Sample records for haling power depletion

  1. Understanding the haling power depletion (HPD) method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levine, S.; Blyth, T.; Ivanov, K.

    2012-07-01

    The Pennsylvania State Univ. (PSU) is using the university version of the Studsvik Scandpower Code System (CMS) for research and education purposes. Preparations have been made to incorporate the CMS into the PSU Nuclear Engineering graduate class 'Nuclear Fuel Management' course. The information presented in this paper was developed during the preparation of the material for the course. The Haling Power Depletion (HPD) was presented in the course for the first time. The HPD method has been criticized as not valid by many in the field even though it has been successfully applied at PSU for the past 20 years.more » It was noticed that the radial power distribution (RPD) for low leakage cores during depletion remained similar to that of the HPD during most of the cycle. Thus, the Haling Power Depletion (HPD) may be used conveniently mainly for low leakage cores. Studies were then made to better understand the HPD and the results are presented in this paper. Many different core configurations can be computed quickly with the HPD without using Burnable Poisons (BP) to produce several excellent low leakage core configurations that are viable for power production. Once the HPD core configuration is chosen for further analysis, techniques are available for establishing the BP design to prevent violating any of the safety constraints in such HPD calculated cores. In summary, in this paper it has been shown that the HPD method can be used for guiding the design for the low leakage core. (authors)« less

  2. The Hale Effect

    ERIC Educational Resources Information Center

    Gray, Katti

    2012-01-01

    Ohio State University's (OSU) Frank W. Hale Jr. Black Cultural Center is a rarity in academia, as was its namesake. When OSU named its standout Black cultural center after the civil rights activist, professor and vice provost who championed such a place, it was commemorating what Dr. Frank W. Hale Jr. stood for. He promoted academic rigor, those…

  3. George Ellery Hale, Caltech Astrophysics, and the Hale 200-inch Telescope, 1920-1948

    NASA Astrophysics Data System (ADS)

    Osterbrock, D. E.

    1998-05-01

    Caltech and the 200-inch Hale telescope on Palomar are two of George Ellery Hale's many creations in Southern California. He brought the California Institute of Technology into existence in 1920; Palomar Observatory was built for it. However, even before Hale had "secured" the funds for the 200-inch, astrophysical research had been underway on the Caltech campus in Pasadena, and it intensified after the Rockefeller grant came through. Interactions between the campus, Palomar Mountain, and Mount Wilson Obervatory (one of Hale's earlier creations) played important roles in determining the course of Caltech astrophysics. Changing funding patterns (from private philanthropy to drought, then "defense" weapons-development programs, and then governmental agencies designed to support scientific research) will be briefly described. The 18-inch Schmidt, built at the Caltech (200-inch Telescope) Shop, went into operation in 1936, the first research telescope on Palomar. The 200-inch, essentially completed, was dedicated in 1948 and went into operation for regularly scheduled research observations near the end of 1949. Its coude spectrograph was completed and put into regular use in stages from 1950 to 1952, Among the most important leaders of Caltech astrophysics up to 1948 and the years immediately after it when the 200-inch went into full operation were Robert A. Millikan, Max Mason, and Lee A. DuBridge. Some of the astrophysicists who worked at Caltech and Palomar were Albert Einstein, Richard C. Tolman, Fritz Zwicky, Ira S. Bowen, John A. Anderson, Sinclair Smith, John Strong, William A. Fowler and, just at the end of this period, Jesse L. Greenstein. Some of the key staff personnel were Russell W. Porter, Don O. Hendrix (on loan), and Byron Hill.

  4. LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 AND 1041 (QUARTERS 1 AND J) AT LEFT. VIEW FACING SOUTHWEST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  5. Notes on Species of the Lichen Genus Canoparmelia Elix & Hale in South Korea

    PubMed Central

    Jayalal, Udeni; Joshi, Santosh; Oh, Soon-Ok; Park, Jung-Shin

    2012-01-01

    Detailed descriptions of five species of the lichen genus Canoparmelia Elix & Hale. are presented. Until now, three species of the genus Canoparmelia, including C. apata (Krempelh.) Elix & Hale, C. owariensis (Asah.) Elix, and C. texana (Tuck.) Elix & Hale have been reported in South Korea. Canoparmelia carneopruinata (Zahlbr.) Elix & Hale, C. crozalsiana (de Lesd.) Elix & Hale, and C. ecaperata (Müll. Arg.) Elix & Hale are new to the South Korean lichen flora. An artificial key is provided for all species of Canoparmelia, including the three new records. PMID:23115507

  6. Edward Everett Hale

    NASA Technical Reports Server (NTRS)

    2004-01-01

    The first known proposal for a marned-satellite appeared in a story by Edward Everett Hale entitled The Brick Moon. The story involved a group of young Bostonians who planned to put an artificial satellite into polar orbit for sailors to use to determine longitude accurately and easily.

  7. Comet Hale-Bopp in the constellation Andromeda

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Comet Hale-Bopp was photographed in the constellation Andromeda by George Shelton, photographer for The Bionetics Corp., at 8:14 p.m. on March 31, 1997, from Merritt Island, Florida, close to the Kennedy Space Center. During this 24-hour period, Comet Hale- Bopp is making its closest approach to the Sun.

  8. Vibration and aeroelastic analysis of highly flexible HALE aircraft

    NASA Astrophysics Data System (ADS)

    Chang, Chong-Seok

    The highly flexible HALE (High Altitude Long Endurance) aircraft analysis methodology is of interest because early studies indicated that HALE aircraft might have different vibration and aeroelastic characteristics from those of conventional aircraft. Recently the computer code Nonlinear Aeroelastic Trim And Stability of HALE Aircraft (NATASHA) was developed under NASA sponsorship. NATASHA can predict the flight dynamics and aeroelastic behavior for HALE aircraft with a flying wing configuration. Further analysis improvements for NATASHA were required to extend its capability to the ground vibration test (GVT) environment and to both GVT and aeroelastic behavior of HALE aircraft with other configurations. First, the analysis methodology, based on geometrically exact fully intrinsic beam theory, was extended to treat other aircraft cofigurations. Conventional aircraft with flexible fuselage and tail can now be modeled by treating the aircraft as an assembly of beam elements. NATASHA is now applicable to any aircraft cofiguration that can be modeled this way. The intrinsic beam formulation, which is a fundamental structural modeling approach, is now capable of being applying to a structure consisting of multiple beams by relating the virtual displacements and rotations at points where two or more beam elements are connected to each other. Additional aspects are also considered in the analysis such as auxiliary elevator input in the horizontal tail and fuselage aerodynamics. Second, the modeling approach was extended to treat the GVT environment for HALE aircraft, which have highly flexible wings. GVT has its main purpose to provide modal characteristics for model validation. A bungee formulation was developed by the augmented Lagrangian method and coupled to the intrinsic beam formulation for the GVT modeling. After the coupling procedure, the whole formulation cannot be fully intrinsic because the geometric constraint by bungee cords makes the system statically

  9. Structurally Integrated Antenna Concepts for HALE UAVs

    NASA Technical Reports Server (NTRS)

    Cravey, Robin L.; Vedeler, Erik; Goins, Larry; Young, W. Robert; Lawrence, Roland W.

    2006-01-01

    This technical memorandum describes work done in support of the Multifunctional Structures and Materials Team under the Vehicle Systems Program's ITAS (Integrated Tailored Aero Structures) Project during FY 2005. The Electromagnetics and Sensors Branch (ESB) developed three ultra lightweight antenna concepts compatible with HALE UAVs (High Altitude Long Endurance Unmanned Aerial Vehicles). ESB also developed antenna elements that minimize the interaction between elements and the vehicle to minimize the impact of wing flexure on the EM (electromagnetic) performance of the integrated array. In addition, computer models were developed to perform phase correction for antenna arrays whose elements are moving relative to each other due to wing deformations expected in HALE vehicle concepts. Development of lightweight, conformal or structurally integrated antenna elements and compensating for the impact of a lightweight, flexible structure on a large antenna array are important steps in the realization of HALE UAVs for microwave applications such as passive remote sensing and communications.

  10. Simulations for the Test Flight of an Experimental HALE Aircraft

    DTIC Science & Technology

    2011-06-01

    as a plant representation for HALE aircraft control design. It focuses on a reduced number of states to represent the complex nonlinear problem...Atkins, Ella M., Shearer, Christopher M. and Nathan A. Pitcher . “X-HALE: A Very Flexible UAV for Nonlinear Aeroelastic Tests.” (AIAA 2010-2715), April

  11. Current Hale ROA Voice and Control Communication Practices and Performance: White Paper

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The objective of this white paper is to help achieve the ACCESS 5 goal by sharing the UNITE members knowledge of current HALE ROA communication systems with other ACCESS 5 participants so that all interested parties start from a common understanding as we begin the clarification of requirements for voice and C2 communication. This white paper is also intended to describe the point of departure for any future developments that need to be realized to achieve the long term ACCESS 5 goal. Although this white paper describes the current systems, the functional and performance requirements that are also being developed under ACCESS 5 may not require the same levels of functionality and performance as currently exist. The paper addresses the following: 1) A description of a typical current HALE ROA communications system, 2) HALE ROA communications systems performance metrics, 3) HALE ROA communications systems performance, and 5) A comparison of current HALE ROA communications systems with current regulations.

  12. RE-EXAMINING SUNSPOT TILT ANGLE TO INCLUDE ANTI-HALE STATISTICS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McClintock, B. H.; Norton, A. A.; Li, J., E-mail: u1049686@umail.usq.edu.au, E-mail: aanorton@stanford.edu, E-mail: jli@igpp.ucla.edu

    2014-12-20

    Sunspot groups and bipolar magnetic regions (BMRs) serve as an observational diagnostic of the solar cycle. We use Debrecen Photohelographic Data (DPD) from 1974-2014 that determined sunspot tilt angles from daily white light observations, and data provided by Li and Ulrich that determined sunspot magnetic tilt angle using Mount Wilson magnetograms from 1974-2012. The magnetograms allowed for BMR tilt angles that were anti-Hale in configuration, so tilt values ranged from 0 to 360° rather than the more common ±90°. We explore the visual representation of magnetic tilt angles on a traditional butterfly diagram by plotting the mean area-weighted latitude ofmore » umbral activity in each bipolar sunspot group, including tilt information. The large scatter of tilt angles over the course of a single cycle and hemisphere prevents Joy's law from being visually identified in the tilt-butterfly diagram without further binning. The average latitude of anti-Hale regions does not differ from the average latitude of all regions in both hemispheres. The distribution of anti-Hale sunspot tilt angles are broadly distributed between 0 and 360° with a weak preference for east-west alignment 180° from their expected Joy's law angle. The anti-Hale sunspots display a log-normal size distribution similar to that of all sunspots, indicating no preferred size for anti-Hale sunspots. We report that 8.4% ± 0.8% of all bipolar sunspot regions are misclassified as Hale in traditional catalogs. This percentage is slightly higher for groups within 5° of the equator due to the misalignment of the magnetic and heliographic equators.« less

  13. Seasonal Flows in the Central Mountains of Hale Crater

    NASA Image and Video Library

    2015-04-08

    Recurring slope lineae are active flows on warm Martian slopes that might be caused by seeping water. One of the most active sites known is in the central peaks of Hale Crater as seen by NASA Mars Reconnaissance Orbiter. This image shows RSL extending downhill from bedrock cliffs, mostly towards the northwest (upper left). This image was acquired in middle summer when RSL are most active in the southern mid latitudes. The RSL in Hale have an unusually "reddish" color compared to most RSL, perhaps due to oxidized iron compounds, like rust. Since HiRISE color is shifted to infra-red wavelengths, they are actually especially bright the near-infrared just beyond the range of human vision. The Hale RSL are also unusual because they began activity much earlier than most RSL sites in the middle southern latitudes, and were well-developed in the early spring (see ESP_038073_1440). If seeping water causes RSL in Hale crater, it must be rich in salts to lower its freezing point significantly below the freezing point of pure water. http://photojournal.jpl.nasa.gov/catalog/PIA19359

  14. Web life: Wayne Hale's Blog

    NASA Astrophysics Data System (ADS)

    2012-08-01

    A former NASA engineer, Hale began his career at the US space agency in 1978 as a propulsion specialist, became a flight director during the Space Shuttle era, and went on to lead the entire shuttle programme after the loss of the shuttle Columbia in February 2003.

  15. George Ellery Hale's Early Solar Research at Chicago, Kenwood, Harvard, and Yerkes Observatories, 1882-1904

    NASA Astrophysics Data System (ADS)

    Osterbrock, D. E.

    1999-05-01

    Growing up in Chicago, George Ellery Hale, later the prime spirit in founding the AAS, was a precocious boy scientist. He was deeply interested in spectroscopy and astrophysics from an early age. His wealthy parents encouraged Hale's aspirations with magazines, books, and instruments, and he acquired his first telescope when he was 14. He knew as mentors classical astronomers S. W. Burnham and George W. Hough, but he preferred astrophysics and designed his own Kenwood Physical Obseervatory around a grating in a Rowland circle mounting, fed by a heliostat, both built for him by instrument-maker John A. Brashear. For his undergraduate thesis at MIT, Hale invented and (at Harvard College Observatory) demonstrated the spectroheliograph. With it, and a high-quality 12-in refractor at his later Kenwood Astrophysical Observatory (at the same site, the Hale family home, 4 miles from the present Hilton Hotel where the SPD, HAD and AAS are meeting) Hale did excellent solar research, especially on promineneces, flocculi, and the near-ultraviolet spectrum of the chromosphere. As a teen-ager and a young adult Hale traveled widely, and met several important piuoneer solar physicists, including Charles A. Young, Jules Janssen, Samuel P. Langley, and Henry Rowland. Hale designed Yerkes Observatory for solar and stellar research, and headed the solar work himself. One of his aims always was to compare other stars with the sun. Hale's telescopes, instruments, methods, and resulting papers will be described and illustrated by numerous slides.

  16. ISO's analysis of Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    1997-03-01

    The European Space Agency's Infrared Space Observatory ISO inspected Comet Hall-Bopp during the spring and autumn of 1996. The need to keep ISO's telescope extremely cold restricts the spacecraft's pointing in relation to the Sun and the Earth and it ruled out observations at other times. The analyses of the 1996 observations are not yet complete, but already they give new insight into the nature of comets. Comet Hale-Bopp is believed to be a large comet with a nucleus up to 40 kilometres wide. It was discovered in July 1995 by two American astronomers working independently, Alan Hale and Thomas Bopp. At that time, the comet was a billion kilometres away from the Sun, but 200 times brighter than Halley's Comet was, when at a comparable distance. Comet Hale-Bopp will make its closest approach to the Earth on 22 March, and its closest approach to the Sun (perihelion) on 1 April 1997. Some scientific results from ISO The discovery of Comet Hale-Bopp occurred before ISO's launch in November 1995. When first observed by ISO in March and April 1996, the comet was still 700 million kilometres from the Sun, and almost as far from the Earth and ISO. With its privileged view of infrared wavebands inaccessible from the Earth's surface, ISO's photometer ISOPHOT discovered that carbon dioxide was an important constituent of the comet's emissions of vapour.ISOPHOT measured the temperature of the dust cloud around Comet Hale-Bopp. In March 1996, when the comet was still more than 700 million kilometres from the Sun, the dust cloud was at minus 120 degrees C. When ISOPHOT made similar observations in October 1996, the comet was 420 million kilometres from the Sun, and the dust cloud had warmed to about minus 50 degrees C. Intensive observations of Comet Hale-Bopp were also made by ISO's Short-Wave Spectrometer SWS, the Long-Wave Spectrometer LWS, and the ISOPHOT spectrometer PHOT-S. Results are due for publication at the end of March. They will give details about the composition

  17. A solar module fabrication process for HALE solar electric UAV's

    NASA Astrophysics Data System (ADS)

    Carey, P. G.; Aceves, R. C.; Colella, N. J.; Williams, K. A.; Sinton, R. A.; Glenn, G. S.

    1994-12-01

    We describe a fabrication process used to manufacture high power-to-weight-ratio flexible solar array modules for use on high-altitude-long-endurance (HALE) solar-electric unmanned air vehicles (UAV's). These modules have achieved power-to-weight ratios of 315 and 396 W/kg for 150 micron-thick monofacial and 110 micron-thick bifacial silicon solar cells, respectively. These calculations reflect average module efficiencies of 15.3% (150 micron) and 14.7% (110 micron) obtained from electrical tests performed by Spectrolab, Inc. under AMO global conditions at 25 C, and include weight contributions from all module components (solar cells, lamination material, bypass diodes, interconnect wires, and adhesive tape used to attach the modules to the wing). The fabrication, testing, and performance of 32 sq m of these modules is described.

  18. Electron impact excitation of carbon monoxide in comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Campbell, L.; Brunger, M. J.

    2009-02-01

    The fourth positive emissions of carbon monoxide in the coma of comet Hale-Bopp have been assumed to be due mainly to fluorescence induced by sunlight. Based on this assumption they were used to deduce the abundance of carbon monoxide in the comet, giving a value higher than in other comets. Emissions produced by electron impact excitation of CO were not considered. Recent measurements and theoretical calculations of integral cross sections for electron impact excitation of CO allow the contribution of electron impact to be calculated, giving about 40% of the total. This implies that the abundance of CO in the outer coma of comet Hale-Bopp was only 60% of that previously deduced. However, as the high proportion of CO in comet Hale-Bopp was also seen in some other measurements, alternative explanations are considered. The method of calculation is tested by successfully predicting the O I emission at 1356 Å, supporting the belief that this line is due to electron impact excitation.

  19. Measurements of [C I] Emission from Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Oliversen, R. J.; Doane, N.; Scherb, F.; Harris, W. M.; Morgenthaler, J. P.

    2002-12-01

    We present quantitative measurements of cometary [C I] 9850 Å emission obtained during observations of comet Hale-Bopp (C/1995 O1) in 1997 March and April. The observations were carried out using a high-resolution (λ/Δλ~40,000) Fabry-Pérot/CCD spectrometer at the McMath-Pierce Solar telescope on Kitt Peak. This forbidden line, the carbon analog of [O I] 6300 Å, is emitted in the radiative decay of C(1D) atoms. In the absence of other sources and sinks, [C I] 9850 Å emission can be used as a direct tracer of CO photodissociation in comets. However, in Hale-Bopp's large, dense coma, other processes, such as collisional excitation of ground-state C(3P), dissociative recombination of CO+, and collisional dissociation of CO and CO2 may produce significant amounts of C(1D). The long C(1D) radiative lifetime (~4000 s) makes collisional deexcitation (quenching) the primary loss mechanism in the inner coma. Thus, a detailed, self-consistent global model of collisional and photochemical interactions is necessary to fully account for [C I] 9850 Å emission in comet Hale-Bopp.

  20. Hales discontinuity beneath India: selective appearance and a case for systematic modeling

    NASA Astrophysics Data System (ADS)

    Mitra, S.; Chaudhury, J.

    2016-12-01

    Hales discontinuity was first reported in Lake Superior at depth of 80-90 km, characterized by an increase in P-wave velocity from 8.05 to 8.45 km/s. Subsequent, worldwide studies have observed this discontinuity beneath selected continental regions and Pacific Ocean, with depth varying from 40 to 115 km. The cause for the absence of observable signal corresponding to the Hales discontinuity beneath a number of seismic stations and the large depth variation of the discontinuity are poorly understood. In the Indian subcontinent, the Hales discontinuity has been selectively imaged beneath the Southern Granulite Terrain, Eastern Dharwar, Bastar and Aravalli Cratons. These studies used low frequency P-wave receiver functions (P-RFs) to show that the Hales discontinuity corresponds to a PHs phase arriving between 7.5 and 11 s. A few studies have forwarded modeled this phase to demonstrate that this arrival is distinct from Moho reverberations and corresponds to a depth range of 75-90 km. However, these studies have ignored the effect of mid-crustal discontinuity, which had been observed in P-RF inverted crustal models beneath these stations, and its first reverberation coincide with the reported PHs. We demonstrate through forward modeling that the observed Hales discontinuity PHs can be matched by the PpPs from mid-crustal discontinuity beneath the cratons, with the exception of Hyderabad (HYB), where this discontinuity was reported to be deepest at 90 km. We perform joint inversion of the HYB P-RFs with Rayleigh wave dispersion to obtain a 32 km thick two layer crust, and Hales discontinuity at a depth of 108±2 km, with 4% increase in S-wave velocity from 4.6 to 4.8 km/s. Several mechanisms have been proposed to explain this velocity discontinuity, which include transition from spinel to garnet peridotite or changes in cation partitioning in olivine. We intend to evaluate the velocity increase based on thermoelasticity data of minerals constituting peridotite.

  1. HALE UAS Concept of Operations. Version 3.0

    NASA Technical Reports Server (NTRS)

    2006-01-01

    This document is a system level Concept of Operations (CONOPS) from the perspective of future High Altitude Long Endurance (HALE) Unmanned Aircraft Systems (UAS) service providers and National Airspace System (NAS) users. It describes current systems (existing UAS), describes HALE UAS functions and operations to be performed (via sample missions), and offers insight into the user s environment (i.e., the UAS as a system of systems). It is intended to be a source document for NAS UAS operational requirements, and provides a construct for government agencies to use in guiding their regulatory decisions, architecture requirements, and investment strategies. Although it does not describe the technical capabilities of a specific HALE UAS system (which do, and will vary widely), it is intended to aid in requirements capture and to be used as input to the functional requirements and analysis process. The document provides a basis for development of functional requirements and operational guidelines to achieve unrestricted access into the NAS. This document is an FY06 update to the FY05 Access 5 Project-approved Concept of Operations document previously published in the Public Domain on the Access 5 open website. This version is recommended to be approved for public release also. The updates are a reorganization of materials from the previous version with the addition of an updated set of operational requirements, inclusion of sample mission scenarios, and identification of roles and responsibilities of interfaces within flight phases.

  2. Sarah J. Hale High School-Project SABER.

    ERIC Educational Resources Information Center

    Rosenblatt, Harold

    Project SABER, which operated in Sarah J. Hale High School in South Brooklyn, New York, consisted of bilingual instructional and supportive services to 9th and 10th grade Spanish language students. Students received bilingual instruction in social studies, science, math, and Spanish. All the SABER students received English as a second language…

  3. What's New With Hale Bopp?

    NASA Astrophysics Data System (ADS)

    Shylaja, B. S.

    1997-06-01

    The comet Hale-Bopp has provided a great opportunity to astrophysicists. It is bright and it has been available for observations for a long period of time. A good number of large telescopes all over the northern hemisphere have been deployed for observations of this comet. Within a month of its discovery came the first result that the comet was quite active even when it was beyond Jupiter. Jets of gas and dust continued to stream out one after the other. This created the suspicion that the magnitude estimates may turn out to be only the limits rather than the actual values. The anxiety, so created disappeared only when the comet reached the visibility limits in late 1996. By the time it reached the perihelion on April 1, it was not fooling around anymore and kept up the promise of a 'civilized comet', the one that could be located without a finding chart. As is well known, the magnitude after the perihelion passage, would be slightly higher than the estimated value. The two-tail structure was first noticed a few months prior to the perihelion. The gradation in colour from blue of the ion tail to yellow of the dust tail was quite conspicuous. A simple binocular could easily resolve the two. Interestingly, just after the perihelion, there was a flare and the associated storm on the sun due to which a temporary increase in the solar wind particle density can occur. It would be extremely interesting to find the related effects on the tail, especially on the ion component. The solar and cometary physicists are (as on April 26th) eagerly looking forward to monitoring the changes. The ion tail has grown to about 15 degrees in the sky and is expected to get disrupted after the solar storm. On the other hand, the dust tail which grew to a full length of 45 degrees offered a glorious sight in the evening sky. The new moon at the time of perihelion enhanced the spectacle. In the middle of April quite suddenly, a third tail, a sharp yellow one, showed up. This was attributed

  4. Measurements of [C I] 9850 A Emission from Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Oliversen, R. J.; Doane, N.; Scherb, F.; Harris, W. M.; Morgenthaler, J. P.

    2002-01-01

    We present quantitative measurements of cometary [C I] 9850 A, emission obtained during observations of comet Hale-Bopp (C/1995 O1) in 1997 March and April. The observations were carried out using a high-resolution (lambda/Delta lambda approx. 40,000) Fabry-Perot/CCD spectrometer at the McMath-Pierce solar telescope on Kitt Peak. This forbidden line, the carbon analog of [O I] 6300 A, is emitted in the radiative decay of C(1D) atoms. In the absence of other sources and sinks, [C I] 9850 A emission may be used as a direct tracer of CO photodissociation in comets. However, in Hale-Bopp's large, dense coma, other processes, such as collisional excitation of ground-state C(3P), dissociative recombination of CO+, and collisional dissociation of CO and CO2 may produce significant amounts of C(1D). The long C(1D) radiative lifetime (approx. 4000 s) makes collisional de-excitation (quenching) the primary loss mechanism in the inner coma. Thus, a detailed, self-consistent global model of collisional and photochemical interactions is necessary to fully account for [C I] 9850 A emission in comet Hale-Bopp.

  5. Modeling Coma Gas Jets in Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Lederer, S. M.; Campins, H.

    2001-01-01

    We present an analysis of OH, CN, and C2 jets observed in Comet Hale-Bopp. The relative contributions from and composition of the coma gas sources, and the parameters describing the active areas responsible for the gas jets will be discussed. Additional information is contained in the original extended abstract.

  6. New Observations of Comet Hale-Bopp from La Silla

    NASA Astrophysics Data System (ADS)

    1998-10-01

    Methanol and Hydrogen Cyanide Detected at Record Distance Observations of famous Comet Hale-Bopp continue with the 15-m Swedish-ESO Submillimetre Telescope (SEST) at the La Silla Observatory. They show amazingly strong activity of this unusual object, also at the present, very large distance from the Sun. The radio observations document in detail the release of various molecules from the comet's icy nucleus. Of particular interest is the observed emission from methanol ( CH 3 OH ) and hydrogen cyanide ( HCN ) molecules, never before detected in any comet this far away. Comet Hale-Bopp still going strong Just over 18 months after its perihelion passage on April 1, 1997, Comet Hale-Bopp (official designation C/1995 O1 ) is continuing its outward journey through the Solar System. It is now about 1,000 million kilometres (6.7 AU) from the Sun and the Earth, i.e. almost at the same distance as when it was first discovered in July 1995. After having traversed the northern sky in 1996 and 1997, the comet passed the celestial equator in late June 1997 and is now seen in the southern constellation Volans (The Flying Fish), i.e. just east of the Large Magellanic Cloud. It can only be observed from southern latitudes. The comet's brightness has decreased by a factor of more than 10,000 since it was at its brightest in March 1997, just before perihelion. However, the magnitude is still around 9 - 10, or only about 20-40 times fainter than what can be seen with the unaided eye. Hale-Bopp is therefore visible in binoculars to southern observers as a fuzzy object with a diameter of a few arcminutes. New observations from La Silla Several telescopes at La Silla are following the evolution of the activity of Comet Hale-Bopp as it recedes from the Sun. In particular, the comet is observed monthly with SEST , a 15-m diameter submillimetre telescope operated jointly by the Onsala Space Observatory (OSO, Chalmers University of Technology, Gothenburg, Sweden) and ESO; it is the only

  7. Seismology at the Australian National University; an interview with Anton L. Hales

    USGS Publications Warehouse

    Spall, H.

    1980-01-01

    Dr. Anton L. Hales is a leading seismologist who has just retired as Director of the Research School of Earth Sciences at the Australian National University (ANU), Canberra. Prior to that, he headed the Geosciences Division at the University of Texas at Dallas, and, before that, he was Director of the Bernard Price Institute of Geophysical Research at the University of the Witwatersrand Johannesburg, South Africa. he is about to step down as President of the International Geodynamics Commission. Dr. Hales' research has involved marine geophysics, the travel times of seismic waves, and the structure of the Earth's crust and upper mantle. 

  8. Abundant Cool Magnesium-Rich Pyroxene Crystals in Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Wooden, D. H.

    1999-01-01

    Modeling of the observed dust emission from Comet Hale-Bopp over a large range of heliocentric distances (2.8 AU - 0.93 AU -1.7 AU) led to the discovery of Mg-rich pyroxene crystals in the coma These pyroxene crystals are apparent in the 10 micron spectrum only when the comet is close to perihelion (r(sub h) = 1.2 AU) because they are cooler than the other silicate minerals. The pyroxene crystals are cooler than the other species because of their high Mg-content. They do not absorb as efficiently as the other silicate minerals. Given the same high Mg content of Mg/(Mg + Fe) = 0.9, radiative equilibrium computations show that pyroxene crystals are expected to be 150 K cooler than olivine crystals. The pyroxene crystals are also about 10x more abundant than the other silicate mineral species. Their high Mg content and relatively large abundance are in agreement with the preponderance of pyroxene interplanetary dust particles (IDPs) and the recent reanalysis of the PUMA-I flyby of Comet Halley. Before Hale-Bopp, only olivine crystals were detected spectroscopically in comets, probably because the pyroxene crystals are less optically active, hence significantly cooler and harder to detect in contrast to the warmer silicate species. Determining the relative abundances of silicate minerals depends on their Mg contents. If the pyroxene crystals in Comet Hale-Bopp are solar nebula condensates, then they probably had to form during the early FU Orionis epoch when the inner disk was hot enough and be transported out to the region of formation of icy planetesimals without being reheated. Reheating events appear to reincorporate Fe back into the crystals or form Fe-rich rims, which are not consistent with the high-Mg-content crystals. The condensation of Mg-rich pyroxene crystals is expected from solar nebula thermal equilibrium computations. However, their subsequent transport to the outer solar nebula unaltered has yet to be theoretically demonstrated. The discovery of Mg

  9. Collisional quenching of OH radio emission from comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Schloerb, F. P.; Devries, C. H.; Lovell, A. J.; Irvine, W. M.; Senay, M.; Wootten, H. A.; Ferris, J. P. (Principal Investigator)

    1997-01-01

    Observations of comets in the 18-cm OH transitions offer a means to probe gas production, kinematics, and OH excitation in comets. We present initial results of OH observations of comet Hale-Bopp obtained with the NRAO 43 m antenna located in Greenbank, WV. Maps of the emission provide strong constraints on the amount of quenching of the inversion of the OH ground state A-doublet in the coma. Analysis of the total radio OH flux and maps of its radial brightness distribution indicate a quenched region on the order of approximately 500,000 km during March and April 1997. This large value is generally consistent with previous observations of radio OH quenching in lower production rate comets when the high production rate of comet Hale-Bopp is considered.

  10. New methods for deriving cometary secular light curves: C/1995 O1 (Hale-Bopp) revisited

    NASA Astrophysics Data System (ADS)

    Womack, Maria; Lastra, Nathan; Harrington, Olga; Curtis, Anthony; Wierzchos, Kacper; Ruffini, Nicholas; Charles, Mentzer; Rabson, David; Cox, Timothy; Rivera, Isabel; Micciche, Anthony

    2017-10-01

    We present an algorithm for reducing scatter and increasing precision in a comet light curve. As a demonstration, we processed apparent magnitudes of comet Hale-Bopp from 16 highly experienced observers (archived with the International Comet Quarterly), correcting for distance from Earth and phase angle. Different observers tend to agree on the difference in magnitudes of an object at different distances, but the magnitude reported by observer is shifted relative to that of another for an object at a fixed distance. We estimated the shifts using a self-consistent statistical approach, leading to a sharper light curve and improving the precision of the measured slopes. The final secular lightcurve for comet Hale-Bopp ranges from -7 au (pre-perihelion) to +8 au (post-perihelion) and is the best secular light curve produced to date for this “great” comet. We discuss Hale-Bopp’s lightcurve evolution and possibly related physical implications, and potential usefulness of this light curve for comparisons with other future bright comets. We also assess the appropriateness of using secular lightcurves to characterize dust production rates in Hale-Bopp and other dust-rich comets. M.W. acknowledges support from NSF grant AST-1615917.

  11. The Hale-Bopp comet - an unexpected guest

    NASA Astrophysics Data System (ADS)

    Gorodetchi, Dumitru

    A number of 3 photographs are given of the comewt Hale-Bopp made at UT 1997 March 18.0937 (refractor RT-80(80 cm., 1:10); Fomapan T-800 (DT=10 min). 2) UT 1997 March 18.010; Cassegrain-reflector AT -400 (630, 1:16); film 100 ASA (DT=1 min) 3)UT 1997 April 5.8097; telobiectiv Tair -11 (13,5 cm, 1:2.8); Fomapan T-800 (DT =2 min)

  12. HALE STAIN FOR SIALIC ACID-CONTAINING MUCINS. ADAPTATION TO ELECTRON MICROSCOPY.

    PubMed

    GASIC, G; BERWICK, L

    1963-10-01

    The feasibility of using the Hale stain to identify cellular sialic acid-containing mucins by electron microscopy was investigated. Three kinds of mouse ascites tumor cells were fixed in neutral buffered formalin, exposed to fresh colloidal ferric oxide, treated with potassium ferrocyanide, imbedded in Selectron, and sectioned for electron microscopy. Additional staining with uranyl acetate and potassium permanganate was done after sectioning in order to increase contrast. Those cells known to be coated with sialomucin showed deposits of electron-opaque ferric ferrocyanide crystals in the areas where sialomucin concentrations were expected. When these cells were treated with neuraminidase beforehand, these deposits did not appear. It was concluded that, with the precautions and modifications described, the Hale stain can be successfully combined with electron microscopy to identify sialomucin.

  13. Hubble Sees Material Ejected From Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    1995-01-01

    These NASA Hubble Space Telescope pictures of comet Hale-Bopp show a remarkable 'pinwheel' pattern and a blob of free-flying debris near the nucleus. The bright clump of light along the spiral (above the nucleus, which is near the center of the frame) may be a piece of the comet's icy crust that was ejected into space by a combination of ice evaporation and the comet's rotation, and which then disintegrated into a bright cloud of particles.

    Although the 'blob' is about 3.5 times fainter than the brightest portion at the nucleus, the lump appears brighter because it covers a larger area. The debris follows a spiral pattern outward because the solid nucleus is rotating like a lawn sprinkler, completing a single rotation about once per week.

    Ground-based observations conducted over the past two months have documented at least two separate episodes of jet and pinwheel formation and fading. By coincidence, the first Hubble images of Hale-Bopp, taken on September 26, 1995, immediately followed one of these outbursts and allow researchers to examine it at unprecedented detail. For the first time they see a clear separation between the nucleus and some of the debris being shed. By putting together information from the Hubble images and those taken during the recent outburst using the 82 cm telescope of the Teide Observatory (Tenerife, Canary Islands, Spain), astronomers find that the debris is moving away from the nucleus at a speed (projected on the sky) of about 68 miles per hour (109 kilometers per hour).

    The Hubble observations will be used to determine if Hale-Bopp is really a giant comet or rather a more moderate-sized object whose current activity is driven by outgassing from a very volatile ice which will 'burn out' over the next year. Comet Hale-Bopp was discovered on July 23, 1995 by amateur astronomers Alan Hale and Thomas Bopp. Though this comet is still well outside the orbit of Jupiter (almost 600 million miles, or one billion kilometers from Earth

  14. How leaders self-regulate their task performance: evidence that power promotes diligence, depletion, and disdain.

    PubMed

    DeWall, C Nathan; Baumeister, Roy F; Mead, Nicole L; Vohs, Kathleen D

    2011-01-01

    When leaders perform solitary tasks, do they self-regulate to maximize their effort, or do they reduce effort and conserve their resources? Our model suggests that power motivates self-regulation toward effective performance-unless the task is perceived as unworthy of leaders. Our 1st studies showed that power improves self-regulation and performance, even when resources for self-regulation are low (ego depletion). Additional studies showed that leaders sometimes disdain tasks they deem unworthy, by withholding effort (and therefore performing poorly). Ironically, during ego depletion, leaders skip the appraisal and, therefore, work hard regardless of task suitability, so that depleted leaders sometimes outperform nondepleted ones. Our final studies replicated these patterns with different tasks and even with simple manipulation of framing and perception of the same task (Experiment 5). Experiment 4 also showed that the continued high exertion of leaders when depleted takes a heavy toll, resulting in larger impairments later. The judicious expenditure of self-control resources among powerful people may help them prioritize their efforts to pursue their goals effectively. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  15. Recurring Lineae on Slopes at Hale Crater, Mars

    NASA Image and Video Library

    2015-09-28

    Dark, narrow streaks on Martian slopes such as these at Hale Crater are inferred to be formed by seasonal flow of water on contemporary Mars. The streaks are roughly the length of a football field. The imaging and topographical information in this processed, false-color view come from the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter. These dark features on the slopes are called "recurring slope lineae" or RSL. Planetary scientists using observations with the Compact Reconnaissance Imaging Spectrometer on the same orbiter detected hydrated salts on these slopes at Hale Crater, corroborating the hypothesis that the streaks are formed by briny liquid water. The image was produced by first creating a 3-D computer model (a digital terrain map) of the area based on stereo information from two HiRISE observations, and then draping a false-color image over the land-shape model. The vertical dimension is exaggerated by a factor of 1.5 compared to horizontal dimensions. The camera records brightness in three wavelength bands: infrared, red and blue-green. The draped image is one product from HiRISE observation ESP_03070_1440. http://photojournal.jpl.nasa.gov/catalog/PIA19916

  16. Comparative Study of Wing Lift Distribution Analysis for High Altitude Long Endurance (HALE) Unmaned Aerial Vehicle

    NASA Astrophysics Data System (ADS)

    Silitonga, Faber Y.; Agoes Moelyadi, M.

    2018-04-01

    The development of High Altitude Long Endurance (HALE) Unmanned Aerial Vehicle (UAV) has been emerged for both civil and military purposes. Its ability of operating in high altitude with long endurance is important in supporting maritime applications.Preliminary analysis of HALE UAV lift distribution of the wing presented to give decisive consideration for its early development. Ensuring that the generated lift is enough to compensate its own weight. Therotical approach using Pradtl’s non-linear lifting line theory will be compared with modern numerical approach using Computational Fluid Dynamics (CFD). Results of wing lift distribution calculated from both methods will be compared to study the reliability of it. HALE UAV ITB has high aspect ratio wing and will be analyze at cruise flight condition. The result indicates difference between Non-linear Lifting Line and CFD method.

  17. Rocket Detection of Argon in Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Stern, S. A.; Festou, M. C.; Parker, J. Wm.; Slater, D. C.; Gladstone, G. R.; A'Hearn, M. F.

    1998-12-01

    The EUVS planetary sounding rocket spectrograph was flown on 30.2 March 1997 (UT) from White Sands, New Mexico to observe comet Hale-Bopp in the bandpass from 830--1120 A. At the time of launch the comet was near perihelion, 0.915 AU from the Sun, 1.340 AU from Earth, and traveling at a heliocentric radial velocity of +0.70 km/s. EUVS obtained its primary spectra of the comet at resolution near 12 A, collecting 9340 counts over approximately 330 seconds of integration time. To our knowledge, the resulting dataset is both the most sensitive and the highest spectral resolution probe of a comet in the UV below 1200 A as yet achieved, and contains signatures of both the 1048.2 A and 1066.7 A Ar I resonance lines. These features represent the first-ever detections of any noble gas in a comet. The spectrum also includes significant detections which we tentatively attribute to due to 834 A 0 II, 972 A Lyman gamma, 989 A O I, the 1026 A H I Lyman beta/O I. We will discuss the Ar features, retrieve the Ar column in the coma, and discuss the implications of the total Ar/O abundance ratio in Hale-Bopp for the comet's origin.

  18. Spectrophotometry of Dust in Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Witteborn, Fred C. (Technical Monitor)

    1997-01-01

    Comets, such as Hale-Bopp (C/1995 O1), are frozen reservoirs of primitive solar nebula dust grains and ices. Analysis of the composition of cometary dust grains from infrared spectroscopic techniques permits an estimation of the types of organic and inorganic materials that constituted the early primitive solar nebula. In addition, the cometary bombardment of the Earth (approximately 3.5 Gy ago) supplied the water for the oceans and brought organic materials to Earth which may have been biogenic. Spectroscopic observations of comet Hale-Bopp suggest the possible presence of organic hydrocarbon species, silicate and olivine dust grains, and water ice. Spectroscopy near 3 microns obtained in Nov 1996 r=2.393 AU, delta=3.034 AU) shows a feature which we attribute to PAH emission. The spatial morphology of the 3.28 microns PAH feature is also presented. Optical and infrared spectrophotometric observations of comets convey valuable information about the spatial distribution and properties of dust and gas within the inner coma. In the optical and NIR shortward of 2 microns, the observed light is primarily scattered sunlight from the dust grains. At longer wavelengths, particularly in the 10 gm window, thermal emission from these grains dominates the radiation allowing an accurate estimate of grain sizes and chemical composition. Here we present an initial analysis of spectra taken with the NASA HIFOGS at 7-14 microns as part of a multiwavelength temporal study of the "comet of the century".

  19. The Wisconsin/GSFC Hale-Bopp Observing Campaign

    NASA Astrophysics Data System (ADS)

    Scherb, F.; Roesler, F. L.; Harris, W. M.; Nordsieck, K. H.; Anderson, C.; Klinglesmith, D. A., III; Woodward, R. C.; Mierkiewicz, E. J.; Haffner, L. M.; Tufte, S. L.; Oliversen, R. J.; Hilton, G. M.; Doane, N.; Tilleman, T.; Vincent, M.

    1997-07-01

    From September 1996 to April 1997, we conducted an extensive campaign of observations of several atomic (O, C, H), ionic (H_2O(+) ), and molecular (OH, C_2, C_3, CN, NH_2) emissions from Comet Hale-Bopp, using a variety of telescopes (McMath-Pierce, WHAM, Burrel-Schmidt, WIYN, PBO, WISP), instruments (imagers, Fabry-Perot and grating spectrometers, polarimeters), and data formats (spectra, images, datacubes). We will present an overview of the observations, and highlight early results, some of which will be presented in detail in poster papers at this meeting.

  20. Hale Boggs on J. Edgar Hoover: Rhetorical Choice and Political Denunciation.

    ERIC Educational Resources Information Center

    Gibson, Dirk

    This paper examines United States Representative Hale Boggs's 1971 speech on the House floor, in which he denounced J. Edgar Hoover and the Federal Bureau of Investigation (FBI) for wiretapping members of Congress and infiltrating campus student groups. Following an introduction to the objectives of the paper, the first section reviews Boggs's…

  1. Breaking through "The Dominion of Facts": Sarah Josepha Hale's Instructive Legacy.

    ERIC Educational Resources Information Center

    Henning, Martha L.

    The 18th and 19th centuries saw a real tension between inductive and deductive methods of reason. Spokesperson for her era through her association with the popular "Godey's Ladies' Book," Sarah Josepha Hale addressed this tension in 1858, citing an article by Thomas Henry Buckle ascribing the method of deduction to women and that of induction to…

  2. The 830--1120 A Spectrum of a Bright Comet: First Results on Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Stern, S. Alan; Festou, Michel C.; Slater, David C.; Parker, Joel Wm.; A'Hearn, Michael F.

    1998-09-01

    The EUVS planetary sounding rocket spectrograph was flown on 29 March 1997 from White Sands, New Mexico to observe comet Hale-Bopp in the bandpass from 830--1120 Angstroms. At the time of launch the comet was near perihelion, 0.92 AU from the Sun, 1.34 AU from Earth, and traveling at a heliocentric radial velocity of +0.70 km/s. EUVS obtained its primary spectra of the comet at resolution near 3 Angstroms, collecting 9340 counts over approximately 330 seconds of integration time. To our knowledge, the resulting dataset is both the most sensitive and the highest spectral resolution probe of a comet in the UV below 1200 Angstroms yet achieved. The spectrum includes significant detections which we tentatively attribute to due to 834 Angstroms 0 II, the 1026 Angstroms H I Lyman beta /O I blend, and 989 Angstroms O I; we will also discuss evidence for Argon signatures, as well as two additional, yet to be identified features. We will describe the EUVS Hale-Bopp experiment and its results, including feature brightnesses, corresponding columns, and species abundance ratios in the inner coma. In addition to its value for providing insight into comets in general, and Hale-Bopp in particular, this spectrum is serving as an excellent input for New Millennium Deep Space 1/MICAS and Rosetta/ALICE UV observation planning below 1200 Angstroms.

  3. Seismological evidence of the Hales discontinuity in northeast India

    NASA Astrophysics Data System (ADS)

    Anand, Aakash; Bora, Dipok K.; Borah, Kajaljyoti; Madhab Borgohain, Jayanta

    2018-04-01

    The crust and upper mantle shear wave velocity structure beneath the northeast India is estimated by joint inversion of Rayleigh wave group velocity and receiver function, calculated from teleseismic earthquakes data recorded at nine broadband seismic stations. The Assam valley and the Shillong-Mikir plateau are the two important tectonic blocks in the northeast India, which are surrounded by the Himalayan collision zone in the north, Indo-Burma subduction zone in the east and by the Bengal basin in the south. The joint inversion followed by forward modeling reveal crustal thicknesses of 30-34 km beneath the Shillong plateau, 36 km beneath the Mikir hills and 38-40 km beneath the Assam valley with an average shear wave velocity (Vs) of 3.4-3.5 km/s. The estimated low upper mantle shear wave velocity (Vsn) 4.2-4.3 km/s may be due to the rock composition or grain size or increased temperature and partial melt (<1%) in the upper mantle, or an effect of all. Also, we report for the first time, the existence of the Hales discontinuity at depths 56-74 km with Vs ∼4.4-4.6 km/s. Variable depth of the Hales discontinuity may be explained by the geotherm and/or addition of Cr3+ and Fe2+ in the spinel-garnet system.

  4. Aerodynamic Analysis of a Hale Aircraft Joined-Wing Configuration

    NASA Astrophysics Data System (ADS)

    Sivaji, Rangarajan; Ghia, Urmila; Ghia, Karman; Thornburg, Hugh

    2003-11-01

    Aerodynamic analysis of a high-aspect ratio, joined wing of a High-Altitude Long Endurance (HALE) aircraft is performed. The requirement of high lift over extended flight periods for the HALE aircraft leads to high-aspect ratio wings experiencing significant deflections necessitating consideration of aeroelastic effects. The finite-volume solver COBALT, with Reynolds-averaged Navier-Stokes (RANS) and Detached Eddy Simulation (DES) capabilities, is used for the flow simulations. Calculations are performed at á = 0° and 12° for M = 0.6, at an altitude of 30,000 feet, at a Re per unit length of 5.6x106. The wing cross sections are NACA 4421 airfoils. Because of the high lift-to-drag ratio wings, an inviscid flow analysis is also performed. The inviscid surface pressure coefficient (Cp) is compared with the corresponding viscous Cp to examine the feasibility of the use of the inviscid pressure loads as an estimate of the total fluid loads on the structure. The viscous and inviscid Cp results compare reasonably only at á = 0°. The viscous flow is examined in detail via surface and field velocity vectors, vorticity, density and pressure contours. For á = 12°, the unsteady DES solutions show a weak shock at the aft-wing trailing edge. Also, the flow near the joint exhibits a region of mild separation.

  5. It Started with George Ellery Hale

    NASA Astrophysics Data System (ADS)

    Parker, E. N.

    1999-05-01

    With his invention of the spectroheliograph, showing the structure and activity of the surface of the Sun, and with his spectroscopic determination of the magnetic character of the sunspot, Hale initiated a line of research that has brought us deeper into the mysteries of the Sun with each passing decade. The flare is perhaps the most spectacular aspect of the activity, along with the more recently discovered coronal mass ejection. However, we must not overlook the spectacular revelation, by Grotrian, Edlen, and Lyot, that the outer atmosphere of the Sun has a temperature of a million or more degrees K, providing both radio and X-ray emission. It is all too often forgotten in these heady times that, while we have a number of plausible ideas about how things work, there is not yet a clear understanding of why a late main sequence star should exhibit such effects. Magnetic fields generated by some form of MHD dynamo appear to initiate the suprathermal activity in all its many forms. The intensely fibril form of the magnetic fields seems to be a clue to the nature of the dynamo process, and the first observational priority now is to develop a 4m telescope with an adaptive optics system that can properly resolve the individual fibrils at the visible surface (0.1" or better)to determine their behavior. Indeed the nature of the sunspot, the faculae and plages,the microflare, etc. all lie at the limits of telescopic resolution. The varying brightness of the Sun seems to be a byproduct of the magnetic activity, and besides the consequences for the climate at Earth, provides another baffling clue to the puzzle. We cannot guess what further marvels will be discovered before the puzzle is resolved in hard scientific terms, but we may be certain that Hale would have been enchanted, and probably leading the charge, were he alive today.

  6. Flexural strength and fatigue of steel fiber reinforced concrete (2004 Hale Boggs deck).

    DOT National Transportation Integrated Search

    2008-12-01

    Through its history, a variety of wearing surface systems for the orthotropic steel deck of the Luling Bridge (aka Hale Boggs : Bridge) have been built and studied. The main problem with these systems was they did not last the expected service life (...

  7. Twisting and Writhing with George Ellery Hale

    NASA Astrophysics Data System (ADS)

    Canfield, Richard C.

    2013-06-01

    Early in his productive career in astronomy, George Ellery Hale developed innovative solar instrumentation that allowed him to make narrow-band images. Among the solar phenomena he discovered were sunspot vortices, which he attributed to storms akin to cyclones in our own atmosphere. Using the concept of magnetic helicity, physicists and mathematicians describe the topology of magnetic fields, including twisting and writhing. Our contemporary understanding of Hale's vortices as a consequence of large-scale twist in sunspot magnetic fields hinges on a key property of helicity: conservation. I will describe the critical role that this property plays, when applied to twist and writhe, in a fundamental aspect of global solar magnetism: the hemispheric and solar cycle dependences of active region electric currents with respect to magnetic fields. With the advent of unbroken sequences of high-resolution magnetic images, such as those presently available from the Helioseismic and Magnetic Imager on Solar Dynamics Observatory, the flux of magnetic helicity through the photosphere can be observed quantitatively. As magnetic flux tubes buoy up through the convection zone, buffeted and shredded by turbulence, they break up into fragments by repeated random bifurcation. We track these rising flux fragments in the photosphere, and calculate the flux of energy and magnetic helicity there. Using a quantitative model of coronal currents, we also track connections between these fragments to calculate the energy and magnetic helicity stored at topological interfaces that are in some ways analogous to the storage of stress at faults in the Earth's crust. Comparison of these values to solar flares and interplanetary coronal mass ejections implies that this is the primary storage mechanism for energy and magnetic helicity released in those phenomena, and suggests a useful tool for quantitative prediction of geomagnetic storms.

  8. Using carrier-depletion silicon modulators for optical power monitoring.

    PubMed

    Yu, Hui; Korn, Dietmar; Pantouvaki, Marianna; Van Campenhout, Joris; Komorowska, Katarzyna; Verheyen, Peter; Lepage, Guy; Absil, Philippe; Hillerkuss, David; Alloatti, Luca; Leuthold, Juerg; Baets, Roel; Bogaerts, Wim

    2012-11-15

    Defect-mediated subbandgap absorption is observed in ion-implanted silicon-on-oxide waveguides that experience a rapid thermal annealing at 1075°C. With this effect, general carrier-depletion silicon modulators exhibit the capability of optical power monitoring. Responsivity is measured to be 22 mA/W for a 3 mm long Mach-Zehnder modulator of 2×10(18) cm(-3) doping concentration at -7.1 V bias voltage and 5.9 mA/W for a ring modulator of 1×10(18) cm(-3) doping concentration at -10 V bias voltage. The former is used to demonstrate data detection of up to 35 Gbits/s.

  9. Chemistry in the Dusty Coma of Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Boice, D. C.; Cochran, A. L.; Disanti, M. A.; Huebner, W. F.

    1998-09-01

    Recent progress on a multifluid, hydrodynamic model is presented for the dusty gas flow in the inner coma of comet Hale-Bopp at several heliocentric distances. The simulations are based on a 1-D neutral coma model with detailed photo and gas-phase chemistry and dust entrainment by the gas, a separate energy balance for the electrons, separate flow of the neutral gas, fast neutral atomic and molecular hydrogen, and dust entrainment with fragmentation. The model accounts for three sources of gas release: sublimation from surface ices, transport of gas from subsurface regions through the surface, and release of gas from dust in the coma. This permits a consistent study of the importance and strength of each possible source for a variety of gas-phase species. The simulations allow a study of the changes with heliocentric distance of features within a cometary coma, e.g., spatial distributions of gas-phase species and dust of various sizes and the velocity and temperature profiles. In particular, the model is used to probe spatial distributions of gas-phase species (e.g., CN, CH, C_3, C_2, HCN, HNC, CO) and dust, and the velocity and temperature structure to understand the complex gas-phase chemistry that occurs in the inner coma. Comparisons with observations are made where available to characterize the environment surrounding comet Hale-Bopp and to aid in assimilating a variety of diverse observations of this unique comet.

  10. Geology and ground-water resources of Hale County, Texas

    USGS Publications Warehouse

    Cronin, J.G.; Wells, Lloyd C.

    1963-01-01

    It is estimated that in 1955 about 39 million acre-feet of water was in storage in the Ogallala formation in Hale County; however, only about 16 million is theoretically available to wells, and a somewhat smaller amount is practically available. About 3 million acre-feet was removed from storage during 1938-55. Water levels in wells have declined more or less steadily since 1938, and it is apparent that the ground-water resources of the county are insufficient to support large-scale perennial irrigation such as that of 1955.

  11. Hco+ in the Coma of Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Lovell, A. J.; Schloerb, F. P.; Bergin, E. A.; Dickens, J. E.; De Vries, C. H.; Senay, M. C.; Irvine, W. M.

    1997-05-01

    Maps of comet C/1995 O1 (Hale-Bopp) in the millimeter-wave emission of the ion HCO^+ revealed a local minimum near the nucleus position, with a maximum about 100,000 km in the antisolar direction. These observed features of the HCO^+ emission require a low abundance of HCO^+ due to enhanced destruction in the inner coma of the comet, within a region of low electron temperature (T_e). To set constraints on the formation of HCO^+ in the coma, as well as the location and magnitude of the transition to higher T_e, the data are compared with the results of ion-molecule chemistry models.

  12. HCO+ in the coma of comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Lovell, A. J.; Schloerb, F. P.; Bergin, E. A.; Dickens, J. E.; Devries, C. H.; Senay, M. C.; Irvine, W. M.; Ferris, J. P. (Principal Investigator)

    1997-01-01

    Maps of comet C/1995 O1 (Hale-Bopp) in the millimeter-wave emission of the ion HCO+ revealed a local minimum near the nucleus position, with a maximum about 100,000 km in the antisolar direction. These observed features of the HCO+ emission require a low abundance of HCO+ due to enhanced destruction in the inner coma of the comet, within a region of low electron temperature (Te). To set constraints on the formation of HCO+ in the coma, as well as the location and magnitude of the transition to higher Te, the data are compared with the results of ion-molecule chemistry models.

  13. Sources of Gullies in Hale Crater

    NASA Image and Video Library

    2017-04-12

    Color from the High Resolution Imaging Science Experiment (HiRISE) instrument onboard NASA's Mars Reconnaissance Orbiter can show mineralogical differences due to the near-infrared filter. The sources of channels on the north rim of Hale Crater show fresh blue, green, purple and light toned exposures under the the overlying reddish dust. The causes and timing of activity in channels and gullies on Mars remains an active area of research. Geologists infer the timing of different events based on what are called "superposition relationships" between different landforms. Areas like this are a puzzle. The map is projected here at a scale of 25 centimeters (9.8 inches) per pixel. [The original image scale is 25.2 centimeters (9.9 inches) per pixel (with 1 x 1 binning); objects on the order of 76 centimeters (29.9 inches) across are resolved.] North is up. https://photojournal.jpl.nasa.gov/catalog/PIA21586

  14. ‘Imi Hale – The Native Hawaiian Cancer Awareness, Research, and Training Network: Second-Year Status Report

    PubMed Central

    Braun, Kathryn L.; Tsark, JoAnn; Ann Santos, Lorrie; Abrigo, Lehua

    2010-01-01

    Purpose The purpose of this paper is to describe ‘Imi Hale, a program developed and managed by Native Hawaiians to increase cancer awareness and research capacity among Native Hawaiians. This US subgroup of indigenous people of the Hawaiian islands has disproportionately high rates of cancer mortality and low rates of participation in health and research careers. Methods As a community-based research project, ‘Imi Hale spent its first year gathering data from Native Hawaiians about their cancer awareness and research priorities. These findings guide ‘Imi Hale’s community and scientific advisors, a community-based Institutional Review Board, Na Liko Noelo (budding researchers), and staff in developing and carrying out projects that address these priority areas. Emphasis is placed on transferring skills and resources to Native Hawaiians through training, technical assistance, and mentorship. A biennial survey assesses the extent to which community-based participatory research principles are being followed. Principal Findings By the end of the second year, statewide and island-specific awareness plans were produced, and 9 funded awareness projects are supporting the development and dissemination of Hawaiian health education materials. Research accomplishments include the enrollment of 42 Native Hawaiian Na Liko Noelo (budding researchers), 22 of which are involved in 14 funded research projects. The biennial evaluation survey found that 92% of our advisors felt that ‘Imi Hale was promoting scientifically rigorous research that was culturally appropriate and respectful of Native Hawaiian beliefs, and 96% felt that ‘Imi Hale was following its own principles of community-based participatory research. Conclusion ‘Imi Hale’s community-based approach to promoting cancer awareness will result in a sustainable infrastructure for reducing the cancer burden on Native Hawaiians. PMID:15352771

  15. A two-step method for developing a control rod program for boiling water reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taner, M.S.; Levine, S.H.; Hsiao, M.Y.

    1992-01-01

    This paper reports on a two-step method that is established for the generation of a long-term control rod program for boiling water reactors (BWRs). The new method assumes a time-variant target power distribution in core depletion. In the new method, the BWR control rod programming is divided into two steps. In step 1, a sequence of optimal, exposure-dependent Haling power distribution profiles is generated, utilizing the spectral shift concept. In step 2, a set of exposure-dependent control rod patterns is developed by using the Haling profiles generated at step 1 as a target. The new method is implemented in amore » computer program named OCTOPUS. The optimization procedure of OCTOPUS is based on the method of approximation programming, in which the SIMULATE-E code is used to determine the nucleonics characteristics of the reactor core state. In a test in cycle length over a time-invariant, target Haling power distribution case because of a moderate application of spectral shift. No thermal limits of the core were violated. The gain in cycle length could be increased further by broadening the extent of the spetral shift.« less

  16. Multispectral study of CO production from C/1995 O1 (Hale-Bopp)

    NASA Astrophysics Data System (ADS)

    Harris, W. M.; Nordsieck, K. H.; Scherb, F.; Mierkiwicz, E. J.; Morgenthaler, J. P.; Oliversen, R. J.

    1998-09-01

    A series of unique observartions of CO and its daughter products that were obtained simultaneously as part of the University of Wisconsin/Goddard Space Flight Center Hale-Bopp campaign are presented. CO is the second most abundant volatile species in the coma of comets, one that actually dominates production at large heliocentric distances, however its photchemical evolution is poorly understood due to the lack of good emission line tracers in the visible. On 8 April, 1997, we obtained wide field simultaneous observations of CI (1657 Angstroms) intensity and polarization from a sounding rocket, OI (6300 Angstroms) emission using the Wisconsin Hα Mapper (WHaM) facility, and measurements using the McMath-Pierce Solar telescope of CI (9850 Angstroms) emission at different points in the inner coma. Combined, these data contain information on the radial distribution, source function, equilibrium structure, photochemical lifetime of CO, and the outflow speed of its C and O daughter products. Combined, these results suggest rapid dissociation of CO in the collisionally thick inner coma of Hale-Bopp, followed by a high velocity outflow of the daughter products. Both results suggest some discrepancies with expectations, and we discuss their implications.

  17. Sarah J. Hale High School Project BEAM-UP, 1985-86. OEA Evaluation Report.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.

    Project BEAM-UP offers English as a second language (ESL), native language arts, and bilingual content-area instruction to students of limited English proficiency (LEP) in grades 9 through 12 at Sarah J. Hale High School in Brooklyn, New York. The student participants speak Spanish or Haitian Creole. The goal of the program is to help these…

  18. Natural convection in the Hale-Shaw cell of horizontal Bridgman solidification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Y.; Liu, J.; Zhou, Y.

    1995-08-01

    The numerical simulation of natural convection in the Hale-Shaw cell during horizontal Bridgman solidification reveals that the convection is present even for the very thin cell. The effects of the horizontal temperature gradient, G, thickness of the cell, H, temperature difference between the top and bottom of the cell, and other parameters have been studied. These findings have been confirmed by experiments through direct observation and measurement of convection in the cell containing succinonitrile transparent model alloy.

  19. Essayists, essays, and hosts: Daniel Hale Williams Medical Reading Club.

    PubMed Central

    Greene Reed, T.; Evans, C. C.

    1996-01-01

    The 66-year-old Daniel Hale Williams Medical Reading Club is an independent reading club comprised of 65 physicians in the metropolitan Washington, DC, area. Members representing all specialty fields meet six times a year for dinner and fellowship, to consider topics of common interest to the profession, and to hear a prepared lecture given by a featured essayist. Club members take turns as hosts for each meeting. This article gives a historical list of these meetings, naming the essayist and the topic, the hosts, and the site of the meetings. PMID:8918074

  20. Sarah J. Hale High School, Project BECOME. O.E.E. Evaluation Report, 1982-1983.

    ERIC Educational Resources Information Center

    Bulkin, Elly; Sica, Michael

    Project BECOME, a mainstreaming program for Hispanic and Haitian students of limited English proficiency, provided instruction in ESL and native language studies, as well as bilingual instruction in social studies, mathematics, science, and typing. The program, which was implemented at Sarah J. Hale High School (located in downtown Brooklyn, New…

  1. Neutral Atomic Emissions from Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Oliversen, R. J.; Scherb, F.; Roesler, F. L.; Mierkiewicz, E. J.; Woodward, R. C.; Hilton, G. M.; Doane, N. E.

    1997-07-01

    High resolution (R=100,000) spectra of atomic oxygen, hydrogen, and carbon from Comet Hale-Bopp were obtained at the NSO McMath-Pierce main telescope from February 8 to April 19, 1997, using a 50 mm dual-etalon Fabry-Perot/CCD spectrometer. The field of view was 6 arcmin. Spectra with good signal-to-noise were obtained for the emission lines [O I] 6300 Angstroms, Hα (6563 Angstroms), and [C I] 9850 Angstroms. On several of these nights, complementary [O I] 6300 Angstroms observations were simultaneously obtained with the Wisconsin Hα Mapper (WHα M) at Kitt Peak. Additional [O I] 6300 Angstroms observations were also obtained in September 1996. These [C I] 9850 Angstroms observations are the first extensive data set of this cometary line. We will present an overview of our observations and preliminary results.

  2. Solar-powered unmanned aerial vehicles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reinhardt, K.C.; Lamp, T.R.; Geis, J.W.

    1996-12-31

    An analysis was performed to determine the impact of various power system components and mission requirements on the size of solar-powered high altitude long endurance (HALE)-type aircraft. The HALE unmanned aerial vehicle (UAV) has good potential for use in many military and civil applications. The primary power system components considered in this study were photovoltaic (PV) modules for power generation and regenerative fuel cells for energy storage. The impact of relevant component performance on UAV size and capability were considered; including PV module efficiency and mass, power electronics efficiency, and fuel cell specific energy. Mission parameters such as time ofmore » year, flight altitude, flight latitude, and payload mass and power were also varied to determine impact on UAV size. The aircraft analysis method used determines the required aircraft wing aspect ratio, wing area, and total mass based on maximum endurance or minimum required power calculations. The results indicate that the capacity of the energy storage system employed, fuel cells in this analysis, greatly impacts aircraft size, whereas the impact of PV module efficiency and mass is much less important. It was concluded that an energy storage specific energy (total system) of 250--500 Whr/kg is required to enable most useful missions, and that PV cells with efficiencies greater than {approximately} 12% are suitable for use.« less

  3. An Integrated Modeling Study for Coordinated Observations of H, O, OH, and H2O(+) Emissions in the Coma and Ion Tail of the Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Smyth, William H.

    2001-01-01

    This project has two overall objectives. One objective is to advance our general understanding of both the comet neutral atmosphere and the cometary plasma in the atmosphere and ion tall. The other objective is to obtain specific key information about comet Hale-Bopp that is generally important for Hale-Bopp studies. The primary emphasis in this project is to analyze, in a self-consistent manner, excellent quality high resolution image and line profile observations obtained by the University of Wisconsin for H, O, OH, and H2O+ emissions from the inner coma, outer coma, and ion tail of Hale-Bopp. The information on the spatial and velocity distributions of H2O neutral and ionized photo-products in the inner coma, outer coma, and in the H2O+ ion tail is of substantial and direct importance in the development of an integrated understanding of the complex structure and dynamics of the neutral and plasma species in the atmosphere of Hale-Bopp in particular and comets in general. The H2O production rate of Hale-Bopp is determined and, together with the other information related to the structure and dynamics of the neutral and plasma atmospheres obtained in this study, provide critical information important for a wide variety of research conducted by other groups.

  4. Aaron Douglas and Hale Woodruff: African American Art Education, Gallery Work, and Expanded Pedagogy

    ERIC Educational Resources Information Center

    Bey, Sharif

    2011-01-01

    This analysis of archival materials discovered at Fisk and Atlanta Universities examines the teaching careers of Aaron Douglas and Hale Woodruff, two African American artists who came to prominence during the New Negro Movement in the 1920s and taught at historically Black universities in the 1930s and 1940s. These artists had a profound influence…

  5. Sarah J. Hale High School. Project BECOME. O.E.E. Evaluation Report, 1981-1982.

    ERIC Educational Resources Information Center

    Torres, Judith A.; And Others

    Project BECOME at Sarah J. Hale High School in Brooklyn, New York, was designed to provide instruction in English as a second language and in native language arts, as well as bilingual instruction in social studies, mathematics, and science, for Hispanic and Haitian high school students of limited English proficiency. In 1981-82, the second year…

  6. Deplete! Deplete! Deplete!

    NASA Astrophysics Data System (ADS)

    Woodson, J.

    2017-12-01

    Deplete is intended to demonstrate by analogy the harmful effect that Green House Gases (GHG's) such as CO2 and H2O vapor are causing to the Ozone Layer. Increasing temperatures from human activities are contributing to the depletion of Ozone.

  7. Activity of Comet Hale-Bopp (1995 01) Beyond 6 AU From the Sun

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.

    1996-01-01

    The physical evolution of comet Hale-Bopp is investigated along the preperihelic arc of its orbit at heliocentric distances larger than 6 AU. The comet's considerable intrinsic brightness and activity are explained by the existence of a relatively larg area on its nucleus surface that is a resevoir of both carbon monoxide and dust particulates. Three recuring dust emission events observed in August-October 1995 are studied in some detail.

  8. Flexural strength and fatigue of steel fiber reinforced concrete (SFRC) (2004 Hale Boggs Deck) : technical summary report.

    DOT National Transportation Integrated Search

    2009-12-01

    The Luling Bridge (Hale Boggs Memorial Bridge) traverses the Mississippi River in St. Charles : Parish, Louisiana. It was one of the first cable-stayed bridges in the United States and opened to : traffic in 1983. Unique to its design are relatively ...

  9. Coordinated Observations of Comet Hale-Bopp between 32 and 860 GHz

    NASA Astrophysics Data System (ADS)

    Bieging, J. H.; Mauersberger, R.; Altenhoff, W. J.; Haslam, C. G. T.; Kreysa, E.; Schmidt, J.; Schraml, J. B.; Stumpff, P.; von Kap-Herr, A.; Butler, B.; McMullin, J.; Butner, H. M.; Martin, R. N.; Muders, D.; Peters, W. L.; Sievers, A.; Thum, C.; Wink, J.; Zylka, R.

    1997-12-01

    The concept of simultaneous multifrequency continuum observations, successfully tested on Comet Hyakutake, was applied to Comet Hale-Bopp, using the Heinrich Hertz Submillimeter Telescope (HHT) with the four color bolometer between 250 and 870 GHz; the IRAM 30m telescope at 250 GHz; the IRAM Plateau de Bure Interferometer near 90 and 240 GHz; and the MPIfR 100m telescope at 32 GHz. Near-simultaneous measurements were done between 1997 February 15 and 1997 April 26, mainly concentrated in mid-March shortly before perigee of the comet. The measurements gave the following preliminary results: (a) interferometer detection of the nuclear continuum emission. The derived mean diameter is of the order of 50 km. (b) a radio halo with a gaussian HPW of ~ 11 arcsec , corresponding to a diameter of 11000 km at geocentric distance of 1.2 A.U. (c) a spectral index (SI) of ~ 3.0 of the total signal, indicating a particle size distribution in the radio halo between 0.1 and 3 mm. Assuming an average cometary density of 0.5 g cm(-3) , the mass contained in the nucleus is about 3x 10(19) g and 10(12) g in the particle halo, inferred from the SI. A more detailed analysis is under way, which includes corrections for the various calibration scales at the different telescopes and the possible contamination of the observed bolometer signal by molecular line emission. We will report on the results of this analysis and the implications for the mm -- submm wavelength radio spectrum of Comet Hale-Bopp.

  10. Autumn Afternoon in Hale Crater

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The seasons on Mars and Earth are anti-correlated at present: days are getting shorter and shadows are getting longer as autumn end sand the beginning of winter draws nearer in the martian southern hemisphere, just as the same is occurring in Earth's northern hemisphere. Long shadows are especially prominent in this high resolution view of mountains forming part of the central peaks of Hale Crater (left), a 136 kilometer-(85 mile)-diameter impact crater at 36oS, 37oW. The two pictures were taken simultaneously by the Mars Global Surveyor Mars Orbiter Camera on November 10, 2000. The sun illuminates the scene from the northwest (upper left)about 22o above the horizon. Knowing the sun angle and the length of the longest shadow (1.6 km; 1.0 mi), the height of the largest peak in the high resolution view (right) is about 630 meters (2,070 ft) above the crater floor. Sand dunes blanket the middle portion of the high resolution view, and small gullies--possibly carved by water--can be seen on the slopes of some of the peaks at the upper left. Winter in the southern hemisphere will begin in mid-December 2000. The high resolution view covers an area 3 km (1.9 mi) wide at a full-resolution scale of 3 meters (9.8 ft) per pixel.

  11. Feeling depleted and powerless: the construal-level mechanism.

    PubMed

    Kim, Junha; Lee, Sujin; Rua, Tuvana

    2015-04-01

    Individuals exercise self-control daily to achieve desired goals; at the same time, people engage in social interaction daily and influence (feel powerful) or are influenced (feel powerless) by others. Does controlling the self have an unforeseen consequence for people's perception of their capacity to control others? Five studies-one correlational and four experimental-demonstrate that ego depletion from prior self-control determines one's personal sense of power; low-level, concrete mental construals account for this relationship. Our results showed that people with higher trait self-control reported a greater sense of power (Study 1). People who had depleted their self-control-related regulatory resources (vs. those who had not) experienced a lower sense of power (Study 2). The relationship between ego depletion and low sense of power was mediated by construal level (Study 3) and observed only when low-level, concrete construals were present, but not under high-level, abstract construals (Studies 4 and 5). © 2015 by the Society for Personality and Social Psychology, Inc.

  12. The Detection of Water Ice in Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Davies, John K.; Roush, Ted L.; Cruikshank, Dale P.; Bartholomew, Mary Jane; Geballe, Thomas R.; Owen, Tobias

    1996-01-01

    We present spectra of Comet Hale-Bopp (C/1995 01) covering the range 1.4-2.5 micron that were recorded when the comet was 7 AU from the Sun. These show I)road absorption features at 1.5 and 2.05 micron. We show that some, but not all, of this absorption could be matched by an intimate mixture of water ice and a low albedo material such as carbon on the nucleus. However, we recognize that it is more likely that the ice features are produced by scattering from icy grains in the coma. The absence of absorption at 1.65 micron suggests that this ice is probably in the amorphous state. An unidentified additional component may be required to account for the downward slope at the longwavelength end of the spectrum.

  13. Haser Scalelengths for Comet Hale--Bopp (1995 O1) Between 3.5 to 0.92 AU

    NASA Astrophysics Data System (ADS)

    Baugh, N. F.; Schleicher, D. G.

    2003-05-01

    During a four-year interval, more than 90 nights of narrowband photometry were obtained of Comet Hale--Bopp (1995 O1) from the Lowell and Perth Observatories. Because these observations cover an extremely large range of heliocentric distances (r), the variation of gas production rates with r can be used to probe each species' release from the nucleus as a function of solar illumination and temperature. Unfortunately, Hale-Bopp's very high total gas production when it was closer than about 2-3 AU from the Sun resulted in unusually high gas outflow velocities as compared to other comets. Therefore, canonical scalelengths do not adequately reproduce the spatial distribution of the observed gas species, OH, NH, CN, C2, and C3, at small r. Based on narrowband images obtained at perihelion, Schleicher et al. (1999, BAAS 31, 1128) determined that most species' parent and daughter Haser scalelengths needed to be increased by 2-3x the canonical values to reproduce the bulk radial fall-off for each gas species, yielding perihelion production rates 1.1-3.6x larger than otherwise calculated, with water exhibiting the largest correction. So that the entire Lowell/Perth dataset can be reduced to absolute production rates, we have now begun an effort to determine appropriate scalelengths for Hale-Bopp between about 3.5 AU and perihelion, which can be combined with the recently reported results from modeling spatial profiles beyond 2.8 AU by Rauer et al. (2003, A&A 397, 1109-1122). We anticipate reporting on preliminary findings of this investigation, including scalelengths and r-dependencies which can be used to accurately extrapolate aperture photometry measurements to total coma abundances, as well as resulting absolute gas production rates. This research is supported by NASA and the NSF REU program.

