedge-shaped cracks filled with sand from the top-most layers of extant soil profiles. As a whole, these abundant, broadly distributed phenomena are best explained as artifacts of an era of frozen ground during the last Pleistocene glacial maximum. Vigorous freeze-thaw processes and abundant seasonal rainfall created a landscape of low relief covered by highly mobile surficial deposits. The surficial deposits are at grade into broad, flat bottomed valleys now drained by small, tightly meandering, under-fit streams. Modern fluvial, aeolian, and slope processes are ineffectual in either creating or modifying these landscapes. One particularly brief exposure of complex slope deposits was documented at Haines Corner, Camden County, during the field work (1986) for the Surficial Geologic Map of southern and central New Jersey. The exposure, now presented and interpreted here, provides previously unavailable details of a system of freeze-thaw driven processes that unfolded upon a frozen, impermeable substrate 80 miles south of the southern margin of the Wisconsinan glacial advance to Long Island, N.Y. At the time of these extreme processes, the presently sub-aerial New Jersey Coastal Plain was not proximal to moderating effects of the Atlantic Ocean, being about 100 miles inland and 300 feet above the lowered sea level. Current studies of analogous deposits across the mid-Atlantic Coastal Plain now benefit from dating techniques that were not available during the geologic mapping field work (1985-'92). During the mapping in New Jersey, hundreds of exposures failed to produce datable carbon remains within the stratigraphy of the surficial deposits. Recently reported TL dates from wind-blown sand filling frost wedges, exposed elsewhere in New Jersey, indicate that the widely

Potential industrial sites in the Lynn Canal area, Alaska

USGS Publications Warehouse

Johnson, Arthur; Twenhofel, William Stephens

1953-01-01

Full development of a proposal to divert the headwaters of the Yukon River drainage from Canada into the Taiya River valley of Alaska would make available more than a half million kilowatts of electrical energy. Utilization of this block of power, for which there is at present no local market, will require an industrial and community development of appreciable magnitude. Suitable sites for industrial and community development near the proposed power source are limited because of the extremely rugged and mountainous terrain of the Lynn Canal area. This report considers potential industrial areas at Skagway, Taiya River, Ferebee River, Lutak Inlet, Haines and vicinity, Klukwan and vicinity, Haines to Klukwan along the Haines cutoff, Berners Bay, and Juneau and vicinity. The factors considered in their evaluation are topography, geology, climate, water supply, transportation facilities, and transmission-line routes from the source of power.

Power Scaling of CW and Pulsed IR and Mid-IR OPSLs (Postprint)

DTIC Science & Technology

2013-01-01

T. J. Rotter, G. Balakrishnan, and C. Hains University of New Mexico S. W . Koch, W . Stolz, and B . Kunert University of Marburg...Balakrishnan, and C. Hains (University of New Mexico ) S. W . Koch, W . Stolz, and B . Kunert (University of Marburg) 5d. PROJECT NUMBER 2002 5e. TASK...Yarboroughb, T. J Rotterc, G. Balakrishnanc, C. Hainsc, S.W. Kochd, W . Stolzd, B . Kunertd,R. Bedforde aNonlinear Control Strategies Inc, 3542 N

Solar Water Heater

NASA Technical Reports Server (NTRS)

1993-01-01

As a Jet Propulsion Laboratory (JPL) scientist Dr. Eldon Haines studied the solar energy source and solar water heating. He concluded he could build a superior solar water heating system using the geyser pumping principle. He resigned from JPL to develop his system and later form Sage Advance Corporation to market the technology. Haines' Copper Cricket residential system has no moving parts, is immune to freeze damage, needs no roof-mounted tanks, and features low maintenance. It provides 50-90 percent of average hot water requirements. A larger system, the Copper Dragon, has been developed for commercial installations.

Safety of the lateral trauma position in cervical spine injuries: a cadaver model study.

PubMed

Hyldmo, P K; Horodyski, M B; Conrad, B P; Dubose, D N; Røislien, J; Prasarn, M; Rechtine, G R; Søreide, E

2016-08-01

Endotracheal intubation is not always an option for unconscious trauma patients. Prehospital personnel are then faced with the dilemma of maintaining an adequate airway without risking deleterious movement of a potentially unstable cervical spine. To address these two concerns various alternatives to the classical recovery position have been developed. This study aims to determine the amount of motion induced by the recovery position, two versions of the HAINES (High Arm IN Endangered Spine) position, and the novel lateral trauma position (LTP). We surgically created global cervical instability between the C5 and C6 vertebrae in five fresh cadavers. We measured the rotational and translational (linear) range of motion during the different maneuvers using an electromagnetic tracking device and compared the results using a general linear mixed model (GLMM) for regression. In the recovery position, the range of motion for lateral bending was 11.9°. While both HAINES positions caused a similar range of motion, the motion caused by the LTP was 2.6° less (P = 0.037). The linear axial range of motion in the recovery position was 13.0 mm. In comparison, the HAINES 1 and 2 positions showed significantly less motion (-5.8 and -4.6 mm, respectively), while the LTP did not (-4.0 mm, P = 0.067). Our results indicate that in unconscious trauma patients, the LTP or one of the two HAINES techniques is preferable to the standard recovery position in cases of an unstable cervical spine injury. © 2016 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

5. Historic American Buildings Survey Nathaniel R. Ewan, Photographer September ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey Nathaniel R. Ewan, Photographer September 8, 1937 INTERIOR - DETAIL OF NUMERALS (1776) ON ENCLOSED END OF ORIGINAL HOUSE - Haines-Budd House, Lumberton, Burlington County, NJ

Haine v. Leves, 7 April 1987.

PubMed

1987-01-01

The Court ruled that where pupils coming from within a local community were segregated into single sex schools with differences in their curricula that resulted in a variation in educational qualification such that the school qualification of boys for tertiary education and employment was greater than that of girls, the Equal Opportunity Tribunal could conclude that the girls were being discriminated against under Section 31A of the Anti-Discrimination Act 1977. full text

Status and Impacts of Arctic Freshwater Export

NASA Astrophysics Data System (ADS)

Haine, T. W. N.

2017-12-01

Large freshwater anomalies clearly exist in the Arctic Ocean. For example, liquid freshwater has accumulated in the Beaufort Gyre in the decade of the 2000s compared to 1980-2000, with an extra ≈5000 km3—about 25%—being stored. The sources of freshwater to the Arctic from precipitation and runoff have increased between these periods (most of the evidence comes from models). Despite flux increases from 2001 to 2011, it is uncertain if the marine freshwater source through Bering Strait for the 2000s has changed, as observations in the 1980s and 1990s are incomplete. The marine freshwater fluxes draining the Arctic through Fram and Davis straits are also insignificantly different. In this way, the balance of sources and sinks of freshwater to the Arctic, Canadian Arctic Archipelago (CAA), and Baffin Bay shifted to about 1200±730 km3yr-1 freshening the region, on average, during the 2000s. The observed accumulation of liquid freshwater is consistent with this increased supply and the loss of freshwater from sea ice (Figure, right). Evidence exists that such discharges can impact the Atlantic meridional overturning circulation, and hence Atlantic sector climate. Nevertheless, it appears that the observed AMOC variability since 2004, when high quality measurements began, is not attributable to anthropogenic influence. This work is based on, and updated from, Haine et al. (2015), Carmack et al. (2016), and Haine (2016). Haine, T. W. N. Ocean science: Vagaries of Atlantic overturning. Nature Geoscience, 9, 479-480, 10.1038/ngeo2748, 2016. T. W. N. Haine et al., Arctic Freshwater Export: Status, Mechanisms, and Prospects, Global Planetary Change, 125, 13-35, 10.1016/j.glopacha.2014.11.013, 2015. E. Carmack et al., Fresh water and its role in the Arctic Marine System: sources, disposition, storage, export, and physical and biogeochemical consequences in the Arctic and global oceans. J. G. Res. Biogeosciences, 10.1002/2015JG003140, 2016.

String test

MedlinePlus

... Management by Laboratory Methods . 23rd ed. Philadelphia, PA: Elsevier; 2017:chap 64. Bope ET, Kellerman RD. The ... ET, ed. Conn's Current Therapy 2016 . Philadelphia, PA: Elsevier; 2016:chap 3. Haines CF, Sears CL. Infectious ...

Giardia infection

MedlinePlus

... eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 283. Haines CF, Sears CL. ... Gastrointestinal and Liver Disease . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 110. Nash TE, Hill DR. ...

Alcoholic liver disease

MedlinePlus

... FF, ed. Ferri's Clinical Advisor 2018 . Philadelphia, PA: Elsevier; 2018:59-60. Carithers RL, McClain C. Alcoholic ... Gastrointestinal and Liver Disease . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 86. Haines EJ, Oyama LC. ...

75 FR 69427 - PPL Holtwood, LLC; Notice of Application for Amendment of License and Soliciting Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... Susquehanna River, in Lancaster and York Counties, Pennsylvania. g. Filed Pursuant to: Federal Power Act, 16 U... a 33.8-acre parcel on which the Indian Steps Museum and Ulmer-Root-Haines Memorial Park and nature...

Shigellosis

MedlinePlus

... Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 340. DuPont HL. Approach to the ... eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 283. Haines CF, Sears CL. ...

CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOS

EPA Science Inventory

CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOs John Haines and Shane Rogers NRMRL Science Questions MYP Science Ouestion: What BMP treatment systems and restoration technologies are most effective options for watershed management? For mixed land use wa...

Recruitment Practices Change, but Issues Remain the Same

ERIC Educational Resources Information Center

Hugo, Esther

2012-01-01

What the author found most surprising about Richard Haines' survey on 1974 recruitment practices was that the major issues are still relevant. His main points about recruitment, college and counselor interaction, and the need for better information still resonate as the profession consistently calls for clarity and transparency in the college…

Advancing Educational Diversity: Antifragility, Standardization, Democracy, and a Multitude of Education Options

ERIC Educational Resources Information Center

Fortunato, Michael W. P.

2017-01-01

This essay is a response to a paper by Avery and Hains that raises questions about the often unintended effects of knowledge standardization in an educational setting. While many K-12 schools are implementing common core standards, and many institutions of higher education are implementing their own standardized educational practices, the question…

75 FR 32096 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

.... The large number of SIAPs, Takeoff Minimums and ODPs, in addition to their complex nature and the need... Rivers, MI, Three Rivers Muni Dr. Haines, NDB RWY 27, Amdt 7A, CANCELLED Brainerd, MN, Brainerd Lakes Rgnl, RNAV (GPS) RWY 5, Amdt 1 Brainerd, MN, Brainerd Lakes Rgnl, RNAV (GPS) RWY 12, Amdt 1 Brainerd...

Update on Longleaf Pine Seed Supply Meeting

Treesearch

Mark J. Hainds

2002-01-01

This is an update of the activities following the September 1999 meeting concerning measures that were discussed to address the longleaf pine seed supply shortage. The people in attendance were Dr. Dean Gjerstad, Mark Haines, Robert Gandy, Larry Bishop, Dr. Ron Carey, Dr. Carey's graduate student Steve Oak, Dr. Jim Barnett, and Jill Barbour

The potential impact of regional climate change on fire weather in the United States

Treesearch

Ying Tang; Shiyuan Zhong; Lifeng Luo; Xindi Bian; Warren E. Heilman; Julie. Winkler

2015-01-01

Climate change is expected to alter the frequency and severity of atmospheric conditions conducive for wildfires. In this study, we assess potential changes in fire weather conditions for the contiguous United States using the Haines Index (HI), a fire weather index that has been employed operationally to detect atmospheric conditions favorable for large and erratic...

Strategies to Support Concentration

ERIC Educational Resources Information Center

Haines, Annette

2017-01-01

Annette Haines provides a comprehensive overview of concentration across the planes. She first lays the foundation for thinking about student engagement: It must be understood that concentration is found through the interest of the child, which is guided by the sensitive periods. When we understand the child's development in this way, we can offer…

Spring Research Festival and NICBR Collaboration Winners Announced | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria

Workforce Education. Hotel and Motel Workers. A Section 353 Demonstration Project.

ERIC Educational Resources Information Center

Polk County Public Schools, Bartow, FL.

This guide provides an overall view of a program designed to educate adult basic education (ABE) and English-as-a-Second-Language (ESL) students in job-related, language-oriented skills vital to their positions in the hotel/motel industry. The program was designed for the employees of Grenelefe Resort and Conference Center in Haines City, Florida,…

76 FR 70053 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-10

... 8260-15A. The large number of SIAPs, Takeoff Minimums and ODPs, in addition to their complex nature and... Three Rivers, MI, Three Rivers Muni Dr. Haines, Takeoff Minimums and Obstacle DP, Orig Brainerd, MN, Brainerd Lakes Rgnl, ILS OR LOC/DME RWY 34, Amdt 1 Park Rapids, MN, Park Rapids Muni-Konshok Field, NDB RWY...

Thirty-One Years of Group Research in "Social Psychology Quarterly" (1975-2005)

ERIC Educational Resources Information Center

Harrod, Wendy J.; Welch, Bridget K.; Kushkowski, Jeff

2009-01-01

We examined trends in group research published in Social Psychology Quarterly (SPQ) from 1975 to 2005. We identified a total of 332 papers about groups published during the time period. Following Moreland, Hogg, and Hains (1994), we created an index of interest in groups by dividing the number of pages in papers about groups by the total number of…

DLA Pre-Award Contracting System

DTIC Science & Technology

1993-05-01

Gulley DPSSO Bldg 33 Standards Cheryl Haines DISC-RMO Bldg 36 Lead Time Jeff Hammer DGSC-P Bldg 32 DPACS WorkloadjersonnedALT Judy Harroson DLA-Z...33 DPACS Functionality Lou JuIg DISC-RM Bldg 36 Resource Data Sandra King DLA-ZSM 3A675 Project Oversight Scotie Knott DGSC-P Bldg 33 Post Award Dave

Why Do You Write? Creative Writing and the Reflective Teacher

ERIC Educational Resources Information Center

Hains-Wesson, Rachael

2013-01-01

In this article, the author asserts that whether we write creatively or academically (or both) it takes time to understand the reasons why we "want" to write, and the more we write, the more we fully begin to appreciate why we have to write in the ?rst place. From an early age, nearly every day, Rachel Hains-Wesson actively participated in…

Numerical Relativistic Quantum Optics

DTIC Science & Technology

2013-11-08

Camilo, V.M. Kaspi, A.G. Lyne, R.N. Manchester, J.F. Bell, N. D’Amico, N.P.F. McKay, 24 and F. Crawford. Discovery of two high magnetic field radio... pulsars . The Astrophysical Journal, 541:367–373, Sep 2000. [15] M. Tatarakis, I. Watts, F.N. Beg, E.L. Clark, A.E. Dangor, A. Gopal, M.G. Haines, P.A

Performance of the Abbott RealTime MTB RIF/INH resistance assay when used to test Mycobacterium tuberculosis specimens from Bangladesh.

PubMed

Kostera, Joshua; Leckie, Gregor; Abravaya, Klara; Wang, Hong

2018-01-01

The Abbott RealTime MTB RIF/INH Resistance Assay (RT MTB RIF/INH) is an assay for the detection of rifampicin (RIF)- and/or isoniazid (INH)-resistant Mycobacterium tuberculosis (MTB). The assay can be used to test sputum, bronchial alveolar lavage, and N-Acetyl-L-Cysteine (NALC)/NaOH pellets prepared from these samples. The assay can be used in direct testing mode, or in reflex mode following a MTB positive result produced by its companion assay, Abbott RT MTB. In this study, the direct testing mode was used to test paired sputum and NALC/NaOH pellets prepared from sputum collected from Bangladesh TB patients. One hundred and thirty two paired samples were tested. The RT MTB RIF/INH inhibition rate was 0%. One hundred and twenty-two paired samples had results above the assay limit of detection and were analyzed by comparing with results from phenotypic drug sensitivity testing, GeneXpert MTB/RIF (Xpert), and MTBDR plus (Hain). RT MTB RIF/INH results were in good agreement with those of GeneXpert and Hain. The ability of this assay to detect RIF and INH resistance may contribute to the global control of multidrug resistant tuberculosis.

ARC-2010-AC00-0168-9-Edit

NASA Image and Video Library

2000-11-03

The Honorable George P. Schultz during a Visit and tour of Ames Research Center. Shown here from left to right are in the background Bill Berry, Ames Deputy Director, Dr. Tom Edwards, Chief, Aviation Systems Division, Front row, Dr. Sidney Drell, Staford University, former U S Secretary of State George Schultz, Dr Richard Haines, Senior Research Csientist, FFC at the Future Flight Central Simulator facility.

Inventory of File nam.t00z.smartconus06.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 6 hour fcst Dew Point Temperature [K] 003 surface SPFH 6 hour fcst Specific Index [K] 027 surface HINDEX 6 hour fcst Haines Index [Numeric] 028 surface TMP 5 hour fcst Temperature [K] 029 surface TMP 4 hour fcst Temperature [K] 030 surface DPT 5 hour fcst Dew Point Temperature [K

Inventory of File nam.t00z.smartak06.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 6 hour fcst Dew Point Temperature [K] 003 surface SPFH 6 hour fcst Specific Haines Index [Numeric] 029 surface TMP 5 hour fcst Temperature [K] 030 surface TMP 4 hour fcst Temperature [K] 031 surface DPT 5 hour fcst Dew Point Temperature [K] 032 surface DPT 4 hour fcst Dew Point

Inventory of File nam.t00z.smartak03.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 3 hour fcst Dew Point Temperature [K] 003 surface SPFH 3 hour fcst Specific fcst Haines Index [Numeric] 026 surface TMP 2 hour fcst Temperature [K] 027 surface TMP 1 hour fcst Temperature [K] 028 surface DPT 2 hour fcst Dew Point Temperature [K] 029 surface DPT 1 hour fcst Dew Point

Inventory of File nam.t00z.smartconus12.tm00.grib2

Science.gov Websites

Temperature [K] 002 surface DPT 12 hour fcst Dew Point Temperature [K] 003 surface SPFH 12 hour fcst Specific hour fcst Haines Index [Numeric] 030 surface TMP 11 hour fcst Temperature [K] 031 surface TMP 10 hour fcst Temperature [K] 032 surface DPT 11 hour fcst Dew Point Temperature [K] 033 surface DPT 10 hour

Appendix A: Vascular Plants of GLEES

Treesearch

J. D. Haines; C .M. Regan

1994-01-01

This appendix provides a list of 230 vascular plant taxa that were field identified and/or collected over the period 1986-1990. Field identification was done by C.L. Simmons in 1986-87 (see Chapter 2). Subsequent taxa were field identified, collected, and verified by J.D. Haines and C.M. Regan in 1988-90. Voucher specimens were verified by taxonomists at the Rocky...

The Tribology of Undulated Surfaces

DTIC Science & Technology

1989-05-30

wear, in effect by decreasing the impact of plowing. Lubrication, hard coatings, fiber-reinforced composites are but a few examples. All these methods ha...In addition, the effects of pad width and cavity volume fraction of the undulated surface were also investigated. A plowing model proposed for...boundary lubricated sliding is in good agreement with experimental results. It is suggested, furthermore, that the undulated surfaces provide an effective

Office of Strategic Services Training during World War II

DTIC Science & Technology

2010-06-01

First Central Intelligence Agency (Berkeley: University of California Press, 1972); Thomas F. Troy, Donovan and the CIA: A History of the...William E. Colby Papers, Box 14, Folder 7, Seeley G. Mudd Library, Princeton University, Princeton, New Jer- sey. 50. Gerald K. Haines, “Virginia...subject heading] 29 January 1945, 2–3, CIA Records (RG 263), Thomas Troy Files, Box 6, Folder 46, National Archives, II. In August 2008, the

A Microwave Method for Measuring Moisture Content, Density, and Grain Angle of Wood.

DTIC Science & Technology

1985-03-01

Livermore, CA 94550. James, William L; Yen , You - Hsin ; King, Ray J. A microwave method for measuring moisture content,density, and grain angle of wood...Note S FPL-0250 March 1985 Density, and Grain 8 Angle of Wood William L. James, Physicist Forest Products Laboratory, Madison, WI You -Hain Yen ... Yen . You -1tsin. Microwave electromagnetic nondestructive testing of wood in real- time. Madison. WI: Department of Electronic and Computer

2002 Industry Analysis Research Paper: Global Environment, Global Industry, and Global Security: Managing the Crossroads

DTIC Science & Technology

2002-01-01

from polluted wells or rivers and wastewater is discharged into ditches or untreated systems that in turn contaminate the drinking water for others who...being embedded into core business lines of many major corporations. The U.N. Conference on Environment and Development, held in Rio de Janeiro , Brazil in...climate change. Capt. Mohd Amdan Kurish, Royal Malaysian Navy Mr. John L. Gerlaugh, OSD Lt Col Thomas J. Hains, USAF. Mr. Kevin E . Holt, USMC Col

Hydrodynamic Flow Control in Marine Mammals

DTIC Science & Technology

2008-05-06

body- bound vorticity ( Wolfgang et al. 1999). The vorticity is smoothly propagated along the flexing body toward the tail. This vorticity is eventually...and Reichley 1985; Dolphin 1988; Pauly et al. 1998). Whales lunge toward their prey at 2.6 m/s (Jurasz and Jurasz 1979; Hain et al. 1982). The...unsteady RANS CFD code for ship hydrodynamics. IIHR Hydroscience and Engineering Report 531. Iowa City (IA): The University of Iowa. Pauly D, Trites

Bioenergetic Defects and Oxidative Damage in Transgenic Mouse Models of Neurodegenerative Disorders

DTIC Science & Technology

2005-06-01

Implications for Lewy body for- mation in Parkinson’s disease and dementia with Lewy bodies. 1. Folk, J. E. 1980 . Transglutaminases. Annu. Rev...Mazziotta, J. C., Pahl, J. J., St George- Hyslop , P., Neurodegen. 5:27-33. Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., and 61. Matsuishi...and isoquinoline and Bright 1980 ). Systemic administration of 3-NP inhibits derivative neurotoxicity was associated with reduced activity SDH in the

Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards from FY 1988 SBIR Solicitation

DTIC Science & Technology

1989-05-01

FORMULATION -- FLOQUET-GALERKIN. DELPHI RESEARCH INC 701 HAINES AVE NW ALBUQUERQUE, NM 87102 CONTRACT NUMBER: PATRICK M DHOOGE TITLE: RESEARCH ON A...MEASURE THE DIELECTRIC RESPONSE OF A DIAMOND FILM AS IT GROWNS. DIESEL DYNE CORP 3044 MIDDLEBORO RD MORROW, OH 45152 CONTRACT NUMBER: RICHARD P JOHNSTON...TITLE: A STUDY OF AN ADVANCED VARIABLE CYCLE DIESEL ENGINE FOR USE IN A REMOTELY PILOTED VEHICLE TOPIC# 18 OFFICE: ASTO IDENT#: 22796 THIS STUDY IS

Low Voltage Electron Beam Lithography

DTIC Science & Technology

1994-01-01

September 1970 (Societe Franaise do Microscopic Elecuouique, Plaris, 1970) Vol. 2, p. 55. [31 H . C. Pfeiffer, "Basic limitations of probefonning systems...USA (editors: 0. Jobari and I. Corvin). [4) T. Groves, D. L Hunmond, H . Kuo, ’Elecmnm-beam broadening effct caused by discreteness of space charge...Electron Microscope Gun". Br. J. Appi. Phys.. February 1952, pp. 40-46. M. E. Haine, P. A. Einstein, and P. H . Brocherd. "Resistance Bias

Meteorological Error Budget Using Open Source Data

DTIC Science & Technology

2016-09-01

ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using Open- Source Data by J Cogan, J Smith, P...needed. Do not return it to the originator. ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using...Error Budget Using Open-Source Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) J Cogan, J Smith, P Haines

Puget Sound Dredged Disposal Analysis (PSDDA). Final Environmental Impact Statement Unconfined Open-Water Disposal for Dredged Material, Phase 2. (North and South Puget Sound)

DTIC Science & Technology

1989-09-01

flathead sole, rex sole, and rock sole all showed indications of blood worm infestations. One liver tumor was found in a rex sole during spring in the ZSF...concentrations Hainly in invertebrates; some trations (.01 ppb) in waters (from lOx to 42Ox reference) in fish livers ; rarely in fish of Puget Sound central...Eagle Harbor, and Sinclair fish livers , and birds in Inlet. Highest elevation industrialized ’-ban areas. along Ruston-Point Defiance Copper is a natural

Bioenergetic Defects and Oxidative Damage in Transgenic Mouse Models of Neurodegenerative Disorders

DTIC Science & Technology

2004-05-01

Grafton, S. T., Mazziotta, J. C., Pahl, J. J., St George- Hyslop , P., Neurodegen. 5:27-33. Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., and 61...another TCA enzyme (Porter Previous studies showed that MPTP and isoquinoline and Bright 1980 ). Systemic administration of 3-NP inhibits derivative...Brouillet E., Ferrante R., Palfi S., Dolan R., Matthews R. T. Porter D. J. T. and Bright H. J. ( 1980 ) 3-Carbanionic substrate analogues and Beal M. F

Spring Research Festival and NICBR Collaboration Winners Announced | Poster

Cancer.gov

By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria Kaltcheva, Wojciech Kasprzak, Balamurugan Kuppusamy, James Lautenberger, George Lountos, Megan Mounts, Uma Mudunuri, Martha Sklavos, Gloriana Shelton, Alex Sorum, and Shea Wright.

