Participation in Education as an Invitation to Become towards the World: Hannah Arendt on the Authority, Thoughtfulness and Imagination of the Educator

ERIC Educational Resources Information Center

Veck, Wayne

2013-01-01

This article draws on Hannah Arendt's analysis of authority in education, along with her insights into the workings of the imagination and the thinking process, to argue that participation in education should be conceived as an invitation to become towards the world. The potential of this invitation, the article argues, is located in the…

For the Love of Our Children: Hannah Arendt, the Limits of Freedom and the Role of Education in a Culture of Violence

ERIC Educational Resources Information Center

Gordon, Mordechai

2015-01-01

This essay critically examines the underlying assumptions about freedom and democracy at the basis of those like the NRA who argue that the United States does not have a gun problem and that the second amendment protects citizens' rights to own any gun they wish. Inspired by Hannah Arendt's political philosophy, the author first discusses three…

Fighting without Hatred: Hannah Arendt's Agonistic Rhetoric.

ERIC Educational Resources Information Center

Roberts-Miller, Patricia

2002-01-01

Considers that Arendt's connection of argument and thinking, and her perception that both serve to thwart totalitarianism, suggest that agonal rhetoric is the best discourse for a diverse and inclusive public sphere. Notes that Arendt's advocacy of agonal rhetoric is troubling, especially in regard to its potential elitism, masculinism, and…

Hannah Arendt and the "Freedom" to Think

ERIC Educational Resources Information Center

Morgan, Marie

2016-01-01

Dissatisfied with the Western tradition of political philosophy, Arendt maintained a tension between the political, which she associates primarily with the freedom to act, and the philosophical, which she associates principally with the activity of thinking, throughout her works. Whilst Arendt's work is underpinned by a focus on political action,…

Educational Conservatism and Democratic Citizenship in Hannah Arendt

ERIC Educational Resources Information Center

Mihaila, Ramona; Popescu, Gheorghe H.; Nica, Elvira

2016-01-01

The purpose of this article was to gain a deeper understanding of Arendt's educational philosophy, her perspective of political involvement as a kind of political education, and natality as the fundamental nature of education. The current study has extended past research by elucidating Arendt's view of participatory democratic politics, her…

Hannah Arendt and the Banality of Evil.

ERIC Educational Resources Information Center

Whitfield, Stephen J.

1981-01-01

Considers Arendt's argument that Eichmann was an example of how Nazi totalitarianism changed modern concepts of evil. Concludes that an amoral bureaucracy, whose goals transcended personal judgment, involvement, or responsibility, is part of the social environment which still constitutes a threat today. (AM)

What Would Sartre Say? And, Arendt's Reply?

ERIC Educational Resources Information Center

Blau, Judith

2007-01-01

Only governments can ensure, through laws and policies, the provision of universal public goods, such as a safe supply of water, affordable health care and housing. They can regulate commerce and the private sector. However, governments cannot legislate Jean-Paul Sartre's radical freedoms, Amartya Sen's developmental freedoms, or Hannah Arendt's…

The Implications of Arendt's Concept of Judgment for Humanistic Teaching in a Postmetaphysical Age

ERIC Educational Resources Information Center

Kwak, Duck-Joo

2015-01-01

In this essay, Duck-Joo Kwak draws on Hannah Arendt's concept of judgment in exploring what it means to teach the humanities as a form of values education in a postmetaphysical age. Arendt's concept of judgment is closely related to Ciceronian humanism, which is concerned with the wisdom to choose one's company while appreciating this pursuit…

Learning to Think: Arendt on Education for Democracy.

ERIC Educational Resources Information Center

Gordon, Haim

1988-01-01

Discusses Hannah Arendt's belief that Nazi Adolf Eichmann's crimes stem from his failure to think. States that educators in a democracy must teach students to think about political and social issues. Covers methods of teaching thinking (as differentiated from problem solving) and dangers of a political realm without thinking citizens. (CH)

Educational Leadership Reconsidered: Arendt, Agamben, and Bauman

ERIC Educational Resources Information Center

Tosas, Mar Rosàs

2016-01-01

In this paper we claim educational leadership as an autonomous discipline whose goals and strategies should not mirror those typical of business and political leadership. In order to define the aims proper to educational leadership we question three common assumptions of what it is supposed to carry out. First, we turn to Hannah Arendt and her…

Reconciling Ourselves to Reality: Arendt, Education and the Challenge of Being at Home in the World

ERIC Educational Resources Information Center

Biesta, Gert

2016-01-01

In this paper, I explore the educational significance of the work of Hannah Arendt through reflections on four papers that constitute this special issue. I focus on the challenge of reconciling ourselves to reality, that is, of being at home in the world. Although Arendt's idea of being at home in the world is connected to her explorations of…

Hannah Arendt, Education, and the Question of Totalitarianism

ERIC Educational Resources Information Center

Spector, Hannah

2016-01-01

The aim of this paper is to consider the ways in which Arendt's writings on totalitarianism act as a warning sign for political and miseducational circumstances in the USA. Because the term totalitarianism has been used imprudently (largely in the mass media) to express repressive conditions in so-called models of democracy, this paper seeks to…

Images, Dialogue, and Aesthetic Education: Arendt's Response to the Little Rock Crisis

ERIC Educational Resources Information Center

Pickett, Adrienne

2009-01-01

On September 4, 1957, a crisis occurred at Little Rock Central High School in which a mob of white citizens followed, taunted, and harassed a black student, Elizabeth Eckford, who was attempting to register for classes at the newly desegregated school. In 1959, Hannah Arendt published "Reflections on Little Rock." She argued that…

Education as Action/The Adventure of Education: Thinking with Arendt and Whitehead

ERIC Educational Resources Information Center

Tamboukou, Maria

2016-01-01

Understanding and action are central themes in Hannah Arendt's thought and an idea that runs throughout her work is that whenever human beings act, they start processes. It is in this light that she saw education as a process whose aim is to make human beings feel at home in the world. Given the centrality of process in understanding action, early…

Winnicott and Arendt: bridging potential and political spaces.

PubMed

LaMothe, Ryan

2014-04-01

In this article, the author seeks to bridge analytic theory, which is used as an interpretive framework to understand patients' psychic lives, and political philosophy, which accounts for individuals living a life in common as citizens. Specifically, I address how we can understand the relation between the psychosocial space of a parent(s) and child interaction, which becomes part of the child's psychic life, and the political space between and within citizens. The underlying claim is that there is a correlation between political space and the space between parent and child. I use an emended version of Donald Winnicott's concept of potential space and political philosopher Hannah Arendt's notion of the space of appearances to suggest connections between the consulting room and political space.

The Soviet Theory of Reflexive Control in Historical and Psychocultural Perspective: A Preliminary Study

DTIC Science & Technology

1986-07-01

broad spectrum of military and political affairs. After all, historian Hannah Arendt ,153 economist John Kenneth Galbraith,154 and sociologists Raven and...Military Systems Engineering (op. cit.), pp. 334-348. 153 Arendt , Hannah , The Origins of Totalitarianism, Harcourt Brace and Company, New York, 1951...and Crisis Behavior, George Allen and Unwin, London, 198Z. Arendt , Hannah , The Origins of Totalitarianism, Harcourt Brace and Company, New York, 1951

Measuring Success in Populace and Resources Control

DTIC Science & Technology

1967-05-29

dealt with if democracy is to survive. Military strategists should take notice of the warning of the noted political scientist, Hannah Arendt , who...revolutionary conflict: a Harold K. Johnson, "Landpower Missions Unlimited," Army, XV (November, 1964), 41-42. 2 Hannah Arendt , On Revolution (New...Government Printing Office, 1963. Books Arendt , Hannah . On Revolution. New York: Viking Press, 1963. Baclagon, Uldanico S. Lessons Prom the Huk Campaign

Asking the Right Questions: A Framework for Assessing Counterterrorism Actions

DTIC Science & Technology

2016-02-01

into obedience. Hannah Arendt , “Ideology and Terror: A Novel Form of Government,” The Review of Politics 15, no. 3 (July 1953). 20 Policymakers...Summer 1974): 291. See also Hannah Arendt , On Violence (New York: Harcourt, Brace & World, 1969), p. 89. 32 Max Abrams, “What Terrorists Really...Operation Assessment, August 2015. Arendt , Hannah , “Ideology and Terror: A Novel Form of Government,” The Review of Politics, 15, no. 3 (July 1953

On Political War

DTIC Science & Technology

1989-12-01

LENINISM It has been argued-perhaps most cogently by Hannah Arendt - that Nazi Germany and Stalinist Russia were both forms of totalitarianism; that both...state system. "The way w., prepared," Hannah Arendt later observed, "by fifty years of the rise of imperialism and disintegration of the nation-state...propaganda and disinformation operations against Britain, and of Britain’s erratic efforts to assess and counter them. Arendt , Hannah . The Origins of

Hannah Miller | NREL

Science.gov Websites

Hannah Miller desc Hannah Miller Group Administrative Assistant Hannah.Miller@nrel.gov | 303-275 -3671 Hannah Miller is staff support for the Applied Engineering and Modeling Group in the Integrated Applications Center. Hannah is a former office manager, communications director, and sales consultant for

The Moral Dimension of Strategy

DTIC Science & Technology

1977-01-01

conflict is no longer a purely governmental affair. The late Hannah Arendt , perhaps the best kn own western student of revolution, criticized-in an...encounters fomented great debates within our society during and after their prosecu lion. Hannah Arendt believed that "the end of war is revolution...4. Frankel, p. 36. 5. Niebuhr, p. 96. 6. Hannah Arendt , On Revolution (New York: The Viking Press, 1965), p. 8. 7. Robert G. Gard, Jr., "The

On Disarmament: The Role of Conventional Arms Control in National Security Strategy

DTIC Science & Technology

1990-03-01

both have their stable and predetermined place." Furthermore, Hannah Arendt insists that "since authority always demands obedience, it is commonly...Its Critics, ed. by Robert 0. Keohane, New York: Columbia University Press, 1986, p. 137. 5. Hannah Arendt , "What Is Authority?" in Between Past and...Talks." Defense News, February 13,1989, p. A3. Allison, Graham. "Success is Within Reach." The New York Times, February 19,1989, p. E19. Arendt , Hannah

An Annotated Bibliography of the Open Literature on Deception.

DTIC Science & Technology

1985-12-01

Potter, 1961, pp. 82, 102-103; ch. 8, "For Righteous or Sinners,", pp. 87-104. Arendt , Hannah , "Lying in Politics: Reflections on the Pentagon Papers...79 Ardamatskiy, Vasiliy Ivanovich............................. 103 Arendt , Hannah ...34 New York Review of Books, Vol. 17, No. 8, November 18, 1971, pp. 30-39; in H. Arendt , Lying in Politics. New York- Harcourt, Brace, Jovanovich

Non-Offensive Defense and Nonviolence Response to Terrorism

DTIC Science & Technology

2008-04-03

other words, the means are the ends. Political philosopher Hannah Arendt similarly concludes, “Since the end of human action…can never be reliably...Terrorism. (Boulder: Paradigm Publishers, 2006), 18. 34Ibid. 35Hannah Arendt , On Violence (New York: Harcourt Brace, 1970), 4. 36Walter Wink, The Powers

Exploring the critiques of the social model of disability: the transformative possibility of Arendt's notion of power.

PubMed

Owens, Janine

2015-03-01

The social model of disability has demonstrated political success for disabled people in society. At the same time, it has been labelled an outdated ideology in need of further development. While the social model of disability has been used successfully for political activism, it has simultaneously created conflict and tensions in disability studies, sociology and the sociology of the body. This article sheds light on the confusion surrounding the social model of disability by discussing the historical emergence of its different forms. It then proceeds to analyse and evaluate key criticisms of the social model of disability. The article then goes on to explore the relevance of different forms of power to the current discourse on disability before proceeding to explore in depth what might be gained from the approach of one particular theorist on power; Hannah Arendt. It suggests that there may be merit in drawing on Arendt and illustrates some of the benefits of a more nuanced idea of a pluralistic body and experiences. © 2014 Foundation for the Sociology of Health & Illness.

NATO: Maintaining Relevance in the Twenty-First Century

DTIC Science & Technology

2012-06-01

NATO Secretary General. “NATO after Lybia.” Foreign Affairs (July/August 2011): 1–3. Arendt , Hannah . On Violence. Orlando, FL: Harcourt Books...2003. http://eur- lex.europa.eu/JOHtml.do?uri=OJ:L:2003:143:SOM:EN:HTML (accessed February 1, 2011). d’ Entreves, Maurizio Passerin. Hannah Arendt ...Stanford Encylcopedia of Philosophy). July 27, 2006. http://plato.stanford.edu/entries/ arendt / (accessed June 5, 2011). 66 Faria, Fernanda. “EUISS

Obedience In Perspective: Psychology and the Holocaust

DTIC Science & Technology

2015-01-01

Arendt , Hannah (1963). Eichmann in Jerusalem. London: Faber and Faber. Bartov, Omer. (2001). The Eastern Front, 1941-1945: German Troops and the...Nuremberg Tribunals following the defeat of Germany in World War II and the trial of Adolf Eichmann in Jerusalem in 1961 ( Arendt , 1963). Second...separated from the rest of us. After Hannah Arendt’s interpretation of Eichmann and the Milgram experiments, though, it seemed clear that absolutely

Image of the Wehrmacht in Federal German Society and in the Tradition of the Bundeswehr

DTIC Science & Technology

1999-08-01

politicians in 33 Hans-Peter Schwarz, Die Aera Adenauer, 1957-1963, pp.204-216; Hannah Arendt , Eichmann in...became unhinged by the behavior of the man in the glass booth. Hannah Arendt’s thesis of the banality of evil when applied to Eichmann’s biography

The Law of Force or The Force of Law: Does Following The Rule of Law Assist Security Forces in Defeating an Armed Insurgency?

DTIC Science & Technology

2012-06-08

and Policy in International Relations (Spring): 40-79 Arendt , Hannah . 1963. On revolution. New York: Viking Cohen, Eliot A., John Horvath, and...conditions, where the armed forces can be trusted to obey the civil authorities” ( Arendt 1965, 40). This is especially the case in countries where

Psychological Approaches to Organized Agression

DTIC Science & Technology

1987-01-01

have in time become respected political figures and even acknowledged statesmen. One does not have to accept Hannah Arendt’s (1979) notion of the so... Arendt , H. - Eichmann in Jerusalem, New York, St. Martin’s Press, 1979. Aston, C. - A contemporary crisis: Political hostage-taking, London, Greenwood

NATO Enlargement and Democratic Control of the Armed Forces: The Experience of Poland and Implications for Neighboring "Partnership for Peace" Countries.

DTIC Science & Technology

1998-03-01

borders. You do not follow our suggestions, and we feel threatened...we are 88 See Hannah Arendt , "Reflections on the Hungarian Revolution," Journal of...Press, 1977). Arendt , Hanna, "Reflections on the Hungarian Revolution," Journal of Politics 20.1 (February 1958). Bebler, Anton A., "Postscript" in

Schools as Architecture for Newcomers and Strangers: The Perfect School as Public School?

ERIC Educational Resources Information Center

Masschelein, Jan; Simons, Maarten

2010-01-01

Background/Context: The article reflects on the public role of education on the occasion of the 50th anniversary of the publication of Hannah Arendt's essay, "The Crisis in Education" and in facing the current transformation of public policy into "new public management." Purpose/Objective/Research Question/Focus of Study: Based on Arendt's essay,…

Thinking-in-Concert

ERIC Educational Resources Information Center

O'Donnell, Aislinn

2012-01-01

In this essay, I examine the concept of thinking in Hannah Arendt's writings. Arendt's interest in the experience of thinking allowed her to develop a concept of thinking that is distinct from other forms of mental activity such as cognition and problem solving. For her, thinking is an unending, unpredictable and destructive activity without fixed…

Military History of the American Revolution. Proceedings of the Military History Symposium (6th) Held at the Air Force Academy, Colo. on 10-11 October 1974,

DTIC Science & Technology

1976-01-01

heartedly planned a coup d’etat to get :he money owed them by Congress.2 6 The Revolution, as; an armed struggle, ended with a whimper. " Hannah Arendt , Ott...HWashington, X, 54-56, 332; David Uriffith to Mrs Hannah Griffith, November 13, 1777, David Griffith Papers. Virginia Historical Society; George Weedon to

Cultivating the Ethical Imagination in Education: Perspectives from Three Public Intellectuals

ERIC Educational Resources Information Center

Spector, Hannah

2017-01-01

Because the subject of imagination is both complex and can be conceived of in different ways, the focus of the first part of this article is to engage in a descriptive analysis of this faculty. With the help of Greene's intellectual predecessor and former teacher Hannah Arendt, Hannah Spector draws distinctions between imagination and other…

"On Behalf of a Shared World": Arendtian Politics in a Culture of Youth Media Participation

ERIC Educational Resources Information Center

Poyntz, Stuart R.

2009-01-01

More than 30 years since Hannah Arendt's death in 1975 at the age of 69, her novel theory of the public realm continues to attract attention and debate. In this article, the author contributes to this discussion by drawing on Arendt's theory of public life to investigate the space of youth media production in relation to questions of democratic…

Action in a Shared World

ERIC Educational Resources Information Center

Hinchliffe, Geoffrey

2010-01-01

Background/Context: The background of the article is the continued interest in the ideas of Hannah Arendt. In her book The Human Condition, Arendt draws on sources of ideas drawn from Ancient Greece to deliver a critique of modernity. The main burden of her criticism is that the imperatives of work and labor have virtually supplanted the ideal of…

Toward a Cosmopolitan Curriculum of Forgiveness

ERIC Educational Resources Information Center

Kennedy, R. M.

2011-01-01

Hannah Arendt articulates natality as the very "essence of education." Natality expresses the unique capacity of each person to bring about something new in relation to an inherited world. Education's difficult work, in Arendt's view, is not only to introduce students to the truths of the world as it is, but also to nurture the capacity to make…

The Literature of Low Intensity Conflict: A Selected Bibliography and Suggestions for Future Research (CLIC Papers)

DTIC Science & Technology

1988-09-01

Alnwick, Kenneth J. "Perspectives on Air Power At the Low End of the Conflict Spectrum." Air University Review 35 (March- April 1984). Arendt , Hannah . On...HUNTINGTON on the cause of disorder in developing nations, ARENDT on the philosophy of revolution, CHALMERS JOHNSON on the general theory of revolution... Arendt , 2, 7 Doctrine, 1, 3, 4, 6, 8, 9, 10, Arnold, 14 13, 14, 16, 17, 18, 19, 20 Asprey, 3, 7 Dodd, 10 Atkinson, 1, 7 Dubik, 3, 10 Barber, 2, 7 Dunn, 2

The Evil of Banality: Arendt Revisited

ERIC Educational Resources Information Center

Minnich, Elizabeth

2014-01-01

"The banality of evil" (Arendt) remains controversial and useful. Ironically, the concept is now itself a banality. To revisit and extend it, we consider the "evil of banality", the profound dangers of cliched thoughtlessness. A distinction is proposed: "intensive" versus "extensive evils". The former takes…

Agonistic Recognition in Education: On Arendt's Qualification of Political and Moral Meaning

ERIC Educational Resources Information Center

Ljunggren, Carsten

2010-01-01

Agonistic recognition in education has three interlinked modes of aesthetic experience and self-presentation where one is related to actions in the public realm; one is related to plurality in the way in which it comes into existence in confrontation with others; and one is related to the subject-self, disclosed by "thinking. Arendt"s conception…

Educational Leadership with an Ethics of Plurality and Natality

ERIC Educational Resources Information Center

Berger, Iris

2015-01-01

This paper aims to impregnate the concept of educational leadership with new meanings and new possibilities. I draw on Hannah Arendt's ("The human condition." University of Chicago Press, Chicago, 1958/1998) political thought, particularly, her concepts of "plurality" and "natality" alongside the distinction she made…

Arctic Ice Melting: National Security Implications

DTIC Science & Technology

2011-02-01

be a curse rather than a good, and under no conditions can it either lead into freedom or constitute a proof for its existence. - Hannah ... Arendt 39 How will the domestic or foreign economic policies of the United States be affected by Arctic ice melting? Increased access to the

Writing Together: An Arendtian Framework for Collaboration

ERIC Educational Resources Information Center

Restaino, Jessica

2014-01-01

This essay considers the long-standing challenges, in both practice and theory, to collaborative writing in the first-year classroom. I argue that Hannah Arendt's concepts of plurality and natality are useful frameworks for thinking constructively and practically about teaching argumentative writing through collaboration. I explore these…

"Plays Well with Others": The Engagement of Philosophy of Education with Other Educational Research

ERIC Educational Resources Information Center

Ruitenberg, Claudia

2014-01-01

This essay takes up John White's argument for an engagement and collaboration of philosophy of education with other disciplines, and in particular with other forms of educational research. It examines the benefits and risks of "situated" or "embedded" philosophy as well as Hannah Arendt's claims about the separation of…

Brecht: A Collection of Critical Essays. Twentieth Century Views Series.

ERIC Educational Resources Information Center

Demetz, Peter, Ed.

One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Sergey Tretiakov, Hearings of the House Committee on Un-American Activities, Hannah Arendt, Eric Bentley, Oscar Budel, Ernst Schumacher, I. Fradkin, Hans Egon Holthusen, Gunter Rohrmoser, Walter H. Sokol, Franz Norbert…

On Practising in Physical Education: Outline for a Pedagogical Model

ERIC Educational Resources Information Center

Aggerholm, K.; Standal, O.; Barker, D. M.; Larsson, H.

2018-01-01

Background: Models-based approaches to physical education have in recent years developed as a way for teachers and students to concentrate on a manageable number of learning objectives, and align pedagogical approaches with learning subject matter and context. This paper draws on Hannah Arendt's account of "vita activa" to map existing…

The Turn to Experience in Contemporary Art: A Potentiality for Thinking Art Education Differently

ERIC Educational Resources Information Center

O'Donoghue, Dónal

2015-01-01

This article considers the turn to experience in contemporary art and examines its potentiality for thinking art education differently. This project should not be mistaken for what Hannah Arendt (1968) identified as "the extraordinary enthusiasm for what is new" (p. 176). Rather, its purpose is to pursue another possibility for art…

The Politics of Storytelling: Unfolding the Multiple Layers of Politics in (P)AR Publications

ERIC Educational Resources Information Center

Santos, Doris

2012-01-01

In the social sciences, inquiry into the relationship between storytelling and politics is based on a notion of historical continuity. One problem is the possible trap of inevitability inherent in this notion--that something which happened "had to happen". Hannah Arendt's conception of political theory as storytelling overcomes this trap,…

"I'm Not so Sure…": Teacher Educator Action Research into Uncertainty

ERIC Educational Resources Information Center

Rogers, Carrie

2016-01-01

Using a framework of uncertainty that is informed by Hannah Arendt's philosophy this four-semester action research project describes the creation and analysis of an assignment that allows teacher candidates to explore their own uncertainties in regards to the teaching profession. This action research project examines the assignment and its…

Hemostatic interference of Indian king cobra (Ophiophagus hannah) Venom. Comparison with three other snake venoms of the subcontinent.