  14. Nuclide Depletion Capabilities in the Shift Monte Carlo Code

    DOE PAGES

    Davidson, Gregory G.; Pandya, Tara M.; Johnson, Seth R.; ...

    2017-12-21

    A new depletion capability has been developed in the Exnihilo radiation transport code suite. This capability enables massively parallel domain-decomposed coupling between the Shift continuous-energy Monte Carlo solver and the nuclide depletion solvers in ORIGEN to perform high-performance Monte Carlo depletion calculations. This paper describes this new depletion capability and discusses its various features, including a multi-level parallel decomposition, high-order transport-depletion coupling, and energy-integrated power renormalization. Several test problems are presented to validate the new capability against other Monte Carlo depletion codes, and the parallel performance of the new capability is analyzed.

  15. History of Solar Magnetic Fields Since George Ellery Hale

    NASA Astrophysics Data System (ADS)

    Stenflo, J. O.

    2017-09-01

    As my own work on the Sun's magnetic field started exactly 50 years ago at Crimea in the USSR, I have been a participant in the field during nearly half the time span since Hale's discovery in 1908 of magnetic fields in sunspots. The present historical account is accompanied by photos from my personal slide collection, which show a number of the leading personalities who advanced the field in different areas: measurement techniques, from photographic to photoelectric and imaging methods in spectro-polarimetry; theoretical foundations of MHD and the origin of cosmic magnetic fields (birth of dynamo theory); the quest for increased angular resolution from national projects to international consortia (for instruments both on ground and in space); introduction of the Hanle effect in astrophysics and the Second Solar Spectrum as its playground; small-scale nature of the field, the fundamental resolution limit, and transcending it by resolution-independent diagnostics.

  16. Hubble Images of Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This is a series of Hubble Space Telescope observations of the region around the nucleus of Hale-Bopp, taken on eight different dates since September 1995. They chronicle changes in the evolution of the nucleus as it moves ever closer to, and is warmed by, the sun.

    The first picture in the sequence, seen at upper left shows a strong dust outburst on the comet that occurred when it was beyond the orbit of Jupiter. Images in the Fall of 1996 show multiple jets that are presumably connected to the activation of multiple vents on the surface of the nucleus.

    In these false color images, taken with the Wide Field and Planetary Camera 2, the faintest regions are black, the brightest regions are white, and intermediate intensities are represented by different levels of red. All images are processed at the same spatial scale of 280 miles per pixel (470 kilometers), so the solid nucleus, no larger than 25 miles across, is far below Hubble's resolution.

    The Wide Field/Planetary Camera 2 was developed by the Jet Propulsion Laboratory and managed by the Goddard Spaced Flight Center for NASA's Office of Space Science.

    This image and other images and data received from the Hubble Space Telescope are posted on the World Wide Web on the Space Telescope Science Institute home page at URL http://oposite.stsci.edu/pubinfo/

  17. Functional Requirements Document for HALE UAS Operations in the NAS: Step 1. Version 3

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The purpose of this Functional Requirements Document (FRD) is to compile the functional requirements needed to achieve the Access 5 Vision of "operating High Altitude, Long Endurance (HALE) Unmanned Aircraft Systems (UAS) routinely, safely, and reliably in the national airspace system (NAS)" for Step 1. These functional requirements could support the development of a minimum set of policies, procedures and standards by the Federal Aviation Administration (FAA) and various standards organizations. It is envisioned that this comprehensive body of work will enable the FAA to establish and approve regulations to govern safe operation of UAS in the NAS on a routine or daily "file and fly" basis. The approach used to derive the functional requirements found within this FRD was to decompose the operational requirements and objectives identified within the Access 5 Concept of Operations (CONOPS) into the functions needed to routinely and safely operate a HALE UAS in the NAS. As a result, four major functional areas evolved to enable routine and safe UAS operations for an on-demand basis in the NAS. These four major functions are: Aviate, Navigate, Communicate, and Avoid Hazards. All of the functional requirements within this document can be directly traceable to one of these four major functions. Some functions, however, are traceable to several, or even all, of these four major functions. These cross-cutting functional requirements support the "Command / Control: function as well as the "Manage Contingencies" function. The requirements associated to these high-level functions and all of their supporting low-level functions are addressed in subsequent sections of this document.

  18. The Gas Production Rate and Coma Structure of Comet C/1995 O1 (Hale-Bopp)

    NASA Astrophysics Data System (ADS)

    Morgenthaler, Jeffrey P.; Harris, Walter M.; Roesler, Frederick L.; Scherb, Frank; Anderson, Christopher M.; Doane, Nathaniel E.; Oliversen, Ronald J.

    2002-06-01

    The University of Wisconsin-Madison and NASA-Goddard conducted acomprehensive multi-wavelength observing campaign of coma emissionsfrom comet Hale-Bopp, including OH 3080 Å, [O I] 6300 Å H2O+ 6158 Å, H Balmer-α 6563 Å, NH2 6330 Å, [C I] 9850 ÅCN 3879 Å, C2 5141 Å, C3 4062 Å,C I 1657 Å, and the UV and optical continua. In thiswork, we concentrate on the results of the H2O daughter studies.Our wide-field OH 3080 Å measured flux agrees with other, similarobservations and the expected value calculated from published waterproduction rates using standard H2O and OH photochemistry.However, the total [O I] 6300 Å flux determined spectroscopically overa similar field-of-view was a factor of 3-4 higher than expected.Narrow-band [O I] images show this excess came from beyond theH2O scale length, suggesting either a previously unknown source of[O I] or an error in the standard OH + ν→ O(1 D) + H branching ratio. The Hale-Bopp OH and[O I] distributions, both of which were imaged tocometocentric distances >1 × 106 km, were more spatiallyextended than those of comet Halley (after correcting for brightnessdifferences), suggesting a higher bulk outflow velocity. Evidence ofthe driving mechanism for this outflow is found in the Hα lineprofile, which was narrower than in comet Halley (though likelybecause of opacity effects, not as narrow as predicted by Monte-Carlomodels). This is consistent with greater collisional coupling betweenthe suprathermal H photodissociation products and Hale-Bopp's densecoma. Presumably because of mass loading of the solar wind by ionsand ions by the neutrals, the measured acceleration of H2O+ downthe ion tail was much smaller than in comet Halley. Tailwardextensions in the azimuthal distributions of OH 3080 Å,[O I], and [C I] , as well as a Doppler asymmetry in the[O I] line profile, suggest ion-neutral coupling. While thetailward extension in the OH can be explained by increased neutralacceleration, the [O I] 6300 Å and [C I] 9850

  19. The Gas Production Rate and Coma Structure of Comet C/1995 01 (Hale-Bopp)

    NASA Technical Reports Server (NTRS)

    Morgenthaler, Jeffrey P.; Harris, Walter M.; Roesler, Frederick L.; Scherb, Frank; Anderson, Christopher M.; Doane, Nathaniel E.; Oliversen, Ronald J.

    2002-01-01

    The University of Wisconsin-Madison and NASA-Goddard conducted a comprehensive multi-wavelength observing campaign of coma emissions from comet Hale-Bopp, including OH 3080 A, [O I] 6300 A, H2O(+) 6158 A, H Balmer-alpha 6563 A, NH2 6330 A, [C I] 9850 A CN 3879 A, C2 5141 A, C3 4062 A, C I 1657 A, and the UV and optical continua. In this work, we concentrate on the results of the H2O daughter studies. Our wide-field OH 3080 A measured flux agrees with other, similar observations and the expected value calculated from published water production rates using standard H2O and OH photochemistry. However, the total [O I] 6300 A flux determined spectroscopically over a similar field-of-view was a factor of 3 - 4 higher than expected. Narrow-band [O I] images show this excess came from beyond the H2O scale length, suggesting either a previously unknown source of [O I] or an error in the standard OH + upsilon to O((sup I)D) + H branching ratio. The Hale-Bopp OH and [O I] distributions, both of which were imaged to cometocentric distances greater than 1 x 10(exp 6) km, were more spatially extended than those of comet Halley (after correcting for brightness differences), suggesting a higher bulk outflow velocity. Evidence of the driving mechanism for this outflow is found in the H(alpha) line profile, which was narrower than in comet Halley (though likely because of opacity effects, not as narrow as predicted by Monte-Carlo models). This is consistent with greater collisional coupling between the suprathermal H photodissociation products and Hale-Bopp's dense coma. Presumably because of mass loading of the solar wind by ions and ions by the neutrals, the measured acceleration of H2O(+) down the ion tail was much smaller than in comet Halley. Tailward extensions in the azimuthal distributions of OH 3080 A, [O I], and [C I], as well as a Doppler asymmetry in the [O I] line profile, suggest ion-neutral coupling. While the tailward extension in the OH can be explained by increased

  20. Regenerative fuel cells for High Altitude Long Endurance Solar Powered Aircraft

    NASA Astrophysics Data System (ADS)

    Mitlitsky, F.; Colella, N. J.; Myers, B.; Anderson, C. J.

    1993-06-01

    High Altitude Long Endurance (HALE) unmanned missions appear to be feasible using a lightweight, high efficiency, span-loaded, Solar Powered Aircraft (SPA) which includes a Regenerative Fuel Cell (RFC) system and novel tankage for energy storage. An existing flightworthy electric powered flying wing design was modified to incorporate present and near-term technologies in energy storage, power electronics, aerodynamics, and guidance and control in order to substantiate feasibility. The design philosophy was to work with vendors to identify affordable near-term technological opportunities that could be applied to existing designs in order to reduce weight, increase reliability, and maintain adequate efficiency of components for delivery within 18 months. The energy storage subsystem for a HALE SPA is a key driver for the entire vehicle because it can represent up to half of the vehicle weight and most missions of interest require the specific energy to be considerably higher than 200 W-hr/kg for many cycles. This stringent specific energy requirement precludes the use of rechargeable batteries or flywheels and suggests examination of various RFC designs. An RFC system using lightweight tankage, a single fuel cell (FC) stack, and a single electrolyzer (EC) stack separated by the length of a spar segment (up to 39 ft), has specific energy of approximately 300 W-hr/kg with 45% efficiency, which is adequate for HALE SPA requirements. However, this design has complexity and weight penalties associated with thermal management, electrical wiring, plumbing, and structural weight. A more elegant solution is to use unitized RFC stacks (reversible stacks that act as both FC's and EC's) because these systems have superior specific energy, scale to smaller systems more favorably, and have intrinsically simpler thermal management.

  1. Disability-Adjusted Life-Years (DALYs) for 315 Diseases and Injuries and Healthy Life Expectancy (HALE) in Iran and its Neighboring Countries, 1990-2015: Findings from Global Burden of Disease Study 2015.

    PubMed

    Sepanlou, Sadaf G; Parsaeian, Mahboubeh; Krohn, Kristopher J; Afshin, Ashkan; Farzadfar, Farshad; Roshandel, Gholamreza; Karimkhani, Chante; Bazargan-Hejazi, Sharzad; Kiadaliri, Aliasghar Ahmad; Ahmadieh, Hamid; Djalalinia, Shirin; Ebrahimi, Hedyeh; Eshrati, Babak; Esteghamati, Ali Reza; Farvid, Maryam S; Fereshtehnejad, Seyed-Mohammad; Hafezi-Nejad, Nima; Hassanvand, Mohammad Sadegh; Heydarpour, Pouria; Islami, Farhad; Karimi, Seyed M; Katibeh, Marzieh; Khosravi, Ardeshir; Khubchandani, Jagdish; Mahdavi, Mahdi; Pishgar, Farhad; Qorbani, Mostafa; Rahimi-Movaghar, Vafa; Safi, Sare; Sahraian, Mohammad Ali; Shahraz, Saeid; Sheikhbahaei, Sara; Mohammadi, Alireza; Mokdad, Ali H; Vos, Theo; Murray, Christopher J L; Moradi-Lakeh, Maziar; Naghavi, Mohsen; Malekzadeh, Reza

    2017-07-01

    Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the progress of nations toward achievement of sustainable development goals. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) as main summary measures of health. We assessed the trends of health status in Iran and 15 neighboring countries using these summary measures. We used the results of GBD 2015 to present the levels and trends of DALYs, life expectancy (LE), and HALE in Iran and its 15 neighboring countries from 1990 to 2015. For each country, we assessed the ratio of observed levels of DALYs and HALE to those expected based on socio-demographic index (SDI), an indicator composed of measures of total fertility rate, income per capita, and average years of schooling. All-age numbers of DALYs reached over 19 million years in Iran in 2015. The all-age number of DALYs has remained stable during the past two decades in Iran, despite the decreasing trends in all-age and age-standardized rates. The all-cause DALY rates decreased from 47,200 in 1990 to 28,400 per 100,000 in 2015. The share of non-communicable diseases in DALYs increased in Iran (from 42% to 74%) and all of its neighbors between 1990 and 2015; the pattern of change is similar in almost all 16 countries. The DALY rates for NCDs and injuries in Iran were higher than global rates and the average rate in High Middle SDI countries, while those for communicable, maternal, neonatal, and nutritional disorders were much lower in Iran. Among men, cardiovascular diseases ranked first in all countries of the region except for Bahrain. Among women, they ranked first in 13 countries. Life expectancy and HALE show a consistent increase in all countries. Still, there are

  2. Hydrogen-powered flight

    NASA Technical Reports Server (NTRS)

    Smith, Timothy D.

    2005-01-01

    As the Nation moves towards a hydrogen economy the shape of aviation will change dramatically. To accommodate a switch to hydrogen the aircraft designs, propulsion, and power systems will look much different than the systems of today. Hydrogen will enable a number of new aircraft capabilities from high altitude long endurance remotely operated aircraft (HALE ROA) that will fly weeks to months without refueling to clean, zero emissions transport aircraft. Design and development of new hydrogen powered aircraft have a number of challenges which must be addressed before an operational system can become a reality. While the switch to hydrogen will be most outwardly noticeable in the aircraft designs of the future, other significant changes will be occurring in the environment. A switch to hydrogen for aircraft will completely eliminate harmful greenhouse gases such as carbon monoxide (CO), carbon dioxide (CO2), sulfur oxides (SOx), unburnt hydrocarbons and smoke. While these aircraft emissions are a small percentage of the amount produced on a daily basis, their placement in the upper atmosphere make them particularly harmful. Another troublesome gaseous emission from aircraft is nitrogen oxides (NOx) which contribute to ozone depletion in the upper atmosphere. Nitrogen oxide emissions are produced during the combustion process and are primarily a function of combustion temperature and residence time. The introduction of hydrogen to a gas turbine propulsion system will not eliminate NOx emissions; however the wide flammability range will make low NOx producing, lean burning systems feasible. A revolutionary approach to completely eliminating NOx would be to fly all electric aircraft powered by hydrogen air fuel cells. The fuel cells systems would only produce water, which could be captured on board or released in the lower altitudes. Currently fuel cell systems do not have sufficient energy densities for use in large aircraft, but the long term potential of eliminating

  3. Demonstration of Advanced Geophysics and Classification Methods on Munitions Response Sites - East Fork Valley Range Complex, Former Camp Hale

    DTIC Science & Technology

    2016-04-01

    with cores of igneous and metamorphic rocks flanked by steeply dipping sedimentary rocks . The valley floors range in elevation from about 9,310 to...Camp Hale, East Fork Valley Range Complex Munitions Response Site. This project is one in a series of projects funded by ESTCP to use advanced...Technology Certification Program ft Feet FUDS Formerly Used Defense Site GPS Global Positioning System ID Identification IMU Inertial Measurement Unit

  4. Animation of Site of Seasonal Flows in Hale Crater, Mars

    NASA Image and Video Library

    2015-09-28

    This frame from an animation simulates a fly-around look at one of the places on Mars where dark streaks advance down slopes during warm seasons, possibly involving liquid water. The streaks are roughly the length of a football field. The imaging and topographical information used in this false-color animation come from the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter. These dark features on the slopes are called "recurring slope lineae" or RSL. Planetary scientists using observations with the Compact Reconnaissance Imaging Spectrometer on the same orbiter detected hydrated salts on these slopes at Hale Crater, corroborating the hypothesis that the streaks are formed by briny liquid water. The image was produced by first creating a 3-D computer model (a digital terrain map) of the area based on stereo information from two HiRISE observations, and then draping a false-color image over the land-shape model. The vertical dimension is exaggerated by a factor of 1.5 compared to horizontal dimensions. http://photojournal.jpl.nasa.gov/catalog/PIA19919

  5. HALE UAS Command and Control Communications: Step 1 - Functional Requirements Document. Version 4.0

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The High Altitude Long Endurance (HALE) unmanned aircraft system (UAS) communicates with an off-board pilot-in-command in all flight phases via the C2 data link, making it a critical component for the UA to fly in the NAS safely and routinely. This is a new requirement in current FAA communications planning and monitoring processes. This document provides a set of comprehensive C2 communications functional requirements and performance guidelines to help facilitate the future FAA certification process for civil UAS to operate in the NAS. The objective of the guidelines is to provide the ability to validate the functional requirements and in future be used to develop performance-level requirements.

  6. Ego Depletion Does Not Interfere With Working Memory Performance.

    PubMed

    Singh, Ranjit K; Göritz, Anja S

    2018-01-01

    Ego depletion happens if exerting self-control reduces a person's capacity to subsequently control themselves. Previous research has suggested that ego depletion not only interferes with subsequent self-control but also with working memory. However, recent meta-analytical evidence casts doubt onto this. The present study tackles the question if ego depletion does interfere with working memory performance. We induced ego depletion in two ways: using an e-crossing task and using a Stroop task. We then measured working memory performance using the letter-number sequencing task. There was no evidence of ego depletion interfering with working memory performance. Several aspects of our study render this null finding highly robust. We had a large and heterogeneous sample of N = 1,385, which provided sufficient power. We deployed established depletion tasks from two task families (e-crossing task and Stroop), thus making it less likely that the null finding is due to a specific depletion paradigm. We derived several performance scores from the working memory task and ran different analyses to maximize the chances of finding an effect. Lastly, we controlled for two potential moderators, the implicit theories about willpower and dispositional self-control capacity, to ensure that a possible effect on working memory is not obscured by an interaction effect. In sum, this experiment strengthens the position that ego depletion works but does not affect working memory performance.

  7. Ego Depletion Does Not Interfere With Working Memory Performance

    PubMed Central

    Singh, Ranjit K.; Göritz, Anja S.

    2018-01-01

    Ego depletion happens if exerting self-control reduces a person’s capacity to subsequently control themselves. Previous research has suggested that ego depletion not only interferes with subsequent self-control but also with working memory. However, recent meta-analytical evidence casts doubt onto this. The present study tackles the question if ego depletion does interfere with working memory performance. We induced ego depletion in two ways: using an e-crossing task and using a Stroop task. We then measured working memory performance using the letter-number sequencing task. There was no evidence of ego depletion interfering with working memory performance. Several aspects of our study render this null finding highly robust. We had a large and heterogeneous sample of N = 1,385, which provided sufficient power. We deployed established depletion tasks from two task families (e-crossing task and Stroop), thus making it less likely that the null finding is due to a specific depletion paradigm. We derived several performance scores from the working memory task and ran different analyses to maximize the chances of finding an effect. Lastly, we controlled for two potential moderators, the implicit theories about willpower and dispositional self-control capacity, to ensure that a possible effect on working memory is not obscured by an interaction effect. In sum, this experiment strengthens the position that ego depletion works but does not affect working memory performance. PMID:29706923

  8. Electrophoretic analysis of cyanide depletion by Pseudomonas alcaligenes.

    PubMed

    Zaugg, S E; Davidson, R A; Walker, J C; Walker, E B

    1997-02-01

    Bacterial-facilitated depletion of cyanide is under development for remediation of heap leach operations in the gold mining industry. Capillary electrophoresis was found to be a powerful tool for quantifying cyanide depletion. Changes in cyanide concentration in aqueous suspensions of Pseudomonas alcaligenes bacteria and cyanide at elevated pH were easily monitored by capillary electrophoresis. The resulting data can be used to study rates of cyanide depletion by this strain of bacteria. Concentrations of these bacteria at 10(5) cells/mL were found to reduce cyanide from 100 ppm to less than 8 ppm in four days. In addition, other ions of interest in cyanide metabolism, such as formate, can be simultaneously analyzed. Direct UV detection of cyanide at 192 nm further simplifies the analytical method for these ions.

  9. Calculating Time-Integral Quantities in Depletion Calculations

    DOE PAGES

    Isotalo, Aarno

    2016-06-02

    A method referred to as tally nuclides is presented for accurately and efficiently calculating the time-step averages and integrals of any quantities that are weighted sums of atomic densities with constant weights during the step. The method allows all such quantities to be calculated simultaneously as a part of a single depletion solution with existing depletion algorithms. Some examples of the results that can be extracted include step-average atomic densities and macroscopic reaction rates, the total number of fissions during the step, and the amount of energy released during the step. Furthermore, the method should be applicable with several depletionmore » algorithms, and the integrals or averages should be calculated with an accuracy comparable to that reached by the selected algorithm for end-of-step atomic densities. The accuracy of the method is demonstrated in depletion calculations using the Chebyshev rational approximation method. Here, we demonstrate how the ability to calculate energy release in depletion calculations can be used to determine the accuracy of the normalization in a constant-power burnup calculation during the calculation without a need for a reference solution.« less

  10. Parametric investigations on the saturation intensity of Coumarin 102 for stimulated emission depletion application.

    PubMed

    Qin, H-Y; Zhao, W-X; Zhao, W; Zhang, C; Feng, X-Q; Liu, S-P; Wang, K-G

    2018-04-23

    Stimulated emission depletion (STED) microscopy performed using continuous-wave (CW) lasers has been investigated and developed by Willig et al. (Nature Methods, 2007, 4(11):915) for nearly a decade. Kuang et al. (Review of Scientific Instruments, 2010, 81:053709) developed the CW STED microscopy technique with 405 nm excitation and 532 nm depletion beams. In their research, Coumarin 102 dye was adopted and was found to be depletable. In this study, a parametric investigation of the depletion of Coumarin 102 dye is carried out experimentally. The influence of the excitation and depletion beam intensities and dye concentrations on the depletion efficiency are studied in detail. The results indicate the following: (1) The highest depletion occurs for the 100 μM Coumarin 102 solution, with a 1.4 μW excitation beam and a 115.3 mW depletion beam. (2) The minimum saturation intensity (Is) of STED, that is 13 MW cm -2 , is observed when the Coumarin 102 solution concentration is 10 μM. (3) Is values calculated directly from the depletion power derived with the cross-sectional area due to the full-width-at-half-maximum (FWHM) of the depletion beam show poor accuracy, where Is may be overestimated. Thus, a correction factor for the cross-sectional area is proposed. We also find that Is is not exactly constant for a fixed excitation beam power and dye concentration. This trend indicates that the conventional suppression function η(x)=e- ln (2)ISTED(x)/Is derived from picosecond STED may cause errors in evaluating the depletion process in CW STED microscopy. © 2018 The Authors Journal of Microscopy © 2018 Royal Microscopical Society.

  11. Neutral depletion and the helicon density limit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Magee, R. M.; Galante, M. E.; Carr, J. Jr.

    2013-12-15

    It is straightforward to create fully ionized plasmas with modest rf power in a helicon. It is difficult, however, to create plasmas with density >10{sup 20} m{sup −3}, because neutral depletion leads to a lack of fuel. In order to address this density limit, we present fast (1 MHz), time-resolved measurements of the neutral density at and downstream from the rf antenna in krypton helicon plasmas. At the start of the discharge, the neutral density underneath the antenna is reduced to 1% of its initial value in 15 μs. The ionization rate inferred from these data implies that the electronmore » temperature near the antenna is much higher than the electron temperature measured downstream. Neutral density measurements made downstream from the antenna show much slower depletion, requiring 14 ms to decrease by a factor of 1/e. Furthermore, the downstream depletion appears to be due to neutral pumping rather than ionization.« less

  12. Silicate Mineralogy of the Dust in the Inner Coma of Comet C/1995 01 (Hale-Bopp) Pre- and Post-Perihelion

    NASA Technical Reports Server (NTRS)

    Wooden, Diane H.; Harker, David E.; Woodward, Charles E.; Butner, Harold M.; Koike, Chiyoe; Witteborn, Fred C.; McMurtry, Craig M.

    1998-01-01

    We present 7.6 - 13.3 microns infrared (IR) spectrophotometry (R approx. = 180 - 350) of the 10 microns silicate emission from dust in the inner coma (i.e., within a diameter of 3in.) of comet C/1995 O1 (Hale-Bopp) at four temporal epochs from 1996 October through 1997 June during Hale-Bopp s approach to, arrival at, and recession from perihelion. The HIFOGS spectra at large heliocentric distances exhibit strong emission peaks from 9.9 - 10.1 microns and at 11.2 microns. The HIFOGS spectra of Hale-Bopp taken 1996 October 07 - 14 UT are identical in shape to the ISO SWS spectrum at 2.8 AU obtained on 1996 October 06 UT. Magnesium-rich olivine was unambiguously identified due to presence of the expected 11.2 microns peak along with the matching far-IR 18 microns, 23 microns, and 33 microns peaks in the ISO SWS spectrum. In contrast, to large heliocentric distances, we find that the silicate feature at small heliocentric distances (tau(sub lambda) less than or = 1.7 AU) exhibits strong peaks at 9.3 microns, 9.9 - 10.1 microns, and 11.2 microns, and weak at 10.5 microns and 11.8 microns. We will show that the dramatic increase of the 9.3 microns and 10.0 microns peaks close to perihelion leads to the hypothesis that there are two crystalline grain components with significantly different temperatures. The hotter mineral species (including olivines) radiate over a large range of heliocentric distances at detectable leve!s. The cooler mineral species (pyroxenes) radiate on the Wien side of the blackbody, too faint to detect in the mid-infrared spectra, until close to the sun when this species radiates on the Reyleigh-Jeans tail and becomes apparent. Decomposition of the observed silicate emission features into mineral components through comparison of the height and shape of the silicate feature ("Flux/cont") derived from the cometary spectra, to optical extinctions (Qext) derived from laboratory measurements of terrestrial silicate minerals and interplanetary dust

  13. Depleted Uranium | RadTown USA | US EPA

    EPA Pesticide Factsheets

    2018-01-12

    Depleted uranium is the material left after most of the highly radioactive uranium-235 is removed from uranium ore for nuclear power and weapons. DU is used for tank armor, armor-piercing bullets and as weights to help balance aircraft. DU is both a toxic chemical and radiation health hazard when inside the body.

  14. Achieving high-efficiency emission depletion nanoscopy by employing cross relaxation in upconversion nanoparticles.

    PubMed

    Zhan, Qiuqiang; Liu, Haichun; Wang, Baoju; Wu, Qiusheng; Pu, Rui; Zhou, Chao; Huang, Bingru; Peng, Xingyun; Ågren, Hans; He, Sailing

    2017-10-20

    Stimulated emission depletion microscopy provides a powerful sub-diffraction imaging modality for life science studies. Conventionally, stimulated emission depletion requires a relatively high light intensity to obtain an adequate depletion efficiency through only light-matter interaction. Here we show efficient emission depletion for a class of lanthanide-doped upconversion nanoparticles with the assistance of interionic cross relaxation, which significantly lowers the laser intensity requirements of optical depletion. We demonstrate two-color super-resolution imaging using upconversion nanoparticles (resolution ~ 66 nm) with a single pair of excitation/depletion beams. In addition, we show super-resolution imaging of immunostained cytoskeleton structures of fixed cells (resolution ~ 82 nm) using upconversion nanoparticles. These achievements provide a new perspective for the development of photoswitchable luminescent probes and will broaden the applications of lanthanide-doped nanoparticles for sub-diffraction microscopic imaging.

  15. "When the going gets tough, who keeps going?" Depletion sensitivity moderates the ego-depletion effect.

    PubMed

    Salmon, Stefanie J; Adriaanse, Marieke A; De Vet, Emely; Fennis, Bob M; De Ridder, Denise T D

    2014-01-01

    Self-control relies on a limited resource that can get depleted, a phenomenon that has been labeled ego-depletion. We argue that individuals may differ in their sensitivity to depleting tasks, and that consequently some people deplete their self-control resource at a faster rate than others. In three studies, we assessed individual differences in depletion sensitivity, and demonstrate that depletion sensitivity moderates ego-depletion effects. The Depletion Sensitivity Scale (DSS) was employed to assess depletion sensitivity. Study 1 employs the DSS to demonstrate that individual differences in sensitivity to ego-depletion exist. Study 2 shows moderate correlations of depletion sensitivity with related self-control concepts, indicating that these scales measure conceptually distinct constructs. Study 3 demonstrates that depletion sensitivity moderates the ego-depletion effect. Specifically, participants who are sensitive to depletion performed worse on a second self-control task, indicating a stronger ego-depletion effect, compared to participants less sensitive to depletion.

  16. PALM-3000: EXOPLANET ADAPTIVE OPTICS FOR THE 5 m HALE TELESCOPE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dekany, Richard; Bouchez, Antonin; Baranec, Christoph

    2013-10-20

    We describe and report first results from PALM-3000, the second-generation astronomical adaptive optics (AO) facility for the 5.1 m Hale telescope at Palomar Observatory. PALM-3000 has been engineered for high-contrast imaging and emission spectroscopy of brown dwarfs and large planetary mass bodies at near-infrared wavelengths around bright stars, but also supports general natural guide star use to V ≈ 17. Using its unique 66 × 66 actuator deformable mirror, PALM-3000 has thus far demonstrated residual wavefront errors of 141 nm rms under ∼1'' seeing conditions. PALM-3000 can provide phase conjugation correction over a 6.''4 × 6.''4 working region at λmore » = 2.2 μm, or full electric field (amplitude and phase) correction over approximately one-half of this field. With optimized back-end instrumentation, PALM-3000 is designed to enable 10{sup –7} contrast at 1'' angular separation, including post-observation speckle suppression processing. While continued optimization of the AO system is ongoing, we have already successfully commissioned five back-end instruments and begun a major exoplanet characterization survey, Project 1640.« less

  17. Fabry-Perot Observations of Comet Hale-Bopp H_2O(+) Velocity Fields

    NASA Astrophysics Data System (ADS)

    Roesler, F. L.; Klinglesmith, D. A., III; Scherb, F.; Mierkiewicz, E. J.; Oliversen, R. J.

    1997-07-01

    We have obtained Doppler-sliced images of H_2O(+) emission from Comet Hale-Bopp, using a 15-cm, dual-etalon, Fabry-Perot/CCD imaging spectrometer at the McMath-Pierce 0.8-meter west auxiliary telescope of the National Solar Observatory on Kitt Peak. The 6-arcmin field of view was centered on the comet nucleus, and the spectral resolution was 0.4 Angstroms (20km/sec). The observations consisted of ``data cubes,'' i.e., a sequence of images of the 6158 Angstroms emission doublet at velocity steps of 12.5 or 25km/sec, covering a range from -75km/sec to +75km/sec in the comet reference frame. We were able to follow the comet for 1 to 1(1/_2) hours each clear night. We obtained useable data cubes on at least ten nights between February 25 and April 16. These data are being examined to investigate the comet-solar wind interaction. We will present both still images and time-lapse movies showing sequences of ion velocities and accelerations on the plane of the sky.

  18. Groundbased Observations of [C I] 9850A Emission from Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    Doane, N. E.; Oliversen, R. J.; Scherb, F.; Morgenthaler, J. P.; Roesler, F. L.; Woodward, R. C.; Harris, W. M.; Hilton, G. M.

    1999-05-01

    High spectral resolution observations of Comet Hale-Bopp [C I] 9850A emission were obtained at the NSO McMath-Pierce main telescope on 13 nights during 1997 March 9 to 10 and April 7 to 19. Spectra with good signal-to-noise were obtained using a dual- etalon 50mm Fabry-Perot spectrometer (R 40,000) with a 6 arcmin field of view. The comet was observed over a 0.92-1.00 AU range of heliocentric distances. Most observations were centered on the comet nucleus where the surface brightness ranged from about 70 to 170 Rayleighs. Several observations were also centered approximately 5 arcmin sunward and tailward of the comet nucleus. The sunward [C I] emission was fainter than the tailward emission. Assuming that CO photodissociation is the source of cometary C(1D) (and neglecting quenching), for a surface brightness of 120 Rayleighs, we estimate a (lower limit) CO production rate of about 2x10(30) per sec. These [C I] observationsare the first extensive set reported for this cometary emission line.

  19. Molecular dynamics study of lubricant depletion by pulsed laser heating

    NASA Astrophysics Data System (ADS)

    Seo, Young Woo; Rosenkranz, Andreas; Talke, Frank E.

    2018-05-01

    In this study, molecular dynamics simulations were performed to numerically investigate the effect of pulsed laser heating on lubricant depletion. The maximum temperature, the lubricant depletion width, the number of evaporated lubricant beads and the number of fragmented lubricant chains were studied as a function of laser peak power, pulse duration and repetition rate. A continuous-wave laser and a square pulse laser were simulated and compared to a Gaussian pulse laser. With increasing repetition rate, pulsed laser heating was found to approach continuous-wave laser heating.

  20. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

    PubMed

    2017-09-16

    Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and

  1. Dust Activity of Comet Hale-Bopp (C/1995 O1) at Rh ~ 3 AU

    NASA Astrophysics Data System (ADS)

    Tozzi, G. P.; Mannucci, F.; Stanga, R.; Testi, L.

    1997-07-01

    Observations of comet Hale-Bopp (C/1995 O1) have been performed in the infrared (J, H, K bands) at the Nordic Optical Telescope (NOT), located on Canary islands, with the ARNICA (ARcetri Near Infrared CAmera). The comet was observed during two periods, at the beginning and the end of September 1996, when the comet was at heliocentric distances rh of ~ 3.3 and 2.9 AU, respectively. The data show a relatively large activity of the comet with production of some outbursts, the largest of which happened some time before the start of the second run (24.8 Sept.) and which may be the further evolution of the outburst detected by the HST (Weaver et al., 1997, Science 275, 1900). Here we present the analysis of the data with particular attention to the evolution of the outbursts and the photometric IR color index of the dust released.

  2. Morfología de la Coma del Cometa Hale - Bopp

    NASA Astrophysics Data System (ADS)

    Gil-Hutton, R.; Caballero, M.; Coldwell, G.; Cañada, M.; Godoy, G.; Trozzo, C.; Gómez, G.

    Para lograr comprender plenamente los procesos físicos que se desarrollan en los núcleos cometarios y obtener un modelo que explique, no sólo su actividad, sino también sus efectos sobre la coma, es necesario obtener información detallada para el mayor número de cometas posible, siendo las características más interesantes para estudiar la ubicación de las regiones activas, la presencia de jets, las tasas de producción de gas y polvo y la interacción de la coma con el viento solar. En la actualidad, con técnicas de procesamiento de imágenes y tecnología CCD se pueden obtener este tipo de datos para cometas que ingresan al sistema solar interior y estudiar, de esta manera, la morfología de sus comas, tratando de correlacionar la actividad detectada con algún modelo teórico. En este trabajo se presenta un estudio parcial de la actividad desarrollada por el cometa Hale-Bopp, y sus efectos sobre la morfología de su coma, desde agosto de 1995 hasta la fecha en base a imágenes adquiridas con el telescopio de 0.76 m. de la Estación Astronómica Dr. Carlos Ulrrico Cesco.

  3. Ego depletion in visual perception: Ego-depleted viewers experience less ambiguous figure reversal.

    PubMed

    Wimmer, Marina C; Stirk, Steven; Hancock, Peter J B

    2017-10-01

    This study examined the effects of ego depletion on ambiguous figure perception. Adults (N = 315) received an ego depletion task and were subsequently tested on their inhibitory control abilities that were indexed by the Stroop task (Experiment 1) and their ability to perceive both interpretations of ambiguous figures that was indexed by reversal (Experiment 2). Ego depletion had a very small effect on reducing inhibitory control (Cohen's d = .15) (Experiment 1). Ego-depleted participants had a tendency to take longer to respond in Stroop trials. In Experiment 2, ego depletion had small to medium effects on the experience of reversal. Ego-depleted viewers tended to take longer to reverse ambiguous figures (duration to first reversal) when naïve of the ambiguity and experienced less reversal both when naïve and informed of the ambiguity. Together, findings suggest that ego depletion has small effects on inhibitory control and small to medium effects on bottom-up and top-down perceptual processes. The depletion of cognitive resources can reduce our visual perceptual experience.

  4. Temperature dependent simulation of diamond depleted Schottky PIN diodes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hathwar, Raghuraj; Dutta, Maitreya; Chowdhury, Srabanti

    2016-06-14

    Diamond is considered as an ideal material for high field and high power devices due to its high breakdown field, high lightly doped carrier mobility, and high thermal conductivity. The modeling and simulation of diamond devices are therefore important to predict the performances of diamond based devices. In this context, we use Silvaco{sup ®} Atlas, a drift-diffusion based commercial software, to model diamond based power devices. The models used in Atlas were modified to account for both variable range and nearest neighbor hopping transport in the impurity bands associated with high activation energies for boron doped and phosphorus doped diamond.more » The models were fit to experimentally reported resistivity data over a wide range of doping concentrations and temperatures. We compare to recent data on depleted diamond Schottky PIN diodes demonstrating low turn-on voltages and high reverse breakdown voltages, which could be useful for high power rectifying applications due to the low turn-on voltage enabling high forward current densities. Three dimensional simulations of the depleted Schottky PIN diamond devices were performed and the results are verified with experimental data at different operating temperatures.« less

  5. Dopamine depletion increases the power and coherence of high-voltage spindles in the globus pallidus and motor cortex of freely moving rats.

    PubMed

    Ge, Shunnan; Yang, Chen; Li, Min; Li, Jiang; Chang, Xiaozan; Fu, Jian; Chen, Lei; Chang, Chongwang; Wang, Xuelian; Zhu, Junling; Gao, Guodong

    2012-07-17

    Studies on patients with Parkinson's disease and in animal models have observed enhanced synchronization of oscillations in several frequency bands within and between the cortical-basal ganglia (BG) structures. Recent research has also shown that synchronization of high-voltage spindles (HVSs) in the cortex, striatum and substantia nigra pars reticulate is increased by dopamine depletion. However, more evidence is needed to determine whether HVS activity in the whole cortex-BG network represents homologous alteration following dopamine depletion. As the globus pallidus (GP) is in a central position to propagate and synchronize oscillations in the cortical-BG circuits, we employed local-field potentials and electrocorticogram to simultaneously record oscillations in the GP and primary (M1) and secondary (M2) motor cortices on freely moving 6-hydroxydopamine (6-OHDA) lesioned and control rats. Results showed that HVS episodes recorded from GP, and M2 and M1 cortex areas were more numerous and longer in 6-OHDA lesioned rats compared to controls. Relative power associated with HVS activity in the GP, and M2 and M1 cortices of 6-OHDA lesioned rats was significantly greater than that for control rats. Coherence values for HVS activity between the GP, and M2 and M1 cortex areas were significantly increased by dopamine depletion. Time lag between the M1 cortex HVS and GP HVS was significantly shorter for dopamine depleted than normal rats. Findings indicate a crucial rule for dopamine in the regulation of HVS activity in the whole cortical-BG circuit, and suggest a close relationship between abnormally synchronized HVS oscillations in the cortex-BG network and Parkinson's disease. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. Water Depletion Threatens Agriculture

    NASA Astrophysics Data System (ADS)

    Brauman, K. A.; Richter, B. D.; Postel, S.; Floerke, M.; Malsy, M.

    2014-12-01

    Irrigated agriculture is the human activity that has by far the largest impact on water, constituting 85% of global water consumption and 67% of global water withdrawals. Much of this water use occurs in places where water depletion, the ratio of water consumption to water availability, exceeds 75% for at least one month of the year. Although only 17% of global watershed area experiences depletion at this level or more, nearly 30% of total cropland and 60% of irrigated cropland are found in these depleted watersheds. Staple crops are particularly at risk, with 75% of global irrigated wheat production and 65% of irrigated maize production found in watersheds that are at least seasonally depleted. Of importance to textile production, 75% of cotton production occurs in the same watersheds. For crop production in depleted watersheds, we find that one half to two-thirds of production occurs in watersheds that have not just seasonal but annual water shortages, suggesting that re-distributing water supply over the course of the year cannot be an effective solution to shortage. We explore the degree to which irrigated production in depleted watersheds reflects limitations in supply, a byproduct of the need for irrigation in perennially or seasonally dry landscapes, and identify heavy irrigation consumption that leads to watershed depletion in more humid climates. For watersheds that are not depleted, we evaluate the potential impact of an increase in irrigated production. Finally, we evaluate the benefits of irrigated agriculture in depleted and non-depleted watersheds, quantifying the fraction of irrigated production going to food production, animal feed, and biofuels.

  7. “When the going gets tough, who keeps going?” Depletion sensitivity moderates the ego-depletion effect

    PubMed Central

    Salmon, Stefanie J.; Adriaanse, Marieke A.; De Vet, Emely; Fennis, Bob M.; De Ridder, Denise T. D.

    2014-01-01

    Self-control relies on a limited resource that can get depleted, a phenomenon that has been labeled ego-depletion. We argue that individuals may differ in their sensitivity to depleting tasks, and that consequently some people deplete their self-control resource at a faster rate than others. In three studies, we assessed individual differences in depletion sensitivity, and demonstrate that depletion sensitivity moderates ego-depletion effects. The Depletion Sensitivity Scale (DSS) was employed to assess depletion sensitivity. Study 1 employs the DSS to demonstrate that individual differences in sensitivity to ego-depletion exist. Study 2 shows moderate correlations of depletion sensitivity with related self-control concepts, indicating that these scales measure conceptually distinct constructs. Study 3 demonstrates that depletion sensitivity moderates the ego-depletion effect. Specifically, participants who are sensitive to depletion performed worse on a second self-control task, indicating a stronger ego-depletion effect, compared to participants less sensitive to depletion. PMID:25009523

  8. Gullies at the Edge of Hale Crater, Mars

    NASA Image and Video Library

    2009-09-02

    This image from the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter shows gullies near the edge of Hale crater on southern Mars. The view covers an area about 1 kilometer (0.6 mile) across and was taken on Aug. 3, 2009. Martian gullies carved into hill slopes and the walls of impact craters were discovered several years ago. Scientists are excited to study these features because, on Earth, they usually form through the action of liquid water -- long thought to be absent on the Martian surface. Whether liquid water carves gullies under today's cold and dry conditions on Mars is a major question that planetary scientists are trying to answer. The gullies pictured here are examples of what a typical Martian gully looks like. You can see wide V-shaped channels running downhill (from top to bottom) where the material that carved the gully flowed. At the bottom of the channel this material empties out onto a fan-shaped mound. The fans from each gully overlap one other in complicated ways. At the tops of the channels, large amphitheater-shaped alcoves are carved in the rock. The material removed from these alcoves likely flowed downhill to the aprons through the gullies. The terrain in this image is at 36.5 degrees south latitude, 322.7 degrees east longitude. Gullies at this site are especially interesting because scientists recently discovered actively changing examples at similar locations. Images separated by several years showed changes in the appearance of some of these gullies. Today, planetary scientists are using the HiRISE camera to examine gullies such as the one in this image for change that might provide a clue about whether liquid water occurs on the surface of Mars. http://photojournal.jpl.nasa.gov/catalog/PIA12194

  9. 12. VIEW OF DEPLETED URANIUM INGOT AND MOLDS. DEPLETED URANIUM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF DEPLETED URANIUM INGOT AND MOLDS. DEPLETED URANIUM CASTING OPERATIONS CEASED IN 1988. (11/14/57) - Rocky Flats Plant, Non-Nuclear Production Facility, South of Cottonwood Avenue, west of Seventh Avenue & east of Building 460, Golden, Jefferson County, CO

  10. Production, Outflow Velocity, and Radial Distribution of H2O and OH in the Coma of Comet C/1995 O1 [Hale-Bopp] from Wide Field Imaging of OH

    NASA Technical Reports Server (NTRS)

    Harris, Walter M.; Scherb, Frank; Mierkiewicz, Edwin; Oliverson, Ronald; Morgenthaler, Jeffrey

    2003-01-01

    Observations of OH are a useful proxy of the water production rate (Q(sub H2O)) and outflow velocity (V(sub out)) in comets. From wide field images taken on 03/28/1997 and 04/08/1997 that capture the entire scale length of the OH coma of comet C/1995 O1 (Hale-Bopp), we obtain Q(sub H2O) from the model-independent method of aperture summation. With an adaptive ring summation algorithm, we extract the radial brightness distribution of OH 0-0 band emission out to cometocentric distances of up to 10(exp 6) km, both as azimuthal averages and in quadrants covering different position angles relative to the comet-Sun line. These profiles are fit using both fixed and variable velocity 2-component spherical expansion models to estimate V(sub OH) with increasing distance from the nucleus. The OH coma of Hale-Bopp was more spatially extended than previous comets, and this extension is best matched by a variable acceleration of H2O and OH that acted across the entire coma, but was strongest within 1-2 x 10(exp 4) km from the nucleus. Our models indicate that V(sub OH) at the edge of our detectable field of view (10(exp 6) km) was approx. 2-3 times greater in Hale-Bopp than for a 1P/Halley-class comet at 1 AU, which is consistent with the results of more sophisticated gas-kinetic models, extrapolation from previous observations of OH in comets with Q(sub H2O) greater than 10(exp 29)/s , and direct radio measurements of the outer coma Hale-Bopp OH velocity. The most probable source of this acceleration is thermalization of the excess energy of dissociation of H2O and OH over an extended collisional coma. When the coma is broken down by quadrants in position angle, we find an azimuthal asymmetry in the radial distribution that is characterized by an increase in the spatial extent of OH in the region between the orbit-trailing and anti-sunward directions. Model fits specific to this area and comparison with radio OH measurements suggest greater acceleration here, with V(sub OH

  11. Theoretical analysis and simulation study of low-power CMOS electrochemical impedance spectroscopy biosensor in 55 nm deeply depleted channel technology for cell-state monitoring

    NASA Astrophysics Data System (ADS)

    Itakura, Keisuke; Kayano, Keisuke; Nakazato, Kazuo; Niitsu, Kiichi

    2018-01-01

    We present an impedance-detection complementary metal oxide semiconductor (CMOS) biosensor circuit for cell-state observation. The proposed biosensor can measure the expected impedance values encountered by a cell-state observation measurement system within a 0.1-200 MHz frequency range. The proposed device is capable of monitoring the intracellular conditions necessary for real-time cell-state observation, and can be fabricated using a 55 nm deeply depleted channel CMOS process. Operation of the biosensor circuit with 0.9 and 1.7 V supply voltages is verified via a simulated program with integrated circuit emphasis (SPICE) simulation. The power consumption is 300 µW. Further, the standby power consumption is 290 µW, indicating that this biosensor is a low-power instrument suitable for use in Internet of Things (IoT) devices.

  12. Depletion layer recombination effects on the radiation damage hardness of gallium arsenide cells

    NASA Technical Reports Server (NTRS)

    Garlick, G. F. J.

    1985-01-01

    The significant effect of junction depletion layer recombination on the efficiency of windowed GaAs cells was demonstrated. The effect becomes more pronounced as radiation damage occurs. The depletion is considered for 1 MeV electron fluences up to 10 to the 16th power e/sq m. The cell modeling separates damage in emitter and base or buffer layers using different damage coefficients is reported. The lower coefficient for the emitter predicts less loss of performance at fluences greater than 10 to the 15th power e/sq cm. A method for obtaining information on junction recombination effects as damage proceeds is described; this enables a more complete diagnosis of damage to be made.

  13. Neutral-depletion-induced axially asymmetric density in a helicon source and imparted thrust

    NASA Astrophysics Data System (ADS)

    Takahashi, Kazunori; Takao, Yoshinori; Ando, Akira

    2016-02-01

    The high plasma density downstream of the source is observed to be sustained only for a few hundreds of microsecond at the initial phase of the discharge, when pulsing the radiofrequency power of a helicon plasma thruster. Measured relative density of argon neutrals inside the source implies that the neutrals are significantly depleted there. A position giving a maximum plasma density temporally moves to the upstream side of the source due to the neutral depletion and then the exhausted plasma density significantly decreases. The direct thrust measurement demonstrates that the higher thrust-to-power ratio is obtained by using only the initial phase of the high density plasma, compared with the steady-state operation.

  14. The Toxicity of Depleted Uranium

    PubMed Central

    Briner, Wayne

    2010-01-01

    Depleted uranium (DU) is an emerging environmental pollutant that is introduced into the environment primarily by military activity. While depleted uranium is less radioactive than natural uranium, it still retains all the chemical toxicity associated with the original element. In large doses the kidney is the target organ for the acute chemical toxicity of this metal, producing potentially lethal tubular necrosis. In contrast, chronic low dose exposure to depleted uranium may not produce a clear and defined set of symptoms. Chronic low-dose, or subacute, exposure to depleted uranium alters the appearance of milestones in developing organisms. Adult animals that were exposed to depleted uranium during development display persistent alterations in behavior, even after cessation of depleted uranium exposure. Adult animals exposed to depleted uranium demonstrate altered behaviors and a variety of alterations to brain chemistry. Despite its reduced level of radioactivity evidence continues to accumulate that depleted uranium, if ingested, may pose a radiologic hazard. The current state of knowledge concerning DU is discussed. PMID:20195447

  15. Tuning donut profile for spatial resolution in stimulated emission depletion microscopy.

    PubMed

    Neupane, Bhanu; Chen, Fang; Sun, Wei; Chiu, Daniel T; Wang, Gufeng

    2013-04-01

    In stimulated emission depletion (STED)-based or up-conversion depletion-based super-resolution optical microscopy, the donut-shaped depletion beam profile is of critical importance to its resolution. In this study, we investigate the transformation of the donut-shaped depletion beam focused by a high numerical aperture (NA) microscope objective, and model STED point spread function (PSF) as a function of donut beam profile. We show experimentally that the intensity profile of the dark kernel of the donut can be approximated as a parabolic function, whose slope is determined by the donut beam size before the objective back aperture, or the effective NA. Based on this, we derive the mathematical expression for continuous wave (CW) STED PSF as a function of focal plane donut and excitation beam profiles, as well as dye properties. We find that the effective NA and the residual intensity at the center are critical factors for STED imaging quality and the resolution. The effective NA is critical for STED resolution in that it not only determines the donut shape but also the area the depletion laser power is dispersed. An improperly expanded depletion beam will have negligible improvement in resolution. The polarization of the depletion beam also plays an important role as it affects the residual intensity in the center of the donut. Finally, we construct a CW STED microscope operating at 488 nm excitation and 592 nm depletion with a resolution of 70 nm. Our study provides detailed insight to the property of donut beam, and parameters that are important for the optimal performance of STED microscopes. This paper will provide a useful guide for the construction and future development of STED microscopes.

  16. The modality effect of ego depletion: Auditory task modality reduces ego depletion.

    PubMed

    Li, Qiong; Wang, Zhenhong

    2016-08-01

    An initial act of self-control that impairs subsequent acts of self-control is called ego depletion. The ego depletion phenomenon has been observed consistently. The modality effect refers to the effect of the presentation modality on the processing of stimuli. The modality effect was also robustly found in a large body of research. However, no study to date has examined the modality effects of ego depletion. This issue was addressed in the current study. In Experiment 1, after all participants completed a handgrip task, one group's participants completed a visual attention regulation task and the other group's participants completed an auditory attention regulation task, and then all participants again completed a handgrip task. The ego depletion phenomenon was observed in both the visual and the auditory attention regulation task. Moreover, participants who completed the visual task performed worse on the handgrip task than participants who completed the auditory task, which indicated that there was high ego depletion in the visual task condition. In Experiment 2, participants completed an initial task that either did or did not deplete self-control resources, and then they completed a second visual or auditory attention control task. The results indicated that depleted participants performed better on the auditory attention control task than the visual attention control task. These findings suggest that altering task modality may reduce ego depletion. © 2016 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  17. Ego depletion increases risk-taking.

    PubMed

    Fischer, Peter; Kastenmüller, Andreas; Asal, Kathrin

    2012-01-01

    We investigated how the availability of self-control resources affects risk-taking inclinations and behaviors. We proposed that risk-taking often occurs from suboptimal decision processes and heuristic information processing (e.g., when a smoker suppresses or neglects information about the health risks of smoking). Research revealed that depleted self-regulation resources are associated with reduced intellectual performance and reduced abilities to regulate spontaneous and automatic responses (e.g., control aggressive responses in the face of frustration). The present studies transferred these ideas to the area of risk-taking. We propose that risk-taking is increased when individuals find themselves in a state of reduced cognitive self-control resources (ego-depletion). Four studies supported these ideas. In Study 1, ego-depleted participants reported higher levels of sensation seeking than non-depleted participants. In Study 2, ego-depleted participants showed higher levels of risk-tolerance in critical road traffic situations than non-depleted participants. In Study 3, we ruled out two alternative explanations for these results: neither cognitive load nor feelings of anger mediated the effect of ego-depletion on risk-taking. Finally, Study 4 clarified the underlying psychological process: ego-depleted participants feel more cognitively exhausted than non-depleted participants and thus are more willing to take risks. Discussion focuses on the theoretical and practical implications of these findings.

  18. Transequatorial Propagation and Depletion Precursors

    NASA Astrophysics Data System (ADS)

    Miller, E. S.; Bust, G. S.; Kaeppler, S. R.; Frissell, N. A.; Paxton, L. J.

    2014-12-01

    The bottomside equatorial ionosphere in the afternoon and evening sector frequently evolves rapidly from smoothly stratified to violently unstable with large wedges of depleted plasma growing through to the topside on timescales of a few tens of minutes. These depletions have numerous practical impacts on radio propagation, including amplitude scintillation, field-aligned irregularity scatter, HF blackouts, and long-distance transequatorial propagation at frequencies above the MUF. Practical impacts notwithstanding, the pathways and conditions under which depletions form remain a topic of vigorous inquiry some 80 years after their first report. Structuring of the pre-sunset ionosphere---morphology of the equatorial anomalies and long-wavelength undulations of the isodensity contours on the bottomside---are likely to hold some clues to conditions that are conducive to depletion formation. The Conjugate Depletion Experiment is an upcoming transequatorial forward-scatter HF/VHF experiment to investigate pre-sunset undulations and their connection with depletion formation. We will present initial results from the Conjugate Depletion Experiment, as well as a companion analysis of a massive HF propagation data set.

  19. Standardization of formulations for the acute amino acid depletion and loading tests.

    PubMed

    Badawy, Abdulla A-B; Dougherty, Donald M

    2015-04-01

    The acute tryptophan depletion and loading and the acute tyrosine plus phenylalanine depletion tests are powerful tools for studying the roles of cerebral monoamines in behaviour and symptoms related to various disorders. The tests use either amino acid mixtures or proteins. Current amino acid mixtures lack specificity in humans, but not in rodents, because of the faster disposal of branched-chain amino acids (BCAAs) by the latter. The high content of BCAA (30-60%) is responsible for the poor specificity in humans and we recommend, in a 50g dose, a control formulation with a lowered BCAA content (18%) as a common control for the above tests. With protein-based formulations, α-lactalbumin is specific for acute tryptophan loading, whereas gelatine is only partially effective for acute tryptophan depletion. We recommend the use of the whey protein fraction glycomacropeptide as an alternative protein. Its BCAA content is ideal for specificity and the absence of tryptophan, tyrosine and phenylalanine render it suitable as a template for seven formulations (separate and combined depletion or loading and a truly balanced control). We invite the research community to participate in standardization of the depletion and loading methodologies by using our recommended amino acid formulation and developing those based on glycomacropeptide. © The Author(s) 2015.

  20. The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans

    PubMed Central

    Zhang, Liangyu; Ward, Jordan D.; Cheng, Ze; Dernburg, Abby F.

    2015-01-01

    Experimental manipulation of protein abundance in living cells or organisms is an essential strategy for investigation of biological regulatory mechanisms. Whereas powerful techniques for protein expression have been developed in Caenorhabditis elegans, existing tools for conditional disruption of protein function are far more limited. To address this, we have adapted the auxin-inducible degradation (AID) system discovered in plants to enable conditional protein depletion in C. elegans. We report that expression of a modified Arabidopsis TIR1 F-box protein mediates robust auxin-dependent depletion of degron-tagged targets. We document the effectiveness of this system for depletion of nuclear and cytoplasmic proteins in diverse somatic and germline tissues throughout development. Target proteins were depleted in as little as 20-30 min, and their expression could be re-established upon auxin removal. We have engineered strains expressing TIR1 under the control of various promoter and 3′ UTR sequences to drive tissue-specific or temporally regulated expression. The degron tag can be efficiently introduced by CRISPR/Cas9-based genome editing. We have harnessed this system to explore the roles of dynamically expressed nuclear hormone receptors in molting, and to analyze meiosis-specific roles for proteins required for germ line proliferation. Together, our results demonstrate that the AID system provides a powerful new tool for spatiotemporal regulation and analysis of protein function in a metazoan model organism. PMID:26552885

  1. Depletion-of-Battery Attack: Specificity, Modelling and Analysis.

    PubMed

    Shakhov, Vladimir; Koo, Insoo

    2018-06-06

    The emerging Internet of Things (IoT) has great potential; however, the societal costs of the IoT can outweigh its benefits. To unlock IoT potential, there needs to be improvement in the security of IoT applications. There are several standardization initiatives for sensor networks, which eventually converge with the Internet of Things. As sensor-based applications are deployed, security emerges as an essential requirement. One of the critical issues of wireless sensor technology is limited sensor resources, including sensor batteries. This creates a vulnerability to battery-exhausting attacks. Rapid exhaustion of sensor battery power is not only explained by intrusions, but can also be due to random failure of embedded sensor protocols. Thus, most wireless sensor applications, without tools to defend against rash battery exhausting, would be unable to function during prescribed times. In this paper, we consider a special type of threat, in which the harm is malicious depletion of sensor battery power. In contrast to the traditional denial-of-service attack, quality of service under the considered attack is not necessarily degraded. Moreover, the quality of service can increase up to the moment of the sensor set crashes. We argue that this is a distinguishing type of attack. Hence, the application of a traditional defense mechanism against this threat is not always possible. Therefore, effective methods should be developed to counter the threat. We first discuss the feasibility of rash depletion of battery power. Next, we propose a model for evaluation of energy consumption when under attack. Finally, a technique to counter the attack is discussed.

  2. Depletion region surface effects in electron beam induced current measurements.

    PubMed

    Haney, Paul M; Yoon, Heayoung P; Gaury, Benoit; Zhitenev, Nikolai B

    2016-09-07

    Electron beam induced current (EBIC) is a powerful characterization technique which offers the high spatial resolution needed to study polycrystalline solar cells. Current models of EBIC assume that excitations in the p - n junction depletion region result in perfect charge collection efficiency. However we find that in CdTe and Si samples prepared by focused ion beam (FIB) milling, there is a reduced and nonuniform EBIC lineshape for excitations in the depletion region. Motivated by this, we present a model of the EBIC response for excitations in the depletion region which includes the effects of surface recombination from both charge-neutral and charged surfaces. For neutral surfaces we present a simple analytical formula which describes the numerical data well, while the charged surface response depends qualitatively on the location of the surface Fermi level relative to the bulk Fermi level. We find the experimental data on FIB-prepared Si solar cells is most consistent with a charged surface, and discuss the implications for EBIC experiments on polycrystalline materials.

  3. Depletion region surface effects in electron beam induced current measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haney, Paul M.; Zhitenev, Nikolai B.; Yoon, Heayoung P.

    2016-09-07

    Electron beam induced current (EBIC) is a powerful characterization technique which offers the high spatial resolution needed to study polycrystalline solar cells. Current models of EBIC assume that excitations in the p-n junction depletion region result in perfect charge collection efficiency. However, we find that in CdTe and Si samples prepared by focused ion beam (FIB) milling, there is a reduced and nonuniform EBIC lineshape for excitations in the depletion region. Motivated by this, we present a model of the EBIC response for excitations in the depletion region which includes the effects of surface recombination from both charge-neutral and chargedmore » surfaces. For neutral surfaces, we present a simple analytical formula which describes the numerical data well, while the charged surface response depends qualitatively on the location of the surface Fermi level relative to the bulk Fermi level. We find that the experimental data on FIB-prepared Si solar cells are most consistent with a charged surface and discuss the implications for EBIC experiments on polycrystalline materials.« less

  4. An Early Investigation Of The Striated Tail Of Comet Hale-Bopp (C/1995 O1)

    NASA Astrophysics Data System (ADS)

    Pittichová, J.; Sekanina, Z.; Birkle, K.; Boehnhardt, H.; Engels, D.; Keller, P.

    1997-07-01

    The Sekanina-Farrell particle fragmentation model for the striated tails of dust comets is successfully applied to two images of comet Hale-Bopp to study the motions of 12 striae in a time span of March 12 15, 1997. There is evidence for recurring outbursts with a periodicity of 11h21m, consistent with results based on analysis of dust jets. The ejecta in all the striae appear to have been released from one source on the nucleus between the end of January and the second half of February 1997, some 60 to 40 days before perihelion. The parent particles were subjected to a radiation pressure acceleration of βp ≃ 0.55 and their fragmentation lifetimes in 11 of the 12 striae were practically constant and equal to 13 15 days, when normalized to 1 AU from the Sun. Brief analysis of Watanabe et al.'s measurements of striae on their images from March 5 9, 1997 shows even shorter fragmentation lifetimes for the parent particles, mostly about 7 11 days at1 AU.

  5. Ego depletion impairs implicit learning.

    PubMed

    Thompson, Kelsey R; Sanchez, Daniel J; Wesley, Abigail H; Reber, Paul J

    2014-01-01

    Implicit skill learning occurs incidentally and without conscious awareness of what is learned. However, the rate and effectiveness of learning may still be affected by decreased availability of central processing resources. Dual-task experiments have generally found impairments in implicit learning, however, these studies have also shown that certain characteristics of the secondary task (e.g., timing) can complicate the interpretation of these results. To avoid this problem, the current experiments used a novel method to impose resource constraints prior to engaging in skill learning. Ego depletion theory states that humans possess a limited store of cognitive resources that, when depleted, results in deficits in self-regulation and cognitive control. In a first experiment, we used a standard ego depletion manipulation prior to performance of the Serial Interception Sequence Learning (SISL) task. Depleted participants exhibited poorer test performance than did non-depleted controls, indicating that reducing available executive resources may adversely affect implicit sequence learning, expression of sequence knowledge, or both. In a second experiment, depletion was administered either prior to or after training. Participants who reported higher levels of depletion before or after training again showed less sequence-specific knowledge on the post-training assessment. However, the results did not allow for clear separation of ego depletion effects on learning versus subsequent sequence-specific performance. These results indicate that performance on an implicitly learned sequence can be impaired by a reduction in executive resources, in spite of learning taking place outside of awareness and without conscious intent.

  6. Ego Depletion Impairs Implicit Learning

    PubMed Central

    Thompson, Kelsey R.; Sanchez, Daniel J.; Wesley, Abigail H.; Reber, Paul J.

    2014-01-01

    Implicit skill learning occurs incidentally and without conscious awareness of what is learned. However, the rate and effectiveness of learning may still be affected by decreased availability of central processing resources. Dual-task experiments have generally found impairments in implicit learning, however, these studies have also shown that certain characteristics of the secondary task (e.g., timing) can complicate the interpretation of these results. To avoid this problem, the current experiments used a novel method to impose resource constraints prior to engaging in skill learning. Ego depletion theory states that humans possess a limited store of cognitive resources that, when depleted, results in deficits in self-regulation and cognitive control. In a first experiment, we used a standard ego depletion manipulation prior to performance of the Serial Interception Sequence Learning (SISL) task. Depleted participants exhibited poorer test performance than did non-depleted controls, indicating that reducing available executive resources may adversely affect implicit sequence learning, expression of sequence knowledge, or both. In a second experiment, depletion was administered either prior to or after training. Participants who reported higher levels of depletion before or after training again showed less sequence-specific knowledge on the post-training assessment. However, the results did not allow for clear separation of ego depletion effects on learning versus subsequent sequence-specific performance. These results indicate that performance on an implicitly learned sequence can be impaired by a reduction in executive resources, in spite of learning taking place outside of awareness and without conscious intent. PMID:25275517

  7. Exposure to nature counteracts aggression after depletion.

    PubMed

    Wang, Yan; She, Yihan; Colarelli, Stephen M; Fang, Yuan; Meng, Hui; Chen, Qiuju; Zhang, Xin; Zhu, Hongwei

    2018-01-01

    Acts of self-control are more likely to fail after previous exertion of self-control, known as the ego depletion effect. Research has shown that depleted participants behave more aggressively than non-depleted participants, especially after being provoked. Although exposure to nature (e.g., a walk in the park) has been predicted to replenish resources common to executive functioning and self-control, the extent to which exposure to nature may counteract the depletion effect on aggression has yet to be determined. The present study investigated the effects of exposure to nature on aggression following depletion. Aggression was measured by the intensity of noise blasts participants delivered to an ostensible opponent in a competition reaction-time task. As predicted, an interaction occurred between depletion and environmental manipulations for provoked aggression. Specifically, depleted participants behaved more aggressively in response to provocation than non-depleted participants in the urban condition. However, provoked aggression did not differ between depleted and non-depleted participants in the natural condition. Moreover, within the depletion condition, participants in the natural condition had lower levels of provoked aggression than participants in the urban condition. This study suggests that a brief period of nature exposure may restore self-control and help depleted people regain control over aggressive urges. © 2017 Wiley Periodicals, Inc.

  8. Production, Outflow Velocity, and Radial Distribution of H2O and OH in the Coma of Comet C/1995 O1 [Hale-Bopp] from Wide Field Imaging of OH

    NASA Technical Reports Server (NTRS)

    Harris, Walter M.; Scherb, Frank; Mierkiewicz, Edwin; Oliversen, Ronald; Morgenthaler, Jeffrey

    2001-01-01

    Observations of OH are a useful proxy of the water production rate (Q(sub H2O)) and outflow velocity (V(sub out)) in comets. We use wide field images taken on 03/28/1997 and 04/08/1997 that capture the entire scale length of the OH coma of comet C/1995O1 (Hale-Bopp) to obtain Q(sub H2O) from the model-independent method of aperture summation. We also extract the radial brightness profile of OH 3080 angstroms out to cometocentric distances of up to 10(exp 6) km using an adaptive ring summation algorithm. Radial profiles are obtained as azimuthal averages and in quadrants covering different position angles relative to the comet-Sun line. These profiles are fit using both fixed and variable velocity two-component spherical expansion models to determine VOH with increasing distance from the nucleus. The OH coma of Hale-Bopp was more spatially extended than in previous comets, and this extension is best matched by a variable acceleration of H2O and OH that acted across the entire coma, but was strongest within 1-2 x 10(exp 4) km from the nucleus. This acceleration led to VOH at 10(exp 6) km that was 2-3 times greater than that obtained from a 1P/Halleytype comet at 1 AU, a result that is consistent with gas-kinetic models, extrapolation from previous observations of OH in comets with Q(sub H2O) > 10(exp 29)/s, and radio measurements of the outer coma Hale-Bopp OH velocity profile. When the coma is broken down by quadrant, we find an azimuthal asymmetry in the radial distribution that is characterized by an increase in the spatial extent of OH in the region between the orbit-trailing and anti-sunward directions. Model fits to this area and comparison with radio OH measurements suggest greater acceleration in this region, with VOH UP to 1.5 times greater at 10(exp 6) km radial distance than elsewhere in the coma.

  9. Solar powered multipurpose remotely powered aircraft

    NASA Technical Reports Server (NTRS)

    Alexandrou, A. N.; Durgin, W. W.; Cohn, R. F.; Olinger, D. J.; Cody, Charlotte K.; Chan, Agnes; Cheung, Kwok-Hung; Conley, Kristin; Crivelli, Paul M.; Javorski, Christian T.

    1992-01-01

    Increase in energy demands coupled with rapid depletion of natural energy resources have deemed solar energy as an attractive alternative source of power. The focus was to design and construct a solar powered, remotely piloted vehicle to demonstrate the feasibility of solar energy as an effective, alternate source of power. The final design included minimizing the power requirements and maximizing the strength-to-weight and lift-to-drag ratios. Given the design constraints, Surya (the code-name given to the aircraft), is a lightweight aircraft primarily built using composite materials and capable of achieving level flight powered entirely by solar energy.

  10. Lubricant depletion under various laser heating conditions in Heat Assisted Magnetic Recording (HAMR)

    NASA Astrophysics Data System (ADS)

    Xiong, Shaomin; Wu, Haoyu; Bogy, David

    2014-09-01

    Heat assisted magnetic recording (HAMR) is expected to increase the storage areal density to more than 1 Tb/in2 in hard disk drives (HDDs). In this technology, a laser is used to heat the magnetic media to the Curie point (~400-600 °C) during the writing process. The lubricant on the top of a magnetic disk could evaporate and be depleted under the laser heating. The change of the lubricant can lead to instability of the flying slider and failure of the head-disk interface (HDI). In this study, a HAMR test stage is developed to study the lubricant thermal behavior. Various heating conditions are controlled for the study of the lubricant thermal depletion. The effects of laser heating repetitions and power levels on the lubricant depletion are investigated experimentally. The lubricant reflow behavior is discussed as well.