Immunotherapeutic Strategies in Breast Cancer:Preclinical and Clinical Trials

DTIC Science & Technology

2012-09-01

in enhanced CTL responses with anti-tumor activity. Journal of Immunology. 2000;165:539-47. 24. Haining WN, Davies J, Kanzler H, Drury L, Brenn T...including pancreatic cancer that express MUCl accounted for about 72% of new cases and for 66% of the deaths [ 1]. These observations have prompted...December 12, 2002. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby

Analytical and clinical performance characteristics of the Abbott RealTime MTB RIF/INH Resistance, an assay for the detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis in pulmonary specimens.

PubMed

Kostera, Joshua; Leckie, Gregor; Tang, Ning; Lampinen, John; Szostak, Magdalena; Abravaya, Klara; Wang, Hong

2016-12-01

Clinical management of drug-resistant tuberculosis patients continues to present significant challenges to global health. To tackle these challenges, the Abbott RealTime MTB RIF/INH Resistance assay was developed to accelerate the diagnosis of rifampicin and/or isoniazid resistant tuberculosis to within a day. This article summarizes the performance of the Abbott RealTime MTB RIF/INH Resistance assay; including reliability, analytical sensitivity, and clinical sensitivity/specificity as compared to Cepheid GeneXpert MTB/RIF version 1.0 and Hain MTBDRplus version 2.0. The limit of detection (LOD) of the Abbott RealTime MTB RIF/INH Resistance assay was determined to be 32 colony forming units/milliliter (cfu/mL) using the Mycobacterium tuberculosis (MTB) strain H37Rv cell line. For rifampicin resistance detection, the Abbott RealTime MTB RIF/INH Resistance assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Cepheid GeneXpert MTB/RIF. For isoniazid resistance detection, the assay demonstrated statistically equivalent clinical sensitivity and specificity as compared to Hain MTBDRplus. The performance data presented herein demonstrate that the Abbott RealTime MTB RIF/INH Resistance assay is a sensitive, robust, and reliable test for realtime simultaneous detection of first line anti-tuberculosis antibiotics rifampicin and isoniazid in patient specimens. Copyright © 2016 The Author. Published by Elsevier Ltd.. All rights reserved.

Evaluation of groundwater discharge into small lakes based on the temporal distribution of radon-222

USGS Publications Warehouse

Dimova, N.T.; Burnett, W.C.

2011-01-01

In order to evaluate groundwater discharge into small lakes we constructed a model that is based on the budget of 222Rn (radon t1/2 5 3.8 d) as a tracer. The main assumptions in our model are that the lake's waters are wellmixed horizontally and vertically; the only significant 222Rn source is via groundwater discharge; and the only losses are due to decay and atmospheric evasion. In order to evaluate the groundwater-derived 222Rn flux, we monitored the 222Rn concentration in lake water over periods long enough (usually 1-3 d) to observe changes likely caused by variations in atmospheric exchange (primarily a function of wind speed and temperature). We then attempt to reproduce the observed record by accounting for decay and atmospheric losses and by estimating the total 222Rn input flux using an iterative approach. Our methodology was tested in two lakes in central Florida: one of which is thought to have significant groundwater inputs (Lake Haines) and another that is known not to have any groundwater inflows but requires daily groundwater augmentation from a deep aquifer (Round Lake). Model results were consistent with independent seepage meter data at both Lake Haines (positive seepage of ??? 1.6 ?? 104 m3 d-1 in Mar 2008) and at Round Lake (no net groundwater seepage). ?? 2011, by the American Society of Limnology and Oceanography, Inc.

Sliding Charge Density Waves and Related Problems.

DTIC Science & Technology

1987-03-31

mecan -field ihcorn, with r-I oI. Lcntcr,, M ith inlinite-ranve interactions, the distinction Niet the exponential divergence follow4ed hv saturation...or the incommensu- liv simuiating Eq. (2) in systems up to 377 particles in rate chain. si/c ve were -ible to restrict tinite-size eflects to the... up another qualitative difference between 0 nc twko ,cis of theoretical results: While the incommensu- 0 20 40 60 80 100 120 140 _.:e :hain. like the

Novel Heterongineered Detectors for Multi-Color Infrared Sensing

DTIC Science & Technology

2012-01-30

barriers”. Appl. Phys. Lett. 98, 121106 (2011) 9. A. Khoshakhlagh, F. Jaeckel C. Hains J. B. Rodriguez , L. R. Dawson, K. Malloy, and S. Krishna...AlAs etch-stop layer. The detailed processing sequence is included in the Methods. b da c n + -GaAs 200 nm Mesa lndium bump 2.1 –2.1 FPA p d SP-FPA...FPA chip. The processing scheme of the plasmonic FPA chip consists of a dry etch to form the mesa , surface passivation, ohmic metal evaporation, under

Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel

NASA Technical Reports Server (NTRS)

Coder, D. W.

1984-01-01

Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.

Examining Atmospheric and Ecological Drivers of Wildfires, Modeling Wildfire Occurrence in the Southwest United States, and Using Atmospheric Sounding Observations to Verify National Weather Service Spot Forecasts

NASA Astrophysics Data System (ADS)

Nauslar, Nicholas J.

This dissertation is comprised of three different papers that all pertain to wildland fire applications. The first paper performs a verification analysis on mixing height, transport winds, and Haines Index from National Weather Service spot forecasts across the United States. The final two papers, which are closely related, examine atmospheric and ecological drivers of wildfire for the Southwest Area (SWA) (Arizona, New Mexico, west Texas, and Oklahoma panhandle) to better equip operational fire meteorologists and managers to make informed decisions on wildfire potential in this region. The verification analysis here utilizes NWS spot forecasts of mixing height, transport winds and Haines Index from 2009-2013 issued for a location within 50 km of an upper sounding location and valid for the day of the fire event. Mixing height was calculated from the 0000 UTC sounding via the Stull, Holzworth, and Richardson methods. Transport wind speeds were determined by averaging the wind speed through the boundary layer as determined by the three mixing height methods from the 0000 UTC sounding. Haines Index was calculated at low, mid, and high elevation based on the elevation of the sounding and spot forecast locations. Mixing height forecasts exhibited large mean absolute errors and biased towards over forecasting. Forecasts of transport wind speeds and Haines Index outperformed mixing height forecasts with smaller errors relative to their respective means. The rainfall and lightning associated with the North American Monsoon (NAM) can vary greatly intra- and inter-annually and has a large impact on wildfire activity across the SWA by igniting or suppressing wildfires. NAM onset thresholds and subsequent dates are determined for the SWA and each Predictive Service Area (PSA), which are sub-regions used by operational fire meteorologists to predict wildfire potential within the SWA, April through September from 1995-2013. Various wildfire activity thresholds using the number

Micro-PIV measurements of multiphase flow of water and liquid CO2 in 2-D heterogeneous porous micromodels

NASA Astrophysics Data System (ADS)

Li, Yaofa; Kazemifar, Farzan; Blois, Gianluca; Christensen, Kenneth T.

2017-07-01

We present an experimental study of pore-scale flow dynamics of liquid CO2 and water in a two-dimensional heterogeneous porous micromodel, inspired by the structure of a reservoir rock, at reservoir-relevant conditions (80 bar, 21°C). The entire process of CO2 infiltration into a water-saturated micromodel was captured using fluorescence microscopy and the micro-PIV method, which together reveal complex fluid displacement patterns and abrupt changes in velocity. The CO2 front migrated through the resident water in an intermittent manner, forming dendritic structures, termed fingers, in directions along, normal to, and even opposing the bulk pressure gradient. Such characteristics indicate the dominance of capillary fingering through the micromodel. Velocity burst events, termed Haines jumps, were also captured in the heterogeneous micromodel, during which the local Reynolds number was estimated to be ˜21 in the CO2 phase, exceeding the range of validity of Darcy's law. Furthermore, these drainage events were observed to be cooperative (i.e., across multiple pores simultaneously), with the zone of influence of such events extending beyond tens of pores, confirming, in a quantitative manner, that Haines jumps are nonlocal phenomena. After CO2 completely breaks through the porous section, shear-induced circulations caused by flowing CO2 were also observed, in agreement with previous studies using a homogeneous porous micromodel. To our knowledge, this study is the first quantitative measurement that incorporates both reservoir-relevant conditions and rock-inspired heterogeneity, and thus will be useful for pore-scale model development and validation.

Rational Ruijsenaars Schneider hierarchy and bispectral difference operators

NASA Astrophysics Data System (ADS)

Iliev, Plamen

2007-05-01

We show that a monic polynomial in a discrete variable n, with coefficients depending on time variables t1,t2,…, is a τ-function for the discrete Kadomtsev-Petviashvili hierarchy if and only if the motion of its zeros is governed by a hierarchy of Ruijsenaars-Schneider systems. These τ-functions were considered in [L. Haine, P. Iliev, Commutative rings of difference operators and an adelic flag manifold, Int. Math. Res. Not. 2000 (6) (2000) 281-323], where it was proved that they parametrize rank one solutions to a difference-differential version of the bispectral problem.

Applications of Artificial Intelligence in Voice Recognition Systems in Micro-Computers.

DTIC Science & Technology

1982-03-01

DELTAO THEN 1290 1050 IF ANS$(I) = "HAIN MENU THEN 320 1060 IF ANS$(I) - " ABORTO THEN 3150 1070 IF ANS$(I) - 󈧄 BACK’ THEN 3590 1080 NEXT I 1090... ABORTO THEN 3150 1660 NEXT I 1670 SOTO 3350 3 REM’ ERROR PACK 1680 STOP 1690 REM SHIPS MENU 1700 REM------------ 1710 HOME : VTAB 5 :HTAB 15 :PRINT...IF ANS*(I) - PROFILESO THEN 3100 2470 IF IS$(I) - "MIN MENU" THEN 320 24Sf IF NB$(I) - "G0 BACK" THEN 3590 2490 IF ANS$(I) - " ABORTO THEN 3150 2500

Screening a library of household substances for inhibitors of phosphatases: An introduction to high-throughput screening.

PubMed

Taylor, Ann T S

2005-01-01

Library screening methods are commonly used in industry and research. This article describes an experiment that screens a library of household substances for properties that would make a good "drug," including enzyme inhibition, neutral pH, and nondenaturing to proteins, using wheat germ acid phosphatase as the target protein. An adaptation of the experiment appropriate for lower level biochemistry or outreach is also described. This work was supported by Wabash College through the Haines Fund for the Study of Biochemistry and the National Science Foundation through Grant DUE 0126242. Copyright © 2005 International Union of Biochemistry and Molecular Biology, Inc.

Combining turbulent kinetic energy and Haines Index predictions for fire-weather assessments

Treesearch

Warren E. Heilman; Xindi Bian

2007-01-01

The 24- to 72-hour fire-weather predictions for different regions of the United States are now readily available from the regional Fire Consortia for Advanced Modeling of Meteorology and Smoke (FCAMMS) that were established as part of the U.S. National Fire Plan. These predictions are based on daily real-time MM5 model simulations of atmospheric conditions and fire-...

PCR identification of bacteria in blood culture does not fit the daily workflow of a routine microbiology laboratory.

PubMed

Karumaa, Santra; Kärpänoja, Pauliina; Sarkkinen, Hannu

2012-03-01

We have evaluated the GenoType blood culture assay (Hain Lifescience, Nehren, Germany) for the identification of bacteria in 233 positive blood cultures and assessed its suitability in the workflow of a routine microbiology laboratory. In 68/233 (29.2%) samples, the culture result could not be confirmed by the GenoType assay due to a lack of primers in the test, multiple organisms in the sample, or inconsistency with respect to the identification by culture. Although the GenoType blood culture assay gives satisfactory results for bacteria for which primers are available, there are difficulties in applying the test in the routine microbiology laboratory.

Dusting off another shelf: further comments on classic gynecologic pathology books of yesteryear.

PubMed

Young, Robert H

2005-01-01

Selected outstanding books from the older literature on gynecologic pathology are reviewed with emphasis on drawing attention to the abundant helpful information and often outstanding illustrations that are worthy of review by present-day pathologists. This represents a follow up to a previous similar essay that appeared in Volume 19:67-84, 2000. The first three books cover general gynecological pathology: Gynecological Pathology by Carl Abel; Gynecological and Obstetrical Pathology by Robert T. Frank; and Haines and Taylor's Gynaecological Pathology by Magnus Haines and Claud W. Taylor. Each of them emphasizes the time-honored problem of mimicry of malignancy by diverse benign lesions or even aspects of normal histology. Awareness of the clinical background and cooperation between the clinician and pathologist are emphasized. The other three books considered are all devoted largely or exclusively to the ovary: Ovarian Tumors by Hans Selye, Ovarian Neoplasms, Morphology, and Classification by Karel Motlik, and Special Tumors of Ovary and Testis and Related Extragonadal Lesions by Gunnar Teilum. The book of Selye has a truly remarkable encyclopedic coverage of the older literature, the references being so comprehensive that they are presented in a separate volume. A number of aspects of the histopathology of ovarian tumors that have been emphasized in recent years are noted in Selye's book. Dr. Motlik's book presents a very high quality consideration of the differential diagnosis of ovarian tumors. Teilum's book contains a masterful account of the histopathology of germ cell tumors emphasizing a neoplasm with which his name will always be associated, the yolk sac tumor (endodermal sinus tumor). Numerous beautiful and refreshingly large illustrations are provided, and Dr. Teilum's interest in comparative pathology is evident in the pages, his linking of the famous Schiller-Duval bodies with the endodermal sinuses of the rat placenta, being the most notable example.

Post-polio syndrome. Cases report and review of literature.

PubMed

Pastuszak, Żanna; Stępień, Adam; Tomczykiewicz, Kazimierz; Piusińska-Macoch, Renata; Galbarczyk, Dariusz; Rolewska, Agnieszka

It is estimated that around 15 million people survived polio infection worldwide since early twentieth century. In 1950 effective vaccination was used for first time. Since that time number of affected people decreased. The last epidemic of Haine-Medine disease in Poland was in 1950s. Another rare cases of infections were observed till 1970s. About at least 15 years after polio virus infection, slowly progressive muscle limbs paresis with muscle atrophy, joints pain, paresthesia were observed in polio survivors. That constellation of symptoms was called post-polio syndrome (PPS). PPS frequency among people after paralytic and nonparalytic polio infectious is ranged from 30% to 80%. Fatigue that leads to physical and mental activity deterioration is another important symptom that is observed in 90% of patients with PPS. Etiology of disease remains elusive. Probably it is an effect of spine frontal horns motoneurons damage during acute virus polio infection that leads to overloading and degeneration of remaining ones. The most important risk factors of PPS are female sex and respiratory symptoms during acute polio infection. Electromyography is an important part of PPS diagnostic process. Electrophysiological abnormalities are seen in clinically affected and unaffected muscles. The most frequent are fasciculations and fibrillations during rest activity, extension of motor unit area, time duration and amplitude. In this study we described three cases of people who developed PPS years after Haine-Medine disease and correlation between their EMG results and clinical status. We also analyzed electromyography results both after one month since first PPS signs occurred as well as after few years. Presentation of dynamic changes in EMG was the most important aim of that study. Copyright © 2017. Published by Elsevier Urban & Partner Sp. z o.o.

Human performance measurement: Validation procedures applicable to advanced manned telescience systems

NASA Technical Reports Server (NTRS)

Haines, Richard F.

1990-01-01

As telescience systems become more and more complex, autonomous, and opaque to their operators it becomes increasingly difficult to determine whether the total system is performing as it should. Some of the complex and interrelated human performance measurement issues are addressed as they relate to total system validation. The assumption is made that human interaction with the automated system will be required well into the Space Station Freedom era. Candidate human performance measurement-validation techniques are discussed for selected ground-to-space-to-ground and space-to-space situations. Most of these measures may be used in conjunction with an information throughput model presented elsewhere (Haines, 1990). Teleoperations, teleanalysis, teleplanning, teledesign, and teledocumentation are considered, as are selected illustrative examples of space related telescience activities.

Legionnaires disease presenting as acute kidney injury in the absence of pneumonia.

PubMed

Yogarajah, Meera; Sivasambu, Bhradeev

2015-02-17

Legionnaires disease is a pneumonic illness with multisystem involvement. In 1987, Haines et al reported the only reported case of isolated renal disease of legionellosis without concurrent respiratory disease. A 62-year-old man presented with generalised weakness and malaise and watery diarrhoea, and was found to have acute kidney injury on admission. He was initially managed as acute gastroenteritis complicated with dehydration and acute kidney injury with intravenous hydration. Despite adequate hydration, his renal function was worsening day by day. Later in the course of his sickness he developed pneumonic illness and was diagnosed with Legionnaires disease after a positive urine antigen test. We are reporting the second case of Legionnaires disease presenting as an isolated acute kidney injury in the absence of respiratory symptoms on presentation. 2015 BMJ Publishing Group Ltd.

78 FR 19431 - Safety Zones; Annual Independence Day Fireworks Displays, Skagway, Haines, and Wrangell, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... combination of a large number of spectators, congested waterways, darkness punctuated by bright flashes of... be of short duration, approximately three hours. Furthermore, vessels may be authorized to transit...

78 FR 38200 - Safety Zones; Annual Independence Day Fireworks Displays, Skagway, Haines, and Wrangell, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

..., darkness punctuated by bright flashes of light, and burning debris has the potential to result in serious... enforcement of these safety zones will be of short duration, approximately three hours. Furthermore, vessels...

Tyrosinase Inhibitory Activities of Carissa opaca Stapf ex Haines Roots Extracts and Their Phytochemical Analysis

PubMed Central

Malik, Wajeeha; Ahmed, Dildar; Izhar, Sania

2017-01-01

Objective: Carissa opaca is a medicinal plant with rich folkloric applications. The present research was conducted to explore the tyrosinase inhibitory potential of aqueous decoction (AD) and methanolic extract (ME) of roots of C. opaca and its fractions in various solvents and their phytochemical analysis. Materials and Methods: AD of the dried powdered roots of C. opaca was prepared by boiling in water. ME was prepared by cold maceration. Its fractions were obtained in solvents of increasing polarity, i.e., hexane, chloroform, ethyl acetate, n-butanol, and water. The biomass left after extraction with methanol was boiled in water to get its decoction Biomass aqueous decoction (BAD). Tyrosinase inhibitory activities of the samples were studied according to a reported method. Chemical compounds in the samples were identified by gas chromatography-mass spectrometry (GC-MS). Results: The AD, BAD, and ME and its fractions displayed remarkable tyrosinase inhibitory activity. The IC50 of AD was 23.33 μg/mL as compared to 15.80 μg/mL of the standard arbutin and that of BAD was 21.24 μg/mL. The IC50 of ME was 34.76 μg/mL while that of hexane, chloroform, ethyl acetate, n-butanolic, and aqueous fractions was 21.0, 44.73, 43.40, 27.66, and 25.06 μg/mL, respectively. The hexane fraction was thus most potent followed by aqueous fraction. By phytochemical analysis, campesterol, stigmasterol, gamma-sitosterol, alpha-amyrin, 9,19-cyclolanostan-3-ol, 24-methylene-,(3 β)-, lupeol, lup-20(29)-en-3-one, lup-20(29)-en-3-ol, acetate,(3 β)-, 2(1H) naphthalenone, 3,5,6,7,8,8a-hexahydro-4,8a-dimethyl-6-(1-methylethenyl)-, and 2,3,3-trimethyl-2-(3-methylbuta-1,3-dienyl)-6-methylenecyclohexanone were identified in the extracts by GC-MS. Other compounds included fatty acids and their esters. Some of these compounds are being first time reported here from this plant. Conclusions: The roots extracts exhibited considerable tyrosinase inhibitory activities, alluding to a possible application of the plant in cosmetic as whitening agent subject to further pharmacological studies. SUMMARY The present study aimed to explore the tyrosinase inhibitory potential of aqueous decoction and methanolic extract of roots of Carissa opaca and its fractions in various solvents and their phytochemical constituents. GCMS analysis was conducted to identify the phytochemicals. The extracts and fractions of C. opaca roots showed remarkable anti-tyrosinase activities alluding to their possible application to treat disorders related to overproduction of melanin. Abbreviations used: AD: Aqueous decoction; ME: Methanolic extract; BAD: Biomass aqueous decoction; GC-MS: Gas chromatography-mass spectrometry. PMID:29142412

Effects of Near-Surface Atmospheric Stability and Moisture on Wildfire Behavior and Consequences for Haines Index

Treesearch

Ruiyu Sun; Mary Ann Jenkins

2003-01-01

Since the 1950s, extensive research has been conducted to investigate the relationship between near-surface atmospheric conditions and large wildfire growth and occurrence. Observational studies have demonstrated that near-surface dryness (e-g., Fahnestock 1965) and atmospheric instability (e-g., Brotak and Reifsnyder 1977) are correlated with large wildfire growth and...

Comparison of the socio-demographic and clinical features of pulmonary TB patients infected with sub-lineages within the W-Beijing and non-Beijing Mycobacterium tuberculosis.

PubMed

Hu, Yi; Mathema, Barun; Zhao, Qi; Zheng, Xubin; Li, Dange; Jiang, Weili; Wang, Weibing; Xu, Biao

2016-03-01

Highly lethal outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are increasing. Mycobacterium tuberculosis variant Beijing family and its members is regarded as a successful clone of M. tuberculosis that is associated with drug resistance in China. Understanding the genetic characteristics and molecular mechanism of drug resistant tuberculosis within Beijing family may help to clarify its origin and evolutionary history and the driving forces behind its emergence and current dissemination. Totally of 1222 Mycobacterium tuberculosis isolates were recovered from patients in six counties of two provinces in eastern China within 2010/2012. Strain lineage and its major subgroups were studied respectively by using Spoligotyping and MIRU-VNTR. The 1st-line drug susceptibility was analyzed by proportional method and 2nd-line drug susceptibility was determined by the HAINs MTBDRsl test. The genetic characterization of drug resistance was analyzed by sequencing the previously reported genes and loci associated with drug resistance together with the multiple genotyping including MIRU-VNTR, Spoligotyping and LSP genotyping. Of the 1222 Mtb isolates, 298 (24.4%) were resistant to 1st-line drug and 73 (5.9%) were simultaneously resistant to INH and RIF namely MDR-TB. Respectively 23.8% of 1st-line drug resistant TB and 12.0% of the drug susceptible TB contained the mutation associated with 2nd-line drugs by HAINs test. The Spoligotyping of 1222 Mtb isolates revealed the 967 (79.1%) of the isolates belonged to the W-Beijing family. Within W-Beijing family, 78.8% MDR-TB were observed in the isolates with simultaneous deletion of RD105 and RD207, with sub-lineage 181 accounting for 75% of MDR-TB. Analysis of 24 MIRU-VNTR loci revealed that 88.2% (15/17) of MDR and extensively drug resistant (XDR) clustered isolates were sub-lineage 181. Sublineage 181 might have the capacity to spread throughout the general community in rural China. This is

Pyroconvection Risk in Australia: Climatological Changes in Atmospheric Stability and Surface Fire Weather Conditions

NASA Astrophysics Data System (ADS)

Dowdy, Andrew J.; Pepler, Acacia

2018-02-01

Extreme wildfires with strong convective processes in their plumes have recently led to disastrous impacts on various regions of the world. The Continuous Haines index (CH) is used in Australia to represent vertical atmospheric stability and humidity measures relating to pyroconvective processes. CH climatology is examined here using reanalysis data from 1979 to 2016, revealing large spatial and seasonal variations throughout Australia. Various measures of severity are investigated, including regionally specific thresholds. CH is combined with near-surface fire weather conditions, as a type of compound event, and is examined in relation to environmental conditions associated with pyroconvection. Significant long-term changes in CH are found for some regions and seasons, with these changes corresponding to changes in near-surface conditions in some cases. In particular, an increased risk of pyroconvection is identified for southeast Australia during spring and summer, due to decreased vertical atmospheric stability and humidity combined with more severe near-surface conditions.