PubMed

Gowtham, Yashonandana J; Kumar, M S; Girish, K S; Kemparaju, K

2012-06-01

Unlike Naja naja, Bungarus caeruleus, Echis carinatus, and Daboia/Vipera russellii venoms, Ophiophagus hannah venom is medically ignored in the Indian subcontinent. Being the biggest poisonous snake, O. hannah has been presumed to inject several lethal doses of venom in a single bite. Lack of therapeutic antivenom to O. hannah bite in India makes any attempt to save the victim a difficult exercise. This study was initiated to compare O. hannah venom with the above said venoms for possible interference in hemostasis. Ophiophagus hannah venom was found to actively interfere in hemostatic stages such as fibrin clot formation, platelet activation/aggregation, and fibrin clot dissolution. It decreased partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin clotting time (TCT). These activities are similar to that shown by E. carinatus and D. russellii venoms, and thus O. hannah venom was found to exert procoagulant activity through the common pathway of blood coagulation, while N. naja venom increased aPTT and TCT but not PT, and hence it was found to exert anticoagulant activity through the intrinsic pathway. Venoms of O. hannah, E. carinatus, and D. russellii lack plasminogen activation property as they do not hydrolyze azocasein, while they all show plasmin-like activity by degrading the fibrin clot. Although N. naja venom did not degrade azocasein, unlike other venoms, it showed feeble plasmin-like activity on fibrin clot. Venom of E. carinatus induced clotting of human platelet rich plasma (PRP), while the other three venoms interfered in agonist-induced platelet aggregation in PRP. Venom of O. hannah least inhibited the ADP induced platelet aggregation as compared to D. russellii and N. naja venoms. All these three venoms showed complete inhibition of epinephrine-induced aggregation at varied doses. However, O. hannah venom was unique in inhibiting thrombin induced aggregation.

Action, an "Encompassing Ethic" and Academics in the Midst of the Climate Crisis

ERIC Educational Resources Information Center

Plowright, Susan

2016-01-01

In the midst of a crisis like the climate crisis and calls for "all hands on deck", what do academics, as a microcosm of humanity, see? In Hannah Arendt's terms, an "abyss of freedom" to act or a paralysing "abyss of nothingness"? Some from the academy themselves, including Tamboukou, Apple and Bourdieu, make…

Touched by Injury: Toward an Educational Theory of Anti-Racist Humanism

ERIC Educational Resources Information Center

Georgis, Dina; Kennedy, R. M.

2009-01-01

Informed by the critical humanisms of Hannah Arendt, Frantz Fanon, and Paul Gilroy, the authors argue for an orientation to teaching and learning that troubles the continuing effects of dehumanizing race logic. Reflecting on Paul Haggis's Oscar award winning film "Crash" from 2004, they suggest that the metaphor of racial "crashing" captures what…

Educational Thinking and the Conservation of the Revolutionary

ERIC Educational Resources Information Center

Duarte, Eduardo Manuel

2010-01-01

Background/Context: Prior work on Hannah Arendt and education has focused on democratic education, multicultural education, and conservatism in education. Most of these studies have concentrated on her essay, "The Crisis in Education." While this study extends that work, it does so by taking up the lesser studied but equally relevant piece,…

Challenging Age Power Structures: Creating a Public Sphere in Preschool through "Musicking"

ERIC Educational Resources Information Center

Wassrin, Maria

2016-01-01

This article explores the possibility of conceiving preschool music activities as a way of forming spaces of participation with society's youngest. The discussion draws on Hannah Arendt's ([1958] 1998) definition of public spheres, and the argumentation is closely linked to an empirical example from musicking events with 1-3 year olds in a…

The Politics of the Academies Programme: Natality and Pluralism in Education Policy-Making

ERIC Educational Resources Information Center

Gunter, Helen M.; McGinity, Ruth

2014-01-01

Our investigations into the politics of the Academies Programme in England have generated thinking that draws on data about the conversion process from two projects. We engage with an early City Academy that replaced two "failing" schools, and a recent Academy that replaced a "successful" high school. We deploy Hannah Arendt's…

Political Participation as Public Pedagogy--The Educational Situation in Young People's Political Conversations in Social Media

ERIC Educational Resources Information Center

Andersson, Erik; Olson, Maria

2014-01-01

In this article we argue that young people's political participation in the social media can be considered "public pedagogy". The argument builds on a previous empirical analysis of a Swedish net community called Black Heart. Theoretically, the article is based on a particular notion of public pedagogy, education and Hannah Arendt's…

Social Networking and Democratic Practices as Spheres for Innovative Musical Learning

ERIC Educational Resources Information Center

Thorgersen, Cecilia Ferm; Georgii-Hemming, Eva

2012-01-01

This chapter takes into account and discusses innovative learning in the 21st digital and communicative century based on life-world-phenomenology and Hannah Arendt's view of democracy. From this point of view, the authors address and discuss how democratic practices can offer innovative musical learning in relation to what is taking place in…

Children's Participation: An Arendtian Criticism

ERIC Educational Resources Information Center

Jessop, Sharon

2011-01-01

Hannah Arendt's critique of education in 1950s USA provides an important way of understanding the development of citizenship education. Her theory on the nature of childhood and her concepts of natality and authority give insight into both the directions of current policies and practices, and the possible future states into which these elements…

Remaking Public Spaces for Civil Society

ERIC Educational Resources Information Center

Ranson, Stewart

2012-01-01

The collective action predicaments of the time require citizens to participate in remaking the governance of civil society so that they can become engaged and cooperate together. Can citizens become makers of civil society? This article draws upon Hannah Arendt's "On Revolution" to provide a theory of remaking in which citizens come together to…

Sexuality and Violence.

ERIC Educational Resources Information Center

Sanctuary, Gerald

The author examines specific manifestations of violence in relation to sexuality: (1) forcible rape rate; (2) war atrocities; (3) sexual violence in prisons; and (4) pornography. Drawing much from Hannah Arendt's book on violence, he views sexual violence as symptomatic of a lack of sexual power, not a sign of its possession. The causes are seen…

Knowledge Activism: Bridging the Research/Policy Divide

ERIC Educational Resources Information Center

Gillies, Donald

2014-01-01

How research can better inform policy and how policy can have a better research base are longstanding issues both in educational research and across public policy generally. Drawing on the work of Hannah Arendt, this article argues that progress in increasing the impact of research can be made through a clearer understanding of the nature of…

Experimentum Scholae: The World Once More...But Not (Yet) Finished

ERIC Educational Resources Information Center

Masschelein, Jan

2011-01-01

Inspired by Hannah Arendt, this contribution offers an exercise of thought as an attempt to distil anew the original spirit of what education means. It tries to articulate the event or happening that the word names, the experiences in which this happening manifests itself and the (material) forms that constitute it or make it find/take (its)…

Drawing and Storytelling as Political Action: Difference, Plurality and Coming into Presence in the Early Childhood Classroom

ERIC Educational Resources Information Center

Sunday, Kristine E.

2018-01-01

This article is an embodied representation of how narrative illustrates Hannah Arendt's ideas of action, natality and plurality. It is, in essence, a story of a story that situates the actions of two young children as an instance where difference came together through the political and public act of drawing. Throughout the unfolding of the event,…

Children in Public or "Public Children": An Alternative to Constructing One's Own Life

ERIC Educational Resources Information Center

Vansieleghem, Nancy

2009-01-01

This article arises from the thoughts of Hannah Arendt, and more especially from her idea that the essence of education is the renewal of the world. That idea forms the backdrop to a consideration of the current interest in education as the construction of one's own life. I argue that the will to construct one's own life is not a natural,…

Ophiophagus hannah venom: proteome, components bound by Naja kaouthia antivenin and neutralization by N. kaouthia neurotoxin-specific human ScFv.

PubMed

Danpaiboon, Witchuda; Reamtong, Onrapak; Sookrung, Nitat; Seesuay, Watee; Sakolvaree, Yuwaporn; Thanongsaksrikul, Jeeraphong; Dong-din-on, Fonthip; Srimanote, Potjanee; Thueng-in, Kanyarat; Chaicumpa, Wanpen

2014-05-13

Venomous snakebites are an important health problem in tropical and subtropical countries. King cobra (Ophiophagus hannah) is the largest venomous snake found in South and Southeast Asia. In this study, the O. hannah venom proteome and the venom components cross-reactive to N. kaouthia monospecific antivenin were studied. O. hannah venom consisted of 14 different protein families, including three finger toxins, phospholipases, cysteine-rich secretory proteins, cobra venom factor, muscarinic toxin, L-amino acid oxidase, hypothetical proteins, low cysteine protein, phosphodiesterase, proteases, vespryn toxin, Kunitz, growth factor activators and others (coagulation factor, endonuclease, 5'-nucleotidase). N. kaouthia antivenin recognized several functionally different O. hannah venom proteins and mediated paratherapeutic efficacy by rescuing the O. hannah envenomed mice from lethality. An engineered human ScFv specific to N. kaouthia long neurotoxin (NkLN-HuScFv) cross-neutralized the O. hannah venom and extricated the O. hannah envenomed mice from death in a dose escalation manner. Homology modeling and molecular docking revealed that NkLN-HuScFv interacted with residues in loops 2 and 3 of the neurotoxins of both snake species, which are important for neuronal acetylcholine receptor binding. The data of this study are useful for snakebite treatment when and where the polyspecific antivenin is not available. Because the supply of horse-derived antivenin is limited and the preparation may cause some adverse effects in recipients, a cocktail of recombinant human ScFvs for various toxic venom components shared by different venomous snakes, exemplified by the in vitro produced NkLN-HuScFv in this study, should contribute to a possible future route for an improved alternative to the antivenins.

A petition to Mr Peel: Gideon Mantell and the trial of Hannah Russell.

PubMed

Flanagan, R J; Watson, K D

2009-07-01

In the summer of 1826, Hannah Russell was tried for petty treason, viz. the murder of her husband, Benjamin Russell, by poisoning. Their lodger, Daniel Leney, was indicted as her accomplice. The exact circumstances surrounding the death were unclear but Hannah was known to have purchased white arsenic (arsenious oxide). A local surgeon, Thomas Evans, supported at the post-mortem examination by two further surgeons, not only reported severe corrosion of the gastrointestinal tract, but also the recovery of nearly an eighth of an ounce of arsenic from the victim's stomach. Both accused were convicted and sentenced to death. Leney was executed, but Hannah Russell was respited because the trial judge, Sir Robert Graham, had doubts as to a direction he had given to the jury. The surgeon and paleontologist Gideon Mantell took up her case, stressing that death from arsenic could not have taken place as quickly as was alleged and maintaining that the chemical evidence of arsenic poisoning was inconclusive. He gained the support of some eminent chemists and physicians. Subsequently, forensic toxicologists [Sir] Robert Christison and Alfred Swaine Taylor pointed out that Mantell's arguments as to the possible time to death in arsenic poisoning were quite wrong. Moreover, Evans gave details of the analyses he and his colleagues had undertaken to Christison, who pronounced the findings sound, as indeed did Mantell after Evans and his colleagues published details of their investigations in the Sussex Advertiser. Papers in The National Archives show that Hannah was pardoned for the offence for which she was indicted, leaving it open to prefer a lesser charge. That this was never done may have been due to Mantell's campaign, at least in part, but the pardon she did receive was due to the concern of the trial judge as to the implications of the evidence presented at trial.

The social worker as moral citizen: ethics in action.

PubMed

Manning, S S

1997-05-01

Social workers today face some of the most complex ethical dilemmas in the history of the profession. This article presents a framework of moral citizenship to guide ethical social work practice. The framework includes the action philosophies of philosopher Hannah Arendt and Lutheran theologian Paul Tillich integrated with concepts of professional responsibility and the unique contributions of social work pioneer Charlotte Towle. Social conscience and social consciousness, including awareness, thinking, feeling, and action, are major components of the framework.

Ethically Important Moments in the Higher Education Space of Appearance: Renewing Educative Praxis with Arendt

ERIC Educational Resources Information Center

Taylor, Carol A.

2017-01-01

This article proposes a novel theorisation of higher education classroom spaces by bringing Arendt's concept of the space of appearance into relation with Guillemin and Gillam's notion of ethically important moments. The main arguments are first, that a focus on ethically important moments within the higher education space of appearance enables a…

Epilepsy postings on YouTube: exercising individuals' and organizations' right to appear.

PubMed

Kerson, Toba Schwaber

2012-01-01

Philosopher Hannah Arendt maintains that everyone has the right to appear in public as an embodied, singular individual. Because of the stigma attached to epilepsy, many with this condition are denied this right. Using grounded theory techniques, the author analyzes uploads of epilepsy on YouTube. The author argues that personal uploads on YouTube are the only mass media examples in which those with epilepsy can exercise their right to appear without the interpretation of intermediaries. Emerging themes relating to "the right to appear" allow social workers to deepen understanding of this and other devastating, often invisible and sometimes life-threatening illnesses.

The "Civic-Minded" Professional? An Exploration through Hannah Arendt's "Vita Activa"

ERIC Educational Resources Information Center

Kreber, Carolin

2016-01-01

Recent reform initiatives calling for "civic" ("public-good" or "democratic") professionalism can be seen as a response to the widely reported decline in public trust in the professions and an attempt to partially remedy this problem through a more publically engaged professionalism. The author draws on the political…

[Public and private in times of the pest].

PubMed

Caponi, S

1999-01-01

The paper explores how Hannah Arendt's oppositions public-private and intimate-social can be used as an analytical tool to better understand a very concrete, extreme situation: the state of emergency triggered when an epidemiological outbreak hits a city, totally altering its inhabitants lives. Studied observation of what specific individuals (be they imagined or real) feel and think during times of epidemic is an underutilized tool that may prove helpful in studying epidemics themselves. Focusing on Camus' "The pest" and events in the city of Oran, the article looks at how victims of the plague felt about their public or private lives and their intimate and social ties.

Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah).

PubMed

Tan, Choo Hock; Tan, Kae Yi; Fung, Shin Yee; Tan, Nget Hong

2015-09-10

The king cobra (Ophiophagus hannah) is widely distributed throughout many parts of Asia. This study aims to investigate the complexity of Malaysian Ophiophagus hannah (MOh) venom for a better understanding of king cobra venom variation and its envenoming pathophysiology. The venom gland transcriptome was investigated using the Illumina HiSeq™ platform, while the venom proteome was profiled by 1D-SDS-PAGE-nano-ESI-LCMS/MS. Transcriptomic results reveal high redundancy of toxin transcripts (3357.36 FPKM/transcript) despite small cluster numbers, implying gene duplication and diversification within restricted protein families. Among the 23 toxin families identified, three-finger toxins (3FTxs) and snake-venom metalloproteases (SVMPs) have the most diverse isoforms. These 2 toxin families are also the most abundantly transcribed, followed in descending order by phospholipases A2 (PLA2s), cysteine-rich secretory proteins (CRISPs), Kunitz-type inhibitors (KUNs), and L-amino acid oxidases (LAAOs). Seventeen toxin families exhibited low mRNA expression, including hyaluronidase, DPP-IV and 5'-nucleotidase that were not previously reported in the venom-gland transcriptome of a Balinese O. hannah. On the other hand, the MOh proteome includes 3FTxs, the most abundantly expressed proteins in the venom (43 % toxin sbundance). Within this toxin family, there are 6 long-chain, 5 short-chain and 2 non-conventional 3FTx. Neurotoxins comprise the major 3FTxs in the MOh venom, consistent with rapid neuromuscular paralysis reported in systemic envenoming. The presence of toxic enzymes such as LAAOs, SVMPs and PLA2 would explain tissue inflammation and necrotising destruction in local envenoming. Dissimilarities in the subtypes and sequences between the neurotoxins of MOh and Naja kaouthia (monocled cobra) are in agreement with the poor cross-neutralization activity of N. kaouthia antivenom used against MOh venom. Besides, the presence of cobra venom factor, nerve growth factors

Identification and evaluation of agents isolated from traditionally used herbs against Ophiophagus hannah venom.

PubMed

Salama, R; Sattayasai, J; Gande, A K; Sattayasai, N; Davis, M; Lattmann, E

2012-02-01

The aim of this study was firstly to identify active molecules in herbs, that are traditionally used for the treatment of snake bite, such as Curcuma antinaia, Curcuma contravenenum, Andrographis paniculata, and Tanacetum parthenium; secondly to test similar structurally related molecules and finally to prepare and evaluate an efficient formulation against Ophiophagus hannah venom intoxification. Three labdane based compounds, including labdane dialdehyde, labdane lactone, and labdane trialdehyde and two lactones including 14-deoxy-11,12-didehydroandrographolide and parthenolide were isolated by column chromatography and characterised. Using the isolated rat phrenic nerve-hemidiaphragm preparation, the antagonistic effect of crude extracts, isolated compounds and prepared formulations were measured in vitro on the inhibition of the neuromuscular transmission. Inhibition on muscle contraction, produced by the 5 μg/mL venom, was reversed by test agents in organ bath preparations. A labdane trialdehyde, isolated from C. contravenenum, was identified as the best antagonising agent in the low micromolar range. Tests on formulations of the most potent C. contravenenum extract showed, that the suppository with witepsol H15 was an effective medicine against O. hannah venom. This study elucidated the active compounds, accounting for the antivenin activity of traditionally used herbs and suggested the most suitable formulation, which may help to develop potent medicines for the treatment of snake bite in the future.

Hannah's Feeding Journey: A Multidisciplinary Treatment Approach to Establishing Oral Acceptance for a Toddler with a Complex Medical History

ERIC Educational Resources Information Center

Dunn, Dena M.; Galbally, Sandra Lynn; Markowitz, Goldie; Pucci, Kristy N.; Brochi, Ligia; Cohen, Sherri Shubin

2017-01-01

This article presents the importance of multidisciplinary, family-centered care, and a developmental bio-psycho-social approach to treating feeding difficulties in a child with a complex medical history. Hannah spent the first 9 months of her life in the hospital and was discharged dependent on nasogastric tube feeding. Her journey to recovery…

Re-Envisioning Human Rights in the Light of Arendt and Rancière: Towards an Agonistic Account of Human Rights Education

ERIC Educational Resources Information Center

Zembylas, Michalinos

2017-01-01

This article takes up Arendt's "aporetic" framing of human rights as well as Rancière's critique and suggests that reading them together may offer a way to re-envision human rights and human rights education (HRE)--not only because they make visible the perplexities of human rights, but also in that they call for an agonistic…

Situating Systems Thinking between Past & Future: Hannah Arendt's Discourse on the Multicultural "World"

ERIC Educational Resources Information Center

Thoeun, Chanthou

2013-01-01

In this article, the author contends that there is by now a devastating catalogue of evidence revealing the depth and breadth of corporate-sponsored, government-sanctioned acts of violence against the environment across the globe. British Petroleum's (BP) oil spill, for instance, is a testament to large-scale catastrophic ecological damages…

On the impoverishment of scientific education.

PubMed

Dougherty, Edward R

2013-11-11

Hannah Arendt, one of the foremost political philosophers of the twentieth century, has argued that it is the responsibility of educators not to leave children in their own world but instead to bring them into the adult world so that, as adults, they can carry civilization forward to whatever challenges it will face by bringing to bear the learning of the past. In the same collection of essays, she discusses the recognition by modern science that Nature is inconceivable in terms of ordinary human conceptual categories - as she writes, 'unthinkable in terms of pure reason'. Together, these views on scientific education lead to an educational process that transforms children into adults, with a scientific adult being one who has the ability to conceptualize scientific systems independent of ordinary physical intuition. This article begins with Arendt's basic educational and scientific points and develops from them a critique of current scientific education in conjunction with an appeal to educate young scientists in a manner that allows them to fulfill their potential 'on the shoulders of giants'. While the article takes a general philosophical perspective, its specifics tend to be directed at biomedical education, in particular, how such education pertains to translational science.

Paleobotany of Livingston Island: The first report of a Cretaceous fossil flora from Hannah Point

USGS Publications Warehouse

Leppe, M.; Michea, W.; Muñoz, C.; Palma-Heldt, S.; Fernandoy, F.

2007-01-01

This is the first report of a fossil flora from Hannah Point, Livingston Island, South Shetland Islands, Antarctica. The fossiliferous content of an outcrop, located between two igneous rock units of Cretaceous age are mainly composed of leaf imprints and some fossil trunks. The leaf assemblage consists of 18 taxa of Pteridophyta, Pinophyta and one angiosperm. The plant assemblage can be compared to other Early Cretaceous floras from the South Shetland Islands, but several taxa have an evidently Late Cretaceous affinity. A Coniacian-Santonian age is the most probable age for the outcrops, supported by previous K/Ar isotopic studies of the basalts over and underlying the fossiliferous sequence

Interview: Investigating immunomodulators among the Actinomycetales. Interview by Hannah Wilson.

PubMed

Stanford, John L

2013-05-01

John L Stanford speaks to Hannah Wilson, Assistant Commissioning Editor John L Stanford is Chief Scientific Officer at BioEos Ltd (Kent, UK). Dr Stanford began his career as a senior lecturer and then reader in microbiology at Middlesex Hospital Medical School (London, UK), then University College London Medical School, where he became Professor in Medical Microbiology and Head of Department in 1997. He retired and became Professor Emeritus in 2004. Dr Stanford's career has been devoted to research into mycobacteria, the diseases that they cause and the practical uses of this research. His special interest in recent years has been the development of bacterial immunotherapeutics for a range of diseases including tuberculosis and cancer. Dr Stanford was one of the founding directors of Stanford Rook Ltd (London) and of BioEos Ltd, where he remains a director. He also played a part in the founding of Immodulon Therapeutics Ltd (London) and of a new company, ActinoPharma Ltd (London), and has published more than 200 peer-reviewed scientific papers.

War rape, natality and genocide.

PubMed

Schott, Robin May

2011-01-01

Feminist philosophy can make an important contribution to the field of genocide studies, and issues relating to gender and war are gaining new attention. In this article I trace legal and philosophical analyses of sexual violence against women in war. I analyze the strengths and limitations of the concept of social death—introduced into this field by Claudia Card—for understanding the genocidal features of war rape, and draw on the work of Hannah Arendt to understand the central harm of genocide as an assault on natality. The threat to natality posed by the harms of rape, forced pregnancy and forced maternity lie in the potential expulsion from the public world of certain groups—including women who are victims, members of the 'enemy' group, and children born of forced birth.

Capturing the worlds of multiple sclerosis: Hannah Laycock's photography.

PubMed

Bolaki, Stella

2017-03-01

This essay explores UK photographer Hannah Laycock's Awakenings and, to a lesser extent, Perceiving Identity that were created in 2015, following her diagnosis with multiple sclerosis (MS) in 2013. It draws on scholarship by people with chronic illness while situating these two MS projects in the context of Laycock's earlier art and portrait photography dealing with fragility, image and desire, and power relations between subject and observer. The analysis illustrates how her evocative photography captures the lived or subjective experience of an invisible and often misunderstood condition by initially focusing on the tension between transparency and opacity in her work. It further shows how her images counter dominant didactic metaphors such as, 'the body as machine', that perpetuate the dehumanising and objectifying aspects of medical care. Subsequent sections trace the influence that Oliver Sacks has had on Laycock's practice, and reflect on other metaphors and tropes in Awakenings that illuminate the relationship between body and self in MS. The essay concludes by acknowledging the therapeutic power of art and calling upon health professionals to make more use of such artistic work in clinical practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Antihemorrhagin in the blood serum of king cobra (Ophiophagus hannah): purification and characterization.

PubMed

Chanhome, Lawan; Khow, Orawan; Omori-Satoh, Tamotsu; Sitprija, Visith

2003-06-01

King cobra (Ophiophagus hannah) serum was found to possess antihemorrhagic activity against king cobra hemorrhagin. The activity was stronger than that in commercial king cobra antivenom. An antihemorrhagin has been purified by ion exchange chromatography, affinity chromatography and gel filtration with a 22-fold purification and an overall yield of 12% of the total antihemorrhagic activity contained in crude serum. The purified antihemorrhagin was homogeneous in disc-PAGE and SDS-PAGE. Its apparent molecular weight determined by SDS-PAGE was 120 kDa. The antihemorrhagin was also active against other hemorrhagic snake venoms obtained in Thailand and Japan such as Calloselasma rhodostoma, Trimeresurus albolabris, Trimeresurus macrops and Trimeresurus flavoviridis (Japanese Habu). It inhibited the proteolytic activity of king cobra venom. It is an acid- and thermolabile protein and does not form precipitin lines against king cobra venom.