  11. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

    PubMed

    Murray, Christopher J L; Barber, Ryan M; Foreman, Kyle J; Abbasoglu Ozgoren, Ayse; Abd-Allah, Foad; Abera, Semaw F; Aboyans, Victor; Abraham, Jerry P; Abubakar, Ibrahim; Abu-Raddad, Laith J; Abu-Rmeileh, Niveen M; Achoki, Tom; Ackerman, Ilana N; Ademi, Zanfina; Adou, Arsène K; Adsuar, José C; Afshin, Ashkan; Agardh, Emilie E; Alam, Sayed Saidul; Alasfoor, Deena; Albittar, Mohammed I; Alegretti, Miguel A; Alemu, Zewdie A; Alfonso-Cristancho, Rafael; Alhabib, Samia; Ali, Raghib; Alla, François; Allebeck, Peter; Almazroa, Mohammad A; Alsharif, Ubai; Alvarez, Elena; Alvis-Guzman, Nelson; Amare, Azmeraw T; Ameh, Emmanuel A; Amini, Heresh; Ammar, Walid; Anderson, H Ross; Anderson, Benjamin O; Antonio, Carl Abelardo T; Anwari, Palwasha; Arnlöv, Johan; Arsic Arsenijevic, Valentina S; Artaman, Al; Asghar, Rana J; Assadi, Reza; Atkins, Lydia S; Avila, Marco A; Awuah, Baffour; Bachman, Victoria F; Badawi, Alaa; Bahit, Maria C; Balakrishnan, Kalpana; Banerjee, Amitava; Barker-Collo, Suzanne L; Barquera, Simon; Barregard, Lars; Barrero, Lope H; Basu, Arindam; Basu, Sanjay; Basulaiman, Mohammed O; Beardsley, Justin; Bedi, Neeraj; Beghi, Ettore; Bekele, Tolesa; Bell, Michelle L; Benjet, Corina; Bennett, Derrick A; Bensenor, Isabela M; Benzian, Habib; Bernabé, Eduardo; Bertozzi-Villa, Amelia; Beyene, Tariku J; Bhala, Neeraj; Bhalla, Ashish; Bhutta, Zulfiqar A; Bienhoff, Kelly; Bikbov, Boris; Biryukov, Stan; Blore, Jed D; Blosser, Christopher D; Blyth, Fiona M; Bohensky, Megan A; Bolliger, Ian W; Bora Başara, Berrak; Bornstein, Natan M; Bose, Dipan; Boufous, Soufiane; Bourne, Rupert R A; Boyers, Lindsay N; Brainin, Michael; Brayne, Carol E; Brazinova, Alexandra; Breitborde, Nicholas J K; Brenner, Hermann; Briggs, Adam D; Brooks, Peter M; Brown, Jonathan C; Brugha, Traolach S; Buchbinder, Rachelle; Buckle, Geoffrey C; Budke, Christine M; Bulchis, Anne; Bulloch, Andrew G; Campos-Nonato, Ismael R; Carabin, Hélène; Carapetis, Jonathan R; Cárdenas, Rosario; Carpenter, David O; Caso, Valeria; Castañeda-Orjuela, Carlos A; Castro, Ruben E; Catalá-López, Ferrán; Cavalleri, Fiorella; Çavlin, Alanur; Chadha, Vineet K; Chang, Jung-Chen; Charlson, Fiona J; Chen, Honglei; Chen, Wanqing; Chiang, Peggy P; Chimed-Ochir, Odgerel; Chowdhury, Rajiv; Christensen, Hanne; Christophi, Costas A; Cirillo, Massimo; Coates, Matthew M; Coffeng, Luc E; Coggeshall, Megan S; Colistro, Valentina; Colquhoun, Samantha M; Cooke, Graham S; Cooper, Cyrus; Cooper, Leslie T; Coppola, Luis M; Cortinovis, Monica; Criqui, Michael H; Crump, John A; Cuevas-Nasu, Lucia; Danawi, Hadi; Dandona, Lalit; Dandona, Rakhi; Dansereau, Emily; Dargan, Paul I; Davey, Gail; Davis, Adrian; Davitoiu, Dragos V; Dayama, Anand; De Leo, Diego; Degenhardt, Louisa; Del Pozo-Cruz, Borja; Dellavalle, Robert P; Deribe, Kebede; Derrett, Sarah; Des Jarlais, Don C; Dessalegn, Muluken; Dharmaratne, Samath D; Dherani, Mukesh K; Diaz-Torné, Cesar; Dicker, Daniel; Ding, Eric L; Dokova, Klara; Dorsey, E Ray; Driscoll, Tim R; Duan, Leilei; Duber, Herbert C; Ebel, Beth E; Edmond, Karen M; Elshrek, Yousef M; Endres, Matthias; Ermakov, Sergey P; Erskine, Holly E; Eshrati, Babak; Esteghamati, Alireza; Estep, Kara; Faraon, Emerito Jose A; Farzadfar, Farshad; Fay, Derek F; Feigin, Valery L; Felson, David T; Fereshtehnejad, Seyed-Mohammad; Fernandes, Jefferson G; Ferrari, Alize J; Fitzmaurice, Christina; Flaxman, Abraham D; Fleming, Thomas D; Foigt, Nataliya; Forouzanfar, Mohammad H; Fowkes, F Gerry R; Paleo, Urbano Fra; Franklin, Richard C; Fürst, Thomas; Gabbe, Belinda; Gaffikin, Lynne; Gankpé, Fortuné G; Geleijnse, Johanna M; Gessner, Bradford D; Gething, Peter; Gibney, Katherine B; Giroud, Maurice; Giussani, Giorgia; Gomez Dantes, Hector; Gona, Philimon; González-Medina, Diego; Gosselin, Richard A; Gotay, Carolyn C; Goto, Atsushi; Gouda, Hebe N; Graetz, Nicholas; Gugnani, Harish C; Gupta, Rahul; Gupta, Rajeev; Gutiérrez, Reyna A; Haagsma, Juanita; Hafezi-Nejad, Nima; Hagan, Holly; Halasa, Yara A; Hamadeh, Randah R; Hamavid, Hannah; Hammami, Mouhanad; Hancock, Jamie; Hankey, Graeme J; Hansen, Gillian M; Hao, Yuantao; Harb, Hilda L; Haro, Josep Maria; Havmoeller, Rasmus; Hay, Simon I; Hay, Roderick J; Heredia-Pi, Ileana B; Heuton, Kyle R; Heydarpour, Pouria; Higashi, Hideki; Hijar, Martha; Hoek, Hans W; Hoffman, Howard J; Hosgood, H Dean; Hossain, Mazeda; Hotez, Peter J; Hoy, Damian G; Hsairi, Mohamed; Hu, Guoqing; Huang, Cheng; Huang, John J; Husseini, Abdullatif; Huynh, Chantal; Iannarone, Marissa L; Iburg, Kim M; Innos, Kaire; Inoue, Manami; Islami, Farhad; Jacobsen, Kathryn H; Jarvis, Deborah L; Jassal, Simerjot K; Jee, Sun Ha; Jeemon, Panniyammakal; Jensen, Paul N; Jha, Vivekanand; Jiang, Guohong; Jiang, Ying; Jonas, Jost B; Juel, Knud; Kan, Haidong; Karch, André; Karema, Corine K; Karimkhani, Chante; Karthikeyan, Ganesan; Kassebaum, Nicholas J; Kaul, Anil; Kawakami, Norito; Kazanjan, Konstantin; Kemp, Andrew H; Kengne, Andre P; Keren, Andre; Khader, Yousef S; Khalifa, Shams Eldin A; Khan, Ejaz A; Khan, Gulfaraz; Khang, Young-Ho; Kieling, Christian; Kim, Daniel; Kim, Sungroul; Kim, Yunjin; Kinfu, Yohannes; Kinge, Jonas M; Kivipelto, Miia; Knibbs, Luke D; Knudsen, Ann Kristin; Kokubo, Yoshihiro; Kosen, Soewarta; Krishnaswami, Sanjay; Kuate Defo, Barthelemy; Kucuk Bicer, Burcu; Kuipers, Ernst J; Kulkarni, Chanda; Kulkarni, Veena S; Kumar, G Anil; Kyu, Hmwe H; Lai, Taavi; Lalloo, Ratilal; Lallukka, Tea; Lam, Hilton; Lan, Qing; Lansingh, Van C; Larsson, Anders; Lawrynowicz, Alicia E B; Leasher, Janet L; Leigh, James; Leung, Ricky; Levitz, Carly E; Li, Bin; Li, Yichong; Li, Yongmei; Lim, Stephen S; Lind, Maggie; Lipshultz, Steven E; Liu, Shiwei; Liu, Yang; Lloyd, Belinda K; Lofgren, Katherine T; Logroscino, Giancarlo; Looker, Katharine J; Lortet-Tieulent, Joannie; Lotufo, Paulo A; Lozano, Rafael; Lucas, Robyn M; Lunevicius, Raimundas; Lyons, Ronan A; Ma, Stefan; Macintyre, Michael F; Mackay, Mark T; Majdan, Marek; Malekzadeh, Reza; Marcenes, Wagner; Margolis, David J; Margono, Christopher; Marzan, Melvin B; Masci, Joseph R; Mashal, Mohammad T; Matzopoulos, Richard; Mayosi, Bongani M; Mazorodze, Tasara T; Mcgill, Neil W; Mcgrath, John J; Mckee, Martin; Mclain, Abigail; Meaney, Peter A; Medina, Catalina; Mehndiratta, Man Mohan; Mekonnen, Wubegzier; Melaku, Yohannes A; Meltzer, Michele; Memish, Ziad A; Mensah, George A; Meretoja, Atte; Mhimbira, Francis A; Micha, Renata; Miller, Ted R; Mills, Edward J; Mitchell, Philip B; Mock, Charles N; Mohamed Ibrahim, Norlinah; Mohammad, Karzan A; Mokdad, Ali H; Mola, Glen L D; Monasta, Lorenzo; Montañez Hernandez, Julio C; Montico, Marcella; Montine, Thomas J; Mooney, Meghan D; Moore, Ami R; Moradi-Lakeh, Maziar; Moran, Andrew E; Mori, Rintaro; Moschandreas, Joanna; Moturi, Wilkister N; Moyer, Madeline L; Mozaffarian, Dariush; Msemburi, William T; Mueller, Ulrich O; Mukaigawara, Mitsuru; Mullany, Erin C; Murdoch, Michele E; Murray, Joseph; Murthy, Kinnari S; Naghavi, Mohsen; Naheed, Aliya; Naidoo, Kovin S; Naldi, Luigi; Nand, Devina; Nangia, Vinay; Narayan, K M Venkat; Nejjari, Chakib; Neupane, Sudan P; Newton, Charles R; Ng, Marie; Ngalesoni, Frida N; Nguyen, Grant; Nisar, Muhammad I; Nolte, Sandra; Norheim, Ole F; Norman, Rosana E; Norrving, Bo; Nyakarahuka, Luke; Oh, In-Hwan; Ohkubo, Takayoshi; Ohno, Summer L; Olusanya, Bolajoko O; Opio, John Nelson; Ortblad, Katrina; Ortiz, Alberto; Pain, Amanda W; Pandian, Jeyaraj D; Panelo, Carlo Irwin A; Papachristou, Christina; Park, Eun-Kee; Park, Jae-Hyun; Patten, Scott B; Patton, George C; Paul, Vinod K; Pavlin, Boris I; Pearce, Neil; Pereira, David M; Perez-Padilla, Rogelio; Perez-Ruiz, Fernando; Perico, Norberto; Pervaiz, Aslam; Pesudovs, Konrad; Peterson, Carrie B; Petzold, Max; Phillips, Michael R; Phillips, Bryan K; Phillips, David E; Piel, Frédéric B; Plass, Dietrich; Poenaru, Dan; Polinder, Suzanne; Pope, Daniel; Popova, Svetlana; Poulton, Richie G; Pourmalek, Farshad; Prabhakaran, Dorairaj; Prasad, Noela M; Pullan, Rachel L; Qato, Dima M; Quistberg, D Alex; Rafay, Anwar; Rahimi, Kazem; Rahman, Sajjad U; Raju, Murugesan; Rana, Saleem M; Razavi, Homie; Reddy, K Srinath; Refaat, Amany; Remuzzi, Giuseppe; Resnikoff, Serge; Ribeiro, Antonio L; Richardson, Lee; Richardus, Jan Hendrik; Roberts, D Allen; Rojas-Rueda, David; Ronfani, Luca; Roth, Gregory A; Rothenbacher, Dietrich; Rothstein, David H; Rowley, Jane T; Roy, Nobhojit; Ruhago, George M; Saeedi, Mohammad Y; Saha, Sukanta; Sahraian, Mohammad Ali; Sampson, Uchechukwu K A; Sanabria, Juan R; Sandar, Logan; Santos, Itamar S; Satpathy, Maheswar; Sawhney, Monika; Scarborough, Peter; Schneider, Ione J; Schöttker, Ben; Schumacher, Austin E; Schwebel, David C; Scott, James G; Seedat, Soraya; Sepanlou, Sadaf G; Serina, Peter T; Servan-Mori, Edson E; Shackelford, Katya A; Shaheen, Amira; Shahraz, Saeid; Shamah Levy, Teresa; Shangguan, Siyi; She, Jun; Sheikhbahaei, Sara; Shi, Peilin; Shibuya, Kenji; Shinohara, Yukito; Shiri, Rahman; Shishani, Kawkab; Shiue, Ivy; Shrime, Mark G; Sigfusdottir, Inga D; Silberberg, Donald H; Simard, Edgar P; Sindi, Shireen; Singh, Abhishek; Singh, Jasvinder A; Singh, Lavanya; Skirbekk, Vegard; Slepak, Erica Leigh; Sliwa, Karen; Soneji, Samir; Søreide, Kjetil; Soshnikov, Sergey; Sposato, Luciano A; Sreeramareddy, Chandrashekhar T; Stanaway, Jeffrey D; Stathopoulou, Vasiliki; Stein, Dan J; Stein, Murray B; Steiner, Caitlyn; Steiner, Timothy J; Stevens, Antony; Stewart, Andrea; Stovner, Lars J; Stroumpoulis, Konstantinos; Sunguya, Bruno F; Swaminathan, Soumya; Swaroop, Mamta; Sykes, Bryan L; Tabb, Karen M; Takahashi, Ken; Tandon, Nikhil; Tanne, David; Tanner, Marcel; Tavakkoli, Mohammad; Taylor, Hugh R; Te Ao, Braden J; Tediosi, Fabrizio; Temesgen, Awoke M; Templin, Tara; Ten Have, Margreet; Tenkorang, Eric Y; Terkawi, Abdullah S; Thomson, Blake; Thorne-Lyman, Andrew L; Thrift, Amanda G; Thurston, George D; Tillmann, Taavi; Tonelli, Marcello; Topouzis, Fotis; Toyoshima, Hideaki; Traebert, Jefferson; Tran, Bach X; Trillini, Matias; Truelsen, Thomas; Tsilimbaris, Miltiadis; Tuzcu, Emin M; Uchendu, Uche S; Ukwaja, Kingsley N; Undurraga, Eduardo A; Uzun, Selen B; Van Brakel, Wim H; Van De Vijver, Steven; van Gool, Coen H; Van Os, Jim; Vasankari, Tommi J; Venketasubramanian, N; Violante, Francesco S; Vlassov, Vasiliy V; Vollset, Stein Emil; Wagner, Gregory R; Wagner, Joseph; Waller, Stephen G; Wan, Xia; Wang, Haidong; Wang, Jianli; Wang, Linhong; Warouw, Tati S; Weichenthal, Scott; Weiderpass, Elisabete; Weintraub, Robert G; Wenzhi, Wang; Werdecker, Andrea; Westerman, Ronny; Whiteford, Harvey A; Wilkinson, James D; Williams, Thomas N; Wolfe, Charles D; Wolock, Timothy M; Woolf, Anthony D; Wulf, Sarah; Wurtz, Brittany; Xu, Gelin; Yan, Lijing L; Yano, Yuichiro; Ye, Pengpeng; Yentür, Gökalp K; Yip, Paul; Yonemoto, Naohiro; Yoon, Seok-Jun; Younis, Mustafa Z; Yu, Chuanhua; Zaki, Maysaa E; Zhao, Yong; Zheng, Yingfeng; Zonies, David; Zou, Xiaonong; Salomon, Joshua A; Lopez, Alan D; Vos, Theo

    2015-11-28

    The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4

  12. Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system.

    PubMed

    Tsuruta, James K; Dayton, Paul A; Gallippi, Caterina M; O'Rand, Michael G; Streicker, Michael A; Gessner, Ryan C; Gregory, Thomas S; Silva, Erick J R; Hamil, Katherine G; Moser, Glenda J; Sokal, David C

    2012-01-30

    Studies published in the 1970s by Mostafa S. Fahim and colleagues showed that a short treatment with ultrasound caused the depletion of germ cells and infertility. The goal of the current study was to determine if a commercially available therapeutic ultrasound generator and transducer could be used as the basis for a male contraceptive. Sprague-Dawley rats were anesthetized and their testes were treated with 1 MHz or 3 MHz ultrasound while varying power, duration and temperature of treatment. We found that 3 MHz ultrasound delivered with 2.2 Watt per square cm power for fifteen minutes was necessary to deplete spermatocytes and spermatids from the testis and that this treatment significantly reduced epididymal sperm reserves. 3 MHz ultrasound treatment reduced total epididymal sperm count 10-fold lower than the wet-heat control and decreased motile sperm counts 1,000-fold lower than wet-heat alone. The current treatment regimen provided nominally more energy to the treatment chamber than Fahim's originally reported conditions of 1 MHz ultrasound delivered at 1 Watt per square cm for ten minutes. However, the true spatial average intensity, effective radiating area and power output of the transducers used by Fahim were not reported, making a direct comparison impossible. We found that germ cell depletion was most uniform and effective when we rotated the therapeutic transducer to mitigate non-uniformity of the beam field. The lowest sperm count was achieved when the coupling medium (3% saline) was held at 37 degrees C and two consecutive 15-minute treatments of 3 MHz ultrasound at 2.2 Watt per square cm were separated by 2 days. The non-invasive nature of ultrasound and its efficacy in reducing sperm count make therapeutic ultrasound a promising candidate for a male contraceptive. However, further studies must be conducted to confirm its efficacy in providing a contraceptive effect, to test the result of repeated use, to verify that the contraceptive effect is

  13. Too Depleted to Try? Testing the Process Model of Ego Depletion in the Context of Unhealthy Snack Consumption.

    PubMed

    Haynes, Ashleigh; Kemps, Eva; Moffitt, Robyn

    2016-11-01

    The process model proposes that the ego depletion effect is due to (a) an increase in motivation toward indulgence, and (b) a decrease in motivation to control behaviour following an initial act of self-control. In contrast, the reflective-impulsive model predicts that ego depletion results in behaviour that is more consistent with desires, and less consistent with motivations, rather than influencing the strength of desires and motivations. The current study sought to test these alternative accounts of the relationships between ego depletion, motivation, desire, and self-control. One hundred and fifty-six undergraduate women were randomised to complete a depleting e-crossing task or a non-depleting task, followed by a lab-based measure of snack intake, and self-report measures of motivation and desire strength. In partial support of the process model, ego depletion was related to higher intake, but only indirectly via the influence of lowered motivation. Motivation was more strongly predictive of intake for those in the non-depletion condition, providing partial support for the reflective-impulsive model. Ego depletion did not affect desire, nor did depletion moderate the effect of desire on intake, indicating that desire may be an appropriate target for reducing unhealthy behaviour across situations where self-control resources vary. © 2016 The International Association of Applied Psychology.

  14. Coma Morphology Due to an Extended Active Region and Implications for the Spin State of Comet Hale-Bopp

    NASA Technical Reports Server (NTRS)

    Samarasinha, Nalin H.

    2000-01-01

    We show that the circular character of continuum structures observed in the coma of comet Hale-Bopp around the perihelion passage is most likely due to a dust jet from a large extended active region on the surface. Coma morphology due to a wide jet is different from that due to a narrow jet. The latter shows foreshortening effects due to observing geometry, wider jet produces more circular features. This circularization effect provides a self-consistent explanation for the evolution of near-perihelion coma morphology. No changes in the direction of the rotational angular momentum vector are required during this period in contrast to the models of Schleicher et al. This circularization effect also enables us to produce near-circular coma features in the S-E quadrant during 1997 late February and therefore questions the basic premise on which Sekanina bases his morphological arguments for a gravitationally bound satellite nucleus.

  15. Atmospheric Tracer Depletion Testing for Unfiltered Air In-Leakage Determination at the Wolf Creek Nuclear Power Plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sullivan, T. M.; Wilke, R. J.; Roberts, T.

    Atmospheric Tracer Depletion tests were conducted at the Wolf Creek Nuclear Power Plant to quantify the unfiltered in-leakage (UI) into the Control Room (CR), Control Building (CB), and Equipment Rooms (ER) at the Wolf Creek Nuclear Power Plant. Wolf Creek has two independent charcoal filter Emergency Ventilation Systems (EVS) that can be used to purify air entering the control building and control room. The Bravo System contains a filtration system in Room 1501 in the Auxiliary Building for the Control Room and another filtration system (FGK02B) on Elevation 2016 for the Control Building. The Alpha system contains a filtration systemmore » in Room 1512 in the Auxiliary Building for the Control Room and another filtration system (FGK02A) on Elevation 2016 for the Control Building. The Atmospheric Tracer Depletion (ATD) test is a technique to measure in-leakage using the concentration of perfluorocarbon compounds that have a constant atmospheric background. These levels are present in the Control Room and Control Building under normal operating conditions. When air is supplied by either of the EVS, most of the PFTS are removed by the charcoal filters. If the concentrations of the PFTs measured in protected areas are the same as the levels at the output of the EVS, the in-leakage of outside air into the protected area would be zero. If the concentration is higher in the protected area than at the output of the filter system, there is in-leakage and the in-leakage can be quantified by the difference. Sampling was performed using state-of-the-art Brookhaven Atmospheric Tracer Samplers (BATS) air sampling equipment and analysis performed on Brookhaven National Laboratory (BNL) dedicated PFT analytical systems. In the Alpha test two tracers PMCH and mcPDCH were used to determine in-leakage into the control building. The analytical system was tuned to maximize sensitivity after initial analysis of the Alpha test. The increased sensitivity permitted accurate

  16. Atmospheric Tracer Depletion Testing for Unfiltered Air In-Leakage Determination at the Wolf Creek Nuclear Power Plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sullivan, T. M.; Wilke, R. J.; Roberts, T.

    Atmospheric Tracer Depletion tests were conducted at the Wolf Creek Nuclear Power Plant to quantify the unfiltered in-leakage (UI) into the Control Room (CR), Control Building (CB), and Equipment Rooms (ER) at the Wolf Creek Nuclear Power Plant. Wolf Creek has two independent charcoal filter Emergency Ventilation Systems (EVS) that can be used to purify air entering the control building and control room. The Bravo System contains a filtration system in Room 1501 in the Auxiliary Building for the Control Room and another filtration system (FGK02B) on Elevation 2016 for the Control Building. The Alpha system contains a filtration systemmore » in Room 1512 in the Auxiliary Building for the Control Room and another filtration system (FGK02A) on Elevation 2016 for the Control Building.The Atmospheric Tracer Depletion (ATD) test is a technique to measure in-leakage using the concentration of perfluorocarbon compounds that have a constant atmospheric background. These levels are present in the Control Room and Control Building under normal operating conditions. When air is supplied by either of the EVS, most of the PFTS are removed by the charcoal filters. If the concentrations of the PFTs measured in protected areas are the same as the levels at the output of the EVS, the in-leakage of outside air into the protected area would be zero. If the concentration is higher in the protected area than at the output of the filter system, there is in-leakage and the in-leakage can be quantified by the difference.Sampling was performed using state-of-the-art Brookhaven Atmospheric Tracer Samplers (BATS) air sampling equipment and analysis performed on Brookhaven National Laboratory (BNL) dedicated PFT analytical systems. In the Alpha test two tracers PMCH and mcPDCH were used to determine in-leakage into the control building. The analytical system was tuned to maximize sensitivity after initial analysis of the Alpha test. The increased sensitivity permitted accurate quantification

  17. VizieR Online Data Catalog: Revised source list for the Rees 38-MHz survey (Hales+ 1995)

    NASA Astrophysics Data System (ADS)

    Hales, S. E. G.; Waldram, E. M.; Rees, N.; Warner, P. J.

    1994-11-01

    We present a revised machine-readable source list for the Rees 38-MHz (or '8C') survey with improved positions and no redundancy. The Rees 38-MHz survey covers an area of about 1 sr north of declination +60 degrees. The angular resolution is 4.5 x 4.5cosec(Dec) arcmin**2 and the limiting flux density over much of the survey area is about 1 Jy. Both of these figures are an improvement by nearly an order of magnitude on previous surveys at this frequency. Users of these data should consult and cite the original survey paper by Rees as primary reference (1990MNRAS.244..233R) with the present publication (1995MNRAS.274..447H) as a supplementary revision. The recommended style of reference is thus : "The revised Rees 38-MHz survey (Rees 1990, catalogue revised Hales et. al 1995)." Note that for interest the source list includes data on some sources at declinations lower than +60 degrees, but that the right ascension coverage is not complete below +60 degrees. (1 data file).

  18. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition

    PubMed Central

    2015-01-01

    Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age–sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. Methods We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. Findings Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6–6·6), from 65·3 years (65·0–65·6) in 1990 to 71·5 years (71·0–71·9) in 2013, HALE at birth rose by 5·4 years (4·9–5·8), from 56·9 years (54·5–59·1) to 62·3 years (59·7

  19. Ir Observations Of An Outburst In Comet Hale-Bopp (C/1995 O1)

    NASA Astrophysics Data System (ADS)

    Tozzi, Gian Paolo; Mannucci, Filippo; Stanga, Ruggero

    1997-07-01

    The comet Hale-Bopp (C/1995 O1) has been observed in the infrared (1 2.5 μm) with the Nordic Optical Telescope (NOT) equipped with the Arcetri NICMOS3 camera (ARNICA). Two observational campaigns, each one lasting about one week, were made when the comet heliocentric distance was about 3 AU. The first campaign was at the end of August and the second at the end of September 1996. During both runs two major outbursts were observed, the more intense of them started the day before the beginning of the second run. In the images recorded during the first three nights (24.8 26.8 Sept.) of the second run a dust shell expanding in the northern quadrant with a projected velocity of 0.14 0.28 km/s is clearly evident. The dust production rate increased by at least a factor ≈3 at the time of the outburst. Also evident on the first night is a change in the IR color that is well correlated with the dust shell. This is an indication that the material released by the outburst has a different composition and/or size distribution than that in the “quiescent” dust coma. In this paper we present preliminary results about the evolution and the photometric characteristics of the dust shell.

  20. Passive morphing of flying wing aircraft: Z-shaped configuration

    NASA Astrophysics Data System (ADS)

    Mardanpour, Pezhman; Hodges, Dewey H.

    2014-01-01

    High Altitude, Long Endurance (HALE) aircraft can achieve sustained, uninterrupted flight time if they use solar power. Wing morphing of solar powered HALE aircraft can significantly increase solar energy absorbency. An example of the kind of morphing considered in this paper requires the wings to fold so as to orient a solar panel to be hit more directly by the sun's rays at specific times of the day. An example of the kind of morphing considered in this paper requires the wings to fold so as to orient a solar panel that increases the absorption of solar energy by decreasing the angle of incidence of the solar radiation at specific times of the day. In this paper solar powered HALE flying wing aircraft are modeled with three beams with lockable hinge connections. Such aircraft are shown to be capable of morphing passively, following the sun by means of aerodynamic forces and engine thrusts. The analysis underlying NATASHA (Nonlinear Aeroelastic Trim And Stability of HALE Aircraft), a computer program that is based on geometrically exact, fully intrinsic beam equations and a finite-state induced flow model, was extended to include the ability to simulate morphing of the aircraft into a "Z" configuration. Because of the "long endurance" feature of HALE aircraft, such morphing needs to be done without relying on actuators and at as near zero energy cost as possible. The emphasis of this study is to substantially demonstrate the processes required to passively morph a flying wing into a Z-shaped configuration and back again.

  1. Effects of Macrophage Depletion on Sleep in Mice

    PubMed Central

    Ames, Conner; Boland, Erin; Szentirmai, Éva

    2016-01-01

    The reciprocal interaction between the immune system and sleep regulation has been widely acknowledged but the cellular mechanisms that underpin this interaction are not completely understood. In the present study, we investigated the role of macrophages in sleep loss- and cold exposure-induced sleep and body temperature responses. Macrophage apoptosis was induced in mice by systemic injection of clodronate-containing liposomes (CCL). We report that CCL treatment induced an immediate and transient increase in non-rapid-eye movement sleep (NREMS) and fever accompanied by decrease in rapid-eye movement sleep, motor activity and NREMS delta power. Chronically macrophage-depleted mice had attenuated NREMS rebound after sleep deprivation compared to normal mice. Cold-induced increase in wakefulness and decrease in NREMS, rapid-eye movement sleep and body temperature were significantly enhanced in macrophage-depleted mice indicating increased cold sensitivity. These findings provide further evidence for the reciprocal interaction among the immune system, sleep and metabolism, and identify macrophages as one of the key cellular elements in this interplay. PMID:27442442

  2. Gadolinia depletion analysis by CASMO-4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kobayashi, Y.; Saji, E.; Toba, A.

    1993-01-01

    CASMO-4 is the most recent version of the lattice physics code CASMO introduced by Studsvik. The principal aspects of the CASMO-4 model that differ from the models in previous CASMO versions are as follows: (1) heterogeneous model for two-dimensional transport theory calculations; and (2) microregion depletion model for burnable absorbers, such as gadolinia. Of these aspects, the first has previously been benchmarked against measured data of critical experiments and Monte Carlo calculations, verifying the high degree of accuracy. To proceed with CASMO-4 benchmarking, it is desirable to benchmark the microregion depletion model, which enables CASMO-4 to calculate gadolinium depletion directlymore » without the need for precalculated MICBURN cross-section data. This paper presents the benchmarking results for the microregion depletion model in CASMO-4 using the measured data of depleted gadolinium rods.« less

  3. Simulations and observations of plasma depletion, ion composition, and airglow emissions in two auroral ionospheric depletion experiments

    NASA Technical Reports Server (NTRS)

    Yau, A. W.; Whalen, B. A.; Harris, F. R.; Gattinger, R. L.; Pongratz, M. B.

    1985-01-01

    Observations of plasma depletion, ion composition modification, and airglow emissions in the Waterhole experiments are presented. The detailed ion chemistry and airglow emission processes related to the ionospheric hole formation in the experiment are examined, and observations are compared with computer simulation results. The latter indicate that the overall depletion rates in different parts of the depletion region are governed by different parameters.

  4. Depletion of the vibrational ground state of CH4 in absorption spectroscopy at 3.4 μm in N2 and air in the 1-100 Torr range

    NASA Astrophysics Data System (ADS)

    Hausmaninger, Thomas; Zhao, Gang; Ma, Weiguang; Axner, Ove

    2018-01-01

    A model presented in an accompanying work predicts that mid-IR absorption signals from methane in trace concentrations in various buffer gases detected at pressures in the 1-100 Torr range can be reduced and distorted due to depletion of the vibrational ground state if the molecules are exposed to laser powers in the tens of mW range or above. This work provides experimental evidence of such depletion in a resonant cavity under a variety of conditions, e.g. for intracavity laser powers up to 2 W and for buffer gases of N2 or dry air, and verifies the applicability of the model. It was found that the degree of depletion is significantly larger in N2 than dry air, and that it increases with pressure for pressures up to around 10 Torr (attributed to a decreased diffusion rate) but decreases with pressure for pressures above 20 Torr (caused by an increased collisional vibrational decay rate). The maximum degree of depletion (∼80%) was obtained for methane in N2 at around 15 Torr. This implies that absorption spectrometry of methane can experience significant non-linear dependencies on laser power, pressure, as well as buffer gas composition. It is shown that depletion takes place also in 13CH4, which verifies the applicability of the model also for this isotopologue, and that NICE-OHMS signals detected in absorption phase are less affected by depletion than in dispersion. It was concluded that the absorption mode of detection can provide concentration assessments that are virtually free of influence of depletion for intracavity powers below 0.8 W.

  5. Standardization of formulations for the acute amino acid depletion and loading test

    PubMed Central

    Badawy, Abdulla A-B; Dougherty, Donald M

    2017-01-01

    The acute tryptophan (Trp) depletion (ATD) and loading (ATL) and the acute tyrosine (Tyr) plus phenylalanine (Phe) depletion (ATPD) tests are powerful tools for studying the roles of cerebral monoamines in behaviour and symptoms related to various disorders. The tests use either amino acid mixtures or proteins. Current amino acid mixtures lack specificity in humans, but not in rodents, because of the faster disposal of branched-chain amino acids (BCAA) by the latter. The high content of BCAA (30-60%) is responsible for the poor specificity in humans and we recommend, in a 50g dose, the control formulation of Young et al. (1985) with a lowered BCAA content (18%) and minor modifications as a common control for the above tests. With protein-based formulations, α-lactalbumin is specific for ATL, whereas gelatine is only partially effective for ATD. We recommend the use of the whey protein fraction glycomacropeptide (GMP) as an alternative protein. Its BCAA content is ideal for specificity and the absence of Trp, Tyr and Phe render it suitable as a template for 7 formulations (separate and combined depletion or loading and a truly balanced control). We invite the research community to participate in standardization of the depletion and loading methodologies by using our recommended amino acid formulation and developing those based on GMP. PMID:25586395

  6. 48 CFR 52.223-11 - Ozone-Depleting Substances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Ozone-Depleting Substances....223-11 Ozone-Depleting Substances. As prescribed in 23.804(a), insert the following clause: Ozone-Depleting Substances (MAY 2001) (a) Definition. Ozone-depleting substance, as used in this clause, means any...

  7. 48 CFR 52.223-11 - Ozone-Depleting Substances.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Ozone-Depleting Substances....223-11 Ozone-Depleting Substances. As prescribed in 23.804(a), insert the following clause: Ozone-Depleting Substances (MAY 2001) (a) Definition. Ozone-depleting substance, as used in this clause, means any...

  8. 48 CFR 52.223-11 - Ozone-Depleting Substances.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Ozone-Depleting Substances....223-11 Ozone-Depleting Substances. As prescribed in 23.804(a), insert the following clause: Ozone-Depleting Substances (MAY 2001) (a) Definition. Ozone-depleting substance, as used in this clause, means any...

  9. 48 CFR 52.223-11 - Ozone-Depleting Substances.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Ozone-Depleting Substances....223-11 Ozone-Depleting Substances. As prescribed in 23.804(a), insert the following clause: Ozone-Depleting Substances (MAY 2001) (a) Definition. Ozone-depleting substance, as used in this clause, means any...

  10. 48 CFR 52.223-11 - Ozone-Depleting Substances.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Ozone-Depleting Substances....223-11 Ozone-Depleting Substances. As prescribed in 23.804(a), insert the following clause: Ozone-Depleting Substances (MAY 2001) (a) Definition. Ozone-depleting substance, as used in this clause, means any...

  11. Time-on-task effects in children with and without ADHD: depletion of executive resources or depletion of motivation?

    PubMed

    Dekkers, Tycho J; Agelink van Rentergem, Joost A; Koole, Alette; van den Wildenberg, Wery P M; Popma, Arne; Bexkens, Anika; Stoffelsen, Reino; Diekmann, Anouk; Huizenga, Hilde M

    2017-12-01

    Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by deficits in their executive functioning and motivation. In addition, these children are characterized by a decline in performance as time-on-task increases (i.e., time-on-task effects). However, it is unknown whether these time-on-task effects should be attributed to deficits in executive functioning or to deficits in motivation. Some studies in typically developing (TD) adults indicated that time-on-task effects should be interpreted as depletion of executive resources, but other studies suggested that they represent depletion of motivation. We, therefore, investigated, in children with and without ADHD, whether there were time-on-task effects on executive functions, such as inhibition and (in)attention, and whether these were best explained by depletion of executive resources or depletion of motivation. The stop-signal task (SST), which generates both indices of inhibition (stop-signal reaction time) and attention (reaction time variability and errors), was administered in 96 children (42 ADHD, 54 TD controls; aged 9-13). To differentiate between depletion of resources and depletion of motivation, the SST was administered twice. Half of the participants was reinforced during second task performance, potentially counteracting depletion of motivation. Multilevel analyses indicated that children with ADHD were more affected by time-on-task than controls on two measures of inattention, but not on inhibition. In the ADHD group, reinforcement only improved performance on one index of attention (i.e., reaction time variability). The current findings suggest that time-on-task effects in children with ADHD occur specifically in the attentional domain, and seem to originate in both depletion of executive resources and depletion of motivation. Clinical implications for diagnostics, psycho-education, and intervention are discussed.

  12. Coordinated Observations of Comet Hale-Bopp between 32 and 860 GHz

    NASA Astrophysics Data System (ADS)

    Wink, J. E.; Altenhoff, W. J.; Bieging, J.; Butler, B.; Butner, H.; Haslam, C. G. T.; Kreysa, E.; Martin, R.; Mauersberger, R.; McMullin, J.; Muders, D.; Peters, W.; Schmidt, J.; Schraml, J. B.; Sievers, A.; Stumpff, P.; von Kapp-Herr, A.; Thum, C.; Zylka, R.

    1997-05-01

    The concept of simultaneous multifrequency continuum observations, successfully tested on Comet Hyakutake, was applied to Comet Hale-Bopp, using the Heinrich Hertz Submillimeter Telescope (HHT) with the four color bolometer between 250 and 870 GHz, the IRAM 30m telescope at 240 Ghz, the MPIfR 100-m telescope at 32 GHz, and the IRAM interferometer near 90 and 240 GHz. Near-simultaneous measurements were done between February 15 and April 26, 1997, mainly concentrated in mid March shortly before perigee of the comet. The measurements gave the following preliminary results: Interferometer detection of the nuclear thermal emission. If the signal at the longest interferometer spacing of 170 m is due to thermal emission from the nucleus only, its equivalent diameter is ~49 km. If, however, this signal contains a contribution from a strongly centrally peaked halo distribution (e.g., r^-2 density variation) the diameter may be as low as 35 km. The emission found interferometrically was always 5arcsec north and 0.1 sec east from the position predicted by Yeoman's solution 55. The comparison of the interferometric continuum emission with the simultanously obtained molecular line observations (reported on this conference) shows the origin of the strongest line emission concentrated on the nucleus. The 30-m observations show a radio halo with a gaussian FWHP of ~11, corresponding to a diameter of 11000 km at geocentric distance of 1.2 a.u. A spectral index of ~3.0 for the total signal, which may indicate a smaller mean particle size than for Hyakutake. Assuming an average cometary density of 0.5 gcm^-3, the mass contained in the nucleus is ~1-3 10^19 g and 10^12 g in the particle halo.

  13. Streamflow depletion by wells--Understanding and managing the effects of groundwater pumping on streamflow

    USGS Publications Warehouse

    Barlow, Paul M.; Leake, Stanley A.

    2012-11-02

    Groundwater is an important source of water for many human needs, including public supply, agriculture, and industry. With the development of any natural resource, however, adverse consequences may be associated with its use. One of the primary concerns related to the development of groundwater resources is the effect of groundwater pumping on streamflow. Groundwater and surface-water systems are connected, and groundwater discharge is often a substantial component of the total flow of a stream. Groundwater pumping reduces the amount of groundwater that flows to streams and, in some cases, can draw streamflow into the underlying groundwater system. Streamflow reductions (or depletions) caused by pumping have become an important water-resource management issue because of the negative impacts that reduced flows can have on aquatic ecosystems, the availability of surface water, and the quality and aesthetic value of streams and rivers. Scientific research over the past seven decades has made important contributions to the basic understanding of the processes and factors that affect streamflow depletion by wells. Moreover, advances in methods for simulating groundwater systems with computer models provide powerful tools for estimating the rates, locations, and timing of streamflow depletion in response to groundwater pumping and for evaluating alternative approaches for managing streamflow depletion. The primary objective of this report is to summarize these scientific insights and to describe the various field methods and modeling approaches that can be used to understand and manage streamflow depletion. A secondary objective is to highlight several misconceptions concerning streamflow depletion and to explain why these misconceptions are incorrect.

  14. New Approach For Prediction Groundwater Depletion

    NASA Astrophysics Data System (ADS)

    Moustafa, Mahmoud

    2017-01-01

    Current approaches to quantify groundwater depletion involve water balance and satellite gravity. However, the water balance technique includes uncertain estimation of parameters such as evapotranspiration and runoff. The satellite method consumes time and effort. The work reported in this paper proposes using failure theory in a novel way to predict groundwater saturated thickness depletion. An important issue in the failure theory proposed is to determine the failure point (depletion case). The proposed technique uses depth of water as the net result of recharge/discharge processes in the aquifer to calculate remaining saturated thickness resulting from the applied pumping rates in an area to evaluate the groundwater depletion. Two parameters, the Weibull function and Bayes analysis were used to model and analyze collected data from 1962 to 2009. The proposed methodology was tested in a nonrenewable aquifer, with no recharge. Consequently, the continuous decline in water depth has been the main criterion used to estimate the depletion. The value of the proposed approach is to predict the probable effect of the current applied pumping rates on the saturated thickness based on the remaining saturated thickness data. The limitation of the suggested approach is that it assumes the applied management practices are constant during the prediction period. The study predicted that after 300 years there would be an 80% probability of the saturated aquifer which would be expected to be depleted. Lifetime or failure theory can give a simple alternative way to predict the remaining saturated thickness depletion with no time-consuming processes such as the sophisticated software required.

  15. Failure to replicate depletion of self-control.

    PubMed

    Xu, Xiaomeng; Demos, Kathryn E; Leahey, Tricia M; Hart, Chantelle N; Trautvetter, Jennifer; Coward, Pamela; Middleton, Kathryn R; Wing, Rena R

    2014-01-01

    The limited resource or strength model of self-control posits that the use of self-regulatory resources leads to depletion and poorer performance on subsequent self-control tasks. We conducted four studies (two with community samples, two with young adult samples) utilizing a frequently used depletion procedure (crossing out letters protocol) and the two most frequently used dependent measures of self-control (handgrip perseverance and modified Stroop). In each study, participants completed a baseline self-control measure, a depletion or control task (randomized), and then the same measure of self-control a second time. There was no evidence for significant depletion effects in any of these four studies. The null results obtained in four attempts to replicate using strong methodological approaches may indicate that depletion has more limited effects than implied by prior publications. We encourage further efforts to replicate depletion (particularly among community samples) with full disclosure of positive and negative results.

  16. Podocyte Depletion in Thin GBM and Alport Syndrome.

    PubMed

    Wickman, Larysa; Hodgin, Jeffrey B; Wang, Su Q; Afshinnia, Farsad; Kershaw, David; Wiggins, Roger C

    2016-01-01

    The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in urine is increased in AS, suggesting that podocyte depletion could play a role in causing progressive loss of kidney function. To test this hypothesis podometric parameters were measured in 26 kidney biopsies from 21 patients aged 2-17 years with a clinic-pathologic diagnosis including both classic Alport Syndrome with thin and thick GBM segments and lamellated lamina densa [n = 15] and Thin GBM cases [n = 6]. Protocol biopsies from deceased donor kidneys were used as age-matched controls. Podocyte depletion was present in AS biopsies prior to detectable histologic abnormalities. No abnormality was detected by light microscopy at <30% podocyte depletion, minor pathologic changes (mesangial expansion and adhesions to Bowman's capsule) were present at 30-50% podocyte depletion, and FSGS was progressively present above 50% podocyte depletion. eGFR did not change measurably until >70% podocyte depletion. Low level proteinuria was an early event at about 25% podocyte depletion and increased in proportion to podocyte depletion. These quantitative data parallel those from model systems where podocyte depletion is the causative event. This result supports a hypothesis that in AS podocyte adherence to the GBM is defective resulting in accelerated podocyte detachment causing progressive podocyte depletion leading to FSGS-like pathologic changes and eventual End Stage Kidney Disease. Early intervention to reduce podocyte depletion is projected to prolong kidney survival in AS.

  17. Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC.

    PubMed

    Kim-Wanner, Soo-Zin; Bug, Gesine; Steinmann, Juliane; Ajib, Salem; Sorg, Nadine; Poppe, Carolin; Bunos, Milica; Wingenfeld, Eva; Hümmer, Christiane; Luxembourg, Beate; Seifried, Erhard; Bonig, Halvard

    2017-08-11

    Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, "BMC", was previously introduced. We here report the largest series to date of routine quality data after performing 50 clinical-scale RBC-depletions. Fifty successive RBC-depletions from autologous (n = 5) and allogeneic (n = 45) BM transplants were performed with the Spectra Optia BMC apheresis suite. Product quality was assessed before and after processing for volume, RBC and leukocyte content; RBC-depletion and stem cell (CD34+ cells) recovery was calculated there from. Clinical engraftment data were collected from 26/45 allogeneic recipients. Median RBC removal was 98.2% (range 90.8-99.1%), median CD34+ cell recovery was 93.6%, minimum recovery being 72%, total product volume was reduced to 7.5% (range 4.7-23.0%). Products engrafted with expected probability and kinetics. Performance indicators were stable over time. Spectra Optia BMC is a robust and efficient technology for RBC-depletion and volume reduction of BM, providing near-complete RBC removal and excellent CD34+ cell recovery.

  18. Special Issue: Planar Fully-Depleted SOI technology

    NASA Astrophysics Data System (ADS)

    Allibert, F.; Hiramoto, T.; Nguyen, B. Y.

    2016-03-01

    We are in the era of mobile computing with smart handheld devices and remote data storage "in the cloud," with devices that are almost always on and driven by needs of high data transmission rate, instant access/connection and long battery life. With all the ambitious requirements for better performance with lower power consumption, the SoC solution must also be cost-effective in order to capture the large, highly-competitive consumer mobile and wearable markets. The Fully-Depleted SOI device/circuit is a unique option that can satisfy all these requirements and has made tremendous progress in development for various applications and adoption by foundries, integrated device manufacturers (IDM), and fabless companies in the last 3 years.

  19. Revisiting Antarctic Ozone Depletion

    NASA Astrophysics Data System (ADS)

    Grooß, Jens-Uwe; Tritscher, Ines; Müller, Rolf

    2015-04-01

    Antarctic ozone depletion is known for almost three decades and it has been well settled that it is caused by chlorine catalysed ozone depletion inside the polar vortex. However, there are still some details, which need to be clarified. In particular, there is a current debate on the relative importance of liquid aerosol and crystalline NAT and ice particles for chlorine activation. Particles have a threefold impact on polar chlorine chemistry, temporary removal of HNO3 from the gas-phase (uptake), permanent removal of HNO3 from the atmosphere (denitrification), and chlorine activation through heterogeneous reactions. We have performed simulations with the Chemical Lagrangian Model of the Stratosphere (CLaMS) employing a recently developed algorithm for saturation-dependent NAT nucleation for the Antarctic winters 2011 and 2012. The simulation results are compared with different satellite observations. With the help of these simulations, we investigate the role of the different processes responsible for chlorine activation and ozone depletion. Especially the sensitivity with respect to the particle type has been investigated. If temperatures are artificially forced to only allow cold binary liquid aerosol, the simulation still shows significant chlorine activation and ozone depletion. The results of the 3-D Chemical Transport Model CLaMS simulations differ from purely Lagrangian longtime trajectory box model simulations which indicates the importance of mixing processes.

  20. Transient Treg depletion enhances therapeutic anti-cancer vaccination.

    PubMed

    Fisher, Scott A; Aston, Wayne J; Chee, Jonathan; Khong, Andrea; Cleaver, Amanda L; Solin, Jessica N; Ma, Shaokang; Lesterhuis, W Joost; Dick, Ian; Holt, Robert A; Creaney, Jenette; Boon, Louis; Robinson, Bruce; Lake, Richard A

    2017-03-01

    Regulatory T cells (Treg) play an important role in suppressing anti- immunity and their depletion has been linked to improved outcomes. To better understand the role of Treg in limiting the efficacy of anti-cancer immunity, we used a Diphtheria toxin (DTX) transgenic mouse model to specifically target and deplete Treg. Tumor bearing BALB/c FoxP3.dtr transgenic mice were subjected to different treatment protocols, with or without Treg depletion and tumor growth and survival monitored. DTX specifically depleted Treg in a transient, dose-dependent manner. Treg depletion correlated with delayed tumor growth, increased effector T cell (Teff) activation, and enhanced survival in a range of solid tumors. Tumor regression was dependent on Teffs as depletion of both CD4 and CD8 T cells completely abrogated any survival benefit. Severe morbidity following Treg depletion was only observed, when consecutive doses of DTX were given during peak CD8 T cell activation, demonstrating that Treg can be depleted on multiple occasions, but only when CD8 T cell activation has returned to base line levels. Finally, we show that even minimal Treg depletion is sufficient to significantly improve the efficacy of tumor-peptide vaccination. BALB/c.FoxP3.dtr mice are an ideal model to investigate the full therapeutic potential of Treg depletion to boost anti-tumor immunity. DTX-mediated Treg depletion is transient, dose-dependent, and leads to strong anti-tumor immunity and complete tumor regression at high doses, while enhancing the efficacy of tumor-specific vaccination at low doses. Together this data highlight the importance of Treg manipulation as a useful strategy for enhancing current and future cancer immunotherapies.

  1. Physiological implications of anthropogenic environmental calcium depletion

    Treesearch

    Catherine H. Borer; Paul G. Schaberg; Donald H. DeHayes; Gary J. Hawley

    2001-01-01

    Recent evidence indicates that numerous anthropogenic factors can deplete calcium (Ca) from forested ecosystems. Although it is difficult to quantify the extent of this depletion, some reports indicate that the magnitude of Ca losses may be substantial. The potential for Ca depletion raises important questions about tree health. Only a fraction of foliar Ca is...

  2. A new definition of maternal depletion syndrome.

    PubMed Central

    Winkvist, A; Rasmussen, K M; Habicht, J P

    1992-01-01

    BACKGROUND. Although the term "maternal depletion syndrome" has been commonly used to explain poor maternal and infant health, whether such a syndrome actually exists remains unclear. This uncertainty may be due to the lack of a clear definition of the syndrome and the absence of theoretical frameworks that account for the many factors related to reproductive nutrition. METHODS. We propose a new definition of maternal depletion syndrome within a framework that accounts for potential confounding factors. RESULTS. Our conceptual framework distinguishes between childbearing pattern and inadequate diet as causes of poor maternal health; hence, our definition of maternal depletion syndrome has both biological and practical meaning. The new definition is based on overall change in maternal nutritional status over one reproductive cycle in relation to possible depletion and repletion phases and in relation to initial nutritional status. CONCLUSIONS. The empirical application of this approach should permit the testing of the existence of maternal depletion syndrome in the developing world, and the distinction between populations where family planning will alleviate maternal depletion and those in which an improved diet is also necessary. PMID:1566948

  3. ANATOMY OF DEPLETED INTERPLANETARY CORONAL MASS EJECTIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kocher, M.; Lepri, S. T.; Landi, E.

    We report a subset of interplanetary coronal mass ejections (ICMEs) containing distinct periods of anomalous heavy-ion charge state composition and peculiar ion thermal properties measured by ACE /SWICS from 1998 to 2011. We label them “depleted ICMEs,” identified by the presence of intervals where C{sup 6+}/C{sup 5+} and O{sup 7+}/O{sup 6+} depart from the direct correlation expected after their freeze-in heights. These anomalous intervals within the depleted ICMEs are referred to as “Depletion Regions.” We find that a depleted ICME would be indistinguishable from all other ICMEs in the absence of the Depletion Region, which has the defining property ofmore » significantly low abundances of fully charged species of helium, carbon, oxygen, and nitrogen. Similar anomalies in the slow solar wind were discussed by Zhao et al. We explore two possibilities for the source of the Depletion Region associated with magnetic reconnection in the tail of a CME, using CME simulations of the evolution of two Earth-bound CMEs described by Manchester et al.« less

  4. Transient Treg depletion enhances therapeutic anti‐cancer vaccination

    PubMed Central

    Aston, Wayne J.; Chee, Jonathan; Khong, Andrea; Cleaver, Amanda L.; Solin, Jessica N.; Ma, Shaokang; Lesterhuis, W. Joost; Dick, Ian; Holt, Robert A.; Creaney, Jenette; Boon, Louis; Robinson, Bruce; Lake, Richard A.

    2016-01-01

    Abstract Introduction Regulatory T cells (Treg) play an important role in suppressing anti‐ immunity and their depletion has been linked to improved outcomes. To better understand the role of Treg in limiting the efficacy of anti‐cancer immunity, we used a Diphtheria toxin (DTX) transgenic mouse model to specifically target and deplete Treg. Methods Tumor bearing BALB/c FoxP3.dtr transgenic mice were subjected to different treatment protocols, with or without Treg depletion and tumor growth and survival monitored. Results DTX specifically depleted Treg in a transient, dose‐dependent manner. Treg depletion correlated with delayed tumor growth, increased effector T cell (Teff) activation, and enhanced survival in a range of solid tumors. Tumor regression was dependent on Teffs as depletion of both CD4 and CD8 T cells completely abrogated any survival benefit. Severe morbidity following Treg depletion was only observed, when consecutive doses of DTX were given during peak CD8 T cell activation, demonstrating that Treg can be depleted on multiple occasions, but only when CD8 T cell activation has returned to base line levels. Finally, we show that even minimal Treg depletion is sufficient to significantly improve the efficacy of tumor‐peptide vaccination. Conclusions BALB/c.FoxP3.dtr mice are an ideal model to investigate the full therapeutic potential of Treg depletion to boost anti‐tumor immunity. DTX‐mediated Treg depletion is transient, dose‐dependent, and leads to strong anti‐tumor immunity and complete tumor regression at high doses, while enhancing the efficacy of tumor‐specific vaccination at low doses. Together this data highlight the importance of Treg manipulation as a useful strategy for enhancing current and future cancer immunotherapies. PMID:28250921

  5. Depletion sensitivity predicts unhealthy snack purchases.

    PubMed

    Salmon, Stefanie J; Adriaanse, Marieke A; Fennis, Bob M; De Vet, Emely; De Ridder, Denise T D

    2016-01-01

    The aim of the present research is to examine the relation between depletion sensitivity - a novel construct referring to the speed or ease by which one's self-control resources are drained - and snack purchase behavior. In addition, interactions between depletion sensitivity and the goal to lose weight on snack purchase behavior were explored. Participants included in the study were instructed to report every snack they bought over the course of one week. The dependent variables were the number of healthy and unhealthy snacks purchased. The results of the present study demonstrate that depletion sensitivity predicts the amount of unhealthy (but not healthy) snacks bought. The more sensitive people are to depletion, the more unhealthy snacks they buy. Moreover, there was some tentative evidence that this relation is more pronounced for people with a weak as opposed to a strong goal to lose weight, suggesting that a strong goal to lose weight may function as a motivational buffer against self-control failures. All in all, these findings provide evidence for the external validity of depletion sensitivity and the relevance of this construct in the domain of eating behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Is Ego Depletion Real? An Analysis of Arguments.

    PubMed

    Friese, Malte; Loschelder, David D; Gieseler, Karolin; Frankenbach, Julius; Inzlicht, Michael

    2018-03-01

    An influential line of research suggests that initial bouts of self-control increase the susceptibility to self-control failure (ego depletion effect). Despite seemingly abundant evidence, some researchers have suggested that evidence for ego depletion was the sole result of publication bias and p-hacking, with the true effect being indistinguishable from zero. Here, we examine (a) whether the evidence brought forward against ego depletion will convince a proponent that ego depletion does not exist and (b) whether arguments that could be brought forward in defense of ego depletion will convince a skeptic that ego depletion does exist. We conclude that despite several hundred published studies, the available evidence is inconclusive. Both additional empirical and theoretical works are needed to make a compelling case for either side of the debate. We discuss necessary steps for future work toward this aim.

  7. Self-Regulatory Capacities Are Depleted in a Domain-Specific Manner

    PubMed Central

    Zhang, Rui; Stock, Ann-Kathrin; Rzepus, Anneka; Beste, Christian

    2017-01-01

    Performing an act of self-regulation such as making decisions has been suggested to deplete a common limited resource, which impairs all subsequent self-regulatory actions (ego depletion theory). It has however remained unclear whether self-referred decisions truly impair behavioral control even in seemingly unrelated cognitive domains, and which neurophysiological mechanisms are affected by these potential depletion effects. In the current study, we therefore used an inter-individual design to compare two kinds of depletion, namely a self-referred choice-based depletion and a categorization-based switching depletion, to a non-depleted control group. We used a backward inhibition (BI) paradigm to assess the effects of depletion on task switching and associated inhibition processes. It was combined with EEG and source localization techniques to assess both behavioral and neurophysiological depletion effects. The results challenge the ego depletion theory in its current form: Opposing the theory’s prediction of a general limited resource, which should have yielded comparable effects in both depletion groups, or maybe even a larger depletion in the self-referred choice group, there were stronger performance impairments following a task domain-specific depletion (i.e., the switching-based depletion) than following a depletion based on self-referred choices. This suggests at least partly separate and independent resources for various cognitive control processes rather than just one joint resource for all self-regulation activities. The implications are crucial to consider for people making frequent far-reaching decisions e.g., in law or economy. PMID:29033798

  8. Self-Regulatory Capacities Are Depleted in a Domain-Specific Manner.

    PubMed

    Zhang, Rui; Stock, Ann-Kathrin; Rzepus, Anneka; Beste, Christian

    2017-01-01

    Performing an act of self-regulation such as making decisions has been suggested to deplete a common limited resource, which impairs all subsequent self-regulatory actions (ego depletion theory). It has however remained unclear whether self-referred decisions truly impair behavioral control even in seemingly unrelated cognitive domains, and which neurophysiological mechanisms are affected by these potential depletion effects. In the current study, we therefore used an inter-individual design to compare two kinds of depletion, namely a self-referred choice-based depletion and a categorization-based switching depletion, to a non-depleted control group. We used a backward inhibition (BI) paradigm to assess the effects of depletion on task switching and associated inhibition processes. It was combined with EEG and source localization techniques to assess both behavioral and neurophysiological depletion effects. The results challenge the ego depletion theory in its current form: Opposing the theory's prediction of a general limited resource, which should have yielded comparable effects in both depletion groups, or maybe even a larger depletion in the self-referred choice group, there were stronger performance impairments following a task domain-specific depletion (i.e., the switching-based depletion) than following a depletion based on self-referred choices. This suggests at least partly separate and independent resources for various cognitive control processes rather than just one joint resource for all self-regulation activities. The implications are crucial to consider for people making frequent far-reaching decisions e.g., in law or economy.

  9. Ultra-low-power carrier-depletion Mach-Zehnder silicon optical modulator.

    PubMed

    Ding, Jianfeng; Chen, Hongtao; Yang, Lin; Zhang, Lei; Ji, Ruiqiang; Tian, Yonghui; Zhu, Weiwei; Lu, Yangyang; Zhou, Ping; Min, Rui; Yu, Mingbin

    2012-03-26

    We demonstrate a 26 Gbit/s Mach-Zehnder silicon optical modulator. The doping concentration and profile are optimized, and a modulation efficiency with the figure of merit (VπL) of 1.28 V·cm is achieved. We design an 80-nm-wide intrinsic silicon gap between the p-type and n-type doped regions to reduce the capacitance of the diode and prevent the diode from working in a slow diffusion mode. Therefore, the modulator can be driven with a small differential voltage of 0.5 V with no bias. Without the elimination of the dissipated power of the series resistors and the reflected power of the electrical signal, the maximum power consumption is 3.8 mW.

  10. Can SCSA and TUNEL forecast apoptosis-related motility depletion in Asthenozoospermia?

    PubMed

    Moradian Fard, Z; Naghdi, M; Salehi, P; Ajami, A; Deemeh, M R; Meshkibaf, M H

    2018-05-21

    This study is an attempt to determine the power of SCSA and TUNEL for the evaluation of apoptosis status and apoptosis-related motility depletion in Asthenozoospermia. Fifty-one semen samples from Asthenozoospermic and 20 samples from fertile men participated in this study. SCSA and TUNEL were applied for the assessment of DNA integrity by flow cytometry. Annexin V conjugated with FITC labelling and FLICA method were used for the assessment of externalisation of phosphatidylserine and spermatozoon with active Caspase 3 respectively. SCSA results were shown to have a significant correlation with EPS in live spermatozoon (r = .85, p value = .00) and spermatozoon with active Caspase 3 (r = .633, p value = .00). TUNEL result was revealed to have a nonsignificant positive correlation with them. Then, Asthenozoospermic individuals were divided into two groups, SCSA higher and SCSA lower than 27%. Results interestingly indicated that the two groups significantly differed from each other in terms of TUNEL, EPS in live spermatozoon, spermatozoon with active Caspase 3 and sperm vitality (p value = .00). Both SCSA and TUNEL were correlated with apoptosis-related motility depletion in Asthenozoospermia. However, SCSA might be more powerful than TUNEL and could provide reliable information about DNA, chromatin integrity and apoptosis status in Asthenozoospermia. © 2018 Blackwell Verlag GmbH.

  11. Long-term groundwater depletion in the United States

    USGS Publications Warehouse

    Konikow, Leonard F.

    2015-01-01

    The volume of groundwater stored in the subsurface in the United States decreased by almost 1000 km3 during 1900–2008. The aquifer systems with the three largest volumes of storage depletion include the High Plains aquifer, the Mississippi Embayment section of the Gulf Coastal Plain aquifer system, and the Central Valley of California. Depletion rates accelerated during 1945–1960, averaging 13.6 km3/year during the last half of the century, and after 2000 increased again to about 24 km3/year. Depletion intensity is a new parameter, introduced here, to provide a more consistent basis for comparing storage depletion problems among various aquifers by factoring in time and areal extent of the aquifer. During 2001–2008, the Central Valley of California had the largest depletion intensity. Groundwater depletion in the United States can explain 1.4% of observed sea-level rise during the 108-year study period and 2.1% during 2001–2008. Groundwater depletion must be confronted on local and regional scales to help reduce demand (primarily in irrigated agriculture) and/or increase supply.

  12. Polar stratospheric clouds and ozone depletion

    NASA Technical Reports Server (NTRS)

    Toon, Owen B.; Turco, Richard P.

    1991-01-01

    A review is presented of investigations into the correlation between the depletion of ozone and the formation of polar stratospheric clouds (PSCs). Satellite measurements from Nimbus 7 showed that over the years the depletion from austral spring to austral spring has generally worsened. Approximately 70 percent of the ozone above Antarctica, which equals about 3 percent of the earth's ozone, is lost during September and October. Various hypotheses for ozone depletion are discussed including the theory suggesting that chlorine compounds might be responsible for the ozone hole, whereby chlorine enters the atmosphere as a component of chlorofluorocarbons produced by humans. The three types of PSCs, nitric acid trihydrate, slowly cooling water-ice, and rapidly cooling water-ice clouds act as important components of the Antarctic ozone depletion. It is indicated that destruction of the ozone will be more severe each year for the next few decades, leading to a doubling in area of the Antarctic ozone hole.

  13. Experimentally investigate ionospheric depletion chemicals in artificially created ionosphere

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu Yu; Cao Jinxiang; Wang Jian

    2012-09-15

    A new approach for investigating ionosphere chemical depletion in the laboratory is introduced. Air glow discharge plasma closely resembling the ionosphere in both composition and chemical reactions is used as the artificially created ionosphere. The ionospheric depletion experiment is accomplished by releasing chemicals such as SF{sub 6}, CCl{sub 2}F{sub 2}, and CO{sub 2} into the model discharge. The evolution of the electron density is investigated by varying the plasma pressure and input power. It is found that the negative ion (SF{sub 6}{sup -}, CCl{sub 2}F{sub 2}{sup -}) intermediary species provide larger reduction of the electron density than the positive ionmore » (CO{sub 2}{sup +}) intermediary species. The negative ion intermediary species are also more efficient in producing ionospheric holes because of their fast reaction rates. Airglow enhancement attributed to SF{sub 6} and CO{sub 2} releases agrees well with the published data. Compared to the traditional methods, the new scheme is simpler to use, both in the release of chemicals and in the electron density measurements. It is therefore more efficient for investigating the release of chemicals in the ionosphere.« less

  14. Brief mindfulness induction could reduce aggression after depletion.

    PubMed

    Yusainy, Cleoputri; Lawrence, Claire

    2015-05-01

    Many experiments have shown that one's ability to refrain from acting on aggressive impulses is likely to decrease following a prior act of self-control. This temporary state of self-control failure is known as ego-depletion. Although mindfulness is increasingly used to treat and manage aggressive behaviour, the extent to which mindfulness may counteract the depletion effect on aggression is yet to be determined. This study (N=110) investigated the effect of a laboratory induced one-time mindfulness meditation session on aggression following depletion. Aggression was assessed by the intensity of aversive noise blast participants delivered to an opponent on a computerised task. Depleted participants who received mindfulness induction behaved less aggressively than depleted participants with no mindfulness induction. Mindfulness also improved performance on a second measure of self-control (i.e., handgrip perseverance); however, this effect was independent of depletion condition. Motivational factors may help explain the dynamics of mindfulness, self-control, and aggression. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Cortical stimulation evokes abnormal responses in the dopamine-depleted rat basal ganglia.

    PubMed

    Kita, Hitoshi; Kita, Takako

    2011-07-13

    The motor cortex (MC) sends massive projections to the basal ganglia. Motor disabilities in patients and animal models of Parkinson's disease (PD) may be caused by dopamine (DA)-depleted basal ganglia that abnormally process the information originating from MC. To study how DA depletion alters signal transfer in the basal ganglia, MC stimulation-induced (MC-induced) unitary responses were recorded from the basal ganglia of control and 6-hydroxydopamine-treated hemi-parkinsonian rats anesthetized with isoflurane. This report describes new findings about how DA depletion alters MC-induced responses. MC stimulation evokes an excitation in normally quiescent striatal (Str) neurons projecting to the globus pallidus external segment (GPe). After DA-depletion, the spontaneous firing of Str-GPe neurons increases, and MC stimulation evokes a shorter latency excitation followed by a long-lasting inhibition that was invisible under normal conditions. The increased firing activity and the newly exposed long inhibition generate tonic inhibition and a disfacilitation in GPe. The disfacilitation in GPe is then amplified in basal ganglia circuitry and generates a powerful long inhibition in the basal ganglia output nucleus, the globus pallidus internal segment. Intra-Str injections of a behaviorally effective dose of DA precursor l-3,4-dihydroxyphenylalanine effectively reversed these changes. These newly observed mechanisms also support the generation of pauses and burst activity commonly observed in the basal ganglia of parkinsonian subjects. These results suggest that the generation of abnormal response sequences in the basal ganglia contributes to the development of motor disabilities in PD and that intra-Str DA supplements effectively suppress abnormal signal transfer.

  16. Origin and timescale of volatile element depletion in crustal and mantle reservoirs

    NASA Astrophysics Data System (ADS)

    Moynier, Frederic; Day, James M. D.

    2014-05-01

    Volatile elements play a fundamental role in the evolution of planets. Understanding of how volatile budgets were set in planets, and how and to what extent planetary bodies became volatile-depleted during the earliest stages of Earth and Solar System formation remain poorly understood, however. It has been proposed that the depletion is due to incomplete condensation (volatile elements were not there in the first place, in which case the timing would have to be fast, <1Myr), or that planetary bodies lost volatile elements through evaporation (post-accretion volatilization). Volatilization is known to fractionate isotopes, thus comparing isotope ratios of volatile element between samples is a powerful tool for understanding the origin of volatile element abundance variations. For example, recent work has shown that lunar basalts are enriched in the heavier isotopes of Zn (~1 ‰ for 66Zn/64Zn) compared to chondrites, terrestrial and martian basalts. We will discuss these Zn isotopic data of crustal and mantle rocks, as well as other stable isotopic systems (e.g., Si) in relation with the giant impact theory of lunar origin, as well as the lunar magma ocean and expand to other parent bodies (e.g., angrites). The timescale of depletion in volatile elements of Solar System material is estimated by using radiogenic systems for which the parent and daughter elements have different volatility. Here we focus on the Rb-Sr and Mn-Cr isotopic systems and discuss the timescales and implications for the origin of volatile element depletion (solar nebula stage vs. planetary stage).

  17. 26 CFR 52.4682-1 - Ozone-depleting chemicals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 17 2014-04-01 2014-04-01 false Ozone-depleting chemicals. 52.4682-1 Section 52... EXCISE TAXES (CONTINUED) ENVIRONMENTAL TAXES § 52.4682-1 Ozone-depleting chemicals. (a) Overview. This section provides rules relating to the tax imposed on ozone-depleting chemicals (ODCs) under section 4681...

  18. 26 CFR 52.4682-1 - Ozone-depleting chemicals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 17 2012-04-01 2012-04-01 false Ozone-depleting chemicals. 52.4682-1 Section 52... EXCISE TAXES (CONTINUED) ENVIRONMENTAL TAXES § 52.4682-1 Ozone-depleting chemicals. (a) Overview. This section provides rules relating to the tax imposed on ozone-depleting chemicals (ODCs) under section 4681...

  19. 26 CFR 52.4682-1 - Ozone-depleting chemicals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Ozone-depleting chemicals. 52.4682-1 Section 52... EXCISE TAXES (CONTINUED) ENVIRONMENTAL TAXES § 52.4682-1 Ozone-depleting chemicals. (a) Overview. This section provides rules relating to the tax imposed on ozone-depleting chemicals (ODCs) under section 4681...

  20. 26 CFR 52.4682-1 - Ozone-depleting chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Ozone-depleting chemicals. 52.4682-1 Section 52... EXCISE TAXES (CONTINUED) ENVIRONMENTAL TAXES § 52.4682-1 Ozone-depleting chemicals. (a) Overview. This section provides rules relating to the tax imposed on ozone-depleting chemicals (ODCs) under section 4681...

  1. Possible ozone depletions following nuclear explosions

    NASA Technical Reports Server (NTRS)

    Whitten, R. C.; Borucki, W. J.; Turco, R. P.

    1975-01-01

    The degree of depletion of the ozone layer ensuing after delivery of strategic nuclear warheads (5000 and 10,000 Mton) due to production of nitrogen oxides is theoretically assessed. Strong depletions are calculated for 16-km and 26-km altitudes, peaking 1-2 months after detonation and lasting for three years, while a significant depletion at 36 km would peak after one year. Assuming the explosions occur between 30 and 70 deg N, these effects should be much more pronounced in this region than over the Northern Hemisphere as a whole. It is concluded that Hampson's concern on this matter (1974) is well-founded.-

  2. Regret causes ego-depletion and finding benefits in the regrettable events alleviates ego-depletion.

    PubMed

    Gao, Hongmei; Zhang, Yan; Wang, Fang; Xu, Yan; Hong, Ying-Yi; Jiang, Jiang

    2014-01-01

    This study tested the hypotheses that experiencing regret would result in ego-depletion, while finding benefits (i.e., "silver linings") in the regret-eliciting events counteracted the ego-depletion effect. Using a modified gambling paradigm (Experiments 1, 2, and 4) and a retrospective method (Experiments 3 and 5), five experiments were conducted to induce regret. Results revealed that experiencing regret undermined performance on subsequent tasks, including a paper-and-pencil calculation task (Experiment 1), a Stroop task (Experiment 2), and a mental arithmetic task (Experiment 3). Furthermore, finding benefits in the regret-eliciting events improved subsequent performance (Experiments 4 and 5), and this improvement was mediated by participants' perceived vitality (Experiment 4). This study extended the depletion model of self-regulation by considering emotions with self-conscious components (in our case, regret). Moreover, it provided a comprehensive understanding of how people felt and performed after experiencing regret and after finding benefits in the events that caused the regret.

  3. A definition of depletion of fish stocks

    USGS Publications Warehouse

    Van Oosten, John

    1949-01-01

    Attention was focused on the need of a common and better understanding of the term depletion as applied to the fisheries in order to eliminate if possible the existing inexactness of thought on the subject. Depletion has been confused at various times with at least ten different ideas associated with it but which, as has has heen pointed out, are not synonymous at all. In defining depletion we must recognize that the term represents a condition and must not he confounded with the cause (overfishing) that leads to this condition or with the symptoms that identify it. Depletion was defined as a reduction, through overfishing, in the level of abundance of the exploitable segment of a stock that prevents the realization of the maximum productive capacity.

  4. Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity.

    PubMed

    Okada, Kazushi; Fukui, Masayuki; Zhu, Bao-Ting

    2016-08-26

    Glutathione depletion is a distinct cause underlying many forms of pathogenesis associated with oxidative stress and cytotoxicity. Earlier studies showed that glutamate-induced glutathione depletion in immortalized murine HT22 hippocampal neuronal cells leads to accumulation of reactive oxygen species (ROS) and ultimately cell death, but the precise mechanism underlying these processes is not clear. Here we show that during the induction of glutathione depletion, nitric oxide (NO) accumulation precedes ROS accumulation. While neuronal NO synthase (nNOS) in untreated HT22 cells exists mostly as a monomer, glutathione depletion results in increased formation of the dimer nNOS, accompanied by increases in the catalytic activity. We identified that nNOS dimerization is catalyzed by protein disulfide isomerase (PDI). Inhibition of PDI's isomerase activity effectively abrogates glutathione depletion-induced conversion of monomer nNOS into dimer nNOS, accumulation of NO and ROS, and cytotoxicity. Furthermore, we found that PDI is present in untreated cells in an inactive S-nitrosylated form, which becomes activated following glutathione depletion via S-denitrosylation. These results reveal a novel role for PDI in mediating glutathione depletion-induced oxidative cytotoxicity, as well as its role as a valuable therapeutic target for protection against oxidative cytotoxicity. Copyright © 2016. Published by Elsevier Inc.

  5. Nature gives us strength: exposure to nature counteracts ego-depletion.

    PubMed

    Chow, Jason T; Lau, Shun

    2015-01-01

    Previous research rarely investigated the role of physical environment in counteracting ego-depletion. In the present research, we hypothesized that exposure to natural environment counteracts ego-depletion. Three experiments were conducted to test this hypothesis. In Experiment 1, initially depleted participants who viewed pictures of nature scenes showed greater persistence on a subsequent anagram task than those who were given a rest period. Experiment 2 expanded upon this finding by showing that natural environment enhanced logical reasoning performance after ego-depleting task. Experiment 3 adopted a two- (depletion vs. no-depletion) -by-two (nature exposure vs. urban exposure) factorial design. We found that nature exposure moderated the effect of depletion on anagram task performance. Taken together, the present studies offer a viable and novel strategy to mitigate the negative impacts of ego-depletion.

  6. Altered neuronal activity in the primary motor cortex and globus pallidus after dopamine depletion in rats.

    PubMed

    Wang, Min; Li, Min; Geng, Xiwen; Song, Zhimin; Albers, H Elliott; Yang, Maoquan; Zhang, Xiao; Xie, Jinlu; Qu, Qingyang; He, Tingting

    2015-01-15

    The involvement of dopamine (DA) neuron loss in the etiology of Parkinson's disease has been well documented. The neural mechanisms underlying the effects of DA loss and the resultant motor dysfunction remain unknown. To gain insights into how loss of DA disrupts the electrical processes in the cortico-subcortical network, the present study explores the effects of DA neuron depletion on electrical activity in the primary motor cortex (M1), on the external and the internal segment of the globus pallidus (GPe and GPi respectively), and on their temporal relationships. Comparison of local field potentials (LFPs) in these brain regions from unilateral hemispheric DA neuron depleted rats and neurologically intact rats revealed that the spectrum power of LFPs in 12-70Hz (for M1, and GPe) and in 25-40Hz (for GPi) was significantly greater in the DA depleted rats than that in the control group. These changes were associated with a shortening of latency in LFP activities between M1 and GPe, from several hundred milliseconds in the intact animals to close to zero in the DA depleted animals. LFP oscillations in M1 were significantly more synchronized with those in GPe in the DA depleted rats compared with those in the control rats. By contrast, the synchronization of oscillation in LFP activities between M1 and GPi did not differ between the DA depleted and intact rats. Not surprisingly, rats that had DA neuron depletion spent more time along the ladder compared with the control rats. These data suggest that enhanced oscillatory activity and increased synchronization of LFPs may contribute to movement impairment in the rat model of Parkinson's disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. ELEMENTAL DEPLETIONS IN THE MAGELLANIC CLOUDS AND THE EVOLUTION OF DEPLETIONS WITH METALLICITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tchernyshyov, Kirill; Meixner, Margaret; Seale, Jonathan

    2015-10-01

    We present a study of the composition of gas and dust in the Large and Small Magellanic Clouds (LMC and SMC) using UV absorption spectroscopy. We measure P ii and Fe ii along 84 spatially distributed sightlines toward the MCs using archival Far Ultraviolet Spectroscopic Explorer observations. For 16 of those sightlines, we also measure Si ii, Cr ii, and Zn ii from new Hubble Space Telescope Cosmic Origins Spectrograph observations. We analyze these spectra using a new spectral line analysis technique based on a semi-parametric Voigt profile model. We have combined these measurements with H i and H{sub 2}more » column densities and reference stellar abundances from the literature to derive gas-phase abundances, depletions, and gas-to-dust ratios (GDRs). Of our 84 P and 16 Zn measurements, 80 and 13, respectively, are depleted by more than 0.1 dex, suggesting that P and Zn abundances are not accurate metallicity indicators at and above the metallicity of the SMC. Si, Cr, and Fe are systematically less depleted in the SMC than in the Milky Way (MW) or LMC. The minimum Si depletion in the SMC is consistent with zero. We find GDR ranges of 190–565 in the LMC and 480–2100 in the SMC, which is broadly consistent with GDRs from the literature. These ranges represent actual location to location variation and are evidence of dust destruction and/or growth in the diffuse neutral phase of the interstellar medium. Where they overlap in metallicity, the gas-phase abundances of the MW, LMC, and SMC and damped Lyα systems evolve similarly with metallicity.« less

  8. Method for depleting BWRs using optimal control rod patterns

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taner, M.S.; Levine, S.H.; Hsiao, M.Y.