Studies of aerothermal loads generated in regions of shock/shock interaction in hypersonic flow

NASA Technical Reports Server (NTRS)

Holden, Michael S.; Moselle, John R.; Lee, Jinho

1991-01-01

Experimental studies were conducted to examine the aerothermal characteristics of shock/shock/boundary layer interaction regions generated by single and multiple incident shocks. The presented experimental studies were conducted over a Mach number range from 6 to 19 for a range of Reynolds numbers to obtain both laminar and turbulent interaction regions. Detailed heat transfer and pressure measurements were made for a range of interaction types and incident shock strengths over a transverse cylinder, with emphasis on the 3 and 4 type interaction regions. The measurements were compared with the simple Edney, Keyes, and Hains models for a range of interaction configurations and freestream conditions. The complex flowfields and aerothermal loads generated by multiple-shock impingement, while not generating as large peak loads, provide important test cases for code prediction. The detailed heat transfer and pressure measurements proved a good basis for evaluating the accuracy of simple prediction methods and detailed numerical solutions for laminar and transitional regions or shock/shock interactions.

Advancing educational diversity: antifragility, standardization, democracy, and a multitude of education options

NASA Astrophysics Data System (ADS)

Fortunato, Michael W. P.

2017-03-01

This essay is a response to a paper by Avery and Hains that raises questions about the often unintended effects of knowledge standardization in an educational setting. While many K-12 schools are implementing common core standards, and many institutions of higher education are implementing their own standardized educational practices, the question is raised about what is lost in this effort to ensure regularity and consistency in educational outcomes. One such casualty may be local knowledge, which in a rural context includes ancestral knowledge about land, society, and cultural meaning. This essay explores whether or not efforts to standardize crowd out such knowledge, and decrease the diversity of knowledge within our society's complex ecosystem—thus making the ecosystem weaker. Using antifragility as a useful idea for examining system complexity, the essay considers the impact of standardization on innovation, democracy, and the valuation of some forms of knowledge (and its bearers) above others.

Towards seasonal Arctic shipping route predictions

NASA Astrophysics Data System (ADS)

Haines, K.; Melia, N.; Hawkins, E.; Day, J. J.

2017-12-01

should become a key component of the future Arctic observing system. Melia, N., K. Haines, and E. Hawkins (2016), Sea ice decline and 21st century trans-Arctic shipping routes, Geophys. Res. Lett., doi:10.1002/ 2016GL069315. Melia, N., K. Haines, E. Hawkins and J.J. Day, 2017, Towards seasonal Arctic shipping route predictions. Env. Res. Lett., doi:10.1088/1748-9326/aa7a60

Tourism and its effects on southeast Alaska communities and resources: case studies from Haines, Craig, and Hoonah, Alaska.

Treesearch

Lee K. Cerveny

2005-01-01

Tourism has become integral to southeast Alaska’s regional economy and has resulted in changes to the social and cultural fabric of community life as well as to natural resources used by Alaskans. This study incorporates an ethnographic approach to trace tourism development in three rural southeast Alaska communities featuring different levels and types of tourism. In...

Pore-scale modeling of phase change in porous media

NASA Astrophysics Data System (ADS)

Juanes, Ruben; Cueto-Felgueroso, Luis; Fu, Xiaojing

2017-11-01

One of the main open challenges in pore-scale modeling is the direct simulation of flows involving multicomponent mixtures with complex phase behavior. Reservoir fluid mixtures are often described through cubic equations of state, which makes diffuse interface, or phase field theories, particularly appealing as a modeling framework. What is still unclear is whether equation-of-state-driven diffuse-interface models can adequately describe processes where surface tension and wetting phenomena play an important role. Here we present a diffuse interface model of single-component, two-phase flow (a van der Waals fluid) in a porous medium under different wetting conditions. We propose a simplified Darcy-Korteweg model that is appropriate to describe flow in a Hele-Shaw cell or a micromodel, with a gap-averaged velocity. We study the ability of the diffuse-interface model to capture capillary pressure and the dynamics of vaporization/condensation fronts, and show that the model reproduces pressure fluctuations that emerge from abrupt interface displacements (Haines jumps) and from the break-up of wetting films.

Biscrolling nanotube sheets and functional guests into yarns

NASA Astrophysics Data System (ADS)

Baughman, Ray

2011-03-01

Multifunctional applications of textiles have been limited by the inability to spin important materials into yarns. Generically applicable methods are demonstrated for producing weavable yarns comprising up to 95 wt % of otherwise unspinnable particulate or nanofiber powders that remain highly functional. Scrolled 50 nm thick carbon nanotube sheets confine these powders in the galleries of irregular scroll sacks, whose observed complex structures are related to twist-dependent extension of Archimedean spirals, Fermat spirals, or spiral pairs into scrolls. The strength and electronic connectivity of a small weight fraction of scrolled carbon nanotube sheet enables yarn weaving, sewing, knotting, braiding, and charge collection. This technology is used to make yarns of superconductors, Li-ion battery materials, graphene ribbons, catalytic nanofibers for fuel cells, and Ti O2 for photocatalysis. Work done in collaboration with Shaoli Fang, Xavier Lepro-Chavez, Chihye Lewis, Raquel Ovalle-Robles, Javier Carratero-Gonzalez, Elisabet Castillo-Martinez, Mikhail Kozlov, Jiyoung Oh, Neema Rawat, Carter Haines, Mohammed Haque, Vaishnavi Aare, Stephanie Stoughton, Anvar Zakhidov, and Ray Baughman, The University of Texas at Dallas / Alan G. MacDiarmid NanoTech Institute.

GOCE User Toolbox and Tutorial

NASA Astrophysics Data System (ADS)

Knudsen, P.; Benveniste, J.

2011-07-01

The GOCE User Toolbox GUT is a compilation of tools for the utilisation and analysis of GOCE Level 2 products. GUT support applications in Geodesy, Oceanography and Solid Earth Physics. The GUT Tutorial provides information and guidance in how to use the toolbox for a variety of applications. GUT consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made available as well. GUT has been developed in a collaboration within the GUT Core Group. The GUT Core Group: S. Dinardo, D. Serpe, B.M. Lucas, R. Floberghagen, A. Horvath (ESA), O. Andersen, M. Herceg (DTU), M.-H. Rio, S. Mulet, G. Larnicol (CLS), J. Johannessen, L.Bertino (NERSC), H. Snaith, P. Challenor (NOC), K. Haines, D. Bretherton (NCEO), C. Hughes (POL), R.J. Bingham (NU), G. Balmino, S. Niemeijer, I. Price, L. Cornejo (S&T), M. Diament, I Panet (IPGP), C.C. Tscherning (KU), D. Stammer, F. Siegismund (UH), T. Gruber (TUM),

New Insights on co-seismic landslide clustering

NASA Astrophysics Data System (ADS)

Meunier, Patrick; Marc, Odin; Hovius, Niels

2015-04-01

Earthquake-triggered landslides tend to cluster along topographic crests while rainfall-induced landslides should occur downslope preferentially, where pore pressure induced by groundwater flows is the highest [1]. Past studies on landslide clustering are all based on the analysis of complete dataset or subdataset of landslides associated with a given event (seismic or climatic) as a whole. In this work, we document the spatial and temporal variations of the landslide position (on hillslopes) within the epicentral area of the 1994 Northridge, the 1999 Chichi, the 2004 Niigata, the 2008 Iwate and the 2008 Wenchuan earthquakes. We show that crest clustering is not systematic, non uniform in space and exhibit patterns that vary a lot from one case to another. These patterns are not easy to interpret as they don't seem to be controlled by a single governing parameter but result from a complex interaction between local (hillslope length and gradient, lithology) and seismic (distance to source, slope aspect, radiation pattern, coseismic uplift) parameters. [1] Meunier, P., Hovius, N., & Haines, J. A. (2008). Topographic site effects and the location of earthquake induced landslides. Earth and Planetary Science Letters, 275(3), 221-232

Into the complexity of coseismic landslide clustering

NASA Astrophysics Data System (ADS)

Meunier, Patrick; Marc, Odin; Uchida, Taro; Hovius, Niels

2014-05-01

Earthquake-triggered landslides tend to cluster along topographic crests while rainfall-induced landslides are more uniformly distributed on hillslopes [1]. In theory, rainfall induced landslides should even occur downslope preferentially, where pore pressure induced by groundwater flows is the highest. Past studies on landslide clustering are all based on the analysis of complete dataset or subdataset of landslides associated with a given event (seismic or climatic) as a whole. In this work, we document the spatial variation of the landslide position (on hillslopes) within the epicentral area for the cases of the 1999 Chichi, the 2004 Niigata and the 2008 Iwate earthquakes. We show that landslide clustering is not uniform in space and exhibit patterns that vary a lot from one case to another. These patterns are not easy to interpret as they don't seem to be controlled by a single governing parameter but result from a complex interaction between local (hillslope length and gradient, lithology) and seismic (distance to source, slope aspect, radiation pattern, coseismic uplift) parameters. [1] Meunier, P., Hovius, N., & Haines, J. A. (2008). Topographic site effects and the location of earthquake induced landslides. Earth and Planetary Science Letters, 275(3), 221-232.

Temperature Data Assimilation with Salinity Corrections: Validation for the NSIPP Ocean Data Assimilation System in the Tropical Pacific Ocean, 1993-1998

NASA Technical Reports Server (NTRS)

Troccoli, Alberto; Rienecker, Michele M.; Keppenne, Christian L.; Johnson, Gregory C.

2003-01-01

The NASA Seasonal-to-Interannual Prediction Project (NSIPP) has developed an Ocean data assimilation system to initialize the quasi-isopycnal ocean model used in our experimental coupled-model forecast system. Initial tests of the system have focused on the assimilation of temperature profiles in an optimal interpolation framework. It is now recognized that correction of temperature only often introduces spurious water masses. The resulting density distribution can be statically unstable and also have a detrimental impact on the velocity distribution. Several simple schemes have been developed to try to correct these deficiencies. Here the salinity field is corrected by using a scheme which assumes that the temperature-salinity relationship of the model background is preserved during the assimilation. The scheme was first introduced for a zlevel model by Troccoli and Haines (1999). A large set of subsurface observations of salinity and temperature is used to cross-validate two data assimilation experiments run for the 6-year period 1993-1998. In these two experiments only subsurface temperature observations are used, but in one case the salinity field is also updated whenever temperature observations are available.

Detection of mycobacteria in aquarium fish in Slovenia by culture and molecular methods.

PubMed

Pate, M; Jencic, V; Zolnir-Dovc, M; Ocepek, M

2005-04-06

Thirty-five aquarium fish were investigated for the presence of mycobacteria by culture and molecular methods. The following species were examined: goldfish Carassius auratus auratus, guppy Poecilia reticulata, 4 three-spot gourami Trichogaster trichopterus, dwarf gourami Colisa lalia, Siamese fighting fish Betta splendens, freshwater angelfish Pterophyllum scalare, African cichlid fish Cichlidae spp., cichlid fish Microgeophagus altispinosus, cichlid fish Pseudotropheus lombardoi, blue streak hap Labidochromis caeruleus, sterlet Acipenser ruthenus, southern platyfish Xiphophorus maculatus, and catfish Corydoras spp. Isolates of mycobacteria were obtained in 29 cases (82.9%). Two specimens were positive using Ziehl-Neelsen (ZN) staining, but the cultivation failed. Four specimens were both ZN- and culture-negative. On the basis of GenoType Mycobacterium assay (Hain Life-science) and restriction enzyme analysis of the amplified products (PCR-RFLP), 23 isolates (79.3%) were identified: 7 as Mycobacterium fortuitum, 6 as M. gordonae, 6 as M. marinum, 3 as M. chelonae, and 1 as M. peregrinum. Five isolates remained unidentified (Mycobacterium spp.). One case probably represented a mixed infection (M. marinum/M. fortuitum). Since M. marinum infections are also detected in humans, the significance of mycobacteria in aquarium fish should not be overlooked.

Heat flux viscosity in collisional magnetized plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C., E-mail: cliu@pppl.gov; Fox, W.; Bhattacharjee, A.

2015-05-15

Momentum transport in collisional magnetized plasmas due to gradients in the heat flux, a “heat flux viscosity,” is demonstrated. Even though no net particle flux is associated with a heat flux, in a plasma there can still be momentum transport owing to the velocity dependence of the Coulomb collision frequency, analogous to the thermal force. This heat-flux viscosity may play an important role in numerous plasma environments, in particular, in strongly driven high-energy-density plasma, where strong heat flux can dominate over ordinary plasma flows. The heat flux viscosity can influence the dynamics of the magnetic field in plasmas through themore » generalized Ohm's law and may therefore play an important role as a dissipation mechanism allowing magnetic field line reconnection. The heat flux viscosity is calculated directly using the finite-difference method of Epperlein and Haines [Phys. Fluids 29, 1029 (1986)], which is shown to be more accurate than Braginskii's method [S. I. Braginskii, Rev. Plasma Phys. 1, 205 (1965)], and confirmed with one-dimensional collisional particle-in-cell simulations. The resulting transport coefficients are tabulated for ease of application.« less

Modelling the Effects of Temperature and Cloud Cover Change on Mountain Permafrost Distribution, Northwest Canada

NASA Astrophysics Data System (ADS)

Bonnaventure, P. P.; Lewkowicz, A. G.

2008-12-01

Spatial models of permafrost probability for three study areas in northwest Canada between 59°N and 61°N were perturbed to investigate climate change impacts. The models are empirical-statistical in nature, based on basal temperature of snow (BTS) measurements in winter, and summer ground-truthing of the presence or absence of frozen ground. Predictions of BTS values are made using independent variables of elevation and potential incoming solar radiation (PISR), both derived from a 30 m DEM. These are then transformed into the probability of the presence or absence of permafrost through logistic regression. Under present climate conditions, permafrost percentages in the study areas are 44% for Haines Summit, British Columbia, 38% for Wolf Creek, Yukon, and 69% for part of the Ruby Range, Yukon (Bonnaventure and Lewkowicz, 2008; Lewkowicz and Bonaventure, 2008). Scenarios of air temperature change from -2K (approximating Neoglacial conditions) to +5K (possible within the next century according to the IPCC) were examined for the three sites. Manipulations were carried out by lowering or raising the terrain within the DEM assuming a mean environmental lapse rate of 6.5K/km. Under a -2K scenario, permafrost extent increased by 22-43% in the three study areas. Under a +5K warming, permafrost essentially disappeared in Haines Summit and Wolf Creek, while in the Ruby Range less than 12% of the area remained perennially frozen. It should be emphasized that these model predictions are for equilibrium conditions which might not be attained for several decades or longer in areas of cold permafrost. Cloud cover changes of -10% to +10% were examined through adjusting the partitioning of direct beam and diffuse radiation in the PISR input field. Changes to permafrost extent were small, ranging from -2% to -4% for greater cloudiness with changes of the opposite magnitude for less cloud. The results show that air temperature change has a much greater potential to affect mountain

Determination of discharge during pulsating flow

USGS Publications Warehouse

Thompson, T.H.

1968-01-01

Pulsating flow in an open channel is a manifestation of unstable-flow conditions in which a series of translatory waves of perceptible magnitude develops and moves rapidly downstream. Pulsating flow is a matter of concern in the design and operation of steep-gradient channels. If it should occur at high stages in a channel designed for stable flow, the capacity of the channel may be inadequate at a discharge that is much smaller than that for which the channel was designed. If the overriding translatory wave carries an appreciable part of the total flow, conventional stream-gaging procedures cannot be used to determine the discharge; neither the conventional instrumentation nor conventional methodology is adequate. A method of determining the discharge during pulsating flow was tested in the Santa Anita Wash flood control channel in Arcadia, Calif., April 16, 1965. Observations of the dimensions and velocities of translatory waves were made during a period of controlled reservoir releases of about 100, 200, and 300 cfs (cubic feet per second). The method of computing discharge was based on (1) computation of the discharge in the overriding waves and (2) computation of the discharge in the shallow-depth, or overrun, part of the flow. Satisfactory results were obtained by this method. However, the procedure used-separating the flow into two components and then treating the shallow-depth component as though it were steady--has no theoretical basis. It is simply an expedient for use until laboratory investigation can provide a satisfactory analytical solution to the problem of computing discharge during pulsating flow. Sixteen months prior to the test in Santa Anita Wash, a robot camera had been designed .and programmed to obtain the data needed to compute discharge by the method described above. The photographic equipment had been installed in Haines Creek flood control channel in Los Angeles, Calif., but it had not been completely tested because of the infrequency of

A level set method for determining critical curvatures for drainage and imbibition.

PubMed

Prodanović, Masa; Bryant, Steven L

2006-12-15

An accurate description of the mechanics of pore level displacement of immiscible fluids could significantly improve the predictions from pore network models of capillary pressure-saturation curves, interfacial areas and relative permeability in real porous media. If we assume quasi-static displacement, at constant pressure and surface tension, pore scale interfaces are modeled as constant mean curvature surfaces, which are not easy to calculate. Moreover, the extremely irregular geometry of natural porous media makes it difficult to evaluate surface curvature values and corresponding geometric configurations of two fluids. Finally, accounting for the topological changes of the interface, such as splitting or merging, is nontrivial. We apply the level set method for tracking and propagating interfaces in order to robustly handle topological changes and to obtain geometrically correct interfaces. We describe a simple but robust model for determining critical curvatures for throat drainage and pore imbibition. The model is set up for quasi-static displacements but it nevertheless captures both reversible and irreversible behavior (Haines jump, pore body imbibition). The pore scale grain boundary conditions are extracted from model porous media and from imaged geometries in real rocks. The method gives quantitative agreement with measurements and with other theories and computational approaches.

The Ohio State 1991 geopotential and sea surface topography harmonic coefficient models

NASA Technical Reports Server (NTRS)

Rapp, Richard H.; Wang, Yan Ming; Pavlis, Nikolaos K.

1991-01-01

The computation is described of a geopotential model to deg 360, a sea surface topography model to deg 10/15, and adjusted Geosat orbits for the first year of the exact repeat mission (ERM). This study started from the GEM-T2 potential coefficient model and it's error covariance matrix and Geosat orbits (for 22 ERMs) computed by Haines et al. using the GEM-T2 model. The first step followed the general procedures which use a radial orbit error theory originally developed by English. The Geosat data was processed to find corrections to the a priori geopotential model, corrections to a radial orbit error model for 76 Geosat arcs, and coefficients of a harmonic representation of the sea surface topography. The second stage of the analysis took place by doing a combination of the GEM-T2 coefficients with 30 deg gravity data derived from surface gravity data and anomalies obtained from altimeter data. The analysis has shown how a high degree spherical harmonic model can be determined combining the best aspects of two different analysis techniques. The error analysis was described that has led to the accuracy estimates for all the coefficients to deg 360. Significant work is needed to improve the modeling effort.

Eastern Denali Fault surface trace map, eastern Alaska and Yukon, Canada

USGS Publications Warehouse

Bender, Adrian M.; Haeussler, Peter J.

2017-05-04

We map the 385-kilometer (km) long surface trace of the right-lateral, strike-slip Denali Fault between the Totschunda-Denali Fault intersection in Alaska, United States and the village of Haines Junction, Yukon, Canada. In Alaska, digital elevation models based on light detection and ranging and interferometric synthetic aperture radar data enabled our fault mapping at scales of 1:2,000 and 1:10,000, respectively. Lacking such resources in Yukon, we developed new structure-from-motion digital photogrammetry products from legacy aerial photos to map the fault surface trace at a scale of 1:10,000 east of the international border. The section of the fault that we map, referred to as the Eastern Denali Fault, did not rupture during the 2002 Denali Fault earthquake (moment magnitude 7.9). Seismologic, geodetic, and geomorphic evidence, along with a paleoseismic record of past ground-rupturing earthquakes, demonstrate Holocene and contemporary activity on the fault, however. This map of the Eastern Denali Fault surface trace complements other data sets by providing an openly accessible digital interpretation of the location, length, and continuity of the fault’s surface trace based on the accompanying digital topography dataset. Additionally, the digitized fault trace may provide geometric constraints useful for modeling earthquake scenarios and related seismic hazard.

Enhanced Cr bioleaching efficiency from tannery sludge with coinoculation of Acidithiobacillus thiooxidans TS6 and Brettanomyces B65 in an air-lift reactor.

PubMed

Fang, Di; Zhou, Li-Xiang

2007-09-01

Bioleaching process has been demonstrated to be an effective technology in removing Cr from tannery sludge, but a large quantity of dissolved organic matter (DOM) present in tannery sludge often exhibits a marked toxicity to chemolithoautotrophic bioleaching bacteria such as Acidithiobacillus thiooxidans. The purpose of the present study was therefore to enhance Cr bioleaching efficiencies through introducing sludge DOM-degrading heterotrophic microorganism into the sulfur-based sludge bioleaching system. An acid-tolerant DOM-degrading yeast strain Brettanomyces B65 was successfully isolated from a local Haining tannery sludge and it could metabolize sludge DOM as a source of energy and carbon for growth. A combined bioleaching experiment (coupling Brettanomyces B65 and A. thiooxidans TS6) performed in an air-lift reactor indicated that the rates of sludge pH reduction and ORP increase were greatly improved, resulting in enhanced Cr solubilization. Compared with the 5 days required for maximum solubilization of Cr for the control (single bioleaching process without inoculation of Brettanomyces B65), the bioleaching period was significantly shorten to 3 days for the combined bioleaching system. Moreover, little nitrogen and phosphorous were lost and the content of Cr was below the permitted levels for land application after 3 days of bioleaching treatment.

Compact and low-cost humanoid hand powered by nylon artificial muscles.

PubMed

Wu, Lianjun; Jung de Andrade, Monica; Saharan, Lokesh Kumar; Rome, Richard Steven; Baughman, Ray H; Tadesse, Yonas

2017-02-03

This paper focuses on design, fabrication and characterization of a biomimetic, compact, low-cost and lightweight 3D printed humanoid hand (TCP Hand) that is actuated by twisted and coiled polymeric (TCP) artificial muscles. The TCP muscles were recently introduced and provided unprecedented strain, mechanical work, and lifecycle (Haines et al 2014 Science 343 868-72). The five-fingered humanoid hand is under-actuated and has 16 degrees of freedom (DOF) in total (15 for fingers and 1 at the palm). In the under-actuated hand designs, a single actuator provides coupled motions at the phalanges of each finger. Two different designs are presented along with the essential elements consisting of actuators, springs, tendons and guide systems. Experiments were conducted to investigate the performance of the TCP muscles in response to the power input (power magnitude, type of wave form such as pulsed or square wave, and pulse duration) and the resulting actuation stroke and force generation. A kinematic model of the flexor tendons was developed to simulate the flexion motion and compare with experimental results. For fast finger movements, short high-power pulses were employed. Finally, we demonstrated the grasping of various objects using the humanoid TCP hand showing an array of functions similar to a natural hand.