The Place of Imagination in Inclusive Pedagogy: Thinking with Maxine Greene and Hannah Arendt

ERIC Educational Resources Information Center

Harwood, Valerie

2010-01-01

Conceptualising difference is a key task for inclusive pedagogy, and vital to the politics of inclusion. My purpose in this paper is to consider the place that imagination has in helping us to conceptualise difference, and to argue that imagination has a key part to play in inclusive pedagogy. To do this I draw closely on the work of Maxine Greene…

Interview: interview with P Jeffrey Conn. Interview by Hannah Coaker.

PubMed

Conn, P Jeffrey

2013-09-01

Dr Conn is the Lee E Limbird Professor of Pharmacology at Vanderbilt University and Director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD). Dr Conn received a PhD in Pharmacology from Vanderbilt in 1986 and pursued postdoctoral studies at Yale University. He served as a professor of Pharmacology at Emory University from 1988 to 2000, before moving to Merck and Co. (PA, USA) as head of the Department of Neuroscience. Dr Conn moved to Vanderbilt University in 2003 where he is the founding director of the VCNDD, with a primary mission of facilitating translation of recent advances in basic science to novel therapeutics. The VCNDD consists of approximately 100 full-time scientists and has advanced novel molecules from four major programs as development candidates for clinical testing with industry partners. Dr Conn has served in editorial positions with multiple international journals and has served the scientific advisory boards of multiple foundations and companies. He has received numerous awards based on the impact of his basic and translational research. Dr Conn's current research is focused on development of novel treatment strategies for schizophrenia, Parkinson's disease and other serious brain disorders. Interview conducted by Hannah Coaker, Assistant Commissioning Editor.

Envisioning Democracy: Participatory Filmmaking with Homeless Youth.

PubMed

Kennelly, Jacqueline

2018-05-01

This paper explores the democratic potential for participatory filmmaking with homeless youth, as well as the constraints and dilemmas associated with this visual method. Theorizing democracy through the work of Hannah Arendt and Pierre Bourdieu, the paper approaches democracy not as an end, but rather as a process that seeks to lessen social injustice. Bourdieu's work helps us appreciate, however, that this process is constrained by structures of inequality that shape access to the political dispositions that enable such engagement. Consistent with other research on low-income and marginalized young people, this study found that homeless youth engage with democracy through forms of community participation and mutual support, and are disinclined to orient toward liberal democratic structures such as voting and political parties, which they see as harmful or problematic. With a focus on one particular dilemma faced by the research team-namely, the question of how to make sense of and represent the issue of legalizing marijuana, which had been signaled by the youth participants as of primary political importance to them-the paper uses Arendt and Bourdieu to discuss how participatory filmmaking can help to expand the space of appearances available to homeless youth in Canadian society, and create a space at a shared table of understanding with middle class power brokers. © 2018 Canadian Sociological Association/La Société canadienne de sociologie.

Lessons for the anthropocene from the recent past: Tobacco use, HIV/AIDS, and social transformation

NASA Astrophysics Data System (ADS)

Travis, Charles; Holm, Poul

2017-09-01

In light of the dilemma of global climate change that we have presented ourselves with in the twenty-first century and beyond, many researchers express despair at the ability of humans and societies to change behavior. The paper identifies how global humanity at individual, institutional, and governmental levels have addressed life-threatening dangers in the recent past and begun processes of long-term corrective action. The paper thus discusses global social transformations from the recent past in regards to tobacco use and HIV/AIDS, to think about how Hannah Arendt's concept of the Polis detailed in The Human Condition (1958) may be engaged to address the human dimensions of climate change. As an output of the Andrew W. Mellon European Observatory of the New Human Condition, this paper's focus is commensurate with the thrust of this special issue of Global and Planetary Change which considers climate change to be more of a crisis in the human condition than an environmental problem. Arendt's concept of the Polis provides a framework for a better understanding of change in behavior, preference and motivation. We argue that her perspectives are central to developing multi and inter-disciplinary humanities, social science, science and business perspectives to mobilize collective human action towards adapting to and mitigating the social and environmental threats of global climate change.

Comments on "cyclical swings" by Professor Hannah Decker: The underappreciated "solid center" of psychiatry.

PubMed

Pies, Ronald W

2016-02-01

The history of psychiatry is characterized by some deep ideological and conceptual divisions, as adumbrated in Professor Hannah Decker's essay. However, the schism between "biological" and "psychosocial" models of mental illness and its treatment represents extreme positions among some psychiatrists-not the model propounded by academic psychiatry or its affiliated professional organizations. Indeed, the "biopsycho-social model" (BPSM) developed by Dr. George L. Engel has been, and remains, the foundational model for academic psychiatry, notwithstanding malign market forces that have undermined the BPSM's use in clinical practice. The BPSM is integrally related to "centralizing" and integrative trends in American psychiatry that may be traced to Franz Alexander, Karl Jaspers, and Engel himself, among others. This "Alexandrian-Jaspersian-Engelian" tradition is explored in relation to Professor Decker's "cyclical swing" model of psychiatry's history. (c) 2016 APA, all rights reserved).

The drama of nursing.

PubMed

Holmes, C A

1992-08-01

This exploratory paper considers a few possibilities for conceiving nursing as a form of aesthetic praxis. More specifically, drawing on the works of Erving Goffman on dramaturgy, and Elizabeth Burns on theatre, it makes some suggestions concerning nursing as a form of dramatic performance, and briefly attempts to relate this to concepts of praxis drawn from the writings of Hannah Arendt and critical social theorists. In contrast to Goffman's dramaturgy, which stresses the artifice of social relations and suggests a cynical view of human interactions, a critical theory of dramatic praxis introduces a normative dimension in which performance may become self-realizing and emancipatory as it aspires to the status of aesthetic praxis. Conceived in such terms, nursing practice becomes a powerful form of self-expression which has the potential to become liberating for the nurse and the patient.

Psychoanalysis and the Emigration of Central and Eastern European Intellectuals.

PubMed

Erős, Ferenc

2016-12-01

One of the most important phenomena in the intellectual history of the 20th century was the exodus of the European mind, the emigration of persons, ideas, techniques, and institutions in the vast areas of social, human, and natural sciences, as well as in literature and the visual arts. Among these exiled intellectuals, psychoanalysts formed a special group. This paper examines the major lines of the emigration of psychoanalysts from the countries of issue to the countries of reception. It focuses, in particular on Hungarian analysts and analytic candidates who left their country of birth in two waves, first after the failure of revolutions in 1918/19 for Berlin, and then after 1938, to escape the Nazis. The paper comments on the existential situation of émigré psychoanalysts in light of Hannah Arendt's writings on refugees.

Cloning and purification of alpha-neurotoxins from king cobra (Ophiophagus hannah).

PubMed

He, Ying-Ying; Lee, Wei-Hui; Zhang, Yun

2004-09-01

Thirteen complete and three partial cDNA sequences were cloned from the constructed king cobra (Ophiophagus hannah) venom gland cDNA library. Phylogenetic analysis of nucleotide sequences of king cobra with those from other snake venoms revealed that obtained cDNAs are highly homologous to snake venom alpha-neurotoxins. Alignment of deduced mature peptide sequences of the obtained clones with those of other reported alpha-neurotoxins from the king cobra venom indicates that our obtained 16 clones belong to long-chain neurotoxins (seven), short-chain neurotoxins (seven), weak toxin (one) and variant (one), respectively. Up to now, two out of 16 newly cloned king cobra alpha-neurotoxins have identical amino acid sequences with CM-11 and Oh-6A/6B, which have been characterized from the same venom. Furthermore, five long-chain alpha-neurotoxins and two short-chain alpha-neurotoxins were purified from crude venom and their N-terminal amino acid sequences were determined. The cDNAs encoding the putative precursors of the purified native peptide were also determined based on the N-terminal amino acid sequencing. The purified alpha-neurotoxins showed different lethal activities on mice.

Interview with James Bradner. Interviewed by Hannah Coaker.

PubMed

Bradner, James E

2013-08-01

James E Bradner is an Assistant Professor in Medicine at Harvard Medical School (MA, USA) as well as a Staff Physician in the Division of Hematologic Malignancies at Dana-Farber Cancer Institute (MA, USA). The present research focus of the Bradner laboratory concerns the discovery and optimization of prototype drugs targeting cancer gene regulation. The clinical objective of the Bradner group is to deliver novel therapeutics for human clinical investigation in hematologic diseases. Bradner's awards and honors include the Damon Runyon-Rachleff Innovation Award, the Smith Family Award for Excellence in Biomedical Research, the Dunkin' Donuts Rising Star Award and the HMS Distinguished Excellence in Teaching Award. He is a member of the American Society of Clinical Investigation, the American Society of Hematology, the American Chemical Society and the American Association of Cancer Research. His recent research has been published in Nature, Cell, Nature Chemical Biology and the Journal of the American Chemical Society. He has authored more than 20 US Patent applications, licensed to five pharmaceutical companies, and is a scientific founder of Acetylon Pharmaceuticals, SHAPE Pharmaceuticals, Tensha Therapeutics and Syros Pharmaceuticals. Bradner received his AB from Harvard University, his MD from the University of Chicago (IL, USA) and a MMS from Harvard Medical School. He completed his postgraduate training in Internal Medicine at Brigham & Women's Hospital (MA, USA), followed by a fellowship in Medical Oncology and Hematology at Dana-Farber Cancer Institute. Following additional post-doctoral training in Chemistry at Harvard University and the Broad Institute (MA, USA) with Professor Stuart Schreiber, Bradner joined the research faculty of Dana-Farber in 2008. Interview conducted by Hannah Coaker, Assistant Commissioning Editor.

Limitation and life in space

NASA Astrophysics Data System (ADS)

Israel, Marvin; Smith, T. Scott

1986-08-01

``The Earth is the very quintescence of the human condition...,'' says Hannah Arendt. Georg Simmel writes: ``The stranger is by nature no `owner of soil'—soil not only in the physical, but also in the figurative sense of a life-substance which is fixed, if not in a point in space, at least in an ideal point of social environment.'' How will no longer being Earthbound affect persons' experience of themselves and of others? Space colonization offers an opportunity for new self-definition by the alteration of existing limits. Thus ``limitation'' is a useful concept for exploring the physical, social and psychological significance of the colonization of space. Will people seek the security of routine, of convention, of hierarchy as in the military model governing our present-day astronauts? or will they seek to maximize the freedom inherent in extraordinary living conditions—as bohemians, deviants, travelers?

The crooked timber of identity: Integrating discursive, critical, and psychosocial analysis.

PubMed

Kaposi, David

2013-06-01

This paper seeks to contribute to the growing band of constructionist approaches within the field of identity studies (Wetherell & Moharty, 2010). First, it will review the developments that have taken place since the emergence of these approaches in the 1980s, identifying a state of fragmentation into local discursive, political-moral, and psychosocial levels of analysis. Second, and in order to challenge this fragmentation, it will present a rhetorical psychological (Billig, 1987, 1999a) analysis of the classic exchange of public letters between Israeli historian of Judaism Gershom Scholem and American political theorist Hannah Arendt in the wake of the latter's book Eichmann in Jerusalem (Arendt, 1994a). The analysis will proceed from local discursive action, through political-moral frameworks, to the nature of the writers' investment in these constructions. It will show that while the participants' implicitly occasioning of extreme identity categories (such as the 'Jewish anti-Semite' and the totalitarian-style religious Zionist ideologue) is a function of apparently incommensurable political-moral discourses, the nature of investment into such constructions may be understood in a mutual commitment to the absolute inalienability of Jewishness. Third, therefore, the paper will conclude that, rather than constituting separate 'levels', local discursive action, political-moral intelligibilities, and psychosocial qualities are mutually constitutive of each other. It is only through recognizing their inter-dependent nature that the complexity of identity may properly be addressed. ©2011 The British Psychological Society.

Institutional violence and humanization in health: notes to debate.

PubMed

Azeredo, Yuri Nishijima; Schraiber, Lilia Blima

2017-09-01

This paper starts from humanization policies and the academic debate around them to reflect about institutional violence inside health services. Based on research on scientific publications in Collective Health, it was observed that violence in relationships between health professionals and users - which is at the core of the humanization's debate - is conceptualized as an excessive power in exercise of professional authority. Using Hannah Arendt thinking as theoretical contributions regarding the concepts of 'authority', 'power' and 'violence', our objective is to define and rethink these phenomena. Melting these reflections with the history of institutionalization of health in Brazil, and especially the changes in medical work during the twentieth century, we conclude that the problem of institutional violence on health services is not based on excess of authority and power of professionals, but rather in its opposite. When there is a vacuum of professional authority, and relationships between people do not happen through power relations, there is space for the phenomenon of violence.

How to Exist Politically and Learn from It: Hannah Arendt and the Problem of Democratic Education

ERIC Educational Resources Information Center

Biesta, Gert

2010-01-01

Background/Context: In discussions about democratic education, there is a strong tendency to see the role of education as that of the preparation of children and young people for their future participation in democratic life. A major problem with this view is that it relies on the idea that the guarantee for democracy lies in the existence of a…

Analysis of the efficacy of Taiwanese freeze-dried neurotoxic antivenom against Naja kaouthia, Naja siamensis and Ophiophagus hannah through proteomics and animal model approaches.

PubMed

Liu, Chien-Chun; You, Chen-Hsien; Wang, Po-Jung; Yu, Jau-Song; Huang, Guo-Jen; Liu, Chien-Hsin; Hsieh, Wen-Chin; Lin, Chih-Chuan

2017-12-01

In Southeast Asia, envenoming resulting from cobra snakebites is an important public health issue in many regions, and antivenom therapy is the standard treatment for the snakebite. Because these cobras share a close evolutionary history, the amino acid sequences of major venom components in different snakes are very similar. Therefore, either monovalent or polyvalent antivenoms may offer paraspecific protection against envenomation of humans by several different snakes. In Taiwan, a bivalent antivenom-freeze-dried neurotoxic antivenom (FNAV)-against Bungarus multicinctus and Naja atra is available. However, whether this antivenom is also capable of neutralizing the venom of other species of snakes is not known. Here, to expand the clinical application of Taiwanese FNAV, we used an animal model to evaluate the neutralizing ability of FNAV against the venoms of three common snakes in Southeast Asia, including two 'true' cobras Naja kaouthia (Thailand) and Naja siamensis (Thailand), and the king cobra Ophiophagus hannah (Indonesia). We further applied mass spectrometry (MS)-based proteomic techniques to characterize venom proteomes and identify FNAV-recognizable antigens in the venoms of these Asian snakes. Neutralization assays in a mouse model showed that FNAV effectively neutralized the lethality of N. kaouthia and N. siamensis venoms, but not O. hannah venom. MS-based venom protein identification results further revealed that FNAV strongly recognized three-finger toxin and phospholipase A2, the major protein components of N. kaouthia and N. siamensis venoms. The characterization of venom proteomes and identification of FNAV-recognizable venom antigens may help researchers to further develop more effective antivenom designed to block the toxicity of dominant toxic proteins, with the ultimate goal of achieving broadly therapeutic effects against these cobra snakebites.

A clear case for conscience in healthcare practice.

PubMed

Birchley, Giles

2012-01-01

The value of conscience in healthcare ethics is widely debated. While some sources present it as an unquestionably positive attribute, others question both the veracity of its decisions and the effect of conscientious objection on patient access to health care. This paper argues that the right to object conscientiously should be broadened, subject to certain previsos, as there are many benefits to healthcare practice in the development of the consciences of practitioners. While effects such as the preservation of moral integrity are widely considered to benefit practitioners, this paper draws on the work of Hannah Arendt to offer several original arguments in defence of conscience that may more directly benefit patients, namely that a pang of conscience may be useful in rapidly unfolding situations in which there is no time to reflect satisfactorily upon activities and that, given the hierarchical nature of healthcare institutions, a right to defy authority on the basis of conscience may benefit junior staff who lack the institutional power to challenge the orders of superiors.

Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches.

PubMed

Petras, Daniel; Heiss, Paul; Süssmuth, Roderich D; Calvete, Juan J

2015-06-05

We report on the first application of top-down mass spectrometry in snake venomics. De novo sequence tags generated by, and ProSight Lite supported analysis of, combined collisional based dissotiations (CID and HCD) recorded in a hybrid LTQ Orbitrap instrument in data-dependent mode identified a number of proteins from different toxin families, namely, 11 three-finger toxins (7-7.9 kDa), a Kunitz-type inhibitor (6.3 kDa), ohanin (11.9 kDa), a novel phospholipase A2 molecule (13.8 kDa), and the cysteine-rich secretory protein (CRISP) ophanin (25 kDa) from Indonesian king cobra venom. Complementary bottom-up MS/MS analyses contributed to the completion of a locus-resolved venom phenotypic map for Ophiophagus hannah, the world's longest venomous snake and a species of medical concern across its wide distribution range in forests from India to Southeast Asia. Its venom composition, comprising 32-35 proteins/peptides from 10 protein families, is dominated by α-neurotoxins and convincingly explains the main neurotoxic effects of human envenoming caused by king cobra bite. The integration of efficient chromatographic separation of the venom's components and locus-resolved toxin identification through top-down and bottom-up MS/MS-based species-specific database searching and de novo sequencing holds promise that the future will be bright for the field of venom research.

Antiproliferative activity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase.

PubMed

Li Lee, Mui; Chung, Ivy; Yee Fung, Shin; Kanthimathi, M S; Hong Tan, Nget

2014-04-01

King cobra (Ophiophagus hannah) venom L-amino acid oxidase (LAAO), a heat-stable enzyme, is an extremely potent antiproliferative agent against cancer cells when compared with LAAO isolated from other snake venoms. King cobra venom LAAO was shown to exhibit very strong antiproliferative activities against MCF-7 (human breast adenocarcinoma) and A549 (human lung adenocarcinoma) cells, with an IC50 value of 0.04±0.00 and 0.05±0.00 μg/mL, respectively, after 72-hr treatment. In comparison, its cytotoxicity was about 3-4 times lower when tested against human non-tumourigenic breast (184B5) and lung (NL 20) cells, suggesting selective antitumour activity. Furthermore, its potency in MCF-7 and A549 cell lines was greater than the effects of doxorubicin, a clinically established cancer chemotherapeutic agent, which showed an IC50 value of 0.18±0.03 and 0.63±0.21 μg/mL, respectively, against the two cell lines. The selective cytotoxic action of the LAAO was confirmed by phycoerythrin (PE) annexin V/7-amino-actinomycin (AAD) apoptotic assay, in which a significant increase in apoptotic cells was observed in LAAO-treated tumour cells than in their non-tumourigenic counterparts. The ability of LAAO to induce apoptosis in tumour cells was further demonstrated using caspase-3/7 and DNA fragmentation assays. We also determined that this enzyme may target oxidative stress in its killing of tumour cells, as its cytotoxicity was significantly reduced in the presence of catalase (a H2O2 scavenger). In view of its heat stability and selective and potent cytotoxic action on cancer cells, king cobra venom LAAO can be potentially developed for treating solid tumours. © 2013 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

HannaH phase III randomised study: Association of total pathological complete response with event-free survival in HER2-positive early breast cancer treated with neoadjuvant-adjuvant trastuzumab after 2 years of treatment-free follow-up.

PubMed

Jackisch, Christian; Hegg, Roberto; Stroyakovskiy, Daniil; Ahn, Jin-Seok; Melichar, Bohuslav; Chen, Shin-Cheh; Kim, Sung-Bae; Lichinitser, Mikhail; Starosławska, Elżbieta; Kunz, Georg; Falcon, Silvia; Chen, Shou-Tung; Crepelle-Fléchais, Aulde; Heinzmann, Dominik; Shing, Mona; Pivot, Xavier

2016-07-01

In the phase III, open-label, randomised HannaH study, fixed-dose neoadjuvant-adjuvant subcutaneous trastuzumab for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer was non-inferior to standard weight-based intravenous infusion in terms of serum trough concentration and pathological complete response (pCR). Evidence suggests that pCR, particularly total pCR (tpCR), is likely to predict clinical benefit. We report associations between tpCR and event-free survival (EFS) from HannaH (the largest population from a single study of patients presenting with newly diagnosed HER2-positive breast cancer treated with neoadjuvant-adjuvant trastuzumab to date) plus long-term efficacy and safety. Eligible patients received four cycles of neoadjuvant docetaxel followed by four cycles of fluorouracil/epirubicin/cyclophosphamide administered concurrently with 3-weekly subcutaneous (600 mg fixed dose) or intravenous trastuzumab (8 mg/kg loading, 6 mg/kg maintenance doses). Post-surgery, patients received adjuvant trastuzumab as randomised to complete 1 year of standard treatment. In exploratory analyses, we used Cox regression to assess associations between tpCR and EFS. EFS rates per subgroup were estimated using the Kaplan-Meier method. Three-year EFS rates were 76% for subcutaneous and 73% for intravenous trastuzumab (unstratified hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.69-1.30; intention-to-treat population). Three-year overall survival rates were 92% for subcutaneous and 90% for intravenous trastuzumab (unstratified HR 0.76, 95% CI 0.44-1.32). tpCR was associated with a reduced risk of an EFS event: subcutaneous arm HR 0.38 (95% CI 0.22-0.65); intravenous arm HR 0.32 (95% CI 0.18-0.60). Results were similar for subgroups, including oestrogen receptor status. The few additional adverse events occurring during treatment-free follow-up were balanced between arms. Long-term efficacy supports the established non-inferiority of

Toward a critical ethical reflexivity: phenomenology and language in Maurice Merleau-Ponty.

PubMed

Murray, Stuart J; Holmes, Dave

2013-07-01

Working within the tradition of continental philosophy, this article argues in favour of a phenomenological understanding of language as a crucial component of bioethical inquiry. The authors challenge the 'commonsense' view of language, in which thinking appears as prior to speaking, and speech the straightforward vehicle of pre-existing thoughts. Drawing on Maurice Merleau-Ponty's (1908-1961) phenomenology of language, the authors claim that thinking takes place in and through the spoken word, in and through embodied language. This view resituates bioethics as a matter of bodies that speak. It also refigures the meaning of ethical self-reflexion, and in so doing offers an alternative view on reflexivity and critique. Referring to the Kantian critical tradition and its reception by Hannah Arendt and Michel Foucault, we advance a position we call 'critical ethical reflexivity'. We contend that Merleau-Ponty's phenomenology of language offers valuable insight into ethical reflexivity and subject formation. Moreover, his understanding of language may foster new qualitative empirical research in bioethics, lead to more nuanced methods for interpreting personal narratives, and promote critical self-reflexion as necessary for bioethical inquiry. © 2013 John Wiley & Sons Ltd.

Healthcare access as a right, not a privilege: a construct of Western thought.

PubMed

Papadimos, Thomas J

2007-03-28

Over 45 million Americans are uninsured or underinsured. Those living in poverty exhibit the worst health status. Employment, education, income, and race are important factors in a person's ability to acquire healthcare access. Having established that there are people lacking healthcare access due to multi-factorial etiologies, the question arises as to whether the intervention necessary to assist them in obtaining such access should be considered a privilege, or a right. The right to healthcare access is examined from the perspective of Western thought. Specifically through the works of Aristotle, Immanuel Kant, Thomas Hobbes, Thomas Paine, Hannah Arendt, James Rawls, and Norman Daniels, which are accompanied by a contemporary example of intervention on behalf of the medically needy by the The Johns Hopkins Urban Health Institute. As human beings we are all valuable social entities whereby, through the force of morality, through implicitly forged covenants among us as individuals and between us and our governments, and through the natural rights we maintain as individuals and those we collectively surrender to the common good, it has been determined by nature, natural laws, and natural rights that human beings have the right, not the privilege, to healthcare access.