    1991-01-01

    Control rod (CR) programming is an essential core management activity for boiling water reactors (BWRs). After establishing a core reload design for a BWR, CR programming is performed to develop a sequence of exposure-dependent CR patterns that assure the safe and effective depletion of the core through a reactor cycle. A time-variant target power distribution approach has been assumed in this study. The authors have developed OCTOPUS to implement a new two-step method for designing semioptimal CR programs for BWRs. The optimization procedure of OCTOPUS is based on the method of approximation programming and uses the SIMULATE-E code for nucleonicsmore » calculations.« less

  9. How Ego Depletion Affects Sexual Self-Regulation: Is It More Than Resource Depletion?

    PubMed

    Nolet, Kevin; Rouleau, Joanne-Lucine; Benbouriche, Massil; Carrier Emond, Fannie; Renaud, Patrice

    2015-12-21

    Rational thinking and decision making are impacted when in a state of sexual arousal. The inability to self-regulate arousal can be linked to numerous problems, like sexual risk taking, infidelity, and sexual coercion. Studies have shown that most men are able to exert voluntary control over their sexual excitation with various levels of success. Both situational and dispositional factors can influence self-regulation achievement. The goal of this research was to investigate how ego depletion, a state of low self-control capacity, interacts with personality traits-propensities for sexual excitation and inhibition-and cognitive absorption, to cause sexual self-regulation failure. The sexual responses of 36 heterosexual males were assessed using penile plethysmography. They were asked to control their sexual arousal in two conditions, with and without ego depletion. Results suggest that ego depletion has opposite effects based on the trait sexual inhibition, as individuals moderately inhibited showed an increase in performance while highly inhibited ones showed a decrease. These results challenge the limited resource model of self-regulation and point to the importance of considering how people adapt to acute and high challenging conditions.

  10. Simplified contaminant source depletion models as analogs of multiphase simulators

    NASA Astrophysics Data System (ADS)

    Basu, Nandita B.; Fure, Adrian D.; Jawitz, James W.

    2008-04-01

    Four simplified dense non-aqueous phase liquid (DNAPL) source depletion models recently introduced in the literature are evaluated for the prediction of long-term effects of source depletion under natural gradient flow. These models are simple in form (a power function equation is an example) but are shown here to serve as mathematical analogs to complex multiphase flow and transport simulators. The spill and subsequent dissolution of DNAPLs was simulated in domains having different hydrologic characteristics (variance of the log conductivity field = 0.2, 1 and 3) using the multiphase flow and transport simulator UTCHEM. The dissolution profiles were fitted using four analytical models: the equilibrium streamtube model (ESM), the advection dispersion model (ADM), the power law model (PLM) and the Damkohler number model (DaM). All four models, though very different in their conceptualization, include two basic parameters that describe the mean DNAPL mass and the joint variability in the velocity and DNAPL distributions. The variability parameter was observed to be strongly correlated with the variance of the log conductivity field in the ESM and ADM but weakly correlated in the PLM and DaM. The DaM also includes a third parameter that describes the effect of rate-limited dissolution, but here this parameter was held constant as the numerical simulations were found to be insensitive to local-scale mass transfer. All four models were able to emulate the characteristics of the dissolution profiles generated from the complex numerical simulator, but the one-parameter PLM fits were the poorest, especially for the low heterogeneity case.

  11. Simplified contaminant source depletion models as analogs of multiphase simulators.

    PubMed

    Basu, Nandita B; Fure, Adrian D; Jawitz, James W

    2008-04-28

    Four simplified dense non-aqueous phase liquid (DNAPL) source depletion models recently introduced in the literature are evaluated for the prediction of long-term effects of source depletion under natural gradient flow. These models are simple in form (a power function equation is an example) but are shown here to serve as mathematical analogs to complex multiphase flow and transport simulators. The spill and subsequent dissolution of DNAPLs was simulated in domains having different hydrologic characteristics (variance of the log conductivity field=0.2, 1 and 3) using the multiphase flow and transport simulator UTCHEM. The dissolution profiles were fitted using four analytical models: the equilibrium streamtube model (ESM), the advection dispersion model (ADM), the power law model (PLM) and the Damkohler number model (DaM). All four models, though very different in their conceptualization, include two basic parameters that describe the mean DNAPL mass and the joint variability in the velocity and DNAPL distributions. The variability parameter was observed to be strongly correlated with the variance of the log conductivity field in the ESM and ADM but weakly correlated in the PLM and DaM. The DaM also includes a third parameter that describes the effect of rate-limited dissolution, but here this parameter was held constant as the numerical simulations were found to be insensitive to local-scale mass transfer. All four models were able to emulate the characteristics of the dissolution profiles generated from the complex numerical simulator, but the one-parameter PLM fits were the poorest, especially for the low heterogeneity case.

  12. Mesospheric ionization and O2 1Delta(g) depletion

    NASA Technical Reports Server (NTRS)

    Spear, K. A.; Solomon, S.

    1987-01-01

    Observations of O2 1Delta(g) emission during solar proton events reveal large depletions below 80 and near 90 km. The lower-altitude depletions are believed to be due to odd hydrogen production and associated depletion of ozone, but the mechanism producing the depletion near 90 km has not yet been established. In this paper, it is proposed that an exothermic charge exchange reaction between O2(+) and O2 1Delta(g) is likely to be responsible for these high-altitude depletions. In particular, it is shown that the vertical structure of the observed change in airglow emission is consistent with this mechanism.

  13. Fully depleted back illuminated CCD

    DOEpatents

    Holland, Stephen Edward

    2001-01-01

    A backside illuminated charge coupled device (CCD) is formed of a relatively thick high resistivity photon sensitive silicon substrate, with frontside electronic circuitry, and an optically transparent backside ohmic contact for applying a backside voltage which is at least sufficient to substantially fully deplete the substrate. A greater bias voltage which overdepletes the substrate may also be applied. One way of applying the bias voltage to the substrate is by physically connecting the voltage source to the ohmic contact. An alternate way of applying the bias voltage to the substrate is to physically connect the voltage source to the frontside of the substrate, at a point outside the depletion region. Thus both frontside and backside contacts can be used for backside biasing to fully deplete the substrate. Also, high resistivity gaps around the CCD channels and electrically floating channel stop regions can be provided in the CCD array around the CCD channels. The CCD array forms an imaging sensor useful in astronomy.

  14. Flux Renormalization in Constant Power Burnup Calculations

    DOE PAGES

    Isotalo, Aarno E.; Aalto Univ., Otaniemi; Davidson, Gregory G.; ...

    2016-06-15

    To more accurately represent the desired power in a constant power burnup calculation, the depletion steps of the calculation can be divided into substeps and the neutron flux renormalized on each substep to match the desired power. Here, this paper explores how such renormalization should be performed, how large a difference it makes, and whether using renormalization affects results regarding the relative performance of different neutronics–depletion coupling schemes. When used with older coupling schemes, renormalization can provide a considerable improvement in overall accuracy. With previously published higher order coupling schemes, which are more accurate to begin with, renormalization has amore » much smaller effect. Finally, while renormalization narrows the differences in the accuracies of different coupling schemes, their order of accuracy is not affected.« less

  15. Progress in a Study of Striations in the Dust Tail of Comet Hale-Bopp (C/1995 O1)

    NASA Astrophysics Data System (ADS)

    Sekanina, Z.; Ryan, O.; Boehnhardt, H.; Birkle, K.; Engels, D.; Jaeger, M.; Keller, P.; Raab, H.

    1999-01-01

    We report preliminary results of a massive investigation of the striation patterns observed in the dust tail of comet Hale-Bopp in March and April 1997. Our findings are based on 16 wide-field photographs taken with Schmidt cameras on March 2-20, with six more, from March 31-April 8, still waiting for analysis. Altogether approximately 700 individual striae were examined on the 16 images, which were scanned and computer processed to enhance the morphology. About 5300 stria points, or some 7-8 points per stria per image on the average, were measured and their astrometric positions determined and subsequently converted to a Cartesian coordinate system, aligned with the comet's projected radius vector and centered on the nucleus. The evolution of the striated tail has been studied using the Sekanina-Farrell fragmentation hypothesis (AJ 85, 1538, 1980), previously applied to other comets. This two-step model is characterized by the time of release from the nucleus of a parent object (or objects) whose motion is assumed to have been subjected to a constant repulsive acceleration betap (presumably due to solar radiation pressure) until the time of fragmentation.

  16. Estimation of stream depletion using values of capacitance

    NASA Astrophysics Data System (ADS)

    Baldenkov, Mikhail; Filimonova, Elena

    2014-05-01

    capacitance was obtained for all three cases and is a function of aquifer hydraulic characteristics, pumping time and distance between the well and stream edge. The distance in the first and the second cases is the sum of the shortest distance between stream edge and the well and the stream leakance; in case; and in the third case, it is the sum of real distance, stream leakance and vertical leakance through the impermeable layer. A regression test between unit stream depletion (i.e. the ratio of stream reduction to pumping rate stream depletion and capacitance was performed, and power dependences were obtained in the form of Y = a + bC-0.5 The drained storage cannot be absolutely recovered by natural processes that cause 'residual' stream depletion (RSD) even in condition of perfect hydraulic connection between the stream and aquifer. The impact of various hydraulic characteristics and engineering factors on RSD was examined by numerical modeling. It was realized lack of correlation between capacitance and RSD, but exponential dependences between capacitance and the annual amplitudes of stream depletion (A) were obtained in the form of: A = 0.95 exp(- 0.776C ) Although this approach cannot assess stream-aquifer interactions to the same degree of accuracy as analytical equations of detail as a numerical model, it can provide forecast estimation with the level of primary available data.

  17. Groundwater depletion in the United States (1900−2008)

    USGS Publications Warehouse

    Konikow, Leonard F.

    2013-01-01

    A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion in the United States are not well characterized. This study evaluates long-term cumulative depletion volumes in 40 separate aquifers or areas and one land use category in the United States, bringing together information from the literature and from new analyses. Depletion is directly calculated using calibrated groundwater models, analytical approaches, or volumetric budget analyses for multiple aquifer systems. Estimated groundwater depletion in the United States during 1900–2008 totals approximately 1,000 cubic kilometers (km3). Furthermore, the rate of groundwater depletion has increased markedly since about 1950, with maximum rates occurring during the most recent period (2000–2008) when the depletion rate averaged almost 25 km3 per year (compared to 9.2 km3 per year averaged over the 1900–2008 timeframe).

  18. A Multilab Preregistered Replication of the Ego-Depletion Effect.

    PubMed

    Hagger, Martin S; Chatzisarantis, Nikos L D; Alberts, Hugo; Anggono, Calvin Octavianus; Batailler, Cédric; Birt, Angela R; Brand, Ralf; Brandt, Mark J; Brewer, Gene; Bruyneel, Sabrina; Calvillo, Dustin P; Campbell, W Keith; Cannon, Peter R; Carlucci, Marianna; Carruth, Nicholas P; Cheung, Tracy; Crowell, Adrienne; De Ridder, Denise T D; Dewitte, Siegfried; Elson, Malte; Evans, Jacqueline R; Fay, Benjamin A; Fennis, Bob M; Finley, Anna; Francis, Zoë; Heise, Elke; Hoemann, Henrik; Inzlicht, Michael; Koole, Sander L; Koppel, Lina; Kroese, Floor; Lange, Florian; Lau, Kevin; Lynch, Bridget P; Martijn, Carolien; Merckelbach, Harald; Mills, Nicole V; Michirev, Alexej; Miyake, Akira; Mosser, Alexandra E; Muise, Megan; Muller, Dominique; Muzi, Milena; Nalis, Dario; Nurwanti, Ratri; Otgaar, Henry; Philipp, Michael C; Primoceri, Pierpaolo; Rentzsch, Katrin; Ringos, Lara; Schlinkert, Caroline; Schmeichel, Brandon J; Schoch, Sarah F; Schrama, Michel; Schütz, Astrid; Stamos, Angelos; Tinghög, Gustav; Ullrich, Johannes; vanDellen, Michelle; Wimbarti, Supra; Wolff, Wanja; Yusainy, Cleoputri; Zerhouni, Oulmann; Zwienenberg, Maria

    2016-07-01

    Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental paradigm, in which people completing an initial self-control task have reduced self-control capacity and poorer performance on a subsequent task, a state known as ego depletion Although a meta-analysis of ego-depletion experiments found a medium-sized effect, subsequent meta-analyses have questioned the size and existence of the effect and identified instances of possible bias. The analyses served as a catalyst for the current Registered Replication Report of the ego-depletion effect. Multiple laboratories (k = 23, total N = 2,141) conducted replications of a standardized ego-depletion protocol based on a sequential-task paradigm by Sripada et al. Meta-analysis of the studies revealed that the size of the ego-depletion effect was small with 95% confidence intervals (CIs) that encompassed zero (d = 0.04, 95% CI [-0.07, 0.15]. We discuss implications of the findings for the ego-depletion effect and the resource depletion model of self-control. © The Author(s) 2016.

  19. Prediction of Down-Gradient Impacts of DNAPL Source Depletion Using Tracer Techniques

    NASA Astrophysics Data System (ADS)

    Basu, N. B.; Fure, A. D.; Jawitz, J. W.

    2006-12-01

    Four simplified DNAPL source depletion models that have been discussed in the literature recently are evaluated for the prediction of long-term effects of source depletion under natural gradient flow. These models are simple in form (a power function equation is an example) but are shown here to serve as mathematical analogs to complex multiphase flow and transport simulators. One of the source depletion models, the equilibrium streamtube model, is shown to be relatively easily parameterized using non-reactive and reactive tracers. Non-reactive tracers are used to characterize the aquifer heterogeneity while reactive tracers are used to describe the mean DNAPL mass and its distribution. This information is then used in a Lagrangian framework to predict source remediation performance. In a Lagrangian approach the source zone is conceptualized as a collection of non-interacting streamtubes with hydrodynamic and DNAPL heterogeneity represented by the variation of the travel time and DNAPL saturation among the streamtubes. The travel time statistics are estimated from the non-reactive tracer data while the DNAPL distribution statistics are estimated from the reactive tracer data. The combined statistics are used to define an analytical solution for contaminant dissolution under natural gradient flow. The tracer prediction technique compared favorably with results from a multiphase flow and transport simulator UTCHEM in domains with different hydrodynamic heterogeneity (variance of the log conductivity field = 0.2, 1 and 3).

  20. Groundwater depletion embedded in international food trade.

    PubMed

    Dalin, Carole; Wada, Yoshihide; Kastner, Thomas; Puma, Michael J

    2017-03-29

    Recent hydrological modelling and Earth observations have located and quantified alarming rates of groundwater depletion worldwide. This depletion is primarily due to water withdrawals for irrigation, but its connection with the main driver of irrigation, global food consumption, has not yet been explored. Here we show that approximately eleven per cent of non-renewable groundwater use for irrigation is embedded in international food trade, of which two-thirds are exported by Pakistan, the USA and India alone. Our quantification of groundwater depletion embedded in the world's food trade is based on a combination of global, crop-specific estimates of non-renewable groundwater abstraction and international food trade data. A vast majority of the world's population lives in countries sourcing nearly all their staple crop imports from partners who deplete groundwater to produce these crops, highlighting risks for global food and water security. Some countries, such as the USA, Mexico, Iran and China, are particularly exposed to these risks because they both produce and import food irrigated from rapidly depleting aquifers. Our results could help to improve the sustainability of global food production and groundwater resource management by identifying priority regions and agricultural products at risk as well as the end consumers of these products.

  1. Groundwater Depletion Embedded in International Food Trade

    NASA Technical Reports Server (NTRS)

    Dalin, Carole; Wada, Yoshihide; Kastner, Thomas; Puma, Michael J.

    2017-01-01

    Recent hydrological modeling and Earth observations have located and quantified alarming rates of groundwater depletion worldwide. This depletion is primarily due to water withdrawals for irrigation, but its connection with the main driver of irrigation, global food consumption, has not yet been explored. Here we show that approximately eleven per cent of non-renewable groundwater use for irrigation is embedded in international food trade, of which two-thirds are exported by Pakistan, the USA and India alone. Our quantification of groundwater depletion embedded in the world's food trade is based on a combination of global, crop-specific estimates of non-renewable groundwater abstraction and international food trade data. A vast majority of the world's population lives in countries sourcing nearly all their staple crop imports from partners who deplete groundwater to produce these crops, highlighting risks for global food and water security. Some countries, such as the USA, Mexico, Iran and China, are particularly exposed to these risks because they both produce and import food irrigated from rapidly depleting aquifers. Our results could help to improve the sustainability of global food production and groundwater resource management by identifying priority regions and agricultural products at risk as well as the end consumers of these products.

  2. Groundwater depletion embedded in international food trade

    NASA Astrophysics Data System (ADS)

    Dalin, Carole; Wada, Yoshihide; Kastner, Thomas; Puma, Michael J.

    2017-03-01

    Recent hydrological modelling and Earth observations have located and quantified alarming rates of groundwater depletion worldwide. This depletion is primarily due to water withdrawals for irrigation, but its connection with the main driver of irrigation, global food consumption, has not yet been explored. Here we show that approximately eleven per cent of non-renewable groundwater use for irrigation is embedded in international food trade, of which two-thirds are exported by Pakistan, the USA and India alone. Our quantification of groundwater depletion embedded in the world’s food trade is based on a combination of global, crop-specific estimates of non-renewable groundwater abstraction and international food trade data. A vast majority of the world’s population lives in countries sourcing nearly all their staple crop imports from partners who deplete groundwater to produce these crops, highlighting risks for global food and water security. Some countries, such as the USA, Mexico, Iran and China, are particularly exposed to these risks because they both produce and import food irrigated from rapidly depleting aquifers. Our results could help to improve the sustainability of global food production and groundwater resource management by identifying priority regions and agricultural products at risk as well as the end consumers of these products.

  3. Development of a microcomputer based integrated design system for high altitude long endurance aircraft

    NASA Technical Reports Server (NTRS)

    Hall, David W.; Rogan, J. Edward

    1989-01-01

    A microcomputer-based integration of aircraft design disciplines has been applied theoretically to sailplane, microwave-powered aircraft, and High Altitude Long-Endurance (HALE) aircraft configurational definition efforts. Attention is presently given to the further development of such integrated-discipline approaches through the incorporation of AI techniques; these are then applied to the aforementioned case of the HALE. The windFrame language used, which is based on HyperTalk, will allow designers to write programs using a highly graphical, user interface-oriented environment.

  4. Ozone depletion and chlorine loading potentials

    NASA Technical Reports Server (NTRS)

    Pyle, John A.; Wuebbles, Donald J.; Solomon, Susan; Zvenigorodsky, Sergei; Connell, Peter; Ko, Malcolm K. W.; Fisher, Donald A.; Stordal, Frode; Weisenstein, Debra

    1991-01-01

    The recognition of the roles of chlorine and bromine compounds in ozone depletion has led to the regulation or their source gases. Some source gases are expected to be more damaging to the ozone layer than others, so that scientific guidance regarding their relative impacts is needed for regulatory purposes. Parameters used for this purpose include the steady-state and time-dependent chlorine loading potential (CLP) and the ozone depletion potential (ODP). Chlorine loading potentials depend upon the estimated value and accuracy of atmospheric lifetimes and are subject to significant (approximately 20-50 percent) uncertainties for many gases. Ozone depletion potentials depend on the same factors, as well as the evaluation of the release of reactive chlorine and bromine from each source gas and corresponding ozone destruction within the stratosphere.

  5. Ego depletion decreases trust in economic decision making

    PubMed Central

    Ainsworth, Sarah E.; Baumeister, Roy F.; Vohs, Kathleen D.; Ariely, Dan

    2014-01-01

    Three experiments tested the effects of ego depletion on economic decision making. Participants completed a task either requiring self-control or not. Then participants learned about the trust game, in which senders are given an initial allocation of $10 to split between themselves and another person, the receiver. The receiver receives triple the amount given and can send any, all, or none of the tripled money back to the sender. Participants were assigned the role of the sender and decided how to split the initial allocation. Giving less money, and therefore not trusting the receiver, is the safe, less risky response. Participants who had exerted self-control and were depleted gave the receiver less money than those in the non-depletion condition (Experiment 1). This effect was replicated and moderated in two additional experiments. Depletion again led to lower amounts given (less trust), but primarily among participants who were told they would never meet the receiver (Experiment 2) or who were given no information about how similar they were to the receiver (Experiment 3). Amounts given did not differ for depleted and non-depleted participants who either expected to meet the receiver (Experiment 2) or were led to believe that they were very similar to the receiver (Experiment 3). Decreased trust among depleted participants was strongest among neurotics. These results imply that self-control facilitates behavioral trust, especially when no other cues signal decreased social risk in trusting, such as if an actual or possible relationship with the receiver were suggested. PMID:25013237

  6. Ly6G-mediated depletion of neutrophils is dependent on macrophages.

    PubMed

    Bruhn, Kevin W; Dekitani, Ken; Nielsen, Travis B; Pantapalangkoor, Paul; Spellberg, Brad

    2016-01-01

    Antibody-mediated depletion of neutrophils is commonly used to study neutropenia. However, the mechanisms by which antibodies deplete neutrophils have not been well defined. We noticed that mice deficient in complement and macrophages had blunted neutrophil depletion in response to anti-Ly6G monoclonal antibody (MAb) treatment. In vitro, exposure of murine neutrophils to anti-Ly6G MAb in the presence of plasma did not result in significant depletion of cells, either in the presence or absence of complement. In vivo, anti-Ly6G-mediated neutrophil depletion was abrogated following macrophage depletion, but not complement depletion, indicating a requirement for macrophages to induce neutropenia by this method. These results inform the use and limitations of anti-Ly6G antibody as an experimental tool for depleting neutrophils in various immunological settings.

  7. 26 CFR 1.613-1 - Percentage depletion; general rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Percentage depletion; general rule. 1.613-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.613-1 Percentage depletion; general rule. (a) In general. In the case of a taxpayer computing the deduction for depletion under section 611...

  8. 93% pump depletion, 3.5-W continuous-wave, singly resonant optical parametric oscillator.

    PubMed

    Bosenberg, W R; Drobshoff, A; Alexander, J I; Myers, L E; Byer, R L

    1996-09-01

    We report two cw, singly resonant optical parametric oscillator (OPO) configurations based on periodically poled lithium niobate that result in significantly higher efficiency and output power than in previous studies. Using four-mirror OPO cavities and pumping with a 1.064-microm Nd:YAG laser, we observe 93% pump depletion and obtain ~86% of the converted pump photons as useful idler output. The single-beam, in-the-bucket idler output power of 3.55 W at 3.25 microm corresponds to ~80% of quantum-limited performance. We measure and compare the amplitude noise and spectral bandwidth of the two configurations. We also demonstrate >1 W of tunable cw output over the 3.3-3.9-microm spectral range.

  9. Ozone Depletion from Nearby Supernovae

    NASA Technical Reports Server (NTRS)

    Gehrels, Neil; Laird, Claude M.; Jackman, Charles H.; Cannizzo, John K.; Mattson, Barbara J.; Chen, Wan; Bhartia, P. K. (Technical Monitor)

    2002-01-01

    Estimates made in the 1970's indicated that a supernova occurring within tens of parsecs of Earth could have significant effects on the ozone layer. Since that time improved tools for detailed modeling of atmospheric chemistry have been developed to calculate ozone depletion, and advances have been made also in theoretical modeling of supernovae and of the resultant gamma ray spectra. In addition, one now has better knowledge of the occurrence rate of supernovae in the galaxy, and of the spatial distribution of progenitors to core-collapse supernovae. We report here the results of two-dimensional atmospheric model calculations that take as input the spectral energy distribution of a supernova, adopting various distances from Earth and various latitude impact angles. In separate simulations we calculate the ozone depletion due to both gamma rays and cosmic rays. We find that for the combined ozone depletion from these effects roughly to double the 'biologically active' UV flux received at the surface of the Earth, the supernova must occur at approximately or less than 8 parsecs.

  10. Issues in Stratospheric Ozone Depletion.

    NASA Astrophysics Data System (ADS)

    Lloyd, Steven Andrew

    Following the announcement of the discovery of the Antarctic ozone hole in 1985 there have arisen a multitude of questions pertaining to the nature and consequences of polar ozone depletion. This thesis addresses several of these specific questions, using both computer models of chemical kinetics and the Earth's radiation field as well as laboratory kinetic experiments. A coupled chemical kinetic-radiative numerical model was developed to assist in the analysis of in situ field measurements of several radical and neutral species in the polar and mid-latitude lower stratosphere. Modeling was used in the analysis of enhanced polar ClO, mid-latitude diurnal variation of ClO, and simultaneous measurements of OH, HO_2, H_2 O and O_3. Most importantly, such modeling was instrumental in establishing the link between the observed ClO and BrO concentrations in the Antarctic polar vortex and the observed rate of ozone depletion. The principal medical concern of stratospheric ozone depletion is that ozone loss will lead to the enhancement of ground-level UV-B radiation. Global ozone climatology (40^circS to 50^ circN latitude) was incorporated into a radiation field model to calculate the biologically accumulated dosage (BAD) of UV-B radiation, integrated over days, months, and years. The slope of the annual BAD as a function of latitude was found to correspond to epidemiological data for non-melanoma skin cancers for 30^circ -50^circN. Various ozone loss scenarios were investigated. It was found that a small ozone loss in the tropics can provide as much additional biologically effective UV-B as a much larger ozone loss at higher latitudes. Also, for ozone depletions of > 5%, the BAD of UV-B increases exponentially with decreasing ozone levels. An important key player in determining whether polar ozone depletion can propagate into the populated mid-latitudes is chlorine nitrate, ClONO_2 . As yet this molecule is only indirectly accounted for in computer models and field

  11. Children's Models of the Ozone Layer and Ozone Depletion.

    ERIC Educational Resources Information Center

    Christidou, Vasilia; Koulaidis, Vasilis

    1996-01-01

    The views of 40 primary students on ozone and its depletion were recorded through individual, semi-structured interviews. The data analysis resulted in the formation of a limited number of models concerning the distribution and role of ozone in the atmosphere, the depletion process, and the consequences of ozone depletion. Identifies five target…

  12. 26 CFR 1.642(e)-1 - Depreciation and depletion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Depreciation and depletion. 1.642(e)-1 Section 1... (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.642(e)-1 Depreciation and depletion. An estate or trust is allowed the deductions for depreciation and depletion, but only to the extent the...

  13. [Acute tryptophan depletion in eating disorders].

    PubMed

    Díaz-Marsa, M; Lozano, C; Herranz, A S; Asensio-Vegas, M J; Martín, O; Revert, L; Saiz-Ruiz, J; Carrasco, J L

    2006-01-01

    This work describes the rational bases justifying the use of acute tryptophan depletion technique in eating disorders (ED) and the methods and design used in our studies. Tryptophan depletion technique has been described and used in previous studies safely and makes it possible to evaluate the brain serotonin activity. Therefore it is used in the investigation of hypotheses on serotonergic deficiency in eating disorders. Furthermore, and given the relationship of the dysfunctions of serotonin activity with impulsive symptoms, the technique may be useful in biological differentiation of different subtypes, that is restrictive and bulimic, of ED. 57 female patients with DSM-IV eating disorders and 20 female controls were investigated with the tryptophan depletion test. A tryptophan-free amino acid solution was administered orally after a two-day low tryptophan diet to patients and controls. Free plasma tryptophan was measured at two and five hours following administration of the drink. Eating and emotional responses were measured with specific scales for five hours following the depletion. A study of the basic characteristics of the personality and impulsivity traits was also done. Relationship of the response to the test with the different clinical subtypes and with the temperamental and impulsive characteristics of the patients was studied. The test was effective in considerably reducing plasma tryptophan in five hours from baseline levels (76%) in the global sample. The test was well tolerated and no severe adverse effects were reported. Two patients withdrew from the test due to gastric intolerance. The tryptophan depletion test could be of value to study involvement of serotonin deficits in the symptomatology and pathophysiology of eating disorders.

  14. The timing and mechanism of depletion in Lewisian granulites

    NASA Technical Reports Server (NTRS)

    Cohen, A. S.; Onions, R. K.; Ohara, M. J.

    1988-01-01

    Large Ion Lithophile (LIL) depletion in Lewisian granulites is discussed. Severe depletions in U, Th, and other LIL have been well documented in Lewisan mafic and felsic gneisses, but new Pb isotopic analyses show little or no depletion in lithologies with high solidus temperatures, such as peridotite. This suggests that LIL transport in this terrane took place by removal of partial melts rather than by pervasive flooding with externally derived CO2. The Pb and Nd isotopic data gathered on these rocks show that the depletion and granulite metamorphism are distinct events about 250 Ma apart. Both fluid inclusions and cation exchange geothermometers date from the later metamorphic event and therefore have little bearing on the depletion event, suggesting a note of caution for interpretations of other granulite terranes.

  15. Human podocyte depletion in association with older age and hypertension.

    PubMed

    Puelles, Victor G; Cullen-McEwen, Luise A; Taylor, Georgina E; Li, Jinhua; Hughson, Michael D; Kerr, Peter G; Hoy, Wendy E; Bertram, John F

    2016-04-01

    Podocyte depletion plays a major role in the development and progression of glomerulosclerosis. Many kidney diseases are more common in older age and often coexist with hypertension. We hypothesized that podocyte depletion develops in association with older age and is exacerbated by hypertension. Kidneys from 19 adult Caucasian American males without overt renal disease were collected at autopsy in Mississippi. Demographic data were obtained from medical and autopsy records. Subjects were categorized by age and hypertension as potential independent and additive contributors to podocyte depletion. Design-based stereology was used to estimate individual glomerular volume and total podocyte number per glomerulus, which allowed the calculation of podocyte density (number per volume). Podocyte depletion was defined as a reduction in podocyte number (absolute depletion) or podocyte density (relative depletion). The cortical location of glomeruli (outer or inner cortex) and presence of parietal podocytes were also recorded. Older age was an independent contributor to both absolute and relative podocyte depletion, featuring glomerular hypertrophy, podocyte loss, and thus reduced podocyte density. Hypertension was an independent contributor to relative podocyte depletion by exacerbating glomerular hypertrophy, mostly in glomeruli from the inner cortex. However, hypertension was not associated with podocyte loss. Absolute and relative podocyte depletion were exacerbated by the combination of older age and hypertension. The proportion of glomeruli with parietal podocytes increased with age but not with hypertension alone. These findings demonstrate that older age and hypertension are independent and additive contributors to podocyte depletion in white American men without kidney disease. Copyright © 2016 the American Physiological Society.

  16. Crustal Structure and Evidence for a Hales Discontinuity Beneath the Seychelles Microcontinent

    NASA Astrophysics Data System (ADS)

    Hammond, J.; Kendall, J.; Collier, J.; Rumpker, G.; Pilidou, S.; Stuart, G.

    2005-12-01

    It is well known that the Seychelles Plateau consists of a sliver of continental crust cast adrift during the formation of the Indian ocean. However the extent of the continental crust beneath the microcontinent and the cause of its isolation is poorly understood. Here we use receiver functions, interstation phase velocities obtained from surface waves, and wide angle reflections from controlled-source seismic data to investigate the lithospheric structure of the region. The H-κ method is used to calculate depths and Poison's ratio at 26 temporary stations distributed across the plateau and Mascarene basin. The Vp/V_s ratios and depths at stations on the plateau are typical of continental crust. To explain the major features of the RFs a simple two layer crust is proposed for the island of Mahé. The islands of Silhouette and Nord display a more complex crust consistent with the islands volcanic history. Praslin and its satellite islands display a simpler crust but display signs of a deeper discontinuity (~40 km) beneath the Moho which is possible evidence for underplating associated with Deccan age volcanism. Bird Island (Moho~18 km) and Desroche (Moho~23 km) show signs of being situated on islands above the transition from continental to oceanic crust. Alphonse, Coetivy and Platte all show receiver functions expected for oceanic crust, with Moho depths ~10 km. Inter-station phase velocity inversions from surface waves support these results with paths sampling the plateau region showing dispersion curves expected for continental crust, and those travelling between stations off the plateau showing evidence for oceanic crust. A deeper arrival is observed on the plateau stations at ~7 s or ~65 km. This feature is also seen in wide-angle controlled source work and the inter-station phase velocity inversions. Candidate interpretion for this Hales discontinuity include a Precambrian suture assoicated with shallow subduction or a shear-zone assoicated with deformation

  17. Addressing Ozone Layer Depletion

    EPA Pesticide Factsheets

    Access information on EPA's efforts to address ozone layer depletion through regulations, collaborations with stakeholders, international treaties, partnerships with the private sector, and enforcement actions under Title VI of the Clean Air Act.

  18. Depleted Uranium: Technical Brief

    EPA Pesticide Factsheets

    This technical brief provides accepted data and references to additional sources for radiological and chemical characteristics, health risks and references for both the monitoring and measurement, and applicable treatment techniques for depleted uranium.

  19. Out of control!? How loss of self-control influences prosocial behavior: the role of power and moral values.

    PubMed

    Joosten, Anne; van Dijke, Marius; Van Hiel, Alain; De Cremer, David

    2015-01-01

    Lack of self-control has been suggested to facilitate norm-transgressing behaviors because of the operation of automatic selfish impulses. Previous research, however, has shown that people having a high moral identity may not show such selfish impulses when their self-control resources are depleted. In the present research, we extended this effect to prosocial behavior. Moreover, we investigated the role of power in the interaction between moral identity and self-control depletion. More specifically, we expected that power facilitates the externalization of internal states, which implies that for people who feel powerful, rather than powerless, depletion decreases prosocial behavior especially for those low in moral identity. A laboratory experiment and a multisource field study supported our predictions. The present finding that the interaction between self-control depletion and moral identity is contingent upon people's level of power suggests that power may enable people to refrain from helping behavior. Moreover, the findings suggest that if organizations want to improve prosocial behaviors, it may be effective to situationally induce moral values in their employees.

  20. Out of Control!? How Loss of Self-Control Influences Prosocial Behavior: The Role of Power and Moral Values

    PubMed Central

    Joosten, Anne; van Dijke, Marius; Van Hiel, Alain; De Cremer, David

    2015-01-01

    Lack of self-control has been suggested to facilitate norm-transgressing behaviors because of the operation of automatic selfish impulses. Previous research, however, has shown that people having a high moral identity may not show such selfish impulses when their self-control resources are depleted. In the present research, we extended this effect to prosocial behavior. Moreover, we investigated the role of power in the interaction between moral identity and self-control depletion. More specifically, we expected that power facilitates the externalization of internal states, which implies that for people who feel powerful, rather than powerless, depletion decreases prosocial behavior especially for those low in moral identity. A laboratory experiment and a multisource field study supported our predictions. The present finding that the interaction between self-control depletion and moral identity is contingent upon people’s level of power suggests that power may enable people to refrain from helping behavior. Moreover, the findings suggest that if organizations want to improve prosocial behaviors, it may be effective to situationally induce moral values in their employees. PMID:26024380

  1. Effects of L-histidine depletion and L-tyrosine/L-phenylalanine depletion on sensory and motor processes in healthy volunteers

    PubMed Central

    van Ruitenbeek, P; Sambeth, A; Vermeeren, A; Young, SN; Riedel, WJ

    2009-01-01

    Background and purpose: Animal studies show that histamine plays a role in cognitive functioning and that histamine H3-receptor antagonists, which increase histaminergic function through presynaptic receptors, improve cognitive performance in models of clinical cognitive deficits. In order to test such new drugs in humans, a model for cognitive impairments induced by low histaminergic functions would be useful. Studies with histamine H1-receptor antagonists have shown limitations as a model. Here we evaluated whether depletion of L-histidine, the precursor of histamine, was effective in altering measures associated with histamine in humans and the behavioural and electrophysiological (event-related-potentials) effects. Experimental approach: Seventeen healthy volunteers completed a three-way, double-blind, crossover study with L-histidine depletion, L-tyrosine/L-phenylalanine depletion (active control) and placebo as treatments. Interactions with task manipulations in a choice reaction time task were studied. Task demands were increased using visual stimulus degradation and increased response complexity. In addition, subjective and objective measures of sedation and critical tracking task performance were assessed. Key results: Measures of sedation and critical tracking task performance were not affected by treatment. L-histidine depletion was effective and enlarged the effect of response complexity as measured with the response-locked lateralized readiness potential onset latency. Conclusions and implications: L-histidine depletion affected response- but not stimulus-related processes, in contrast to the effects of H1-receptor antagonists which were previously found to affect primarily stimulus-related processes. L-histidine depletion is promising as a model for histamine-based cognitive impairment. However, these effects need to be confirmed by further studies. PMID:19413574

  2. Flipping the switch: power, social dominance, and expectancies of mental energy change.

    PubMed

    Egan, Patrick M; Hirt, Edward R

    2015-03-01

    Research suggests that high levels of interpersonal power can promote enhanced executive functioning capabilities. The present work explored whether this effect is contingent upon expectancies concerning power's downstream cognitive consequences. Study 1 showed that social dominance orientation (SDO) predicted idiosyncratic expectancies of mental energy change toward interpersonal power. Study 2 showed that SDO moderated the executive functioning changes associated with interpersonal power and that this moderation effect was contingent upon changes in perceived mental depletion. Study 3 showed that directly manipulating expectancies of mental energy change concerning interpersonal power moderated the executive functioning consequences of power and that this moderation effect was contingent upon SDO and changes in perceived mental depletion. Together, the present findings underscore the importance of expectancies and individual differences in understanding the effects of interpersonal power. © 2014 by the Society for Personality and Social Psychology, Inc.

  3. Meta-analysis of depleted uranium levels in the Balkan region.

    PubMed

    Besic, Larisa; Muhovic, Imer; Asic, Adna; Kurtovic-Kozaric, Amina

    2017-06-01

    In recent years, contradicting data has been published on the connection between the presence of depleted uranium and an increased cancer incidence among military personnel deployed in the Balkans during the 1992-1999 wars. This has led to numerous research articles investigating possible depleted uranium contamination of the afflicted regions of the Balkan Peninsula, namely Bosnia & Herzegovina, Serbia, Kosovo and Montenegro. The aim of this study was to collect data from previously published reports investigating the levels of depleted uranium in the Balkans and to present the data in the form of a meta-analysis. This would provide a clear image of the extent of depleted uranium contamination after the Balkan conflict. In addition, we tested the hypothesis that there is a correlation between the levels of depleted uranium and the assumed depleted uranium-related health effects. Our results suggest that the majority of the examined sites contain natural uranium, while the area of Kosovo appears to be most heavily afflicted by depleted uranium pollution, followed by Bosnia & Herzegovina. Furthermore, the results indicate that it is not possible to make a valid correlation between the health effects and depleted uranium-contaminated areas. We therefore suggest a structured collaborative plan of action where long-term monitoring of the residents of depleted uranium-afflicted areas would be performed. In conclusion, while the possibility of depleted uranium toxicity in post-conflict regions appears to exist, there currently exists no definitive proof of such effects, due to insufficient studies of potentially afflicted populations, in addition to the lack of a common epidemiological approach in the reviewed literature. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Muscle glycogen depletion and subsequent replenishment affect anaerobic capacity of horses.

    PubMed

    Lacombe, V A; Hinchcliff, K W; Geor, R J; Baskin, C R

    2001-10-01

    The purpose of this study was to determine the effect of muscle glycogen depletion and subsequent replenishment on anaerobic capacity of horses. In a blinded crossover study, seven fit horses performed glycogen-depleting exercise on two occasions. Horses were infused after glycogen-depleting exercise with either 6 g/kg body wt of glucose as a 13.5% solution in 0.9% NaCl (Glu) or with 0.9% NaCl (Sal) of equivalent volume. Subsequently, horses performed a high-speed exercise test (120% of maximal rate of oxygen consumption) to estimate maximum accumulated oxygen deficit. Replenishment of muscle glycogen was greater (P < 0.05) in Glu [from 24.7 +/- 7.2 (SE) to 116.5 +/- 7 mmol/kg wet wt before and after infusion, respectively] than in Sal (from 23.4 +/- 7.2 to 47.8 +/- 5.7 mmol/kg wet wt before and after infusion, respectively). Run time to fatigue during the high-speed exercise test (97.3 +/- 8.2 and 70.8 +/- 8.3 s, P < 0.05), maximal accumulated oxygen deficit (105.7 +/- 9.3 and 82.4 +/- 10.3 ml O(2) equivalent/kg, P < 0.05), and blood lactate concentration at the end of the high-speed exercise test (11.1 +/- 1.4 and 9.2 +/- 3.7 mmol/l, P < 0.05) were greater for Glu than for Sal, respectively. We concluded that decreased availability of skeletal muscle glycogen stores diminishes anaerobic power generation and capacity for high-intensity exercise in horses.

  5. Iron isotope composition of depleted MORB

    NASA Astrophysics Data System (ADS)

    Labidi, J.; Sio, C. K. I.; Shahar, A.

    2015-12-01

    In terrestrial basalts, iron isotope ratios are observed to weakly fractionate as a function of olivine and pyroxene crystallization. However, a ~0.1‰ difference between chondrites and MORB had been reported (Dauphas et al. 2009, Teng et al. 2013 and ref. therein). This observation could illustrate an isotope fractionation occurring during partial melting, as a function of the Fe valence in melt versus crystals. Here, we present high-precision Fe isotopic data measured by MC-ICP-MS on well-characterized samples from the Pacific-Antarctic Ridge (PAR, n=9) and from the Garrett Transform Fault (n=8). These samples allow exploring the Fe isotope fractionation between melt and magnetite, and the role of partial melting on Fe isotope fractionation. Our average δ56Fe value is +0.095±0.013‰ (95% confidence, n=17), indistinguishable from a previous estimate of +0.105±0.006‰ (95% confidence, n=43, see ref. 2). Our δ56Fe values correlate weakly with MgO contents, and correlate positively with K/Ti ratios. PAC1 DR10 shows the largest Ti and Fe depletion after titanomagnetite fractionation, with a δ56Fe value of +0.076±0.036‰. This is ~0.05‰ below other samples at a given MgO. This may illustrate a significant Fe isotope fractionation between the melt and titanomagnetite, in agreement with experimental determination (Shahar et al. 2008). GN09-02, the most incompatible-element depleted sample, has a δ56Fe value of 0.037±0.020‰. This is the lowest high-precision δ56Fe value recorded for a MORB worldwide. This basalt displays an incompatible-element depletion consistent with re-melting beneath the transform fault of mantle source that was depleted during a first melting event, beneath the ridge axis (Wendt et al. 1999). The Fe isotope observation could indicate that its mantle source underwent 56Fe depletion after a first melting event. It could alternatively indicate a lower Fe isotope fractionation during re-melting, if the source was depleted of its Fe3

  6. Depletion-based techniques for super-resolution imaging of NV-diamond

    NASA Astrophysics Data System (ADS)

    Jaskula, Jean-Christophe; Trifonov, Alexei; Glenn, David; Walsworth, Ronald

    2012-06-01

    We discuss the development and application of depletion-based techniques for super-resolution imaging of NV centers in diamond: stimulated emission depletion (STED), metastable ground state depletion (GSD), and dark state depletion (DSD). NV centers in diamond do not bleach under optical excitation, are not biotoxic, and have long-lived electronic spin coherence and spin-state-dependent fluorescence. Thus NV-diamond has great potential as a fluorescent biomarker and as a magnetic biosensor.

  7. Performance upgrades to the MCNP6 burnup capability for large scale depletion calculations

    DOE PAGES

    Fensin, M. L.; Galloway, J. D.; James, M. R.

    2015-04-11

    The first MCNP based inline Monte Carlo depletion capability was officially released from the Radiation Safety Information and Computational Center as MCNPX 2.6.0. With the merger of MCNPX and MCNP5, MCNP6 combined the capability of both simulation tools, as well as providing new advanced technology, in a single radiation transport code. The new MCNP6 depletion capability was first showcased at the International Congress for Advancements in Nuclear Power Plants (ICAPP) meeting in 2012. At that conference the new capabilities addressed included the combined distributive and shared memory parallel architecture for the burnup capability, improved memory management, physics enhancements, and newmore » predictability as compared to the H.B Robinson Benchmark. At Los Alamos National Laboratory, a special purpose cluster named “tebow,” was constructed such to maximize available RAM per CPU, as well as leveraging swap space with solid state hard drives, to allow larger scale depletion calculations (allowing for significantly more burnable regions than previously examined). As the MCNP6 burnup capability was scaled to larger numbers of burnable regions, a noticeable slowdown was realized.This paper details two specific computational performance strategies for improving calculation speedup: (1) retrieving cross sections during transport; and (2) tallying mechanisms specific to burnup in MCNP. To combat this slowdown new performance upgrades were developed and integrated into MCNP6 1.2.« less

  8. Challenges dealing with depleted uranium in Germany - Reuse or disposal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moeller, Kai D.

    2007-07-01

    During enrichment large amounts of depleted Uranium are produced. In Germany every year 2.800 tons of depleted uranium are generated. In Germany depleted uranium is not classified as radioactive waste but a resource for further enrichment. Therefore since 1996 depleted Uranium is sent to ROSATOM in Russia. However it still has to be dealt with the second generation of depleted Uranium. To evaluate the alternative actions in case a solution has to be found in Germany, several studies have been initiated by the Federal Ministry of the Environment. The work that has been carried out evaluated various possibilities to dealmore » with depleted uranium. The international studies on this field and the situation in Germany have been analyzed. In case no further enrichment is planned the depleted uranium has to be stored. In the enrichment process UF{sub 6} is generated. It is an international consensus that for storage it should be converted to U{sub 3}O{sub 8}. The necessary technique is well established. If the depleted Uranium would have to be characterized as radioactive waste, a final disposal would become necessary. For the planned Konrad repository - a repository for non heat generating radioactive waste - the amount of Uranium is limited by the licensing authority. The existing license would not allow the final disposal of large amounts of depleted Uranium in the Konrad repository. The potential effect on the safety case has not been roughly analyzed. As a result it may be necessary to think about alternatives. Several possibilities for the use of depleted uranium in the industry have been identified. Studies indicate that the properties of Uranium would make it useful in some industrial fields. Nevertheless many practical and legal questions are open. One further option may be the use as shielding e.g. in casks for transport or disposal. Possible techniques for using depleted Uranium as shielding are the use of the metallic Uranium as well as the inclusion in

  9. EVIDENCE FOR FRESH FROST LAYER ON THE BARE NUCLEUS OF COMET HALE-BOPP AT 32 AU DISTANCE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Szabo, Gyula M.; Kiss, Laszlo L.; Pal, Andras

    2012-12-10

    Here, we report that the activity of comet Hale-Bopp ceased between late 2007 and 2009 March, at about 28 AU distance from the Sun. At that time, the comet resided at a distance from the Sun that exceeded the freeze-out distance of regular comets by an order of magnitude. A Herschel Space Observatory PACS scan was taken in mid-2010, in the already inactive state of the nucleus. The albedo has been found to be surprisingly large (8.1% {+-} 0.9%), which exceeds the value known for any other comets. With re-reduction of archive Hubble Space Telescope images from 1995 and 1996,more » we confirm that the pre-perihelion albedo resembled that of an ordinary comet and was smaller by a factor of two than the post-activity albedo. Our further observations with the Very Large Telescope also confirmed that the albedo increased significantly by the end of the activity. We explain these observations by proposing gravitational redeposition of icy grains toward the end of the activity. This is plausible for such a massive body in a cold environment, where gas velocity is lowered to the range of the escape velocity. These observations also show that giant comets are not just the upscaled versions of the comets we know but can be affected by processes that are yet to be fully identified.« less

  10. Late-stage magmatic outgassing from a volatile-depleted Moon.

    PubMed

    Day, James M D; Moynier, Frédéric; Shearer, Charles K

    2017-09-05

    The abundance of volatile elements and compounds, such as zinc, potassium, chlorine, and water, provide key evidence for how Earth and the Moon formed and evolved. Currently, evidence exists for a Moon depleted in volatile elements, as well as reservoirs within the Moon with volatile abundances like Earth's depleted upper mantle. Volatile depletion is consistent with catastrophic formation, such as a giant impact, whereas a Moon with Earth-like volatile abundances suggests preservation of these volatiles, or addition through late accretion. We show, using the "Rusty Rock" impact melt breccia, 66095, that volatile enrichment on the lunar surface occurred through vapor condensation. Isotopically light Zn (δ 66 Zn = -13.7‰), heavy Cl (δ 37 Cl = +15‰), and high U/Pb supports the origin of condensates from a volatile-poor internal source formed during thermomagmatic evolution of the Moon, with long-term depletion in incompatible Cl and Pb, and lesser depletion of more-compatible Zn. Leaching experiments on mare basalt 14053 demonstrate that isotopically light Zn condensates also occur on some mare basalts after their crystallization, confirming a volatile-depleted lunar interior source with homogeneous δ 66 Zn ≈ +1.4‰. Our results show that much of the lunar interior must be significantly depleted in volatile elements and compounds and that volatile-rich rocks on the lunar surface formed through vapor condensation. Volatiles detected by remote sensing on the surface of the Moon likely have a partially condensate origin from its interior.

  11. Late-stage magmatic outgassing from a volatile-depleted Moon

    NASA Astrophysics Data System (ADS)

    Day, James M. D.; Moynier, Frédéric; Shearer, Charles K.

    2017-09-01

    The abundance of volatile elements and compounds, such as zinc, potassium, chlorine, and water, provide key evidence for how Earth and the Moon formed and evolved. Currently, evidence exists for a Moon depleted in volatile elements, as well as reservoirs within the Moon with volatile abundances like Earth’s depleted upper mantle. Volatile depletion is consistent with catastrophic formation, such as a giant impact, whereas a Moon with Earth-like volatile abundances suggests preservation of these volatiles, or addition through late accretion. We show, using the “Rusty Rock” impact melt breccia, 66095, that volatile enrichment on the lunar surface occurred through vapor condensation. Isotopically light Zn (δ66Zn = -13.7‰), heavy Cl (δ37Cl = +15‰), and high U/Pb supports the origin of condensates from a volatile-poor internal source formed during thermomagmatic evolution of the Moon, with long-term depletion in incompatible Cl and Pb, and lesser depletion of more-compatible Zn. Leaching experiments on mare basalt 14053 demonstrate that isotopically light Zn condensates also occur on some mare basalts after their crystallization, confirming a volatile-depleted lunar interior source with homogeneous δ66Zn ≈ +1.4‰. Our results show that much of the lunar interior must be significantly depleted in volatile elements and compounds and that volatile-rich rocks on the lunar surface formed through vapor condensation. Volatiles detected by remote sensing on the surface of the Moon likely have a partially condensate origin from its interior.

  12. Self-regulation, ego depletion, and inhibition.

    PubMed

    Baumeister, Roy F

    2014-12-01

    Inhibition is a major form of self-regulation. As such, it depends on self-awareness and comparing oneself to standards and is also susceptible to fluctuations in willpower resources. Ego depletion is the state of reduced willpower caused by prior exertion of self-control. Ego depletion undermines inhibition both because restraints are weaker and because urges are felt more intensely than usual. Conscious inhibition of desires is a pervasive feature of everyday life and may be a requirement of life in civilized, cultural society, and in that sense it goes to the evolved core of human nature. Intentional inhibition not only restrains antisocial impulses but can also facilitate optimal performance, such as during test taking. Self-regulation and ego depletion- may also affect less intentional forms of inhibition, even chronic tendencies to inhibit. Broadly stated, inhibition is necessary for human social life and nearly all societies encourage and enforce it. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Bond rupture between colloidal particles with a depletion interaction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whitaker, Kathryn A.; Furst, Eric M., E-mail: furst@udel.edu

    The force required to break the bonds of a depletion gel is measured by dynamically loading pairs of colloidal particles suspended in a solution of a nonadsorbing polymer. Sterically stabilized poly(methyl methacrylate) colloids that are 2.7 μm diameter are brought into contact in a solvent mixture of cyclohexane-cyclohexyl bromide and polystyrene polymer depletant. The particle pairs are subject to a tensile load at a constant loading rate over many approach-retraction cycles. The stochastic nature of the thermal rupture events results in a distribution of bond rupture forces with an average magnitude and variance that increases with increasing depletant concentration. The measuredmore » force distribution is described by the flux of particle pairs sampling the energy barrier of the bond interaction potential based on the Asakura–Oosawa depletion model. A transition state model demonstrates the significance of lubrication hydrodynamic interactions and the effect of the applied loading rate on the rupture force of bonds in a depletion gel.« less

  14. Abundances and Depletions of Neutron-capture Elements in the Interstellar Medium

    NASA Astrophysics Data System (ADS)

    Ritchey, A. M.; Federman, S. R.; Lambert, D. L.

    2018-06-01

    We present an extensive analysis of the gas-phase abundances and depletion behaviors of neutron-capture elements in the interstellar medium (ISM). Column densities (or upper limits to the column densities) of Ga II, Ge II, As II, Kr I, Cd II, Sn II, and Pb II are determined for a sample of 69 sight lines with high- and/or medium-resolution archival spectra obtained with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. An additional 59 sight lines with column density measurements reported in the literature are included in our analysis. Parameters that characterize the depletion trends of the elements are derived according to the methodology developed by Jenkins. (In an appendix, we present similar depletion results for the light element B.) The depletion patterns exhibited by Ga and Ge comport with expectations based on the depletion results obtained for many other elements. Arsenic exhibits much less depletion than expected, and its abundance in low-depletion sight lines may even be supersolar. We confirm a previous finding by Jenkins that the depletion of Kr increases as the overall depletion level increases from one sight line to another. Cadmium shows no such evidence of increasing depletion. We find a significant amount of scatter in the gas-phase abundances of Sn and Pb. For Sn, at least, the scatter may be evidence of real intrinsic abundance variations due to s-process enrichment combined with inefficient mixing in the ISM.

  15. 26 CFR 1.611-1 - Allowance of deduction for depletion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.611-1 Allowance of deduction for depletion. (a) Depletion of mines, oil and gas wells, other natural deposits, and timber—(1) In general... of the property. In the case of other exhaustible natural resources the allowance for depletion shall...

  16. 26 CFR 1.611-1 - Allowance of deduction for depletion.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.611-1 Allowance of deduction for depletion. (a) Depletion of mines, oil and gas wells, other natural deposits, and timber—(1) In general... of the property. In the case of other exhaustible natural resources the allowance for depletion shall...

  17. Depletion of mesospheric sodium during extended period of pulsating aurora

    NASA Astrophysics Data System (ADS)

    Takahashi, T.; Hosokawa, K.; Nozawa, S.; Tsuda, T. T.; Ogawa, Y.; Tsutsumi, M.; Hiraki, Y.; Fujiwara, H.; Kawahara, T. D.; Saito, N.; Wada, S.; Kawabata, T.; Hall, C.

    2017-01-01

    We quantitatively evaluated the Na density depletion due to charge transfer reactions between Na atoms and molecular ions produced by high-energy electron precipitation during a pulsating aurora (PsA). An extended period of PsA was captured by an all-sky camera at the European Incoherent Scatter (EISCAT) radar Tromsø site (69.6°N, 19.2°E) during a 2 h interval from 00:00 to 02:00 UT on 25 January 2012. During this period, using the EISCAT very high frequency (VHF) radar, we detected three intervals of intense ionization below 100 km that were probably caused by precipitation of high-energy electrons during the PsA. In these intervals, the sodium lidar at Tromsø observed characteristic depletion of Na density at altitudes between 97 and 100 km. These Na density depletions lasted for 8 min and represented 5-8% of the background Na layer. To examine the cause of this depletion, we modeled the depletion rate based on charge transfer reactions with NO+ and O2+ while changing the R value which is defined as the ratio of NO+ to O2+ densities, from 1 to 10. The correlation coefficients between observed and modeled Na density depletion calculated with typical value R = 3 for time intervals T1, T2, and T3 were 0.66, 0.80, and 0.67, respectively. The observed Na density depletion rates fall within the range of modeled depletion rate calculated with R from 1 to 10. This suggests that the charge transfer reactions triggered by the auroral impact ionization at low altitudes are the predominant process responsible for Na density depletion during PsA intervals.

  18. Optimal Allocation of Sampling Effort in Depletion Surveys

    EPA Science Inventory

    We consider the problem of designing a depletion or removal survey as part of estimating animal abundance for populations with imperfect capture or detection rates. In a depletion survey, animals are captured from a given area, counted, and withheld from the population. This proc...

  19. It Is Chloride Depletion Alkalosis, Not Contraction Alkalosis

    PubMed Central

    Galla, John H.

    2012-01-01

    Maintenance of metabolic alkalosis generated by chloride depletion is often attributed to volume contraction. In balance and clearance studies in rats and humans, we showed that chloride repletion in the face of persisting alkali loading, volume contraction, and potassium and sodium depletion completely corrects alkalosis by a renal mechanism. Nephron segment studies strongly suggest the corrective response is orchestrated in the collecting duct, which has several transporters integral to acid-base regulation, the most important of which is pendrin, a luminal Cl/HCO3− exchanger. Chloride depletion alkalosis should replace the notion of contraction alkalosis. PMID:22223876

  20. Alternatives to ozone depleting refrigerants in test equipment

    NASA Technical Reports Server (NTRS)

    Hall, Richard L.; Johnson, Madeleine R.

    1995-01-01

    This paper describes the initial results of a refrigerant retrofit project at the Aerospace Guidance and Metrology Center (AGMC) at Newark Air Force Base, Ohio. The objective is to convert selected types of test equipment to properly operate on hydrofluorocarbon (HFC) alternative refrigerants, having no ozone depleting potential, without compromising system reliability or durability. This paper discusses the primary technical issues and summarizes the test results for 17 different types of test equipment: ten environmental chambers, two ultralow temperature freezers, two coolant recirculators, one temperature control unit, one vapor degreaser, and one refrigerant recovery system. The postconversion performance test results have been very encouraging: system capacity and input power remained virtually unchanged. In some cases, the minimum operating temperature increased by a few degrees as a result of the conversion, but never beyond AGMC's functional requirements.

  1. Late-stage magmatic outgassing from a volatile-depleted Moon

    PubMed Central

    Moynier, Frédéric; Shearer, Charles K.

    2017-01-01

    The abundance of volatile elements and compounds, such as zinc, potassium, chlorine, and water, provide key evidence for how Earth and the Moon formed and evolved. Currently, evidence exists for a Moon depleted in volatile elements, as well as reservoirs within the Moon with volatile abundances like Earth’s depleted upper mantle. Volatile depletion is consistent with catastrophic formation, such as a giant impact, whereas a Moon with Earth-like volatile abundances suggests preservation of these volatiles, or addition through late accretion. We show, using the “Rusty Rock” impact melt breccia, 66095, that volatile enrichment on the lunar surface occurred through vapor condensation. Isotopically light Zn (δ66Zn = −13.7‰), heavy Cl (δ37Cl = +15‰), and high U/Pb supports the origin of condensates from a volatile-poor internal source formed during thermomagmatic evolution of the Moon, with long-term depletion in incompatible Cl and Pb, and lesser depletion of more-compatible Zn. Leaching experiments on mare basalt 14053 demonstrate that isotopically light Zn condensates also occur on some mare basalts after their crystallization, confirming a volatile-depleted lunar interior source with homogeneous δ66Zn ≈ +1.4‰. Our results show that much of the lunar interior must be significantly depleted in volatile elements and compounds and that volatile-rich rocks on the lunar surface formed through vapor condensation. Volatiles detected by remote sensing on the surface of the Moon likely have a partially condensate origin from its interior. PMID:28827322

  2. Revised Depletions and New Constraints on Interstellar Dust Composition

    NASA Technical Reports Server (NTRS)

    Snow, Theodore P.; Witt, Adolf N.

    1996-01-01

    We have reviewed the literature on composition of young stars, both hot and cool, as well as older solar-type stars. We find that all these classes of stars have lower abundances of the heavy elements (specifically C, N, O, Mg, Si, and Fe) than the sun. Therefore studies of interstellar depletions in which the solar composition is used as the reference standard are probably in error, tending to overestimate the total quantities of these elements, hence the depletions. We have revised the depletion estimates, using stellar abundances as the reference standard and making use of recent IS gas-phase abundance measurements. As a result of our revised depletions, we can place new and stringent constraints on several published models for the interstellar dust.

  3. Interstellar abundances and depletions inferred from observations of neutral atoms

    NASA Technical Reports Server (NTRS)

    Snow, T. P.

    1984-01-01

    Data on neutral atomic species are analyzed for the purpose of inferring relative elemental abundances and depletions in diffuse cloud cores, where it is assumed that densities are enhanced in comparison with mean densities over integrated lines of sight. Column densities of neutral atoms are compared to yield relative column densities of singly ionized species, which are assumed dominant in cloud cores. This paper incorporates a survey of literature data on neutral atomic abundances with the result that no systematic enhancement in the depletions of calcium or iron in cloud cores is found, except for zeta Ophiuchi. This may imply that depletions are not influenced by density, but other data argue against this interpretation. It is concluded either that in general all elements are depleted together in dense regions so that their relative abundances remain constant, or that typical diffuse clouds do not have significant cores, but instead are reasonably homogeneous. The data show a probable correlation between cloud-core depletion and hydrogen-molecular fraction, supporting the assumption that overall depletions are a function of density.

  4. Examining depletion theories under conditions of within-task transfer.

    PubMed

    Brewer, Gene A; Lau, Kevin K H; Wingert, Kimberly M; Ball, B Hunter; Blais, Chris

    2017-07-01

    In everyday life, mental fatigue can be detrimental across many domains including driving, learning, and working. Given the importance of understanding and accounting for the deleterious effects of mental fatigue on behavior, a growing body of literature has studied the role of motivational and executive control processes in mental fatigue. In typical laboratory paradigms, participants complete a task that places demand on these self-control processes and are later given a subsequent task. Generally speaking, decrements to subsequent task performance are taken as evidence that the initial task created mental fatigue through the continued engagement of motivational and executive functions. Several models have been developed to account for negative transfer resulting from this "ego depletion." In the current study, we provide a brief literature review, specify current theoretical approaches to ego-depletion, and report an empirical test of current models of depletion. Across 4 experiments we found minimal evidence for executive control depletion along with strong evidence for motivation mediated ego depletion. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  5. Health behaviours and their facilitation under depletion conditions: the case of snacking.

    PubMed

    Sellahewa, Dilan A; Mullan, Barbara

    2015-07-01

    Previous research suggests that depletion (the state ensuing from self-control exertion) engenders lapses in health behaviours. The present study tested for that effect in relation to the health behaviour of limiting snacking, and investigated whether health goal-priming might facilitate such health behaviours even under depletion conditions. A laboratory study was conducted involving an analytic sample of 85 undergraduates (mean age = 20.08, SD = 3.96; female: n= 63). Depletion was manipulated by having participants watch a humorous video while suppressing their responses (depletion condition) or remaining natural (non-depletion condition). The activation of participants' health goals was then manipulated by subtly exposing (goal-priming condition) or not exposing (non-priming condition) participants to health-related words in a Scrambled Sentence Task. Finally, snacking was measured using a bogus taste-test. Controlling for initial hunger, snacking was higher among depleted compared to non-depleted participants. Snacking was lower among primed compared to non-primed participants. The interaction between depletion and goal-priming was not significant. These findings suggest that depletion should be recognised as a risk factor for lapses in health behaviours, and that health goal-priming may be a useful technique for facilitating such behaviours even when individuals are depleted. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Evolution of depleted mantle: The lead perspective

    NASA Astrophysics Data System (ADS)

    Tilton, George R.

    1983-07-01

    Isotopic data have established that, compared to estimated bulk earth abundances, the sources of oceanic basaltic lavas have been depleted in large ion lithophile elements for at least several billions of years. Various data on the Tertiary-Mesozoic Gorgona komatiite and Cretaceous Oka carbonatite show that those rocks also sample depleted mantle sources. This information is used by analogy to compare Pb isotopic data from 2.6 billion year old komatiite and carbonatite from the Suomussalmi belt of eastern Finland and Munro Township, Ontario that are with associated granitic rocks and ores that should contain marked crustal components. Within experimental error no differences are detected in the isotopic composition of initial Pb in either of the rock suites. These observations agree closely with Sr and Nd data from other laboratories showing that depleted mantle could not have originated in those areas more than a few tenths of billions of years before the rocks were emplaced. On a world-wide basis the Pb isotope data are consistent with production of depleted mantle by continuous differentiation processes acting over approximately the past 3 billion years. The data show that Pb evolution is more complex than the simpler models derived from the Rb-Sr and Sm-Nd systems. The nature of the complexity is still poorly understood.

  7. Associative Interactions in Crowded Solutions of Biopolymers Counteract Depletion Effects.

    PubMed

    Groen, Joost; Foschepoth, David; te Brinke, Esra; Boersma, Arnold J; Imamura, Hiromi; Rivas, Germán; Heus, Hans A; Huck, Wilhelm T S

    2015-10-14

    The cytosol of Escherichia coli is an extremely crowded environment, containing high concentrations of biopolymers which occupy 20-30% of the available volume. Such conditions are expected to yield depletion forces, which strongly promote macromolecular complexation. However, crowded macromolecule solutions, like the cytosol, are very prone to nonspecific associative interactions that can potentially counteract depletion. It remains unclear how the cytosol balances these opposing interactions. We used a FRET-based probe to systematically study depletion in vitro in different crowded environments, including a cytosolic mimic, E. coli lysate. We also studied bundle formation of FtsZ protofilaments under identical crowded conditions as a probe for depletion interactions at much larger overlap volumes of the probe molecule. The FRET probe showed a more compact conformation in synthetic crowding agents, suggesting strong depletion interactions. However, depletion was completely negated in cell lysate and other protein crowding agents, where the FRET probe even occupied slightly more volume. In contrast, bundle formation of FtsZ protofilaments proceeded as readily in E. coli lysate and other protein solutions as in synthetic crowding agents. Our experimental results and model suggest that, in crowded biopolymer solutions, associative interactions counterbalance depletion forces for small macromolecules. Furthermore, the net effects of macromolecular crowding will be dependent on both the size of the macromolecule and its associative interactions with the crowded background.

  8. Aberrations in stimulated emission depletion (STED) microscopy

    NASA Astrophysics Data System (ADS)

    Antonello, Jacopo; Burke, Daniel; Booth, Martin J.

    2017-12-01

    Like all methods of super-resolution microscopy, stimulated emission depletion (STED) microscopy can suffer from the effects of aberrations. The most important aspect of a STED microscope is that the depletion focus maintains a minimum, ideally zero, intensity point that is surrounded by a region of higher intensity. It follows that aberrations that cause a non-zero value of this minimum intensity are the most detrimental, as they inhibit fluorescence emission even at the centre of the depletion focus. We present analysis that elucidates the nature of these effects in terms of the different polarisation components at the focus for two-dimensional and three-dimensional STED resolution enhancement. It is found that only certain low-order aberration modes can affect the minimum intensity at the Gaussian focus. This has important consequences for the design of adaptive optics aberration correction systems.

  9. The ultimate disposition of depleted uranium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1990-12-01

    Significant amounts of the depleted uranium (DU) created by past uranium enrichment activities have been sold, disposed of commercially, or utilized by defense programs. In recent years, however, the demand for DU has become quite small compared to quantities available, and within the US Department of Energy (DOE) there is concern for any risks and/or cost liabilities that might be associated with the ever-growing inventory of this material. As a result, Martin Marietta Energy Systems, Inc. (Energy Systems), was asked to review options and to develop a comprehensive plan for inventory management and the ultimate disposition of DU accumulated atmore » the gaseous diffusion plants (GDPs). An Energy Systems task team, under the chairmanship of T. R. Lemons, was formed in late 1989 to provide advice and guidance for this task. This report reviews options and recommends actions and objectives in the management of working inventories of partially depleted feed (PDF) materials and for the ultimate disposition of fully depleted uranium (FDU). Actions that should be considered are as follows. (1) Inspect UF{sub 6} cylinders on a semiannual basis. (2) Upgrade cylinder maintenance and storage yards. (3) Convert FDU to U{sub 3}O{sub 8} for long-term storage or disposal. This will include provisions for partial recovery of costs to offset those associated with DU inventory management and the ultimate disposal of FDU. Another recommendation is to drop the term tails'' in favor of depleted uranium'' or DU'' because the tails'' label implies that it is waste.'' 13 refs.« less

  10. The Influence of Chronic Ego Depletion on Goal Adherence: An Experience Sampling Study.

    PubMed

    Wang, Ligang; Tao, Ting; Fan, Chunlei; Gao, Wenbin; Wei, Chuguang

    2015-01-01

    Although ego depletion effects have been widely observed in experiments in which participants perform consecutive self-control tasks, the process of ego depletion remains poorly understood. Using the strength model of self-control, we hypothesized that chronic ego depletion adversely affects goal adherence and that mental effort and motivation are involved in the process of ego depletion. In this study, 203 students reported their daily performance, mental effort, and motivation with respect to goal directed behavior across a 3-week time period. People with high levels of chronic ego depletion were less successful in goal adherence than those with less chronic ego depletion. Although daily effort devoted to goal adherence increased with chronic ego depletion, motivation to adhere to goals was not affected. Participants with high levels of chronic ego depletion showed a stronger positive association between mental effort and performance, but chronic ego depletion did not play a regulatory role in the effect of motivation on performance. Chronic ego depletion increased the likelihood of behavior regulation failure, suggesting that it is difficult for people in an ego-depletion state to adhere to goals. We integrate our results with the findings of previous studies and discuss possible theoretical implications.

  11. Muscle glycogen depletion patterns during draught work in Standardbred horses.

    PubMed

    Gottlieb, M

    1989-03-01

    Muscle fibre recruitment was investigated during draught loaded exercise by studying glycogen depletion patterns from histochemical stains of muscle biopsies from the gluteus and semitendinosus muscles. Three Standardbred trotters performed several intervals of draught loaded exercise on a treadmill with 34 kp at a trot (7 m/sec) and with 34 and 80 kp, respectively at a walk (2m/sec). Exercise was continued until the horses were unwilling to continue. Glycogen depletion was seen in all three fibre types when trotting with 34 kp for 5 or 10 mins. When an equal weight resistance was pulled at a walk, glycogen depletion was first seen in type I fibres only, then followed by a small percentage of type IIA fibres after at least 1 h. When 80 kp was pulled at a walk both type I and IIA fibres showed glycogen depletion, and after at least 30 mins exercise a small percentage of type IIB fibres was also depleted. These results indicate that the muscle fibres are depleted, in order, from type I through IIA to IIB as the intensity or duration of draught work increases.

  12. Depletion and capture: revisiting "the source of water derived from wells".

    PubMed

    Konikow, L F; Leake, S A

    2014-09-01

    A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

  13. Weather Requirements and Procedures for Step 1: High Altitude Long Endurance (HALE) Unmanned Aircraft System (UAS) Flight Operations in the National Air Space (NAS)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    This cover sheet is for version 2 of the weather requirements document along with Appendix A. The purpose of the requirements document was to identify and to list the weather functional requirements needed to achieve the Access 5 vision of "operating High Altitude, Long Endurance (HALE) Unmanned Aircraft Systems (UAS) routinely, safely, and reliably in the National Airspace System (NAS) for Step 1." A discussion of the Federal Aviation Administration (FAA) references and related policies, procedures, and standards is provided as basis for the recommendations supported within this document. Additional procedures and reference documentation related to weather functional requirements is also provided for background. The functional requirements and related information are to be proposed to the FAA and various standards organizations for consideration and approval. The appendix was designed to show that sources of flight weather information are readily available to UAS pilots conducting missions in the NAS. All weather information for this presentation was obtained from the public internet.

  14. Terrestrial ozone depletion due to a Milky Way gamma-ray burst

    NASA Astrophysics Data System (ADS)

    Thomas, Brian C.