The Effect of an Energy Audit Service Learning Project on Student Perceptions of STEM Related Disciplines, Personal Behaviors/Actions towards the Environment, and Stewardship Skills

NASA Astrophysics Data System (ADS)

Gullo, Michael

The purpose of this study was to investigate whether or not service learning could be considered an alternative teaching method in an environmental science classroom. In particular, the results of this research show whether an energy audit service learning project influenced student environmental awareness (knowledge of environmental issues, problems, and solutions), student personal actions/behaviors towards the environment, student perceptions and attitudes of science related careers, and community partnerships. Haines (2010) defines service learning as “a teaching and learning strategy that integrates meaningful community service with instruction and reflection to enrich the learning experience, teach civic responsibility, and strengthen communities” (p. 16). Moreover, service learning opportunities can encourage students to step out of their comfort zone and learn from hands-on experiences and apply knowledge obtained from lectures and classroom activities to real life situations. To add to the growing body of literature, the results of this study concluded that an energy audit service learning project did not have a measureable effect on student perceptions and attitudes of science related careers as compared to a more traditional teaching approach. However, the data from this study did indicate that an energy audit service learning project increased students personal actions/behaviors towards the environment more than a direct teaching approach.

Haines Board: A Review of Army School System for Officer Education and Training. USAIS Position. Volume 1 and Factual Data. Volume 2

DTIC Science & Technology

1965-07-01

currently not suitable for general publica - tion, but which, because of their implication in the future, merit the atten- tion of senior Infantry...OC selection and evaluation, sug- gestions on departmental organization, evaluation of officer students, course prerequisites, attrition

Three year evaluation of Xpert MTB/RIF in a low prevalence tuberculosis setting: A Scottish perspective.

PubMed

Parcell, Benjamin J; Jarchow-MacDonald, Anna A; Seagar, Amie-Louise; Laurenson, Ian F; Prescott, Gordon J; Lockhart, Michael

2017-05-01

Xpert MTB/RIF (Cepheid) is a rapid molecular assay shown to be sensitive and specific for pulmonary tuberculosis (TB) diagnosis in highly endemic countries. We evaluated its diagnostic performance in a low TB prevalence setting, examined rifampicin resistance detection and quantitative capabilities predicting graded auramine microscopy and time to positivity (TTP) of culture. Xpert MTB/RIF was used to test respiratory samples over a 3 year period. Samples underwent graded auramine microscopy, solid/liquid culture, in-house IS6110 real-time PCR, and GenoType MTBDRplus (HAIN Lifescience) to determine rifampicin and/or isoniazid resistance. A total of 2103 Xpert MTB/RIF tests were performed. Compared to culture sensitivity was 95.8%, specificity 99.5%, positive predictive value (PPV) 82.1%, and negative predictive value (NPV) 99.9%. A positive correlation was found between auramine microscopy grade and Xpert MTB/RIF assay load. We found a clear reduction in the median TTP as Xpert MTB/RIF assay load increased. Rifampicin resistance was detected. Xpert MTB/RIF was rapid and accurate in diagnosing pulmonary TB in a low prevalence area. Rapid results will influence infection prevention and control and treatment measures. The excellent NPV obtained suggests further work should be carried out to assess its role in replacing microscopy. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

The use of computed tomography scans and the Bender Gestalt Test in the assessment of competency to stand trial and criminal responsibility in the field of mental health and law.

PubMed

Mosotho, Nathaniel Lehlohonolo; Timile, Ino; Joubert, Gina

computed tomography and the Bender Gestalt Test are some of the tests used routinely for the assessment of alleged offenders referred under Sections 77 and 78 of the Criminal Procedure Act 51 of 1977. An exploratory retrospective study was conducted at the Free State Psychiatric Complex. The aim of this study was to identify the extent to which the Bender Gestalt Test results and the computed tomography scans are associated with outcomes in the assessment of competency to stand trial and criminal responsibility in individuals referred to the Free State Psychiatric Complex (FSPC) observation unit. This was a cross-sectional study and the entire population of patients admitted in 2013 was included in the study. The clinical and demographic data were obtained from patient files. The majority of participants were black, males, single and unemployed. The most common diagnosis was schizophrenia. The current study showed no statistically significant association between the Bender Gestalt Test Hain's scores and the outcome of criminal responsibility and competency to stand trial. Similarly, the study also showed no statistically significant association between the presence of a brain lesion and the outcome of criminal responsibility and competency to stand trial. It was also concluded that as CT scans are expensive, patients should be referred for that service only when there is a clear clinical indication to do so. Copyright © 2016 Elsevier Ltd. All rights reserved.

Scientists as Producers, Presenters, Videographers, Distributors and 'Stars': The Revolution In Science Filmmaking, from COSMOS to iPhones on Kilimanjaro

NASA Astrophysics Data System (ADS)

Haines-Stiles, G.; Akuginow, E.; Morris, K.

2013-12-01

In 1980, Carl Sagan's COSMOS received ratings of some 16 million and won three Emmys and a Peabody award. Sagan was hailed as a 'Showman of Science' by Time magazine, confirming his status as a science superstar. Haines-Stiles, 1st author for this presentation, was a Senior Producer and series director on what was for several decades PBS's highest-rated science series. Some researchers still consider primetime series on national networks as THE way to engage and inform audiences. But a revolution in both the making and consuming of science film and television has transformed the media landscape from high profile series such as COSMOS to more of a 'horizontal' ecosystem in which different formats for diverse audiences via multiple distribution networks are the norm. From the early 1990's the Internet has played an increasingly prominent role in this revolution. In 1993, Haines-Stiles and Akuginow added interactivity to traditional one-way TV broadcasts with 'Dale's Dive Diary,' in what was arguably the world's first science blog, detailing online the joys and rigors of working in Antarctica. Increasingly, the evolution of media allowed for the documentation of the process of doing science along with "eureka" discoveries and press conference results. In POLAR-PALOOZA (PPZA) this new perspective was further extended by taking Arctic and Antarctic researchers on the road to science museums in some 25 communities across the USA for spoken-word performances supported by High Definition video profiles of scientists at work at remote locations. In one instance, a researcher was given a crash course in videography and loaned a low-cost prosumer camcorder to take with her to the heart of East Antarctica. Excellent video was captured, and made part of large screen presentations in IMAX-scale theaters. In addition to the Summative Evaluation (required by project sponsors, NSF and NASA) which focused on audience responses, a recent research paper by communications scholar, Kim

Identifying On-Orbit Test Targets for Space Fence Operational Testing

NASA Astrophysics Data System (ADS)

Pechkis, D.; Pacheco, N.; Botting, T.

2014-09-01

Space Fence will be an integrated system of two ground-based, S-band (2 to 4 GHz) phased-array radars located in Kwajalein and perhaps Western Australia [1]. Space Fence will cooperate with other Space Surveillance Network sensors to provide space object tracking and radar characterization data to support U.S. Strategic Command space object catalog maintenance and other space situational awareness needs. We present a rigorous statistical test design intended to test Space Fence to the letter of the program requirements as well as to characterize the system performance across the entire operational envelope. The design uses altitude, size, and inclination as independent factors in statistical tests of dependent variables (e.g., observation accuracy) linked to requirements. The analysis derives the type and number of necessary test targets. Comparing the resulting sample sizes with the number of currently known targets, we identify those areas where modelling and simulation methods are needed. Assuming hypothetical Kwajalein radar coverage and a conservative number of radar passes per object per day, we conclude that tests involving real-world space objects should take no more than 25 days to evaluate all operational requirements; almost 60 percent of the requirements can be tested in a single day and nearly 90 percent can be tested in one week or less. Reference: [1] L. Haines and P. Phu, Space Fence PDR Concept Development Phase, 2011 AMOS Conference Technical Papers.

An analytic study of nonsteady two-phase laminar boundary layer around an airfoil

NASA Technical Reports Server (NTRS)

Hsu, Yu-Kao

1989-01-01

Recently, NASA, FAA, and other organizations have focused their attention upon the possible effects of rain on airfoil performance. Rhode carried out early experiments and concluded that the rain impacting the aircraft increased the drag. Bergrum made numerical calculation for the rain effects on airfoils. Luers and Haines did an analytic investigation and found that heavy rain induces severe aerodynamic penalties including both a momentum penalty due to the impact of the rain and a drag and lift penalty due to rain roughening of the airfoil and fuselage. More recently, Hansman and Barsotti performed experiments and declared that performance degradation of an airfoil in heavy rain is due to the effective roughening of the surface by the water layer. Hansman and Craig did further experimental research at low Reynolds number. E. Dunham made a critical review for the potential influence of rain on airfoil performance. Dunham et al. carried out experiments for the transport type airfoil and concluded that there is a reduction of maximum lift capability with increase in drag. There is a scarcity of published literature in analytic research of two-phase boundary layer around an airfoil. Analytic research is being improved. The following assumptions are made: the fluid flow is non-steady, viscous, and incompressible; the airfoil is represented by a two-dimensional flat plate; and there is only a laminar boundary layer throughout the flow region. The boundary layer approximation is solved and discussed.

Detection of KatG/inhA Mutation to Guide Isoniazid and Ethionamide Use for Drug-resistant Tuberculosis

PubMed Central

Namburete, Evangelina

2017-01-01

Abstract Background Both Mozambique and Brazil are countries with a high burden of tuberculosis. Isoniazid (INH) is one of the cornerstones of tuberculosis treatment and, depending on the mutated gene (katG or inhA), the organism may be susceptible to high doses of INH (inhA mutation) or to ethionamide (-Eth-KatG mutation). Methods To analyze isoniazid genotypic resistance profile in Mycobacterium tuberculosis to guide decision making about management of resistant tuberculosis. Descriptive study of 311 M. tuberculosis isolated from Ribeirão Preto, Brazil (2011–2014) and 155 isolates from Beira, Mozambique (2014–2015). Drug resistance patterns and the specific genes mutations were determined using Genotype MTBDRplus (Hain Lifescience GmbH, Germany). Results Mutations in katG gene were detected in 13/22 (59%) of Brazilian and in 32/38 (84.2%) of Mozambican isolates. Unique inhA mutations were observed in 8/22 (36%) isolates in Brazil and 4/38 (10.5%) in Mozambique. Both katG and inhA mutations where detected in 1/22 (5%) and 2/38(5.2%), respectively. katG mutations were more frequent among INH previously treated patients. Conclusion There is a geographical variation of INH mutations and the new molecular tests can be used to guide and accelerate decision making towards the use of ETH or high doses of INH based on detected mutations. Disclosures All authors: No reported disclosures.

Mountain Permafrost in the Yukon Territory, Canada: Mapping and Modelling

NASA Astrophysics Data System (ADS)

Lewkowicz, A. G.; Bonnaventure, P.; Schultz, E.; Etzelmuller, B.

2006-12-01

The distribution and characteristics of mountain permafrost in North America are poorly known compared to lowland permafrost, and predictions of climatic change impacts are therefore subject to a higher degree of uncertainty. Recent DC resistivity soundings in association with borehole temperature information in the Yukon Territory, show the wide range of permafrost conditions that can exist at sites separated by short distances. To provide baseline information for future modelling, efforts are underway to produce a detailed map of permafrost probability in the mountains of the southern half of the Yukon Territory (60-65°N), an area greater than 200 x 103km2. The methodology is based on the Basal Temperature of Snow (BTS) technique, first developed in the European Alps. Ground surface temperatures measured at the base of snow > 80 cm thick in late winter are an indicator of permafrost presence or absence. We have used this method successfully in three study areas of about 200 km2: first, Wolf Creek basin near Whitehorse (Lewkowicz and Ednie, 2004) and now the western side of the Ruby Range adjacent to Kluane Lake, and the Haines Summit area in northwestern British Columbia. In each area, (1) we installed miniature temperature loggers at the ground surface and in the air to check on the timing of the BTS measurements; (2) we measured BTS values in the elevation zone across which permafrost was expected to become widespread; (3) we modelled the BTS spatial field using elevation (from a 30 m DEM) and potential incoming solar radiation (PISR) as the independent variables; and (4) we used logistic regression to compare the modelled BTS values with pit observations made in late-summer of the presence or absence of frozen ground. Both elevation and PISR were significant in the Wolf Creek and Ruby Range sites which have relatively continental climates and fall within the Upper Yukon-Stikine Basin climatic region (Wahl et al., 1987). For the Haines Summit area, however

Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of micro-organisms in the routine clinical microbiology laboratory.

PubMed

Wattal, C; Oberoi, J K; Goel, N; Raveendran, R; Khanna, S

2017-05-01

The study evaluates the utility of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) Vitek MS for identification of microorganisms in the routine clinical microbiology laboratory. From May 2013 to April 2014, microbial isolates recovered from various clinical samples were identified by Vitek MS. In case of failure to identify by Vitek MS, the isolate was identified using the Vitek 2 system (bioMerieux, France) and serotyping wherever applicable or otherwise by nucleic acid-mediated methods. All the moulds were identified by Lactophenol blue mounts, and mycobacterial isolates were identified by molecular identification systems including AccuProbe (bioMerieux, France) or GenoType Mycobacterium CM (Hain Lifescience, Germany). Out of the 12,003 isolates, the Vitek MS gave a good overall ID at the genus and or species level up to 97.7% for bacterial isolates, 92.8% for yeasts and 80% for filamentous fungi. Of the 26 mycobacteria tested, only 42.3% could be identified using the Saramis RUO (Research Use Only) database. VITEK MS could not identify 34 of the 35 yeast isolates identified as C. haemulonii by Vitek 2. Subsequently, 17 of these isolates were identified as Candida auris (not present in the Vitek MS database) by 18S rRNA sequencing. Using these strains, an in-house superspectrum of C. auris was created in the VITEK MS database. Use of MALDI-TOF MS allows a rapid identification of aerobic bacteria and yeasts in clinical practice. However, improved sample extraction protocols and database upgrades with inclusion of locally representative strains is required, especially for moulds.

Detection of periodontopathogenic bacteria in pregnant women by traditional anaerobic culture method and by a commercial molecular genetic method.

PubMed

Urbán, Edit; Terhes, Gabriella; Radnai, Márta; Gorzó, István; Nagy, Elisabeth

2010-06-01

To culture facultative and strict anaerobic bacteria is a well-established method for analyzing subgingival plaque samples. Micro-IDent and micro-IDent Plus (HAIN Lifescience GmbH, Nehren, Germany) tests are two commercially available rapid PCR-based methods for the identification and quantification of putative periodontopathogen bacteria. In this study, we compared these commercial PCR-based hybridization methods with conventional anaerobic culture technique. A total of 36 subgingival plaque samples were collected from periodontal pockets of pregnant women with chronic localized periodontitis. Aliquots of these samples were evaluated with species-specific probes provided by micro-IDent and micro-IDent Plus tests simultaneously, and from the same samples anaerobic and capnophylic bacteria were cultured on selective media. The overall agreement between both methods was excellent for Eubacterium nodatum, Tannerella forsythia and Porphyromonas gingivalis (97-92%), fair for Capnocytophaga sp, Eikenella corrodens, Actinobacillus actinomycetemcomitans, and Prevotella intermedia (91-89%) and poor for Fusobacterium nucleatum, Parvimonas micra (Micromonas micros), and Campylobacter rectus (86-78%). Discrepancies in the results may be explained by inability of culture method to distinguish between closely related taxa (e.i P. intermedia/Prevotella. nigrescens), and problems of keeping periodontopathogen bacteria viable, which is required for successful detection by standard culture method. Nucleic acid-based methods may replace cultivation method as frequently used methods in microbiological diagnosis of progressive periodontitis, thus micro-IDent and micro-IDent Plus tests can be recommended where culture of periodontopathogenic bacteria is not performed in routine microbiology laboratories to analyze subgingival plaque samples. 2010 Elsevier Ltd. All rights reserved.

Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.

PubMed

Aung, Wah Wah; Ei, Phyu Win; Nyunt, Wint Wint; Swe, Thyn Lei; Lwin, Thandar; Htwe, Mi Mi; Kim, Kyung Jun; Lee, Jong Seok; Kim, Chang Ki; Cho, Sang Nae; Song, Sun Dae; Chang, Chulhun L

2015-09-01

Tuberculosis (TB) is one of the most serious health problems in Myanmar. Because TB drug resistance is associated with genetic mutation(s) relevant to responses to each drug, genotypic methods for detecting these mutations have been proposed to overcome the limitations of classic phenotypic drug susceptibility testing (DST). We explored the current estimates of drug-resistant TB and evaluated the usefulness of genotypic DST in Myanmar. We determined the drug susceptibility of Mycobacterium tuberculosis isolated from sputum smear-positive patients with newly diagnosed pulmonary TB at two main TB centers in Myanmar during 2013 by using conventional phenotypic DST and the GenoType MTBDRplus assay (Hain Lifescience, Germany). Discrepant results were confirmed by sequencing the genes relevant to each type of resistance (rpoB for rifampicin; katG and inhA for isoniazid). Of 191 isolates, phenotypic DST showed that 27.7% (n=53) were resistant to at least one first-line drug and 20.9% (n=40) were resistant to two or more, including 18.3% (n=35) multidrug-resistant TB (MDR-TB) strains. Monoresistant strains accounted for 6.8% (n=13) of the samples. Genotypic assay of 189 isolates showed 17.5% (n=33) MDR-TB and 5.3% (n=10) isoniazid-monoresistant strains. Genotypic susceptibility results were 99.5% (n=188) concordant and agreed almost perfectly with phenotypic DST (kappa=0.99; 95% confidence interval 0.96-1.01). The results highlight the burden of TB drug resistance and prove the usefulness of the genotypic DST in Myanmar.

Adiabatic burst evaporation from bicontinuous nanoporous membranes

PubMed Central

Ichilmann, Sachar; Rücker, Kerstin; Haase, Markus; Enke, Dirk

2015-01-01

Evaporation of volatile liquids from nanoporous media with bicontinuous morphology and pore diameters of a few 10 nm is an ubiquitous process. For example, such drying processes occur during syntheses of nanoporous materials by sol–gel chemistry or by spinodal decomposition in the presence of solvents as well as during solution impregnation of nanoporous hosts with functional guests. It is commonly assumed that drying is endothermic and driven by non-equilibrium partial pressures of the evaporating species in the gas phase. We show that nearly half of the liquid evaporates in an adiabatic mode involving burst-like liquid-to-gas conversions. During single adiabatic burst evaporation events liquid volumes of up to 107 μm3 are converted to gas. The adiabatic liquid-to-gas conversions occur if air invasion fronts get unstable because of the built-up of high capillary pressures. Adiabatic evaporation bursts propagate avalanche-like through the nanopore systems until the air invasion fronts have reached new stable configurations. Adiabatic cavitation bursts thus compete with Haines jumps involving air invasion front relaxation by local liquid flow without enhanced mass transport out of the nanoporous medium and prevail if the mean pore diameter is in the range of a few 10 nm. The results reported here may help optimize membrane preparation via solvent-based approaches, solution-loading of nanopore systems with guest materials as well as routine use of nanoporous membranes with bicontinuous morphology and may contribute to better understanding of adsorption/desorption processes in nanoporous media. PMID:25926406

Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis

PubMed Central

Cudahy, Patrick G.T; Schumacher, Samuel G.; Steingart, Karen R.; Pai, Madhukar; Denkinger, Claudia M.

2017-01-01

Only 25% of multidrug-resistant tuberculosis (MDR-TB) cases are currently diagnosed. Line probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and isoniazid (INH) resistance and Mycobacterium tuberculosis detection. Genotype MTBDRplusV1 was WHO-endorsed in 2008 but newer LPAs have since been developed. This systematic review evaluated three LPAs: Hain Genotype MTBDRplusV1, MTBDRplusV2 and Nipro NTM+MDRTB. Study quality was assessed with QUADAS-2. Bivariate random-effects meta-analyses were performed for direct and indirect testing. Results for RIF and INH resistance were compared to phenotypic and composite (incorporating sequencing) reference standards. M. tuberculosis detection results were compared to culture. 74 unique studies were included. For RIF resistance (21 225 samples), pooled sensitivity and specificity (with 95% confidence intervals) were 96.7% (95.6–97.5%) and 98.8% (98.2–99.2%). For INH resistance (20 954 samples), pooled sensitivity and specificity were 90.2% (88.2–91.9%) and 99.2% (98.7–99.5%). Results were similar for direct and indirect testing and across LPAs. Using a composite reference standard, specificity increased marginally. For M. tuberculosis detection (3451 samples), pooled sensitivity was 94% (89.4–99.4%) for smear-positive specimens and 44% (20.2–71.7%) for smear-negative specimens. In patients with pulmonary TB, LPAs have high sensitivity and specificity for RIF resistance and high specificity and good sensitivity for INH resistance. This meta-analysis provides evidence for policy and practice. PMID:28100546

[Estimation of N loss loading by runoff from paddy field during submersed period in Hangjiahu area].

PubMed

Tian, Ping; Chen, Yingxu; Tian, Guangming; Liang, Xinqiang; Zhang, Qiuling; Yu, Qiaogang; Li, Hua

2006-10-01

As the largest bread basket in Zhejiang Province, Hangjiahu area is facing more and more serious water pollution, while the N loss loading by runoff from the paddy field during its submersed period is the main cause of the pollution. Through field experiment and fixed spot observation, the model of precipitation - runoff in Yangtze delta was testified, and the results showed that the precipitation - runoff model from HE Baogen was basically accorded with the fact after considering the impact of field overflow mouth, and the error was between - 19. 9% and + 18. 0%. The model of N concentration with precipitation - runoff in paddy field during submersed period was brought forward, with the R value being 0. 948. These two models consisted of the model of N loss loading by runoff from paddy field during submersed period. Based on this model as well as the past 30 years data of fertilization and precipitation, 1: 250,000 topography map, land use map, and water system map, the N loss loading and its distribution were estimated by using GIS method, and the results showed that the N loss loading was different from place to place, with an average of 35.26 kg N x hm(-2), and accounting for 12. 69% of the applied N. The N loss loading in Anji and Yuhang with obviously more precipitation was higher than that in other places, while Haining also had a serious N loss problem because of the huge amount of applied N.

Suction and cohesion demise in desaturating granular medium

NASA Astrophysics Data System (ADS)

Hueckel, T.; Mielniczuk, B.; El-Youssoufi, S. M.

2017-12-01

Continuum mechanics for unsaturated soils is based on the assumption of a one-to-one relationship betwee saturation degree and suction represented by the characteristic curve. Such curve commonly shows exceedingly high values of suction at saturation decreasing below 10%. We have performed a series of experiments on physical micro-structural models of 8-, 5, 4, 3, and 2-grain assemblies filled with water forming capillary, funicular and pendular bridges. Dynamic variables characterizing the evolution include: Laplace pressure, surface tension force, total intergralular force, contact angle and contact perimeter length. The Laplace pressure was calculated from the directly measured curvatures of interface surface for 2-grain bridges, and estimated from tomography stills for 3 grain bridges. The initial negative Laplace pressure (suction) as well as total intergranular force increase modestly at the begining of evaporation, but undergo an unstable decrease at the advanced stage, often with a jump in the force known as a Haines jumps since 1925. Laplace pressure turns into positive values prior to rupture for 2-grain bodies. For 3-grain bridges there is never an exceedingly high intergranular force of suction, reported in macro-scale experiments. For multiple-grain bodies there are two types of instabilities, depending on densitiy of the assembly and the Gaussian curvature (GC): at positive GC points it is thin-sheet instability, while at negative GC points instability is linked with air entry fingers, all associated with the split of assemblies into smaller isolated funicular, and eventually pendular bodies. The multi-grain bridges instabilities are linked to material drying cracking, the instabilities in 2 grain systems mean eventual loss of cohesion.