Healthcare access as a right, not a privilege: a construct of Western thought

PubMed Central

Papadimos, Thomas J

2007-01-01

Over 45 million Americans are uninsured or underinsured. Those living in poverty exhibit the worst health status. Employment, education, income, and race are important factors in a person's ability to acquire healthcare access. Having established that there are people lacking healthcare access due to multi-factorial etiologies, the question arises as to whether the intervention necessary to assist them in obtaining such access should be considered a privilege, or a right. The right to healthcare access is examined from the perspective of Western thought. Specifically through the works of Aristotle, Immanuel Kant, Thomas Hobbes, Thomas Paine, Hannah Arendt, James Rawls, and Norman Daniels, which are accompanied by a contemporary example of intervention on behalf of the medically needy by the The Johns Hopkins Urban Health Institute. As human beings we are all valuable social entities whereby, through the force of morality, through implicitly forged covenants among us as individuals and between us and our governments, and through the natural rights we maintain as individuals and those we collectively surrender to the common good, it has been determined by nature, natural laws, and natural rights that human beings have the right, not the privilege, to healthcare access. PMID:17391522

Cross-reactivity and neutralization of Indian King cobra (Ophiophagus hannah) venom by polyvalent and monovalent antivenoms.

PubMed

Gowtham, Yashonandana J; Mahadeswaraswamy, Y H; Girish, K S; K, Kemparaju

2014-07-01

The venom of the largest venomous snake, the king cobra (Ophiophagus hannah), is still out of league for the production of therapeutic polyvalent antivenom nor it is characterized immunologically in the Indian subcontinent. In the present study, the king cobra venom is comparatively studied for the cross-reactivity/reactivity and toxicity neutralization by the locally available equine therapeutic polyvalent BSV and VB antivenoms, and monovalent antivenom (OH-IgG) prepared in rabbit. None of the two therapeutic antivenoms procured from two different firms showed any signs of cross-reactivity in terms of antigen-antibody precipitin lines in immunodouble diffusion assay; however, a weak and an insignificant cross-reactivity pattern was observed in ELISA and Western blot studies. Further, both BSV and VB antivenoms failed to neutralize proteolytic, hyaluronidase and phospholipase activities as well as toxic properties such as edema, myotoxicity and lethality of the venom. As expected, OH-IgG showed strong reactivity in immunodouble diffusion, ELISA and in Western blot analysis and also neutralized both enzyme activities as well as the toxic properties of the venom. Thus, the study provides insight into the likely measures that are to be taken in cases of accidental king cobra bites for which the Indian subcontinent is still not prepared for. Copyright © 2014 Elsevier B.V. All rights reserved.

On the impovesrishment of scientific education

PubMed Central

2013-01-01

Hannah Arendt, one of the foremost political philosophers of the twentieth century, has argued that it is the responsibility of educators not to leave children in their own world but instead to bring them into the adult world so that, as adults, they can carry civilization forward to whatever challenges it will face by bringing to bear the learning of the past. In the same collection of essays, she discusses the recognition by modern science that Nature is inconceivable in terms of ordinary human conceptual categories - as she writes, ‘unthinkable in terms of pure reason’. Together, these views on scientific education lead to an educational process that transforms children into adults, with a scientific adult being one who has the ability to conceptualize scientific systems independent of ordinary physical intuition. This article begins with Arendt’s basic educational and scientific points and develops from them a critique of current scientific education in conjunction with an appeal to educate young scientists in a manner that allows them to fulfill their potential ‘on the shoulders of giants’. While the article takes a general philosophical perspective, its specifics tend to be directed at biomedical education, in particular, how such education pertains to translational science. PMID:24215841

Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra).

PubMed

Roy, Amrita; Zhou, Xingding; Chong, Ming Zhi; D'hoedt, Dieter; Foo, Chun Shin; Rajagopalan, Nandhakishore; Nirthanan, Selvanayagam; Bertrand, Daniel; Sivaraman, J; Kini, R Manjunatha

2010-03-12

Snake venoms are a mixture of pharmacologically active proteins and polypeptides that have led to the development of molecular probes and therapeutic agents. Here, we describe the structural and functional characterization of a novel neurotoxin, haditoxin, from the venom of Ophiophagus hannah (King cobra). Haditoxin exhibited novel pharmacology with antagonism toward muscle (alphabetagammadelta) and neuronal (alpha(7), alpha(3)beta(2), and alpha(4)beta(2)) nicotinic acetylcholine receptors (nAChRs) with highest affinity for alpha(7)-nAChRs. The high resolution (1.5 A) crystal structure revealed haditoxin to be a homodimer, like kappa-neurotoxins, which target neuronal alpha(3)beta(2)- and alpha(4)beta(2)-nAChRs. Interestingly however, the monomeric subunits of haditoxin were composed of a three-finger protein fold typical of curaremimetic short-chain alpha-neurotoxins. Biochemical studies confirmed that it existed as a non-covalent dimer species in solution. Its structural similarity to short-chain alpha-neurotoxins and kappa-neurotoxins notwithstanding, haditoxin exhibited unique blockade of alpha(7)-nAChRs (IC(50) 180 nm), which is recognized by neither short-chain alpha-neurotoxins nor kappa-neurotoxins. This is the first report of a dimeric short-chain alpha-neurotoxin interacting with neuronal alpha(7)-nAChRs as well as the first homodimeric three-finger toxin to interact with muscle nAChRs.

Molecular mechanism of cell death induced by king cobra (Ophiophagus hannah) venom l-amino acid oxidase.

PubMed

Fung, Shin Yee; Lee, Mui Li; Tan, Nget Hong

2015-03-01

Snake venom LAAOs have been reported to exhibit a wide range of pharmacological activities, including cytotoxic, edema-inducing, platelet aggregation-inducing/platelet aggregation-inhibiting, bactericidal and antiviral activities. A heat-stable form of l-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom (OH-LAAO) has been shown to exhibit very potent cytotoxicity against human tumorigenic cells but not in their non-tumorigenic counterparts, and the cytotoxicity was due to the apoptosis-inducing effect of the enzyme. In this work, the molecular mechanism of cell death induced by OH-LAAO was investigated. The enzyme exerts its apoptosis-inducing effect presumably via both intrinsic and extrinsic pathways as suggested by the increase in caspase-8 and -9 activities. Oligonucleotide microarray analysis showed that the expression of a total of 178 genes was significantly altered as a result of oxidative stress induced by the hydrogen peroxide generated by the enzyme. Of the 178 genes, at least 27 genes are involved in apoptosis and cell death. These alterations of gene expression was presumably caused by the direct cytotoxic effect of H2O2 generated during the enzymatic reaction, as well as the non-specific oxidative modifications of signaling molecules that eventually lead to apoptosis and cell death. The very substantial up-regulation of cytochrome P450 genes may also contribute to the potent cytotoxic action of OH-LAAO by producing excessive reactive oxygen species (ROS). In conclusion, the potent apoptosis inducing activity of OH-LAAO was likely due to the direct cytotoxic effect of H2O2 generated during the enzymatic reaction, as well as the non-specific oxidation of signalling molecules. Copyright © 2015 Elsevier Ltd. All rights reserved.

Hematology, morphology, cytochemical staining, and ultrastuctural characteristics of blood cells in king cobras (Ophiophagus hannah).

PubMed

Salakij, Chaleow; Salakij, Jarernsak; Apibal, Suntaree; Narkkong, Nual-Anong; Chanhome, Lawan; Rochanapat, Nirachara

2002-01-01

King cobras (Ophiophagus hannah) have been captive-bred at Queen Saovabha Memorial Institute since 1996 to supply venom for antivenom production. Hematologic tests would be useful for evaluating the health of the snakes, however, basic hematologic data and morphology have not been described for this species. The purpose of this study was to determine basic hematologic values and evaluate light microscopic, cytochemical, and electron microscopic characteristics of king cobra blood cells. Blood samples from 13 wild-caught and 15 captive-bred king cobras were collected into EDTA from the ventral caudal vein. A CBC was done using standard methods. Significant differences between groups were determined using t-tests. Cytochemical stains (periodic acid-Schiff [PAS], Sudan black B [SBB], alpha-naphthyl acetate esterase [ANAE], acid phosphatase [AcP], and beta-glucuronidase [beta-glu]), and scanning and transmission electron microscopy were done using standard techniques. Eighteen snakes (64.3%) were positive for Hepatozoon infection. Hepatozoon organisms were detected nearly twice as frequently in wild-caught (11/13) as in captive-bred (7/15) snakes. Total WBC, azurophil, and lymphocyte counts were higher and fibrinogen concentration was lower in Hepatozoon-positive snakes. Captive-bred snakes had higher RBC values, lower azurophil, heterophil, and punctate reticulocyte percentages, and higher lymphocyte numbers compared with wild-caught snakes. Lymphocytes were the most commonly observed WBCs, and stained positive with PAS, ANAE, AcP, and beta-glu. Azurophil granules stained positive with SBB, PAS, and ANAE. Heterophils were the largest WBCs; their granules stained with SBB, ANAE, and beta-glu. Basophil granules stained with PAS, SBB, ANAE, and beta-glu. Thrombocytes were strongly positive with PAS. Transmission electron microscopic examination revealed organelles within all WBCs except eosinophils and revealed the gamonts of Hepatozoon sp in RBCs and azurophils. These

Towards an ethics of authentic practice.

PubMed

Murray, Stuart J; Holmes, Dave; Perron, Amélie; Rail, Geneviève

2008-10-01

This essay asks how we might best elaborate an ethics of authentic practice. Will we be able to agree on a set of shared terms through which ethical practice will be understood? How will we define ethics and the subject's relation to authoritative structures of power and knowledge? We begin by further clarifying our critique of evidence-based medicine (EBM), reflecting on the intimate relation between theory and practice. We challenge the charge that our position amounts to no more than 'subjectivism' and 'antiauthoritarian' theory. We argue that an ethical practice ought to question the authority of EBM without falling into the trap of dogmatic antiauthoritarianism. In this, we take up the work of Hannah Arendt, who offers terms to help understand our difficult political relation to authority in an authentic ethical practice. We continue with a discussion of Michel Foucault's use of 'free speech' or parrhesia, which he adopts from Ancient Greek philosophy. Foucault demonstrates that authentic ethical practice demands that we 'speak truth to power.' We conclude with a consideration of recent biotechnologies, and suggest that these biomedical practices force us to re-evaluate our theoretical understanding of the ethical subject. We believe that we are at a crucial juncture: we must develop an ethics of authentic practice that will be commensurable with new and emergent biomedical subjectivities.

Antibacterial action of a heat-stable form of L-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom.

PubMed

Lee, Mui Li; Tan, Nget Hong; Fung, Shin Yee; Sekaran, Shamala Devi

2011-03-01

The major l-amino acid oxidase (LAAO, EC 1.4.3.2) of king cobra (Ophiophagus hannah) venom is known to be an unusual form of snake venom LAAO as it possesses unique structural features and unusual thermal stability. The antibacterial effects of king cobra venom LAAO were tested against several strains of clinical isolates including Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli using broth microdilution assay. For comparison, the antibacterial effects of several antibiotics (cefotaxime, kanamycin, tetracycline, vancomycin and penicillin) were also examined using the same conditions. King cobra venom LAAO was very effective in inhibiting the two Gram-positive bacteria (S. aureus and S. epidermidis) tested, with minimum inhibitory concentration (MIC) of 0.78μg/mL (0.006μM) and 1.56μg/mL (0.012μM) against S. aureus and S. epidermidis, respectively. The MICs are comparable to the MICs of the antibiotics tested, on a weight basis. However, the LAAO was only moderately effective against three Gram-negative bacteria tested (P. aeruginosa, K. pneumoniae and E. coli), with MIC ranges from 25 to 50μg/mL (0.2-0.4μM). Catalase at the concentration of 1mg/mL abolished the antibacterial effect of LAAO, indicating that the antibacterial effect of the enzyme involves generation of hydrogen peroxide. Binding studies indicated that king cobra venom LAAO binds strongly to the Gram-positive S. aureus and S. epidermidis, but less strongly to the Gram-negative E. coli and P. aeruginosa, indicating that specific binding to bacteria is important for the potent antibacterial activity of the enzyme. Copyright © 2010 Elsevier Inc. All rights reserved.

`Not to escape the world but to join it': responding to climate change with imagination not fantasy

NASA Astrophysics Data System (ADS)

Davison, Andrew

2017-05-01

The work of climate scientists, demonstrating human-driven climate change, has not provoked the widespread and far-reaching changes to human behaviour necessary to avert potentially catastrophic environmental trajectories. This work has not yet sufficiently been able to engage the individual and collective imagination. Drawing on Samuel Taylor Coleridge (1772-1834) and Iris Murdoch (1919-1999), we can distinguish two modes under which the human imagination can operate: in Murdoch's terms, these are `imagination' and `fantasy'. To relate imaginatively is to be willing to allow one's internal image of the world to be changed by what one encounters, while an outlook characterized by fantasy relates to the world as one would wish it were, rather than how it actually is. Fantasy, therefore, operates not only among those who deny climate change, but also among those who entertain the promise of a technological solution too optimistically. An imaginative outlook, by contrast, evaluates actions and patterns of behaviour in terms of their relation to a wider whole. This is necessary for providing the degree of agency required to step out of a cycle of ever accelerating production, which is explored in terms of an analogy to a discussion of revenge and forgiveness from Hannah Arendt (1906-1975). Ultimately, the need to engage the imagination is an opportunity as well as a challenge. To live imaginatively is fulfilling, and that is precisely what the challenges of climate change require. This article is part of the themed issue 'Material demand reduction'.

Toddler “Functionally Cured” of HIV Infection | NIH MedlinePlus the Magazine

MedlinePlus

... Table of Contents Pediatric HIV specialist Dr. Hannah Gay of the University of Mississippi Medical Center led ... infected mother. Under the medical care of Hannah Gay, M.D., a pediatric HIV specialist at the ...

77 FR 71003 - Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-28

... lead USG coordinating agency on the World Health Organization and its related work, including... DEPARTMENT OF HEALTH AND HUMAN SERVICES Notice of Public Meeting AGENCY: Office of Global Affairs... Hannah Burris, Office of Global Affairs, U.S. Department of Health and Human Services. Email: hannah...

Cooperate! A paradigm shift for health equity.

PubMed

Chang, Wei-Ching; Fraser, Joy H

2017-02-21

The role of competition and cooperation in relation to the goal of health equity is examined in this paper. The authors explain why the win-lose mentality associated with avoidable competition is ethically questionable and less effective than cooperation in achieving positive outcomes, particularly as it relates to health and health equity. Competition, which differentiates winners from losers, often with the winner-takes-all reward system, inevitably leads to a few winners and many losers, resulting in social inequality, which, in turn, engenders and perpetuates health inequity.Competitive market-driven approaches to healthcare-brought about by capitalism, neo-liberalization, and globalization, based primarily on a competitive framework-are shown to have contributed to growing inequities with respect to the social determinants of health, and have undermined equal opportunity to access health care and achieve health equity. It is possible to redistribute income and wealth to reduce social inequality, but globalization poses increasing challenges to policy makers. John Stuart Mill provided a passionate, philosophical defense of cooperatives, followed by Karl Polanyi who offered an insightful critique of both state socialism and especially the self-regulating market, thereby opening up the cooperative way of shaping the future. We cite Hannah Arendt's "the banality of evil" to characterize the tragic concept of "ethical fading" witnessed in business and everyday life all over the world, often committed (without thinking and reflecting) by ordinary people under competitive pressures.To promote equity in health for all, we recommend the adoption of a radically new cooperation paradigm, applied whenever possible, to everything in our daily lives.

'Not to escape the world but to join it': responding to climate change with imagination not fantasy.

PubMed

Davison, Andrew

2017-06-13

The work of climate scientists, demonstrating human-driven climate change, has not provoked the widespread and far-reaching changes to human behaviour necessary to avert potentially catastrophic environmental trajectories. This work has not yet sufficiently been able to engage the individual and collective imagination. Drawing on Samuel Taylor Coleridge (1772-1834) and Iris Murdoch (1919-1999), we can distinguish two modes under which the human imagination can operate: in Murdoch's terms, these are 'imagination' and 'fantasy'. To relate imaginatively is to be willing to allow one's internal image of the world to be changed by what one encounters, while an outlook characterized by fantasy relates to the world as one would wish it were, rather than how it actually is. Fantasy, therefore, operates not only among those who deny climate change, but also among those who entertain the promise of a technological solution too optimistically. An imaginative outlook, by contrast, evaluates actions and patterns of behaviour in terms of their relation to a wider whole. This is necessary for providing the degree of agency required to step out of a cycle of ever accelerating production, which is explored in terms of an analogy to a discussion of revenge and forgiveness from Hannah Arendt (1906-1975). Ultimately, the need to engage the imagination is an opportunity as well as a challenge. To live imaginatively is fulfilling, and that is precisely what the challenges of climate change require.This article is part of the themed issue 'Material demand reduction'. © 2017 The Author(s).

The many faces of autonomy.

PubMed

Gracia, Diego

2012-02-01

What does autonomy mean from a moral point of view? Throughout Western history, autonomy has had no less than four different meanings. The first is political: the capacity of old cities and modern states to give themselves their own laws. The second is metaphysical, and was introduced by Kant in the second half of the 18th century. In this meaning, autonomy is understood as an intrinsic characteristic of all rational beings. Opposed to this is the legal meaning, in which actions are called autonomous when performed with due information and competency and without coercion. This last meaning, the most frequently used in bioethics, is primarily legal instead of moral. Is there a proper moral meaning of the word autonomy? If so, this would be a fourth meaning. Acts can only be called moral when they are postconventional (using the terminology coined by Lawrence Kohlberg), inner-directed (as expressed by David Riesman), and responsible (according to Hannah Arendt). Such acts are autonomous in this new, fourth, and to my mind, the only one proper, moral meaning. The goal of ethics cannot be other than forming human beings capable of making autonomous and responsible decisions, and doing so because they think this is their duty and not because of any other nonmoral motivation, like comfort, convenience, or satisfaction. The goal of ethics is to promote postconventional and mature human beings. This was what Socrates tried to do with the young people of Athens. And it is also the objective of every course of ethics and of any process of training.

The politics of corruption, inequality, and the socially excluded.

PubMed

Santos Salas, Anna

2013-07-01

In this article, the production of knowledge in the context of socially excluded people exposed to inequality, oppression, and exploitation is problematized. The analysis follows Enrique Dussel's philosophical exegesis of the politics of power and corruption and his vision of a critical transformation of the social political order. The argument is also informed by the work of critical educator Paulo Freire, who elucidates the conditions of oppression and marginalization and highlights the importance of conscientization to develop a critical awareness of these conditions. Hannah Arendt's work on the politics of understanding totalitarianism also assists in the elucidation of the machinery that operates behind oppression to sustain power and inequality. The article emphasizes the need to recognize the inequality of conditions that exists between the producer of knowledge and those who live through inequality and oppression in their lived corporality. A critical transformation of the process of production of knowledge is needed to both acknowledge the conditions that sustain this endeavour in the first place and avoid the corruption of knowledge. A work of conscientization is also necessary among knowledge producers to undertake a critical analysis of inequality that exposes the corruption of power. This analysis needs to examine and unmask the hidden mechanisms that perpetuate inequality and oppression and serve only the interests of a few. The abysmal gaps between the wealthy and the poor within and among countries bespeak a degree of human indifference that reflects a most serious and complex phenomenon that perverts something profoundly human in our societies. © 2013 John Wiley & Sons Ltd.

Potential for Conflict in South America

DTIC Science & Technology

1988-06-01

34Anglo-Argentine War." 2 Dov S. Zakheim, "The South Atlantic Conflict: Strategic, Military, and Technological Lessons", in Alberto Coll and Anthony Arendt...For example, Brazil’s period of greatest military growth after the war was during the civilian qovernment or Juscelino Kubitschek (1956-61); Joao ...W. Goodman and Juan Riel, eds., Civil Military Relations in Latin America: The Military ana Fower, c. August 1987. Coll, Alberto , and Anthony Arendt

Violence among peoples in the light of human frustration and aggression.

PubMed

de Gaay Fortman, Bas

2005-12-05

This article sets out to provide a general background to the study of aggression in the social sciences, with a particular focus on its link to collective violence. While the study of what happens in the human brain appears to be already highly complex, analysis of violent behavior appears to be even more intricate. A deductive system in the sense of a general and clear system of propositions logically connected to one another is not feasible, principally because contrary to the natural sciences there are no verities but merely "stylized facts." One of these concerns the setting of human aggression in the light of frustration, as argued in the frustration-aggression hypothesis developed by Dollard et al. in 1939. Apart from conceiving of aggression as a pure human instinct, it may also be seen as externally driven, while a third possibility concerns culturally "learned" aggression. Proof of the latter is that the strongest correlation appears to be that between current violence and previous manifestations thereof. Attention is paid to the way in which Gurr has rooted his relative deprivation theory on causes of collective violence among peoples in mechanisms of frustration and aggression. That theory is taken a bit further in terms of "perceived acquirement failure," which appears to be highly connected to the role of the state. Based on certain observations by Hannah Arendt, the argument then proceeds to violence as a manifestation of powerlessness. Finally, this leads to a discussion of justice as a crucial factor in what Durkheim used to call a "right to conflict." In this way, human aggression is placed in a broad socio-economic context.

The Development of a Leadership Self-Efficacy Measure

DTIC Science & Technology

2010-03-01

motivation to regulate current behaviors” (Hannah el al., 2008: 677). This self-motivation efficacy has been an    14    important part of many...to become a source of motivation to regulate current behaviors (Hannah el al., 2008: 677). The second factor contained the following items...priorities are 20. Understanding what he/she is expected to do 21. Taking charge at appropriate times 22. Supporting human relations and EEOC programs 23

Enhancement and Angular Dependence of Transport Critical Current Density in Pulsed Laser Deposited YBa2Cu3O7-x+BaSnO3 Films in Applied Magnetic Fields (Postprint)

DTIC Science & Technology

2007-09-25

Foltyn, Q. X. Jia, H. Wang, A. Serquis, L. Civale, B. Maiorov, M. E. Hawley , M. P. Maley, and D. E. Peterson, Nat. Mater. 3, 439 2004. 4C...J. O. Willis , J. Y. Coulter, H. Wang, Q. X. Jia, P. N. Arendt, J. L. MacManus-Driscoll, M. P. Maley, and S. R. Foltyn, Appl. Phys. Lett. 84, 2121...Jia, P. N. Arendt, H. Wang, J. O. Willis , J. Y. Coulter, T. G. Holesinger, J. L. MacManus- Driscoll, M. W. Rupich, W. Zhang, and X. Li, Physica C

King cobra (Ophiophagus hannah) venom L-amino acid oxidase induces apoptosis in PC-3 cells and suppresses PC-3 solid tumor growth in a tumor xenograft mouse model.