    Gamma-Ray Bursts (GRBs) are short, incredibly powerful astrophysical events which produce a flux of radiation detectable across the observable universe. A GRB within our own galaxy could cause major damage to the Earth's biosphere. Rate estimates suggest that at least one GRB has occurred within a dangerous range (about 2 kpc) in the last billion years. The gamma radiation from such a burst would quickly deplete much of the Earth's protective ozone layer, allowing an increase in solar UVB radiation reaching the surface. This radiation is harmful to life, causing sunburn and damaging DNA. In addition, NO 2 produced in the atmosphere would cause a decrease in visible sunlight reaching the surface and could cause global cooling. Nitric acid rain could stress portions of the biosphere, but the increased nitrate deposition could be helpful to land plants. We have used a two-dimensional atmospheric model to investigate the effects on the Earth's atmosphere of a GRB. We have simulated bursts delivering a range of fluences, at various latitudes, at the equinoxes and solstices, and at different times of day. We have computed DNA damage caused by increased solar UVB radiation, reduction in solar visible light due to NO 2 opacity; and deposition of nitrates through rainout of HNO 3 . For a "typical" burst in the last billion years, we find globally averaged ozone depletion up to 38%. Localized depletion reaches as much as 74%. Significant global depletion (at least 10%) persists up to about 7 years after the burst. Our results depend strongly on time of year and latitude over which the burst occurs. We find DNA damage of up to 16 times the normal annual global average, with greatest damage occurring at low to mid latitudes. We find reductions in visible sunlight of a few percent, primarily in the polar regions. Nitrate deposition similar to or slightly greater than that currently caused by lightning is also observed. We find support in our results for the hypothesis that the

  15. The Influence of Chronic Ego Depletion on Goal Adherence: An Experience Sampling Study

    PubMed Central

    Wang, Ligang; Tao, Ting; Fan, Chunlei; Gao, Wenbin; Wei, Chuguang

    2015-01-01

    Although ego depletion effects have been widely observed in experiments in which participants perform consecutive self-control tasks, the process of ego depletion remains poorly understood. Using the strength model of self-control, we hypothesized that chronic ego depletion adversely affects goal adherence and that mental effort and motivation are involved in the process of ego depletion. In this study, 203 students reported their daily performance, mental effort, and motivation with respect to goal directed behavior across a 3-week time period. People with high levels of chronic ego depletion were less successful in goal adherence than those with less chronic ego depletion. Although daily effort devoted to goal adherence increased with chronic ego depletion, motivation to adhere to goals was not affected. Participants with high levels of chronic ego depletion showed a stronger positive association between mental effort and performance, but chronic ego depletion did not play a regulatory role in the effect of motivation on performance. Chronic ego depletion increased the likelihood of behavior regulation failure, suggesting that it is difficult for people in an ego-depletion state to adhere to goals. We integrate our results with the findings of previous studies and discuss possible theoretical implications. PMID:26562839

  16. Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury

    PubMed Central

    Rampanelli, Elena; Stroo, Ingrid; Butter, Loes M.; Teske, Gwendoline J.; Claessen, Nike; Stokman, Geurt; Florquin, Sandrine; Leemans, Jaklien C.; Dessing, Mark C.

    2017-01-01

    An accumulating body of evidence shows that gut microbiota fulfill an important role in health and disease by modulating local and systemic immunity. The importance of the microbiome in the development of kidney disease, however, is largely unknown. To study this concept, we depleted gut microbiota with broad-spectrum antibiotics and performed renal ischemia-reperfusion (I/R) injury in mice. Depletion of the microbiota significantly attenuated renal damage, dysfunction, and remote organ injury and maintained tubular integrity after renal I/R injury. Gut flora–depleted mice expressed lower levels of F4/80 and chemokine receptors CX3CR1 and CCR2 in the F4/80+ renal resident macrophage population and bone marrow (BM) monocytes than did control mice. Additionally, compared with control BM monocytes, BM monocytes from gut flora–depleted mice had decreased migratory capacity toward CX3CL1 and CCL2 ligands. To study whether these effects were driven by depletion of the microbiota, we performed fecal transplants in antibiotic-treated mice and found that transplant of fecal material from an untreated mouse abolished the protective effect of microbiota depletion upon renal I/R injury. In conclusion, we show that depletion of gut microbiota profoundly protects against renal I/R injury by reducing maturation status of F4/80+ renal resident macrophages and BM monocytes. Therefore, dampening the inflammatory response by targeting microbiota-derived mediators might be a promising therapy against I/R injury. PMID:27927779

  17. Self-Control Strength Depletion Reduces Self-Efficacy and Impairs Exercise Performance.

    PubMed

    Graham, Jeffrey D; Bray, Steven R

    2015-10-01

    The purpose of this study was to investigate the role of task self-efficacy as a psychological factor involved in the relationship between self-control depletion and physical endurance. Participants (N = 37) completed two isometric handgrip endurance trials, separated by a Stroop task, which was either congruent (control) or incongruent (causing depletion). Task self-efficacy for the second endurance trial was measured following the Stroop task. Participants in the depletion condition reported lower task self-efficacy and showed a greater reduction in performance on the second endurance trial when compared with controls. Task self-efficacy also mediated the relationship between self-control depletion and endurance performance. The results of this study provide evidence that task self-efficacy is negatively affected following self-control depletion. We recommend that task self-efficacy be further investigated as a psychological factor accounting for the negative change in self-control performance of physical endurance and sport tasks following self-control strength depletion.

  18. Detection of depleted uranium in urine of veterans from the 1991 Gulf War.

    PubMed

    Gwiazda, R H; Squibb, K; McDiarmid, M; Smith, D

    2004-01-01

    American soldiers involved in "friendly fire" accidents during the 1991 Gulf War were injured with depleted-uranium-containing fragments or possibly exposed to depleted uranium via other routes such as inhalation, ingestion, and/or wound contamination. To evaluate the presence of depleted uranium in these soldiers eight years later, the uranium concentration and depleted uranium content of urine samples were determined by inductively coupled plasma mass spectrometry in (a) depleted uranium exposed soldiers with embedded shrapnel, (b) depleted uranium exposed soldiers with no shrapnel, and (c) a reference group of deployed soldiers not involved in the friendly fire incidents. Uranium isotopic ratios measured in many urine samples injected directly into the inductively coupled plasma mass spectrometer and analyzed at a mass resolution m/delta m of 300 appeared enriched in 235U with respect to natural abundance (0.72%) due to the presence of an interference of a polyatomic molecule of mass 234.81 amu that was resolved at a mass resolution m/delta m of 4,000. The 235U abundance measured on uranium separated from these urines by anion exchange chromatography was clearly natural or depleted. Urine uranium concentrations of soldiers with shrapnel were higher than those of the two other groups, and 16 out of 17 soldiers with shrapnel had detectable depleted uranium in their urine. In depleted uranium exposed soldiers with no shrapnel, depleted uranium was detected in urine samples of 10 out of 28 soldiers. The median uranium concentration of urines with depleted uranium from soldiers without shrapnel was significantly higher than in urines with no depleted uranium, though substantial overlap in urine uranium concentrations existed between the two groups. Accordingly, assessment of depleted uranium exposure using urine must rely on uranium isotopic analyses, since urine uranium concentration is not an unequivocal indicator of depleted uranium presence in soldiers with no

  19. With Great Power Comes Great Responsibility: Navigating through Year One of the Principalship

    ERIC Educational Resources Information Center

    Reyna, Angela M.

    2017-01-01

    Given the intense pressures, expectations, and public scrutiny, school principals now undertake even greater roles and responsibilities than their predecessors (DuFour & Mattos, 2013; Kellough & Hill, 2014; Hale & Moorman, 2003; Fullan, 2003; Deal & Peterson, 2010; Koozes & Posner, 2012). New, or neophyte, principals are…

  20. Direct Visualization of an Impurity Depletion Zone

    NASA Technical Reports Server (NTRS)

    Chernov, Alex A.; Garcia-Ruiz, Juan Ma; Thomas, Bill R.

    2000-01-01

    When a crystal incorporates more impurity per unit of its volume than the impurity concentration in solution, the solution in vicinity of the growing crystal is depleted with respect to the impurity I,2. With a stagnant solution, e. g. in microgravity or gels, an impurity depletion zone expands as the crystal grows and results in greater purity in most of the outer portion of the crystal than in the core. Crystallization in gel provides an opportunity to mimic microgravity conditions and visualize the impurity depletion zone. Colorless, transparent apoferritin (M congruent to 450 KDa) crystals were grown in the presence of red holoferritin dimer as a microheterogeneous impurity (M congruent to 900 KDa) within agarose gel by counterdiffusion with Cd(2+) precipitant. Preferential trapping of dimers, (distribution coefficient K = 4 (exp 1,2)) results in weaker red color around the crystals grown in the left tube in the figure as compared to the control middle tube without crystals. The left and the middle tubes contain colored ferritin dimers, the right tube contains colored trimers. The meniscus in the left tube separate gel (below) and liquid solution containing Cd(2+) (above). Similar solutions, though without precipitants, were present on top of the middle and right tube allowing diffusion of dimers and trimers. The area of weaker color intensity around crystals directly demonstrates overlapped impurity depletion zones.

  1. Magnetic Resonance Imaging in Nondependent Pacemaker Patients with Pacemakers and Defibrillators with a Nearly Depleted Battery.

    PubMed

    Okamura, Hideo; Padmanabhan, Deepak; Watson, Robert E; Dalzell, Connie; Acker, Nancy; Jondal, Mary; Romme, Abby L; Cha, Yong-Mei; Asirvatham, Samuel J; Felmlee, Joel P; Friedman, Paul A

    2017-05-01

    Magnetic resonance imaging (MRI) in patients with non-MRI-conditional cardiac implantable electronic devices (CIEDs) has been shown to be safe when performed under closely monitored protocols. However, the safety of MRI in patients with devices with a nearly depleted battery has not been reported. Prospective data were collected between January 2008 and May 2015 in patients with non-MRI-conditional CIEDs undergoing clinically indicated MRI under institutional protocol. Patients who were pacemaker dependent were excluded. Patients whose devices were at elective replacement indicator (ERI) at the time of MRI or close to ERI (ERI or replacement for battery depletion within 3 months of scan) were identified through database review and analyzed for clinical events. MRI scans (n = 569) were performed in 442 patients. Of these, we identified 13 scans performed with a nearly depleted battery in nine patients. All scans with implantable cardioverter defibrillators (ICDs, n = 9) were uneventful. However, two scans with pacemakers close to ERI resulted in a power-on-reset (PoR) event. One scan with a pacemaker close to ERI that was programmed to DOO mode reached ERI during MRI and automatically changed to VVI mode. Additionally, one scan with a pacemaker at ERI did not allow programming. All pacemakers with events were implanted before 2005. Patients with pacemakers and ICDs with a nearly depleted battery can safely undergo MRI when patients are not pacemaker dependent. Attention should be paid because old devices can result in PoR or ERI during MRI, which may lead to oversensing and inhibition of pacing. © 2017 Wiley Periodicals, Inc.

  2. 76 FR 42127 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Memorial Drive, Kansas City, Missouri 64198-0001: 1. The Dana Hale Nelson Family Irrevocable Trust; the Lisa K. Hale Family Irrevocable Trust; the Dana Hale Nelson Irrevocable Trust for Allison Lesta Nelson; the Dana Hale Nelson Irrevocable Trust for Hayley Elizabeth Nelson; the Dana Hale Nelson Irrevocable...

  3. Parametric second Stokes Raman laser output pulse shortening to 300 ps due to depletion of pumping of intracavity Raman conversion

    NASA Astrophysics Data System (ADS)

    Smetanin, S. N.; Jelínek, M.; Kubeček, V.; Jelínková, H.; Ivleva, L. I.

    2016-10-01

    A new effect of the pulse shortening of the parametrically generated radiation down to hundreds of picosecond via depletion of pumping of intracavity Raman conversion in the miniature passively Q-switched Nd: SrMoO4 parametric self-Raman laser with the increasing energy of the shortened pulse under pulsed pumping by a high-power laser diode bar is demonstrated. The theoretical estimation of the depletion stage duration of the convertible fundamental laser radiation via intracavity Raman conversion is in agreement with the experimentally demonstrated duration of the parametrically generated pulse. Using the mathematical modeling of the pulse shortening quality and quantity deterioration is disclosed, and the solution ways are found by the optimization of the laser parameters.

  4. Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants

    PubMed Central

    Yamagami, Kanako; Yamamoto, Takaharu; Sakai, Shota; Mioka, Tetsuo; Sano, Takamitsu; Igarashi, Yasuyuki; Tanaka, Kazuma

    2015-01-01

    In eukaryotic cells, type 4 P-type ATPases function as phospholipid flippases, which translocate phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of the lipid bilayer. Flippases function in the formation of transport vesicles, but the mechanism remains unknown. Here, we isolate an arrestin-related trafficking adaptor, ART5, as a multicopy suppressor of the growth and endocytic recycling defects of flippase mutants in budding yeast. Consistent with a previous report that Art5p downregulates the inositol transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium. Interestingly, inositol depletion suppressed the defects in all five flippase mutants. Inositol depletion also partially restored the formation of secretory vesicles in a flippase mutant. Inositol depletion caused changes in lipid composition, including a decrease in phosphatidylinositol and an increase in phosphatidylserine. A reduction in phosphatidylinositol levels caused by partially depleting the phosphatidylinositol synthase Pis1p also suppressed a flippase mutation. These results suggest that inositol depletion changes the lipid composition of the endosomal/TGN membranes, which results in vesicle formation from these membranes in the absence of flippases. PMID:25781026

  5. Arginine depletion increases susceptibility to serious infections in preterm newborns

    PubMed Central

    Badurdeen, Shiraz; Mulongo, Musa; Berkley, James A.

    2015-01-01

    Preterm newborns are highly susceptible to bacterial infections. This susceptibility is regarded as being due to immaturity of multiple pathways of the immune system. However, it is unclear whether a mechanism that unifies these different, suppressed pathways exists. Here, we argue that the immune vulnerability of the preterm neonate is critically related to arginine depletion. Arginine, a “conditionally essential” amino acid, is depleted in acute catabolic states, including sepsis. Its metabolism is highly compartmentalized and regulated, including by arginase-mediated hydrolysis. Recent data suggest that arginase II-mediated arginine depletion is essential for the innate immune suppression that occurs in newborn models of bacterial challenge, impairing pathways critical for the immune response. Evidence that arginine depletion mediates protection from immune activation during first gut colonization suggests a regulatory role in controlling gut-derived pathogens. Clinical studies show that plasma arginine is depleted during sepsis. In keeping with animal studies, small clinical trials of L-arginine supplementation have shown benefit in reducing necrotizing enterocolitis in premature neonates. We propose a novel, broader hypothesis that arginine depletion during bacterial challenge is a key factor limiting the neonate's ability to mount an adequate immune response, contributing to the increased susceptibility to infections, particularly with respect to gut-derived sepsis. PMID:25360828

  6. Solar Cell to Support Perpetual Flight of High Altitude Long Endurance UAV ITB

    NASA Astrophysics Data System (ADS)

    Luqmanul Hakim, Muhammad; Silitonga, Faber Y.; Rosid, Nurhayyan H.; Mochammad Agoes Moelyadi, Ing., Dr.

    2018-04-01

    Research on a High Altitude Long Endurance (HALE) Unmanned Aerial Vehicle (UAV) is currently being conducted at Bandung Institute of Technology to reach the flight duration needed and to get the solution of today’s challenges, minimizing pollution. Besides the good aerodynamic efficiency needed, energy resource is now becoming important. The energy resource must have a good endurance, easy to get, and of course, less pollution. Discussion in this paper is about the analysis of power needed by HALE UAV while takeoff and cruise flight conditions, and then determine the amount of solar cell and battery needed by the UAV.

  7. CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

    PubMed Central

    Lin, Philana Ling; Rutledge, Tara; Green, Angela M.; Bigbee, Matthew; Fuhrman, Carl; Klein, Edwin

    2012-01-01

    Abstract CD4 T cells are believed to be important in protection against Mycobacterium tuberculosis, but the relative contribution to control of initial or latent infection is not known. Antibody-mediated depletion of CD4 T cells in M. tuberculosis-infected cynomolgus macaques was used to study the role of CD4 T cells during acute and latent infection. Anti-CD4 antibody severely reduced levels of CD4 T cells in blood, airways, and lymph nodes. Increased pathology and bacterial burden were observed in CD4-depleted monkeys during the first 8 weeks of infection compared to controls. CD4-depleted monkeys had greater interferon (IFN)-γ expression and altered expression of CD8 T cell activation markers. During latent infection, CD4 depletion resulted in clinical reactivation in only three of six monkeys. Reactivation was associated with lower CD4 T cells in the hilar lymph nodes. During both acute and latent infection, CD4 depletion was associated with reduced percentages of CXCR3+ expressing CD8 T cells, reported to be involved in T cell recruitment, regulatory function, and effector and memory T cell maturation. CXCR3+ CD8 T cells from hilar lymph nodes had more mycobacteria-specific cytokine expression and greater coexpression of multiple cytokines compared to CXCR3− CD8 T cells. CD4 T cells are required for protection against acute infection but reactivation from latent infection is dependent on the severity of depletion in the draining lymph nodes. CD4 depletion influences CD8 T cell function. This study has important implications for human HIV–M. tuberculosis coinfection. PMID:22480184

  8. Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: no effect of glutathione depletion on the oxygen enhancement ratio

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, J.B.; Russo, A.; Biaglow, J.E.

    1983-11-01

    The hypoxic and euoxic radiation response for Chinese hamster lung and A549 human lung carcinoma cells was obtained under conditions where their nonprotein thiols, consisting primarily of glutathione (GSH), were depleted by different mechanisms. The GSH conjugating reagent diethylmaleate (DEM) was compared to DL-buthionine-S,R-sulfoximine (BSO), an inhibitor of glutathionine biosynthesis. Each reagent depleted cellular GSH to less than 5% of control values. A 2-h exposure to 0.5 mM DEM or a 4- or 24-h exposure to BSO at 10 or 1 mM, respectively, depleted cellular GSH to less than 5% of control values. Both agents sensitized cells irradiated under airmore » or hypoxic conditions. When GSH levels are lowered to < 5% by both agents, hypoxic DEM-treated cells exhibited slightly greater x-ray sensitization than hypoxic BSO-treated cells. The aerobic and anoxic sensitization of the cells results in the OER's of 2.8 and 3.0 for the DEM- and BSO-treated cells compared to 2.9 for the V79 control A549. BSO-treated cells showed an OER of 3.3 versus 3 for the control. Our results suggest that GSH depletion by either BSO or DEM sensitizes aerobic cells to radiation but does not appreciably alter the OER.« less

  9. Planar Fully-Depleted-Silicon-On-Insulator technologies: Toward the 28 nm node and beyond

    NASA Astrophysics Data System (ADS)

    Doris, B.; DeSalvo, B.; Cheng, K.; Morin, P.; Vinet, M.

    2016-03-01

    This paper presents a comprehensive overview of the research done in the last decade on planar Fully-Depleted-Silicon-On-Insulator (FDSOI) technologies in the frame of the joint development program between IBM, ST Microelectronics and CEA-LETI. In particular, we review the technological developments ranging from substrate engineering to process modules that enable functionality and improve FDSOI performance over several generations. Various multi Vt integration schemes to maximize the benefits of the thin BOX FDSOI platform are discussed. Manufacturability as well as scalability concerns are highlighted and addressed. In addition, this work provides understanding of the performance/power trade-offs for FDSOI circuits and device variability. Finally, clear directions for future application-specific products are given, demonstrating that FDSOI is an attractive CMOS option for next generation high performance and low-power applications.

  10. Depleted uranium: an overview of its properties and health effects.

    PubMed

    Shawky, S

    2002-01-01

    There has been much debate about the use of depleted uranium in the Gulf War and its health effects on United States and European war veterans. However, studies on the impact of this radioactive substance on the residents of the surrounding Gulf region are far from adequate. Depleted uranium introduces large quantities of radioactive material that is hazardous to biological organisms, continues to decay for millennia and is able to travel tens of kilometres in air. If depleted uranium were used in the Gulf War, its impact on the health of people in the area would have been considerable. This review of depleted uranium--its origin, properties, uses and effects on the human environment and health--aims to trigger further research on this subject.

  11. 26 CFR 1.613-1 - Percentage depletion; general rule.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Percentage depletion; general rule. 1.613-1 Section 1.613-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.613-1 Percentage depletion; general...

  12. Comparative evaluation of seven commercial products for human serum enrichment/depletion by shotgun proteomics.

    PubMed

    Pisanu, Salvatore; Biosa, Grazia; Carcangiu, Laura; Uzzau, Sergio; Pagnozzi, Daniela

    2018-08-01

    Seven commercial products for human serum depletion/enrichment were tested and compared by shotgun proteomics. Methods were based on four different capturing agents: antibodies (Qproteome Albumin/IgG Depletion kit, ProteoPrep Immunoaffinity Albumin and IgG Depletion Kit, Top 2 Abundant Protein Depletion Spin Columns, and Top 12 Abundant Protein Depletion Spin Columns), specific ligands (Albumin/IgG Removal), mixture of antibodies and ligands (Albumin and IgG Depletion SpinTrap), and combinatorial peptide ligand libraries (ProteoMiner beads), respectively. All procedures, to a greater or lesser extent, allowed an increase of identified proteins. ProteoMiner beads provided the highest number of proteins; Albumin and IgG Depletion SpinTrap and ProteoPrep Immunoaffinity Albumin and IgG Depletion Kit resulted the most efficient in albumin removal; Top 2 and Top 12 Abundant Protein Depletion Spin Columns decreased the overall immunoglobulin levels more than other procedures, whereas specifically gamma immunoglobulins were mostly removed by Albumin and IgG Depletion SpinTrap, ProteoPrep Immunoaffinity Albumin and IgG Depletion Kit, and Top 2 Abundant Protein Depletion Spin Columns. Albumin/IgG Removal, a resin bound to a mixture of protein A and Cibacron Blue, behaved less efficiently than the other products. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.

    PubMed

    Someya, Masanori; Sakata, Koh-ichi; Matsumoto, Yoshihisa; Tauchi, Hiroshi; Kai, Masahiro; Hareyama, Masato; Fukushima, Masakazu

    2012-01-01

    Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase (DPYD), partially inhibits homologous recombination (HR) repair and has a radiosensitizing effect as well as enhanced sensitivity to Camptothecin (CPT). DPYD is the target protein for radiosensitization by Gimeracil. We investigated the mechanisms of sensitization of radiation and CPT by DPYD inhibition using DLD-1 cells treated with siRNA for DPYD. We investigated the focus formation of various kinds of proteins involved in HR and examined the phosphorylation of RPA by irradiation using Western blot analysis. DPYD depletion by siRNA significantly restrained the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of NBS1. The numbers of colocalization of NBS1 and RPA foci in DPYD-depleted cells after radiation were significantly smaller than in the control cells. These results suggest that DPYD depletion is attributable to decreased single-stranded DNA generated by the Mre11/Rad50/NBS1 complex-dependent resection of DNA double-strand break ends. The phosphorylation of RPA by irradiation was partially suppressed in DPYD-depleted cells, suggesting that DPYD depletion may partially inhibit DNA repair with HR by suppressing phosphorylation of RPA. DPYD depletion showed a radiosensitizing effect as well as enhanced sensitivity to CPT. The radiosensitizing effect of DPYD depletion plus CPT was the additive effect of DPYD depletion and CPT. DPYD depletion did not have a cell-killing effect, suggesting that DPYD depletion may not be so toxic. Considering these results, the combination of CPT and drugs that inhibit DPYD may prove useful for radiotherapy as a method of radiosensitization.

  14. Depletion and capture: revisiting “The source of water derived from wells"

    USGS Publications Warehouse

    Konikow, Leonard F.; Leake, Stanley A.

    2014-01-01

    A natural consequence of groundwater withdrawals is the removal of water from subsurface storage, but the overall rates and magnitude of groundwater depletion and capture relative to groundwater withdrawals (extraction or pumpage) have not previously been well characterized. This study assesses the partitioning of long-term cumulative withdrawal volumes into fractions derived from storage depletion and capture, where capture includes both increases in recharge and decreases in discharge. Numerical simulation of a hypothetical groundwater basin is used to further illustrate some of Theis' (1940) principles, particularly when capture is constrained by insufficient available water. Most prior studies of depletion and capture have assumed that capture is unconstrained through boundary conditions that yield linear responses. Examination of real systems indicates that capture and depletion fractions are highly variable in time and space. For a large sample of long-developed groundwater systems, the depletion fraction averages about 0.15 and the capture fraction averages about 0.85 based on cumulative volumes. Higher depletion fractions tend to occur in more arid regions, but the variation is high and the correlation coefficient between average annual precipitation and depletion fraction for individual systems is only 0.40. Because 85% of long-term pumpage is derived from capture in these real systems, capture must be recognized as a critical factor in assessing water budgets, groundwater storage depletion, and sustainability of groundwater development. Most capture translates into streamflow depletion, so it can detrimentally impact ecosystems.

  15. Programmable nanometer-scale electrolytic metal deposition and depletion

    DOEpatents

    Lee, James Weifu [Oak Ridge, TN; Greenbaum, Elias [Oak Ridge, TN

    2002-09-10

    A method of nanometer-scale deposition of a metal onto a nanostructure includes the steps of: providing a substrate having thereon at least two electrically conductive nanostructures spaced no more than about 50 .mu.m apart; and depositing metal on at least one of the nanostructures by electric field-directed, programmable, pulsed electrolytic metal deposition. Moreover, a method of nanometer-scale depletion of a metal from a nanostructure includes the steps of providing a substrate having thereon at least two electrically conductive nanostructures spaced no more than about 50 .mu.m apart, at least one of the nanostructures having a metal disposed thereon; and depleting at least a portion of the metal from the nanostructure by electric field-directed, programmable, pulsed electrolytic metal depletion. A bypass circuit enables ultra-finely controlled deposition.

  16. Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared with CD3-targeted T-cell depletion.

    PubMed

    Triplett, Brandon M; Muller, Brad; Kang, Guolian; Li, Ying; Cross, Shane J; Moen, Joseph; Cunningham, Lea; Janssen, William; Mamcarz, Ewelina; Shook, David R; Srinivasan, Ashok; Choi, John; Hayden, Randall T; Leung, Wing

    2018-02-01

    T-cell depletion (TCD) effectively reduces severe graft-versus-host disease in recipients of HLA-mismatched allografts. However, TCD is associated with delayed immune recovery and increased infections. We hypothesized that specific depletion of CD45RA+ naive T cells, rather than broad depletion of CD3+ T cells, can preserve memory-immunity in the allografts and confer protection against important viral infections in the early post-transplant period. Sixty-seven patients who received TCD haploidentical donor transplantation for hematologic malignancy on 3 consecutive trials were analyzed. Patients receiving CD45RA-depleted donor grafts had 2000-fold more donor T cells infused, significantly higher T-cell counts at Day +30 post transplant (550/μL vs 10/μL; P < .001), and higher T-cell diversity by Vbeta spectratyping at Day +100 (P < .001). Importantly, these recipients experienced a significant reduction in both the incidence (P = .002) and duration (P = .02) of any viremia (cytomegalovirus, Epstein-Barr virus, or adenovirus) in the first 6 months post transplant. Specifically, recipients of CD3-depleted grafts were more likely to experience adenovirus viremia (27% vs 4%, P = .02). CD45RA-depletion provided a large number of donor memory T cells to the recipients and was associated with enhanced early T-cell recovery and protection against viremia. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. DOPAMINE DEPLETION SLOWS RETINAL TRANSMISSION

    EPA Science Inventory

    In male hooded rats, depletion of norepinephrine and dopamine by a-methyl-paratyrosine (AMT) significantly increased the latencies of early peaks in flash-evoked potentials recorded from the visual cortex, lateral geniculate nucleus, and optic tract. These effects were not produc...

  18. Coarse-grained molecular dynamics simulations of depletion-induced interactions for soft matter systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shendruk, Tyler N., E-mail: tyler.shendruk@physics.ox.ac.uk; Bertrand, Martin; Harden, James L.

    2014-12-28

    Given the ubiquity of depletion effects in biological and other soft matter systems, it is desirable to have coarse-grained Molecular Dynamics (MD) simulation approaches appropriate for the study of complex systems. This paper examines the use of two common truncated Lennard-Jones (Weeks-Chandler-Andersen (WCA)) potentials to describe a pair of colloidal particles in a thermal bath of depletants. The shifted-WCA model is the steeper of the two repulsive potentials considered, while the combinatorial-WCA model is the softer. It is found that the depletion-induced well depth for the combinatorial-WCA model is significantly deeper than the shifted-WCA model because the resulting overlap ofmore » the colloids yields extra accessible volume for depletants. For both shifted- and combinatorial-WCA simulations, the second virial coefficients and pair potentials between colloids are demonstrated to be well approximated by the Morphometric Thermodynamics (MT) model. This agreement suggests that the presence of depletants can be accurately modelled in MD simulations by implicitly including them through simple, analytical MT forms for depletion-induced interactions. Although both WCA potentials are found to be effective generic coarse-grained simulation approaches for studying depletion effects in complicated soft matter systems, combinatorial-WCA is the more efficient approach as depletion effects are enhanced at lower depletant densities. The findings indicate that for soft matter systems that are better modelled by potentials with some compressibility, predictions from hard-sphere systems could greatly underestimate the magnitude of depletion effects at a given depletant density.« less

  19. Action versus state orientation and self-control performance after depletion.

    PubMed

    Gröpel, Peter; Baumeister, Roy F; Beckmann, Jürgen

    2014-04-01

    Three studies investigated the role of action versus state orientation in how people deal with depletion of self-control resources. Action-oriented persons were expected to continue allocating resources and hence to perform better than state-oriented persons who were expected to conserve strength. Consistent with this, action-oriented persons performed better on the d2 test of attention than state-oriented persons after a strenuous physical exercise (Study 1), showed higher acuity on the critical fusion frequency test after a test of vigilance (Study 2), and performed better on the Stroop test after a depleting sensorimotor task (Study 3). No differences emerged between action- and state-oriented persons in their initial performance and in a non-depleting context. The impact of depletion on subsequent performance is thus not fixed, but moderated by personality.

  20. Individual differences in dopamine level modulate the ego depletion effect.

    PubMed

    Dang, Junhua; Xiao, Shanshan; Liu, Ying; Jiang, Yumeng; Mao, Lihua

    2016-01-01

    Initial exertion of self-control impairs subsequent self-regulatory performance, which is referred to as the ego depletion effect. The current study examined how individual differences in dopamine level, as indexed by eye blink rate (EBR), would moderate ego depletion. An inverted-U-shaped relationship between EBR and subsequent self-regulatory performance was found when participants initially engaged in self-control but such relationship was absent in the control condition where there was no initial exertion, suggesting individuals with a medium dopamine level may be protected from the typical ego depletion effect. These findings are consistent with a cognitive explanation which considers ego depletion as a phenomenon similar to "switch costs" that would be neutralized by factors promoting flexible switching. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Hyperspectral stimulated emission depletion microscopy and methods of use thereof

    DOEpatents

    Timlin, Jerilyn A; Aaron, Jesse S

    2014-04-01

    A hyperspectral stimulated emission depletion ("STED") microscope system for high-resolution imaging of samples labeled with multiple fluorophores (e.g., two to ten fluorophores). The hyperspectral STED microscope includes a light source, optical systems configured for generating an excitation light beam and a depletion light beam, optical systems configured for focusing the excitation and depletion light beams on a sample, and systems for collecting and processing data generated by interaction of the excitation and depletion light beams with the sample. Hyperspectral STED data may be analyzed using multivariate curve resolution analysis techniques to deconvolute emission from the multiple fluorophores. The hyperspectral STED microscope described herein can be used for multi-color, subdiffraction imaging of samples (e.g., materials and biological materials) and for analyzing a tissue by Forster Resonance Energy Transfer ("FRET").

  2. Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gao Weihua; Mizukawa, Yumiko; Nakatsu, Noriyuki

    Chemical-induced glutathione depletion is thought to be caused by two types of toxicological mechanisms: PHO-type glutathione depletion [glutathione conjugated with chemicals such as phorone (PHO) or diethyl maleate (DEM)], and BSO-type glutathione depletion [i.e., glutathione synthesis inhibited by chemicals such as L-buthionine-sulfoximine (BSO)]. In order to identify mechanism-based biomarker gene sets for glutathione depletion in rat liver, male SD rats were treated with various chemicals including PHO (40, 120 and 400 mg/kg), DEM (80, 240 and 800 mg/kg), BSO (150, 450 and 1500 mg/kg), and bromobenzene (BBZ, 10, 100 and 300 mg/kg). Liver samples were taken 3, 6, 9 andmore » 24 h after administration and examined for hepatic glutathione content, physiological and pathological changes, and gene expression changes using Affymetrix GeneChip Arrays. To identify differentially expressed probe sets in response to glutathione depletion, we focused on the following two courses of events for the two types of mechanisms of glutathione depletion: a) gene expression changes occurring simultaneously in response to glutathione depletion, and b) gene expression changes after glutathione was depleted. The gene expression profiles of the identified probe sets for the two types of glutathione depletion differed markedly at times during and after glutathione depletion, whereas Srxn1 was markedly increased for both types as glutathione was depleted, suggesting that Srxn1 is a key molecule in oxidative stress related to glutathione. The extracted probe sets were refined and verified using various compounds including 13 additional positive or negative compounds, and they established two useful marker sets. One contained three probe sets (Akr7a3, Trib3 and Gstp1) that could detect conjugation-type glutathione depletors any time within 24 h after dosing, and the other contained 14 probe sets that could detect glutathione depletors by any mechanism. These two sets, with appropriate

  3. Depletion, moral identity, and unethical behavior: Why people behave unethically after self-control exertion.

    PubMed

    Wang, Yan; Wang, Guosen; Chen, Qiuju; Li, Lin

    2017-11-01

    Self-control enables people to resist short-term temptations in the service of long-term goals. Previous exertion of self-control leads to a state of ego depletion. Three studies demonstrated that ego depletion leads to a high level of unethical behavior. These studies also hypothesized and confirmed that depleted individuals behave unethically because of low moral identity. Study 1 found that depleted participants were more likely to over-report their performance than non-depleted participants. Study 2 revealed that depletion reduced people's moral identity, which in turn increased their propensity to engage in unethical behavior. Study 3 proved that priming moral identity eliminated the effect of depletion on cheating. Findings suggest that reduced moral identity accounts for the effect of self-control depletion on unethical behavior. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Characterization of vector stimulated Brillouin scattering gain over wide power range

    NASA Astrophysics Data System (ADS)

    Li, Yongqian; An, Qi; Li, Xiaojuan; Zhang, Lixin

    2017-07-01

    The wide range power dependence of vector stimulated Brillouin scattering (SBS) gain is theoretically and experimentally characterized by a mathematical model and measurement system based on the heterodyne pump-Stokes technique. The results show that SBS phase shift is much more tolerant of pump depletion than SBS amplitude gain, hence the performance improvement of the SBS-based distributed sensing system can be achieved by measuring the SBS phase shift spectrum. The discussion about the measured Brillouin spectrum width versus pump power at different Stokes powers reveals that the occurrence of nonnegligible pump depletion imposes a restriction on the determination of pump and Stokes powers in an SBS amplitude gain-based application system. The amplitude gain and phase shift of vector SBS gain increase with the increase of pump power and decrease with the increase of Stokes power, which indicates that the design strategy with smaller Stokes power and higher pump power is reasonable. And the measured center-asymmetry of the SBS phase shift spectrum is mainly caused by the nonlinear refractive index, which puts a limitation on the maximum pump power. The obtained results can provide a useful basis for the optimal design of practical vector SBS gain-based application systems.

  5. High resolution broad-band spectroscopy in the NIR using the Triplespec externally dispersed interferometer at the Hale telescope

    NASA Astrophysics Data System (ADS)

    Erskine, David J.; Edelstein, J.; Sirk, M.; Wishnow, E.; Ishikawa, Y.; McDonald, E.; Shourt, W. V.

    2014-07-01

    High resolution broad-band spectroscopy at near-infrared wavelengths has been performed using externally dis- persed interferometry (EDI) at the Hale telescope at Mt. Palomar. The EDI technique uses a field-widened Michelson interferometer in series with a dispersive spectrograph, and is able to recover a spectrum with a resolution 4 to 10 times higher than the existing grating spectrograph. This method increases the resolution well beyond the classical limits enforced by the slit width and the detector pixel Nyquist limit and, in principle, decreases the effect of pupil variation on the instrument line-shape function. The EDI technique permits arbi- trarily higher resolution measurements using the higher throughput, lower weight, size, and expense of a lower resolution spectrograph. Observations of many stars were performed with the TEDI interferometer mounted within the central hole of the 200 inch primary mirror. Light from the interferometer was then dispersed by the TripleSpec near-infrared echelle spectrograph. Continuous spectra between 950 and 2450 nm with a resolution as high as ~27,000 were recovered from data taken with TripleSpec at a native resolution of ˜2,700. Aspects of data analysis for interferometric spectral reconstruction are described. This technique has applications in im- proving measurements of high-resolution stellar template spectra, critical for precision Doppler velocimetry using conventional spectroscopic methods. A new interferometer to be applied for this purpose at visible wavelengths is under construction.

  6. High-resolution broadband spectroscopy using externally dispersed interferometry at the Hale telescope: Part 1, data analysis and results

    NASA Astrophysics Data System (ADS)

    Erskine, David J.; Edelstein, Jerry; Wishnow, Edward H.; Sirk, Martin; Muirhead, Philip S.; Muterspaugh, Matthew W.; Lloyd, James P.; Ishikawa, Yuzo; McDonald, Eliza A.; Shourt, William V.; Vanderburg, Andrew M.

    2016-04-01

    High-resolution broadband spectroscopy at near-infrared wavelengths (950 to 2450 nm) has been performed using externally dispersed interferometry (EDI) at the Hale telescope at Mt. Palomar. Observations of stars were performed with the "TEDI" interferometer mounted within the central hole of the 200-in. primary mirror in series with the comounted TripleSpec near-infrared echelle spectrograph. These are the first multidelay EDI demonstrations on starlight, as earlier measurements used a single delay or laboratory sources. We demonstrate very high (10×) resolution boost, from original 2700 to 27,000 with current set of delays (up to 3 cm), well beyond the classical limits enforced by the slit width and detector pixel Nyquist limit. Significantly, the EDI used with multiple delays rather than a single delay as used previously yields an order of magnitude or more improvement in the stability against native spectrograph point spread function (PSF) drifts along the dispersion direction. We observe a dramatic (20×) reduction in sensitivity to PSF shift using our standard processing. A recently realized method of further reducing the PSF shift sensitivity to zero is described theoretically and demonstrated in a simple simulation which produces a 350× times reduction. We demonstrate superb rejection of fixed pattern noise due to bad detector pixels-EDI only responds to changes in pixel intensity synchronous to applied dithering. This part 1 describes data analysis, results, and instrument noise. A section on theoretical photon limited sensitivity is in a companion paper, part 2.

  7. Benchmark Evaluation of Dounreay Prototype Fast Reactor Minor Actinide Depletion Measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hess, J. D.; Gauld, I. C.; Gulliford, J.

    2017-01-01

    Historic measurements of actinide samples in the Dounreay Prototype Fast Reactor (PFR) are of interest for modern nuclear data and simulation validation. Samples of various higher-actinide isotopes were irradiated for 492 effective full-power days and radiochemically assayed at Oak Ridge National Laboratory (ORNL) and Japan Atomic Energy Research Institute (JAERI). Limited data were available regarding the PFR irradiation; a six-group neutron spectra was available with some power history data to support a burnup depletion analysis validation study. Under the guidance of the Organisation for Economic Co-Operation and Development Nuclear Energy Agency (OECD NEA), the International Reactor Physics Experiment Evaluation Projectmore » (IRPhEP) and Spent Fuel Isotopic Composition (SFCOMPO) Project are collaborating to recover all measurement data pertaining to these measurements, including collaboration with the United Kingdom to obtain pertinent reactor physics design and operational history data. These activities will produce internationally peer-reviewed benchmark data to support validation of minor actinide cross section data and modern neutronic simulation of fast reactors with accompanying fuel cycle activities such as transportation, recycling, storage, and criticality safety.« less

  8. Excess depletion of Al, Ca, Ti from interstellar gas

    NASA Technical Reports Server (NTRS)

    Clayton, D. D.

    1986-01-01

    Thermal condensation, cold sticking, and sputtering by interstellar shock are combined with a chemical memory of the condensation sequence to account for depletion of aluminum, calcium, and titanium in interstellar gas. The extra depletion of aluminum and calcium becomes an indicator of the structural history of the refractory parts of interstellar grains.

  9. Indium gallium arsenide microwave power transistors

    NASA Technical Reports Server (NTRS)

    Johnson, Gregory A.; Kapoor, Vik J.; Shokrani, Mohsen; Messick, Louis J.; Nguyen, Richard

    1991-01-01

    Depletion-mode InGaAs microwave power MISFETs with 1-micron gate lengths and up to 1-mm gate widths have been fabricated using an ion-implantation process. The devices employed a plasma-deposited silicon/silicon dioxide gate insulator. The dc I-V characteristics and RF power performance at 9.7 GHz are presented. The output power, power-added efficiency, and power gain as a function of input power are reported. An output power of 1.07 W with a corresponding power gain and power-added efficiency of 4.3 dB and 38 percent, respectively, was obtained. The large-gate-width devices provided over twice the previously reported output power for InGaAs MISFETs at X-band. In addition, output power stability within 1.2 percent over 24 h of continuous operation was achieved. In addition, a drain current drift of 4 percent over 10,000 sec was obtained.

  10. Nevada Test and Training Range Depleted Uranium Target Disposal Environmental Assessment

    DTIC Science & Technology

    2005-03-01

    to establish the probability and scope of such transport. Long-Term Fate of Depleted Uranium at Aberdeen and Yuma Proving Grounds Phase II: Human...1990. Long-Term Fate of Depleted Uranium at Aberdeen and Yuma Proving Grounds Final Report, Phase 1: Geochemical Transport and Modeling. Los...of Depleted Uranium at Aberdeen and Yuma Proving Grounds , Phase II: Human Health and Ecological Risk Assessments. Los Alamos National Laboratory

  11. Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine.

    PubMed

    Filip, Szymon; Vougas, Konstantinos; Zoidakis, Jerome; Latosinska, Agnieszka; Mullen, William; Spasovski, Goce; Mischak, Harald; Vlahou, Antonia; Jankowski, Joachim

    2015-01-01

    Proteome analysis of complex biological samples for biomarker identification remains challenging, among others due to the extended range of protein concentrations. High-abundance proteins like albumin or IgG of plasma and urine, may interfere with the detection of potential disease biomarkers. Currently, several options are available for the depletion of abundant proteins in plasma. However, the applicability of these methods in urine has not been thoroughly investigated. In this study, we compared different, commercially available immunodepletion and ion-exchange based approaches on urine samples from both healthy subjects and CKD patients, for their reproducibility and efficiency in protein depletion. A starting urine volume of 500 μL was used to simulate conditions of a multi-institutional biomarker discovery study. All depletion approaches showed satisfactory reproducibility (n=5) in protein identification as well as protein abundance. Comparison of the depletion efficiency between the unfractionated and fractionated samples and the different depletion strategies, showed efficient depletion in all cases, with the exception of the ion-exchange kit. The depletion efficiency was found slightly higher in normal than in CKD samples and normal samples yielded more protein identifications than CKD samples when using both initial as well as corresponding depleted fractions. Along these lines, decrease in the amount of albumin and other targets as applicable, following depletion, was observed. Nevertheless, these depletion strategies did not yield a higher number of identifications in neither the urine from normal nor CKD patients. Collectively, when analyzing urine in the context of CKD biomarker identification, no added value of depletion strategies can be observed and analysis of unfractionated starting urine appears to be preferable.

  12. Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine

    PubMed Central

    Filip, Szymon; Vougas, Konstantinos; Zoidakis, Jerome; Latosinska, Agnieszka; Mullen, William; Spasovski, Goce; Mischak, Harald; Vlahou, Antonia; Jankowski, Joachim

    2015-01-01

    Proteome analysis of complex biological samples for biomarker identification remains challenging, among others due to the extended range of protein concentrations. High-abundance proteins like albumin or IgG of plasma and urine, may interfere with the detection of potential disease biomarkers. Currently, several options are available for the depletion of abundant proteins in plasma. However, the applicability of these methods in urine has not been thoroughly investigated. In this study, we compared different, commercially available immunodepletion and ion-exchange based approaches on urine samples from both healthy subjects and CKD patients, for their reproducibility and efficiency in protein depletion. A starting urine volume of 500 μL was used to simulate conditions of a multi-institutional biomarker discovery study. All depletion approaches showed satisfactory reproducibility (n=5) in protein identification as well as protein abundance. Comparison of the depletion efficiency between the unfractionated and fractionated samples and the different depletion strategies, showed efficient depletion in all cases, with the exception of the ion-exchange kit. The depletion efficiency was found slightly higher in normal than in CKD samples and normal samples yielded more protein identifications than CKD samples when using both initial as well as corresponding depleted fractions. Along these lines, decrease in the amount of albumin and other targets as applicable, following depletion, was observed. Nevertheless, these depletion strategies did not yield a higher number of identifications in neither the urine from normal nor CKD patients. Collectively, when analyzing urine in the context of CKD biomarker identification, no added value of depletion strategies can be observed and analysis of unfractionated starting urine appears to be preferable. PMID:26208298

  13. Depletion optimization of lumped burnable poisons in pressurized water reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kodah, Z.H.

    1982-01-01

    Techniques were developed to construct a set of basic poison depletion curves which deplete in a monotonical manner. These curves were combined to match a required optimized depletion profile by utilizing either linear or non-linear programming methods. Three computer codes, LEOPARD, XSDRN, and EXTERMINATOR-2 were used in the analyses. A depletion routine was developed and incorporated into the XSDRN code to allow the depletion of fuel, fission products, and burnable poisons. The Three Mile Island Unit-1 reactor core was used in this work as a typical PWR core. Two fundamental burnable poison rod designs were studied. They are a solidmore » cylindrical poison rod and an annular cylindrical poison rod with water filling the central region.These two designs have either a uniform mixture of burnable poisons or lumped spheroids of burnable poisons in the poison region. Boron and gadolinium are the two burnable poisons which were investigated in this project. Thermal self-shielding factor calculations for solid and annular poison rods were conducted. Also expressions for overall thermal self-shielding factors for one or more than one size group of poison spheroids inside solid and annular poison rods were derived and studied. Poison spheroids deplete at a slower rate than the poison mixture because each spheroid exhibits some self-shielding effects of its own. The larger the spheroid, the higher the self-shielding effects due to the increase in poison concentration.« less

  14. Local condensate depletion at trap center under strong interactions

    NASA Astrophysics Data System (ADS)

    Yukalov, V. I.; Yukalova, E. P.

    2018-04-01

    Cold trapped Bose-condensed atoms, interacting via hard-sphere repulsive potentials are considered. Simple mean-field approximations show that the condensate distribution inside a harmonic trap always has the shape of a hump with the maximum condensate density occurring at the trap center. However, Monte Carlo simulations at high density and strong interactions display the condensate depletion at the trap center. The explanation of this effect of local condensate depletion at trap center is suggested in the frame of self-consistent theory of Bose-condensed systems. The depletion is shown to be due to the existence of the anomalous average that takes into account pair correlations and appears in systems with broken gauge symmetry.

  15. Thermodynamic analysis of the advanced zero emission power plant

    NASA Astrophysics Data System (ADS)

    Kotowicz, Janusz; Job, Marcin

    2016-03-01

    The paper presents the structure and parameters of advanced zero emission power plant (AZEP). This concept is based on the replacement of the combustion chamber in a gas turbine by the membrane reactor. The reactor has three basic functions: (i) oxygen separation from the air through the membrane, (ii) combustion of the fuel, and (iii) heat transfer to heat the oxygen-depleted air. In the discussed unit hot depleted air is expanded in a turbine and further feeds a bottoming steam cycle (BSC) through the main heat recovery steam generator (HRSG). Flue gas leaving the membrane reactor feeds the second HRSG. The flue gas consist mainly of CO2 and water vapor, thus, CO2 separation involves only the flue gas drying. Results of the thermodynamic analysis of described power plant are presented.

  16. Endoplasmic-Reticulum Calcium Depletion and Disease

    PubMed Central

    Mekahli, Djalila; Bultynck, Geert; Parys, Jan B.; De Smedt, Humbert; Missiaen, Ludwig

    2011-01-01

    The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic Ca2+ signals, but, among other functions, also assembles and folds newly synthesized proteins. Alterations in ER homeostasis, including severe Ca2+ depletion, are an upstream event in the pathophysiology of many diseases. On the one hand, insufficient release of activator Ca2+ may no longer sustain essential cell functions. On the other hand, loss of luminal Ca2+ causes ER stress and activates an unfolded protein response, which, depending on the duration and severity of the stress, can reestablish normal ER function or lead to cell death. We will review these various diseases by mainly focusing on the mechanisms that cause ER Ca2+ depletion. PMID:21441595

  17. Depleting high-abundant and enriching low-abundant proteins in human serum: An evaluation of sample preparation methods using magnetic nanoparticle, chemical depletion and immunoaffinity techniques.

    PubMed

    de Jesus, Jemmyson Romário; da Silva Fernandes, Rafael; de Souza Pessôa, Gustavo; Raimundo, Ivo Milton; Arruda, Marco Aurélio Zezzi

    2017-08-01

    The efficiency of three different depletion methods to remove the most abundant proteins, enriching those human serum proteins with low abundance is checked to make more efficient the search and discovery of biomarkers. These methods utilize magnetic nanoparticles (MNPs), chemical reagents (sequential application of dithiothreitol and acetonitrile, DTT/ACN), and commercial apparatus based on immunoaffinity (ProteoMiner, PM). The comparison between methods shows significant removal of abundant protein, remaining in the supernatant at concentrations of 4.6±0.2, 3.6±0.1, and 3.3±0.2µgµL -1 (n=3) for MNPs, DTT/ACN and PM respectively, from a total protein content of 54µgµL -1 . Using GeLC-MS/MS analysis, MNPs depletion shows good efficiency in removing high molecular weight proteins (>80kDa). Due to the synergic effect between the reagents DTT and ACN, DTT/ACN-based depletion offers good performance in the depletion of thiol-rich proteins, such as albumin and transferrin (DTT action), as well as of high molecular weight proteins (ACN action). Furthermore, PM equalization confirms its efficiency in concentrating low-abundant proteins, decreasing the dynamic range of protein levels in human serum. Direct comparison between the treatments reveals 72 proteins identified when using MNP depletion (43 of them exclusively by this method), but only 20 proteins using DTT/ACN (seven exclusively by this method). Additionally, after PM treatment 30 proteins were identified, seven exclusively by this method. Thus, MNPs and DTT/ACN depletion can be simple, quick, cheap, and robust alternatives for immunochemistry-based protein depletion, providing a potential strategy in the search for disease biomarkers. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. 26 CFR 1.612-3 - Depletion; treatment of bonus and advanced royalty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Depletion; treatment of bonus and advanced... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.612-3 Depletion; treatment... the payee as a cost depletion deduction in respect of the bonus an amount equal to that proportion of...

  19. Evaluation of three high abundance protein depletion kits for umbilical cord serum proteomics

    PubMed Central

    2011-01-01

    Background High abundance protein depletion is a major challenge in the study of serum/plasma proteomics. Prior to this study, most commercially available kits for depletion of highly abundant proteins had only been tested and evaluated in adult serum/plasma, while the depletion efficiency on umbilical cord serum/plasma had not been clarified. Structural differences between some adult and fetal proteins (such as albumin) make it likely that depletion approaches for adult and umbilical cord serum/plasma will be variable. Therefore, the primary purposes of the present study are to investigate the efficiencies of several commonly-used commercial kits during high abundance protein depletion from umbilical cord serum and to determine which kit yields the most effective and reproducible results for further proteomics research on umbilical cord serum. Results The immunoaffinity based kits (PROTIA-Sigma and 5185-Agilent) displayed higher depletion efficiency than the immobilized dye based kit (PROTBA-Sigma) in umbilical cord serum samples. Both the PROTIA-Sigma and 5185-Agilent kit maintained high depletion efficiency when used three consecutive times. Depletion by the PROTIA-Sigma Kit improved 2DE gel quality by reducing smeared bands produced by the presence of high abundance proteins and increasing the intensity of other protein spots. During image analysis using the identical detection parameters, 411 ± 18 spots were detected in crude serum gels, while 757 ± 43 spots were detected in depleted serum gels. Eight spots unique to depleted serum gels were identified by MALDI- TOF/TOF MS, seven of which were low abundance proteins. Conclusions The immunoaffinity based kits exceeded the immobilized dye based kit in high abundance protein depletion of umbilical cord serum samples and dramatically improved 2DE gel quality for detection of trace biomarkers. PMID:21554704

  20. Depletion of the Complex Multiple Aquifer System of Jordan

    NASA Astrophysics Data System (ADS)

    Rödiger, T.; Siebert, C.; Geyer, S.; Merz, R.

    2017-12-01

    In many countries worldwide water scarcity pose a significant risk to the environment and the socio-economy. Particularly in countries where the available water resources are strongly limited by climatic conditions an accurate determination of the available water resources is of high priority, especially when water supply predominantly rely oon groundwater resources and their recharge. If groundwater abstraction exceeds the natural groundwater recharge in heavily used well field areas, overexploitation or persistent groundwater depletion occurs. This is the case in the Kingdom of Jordan, where a multi-layer aquifer complex forms the eastern subsurface catchment of the Dead Sea basin. Since the begin of the industrial and agricultural development of the country, dramatically falling groundwater levels, the disappearance of springs and saltwater intrusions from deeper aquifers is documented nation-wide. The total water budget is influenced by (i) a high climatic gradient from hyperarid to semiarid and (ii) the intnese anthropogenic abstraction. For this multi-layered aquifer system we developed a methodology to evaluate groundwater depletion by linking a hydrological and a numerical flow model including estimates of groundwater abstraction. Hence, we define groundwater depletion as the rate of groundwater abstraction in excess of natural recharge rate. Restricting our analysis, we calculated a range of groundwater depletion from 0% in the eastern Hamad basin to around 40% in the central part of Jordan and to extreme values of 100% of depletion in the Azraq and Disi basin.

  1. Coherent quantum depletion of an interacting atom condensate

    PubMed Central

    Kira, M.

    2015-01-01

    Sufficiently strong interactions promote coherent quantum transitions in spite of thermalization and losses, which are the adversaries of delicate effects such as reversibility and correlations. In atomic Bose–Einstein condensates (BECs), strong atom–atom interactions can eject atoms from the BEC to the normal component, yielding quantum depletion instead of temperature depletion. A recent experiment has already been verified to overcome losses. Here I show that it also achieves coherent quantum-depletion dynamics in a BEC swept fast enough from weak to strong atom–atom interactions. The elementary coherent process first excites the normal component into a liquid state that evolves into a spherical shell state, where the atom occupation peaks at a finite momentum to shield 50% of the BEC atoms from annihilation. The identified coherent processes resemble ultrafast semiconductor excitations expanding the scope of BEC explorations to many-body non-equilibrium studies. PMID:25767044

  2. Differential Membrane Dipolar Orientation Induced by Acute and Chronic Cholesterol Depletion.

    PubMed

    Sarkar, Parijat; Chakraborty, Hirak; Chattopadhyay, Amitabha

    2017-06-30

    Cholesterol plays a crucial role in cell membrane organization, dynamics and function. Depletion of cholesterol represents a popular approach to explore cholesterol-sensitivity of membrane proteins. An emerging body of literature shows that the consequence of membrane cholesterol depletion often depends on the actual process (acute or chronic), although the molecular mechanism underlying the difference is not clear. Acute depletion, using cyclodextrin-type carriers, is faster relative to chronic depletion, in which inhibitors of cholesterol biosynthesis are used. With the overall goal of addressing molecular differences underlying these processes, we monitored membrane dipole potential under conditions of acute and chronic cholesterol depletion in CHO-K1 cells, using a voltage-sensitive fluorescent dye in dual wavelength ratiometric mode. Our results show that the observed membrane dipole potential exhibits difference under acute and chronic cholesterol depletion conditions, even when cholesterol content was identical. To the best of our knowledge, these results provide, for the first time, molecular insight highlighting differences in dipolar reorganization in these processes. A comprehensive understanding of processes in which membrane cholesterol gets modulated would provide novel insight in its interaction with membrane proteins and receptors, thereby allowing us to understand the role of cholesterol in cellular physiology associated with health and disease.

  3. Overview of the Martian nightside suprathermal electron depletions

    NASA Astrophysics Data System (ADS)

    Steckiewicz, Morgane; Garnier, Philippe; André, Nicolas; Mitchell, David; Andersson, Laila; Penou, Emmanuel; Beth, Arnaud; Fedorov, Andrei; Sauvaud, Jean-André; Mazelle, Christian; Lillis, Robert; Brain, David; Espley, Jared; McFadden, James; Halekas, Jasper; Luhmann, Janet; Soobiah, Yasir; Jakosky, Bruce

    2017-04-01

    Nightside suprathermal electron depletions have been observed at Mars by three spacecraft to date: Mars Global Surveyor (MGS), Mars EXpress (MEX) and the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission. The global coverage of Mars by MEX and MGS at high altitudes (above approximately 250 km) revealed that these structures were mostly observed above strong crustal magnetic field sources which exclude the electrons coming from the dayside or from the tail. The MAVEN orbit now offers the possibility to observe this phenomenon at low altitudes, down to 125 km. A transition region near 170 km has been detected separating the collisional region where electron depletions are mainly due to electron absorption by atmospheric CO2 and the collisionless region where they are mainly due to closed crustal magnetic field loops. MAVEN is now in its third year of data recording and has covered a large range of latitudes, local times and solar zenith angles at low altitudes (<900km) in the nightside. These observations enable us to estimate where the EUV terminator is located, based on the observation that no electron depletions are expected above its location. Through this study the location of the EUV terminator appears to be raised on average by 125 km above the location of the geometrical terminator. However, this location is likely to be different between the dawn and dusk terminator and to vary throughout the different Martian seasons. This coverage has also allowed the observation of regions with recurrent absence of electron depletions even below the transition region near 170 km altitude. These 'no-depletion' areas are localized above the least magnetized area of Mars both in the Northern and Southern hemispheres. A modification in the CO2 density, gravity waves, or the presence of current sheets are potential drivers for that phenomenon.

  4. ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis.

    PubMed Central

    Stefanelli, C; Bonavita, F; Stanic', I; Farruggia, G; Falcieri, E; Robuffo, I; Pignatti, C; Muscari, C; Rossoni, C; Guarnieri, C; Caldarera, C M

    1997-01-01

    In quiescent thymocytes, mitochondrial de-energization was not correlated to apoptotic death. In fact, thymocytes treated with oligomycin, a highly specific inhibitor of ATP synthase, alone or with atractyloside to block ATP translocation from the cytoplasm, were alive, even if their mitochondria were depolarized, as revealed by flow cytometry after Rhodamine 123 staining. Furthermore, oligomycin was a powerful inhibitor of apoptosis induced in rat thymocytes by dexamethasone and, to a lesser extent, by the calcium ionophore A23187 and etoposide, but was without effect when apoptosis was induced by staurosporine, and increased cell death in mitogen-treated thymocytes. The inhibition of apoptosis was confirmed by morphological criteria, inhibition of inter-nucleosomal DNA fragmentation and inhibition of the loss of membrane integrity. The anti-apoptotic effect of oligomycin in cells treated with A23187 or etoposide was correlated to the inhibition of protein synthesis, while inhibition of apoptosis induced by dexamethasone, already evident at an oligomycin concentration of 10 ng/ml, was instead strictly correlated to the effect exerted on the cellular ATP level. Thymocyte apoptosis triggered by dexamethasone was blocked or delayed by inhibitors of respiratory-chain uncouplers, inhibitors of ATP synthase and antioxidants: a lasting protection from dexamethasone-induced apoptosis was always correlated to a drastic and rapid reduction in ATP level (31-35% of control), while a delay in the death process was characterized by a moderate decrease in ATP (73-82% of control). Oligomycin inhibited the specific binding of radioactive corticosteroid to thymocyte nuclei, confirming the inhibitory effect of ATP depletion on glucocorticoid binding and suggesting that ATP depletion is a common mediator of the anti-apoptotic action of different effectors in glucocorticoid-induced apoptosis. In conclusion, the reported data indicate that ATP may act as a cellular modulator of some

  5. Development of the MCNPX depletion capability: A Monte Carlo linked depletion method that automates the coupling between MCNPX and CINDER90 for high fidelity burnup calculations

    NASA Astrophysics Data System (ADS)

    Fensin, Michael Lorne

    Monte Carlo-linked depletion methods have gained recent interest due to the ability to more accurately model complex 3-dimesional geometries and better track the evolution of temporal nuclide inventory by simulating the actual physical process utilizing continuous energy coefficients. The integration of CINDER90 into the MCNPX Monte Carlo radiation transport code provides a high-fidelity completely self-contained Monte-Carlo-linked depletion capability in a well established, widely accepted Monte Carlo radiation transport code that is compatible with most nuclear criticality (KCODE) particle tracking features in MCNPX. MCNPX depletion tracks all necessary reaction rates and follows as many isotopes as cross section data permits in order to achieve a highly accurate temporal nuclide inventory solution. This work chronicles relevant nuclear history, surveys current methodologies of depletion theory, details the methodology in applied MCNPX and provides benchmark results for three independent OECD/NEA benchmarks. Relevant nuclear history, from the Oklo reactor two billion years ago to the current major United States nuclear fuel cycle development programs, is addressed in order to supply the motivation for the development of this technology. A survey of current reaction rate and temporal nuclide inventory techniques is then provided to offer justification for the depletion strategy applied within MCNPX. The MCNPX depletion strategy is then dissected and each code feature is detailed chronicling the methodology development from the original linking of MONTEBURNS and MCNP to the most recent public release of the integrated capability (MCNPX 2.6.F). Calculation results of the OECD/NEA Phase IB benchmark, H. B. Robinson benchmark and OECD/NEA Phase IVB are then provided. The acceptable results of these calculations offer sufficient confidence in the predictive capability of the MCNPX depletion method. This capability sets up a significant foundation, in a well established

  6. The depletion of sodium nitrite by lactic acid bacteria isolated from kimchi.

    PubMed

    Oh, Chang-Kyung; Oh, Myung-Chul; Kim, Soo-Hyun

    2004-01-01

    Nitrites, whether added or naturally occurring in foods, are potential carcinogens, and controlling their concentrations is important for maintaining a safe food supply. In this study we investigated the depletion of sodium nitrite (150 microg/mL) during the fermentation in Lactobacilli MRS broth at 5, 10, 15, 20, 25, 30, and 36 degrees C by lactic acid bacteria (LAB-A, -B, -C, and -D) isolated from kimchi and Leuconostoc mesenteroides strain KCTC3100. The four species of lactic acid bacteria isolated from kimchi were identified as L. mesenteroides, and all produced depletion of less than 20% of sodium nitrite after 10 days of incubation at 5 degrees C. There was less than 40% depletion after 9 days at 10 degrees C, 86.4-92.8% after 7 days at 15 degrees C, 81.4-87.8% after 4 days and more than 90.0% after 5 days at 20 degrees C, 76.3-85.7% after 3 days and more than 90.0% after 5 days at 25 degrees C, and more than 90.0% after 2 days at 30 and 36 degrees C. The depletion by LAB isolates was similar or higher than that by L. mesenteroides strain KCTC3100, and in particular, the LAB-D strain showed the highest depletion effect of all the strains tested, up to 15 degrees C. From these results, the strains isolated from kimchi were very effective for the depletion of sodium nitrite at high temperature, and all sodium nitrite was depleted at the initial period of incubation (1-2 days) at 30 and 36 degrees C. But as the temperature was lowered, the depletion effect of sodium nitrite was decreased in all the strains tested from kimchi. This illustrates that the depletion of nitrite by each strain is subject to the influence of temperatures.

  7. Calcium depletion in a Southeastern United States forest ecosystem

    USGS Publications Warehouse

    Huntington, T.G.; Hooper, R.P.; Johnson, C.E.; Aulenbach, Brent T.; Cappellato, R.; Blum, A.E.

    2000-01-01

    Forest soil Ca depletion through leaching and vegetation uptake may threaten long-term sustainability of forest productivity in the southeastern USA. This study was conducted to assess Ca pools and fluxes in a representative southern Piedmont forest to determine the soil Ca depletion rate. Soil Ca storage, Ca inputs in atmospheric deposition, and outputs in soil leaching and vegetation uptake were investigated at the Panola Mountain Research Watershed (PMRW) near Atlanta, GA. Average annual outputs of 12.3 kg ha-1 yr-1 in uptake into merchantable wood and 2.71 kg ha-1 yr-1 soil leaching exceeded inputs in atmospheric deposition of 2.24 kg ha-1 yr-1. The annual rate of Ca uptake into merchantable wood exceeds soil leaching losses by a factor of more than five. The potential for primary mineral weathering to provide a substantial amount of Ca inputs is low. Estimates of Ca replenishment through mineral weathering in the surface 1 m of soil and saprolite was estimated to be 0.12 kg ha-1 yr-1. The weathering rate in saprolite and partially weathered bedrock below the surface 1 m is similarly quite low because mineral Ca is largely depleted. The soil Ca depletion rate at PMRW is estimated to be 12.7 kg ha-1 yr-1. At PMRW and similar hardwood-dominated forests in the Piedmont physiographic province, Ca depletion will probably reduce soil reserves to less than the requirement for a merchantable forest stand in ???80 yr. This assessment and comparable analyses at other southeastern USA forest sites suggests that there is a strong potential for a regional problem in forest nutrition in the long term.Forest soil Ca depletion through leaching and vegetation uptake may threaten long-term sustainability of forest productivity in the southeastern USA. This study was conducted to assess Ca pools and fluxes in a representative southern Piedmont forest to determine the soil Ca depletion rate. Soil Ca storage, Ca inputs in atmospheric deposition, and outputs in soil leaching and

  8. Rhenium Disulfide Depletion-Load Inverter

    NASA Astrophysics Data System (ADS)

    McClellan, Connor; Corbet, Chris; Rai, Amritesh; Movva, Hema C. P.; Tutuc, Emanuel; Banerjee, Sanjay K.

    2015-03-01

    Many semiconducting Transition Metal Dichalcogenide (TMD) materials have been effectively used to create Field-Effect Transistor (FET) devices but have yet to be used in logic designs. We constructed a depletion-load voltage inverter using ultrathin layers of Rhenium Disulfide (ReS2) as the semiconducting channel. This ReS2 inverter was fabricated on a single micromechanically-exfoliated flake of ReS2. Electron beam lithography and physical vapor deposition were used to construct Cr/Au electrical contacts, an Alumina top-gate dielectric, and metal top-gate electrodes. By using both low (Aluminum) and high (Palladium) work-function metals as two separate top-gates on a single ReS2 flake, we create a dual-gated depletion mode (D-mode) and enhancement mode (E-mode) FETs in series. Both FETs displayed current saturation in the output characteristics as a result of the FET ``pinch-off'' mechanism and On/Off current ratios of 105. Field-effect mobilities of 23 and 17 cm2V-1s-1 and subthreshold swings of 97 and 551 mV/decade were calculated for the E-mode and D-mode FETs, respectively. With a supply voltage of 1V, at low/negative input voltages the inverter output was at a high logic state of 900 mV. Conversely with high/positive input voltages, the inverter output was at a low logic state of 500 mV. The inversion of the input signal demonstrates the potential for using ReS2 in future integrated circuit designs and the versatility of depletion-load logic devices for TMD research. NRI SWAN Center and ARL STTR Program.

  9. Effect of depletion rate on solution gas drive in shale

    NASA Astrophysics Data System (ADS)

    Zhang, Mingshan; Sang, Qian; Gong, Houjian; Li, Yajun; Dong, Mingzhe

    2018-01-01

    Solution gas drive process has been studied extensively in sand rocks and heavy oil reservoirs for a long time. Oil recovery is affected by several factors, such as depletion rate, initial GOR (gas oil ratio), oil viscosity, and temperature and so on. Before the solution gas drive tests, elastic drive without dissolved gas was carried out as a reference, which shows a limited oil recovery. Solution gas drive experiments were conducted in shale to study oil recovery with various depletion rates. Results show that oil recovery increases with the decrease of depletion rates because of the low permeability and desorption of methane.

  10. Depleted Uranium Uses Research and Development

    Science.gov Websites

    Documents News FAQs Internet Resources Glossary Home » DU Uses Depleted Uranium Uses Research & Uses | DUF6 Management | DUF6 Conversion Facility EISs | Documents News | FAQs | Internet Resources

  11. Electromagnetic ion cyclotron waves observed in the plasma depletion layer

    NASA Technical Reports Server (NTRS)

    Anderson, B. J.; Fuselier, S. A.; Murr, D.

    1991-01-01

    Observations from AMPTE/CCE in the earth's magnetosheath on October 5, 1984 are presented to illustrate 0.1 - 4.0 Hz magnetic field pulsations in the subsolar plasma depletion layer (PDL) for northward sheath field during a magnetospheric compression. The PDL is unambiguously identified by comparing CCE data with data from IRM in the upstream solar wind. Pulsations in the PDL are dominated by transverse waves with F/F(H+) 1.0 or less and a slot in spectral power at F/F(H+) = 0.5. The upper branch is left hand polarized while the lower branch is linearly polarized. In the sheath the proton temperature anisotropy is about 0.6 but it is about 1.7 in the PDL during wave occurrence. The properties and correlation of waves with increased anisotropy indicate that they are electromagnetic ion cyclotron waves.

  12. Simulation of Halocarbon Production and Emissions and Effects on Ozone Depletion

    PubMed

    Holmes; Ellis

    1997-09-01

    / This paper describes an integrated model that simulates future halocarbon production/emissions and potential ozone depletion. Applications and historical production levels for various halocarbons are discussed first. A framework is then presented for modeling future halocarbon impacts incorporating differences in underlying demands, applications, regulatory mandates, and environmental characteristics. The model is used to simulate the potential impacts of several prominent issues relating to halocarbon production, regulation, and environmental interactions, notably: changes in agricultural methyl bromide use, increases in effectiveness of bromine for ozone depletion, modifications to the elimination schedule for HCFCs, short-term expansion of CFC demand in low use compliance countries, and delays in Russian Federation compliance. Individually, each issue does not unequivocally represent a significant likely increase in long-term atmospheric halogen loading and stratospheric ozone depletion. In combination, however, these impacts could increase peak halogen concentrations and long-term integral halogen loading, resulting in higher levels of stratospheric ozone depletion and longer exposure to increased levels of UV radiation.KEY WORDS: Halocarbons; Ozone depletion; Montreal Protocol; Integrated assessment

  13. Effectiveness of pulmonary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and without global fat-free mass depletion.

    PubMed

    Berton, Danilo C; Silveira, Leonardo; Da Costa, Cassia C; De Souza, Rafael Machado; Winter, Claudia D; Zimermann Teixeira, Paulo José

    2013-08-01

    To investigate the effectiveness of pulmonary rehabilitation (PR) in exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD) with and without global fat-free mass (FFM) depletion. Retrospective case-control. Outpatient clinic, university center. COPD patients (N=102) that completed PR were initially evaluated. PR including whole-body and weight training for 12 weeks, 3 times per week. St. George Respiratory Questionnaire (SGRQ), 6-minute walk distance (6MWD), and FFM evaluation applied before and after PR. Patients were stratified according to their FFM status measured by bioelectric impedance. They were considered depleted if the FFM index was ≤ 15 kg/m(2) in women and ≤ 16 kg/m(2) in men. From the initial sample, all depleted patients (n=31) composed the FFM depleted group. It was composed predominantly by women (68%) with a mean age ± SD of 64.4 ± 7.3 years and a forced expiratory volume in 1 second of 33.6%=-13.2% predicted. Paired for sex and age, 31 nondepleted patients were selected from the initial sample to compose the nondepleted group. Improvement in the 6MWD was similar in these 2 groups after PR. Both groups improved SGRQ scores, although the observed power was small and did not allow adequate comparison between depleted and nondepleted patients. There was no difference between groups in weight change, whereas FFM tended to be greater in depleted patients. This increase had no correlation with the 6MWD or the SGRQ. Benefits of PR to exercise capacity were similar comparing FFM depleted and nondepleted COPD patients. Although FFM change tended to be greater in depleted patients, this increase had no definite relation with clinical outcomes. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  14. Effects of developer depletion on image quality of Kodak Insight and Ektaspeed Plus films.

    PubMed

    Casanova, M S; Casanova, M L S; Haiter-Neto, F

    2004-03-01

    To evaluate the effect of processing solution depletion on the image quality of F-speed dental X-ray film (Insight), compared with Ektaspeed Plus. The films were exposed with a phantom and developed in manual and automatic conditions, in fresh and progressively depleted solutions. The comparison was based on densitometric analysis and subjective appraisal. The processing solution depletion presented a different behaviour depending on whether manual or automatic technique was used. The films were distinctly affected by depleted processing solutions. The developer depletion was faster in automatic than manual conditions. Insight film was more resistant than Ektaspeed Plus to the effects of processing solution depletion. In the present study there was agreement between the objective and subjective appraisals.

  15. Induced nanoparticle aggregation for short nucleic acid quantification by depletion isotachophoresis.

    PubMed

    Marczak, Steven; Senapati, Satyajyoti; Slouka, Zdenek; Chang, Hsueh-Chia

    2016-12-15

    A rapid (<20min) gel-membrane biochip platform for the detection and quantification of short nucleic acids is presented based on a sandwich assay with probe-functionalized gold nanoparticles and their separation into concentrated bands by depletion-generated gel isotachophoresis. The platform sequentially exploits the enrichment and depletion phenomena of an ion-selective cation-exchange membrane created under an applied electric field. Enrichment is used to concentrate the nanoparticles and targets at a localized position at the gel-membrane interface for rapid hybridization. The depletion generates an isotachophoretic zone without the need for different conductivity buffers, and is used to separate linked nanoparticles from isolated ones in the gel medium and then by field-enhanced aggregation of only the linked particles at the depletion front. The selective field-induced aggregation of the linked nanoparticles during the subsequent depletion step produces two lateral-flow like bands within 1cm for easy visualization and quantification as the aggregates have negligible electrophoretic mobility in the gel and the isolated nanoparticles are isotachophoretically packed against the migrating depletion front. The detection limit for 69-base single-stranded DNA targets is 10 pM (about 10 million copies for our sample volume) with high selectivity against nontargets and a three decade linear range for quantification. The selectivity and signal intensity are maintained in heterogeneous mixtures where the nontargets outnumber the targets 10,000 to 1. The selective field-induced aggregation of DNA-linked nanoparticles at the ion depletion front is attributed to their trailing position at the isotachophoretic front with a large field gradient. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. The Stream Depletion Model Paradox and a First Solution

    NASA Astrophysics Data System (ADS)

    Malama, B.