Towards Improved Estimates of Ocean Heat Flux

NASA Astrophysics Data System (ADS)

Bentamy, Abderrahim; Hollman, Rainer; Kent, Elisabeth; Haines, Keith

2014-05-01

Recommendations and priorities for ocean heat flux research are for instance outlined in recent CLIVAR and WCRP reports, eg. Yu et al (2013). Among these is the need for improving the accuracy, the consistency, and the spatial and temporal resolution of air-sea fluxes over global as well as at region scales. To meet the main air-sea flux requirements, this study is aimed at obtaining and analyzing all the heat flux components (latent, sensible and radiative) at the ocean surface over global oceans using multiple satellite sensor observations in combination with in-situ measurements and numerical model analyses. The fluxes will be generated daily and monthly for the 20-year (1992-2011) period, between 80N and 80S and at 0.25deg resolution. Simultaneous estimates of all surface heat flux terms have not yet been calculated at such large scale and long time period. Such an effort requires a wide range of expertise and data sources that only recently are becoming available. Needed are methods for integrating many data sources to calculate energy fluxes (short-wave, long wave, sensible and latent heat) across the air-sea interface. We have access to all the relevant, recently available satellite data to perform such computations. Yu, L., K. Haines, M. Bourassa, M. Cronin, S. Gulev, S. Josey, S. Kato, A. Kumar, T. Lee, D. Roemmich: Towards achieving global closure of ocean heat and freshwater budgets: Recommendations for advancing research in air-sea fluxes through collaborative activities. INTERNATIONAL CLIVAR PROJECT OFFICE, 2013: International CLIVAR Publication Series No 189. http://www.clivar.org/sites/default/files/ICPO189_WHOI_fluxes_workshop.pdf

Preference for sons: past and present.

PubMed

Li, D

1997-10-01

This brief article discusses the present and past preference for sons in China. The preference for sons is rooted in feudal views that men are superior to women. Preference for sons dates back to the Warring States Period, in about 500 B.C. Clan brotherhoods of men have existed for centuries. Historical records mention the practice of female infanticide. Patriarchal families believed that women were economically dependent on men and thus became their subjects. Daughters married, lived in their husband's home, and did not carry the responsibility of caring for their own parents. Couples with only daughters would seek a son-in-law to support them in old age. Rural families with no sons were looked down upon. Sons were expected to carry on the family lineage, increase the reputation of the family, and protect the family's interests. The lack of sons was a sign of humiliation and a curse. The founding of the People's Republic of China brought changes to son preference. The government attempted to increase women's status. In rural areas, women were given equal access to the land. Job opportunities were created for women during the industrialization drive. The Chinese government encouraged the repudiation of the negative impacts of the doctrines of Confucius and Mencius. Efforts were made to give men and women equal pay for equal work. Legislation was passed prohibiting arranged marriage, polygyny, and early marriage. A side effect of fertility decline is the renewed preference for sons. In Huangyan and Haining in Zhejiang, a developed province, the sex ratio at birth is normal. Sexual division of labor reinforces son preference.

Position control of twisted and coiled polymer actuator using a controlled fan for cooling

NASA Astrophysics Data System (ADS)

Takagi, Kentaro; Arakawa, Takeshi; Takeda, Jun; Masuya, Ken; Tahara, Kenji; Asaka, Kinji

2017-04-01

Recently, artificial muscles made of fishing lines or sewing threads, namely twisted and coiled polymer actuators (TCPAs), have been proposed by Haines et al. A TCPA contracts by applying heat and returns to its initial length by cooling. A TCPA can be driven by voltage if the TCPA is plated by metal or if conductive wire such as nichrome is wound around it. Compared with the conventional electroactive polymers, advantages of TCPAs are low cost, simple structure, large actuation strain, and large force. However, a big disadvantage of TCPAs is slow response due to heat transfer. The problem becomes apparent during cooling, although the response of heating can be improved by feedback control. This paper proposes a control method of switching heating and cooling. In the proposed method, a TCPA is cooled by an electric cooling fan. When the TCPA is heating, the cooling fan is stopped. In a previous report, the response speed can be improved by keeping cooling fan always on; however, unnecessary energy consumption is required even during heating. In the proposed method, energy consumption during heating does not increase and the response speed can be improved using fan only during cooling. The proposed control law is as follows. Firstly, the desired control input is determined by PI-D control with respect to the length of the actuator. Then, the control inputs to the heater and to the cooling fan are switched according to the sign of the PI-D controller output. The effectiveness of the proposed control method is demonstrated by comparing the cases with and without the cooling fan in the experiments.

Physiotherapy students and clinical educators perceive several ways in which incorporating peer-assisted learning could improve clinical placements: a qualitative study.

PubMed

Sevenhuysen, Samantha; Farlie, Melanie K; Keating, Jennifer L; Haines, Terry P; Molloy, Elizabeth

2015-04-01

What are the experiences of students and clinical educators in a paired student placement model incorporating facilitated peer-assisted learning (PAL) activities, compared to a traditional paired teaching approach? Qualitative study utilising focus groups. Twenty-four physiotherapy students and 12 clinical educators. Participants in this study had experienced two models of physiotherapy clinical undergraduate education: a traditional paired model (usual clinical supervision and learning activities led by clinical educators supervising pairs of students) and a PAL model (a standardised series of learning activities undertaken by student pairs and clinical educators to facilitate peer interaction using guided strategies). Peer-assisted learning appears to reduce the students' anxiety, enhance their sense of safety in the learning environment, reduce educator burden, maximise the use of downtime, and build professional skills including collaboration and feedback. While PAL adds to the clinical learning experience, it is not considered to be a substitute for observation of the clinical educator, expert feedback and guidance, or hands-on immersive learning activities. Cohesion of the student-student relationship was seen as an enabler of successful PAL. Students and educators perceive that PAL can help to position students as active learners through reduced dependence on the clinical educator, heightened roles in observing practice, and making and communicating evaluative judgments about quality of practice. The role of the clinical educator is not diminished with PAL, but rather is central in designing flexible and meaningful peer-based experiences and in balancing PAL with independent learning opportunities. ACTRN12610000859088. [Sevenhuysen S, Farlie MK, Keating JL, Haines TP, Molloy E (2015) Physiotherapy students and clinical educators perceive several ways in which incorporating peer-assisted learning could improve clinical placements: a qualitative study

Formulating physical processes in a full-range model of soil water retention

NASA Astrophysics Data System (ADS)

Nimmo, J. R.

2016-12-01

Currently-used water retention models vary in how much their formulas correspond to controlling physical processes such as capillarity, adsorption, and air-trapping. In model development, realistic correspondence to physical processes has often been a lower priority than ease of use and compatibility with other models. For example, the wettest range is normally represented simplistically, as by a straight line of zero slope, or by default using the same formulation as for the middle range. The new model presented here recognizes dominant processes within three segments of the range from oven-dryness to saturation. The adsorption-dominated dry range is represented by a logarithmic relation used in earlier models. The middle range of capillary advance/retreat and Haines jumps is represented by a new adaptation of the lognormal distribution function. In the wet range, the expansion of trapped air in response to matric pressure change is important because (1) it displaces water, and (2) it triggers additional volume-adjusting processes such as the collapse of liquid bridges between air pockets. For this range, the model incorporates the Boyles' law inverse-proportionality of trapped air volume and pressure, amplified by an empirical factor to account for the additional processes. With their basis in processes, the model's parameters have a strong physical interpretation, and in many cases can be assigned values from knowledge of fundamental relationships or individual measurements. An advantage of the physically-plausible treatment of the wet range is that it avoids such problems as the blowing-up of derivatives on approach to saturation, enhancing the model's utility for important but challenging wet-range phenomena such as domain exchange between preferential flow paths and soil matrix. Further development might be able to accommodate hysteresis by a systematic adjustment of the relation between the wet and middle ranges.

Wave Gradiometry for the Central U.S

NASA Astrophysics Data System (ADS)

liu, Y.; Holt, W. E.

2013-12-01

Wave gradiometry is a new technique utilizing the shape of seismic wave fields captured by USArray transportable stations to determine fundamental wave propagation characteristics. The horizontal and vertical wave displacements, spatial gradients and time derivatives of displacement are linearly linked by two coefficients which can be used to infer wave slowness, back azimuth, radiation pattern and geometrical spreading. The reducing velocity method from Langston [2007] is applied to pre-process our data. Spatial gradients of the shifted displacement fields are estimated using bi-cubic splines [Beavan and Haines, 2001]. Using singular value decomposition, the spatial gradients are then inverted to iteratively solve for wave parameters mentioned above. Numerical experiments with synthetic data sets provided by Princeton University's Neal Real Time Global Seismicity Portal are conducted to test the algorithm stability and evaluate errors. Our results based on real records in the central U.S. show that, the average Rayleigh wave phase velocity ranges from 3.8 to 4.2 km/s for periods from 60-125s, and 3.6 to 4.0 km/s for periods from 25-60s, which is consistent with earth model. Geometrical spreading and radiation pattern show similar features between different frequency bands. Azimuth variations are partially correlated with phase velocity change. Finally, we calculated waveform amplitude and spatial gradient uncertainties to determine formal errors in the estimated wave parameters. Further effort will be put into calculating shear wave velocity structure with respect to depth in the studied area. The wave gradiometry method is now being employed across the USArray using real observations and results obtained to date are for stations in eastern portion of the U.S. Rayleigh wave phase velocity derived from Aug, 20th, 2011 Vanuatu earthquake for periods from 100 - 125 s.

High-Pressure Behavior of Difluorides: The Case of SrF2

NASA Astrophysics Data System (ADS)

Swadba, K. E.; Stan, C. V.; Dutta, R.; Prakapenka, V.; Duffy, T. S.

2016-12-01

The high-pressure behavior of compounds in the AX2 family has attracted much attention due to their extensive polymorphism, highly coordinated structures, and diverse transformation pathways. The canonical transformation sequence for alkaline earth difluorides is from the fluorite-type structure (8 coordinated) to cotunnite (9 coordinated) to Ni2In (11 coordinated). Lead Fluoride, on the other hand, undergoes an unusual isosymmetric transition from cotunnite to a Co2Si-type structure (10 coordinated) at high pressures, during which it exhibits highly anisotropic lattice parameter trends (Haines et al, 1998; Stan et al 2016). Sr has a similar ionic radius as Pb, and is thus a good candidate for further exploring the compressional anisotropy in alkaline earth fluorides. In this study, we report a detailed examination of the compressional behavior of SrF2 to identify whether an intermediate phase occurs in this system prior to transformation to the Ni2In structure. Raman spectroscopy and x-ray diffraction experiments, performed at Princeton University and the Advanced Photon Source GSECARS beamline, respectively, were carried out on SrF2 up to 63 GPa using a diamond anvil cell. From Raman spectroscopy, we observed evidence for a high-pressure phase transition between 38.9 and 51.0 GPa. The x-ray diffraction data in this region show evidence for highly anisotropic compression, most notably a strong negative compressibility in the b direction, in the pressure region from 45.2 to 51.6 GPa. Comparison of our data with lattice parameter systematics for AX2 phases indicates that our results are consistent with the formation of the Co2Si phase in this region, along with a sluggish transformation to the Ni2In-type structure. Our findings contribute to a broader understanding of AX2 compounds and their phase transition pathways.

Carbon dioxide solubility in aqueous solutions of sodium chloride at geological conditions: Experimental results at 323.15, 373.15, and 423.15 K and 150 bar and modeling up to 573.15 K and 2000 bar

NASA Astrophysics Data System (ADS)

Zhao, Haining; Fedkin, Mark V.; Dilmore, Robert M.; Lvov, Serguei N.

2015-01-01

A new experimental system was designed to measure the solubility of CO2 at pressures and temperatures (150 bar, 323.15-423.15 K) relevant to geologic CO2 sequestration. At 150 bar, new CO2 solubility data in the aqueous phase were obtained at 323.15, 373.15, and 423.15 K from 0 to 6 mol kg-1 NaCl(aq) for the CO2-NaCl-H2O system. A γ - φ (activity coefficient - fugacity coefficient) type thermodynamic model is presented for the calculation of both the solubility of CO2 in the aqueous phase and the solubility of H2O in the CO2-rich phase for the CO2-NaCl-H2O system. Validation of the model calculations against literature data and other models (MZLL2013, AD2010, SP2010, DS2006, and OLI) show that the proposed model is capable of predicting the solubility of CO2 in the aqueous phase for the CO2-H2O and CO2-NaCl-H2O systems with a high degree of accuracy (AAD <3.9%) at temperatures from 273.15 to 573.15 K and pressures up to 2000 bar. A comparison of modeling results with experimental values revealed a pressure-bounded "transition zone" in which the CO2 solubility decreases to a minimum then increases as the temperature increases. CO2 solubility is not a monotonic function of temperature in the transition zone but outside of that transition zone, the CO2 solubility is decrease or increase monotonically in response to increased temperature. A link of web-based CO2 solubility computational tool can be provided by sending a message to Haining Zhao at hzz5047@gmail.com.

Inertial effects during irreversible meniscus reconfiguration in angular pores

NASA Astrophysics Data System (ADS)

Ferrari, Andrea; Lunati, Ivan

2014-12-01

interface instabilities that are at the origin of fast pore-scale events, such as Haines jumps, snap-off and coalescence.

Is dietary diversity a proxy measurement of nutrient adequacy in Iranian elderly women?

PubMed

Tavakoli, Sogand; Dorosty-Motlagh, Ahmad Reza; Hoshiar-Rad, Anahita; Eshraghian, Mohamad Reza; Sotoudeh, Gity; Azadbakht, Leila; Karimi, Mehrdad; Jalali-Farahani, Sara

2016-10-01

To investigate whether consumption of more diverse diets would increase the probability of nutrients adequacy among elderly women in Tehran, Iran. This cross-sectional study was conducted on 292 women aged ≥60 years who were randomly selected from 10 public health centers among 31 centers in south area of Tehran. Because of some limitations we randomly chose these 10 centers. The sample sizes provided 80% statistical power to meet the aim of study for test the relationship between Nutrient Adequacy Ratio (NAR), Mean Adequacy Ratio (MAR) as a dependent variable and total Dietary Diversity Score (DDS) as an independent variable. Dietary intakes were assessed by two 24-h recall questionnaires. The mean probability of adequacy across 12 nutrients and energy were calculated using the Dietary Reference Index (DRI). Dietary diversity Score was defined according to diet quality index revised (Haines et al. method). To investigate the relationship between MAR and DDS some demographic and socioeconomic variables were examined. Mean ± SD of total dietary diversity was 4.22 ± 1.28 (range 1.07-6.93). The Fruit and vegetable groups had the highest (1.27 ± 0.65, range 0-2.0) and the lowest (0.56 ± 0.36, range 0-1.71) diversity score, respectively. We observed that total DDS has significant positive correlation with MAR (r = 0.65, P < 0.001). Total DDS was significantly associated with NAR of all 12 studied nutrients (P < 0.01); probability adequacy of vitamin B2 revealed the strongest (r = 0.63, P < 0.01) and vitamin B12 revealed the weakest (r = 0.28, P < 0.01) relationship with total DDS. When maximizing sensitivity and specificity, the best cut-off point for achieving MAR≥1 was 4.5 for DDS. The results of our study showed that DDS is an appropriate indicator of the probability of nutrient adequacy in Tehranian elderly women. Copyright © 2016 Elsevier Ltd. All rights reserved.

Investigation of the Crust of the Pannonian Basin, Hungary Using Low-Altitude CHAMP Horizontal Gradient Magnetic Anomalies

NASA Technical Reports Server (NTRS)

Taylor, Patrick T.; Kis, Karoly I.; Puszta, Sandor; Wittmann, Geza; Kim, Hyung Rae; Toronyi, B.

2011-01-01

The Pannonian Basin is a deep intra-continental basin that formed as part of the Alpine orogeny. It is some 600 by 500 km in area and centered on Hungary. This area was chosen since it has one of the thinnest continental crusts in Europe and is the region of complex tectonic structures. In order to study the nature of the crustal basement we used the long-wavelength magnetic anomalies acquired by the CHAMP satellite. The SWARM constellation, scheduled to be launched next year, will have two lower altitude satellites flying abreast, with a separation of between ca. 150 to 200 km. to record the horizontal magnetic gradient. Since the CHAMP satellite has been in orbit for eight years and has obtained an extensive range of data, both vertically and horizontally there is a large enough data base to compute the horizontal magnetic gradients over the Pannonian Basin region using these many CHAMP orbits. We recomputed a satellite magnetic anomaly map, using the spherical-cap method of Haines (1985), the technique of Alsdorf et al. (1994) and from spherical harmonic coefficients of MF6 (Maus et aI., 2008) employing the latest and lowest altitude CHAMP data. We then computed the horizontal magnetic anomaly gradients (Kis and Puszta, 2006) in order to determine how these component data will improve our interpretation and to preview what the SW ARM mission will reveal with reference to the horizontal gradient anomalies. The gradient amplitude of an 1000 km northeast-southwest profile through our horizontal component anomaly map varied from 0 to 0.025 nT/km with twin positive anomalies (0.025 and 0.023 nT/km) separated by a sharp anomaly negative at o nT/km. Horizontal gradient indicate major magnetization boundaries in the crust (Dole and Jordan, 1978 and Cordell and Grauch, 1985). Our gradient anomaly was modeled with a twodimensional body and the anomaly, of some 200 km, correlates with a 200 km area of crustal thinning in the southwestern Pannonian Basin.

Spatial variability of NDVI at different seasons in the Community of Madrid (Spain)

NASA Astrophysics Data System (ADS)

Sotoca, Juan J. Martin; Saa-Requejo, Antonio; Borondo, Javier; Tarquis, Ana M.

2015-04-01

Agricultural drought quantification is one of the most important tasks in the characterization process of this natural hazard and its implications in crop insurance. Recently, several vegetation indexes based on remote-sensing data (VI) has been applied to quantify it (Dalezios et al, 2012). VIs are obtained combining several frequency bands that represent the relationship between photosynthesis and absorbed/reflected radiation. The most widely used VI is the Normalized Difference Vegetation Index (NDVI). It is based on the principle that healthy vegetation mainly absorbs visible light and reflects the near-infrared frequency band. Drought can be highly localized, and several authors have recognized the critical role of soil moisture and its spatial variability in agricultural losses (Anderson et al., 2011). Therefore, it is important to delimit locations within a homogeneous area that will share main NDVI statistics and in which the same threshold value can be applied to define drought event. In order to do so, we have applied for the first time in this context the method of singularity maps (Cheng and Agterberg, 1996) commonly used in localization of mineral deposits. The NDVI singularity maps calculated in each season through 2011/2012 are showed and discussed (Martín-Sotoca, 2014). References Anderson, M:C:, C. R. Hain, B. Wardlow, J. R. Mecikalski and W. P. Kustas (2011) Evaluation of drought indices based on thermal remote sensing of evapotranspiration over the continental United States. J. Climate, 24, 2025-2044. Dalezios, N.R., A. Blanta, N.V. Spyropoulos and A.M. Tarquis (2012) Risk identification of agricultural drought for sustainable Agroecosystems. Nat. Hazards Earth Syst. Sci., 14, 2435-2448. Cheng, Q. and F.P. Agterberg (1996) Multifractal modeling and spatial statistics. Math. Geol., 28, 1-16. Martín-Sotoca, J.J. (2014) Estructura Espacial de la Sequía en Pastos y sus Aplicaciones en el Seguro Agrario. Master Thesis, UPM (In Spanish

Rugged Energy Landscapes in Multiphase Porous Media Flow: A Discrete-Domain Description

NASA Astrophysics Data System (ADS)

Cueto-Felgueroso, L.; Juanes, R.

2015-12-01

Immiscible displacements in porous media involve a complex sequence of pore-scale events, from the smooth, reversible displacement of interfaces to abrupt interfacial reconfigurations and rapid pore invasion cascades. Discontinuous changes in pressure or saturation have been referred to as Haines jumps, and they emerge as a key mechanism to understand the origin of hysteresis in porous media flow. Hysteresis persists at the many-pore scale: when multiple cycles of drainage and imbibition of a porous sample are conducted, a dense hysteresis diagram emerges. The interpretation of hysteresis as a consequence of irreversible transitions and multistability is at the heart of early hysteresis models, and in recent experiments, and points to an inherently non-equilibrium behavior. For a given volume fraction of fluids occupying the pore space, many stable configurations are possible, due to the tortuous network of nonuniform pores and throats that compose the porous medium, and to complex wetting and capillary transitions. Multistability indicates that porous media systems exhibit rugged energy landscapes, where the system may remain pinned at local energy minima for long times. We address the question of developing a zero-dimensional model that inherits the path-dependence and `'bursty'' behavior of immiscible displacements, and propose a discrete-domain model that captures the role of metastability and local equilibria in the origin of hysteresis. We describe the porous medium and fluid system as a discrete set of weakly connected, multistable compartments, charaterized by a unique free energy function. This description does not depend explicitly on past saturations, turning points, or drainage/imbibition labels. The system behaves hysteretically, and we rationalize its behavior as sweeping a complex metastability diagram, with dissipation arising from discrete switches among metastable branches. The hysteretic behavior of the pressure-saturation curve is controlled by

Treatment initiation among persons diagnosed with drug resistant tuberculosis in Johannesburg, South Africa

PubMed Central

Schnippel, Kathryn; Govathson, Caroline; Sineke, Tembeka; Black, Andrew; Long, Lawrence; Berhanu, Rebecca; Rosen, Sydney

2017-01-01

Background In South Africa, roughly half of the drug-resistant TB cases diagnosed are reported to have been started on treatment. We determined the proportion of persons diagnosed with rifampicin resistant (RR-) TB who initiated treatment in Johannesburg after the introduction of decentralized RR-TB care in 2011. Methods We retrospectively matched adult patients diagnosed with laboratory-confirmed RR-TB in Johannesburg from 07/2011-06/2012 with records of patients initiating RR-TB treatment at one of the city’s four public sector treatment sites (one centralized, three decentralized). Patients were followed from date of diagnosis until the earliest of RR-TB treatment initiation, death, or 6 months’ follow-up. We report diagnostic methods and outcomes, proportions initiating treatment, and median time from diagnosis to treatment initiation. Results 594 patients were enrolled (median age 34 (IQR 29–42), 287 (48.3%) female). Diagnosis was by GenoType MTBDRplus (Hain-Life-Science) line probe assay (LPA) (281, 47.3%), Xpert MTB/RIF (Cepheid) (258, 43.4%), or phenotypic drug susceptibility testing (DST) (30, 5.1%) with 25 (4.2%) missing a diagnosis method. 320 patients (53.8%) had multi-drug resistant TB, 158 (26.6%) rifampicin resistant TB by Xpert MTB/RIF, 102 (17.2%) rifampicin mono-resistance, and 14 (2.4%) extensively drug-resistant TB. 256/594 (43.0%) patients initiated treatment, representing 70.7% of those who were referred for treatment (362/594). 338/594 patients (57.0%) did not initiate treatment, including 104 (17.5%) who died before treatment was started. The median time from sputum collection to treatment initiation was 33 days (IQR 12–52). Conclusion Despite decentralized RR-TB treatment, fewer than half the patients diagnosed in Johannesburg initiated appropriate treatment. Offering treatment at decentralized sites alone is not sufficient; improvements in linking patients diagnosed with RR-TB to effective treatment is essential. PMID:28746344

The Role of Long-Term Tectonic Deformation on the Distribution of Present-Day Seismic Activity in the Caribbean and Central America

NASA Astrophysics Data System (ADS)

Schobelock, J.; Stamps, D. S.; Pagani, M.; Garcia, J.; Styron, R. H.