PubMed

Lee, Mui Li; Fung, Shin Yee; Chung, Ivy; Pailoor, Jayalakshmi; Cheah, Swee Hung; Tan, Nget Hong

2014-01-01

King cobra (Ophiophagus hannah) venom L-amino acid oxidase (OH-LAAO), a heat stable enzyme, has been shown to exhibit very potent anti-proliferative activity against human breast and lung tumorigenic cells but not in their non-tumorigenic counterparts. We further examine its in vitro and in vivo anti-tumor activity in a human prostate adenocarcinoma (PC-3) model. OH-LAAO demonstrated potent cytotoxicity against PC-3 cells with IC50 of 0.05 µg/mL after 72 h incubation in vitro. It induced apoptosis as evidenced with an increase in caspase-3/7 cleavages and an increase in annexin V-stained cells. To examine its in vivo anti-tumor activity, we treated PC-3 tumor xenograft implanted subcutaneously in immunodeficient NU/NU (nude) mice with 1 µg/g OH-LAAO given intraperitoneally (i.p.). After 8 weeks of treatment, OH-LAAO treated PC-3 tumors were markedly inhibited, when compared to the control group (P <0.05). TUNEL staining analysis on the tumor sections showed a significantly increase of apoptotic cells in the LAAO-treated animals. Histological examinations of the vital organs in these two groups showed no significant differences with normal tissues, indicating no obvious tissue damage. The treatment also did not cause any significant changes on the body weight of the mice during the duration of the study. These observations suggest that OH-LAAO cytotoxic effects may be specific to tumor xenografts and less to normal organs. Given its potent anti-tumor activities shown in vitro as well as in vivo, the king cobra venom LAAO can potentially be developed to treat prostate cancer and other solid tumors.

Vita activa in biotechnology: what we do with fungi and what fungi do with us.

PubMed

Weinhold, Martin; Mast-Gerlach, Edeltraud; Meyer, Vera

2017-01-01

Filamentous fungi are fascinating microorganisms. One of the reasons why it is so worthwhile to take a closer look at them is their capacity to produce secondary metabolites. Some of these substances have the potential to be of great use for mankind, such as it was the case with penicillin and its discovery in 1928. Almost a century later, the situation in healthcare could possibly turn back to the state before the development of the first antibiotics. Due to an overuse of antibiotics we are facing a surge of multiresistant bacteria that are not inhibited by any of the currently known drugs. That was part of the background why a European research project was launched in October 2013, titled "Quantitative Biology for Fungal Secondary Metabolite Producers", or "QuantFung". Fifteen young scientists embarked on a new phase in their career, moving to new work environments within Europe and dedicating their work lives intensively to the quest for useful secondary metabolites. After 4 years, the QuantFung project concluded in October this year. In this commentary, we aim to convey what it means to work in this field of fungal biotechnology and how important it is to improve the efficiency of the research therein. We introduce five out of the fifteen fellows at length and let them have their say about the adventure of science, euphoric moments, prospects and doubts. We also raise questions about the current state of research in academia, something the QuantFung fellows experienced first-hand. Being a scientist often goes beyond earning money to make one's living. This is why we also reflect on aspects of the meaning of work in our western society, where production for profit's sake is a main driver. For that we refer to one of the most distinguished thinkers of the twentieth century, to Hannah Arendt.

Forest Microclimate Characteristics Review

DTIC Science & Technology

2014-09-01

Co ns tr uc tio n En gi ne er in g R es ea rc h La bo ra to ry Rosemary Keane, Hannah Pitstick, Patrick J . Guertin, and Dick L. Gebhart...Annotated Bibliography Rosemary Keane, Hannah Pitstick, Patrick J . Guertin, and Dick L. Gebhart Construction Engineering Research Laboratory U.S. Army...alphabetical order by last name of the study’s first author. Anno - tations for these references are presented in Chapter 4. Hyperlinked page numbers and

Witnessing the art of woman--centred care by an exceptional mentor.

PubMed

Lake, Joanna

2014-09-01

Using Gibb's (1998) reflective cycle, I have reflected on an experience I had as a first year student midwife working in the community setting. I met Hannah (name changed in accordance with the Nursing and Midwifery Council (NMC) (2008) guidelines relating to confidentiality) on several occasions and found that she had a great relationship with my midwife-mentor, despite her wishes falling outside of trust guidance and her feeling pressurised, by some, not to have a home birth. I analysed the relationship between Hannah and my midwife-mentor using three pairs of concepts that Lundgren and Berg (2007) considered to be essential for building sustainable, mutually-productive relationships between women and midwives: differenceness--support uniqueness; trust--mediation of trust; and participation--mutuality. I concluded that mimicking and adopting many of my mentor's characteristics, as shown in her relationship with Hannah, would benefit me and the women in my care.

Thinking critically about the occurrence of widespread participation in poor nursing care.

PubMed

Roberts, Marc; Ion, Robin

2015-04-01

A discussion of how Arendt's work can be productively re-contextualized to provide a critical analysis of the occurrence of widespread participation in poor nursing care and what the implications of this are for the providers of nursing education. While the recent participation of nurses in healthcare failings, such as that detailed in the Francis report, has been universally condemned, there has been an absence of critical analyses in the literature that attempt to understand the occurrence of such widespread participation in poor nursing care. This is a significant omission in so far as such analyses will form an integral part of the strategy to limit the occurrence of such widespread participation of nurses in future healthcare failings. Discussion paper. Arendt's 'Eichmann in Jerusalem: A Report on the Banality of Evil' and 'Thinking and Moral Considerations: A Lecture'. In addition, a literature search was conducted and articles published in English relating to the terms care, compassion, ethics, judgement and thinking between 2004-2014 were included. It is anticipated that this discussion will stimulate further critical debate about the role of Arendt's work for an understanding of the occurrence of poor nursing care, and encouraging additional detailed analyses of the widespread participation of nurses in healthcare failings more generally. This article provides a challenging analysis of the widespread participation of nurses in poor care and discusses the opportunities confronting the providers of nursing education in limiting future healthcare failings. © 2014 John Wiley & Sons Ltd.

Measurement analysis and quantum gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albers, Mark; Kiefer, Claus; Reginatto, Marcel

2008-09-15

We consider the question of whether consistency arguments based on measurement theory show that the gravitational field must be quantized. Motivated by the argument of Eppley and Hannah, we apply a DeWitt-type measurement analysis to a coupled system that consists of a gravitational wave interacting with a mass cube. We also review the arguments of Eppley and Hannah and of DeWitt, and investigate a second model in which a gravitational wave interacts with a quantized scalar field. We argue that one cannot conclude from the existing gedanken experiments that gravity has to be quantized. Despite the many physical arguments whichmore » speak in favor of a quantum theory of gravity, it appears that the justification for such a theory must be based on empirical tests and does not follow from logical arguments alone.« less

Developing the Practising Model in Physical Education: An Expository Outline Focusing on Movement Capability

ERIC Educational Resources Information Center

Barker, D. M.; Aggerholm, K.; Standal, O.; Larsson, H.

2018-01-01

Background: Physical educators currently have a number of pedagogical (or curricular) models at their disposal. While existing models have been well-received in educational contexts, these models seek to extend students' capacities within a limited number of "human activities" (Arendt, 1958). The activity of "human practising,"…

The Evolution of Human Rights in the Age of Biotechnology.

ERIC Educational Resources Information Center

Ryan, John Paul; Hron, Benjamin

1999-01-01

Examines some of the main issues and developments within biotechnology that legislators must address. Suggests how these can be utilized in the social studies classroom. Includes three articles by Hilary Glazer and Hannah Letterman, Elizabeth M. Yang, and Ami S. Jaeger. (CMK)

Occupation emerges in the process of therapy.

PubMed

Price, Pollie; Miner, Stephanie

2007-01-01

The current literature offers no cohesive definition of occupation-based practice. Current definitions emphasize intervention forms and contexts, which do not reflect the complexity of practice. This article demonstrates that the therapeutic relationship and the meanings that are created in the therapy process are central aspects of occupation-based practice. Occupation, as an idea that emerges in the therapeutic process, has aspects of both doing and becoming. The authors conducted observation sessions and interviews with an occupational therapist, Nancy, who used multiple therapeutic strategies with one child, Hannah, as they worked toward Hannah's goals of going to preschool and becoming a friend. Strategies include changing therapeutic conditions, using cognitive strategies, bridging the person-task-social context, pushing participation, and engaging in narrative micronegotiations. Occupation emerged in the therapeutic processes as the occupational therapist and client co-created meaning about the client moving toward or away from who she wanted to become.

Teaching Beginning Teachers to "Think What We Are Doing" in Indigenous Education

ERIC Educational Resources Information Center

Kameniar, Barbara; Windsor, Sally; Sifa, Sue

2014-01-01

Working with beginning teachers to assist them to begin to "think what we do" (Arendt, 1998) in both mainstream and Indigenous education is problematic. This is particularly so because the majority of our teacher candidates, and indeed most of their university lecturers, are positioned close to the racial, social and cultural centre of…

Resident perspectives of the open space conservation subdivision in Hamburg Township, Michigan

Treesearch

Maureen E. Austin

2004-01-01

The open space conservation subdivision (R.G. Arendt, 1996) has been presented as an alternative to conventional large lot residential development. A form of clustering, this planning approach emphasizes the quality as well as the quantity of land preserved. The format offers a means for local planning officials to accommodate residential growth while preserving...

Disability and Inclusive Education in Times of Austerity

ERIC Educational Resources Information Center

Veck, Wayne

2014-01-01

When communities fall into decline, disabled people can find themselves alone and invisible in a society of indifferent individuals. Arendt offers an account of such a time in her discussion of the rise of a society of mass labouring and consuming. Bauman's insights into the fragmentation of life, in which established norms, traditional ties and…

Scalable Topic Modeling: Online Learning, Diagnostics, and Recommendation

DTIC Science & Technology

2017-03-01

Chinese restaurant processes. Journal of Machine Learning Research, 12:2461–2488, 2011. 15. L. Hannah, D. Blei and W. Powell. Dirichlet process mixtures of...34. S. Ghosh, A. Ungureanu, E. Sudderth, and D. Blei. A Spatial distance dependent Chinese restaurant process for image segmentation. In Neural

Learning from "Escuela": Documentary Film as a Context for Teacher Learning

ERIC Educational Resources Information Center

Khasnabis, Debi; Goldin, Simona

2016-01-01

This article reports on the design of a teacher education activity that involves the documentary film, "Escuela," which was produced by Hannah Weyer. We describe this instructional design, highlighting how documentary film can be used strategically to create opportunities for teacher candidates to approximate the work of culturally…

Aesthetic Relationships and Ethics in "The Oh Fuck Moment"

ERIC Educational Resources Information Center

Breel, Astrid

2015-01-01

This article explores the aesthetics and ethics of participatory performance through "The Oh Fuck Moment" by Hannah Jane Walker and Chris Thorpe, a performance that aesthetically explores ethically troubling material and manipulation. Ethical criticism of participatory art in recent years has focused on the way the audience member is…

Tectonic controls on magmatism in the Geysers-Clear Lake region: Evidence from new geophysical models

USGS Publications Warehouse

Stanley, W.D.; Benz, H.M.; Walters, M.A.; Villasenor, A.; Rodriguez, B.D.

1998-01-01

In order to study magmatism and geothermal systems in The Geysers-Clear Lake region, we developed a detailed three-dimensional tomographic velocity model based on local earthquakes. This high-resolution model resolves the velocity structure of the crust in the region to depths of approximately 12 km. The most significant velocity contrasts in The Geysers-Clear Lake region occur in the steam production area, where high velocities are associated with a Quaternary granitic pluton, and in the Mount Hannah region, where low velocities occur in a 5-km-thick section of Mesozoic argillites. In addition, a more regional tomographic model was developed using traveltimes from earthquakes covering most of northern California. This regional model sampled the whole crust, but at a lower resolution than the local model. The regional model outlines low velocities at depths of 8-12 km in The Geysers-Clear Lake area, which extend eastward to the Coast Range thrust. These low velocities are inferred to be related to unmetamorphosed Mesozoic sedimentary rocks. In addition, the regional velocity model indicates high velocities in the lower crust beneath the Clear Lake volcanic field, which we interpret to be associated with mafic underplating. No large silicic magma chamber is noted in either the local or regional tomographic models. A three-dimensional gravity model also has been developed in the area of the tomographic imaging. Our gravity model demonstrates that all density contrasts can be accounted for in the upper 5-7 km of the crust. Two-dimensional magnetotelluric models of data from a regional, east-west profile indicate high resistivities associated with the granitic pluton in The Geysers production area and low resistivities in the low-velocity section of Mesozoic argillites near Mount Hannah. No indication of midcrustal magma bodies is present in the magnetotelluric data. On the basis of heat flow and geologic evidence, Holocene intrusive activity is thought to have

Serving My Family.

ERIC Educational Resources Information Center

Reclaiming Children and Youth, 2001

2001-01-01

The recipient of the year 2000 Kellogg's Hannah Neil World of Children Award was Father William Wasson, founder of Neustros Pequenos Hermanos [NPH], a network of orphanages in Mexico and Latin America. Since its beginning in 1953 the entire fabric of NPH is woven around the ethic of service. (Author)

Why Are You Wearing a Watch? Complicating the Narrative of Economic and Social Progress in Britain with Year 9

ERIC Educational Resources Information Center

Sibona, Hannah

2017-01-01

Frustrated by the traditional narrative of the industrial revolution as a steady march of progress, and disappointed by her students' dull and deterministic statements about historical change, Hannah Sibona decided to complicate the tidy narrative of continual improvement. Inspired by an article by E.P. Thompson, Sibona reflected that introducing…

"Sad, Just Sad": A Woman with a Learning Disability Experiencing Bereavement

ERIC Educational Resources Information Center

Campbell, Alison; Bell, Dorothy

2011-01-01

This case study considers the psychological assessment, formulation and treatment of Hannah, a woman with a learning disability who recently experienced the death of her mother. Death still remains a challenging and often taboo subject. Moreover, when the grief is of a person with a learning disability, this combines with underlying difficulties…

Building Relationships Step by Step: One Teacher Leader's Journey

ERIC Educational Resources Information Center

Mangin, Melinda M.

2010-01-01

This case describes how Hannah, a new math specialist, strives to create a positive math culture in her elementary school. Along the way, she works to build relationships with the teachers and the school principal. The accompanying teaching notes facilitate analysis of the case from the perspective of professional relationships in schools.

"Everything...Affects Everything": Promoting Critical Perspectives toward Bullying with "Thirteen Reasons Why"

ERIC Educational Resources Information Center

Chisholm, James S.; Trent, Brandie

2012-01-01

"Everything...affects everything," from Jay Asher's young adult novel, "Thirteen Reasons Why," captures a central message of this text in which a young woman named Hannah Baker leaves behind a series of tapes addressed to particular individuals who played a part in producing the snowball effect that led to her suicide. "Everything...affects…

The Psychophysics of Contingency Assessment

ERIC Educational Resources Information Center

Allan, Lorraine G.; Hannah, Samuel D.; Crump, Matthew J. C.; Siegel, Shepard

2008-01-01

The authors previously described a procedure that permits rapid, multiple within-participant evaluations of contingency assessment (the "streamed-trial" procedure, M. J. C. Crump, S. D. Hannah, L. G. Allan, & L. K. Hord, 2007). In the present experiments, they used the streamed-trial procedure, combined with the method of constant stimuli and a…

Schneider Comment on Downey and Condron

ERIC Educational Resources Information Center

Schneider, Barbara

2016-01-01

Barbara Schneider is the John A. Hannah Chair and University Distinguished Professor in the College of Education and Department of Sociology at Michigan State University. Her research focuses on how the social contexts of schools and families influence the academic and social well being of adolescents as they move into adulthood. In this article…

The Twenty-Third Dudley Allen Sargent Commemorative Lecture 2003: Knowledge and Physical Activity in Higher Education

ERIC Educational Resources Information Center

Estes, Steven G.

2003-01-01

In preparation for this lecture, the author read, among other studies, previous Sargent, Homans, and Hannah lectures. These papers read well, and, they continue to inform people today. Importantly, these lecturers addressed timely issues that confronted physical education in higher education and to some extent shaped the field as one now knows it.…

Medieval Iceland, Greenland, and the New Human Condition: A case study in integrated environmental humanities

NASA Astrophysics Data System (ADS)

Hartman, Steven; Ogilvie, A. E. J.; Ingimundarson, Jón Haukur; Dugmore, A. J.; Hambrecht, George; McGovern, T. H.

2017-09-01

This paper contributes to recent studies exploring the longue durée of human impacts on island landscapes, the impacts of climate and other environmental changes on human communities, and the interaction of human societies and their environments at different spatial and temporal scales. In particular, the paper addresses Iceland during the medieval period (with a secondary, comparative focus on Norse Greenland) and discusses episodes where environmental and climatic changes have appeared to cross key thresholds for agricultural productivity. The paper draws upon international, interdisciplinary research in the North Atlantic region led by the North Atlantic Biocultural Organization (NABO) and the Nordic Network for Interdisciplinary Environmental Studies (NIES) in the Circumpolar Networks program of the Integrated History and Future of People on Earth (IHOPE). By interlinking analyses of historically grounded literature with archaeological studies and environmental science, valuable new perspectives can emerge on how these past societies may have understood and coped with such impacts. As climate and other environmental changes do not operate in isolation, vulnerabilities created by socioeconomic factors also beg consideration. The paper illustrates the benefits of an integrated environmental-studies approach that draws on data, methodologies and analytical tools of environmental humanities, social sciences, and geosciences to better understand long-term human ecodynamics and changing human-landscape-environment interactions through time. One key goal is to apply previously unused data and concerted expertise to illuminate human responses to past changes; a secondary aim is to consider how lessons derived from these cases may be applicable to environmental threats and socioecological risks in the future, especially as understood in light of the New Human Condition, the concept transposed from Hannah Arendt's influential framing of the human condition that is

The Effects of Melatonin on Menstrual Characteristics, Prolactin and Premenstrual Syndrome-Like Symptoms During a Simulated Eastward Deployment

DTIC Science & Technology

1998-06-01

shown to Tesynchronize circadian rhythms and induce sleep in humans (Arendt et al.51987; Dawson and Encel, 1993; Reiter, 1991; Wurtman, 1986), is...melatonin levels, in women experiencing amenorrhea , are more than double the normal levels observed in cycling women (Berga et al., 1988; Brzezinski...associated with the induction of amenorrhea . In females with normal menstrual cycles, a tenuous relationship between endogenous melatonin and basal LH has

Flux Pinning in YBa2Cu3O7-delta Thin Film Samples Linked to Stacking Fault Density (Postprint)

DTIC Science & Technology

2008-10-01

Driscoll, S. R. Foltyn, Q. X. Jia, H. Wang, A. Serquis, B. Maiorov, L. Civale, Y. Lin, M. E. Hawley , M. P. Maley, and D. E. Peter- son, Appl. Phys. Lett. 84...Civale, B. Maiorov, A. Serquis, J. O. Willis , J. Y. Coulter, H. Wang, Q. X. Jia, P. N. Arendt, J. L. MacManus-Driscoll, M. P. Maley, and S. R. Foltyn, Appl

New Teachers Search for Place in New Orleans

ERIC Educational Resources Information Center

Zubrzycki, Jaclyn

2013-01-01

Derek Roguski and Hannah Sadtler came to New Orleans in 2008 through Teach For America. The competitive program provided five weeks' training and helped place them in schools, and both young teachers were eager to learn to teach and help the city's students. But they quickly found that they had more questions than answers about the schools they…

Outdoor Learning Can Help Children Flourish in Science and across the Curriculum--The FSC Takes a Lead

ERIC Educational Resources Information Center

Rose, Hannah; Kempton, Anneke

2014-01-01

The recent explosive growth of the Wild Network, which exists to champion and support connection with nature and wildness in children and young people, suggests that there is a groundswell of support for getting young people outdoors. Hannah Rose and Anneke Kempton of the Field Studies Council (FSC) explain why the outdoors is such an important…

New To Teaching: "Vegecating" Children

ERIC Educational Resources Information Center

Bagshaw, Katherine; Barham, Hannah; Betts, Rebecca; Felton, Amie; Knatt, Joshua

2014-01-01

Student teachers, Katherine Bagshaw, Hannah Barham, Rebecca Betts, Amie Felton and Joshua Knatt, share their ideas on how to bridge the gap between statutory and non-statutory guidelines for food and nutrition with 8- to 10-year-olds. The teachers realized the health of children has become a focal point of concern for both parents and education…

Print Literacy: A Teacher's Story. Early Literacy and Assessment for Learning (K-3) Series

ERIC Educational Resources Information Center

Pacific Resources for Education and Learning (PREL), 2004

2004-01-01

Hannah is a Pacific island grade 1 teacher in a local village school. She has been guided in her teaching practice by the values she learned growing up in an extended family. These values involved observing and listening to elders, and then practicing what she observed and participating in many conversations among family members. Written by the…

Effect of Aggressive Environments on Mechanical Performance of Fibre Ceramic Composites

DTIC Science & Technology

2007-07-01

the ends. The ASTM standard test method for tensile properties of fibre–resin composites has the designation D3039-76. It recommends that the...Arendts, F.J., Theuer, A., Maile, K., Kuhnle, J., Neuer, G., Brandt, R., Thermomechanical and Thermophysical properties of liquid Siliconized C/C...atmosphere by the flame of oxy-acetylene gas. The changes in microhardness, XRD pattern and thermal properties are appeared because of delamination

Team Dimensions: Their Identity, Their Measurement and Their Relationships

DTIC Science & Technology

1985-01-01

business games (e.g., Cummings, Huber & Arendt, 1974; Kennedy, 1971 ). Apart from the problem solving tasks, the second largest group of studies...positive relationship between size and number of answers on. an anagram task. In a disjunctive problem, solving-task-, Frank & Anderson ( 1971 ) found that...4, or 5 members. However, there were no differences between the groups in time to solutions. Goldman ( 1971 ) found posi’tive effects for size with

Gender, British Administration and Mission Management of Education in Zambia 1900-1939

ERIC Educational Resources Information Center

Allen, Julia

2010-01-01

This article discusses the impact of including gender in the analytical framework in a study of the management and provision of education in Zambia from 1900 to 1939. It shows that a focus on gender allows females to enter the historical narrative and the leadership of women such as Mabel Shaw, Hannah Frances Davidson and Julia Smith can be given…

27 CFR 9.99 - Clear Lake.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Mt. Hannah in Section 16, Township 12 North (T12N), Range 8 West (R8W), identified as having an... Seigler Mountain in Section 23, T12N/R8W, identified as having an elevation of 3,692 feet; (2) Then east... the top of Round Mountain (8) Then northwesterly in a straight line to the southeast corner of Section...

27 CFR 9.99 - Clear Lake.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Mt. Hannah in Section 16, Township 12 North (T12N), Range 8 West (R8W), identified as having an... Seigler Mountain in Section 23, T12N/R8W, identified as having an elevation of 3,692 feet; (2) Then east... the top of Round Mountain (8) Then northwesterly in a straight line to the southeast corner of Section...

27 CFR 9.99 - Clear Lake.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Mt. Hannah in Section 16, Township 12 North (T12N), Range 8 West (R8W), identified as having an... Seigler Mountain in Section 23, T12N/R8W, identified as having an elevation of 3,692 feet; (2) Then east... the top of Round Mountain (8) Then northwesterly in a straight line to the southeast corner of Section...

27 CFR 9.99 - Clear Lake.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Mt. Hannah in Section 16, Township 12 North (T12N), Range 8 West (R8W), identified as having an... Seigler Mountain in Section 23, T12N/R8W, identified as having an elevation of 3,692 feet; (2) Then east... the top of Round Mountain (8) Then northwesterly in a straight line to the southeast corner of Section...

27 CFR 9.99 - Clear Lake.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Mt. Hannah in Section 16, Township 12 North (T12N), Range 8 West (R8W), identified as having an... Seigler Mountain in Section 23, T12N/R8W, identified as having an elevation of 3,692 feet; (2) Then east... the top of Round Mountain (8) Then northwesterly in a straight line to the southeast corner of Section...