    2017-12-01

    Hitherto, stream depletion models available in the hydrogeology literature use the xed head Dirichletboundary condition at the stream, and as such do not account for groundwater pumping induced streamdrawdown. They simply treat stream depletion as the decrease in stream discharge due capture by pumping,the groundwater that would discharge to the stream without pumping. We refer to this model predictedstream depletion without stream drawdown as the depletion paradox. It is intuitively clear, however, thatadverse impacts of long-term groundwater abstraction in the neighborhood of a stream include streamdrawdown, which has led to many a dry streambed in the American west and other arid regions. Streamdrawdown is especially acute for low stream ows. A mathematical model that allows for transient streamdrawdown is proposed by introducing the concept of stream storage. The model simply extends the constanthead model at the stream by including a mass-balance condition. The model is developed for a fullypenetrating stream and groundwater abstraction in a conned aquifer. The dependence of model predictedstream depletion and drawdown on stream storage, streambed conductance, aquifer anisotropy, and radialdistance to the pumping well is evaluated. The model is shown to reduce to that of Hantush in the limitas stream storage becomes innitely large, and to the Theis solution with a no- ow boundary at the streamlocation when stream storage gets vanishingly small. The results suggest that using xed stream stage modelsleads to an underestimation the late-time aquifer drawdwon response to pumping in the neighborhood of astream because it correspond to innite stream storage. This is especially critical for management of surfacewater and groundwater resources in systems subjected to prolonged groundwater abstraction and measurablestream drawdown. The model also shows a maximum stream depletion rate, beyond which stream ow to thewell diminishes and eventually vanishes. This suggests

  17. A suggestion to improve a day keeps your depletion away: Examining promotive and prohibitive voice behaviors within a regulatory focus and ego depletion framework.

    PubMed

    Lin, Szu-Han Joanna; Johnson, Russell E

    2015-09-01

    One way that employees contribute to organizational effectiveness is by expressing voice. They may offer suggestions for how to improve the organization (promotive voice behavior), or express concerns to prevent harmful events from occurring (prohibitive voice behavior). Although promotive and prohibitive voices are thought to be distinct types of behavior, very little is known about their unique antecedents and consequences. In this study we draw on regulatory focus and ego depletion theories to derive a theoretical model that outlines a dynamic process of the antecedents and consequences of voice behavior. Results from 2 multiwave field studies revealed that promotion and prevention foci have unique ties to promotive and prohibitive voice, respectively. Promotive and prohibitive voice, in turn, were associated with decreases and increases, respectively, in depletion. Consistent with the dynamic nature of self-control, depletion was associated with reductions in employees' subsequent voice behavior, regardless of the type of voice (promotive or prohibitive). Results were consistent across 2 studies and remained even after controlling for other established antecedents of voice and alternative mediating mechanisms beside depletion. (c) 2015 APA, all rights reserved).

  18. 48 CFR 211.271 - Elimination of use of class I ozone-depleting substances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... class I ozone-depleting substances. 211.271 Section 211.271 Federal Acquisition Regulations System... Using and Maintaining Requirements Documents 211.271 Elimination of use of class I ozone-depleting substances. See subpart 223.8 for restrictions on contracting for ozone-depleting substances. [70 FR 73150...

  19. 48 CFR 211.271 - Elimination of use of class I ozone-depleting substances.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... class I ozone-depleting substances. 211.271 Section 211.271 Federal Acquisition Regulations System... Using and Maintaining Requirements Documents 211.271 Elimination of use of class I ozone-depleting substances. See subpart 223.8 for restrictions on contracting for ozone-depleting substances. [70 FR 73150...

  20. 48 CFR 211.271 - Elimination of use of class I ozone-depleting substances.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... class I ozone-depleting substances. 211.271 Section 211.271 Federal Acquisition Regulations System... Using and Maintaining Requirements Documents 211.271 Elimination of use of class I ozone-depleting substances. See subpart 223.8 for restrictions on contracting for ozone-depleting substances. [70 FR 73150...

  1. 48 CFR 211.271 - Elimination of use of class I ozone-depleting substances.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... class I ozone-depleting substances. 211.271 Section 211.271 Federal Acquisition Regulations System... Using and Maintaining Requirements Documents 211.271 Elimination of use of class I ozone-depleting substances. See subpart 223.8 for restrictions on contracting for ozone-depleting substances. [70 FR 73150...

  2. 48 CFR 211.271 - Elimination of use of class I ozone-depleting substances.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... class I ozone-depleting substances. 211.271 Section 211.271 Federal Acquisition Regulations System... Using and Maintaining Requirements Documents 211.271 Elimination of use of class I ozone-depleting substances. See subpart 223.8 for restrictions on contracting for ozone-depleting substances. [70 FR 73150...

  3. Muscle Mass Depletion Associated with Poor Outcome of Sepsis in the Emergency Department.

    PubMed

    Lee, YoonJe; Park, Hyun Kyung; Kim, Won Young; Kim, Myung Chun; Jung, Woong; Ko, Byuk Sung

    2018-05-08

    Muscle mass depletion has been suggested to predict morbidity and mortality in various diseases. However, it is not well known whether muscle mass depletion is associated with poor outcome in sepsis. We hypothesized that muscle mass depletion is associated with poor outcome in sepsis. Retrospective observational study was conducted in an emergency department during a 9-year period. Medical records of 627 patients with sepsis were reviewed. We divided the patients into 2 groups according to 28-day mortality and compared the presence of muscle mass depletion assessed by the cross-sectional area of the psoas muscle at the level of the third lumbar vertebra on abdomen CT scans. Univariate and multivariate logistic regression analyses were conducted to examine the association of scarcopenia on the outcome of sepsis. A total of 274 patients with sepsis were finally included in the study: 45 (16.4%) did not survive on 28 days and 77 patients (28.1%) were identified as having muscle mass depletion. The presence of muscle mass depletion was independently associated with 28-day mortality on multivariate logistic analysis (OR 2.79; 95% CI 1.35-5.74, p = 0.01). Muscle mass depletion evaluated by CT scan was associated with poor outcome of sepsis patients. Further studies on the appropriateness of specific treatment for muscle mass depletion with sepsis are needed. © 2018 S. Karger AG, Basel.

  4. Terrestrial Ozone Depletion Due to a Milky Way Gamma-Ray Burst

    NASA Technical Reports Server (NTRS)

    Thomas, Brian C.; Jackman, Charles H.; Melott, Adrian L.; Laird, Claude M.; Stolarski, Richard S.; Gehrels, Neil; Cannizzo, John K.; Hogan, Daniel P.

    2005-01-01

    Based on cosmological rates, it is probable that at least once in the last Gy the Earth has been irradiated by a gamma-ray burst in our Galaxy from within 2 kpc. Using a two-dimensional atmospheric model we have computed the effects upon the Earth's atmosphere of one such burst. A ten second burst delivering 100 kJ/sq m to the Earth results in globally averaged ozone depletion of 35%, with depletion reaching 55% at some latitudes. Significant global depletion persists for over 5 years after the burst. This depletion would have dramatic implications for life since a 50% decrease in ozone column density results in approximately three times the normal UVB flux. Widespread extinctions are likely, based on extrapolation from UVB sensitivity of modern organisms.

  5. Observations and Simulations of Formation of Broad Plasma Depletions Through Merging Process

    NASA Technical Reports Server (NTRS)

    Huang, Chao-Song; Retterer, J. M.; Beaujardiere, O. De La; Roddy, P. A.; Hunton, D.E.; Ballenthin, J. O.; Pfaff, Robert F.

    2012-01-01

    Broad plasma depletions in the equatorial ionosphere near dawn are region in which the plasma density is reduced by 1-3 orders of magnitude over thousands of kilometers in longitude. This phenomenon is observed repeatedly by the Communication/Navigation Outage Forecasting System (C/NOFS) satellite during deep solar minimum. The plasma flow inside the depletion region can be strongly upward. The possible causal mechanism for the formation of broad plasma depletions is that the broad depletions result from merging of multiple equatorial plasma bubbles. The purpose of this study is to demonstrate the feasibility of the merging mechanism with new observations and simulations. We present C/NOFS observations for two cases. A series of plasma bubbles is first detected by C/NOFS over a longitudinal range of 3300-3800 km around midnight. Each of the individual bubbles has a typical width of approx 100 km in longitude, and the upward ion drift velocity inside the bubbles is 200-400 m/s. The plasma bubbles rotate with the Earth to the dawn sector and become broad plasma depletions. The observations clearly show the evolution from multiple plasma bubbles to broad depletions. Large upward plasma flow occurs inside the depletion region over 3800 km in longitude and exists for approx 5 h. We also present the numerical simulations of bubble merging with the physics-based low-latitude ionospheric model. It is found that two separate plasma bubbles join together and form a single, wider bubble. The simulations show that the merging process of plasma bubbles can indeed occur in incompressible ionospheric plasma. The simulation results support the merging mechanism for the formation of broad plasma depletions.

  6. High-resolution broadband spectroscopy using externally dispersed interferometry at the Hale telescope: Part 1, data analysis and results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Erskine, David J.; Edelstein, Jerry; Wishnow, Edward H.

    High-resolution broadband spectroscopy at near-infrared wavelengths (950 to 2450 nm) has been performed using externally dispersed interferometry (EDI) at the Hale telescope at Mt. Palomar. Observations of stars were performed with the “TEDI” interferometer mounted within the central hole of the 200-in. primary mirror in series with the comounted TripleSpec near-infrared echelle spectrograph. These are the first multidelay EDI demonstrations on starlight, as earlier measurements used a single delay or laboratory sources. We demonstrate very high (10×) resolution boost, from original 2700 to 27,000 with current set of delays (up to 3 cm), well beyond the classical limits enforced bymore » the slit width and detector pixel Nyquist limit. Significantly, the EDI used with multiple delays rather than a single delay as used previously yields an order of magnitude or more improvement in the stability against native spectrograph point spread function (PSF) drifts along the dispersion direction. We observe a dramatic (20×) reduction in sensitivity to PSF shift using our standard processing. A recently realized method of further reducing the PSF shift sensitivity to zero is described theoretically and demonstrated in a simple simulation which produces a 350× times reduction. We demonstrate superb rejection of fixed pattern noise due to bad detector pixels—EDI only responds to changes in pixel intensity synchronous to applied dithering. This part 1 describes data analysis, results, and instrument noise. Lastly, a section on theoretical photon limited sensitivity is in a companion paper, part 2.« less

  7. High-resolution broadband spectroscopy using externally dispersed interferometry at the Hale telescope: Part 1, data analysis and results

    DOE PAGES

    Erskine, David J.; Edelstein, Jerry; Wishnow, Edward H.; ...

    2016-05-27

    High-resolution broadband spectroscopy at near-infrared wavelengths (950 to 2450 nm) has been performed using externally dispersed interferometry (EDI) at the Hale telescope at Mt. Palomar. Observations of stars were performed with the “TEDI” interferometer mounted within the central hole of the 200-in. primary mirror in series with the comounted TripleSpec near-infrared echelle spectrograph. These are the first multidelay EDI demonstrations on starlight, as earlier measurements used a single delay or laboratory sources. We demonstrate very high (10×) resolution boost, from original 2700 to 27,000 with current set of delays (up to 3 cm), well beyond the classical limits enforced bymore » the slit width and detector pixel Nyquist limit. Significantly, the EDI used with multiple delays rather than a single delay as used previously yields an order of magnitude or more improvement in the stability against native spectrograph point spread function (PSF) drifts along the dispersion direction. We observe a dramatic (20×) reduction in sensitivity to PSF shift using our standard processing. A recently realized method of further reducing the PSF shift sensitivity to zero is described theoretically and demonstrated in a simple simulation which produces a 350× times reduction. We demonstrate superb rejection of fixed pattern noise due to bad detector pixels—EDI only responds to changes in pixel intensity synchronous to applied dithering. This part 1 describes data analysis, results, and instrument noise. Lastly, a section on theoretical photon limited sensitivity is in a companion paper, part 2.« less

  8. Impact of Wildfire Emissions on Chloride and Bromide Depletion in Marine Aerosol Particles.

    PubMed

    Braun, Rachel A; Dadashazar, Hossein; MacDonald, Alexander B; Aldhaif, Abdulamonam M; Maudlin, Lindsay C; Crosbie, Ewan; Aghdam, Mojtaba Azadi; Hossein Mardi, Ali; Sorooshian, Armin

    2017-08-15

    This work examines particulate chloride (Cl - ) and bromide (Br - ) depletion in marine aerosol particles influenced by wildfires at a coastal California site in the summers of 2013 and 2016. Chloride exhibited a dominant coarse mode due to sea salt influence, with substantially diminished concentrations during fire periods as compared to nonfire periods. Bromide exhibited a peak in the submicrometer range during fire and nonfire periods, with an additional supermicrometer peak in the latter periods. Chloride and Br - depletions were enhanced during fire periods as compared to nonfire periods. The highest observed %Cl - depletion occurred in the submicrometer range, with maximum values of 98.9% (0.32-0.56 μm) and 85.6% (0.56-1 μm) during fire and nonfire periods, respectively. The highest %Br - depletion occurred in the supermicrometer range during fire and nonfire periods with peak depletion between 1.8-3.2 μm (78.8% and 58.6%, respectively). When accounting for the neutralization of sulfate by ammonium, organic acid particles showed the greatest influence on Cl - depletion in the submicrometer range. These results have implications for aerosol hygroscopicity and radiative forcing in areas with wildfire influence owing to depletion effects on composition.

  9. Investigation of veritcal graded channel doping in nanoscale fully-depleted SOI-MOSFET

    NASA Astrophysics Data System (ADS)

    Ramezani, Zeinab; Orouji, Ali A.

    2016-10-01

    For achieving reliable transistor, we investigate an amended channel doping (ACD) engineering which improves the electrical and thermal performances of fully-depleted silicon-on-insulator (SOI) MOSFET. We have called the proposed structure with the amended channel doping engineering as ACD-SOI structure and compared it with a conventional fully-depleted SOI MOSFET (C-SOI) with uniform doping distribution using 2-D ATLAS simulator. The amended channel doping is a vertical graded doping that is distributed from the surface of structure with high doping density to the bottom of channel, near the buried oxide, with low doping density. Short channel effects (SCEs) and leakage current suppress due to high barrier height near the source region and electric field modification in the ACD-SOI in comparison with the C-SOI structure. Furthermore, by lower electric field and electron temperature near the drain region that is the place of hot carrier generation, we except the improvement of reliability and gate induced drain lowering (GIDL) in the proposed structure. Undesirable Self heating effect (SHE) that become a critical challenge for SOI MOSFETs is alleviated in the ACD-SOI structure because of utilizing low doping density near the buried oxide. Thus, refer to accessible results, the ACD-SOI structure with graded distribution in vertical direction is a reliable device especially in low power and high temperature applications.

  10. Renal Cortical Pyruvate Depletion during AKI

    PubMed Central

    Johnson, Ali C.M.; Becker, Kirsten

    2014-01-01

    Pyruvate is a key intermediary in energy metabolism and can exert antioxidant and anti-inflammatory effects. However, the fate of pyruvate during AKI remains unknown. Here, we assessed renal cortical pyruvate and its major determinants (glycolysis, gluconeogenesis, pyruvate dehydrogenase [PDH], and H2O2 levels) in mice subjected to unilateral ischemia (15–60 minutes; 0–18 hours of vascular reflow) or glycerol-induced ARF. The fate of postischemic lactate, which can be converted back to pyruvate by lactate dehydrogenase, was also addressed. Ischemia and glycerol each induced persistent pyruvate depletion. During ischemia, decreasing pyruvate levels correlated with increasing lactate levels. During early reperfusion, pyruvate levels remained depressed, but lactate levels fell below control levels, likely as a result of rapid renal lactate efflux. During late reperfusion and glycerol-induced AKI, pyruvate depletion corresponded with increased gluconeogenesis (pyruvate consumption). This finding was underscored by observations that pyruvate injection increased renal cortical glucose content in AKI but not normal kidneys. AKI decreased PDH levels, potentially limiting pyruvate to acetyl CoA conversion. Notably, pyruvate therapy mitigated the severity of AKI. This renoprotection corresponded with increases in cytoprotective heme oxygenase 1 and IL-10 mRNAs, selective reductions in proinflammatory mRNAs (e.g., MCP-1 and TNF-α), and improved tissue ATP levels. Paradoxically, pyruvate increased cortical H2O2 levels. We conclude that AKI induces a profound and persistent depletion of renal cortical pyruvate, which may induce additional injury. PMID:24385590

  11. The Case of Ozone Depletion

    NASA Technical Reports Server (NTRS)

    Lambright, W. Henry

    2005-01-01

    While the National Aeronautics and Space Administration (NASA) is widely perceived as a space agency, since its inception NASA has had a mission dedicated to the home planet. Initially, this mission involved using space to better observe and predict weather and to enable worldwide communication. Meteorological and communication satellites showed the value of space for earthly endeavors in the 1960s. In 1972, NASA launched Landsat, and the era of earth-resource monitoring began. At the same time, in the late 1960s and early 1970s, the environmental movement swept throughout the United States and most industrialized countries. The first Earth Day event took place in 1970, and the government generally began to pay much more attention to issues of environmental quality. Mitigating pollution became an overriding objective for many agencies. NASA's existing mission to observe planet Earth was augmented in these years and directed more toward environmental quality. In the 1980s, NASA sought to plan and establish a new environmental effort that eventuated in the 1990s with the Earth Observing System (EOS). The Agency was able to make its initial mark via atmospheric monitoring, specifically ozone depletion. An important policy stimulus in many respects, ozone depletion spawned the Montreal Protocol of 1987 (the most significant international environmental treaty then in existence). It also was an issue critical to NASA's history that served as a bridge linking NASA's weather and land-resource satellites to NASA s concern for the global changes affecting the home planet. Significantly, as a global environmental problem, ozone depletion underscored the importance of NASA's ability to observe Earth from space. Moreover, the NASA management team's ability to apply large-scale research efforts and mobilize the talents of other agencies and the private sector illuminated its role as a lead agency capable of crossing organizational boundaries as well as the science-policy divide.

  12. The association between controlled interpersonal affect regulation and resource depletion.

    PubMed

    Martínez-Íñigo, David; Poerio, Giulia Lara; Totterdell, Peter

    2013-07-01

    This investigation focuses on what occurs to individuals' self-regulatory resource during controlled Interpersonal Affect Regulation (IAR) which is the process of deliberately influencing the internal feeling states of others. Combining the strength model of self-regulation and the resources conservation model, the investigation tested whether: (1) IAR behaviors are positively related to ego-depletion because goal-directed behaviors demand self-regulatory processes, and (2) the use of affect-improving strategies benefits from a source of resource-recovery because it initiates positive feedback from targets, as proposed from a resource-conservation perspective. To test this, a lab study based on an experimental dual-task paradigm using a sample of pairs of friends in the UK and a longitudinal field study of a sample of healthcare workers in Spain were conducted. The experimental study showed a depleting effect of interpersonal affect-improving IAR on a subsequent self-regulation task. The field study showed that while interpersonal affect-worsening was positively associated with depletion, as indicated by the level of emotional exhaustion, interpersonal affect-improving was only associated with depletion after controlling for the effect of positive feedback from clients. The findings indicate that IAR does have implications for resource depletion, but that social reactions play a role in the outcome. © 2013 The Authors. Applied Psychology: Health and Well-Being © 2013 The International Association of Applied Psychology.

  13. Zn precipitation and Li depletion in Zn implanted ZnO

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chan, K. S.; Jagadish, C.; Wong-Leung, J., E-mail: jenny.wongleung@anu.edu.au

    2016-07-11

    Ion implantation of Zn substituting elements in ZnO has been shown to result in a dramatic Li depletion of several microns in hydrothermally grown ZnO. This has been ascribed to a burst of mobile Zn interstials. In this study, we seek to understand the reason behind this interstitial mediated transient enhanced diffusion in Li-containing ZnO samples after Zn implantation. ZnO wafers were implanted with Zn to two doses, 5 × 10{sup 15} cm{sup −2} and 1 × 10{sup 17} cm{sup −2}. Secondary ion mass spectrometry was carried out to profile the Li depletion depth for different annealing temperatures between 600 and 800 °C. The 800 °C annealing hadmore » the most significant Li depletion of close to 60 μm. Transmission electron microscopy (TEM) was carried out in selected samples to identify the reason behind the Li depletion. In particular, TEM investigations of samples annealed at 750 °C show significant Zn precipitation just below the depth of the projected range of the implanted ions. We propose that the Zn precipitation is indicative of Zn supersaturation. Both the Li depletion and Zn precipitation are competing synchronous processes aimed at reducing the excess Zn interstitials.« less

  14. Producing, Importing, and Exporting Ozone-Depleting Substances

    EPA Pesticide Factsheets

    Overview page provides links to information on producing, importing, and exporting ozone-depleting substances, including information about the HCFC allowance system, importing, labeling, recordkeeping and reporting.

  15. Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis.

    PubMed

    Sefia, Eseberuo; Pryce, Gareth; Meier, Ute-Christiane; Giovannoni, Gavin; Baker, David

    2017-05-01

    Multiple sclerosis (MS) is often considered to be a CD4, T cell-mediated disease. This is largely based on the capacity of CD4 T cells to induce relapsing experimental autoimmune encephalomyelitis (EAE) in rodents. However, CD4-depletion using a monoclonal antibody was considered unsuccessful and relapsing MS responds well to B cell depletion via CD20 B cell depleting antibodies. The influence of CD20 B cell depletion in relapsing EAE was assessed. Relapsing EAE was induced in Biozzi ABH mice. These were treated with CD20-specific (18B12) antibody and the influence on CD45RA-B220 B cell depletion and clinical course was analysed. Relapsing EAE in Biozzi ABH failed to respond to the marked B cell depletion induced with a CD20-specific antibody. In contrast to CD20 and CD8-specific antibodies, CD4 T cell depletion inhibited EAE. Spinal cord antigen-induced disease in ABH mice is CD4 T cell-dependent. The lack of influence of CD20 B cell depletion in relapsing EAE, coupled with the relatively marginal and inconsistent results obtained in other mouse studies, suggests that rodents may have limited value in understanding the mechanism occurring following CD20 B cell depletion in humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Both cladribine and alemtuzumab may effect MS via B-cell depletion.

    PubMed

    Baker, David; Herrod, Samuel S; Alvarez-Gonzalez, Cesar; Zalewski, Lukasz; Albor, Christo; Schmierer, Klaus

    2017-07-01

    To understand the efficacy of cladribine (CLAD) treatment in MS through analysis of lymphocyte subsets collected, but not reported, in the pivotal phase III trials of cladribine and alemtuzumab induction therapies. The regulatory submissions of the CLAD Tablets Treating Multiple Sclerosis Orally (CLARITY) (NCT00213135) cladribine and Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis, study one (CARE-MS I) (NCT00530348) alemtuzumab trials were obtained from the European Medicine Agency through Freedom of Information requests. Data were extracted and statistically analyzed. Either dose of cladribine (3.5 mg/kg; 5.25 mg/kg) tested in CLARITY reduced the annualized relapse rate to 0.16-0.18 over 96 weeks, and both doses were similarly effective in reducing the risk of MRI lesions and disability. Surprisingly, however, T-cell depletion was rather modest. Cladribine 3.5 mg/kg depleted CD4 + cells by 40%-45% and CD8 + cells by 15%-30%, whereas alemtuzumab suppressed CD4 + cells by 70%-95% and CD8 + cells by 47%-55%. However, either dose of cladribine induced 70%-90% CD19 + B-cell depletion, similar to alemtuzumab (90%). CD19 + cells slowly repopulated to 15%-25% of baseline before cladribine redosing. However, alemtuzumab induced hyperrepopulation of CD19 + B cells 6-12 months after infusion, which probably forms the substrate for B-cell autoimmunities associated with alemtuzumab. Cladribine induced only modest depletion of T cells, which may not be consistent with a marked influence on MS, based on previous CD4 + T-cell depletion studies. The therapeutic drug-response relationship with cladribine is more consistent with lasting B-cell depletion and, coupled with the success seen with monoclonal CD20 + depletion, suggests that B-cell suppression could be the major direct mechanism of action.

  17. Protection of ATP-Depleted Cells by Impermeant Strychnine Derivatives

    PubMed Central

    Dong, Zheng; Venkatachalam, Manjeri A.; Weinberg, Joel M.; Saikumar, Pothana; Patel, Yogendra

    2001-01-01

    Glycine and structurally related amino acids with activities at chloride channel receptors in the central nervous system also have robust protective effects against cell injury by ATP depletion. The glycine receptor antagonist strychnine shares this protective activity. An essential step toward identification of the molecular targets for these compounds is to determine whether they protect cells through interactions with intracellular targets or with molecules on the outer surface of plasma membranes. Here we report cytoprotection by a cell-impermeant derivative of strychnine. A strychnine-fluorescein conjugate (SF) was synthesized, and impermeability of plasma membranes to this compound was verified by fluorescence confocal microscopy. In an injury model of Madin-Darby canine kidney cells, ATP depletion led to lactate dehydrogenase release. SF prevented lactate dehydrogenase leakage without ameliorating ATP depletion. This was accompanied by preservation of cellular ultrastructure and exclusion of vital dyes. SF protection was also shown for ATP-depleted rat hepatocytes. On the other hand, when a key structural motif in the active site of strychnine was chemically blocked, the SF lost its protective effect, establishing strychnine-related specificity for SF protection. Cytoprotective effects of the cell-impermeant strychnine derivative provide compelling evidence suggesting that molecular targets on the outer surface of plasma membranes may mediate cytoprotection by strychnine and glycine. PMID:11238050

  18. 26 CFR 1.1502-44 - Percentage depletion for independent producers and royalty owners.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Percentage depletion for independent producers...-44 Percentage depletion for independent producers and royalty owners. (a) In general. The sum of the percentage depletion deductions for the taxable year for all oil or gas property owned by all members, plus...

  19. Influence of calcium depletion on iron-binding properties of milk.

    PubMed

    Mittal, V A; Ellis, A; Ye, A; Das, S; Singh, H

    2015-04-01

    We investigated the effects of calcium depletion on the binding of iron in milk. A weakly acidic cation-exchange resin was used to remove 3 different levels (18-22, 50-55, and 68-72%) of calcium from milk. Five levels of iron (5, 10, 15, 20, and 25 mM) were added to each of these calcium-depleted milks (CDM) and the resultant milks were analyzed for particle size, microstructure, and the distribution of protein and minerals between the colloidal and soluble phases. The depletion of calcium affected the distribution of protein and minerals in normal milk. Iron added to normal milk and low-CDM (~20% calcium depletion) bound mainly to the colloidal phase (material sedimented at 100,000 × g for 1 h at 20 °C), with little effect on the integrity of the casein micelles. Depletion of ~70% of the calcium from milk resulted in almost complete disintegration of the casein micelles, as indicated by all the protein remaining in the soluble phase upon ultracentrifugation. Addition of up to ~20 mM iron to high CDM resulted in the formation of small fibrous structures that remained in the soluble phase of milk. It appeared that the iron bound to soluble (nonsedimentable) caseins in high-CDM. We observed a decrease in the aqueous phosphorus content of all milks upon iron addition, irrespective of their calcium content. We considered the interaction between aqueous phosphorus and added iron to be responsible for the high iron-binding capacity of the proteins in milk. The soluble protein-iron complexes formed in high-CDM (~70% calcium depletion) could be used as an effective iron fortificant for a range of food products because of their good solubility characteristics. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  20. Tryptophan depletion decreases the recognition of fear in female volunteers.

    PubMed

    Harmer, C J; Rogers, R D; Tunbridge, E; Cowen, P J; Goodwin, G M

    2003-06-01

    Serotonergic processes have been implicated in the modulation of fear conditioning in humans, postulated to occur at the level of the amygdala. The processing of other fear-relevant cues, such as facial expressions, has also been associated with amygdala function, but an effect of serotonin depletion on these processes has not been assessed. The present study investigated the effects of reducing serotonin function, using acute tryptophan depletion, on the recognition of basic facial expressions of emotions in healthy male and female volunteers. A double-blind between-groups design was used, with volunteers being randomly allocated to receive an amino acid drink specifically lacking tryptophan or a control mixture containing a balanced mixture of these amino acids. Participants were given a facial expression recognition task 5 h after drink administration. This task featured examples of six basic emotions (fear, anger, disgust, surprise, sadness and happiness) that had been morphed between each full emotion and neutral in 10% steps. As a control, volunteers were given a famous face classification task matched in terms of response selection and difficulty level. Tryptophan depletion significantly impaired the recognition of fearful facial expressions in female, but not male, volunteers. This was specific since recognition of other basic emotions was comparable in the two groups. There was also no effect of tryptophan depletion on the classification of famous faces or on subjective state ratings of mood or anxiety. These results confirm a role for serotonin in the processing of fear related cues, and in line with previous findings also suggest greater effects of tryptophan depletion in female volunteers. Although acute tryptophan depletion does not typically affect mood in healthy subjects, the present results suggest that subtle changes in the processing of emotional material may occur with this manipulation of serotonin function.

  1. Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum

    PubMed Central

    Kornilov, Roman; Puhka, Maija; Mannerström, Bettina; Hiidenmaa, Hanna; Peltoniemi, Hilkka; Siljander, Pia; Seppänen-Kaijansinkko, Riitta; Kaur, Sippy

    2018-01-01

    ABSTRACT Fetal bovine serum (FBS) is the most commonly used supplement in studies involving cell-culture experiments. However, FBS contains large numbers of bovine extracellular vesicles (EVs), which hamper the analyses of secreted EVs from the cell type of preference and, thus, also the downstream analyses. Therefore, a prior elimination of EVs from FBS is crucial. However, the current methods of EV depletion by ultracentrifugation are cumbersome and the commercial alternatives expensive. In this study, our aim was to develop a protocol to completely deplete EVs from FBS, which may have wide applicability in cell-culture applications. We investigated different EV-depleted FBS prepared by our novel ultrafiltration-based protocol, by conventionally used overnight ultracentrifugation, or commercially available depleted FBS, and compared them with regular FBS. All sera were characterized by nanoparticle tracking analysis, electron microscopy, Western blotting and RNA quantification. Next, adipose-tissue mesenchymal stem cells (AT-MSCs) and cancer cells were grown in the media supplemented with the three different EV-depleted FBS and compared with cells grown in regular FBS media to assess the effects on cell proliferation, stress, differentiation and EV production. The novel ultrafiltration-based protocol depleted EVs from FBS clearly more efficiently than ultracentrifugation and commercial methods. Cell proliferation, stress, differentiation and EV production of AT-MSCs and cancer cell lines were similarly maintained in all three EV-depleted FBS media up to 96 h. In summary, our ultrafiltration protocol efficiently depletes EVs, is easy to use and maintains cell growth and metabolism. Since the method is also cost-effective and easy to standardize, it could be used in a wide range of cell-culture applications helping to increase comparability of EV research results between laboratories. PMID:29410778

  2. Alignment of gold nanorods by angular photothermal depletion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taylor, Adam B.; Chow, Timothy T. Y.; Chon, James W. M., E-mail: jchon@swin.edu.au

    2014-02-24

    In this paper, we demonstrate that a high degree of alignment can be imposed upon randomly oriented gold nanorod films by angular photothermal depletion with linearly polarized laser irradiation. The photothermal reshaping of gold nanorods is observed to follow quadratic melting model rather than the threshold melting model, which distorts the angular and spectral hole created on 2D distribution map of nanorods to be an open crater shape. We have accounted these observations to the alignment procedures and demonstrated good agreement between experiment and simulations. The use of multiple laser depletion wavelengths allowed alignment criteria over a large range ofmore » aspect ratios, achieving 80% of the rods in the target angular range. We extend the technique to demonstrate post-alignment in a multilayer of randomly oriented gold nanorod films, with arbitrary control of alignment shown across the layers. Photothermal angular depletion alignment of gold nanorods is a simple, promising post-alignment method for creating future 3D or multilayer plasmonic nanorod based devices and structures.« less

  3. 26 CFR 52.4681-1 - Taxes imposed with respect to ozone-depleting chemicals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 17 2014-04-01 2014-04-01 false Taxes imposed with respect to ozone-depleting... to ozone-depleting chemicals. (a) Taxes imposed. Sections 4681 and 4682 impose the following taxes with respect to ozone-depleting chemicals (ODCs): (1) Tax on ODCs. Section 4681(a)(1) imposes a tax on...

  4. 26 CFR 52.4681-1 - Taxes imposed with respect to ozone-depleting chemicals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 17 2012-04-01 2012-04-01 false Taxes imposed with respect to ozone-depleting... to ozone-depleting chemicals. (a) Taxes imposed. Sections 4681 and 4682 impose the following taxes with respect to ozone-depleting chemicals (ODCs): (1) Tax on ODCs. Section 4681(a)(1) imposes a tax on...

  5. 26 CFR 52.4681-1 - Taxes imposed with respect to ozone-depleting chemicals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Taxes imposed with respect to ozone-depleting... to ozone-depleting chemicals. (a) Taxes imposed. Sections 4681 and 4682 impose the following taxes with respect to ozone-depleting chemicals (ODCs): (1) Tax on ODCs. Section 4681(a)(1) imposes a tax on...

  6. 26 CFR 52.4681-1 - Taxes imposed with respect to ozone-depleting chemicals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 17 2013-04-01 2013-04-01 false Taxes imposed with respect to ozone-depleting... to ozone-depleting chemicals. (a) Taxes imposed. Sections 4681 and 4682 impose the following taxes with respect to ozone-depleting chemicals (ODCs): (1) Tax on ODCs. Section 4681(a)(1) imposes a tax on...

  7. The influence of ego depletion on sprint start performance in athletes without track and field experience.

    PubMed

    Englert, Chris; Persaud, Brittany N; Oudejans, Raôul R D; Bertrams, Alex

    2015-01-01

    We tested the assumption that ego depletion would affect the sprint start in a sample of N = 38 athletes without track and field experience in an experiment by applying a mixed between- (depletion vs. non-depletion) within- (T1: before manipulation of ego depletion vs. T2: after manipulation of ego depletion) subjects design. We assumed that ego depletion would increase the possibility for a false start, as regulating the impulse to initiate the sprinting movement too soon before the starting signal requires self-control. In line with our assumption, we found a significant interaction as there was only a significant increase in the number of false starts from T1 to T2 for the depletion group while this was not the case for the non-depletion group. We conclude that ego depletion has a detrimental influence on the sprint start in athletes without track and field experience.

  8. The influence of ego depletion on sprint start performance in athletes without track and field experience

    PubMed Central

    Englert, Chris; Persaud, Brittany N.; Oudejans, Raôul R. D.; Bertrams, Alex

    2015-01-01

    We tested the assumption that ego depletion would affect the sprint start in a sample of N = 38 athletes without track and field experience in an experiment by applying a mixed between- (depletion vs. non-depletion) within- (T1: before manipulation of ego depletion vs. T2: after manipulation of ego depletion) subjects design. We assumed that ego depletion would increase the possibility for a false start, as regulating the impulse to initiate the sprinting movement too soon before the starting signal requires self-control. In line with our assumption, we found a significant interaction as there was only a significant increase in the number of false starts from T1 to T2 for the depletion group while this was not the case for the non-depletion group. We conclude that ego depletion has a detrimental influence on the sprint start in athletes without track and field experience. PMID:26347678

  9. Reverse ego-depletion: Acts of self-control can improve subsequent performance in Indian cultural contexts.

    PubMed

    Savani, Krishna; Job, Veronika

    2017-10-01

    The strength model of self-control has been predominantly tested with people from Western cultures. The present research asks whether the phenomenon of ego-depletion generalizes to a culture emphasizing the virtues of exerting mental self-control in everyday life. A pilot study found that whereas Americans tended to believe that exerting willpower on mental tasks is depleting, Indians tended to believe that exerting willpower is energizing. Using dual task ego-depletion paradigms, Studies 1a, 1b, and 1c found reverse ego-depletion among Indian participants, such that participants exhibited better mental self-control on a subsequent task after initially working on strenuous rather than nonstrenuous cognitive tasks. Studies 2 and 3 found that Westerners exhibited the ego-depletion effect whereas Indians exhibited the reverse ego-depletion effect on the same set of tasks. Study 4 documented the causal effect of lay beliefs about whether exerting willpower is depleting versus energizing on reverse ego-depletion with both Indian and Western participants. Together, these studies reveal the underlying basis of the ego-depletion phenomenon in culturally shaped lay theories about willpower. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  10. Comparison of methods for evaluating ground-contact copper preservative depletion

    Treesearch

    Stan Lebow; Steven Halverson

    2008-01-01

    Depletion of the biocide(s) used to treat wood has a major influence on service life and environmental concerns. However, little is known about the extent of depletion from the specific leaching method employed. Wood treated with two types of copper-based preservatives were leached using three different methods: field stakes (American Wood Protection Association (AWPA...

  11. Macroinvertebrate short-term responses to flow variation and oxygen depletion: A mesocosm approach.

    PubMed

    Calapez, Ana R; Branco, Paulo; Santos, José M; Ferreira, Teresa; Hein, Thomas; Brito, António G; Feio, Maria João

    2017-12-01

    In Mediterranean rivers, water scarcity is a key stressor with direct and indirect effects on other stressors, such as water quality decline and inherent oxygen depletion associated with pollutants inputs. Yet, predicting the responses of macroinvertebrates to these stressors combination is quite challenging due to the reduced available information, especially if biotic and abiotic seasonal variations are taken under consideration. This study focused on the response of macroinvertebrates by drift to single and combined effects of water scarcity and dissolved oxygen (DO) depletion over two seasons (winter and spring). A factorial design of two flow velocity levels - regular and low (vL) - with three levels of oxygen depletion - normoxia, medium depletion (dM) and higher depletion (dH) - was carried out in a 5-artificial channels system, in short-term experiments. Results showed that both stressors individually and together had a significant effect on macroinvertebrate drift ratio for both seasons. Single stressor effects showed that macroinvertebrate drift decreased with flow velocity reduction and increased with DO depletion, in both winter and spring experiments. Despite single stressors opposing effects in drift ratio, combined stressors interaction (vL×dM and vL×dH) induced a positive synergistic drift effect for both seasons, but only in winter the drift ratio was different between the levels of DO depletion. Stressors interaction in winter seemed to intensify drift response when reached lower oxygen saturation. Also, drift patterns were different between seasons for all treatments, which may depend on individual's life stage and seasonal behaviour. Water scarcity seems to exacerbate the oxygen depletion conditions resulting into a greater drifting of invertebrates. The potential effects of oxygen depletion should be evaluated when addressing the impacts of water scarcity on river ecosystems, since flow reductions will likely contribute to a higher oxygen

  12. Electrically Heated Testing of the Kilowatt Reactor Using Stirling Technology (KRUSTY) Experiment Using a Depleted Uranium Core

    NASA Technical Reports Server (NTRS)

    Briggs, Maxwell H.; Gibson, Marc A.; Sanzi, James

    2017-01-01

    The Kilopower project aims to develop and demonstrate scalable fission-based power technology for systems capable of delivering 110 kW of electric power with a specific power ranging from 2.5 - 6.5 Wkg. This technology could enable high power science missions or could be used to provide surface power for manned missions to the Moon or Mars. NASA has partnered with the Department of Energys National Nuclear Security Administration, Los Alamos National Labs, and Y-12 National Security Complex to develop and test a prototypic reactor and power system using existing facilities and infrastructure. This technology demonstration, referred to as the Kilowatt Reactor Using Stirling TechnologY (KRUSTY), will undergo nuclear ground testing in the summer of 2017 at the Nevada Test Site. The 1 kWe variation of the Kilopower system was chosen for the KRUSTY demonstration. The concept for the 1 kWe flight system consist of a 4 kWt highly enriched Uranium-Molybdenum reactor operating at 800 degrees Celsius coupled to sodium heat pipes. The heat pipes deliver heat to the hot ends of eight 125 W Stirling convertors producing a net electrical output of 1 kW. Waste heat is rejected using titanium-water heat pipes coupled to carbon composite radiator panels. The KRUSTY test, based on this design, uses a prototypic highly enriched uranium-molybdenum core coupled to prototypic sodium heat pipes. The heat pipes transfer heat to two Advanced Stirling Convertors (ASC-E2s) and six thermal simulators, which simulate the thermal draw of full scale power conversion units. Thermal simulators and Stirling engines are gas cooled. The most recent project milestone was the completion of non-nuclear system level testing using an electrically heated depleted uranium (non-fissioning) reactor core simulator. System level testing at the Glenn Research Center (GRC) has validated performance predictions and has demonstrated system level operation and control in a test configuration that replicates the one

  13. Modeling of the dispersion of depleted uranium aerosol.

    PubMed

    Mitsakou, C; Eleftheriadis, K; Housiadas, C; Lazaridis, M

    2003-04-01

    Depleted uranium is a low-cost radioactive material that, in addition to other applications, is used by the military in kinetic energy weapons against armored vehicles. During the Gulf and Balkan conflicts concern has been raised about the potential health hazards arising from the toxic and radioactive material released. The aerosol produced during impact and combustion of depleted uranium munitions can potentially contaminate wide areas around the impact sites or can be inhaled by civilians and military personnel. Attempts to estimate the extent and magnitude of the dispersion were until now performed by complex modeling tools employing unclear assumptions and input parameters of high uncertainty. An analytical puff model accommodating diffusion with simultaneous deposition is developed, which can provide a reasonable estimation of the dispersion of the released depleted uranium aerosol. Furthermore, the period of the exposure for a given point downwind from the release can be estimated (as opposed to when using a plume model). The main result is that the depleted uranium mass is deposited very close to the release point. The deposition flux at a couple of kilometers from the release point is more than one order of magnitude lower than the one a few meters near the release point. The effects due to uncertainties in the key input variables are addressed. The most influential parameters are found to be atmospheric stability, height of release, and wind speed, whereas aerosol size distribution is less significant. The output from the analytical model developed was tested against the numerical model RPM-AERO. Results display satisfactory agreement between the two models.

  14. Global analysis of depletion and recovery of seabed biota after bottom trawling disturbance.

    PubMed

    Hiddink, Jan Geert; Jennings, Simon; Sciberras, Marija; Szostek, Claire L; Hughes, Kathryn M; Ellis, Nick; Rijnsdorp, Adriaan D; McConnaughey, Robert A; Mazor, Tessa; Hilborn, Ray; Collie, Jeremy S; Pitcher, C Roland; Amoroso, Ricardo O; Parma, Ana M; Suuronen, Petri; Kaiser, Michel J

    2017-08-01

    Bottom trawling is the most widespread human activity affecting seabed habitats. Here, we collate all available data for experimental and comparative studies of trawling impacts on whole communities of seabed macroinvertebrates on sedimentary habitats and develop widely applicable methods to estimate depletion and recovery rates of biota after trawling. Depletion of biota and trawl penetration into the seabed are highly correlated. Otter trawls caused the least depletion, removing 6% of biota per pass and penetrating the seabed on average down to 2.4 cm, whereas hydraulic dredges caused the most depletion, removing 41% of biota and penetrating the seabed on average 16.1 cm. Median recovery times posttrawling (from 50 to 95% of unimpacted biomass) ranged between 1.9 and 6.4 y. By accounting for the effects of penetration depth, environmental variation, and uncertainty, the models explained much of the variability of depletion and recovery estimates from single studies. Coupled with large-scale, high-resolution maps of trawling frequency and habitat, our estimates of depletion and recovery rates enable the assessment of trawling impacts on unprecedented spatial scales.

  15. Global analysis of depletion and recovery of seabed biota after bottom trawling disturbance

    PubMed Central

    Hiddink, Jan Geert; Jennings, Simon; Sciberras, Marija; Szostek, Claire L.; Hughes, Kathryn M.; Ellis, Nick; Rijnsdorp, Adriaan D.; McConnaughey, Robert A.; Mazor, Tessa; Hilborn, Ray; Collie, Jeremy S.; Pitcher, C. Roland; Amoroso, Ricardo O.; Parma, Ana M.; Suuronen, Petri; Kaiser, Michel J.

    2017-01-01

    Bottom trawling is the most widespread human activity affecting seabed habitats. Here, we collate all available data for experimental and comparative studies of trawling impacts on whole communities of seabed macroinvertebrates on sedimentary habitats and develop widely applicable methods to estimate depletion and recovery rates of biota after trawling. Depletion of biota and trawl penetration into the seabed are highly correlated. Otter trawls caused the least depletion, removing 6% of biota per pass and penetrating the seabed on average down to 2.4 cm, whereas hydraulic dredges caused the most depletion, removing 41% of biota and penetrating the seabed on average 16.1 cm. Median recovery times posttrawling (from 50 to 95% of unimpacted biomass) ranged between 1.9 and 6.4 y. By accounting for the effects of penetration depth, environmental variation, and uncertainty, the models explained much of the variability of depletion and recovery estimates from single studies. Coupled with large-scale, high-resolution maps of trawling frequency and habitat, our estimates of depletion and recovery rates enable the assessment of trawling impacts on unprecedented spatial scales. PMID:28716926

  16. Relapse of nephrotic syndrome during post-rituximab peripheral blood B-lymphocyte depletion.

    PubMed

    Sato, Mai; Kamei, Koichi; Ogura, Masao; Ishikura, Kenji; Ito, Shuichi

    2018-02-01

    Rituximab is effective against complicated childhood steroid-dependent nephrotic syndrome (SDNS). Peripheral blood B-lymphocyte (B-cell) depletion is strongly correlated with persistent remission, relapse rarely occurring during B-cell depletion; however, we have encountered several such patients. We retrospectively analyzed the characteristics and clinical course of 82 patients with SDNS treated with rituximab from January 2007 to December 2012 in our institution. Six of 82 patients (7.3%) had relapses during B-cell depletion after receiving rituximab (relapsed group). The remaining 76 patients did not have relapses during B-cell depletion (non-relapsed group). The median time to initial relapse during B-cell depletion was 85 days after receiving rituximab, which is significantly shorter than in the non-relapsed group (410 days, p = 0.0003). The median annual numbers of relapses after receiving rituximab were 2.5 and 0.9 in the relapsed and non-relapsed groups, respectively (p < 0.0001). Five patients in the relapsed group also had a total of 10 relapses after B-cell recovery; their median time from B-cell recovery to initial relapse was significantly shorter than in the non-relapsed group (31 vs. 161 days, p = 0.014). Number of relapses before rituximab, history of steroid resistance, onset age, previous treatment, time to ceasing steroids after rituximab, and duration of B-cell depletion did not differ between the two groups. Relapse during B-cell depletion after receiving rituximab suggests that various pathophysiological mechanisms play a part in childhood nephrotic syndrome.

  17. Woody debris volume depletion through decay: implications for biomass and carbon accounting

    USGS Publications Warehouse

    Fraver, Shawn; Milo, Amy M.; Bradford, John B.; D'Amato, Anthony W.; Kenefic, Laura; Palik, Brian J.; Woodall, Christopher W.; Brissette, John

    2013-01-01

    Woody debris decay rates have recently received much attention because of the need to quantify temporal changes in forest carbon stocks. Published decay rates, available for many species, are commonly used to characterize deadwood biomass and carbon depletion. However, decay rates are often derived from reductions in wood density through time, which when used to model biomass and carbon depletion are known to underestimate rate loss because they fail to account for volume reduction (changes in log shape) as decay progresses. We present a method for estimating changes in log volume through time and illustrate the method using a chronosequence approach. The method is based on the observation, confirmed herein, that decaying logs have a collapse ratio (cross-sectional height/width) that can serve as a surrogate for the volume remaining. Combining the resulting volume loss with concurrent changes in wood density from the same logs then allowed us to quantify biomass and carbon depletion for three study species. Results show that volume, density, and biomass follow distinct depletion curves during decomposition. Volume showed an initial lag period (log dimensions remained unchanged), even while wood density was being reduced. However, once volume depletion began, biomass loss (the product of density and volume depletion) occurred much more rapidly than density alone. At the temporal limit of our data, the proportion of the biomass remaining was roughly half that of the density remaining. Accounting for log volume depletion, as demonstrated in this study, provides a comprehensive characterization of deadwood decomposition, thereby improving biomass-loss and carbon-accounting models.

  18. The Physical Origin of Long Gas Depletion Times in Galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Semenov, Vadim A.; Kravtsov, Andrey V.; Gnedin, Nickolay Y.

    2017-08-18

    We present a model that elucidates why gas depletion times in galaxies are long compared to the time scales of the processes driving the evolution of the interstellar medium. We show that global depletion times are not set by any "bottleneck" in the process of gas evolution towards the star-forming state. Instead, depletion times are long because star-forming gas converts only a small fraction of its mass into stars before it is dispersed by dynamical and feedback processes. Thus, complete depletion requires that gas transitions between star-forming and non-star-forming states multiple times. Our model does not rely on the assumption of equilibrium and can be used to interpret trends of depletion times with the properties of observed galaxies and the parameters of star formation and feedback recipes in galaxy simulations. In particular, the model explains the mechanism by which feedback self-regulates star formation rate in simulations and makes it insensitive to the local star formation efficiency. We illustrate our model using the results of an isolatedmore » $$L_*$$-sized disk galaxy simulation that reproduces the observed Kennicutt-Schmidt relation for both molecular and atomic gas. Interestingly, the relation for molecular gas is close to linear on kiloparsec scales, even though a non-linear relation is adopted in simulation cells. This difference is due to stellar feedback, which breaks the self-similar scaling of the gas density PDF with the average gas surface density.« less

  19. Inflammation Causes Resistance to Anti-CD20-Mediated B Cell Depletion.

    PubMed

    Laws, L H; Parker, C E; Cherala, G; Koguchi, Y; Waisman, A; Slifka, M K; Oberbarnscheidt, M H; Obhrai, J S; Yeung, M Y; Riella, L V

    2016-11-01

    B cells play a central role in antibody-mediated rejection and certain autoimmune diseases. However, B cell-targeted therapy such as anti-CD20 B cell-depleting antibody (aCD20) has yielded mixed results in improving outcomes. In this study, we investigated whether an accelerated B cell reconstitution leading to aCD20 depletion resistance could account for these discrepancies. Using a transplantation model, we found that antigen-independent inflammation, likely through toll-like receptor (TLR) signaling, was sufficient to mitigate B cell depletion. Secondary lymphoid organs had a quicker recovery of B cells when compared to peripheral blood. Inflammation altered the pharmacokinetics (PK) and pharmacodynamics (PD) of aCD20 therapy by shortening drug half-life and accelerating the reconstitution of the peripheral B cell pool by bone marrow-derived B cell precursors. IVIG (intravenous immunoglobulin) coadministration also shortened aCD20 drug half-life and led to accelerated B cell recovery. Repeated aCD20 dosing restored B cell depletion and delayed allograft rejection, especially B cell-dependent, antibody-independent allograft rejection. These data demonstrate the importance of further clinical studies of the PK/PD of monoclonal antibody treatment in inflammatory conditions. The data also highlight the disconnect between B cell depletion on peripheral blood compared to secondary lymphoid organs, the deleterious effect of IVIG when given with aCD20 and the relevance of redosing of aCD20 for effective B cell depletion in alloimmunity. © Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

  20. Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

    PubMed Central

    Nile, Donna L.; Brown, Audrey E.; Kumaheri, Meutia A.; Blair, Helen R.; Heggie, Alison; Miwa, Satomi; Cree, Lynsey M.; Payne, Brendan; Chinnery, Patrick F.; Brown, Louise; Gunn, David A.; Walker, Mark

    2014-01-01

    Type 2 diabetes is characterised by an age-related decline in insulin secretion. We previously identified a 50% age-related decline in mitochondrial DNA (mtDNA) copy number in isolated human islets. The purpose of this study was to mimic this degree of mtDNA depletion in MIN6 cells to determine whether there is a direct impact on insulin secretion. Transcriptional silencing of mitochondrial transcription factor A, TFAM, decreased mtDNA levels by 40% in MIN6 cells. This level of mtDNA depletion significantly decreased mtDNA gene transcription and translation, resulting in reduced mitochondrial respiratory capacity and ATP production. Glucose-stimulated insulin secretion was impaired following partial mtDNA depletion, but was normalised following treatment with glibenclamide. This confirms that the deficit in the insulin secretory pathway precedes K+ channel closure, indicating that the impact of mtDNA depletion is at the level of mitochondrial respiration. In conclusion, partial mtDNA depletion to a degree comparable to that seen in aged human islets impaired mitochondrial function and directly decreased insulin secretion. Using our model of partial mtDNA depletion following targeted gene silencing of TFAM, we have managed to mimic the degree of mtDNA depletion observed in aged human islets, and have shown how this correlates with impaired insulin secretion. We therefore predict that the age-related mtDNA depletion in human islets is not simply a biomarker of the aging process, but will contribute to the age-related risk of type 2 diabetes. PMID:25532126

  1. Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function.

    PubMed

    Nile, Donna L; Brown, Audrey E; Kumaheri, Meutia A; Blair, Helen R; Heggie, Alison; Miwa, Satomi; Cree, Lynsey M; Payne, Brendan; Chinnery, Patrick F; Brown, Louise; Gunn, David A; Walker, Mark

    2014-01-01

    Type 2 diabetes is characterised by an age-related decline in insulin secretion. We previously identified a 50% age-related decline in mitochondrial DNA (mtDNA) copy number in isolated human islets. The purpose of this study was to mimic this degree of mtDNA depletion in MIN6 cells to determine whether there is a direct impact on insulin secretion. Transcriptional silencing of mitochondrial transcription factor A, TFAM, decreased mtDNA levels by 40% in MIN6 cells. This level of mtDNA depletion significantly decreased mtDNA gene transcription and translation, resulting in reduced mitochondrial respiratory capacity and ATP production. Glucose-stimulated insulin secretion was impaired following partial mtDNA depletion, but was normalised following treatment with glibenclamide. This confirms that the deficit in the insulin secretory pathway precedes K+ channel closure, indicating that the impact of mtDNA depletion is at the level of mitochondrial respiration. In conclusion, partial mtDNA depletion to a degree comparable to that seen in aged human islets impaired mitochondrial function and directly decreased insulin secretion. Using our model of partial mtDNA depletion following targeted gene silencing of TFAM, we have managed to mimic the degree of mtDNA depletion observed in aged human islets, and have shown how this correlates with impaired insulin secretion. We therefore predict that the age-related mtDNA depletion in human islets is not simply a biomarker of the aging process, but will contribute to the age-related risk of type 2 diabetes.

  2. Dopaminergic modulation of striatal acetylcholine release in rats depleted of dopamine as neonates.

    PubMed

    Johnson, B J; Bruno, J P

    1995-02-01

    A repeated sessions, in vivo microdialysis design was used to determine the D1- and D2-like receptor modulation of striatal ACh efflux in intact adult rats and those depleted of DA on postnatal Day 3. Systemic administration of the D1-like agonist SKF 38393 (1.0 or 10.0 mg/kg, or the D2-like antagonist clebopride (1.0 or 10.0 mg/kg) increased ACh efflux in both controls and DA-depleted animals. Systemic administration of the D1-like antagonist SCH 23390 (0.05 or 0.2 mg/kg) or D2-like agonist quinpirole (0.5 or 1.0 mg/kg) decreased ACh efflux in both groups of animals. DA-depleted animals exhibited a larger response than did controls to the lower doses of these drugs. Intrastriatal administration of clebopride (10 microM) increased ACh efflux in DA-depleted animals. Finally, basal and clebopride-stimulated ACh efflux were unaffected by the repeated microdialysis sessions. These data demonstrate that the reciprocal modulation of striatal ACh efflux, seen in controls and in rats depleted of DA as adults, is also present in adults depleted of DA as neonates. Because the roles of D1- and D2-receptors in the expression of motor behavior differ between rats depleted of DA as adults vs as neonates, these data suggest that alterations in the dopaminergic modulation of striatal ACh release do not underlie the sparing from motoric deficits seen in animals depleted of DA as neonates.

  3. Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres.

    PubMed

    Gejl, Kasper D; Ørtenblad, Niels; Andersson, Erik; Plomgaard, Peter; Holmberg, Hans-Christer; Nielsen, Joachim

    2017-05-01

    Glycogen is stored in local spatially distinct compartments within skeletal muscle fibres and is the main energy source during supramaximal exercise. Using quantitative electron microscopy, we show that supramaximal exercise induces a differential depletion of glycogen from these compartments and also demonstrate how this varies with fibre types. Repeated exercise alters this compartmentalized glycogen depletion. The results obtained in the present study help us understand the muscle metabolic dynamics of whole body repeated supramaximal exercise, and suggest that the muscle has a compartmentalized local adaptation to repeated exercise, which affects glycogen depletion. Skeletal muscle glycogen is heterogeneously distributed in three separated compartments (intramyofibrillar, intermyofibrillar and subsarcolemmal). Although only constituting 3-13% of the total glycogen volume, the availability of intramyofibrillar glycogen is of particular importance to muscle function. The present study aimed to investigate the depletion of these three subcellular glycogen compartments during repeated supramaximal exercise in elite athletes. Ten elite cross-country skiers (aged 25 ± 4 years, V̇O2 max : 65 ± 4 ml kg -1  min -1 ; mean ± SD) performed four ∼4 min supramaximal sprint time trials (STT 1-4) with 45 min of recovery. The subcellular glycogen volumes in musculus triceps brachii were quantified from electron microscopy images before and after both STT 1 and 4. During STT 1, the depletion of intramyofibrillar glycogen was higher in type 1 fibres [-52%; (-89:-15%)] than type 2 fibres [-15% (-52:22%)] (P = 0.02), whereas the depletion of intermyofibrillar glycogen [main effect: -19% (-33:0%), P = 0.006] and subsarcolemmal glycogen [main effect: -35% (-66:0%), P = 0.03] was similar between fibre types. By contrast, only intermyofibrillar glycogen volume was significantly reduced during STT 4, in both fibre types [main effect: -31% (-50:-11%), P = 0

  4. Repeated B cell depletion in treatment of refractory systemic lupus erythematosus

    PubMed Central

    Ng, K P; Leandro, M J; Edwards, J C; Ehrenstein, M R; Cambridge, G; Isenberg, D A

    2006-01-01

    Objectives To report the clinical outcome and safety profile of repeated B cell depletion in seven patients with refractory systemic lupus erythematosus (SLE). Methods Since June 2000, seven patients with refractory SLE had repeated cycles of B cell depletion (18 cycles in total, up to three cycles per patient) because of disease relapse. The clinical response (assessed by the British Isles Lupus Activity Guide (BILAG) activity index), duration of B cell depletion, and adverse events in these patients was reviewed. Results Four patients (Nos 1, 2, 3, 6) had three cycles of treatment and three (Nos 4, 5, 7) had two cycles. Four of the seven patients (Nos 1, 3, 5, 6) improved. The mean global BILAG scores dropped from 15 to 6 at 5–7 months. The median duration of clinical response and B cell depletion was 13 months and 6 months, respectively. After the third cycle, 2/4 patients (Nos 1 and 2) improved. The median duration of clinical benefit was 12 months. Most patients tolerate re‐treatment very well. Conclusion Re‐treatment with B cell depletion of patients with severe SLE is safe and may be effective for 6–12 months on average. PMID:16269424

  5. Depletion-Mode GaN HEMT Q-Spoil Switches for MRI Coils

    PubMed Central

    Lu, Jonathan Y.; Grafendorfer, Thomas; Zhang, Tao; Vasanawala, Shreyas; Robb, Fraser; Pauly, John M.; Scott, Greig C.

    2017-01-01

    Q-spoiling is the process of decoupling an MRI receive coil to protect the equipment and patient. Conventionally, Q-spoiling is performed using a PIN diode switch that draws significant current. In this work, a Q-spoiling technique using a depletion-mode Gallium Nitride HEMT device was developed for coil detuning at both 1.5 T and 3 T MRI. The circuits with conventional PIN diode Q-spoiling and the GaN HEMT device were implemented on surface coils. SNR was measured and compared for all surfaces coils. At both 1.5 T and 3 T, comparable SNR was achieved for all coils with the proposed technique and conventional Q-spoiling. The GaN HEMT device has significantly reduced the required power for Q-spoiling. The GaN HEMT device also provides useful safety features by detuning the coil when unpowered. PMID:27362895

  6. Resource depletion promotes automatic processing: implications for distribution of practice.

    PubMed

    Scheel, Matthew H

    2010-12-01

    Recent models of cognition include two processing systems: an automatic system that relies on associative learning, intuition, and heuristics, and a controlled system that relies on deliberate consideration. Automatic processing requires fewer resources and is more likely when resources are depleted. This study showed that prolonged practice on a resource-depleting mental arithmetic task promoted automatic processing on a subsequent problem-solving task, as evidenced by faster responding and more errors. Distribution of practice effects (0, 60, 120, or 180 sec. between problems) on rigidity also disappeared when groups had equal time on resource-depleting tasks. These results suggest that distribution of practice effects is reducible to resource availability. The discussion includes implications for interpreting discrepancies in the traditional distribution of practice effect.

  7. Improved radiation tolerance of MAPS using a depleted epitaxial layer

    NASA Astrophysics Data System (ADS)

    Dorokhov, A.; Bertolone, G.; Baudot, J.; Brogna, A. S.; Colledani, C.; Claus, G.; De Masi, R.; Deveaux, M.; Dozière, G.; Dulinski, W.; Fontaine, J.-C.; Goffe, M.; Himmi, A.; Hu-Guo, Ch.; Jaaskelainen, K.; Koziel, M.; Morel, F.; Santos, C.; Specht, M.; Valin, I.; Voutsinas, G.; Wagner, F. M.; Winter, M.

    2010-12-01

    Tracking performance of Monolithic Active Pixel Sensors (MAPS) developed at IPHC (Turchetta, et al., 2001) [1] have been extensively studied (Winter, et al., 2001; Gornushkin, et al., 2002) [2,3]. Numerous sensor prototypes, called MIMOSA, were fabricated and tested since 1999 in order to optimise the charge collection efficiency and power dissipation, to minimise the noise and to increase the readout speed. The radiation tolerance was also investigated. The highest fluence tolerable for a 10 μm pitch device was found to be ˜1013 neq/cm2, while it was only 2×1012 neq/cm2 for a 20 μm pitch device. The purpose of this paper is to show that the tolerance to non-ionising radiation may be extended up to O(10 14) n eq/cm 2. This goal relies on a fabrication process featuring a 15 μm thin, high resistivity ( ˜1 kΩ cm) epitaxial layer. A sensor prototype (MIMOSA-25) was fabricated in this process to explore its detection performance. The depletion depth of the epitaxial layer at standard CMOS voltages ( <5 V) is similar to the layer thickness. Measurements with m.i.p.s show that the charge collected in the seed pixel is at least twice larger for the depleted epitaxial layer than for the undepleted one, translating into a signal-to-noise ratio (SNR) of ˜50. Tests after irradiation have shown that this excellent performance is maintained up to the highest fluence considered ( 3×1013 neq/cm2), making evidence of a significant extension of the radiation tolerance limits of MAPS. Standing for minimum ionising particle.

  8. Stochastic interactions of two Brownian hard spheres in the presence of depletants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Karzar-Jeddi, Mehdi; Fan, Tai-Hsi, E-mail: thfan@engr.uconn.edu; Tuinier, Remco

    2014-06-07

    A quantitative analysis is presented for the stochastic interactions of a pair of Brownian hard spheres in non-adsorbing polymer solutions. The hard spheres are hypothetically trapped by optical tweezers and allowed for random motion near the trapped positions. The investigation focuses on the long-time correlated Brownian motion. The mobility tensor altered by the polymer depletion effect is computed by the boundary integral method, and the corresponding random displacement is determined by the fluctuation-dissipation theorem. From our computations it follows that the presence of depletion layers around the hard spheres has a significant effect on the hydrodynamic interactions and particle dynamicsmore » as compared to pure solvent and uniform polymer solution cases. The probability distribution functions of random walks of the two interacting hard spheres that are trapped clearly shift due to the polymer depletion effect. The results show that the reduction of the viscosity in the depletion layers around the spheres and the entropic force due to the overlapping of depletion zones have a significant influence on the correlated Brownian interactions.« less

  9. Soil Water Depletion After Four years of Forest Regrowth in SouthWestern Wisconsin

    Treesearch

    Richard S. Sartz; M. Dean Knighton

    1978-01-01

    The effect of cutting on water depletion from a 150-cm soil mantle does not appear to have diminished by the 7th year after the trees were cut. Mean seasonal depletion was 41, 64, and 146 mm for all vegetation removed, woody vegetation only removed, and uncut treatments, respectively. After 4 years of regrowth, the original bare and clearcut treatments depleted only...

  10. Bayesian analysis of multimethod ego-depletion studies favours the null hypothesis.

    PubMed

    Etherton, Joseph L; Osborne, Randall; Stephenson, Katelyn; Grace, Morgan; Jones, Chas; De Nadai, Alessandro S

    2018-04-01

    Ego-depletion refers to the purported decrease in performance on a task requiring self-control after engaging in a previous task involving self-control, with self-control proposed to be a limited resource. Despite many published studies consistent with this hypothesis, recurrent null findings within our laboratory and indications of publication bias have called into question the validity of the depletion effect. This project used three depletion protocols involved three different depleting initial tasks followed by three different self-control tasks as dependent measures (total n = 840). For each method, effect sizes were not significantly different from zero When data were aggregated across the three different methods and examined meta-analytically, the pooled effect size was not significantly different from zero (for all priors evaluated, Hedges' g = 0.10 with 95% credibility interval of [-0.05, 0.24]) and Bayes factors reflected strong support for the null hypothesis (Bayes factor > 25 for all priors evaluated). © 2018 The British Psychological Society.

  11. Methylphenidate blocks effort-induced depletion of regulatory control in healthy volunteers.

    PubMed

    Sripada, Chandra; Kessler, Daniel; Jonides, John

    2014-06-01

    A recent wave of studies--more than 100 conducted over the last decade--has shown that exerting effort at controlling impulses or behavioral tendencies leaves a person depleted and less able to engage in subsequent rounds of regulation. Regulatory depletion is thought to play an important role in everyday problems (e.g., excessive spending, overeating) as well as psychiatric conditions, but its neurophysiological basis is poorly understood. Using a placebo-controlled, double-blind design, we demonstrated that the psychostimulant methylphenidate (commonly known as Ritalin), a catecholamine reuptake blocker that increases dopamine and norepinephrine at the synaptic cleft, fully blocks effort-induced depletion of regulatory control. Spectral analysis of trial-by-trial reaction times revealed specificity of methylphenidate effects on regulatory depletion in the slow-4 frequency band. This band is associated with the operation of resting-state brain networks that produce mind wandering, which raises potential connections between our results and recent brain-network-based models of control over attention. © The Author(s) 2014.

  12. Sweetened blood sweetens behavior. Ego depletion, glucose, guilt, and prosocial behavior.

    PubMed

    Xu, Hanyi; Bègue, Laurent; Sauve, Laure; Bushman, Brad J

    2014-10-01

    Although guilt feels bad to the individual, it is good for society because guilty feelings can prompt people to perform good deeds. Previous research shows that fatigue decreases guilty feelings and helpful behavior. This present research tests whether glucose restores guilty feelings and increases helpful behavior. Depleted participants watched a movie about butchering animals for their meat or skin and were told to express no emotions, whereas non-depleted participants watched the same movie, but could express their emotions. Afterwards they drank a glucose or placebo beverage. Having participants play a game in which another person was punished for their errors induced guilt. Finally, participants played a dictator game in which they could leave lottery tickets for the next participant. Depleted participants felt less guilty and helped less than non-depleted participants, and those who consumed a placebo beverage felt less guilt and helped less than those who consumed a glucose beverage. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. The first demonstration of a microbial fuel cell as a viable power supply: Powering a meteorological buoy

    NASA Astrophysics Data System (ADS)

    Tender, Leonard M.; Gray, Sam A.; Groveman, Ethan; Lowy, Daniel A.; Kauffman, Peter; Melhado, Julio; Tyce, Robert C.; Flynn, Darren; Petrecca, Rose; Dobarro, Joe

    2008-05-01

    Here we describe the first demonstration of a microbial fuel cell (MFC) as a practical alternative to batteries for a low-power consuming application. The specific application reported is a meteorological buoy (ca. 18-mW average consumption) that measures air temperature, pressure, relative humidity, and water temperature, and that is configured for real-time line-of-sight RF telemetry of data. The specific type of MFC utilized in this demonstration is the benthic microbial fuel cell (BMFC). The BMFC operates on the bottom of marine environments, where it oxidizes organic matter residing in oxygen depleted sediment with oxygen in overlying water. It is maintenance free, does not deplete (i.e., will run indefinitely), and is sufficiently powerful to operate a wide range of low-power marine-deployed scientific instruments normally powered by batteries. Two prototype BMFCs used to power the buoy are described. The first was deployed in the Potomac River in Washington, DC, USA. It had a mass of 230 kg, a volume of 1.3 m3, and sustained 24 mW (energy equivalent of ca. 16 alkaline D-cells per year at 25 °C). Although not practical due to high cost and extensive in-water manipulation required to deploy, it established the precedence that a fully functional scientific instrument could derive all of its power from a BMFC. It also provided valuable lessons for developing a second, more practical BMFC that was subsequently used to power the buoy in a salt marsh near Tuckerton, NJ, USA. The second version BMFC has a mass of 16 kg, a volume of 0.03 m3, sustains ca. 36 mW (energy equivalent of ca. 26 alkaline D-cells per year at 25 °C), and can be deployed by a single person from a small craft with minimum or no in-water manipulation. This BMFC is being further developed to reduce cost and enable greater power output by electrically connecting multiple units in parallel. Use of this BMFC powering the meteorological buoy highlights the potential impact of BMFCs to enable long

  14. Dopamine Depletion Reduces Food-Related Reward Activity Independent of BMI

    PubMed Central

    Frank, Sabine; Veit, Ralf; Sauer, Helene; Enck, Paul; Friederich, Hans-Christoph; Unholzer, Theresa; Bauer, Ute-Maria; Linder, Katarzyna; Heni, Martin; Fritsche, Andreas; Preissl, Hubert

    2016-01-01

    Reward sensitivity and possible alterations in the dopaminergic-reward system are associated with obesity. We therefore aimed to investigate the influence of dopamine depletion on food-reward processing. We investigated 34 female subjects in a randomized placebo-controlled, within-subject design (body mass index (BMI)=27.0 kg/m2 ±4.79 SD; age=28 years ±4.97 SD) using an acute phenylalanine/tyrosine depletion drink representing dopamine depletion and a balanced amino acid drink as the control condition. Brain activity was measured with functional magnetic resonance imaging during a ‘wanting' and ‘liking' rating of food items. Eating behavior-related traits and states were assessed on the basis of questionnaires. Dopamine depletion resulted in reduced activation in the striatum and higher activation in the superior frontal gyrus independent of BMI. Brain activity during the wanting task activated a more distributed network than during the liking task. This network included gustatory, memory, visual, reward, and frontal regions. An interaction effect of dopamine depletion and the wanting/liking task was observed in the hippocampus. The interaction with the covariate BMI was significant in motor and control regions but not in the striatum. Our results support the notion of altered brain activity in the reward and prefrontal network with blunted dopaminergic action during food-reward processing. This effect is, however, independent of BMI, which contradicts the reward-deficiency hypothesis. This hints to the hypothesis suggesting a different or more complex mechanism underlying the dopaminergic reward function in obesity. PMID:26450814

  15. Ego depletion--is it all in your head? implicit theories about willpower affect self-regulation.

    PubMed

    Job, Veronika; Dweck, Carol S; Walton, Gregory M

    2010-11-01

    Much recent research suggests that willpower--the capacity to exert self-control--is a limited resource that is depleted after exertion. We propose that whether depletion takes place or not depends on a person's belief about whether willpower is a limited resource. Study 1 found that individual differences in lay theories about willpower moderate ego-depletion effects: People who viewed the capacity for self-control as not limited did not show diminished self-control after a depleting experience. Study 2 replicated the effect, manipulating lay theories about willpower. Study 3 addressed questions about the mechanism underlying the effect. Study 4, a longitudinal field study, found that theories about willpower predict change in eating behavior, procrastination, and self-regulated goal striving in depleting circumstances. Taken together, the findings suggest that reduced self-control after a depleting task or during demanding periods may reflect people's beliefs about the availability of willpower rather than true resource depletion.

  16. Analysis of total visual and ccd v-broadband observation of comet c/1995 o1 (hale-bopp): 1995-2003

    NASA Astrophysics Data System (ADS)

    de Almeida, A. A.; Boczko, R.; Lopes, A. R.; Sanzovo, G. C.