2017-12-01

The Caribbean and Central America region (CCAR) undergoes the entire spectrum of earthquake types due to its complex tectonic setting comprised of transform zones, young oceanic spreading ridges, and subductions along its eastern and western boundaries. CCAR is, therefore, an ideal setting in which to study the impacts of long-term tectonic deformation on the distribution of present-day seismic activity. In this work, we develop a continuous tectonic strain rate model based on inter-seismic geodetic data and compare it with known active faults and earthquake focal mechanism data. We first create a 0.25o x 0.25o finite element mesh that is comprised of block geometries defined in previously studies. Second, we isolate and remove transient signals from the latest open access community velocity solution from UNAVCO, which includes 339 velocities from COCONet and TLALOCNet GNSS data for the Caribbean and Central America, respectively. In a third step we define zones of deformation and rigidity by creating a buffer around the boundary of each block that varies depending on the size of the block and the expected deformation zone based on locations of GNSS data that are consistent with rigid block motion. We then assign each node within the buffer a 0 for the deforming areas and a plate index outside the buffer for the rigid. Finally, we calculate a tectonic strain rate model for CCAR using the Haines and Holt finite element approach to fit bi-cubic Bessel splines to the the GNSS/GPS data assuming block rotation for zones of rigidity. Our model of the CCAR is consistent with compression along subduction zones, extension across the mid-Pacific Rise, and a combination of compression and extension across the North America - Caribbean plate boundary. The majority of CCAR strain rate magnitudes range from -60 to 60 nanostrains/yr. Modeling results are then used to calculate expected faulting behaviors that we compare with mapped geologic faults and seismic activity.

Lattice Boltzmann simulations of liquid CO2 displacing water in a 2D heterogeneous micromodel at reservoir pressure conditions.

PubMed

Chen, Yu; Li, Yaofa; Valocchi, Albert J; Christensen, Kenneth T

2018-05-01

We employed the color-fluid lattice Boltzmann multiphase model to simulate liquid CO 2 displacing water documented in experiments in a 2D heterogeneous micromodel at reservoir pressure conditions. The main purpose is to investigate whether lattice Boltzmann simulation can reproduce the CO 2 invasion patterns observed in these experiments for a range of capillary numbers. Although the viscosity ratio used in the simulation matches the experimental conditions, the viscosity of the fluids in the simulation is higher than that of the actual fluids used in the experiments. Doing so is required to enhance numerical stability, and is a common strategy employed in the literature when using the lattice Boltzmann method to simulate CO 2 displacing water. The simulations reproduce qualitatively similar trends of changes in invasion patterns as the capillary number is increased. However, the development of secondary CO 2 pathways, a key feature of the invasion patterns in the simulations and experiments, is found to occur at a much higher capillary number in the simulations compared with the experiments. Additional numerical simulations were conducted to investigate the effect of the absolute value of viscosity on the invasion patterns while maintaining the viscosity ratio and capillary number fixed. These results indicate that the use of a high viscosity (which significantly reduces the inertial effect in the simulations) suppresses the development of secondary CO 2 pathways, leading to a different fluid distribution compared with corresponding experiments at the same capillary number. Therefore, inertial effects are not negligible in drainage process with liquid CO 2 and water despite the low Reynolds number based on the average velocity, as the local velocity can be much higher due to Haines jump events. These higher velocities, coupled with the low viscosity of CO 2 , further amplifies the inertial effect. Therefore, we conclude that caution should be taken when using

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.

PubMed

Maningi, Nontuthuko E; Daum, Luke T; Rodriguez, John D; Said, Halima M; Peters, Remco P H; Sekyere, John Osei; Fischer, Gerald W; Chambers, James P; Fourie, P Bernard

2018-05-01

Modern advances in genomics provide an opportunity to reinterpret historical bacterial culture collections. In this study, genotypic antibiotic resistance profiles of Mycobacterium tuberculosis isolates from a historical 20-year-old multidrug-resistant tuberculosis (MDR-TB) culture collection in South Africa are described. DNA samples extracted from the phenotypically MDR-TB isolates ( n = 240) were assayed by Hain line probe assay (LPA) for the confirmation of MDR-TB and by Illumina Miseq whole-genome sequencing (WGS) for the characterization of mutations in eight genes ( rpoB , katG , inhA , rpsL , pncA , embB , gyrA , and rrs ) that are known to code for resistance to commonly used anti-TB agents. LPA identified 71.3% of the TB isolates as MDR-TB, 18.3% as rifampin (RIF) monoresistant, 2% as isoniazid (INH) monoresistant, and 8.3% as susceptible to both RIF and INH (RIF+INH). In a subset of 42 randomly selected isolates designated as RIF+INH resistant by Löwenstein-Jensen (LJ) culture in 1993, LPA and WGS results confirmed MDR-TB. In all five INH-monoresistant isolates by LPA and in all but one (the wild type) of the 34 successfully sequenced RIF-monoresistant isolates, WGS revealed matching mutations. Only 26% of isolates designated as susceptible by LPA, however, were found to be wild type by WGS. Novel mutations were found in the rpoB (Thr480Ala, Gln253Arg, Val249Met, Val251Tyr, Val251Phe), katG (Trp477STOP, Gln88STOP, Trp198STOP, Trp412STOP), embB (Thr11Xaa, Gln59Pro), and pncA (Thr100Ile, Thr159Ala, Ala134Arg, Val163Ala, Thr153Ile, DelGpos7, Phe106Ser) genes. Three MDR-TB isolates showed mutations in both the gyrA and rrs genes, suggesting that extensively drug-resistant tuberculosis existed in South Africa well before its formal recognition in 2006. Copyright © 2018 American Society for Microbiology.

Crustal and Upper Mantle Structure of the Taupo Volcanic Zone, North Island, New Zealand.

NASA Astrophysics Data System (ADS)

Harrison, A. J.; White, R. S.

2003-12-01

The Taupo Volcanic Zone (TVZ) is a major Pliocene-Quaternary NNE-SSW orientated,volcano-tectonic complex, about 250 km long and up to 60 km wide in the central North Island of New Zealand. The TVZ is one of the largest and most frequently active rhyolitic magmatic systems on Earth, characterised by intense shallow seismic activity, high natural heat flow (some 12-20 times the continental norm) and active NW-SE extension. To the north of the TVZ, subduction of the Pacific Plate beneath the oceanic lithosphere of the Australian Plate is accompanied by a region of back-arc extension (the Havre Trough). The TVZ marks the southern continuation of this back-arc extension into continental lithosphere.The TVZ therefore represents an ideal opportunity to study the onset of back-arc spreading onshore. Here we present forward and inverse models of the crustal structure beneath the TVZ. These models incorporate both active and passive source data acquired from the NIGHT (North Island GeopHysical Transect) project. Common to both models is a 2-3km deep basin of low velocity sediments which we interpret to be ignimbrite deposits. Typical basement velocities of ˜6km/s are observed beneath and to either side of the TVZ, where they correlate well with mapped outcrops of basement rocks. Velocities of around 7.3 km/s are observed at depths greater than 16 km beneath the TVZ. Such velocities may be interpreted as anomalously low velocity upper manlte or heavly intruded lower crust. Having constrained the crustal structure we then use earthquake events from the subducting Pacific Plate to yield information on the velocity structure of the upper mantle beneath the TVZ. NIGHT Working Group A. Harrison, J. Haines, R. White (University of Cambridge,United Kingdom); S. Henrys, S. Bannister, I. Pecher, F. Davey (Inst. Geological and Nuclear Sciences, Lower Hutt, New Zealand); T. Stern, W. Stratford (Victoria University of Wellington, New Zealand); H. Shimamura, Y. Nishimura, and A. Yamada

Estimating the Health Effects of Greenhouse Gas Mitigation Strategies: Addressing Parametric, Model, and Valuation Challenges

PubMed Central

Hess, Jeremy J.; Ebi, Kristie L.; Markandya, Anil; Balbus, John M.; Wilkinson, Paul; Haines, Andy; Chalabi, Zaid

2014-01-01

simultaneously improving health. Citation: Remais JV, Hess JJ, Ebi KL, Markandya A, Balbus JM, Wilkinson P, Haines A, Chalabi Z. 2014. Estimating the health effects of greenhouse gas mitigation strategies: addressing parametric, model, and valuation challenges. Environ Health Perspect 122:447–455; http://dx.doi.org/10.1289/ehp.1306744 PMID:24583270

Comparative evaluation of the identification of rapidly growing non-tuberculous mycobacteria by mass spectrometry (MALDI-TOF MS), GenoType Mycobacterium CM/AS assay and partial sequencing of the rpoβ gene with phylogenetic analysis as a reference method.

PubMed

Costa-Alcalde, José Javier; Barbeito-Castiñeiras, Gema; González-Alba, José María; Aguilera, Antonio; Galán, Juan Carlos; Pérez-Del-Molino, María Luisa

2018-06-02

The American Thoracic Society and the Infectious Diseases Society of America recommend that clinically significant non-tuberculous mycobacteria (NTM) should be identified to the species level in order to determine their clinical significance. The aim of this study was to evaluate identification of rapidly growing NTM (RGM) isolated from clinical samples by using MALDI-TOF MS and a commercial molecular system. The results were compared with identification using a reference method. We included 46 clinical isolates of RGM and identified them using the commercial molecular system GenoType ® CM/AS (Hain, Lifescience, Germany), MALDI-TOF MS (Bruker) and, as reference method, partial rpoβ gene sequencing followed by BLAST and phylogenetic analysis with the 1093 sequences available in the GeneBank. The degree of agreement between GenoType ® and MALDI-TOF MS and the reference method, partial rpoβ sequencing, was 27/43 (62.8%) and 38/43 cases (88.3%) respectively. For all the samples correctly classified by GenoType ® , we obtained the same result with MALDI-TOF MS (27/27). However, MALDI-TOF MS also correctly identified 68.75% (11/16) of the samples that GenoType ® had misclassified (p=0.005). MALDI-TOF MS classified significantly better than GenoType ® . When a MALDI-TOF MS score >1.85 was achieved, MALDI-TOF MS and partial rpoβ gene sequencing were equivalent. GenoType ® was not able to distinguish between species belonging to the M. fortuitum complex. MALDI-TOF MS methodology is simple, rapid and associated with lower consumable costs than GenoType ® . The partial rpoβ sequencing methods with BLAST and phylogenetic analysis were not able to identify some RGM unequivocally. Therefore, sequencing of additional regions would be indicated in these cases. Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Secular decline of seawater calcium increases seawater buffering and pH

NASA Astrophysics Data System (ADS)

Hain, M.; Sigman, D. M.; Higgins, J. A.; Haug, G. H.

2015-12-01

Reconstructed changes in seawater calcium and magnesium concentration ([Ca2+], [Mg2+]) predictably affect the ocean's acid/base and carbon chemistry. Yet inaccurate formulations of chemical equilibrium "constants" are currently in use to account for these changes. Here we develop an efficient implementation of the MIAMI Ionic Interaction Model (Millero and Pierrot, 1998) to predict all chemical equilibrium constants required for carbon chemistry calculations under variable [Ca2+] and [Mg2+] (Hain et al., 2015). We investigate the impact of [Ca2+] and [Mg2+] on the relationships among the ocean's pH, CO2, dissolved inorganic carbon (DIC), saturation state of CaCO3 (Ω), and buffer capacity. Increasing [Ca2+] and/or [Mg2+] enhances "ion pairing," which increases seawater buffering by increasing the concentration ratio of total to "free" (uncomplexed) carbonate ion. An increase in [Ca2+], however, also causes a decline in carbonate ion to maintain a given Ω, thereby overwhelming the ion pairing effect and decreasing seawater buffering. Given the reconstructions of Eocene [Ca2+] and [Mg2+] ([Ca2+]~20mM; [Mg2+]~30 mM), Eocene seawater would have required essentially the same DIC as today to simultaneously explain a similar-to-modern Ω and the estimated Eocene atmospheric CO2 of ~1000 ppm. During the Cretaceous, at ~4 times modern [Ca2+], ocean buffering would have been at a minimum. Overall, during times of high seawater [Ca2+], CaCO3 saturation, pH, and atmospheric CO2 were more susceptible to perturbations of the global carbon cycle. For example, given both Eocene and Cretaceous seawater [Ca2+] and [Mg2+], a doubling of atmospheric CO2 would require less carbon addition to the ocean/atmosphere system than under modern seawater composition. Moreover, increase in seawater buffering since the Cretaceous may have been a driver of evolution by raising energetic demands of biologically controlled calcification and CO2 concentration mechanisms that aid photosynthesis.

Incremental fold tests of remagnetized carbonate rocks

NASA Astrophysics Data System (ADS)

Van Der Voo, R.; van der Pluijm, B.

2017-12-01

Many unmetamorphosed carbonates all over the world are demonstrably remagnetized, with the age of the secondary magnetizations typically close to that of the nearest orogeny in space and time. This observation did not become compelling until the mid-1980's, when the incremental fold test revealed the Appalachian carbonates to carry a syn-deformational remanence of likely Permian age (Scotese et al., 1982, Phys. Earth Planet. Int., v. 30, p. 385-395; Cederquist et al., 2006, Tectonophysics v. 422, p. 41-54). Since that time scores of Appalachian and Rocky Mountain carbonate rocks have added results to the growing database of paleopoles representing remagnetizations. Late Paleozoic remagnetizations form a cloud of results surrounding the reference poles of the Laurentian APWP. Remagnetizations in other locales and with inferred ages coeval with regional orogenies (e.g., Taconic, Sevier/Laramide, Variscan, Indosinian) are also ubiquitous. To be able to transform this cornucopia into valuable anchor-points on the APWP would be highly desirable. This may indeed become feasible, as will be explained next. Recent studies of faulted and folded carbonate-shale sequences have shown that this deformation enhances the illitization of smectite (Haines & van der Pluijm, 2008, Jour. Struct. Geol., v. 30, p. 525-538; Fitz-Diaz et al., 2014, International Geol. Review, v. 56, p. 734-755). 39Ar-40Ar dating of the authigenic illite (neutralizing any detrital illite contribution by taking the intercept of a mixing line) yields, therefore, the age of the deformation. We know that this date is also the age of the syndeformational remanence; thus we have the age of the corresponding paleopole. Results so far are obtained for the Canadian and U.S. Rocky Mountains and for the Spanish Cantabrian carbonates (Tohver et al., 2008, Earth Planet. Sci. Lett., v. 274, p. 524-530) and make good sense in accord with geological knowledge. Incremental fold tests are the tools used for this

Liquid redistribution behind a drainage front in porous media imaged by neutron radiography

NASA Astrophysics Data System (ADS)

Hoogland, Frouke; Lehmann, Peter; Moebius, Franziska; Vontobel, Peter; Or, Dani

2013-04-01

Drainage from porous media is a highly dynamic process involving the motion of a displacement front with rapid pore scale interfacial jumps and phase entrapment, but also a more gradual host of liquid redistribution processes in the unsaturated region behind the front. Depending on the velocity of the drainage process, liquid properties and the permeability of the porous medium, redistribution lingers long after the main drainage process is stopped, until gravity and capillary forces regain equilibrium. The rapid and often highly inertial Haines jumps at the drainage front challenge the validity of Buckingham-Darcy law and thus representation of the process based on the foundation of Richards equation. To quantify front displacement and liquid reconfiguration and to test validity of Richards equation with respect to fast drainage dynamics, we carried out drainage experiments by withdrawing water from the bottom of initially saturated sand-filled Hele-Shaw cells at constant water flux (2.6 or 13.1 mm/minute). Water content distribution and evolution of drainage front were measured with neutron radiography at spatial and temporal resolutions of 0.1 mm and 3 seconds, respectively. Water pressure was measured above and below the front using pressure transducers and a tensiometer. After the pump was stopped (at a front depth around 100 mm), capillary pressure values in the unsaturated region (above the front) gradually converged to a new equilibrium. The pressure signal in the saturated region below the front reflected viscous losses during flow that were relaxed when the pump stopped. During pressure relaxation water was redistributed primarily downward in the unsaturated region. Pressure signals and dynamics of water content profiles for fast process (13.6 mm/minute) could not be reproduced with Richards equation based on hydraulic functions determined in preceding laboratory experiments. To explore if the deviations stem from inappropriate hydraulic functions we

How Do Apps Work? An Analysis of Physical Activity App Users' Perceptions of Behavior Change Mechanisms.

PubMed

Hoj, Taylor H; Covey, Emarie L; Jones, Allyn C; Haines, Amanda C; Hall, P Cougar; Crookston, Benjamin T; West, Joshua H

2017-08-03

others wishing to increase levels of physical activity. ©Taylor H Hoj, Emarie L Covey, Allyn C Jones, Amanda C Haines, P Cougar Hall, Benjamin T Crookston, Joshua H West. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 03.08.2017.

Gym-based exercise was more costly compared with home-based exercise with telephone support when used as maintenance programs for adults with chronic health conditions: cost-effectiveness analysis of a randomised trial.

PubMed

Jansons, Paul; Robins, Lauren; O'Brien, Lisa; Haines, Terry

2018-01-01

What is the comparative cost-effectiveness of a gym-based maintenance exercise program versus a home-based maintenance program with telephone support for adults with chronic health conditions who have previously completed a short-term, supervised group exercise program? A randomised, controlled trial with blinded outcome assessment at baseline and at 3, 6, 9 and 12 months. The economic evaluation took the form of a trial-based, comparative, incremental cost-utility analysis undertaken from a societal perspective with a 12-month time horizon. People with chronic health conditions who had completed a 6-week exercise program at a community health service. One group of participants received a gym-based exercise program and health coaching for 12 months. The other group received a home-based exercise program and health coaching for 12 months with telephone follow-up for the first 10 weeks. Healthcare costs were collected from government databases and participant self-report, productivity costs from self-report, and health utility was measured using the European Quality of Life Instrument (EQ-5D-3L). Of the 105 participants included in this trial, 100 provided sufficient cost and utility measurements to enable inclusion in the economic analyses. Gym-based follow-up would cost an additional AUD491,572 from a societal perspective to gain 1 quality-adjusted life year or 1year gained in perfect health compared with the home-based approach. There was considerable uncertainty in this finding, in that there was a 37% probability that the home-based approach was both less costly and more effective than the gym-based approach. The gym-based approach was more costly than the home-based maintenance intervention with telephone support. The uncertainty of these findings suggests that if either intervention is already established in a community setting, then the other intervention is unlikely to replace it efficiently. ACTRN12610001035011. [Jansons P, Robins L, O'Brien L, Haines T

Wavelet-Domain Nonlinear Energy and Enstrophy Transfers between Atmospheric Blocks and Local Eddies, Averaged over the NCEP Reanalysis

NASA Astrophysics Data System (ADS)

Fournier, A.

2001-05-01

There is reason to believe that weather is more predictable during atmospheric blocking (AB) events than during ``normal'' (N) meteorological states (Bengtsson 1981). Saltzman (1959) proposed that such quasi-permanent disturbances in general may be maintained by an up-scale nonlinear eddy kinetic energy (KE) cascade. This idea was later applied to or verified for AB observations or models by Green (1970,1977), Hansen & Chen (1982), Shutts (1983,1986), Haines & Marshall (1987), Butchart et al. (1989), Riyu & Ronghui (1996), Nakamura et al. (1997) and others. We present a study of the nonlinear-energetics contrast between Atlantic (A) and Pacific (P) AB and N, generalizing the Fourier-based approach originated by Saltzman (1957) and Hansen & Sutera (1984). The Wavelet Energetics (WE) recently introduced by the author is applied to the 53-y NCEP Reanalyis, extending his study of AB presented in AGU, 1995 and (Fournier 1998,1999,2000). Temporal mean and variance maps suggest that AB is associated with eddy activity concentrated on smaller scales on either side of the AB ridge. Correlating WE, AB relative to nonblocking, illumenates the AB similarities and differences between P and A, as the former's WE pattern is shifted over the latter's. The theoretical conservation of Wavelet Flux is numerically verified to well below observational tolerance. Statistical significance is estimated. Conclusions include the following. Wavelet KE and enstrophy stocks (localized at scale ≈21-jπ r⊕ cosǎrphi, zonal-wavenumber band ≈ ]2j-1,2j] and longitude ≈21-jkπ ) Kjk and Ejk increase upstream, decrease downstream of either block. Mean-flow transfer MKjk increases downstream, at j=2 (and j=4 for A, 5 for P). Eddy transfer TKjk has more complex changes, A!=qP except that TK1k decreases downstream. Eddy flux FKjk shows downscale (upscale) cascade downstream (upstream) of P (A blocks tend to migrate in λ more than do P, that would weaken this signal for A). MEjk and TEjk have

A review of seismoelectric data processing techniques

NASA Astrophysics Data System (ADS)

Warden, S. D.; Garambois, S.; Jouniaux, L.; Sailhac, P.

2011-12-01

Seismoelectric tomography is expected to combine the sensitivity of electromagnetic methods to hydrological properties such as water-content and permeability, to the high resolution of conventional seismic surveys. This innovative exploration technique seems very promising as it could characterize the fluids contained in reservoir rocks and detect thin layers invisible to other methods. However, it still needs to be improved before it can be successfully applied to real case problems. One of the main issues that need to be addressed is the development of wave separation techniques enabling to recover the signal of interest. Seismic waves passing through a fluid-saturated porous layered medium convert into at least two types of electromagnetic waves: the coseismic field (type I), accompanying seismic body and surface waves, and the independently propagating interface response (type II). The latter occurs when compressional waves encounter a contrast between electrical, chemical or mechanical properties in the subsurface, thus acting as a secondary source that can be generally approximated by a sum of electrical dipoles oscillating at the first Fresnel zone. Although properties of the medium in the vicinity of the receivers can be extracted from the coseismic waves, only the interface response provides subsurface information at depth, which makes it critical to separate both types of energy. This is a delicate problem, as the interface response may be several orders of magnitude weaker than the coseismic field. However, as reviewed by Haines et al. (2007), several properties of the interface response can be used to identify it: its dipolar amplitude pattern, its opposite polarity on opposite sides of the shot point and the electromagnetic velocity at which it travels, several orders of magnitude greater than seismic velocities. This latter attribute can be exploited to implement filtering techniques in frequency-wavenumber (f-k) and radon (tau-p) domain, which we

Lessons for climate policy from The Great Stink of London

NASA Astrophysics Data System (ADS)

Skuce, A.

2012-12-01

different kind may have to be raised in the world's capitals before effective action begins on the much more challenging problem of climate change. References Alley, R. B., Haines-Stiles, G., Akuginow, E., 2010. Toilets and the Smart Grid: A role for history and art in communicating assessed science for Earth—The Operators' Manual. AGU, Fall Meeting 2010, abstract #ED41D-05. Alley, R.B., 2011. EARTH: The Operators' Manual. W.W. Norton & Company. ISBN 978-0-393-08109-1 Gardiner, S.H., 2011. A Perfect Moral Storm: The Ethical Tragedy of Climate Change. Oxford University Press. ISBN13: 9780195379440 Halliday, S. 1999. The Great Stink of London: Sir Joseph Bazalgette and the Cleansing of the Victorian Capital. Sutton Publishing Limited. ISBN 0-7509-1975-2

Rapidly Deglaciating and Uplifting Landscapes in Glacier Bay National Park and Preserve GBNPP Provide Alaskan High School Students with Summer Field Research Experiences in Paleoclimate Disciplines and Exposure to Active Researchers in Synergistic Sciences

NASA Astrophysics Data System (ADS)

Connor, C. L.; Hekkers, M.; Schaller, S.; Parks, R.