Implicit Personality and Leadership in Stressful and Dangerous Situations: A First Step

DTIC Science & Technology

2012-05-01

psychological interpretation. New York: Holt. Aspelmeier, J . E., & Pierce, T . W. (2009). SPSS: A user friendly approach. New York, NY: Worth...Occupational and Organizational Psychology, 72, 441- 462. Avolio, B. J ., & Hannah, S. T . (2008). Developmental readiness: Accelerating leader development...Nonconscious activation and pursuit of behavioral goals. Journal of Personality and Social Psychology, 81(6), 1014-1027. Bargh, J . A., & Chartrand, T

Time Critical Conventional Strike from Strategic Standoff

DTIC Science & Technology

2009-03-01

Competitor with Emerging Counter-Space Capability has Destroyed U.S. Leo Satellite...destroyed a U.S. Low Earth Orbit ( LEO ) satellite. The U.S. desires to prevent future damage to other satellites in the constellation, but with...Precision from ISR Assets January 18 – 19 2007 Col Paul Gydesen USAF USAF ICBM, Ballistic Missile – Prompt Global Strike Dr. Barry Hannah Navy

New host and locality records of snake intestinal nematode Kalicephalus spp in Indonesia

PubMed Central

Purwaningsih, Endang; Mumpuni

2011-01-01

Objective To observe three species of Kalicephalus found in three species of snake (Ophiophagus hannah, Ptyas mucosus, and Naja Sputatrix) during research on Capture Snake for Trading in Java and Snake Biodiversity in Kalimantan Islands. Methods Specimens for light microscopy examination were fixed with warm 70% alcohol, cleared and mounted in lactophenol for wet mounting. Drawings were made with the aid of a drawing tube attached to a Nikon compound microscope. Measurements were given in micrometers (µ) as the average of findings, followed by the range in parentheses, unless otherwise stated. Results Kalicephalus (Costatus) indicus was found from 7 Ptyas mucosus, Kalicephalus bungari from 2 Naja sputatrix and 1 Kalicephalus (Costatus) indicus and Kalicephalus assimilis found from 1 Ophiophagus hannah. The morphology and measurement of three species of Kalicephalus found in this study were close to those described before. Conclusions New finding of host of Kalicephalus (Costatus) indicus and Kalicephalus bungari was a snake species of Naja sputatrix. New records of locality were Kalimantan island as the new locality of Kalicephalus assimilis, and Java island was new locality of Kalicephalus (Costatus) indicus. PMID:23569740

Phospholipase a properties of several snake venom preparations.

PubMed

Nutter, L J; Privett, O S

1966-07-01

The hydrolytic properties of the venoms of seven species of snakes,Crotalus adamanteus, Ancistrodon contortrix, Naja naja, Bothrops atrox, Ophiophagus hannah, Crotalus atrox andVipera russeli, were studied with purified lecithins and mixtures of lecithins of known fatty acid and class composition as substrates.The relative rates of hydrolysis of the fatty acids by the above venoms were studied by analysis of the products of the reaction at intervals during the course of the reaction. Of the seven venoms studied, that ofOphiophagus hannah was the only one which did not give some degree of preferential rate of hydrolysis of individual fatty acids.In general, saturated fatty acids were liberated faster than unsaturated fatty acids; differences in the rates of the hydrolysis of individual saturate and unsaturated fatty acids were also observed. Individual classes of lecithin were also hydrolyzed at different rates. For the determination of the distribution of the fatty acids between the alpha- and beta-position of lecithin, the reaction should be carried to completion. If the reaction requires a prolonged time to go to completion, it should be carried out under nitrogen to prevent autoxidation.

Acute and Delayed Effects of Melatonin: Operational Significance

DTIC Science & Technology

2000-03-01

In mammals its primary sites circadian zeitgeber in humans have been much of production are the pineal gland and the retina, discussed (e.g. 5...proposed as an methoxytryptamine (melatonin). The rhythm of endogenous sleep substance, as an opener of the pineal synthesis is generated in the...melatonin in the blind. J Biol Rhythms 1996; 12:16-25. References 1. Arendt J. Melatonin and the manmmalian pineal 14. Sack R L, Lewy AJ, Blood ML

Flux Pinning Enhancement in YBa2Cu3O7-x Films for Coated Conductor Applications (Postprint)

DTIC Science & Technology

2010-01-01

YBa2Cu3O7–x Films for Coated Conductor Applications Maiorov , B. , Civale , L. , Lin , Y. , Hawley , M.E. , Maley , M.P. , and Peterson , D.E...L. , Maiorov , B. , Hawley , M.E. , Maley , M.P. , and Peterson , D.E. ( 2004 ) Nat. Mater. , 3 , 439 . 30 Kang , S. , Goyal...1864 . 47 Civale , L. , Maiorov , B. , Serquis , A. , Willis , J.O. , Coulter , J.Y. , Wang , H. , Jia , Q.X. , Arendt , P.N

Eurasianism: A Historical and Contemporary Context

DTIC Science & Technology

2015-03-01

Foreign Affairs, March 31, 2014, http://www.foreignaffairs.com/articles/141080/anton-barbashin-and-hannah-thoburn/putins-brain. 2 Dina Newman , “Russian...Eurasianism: An Ideology of Empire (Baltimore: Johns Hopkins Press, 2008), trans. Mischa Gabowitsch, 142. 4 Dina Newman , “Russian Nationalist...Russian Eurasiansim – Historiosophy and Ideology,” 106. 17 his parents were renowned poets) and as such, he faced difficulty in gaining

Selection and Effects of Channels in Distributed Communication and Decision-Making Tasks: A Theoretical Review and a Proposed Research Paradigm

DTIC Science & Technology

1988-04-01

in speaking, writing, and oral literture. In Deborah Tannen (Ed.) Spoken and written lanquage: Exploring orality and literacy. Norwood, NJ: Ablex...strategies. Cambridge: Cambridge .’. University Press. Gumperz, John J., Tannen , Deborah . (1978). Individual and social differences in lanquaqe use. In W. Wang...Hannah, & O’Connor, Mary Catherine. (1984). Cohesion in spoken and written discourse: Ethnic style and the transition to literacy. In Deborah Tannen (Ed

Merced County Streams Project, Burns Reservoir, California Intensive Cultural Resources Survey.

DTIC Science & Technology

1981-01-01

Larry McKee, and Melinda Peak; and to the technicians: Barry Boyer, Herb Dallas, Hannah Gibbs, Stuart Guedon, Sherri Gust, Les Harville, Paul...Subsistence was based on the acorn and supplemented by gathering of seeds, berries, greens, nuts, and edible roots. Fish, game, and small mammals...the continent to witness. Large troops of wild horses, many deer, antelope, and coyotes were-constantly on view (Keyes 1884:234). The horses had been

The X-ray Halo of GX5-1

NASA Technical Reports Server (NTRS)

Smith, Randall K.; Dame, T. M.; Costantini, Elisa; Predehl, Peter

2006-01-01

Using Chandra observations we have measured the energy-resolved dust-scattered X-ray halo around the low-mass X-ray binary GX5-1, detecting for the first time multiply scattered X-rays from interstellar dust. % e compared the observed X-ray halo at various energies to predictions from a range of dust models. These fits used both smoothly-distributed dust as well as dust in clumped clouds, with CO and 21 cm observations helping to determine the position of the clouds along the line of sight. We found that the BARE-GR-B model of Zubko, Dwek & Arendt (2004) generally led to the best results, although inadequacies in both the overall model and the data limit our conclusions. We did find that the composite dust models of Zubko, Dwek & Arendt (2004), especially the "no carbon" models, gave uniformly poor results. Although models using cloud positions and densities derived naively from CO and 21 cm data gave generally poor results, plausible adjustments to the distance of the largest cloud and the mass of a cloud in the expanding 3 kpc Arm lead to significantly improved fits. We suggest that combining X-ray halo, CO, and 21 cm observations will be a fruitful method to improve our understanding of both the gas and dust phases of the interstellar medium.

Understanding and Action: Thinking with Arendt about Democratic Education

ERIC Educational Resources Information Center

Lange, Lis

2012-01-01

Taking as its point of departure Ahier's location of the problem of citizenship in the context of the changes that globalisation and neo-liberalism have brought about in higher education, this article focuses on the conceptual preconditions that need to underpin the idea of "teaching" citizenship through the university curriculum. The…

Survey of Technology with Possible Applications to United States Coast Guard Buoy Tenders. Volume 2. Literature Abstracts.

DTIC Science & Technology

1987-09-01

WORK VESSELS TECHNICAL AND OVERVIEW ARTICLES Arendt, John W., "A Specialty Item (The anchor-handling tug on the marine pipeline)", Fourth International...yard. Marier, John B. "What’s Ahead in Shallow Water Seismic Vessel Design", Ocean Industry, June 1983, (’Digicon Definition’) "Marine Fabricators...paper indicated that such a system would out-perform bilge keels by a substantial margin, while costing 20% less. A-32 Lewison , G.R.G., "Optimum Design of

Aquatic Plant Control Research Program. A Survey of the Continental United States for Pathogens of Eurasian Watermilfoil

DTIC Science & Technology

1988-04-01

Res. Old boat basin Chelan 13 Sep 1984 Rock Island Res. Mouth of Wenatchee River Chelan 13 Sep 1984 Rock Island Res. Hannah Mining Co. Douglas 13 Sep...States, including ponds, lakes, reser- voirs, rivers , and canals. At the conclusion of the survey, 792 isolates had been collected from tissue samples...acre (9-ha) pond located in Anne Arundel County, Maryland, and an area near the Northeast River in Cecil County, Maryland--and suggested the declines

Kommunale Energieversorger als wesentliche Akteure der Digitalisierung - Strategien und Handlungsoptionen

NASA Astrophysics Data System (ADS)

Reiche, Katherina

Die Digitalisierung erfasst sämtliche Bereiche des Lebens und Wirtschaftens. Auch die Kommunalwirtschaft - insbesondere die kommunale Energiewirtschaft - sieht sich perspektivisch disruptiven Entwicklungen gegenüber. Stadtwerke haben bereits viele Herausforderungen erfolgreich gemeistert und stehen auch der Digitalisierung positiv gegenüber. Vielerorts gestalten kommunale Unternehmen den digitalen Wandel bereits aktiv mit. Dieser Artikel arbeitet die Assets kommunaler Unternehmen heraus und zeigt Strategien und Handlungsoptionen zum Umgang mit der digitalen Transformation für kommunale Energieversorgungsunternehmen auf. Dabei zeigt sich, dass das politische und regulatorische Umfeld für das positive Gelingen der Digitalisierung entscheidend sind. Kommunale Unternehmen benötigen die gleichen Marktzugangsbedingungen wie andere Akteure. Ferner profitieren kommunale Unternehmen von einigen Wettbewerbsvorteilen, etwa hohen Vertrauenswerten ihrer Kunden und umfangreiches Know-how im Datenmanagement.

S2k-Leitlinie zum Gebrauch von Präparationen zur lokalen Anwendung auf der Haut (Topika).

PubMed

Wohlrab, Johannes; Staubach, Petra; Augustin, Matthias; Eisert, Lisa; Hünerbein, Andreas; Nast, Alexander; Reimann, Holger; Strömer, Klaus; Mahler, Vera

2018-03-01

Diese Leitlinie richtet sich an Assistenz- und Fachärzte der Dermatologie sowie an Kostenträger und politische Entscheidungsgremien. Die Leitlinie wurde im formellen Konsensusverfahren (S2k) von Dermatologen unter Einbindung von Apothekern erstellt. Die Leitlinie stellt allgemeine Aspekte der Pharmakokinetik sowie der regulatorischen Begrifflichkeiten dar. Es werden Empfehlungen zur Indikation von Magistralrezepturen sowie deren Qualitätssicherung gegeben. Die Bedeutung der galenischen Grundlagen und die Problematik bei einer Substitution gegeneinander verschiedener Grundlagen werden dargestellt. Die Leitlinie umfasst Kriterien zur Auswahl einer adäquaten Grundlage sowie spezifische Aspekte zur Therapieplanung. Die Leitlinie gibt Empfehlungen zum Management bei Unverträglichkeiten gegenüber Bestandteilen der Grundlagen oder Hilfsstoffe. © 2018 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

Effects of the Variable Lorentz Force on the Critical Current in Anisotropic Superconducting Thin Films (Postprint)

DTIC Science & Technology

2007-06-01

Phys. Lett., vol. 87, p. 162505, 2005. [2] J. L. Macmanus-Driscoll, S. R. Foltyn, Q. X. Jia, H. Wang, A. Serquis, L. Civale, B. Maiorov, M. E. Hawley ...B. Maiorov, L. Civale, Y. Lin, M. E. Hawley , M. P. Maley, and D. E. Peterson, “Systematic enhancement of in-field critical current density with rare...16, p. 162 507–1, 2005. [15] H. Safar, J. Y. Coulter, M. P. Maley, S. R. Foltyn, P. N. Arendt, X. D. Wu, and J. O. Willis , “Anisotropy and Lorentz

The Surface Microlayer: Review of Literature and Evaluation of Potential Effects of Dredge Activities in Puget Sound.

DTIC Science & Technology

1987-01-01

Heyrand. 1975. Polonium - 210 - Its vertical oceanic transport by zoo- plankton metabolic activity. Marine Chemistry 3:105-110. Collins, J. 1974. Oil and...Toxicology Environ. Health 7:991-1000. Hose, J.E., J.B. Hannah, D. Dijulio, M.L. Landolt, B.S. Miller, W.T. Iwaoka, and S.P. Felton. 1982. Effects of benzo(a...A184 885 THE SURFACE MICROLAVER, REVIEWJ OF LITERATURE AND 1/2 EVALUATION OF POTENTIAL EFFECTS OF DREDGE ACTIVITIES IN PUGET SOUND(U) EVANS-HAMILTON

Deceased Slabs Drive Oil

NASA Astrophysics Data System (ADS)

Stein, H. J.; Hannah, J. L.

2017-12-01

The application of Re-Os isotope geochemistry to dating single oils is a nascent field [1,2]. Challenges include dissection of oils into asphaltene-maltene (ASPH-MALT) components in a way that preserves meaningful chronologic and source information. Significantly, oil-water mixing rapidly transfers Os to the oil, while Re exchange is sluggish [3]. The Os initial ratio of the oil is shifted in the direction of Os carried in the aqueous fluid, whereas the Re-Os isotopic age is preserved. We show that this phenomenon is operative in natural systems. Further, we show that deserpentinization of old oceanic slabs [4], may be linked to expulsion of Os-enriched waters into overlying sedimentary sections - a process that may be of fundamental importance for oil generation. This conclusion does not diminish the role of traditional organic-rich shales as source rocks for the hydrocarbon, but shows that external fluids are essential to petroleum generation. Moreover, the external fluids may be an important driver for expulsion and migration of oils. We have taken apart several petroleum systems from source rock, to residual oil, to tar mat development, to in situ live oil, through to produced oil. In many cases, a fluid with low 187Os/188Os - unlike that of normal basinal brines - provides a critical component to the oil-water mixture. Funding - CHRONOS project supported by Norwegian petroleum industry (Eni-Norge, Lundin, Aker BP) Acknowledgement - Christine Fichler [4], who first queried us on old slabs and oil, and stimulated ideas. [1] Georgiev, S.V., Stein, H.J., Hannah, J.L., Galimberti, R., Nali, M., Yang, G., and Zimmerman, A. (2016) Re-Os dating of maltenes and asphaltenes within single samples of crude oil: Geochim. Cosmochim. Acta 179: 53-75. [doi.org/10.1016/j.gca.2016.01.016] [2] DiMarzio, J., Georgiev, S.V., Stein, H.J., and Hannah, J.L. (in press) Residency of rhenium and osmium in a heavy crude oil: Geochim. Cosmochim. Acta. [3] Hurtig, N.C., Georgiev, S

Psychophysics of associative learning: Quantitative properties of subjective contingency.

PubMed

Maia, Susana; Lefèvre, Françoise; Jozefowiez, Jérémie

2018-01-01

Allan and collaborators (Allan, Hannah, Crump, & Siegel, 2008; Allan, Siegel, & Tangen, 2005; Siegel, Allan, Hannah, & Crump, 2009) recently proposed to apply signal detection theory to the analysis of contingency judgment tasks. When exposed to a flow of stimuli, participants are asked to judge whether there is a contingent relation between a cue and an outcome, that is, whether the subjective cue-outcome contingency exceeds a decision threshold. In this context, we tested the following hypotheses regarding the relation between objective and subjective cue-outcome contingency: (a) The underlying distributions of subjective cue-outcome contingency are Gaussian; (b) The mean distribution of subjective contingency is a linear function of objective cue-outcome contingency; and (c) The variance in the distribution of subjective contingency is constant. The hypotheses were tested by combining a streamed-trial contingency assessment task with a confidence rating procedure. Participants were exposed to rapid flows of stimuli at the end of which they had to judge whether an outcome was more (Experiment 1) or less (Experiment 2) likely to appear following a cue and how sure they were of their judgment. We found that although Hypothesis A seems reasonable, Hypotheses B and C were not. Regarding Hypothesis B, participants were more sensitive to positive than to negative contingencies. Regarding Hypothesis C, the perceived cue-outcome contingency became more variable when the contingency became more positive or negative, but only to a slight extent. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

[Medical power and the crisis in bonds of trust within contemporary medicine].

PubMed

Azeredo, Yuri Nishijima; Schraiber, Lilia Blima

2016-01-01

Based on the Brazilian context, this paper addresses medical power in terms of the current conflicts in the intersubjective relationships that doctors establish in their work, conflicts considered here as a product of a crisis of trust connected to recent historical transformations in the medical practice. Reading these conflicts as questions of an ethical and moral order, we use Hanna Arendt's theoretical formulations to further analyze this crisis of trust. In this way, utilizing the concepts of "crisis," "tradition," "power," "authority," and "natality," we search for new meanings regarding these conflicts, enabling new paths and solutions that avoid nostalgia for the past.

Visiting Good Company: Arendt and the Development of the Reflective Practitioner

ERIC Educational Resources Information Center

Gillies, Donald

2016-01-01

The importance of the concept of reflective practice within the teaching profession has been stressed heavily in recent decades. How it is enacted and how beginning teachers, in particular, have been encouraged to exercise it remains somewhat unclear, with the risk that it becomes a cursory, ill-informed exercise in self-affirmation rather than a…

Mikrodaten und statistische Auswertungsmethoden

NASA Astrophysics Data System (ADS)

Hujer, Reinhard

Mit der zunehmenden Verfügbarkeit immer größerer Querschnitts- und Längschnittsdatensätze für Personen, Haushalte und Betriebe sowie deren Verknüpfungen hat sich die mikroökonometrische Forschung in den vergangenen Jahren rasant weiterentwickelt. Dies gilt sowohl aus methodischer als auch aus empirischer, anwendungsorientierter Sicht. Mikrodaten und mikroökonometrische Ansätze dienen dazu, aktuelle, politikrelevante Fragen aufzugreifen, sie zu analysieren und fundierte politische Empfehlungen zu geben, beispielsweise im Rahmen der Arbeitsmarkt- und Sozialpolitik, der Finanzanalyse und der Marketingforschung. Die Deutsche Statistische Gesellschaft (DStatG) und deren Mitglieder haben sich in den Ausschüssen und in Hauptversammlungen kontinuierlich mit den Weiterentwicklungen der mikroökonometrischen Methodik und den empirischen Anwendungen befasst. Zahlreiche Publikationen von Mitgliedern der DStatG haben entscheidend zum kritischen Diskurs und zum wissenschaftlichen Fortschritt in diesem Bereich beigetragen.

Anticipation of somatosensory and motor events increases centro-parietal functional coupling: an EEG coherence study.

PubMed

Babiloni, Claudio; Brancucci, Alfredo; Vecchio, Fabrizio; Arendt-Nielsen, Lars; Chen, Andrew C N; Rossini, Paolo M

2006-05-01

Does functional coupling of centro-parietal EEG rhythms selectively increase during the anticipation of sensorimotor events composed by somatosensory stimulation and visuomotor task? EEG data were recorded in (1) 'simultaneous' condition in which the subjects waited for somatosensory stimulation at left hand concomitant with a Go (or NoGo) visual stimulus triggering (50%) right hand movements and in (2) 'sequential' condition where the somatosensory stimulation was followed (+1.5 s) by a visuomotor Go/NoGo task. Centro-parietal functional coupling was modeled by spectral coherence. Spectral coherence was computed from Laplacian-transformed EEG data at delta-theta (2-7 Hz), alpha (8-14 Hz), beta 1 (15-21 Hz), beta 2 (22-33 Hz), and gamma (34-45 Hz) rhythms. Before 'simultaneous' sensorimotor events, centro-parietal coherence regions increased in both hemispheres and at all rhythms. In the 'sequential' condition, right centro-parietal coherence increased before somatosensory event (left hand), whereas left centro-parietal coherence increased before subsequent Go/NoGo event (right hand). Anticipation of somatosensory and visuomotor events enhances contralateral centro-parietal coupling of slow and fast EEG rhythms. Predictable somatosensory and visuomotor events are anticipated not only by synchronization of cortical pyramidal neurons generating EEG power in parietal and primary sensorimotor cortical areas (Babiloni C, Brancucci A, Capotosto P, Arendt-Nielsen L, Chen ACN, Rossini PM. Expectancy of pain is influenced by motor preparation: a high-resolution EEG study of cortical alpha rhythms. Behav. Neurosci. 2005a;119(2):503-511; Babiloni C, Brancucci A, Pizzella V, Romani G.L, Tecchio F, Torquati K, Zappasodi F, Arendt-Nielsen L, Chen ACN, Rossini PM. Contingent negative variation in the parasylvian cortex increases during expectancy of painful sensorimotor events: a magnetoencephalographic study. Behav. Neurosci. 2005b;119(2):491-502) but also by functional

Human Conditions for Teaching: The Place of Pedagogy in Arendt's "Vita Activa"

ERIC Educational Resources Information Center

Higgins, Chris

2010-01-01

Background/Context: If education centrally involves self-cultivation, and the teacher's own robust selfhood is necessary for inspiring self-cultivation in students, then teacherly self-cultivation is a necessary condition of education. But teaching is seen as a helping profession, where helping others always seems, in practice if not in principle,…

Energy as a Service

NASA Astrophysics Data System (ADS)

Pell, Wolfgang

Energie wird zum Gebrauchsgegenstand, zur Commodity und rückt doch in den Blickpunkt der Aufmerksamkeit. Volkswirtschaftliche, politische, gesellschaftliche und betriebswirtschaftliche Ansprüche lassen Services rund um die Energieversorgung (Energy-related Services) entstehen. Convenience Services, die den Ansprüchen der Konsumenten gerecht werden, wie Visualisierung von (dezentraler) Energieerzeugung und -verbrauch auf Basis digitaler Smart Meter, die den analogen Ferraris-Zähler ersetzen, sowie optimierter Energieeinsatz halten in Haushalten als digitalisierten Standorten (Smart Sites) Einzug. Energieoptimierung auf Basis des Paradigmas "Verbrauch folgt Erzeugung" stellt Nachfrageflexibilität industrieller Prozesse (Demand Response) als Energie-Effizienz-Faktor in den Vordergrund und lässt Services wie ihre Vermarktung als Regelenergie zur Stabilisierung der Netzfrequenz entstehen. Ein Innovation Action Plan liefert einen Ausblick, wohin die Integration neuer Technologien, die Steigerung der Kundennähe und die Entwicklung neuer Geschäftsmodelle die Energiewirtschaft führen kann. Mit Eco-Home und Power-Pool werden zwei konkrete Beispiele für Energy as a Service vorgestellt.