    The wealth of available information on total visual magnitudes and broadband-V CCD observations of the exceptionally bright Comet C/1995 O1 (Hale-Bopp) proved to be an excellent opportunity to test the Semi-Empirical Method of Visual Magnitudes (de Almeida, Singh & Huebner, 1997) for very bright comets. The main objective is to extend the method to include total visual magnitude observations obtained with CCD detector and V filter in our analysis of total visual magnitudes and obtain a single light curve. We compare the CCD V-broadband careful observations of Liller (1997) by plotting then together with the total visual magnitude observations from experienced visual observers found in the International Comet Quarterly (ICQ) archive. We find a nice agreement despite of the fact that CCDs and V filter passbands detect systematically more coma than visual observers, since they have different responses to C2, which is the main emission from the coma, and consequently they should be used with larger apperture diameters. A data set of ˜400 CCD selected observations covering about the same 5 years time span of the ˜12,000 ICQ total visual magnitude observations were used in the analysis. A least-squares fit to the values yielded a relation for water production rates vs heliocentric distances for the pre- and post-perihelion phases and are converted into gas production rates (in g/s) released by the nucleus. The dimension of the nucleus as well as its effective active area is determined and compared to other works.

  17. First tests of a novel radiation hard CMOS sensor process for Depleted Monolithic Active Pixel Sensors

    NASA Astrophysics Data System (ADS)

    Pernegger, H.; Bates, R.; Buttar, C.; Dalla, M.; van Hoorne, J. W.; Kugathasan, T.; Maneuski, D.; Musa, L.; Riedler, P.; Riegel, C.; Sbarra, C.; Schaefer, D.; Schioppa, E. J.; Snoeys, W.

    2017-06-01

    The upgrade of the ATLAS [1] tracking detector for the High-Luminosity Large Hadron Collider (LHC) at CERN requires novel radiation hard silicon sensor technologies. Significant effort has been put into the development of monolithic CMOS sensors but it has been a challenge to combine a low capacitance of the sensing node with full depletion of the sensitive layer. Low capacitance brings low analog power. Depletion of the sensitive layer causes the signal charge to be collected by drift sufficiently fast to separate hits from consecutive bunch crossings (25 ns at the LHC) and to avoid losing the charge by trapping. This paper focuses on the characterization of charge collection properties and detection efficiency of prototype sensors originally designed in the framework of the ALICE Inner Tracking System (ITS) upgrade [2]. The prototypes are fabricated both in the standard TowerJazz 180nm CMOS imager process [3] and in an innovative modification of this process developed in collaboration with the foundry, aimed to fully deplete the sensitive epitaxial layer and enhance the tolerance to non-ionizing energy loss. Sensors fabricated in standard and modified process variants were characterized using radioactive sources, focused X-ray beam and test beams before and after irradiation. Contrary to sensors manufactured in the standard process, sensors from the modified process remain fully functional even after a dose of 1015neq/cm2, which is the the expected NIEL radiation fluence for the outer pixel layers in the future ATLAS Inner Tracker (ITk) [4].

  18. Molecularly imprinted composite cryogels for hemoglobin depletion from human blood.

    PubMed

    Baydemir, Gözde; Andaç, Müge; Perçin, Işιk; Derazshamshir, Ali; Denizli, Adil

    2014-09-01

    A molecularly imprinted composite cryogel (MICC) was prepared for depletion of hemoglobin from human blood prior to use in proteome applications. Poly(hydroxyethyl methacrylate) based MICC was prepared with high gel fraction yields up to 90%, and characterized by Fourier transform infrared spectrophotometer, scanning electron microscopy, swelling studies, flow dynamics and surface area measurements. MICC exhibited a high binding capacity and selectivity for hemoglobin in the presence of immunoglobulin G, albumin and myoglobin. MICC column was successfully applied in fast protein liquid chromatography system for selective depletion of hemoglobin for human blood. The depletion ratio was highly increased by embedding microspheres into the cryogel (93.2%). Finally, MICC can be reused many times with no apparent decrease in hemoglobin adsorption capacity. Copyright © 2014 John Wiley & Sons, Ltd.

  19. High School and College Student Perceptions of the Ozone Depletion Problem.

    ERIC Educational Resources Information Center

    Groves, Fred; Pugh, Ava

    This paper examines the knowledge of high school biology students (n=107), undergraduate elementary education majors (n=42), and graduate students in an advanced elementary science methods course (n=22) about ozone depletion. The questionnaire used contained 30 items pertaining to ozone depletion which were divided into three subscales: (1)…

  20. Depletion of Vandium in Planetary Mantles: Controlled by Metal, Oxide, or Silicate?

    NASA Technical Reports Server (NTRS)

    Righter, Kevin

    2006-01-01

    Vanadium concentrations in planetary mantles can provide information about the conditions during early accretion and differentiation. Because V is a slightly siderophile element, it is usually assumed that any depletion would be due to core formation and metal-silicate equilibrium. However, V is typically more compatible in phases such as spinel, magnesiowuestite and garnet. Fractionation of all of these phases would cause depletions more marked than those from metal. In this paper consideration of depletions due to metal, oxide and silicate are critically evaluated.

  1. Novel treatment of severe combined immunodeficiency utilizing ex-vivo T-cell depleted haploidentical hematopoietic stem cell transplantation and CD45RA+ depleted donor lymphocyte infusions.

    PubMed

    Brodszki, Nicholas; Turkiewicz, Dominik; Toporski, Jacek; Truedsson, Lennart; Dykes, Josefina

    2016-01-15

    Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment available for severe combined immunodeficiency (SCID); although, there is a high incidence of severe infections and an increased risk of graft-versus host-disease (GvHD) with HSCT. Early intervention is a crucial prognostic factor and a HLA-haploidentical parental donor is often available. Haploidentical HSCT protocols utilizing extensively ex vivo T-cell depleted grafts (CliniMACs system) have proven efficient in preventing GvHD, but cause a delay in early T-cell recovery that increases the risk of viral infections. Here, we present a novel approach for treating SCID that combines selective depletion of GvHD-inducing alpha/beta (α/β) T-cells from the haploidentical HSCT graft with a subsequent donor lymphocyte infusion (DLI) enriched for CD45RO+ memory T-cells. Our patient was diagnosed with SCID (T-B + NK+ phenotype). At 9 months of age, he received a T cell receptor(TCR)α/β-cell depleted graft from his haploidentical mother, following a reduced intensity conditioning regimen with no additional GvHD prophylaxis. Engraftment was rapid with complete donor chimerism and no signs of GvHD. However, at 12 weeks post HSCT, the patient was still T-cell lymphopenic with clinical symptoms of multiple severe viral infections. Consequently, therapeutic DLIs were initiated for enhanced anti-viral immunity. The patient was treated with CD45RA+ depleted haploidentical maternal donor lymphocytes enriched from unmobilized whole blood, and a total T-cell dose of no more than 25 x10(3) CD3+ cells/kg with >99.9% purity of CD3 + CD45RO+ memory T-cells was transferred. Following the DLI, a prompt increase in CD3 + CD4+ and CD3 + CD8+ counts was observed with a subsequent clearance of viral infections. No acute or chronic GvHD was observed. Automated depletion of CD45RA+ naïve T-cells from unmobilized whole blood is a simple and rapid strategy to provide unmanipulated DLIs

  2. Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres

    PubMed Central

    Ørtenblad, Niels; Andersson, Erik; Plomgaard, Peter; Holmberg, Hans‐Christer; Nielsen, Joachim

    2016-01-01

    Key points Glycogen is stored in local spatially distinct compartments within skeletal muscle fibres and is the main energy source during supramaximal exercise.Using quantitative electron microscopy, we show that supramaximal exercise induces a differential depletion of glycogen from these compartments and also demonstrate how this varies with fibre types.Repeated exercise alters this compartmentalized glycogen depletion.The results obtained in the present study help us understand the muscle metabolic dynamics of whole body repeated supramaximal exercise, and suggest that the muscle has a compartmentalized local adaptation to repeated exercise, which affects glycogen depletion. Abstract Skeletal muscle glycogen is heterogeneously distributed in three separated compartments (intramyofibrillar, intermyofibrillar and subsarcolemmal). Although only constituting 3–13% of the total glycogen volume, the availability of intramyofibrillar glycogen is of particular importance to muscle function. The present study aimed to investigate the depletion of these three subcellular glycogen compartments during repeated supramaximal exercise in elite athletes. Ten elite cross‐country skiers (aged 25 ± 4 years, V˙O2 max : 65 ± 4 ml kg−1 min−1; mean ± SD) performed four ∼4 min supramaximal sprint time trials (STT 1–4) with 45 min of recovery. The subcellular glycogen volumes in musculus triceps brachii were quantified from electron microscopy images before and after both STT 1 and 4. During STT 1, the depletion of intramyofibrillar glycogen was higher in type 1 fibres [−52%; (−89:−15%)] than type 2 fibres [−15% (−52:22%)] (P = 0.02), whereas the depletion of intermyofibrillar glycogen [main effect: −19% (−33:0%), P = 0.006] and subsarcolemmal glycogen [main effect: −35% (−66:0%), P = 0.03] was similar between fibre types. By contrast, only intermyofibrillar glycogen volume was significantly reduced during STT 4, in both fibre types

  3. Design of a high altitude long endurance flying-wing solar-powered unmanned air vehicle

    NASA Astrophysics Data System (ADS)

    Alsahlani, A. A.; Johnston, L. J.; Atcliffe, P. A.

    2017-06-01

    The low-Reynolds number environment of high-altitude §ight places severe demands on the aerodynamic design and stability and control of a high altitude, long endurance (HALE) unmanned air vehicle (UAV). The aerodynamic efficiency of a §ying-wing configuration makes it an attractive design option for such an application and is investigated in the present work. The proposed configuration has a high-aspect ratio, swept-wing planform, the wing sweep being necessary to provide an adequate moment arm for outboard longitudinal and lateral control surfaces. A design optimization framework is developed under a MATLAB environment, combining aerodynamic, structural, and stability analysis. Low-order analysis tools are employed to facilitate efficient computations, which is important when there are multiple optimization loops for the various engineering analyses. In particular, a vortex-lattice method is used to compute the wing planform aerodynamics, coupled to a twodimensional (2D) panel method to derive aerofoil sectional characteristics. Integral boundary-layer methods are coupled to the panel method in order to predict §ow separation boundaries during the design iterations. A quasi-analytical method is adapted for application to flyingwing con¦gurations to predict the wing weight and a linear finite-beam element approach is used for structural analysis of the wing-box. Stability is a particular concern in the low-density environment of high-altitude flight for flying-wing aircraft and so provision of adequate directional stability and control power forms part of the optimization process. At present, a modified Genetic Algorithm is used in all of the optimization loops. Each of the low-order engineering analysis tools is validated using higher-order methods to provide con¦dence in the use of these computationally-efficient tools in the present design-optimization framework. This paper includes the results of employing the present optimization tools in the design of a

  4. CO in Distantly Active Comets

    NASA Astrophysics Data System (ADS)

    Womack, M.; Sarid, G.; Wierzchos, K.

    2017-03-01

    The activity of most comets near the Sun is dominated by the sublimation of frozen water, the most abundant ice in comets. Some comets, however, are active well beyond the water-ice sublimation limit of ˜3 au. Three bodies dominate the observational record and modeling efforts for distantly active comets: the long-period comet C/1995 O1 (Hale-Bopp), and the short-period comets (with Centaur orbits) 29P/Schwassmann-Wachmann 1 and 2060 Chiron. We summarize what is known about these three objects with an emphasis on their gaseous comae. We calculate their CN/CO and CO2/CO production rate ratios from the literature and discuss implications, such as HCN and CO2 outgassing are not significant contributors to their comae. Using our own data we derive CO production rates, Q(CO), for all three objects to examine whether there is a correlation between gas production and different orbital histories and/or size. The CO measurements of Hale-Bopp (4-11 AU) and 29P are consistent with a nominal production rate of Q(CO) = 3.5 × 1029 r-2 superimposed with sporadic outbursts. The similarity of Hale-Bopp CO production rates for pre- and post-perihelion suggests that thermal inertia was not very important and therefore most of the activity is at or near the surface of the comet. We further examine the applicability of existing models in explaining the systematic behavior of our small sample. We find that orbital history does not appear to play a significant role in explaining 29P’s CO production rates. 29P outproduces Hale-Bopp at the same heliocentric distance, even though it has been subjected to much more solar heating. Previous modeling work on such objects predicts that 29P should have been devolatilized over a fresher comet like Hale-Bopp. This may point to 29P having a different orbital history than current models predict, with its current orbit acquired more recently. On the other hand, Chiron’s CO measurements are consistent with it being significantly depleted over its

  5. In vivo T cell depletion regulates resistance and morbidity in murine schistosomiasis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Phillips, S.M.; Linette, G.P.; Doughty, B.L.

    1987-08-01

    These studies assessed the roles of subpopulations of T lymphocytes in inducing and modulating resistance to schistosomiasis and thereby influencing subsequent morbidity. C57BL/6 mice were depleted in vivo of Lyt-1+, Lyt-2+, and L3T4+ cells by the daily administration of monoclonal antibodies. The development of protective immunity, induced by exposure to irradiated Schistosoma mansoni cercariae as expressed in depleted animals, was compared to that demonstrated in undepleted, normal, and congenitally athymic C57BL/6 mice. The development of morbidity was determined by spleen weight, portal pressure and reticuloendothelial system activity. The results indicated that depletion of specific subpopulations of T lymphocytes minimally affectedmore » the primary development of parasites; however, depletion strongly influenced the development of resistance to the parasite and subsequent morbidity due to infection. Depletion of T lymphocytes by anti-Lyt-1+ or anti-L3T4+ antibody decreased the development of resistance, antibody and delayed-type hypersensitivity directed against schistosome antigens. Morbidity due to disease was increased. Depletion of Lyt-2+ cells produced opposite changes with augmented resistance and reduced morbidity. Congenitally athymic mice developed minimal resistance and morbidity. Moreover, resistance was inversely related to the morbidity shown by a given animal. These studies indicate that the development of protective immunity to S. mansoni cercariae is regulated by discrete subpopulations of T lymphocytes. The feasibility of decreasing morbidity by increasing specific immunologically mediated resistance is suggested.« less

  6. A method to estimate groundwater depletion from confining layers

    USGS Publications Warehouse

    Konikow, Leonard F.; Neuzil, Christopher E.

    2007-01-01

    Although depletion of storage in low‐permeability confining layers is the source of much of the groundwater produced from many confined aquifer systems, it is all too frequently overlooked or ignored. This makes effective management of groundwater resources difficult by masking how much water has been derived from storage and, in some cases, the total amount of water that has been extracted from an aquifer system. Analyzing confining layer storage is viewed as troublesome because of the additional computational burden and because the hydraulic properties of confining layers are poorly known. In this paper we propose a simplified method for computing estimates of confining layer depletion, as well as procedures for approximating confining layer hydraulic conductivity (K) and specific storage (Ss) using geologic information. The latter makes the technique useful in developing countries and other settings where minimal data are available or when scoping calculations are needed. As such, our approach may be helpful for estimating the global transfer of groundwater to surface water. A test of the method on a synthetic system suggests that the computational errors will generally be small. Larger errors will probably result from inaccuracy in confining layer property estimates, but these may be no greater than errors in more sophisticated analyses. The technique is demonstrated by application to two aquifer systems: the Dakota artesian aquifer system in South Dakota and the coastal plain aquifer system in Virginia. In both cases, depletion from confining layers was substantially larger than depletion from the aquifers.

  7. IL-7 receptor blockade following T cell depletion promotes long-term allograft survival

    PubMed Central

    Mai, Hoa-Le; Boeffard, Françoise; Longis, Julie; Danger, Richard; Martinet, Bernard; Haspot, Fabienne; Vanhove, Bernard; Brouard, Sophie; Soulillou, Jean-Paul

    2014-01-01

    T cell depletion is commonly used in organ transplantation for immunosuppression; however, a restoration of T cell homeostasis following depletion leads to increased memory T cells, which may promote transplant rejection. The cytokine IL-7 is important for controlling lymphopoiesis under both normal and lymphopenic conditions. Here, we investigated whether blocking IL-7 signaling with a mAb that targets IL-7 receptor α (IL-7Rα) alone or following T cell depletion confers an advantage for allograft survival in murine transplant models. We found that IL-7R blockade alone induced indefinite pancreatic islet allograft survival if anti–IL-7R treatment was started 3 weeks before graft. IL-7R blockade following anti-CD4– and anti-CD8–mediated T cell depletion markedly prolonged skin allograft survival. Furthermore, IL-7 inhibition in combination with T cell depletion synergized with either CTLA-4Ig administration or suboptimal doses of tacrolimus to induce long-term skin graft acceptance in this stringent transplant model. Together, these therapies inhibited T cell reconstitution, decreased memory T cell numbers, increased the relative frequency of Tregs, and abrogated both cellular and humoral alloimmune responses. Our data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppressive therapy in transplantation. PMID:24569454

  8. The Effect of Implicit Preferences on Food Consumption: Moderating Role of Ego Depletion and Impulsivity

    PubMed Central

    Wang, Yan; Zhu, Jinglei; Hu, Yi; Fang, Yuan; Wang, Guosen; Cui, Xianghua; Wang, Lei

    2016-01-01

    Ego depletion has been found to moderate the effect of implicit preferences on food consumption, such that implicit preferences predict consumption only under a depleted state. The present study tested how trait impulsivity impacts the effect of implicit preferences on food consumption in a depleted condition. Trait impulsivity was measured by means of self-report and a stop signal task. Results showed that both self-reported impulsivity and behavioral impulsivity moderated the ‘depletion and then eating according to implicit preferences’ effect, albeit in different ways. Participants high in self-reported impulsivity and low in behavioral impulsivity were more vulnerable to the effect of depletion on eating. The implications of these results for extant theories are discussed. Future research is needed to verify whether or not trait impulsivity is associated with vulnerability to depletion across different self-control domains. PMID:27881966

  9. Creatine pretreatment protects cortical axons from energy depletion in vitro

    PubMed Central

    Shen, Hua; Goldberg, Mark P.

    2012-01-01

    Creatine is a natural nitrogenous guanidino compound involved in bioenergy metabolism. Although creatine has been shown to protect neurons of the central nervous system (CNS) from experimental hypoxia/ischemia, it remains unclear if creatine may also protect CNS axons, and if the potential axonal protection depends on glial cells. To evaluate the direct impact of creatine on CNS axons, cortical axons were cultured in a separate compartment from their somas and proximal neurites using a modified two-compartment culture device. Axons in the axon compartment were subjected to acute energy depletion, an in vitro model of white matter ischemia, by exposure to 6 mM sodium azide for 30 min in the absence of glucose and pyruvate. Energy depletion reduced axonal ATP by 65%, depolarized axonal resting potential, and damaged 75% of axons. Application of creatine (10 mM) to both compartments of the culture at 24 h prior to energy depletion significantly reduced axonal damage by 50%. In line with the role of creatine in the bioenergy metabolism, this application also alleviated the axonal ATP loss and depolarization. Inhibition of axonal depolarization by blocking sodium influx with tetrodotoxin also effectively reduced the axonal damage caused by energy depletion. Further study revealed that the creatine effect was independent of glial cells, as axonal protection was sustained even when creatine was applied only to the axon compartment (free from somas and glial cells) for as little as 2 h. In contrast, application of creatine after energy depletion did not protect axons. The data provide the first evidence that creatine pretreatment may directly protect CNS axons from energy deficiency. PMID:22521466

  10. Aqueous Colloid + Polymer Depletion System for Confocal Microscopy and Rheology

    NASA Astrophysics Data System (ADS)

    Park, Nayoung; Umanzor, Esmeralda J.; Conrad, Jacinta C.

    2018-05-01

    We developed a model depletion system with colloidal particles that were refractive index- and density-matched to 80 (w/w)% glycerol in water, and characterized the effect of interparticle interactions on the structure and dynamics of non-equilibrium phases. 2,2,2-trifluoroethyl methacrylate-co-tert-butyl methacrylate copolymer particles were synthesized following Kodger et al. (Sci. Rep. 5, 14635 (2015)). Particles were dispersed in glycerol/water solutions to generate colloidal suspensions with good control over electrostatic interactions and a moderately high background viscosity of 55 mPa-s. To probe the effects of charge screening and depletion attractions on the suspension phase behavior, we added NaCl and polyacrylamide (M_w = 186 kDa) at various concentrations to particle suspensions formulated at volume fractions of phi = 0.05 and 0.3 and imaged the suspensions using confocal microscopy. The particles were nearly hard spheres at a NaCl concentration of 20 mM, but aggregated when the concentration of NaCl was further increased. Changes in the particle structure and dynamics with increasing concentration of the depletant polyacrylamide followed the trends expected from earlier experiments on depletion-driven gelation. Additionally, we measured the viscosity and corrected first normal stress difference of suspensions formulated at phi = 0.4 with and without added polymer. The solvent viscosity was suitable for rheology measurements without the onset of instabilities such as secondary flows or edge fracture. These results validate this system as an alternative to one common model system, suspensions of poly(methyl methacrylate) particles and polystyrene depletants in organic solvents, for investigating phase behavior and flow properties in attractive colloidal suspensions.

  11. The Influence of Agreeableness and Ego Depletion on Emotional Responding.

    PubMed

    Finley, Anna J; Crowell, Adrienne L; Harmon-Jones, Eddie; Schmeichel, Brandon J

    2017-10-01

    Agreeable individuals report more intense withdrawal-oriented negative emotions across aversive situations. Two studies tested the hypothesis that self-regulatory depletion (i.e., ego depletion) moderates the relationship between trait Agreeableness and negative emotional responding. Ego depletion was manipulated using a writing task. Emotional responding was measured with startle eye-blink responses (Study 1, N = 71) and self-reported valence, arousal, and empathic concern (Study 2, N = 256) during emotional picture viewing. Trait Agreeableness was measured using a questionnaire. In Study 1, Agreeableness predicted especially large startle responses during aversive images and especially small startles during appetitive images. After exercising self-control, the relationship between startle magnitudes and Agreeableness decreased. In Study 2, Agreeableness predicted more empathic concern for aversive images, which in turn predicted heightened self-reported negative emotions. After exercising self-control, the relationship between Agreeableness and empathic concern decreased. Agreeable individuals exhibit heightened negative emotional responding. Ego depletion reduced the link between Agreeableness and negative emotional responding in Study 1 and moderated the indirect effect of Agreeableness on negative emotional responding via empathic concern in Study 2. Empathic concern appears to be a resource-intensive process underlying heightened responding to aversive stimuli among agreeable persons. © 2016 Wiley Periodicals, Inc.

  12. Depleted uranium as a backfill for nuclear fuel waste package

    DOEpatents

    Forsberg, Charles W.

    1998-01-01

    A method for packaging spent nuclear fuel for long-term disposal in a geological repository. At least one spent nuclear fuel assembly is first placed in an unsealed waste package and a depleted uranium fill material is added to the waste package. The depleted uranium fill material comprises flowable particles having a size sufficient to substantially fill any voids in and around the assembly and contains isotopically-depleted uranium in the +4 valence state in an amount sufficient to inhibit dissolution of the spent nuclear fuel from the assembly into a surrounding medium and to lessen the potential for nuclear criticality inside the repository in the event of failure of the waste package. Last, the waste package is sealed, thereby substantially reducing the release of radionuclides into the surrounding medium, while simultaneously providing radiation shielding and increased structural integrity of the waste package.

  13. Analysis of the depletion of a stored aerosol in low gravity

    NASA Technical Reports Server (NTRS)

    Squires, P.

    1977-01-01

    The depletion of an aerosol stored in a container has been studied in l-g and in low gravity. Models were developed for sedimentation, coagulation and diffusional losses to the walls. The overall depletion caused by these three mechanisms is predicted to be of order 5 to 8 percent per hour in terrestrial conditions, which agrees with laboratory experience. Applying the models to a low gravity situation indicates that there only coagulation will be significant. (Gravity influences diffusional losses because of convection currents caused by random temperature gradients). For the types of aerosol studied, the rate of depletion of particles should be somewhat less than 0.001 N percent per hour, where N is the concentration per cu cm.

  14. Depletion zones and crystallography on pinched spheres

    NASA Astrophysics Data System (ADS)

    Chen, Jingyuan; Xing, Xiangjun; Yao, Zhenwei

    2018-03-01

    Understanding the interplay between ordered structures and substrate curvature is an interesting problem with versatile applications, including functionalization of charged supramolecular surfaces and modern microfluidic technologies. In this work, we investigate the two-dimensional packing structures of charged particles confined on a pinched sphere. By continuously pinching the sphere, we observe cleavage of elongated scars into pleats, proliferation of disclinations, and subsequently, emergence of a depletion zone at the negatively curved waist that is completely void of particles. We systematically study the geometrics and energetics of the depletion zone, and reveal its physical origin as a finite size effect, due to the interplay between Coulomb repulsion and concave geometry of the pinched sphere. These results further our understanding of crystallography on curved surfaces, and have implications in design and manipulation of charged, deformable interfaces in various applications.

  15. Lower hybrid wave phenomena associated with density depletions

    NASA Technical Reports Server (NTRS)

    Seyler, C. E.

    1994-01-01

    A fluid description of lower hybrid, whistler and magnetosonic waves is applied to study wave phenomena near the lower hybrid resonance associated with plasma density depletions. The goal is to understand the nature of lower hybrid cavitons and spikelets often associated with transverse ion acceleration events in the auroral ionosphere. Three-dimensional simulations show the ponderomotive force leads to the formation of a density cavity (caviton) in which lower hybrid wave energy is concentrated (spikelet) resulting in a three-dimensional collapse of the configuration. Plasma density depletions of the order of a few percent are shown to greatly modify the homogeneous linear properties of lower hybrid waves and account for many of the observed features of lower hybrid spikelets.

  16. The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.

    PubMed Central

    Russo, A.; Mitchell, J. B.; McPherson, S.

    1984-01-01

    The effects of cellular glutathione depletion by buthionine sulfoximine on the development of thermotolerance and synthesis of heat stress protein was studied. Cellular glutathione levels were found to increase rapidly following an acute heat treatment of either 12 min at 45.5 degrees C or 1 h at 43 degrees C and remain elevated for prolonged periods. Glutathione depletion and prevention of glutathione synthesis by buthionine sulfoximine resulted in inhibition of the development of thermotolerance and a decrease in total protein as well as specific heat stress proteins. While the degree of inhibition of thermotolerance was similar for both glutathione depletion protocols, inhibition in heat stress protein synthesis was greater when glutathione was depleted to low levels prior to heating. The possible role of glutathione and the cellular redox state to thermotolerance and synthesis of heat stress protein is discussed. Images Figure 2 PMID:6733022

  17. CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: Depletion interactions in a cylindric pipeline

    NASA Astrophysics Data System (ADS)

    Huang, Li-Xin; Gao, Hai-Xia; Li, Chun-Shu; Xiao, Chang-Ming

    2009-08-01

    In a colloidal system confined by a small cylindric pipeline, the depletion interaction between two large spheres is different to the system confined by two plates, and the influence on depletion interaction from the pipeline is related to both the size and shape of it. In this paper, the depletion interactions in the systems confined by pipelines of different sizes or different shapes are studied by Monte Carlo simulations. The numerical results show that the influence on depletion force from the cylindric pipeline is stronger than that from two parallel plates, and the depletion force will be strengthened when the diameter of the cylinder is decreased. In addition, we also find that the depletion interaction is rather affected if the shape change of the pipeline is slightly changed, and the influence on depletion force from the shape change is stronger than that from the size change.

  18. A modern depleted uranium manufacturing facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zagula, T.A.

    1995-07-01

    The Specific Manufacturing Capabilities (SMC) Project located at the Idaho National Engineering Laboratory (INEL) and operated by Lockheed Martin Idaho Technologies Co. (LMIT) for the Department of Energy (DOE) manufactures depleted uranium for use in the U.S. Army MIA2 Abrams Heavy Tank Armor Program. Since 1986, SMC has fabricated more than 12 million pounds of depleted uranium (DU) products in a multitude of shapes and sizes with varying metallurgical properties while maintaining security, environmental, health and safety requirements. During initial facility design in the early 1980`s, emphasis on employee safety, radiation control and environmental consciousness was gaining momentum throughout themore » DOE complex. This fact coupled with security and production requirements forced design efforts to focus on incorporating automation, local containment and computerized material accountability at all work stations. The result was a fully automated production facility engineered to manufacture DU armor packages with virtually no human contact while maintaining security, traceability and quality requirements. This hands off approach to handling depleted uranium resulted in minimal radiation exposures and employee injuries. Construction of the manufacturing facility was complete in early 1986 with the first armor package certified in October 1986. Rolling facility construction was completed in 1987 with the first certified plate produced in the fall of 1988. Since 1988 the rolling and manufacturing facilities have delivered more than 2600 armor packages on schedule with 100% final product quality acceptance. During this period there was an annual average of only 2.2 lost time incidents and a single individual maximum radiation exposure of 150 mrem. SMC is an example of designing and operating a facility that meets regulatory requirements with respect to national security, radiation control and personnel safety while achieving production schedules and product

  19. Neutrophil Depletion during Toxoplasma gondii Infection Leads to Impaired Immunity and Lethal Systemic Pathology

    PubMed Central

    Bliss, Susan K.; Gavrilescu, L. Cristina; Alcaraz, Ana; Denkers, Eric Y.

    2001-01-01

    The immunomodulatory role of neutrophils during infection with Toxoplasma gondii was investigated. Monoclonal antibody-mediated depletion revealed that neutrophils are essential for survival during the first few days of infection. Moreover, neutrophil depletion was associated with a weaker type 1 immune response as measured by decreased levels of gamma interferon, interleukin-12 (IL-12) and tumor necrosis factor alpha. IL-10 was also decreased in depleted animals. Additionally, splenic populations of CD4+ T cells, CD8+ T cells, and NK1.1+ cells were decreased in depleted mice. Neutrophil-depleted mice exhibited lesions of greater severity in tissues examined and a greater parasite burden as determined by histopathology and reverse transcription-PCR. We conclude that neutrophils are critical near the time of infection because they influence the character of the immune response and control tachyzoite replication. PMID:11447166

  20. Depletion of CpG Dinucleotides in Papillomaviruses and Polyomaviruses: A Role for Divergent Evolutionary Pressures.

    PubMed

    Upadhyay, Mohita; Vivekanandan, Perumal

    2015-01-01

    Papillomaviruses and polyomaviruses are small ds-DNA viruses infecting a wide-range of vertebrate hosts. Evidence supporting co-evolution of the virus with the host does not fully explain the evolutionary path of papillomaviruses and polyomaviruses. Studies analyzing CpG dinucleotide frequencies in virus genomes have provided interesting insights on virus evolution. CpG dinucleotide depletion has not been extensively studied among papillomaviruses and polyomaviruses. We sought to analyze the relative abundance of dinucleotides and the relative roles of evolutionary pressures in papillomaviruses and polyomaviruses. We studied 127 full-length sequences from papillomaviruses and 56 full-length sequences from polyomaviruses. We analyzed the relative abundance of dinucleotides, effective codon number (ENC), differences in synonymous codon usage. We examined the association, if any, between the extent of CpG dinucleotide depletion and the evolutionary lineage of the infected host. We also investigated the contribution of mutational pressure and translational selection to the evolution of papillomaviruses and polyomaviruses. All papillomaviruses and polyomaviruses are CpG depleted. Interestingly, the evolutionary lineage of the infected host determines the extent of CpG depletion among papillomaviruses and polyomaviruses. CpG dinucleotide depletion was more pronounced among papillomaviruses and polyomaviruses infecting human and other mammals as compared to those infecting birds. Our findings demonstrate that CpG depletion among papillomaviruses is linked to mutational pressure; while CpG depletion among polyomaviruses is linked to translational selection. We also present evidence that suggests methylation of CpG dinucleotides may explain, at least in part, the depletion of CpG dinucleotides among papillomaviruses but not polyomaviruses. The extent of CpG depletion among papillomaviruses and polyomaviruses is linked to the evolutionary lineage of the infected host. Our

  1. Global Warming: Lessons from Ozone Depletion

    ERIC Educational Resources Information Center

    Hobson, Art

    2010-01-01

    My teaching and textbook have always covered many physics-related social issues, including stratospheric ozone depletion and global warming. The ozone saga is an inspiring good-news story that's instructive for solving the similar but bigger problem of global warming. Thus, as soon as students in my physics literacy course at the University of…

  2. Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice.

    PubMed

    Ou, Rongying; Liu, Jia; Lv, Mingfen; Wang, Jingying; Wang, Jinmeng; Zhu, Li; Zhao, Liang; Xu, Yunsheng

    2017-07-01

    Non-alcoholic fatty liver disease is highly associated with morbidity and mortality in population. Although studies have already demonstrated that the immune response plays a pivotal role in the development of non-alcoholic fatty liver disease, the comprehensive regulation is unclear. Therefore, present study was carried out to investigate the non-alcoholic fatty liver disease development under neutrophil depletion. To achieve the aim of the study, C57BL/6 J mice were fed with high fat diet for 6 weeks before treated with neutrophil deplete antibody 1A8 or isotype control (200 μg/ mouse every week) for another 4 weeks. Treated with 1A8 antibody, obese mice exhibited better whole body metabolic parameters, including reduction of body weight gain and fasting blood glucose levels. Neutrophil depletion also effectively reduced hepatic structural disorders, dysfunction and lipid accumulation. Lipid β-oxidative markers, phosphorylated-AMP-activated protein kinase α and phosphorylated-acetyl-CoA carboxylase levels were increased in 1A8 antibody-treated obese mouse group. The mitochondrial number and function were also reversed after 1A8 antibody treatment, including increased mitochondrial number, reduced lipid oxidative damage and enhanced mitochondrial activity. Furthermore, the expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-6, and monocyte chemoattractant protein-1 were obviously reduced after neutrophil depletion, accompanied with decreased F4/80 mRNA level and macrophage percentage in liver. The decreased NF-κB signaling activity was also involved in the beneficial effect of neutrophil depletion. Taken together, neutrophil depletion could attenuate metabolic syndromes and hepatic dysfunction.

  3. Ozone depletion, related UVB changes and increased skin cancer incidence

    NASA Astrophysics Data System (ADS)

    Kane, R. P.

    1998-03-01

    Stratospheric ozone at middle latitudes shows a seasonal variation of about +/-20%, a quasi-biennial oscillation of 1-10% range and a long-term variation in which the level was almost steady up to about 1979 and declined thereafter to the present day by about 10%. These variations are expected to be reflected in solar UVB observed at the ground, but in an opposite direction. Thus UVB should have had a long-term increase of about 10-20%, which should cause an increase in skin cancer incidence of about 20-40%. Skin cancer incidence has increased all over the world, e.g. about 90% in USA during 1974-1990. It is popularly believed that this increase in skin cancer incidence is related to the recent ozone depletion. This seems to be incorrect, for two reasons. Firstly, the observed skin cancer increase is too large (90%) compared with the expected value (40%) from ozone depletion. Secondly, cancer does not develop immediately after exposure to solar UVB. The sunburns may occur within hours; but cancer development and detection may take years, even decades. Hence the observed skin cancer increase since 1974 (no data available for earlier periods) must have occurred due to exposure to solar UVB in the 1950s and 1960s, when there was no ozone depletion. Thus, the skin cancer increase must be attributed to harmful solar UVB levels existing even in the 1960s, accentuated later not by ozone depletion (which started only much later, by 1979) but by other causes, such as a longer human life span, better screening, increasing tendencies of sunbathing at beaches, etc., in affluent societies. On the other hand, the recent ozone depletion and the associated UVB increases will certainly take their toll; only that the effects will not be noticed now but years or decades from now. The concern for the future expressed in the Montreal Protocol for reducing ozone depletion by controlling CFC production is certainly justified, especially because increased UVB is harmful to animal and

  4. Depletion of highly abundant proteins in blood plasma by ammonium sulfate precipitation for 2D-PAGE analysis.

    PubMed

    Mahn, Andrea; Ismail, Maritza

    2011-11-15

    Ammonium sulfate precipitation (ASP) was explored as a method for depleting some highly abundant proteins from blood plasma, in order to reduce the dynamic range of protein concentration and to improve the detection of low abundance proteins by 2D-PAGE. 40% ammonium sulfate saturation was chosen since it allowed depleting 39% albumin and 82% α-1-antitrypsin. ASP-depletion showed high reproducibility in 2D-PAGE analysis (4.2% variation in relative abundance of albumin), similar to that offered by commercial affinity-depletion columns. Besides, it allowed detecting 59 spots per gel, very close to the number of spots detected in immuno-affinity-depleted plasma. Thus, ASP at 40% saturation is a reliable depletion method that may help in proteomic analysis of blood plasma. Finally, ASP-depletion seems to be complementary to hydrophobic interaction chromatography (HIC)-depletion, and therefore an ASP-step followed by a HIC-step could probably deplete the most highly abundant plasma proteins, thus improving the detection of low abundance proteins by 2D-PAGE. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. STS-121: Discovery Entry Flight Director Post Landing Press Conference

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Steve Stitch, STS-121 Entry Flight Director, and Wayne Hale, Space Shuttle Program is shown in this post landing press conference. Steve Stitch begins with discussing the following topics: 1) Weather at Kennedy Space Center; 2) Gap filler protrusion; 3) De-orbit burn; 4) Space Shuttle Landing; 5) Global Position Satellite System (GPSS) performance; and 6) Post-landing rain showers. Wayne Hale discusses external tank observations at launch and the goals that were obtained by this flight, which are to deliver 4000 pounds of scientific equipment, increase the crew members to three on the International Space Station (ISS), and repair the ISS. Questions from the press on lessons learned from the Auxiliary Power Unit (APU) leak, and flight readiness reviews are addressed.

  6. Potential For Stratospheric Ozone Depletion During Carboniferous

    NASA Astrophysics Data System (ADS)

    Bill, M.; Goldstein, A. H.

    Methyl bromide (CH3Br) constitutes the largest source of bromine atoms to the strato- sphere whereas methyl chloride (CH3Cl) is the most abundant halocarbon in the tro- posphere. Both gases play an important role in stratospheric ozone depletion. For in- stance, Br coupled reactions are responsible for 30 to 50 % of total ozone loss in the polar vortex. Currently, the largest natural sources of CH3Br and CH3Cl appear to be biological production in the oceans, inorganic production during biomass burning and plant production in salt marsh ecosystems. Variations of paleofluxes of CH3Br and CH3Cl can be estimated by analyses of oceanic paleoproductivity, stratigraphic analyses of frequency and distribution of fossil charcoal indicating the occurrence of wildfires, and/or by paleoreconstruction indicating the extent of salt marshes. Dur- ing the lower Carboniferous time (Tournaisian-Visean), the southern margin of the Laurasian continent was characterized by charcoal deposits. Estimation on frequency of charcoal layers indicates that wildfires occur in a range of 3-35 years (Falcon-Lang 2000). This suggests that biomass burning could be an important source of CH3Br and CH3Cl during Tournaisian-Viesan time. During Tounaisian and until Merame- cian carbon and oxygen isotope records have short term oscillations (Bruckschen et al. 1999, Mii et al. 1999). Chesterian time (mid- Carboniferous) is marked by an in- crease in delta18O values ( ~ 2 permil) and an increase of glacial deposit frequency suggesting lower temperatures. The occurrence of glacial deposits over the paleopole suggests polar conditions and the associated special features of polar mete- orology such as strong circumpolar wind in the stratosphere (polar vortex) and polar stratospheric clouds. Thus, conditions leading to polar statospheric ozone depletion can be found. Simultaneously an increase in delta13C values is documented. We interpret the positive shift in delta13C as a result of higher bioproductivity

  7. Executive function depletion in children and its impact on theory of mind.

    PubMed

    Powell, Lindsey J; Carey, Susan

    2017-07-01

    The current studies provide an experimental, rather than correlational, method for testing hypotheses about the role of executive function (EF) in conceptual development. Previous research has established that adults' tendency to deploy EF can be temporarily diminished by use. Exercising self-control in one context decreases adults' performance on other EF demanding tasks immediately thereafter. Using two different depletion methods, Experiments 1 and 3 extend this finding to preschool-aged children. Experiments 2 and 4 make use of these EF depletion methods to elucidate the role of EF in children's theory of mind reasoning. Experiment 2 shows that EF depletion affects 5-year-olds' ability to predict another's behavior on the basis of that person's false belief, and Experiment 4 shows that this negative effect of depletion extends to 4- and 5-year-olds' ability to explain others' behavior on the basis of their false beliefs. These findings provide direct evidence that EF is required for the expression of an understanding of others' false beliefs across a variety of task demands, even in children who clearly have the capacity to construct such representations. We suggest ways in which depletion may be used as a tool for further investigating the role of executive function in cognitive development. Copyright © 2017. Published by Elsevier B.V.

  8. Photosensitivity in the circadian hatching rhythm of the carotenoid-depleted silkworm, Bombyx mori.

    PubMed

    Sakamoto, K; Shimizu, I

    1994-01-01

    Silkworms (Bombyx mori) were reared on a carotenoid-deprived artificial diet, and the carotenoid-depleted eggs of the next generation were incubated so that we could observe the effect of the depletion on the circadian rhythm of hatching. The phototactic response curves of newly hatched larvae showed that the visual photosensitivity in ocelli of larvae from the carotenoid-depleted eggs was at least 4 log units lower than that of a carotenoid-rich control group. However, the phase-shift experiment revealed that carotenoid depletion did not reduce the photosensitivity in the hatching rhythm. When the hatching rhythm was generated by exposure to a single light pulse in constant darkness, the first peak in the rhythm of the carotenoid-depleted silkworms occurred significantly earlier than that of the carotenoid-rich group, but the following second peaks of both groups were found at the same time. These results suggest that for the silkworm, carotenoid is not involved in photoreception for the hatching rhythm, but is involved in the timing of hatching.

  9. Teaching about ozone layer depletion in Turkey: pedagogical content knowledge of science teachers.

    PubMed

    Bozkurt, Orçun; Kaya, Osman Nafiz

    2008-04-01

    The purpose of this study was to investigate the pedagogical content knowledge of Prospective Science Teachers (PSTs) on the topic of "ozone layer depletion." In order to explore PSTs' subject matter knowledge on ozone layer depletion, they were given a form of multiple-choice test where they needed to write the reasons behind their answers. This test was completed by 140 PSTs in their final year at the College of Education. Individual interviews were carried out with 42 randomly selected PSTs to determine their pedagogical knowledge about ozone layer depletion. Data were obtained from the study which indicate that the PSTs did not have adequate subject matter and pedagogical knowledge to teach the topic of ozone layer depletion to middle school students. It was also evident that the PSTs held various misconceptions related to ozone layer depletion. PSTs' inadequate pedagogical knowledge was found in the areas of the curriculum, learning difficulties of students, and instructional strategies and activities. This study provides some pedagogical implications for the training of science teachers.

  10. Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents

    DTIC Science & Technology

    2006-10-01

    Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents PRINCIPAL INVESTIGATOR: John F. Kalinich, Ph.D...Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy- Metal Tungsten Alloy in Rodents 5b. GRANT NUMBER DAMD17-01-1-0821 5c...ABSTRACT This study investigated the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium (DU) and a heavy-metal tungsten

  11. Tuning Nanocrystal Surface Depletion by Controlling Dopant Distribution as a Route Toward Enhanced Film Conductivity

    NASA Astrophysics Data System (ADS)

    Staller, Corey M.; Robinson, Zachary L.; Agrawal, Ankit; Gibbs, Stephen L.; Greenberg, Benjamin L.; Lounis, Sebastien D.; Kortshagen, Uwe R.; Milliron, Delia J.

    2018-05-01

    Electron conduction through bare metal oxide nanocrystal (NC) films is hindered by surface depletion regions resulting from the presence of surface states. We control the radial dopant distribution in tin-doped indium oxide (ITO) NCs as a means to manipulate the NC depletion width. We find in films of ITO NCs of equal overall dopant concentration that those with dopant-enriched surfaces show decreased depletion width and increased conductivity. Variable temperature conductivity data shows electron localization length increases and associated depletion width decreases monotonically with increased density of dopants near the NC surface. We calculate band profiles for NCs of differing radial dopant distributions and, in agreement with variable temperature conductivity fits, find NCs with dopant-enriched surfaces have narrower depletion widths and longer localization lengths than those with dopant-enriched cores. Following amelioration of NC surface depletion by atomic layer deposition of alumina, all films of equal overall dopant concentration have similar conductivity. Variable temperature conductivity measurements on alumina-capped films indicate all films behave as granular metals. Herein, we conclude that dopant-enriched surfaces decrease the near-surface depletion region, which directly increases the electron localization length and conductivity of NC films.

  12. Tuning Nanocrystal Surface Depletion by Controlling Dopant Distribution as a Route Toward Enhanced Film Conductivity.

    PubMed

    Staller, Corey M; Robinson, Zachary L; Agrawal, Ankit; Gibbs, Stephen L; Greenberg, Benjamin L; Lounis, Sebastien D; Kortshagen, Uwe R; Milliron, Delia J

    2018-05-09

    Electron conduction through bare metal oxide nanocrystal (NC) films is hindered by surface depletion regions resulting from the presence of surface states. We control the radial dopant distribution in tin-doped indium oxide (ITO) NCs as a means to manipulate the NC depletion width. We find in films of ITO NCs of equal overall dopant concentration that those with dopant-enriched surfaces show decreased depletion width and increased conductivity. Variable temperature conductivity data show electron localization length increases and associated depletion width decreases monotonically with increased density of dopants near the NC surface. We calculate band profiles for NCs of differing radial dopant distributions and in agreement with variable temperature conductivity fits find NCs with dopant-enriched surfaces have narrower depletion widths and longer localization lengths than those with dopant-enriched cores. Following amelioration of NC surface depletion by atomic layer deposition of alumina, all films of equal overall dopant concentration have similar conductivity. Variable temperature conductivity measurements on alumina-capped films indicate all films behave as granular metals. Herein, we conclude that dopant-enriched surfaces decrease the near-surface depletion region, which directly increases the electron localization length and conductivity of NC films.

  13. Effective fiber hypertrophy in satellite cell-depleted skeletal muscle

    PubMed Central

    McCarthy, John J.; Mula, Jyothi; Miyazaki, Mitsunori; Erfani, Rod; Garrison, Kelcye; Farooqui, Amreen B.; Srikuea, Ratchakrit; Lawson, Benjamin A.; Grimes, Barry; Keller, Charles; Van Zant, Gary; Campbell, Kenneth S.; Esser, Karyn A.; Dupont-Versteegden, Esther E.; Peterson, Charlotte A.

    2011-01-01

    An important unresolved question in skeletal muscle plasticity is whether satellite cells are necessary for muscle fiber hypertrophy. To address this issue, a novel mouse strain (Pax7-DTA) was created which enabled the conditional ablation of >90% of satellite cells in mature skeletal muscle following tamoxifen administration. To test the hypothesis that satellite cells are necessary for skeletal muscle hypertrophy, the plantaris muscle of adult Pax7-DTA mice was subjected to mechanical overload by surgical removal of the synergist muscle. Following two weeks of overload, satellite cell-depleted muscle showed the same increases in muscle mass (approximately twofold) and fiber cross-sectional area with hypertrophy as observed in the vehicle-treated group. The typical increase in myonuclei with hypertrophy was absent in satellite cell-depleted fibers, resulting in expansion of the myonuclear domain. Consistent with lack of nuclear addition to enlarged fibers, long-term BrdU labeling showed a significant reduction in the number of BrdU-positive myonuclei in satellite cell-depleted muscle compared with vehicle-treated muscle. Single fiber functional analyses showed no difference in specific force, Ca2+ sensitivity, rate of cross-bridge cycling and cooperativity between hypertrophied fibers from vehicle and tamoxifen-treated groups. Although a small component of the hypertrophic response, both fiber hyperplasia and regeneration were significantly blunted following satellite cell depletion, indicating a distinct requirement for satellite cells during these processes. These results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust hypertrophic response to mechanical overload that is not dependent on satellite cells. PMID:21828094

  14. Depleted uranium as a backfill for nuclear fuel waste package

    DOEpatents

    Forsberg, C.W.

    1998-11-03

    A method is described for packaging spent nuclear fuel for long-term disposal in a geological repository. At least one spent nuclear fuel assembly is first placed in an unsealed waste package and a depleted uranium fill material is added to the waste package. The depleted uranium fill material comprises flowable particles having a size sufficient to substantially fill any voids in and around the assembly and contains isotopically-depleted uranium in the +4 valence state in an amount sufficient to inhibit dissolution of the spent nuclear fuel from the assembly into a surrounding medium and to lessen the potential for nuclear criticality inside the repository in the event of failure of the waste package. Last, the waste package is sealed, thereby substantially reducing the release of radionuclides into the surrounding medium, while simultaneously providing radiation shielding and increased structural integrity of the waste package. 6 figs.

  15. DOUBLE SHELL TANK (DST) HYDROXIDE DEPLETION MODEL FOR CARBON DIOXIDE ABSORPTION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    OGDEN DM; KIRCH NW

    2007-10-31

    This document generates a supernatant hydroxide ion depletion model based on mechanistic principles. The carbon dioxide absorption mechanistic model is developed in this report. The report also benchmarks the model against historical tank supernatant hydroxide data and vapor space carbon dioxide data. A comparison of the newly generated mechanistic model with previously applied empirical hydroxide depletion equations is also performed.

  16. Depleted UF6 Management Information Network - A resource for the public,

    Science.gov Websites

    Depleted UF6 Management Information Network Web Site is an online repository of information about the U.S ) and DUF6, research and development efforts for beneficial uses of DU, DOE's program for management of line DUF6 Guide DUF6 Guide line Introductory information about depleted uranium: how it is created

  17. Depleted uranium hexafluoride: The source material for advanced shielding systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Quapp, W.J.; Lessing, P.A.; Cooley, C.R.

    1997-02-01

    The U.S. Department of Energy (DOE) has a management challenge and financial liability problem in the form of 50,000 cylinders containing 555,000 metric tons of depleted uranium hexafluoride (UF{sub 6}) that are stored at the gaseous diffusion plants. DOE is evaluating several options for the disposition of this UF{sub 6}, including continued storage, disposal, and recycle into a product. Based on studies conducted to date, the most feasible recycle option for the depleted uranium is shielding in low-level waste, spent nuclear fuel, or vitrified high-level waste containers. Estimates for the cost of disposal, using existing technologies, range between $3.8 andmore » $11.3 billion depending on factors such as the disposal site and the applicability of the Resource Conservation and Recovery Act (RCRA). Advanced technologies can reduce these costs, but UF{sub 6} disposal still represents large future costs. This paper describes an application for depleted uranium in which depleted uranium hexafluoride is converted into an oxide and then into a heavy aggregate. The heavy uranium aggregate is combined with conventional concrete materials to form an ultra high density concrete, DUCRETE, weighing more than 400 lb/ft{sup 3}. DUCRETE can be used as shielding in spent nuclear fuel/high-level waste casks at a cost comparable to the lower of the disposal cost estimates. Consequently, the case can be made that DUCRETE shielded casks are an alternative to disposal. In this case, a beneficial long term solution is attained for much less than the combined cost of independently providing shielded casks and disposing of the depleted uranium. Furthermore, if disposal is avoided, the political problems associated with selection of a disposal location are also avoided. Other studies have also shown cost benefits for low level waste shielded disposal containers.« less

  18. The Perceptual Characteristics of Sodium Chloride to Sodium-Depleted Rats

    PubMed Central

    2017-01-01

    Three experiments assessed potential changes in the rat’s perception of sodium chloride (NaCl) during a state of sodium appetite. In Experiment 1, sodium-sufficient rats licking a range of NaCl concentrations (0.028–0.89M) in 15s trials showed an inverted U-shaped concentration response function peaking at 0.281M. Depleted rats (furosemide) showed an identical function, merely elevated, suggesting altered qualitative or hedonic perception but no change in perceived intensity. In Experiment 2, sodium-depleted rats were tested with NaCl, sodium gluconate, and potassium chloride (KCl; 0.028–0.89M) similar to Experiment 1. KCl was licked at the same rate as water except for a slight elevation at 0.158; sodium gluconate and NaCl were treated similarly, but rats showed more licking for hypertonic sodium gluconate than hypertonic NaCl. Sodium-depleted rats were also tested with NaCl mixed in amiloride (10–300 μM). Amiloride reduced licking but did not alter the shape of the concentration–response function. Collectively, these results suggest that transduction of sodium by epithelial sodium channels (which are blocked by amiloride and are more dominant in sodium gluconate than NaCl transduction) is crucial for the perception of sodium during physiological sodium depletion. In Experiment 3, sodium-deplete rats were tested with NaCl as in Experiment 1 but after taste aversion conditioning to 0.3M NaCl or sucrose. Rats conditioned to avoid NaCl but not sucrose failed to express a sodium appetite, strongly suggesting that NaCl does not undergo a change in taste quality during sodium appetite—rats show no confusion between sucrose and NaCl in this paradigm. PMID:27660150

  19. The Perceptual Characteristics of Sodium Chloride to Sodium-Depleted Rats.

    PubMed

    St John, Steven J

    2017-02-01

    Three experiments assessed potential changes in the rat's perception of sodium chloride (NaCl) during a state of sodium appetite. In Experiment 1, sodium-sufficient rats licking a range of NaCl concentrations (0.028-0.89M) in 15s trials showed an inverted U-shaped concentration response function peaking at 0.281M. Depleted rats (furosemide) showed an identical function, merely elevated, suggesting altered qualitative or hedonic perception but no change in perceived intensity. In Experiment 2, sodium-depleted rats were tested with NaCl, sodium gluconate, and potassium chloride (KCl; 0.028-0.89M) similar to Experiment 1. KCl was licked at the same rate as water except for a slight elevation at 0.158; sodium gluconate and NaCl were treated similarly, but rats showed more licking for hypertonic sodium gluconate than hypertonic NaCl. Sodium-depleted rats were also tested with NaCl mixed in amiloride (10-300 μM). Amiloride reduced licking but did not alter the shape of the concentration-response function. Collectively, these results suggest that transduction of sodium by epithelial sodium channels (which are blocked by amiloride and are more dominant in sodium gluconate than NaCl transduction) is crucial for the perception of sodium during physiological sodium depletion. In Experiment 3, sodium-deplete rats were tested with NaCl as in Experiment 1 but after taste aversion conditioning to 0.3M NaCl or sucrose. Rats conditioned to avoid NaCl but not sucrose failed to express a sodium appetite, strongly suggesting that NaCl does not undergo a change in taste quality during sodium appetite-rats show no confusion between sucrose and NaCl in this paradigm. Published by Oxford University Press on behalf of US Government 2016.

  20. The effect of motivation and positive affect on ego depletion: Replenishment versus release mechanism.

    PubMed

    Zhu, Ze; Li, Jian; Zhang, Bo; Li, Ye; Zhang, Houcan

    2017-12-01

    In this study, 2 experiments were conducted to investigate whether motivation and positive affect can alleviate ego depletion and to elucidate their possible mechanisms. In Experiment 1, a crossing-out-letter task was adapted to reach an ego depletion state for Chinese participants. Participants were then randomly assigned to the extrinsic motivation group, the positive affect group or the depletion control group. After the experimental treatment, a dumbbell task was used to measure participants' remaining self-regulatory resources. The results showed that participants in the motivation and positive affect groups performed better on the dumbbell task than participants in the depletion control group. Experiment 2 was similar to Experiment 1 except that participants were asked to perform an additional unexpected dumbbell task after a neutral video following the above procedure. The results of Experiment 1 were replicated; however, participants' performance on the additional dumbbell task differed. The positive affect group performed better than the depletion control group, indicating an increase in self-regulatory resources and thus supporting the replenishment effect of positive affect. No significant difference was found between the motivation group and the depletion control group. © 2015 International Union of Psychological Science.

  1. Cold Spots in the Martian Polar Regions: Evidence of Carbon Dioxide Depletion?

    NASA Technical Reports Server (NTRS)

    Weiss, Benjamin P.; Ingersoll, Andrew P.

    2000-01-01

    Regions of very low, rapidly varying brightness temperatures have been observed near the martian winter poles by several spacecraft. One possibility is that the CO2 condensation temperature is lowered by depletion of CO2 in the air at the surface. We estimate the rate at which this low-molecular-weight air would disperse into the high-molecular-weight air above and show that it is generally faster than the rate of supply. This dispersal could be prevented if there is a strong temperature inversion (warm air above colder air) near the surface. Without an inversion, the entire atmospheric column could become depleted. However, depleted columns take a long time to form, and they are inconsistent with the rapid fluctuations in the cold spot locations and temperatures. Because low-altitude temperature inversions cannot be ruled out by existing observations, CO2 depletion is still a viable explanation for the martian cold spots.

  2. Myopathic mtDNA Depletion Syndrome Due to Mutation in TK2 Gene.

    PubMed

    Martín-Hernández, Elena; García-Silva, María Teresa; Quijada-Fraile, Pilar; Rodríguez-García, María Elena; Rivera, Henry; Hernández-Laín, Aurelio; Coca-Robinot, David; Fernández-Toral, Joaquín; Arenas, Joaquín; Martín, Miguel A; Martínez-Azorín, Francisco

    2017-01-01

    Whole-exome sequencing was used to identify the disease gene(s) in a Spanish girl with failure to thrive, muscle weakness, mild facial weakness, elevated creatine kinase, deficiency of mitochondrial complex III and depletion of mtDNA. With whole-exome sequencing data, it was possible to get the whole mtDNA sequencing and discard any pathogenic variant in this genome. The analysis of whole exome uncovered a homozygous pathogenic mutation in thymidine kinase 2 gene ( TK2; NM_004614.4:c.323 C>T, p.T108M). TK2 mutations have been identified mainly in patients with the myopathic form of mtDNA depletion syndromes. This patient presents an atypical TK2-related myopathic form of mtDNA depletion syndromes, because despite having a very low content of mtDNA (<20%), she presents a slower and less severe evolution of the disease. In conclusion, our data confirm the role of TK2 gene in mtDNA depletion syndromes and expanded the phenotypic spectrum.

  3. Gate-Tuned Thermoelectric Power in Black Phosphorus.

    PubMed

    Saito, Yu; Iizuka, Takahiko; Koretsune, Takashi; Arita, Ryotaro; Shimizu, Sunao; Iwasa, Yoshihiro

    2016-08-10

    The electric field effect is a useful means of elucidating intrinsic material properties as well as for designing functional devices. The electric-double-layer transistor (EDLT) enables the control of carrier density in a wide range, which is recently proved to be an effective tool for the investigation of thermoelectric properties. Here, we report the gate-tuning of thermoelectric power in a black phosphorus (BP) single crystal flake with the thickness of 40 nm. Using an EDLT configuration, we successfully control the thermoelectric power (S) and find that the S of ion-gated BP reached +510 μV/K at 210 K in the hole depleted state, which is much higher than the reported bulk single crystal value of +340 μV/K at 300 K. We compared this experimental data with the first-principles-based calculation and found that this enhancement is qualitatively explained by the effective thinning of the conduction channel of the BP flake and nonuniformity of the channel owing to the gate operation in a depletion mode. Our results provide new opportunities for further engineering BP as a thermoelectric material in nanoscale.

  4. Identifying water mass depletion in northern Iraq observed by GRACE

    NASA Astrophysics Data System (ADS)

    Mulder, G.; Olsthoorn, T. N.; Al-Manmi, D. A. M. A.; Schrama, E. J. O.; Smidt, E. H.

    2015-03-01

    Observations acquired by Gravity Recovery And Climate Experiment (GRACE) mission indicate a mass loss of 146 ± 6 mm equivalent water height (EWH) in northern Iraq between 2007 and 2009. These data are used as an independent validation of lake mass variations and a rainfall-runoff model, which is based on local geology and climate conditions. Model inputs are precipitation from Tropical Rainfall Measurement Mission (TRMM) observations, and climatic parameters from Global Land Data Assimilation Systems (GLDAS) model parameters. The model is calibrated with observed river discharge and includes a representation of the karstified aquifers in the region to improve model realism. Lake mass variations were derived from Moderate Resolution Imaging Spectroradiometer (MODIS) in combination with satellite altimetry and some in situ data. Our rainfall-runoff model confirms that northern Iraq suffered a drought between 2007 and 2009 and captures the annual cycle and longer trend of the observed GRACE data. The total mass depletion seen by GRACE between 2007 and 2009 is mainly explained by a lake mass depletion of 75 ± 3 mm EWH and a natural groundwater depletion of 39 ± 8 mm EWH. Our findings indicate that anthropogenic groundwater extraction has a minor influence in this region, while a decline in lake mass and natural depletion of groundwater play a key role.

  5. Research Spotlight: Groundwater is being depleted rapidly in California's Central Valley

    NASA Astrophysics Data System (ADS)

    Tretkoff, Ernie

    2011-03-01

    Groundwater is being depleted in California's Central Valley at a rapid rate, according to data from the Gravity Recovery and Climate Experiment (GRACE) satellite. Famiglietti et al. analyzed 78 months of GRACE data covering October 2003 to March 2010 to estimate water storage changes in California's Sacramento and San Joaquin river basins. They found that the basins are losing water at a rate of about 30 millimeters per year equivalent water height, or a total of about 30 cubic kilometers over the 78-month period. Furthermore, they found that two thirds of this loss, or a total of 20 cubic kilometers for the study period, came from groundwater depletion in the Central Valley. Quantifying groundwater depletion can be challenging in many areas because of a lack of monitoring infrastructure and reporting requirements; the study shows that satellite-based monitoring can be a useful way to track groundwater volumes. The authors warn that the current rate of groundwater depletion in the Central Valley may be unsustainable and could have “potentially dire consequences for the economic and food security of the United States.” (Geophysical Research Letters, doi:10.1029/2010GL046442, 2011)

  6. Co-occurring Down syndrome and SUCLA2-related mitochondrial depletion syndrome.

    PubMed

    Couser, Natario L; Marchuk, Daniel S; Smith, Laurie D; Arreola, Alexandra; Kaiser-Rogers, Kathleen A; Muenzer, Joseph; Pandya, Arti; Gucsavas-Calikoglu, Muge; Powell, Cynthia M

    2017-10-01

    Mitochondrial DNA depletion syndrome 5 (MIM 612073) is a rare autosomal recessive disorder caused by homozygous or compound heterozygous pathogenic variants in the beta subunit of the succinate-CoA ligase gene located within the 13q14 band. We describe two siblings of Hispanic descent with SUCLA2-related mitochondrial depletion syndrome (encephalomyopathic form with methylmalonic aciduria); the older sibling is additionally affected with trisomy 21. SUCLA2 sequencing identified homozygous p.Arg284Cys pathogenic variants in both patients. This mutation has previously been identified in four individuals of Italian and Caucasian descent. The older sibling with concomitant disease has a more severe phenotype than what is typically described in patients with either SUCLA2-related mitochondrial depletion syndrome or Down syndrome alone. The younger sibling, who has a normal female chromosome complement, is significantly less affected compared to her brother. While the clinical and molecular findings have been reported in about 50 patients affected with a deficiency of succinate-CoA ligase caused by pathogenic variants in SUCLA2, this report describes the first known individual affected with both a mitochondrial depletion syndrome and trisomy 21. © 2017 Wiley Periodicals, Inc.

  7. Geological conditions of safe long-term storage and disposal of depleted uranium hexafluoride

    NASA Astrophysics Data System (ADS)

    Laverov, N. P.; Velichkin, V. I.; Omel'Yanenko, B. I.; Yudintsev, S. V.; Tagirov, B. R.

    2010-08-01

    The production of enriched uranium used in nuclear weapons and fuel for atomic power plants is accompanied by the formation of depleted uranium (DU), the amount of which annually increases by 35-40 kt. To date, more than 1.6 Mt DU has accumulated in the world. The main DU mass is stored as environ-mentally hazardous uranium hexafluoride (UF6), which is highly volatile and soluble in water with the formation of hydrofluoric acid. To ensure safe UF6 storage, it is necessary to convert this compound in chemically stable phases. The industrial reprocessing of UF6 into U3O8 and HF implemented in France is highly expensive. We substantiate the expediency of long-term storage of depleted uranium hexafluoride in underground repositories localized in limestone. On the basis of geochemical data and thermodynamic calculations, we show that interaction in the steel container-UF6-limestone-groundwater system gives rise to the development of a slightly alkaline reductive medium favorable for chemical reaction with formation of uraninite (UO2) and fluorite (CaF2). The proposed engineering solution not only ensures safe DU storage but also makes it possible to produce uraninite, which can be utilized, if necessary, in fast-neutron reactors. In the course of further investigations aimed at safe maintenance of DU, it is necessary to study the kinetics of conversion of UF6 into stable phases, involving laboratory and field experiments.

  8. 26 CFR 1.612-3 - Depletion; treatment of bonus and advanced royalty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Depletion; treatment of bonus and advanced royalty. 1.612-3 Section 1.612-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.612-3 Depletion; treatment...

  9. Structural modeling and optimization of a joined-wing configuration of a High-Altitude Long-Endurance (HALE) aircraft

    NASA Astrophysics Data System (ADS)

    Kaloyanova, Valentina B.

    Recent research trends have indicated an interest in High-Altitude, Long-Endurance (HALE) aircraft as a low-cost alternative to certain space missions, such as telecommunication relay, environmental sensing and military reconnaissance. HALE missions require a light vehicle flying at low speed in the stratosphere at altitudes of 60,000-80,000 ft, with a continuous loiter time of up to several days. To provide high lift and low drag at these high altitudes, where the air density is low, the wing area should be increased, i.e., high-aspect-ratio wings are necessary. Due to its large span and lightweight, the wing structure is very flexible. To reduce the structural deformation, and increase the total lift in a long-spanned wing, a sensorcraft model with a joined-wing configuration, proposed by AFRL, is employed. The joined-wing encompasses a forward wing, which is swept back with a positive dihedral angle, and connected with an aft wing, which is swept forward. The joined-wing design combines structural strength, high aerodynamic performance and efficiency. As a first step to study the joined-wing structural behavior an 1-D approximation model is developed. The 1-D approximation is a simple structural model created using ANSYS BEAM4 elements to present a possible approach for the aerodynamics-structure coupling. The pressure loads from the aerodynamic analysis are integrated numerically to obtain the resultant aerodynamic forces and moments (spanwise lift and pitching moment distributions, acting at the aerodynamic center). These are applied on the 1-D structural model. A linear static analysis is performed under this equivalent load, and the deformed shape of the 1-D model is used to obtain the deformed shape of the actual 3-D joined wing, i.e. deformed aerodynamic surface grid. To date in the existing studies, only simplified structural models have been examined. In the present work, in addition to the simple 1-D beam model, a semi-monocoque structural model is

  10. Radiosensitization of Hypoxic Tumor Cells by Depletion of Intracellular Glutathione

    NASA Astrophysics Data System (ADS)

    Bump, Edward A.; Yu, Ning Y.; Brown, J. Martin

    1982-08-01

    Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.

  11. Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bump, E.A.; Yu, N.Y.; Brown, J.M.

    1982-08-06

    Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.

  12. Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience.

    PubMed

    Robinson, Oliver J; Cools, Roshan; Sahakian, Barbara J

    2012-01-01

    We have previously shown that tryptophan depletion enhances punishment but not reward prediction (Cools et al. in Neuropsychopharmacology 33:2291-2299, 2008b). This provided evidence for a valence-specific role of serotonin (which declines under depleted tryptophan) in aversive processing. Recent theoretical (Dayan and Huys in PLoS Comput Biol 4:e4, 2008) and experimental (Crockett et al. in J Neurosci 29:11993-11999, 2009) approaches have, however, further specified this role by showing that serotonin is critical for punishment-induced inhibition. We sought to examine the role of serotonin in punishment-induced inhibition. We also examined the impact of induced mood on this effect to assess whether effects of tryptophan depletion on affective inhibition are moderated by mood. Healthy females consumed a balanced amino acid mixture with (N = 20) or without (N = 21) the serotonin precursor tryptophan. Each subject completed either negative or neutral mood induction. All subjects completed the reward and punishment reversal learning task adopted in the previous study. We demonstrate a punishment prediction impairment in individuals who consumed tryptophan which was absent in individuals who were depleted of tryptophan. This effect was impervious to mood state. Our results suggest that serotonin promotes the inhibition of responses to punishing outcomes. This may lead to reduced punishment prediction accuracy in the presence of tryptophan and may contribute to resilience to affective disorders. Reduction of serotonin via tryptophan depletion then removes this inhibition. As such, we highlight a mechanism by which reduced serotonin can contribute to disorders of impulsivity and compulsivity as well as disorders of emotion.

  13. Momentum-Resolved Observation of Thermal and Quantum Depletion in a Bose Gas

    NASA Astrophysics Data System (ADS)

    Chang, R.; Bouton, Q.; Cayla, H.; Qu, C.; Aspect, A.; Westbrook, C. I.; Clément, D.

    2016-12-01

    We report on the single-atom-resolved measurement of the distribution of momenta ℏk in a weakly interacting Bose gas after a 330 ms time of flight. We investigate it for various temperatures and clearly separate two contributions to the depletion of the condensate by their k dependence. The first one is the thermal depletion. The second contribution falls off as k-4, and its magnitude increases with the in-trap condensate density as predicted by the Bogoliubov theory at zero temperature. These observations suggest associating it with the quantum depletion. How this contribution can survive the expansion of the released interacting condensate is an intriguing open question.

  14. Review of analytical models to stream depletion induced by pumping: Guide to model selection

    NASA Astrophysics Data System (ADS)

    Huang, Ching-Sheng; Yang, Tao; Yeh, Hund-Der

    2018-06-01

    Stream depletion due to groundwater extraction by wells may cause impact on aquatic ecosystem in streams, conflict over water rights, and contamination of water from irrigation wells near polluted streams. A variety of studies have been devoted to addressing the issue of stream depletion, but a fundamental framework for analytical modeling developed from aquifer viewpoint has not yet been found. This review shows key differences in existing models regarding the stream depletion problem and provides some guidelines for choosing a proper analytical model in solving the problem of concern. We introduce commonly used models composed of flow equations, boundary conditions, well representations and stream treatments for confined, unconfined, and leaky aquifers. They are briefly evaluated and classified according to six categories of aquifer type, flow dimension, aquifer domain, stream representation, stream channel geometry, and well type. Finally, we recommend promising analytical approaches that can solve stream depletion problem in reality with aquifer heterogeneity and irregular geometry of stream channel. Several unsolved stream depletion problems are also recommended.

  15. Structurally Resolved Abundances and Depletions in the Rho OPH Cloud

    NASA Astrophysics Data System (ADS)

    Seab, C.

    1995-07-01

    The mechanism that determines the pattern of depletion ofelements in the interstellar medium has been a problem for along time. It is clear that some of the most refractoryelements such as Si, Fe, and Mg, are heavily depleted onto theinterstellar grains. On the other hand, some elements such asS and Zn are normally either undepleted or very lightlydepleted. The difference between the two cases is notunderstood. We propose to address this question with adetailed study of the depletion patterns in the Rho Ophiuchicloud. This study is strongly based on a combination of thecapabilities of two modern instruments: the GHRS for high-resolution UV data, and the Ultra High Resolution Facility(UHRF) of the AAT. This instrument has been used to obtain NaI line profiles in the Rho Oph cloud with a resolution ofR=1,000,000. The combination of these two types of data willbe used to resolve the velocity structure of the elementdepletions in the cloud.

  16. TOPEX electrical power system

    NASA Technical Reports Server (NTRS)

    Chetty, P. R. K.; Roufberg, Lew; Costogue, Ernest

    1991-01-01

    The TOPEX mission requirements which impact the power requirements and analyses are presented. A description of the electrical power system (EPS), including energy management and battery charging methods that were conceived and developed to meet the identified satellite requirements, is included. Analysis of the TOPEX EPS confirms that all of its electrical performance and reliability requirements have been met. The TOPEX EPS employs the flight-proven modular power system (MPS) which is part of the Multimission Modular Spacecraft and provides high reliability, abbreviated development effort and schedule, and low cost. An energy balance equation, unique to TOPEX, has been derived to confirm that the batteries will be completely recharged following each eclipse, under worst-case conditions. TOPEX uses three NASA Standard 50AH Ni-Cd batteries, each with 22 cells in series. The MPS contains battery charge control and protection based on measurements of battery currents, voltages, temperatures, and computed depth-of-discharge. In case of impending battery depletion, the MPS automatically implements load shedding.

  17. Increase in type II collagen turnover after iron depletion in patients with hereditary haemochromatosis.

    PubMed

    Richette, Pascal; Eymard, Claire; Deberg, Michelle; Vidaud, Dominique; de Kerguenec, Caroline; Valla, Dominique; Vicaut, Eric; Bardin, Thomas; Henrotin, Yves

    2010-04-01

    To determine the effects of iron depletion on serum levels of joint biomarkers and on joint symptoms in patients with hereditary haemochromatosis (HH). Levels of biomarkers were measured in 18 patients with HH at the time of diagnosis and after iron depletion. The markers were type II collagen degradation (Coll2-1) and its nitrated form (Coll2-1NO(2)), type II procollagen synthesis (CPII), MPO, COMP and HA. For each patient, demographic data were collected and the global joint pain (visual analogue scale) was assessed before and after iron depletion by phlebotomy. A total of 18 patients [10 males; mean (s.d.) age 48 (11) years] were homozygous for the C282Y mutation. No patient had liver dysfunction. Ferritin level before iron removal was 627.5 (range 133-3276) microg/l, and duration of the iron depletion phase was 295 (70-670) days. Serum levels of both Coll2-1 and CPII were significantly increased from diagnosis after iron depletion: 80.1 (55.6-113.5) vs 96.0 (48.8-136.3) nM (P = 0.004) and 731.4 (374.2-1012.3) vs 812.8 (535.8-1165.6) ng/ml (P = 0.03), respectively. Levels of other biomarkers were not modified by iron depletion. Ferritin level, which at baseline was correlated with body iron store (r = 0.63; P = 0.008), was significantly correlated with HA level measured before iron depletion (r = 0.60; P = 0.01). Global joint pain was not correlated with ferritin concentration and did not significantly decrease after iron depletion: 43 (19-73) vs 36 (16-67) mm (P = 0.07). In patients with HH, cartilage homoeostasis is modified by iron excess and an increase in type II collagen turnover occurs after excess iron removal.