2011-12-01

During summer 2011, ten Alaska high school students enrolled in a summer college introductory field science course through the Design Discover Research Program (DDR) at University Alaska Southeast, with support from the Juneau Economic Development Council, the University Alaska Fairbanks Alaska Summer Research Academy (ASRA), the National Park Service, and the National Oceanic and Atmospheric Administration (NOAA)-Interdisciplinary Scientific Environmental Technology (ISET) Cooperative Science Center (CSC). They conducted field surveys in Glacier Bay National Park and across the adjacent Gustavus glacier forefield landscape. This was the 4th summer for this program. Following a 2-1/2 day orientation on the UAS campus, students traveled by a newly established (2011) Alaska Marine Highway service from Juneau to Gustavus. They utilized bicycles and hiking to access the Dude Creek Critical Habitat, Good Creek watershed, and the Nagoonberry Trail built by the Nature Conservancy along the emerging shoreline of Icy Strait. This region is currently experiencing uplift rates of 20-28 mm/year as a result of Little Ice Age deglaciation and isostatic rebound, rates much higher than eustatic sea level rise. North of the Gustavus ferry dock, roughly 19 acres of emergent land is now a 9-hole golf course, raised from the sea since the 1950s. DDR-students interacted with wildlife biologists, ornithologists, quaternary geologists, glaciologists, and botanists to integrate their understanding of the response of plants and animals to this dynamic landscape. Radio-collared moose populations, which migrated into this area from Haines since the mind-1960s, are being studied to asses their impacts to local vegetation and the behavior of local predators (bears, wolves, and coyotes). Sitka spruce forest expansion onto Icy Strait uplifting salt marshes, now threaten Sandhill Crane habitat and their flyover stops along the Pacific Flyway. Intertidal areas in Bartlett Cove in GBNPP feature

PREFACE: XII Latin American workshop on plasma physics (17-21 September 2007, Caracas, Venezuela)

NASA Astrophysics Data System (ADS)

Puerta, Julio

2008-10-01

Deutsch, Ricardo Galvao, Carlos Hidalgo, Paulo Sakanaka, Konosuke Sato, Malcom Haines and Maher Boulos. The general feeling is that these mini-courses were very successful. As an original idea of Professor Ricardo Magnus Osorio Galvão, Director of Centro Brasileiro de Pesquisas Físicas, we saluted the creation of The Vladimir Tsypin Award to the best Poster in the meeting. This prize was presented by Professor Galvão in memoriam of Vladimir Semenovich Tsypin. It was suggested that the granting of this award be made in every meeting from now on. We think that it is very important to emphasise the mini-courses due to the necessity of increasing in the near future a better formation for our young scientists. The contributions of all the lecturers are greatly appreciated. We had the typical fields in plasma physics as in past meetings. We also appreciated very much the lectures of Professor Malcolm Haines, Professor Sergey Popel, Professor Claude Deutsch, and Professor Antony Peratt for their very interesting talks on the Z-Pinch recorded to prehistory. Special thanks again to these lecturers since they have joined and honoured our meetings in the past as well. As in the VII LAWPP, all the sessions of the workshop were held at the Universidad Simon Bolivar campus, located in the nice green Valley of Sartenejas near Caracas. We also appreciate the stimulus and the financial support that we have always had for the preparation of these workshops from our institution by means of its authorities: Professor Benjamin Sharifker (Rector), Professor Aura Lopez (Dean of Academic Activities), (Professor Jose Luis Paz (Dean of Research and Development), Professor Pedro Berrisbeitia (Dean of Postgraduate Studies) and Professor William Colmenares (Dean of Extended Activities). We must also mention and appreciate the collaboration of architect Alejandro Chataing Roncajolo as Secretary and Coordinator of the Congress, as well as the daily important collaborations of our students Anais M�

[Tuberculosis Laboratory Surveillance Network (TuLSA) study group. The first step for national tuberculosis laboratory surveillance: Ankara, 2011].

PubMed

Sezen, Figen; Albayrak, Nurhan; Özkara, Şeref; Karagöz, Alper; Alp, Alpaslan; Duyar Ağca, Filiz; İnan Süer, Asiye; Müderris, Tuba; Ceyhan, İsmail; Durmaz, Rıza; Ertek, Mustafa

2015-04-01

The most effective method for monitoring country-level drug resistance frequency and to implement the necessary control measures is the establishment of a laboratory-based surveillance system. The aim of this study was to summarize the follow up trend of the drug-resistant tuberculosis (TB) cases, determine the load of resistance and evaluate the capacities of laboratories depending on laboratory quality assurance system for the installation work of National Tuberculosis Laboratory Surveillance Network (TuLSA) which has started in Ankara in 2011. TuLSA studies was carried out under the coordination of National Tuberculosis Reference Laboratory (NRL) with the participation of TB laboratories and dispensaries. Specimens of TB patients, reported from health institutions, were followed in TB laboratories, and the epidemiological information was collected from the dispensaries. One isolate per patient with the drug susceptibility test (DST) results were sent to NRL from TB laboratories and in NRL the isolates were rechecked with the genotypical (MTBDRplus, Hain Lifescience, Germany) and phenotypical (MGIT 960, BD, USA) DST methods. Molecular epidemiological analysis were also performed by spoligotyping and MIRU/VNTR. Second-line DST was applied to the isolates resistant to rifampin. A total of 1276 patients were reported between January 1st to December 31th 2011, and 335 cases were defined as "pulmonary TB from Ankara province". The mean age of those patients was 43.4 ± 20 years, and 67.5% were male. Three hundred seventeen (94.6%) patients were identified as new cases. The average sample number obtained from pulmonary TB cases was 3.26 ± 2.88, and 229 (68.3%) of them was culture positive. DST was applied to all culture positive isolates; 90.4% (207/229) of cases were susceptible to the five drugs tested (ethambutol, isoniazid, pyrazinamide, rifampicin, streptomycin). Eight (3.5%) of the isolates were multidrug-resistant (MDR-TB), while no extensively drug

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.

PubMed

Talmud, Philippa J; Shah, Sonia; Whittall, Ros; Futema, Marta; Howard, Philip; Cooper, Jackie A; Harrison, Seamus C; Li, Kawah; Drenos, Fotios; Karpe, Frederik; Neil, H Andrew W; Descamps, Olivier S; Langenberg, Claudia; Lench, Nicholas; Kivimaki, Mika; Whittaker, John; Hingorani, Aroon D; Kumari, Meena; Humphries, Steve E

2013-04-13

Familial hypercholesterolaemia is a common autosomal-dominant disorder caused by mutations in three known genes. DNA-based cascade testing is recommended by UK guidelines to identify affected relatives; however, about 60% of patients are mutation-negative. We assessed the hypothesis that familial hypercholesterolaemia can also be caused by an accumulation of common small-effect LDL-C-raising alleles. In November, 2011, we assembled a sample of patients with familial hypercholesterolaemia from three UK-based sources and compared them with a healthy control sample from the UK Whitehall II (WHII) study. We also studied patients from a Belgian lipid clinic (Hôpital de Jolimont, Haine St-Paul, Belgium) for validation analyses. We genotyped participants for 12 common LDL-C-raising alleles identified by the Global Lipid Genetics Consortium and constructed a weighted LDL-C-raising gene score. We compared the gene score distribution among patients with familial hypercholesterolaemia with no confirmed mutation, those with an identified mutation, and controls from WHII. We recruited 321 mutation-negative UK patients (451 Belgian), 319 mutation-positive UK patients (273 Belgian), and 3020 controls from WHII. The mean weighted LDL-C gene score of the WHII participants (0.90 [SD 0.23]) was strongly associated with LDL-C concentration (p=1.4 x 10(-77); R(2)=0.11). Mutation-negative UK patients had a significantly higher mean weighted LDL-C score (1.0 [SD 0.21]) than did WHII controls (p=4.5 x 10(-16)), as did the mutation-negative Belgian patients (0.99 [0.19]; p=5.2 x 10(-20)). The score was also higher in UK (0.95 [0.20]; p=1.6 x 10(-5)) and Belgian (0.92 [0.20]; p=0.04) mutation-positive patients than in WHII controls. 167 (52%) of 321 mutation-negative UK patients had a score within the top three deciles of the WHII weighted LDL-C gene score distribution, and only 35 (11%) fell within the lowest three deciles. In a substantial proportion of patients with

New insights on the seismic hazard in the Balkans inferred from GPS

NASA Astrophysics Data System (ADS)

D'Agostino, Nicola; Métois, Marianne; Avallone, Antonio; Chamot-Rooke, Nicolas

2014-05-01

associated seismic hazard of the Balkan region. We processed all the currently available data acquired on these new networks using the precise point positioning strategy of the Gipsy-Oasis software (Bertiger et al. 2010) and the daily ITF2008 transformation parameters (x-files) from JPL. Daily coordinates are obtained in a Eurasia-fix reference frame obtained using the strategy developed by Blewitt et al. (2012). Here we present this new velocity field combined with previously published data sets covering the Balkan Peninsula. This unusually dense picture of the current deformation, in particular in Slovenia and Serbia, enables us to derive a continuous map of the strain rate over the region using the approach of Haines and Holt (1993). We then derive the seismogenic potential of the region combining the geodetic strain rate and the available regional CMT moment tensor solutions. These maps bring new insights on areas of significant strain accumulation over the Balkan Peninsula and are a first step to better assess seismic hazard there.

A New Global Geodetic Strain Rate Model

NASA Astrophysics Data System (ADS)

Kreemer, C.; Blewitt, G.; Klein, E. C.; Shen, Z.; Wang, M.; Estey, L.; Wier, S.

2013-12-01

As part of the Global Earthquake Model (GEM) effort to improve global seismic hazard models, we present a new global geodetic strain rate model. This model (GSRM v. 2) is a vast improvement on the previous model from 2004 (v. 1.2). The model is still based on a finite-element type approach and has deforming cells in between the assumed rigid plates. The new model contains ~144,700 cells of 0.25° by 0.2° dimension. We redefined the geometries of the deforming zones based on the definitions of Bird (2003) and Chamot-Rooke and Rabaute (2006). We made some adjustments to the grid geometry at places where seismicity and/or GPS velocities suggested either the presence of deforming areas or a rigid block where those previous studies did not. GSRM v.2 includes 50 plates and blocks, including many not considered by Bird (2003). The new GSRM model is based on over 20,700 horizontal geodetic velocities at over 17,000 unique locations. The GPS velocity field consists of a 1) Over 6500 velocities derived by the University of Nevada, Reno, for CGPS stations for which >2.5 years of RINEX data are available until April 2013, 2) ~1200 velocities for China from a new analysis of all data from the Crustal Movement Network of China (CMONOC), and 3) about 13,000 velocities from 212 studies published in the literature or made otherwise available to us. Velocities from all studies were combined into the same reference frame by a 6-parameter transformation using velocities at collocated stations. We model co-seismic jumps while estimating velocities, ignore periods of post-seismic deformation, and exclude time-series that reflect magmatic and anthropogenic activity. GPS velocities were used to estimate angular velocities for 36 of the 50 rigid plates and blocks (the rest being taken from the literature), and these were used as boundary conditions in the strain rate calculations. For the strain rate calculations we used the method of Haines and Holt. In order to fit the data equally well

An integrated, cross-disciplinary study of soil hydrophobicity at atomic, molecular, core and landscape scales

NASA Astrophysics Data System (ADS)

Matthews, G. Peter; Doerr, Stefan; Van Keulen, Geertje; Dudley, Ed; Francis, Lewis; Whalley, Richard; Gazze, Andrea; Hallin, Ingrid; Quinn, Gerry; Sinclair, Kat; Ashton, Rhys

2017-04-01

by ESI and MALDI TOF mass spectrometry and database searches, (ii) the examination of such proteins, which form ordered hydrophobic ridges, and measurement of their elasticity, stickiness and hydrophobicity at nano- to microscale using atomic force microscopy adapted for the rough surfaces of soil particles, (iii) the novel use of a picoliter goniometer to show hydrophobic effects at a 1 micron diameter droplet level, which avoids the averaging over soil cores and particles evident in microliter goniometry, with which the results are compared, (iv) measurements at core scale using water retention and wicking experiments, and (v) the modelling and upscaling of the results from molecular to core scale using the PoreXpert void network model of dynamic wetting and Haines jumps. An explanation will also be given as to how the results will be further upscaled by incorporation into the JULES hydrological model of the UK Meteorological Office, used to predict flooding for different soil types and usage.

Instantaneous deformation and kinematics of the India-Australia Plate

NASA Astrophysics Data System (ADS)

Delescluse, Matthias; Chamot-Rooke, Nicolas

2007-02-01

Active intraplate deformation of the India-Australia Plate is now being captured by far-field global positioning system (GPS) measurements as well as measurements on a few islands located within the deforming zone itself. In this paper, we combine global and regional geodetic solutions with focal mechanisms of earthquakes to derive the present-day strain field of the India-Australia Plate. We first compile an updated catalogue of 131 Indian intraplate earthquakes (M > 5) spanning the period between the two Asian mega earthquakes of Assam 1897 and Sumatra 2004. Using Haines and Holt's numerical approach applied to a fully deformable India-Australia Plate, we show that the use of GPS data only or earthquakes data only has severe drawbacks, related, respectively, to the small number of stations and the incompleteness of the earthquakes catalogue. The combined solution avoids underestimation of the strain inherent to the Kostrov summation of seismic moments and provides details that cannot be reached by pure GPS modelling. We further explore the role of heterogeneity of the India-Australia Plate and find that the best model, in terms of geodetic vectors fit, relative distribution of strain, style and direction of principal strain from earthquakes, is obtained using the surface heat-flow as a proxy for rheological weakness of the oceanic lithosphere. The present-day deformation is distributed around the Afanasy Nikitin Chain in the Central Indian Basin (CIB)-where it is almost pure shortening-and within the Wharton Basin (WB) off Sumatra-where it is almost pure lateral strike-slip. The northern portion of NinetyEast ridge (NyR) appears as a major discontinuity for both strain and velocity. The new velocity field gives an India/Australia rotation pole located at 11.3°S, 72.8°E (-0.301°Myr-1) overlapping with previous solutions, with continental India moving eastward at rates ranging from 13 mm yr-1 (southern India) to 26 mm yr-1 (northern India) with respect to

Correlation of Specific Mutations in Line Probe Assay (LPA) and Drug Susceptibility Test (DST) with respect to Fluoroquinolone Resistance in Drug Resistant Mycobacterium tuberculosis

PubMed Central

Agrawal, Umang; Savaj, Pratik; Davda, Kanishka; Rodrigues, Camilla; Soman, Rajeev

2017-01-01

Abstract Background This study was done to investigate the utility of specific fluoroquinolone mutations in LPA in predicting the susceptibility in DST at WHO recommended Critical Concentrations of 0.5 and 2 µg/dL of moxifloxacin within a short time frame as provided by LPA. Methods In a retrospective study performed at a tertiary care hospital of Mumbai, India from October 2015 to February 2017, consecutive samples demonstrating fluoroquinolone resistance by LPA were selected. The LPA kit used was Hain Lifescience Genotype MTBDRsl (Version 1). It detects the following mutations in gyrA gene: MUT1: Ala90Val, MUT2: Ser91Pro, MUT3A: Asp94Ala, MUT3B: Asp94Asn/Tyr, MUT3C: Asp94Gly, MUT3D: Asp94His. The causal mutation was noted. For 89 of these samples, DST had been requested and results with Critical Concentration of 0.5µg/dL and 2µg/dL for moxifloxacin were available Results The 89 samples studied were as follows: Sputum (n = 60), paravertebral soft tissue (n = 2), bronchoalveolar fluid (n = 2), cerebrospinal fluid (n = 1), endotracheal tube secretion (n = 1), pleural fluid (n = 1) and site not recorded (22). 3 of these samples had double mutations. Results are as follows. Mutation in gyrA gene Number of samples (n) Susceptible at 0.5 µg/dL [n (%)] Susceptible at 2 µg/dL [n (%)] MUT1 (Ala90Val) 18 6(33.33) 16(88.89) MUT2 (Ser91Pro) 2 0(0) 1(50) MUT3A (Asp94Asn) 13 3(23.07) 11(84.61) MUT3B (Asp94Asn/Tyr) 6 1(16.67) 4(66.67) MUT3C (Asp94Gly) 51 4(8) 43(84.31) MUT3D (Asp94His) 2 0(0) 2(100) Conclusion This study showed a higher proportion of M. tuberculosis susceptibility at 2 µg/dL rather than at 0.5 µg/dL, to moxifloxacin for gyrA mutations Ala90Val (MUT1), Asp94Ala (MUT3A), Asp94Gly (MUT3C), Asp94His (MUT3D) but not for Ser91Pro (MUT2) and Asp94Asn/Tyr (MUT3B). However, the number of samples with Ser91Pro (MUT2) and Asp94Asn/Tyr (MUT3B) mutations was too small for meaningful conclusion. This susceptibility at a higher critical concentration of

A New Global Geodetic Strain Rate Model

NASA Astrophysics Data System (ADS)

Kreemer, C. W.; Klein, E. C.; Blewitt, G.; Shen, Z.; Wang, M.; Chamot-Rooke, N. R.; Rabaute, A.

2012-12-01

conditions for the strain rate calculations. For the strain rate calculations we used the method of Haines and Holt. In order to equally fit the data in slowly and rapidly deforming areas, we first calculated a very smooth model by setting the a priori variances of the strain rate components very low. We then used this model as a proxy for the a priori standard deviations of the final model. To add some more constraints to the model (to make it more stable), we manipulated the a priori covariance matrix to reflect the expected style of deformation derived from (an interpolation of) shallow earthquake focal mechanisms. We will show examples of the strain rate and velocity field results. We will also highlight how and where the results can be viewed and accessed through a dedicated webportal.

Surface vitrification caused by natural fires in Late Pleistocene wetlands of the Atacama Desert

NASA Astrophysics Data System (ADS)

Roperch, Pierrick; Gattacceca, Jerome; Valenzuela, Millarca; Devouard, Bertrand; Lorand, Jean-Pierre; Arriagada, Cesar; Rochette, Pierre; Latorre, Claudio

2017-04-01

cases of silicate glasses attributed to airbursts, challenging the high airburst rate as well as the interpretation of fossils and organic matter in "impact glasses" [5]. Our study also demonstrates that exotic mineralogy with glass containing spherules of iron sulphides, metallic iron or iron phosphides may not necessarily imply an impact origin. This in turn cast doubts on some studies relating impact and climate change triggering the Younger Dryas cold event at the end of the Pleistocene [6]. 1. French, B. M. & Koeberl, C. Earth-Sci. Rev. 98, 123-170 (2010). 2. Osinski, G. R. et al. Meteorit. Planet. Sci. 43, 2089-2107 (2008). 3. Haines, P. W., Jenkins, R. J. F. & Kelley, S. P. Geology 29, 899 (2001). 4. Blanco, N. & Tomlinsson, A. J. Carta Guatacondo, Región de Tarapacá. (2013). 5. Schultz, P. H., Harris, R. S., Clemett, S. J., Thomas-Keprta, K. L. & Zarate, M. Geology 42, 515-518 (2014). 6. Firestone, R. B. et al. Proc. Natl. Acad. Sci. 104, 16016-16021 (2007).

Satellite surface salinity maps to determine fresh water fluxes in the Arctic Ocean

NASA Astrophysics Data System (ADS)

Gabarro, Carolina; Estrella, Olmedo; Emelianov, Mikhail; Ballabrera, Joaquim; Turiel, Antonio

2017-04-01

, results make you think that assimilating SMOS Arctic SSS data could be beneficial for the TOPAZ Arctic Ocean Prediction system. Therefore, SMOS shows great potential to routinely monitor the extension of the surface freshwater fluxes also in the Arctic Ocean. The new SMOS Arctic products can therefore substantially contribute to increase our knowledge of the critical processes that are taking place in the Arctic. [1] Haine, T. et al. (2015), 'Arctic freshwater export: Status, mechanisms, and prospects', Global and Planetary Change, 125, 2015. [2] Peterson, B., et al. (2002), 'Increasing river discharge to the arctic ocean', Science, 298, 21712173. [3] Font, J. et al. (2010), 'The Challenging Sea Surface Salinity Measurement From Space'. Proceed. IEEE, 98, 649 -665 [4] Swift, C. (1980). Boundary-layer Meteorology, 18:25-54. [5] McMullan, K. et al. (2008), 'SMOS: The payload', IEEE T. Geosci. Remote, 46. [6] Olmedo, E., et al. (2017) 'Debiased Non-Bayesian retrieval: a novel approach to SMOS Sea Surface Salinity', Remote Sensing of Environment, under review.

PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

NASA Astrophysics Data System (ADS)

Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

2010-04-01

. The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

PREFACE: Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer Celebrating 20 years of Journal of Physics: Condensed Matter—in honour of Richard Palmer

NASA Astrophysics Data System (ADS)

Ferry, David; Dowben, Peter; Inglesfield, John

2009-11-01

This year marks the 20th anniversary of the launch of Journal of Physics: Condensed Matter in 1989. The journal was formed from the merger of Journal of Physics C: Solid State Physics and Journal of Physics F: Metal Physics which had separated in 1971. In the 20 years since its launch, Journal of Physics: Condensed Matter has more than doubled in size, while raising standards. Indeed, Journal of Physics: Condensed Matter has become one of the leading scientific journals for our field. This could not have occurred without great leadership at the top. No one has been more responsible for this growth in both size and quality than our Senior Publisher, Richard Palmer. Richard first started work at IOP in March 1971 as an Editorial Assistant with J. Phys. B After a few months, he transferred to J. Phys.C The following year, the Assistant Editor of J. Phys. C, Malcolm Haines, left suddenly in order to work on his family vineyard in France, and Richard stepped into the breach. In those days, external editors had a much more hands-on role in IOP Publishing and he had to travel to Harwell to be interviewed by Alan Lidiard, the Honorary Editor of J. Phys. C, before being given the job of Assistant Editor permanently. Since J. Phys. C and J. Phys. F re-merged to form Journal of Physics: Condensed Matter, Richard gradually shed his other journal responsibilities, except for Reports on Progress in Physics, to build up Journal of Physics: Condensed Matter. He has worked closely with four Editors-in-Chief of J. Phys. C and five of Journal of Physics: Condensed Matter. When Richard announced his retirement this past winter, we met it with a great deal of both happiness and sadness. Of course, we are happy that he is going to be allowed to enjoy his retirement, but we remain very sad to lose such a valuable member of our team, especially the one who had provided the heart and soul of the journal over its 20 years. We will be able to rely upon the team which Richard ably trained as

Developing a high-resolution regional atmospheric reanalysis for Australia

NASA Astrophysics Data System (ADS)

White, Christopher; Fox-Hughes, Paul; Su, Chun-Hsu; Jakob, Dörte; Kociuba, Greg; Eisenberg, Nathan; Steinle, Peter; Harris, Rebecca; Corney, Stuart; Love, Peter; Remenyi, Tomas; Chladil, Mark; Bally, John; Bindoff, Nathan

2017-04-01

, precipitation, evaporation, soil water, and energy fluxes. In this presentation, we report on the implementation of the Australia regional reanalysis and results from first stages of the project, with a focus on the Tasmanian subdomain. An initial benchmarking 1.5 km data set - referred to as the 'Initial Analysis' - has been constructed over the subdomains consisting of regridded and harmonised analysis and short-term forecast fields from the operational ACCESS-C model using the past 5 years (2011-2015) of archived data. Evaluation of the Initial Analysis against surface observations from automatic weather stations indicate changes in model skills over time that may be attributed to changes in NWP and assimilation systems, and model cycling frequency. Preliminary evaluations of the reanalysis across Tasmania and its inter-comparisons with the Initial Analysis and the ERA-Interim reanalysis products will be presented, including some features across the Tasmanian subdomain such as means and extremes of analysed weather variables. Finally, we describe a number of applications across Tasmania of the reanalysis of immediate interest to meteorologists, fire and landscape managers and other members of the emergency management community, including the use of the data to create post-processed fields such as soil dryness, tornados and fire danger indices for forest fire danger risk assessment, including a climatology of Continuous Haines Index.

PBS Plus Facebook: The Old And New Communication Of Climate Science (Please "Like" And "Share" This Abstract)

NASA Astrophysics Data System (ADS)

Alley, R. B.; Haines-Stiles, G.; Akuginow, E.