Earth observations of Hudson Bay, Canada taken from OV-105 during STS-99

NASA Image and Video Library

2000-03-14

STS099-706-090 (11-22 February 2000) ---One of the astronauts aboard the Space Shuttle Endeavour for the STS-99 mission recorded this 70mm image of Hannah Bay, in the southern part of St. James Bay. The river is the Harricanaw River. Numerous shorelines around Hudson and St. James Bays are distinctive in winter because of snow cover. According to NASA scientists, shorelines were created when the overlying glaciers retreated and the land underneath rebounded causing the Hudson and St. James Bay waters to retreat northward. These ridges are 100 to 200 meters in width and heights can reach up to 7 meters. The land along St. James Bay consists mainly of tidal flats and salt marshes.

Hannah's Prior Knowledge about Chemicals: A Case Study of One Fourth-Grade Child

ERIC Educational Resources Information Center

Bretz, Stacey Lowery; Emenike, Mary Elizabeth

2012-01-01

Chemical principles are taught in elementary education across much of the United States because the "National Science Education Standards" include concepts about the nature of matter, states of matter, and changes in matter among other science concepts within the first to fifth grade levels. "Chemicals" is a word related to the nature of matter…

Genetic testing: new challenges in the healthcare of women. Interview by Hannah Branch.

PubMed

Hofmann, Wera; Branch, Hannah

2013-11-01

Dr Wera Hofmann is an expert in biochemistry and has over 12 years of human genetic diagnostics experience. Until 2006, she supervised a diagnostic unit for BRCA gene testing at the Interdisciplinary Center for Hereditary Breast Cancer (Max Delbrück Center, Berlin, Germany). She has also been the Managing Director of the Professional Association of German Human Geneticists, BVDH, which is a trade association. In 2008, Hofmann became a Medical Director at LifeCodexx (Konstanz, Germany), where she has worked on the development of a noninvasive prenatal diagnostic test that detects chromosomal aneuploidies in fetuses.

Die Deutsche Statistische Gesellschaft in der Weimarer Republik und während der Nazidiktatur

NASA Astrophysics Data System (ADS)

Wilke, Jürgen

Nach anfänglichen Schwierigkeiten durch den 1. Weltkrieg erlangte die Deutsche Statistische Gesellschaft (DStatG) unter dem renommierten Statistiker und Vorsitzenden der DStatG, Friedrich Zahn, durch eine Vielzahl von Aktivitäten hohes Ansehen. Es gab Bestrebungen, Statistiker aus allen Arbeitsfeldern der Statistik in die DStatG zu integrieren, wobei die "Mathematische Statistik" nur zögerlich akzeptiert wurde (Konjunkturforschung, Zeitreihenanalyse). Nach der Machtübernahme 1933 durch Adolf Hitler geriet die DStatG in das Fahrwasser nationalsozialistischer Ideologie und Politik (Führerprinzip, Gleichschaltung des Vereinswesens). Damit war eine personelle Umstrukturierung in der DStatG verbunden. Politisch Missliebige und rassisch Verfolgte mussten die DStatG verlassen (Bernstein, Freudenberg, Gumbel u.a.). Unter den Statistikern gab es alle Abstufungen im Verhalten zum Regime von Ablehnung und zwangsweiser Anpassung über bereitwilliges Mitläufertum bis zu bewusster Täterschaft. Besonders die Bevölkerungsstatistik wurde durch die NS- Rassenpolitik auf lange Sicht diskreditiert. Im Rahmen von Wirtschaftsplanung und Aufrüstung wurden neue zukunftsträchtige statistische Modelle (Grünig, Bramstedt, Leisse) entwickelt.

Interview: An architectural journey: from trees, dendrons/dendrimers to nanomedicine. Interview by Hannah Stanwix.

PubMed

Tomalia, Donald A

2012-07-01

Donald Tomalia received his Bachelor of Arts degree in Chemistry from the University of Michigan (MI, USA). He received his PhD in physical-organic Chemistry from Michigan State University (MI, USA) in 1968 while working at The Dow Chemical Company (MI, USA). In 1990 he moved to Michigan Molecular Institute (MI, USA) as Professor and Director of Nanoscale Chemistry and Architecture. He has subsequently founded three dendrimer based-nanotechnology companies, Dendritech, Inc. (MI, USA), Dendritic Nanotechnologies, Inc. (MI, USA) and NanoSynthons LLC (MI, USA). Donald Tomalia is currently Director of the National Dendrimer & Nanotechnology Center (MI, USA), CEO/founder of NanoSynthons LLC (MI, USA), distinguished visiting Professor, Columbia University (NY, USA) and affiliate Professor, Department of Physics, Virginia Commonwealth University (VA, USA). He is best known for his discovery of dendrimers and has received several awards for his accomplishments and contributions to science, including the 2012 Wallace H Carothers Award. He has authored over 250 publications, as well as over 128 patents.

Simulation of Quiet-Sun Hard X-rays Related to Solar Wind Superhalo Electrons

NASA Astrophysics Data System (ADS)

Wang, W.; Wang, L.; Krucker, S.; Hannah, I. G.

2016-12-01

Abstract. In this paper, we propose that the accelerated electrons in the quiet-Sun could collide with the solar atmosphere to emit Hard X-rays (HXRs) via non-thermal bremsstrahlung, while some of these electrons would move upwards and escape into the interplanetary medium, to form a superhalo electron population measured in the solar wind. After considering the electron energy loss due to Coulomb collisions and the ambipolar electrostatic potential, we find that the sources of superhalo could only occur high in the corona (at a heliocentric altitude ≥ 1.9 Rs), to remain a power-law shape of electron spectrum as observed by STEREO at 1 AU near solar minimum (Wang et al, 2012).The modeled quiet-Sun HXRs related to the superhalo electrons fit well to a power-law spectrum, f(ɛ) ∝ ɛ-γ, with an index γ ≈ 2.0-2.3 (3.3-3.7) at 10-100 keV, for the warm/cold thick-target (thin-target) emissions produced by the downward-traveling (upward-traveling) accelerated electrons. These simulated quiet-Sun spectra are significantly harder than the observed spectra of most solar HXR flares. Assuming that the quiet-Sun sources cover 5% of the solar surface, the modeled thin-target HXRs are more than six orders of magnitude weaker than the RHESSI upper limits of quiet-Sun HXRs (Hannah et al., 2010). Using the thick-target model for the downward-traveling electrons, the RHESSI upper limits restrict the number of downward-traveling electrons to maximal ≈ 3 times the number of escaping electrons. This ratio is fundamentally different from what is observed during solar flares associated with escaping electrons where the fraction of downward-traveling electrons dominates by a factor of 100 to 1000 over the escaping population. References: 1. Hannah et al., APJ, 724, 487(2010) 2. Wang et al., APJ Letters,753,L23(2012) 3. Yang et al., RAA,Vol.15,No.3,348-362(2015) 4. Brown J.C., Solar Physics,Vol.18,Issue 3,489,502­­­(1971)

Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins.

PubMed

Yamazaki, Yasuo; Hyodo, Fumiko; Morita, Takashi

2003-04-01

Cysteine-rich secretory proteins (CRISPs) are found in epididymis and granules of mammals, and they are thought to function in sperm maturation and in the immune system. Recently, we isolated and obtained clones for novel snake venom proteins that are classified as CRISP family proteins. To elucidate the distribution of snake venom CRISP family proteins, we evaluated a wide range of venoms for immuno-cross-reactivity. Then we isolated, characterized, and cloned genes for three novel CRISP family proteins (piscivorin, ophanin, and catrin) from the venom of eastern cottonmouth (Agkistrodon piscivorus piscivorus), king cobra (Ophiophagus hannah), and western diamondback rattlesnake (Crotalus atrox). Our results show the wide distribution of snake venom CRISP family proteins among Viperidae and Elapidae from different continents, indicating that CRISP family proteins compose a new group of snake venom proteins.

Recent and future advances in anticancer drug delivery: an interview with Khaled Greish.

PubMed

Greish, Khaled

2018-05-01

Khaled Greish speaks to Hannah Makin, Commissioning Editor: Khaled Greish is Associate Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published >70 peer reviewed papers, and ten book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him "Early Career Awards for Distinction in Research" in 2014. His research focuses on nanomedicine, tumor vascular biology and anticancer drug discovery/development.

17. Copy of a post card showing the Lavelle School ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Copy of a post card showing the Lavelle School and its first graduating class, c. 1890. The people are identified as: (1st row L to R) Charles Walker, Raymond Hornberger, Kenneth Keller, Dan Walker, Gilbert Lenker, and John Wetzel (from Locustdale); (2nd row L to R) Tim Snyder, Art Hornberger, John Wetzel (from Lavelle), ? Keller, Bright Enterline, Emerson Keller, Art Krah, and Leroy Henninger; (3rd row L to R) Hannah Wetzel, Vernie Hepler, Nona Snyder, Alice Dillman, Edith (Krah) Wolfgang, and Florence (Leach) Paul; (4th row L to R) Elva Paul, Vernie Wolfgang, Marie Enterline Walker, and Annie Hunter; (5th row L to R) Edna Walker, Martha Hornberger (Teacher), and Emma Dillman. (Copy of photo reproduced with permission from the Ashland Public ... - Lavelle School, Township Road 905, Main Street, Village of Lavelle, Lavelle, Schuylkill County, PA

Venomous snakebite in Thailand. I: Medically important snakes.

PubMed

Chanhome, L; Cox, M J; Wilde, H; Jintakoon, P; Chaiyabutr, N; Sitprija, V

1998-05-01

Thailand has an abundance of venomous snakes. Among the neurotoxic family Elapidae, there are three species of the genus Naja (cobras), three of the genus Bungarus (kraits), and the king cobra of the genus Ophiophagus. Other Elapidae snakes in Thailand include sea snakes and Asian coral snakes of the genus Calliophis. They have potent venoms but rarely bite humans. Tissue and hemotoxic snakes are represented by family Viperidae, subfamilies Viperinae and Crotalinae. They remain an occupational hazard for farmers and rubber tappers, causing serious morbidity but only rare deaths, since competent treatment is now widely available throughout Thailand. Purified equine antivenin is manufactured locally for the monocled and Siamese spitting cobras (Naja kaouthia and N. siamensis), king cobra (Ophiophagus hannah), banded krait (Bungarus fasciatus), most green pit vipers (Trimeresurus sp.), Malayan pit viper (Calloselasma rhodostoma), and the Siamese Russell's viper (Daboia russelli siamensis).

[Sequencing and analysis of the complete mitochondrial genome of the King Cobra, Ophiophagus hannah (Serpents: Elapidae)].

PubMed

Chen, Nian; Lai, Xiao-Ping

2010-07-01

We obtained the complete mitochondrial genome of King Cobra(GenBank accession number: EU_921899) by Ex Taq-PCR, TA-cloning and primer-walking methods. This genome is very similar to other vertebrate, which is 17 267 bp in length and encodes 38 genes (including 13 protein-coding, 2 ribosomal RNA and 23 transfer RNA genes) and two long non-coding regions. The duplication of tRNA-Ile gene forms a new mitochondrial gene rearrangement model. Eight tRNA genes and one protein genes were transcribed from L strand, and the other genes were transcribed genes from H strand. Genes on the H strand show a fairly similar content of Adenosine and Thymine respectively, whereas those on the L strand have higher proportion of A than T. Combined rDNA sequence data (12S+16S rRNA) were used to reconstruct the phylogeny of 21 snake species for which complete mitochondrial genome sequences were available in the public databases. This large data set and an appropriate range of outgroup taxa demonstrated that Elapidae is more closely related to colubridae than viperidae, which supports the traditional viewpoints.

Personalized Medicine Across Disciplines and without Borders. Vural Özdemir speaks to Hannah Wilson, Commissioning Editor.

PubMed

Özdemir, Vural

Vural Özdemir began his career as a medical doctor in Turkey in 1990, as a scientist at the Faculty of Medicine, University of Toronto (ON, Canada), where he obtained his MSc and PhD in clinical pharmacology (1998), and subsequently completed a 4-year postdoctoral fellowship in personalized medicine with the late Werner Kalow, a founding pioneer in the field of pharmacogenetics. Özdemir contributed to the conception and development of the repeated drug administration (RDA) method as a novel way of measuring pharmacological heritability, pharmacogenetics of psychiatric drugs and studying the clinical role of CYP2D6 genetic variations for endogenous neurotransmitter metabolism in the human brain. Recognizing that scientific knowledge is a product of both technology and social systems that often remain unaccounted for (e.g., human values, distribution of power and human agency, immigration, racial disparities, socioeconomic class and equity), Özdemir discovered the literature in the field of science and technology studies, a rich scholarly enquiry that asks fundamental questions and challenges assumptions regarding the backstage of technoscience, situates technology within its political context and makes hitherto unseen connections that frame science in ways that enable robust, responsible and sustainable innovation. From 2008 to 2012, Özdemir was awarded a mid-career "science and society" fellowship in order to retool as independent faculty and senior scientist in science and technology studies (STS), conducting research on research and examining his own trade - pharmacogenetics science - as an insider on the outside. Recently, Özdemir was awarded senior career support from the Scientific and Tehnological Research Council of Turkey, is an Associate Professor of both Communications and Human Genetics at the Faculty of Communications and serves as an advisor to the Rector for International Technology and Innovation Policy, Gaziantep University in Turkey. He is also a Visiting Professor (Global Health & Technology Foresight) at Amrita University in Kerala, India, and cofounder of the Data-Enabled Life Sciences Alliance (DELSA Global), an open innovation and knowledge translation platform in Seattle (WA, USA). Özdemir was named as coinventor of 12 World Intellectual Property Organization (WIPO) indexed patents in personalized medicine and has authored more than 130 peer reviewed articles and chapters on the translation of omics technologies into public health action, global technology governance, diagnostics innovation strategy, history of bioethics and the ethics-of-bioethics. 'Science Peace Corps' and 'Microgrants for Big Data' are two new knowledge translation and science communication concepts developed by Özdemir for the global governance of biotechnology. He is Editor-in-Chief of OMICS: A Journal of Integrative Biology , published by Mary Ann Liebert, Inc. (NY, USA).

Nurses across borders: foregrounding international migration in nursing history.

PubMed

Choy, Catherine Ceniza

2010-01-01

Although the international migration of nurses has played a formative role in increasing the racial and ethnic diversity of the health care labor force, nursing historians have paid very little attention to the theme of international migration and the experiences of foreign-trained nurses, A focus on international migration complements two new approaches in nursing history: the agenda to internationalize its frameworks, and the call to move away from "great women, great events" and toward the experiences of "ordinary" nurses. This article undertakes a close reading of the life and work of Filipino American nurse Ines Cayaban to reconceptualize nursing biography in an international framework that is attentive to issues of migration, race, gender, and colonialism. It was a Hannah keynote lecture delivered by the author on June 5, 2008, as part of the CAHN/ACHN (Canadian Association for the History of Nursing/Association Canadienne pour l'Histoire du Nursing) International Nursing History Conference.

Leading the way in biomedical engineering: an interview with Robert Langer. Interview by Hannah Stanwix, Commissioning Editor.

PubMed

Langer, Robert

2012-10-01

Professor Robert Langer obtained his Bachelor's Degree in Chemical Engineering from Cornell University (NY, USA) in 1970. He received his Sc.D. from the Massachusetts Institute of Technology (MA, USA) in 1974. He is currently the David H Koch Institute Professor at the Massachusetts Institute of Technology. Professor Langer is a member of the Institute of Medicine of the National Academy of Sciences, the National Academy of Engineering and the National Academy of Sciences. At the age of 43 he was the youngest person in history to be elected to all three United States National Academies. Throughout his career, Professor Langer has received over 200 awards including, notably, the Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers), the 2008 Millennium Prize, the 2006 United States National Medal of Science and the 2012 Priestley Medal. In 1996 he was awarded the Gairdner Foundation International Award (the only engineer ever to have been awarded this accolade). Professor Langer has also been the recipient of the Lemelson-MIT prize, which he was awarded with for being "one of history's most prolific inventors in medicine." Professor Langer was selected by Time Magazine in 2001 as one of the 100 most important people in the USA. He has received honorary degrees from several universities worldwide, including Harvard University (MA, USA), the Mt. Sinai School of Medicine (NY, USA), Yale University (CT, USA), the ETH Zurich (Zurich, Switzerland), the Technion-Israel Institute of Technology (Haifa, Israel), the Hebrew University of Jerusalem (Israel), the Université Catholique de Louvain (Louvain-La-Neuve, Belgium), Rensselaer Polytechnic Institute (NY, USA), Willamette University (OR, USA), the University of Liverpool (Liverpool, UK), Bates College (ME, USA), the University of Nottingham (Nottingham, UK), Albany Medical College (NY, USA), Pennsylvania State University (PA, USA), Northwestern University (IL, USA) and Uppsala University (Uppsala, Sweden), and was awarded with the University of California San Francisco Medal in 2009. Professor Langer has founded over 20 biotechnology companies and authored more than 1175 articles. He has over 800 issued or pending patents. Professor Langer is the most cited engineer in history.

Isolation and cloning of a metalloproteinase from king cobra snake venom.

PubMed

Guo, Xiao-Xi; Zeng, Lin; Lee, Wen-Hui; Zhang, Yun; Jin, Yang

2007-06-01

A 50 kDa fibrinogenolytic protease, ohagin, from the venom of Ophiophagus hannah was isolated by a combination of gel filtration, ion-exchange and heparin affinity chromatography. Ohagin specifically degraded the alpha-chain of human fibrinogen and the proteolytic activity was completely abolished by EDTA, but not by PMSF, suggesting it is a metalloproteinase. It dose-dependently inhibited platelet aggregation induced by ADP, TMVA and stejnulxin. The full sequence of ohagin was deduced by cDNA cloning and confirmed by protein sequencing and peptide mass fingerprinting. The full-length cDNA sequence of ohagin encodes an open reading frame of 611 amino acids that includes signal peptide, proprotein and mature protein comprising metalloproteinase, disintegrin-like and cysteine-rich domains, suggesting it belongs to P-III class metalloproteinase. In addition, P-III class metalloproteinases from the venom glands of Naja atra, Bungarus multicinctus and Bungarus fasciatus were also cloned in this study. Sequence analysis and phylogenetic analysis indicated that metalloproteinases from elapid snake venoms form a new subgroup of P-III SVMPs.

Ophidascaris wangi sp. n. and O. najae (Gedoelst, 1916) (Ascaridida: Ascaridoidea) from snakes in China.

PubMed

Li, Liang; Guo, Yan-Ning; Li, Jian; Zhang, Lu-Ping

2014-12-01

Ophidascaris wangi sp. n. collected from the king rat snake Elaphe carinata (Günther) (Serpentes: Colubridae) in China is described using both light and scanning electron microscopy. The new species differs from its congeners in the presence of narrow lateral alae originating a short distance posterior to the base of the ventrolateral lips, its relatively long oesophagus (3.57-4.54 mm long, representing 6.6-7.6% of body length), its short spicules (1.89-2.14 mm long, representing 3.9-4.3% of body length), the number and arrangement of caudal papillae (49-57 pairs in total, arranged as follows: 43-51 pairs precloacal, 2 pairs joined paracloacal and 4 pairs postcloacal), the presence of a particular papilliform medioventral, postcloacal ornamentation and the morphology of the eggs and tip of the female tail. In addition, Ophidascaris najae (Gedoelst, 1916), collected from the king cobra Ophiophagus hannah Cantor (Serpentes: Elapidae) in China, is also redescribed. The morphology of the cervical papillae, labial denticles and phasmids of the female is described for the first time.

Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom.

PubMed

He, Ying-Ying; Liu, Shu-Bai; Lee, Wen-Hui; Qian, Jin-Qiao; Zhang, Yun

2008-10-01

Snake venom Kunitz/BPTI members are good tools for understanding of structure-functional relationship between serine proteases and their inhibitors. A novel dual Kunitz/BPTI serine proteinase inhibitor named OH-TCI (trypsin- and chymotrypsin-dual inhibitor from Ophiophagus hannah) was isolated from king cobra venom by three chromatographic steps of gel filtration, trypsin affinity and reverse phase HPLC. OH-TCI is composed of 58 amino acid residues with a molecular mass of 6339Da. Successful expression of OH-TCI was performed as the maltose-binding fusion protein in E. coli DH5alpha. Much different from Oh11-1, the purified native and recombinant OH-TCI both had strong inhibitory activities against trypsin and chymotrypsin although the sequence identity (74.1%) between them is very high. The inhibitor constants (K(i)) of recombinant OH-TCI were 3.91 x 10(-7) and 8.46 x10(-8)M for trypsin and chymotrypsin, respectively. To our knowledge, it was the first report of Kunitz/BPTI serine proteinase inhibitor from snake venom that had equivalent trypsin and chymotrypsin inhibitory activities.

Patrick Couvreur: inspiring pharmaceutical innovation.

PubMed

Stanwix, Hannah

2014-05-01

Patrick Couvreur speaks to Hannah Stanwix, Managing Comissioning Editor: Professor Patrick Couvreur received his pharmacy degree from the Université Catholique de Louvain (Louvain-la-Neuve, Belgium) in 1972. He holds a PhD in pharmaceutical technology from the same university and completed a postdoctoral fellowship at the Eidgenössische Technische Hochschule (Zürich, Switzerland). Since 1984, Professor Couvreur has been Full Professor of Pharmacy at the Paris-Sud University (Paris, France) and was holder of the Chair of Innovation Technologique at the prestigious Collège de France (Paris, France). He has published more than 450 peer-reviewed articles and has an H-index of 73, with over 19,000 citations. Professor Coureur has been recognized by numerous national and international awards, including the 2004 Pharmaceutical Sciences World Congress Award, the prestigious Host Madsen Medal, the Prix Galien, the European Pharmaceutical Scientist Award 2011 from the European Federation of Pharmaceutical Sciences, the Médaille de l'Innovation from the Centre National de la Recherche Scientifique, and recently the European Inventor Award 2013 from the European Patent Office.

ZOONET: perspectives on the evolution of animal form. Meeting report.

PubMed

Fischer, Antje H L; Arboleda, Enrique; Egger, Bernhard; Hilbrant, Maarten; McGregor, Alistair P; Cole, Alison G; Daley, Allison C

2009-11-15

What drives evolution? This was one of the main questions raised at the final ZOONET meeting in Budapest, Hungary, in November 2008. The meeting marked the conclusion of ZOONET, an EU-funded Marie-Curie Research Training Network comprising nine research groups from all over Europe (Max Telford, University College London; Michael Akam, University of Cambridge; Detlev Arendt, EMBL Heidelberg; Maria Ina Arnone, Stazione Zoologica Anton Dohrn Napoli; Michalis Averof, IMBB Heraklion; Graham Budd, Uppsala University; Richard Copley, University of Oxford; Wim Damen, University of Cologne; Ernst Wimmer, University of Göttingen). ZOONET meetings and practical courses held during the past four years provided researchers from diverse backgrounds--bioinformatics, phylogenetics, embryology, palaeontology, and developmental and molecular biology--the opportunity to discuss their work under a common umbrella of evolutionary developmental biology (Evo Devo). The Budapest meeting emphasized in-depth discussions of the key concepts defining Evo Devo, and bringing together ZOONET researchers with external speakers who were invited to present their views on the evolution of animal form. The discussion sessions addressed four main topics: the driving forces of evolution, segmentation, fossils and phylogeny, and the future of Evo Devo.

Aging as a social form: the phenomenology of the passage.

PubMed

Blum, Alan

2014-03-01

If philosophers have discussed life as preparation for death, this seems to make aging coterminous with dying and a melancholy passage that we are condemned to survive. It is important to examine the discourse on aging and end of life and the ways various models either limit possibilities for human agency or suggest means of being innovative in relation to such parameters. I challenge developmental views of aging not by arguing for eternal life, but by using Plato's conception of form in conjunction with Simmel's work and Arendt's meditation on intergenerational solidarity, to evoke a picture of the subject as having capacities that offer avenues for improvisational action. This paper proposes a method for analyzing any social form as a problem-solving situation where the real "problem" is the fundamental ambiguity that inheres in the mix between the finite characteristics of the action and its infinite perplexity. I work through the most conventional chronological view of aging to show how it dramatizes a fundamental ethical collision in life that intensifies anxiety under many conditions, always raising the question of what is to be done with respect to contingency, revealing such "work" as a paradigm of the human condition.