  18. Selective T cell-depleted haploidentical hematopoietic stem cell transplantation for relapsed/refractory neuroblastoma.

    PubMed

    Liu, Anthony P Y; Lee, Pamela P W; Kwok, Janette S Y; Leung, Rock Y Y; Chiang, Alan K S; Ha, Shau-Yin; Cheuk, Daniel K L; Chan, Godfrey C F

    2018-06-19

    Relapsed/refractory NB carries a bleak outcome, warranting novel treatment options. HaploHSCT induces a graft-versus-NB effect via natural killer cell alloreactivity. Review of patients with relapsed/refractory NB who underwent haploHSCT with ex vivo T-cell depletion in our unit from 2013 through 2018. Ten patients were identified (male=5; median age at haploHSCT=6.45 y, range: 3.49-11.02 y). Indications were relapsed in 7 and refractoriness in 3; disease status at haploHSCT was CR in 2, PR in 6, and PD in 2. All patients received peripheral blood stem cell grafts after ex vivo T-cell depletion (CD3/CD19-depletion=1; TCR-αβ/CD19-depletion=4; CD3/CD45RA-depletion=4; and TCR-αβ/CD45RA-depletion=1). Conditioning regimens were fludarabine-based. Neutrophils engrafted on median D + 10 (range: D + 9 to +13), and platelets engrafted (≥20 × 10 9 /L) on median D + 8 (range: D + 5 to D + 14). Early T- and NK-cell recovery were evident. Of the 10 patients, acute rejection developed in 1 (who died of PD despite rescue HSCT), and 1 died of sepsis before engraftment; 8 experienced full donor-chimerism post-HSCT. Among the 8, 6 experienced CR, 1 died of PD, and 1 died of pulmonary hypertensive crisis before evaluation. At publication, 4 were in remission (2.8, 7.4, 28.5, and 58.9 months). No significant GvHD occurred. HaploHSCT with selective ex vivo T-cell depletion may be a safe and useful salvage strategy for relapsed/refractory NB. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Accelerated SDS depletion from proteins by transmembrane electrophoresis: Impacts of Joule heating.

    PubMed

    Unterlander, Nicole; Doucette, Alan Austin

    2018-02-08

    SDS plays a key role in proteomics workflows, including protein extraction, solubilization and mass-based separations (e.g. SDS-PAGE, GELFrEE). However, SDS interferes with mass spectrometry and so it must be removed prior to analysis. We recently introduced an electrophoretic platform, termed transmembrane electrophoresis (TME), enabling extensive depletion of SDS from proteins in solution with exceptional protein yields. However, our prior TME runs required 1 h to complete, being limited by Joule heating which causes protein aggregation at higher operating currents. Here, we demonstrate effective strategies to maintain lower TME sample temperatures, permitting accelerated SDS depletion. Among these strategies, the use of a magnetic stir bar to continuously agitate a model protein system (BSA) allows SDS to be depleted below 100 ppm (>98% removal) within 10 min of TME operations, while maintaining exceptional protein recovery (>95%). Moreover, these modifications allow TME to operate without any user intervention, improving throughput and robustness of the approach. Through fits of our time-course SDS depletion curves to an exponential model, we calculate SDS depletion half-lives as low as 1.2 min. This promising electrophoretic platform should provide proteomics researchers with an effective purification strategy to enable MS characterization of SDS-containing proteins. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Measured and calculated fast neutron spectra in a depleted uranium and lithium hydride shielded reactor

    NASA Technical Reports Server (NTRS)

    Lahti, G. P.; Mueller, R. A.

    1973-01-01

    Measurements of MeV neutron were made at the surface of a lithium hydride and depleted uranium shielded reactor. Four shield configurations were considered: these were assembled progressively with cylindrical shells of 5-centimeter-thick depleted uranium, 13-centimeter-thick lithium hydride, 5-centimeter-thick depleted uranium, 13-centimeter-thick lithium hydride, 5-centimeter-thick depleted uranium, and 3-centimeter-thick depleted uranium. Measurements were made with a NE-218 scintillation spectrometer; proton pulse height distributions were differentiated to obtain neutron spectra. Calculations were made using the two-dimensional discrete ordinates code DOT and ENDF/B (version 3) cross sections. Good agreement between measured and calculated spectral shape was observed. Absolute measured and calculated fluxes were within 50 percent of one another; observed discrepancies in absolute flux may be due to cross section errors.

  1. 21 CFR 2.125 - Use of ozone-depleting substances in foods, drugs, devices, or cosmetics.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Use of ozone-depleting substances in foods, drugs... Specific Products Subject to the Federal Food, Drug, and Cosmetic Act § 2.125 Use of ozone-depleting substances in foods, drugs, devices, or cosmetics. (a) As used in this section, ozone-depleting substance...

  2. 21 CFR 2.125 - Use of ozone-depleting substances in foods, drugs, devices, or cosmetics.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Use of ozone-depleting substances in foods, drugs... Specific Products Subject to the Federal Food, Drug, and Cosmetic Act § 2.125 Use of ozone-depleting substances in foods, drugs, devices, or cosmetics. (a) As used in this section, ozone-depleting substance...

  3. 21 CFR 2.125 - Use of ozone-depleting substances in foods, drugs, devices, or cosmetics.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Use of ozone-depleting substances in foods, drugs... Specific Products Subject to the Federal Food, Drug, and Cosmetic Act § 2.125 Use of ozone-depleting substances in foods, drugs, devices, or cosmetics. (a) As used in this section, ozone-depleting substance...

  4. 21 CFR 2.125 - Use of ozone-depleting substances in foods, drugs, devices, or cosmetics.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Use of ozone-depleting substances in foods, drugs... Specific Products Subject to the Federal Food, Drug, and Cosmetic Act § 2.125 Use of ozone-depleting substances in foods, drugs, devices, or cosmetics. (a) As used in this section, ozone-depleting substance...

  5. Ego Depletion and the Strength Model of Self-Control: A Meta-Analysis

    ERIC Educational Resources Information Center

    Hagger, Martin S.; Wood, Chantelle; Stiff, Chris; Chatzisarantis, Nikos L. D.

    2010-01-01

    According to the strength model, self-control is a finite resource that determines capacity for effortful control over dominant responses and, once expended, leads to impaired self-control task performance, known as "ego depletion". A meta-analysis of 83 studies tested the effect of ego depletion on task performance and related outcomes,…

  6. Hypopituitarism in primary haemochromatosis; recovery after iron depletion.

    PubMed Central

    Gama, R.; Smith, M. J.; Wright, J.; Marks, V.

    1995-01-01

    We report a case of primary haemochromatosis complicated by anterior hypopituitarism which recovered after aggressive venesection therapy. Reversal of anterior hypopituitarism in haemochromatosis following iron depletion has not been previously described. PMID:7596937

  7. Rb-Sr And Sm-Nd Ages, and Petrogenesis of Depleted Shergottite Northwest Africa 5990

    NASA Technical Reports Server (NTRS)

    Shih, C. Y.; Nyquist, L. E.; Reese, Y.; Irving, A. J.

    2011-01-01

    Northwest Africa (NWA) 5990 is a very fresh Martian meteorite recently found on Hamada du Draa, Morocco and was classified as an olivine-bearing diabasic igneous rock related to depleted shergottites [1]. The study of [1] also showed that NWA 5990 resembles QUE 94201 in chemical, textural and isotopic aspects, except QUE 94201 contains no olivine. The depleted shergottites are characterized by REE patterns that are highly depleted in LREE, older Sm-Nd ages of 327-575 Ma and highly LREE-depleted sources with Nd= +35+48 [2-7]. Age-dating these samples by Sm-Nd and Rb-Sr methods is very challenging because they have been strongly shocked and contain very low abundances of light rare earth elements (Sm and Nd), Rb and Sr. In addition, terrestrial contaminants which are commonly present in desert meteorites will compromise the equilibrium of isotopic systems. Since NWA 5990 is a very fresh meteorite, it probably has not been subject to significant desert weathering and thus is a good sample for isotopic studies. In this report, we present Rb-Sr and Sm-Nd isotopic results for NWA 5990, discuss the correlation of the determined ages with those of other depleted shergottites, especially QUE 94201, and discuss the petrogenesis of depleted shergottites.

  8. Halocarbon ozone depletion and global warming potentials

    NASA Technical Reports Server (NTRS)

    Cox, Richard A.; Wuebbles, D.; Atkinson, R.; Connell, Peter S.; Dorn, H. P.; Derudder, A.; Derwent, Richard G.; Fehsenfeld, F. C.; Fisher, D.; Isaksen, Ivar S. A.

    1990-01-01

    Concern over the global environmental consequences of fully halogenated chlorofluorocarbons (CFCs) has created a need to determine the potential impacts of other halogenated organic compounds on stratospheric ozone and climate. The CFCs, which do not contain an H atom, are not oxidized or photolyzed in the troposphere. These compounds are transported into the stratosphere where they decompose and can lead to chlorine catalyzed ozone depletion. The hydrochlorofluorocarbons (HCFCs or HFCs), in particular those proposed as substitutes for CFCs, contain at least one hydrogen atom in the molecule, which confers on these compounds a much greater sensitivity toward oxidation by hydroxyl radicals in the troposphere, resulting in much shorter atmospheric lifetimes than CFCs, and consequently lower potential for depleting ozone. The available information is reviewed which relates to the lifetime of these compounds (HCFCs and HFCs) in the troposphere, and up-to-date assessments are reported of the potential relative effects of CFCs, HCFCs, HFCs, and halons on stratospheric ozone and global climate (through 'greenhouse' global warming).

  9. Choice and ego-depletion: the moderating role of autonomy.

    PubMed

    Moller, Arlen C; Deci, Edward L; Ryan, Richard M

    2006-08-01

    The self-regulatory strength model maintains that all acts of self-regulation, self-control, and choice result in a state of fatigue called ego-depletion. Self-determination theory differentiates between autonomous regulation and controlled regulation. Because making decisions represents one instance of self-regulation, the authors also differentiate between autonomous choice and controlled choice. Three experiments support the hypothesis that whereas conditions representing controlled choice would be egodepleting, conditions that represented autonomous choice would not. In Experiment 3, the authors found significant mediation by perceived self-determination of the relation between the choice condition (autonomous vs. controlled) and ego-depletion as measured by performance.

  10. Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.

    PubMed

    Morley, Kirsten C; Li, Kong M; Hunt, Glenn E; Mallet, Paul E; McGregor, Iain S

    2004-06-01

    Cannabinoid-MDMA interactions were examined in male Wistar rats. MDMA (4 x 5 mg/kg or 2 x 10 mg/kg over 4 h on each of 2 days) was administered with or without Delta 9-tetrahydrocannabinol (THC) (4 x 2.5 mg/kg), the synthetic cannabinoid receptor agonist CP 55,940 (2 x 0.1 or 0.2 mg/kg) or the cannabinoid receptor antagonist SR 141716 (2 x 5 mg/kg). Co-administered Delta 9-THC and CP 55,940 but not SR 141716 prevented MDMA-induced hyperthermia, causing a powerful hypothermia. Co-administered Delta 9-THC, CP 55,940 and SR 141716 all tended to decrease MDMA-induced hyperactivity. Co-administered Delta 9-THC provided protection against the long-term increases in anxiety seen in the emergence test, but not the social interaction test, 6 weeks after MDMA treatment. Co-administered Delta 9-THC and CP 55,940, but not SR 141716, partly prevented the long-term 5-HT and 5-HIAA depletion caused by MDMA in various brain regions. SR 141716 administered with CP 55,940 and MDMA prevented the hypothermic response to the CP 55,940/MDMA combination but did not alter the CP 55,940 attenuation of MDMA-induced 5-HT depletion. These results suggest a partial protective effect of co-administered cannabinoid receptor agonists on MDMA-induced 5-HT depletion and long-term anxiety. This action appears to operate independently of cannabinoid CB1 receptors.

  11. 21 CFR 2.125 - Use of ozone-depleting substances in foods, drugs, devices, or cosmetics.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Use of ozone-depleting substances in foods, drugs... Specific Products Subject to the Federal Food, Drug, and Cosmetic Act § 2.125 Use of ozone-depleting... 75 FR 19241, Apr. 14, 2010. (a) As used in this section, ozone-depleting substance (ODS) means any...

  12. Groundwater depletion and sustainability of irrigation in the US High Plains and Central Valley

    USGS Publications Warehouse

    Scanlon, Bridget R.; Faunt, Claudia; Longuevergne, Laurent; Reedy, Robert C.; Alley, William M.; McGuire, Virginia L.; McMahon, Peter B.

    2012-01-01

    Aquifer overexploitation could significantly impact crop production in the United States because 60% of irrigation relies on groundwater. Groundwater depletion in the irrigated High Plains and California Central Valley accounts for ∼50% of groundwater depletion in the United States since 1900. A newly developed High Plains recharge map shows that high recharge in the northern High Plains results in sustainable pumpage, whereas lower recharge in the central and southern High Plains has resulted in focused depletion of 330 km3 of fossil groundwater, mostly recharged during the past 13,000 y. Depletion is highly localized with about a third of depletion occurring in 4% of the High Plains land area. Extrapolation of the current depletion rate suggests that 35% of the southern High Plains will be unable to support irrigation within the next 30 y. Reducing irrigation withdrawals could extend the lifespan of the aquifer but would not result in sustainable management of this fossil groundwater. The Central Valley is a more dynamic, engineered system, with north/south diversions of surface water since the 1950s contributing to ∼7× higher recharge. However, these diversions are regulated because of impacts on endangered species. A newly developed Central Valley Hydrologic Model shows that groundwater depletion since the 1960s, totaling 80 km3, occurs mostly in the south (Tulare Basin) and primarily during droughts. Increasing water storage through artificial recharge of excess surface water in aquifers by up to 3 km3 shows promise for coping with droughts and improving sustainability of groundwater resources in the Central Valley.

  13. Groundwater depletion and sustainability of irrigation in the US High Plains and Central Valley

    USGS Publications Warehouse

    Scanlon, Bridget R.; Faunt, Claudia C.; Longuevergne, Laurent; Reedy, Robert C.; Alley, William M.; McGuire, Virginia L.; McMahon, Peter B.

    2012-01-01

    Aquifer overexploitation could significantly impact crop production in the United States because 60% of irrigation relies on groundwater. Groundwater depletion in the irrigated High Plains and California Central Valley accounts for ~50% of groundwater depletion in the United States since 1900. A newly developed High Plains recharge map shows that high recharge in the northern High Plains results in sustainable pumpage, whereas lower recharge in the central and southern High Plains has resulted in focused depletion of 330 km3 of fossil groundwater, mostly recharged during the past 13,000 y. Depletion is highly localized with about a third of depletion occurring in 4% of the High Plains land area. Extrapolation of the current depletion rate suggests that 35% of the southern High Plains will be unable to support irrigation within the next 30 y. Reducing irrigation withdrawals could extend the lifespan of the aquifer but would not result in sustainable management of this fossil groundwater. The Central Valley is a more dynamic, engineered system, with north/south diversions of surface water since the 1950s contributing to ~7× higher recharge. However, these diversions are regulated because of impacts on endangered species. A newly developed Central Valley Hydrologic Model shows that groundwater depletion since the 1960s, totaling 80 km3, occurs mostly in the south (Tulare Basin) and primarily during droughts. Increasing water storage through artificial recharge of excess surface water in aquifers by up to 3 km3 shows promise for coping with droughts and improving sustainability of groundwater resources in the Central Valley.

  14. Groundwater depletion and sustainability of irrigation in the US High Plains and Central Valley

    PubMed Central

    Scanlon, Bridget R.; Faunt, Claudia C.; Longuevergne, Laurent; Reedy, Robert C.; Alley, William M.; McGuire, Virginia L.; McMahon, Peter B.

    2012-01-01

    Aquifer overexploitation could significantly impact crop production in the United States because 60% of irrigation relies on groundwater. Groundwater depletion in the irrigated High Plains and California Central Valley accounts for ∼50% of groundwater depletion in the United States since 1900. A newly developed High Plains recharge map shows that high recharge in the northern High Plains results in sustainable pumpage, whereas lower recharge in the central and southern High Plains has resulted in focused depletion of 330 km3 of fossil groundwater, mostly recharged during the past 13,000 y. Depletion is highly localized with about a third of depletion occurring in 4% of the High Plains land area. Extrapolation of the current depletion rate suggests that 35% of the southern High Plains will be unable to support irrigation within the next 30 y. Reducing irrigation withdrawals could extend the lifespan of the aquifer but would not result in sustainable management of this fossil groundwater. The Central Valley is a more dynamic, engineered system, with north/south diversions of surface water since the 1950s contributing to ∼7× higher recharge. However, these diversions are regulated because of impacts on endangered species. A newly developed Central Valley Hydrologic Model shows that groundwater depletion since the 1960s, totaling 80 km3, occurs mostly in the south (Tulare Basin) and primarily during droughts. Increasing water storage through artificial recharge of excess surface water in aquifers by up to 3 km3 shows promise for coping with droughts and improving sustainability of groundwater resources in the Central Valley. PMID:22645352

  15. Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance

    PubMed Central

    Robertson, Charles M.; Perrone, Erin E; McConnell, Kevin W.; Dunne, W. Michael; Boody, Barrett; Brahmbhatt, Tejal; Diacovo, M. Julia; Van Rooijen, Nico; Hogue, Lisa A.; Cannon, Carolyn L.; Buchman, Timothy G.; Hotchkiss, Richard S.; Coopersmith, Craig M.

    2008-01-01

    Background Staphylococcus aureus is the most common cause of healthcare-associated pneumonia. Despite the significant morbidity and mortality associated with the disease, animal models of S. aureus pneumonia are rare. Materials and Methods We examined the pathogenicity of four different strains of S. aureus (both methicillin-sensitive and resistant as well as Panton-Valentine leukocidin positive and negative) in four strains of immunocompetent inbred and outbred mice (FVB/N, C57Bl/6, Balb/c, ND4, n=148). The immunologic basis for the development of murine S. aureus pneumonia was then determined by selectively depleting neutrophils, lymphocytes, or pulmonary macrophages prior to the onset of infection. An additional cohort of animals was rendered immunosuppressed by induction of abdominal sepsis via cecal ligation and puncture 2, 4 or 7 days prior to the onset of pneumonia. Results Nearly all immunocompetent mice survived, regardless of which strain of S. aureus was used or which strain of mouse was infected. Among animals with immune depletion or prior immunosuppression, survival was decreased only following neutrophil depletion (26% vs. 90% alive at 7 days, p<0.0001). Compared to immunocompetent animals, neutrophil-depleted mice with S. aureus pneumonia had delayed pulmonary bacterial clearance at 16 and 40 hours but had no difference in levels of bacteremia. Neutrophil-depleted mice also had elevated levels of pulmonary MCP-1 (822 pg/ml vs. 150 pg/ml, p<0.05). In contrast, pulmonary histologic appearance was similar in both groups as was dry/wet lung weight. Conclusions These results suggest that neutrophils play a critical role in the host response to S. aureus pneumonia, and the survival differences observed in neutrophil-depleted mice are associated with alterations in bacterial clearance and pulmonary cytokine response. PMID:18621398

  16. Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.

    PubMed

    Robertson, Charles M; Perrone, Erin E; McConnell, Kevin W; Dunne, W Michael; Boody, Barrett; Brahmbhatt, Tejal; Diacovo, M Julia; Van Rooijen, Nico; Hogue, Lisa A; Cannon, Carolyn L; Buchman, Timothy G; Hotchkiss, Richard S; Coopersmith, Craig M

    2008-12-01

    Staphylococcus aureus is the most common cause of healthcare-associated pneumonia. Despite the significant morbidity and mortality associated with the disease, animal models of S. aureus pneumonia are rare. We examined the pathogenicity of four different strains of S. aureus (both methicillin-sensitive and -resistant as well as Panton-Valentine leukocidin-positive and -negative) in four strains of immunocompetent inbred and outbred mice (FVB/N, C57Bl/6, BALB/c, ND4; n = 148). The immunological basis for the development of murine S. aureus pneumonia was then determined by selectively depleting neutrophils, lymphocytes, or pulmonary macrophages prior to the onset of infection. An additional cohort of animals was rendered immunosuppressed by induction of abdominal sepsis via cecal ligation and puncture 2, 4, or 7 d prior to the onset of pneumonia. Nearly all immunocompetent mice survived, regardless of which strain of S. aureus was used or which strain of mouse was infected. Among animals with immune depletion or prior immunosuppression, survival was decreased only following neutrophil depletion (26% versus 90% alive at 7 d, P < 0.0001). Compared to immunocompetent animals, neutrophil-depleted mice with S. aureus pneumonia had delayed pulmonary bacterial clearance at 16 and 40 h but had no difference in levels of bacteremia. Neutrophil-depleted mice also had elevated levels of pulmonary monocyte chemotactic protein-1 (822 pg/mL versus 150 pg/mL, P < 0.05). In contrast, pulmonary histological appearance was similar in both groups as was dry/wet lung weight. These results suggest that neutrophils play a critical role in the host response to S. aureus pneumonia, and the survival differences observed in neutrophil-depleted mice are associated with alterations in bacterial clearance and pulmonary cytokine response.

  17. Evaluating groundwater depletion as computed by a global water model

    NASA Astrophysics Data System (ADS)

    Schuh, Carina; Doell, Petra; Mueller Schmied, Hannes; Portmann, Felix

    2013-04-01

    When groundwater abstraction occurs faster than its replenishment over a long time and in a large area, the result is an overexploitation or depletion of groundwater. The problem is aggravated in areas where a growing population relies on freshwater resources for an intensive irrigation agriculture that is meant to guarantee food security. Especially in semi-arid and arid regions, the dominant use for groundwater is irrigation, reaching more than 95% of total water use. Therefore, the hot spots for groundwater depletion are the world's major irrigation areas like the central United States, north-western India and north China. Groundwater depletion presents a major threat to securing agricultural productivity and domestic water supply in these parts of the world. Besides, the environmental consequences that accompany the abstraction of groundwater are severe. Within the scientific community there is a common understanding that high-quality data on globally existing groundwater resources are deficient. In order to allow a sustainable management of the world's available groundwater resources, especially in areas under current water stress, the quantification of groundwater depletion is of high importance. WaterGAP (Water - Global Assessment and Prognosis) is a global model of water availability and water use which can serve to estimate the impact of groundwater and surface water withdrawals on groundwater storage. The new WaterGAP version 2.2a was modified to allow for an improved analysis of groundwater storage changes in semi-arid and arid regions. Now, groundwater recharge from surface water bodies is simulated in semi-arid and arid areas. Estimation of net groundwater abstractions was modified with respect of irrigation water use efficiency for groundwater and return flow fractions. In addition, irrigation consumptive use has been set to 70% of optimal irrigation consumptive use, assuming deficit irrigation to prevail in these parts of the world. Based on time

  18. Serotonin depletion can enhance the cerebrovascular responses induced by cortical spreading depression via the nitric oxide pathway.

    PubMed

    Saengjaroentham, Chonlawan; Supornsilpchai, Weera; Ji-Au, Wilawan; Srikiatkhachorn, Anan; Maneesri-le Grand, Supang

    2015-02-01

    Serotonin (5-HT) is an important neurotransmitter involved in the control of neural and vascular responses. 5-HT depletion can induce several neurological disorders, including migraines. Studies on a cortical spreading depression (CSD) migraine animal model showed that the cortical neurons sensitivity, vascular responses, and nitric oxide (NO) production were significantly increased in 5-HT depletion. However, the involvement of NO in the cerebrovascular responses in 5-HT depletion remains unclear. This study aimed to investigate the role of NO in the CSD-induced alterations of cerebral microvessels in 5-HT depletion. Rats were divided into four groups: control, control with L-NAME treatment, 5-HT depleted, and 5-HT depleted with L-NAME treatment. 5-HT depletion was induced by intraperitoneal injection with para-chlorophenylalanine (PCPA) 3 days before the experiment. The CSD was triggered by KCl application. After the second wave of CSD, N-nitro-l-arginine methyl ester (L-NAME) or saline was intravenously injected into the rats with or without L-NAME treatment groups, respectively. The intercellular adhesion molecules-1 (ICAM-1), cell adhesion molecules-1 (VCAM-1), and the ultrastructural changes of the cerebral microvessels were examined. The results showed that 5-HT depletion significantly increased ICAM-1 and VCAM-1 expressions in the cerebral cortex. The number of endothelial pinocytic vesicles and microvilli was higher in the 5-HT depleted group when compared to the control. Interestingly, L-NAME treatment significantly reduced the abnormalities observed in the 5-HT depleted group. The results of this study demonstrated that an increase of NO production is one of the mechanisms involved in the CSD-induced alterations of the cerebrovascular responses in 5-HT depletion.

  19. The Benefits of Self-Set Goals: Is Ego Depletion Really a Result of Self-Control Failure?

    PubMed Central

    Zahn, Daniela; Rowland, Zarah; Kubiak, Thomas

    2016-01-01

    Research on ego depletion aims at explaining self-control failures in daily life. Both resource models and motivational accounts have been proposed for explanation. The aim of the present research was to test the different assumptions in two dual-task experiments where we operationalized ego depletion as a performance deviation from a self-set goal. In two experiments, we found evidence for this deviation contradicting motivational accounts of ego depletion: Participants experiencing ego depletion set themselves a stricter instead of a more lenient goal than controls, in that they chose to eat less cookies or wanted to perform better. Moreover, only participants without an initial self-control task could adhere to their self-set goal, whereas participants in the ego depletion condition in both experiments could not follow through with their more ambitious intentions. Taken together, our findings demonstrate the importance of goals in ego depletion research. PMID:27280531

  20. Intermittent dynamics in complex systems driven to depletion.

    PubMed

    Escobar, Juan V; Pérez Castillo, Isaac

    2018-03-19

    When complex systems are driven to depletion by some external factor, their non-stationary dynamics can present an intermittent behaviour between relative tranquility and burst of activity whose consequences are often catastrophic. To understand and ultimately be able to predict such dynamics, we propose an underlying mechanism based on sharp thresholds of a local generalized energy density that naturally leads to negative feedback. We find a transition from a continuous regime to an intermittent one, in which avalanches can be predicted despite the stochastic nature of the process. This model may have applications in many natural and social complex systems where a rapid depletion of resources or generalized energy drives the dynamics. In particular, we show how this model accurately describes the time evolution and avalanches present in a real social system.

  1. Adapting to an initial self-regulatory task cancels the ego depletion effect.

    PubMed

    Dang, Junhua; Dewitte, Siegfried; Mao, Lihua; Xiao, Shanshan; Shi, Yucai

    2013-09-01

    The resource-based model of self-regulation provides a pessimistic view of self-regulation that people are destined to lose their self-control after having engaged in any act of self-regulation because these acts deplete the limited resource that people need for successful self-regulation. The cognitive control theory, however, offers an alternative explanation and suggests that the depletion effect reflects switch costs between different cognitive control processes recruited to deal with demanding tasks. This account implies that the depletion effect will not occur once people have had the opportunity to adapt to the self-regulatory task initially engaged in. Consistent with this idea, the present study showed that engaging in a demanding task led to performance deficits on a subsequent self-regulatory task (i.e. the depletion effect) only when the initial demanding task was relatively short but not when it was long enough for participants to adapt. Our results were unrelated to self-efficacy, mood, and motivation. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Electromagnetic fluctuations generated in the boundary layer of laboratory-created ionospheric depletions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Yu; Lei, Jiuhou, E-mail: leijh@ustc.edu.cn; Collaborative Innovation Center of Astronautical Science and Technology, Harbin 150001

    Ionospheric depletions, produced by release of attachment chemicals into the ionosphere, were widely investigated and taken as a potential technique for the artificial modification of space weather. In this work, we reported the experimental evidence of spontaneously generated electromagnetic fluctuations in the boundary layer of laboratory-created ionospheric depletions. These depletions were produced by releasing attachment chemicals into the ambient plasmas. Electron density gradients and sheared flows arose in the boundary layer between the ambient and the negative ions plasmas. These generated electromagnetic fluctuations with fundamental frequency f{sub 0} = 70 kHz lie in the lower hybrid frequency range, and the mode propagates withmore » angles smaller than 90° (0.3π–0.4π) relative to the magnetic field. Our results revealed that these observed structures were most likely due to electromagnetic components of the electron-ion hybrid instability. This research demonstrates that electromagnetic fluctuations also can be excited during active release experiments, which should be considered as an essential ingredient in the boundary layer processes of ionospheric depletions.« less

  3. Too Big to Be Real? No Depleted Core in Holm 15A

    NASA Astrophysics Data System (ADS)

    Bonfini, Paolo; Dullo, Bililign T.; Graham, Alister W.

    2015-07-01

    Partially depleted cores, as measured by core-Sérsic model “break radii,” are typically tens to a few hundred parsecs in size. Here we investigate the unusually large ({R}γ \\prime =0.5 = 4.57 kpc) depleted core recently reported for Holm 15A, the brightest cluster galaxy of Abell 85. We model the one-dimensional (1D) light profile, and also the two-dimensional (2D) image (using Galfit-Corsair, a tool for fitting the core-Sérsic model in 2D). We find good agreement between the 1D and 2D analyses, with minor discrepancies attributable to intrinsic ellipticity gradients. We show that a simple Sérsic profile (with a low index n and no depleted core) plus the known outer exponential “halo” provide a good description of the stellar distribution. We caution that while almost every galaxy light profile will have a radius where the negative logarithmic slope of the intensity profile γ \\prime equals 0.5, this alone does not imply the presence of a partially depleted core within this radius.

  4. Identifying water mass depletion in Northern Iraq observed by GRACE

    NASA Astrophysics Data System (ADS)

    Mulder, G.; Olsthoorn, T. N.; Al-Manmi, D. A. M. A.; Schrama, E. J. O.; Smidt, E. H.

    2014-10-01

    Observations acquired by Gravity Recovery And Climate Experiment (GRACE) mission indicate a mass loss of 31 ± 3 km3 or 130 ± 14 mm in Northern Iraq between 2007 and 2009. This data is used as an independent validation of a hydrologic model of the region including lake mass variations. We developed a rainfall-runoff model for five tributaries of the Tigris River, based on local geology and climate conditions. Model inputs are precipitation from Tropical Rainfall Measurement Mission (TRMM) observations, and potential evaporation from GLDAS model parameters. Our model includes a representation of the karstified aquifers that cause large natural groundwater variations in this region. Observed river discharges were used to calibrate our model. In order to get the total mass variations, we corrected for lake mass variations derived from Moderate Resolution Imaging Spectroradiometer (MODIS) in combination with satellite altimetry and some in-situ data. Our rainfall-runoff model confirms that Northern Iraq suffered a drought between 2007 and 2009 and is consistent with the mass loss observed by GRACE over that period. Also, GRACE observed the annual cycle predicted by the rainfall-runoff model. The total mass depletion seen by GRACE between 2007 and 2009 is mainly explained by a lake mass depletion of 74 ± 4 mm and a natural groundwater depletion of 37 ± 6 mm. Our findings indicate that man-made groundwater extraction has a minor influence in this region while depletion of lake mass and geology play a key role.

  5. Tank depletion flow controller

    DOEpatents

    Georgeson, Melvin A.

    1976-10-26

    A flow control system includes two bubbler tubes installed at different levels within a tank containing such as radioactive liquid. As the tank is depleted, a differential pressure transmitter monitors pressure differences imparted by the two bubbler tubes at a remote, shielded location during uniform time intervals. At the end of each uniform interval, balance pots containing a dense liquid are valved together to equalize the pressures. The resulting sawtooth-shaped signal generated by the differential pressure transmitter is compared with a second sawtooth signal representing the desired flow rate during each time interval. Variations in the two signals are employed by a control instrument to regulate flow rate.

  6. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project.

    PubMed

    Knoops, Kim T B; de Groot, Lisette C P G M; Kromhout, Daan; Perrin, Anne-Elisabeth; Moreiras-Varela, Olga; Menotti, Alessandro; van Staveren, Wija A

    2004-09-22

    Dietary patterns and lifestyle factors are associated with mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer, but few studies have investigated these factors in combination. To investigate the single and combined effect of Mediterranean diet, being physically active, moderate alcohol use, and nonsmoking on all-cause and cause-specific mortality in European elderly individuals. The Healthy Ageing: a Longitudinal study in Europe (HALE) population, comprising individuals enrolled in the Survey in Europe on Nutrition and the Elderly: a Concerned Action (SENECA) and the Finland, Italy, the Netherlands, Elderly (FINE) studies, includes 1507 apparently healthy men and 832 women, aged 70 to 90 years in 11 European countries. This cohort study was conducted between 1988 and 2000. Ten-year mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer. During follow-up, 935 participants died: 371 from cardiovascular diseases, 233 from cancer, and 145 from other causes; for 186, the cause of death was unknown. Adhering to a Mediterranean diet (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.68-0.88), moderate alcohol use (HR, 0.78; 95% CI, 0.67-0.91), physical activity (HR, 0.63; 95% CI, 0.55-0.72), and nonsmoking (HR, 0.65; 95% CI, 0.57-0.75) were associated with a lower risk of all-cause mortality (HRs controlled for age, sex, years of education, body mass index, study, and other factors). Similar results were observed for mortality from coronary heart disease, cardiovascular diseases, and cancer. The combination of 4 low risk factors lowered the all-cause mortality rate to 0.35 (95% CI, 0.28-0.44). In total, lack of adherence to this low-risk pattern was associated with a population attributable risk of 60% of all deaths, 64% of deaths from coronary heart disease, 61% from cardiovascular diseases, and 60% from cancer. Among individuals aged 70 to 90 years, adherence to a Mediterranean diet and healthful

  7. Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice

    PubMed Central

    Willard, Amanda M.; Bouchard, Rachel S.; Gittis, Aryn H.

    2015-01-01

    Parkinson’s disease (PD) is a movement disorder whose cardinal motor symptoms arise due to the progressive loss of dopamine. Although this dopamine loss typically progresses slowly over time, currently there are very few animal models that enable incremental dopamine depletion over time within the same animal. This type of gradual dopamine depletion model would be useful in studies aimed at the prodromal phase of PD, when dopamine levels are pathologically low but motor symptoms have not yet presented. Utilizing the highly characterized neurotoxin 6-hydroxydopamine (6-OHDA), we have developed a paradigm to gradually deplete dopamine levels in the striatum over a user-defined time course – spanning weeks to months – in C57BL/6 mice. Dopamine depletions were achieved by administration of five low dose injections (0.75 µg) of 6-OHDA through an implanted intracranial bilateral cannula targeting the medial forebrain bundle. Levels of dopamine within the striatum declined linearly with successive injections, quantified using tyrosine hydroxylase immunostaining and high-performance liquid chromatography. Behavioral testing was carried out at each time point to study the onset and progression of motor impairments as a function of dopamine loss over time. We found that spontaneous locomotion, measured in an open field, was robust to loss of dopamine until ~70% of striatal dopamine was lost. Beyond this point, additional dopamine loss caused a sharp decline in motor performance, reaching a final level comparable to that of acutely depleted mice. Similarly, although rearing behavior was more sensitive to dopamine loss and declined linearly as a function of dopamine levels, it eventually declined to levels similar to that seen in acutely depleted mice. In contrast, motor coordination, measured on a vertical pole task, was only moderately impaired in gradually depleted mice, despite severe impairments observed in acutely depleted mice. These results demonstrate the

  8. Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects

    PubMed Central

    Young, Simon N.

    2013-01-01

    The acute tryptophan depletion (ATD) technique has been used extensively to study the effect of low serotonin in the human brain. This review assesses the validity of a number of published criticisms of the technique and a number of previously unpublished potential criticisms. The conclusion is that ATD can provide useful information when results are assessed in conjunction with results obtained using other techniques. The best-established conclusion is that low serotonin function after tryptophan depletion lowers mood in some people. However, this does not mean that other variables, altered after tryptophan depletion, are necessarily related to low serotonin. Each aspect of brain function has to be assessed separately. Furthermore, a negative tryptophan depletion study does not mean that low serotonin cannot influence the variable studied. This review suggests gaps in knowledge that need to be filled and guidelines for carrying out ATD studies. PMID:23428157

  9. Mid-latitude Ozone Depletion Events Caused by Halogens from the Great Salt Lake in Utah

    NASA Astrophysics Data System (ADS)

    Fibiger, D. L.; Goldberger, L.; Womack, C.; McDuffie, E. E.; Dube, W. P.; Franchin, A.; Middlebrook, A. M.; Thornton, J. A.; Brown, S. S.

    2017-12-01

    Halogens are highly reactive chemicals and play an important role in atmospheric chemistry. They can be involved in many cycles which influence the oxidizing capacity of the atmosphere, including through destruction of ozone (O3). While the influence of halogens on O3 is well documented in the arctic, there are very few observations of O3 depletion driven by halogens in the mid-latitudes. To date, the most comprehensive study observed co-occurring plumes of BrO and depleted O3 near the Dead Sea in 1997. During the Utah Wintertime Fine Particulate Study (UWFPS) in winter 2017, simultaneous measurements of a comprehensive suite of halogen measurements by I- chemical ionization mass spectrometry and O3 from cavity ring-down spectroscopy, both at 1-second time resolution, were taken on a NOAA Twin Otter Aircraft over the Great Salt Lake and in the surrounding valleys. Many O3 depletion events were observed over the lake with O3 values sometimes below the instrument detection limit of 0.5 ppbv. Corresponding increases in BrO and/or ClO were observed. Many of these events were caused by extremely high levels of halogens (up to 1 ppmv Cl2) emitted from the U.S. Magnesium plant on the edge of the lake. The O3 depletion caused by U.S. Magnesium was usually isolated to a distinct vertical layer, but in other cases O3 depletion was vertically mixed and the origin of halogen activation was not immediately clear. The most complete O3 depletion was observed over the lake, but there were smaller events of a few ppbv observed in the adjacent valleys, including the highly populated Salt Lake Valley, with corresponding plumes of BrO and ClO, due to transport from the lake. Additionally, meteorology played a role in the observed O3 depletion. The strongest O3 depletion was observed during inversion events, when there is a low boundary layer and little mixing out of the air above the lake. During non-inversion conditions, only small depletions were observed, covering a much smaller

  10. Peak groundwater depletion in the High Plains Aquifer, projections from 1930 to 2110

    USDA-ARS?s Scientific Manuscript database

    Peak groundwater depletion from overtapping aquifers beyond recharge rates occurs as the depletion rate increases until a peak occurs followed by a decreasing trend as pumping equilibrates towards available recharge. The logistic equation of Hubbert’s study of peak oil is used to project measurement...

  11. A feasibility study of methods for stopping the depletion of ozone over Antarctica

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Ways of stopping the ozone depletion in the ozone hole over Antarctica were studied. The basic objectives were: (1) to define and understand the phenomenon of the ozone hole; (2) to determine possible methods of stopping the ozone depletion; (3) to identify unknowns about the hole and possible solutions. Two basic ways of attacking the problem were identified. First is replenishment of ozone as it is being depleted. Second is elimination of ozone destroying agents from the atmosphere. The second method is a more permanent form of the solution. Elimination and replenishment methods are discussed in detail.

  12. Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells.

    PubMed

    Ceronie, Bryan; Jacobs, Benjamin M; Baker, David; Dubuisson, Nicolas; Mao, Zhifeng; Ammoscato, Francesca; Lock, Helen; Longhurst, Hilary J; Giovannoni, Gavin; Schmierer, Klaus

    2018-05-01

    The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-modifying treatments act by physical/functional depletion of memory B cells. A cross-sectional study examined 40 people with multiple sclerosis at the end of the first cycle of alemtuzumab or injectable cladribine. The relative proportions and absolute numbers of peripheral blood B lymphocyte subsets were measured using flow cytometry. Cell-subtype expression of genes involved in cladribine metabolism was examined from data in public repositories. Cladribine markedly depleted class-switched and unswitched memory B cells to levels comparable with alemtuzumab, but without the associated initial lymphopenia. CD3 + T cell depletion was modest. The mRNA expression of metabolism genes varied between lymphocyte subsets. A high ratio of deoxycytidine kinase to group I cytosolic 5' nucleotidase expression was present in B cells and was particularly high in mature, memory and notably germinal centre B cells, but not plasma cells. Selective B cell cytotoxicity coupled with slow repopulation kinetics results in long-term, memory B cell depletion by cladribine. These may offer a new target, possibly with potential biomarker activity, for future drug development.

  13. Using the Networked Fire Chief for ego-depletion research: measuring dynamic decision-making effort and performance.

    PubMed

    Barber, Larissa K; Smit, Brandon W

    2014-01-01

    This study replicated ego-depletion predictions from the self-control literature in a computer simulation task that requires ongoing decision-making in relation to constantly changing environmental information: the Network Fire Chief (NFC). Ego-depletion led to decreased self-regulatory effort, but not performance, on the NFC task. These effects were also buffered by task enjoyment so that individuals who enjoyed the dynamic decision-making task did not experience ego-depletion effects. These findings confirm that past ego-depletion effects on decision-making are not limited to static or isolated decision-making tasks and can be extended to dynamic, naturalistic decision-making processes more common to naturalistic settings. Furthermore, the NFC simulation provides a methodological mechanism for independently measuring effort and performance when studying ego-depletion.

  14. Large-eddy simulation of oxygen transport and depletion in waterbodies

    NASA Astrophysics Data System (ADS)

    Scalo, Carlo; Piomelli, Ugo; Boegman, Leon

    2010-11-01

    Dissolved oxygen (DO) in water plays an important role in lake and marine ecosystems. Agricultural runoff may spur excessive plant growth on the water surface; when the plants die they sink to the bottom of the water bodies and decompose, consuming oxygen. Significant environmental (and economic) damage may result from the loss of aquatic life caused by the oxygen depletion. The study of DO transport and depletion dynamics in water bodies has, therefore, become increasingly important. We study this phenomenon by large-eddy simulations performed at laboratory scale. The equations governing the transport of momentum and of a scalar (the DO) in the fluid are coupled to a biochemical model for DO depletion in the permeable sediment bed [Higashino et al., Water Res. (38) 1, 2004)], and to an equation for the fluid transpiration in the porous medium. The simulations are in good agreement with previous calculations and experiments. We show that the results are sensitive to the biochemical and fluid dynamical properties of the sediment, which are very difficult to determine experimentally.

  15. Cue-induced smoking urges deplete cigarette smokers' self-control resources.

    PubMed

    Hagger, Martin S; Leaver, Eamonn; Esser, Kerstin; Leung, Chung-Ming; Te Pas, Nina; Keatley, David A; Chan, Derwin K-C; Chatzisarantis, Nikos L D

    2013-12-01

    Exposure to smoking-related cues leads to increased urge to smoke in regular cigarette smokers and resisting these urges requires considerable self-control. Adopting a resource depletion model, two studies tested the hypothesis that resisting smoking urges depletes self-control resources. Adopting a within-participants randomized cross-over design, participants (study 1, N = 19; study 2, N = 32) were exposed to smoking-related (study 1: smoking images; study 2: cigarette cue-exposure task) and neutral (study 1: neutral images; study 2: drinking-straw task) cues with presentation order randomized. After each cue set, participants completed self-control tasks (study 1: handgrip task; study 2: handgrip and Stroop tasks), performance on which constituted dependent measures of self-control. Self-control task performance was significantly impaired when exposed to smoking-related cues compared to neutral cues. No significant presentation-order effects, or interaction effects between stimulus and presentation order, were found. Findings corroborate our hypothesis that resisting smoking urges depletes cigarette smokers' self-control resources and suggests that self-control capacity is governed by a limited resource.

  16. Reverse depletion effects and the determination of ligand density on some spherical bioparticles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Chunxiang; Liu, Yanhui, E-mail: ionazati@itp.ac.cn; Fan, Yangtao

    In cell environments crowded with macromolecules, the depletion effects act and assist in the assembly of a wide range of cellular structures, from the cytoskeleton to the chromatin loop, which are well accepted. But a recent quantum dot experiment indicated that the dimensions of the receptor–ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. In this article, a continuum elastic model is constructed to resolve the competition between the dimension of the receptor–ligand complex and depletion effects in the endocytosis of a spherical virus-like bioparticle. Our results show that the depletion effects do not alwaysmore » assist endocytosis of a spherical virus-like bioparticle; while the dimension of the ligand–receptor complex is larger than the size of a small bioparticle in cell environments, the depletion effects do not work and reverse effects appear. The ligand density covered on the virus can be identified quantitatively.« less

  17. The Water Production Rate of Comet Hale-Bopp as Determined by [O I] 6300 Angstroms Measurements

    NASA Astrophysics Data System (ADS)

    Morgenthaler, J. P.; Harris, W.; Scherb, F.; Anderson, C. W.; Roesler, F. L.; Oliversen, R. J.; Doane, N. E.; Smyth, W. H.; Marconi, M. L.

    1999-09-01

    The exceptional brightness and long observational window of Comet Hale-Bopp provided a remarkable opportunity to study both the neutral coma and the plasma in the coma and ion tail. Our team of observers from UW--Madison and Goddard Space Fight Center used seven different instruments at Kitt Peak to observe cometary emission from H, OH, O, H_2O(+) , NH_2, C, CN, C_2, and the continuum. Here we present observations and model analysis for the O((1) D) ([O I] 6300 Angstroms) emission. The data were taken by three telescopes on Kitt Peak: the Wisconsin, Indiana, Yale NRAO (WIYN), Wisconsin H-alpha Mapper (WHAM), and the NSO McMath-Pierce. The 3.5-meter WIYN telescope recorded up to 96 simultaneous spectra with a Multi-Object Spectrograph (MOS), the WHAM Fabry-Perot spectrometer recorded spectra and narrow-band images over a 1(deg) field of view and the 2-inch Fabry-Perot spectrometer at the McMath-Pierce main telescope recorded high resolution (lambda /Delta lambda = 80,000) spectra of the [O I] 6300 Angstroms emission with a 6 arcminute field of view. The combination of MOS and Fabry-Perot data covers spatial scales ranging from 2,000 km to 1x10(6) km. The high resolution spectra, recorded with a ~ 180,000 km radius field of view, show evidence of motion in the antisun direction. At distances greater than 300,000 km, we see a tailward asymmetry in the spatial distribution of [O I]. At 500,000 km, there is an excess of ~ 2x10(6) photons s(-1) cm(-2) sr(-1) (30 R) in the tailward direction. We use the data away from the tailward asymmetry and the Monte Carlo Particle Trajectory Model (MCPTM) of Combi and Smyth (1988) with recent refinements by Combi, Bos, & Smyth (1993) to estimate the water production rate of the comet in late February and early March of 1997. Preliminary results indicate water production rates of ~ 10(31) molecules/sec. Our observational and data analysis techniques along with possible sources of the asymmetry are discussed.

  18. Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis

    PubMed Central

    Wang, Ying; Cai, Kathy Qi; Smith, Elizabeth R.; Yeasky, Toni M.; Moore, Robert; Ganjei-Azar, Parvin; Klein-Szanto, Andres J.; Godwin, Andrew K.; Hamilton, Thomas C.

    2016-01-01

    We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, and epidemiological studies have established the impact of reproductive factors on ovarian cancer risk. Menopause as a result of ovarian follicle depletion is thought to contribute to higher cancer risk. As a consequence of follicle depletion, female Wv mice develop ovarian tubular adenomas, a benign epithelial tumor corresponding to surface epithelial invaginations and papillomatosis frequently found in postmenopausal human ovaries. Lineage tracing using MISR2-Cre indicated that the tubular adenomas that developed in Wv mice were largely derived from the MISR2 lineage, which marked only a fraction of ovarian surface and oviduct epithelial cells in wild-type tissues. Deletion of p27, either heterozygous or homozygous, was able to convert the benign tubular adenomas into more proliferative tumors. Restricted deletion of p53 in Wv/Wv mice by either intrabursal injection of adenoviral Cre or inclusion of the MISR2-Cre transgene also resulted in augmented tumor growth. This finding suggests that follicle depletion provides a permissive ovarian environment for oncogenic transformation of epithelial cells, presenting a mechanism for the increased ovarian cancer risk in postmenopausal women. PMID:27354067

  19. Methods for the detection and serum depletion of porcine galectin-3.

    PubMed

    Eliaz, Isaac; Patil, Aarti; Navarro-Alvarez, Nalu; Wang, Zhirui; Eliaz, Amity; Weil, Elaine; Wilk, Barry; Sachs, David H; Huang, Christene A

    2017-10-01

    Circulating galectin-3 (Gal-3) is elevated in systemic inflammatory disorders, fibrotic diseases, and in cancers. Gal-3 is a promising cancer target where it promotes tumorigenesis and metastasis, as well as in renal, pulmonary, hepatic, and cardiovascular diseases, because of its role as a driver of fibrotic remodeling. This reports goal was to establish methods for the detection and removal of porcine Gal-3 that will enable further studies of the therapeutic potential of Gal-3 depletion by apheresis in porcine disease models. The long-term aim is to develop a safe, effective method of removing Gal-3 via apheresis as a standalone therapeutic tool and as an adjuvant to other therapies. Purified recombinant porcine Gal-3 was prepared and used as the standard for development of a porcine Gal-3 enzyme-linked immunosorbent assay (ELISA). Different affinity column matrices that incorporated either a rat IgG2a anti-Gal-3 monoclonal antibody or carbohydrate ligand were assessed for depletion of Gal-3 from porcine serum. A porcine Gal-3 ELISA with a linear range from 0.3 to 20 ng/mL was able to detect native porcine Gal-3 in both fetal (∼150-200 ng/mL) and juvenile (∼5-15 ng/mL) porcine serum samples. Use of an anti-Gal-3 monoclonal antibody affinity column depleted Gal-3 from porcine serum to at least 313 pg/mL, the limit of ELISA detection. Methods have been developed for the detection and depletion of porcine Gal-3. These methods will be used to study the specific effects of Gal-3 depletion via apheresis in porcine models of disease. © 2017 Wiley Periodicals, Inc.

  20. Identifying water mass depletion in Northern Iraq observed by GRACE

    NASA Astrophysics Data System (ADS)

    Mulder, Gert; Olsthoorn, Theo; Al-Manmi, Diary; Schrama, Ernst; Smidt, Ebel

    2014-05-01

    Observations acquired by Gravity Recovery And Climate Experiment (GRACE) mission indicates a mass loss of 31±3 km3 or 130±14 mm in Northern Iraq between 2006 and 2009. This data is used as an independent validation of a hydrologic model of the region including lake mass variations. We developed a rainfall-runoff model for five tributaries of the Tigris River, based on local geology and climate conditions. Model inputs are precipitation data from Tropical Rainfall Measurement Mission (TRMM) observations, and potential evaporation from GLDAS parameters. Our model includes an extensive network of karstified aquifers that causes large natural groundwater variations in this region. Observed river discharges have been used to calibrate our model. In order to get the total mass variations, we correct for lake mass variations derived from Moderate Resolution Imaging Spectroradiometer (MODIS) data in combination with satellite altimetry and some in-situ data. Our rainfall-runoff model confirms that Northern Iraq suffered a drought between 2006 and 2009 and is consistent with the mass loss observed by GRACE in that period. Also, GRACE picks up the annual cycle predicted by the rainfall-runoff model. The total mass depletion seen by GRACE between 2006 and 2009 is 130±14 mm, which is mainly explained by a lake mass depletion of 74±4 mm and a natural groundwater depletion of approximately 50 mm. Our findings indicate that man-made groundwater extraction has a minor influence in this region while depletion of lake mass and geology play a key role.

  1. Assessing the threat that anthropogenic calcium depletion poses to forest health and productivity

    Treesearch

    Paul G. Schaberg; Eric K. Miller; Christopher Eagar

    2010-01-01

    Growing evidence from around the globe indicates that anthropogenic factors including pollution-induced acidification, associated aluminum mobility, and nitrogen saturation are disrupting natural nutrient cycles and depleting base cations from forest ecosystems. Although cation depletion can have varied and interacting influences on ecosystem function, it is the loss...

  2. ESA's Rosetta mission and the puzzles that Hale-Bopp left behind

    NASA Astrophysics Data System (ADS)

    1997-04-01

    The scientific payload was confirmed by ESA's Science Programme Committee in February. Now the scientists must perfect the full range of ultra-sensitive yet spaceworthy instruments in good time for Rosetta's despatch by an Ariane 5 launcher in January 2003. And even as most of the world was admiring Comet Hale-Bopp at its brightest, dedicated astronomers were examining the comet that will be Rosetta's target. Although too faint to be seen with the naked eye, Comet Wirtanen made its closest approach to the Sun on 14 March and a fairly close approach to the Earth on 24 March. This comet comes back every 5.5 years. Rosetta will dance attendance on Comet Wirtanen, not at the next return in 2002, nor even in 2008, but in 2013. The project is an ambitious and patient effort to achieve the most thorough investigation of a comet ever attempted. As the successor to ESA's highly successful Giotto mission to Halley's Comet and Comet Grigg-Skjellerup (which took seven years) Rosetta will spend eight years positioning itself. It will manoeuvre around the planets until it is shadowing Comet Wirtanen far beyond Mars, on nearly the same path around the Sun. In 2011 it will rendezvous with the comet and fly near it. In April 2012 Rosetta will go into a near orbit around Comet Wirtanen, and escort it for 17 busy months, as it flies in to make its closest approach to the Sun in September 2013, at the climax of the mission. "The Giotto mission placed us at the forefront of cometary exploration," comments Roger Bonnet, ESA's director of science. "The motivation came from European scientists with a sharp sense of the special importance of comets for understanding the Solar System. The same enthusiasm drives us onward to Rosetta, which will ensure our continued leadership in this important branch of space science." Scientific tasks During its prolonged operations in very close company with the comet's nucleus, Rosetta will map and examine its entire surface from distances of 10 to 50

  3. Clinical assessment of pacemaker power sources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bilitch, M.; Parsonnet, V.; Furman, S.

    1980-01-01

    The development of power sources for cardiac pacemakers has progressed from a 15-year usage of mercury-zinc batteries to widely used and accepted lithium cells. At present, there are about 6 different types of lithium cells incorporated into commercially distributed pacemakers. The authors reviewed experience over a 5-year period with 1711 mercury-zinc, 130 nuclear (P238) and 1912 lithium powered pacemakers. The lithium units have included 698 lithium-iodide, 270 lithium-silver chromate, 135 lithium-thionyl chloride, 31 lithium-lead and 353 lithium-cupric sulfide batteries. 57 of the lithium units have failed (91.2% component failure and 5.3% battery failure). 459 mercury-zinc units failed (25% component failuremore » and 68% battery depletion). The data show that lithium powered pacemaker failures are primarily component, while mercury-zinc failures are primarily battery related. It is concluded that mercury-zinc powered pulse generators are obsolete and that lithium and nuclear (P238) power sources are highly reliable over the 5 years for which data are available. 3 refs.« less

  4. Analysis of beryllium and depleted uranium: An overview of detection methods in aerosols and soils

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Camins, I.; Shinn, J.H.

    We conducted a survey of commercially available methods for analysis of beryllium and depleted uranium in aerosols and soils to find a reliable, cost-effective, and sufficiently precise method for researchers involved in environmental testing at the Yuma Proving Ground, Yuma, Arizona. Criteria used for evaluation include cost, method of analysis, specificity, sensitivity, reproducibility, applicability, and commercial availability. We found that atomic absorption spectrometry with graphite furnace meets these criteria for testing samples for beryllium. We found that this method can also be used to test samples for depleted uranium. However, atomic absorption with graphite furnace is not as sensitive amore » measurement method for depleted uranium as it is for beryllium, so we recommend that quality control of depleted uranium analysis be maintained by testing 10 of every 1000 samples by neutron activation analysis. We also evaluated 45 companies and institutions that provide analyses of beryllium and depleted uranium. 5 refs., 1 tab.« less

  5. Spontaneous Ion Depletion and Accumulation Phenomena Induced by Imbibition through Permselective Medium

    NASA Astrophysics Data System (ADS)

    Lee, Hyomin; Jung, Yeonsu; Park, Sungmin; Kim, Ho-Young; Kim, Sung Jae

    2016-11-01

    Generally, an ion depletion region near a permselective medium is induced by predominant ion flux through the medium. External electric field or hydraulic pressure has been reported as the driving forces. Among these driving forces, an imbibition through the nanoporous medium was chosen as the mechanism to spontaneously generate the ion depletion region. The water-absorbing process leads to the predominant ion flux so that the spontaneous formation of the ion depletion zone is expected even if there are no additional driving forces except for the inherent capillary action. In this presentation, we derived the analytical solutions using perturbation method and asymptotic analysis for the spontaneous phenomenon. Using the analysis, we found that there is also spontaneous accumulation regime depending on the mobility of dissolved electrolytic species. Therefore, the rigorous analysis of the spontaneous ion depletion and accumulation phenomena would provide a key perspective for the control of ion transportation in nanofluidic system such as desalinator, preconcentrator, and energy harvesting device, etc. Samsung Research Funding Center of Samsung Electronics (SRFC-MA1301-02) and BK21 plus program of Creative Research Engineer Development IT, Seoul National University.

  6. Gulf War Illnesses: Understanding of Health Effects From Depleted Uranium Evolving But Safety Training Needed

    DTIC Science & Technology

    2000-03-01

    against enemy munitions. Depleted uranium is a low- level radioactive heavy metal , and concerns have surfaced about whether exposure to it could be a...radioactive heavy metal , the potential for health effects are twofold: effects from radiation and effects from chemical toxicity. Two recent expert...depleted uranium safety training. Background Depleted uranium (DU), a low-level radioactive heavy metal , is a by- product of the process used to

  7. Systemic depletion of macrophages in the subacute phase of wound healing reduces hypertrophic scar formation.

    PubMed

    Zhu, Zhensen; Ding, Jie; Ma, Zengshuan; Iwashina, Takashi; Tredget, Edward E

    2016-07-01

    Hypertrophic scars are caused by trauma or burn injuries to the deep dermis and can cause cosmetic disfigurement and psychological issues. Studies suggest that M2-like macrophages are pro-fibrotic and contribute to hypertrophic scar formation. A previous study from our lab showed that M2 macrophages were present in developing hypertrophic scar tissues in vivo at 3-4 weeks after wounding. In this study, the effect of systemic macrophage depletion on scar formation was explored at subacute phase of wound healing. Thirty-six athymic nude mice that received human skin transplants were randomly divided into macrophage depletion group and control group. The former received intraperitoneal injections of clodronate liposomes while the controls received sterile saline injections on day 7, 10, and 13 postgrafting. Wound area, scar thickness, collagen abundance and collagen bundle structure, mast cell infiltration, myofibroblast formation, M1, and M2 macrophages together with gene expression of M1 and M2 related factors in the grafted skin were investigated at 2, 4, and 8 weeks postgrafting. The transplanted human skin from the control group developed contracted, elevated, and thickened scars while the grafted skin from the depletion group healed with significant less contraction and elevation. Significant reductions in myofibroblast number, collagen synthesis, and hypertrophic fiber morphology as well as mast cell infiltration were observed in the depletion group compared to the control group. Macrophage depletion significantly reduced M1 and M2 macrophage number in the depletion group 2 weeks postgrafting as compared to the control group. These findings suggest that systemic macrophage depletion in subacute phase of wound healing reduces scar formation, which provides evidence for the pro-fibrotic role of macrophages in fibrosis of human skin as well as insight into the potential benefits of specifically depleting M2 macrophages in vivo. © 2016 by the Wound Healing Society.

  8. Private sector embedded water risk: Merging the corn supply chain network and regional watershed depletion

    NASA Astrophysics Data System (ADS)

    Kim, T.; Brauman, K. A.; Schmitt, J.; Goodkind, A. L.; Smith, T. M.

    2016-12-01

    Water scarcity in US corn farming regions is a significant risk consideration for the ethanol and meat production sectors, which comprise 80% of all US corn demand. Water supply risk can lead to effects across the supply chain, affecting annual corn yields. The purpose of our study is to assess the water risk to the US's most corn-intensive sectors and companies by linking watershed depletion estimates with corn production, linked to downstream companies through a corn transport model. We use a water depletion index as an improved metric for seasonal water scarcity and a corn sourcing supply chain model based on economic cost minimization. Water depletion was calculated as the fraction of renewable (ground and surface) water consumption, with estimates of more than 75% depletion on an annual average basis indicating a significant water risk. We estimated company water risk as the amount of embedded corn coming from three categories of water stressed counties. The ethanol sector had 3.1% of sourced corn grown from counties that were more than 75% depleted while the beef sector had 14.0%. From a firm perspective, Tyson, JBS, Cargill, the top three US corn demanding companies, had 4.5%, 9.6%, 12.8% of their sourced corn respectively, coming from watersheds that are more than 75% depleted. These numbers are significantly higher than the global average of 2.2% of watersheds being classified as more than 75% depleted. Our model enables corn using industries to evaluate their supply chain risk of water scarcity through modeling corn sourcing and watershed depletion, providing the private sector a new method for risk estimation. Our results suggest corn dependent industries are already linked to water scarcity risk in disproportionate amounts due to the spatial heterogeneity of corn sourcing and water scarcity.

  9. STRATOSPHERIC OZONE DEPLETION: A FOCUS ON EPA'S RESEARCH

    EPA Science Inventory

    In September of 1987 the United States, along with 26 other countries, signed a landmark treaty to limit and subsequently, through revisions, phase out the production of all significant ozone depleting substances. Many researchers suspected that these chemicals, especially chl...

  10. Stress spillover in early marriage: the role of self-regulatory depletion.

    PubMed

    Buck, April A; Neff, Lisa A

    2012-10-01

    Stressful experiences external to a marriage (e.g., work stress, finances) are often associated with poor relationship functioning and lowered marital satisfaction, a phenomenon called stress spillover. To date, however, little attention has been devoted to understanding the specific mechanisms through which stress may lead to maladaptive relationship patterns. Drawing from theories of self-regulatory depletion, it was predicted that coping with external stress is an effortful process that consumes spouses' regulatory resources, leaving spouses with less energy to effectively respond to their relationship issues. The current study relied on a sample of newly married couples to examine whether self-regulatory depletion may account for the link between external stress and relationship well-being. Couples were asked to complete a 14-day daily diary that assessed their daily stress, their state of self-regulatory depletion, their marital behaviors, and their daily marital appraisals. Within-person analyses revealed that, on average, couples experienced stress spillover, such that on days when their stress was higher than usual they reported enacting more negative behaviors toward their partner and endorsed less positive appraisals of the relationship. Further analyses confirmed that self-regulatory depletion accounted for a majority of these spillover effects. These findings suggest that even happy couples may find it difficult to engage in adaptive relationship processes under conditions of stress. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  11. Modeling charge collection efficiency degradation in partially depleted GaAs photodiodes using the 1- and 2-carrier Hecht equations

    DOE PAGES

    Auden, E. C.; Vizkelethy, G.; Serkland, D. K.; ...

    2017-03-24

    Here, the Hecht equation can be used to model the nonlinear degradation of charge collection efficiency (CCE) in response to radiation-induced displacement damage in both fully and partially depleted GaAs photodiodes. CCE degradation is measured for laser-generated photocurrent as a function of fluence and bias in Al 0.3Ga 0.7As/GaAs/Al 0.25Ga 0.75As p-i-n photodiodes which have been irradiated with 12 MeV C and 7.5 MeV Si ions. CCE is observed to degrade more rapidly with fluence in partially depleted photodiodes than in fully depleted photodiodes. When the intrinsic GaAs layer is fully depleted, the 2-carrier Hecht equation describes CCE degradation asmore » photogenerated electrons and holes recombine at defect sites created by radiation damage in the depletion region. If the GaAs layer is partially depleted, CCE degradation is more appropriately modeled as the sum of the 2-carrier Hecht equation applied to electrons and holes generated within the depletion region and the 1-carrier Hecht equation applied to minority carriers that diffuse from the field-free (non-depleted) region into the depletion region. Enhanced CCE degradation is attributed to holes that recombine within the field-free region of the partially depleted intrinsic GaAs layer before they can diffuse into the depletion region.« less

  12. Modeling charge collection efficiency degradation in partially depleted GaAs photodiodes using the 1- and 2-carrier Hecht equations

    NASA Astrophysics Data System (ADS)

    Auden, E. C.; Vizkelethy, G.; Serkland, D. K.; Bossert, D. J.; Doyle, B. L.

    2017-05-01

    The Hecht equation can be used to model the nonlinear degradation of charge collection efficiency (CCE) in response to radiation-induced displacement damage in both fully and partially depleted GaAs photodiodes. CCE degradation is measured for laser-generated photocurrent as a function of fluence and bias in Al0.3Ga0.7As/GaAs/Al0.25Ga0.75As p-i-n photodiodes which have been irradiated with 12 MeV C and 7.5 MeV Si ions. CCE is observed to degrade more rapidly with fluence in partially depleted photodiodes than in fully depleted photodiodes. When the intrinsic GaAs layer is fully depleted, the 2-carrier Hecht equation describes CCE degradation as photogenerated electrons and holes recombine at defect sites created by radiation damage in the depletion region. If the GaAs layer is partially depleted, CCE degradation is more appropriately modeled as the sum of the 2-carrier Hecht equation applied to electrons and holes generated within the depletion region and the 1-carrier Hecht equation applied to minority carriers that diffuse from the field-free (non-depleted) region into the depletion region. Enhanced CCE degradation is attributed to holes that recombine within the field-free region of the partially depleted intrinsic GaAs layer before they can diffuse into the depletion region.

  13. Modeling charge collection efficiency degradation in partially depleted GaAs photodiodes using the 1- and 2-carrier Hecht equations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Auden, E. C.; Vizkelethy, G.; Serkland, D. K.

    Here, the Hecht equation can be used to model the nonlinear degradation of charge collection efficiency (CCE) in response to radiation-induced displacement damage in both fully and partially depleted GaAs photodiodes. CCE degradation is measured for laser-generated photocurrent as a function of fluence and bias in Al 0.3Ga 0.7As/GaAs/Al 0.25Ga 0.75As p-i-n photodiodes which have been irradiated with 12 MeV C and 7.5 MeV Si ions. CCE is observed to degrade more rapidly with fluence in partially depleted photodiodes than in fully depleted photodiodes. When the intrinsic GaAs layer is fully depleted, the 2-carrier Hecht equation describes CCE degradation asmore » photogenerated electrons and holes recombine at defect sites created by radiation damage in the depletion region. If the GaAs layer is partially depleted, CCE degradation is more appropriately modeled as the sum of the 2-carrier Hecht equation applied to electrons and holes generated within the depletion region and the 1-carrier Hecht equation applied to minority carriers that diffuse from the field-free (non-depleted) region into the depletion region. Enhanced CCE degradation is attributed to holes that recombine within the field-free region of the partially depleted intrinsic GaAs layer before they can diffuse into the depletion region.« less

  14. Dupoly process for treatment of depleted uranium and production of beneficial end products

    DOEpatents

    Kalb, Paul D.; Adams, Jay W.; Lageraaen, Paul R.; Cooley, Carl R.

    2000-02-29

    The present invention provides a process of encapsulating depleted uranium by forming a homogenous mixture of depleted uranium and molten virgin or recycled thermoplastic polymer into desired shapes. Separate streams of depleted uranium and virgin or recycled thermoplastic polymer are simultaneously subjected to heating and mixing conditions. The heating and mixing conditions are provided by a thermokinetic mixer, continuous mixer or an extruder and preferably by a thermokinetic mixer or continuous mixer followed by an extruder. The resulting DUPoly shapes can be molded into radiation shielding material or can be used as counter weights for use in airplanes, helicopters, ships, missiles, armor or projectiles.

  15. DUPoly process for treatment of depleted uranium and production of beneficial end products

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kalb, P.D.; Adams, J.W.; Lageraaen, P.R.

    2000-02-29

    The present invention provides a process of encapsulating depleted uranium by forming a homogeneous mixture of depleted uranium and molten virgin or recycled thermoplastic polymer into desired shapes. Separate streams of depleted uranium and virgin or recycled thermoplastic polymer are simultaneously subjected to heating and mixing conditions. The heating and mixing conditions are provided by a thermokinetic mixer, continuous mixer or an extruder and preferably by a thermokinetic mixer or continuous mixer followed by an extruder. The resulting DUPoly shapes can be molded into radiation shielding material or can be used as counter weights for use in airplanes, helicopters, ships,more » missiles, armor or projectiles.« less

  16. Antioxidant Depletion and Service Life Prediction for HDPE Geomembranes Exposed to Low-Level Radioactive Waste Leachate

    DOE PAGES

    Tian, Kuo; Benson, Craig H.; Tinjum, James M.; ...

    2017-06-01

    Antioxidant depletion was evaluated in high-density polyethylene (HDPE) geomembrane (GM) coupons immersed in radioactive synthetic leachate (RSL) representative of leachate in low-level radioactive waste (LLW) disposal facilities operated by the U.S. Department of Energy’s environmental restoration programs. Depletion was assessed at four temperatures (25, 50, 70, and 90°C). Comparative tests were conducted with nonradioactive synthetic leachate (NSL) having the same chemistry as RSL, except radionuclides were excluded. Control tests were conducted with deionized (DI) water. One-sided exposure tests were also conducted with the HDPE GM in RSL at 70 and 90°C. Specimens were removed periodically and tested to determine antioxidantmore » depletion, melt flow index (MFI), crystallinity, and stress crack resistance. Standard and high-pressure oxidative induction time (OIT) tests were conducted to measure antioxidant depletion. Antioxidant depletion rates in RSL were only slightly greater than those in NSL, indicating that radionuclides in the LLW leachate had only minor effect on antioxidant depletion. Antioxidant depletion in RSL and NSL occurred 1.1–1.9 times faster than in DI water. Antioxidant depletion in HDPE GMs exposed to RSL and NSL at 90°C was complete after 12 months. MFI decreased systematically after 15 months of immersion, which is indicative of crosslinking due to oxidation. Crystallinity also decreased slightly after 12 months, whereas stress crack resistance (SCR) showed no trend over the immersion period. Arrhenius modeling was used to extrapolate the laboratory data at elevated temperatures to a typical LLWliner at 15°C. Predicted time for antioxidant depletion for a 2-mm-thick HDPE GM in a composite liner in contact with LLW leachate is estimated to be 730 years. The total service life of HDPE GMs in contact with LLWleachate is estimated to be at least 1975 years.« less

  17. Antioxidant Depletion and Service Life Prediction for HDPE Geomembranes Exposed to Low-Level Radioactive Waste Leachate

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tian, Kuo; Benson, Craig H.; Tinjum, James M.

    Antioxidant depletion was evaluated in high-density polyethylene (HDPE) geomembrane (GM) coupons immersed in radioactive synthetic leachate (RSL) representative of leachate in low-level radioactive waste (LLW) disposal facilities operated by the U.S. Department of Energy’s environmental restoration programs. Depletion was assessed at four temperatures (25, 50, 70, and 90°C). Comparative tests were conducted with nonradioactive synthetic leachate (NSL) having the same chemistry as RSL, except radionuclides were excluded. Control tests were conducted with deionized (DI) water. One-sided exposure tests were also conducted with the HDPE GM in RSL at 70 and 90°C. Specimens were removed periodically and tested to determine antioxidantmore » depletion, melt flow index (MFI), crystallinity, and stress crack resistance. Standard and high-pressure oxidative induction time (OIT) tests were conducted to measure antioxidant depletion. Antioxidant depletion rates in RSL were only slightly greater than those in NSL, indicating that radionuclides in the LLW leachate had only minor effect on antioxidant depletion. Antioxidant depletion in RSL and NSL occurred 1.1–1.9 times faster than in DI water. Antioxidant depletion in HDPE GMs exposed to RSL and NSL at 90°C was complete after 12 months. MFI decreased systematically after 15 months of immersion, which is indicative of crosslinking due to oxidation. Crystallinity also decreased slightly after 12 months, whereas stress crack resistance (SCR) showed no trend over the immersion period. Arrhenius modeling was used to extrapolate the laboratory data at elevated temperatures to a typical LLWliner at 15°C. Predicted time for antioxidant depletion for a 2-mm-thick HDPE GM in a composite liner in contact with LLW leachate is estimated to be 730 years. The total service life of HDPE GMs in contact with LLWleachate is estimated to be at least 1975 years.« less

  18. 40 CFR Appendix F to Subpart A of... - Listing of Ozone-Depleting Chemicals

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Listing of Ozone-Depleting Chemicals F...) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. F Appendix F to Subpart A of Part 82—Listing of Ozone-Depleting Chemicals Controlled...

  19. 40 CFR Appendix F to Subpart A of... - Listing of Ozone-Depleting Chemicals

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Listing of Ozone-Depleting Chemicals F...) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. F Appendix F to Subpart A of Part 82—Listing of Ozone-Depleting Chemicals Controlled...

  20. 40 CFR Appendix F to Subpart A of... - Listing of Ozone-Depleting Chemicals

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Listing of Ozone-Depleting Chemicals F...) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. F Appendix F to Subpart A of Part 82—Listing of Ozone-Depleting Chemicals Controlled...