2012-12-01

Traditional and innovative communications strategies were combined in "Earth: The Operators' Manual" (ETOM; writer & director Geoff Haines-Stiles, producer Erna Akuginow, presenter Richard Alley). We attempted both a clear and accessible presentation of some key essentials of current climate science and an experiment in new messaging and new media for outreach and education. ETOM is a 3-part TV series broadcast by PBS ("…one of the more interesting documentary series to come along in years", said the New York Times) and a 320 plus page tradebook, with 110 pages of footnotes referencing peer-reviewed science, published by Norton. But it's also a lively and growing Facebook page with a clear voice sharing positive examples of how renewable energy can reduce polluting emissions here in the US and worldwide, alongside headlines of climate science, and a website—relaunched for the 2012 Earth Day PBS broadcasts—where all three programs can be streamed, and teachers can register to download HD segments for classroom use. The TV programs were designed to offer a highly accessible statement of core climate science, literally explaining how ice cores show us today's climate is changing in ways not seen in the last 800,000 thousand years and why physics and chemistry let us know "It's Us" who are changing CO2 levels in the atmosphere through burning fossil fuels. But the project's outreach components also includes a "Science Pub" in a converted theater in Portland, where the audience consumes food, drink and climate science, and "Adventures of a Climate Scientist in the Age of Politics and Punditry," a dynamic live performance recorded for TV and the web. Messaging includes a Navy Rear Admiral in dress whites explaining why the Pentagon believes climate change is real, and scenes showing Marines and Army implementing solar technologies to enhance mission security and reduce their carbon bootprint. Similarly, outreach events at the North Carolina Museum of Natural

Research Enabled through Eighteen Years of Geodesy Data Sharing by the UNAVCO Data Center

NASA Astrophysics Data System (ADS)

Boler, F. M.; Meertens, C. M.; Kreemer, C. W.; Blewitt, G.

2009-12-01

et al., 2003]. An important contribution to these analyses for the Great Basin is MAGNET, a 307-station array operated by the University of Nevada with 30-50 active stations per day since 2004 [Blewitt et al., 2004]. The simultaneous increase in GNSS data and analysis expertise now allows for routine global analysis of many thousands of GNSS stations. Such analysis ensures that all phase ambiguities are fixed and that common-mode errors are significantly reduced and thereby allow for increased spatial and temporal resolution for strain-rate models and other solid-earth investigations. These examples highlight two research areas where exciting advances are built upon the GNSS data available from the UNAVCO Data Center. The continued open availability of GNSS data will provide an invaluable resource for refinement of current understanding of geodesy and completely new discoveries into the future. Blewitt, G., C. Kreemer, and W.C. Hammond (2009). Geodetic observation of contemporary deformation in the northern Walker Lane: 1. Semipermanent GPS strategy, p. 1-15, doi: 10.1130/2009.2447(03). Kreemer, C., W.E. Holt, and A.J. Haines, An integrated global model of present-day plate motions and plate boundary deformation, Geophys. J. Int., 154, 8-34, 2003.

Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.

PubMed

Meaza, Abyot; Kebede, Abebaw; Yaregal, Zelalem; Dagne, Zekarias; Moga, Shewki; Yenew, Bazezew; Diriba, Getu; Molalign, Helina; Tadesse, Mengistu; Adisse, Desalegn; Getahun, Muluwork; Desta, Kassu

2017-04-17

Multi drug resistant tuberculosis (MDR-TB) poses formidable challenges to TB control due to its complex diagnostic and treatment challenges and often associated with a high rate of mortality. Accurate and rapid detection of MDR-TB is critical for timely initiation of treatment. Line Probe Assay (LPA) is a qualitative in vitro diagnostic test based on DNA-STRIP technology for the identification of the M. tuberculosis complex and its resistance to rifampicin (RMP) and/or isoniazid (INH). Hain Lifescience, GmbH, Germany has improved the sensitivity of Genotype MTBDRplus VER 2.0 LPA for the detection of MDR-TB; with the possibility of applying the tool in smear negative sputum samples. A cross sectional study was conducted on 274 presumptive MDR-TB patients referred to the National TB Reference Laboratory (NTRL), Ethiopian Public Health Institute (EPHI) who submitted sputum samples for laboratory diagnosis of drug resistant-TB testing. Seventy-two smear and culture positive samples processed in smear positive direct LPA category and 197 smear negative sputum samples were processed for direct LPA. Among the smear negative samples 145 (73.6%) were culture negative and 26 (13.2%) were culture positive. All specimens were processed using NALC-NaOH method and ZN smear microscopy done from sediments. Genotype MTBDRplus VER 2.0 done from processed sputum sediments and the result was compared against the reference, BACTEC MGIT 960 culture and DST. Sensitivity, specificity, PPV and NPV of Genotype MTBDRplus VER 2.0 assay was determined and P-value <0.05 was considered as statistically significant. The sensitivity, specificity, PPV and NPV of Genotype MTBDRplus VER 2.0 LPA were 96.4, 100, 100 and 96.9%, respectively for the detection of MDR-TB from direct smear positive sputum samples. The sensitivity, specificity, PPV and NPV of Genotype MTBDR plus VER 2.0 LPA were 77.8, 97.2, 82.4 and 97.2%, respectively, for the detection of M. tuberculosis from direct smear negative sputum

IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

PubMed Central

Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar

2015-01-01

, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, ‘t Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Seniori Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123:507–514; http://dx.doi.org/10.1289/ehp.1409149 PMID:25712798

Micro-Ct Imaging of Multi-Phase Flow in Carbonates and Sandstones

NASA Astrophysics Data System (ADS)

Andrew, M. G.; Bijeljic, B.; Blunt, M. J.

2013-12-01

grain, brine and CO2. Experiments were repeated five times for each rock type, allowing for statistical errors to be estimated. The images from each experiment were approximately 900x900x3200 voxels, representing a sample size of approximately 6.4mm x 6.4mm x 22.4mm. Higher residual saturations were found in the sandstones (Bentheimer: 0.299×0.009, Doddington: 0.27×0.03) than in the carbonates (Mt Gambier: 0.187×0.007, Estaillades: 0.190×0.005, Ketton: 0.193×0.012). The size frequency distribution of ganglia was also examined. The largest ganglia contributed negligibly to the total residual saturation in all cases apart from Mt Gambier, where the increased connectivity of the pore-space inhibits non-wetting phase snap-off. The snap-off of ganglia is understood theoretically as a percolation process, and ganglia size distributions show approximately power-law distributions with exponents agreeing with predictions from percolation theory apart from in Mt Gambier limestone, where the extreme connectivity of the pore space may cause snap-off to be a non-percolation like process. We also present the first dynamic real time multiphase fluid displacements at reservoir conditions. These images were taken using the same reservoir-condition flow rig at Diamond Light Source synchrotron. This advanced facility allows for scanning intervals of 30 seconds, enabling the imaging of discrete pore-filling events (Haines jumps).

Pulmonary Rehabilitation With Balance Training for Fall Reduction in Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Trial.

PubMed

Beauchamp, Marla K; Brooks, Dina; Ellerton, Cindy; Lee, Annemarie; Alison, Jennifer; Camp, Pat G; Dechman, Gail; Haines, Kimberley; Harrison, Samantha L; Holland, Anne E; Marques, Alda; Moineddin, Rahim; Skinner, Elizabeth H; Spencer, Lissa; Stickland, Michael K; Xie, Feng; Goldstein, Roger S

2017-11-20

be returned to the research centers in prepaid envelopes each month. Secondary measures collected by a blinded assessor at baseline (pre-PR), post-PR, and 12-month follow-up will include clinical measures of balance, balance confidence, functional lower body strength, and health status. The cost-effectiveness of the intervention group compared with the control group will be evaluated using the incremental cost per number of falls averted and the incremental cost per quality-adjusted life years gained. Recruitment for the study began in January 2017 and is anticipated to be complete by December 2019. Results are expected to be available in 2020. Findings from this study will improve our understanding of the effectiveness and resource uses of tailored balance training for reducing falls in individuals with COPD. If effective, the intervention represents an opportunity to inform international guidelines and health policy for PR in individuals with COPD who are at risk of falling. ClinicalTrials.gov NCT02995681; https://clinicaltrials.gov/ct2/show/NCT02995681 (Archived by WebCite at http://www.webcitation.org/6ukhxgAsg). ©Marla K Beauchamp, Dina Brooks, Cindy Ellerton, Annemarie Lee, Jennifer Alison, Pat G Camp, Gail Dechman, Kimberley Haines, Samantha L Harrison, Anne E Holland, Alda Marques, Rahim Moineddin, Elizabeth H Skinner, Lissa Spencer, Michael K Stickland, Feng Xie, Roger S Goldstein. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 20.11.2017.

Mid Pliocene sea levels along the southeast US coastal plain

NASA Astrophysics Data System (ADS)

Rovere, A.; Hearty, P. J.; Raymo, M. E.; Mitrovica, J. X.; Inglis, J.

2012-12-01

South Carolina, the Orangeburg Scarp can be regarded as the shoreline of the Duplin formation. Southwards, in Georgia and north Florida, the Trail Ridge is associated with the Wicomico Formation, and continues in South Florida with the Haines City Ridge. All these morphological features, associated with formations composed by marine shells and gravels, have been attributed Plio-Pleistocene ages. Though their geological characteristics have been described in detail by several authors (e.g. Winker and Howard, Geology, 1977), their elevation, age and lateral continuity have been poorly constrained. Using LIDAR data and Digital Elevation Models from different state and federal sources we defined the main geomorphological features of MPWP shorelines from Virginia to Florida. Combining the information obtained by literature, elevation datasets, and aerial imagery we identified sites where field surveys have been carried out. During the field surveys, both the elevation and geomorphological features associated to sea level have been mapped and sampled. This combination of GIS methods and field techniques allowed us to map the extent, constrain the elevation, and correlate marine deposits related to MPWP shorelines along the east coast of the US. We will discuss these results, as well as the new insights they provide on glacial isostasy, dynamic topography and tectonic processes occurring within this region.

Similarities between several major extinctions and preservation of life - biomolecules to geomolecules: an interdisciplinary approach

NASA Astrophysics Data System (ADS)

Grice, Kliti; Melendez, Ines; Tulipani, Svenja

2015-04-01

coexistence of biomolecules and geomolecules in the same sample, previously assumed unfeasible. The coexistence of steroids in a diagenetic continuum, ranging from stenols to triaromatic steroids, is attributed to microbially mediated eogenetic processes. Under exceptional conditions concretions preserve biomolecules at extraordinary levels, providing a new opportunity to study the distributions of biomolecules in deep time and thereby improving our understanding of the evolution of life where fossils are rarely preserved. References [1] Grice K., Cao C., Love G.D., Bottcher M.E., Twitchett R,, Grosjean E., Summons R.E., Turgeon S., Dunning W.J. & Jin Y., 2005. Photic zone euxinia during the Permian-Triassic superanoxic event. Science. 307, 706-709. [2] Jaraula C.M.B, Grice K., Twitchett R.,J., Böttcher M.E., Le Metayer P., Dastidar A.G. & Opazo L.F., 2013. Elevated pCO2 leading to Late triassic extinction, persistent photic zone euxinia, and rising sea levels. Geology 41, 955-958. [3] Tulipani S., Grice K., Greenwood P.F, Haines P., Sauer P., Schimmelmann A., Summons R.E., Foster C.B., Böttcher M.E., Playton, T. & Schwark L., 2014a. Changes in palaeoenvironmental conditions in Late Devonian Reef systems from the Canning Basin, WA: A biomarker and stable isotope approach. Gondwana Research, in press. [4] Melendez I., Grice K., Trinajstic K., Ladjavardi M., Thompson K. & Greenwood P.F., 2013a. Biomarkers reveal the role of photic zone euxinia in exceptional fossil preservation: An organic geochemical perspective. Geology 41, 123-126. [5] Melendez I., Grice K. & Schwark L., 2013b. Exceptional preservation of palaeozoic steroids in a diagenetic continuum. Nature Scientific Reports. 3. [6] Grice K., Lu H., Atahan P., Hallmann, C., Asif M., Greenwood P.F., Tulipani S., Maslen E., Williford W.H. & Dodson J. 2009. New insights into the origin of perlyene in geological samples Geochimica et Cosmochimica Acta, 73, 6531-6543. [7] Tulipani S., Grice K., Greenwood P.F., Schwark L

Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis.

PubMed

Drobniewski, Francis; Cooke, Mary; Jordan, Jake; Casali, Nicola; Mugwagwa, Tendai; Broda, Agnieszka; Townsend, Catherine; Sivaramakrishnan, Anand; Green, Nathan; Jit, Mark; Lipman, Marc; Lord, Joanne; White, Peter J; Abubakar, Ibrahim

2015-05-01

introducing rapid molecular testing (in addition to culture and drug sensitivity testing). Probabilistic sensitivity analysis was performed to evaluate the impact on cost-effectiveness of diagnostic and treatment time delays, diagnosis and treatment costs, and associated QALYs. A total of 8922 titles and abstracts were identified, with 557 papers being potentially eligible. Of these, 56 studies contained sufficient test information for analysis. All three commercial tests performed well when detecting drug resistance in clinical samples, although with evidence of heterogeneity between studies. Pooled sensitivity for GenoType® MTBDRplus (Hain Lifescience, Nehren, Germany) (isoniazid and rifampicin resistance), INNO-LiPA Rif.TB® (Fujirebio Europe, Ghent, Belgium) (rifampicin resistance) and Xpert® MTB/RIF (Cepheid Inc., Sunnyvale, CA, USA) (rifampicin resistance) was 83.4%, 94.6%, 95.4% and 96.8%, respectively; equivalent pooled specificity was 99.6%, 98.2%, 99.7% and 98.4%, respectively. Results of the transmission model suggest that all of the rapid assays considered here, if added to the current diagnostic pathway, would be cost-saving and achieve a reduction in expected QALY loss compared with current practice. GenoType MTBDRplus appeared to be the most cost-effective of the rapid tests in the South Asian population, although results were similar for GeneXpert. In all other scenarios GeneXpert appeared to be the most cost-effective strategy. Rapid molecular tests for rifampicin and isoniazid resistance were sensitive and specific. They may also be cost-effective when added to culture drug susceptibility testing in the UK. There is global interest in point-of-care testing and further work is needed to review the performance of emerging tests and the wider health-economic impact of decentralised testing in clinics and primary care, as well as non-health-care settings, such as shelters and prisons. This study is registered as PROSPERO CRD42011001537. The National Institute

EDITORIAL: Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter

NASA Astrophysics Data System (ADS)

Ferry, David

2009-01-01

It is with a great deal of both happiness and sadness that I have to announce that we are losing one of the real strengths of the Journal of Physics: Condensed Matter (JPCM). Dr Richard Palmer, our Senior Publisher, announced his retirement, and this issue marks the first without his involvement. Of course, we are happy that he will get to enjoy his retirement, but we are sad to lose such a valuable member of our team. Richard first started work at IOP Publishing in March 1971 as an Editorial Assistant with Journal of Physics B: Atomic and Molecular Physics. After a few months, he transferred to Journal of Physics C: Solid State Physics. During his first year, he was sent on a residential publishing training course and asked to sign an undertaking to stay at IOP Publishing for at least two years. Although Richard refused to sign, as he did not want to commit himself, he has remained with the journal since then. The following year, the Assistant Editor of Journal of Physics C: Solid State Physics, Malcolm Haines, walked out without notice in order to work on his family vineyard in France, and Richard stepped into the breach. In those days, external editors had a much more hands-on role in IOP Publishing and he had to travel to Harwell to be interviewed by Alan Lidiard, the Honorary Editor of Journal of Physics C: Solid State Physics, before being given the job of Assistant Editor permanently. I am told that in those days the job consisted mainly of editing and proofreading and peer review. There was no journal development work. At some point in the early 1980s, production and peer review were split into separate departments and Richard then headed a group of journals consisting of Journal of Physics C: Solid State Physics, Journal of Physics D: Applied Physics and Journal of Physics F: Metal Physics, Semiconductor Science and Technology, Superconductor Science and Technology, Plasma Physics and Controlled Fusion, and later Nanotechnology and Modelling and Simulation

The Second Great Thermal Event from the History of the Solar System as Origin of the Lunar Asymmetries and Paleomagnetism

NASA Astrophysics Data System (ADS)

Neagu, A.

1993-07-01

answer of the lunar interior and its asymmetric structure permitted mare volcanism to occur only on the nearside [10]. This model is strongly supported by isotopic, petrologic, and magnetic analyses of lunar nearside rocks that give abundant evidence for a widespread thermal metamorphism at about 3.9 Ga. It is reflected especially in partial to complete equilibration of the isotopic systems [8], in the redistribution of volatiles on lunar surface [11-13] and in the thermoremanent magnetization of lunar breccias [14]. This model also explains the asymmetric distribution of the thorium concentrations in the lunar surface [15] and the presence, near the lunar surface, of rocks of deep-seated origin [16]. References: [1] Nagata T. et al. (1970) Proc. Apollo 11 LSC, 2325. [2] Strangway D. W. (1971) EPSL, 13, 43. [3] Kaula W. M. et al. (1972) Proc. LSC 3rd, 2189. [4] Kaula W. M. et al. (1974) Proc. LSC 5th, 3049. [5] Haines E. L. and Metzger A. E. (1980) Proc. LPSC 11th, 689. [6] Stevenson D. J. (1980) Nature, 287, 520. [7] Ransford G. and Sjogren W. (1972) Nature, 238, 260. [8] Wasserburg G. J. et al. (1977) Phil. Trans. R. Soc. Lond., A285, 7. [9] Neagu A. (1993) 18th EGS Meeting, Wiesbaden. [10] Neagu A. (1992) Meteoritics, 27, 267. [11] Tera F. and Wasserburg G. J. (1972) EPSL, 14, 281. [12] Nunes P. D. and Tatsumoto M. (1973) Science, 182, 916. [13] Cirlin E. H. and Housley R. M. (1980) Proc. LPSC 11th, 349. [14] Gose W. A. et al. (1978) EPSL, 38, 373. [15] Metzger A. E. et al. (1977) Proc. LSC 8th, 949. [16] James O. B. (1980) Proc. LPSC 11th, 365. Fig. 1, which appears here in the hard copy, shows a schematic equatorial cross section of the Moon showing the lunar internal structure before and after SGTE occurred. Fig. 2 appears here in the hard copy.

Pharmacological interventions for pain in children and adolescents with life-limiting conditions.

PubMed

Beecham, Emma; Candy, Bridget; Howard, Richard; McCulloch, Renée; Laddie, Jo; Rees, Henrietta; Vickerstaff, Victoria; Bluebond-Langner, Myra; Jones, Louise

2015-03-13

Pain is one of the most common symptoms in children and young people (CYP) with life-limiting conditions (LLCs) which include a wide range of diagnoses including cancer. The current literature indicates that pain is not well managed, however the evidence base to guide clinicians is limited. There is a clear need for evidence from a systematic review to inform prescribing. To evaluate the evidence on the effectiveness of different pharmacological interventions used for pain in CYP with LLCs. The following electronic databases were searched up to December 2014: CENTRAL (in the Cochrane Library), MEDLINE, EMBASE, PsycINFO and CINAHL. In addition, we searched conference proceedings and reference lists of included studies. For completeness, we also contacted experts in the field. No language restrictions were applied. Randomised controlled trials (RCTs), quasi-randomised studies and other studies that included a clearly defined comparator group were included. The studies investigated pharmacological treatments for pain associated with LLCs in CYP. The treatment included those specifically developed to treat pain and those that acted as an adjuvant, where the treatment was not primarily developed to treat pain but has pain relieving properties. The LLC was identified by its inclusion in the Richard Hain Directory of LLCs. Citations were screened by five review authors. Data were extracted by one review author and checked by a second. Two review authors assessed the risk of bias of included studies. A sufficient number of studies using homogeneous outcomes was not identified so a meta-analysis was not possible. We identified 24,704 citations from our database search. Nine trials with 379 participants fulfilled our inclusion criteria. Participants had cerebral palsy (CP) in five of the studies and osteogenesis imperfecta (OI) in the other four. Participants across the trials ranged in age from 2 to 19 years. All studies, apart from one cross-over trial, were parallel

PREFACE: The first 21 years of reverse Monte Carlo modelling—a workshop held in Budapest, Hungary (1-3 October 2009) The first 21 years of reverse Monte Carlo modelling—a workshop held in Budapest, Hungary (1-3 October 2009)

NASA Astrophysics Data System (ADS)

Keen, David A.; Pusztai, László

2010-10-01

scientific community by showing the current state-of-the-art research opportunities using the RMC method. Furthermore, by including a small number of papers from colleagues working on similar disordered problems with complementary analysis techniques, we hope that the RMC method may be placed in a broader scientific context. The papers have been arranged in order of increasing structural disorder, starting with studies of crystalline systems, through to amorphous materials and liquids, and ending with RMC developments using small-angle scattering. We are very grateful to IOP Publishing for their willingness to publish this collection of papers which celebrates the 21st anniversary of the first RMC publication in a special issue of Journal of Physics: Condensed Matter and for their co-ordination of the refereeing process. References [1] McGreevy R L 2001 J. Phys.: Condens. Matter 13 R877 [2] Keen D A and Pusztai L (ed) 2007 Proc. of RMC-3 (Budapest, Sept. 2006) J. Phys.: Condens. Matter 19 330301-335223 [3] Keen D A, Pusztai L and Dove M T (ed) 2005 Proc. of RMC-2 (Budapest, Oct. 2003) J. Phys.: Condens. Matter 17 S1-S174 [4] Nguyen T X, Cohaut N, Bae J-S and Bhatia S K 2008 Langmuir 24 7912 [5] Zhang H, Chen B and Banfield J F 2008 Phys. Rev. B 78 214106 [6] Goodwin A L, Calleja M, Conterio M J, Dove M T, Evans J S O, Keen D A, Peters L and Tucker M G 2008 Science 319 794 [7] Norberg S T, Tucker M G and Hull S 2009 J. Appl. Cryst. 42 179 [8] See www.RMCProfile.org, www.RMC-forum.org or www.szfki.hu/~nphys/rmc++/opening.html [9] Haines J, Levelut C, Isambert A, Hébert P, Kohara S, Keen D A, Hammouda T and Andrault D 2009 J. Am. Chem. Soc. 131 12333

PREFACE: International Conference on Strongly Correlated Electron Systems (SCES 2011)

NASA Astrophysics Data System (ADS)

Littlewood, P. B.; Lonzarich, G. G.; Saxena, S. S.; Sutherland, M. L.; Sebastian, S. E.; Artacho, E.; Grosche, F. M.; Hadzibabic, Z.

2012-11-01

, Kyushu G. R. Stewart, Gainesville C. Di Castro, Rome R. Osborn, Chicago H. Takagi, Tokyo M. Eremets, Mainz S. Ovchnikov, Krasnoyarsk L. Taillefer, Sherbrooke M. Fiebig, Bonn C. Panagopoulos, Singapore & Heraklion J. D. Thompson, Los Alamos Z. FiskIrvine S. Paschen, Vienna Y. Tokura, Tokyo J. Flouquet, Grenoble C. Pfleiderer, Munich K. Ueda, Tokyo P. Fulde, Dresden P. Phillips, Urbana C. M. Varma, Riverside A. Geim, Manchester D. Pines, Davis T. Vojta, Rolla J.C. Gomez-Sal, Santander T. V. Ramakrishnan, Bangalore N.L. Wang, Beijing A. Kavokin, Southampton A.K. Raychaudhuri, Calcutta T. Xiang, Beijing J. Goodenough, Austin M. Reifers, Kosice L. Yu, Beijing H. Hosono, Tokyo P. Riseborough, Philadelphia F. C. Zhang, Hong Kong S. Julian, Toronto M. L Saboungi, Orleans G. Zwicknagl, Braunschweig Operational Team Anson Cheung (co-ordinator)Hyeong Jin KimPaul Nahai-Williamson Beng Tan (co-ordinator)Jack GillettPeter Logg Cheng Liu (co-ordinator)Jo WensleyPrajakti Kalra Swee K. Goh (co-ordinator)Jonathan SilverRichard Brierley Adam HalskiLara SibleyRobert Hay Edd CavannaLeona HopeSeb Haines Felix NissenLina KlintbergSitikantha Das Gareth ConduitMarianne BauerStephen Rowley Gerie LonzarichMatt BurgessSven Friedemann Greg LeverMuhammad Ahsan ZebYang Zou Hannah PriceNick BristoweYiqian Xu Haruka TaniguchiOleksandr PoplavskyyZhuo Feng