How singleton breech babies at term are born in France: a survey of data from the AUDIPOG network.

PubMed

Lansac, J; Crenn-Hebert, C; Rivière, O; Vendittelli, F

2015-05-01

Based on data from the AUDIPOG sentinel network between 1994 and 2010, we can say that the rate of singleton breech presentation at term is 3% and remains unchanged despite an external cephalic version rate of 35%. The total cesarean section rate is currently 75%. This rate increased by nearly 20% after the Hannah publication in 2000, regardless of the type of breech and type of maternity unit. The rate of planned cesarean sections increased in particular, going from 40% to 60%, and even reaching 67% for footling breech presentations. The rate is higher in type I maternity units than in type II or III. This cesarean section rate has been stable since 2005 and has even decreased for the Frank breech. The average rate of external cephalic version remains stable at around 23%. The episiotomy rate is 28%. The rate of babies transferred to neonatology units is higher for breech babies at term than for babies presenting cephalically (3.9% compared to 2.9%), but the newborns most often transferred are those born by cesarean section (4.1% compared to 3.4%). Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Development of a polymerase chain reaction to distinguish monocellate cobra (Naja khouthia) bites from other common Thai snake species, using both venom extracts and bite-site swabs.

PubMed

Suntrarachun, S; Pakmanee, N; Tirawatnapong, T; Chanhome, L; Sitprija, V

2001-07-01

A PCR technique was used in this study to identify and distinguish monocellate cobra snake bites using snake venoms and swab specimens from snake bite-sites in mice from bites by other common Thai snakes. The sequences of nucleotide primers were selected for the cobrotoxin-encoding gene from the Chinese cobra (Naja atra) since the sequences of monocellate cobra (Naja kaouthia) venom are still unknown. However, the 113-bp fragment of cDNA of the cobrotoxin-encoding gene was detected in the monocellate cobra venom using RT-PCR. This gene was not found in the venoms of Ophiophagus hannah (king cobra), Bungarus fasciatus (banded krait), Daboia russelii siamensis (Siamese Russell's Viper, and Calloselasma rhodostoma (Malayan pit viper). Moreover, direct PCR could detect a 665-bp fragment of the cobrotoxin-encoding gene in the monocellate cobra venom but not the other snake venoms. Likewise, this gene was only observed in swab specimens from cobra snake bite-sites in mice. This is the first report demonstrating the ability of PCR to detect the cobrotoxin-encoding gene from snake venoms and swab specimens. Further studies are required for identification of this and other snakes from the bite-sites on human skin.

Molecular barcoding of venomous snakes and species-specific multiplex PCR assay to identify snake groups for which antivenom is available in Thailand.

PubMed

Supikamolseni, A; Ngaoburanawit, N; Sumontha, M; Chanhome, L; Suntrarachun, S; Peyachoknagul, S; Srikulnath, K

2015-10-30

DNA barcodes of mitochondrial COI and Cytb genes were constructed from 54 specimens of 16 species for species identification. Intra- and interspecific sequence divergence of the COI gene (10 times) was greater than that of the Cytb gene (4 times), which suggests that the former gene may be a better marker than the latter for species delimitation in snakes. The COI barcode cut-off scores differed by more than 3% between most species, and the minimum interspecific divergence was greater than the maximum intraspecific divergence. Clustering analysis indicated that most species fell into monophyletic clades. These results suggest that these species could be reliably differentiated using COI DNA barcodes. Moreover, a novel species-specific multiplex PCR assay was developed to distinguish between Naja spp, Ophiophagus hannah, Trimeresurus spp, Hydrophiinae, Daboia siamensis, Bungarus fasciatus, and Calloselasma rhodostoma. Antivenom for these species is produced and kept by the Thai Red Cross for clinical use. Our novel PCR assay could easily be applied to venom and saliva samples and could be used effectively for the rapid and accurate identification of species during forensic work, conservation study, and medical research.

20 Years is not long enough.

PubMed

Korol, Lucía

2005-08-01

The author presents some Latin American sociopolitical vicissitudes exemplified by Argentina, where she lives and where she trained and practices as a psychoanalyst. The exposition is based on the impact that her experience with two patients, Ana and Juana, had on her, and is presented in the form of clinical vignettes. The author reflects clinically and technically on the transference and countertransference and on the ways in which self-analysis enabled her to distinguish between the countertransference related to the patient and that related to the psychoanalyst. Finally, the author discusses the traumatic effects of 'the human condition', 'social violence' and 'Evil', referring specifically to the 'repetitive trauma' individuals experience under the globalization of terror and to the use of mechanisms of disavowal that result in serious splitting. The author confronts the reader with totalitarian terror as something that attacks and destroys the main constitutive characteristic of human beings, namely, their ability to think, remarking that H. Arendt is the one who speaks about 'radical evil' as 'the banality of Evil'. The author addresses the question of whether by tempering aggression and organizing levels of symbolization 'words' might prevent the emergence of 'pure jouissance' and be more powerful and significant than violence, overriding it.

Annotations to D.B. Herrmann's contribution ``On Albert Einstein's political views'' (German Title: Anmerkungen zu D.B. Herrmanns Beitrag ``Über Albert Einsteins politische Ansichten'')

NASA Astrophysics Data System (ADS)

Grundmann, Siegfried

Referring to the Straus-Herrmann correspondence, we deal only with one aspect of the ``political Einstein'': his attitude towards Marx, Engels, Lenin and Stalin (who were in the past sometimes called the ``classics of Marxism-Leninism''). Einstein revered Marx, but condemned Stalin as a criminal. He also resisted attempts to be misused by representatives of ``dialectic materialism''.

[Genesis and political background of "Sonderaktion Krakau" 6 XI 1939].

PubMed

August, J

1998-01-01

The decision to imprison Cracow's University professors on November 6, 1939 was made in connection with the establishment of the so-called General Government, as a second stage of German security police action in nazi-occupied Poland to ensure German rule also over Central and Southern Poland. By this way Sonderaktion Krakau (Special Action Cracow)--as continuation of politische Flurbereinigung (political cleaning up) started in German occupied Western Poland in September 1939--was a part of a second wave of persecution directed against the Polish societies' social classes indicated by Nazi leaders and chiefs of German security police as Poland's leadership, a wave of persecution now, since the end of October 1939, enlarged on Central and Southern Poland. The imprisonment of the Cracow Professors subsequently marked the perspective, that Poland's scientific and academic institutions as a whole would be destroyed, so that in future no Polish scientists, intellectuals and university people even would have the possibility to do scientific work and to have subsistence from doing this kind of work. As a consequence, Poland's intellectuals and university-trained people as a social class in future would disappear indefinitely, and the people of Poland, deprived of intellectual leadership, would be transformed into a mass of dependend lower-class working people, so that the Nazi leaders mournfull future-scenario for their rule in German occupied Central and Eastern Europe would become reality. By this way the imprisonment of the Cracow Professors on November 6, 1939 was the first step to realize Nazi future plans concerning Central and Eastern Europe.

Towards the inversion of GRACE gravity fields for present-day ice-mass changes and glacial-isostatic adjustment in North America and Greenland

NASA Astrophysics Data System (ADS)

Sasgen, Ingo; Klemann, Volker; Martinec, Zdeněk

2012-09-01

We perform an inversion of gravity fields from the Gravity Recovery and Climate Experiment (GRACE) (August 2002 to August 2009) of four processing centres for glacial-isostatic adjustment (GIA) over North America and present-day ice-mass change in Alaska and Greenland. We apply a statistical filtering approach to reduce noise in the GRACE data by confining our investigations to GRACE coefficients containing a statistically significant linear trend. Selecting the subset of reliable coefficients in all GRACE time series (GFZ RL04, ITG 2010, JPL RL04 and CSR RL04) results in a non-isotropic smoothing of the GRACE gravity fields, which is effective in reducing the north-south oriented striping associated with correlated errors in GRACE coefficients. In a next step, forward models of GIA induced by the glacial history NAWI (Zweck and Huybrechts, 2005), as well as present-day ice mass changes in Greenland from ICESat (Sørensen et al., 2011) and Alaska from airborne laser altimetry (Arendt et al., 2002) are simultaneously adjusted in scale to minimize the misfit to the filtered GRACE trends. From the adjusted models, we derive the recent sea-level contributions for Greenland and Alaska (August 2002 to August 2009), and, interpret the residual misfit over the GIA-dominated region around the Hudson Bay, Canada, in terms of mantle viscosities beneath North America.

Evil is more than banal: situationism and the concept of evil.

PubMed

Berkowitz, L

1999-01-01

Social psychology as a discipline has given relatively little attention to the problem of evil in society, and those discussions in this field that do exist typically regard evil actions as only varieties of aggression without any characteristics that distinguish them from other forms of intentional mistreatment of others. Because of the field's situationistic perspective emphasizing the individual's susceptibility to the power of the immediate situation, social psychoiogists generally view the fairly high levels of obedience to authority displayed in Milgram's (1963, 1974) classic experiment as the paradigmatic example of evil behavior. For them, much evil is, in Arendt's (1963) well-known phrase, only "banal," and Milgram's findings are often viewed as illustrating the "central dynamic" involved in the slaughter of millions of Jews and other "undesirables" in the Holocaust. This article holds that Milgram's (1974) obedience research does not represent significant features of the Holocaust, especially the sadism that occurred not infrequently, and disregards the vital difference between those who initiated the murderous policy and the others who followed their orders. Building on Darley's (1992) earlier conjectures about the features that ordinary people might consider in judging whether any given action is evil, I suggest that many persons have a prototypic conception of evil and speculate about the dimensions that could be involved in this prototype.

X-Ray Dust Scattering At Small Angles: The Complete Halo Around GX13+1

NASA Technical Reports Server (NTRS)

Smith, Randall K.

2007-01-01

The exquisite angular resolution available with Chandra should allow precision measurements of faint diffuse emission surrounding bright sources, such as the X-ray scattering halos created by interstellar dust. However, the ACIS CCDs suffer from pileup when observing bright sources, and this creates difficulties when trying to extract the scattered halo near the source. The initial study of the X-ray halo around GX13+1 using only the ACIS-I detector done by Smith, Edgar & Shafer (2002) suffered from a lack of sensitivity within 50" of the source, limiting what conclusions could be drawn. To address this problem, observations of GX13+1 were obtained with the Chandra HRC-I and simultaneously with the RXTE PCA. Combined with the existing ACIS-I data, this allowed measurements of the X-ray halo between 2-1000". After considering a range of dust models, each assumed to be smoothly distributed with or without a dense cloud along the line of sight, the results show that there is no evidence in this data for a dense cloud near the source, as suggested by Xiang et al. (2005). In addition, although no model leads to formally acceptable results, the Weingartner & Draine (2001) and all but one of the composite grain models from Zubko, Dwek & Arendt (2004) give particularly poor fits.

From the West Wing to Pink Floyd to Einstein Advertising: Astronomy in Popular Culture

NASA Astrophysics Data System (ADS)

Fraknoi, Andrew

2007-12-01

In what popular movie does Darryl Hannah play an astronomer? What Japanese car company is named after a well-known star cluster? Can you name at least two murder mysteries that take place at an observatory? What national astronomy education project was mentioned on The West Wing television show (which had several "stealth astronomy” episodes)? What piece of classical music begins with a Big Bang and has the players expanding on stage and into the concert hall? Can you recite the most famous neutrino poem and name the poet? What science fiction story, written by an astronomer under a pseudonym, features an H-R diagram? What rock group had its members’ names included in a reference in the Astrophysical Journal, unbeknownst to the editor? How many astronomy related operas can you name? How many astronomers does it take to screw in a light bulb? Join in on an exploration of astronomy in popular culture, from stamp collecting to advertising, from science fiction (with accurate astronomy) to rock music, from Broadway musicals to modern poetry. Learn which astronomy colleagues have been writing fiction and poetry while you were busy publishing in the research literature. Bring your favorite example of astronomy in popular culture and we'll take the time at the end to share ideas and have some fun. A resource guide for exploring astronomy and popular culture will be available.

Isolation of Campylobacter spp. from Three Species of Antarctic Penguins in Different Geographic Locations.

PubMed

García-Peña, F J; Llorente, M T; Serrano, T; Ruano, M J; Belliure, J; Benzal, J; Herrera-León, S; Vidal, V; D'Amico, V; Pérez-Boto, D; Barbosa, A

2017-03-01

The presence of Campylobacter species was studied in three Antarctic penguin species, Adélie (Pygoscelis adeliae), chinstrap (Pygoscelis antarctica) and gentoo (Pygoscelis papua). A total of 390 penguins were captured in 12 different rookeries along the Antarctic Peninsula with differences in the amount of human visitation: six colonies were highly visited [Stranger Point, King George Island (P. papua and P. adeliae); Hannah Point, Livingston Island (P. papua and P. antarctica); Deception Island (P. antarctica); and Paradise Bay, Antarctic Peninsula (P. papua)], and six colonies were rarely visited [Devil's Point, Byers Peninsula, Livingston Island (P. papua); Cierva Cove, Antarctic Peninsula (P. papua); Rongé Island (P. papua and P. antarctica); Yalour Island (P. adeliae); and Avian Island (P. adeliae)]. A total of 23 strains were isolated from penguins from nine different rookeries. Campylobacter lari subsp. lari was isolated from eight samples (seven from P. papua and one from P. adeliae); C. lari subsp. concheus from 13 (ten from P. adeliae and three from P. antarctica) and C. volucris from two samples (both from P. papua). We did not find any significant differences in the prevalence of Campylobacter spp. between the populations in highly and rarely visited areas. This is the first report of C. lari subsp. concheus and C. volucris isolation from penguins in the Antarctic region.

Event-related potentials reveal the relations between feature representations at different levels of abstraction.

PubMed

Hannah, Samuel D; Shedden, Judith M; Brooks, Lee R; Grundy, John G

2016-11-01

In this paper, we use behavioural methods and event-related potentials (ERPs) to explore the relations between informational and instantiated features, as well as the relation between feature abstraction and rule type. Participants are trained to categorize two species of fictitious animals and then identify perceptually novel exemplars. Critically, two groups are given a perfectly predictive counting rule that, according to Hannah and Brooks (2009. Featuring familiarity: How a familiar feature instantiation influences categorization. Canadian Journal of Experimental Psychology/Revue Canadienne de Psychologie Expérimentale, 63, 263-275. Retrieved from http://doi.org/10.1037/a0017919), should orient them to using abstract informational features when categorizing the novel transfer items. A third group is taught a feature list rule, which should orient them to using detailed instantiated features. One counting-rule group were taught their rule before any exposure to the actual stimuli, and the other immediately after training, having learned the instantiations first. The feature-list group were also taught their rule after training. The ERP results suggest that at test, the two counting-rule groups processed items differently, despite their identical rule. This not only supports the distinction that informational and instantiated features are qualitatively different feature representations, but also implies that rules can readily operate over concrete inputs, in contradiction to traditional approaches that assume that rules necessarily act on abstract inputs.

Structure-function relationships of curaremimetic neurotoxin loop 2 and of a structurally similar segment of rabies virus glycoprotein in their interaction with the nicotinic acetylcholine receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lentz, T.L.

1991-11-12

Peptides corresponding to portions of curaremimetic neurotoxin loop 2 and to a structurally similar segment of rabies virus glycoprotein were synthetically modified in order to gain information on structure-function relationships of neurotoxin loop 2 interactions with the acetylcholine receptor. Binding of synthetic peptides to the acetylcholine receptor of Torpedo electric organ membranes was assessed by measuring their ability to inhibit the binding of {sup 125}I-{alpha}-bungarotoxin to the receptor. The peptides showing the highest affinity for the receptor were a peptide corresponding to the sequence of loop 2 (residues 25-44) of Ophiophagus hannah (king cobra) toxin b and the structurally similarmore » segment of CVS rabies virus glycoprotein. These affinities were comparable to those of d-tubocurarine and suberyldicholine. These results demonstrate the importance of loop 2 in the neurotoxin interaction with the receptor. N- and C-terminal deletions of the loop 2 peptides and substitution of residues invariant or highly conserved among neurotoxins were performed in order to determine the role of individual residues in binding. Residues 25-40 are the most crucial in the interaction with the acetylcholine receptor. Since this region of the glycoprotein contains residues corresponding to all of the functionally invariant neurotoxin residues, it may interact with the acetylcholine receptor through a mechanism similar to that of the neurotoxins.« less

The Virtual Liver Network: systems understanding from bench to bedside.

PubMed

Henney, Adriano; Coaker, Hannah

2014-01-01

Adriano Henney speaks to Hannah Coaker, Commissioning Editor. After achieving a PhD in medicine and spending many years in academic research in the field of cardiovascular disease, Adriano Henney was recruited by Zeneca Pharmaceuticals from a British Heart Foundation Senior Fellowship, where he led the exploration of new therapeutic approaches in atherosclerosis, specifically focusing on his research interests in vascular biology. Following the merger with Astra to form AstraZeneca, Henney became responsible for exploring strategic improvements to the company's approaches to pharmaceutical target identification and the reduction of attrition in early development, directing projects across research sites and across functional project teams in the USA, Sweden and the UK. This resulted in the creation of a new multidisciplinary department that focused on pathway mapping, modeling and simulation and supporting projects across research and development, which evolved into the establishment of the practice of systems biology within the company. Here, projects prototyped the application of mechanistic disease-modeling approaches in order to support the discovery of innovative new medicines, such as Iressa®. Since leaving AstraZeneca, Henney has continued his interest in systems biology, synthetic biology and systems medicine through his company, Obsidian Biomedical Consulting Ltd. He now directs a major €50 million German national flagship program – the Virtual Liver Network – which is currently the largest systems biology program in Europe.

Erratum: ``Structure and Colors of Diffuse Emission in the Spitzer Galactic First Look Survey'' (ApJS, 154, 281 [2004])

NASA Astrophysics Data System (ADS)

Ingalls, James G.; Miville-Deschênes, M.-A.; Reach, William T.; Noriega-Crespo, A.; Carey, Sean J.; Boulanger, F.; Stolovy, S. R.; Padgett, Deborah L.; Burgdorf, M. J.; Fajardo-Acosta, S. B.; Glaccum, W. J.; Helou, G.; Hoard, D. W.; Karr, J.; O'Linger, J.; Rebull, L. M.; Rho, J.; Stauffer, J. R.; Wachter, S.

2006-05-01

We have discovered an error in the scaling of our IRAC 8 μm and MIPS 70 μm data, which affected the caption for Figure 1 and the vertical axis scales for Figure 2. The original units in the images displayed in Figure 1 were MJy sr-1 for 8 μm and μJy arcsec-2 for MIPS 24 and 70 μm. We incorrectly multiplied our IRAC data by 0.0425 (the conversion from μJy arcsec-2 to MJy sr-1), but neglected to multiply our MIPS 70 μm data by that factor. (MIPS 24 μm data were scaled correctly.) Thus, contrary to the caption of Figure 1, the gray levels for panels (a) and (b) actually range from 6.7 to 7.8 MJy sr-1, and the gray levels for panels (e) and (f) actually range from 0.85 to 20.8 MJy sr-1. The power spectra in Figure 2 should have been normalized such that the integral over the spectrum equals the mean square image surface brightness. In the original paper, however, the IRAC power spectrum was incorrectly multiplied by (0.0425)2, whereas the MIPS 70 μm spectrum should have been multiplied by this factor but was not. We correct this in a revised version of Figure 2 included here. We thank Rick Arendt for calling our attention to this error.

Interview: An interview with Chad Mirkin: nanomedicine expert

PubMed Central

Mirkin, Chad

2015-01-01

Chad Mirkin speaks to Hannah Stanwix, Assistant Commissioning Editor Professor Chad Mirkin received his Bachelor of Science Degree in Chemistry from Dickinson College (PA, USA) in 1986. He holds a PhD in Chemistry from Pennsylvania State University (PA, USA) and was a Postdoctoral Fellow at the Massachusetts Institute of Technology (MA, USA). He subsequently moved to Northwestern University (IL, USA) as a Professor of Chemistry in 1991. In 2004, Professor Mirkin became Director of the International Institute for Nanotechnology and holds that post currently. He is also the George B Rathmann Professor of Chemistry, Professor of Chemical and Biological Engineering, Professor of Biomedical Engineering, Professor of Materials Science and Engineering and Professor of Medicine at Northwestern University. Professor Mirkin is a member of the National Academy of Engineering, the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences. He is also currently a member of President Obama’s Council of Advisors for Science and Technology. Professor Mirkin is best known for his work on spherical nucleic acid nanoparticle conjugates and the invention of Dip-Pen Nanolithography. He has received over 70 awards and accolades for his accomplishments. Currently, based on total citations, Professor Mirkin is one of the most cited chemists and nanomedicine researchers in the world. He has authored over 500 publications, as well as over 440 patents and applications worldwide. PMID:22630148

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system.

PubMed

Vonk, Freek J; Casewell, Nicholas R; Henkel, Christiaan V; Heimberg, Alysha M; Jansen, Hans J; McCleary, Ryan J R; Kerkkamp, Harald M E; Vos, Rutger A; Guerreiro, Isabel; Calvete, Juan J; Wüster, Wolfgang; Woods, Anthony E; Logan, Jessica M; Harrison, Robert A; Castoe, Todd A; de Koning, A P Jason; Pollock, David D; Yandell, Mark; Calderon, Diego; Renjifo, Camila; Currier, Rachel B; Salgado, David; Pla, Davinia; Sanz, Libia; Hyder, Asad S; Ribeiro, José M C; Arntzen, Jan W; van den Thillart, Guido E E J M; Boetzer, Marten; Pirovano, Walter; Dirks, Ron P; Spaink, Herman P; Duboule, Denis; McGlinn, Edwina; Kini, R Manjunatha; Richardson, Michael K

2013-12-17

Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of a venomous snake, the king cobra (Ophiophagus hannah), and compared it, together with our unique transcriptome, microRNA, and proteome datasets from this species, with data from other vertebrates. In contrast to the platypus, the only other venomous vertebrate with a sequenced genome, we find that snake toxin genes evolve through several distinct co-option mechanisms and exhibit surprisingly variable levels of gene duplication and directional selection that correlate with their functional importance in prey capture. The enigmatic accessory venom gland shows a very different pattern of toxin gene expression from the main venom gland and seems to have recruited toxin-like lectin genes repeatedly for new nontoxic functions. In addition, tissue-specific microRNA analyses suggested the co-option of core genetic regulatory components of the venom secretory system from a pancreatic origin. Although the king cobra is limbless, we recovered coding sequences for all Hox genes involved in amniote limb development, with the exception of Hoxd12. Our results provide a unique view of the origin and evolution of snake venom and reveal multiple genome-level adaptive responses to natural selection in this complex biological weapon system. More generally, they provide insight into mechanisms of protein evolution under strong selection.

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics.

PubMed

Melani, Rafael D; Skinner, Owen S; Fornelli, Luca; Domont, Gilberto B; Compton, Philip D; Kelleher, Neil L

2016-07-01

Characterizing whole proteins by top-down proteomics avoids a step of inference encountered in the dominant bottom-up methodology when peptides are assembled computationally into proteins for identification. The direct interrogation of whole proteins and protein complexes from the venom of Ophiophagus hannah (king cobra) provides a sharply clarified view of toxin sequence variation, transit peptide cleavage sites and post-translational modifications (PTMs) likely critical for venom lethality. A tube-gel format for electrophoresis (called GELFrEE) and solution isoelectric focusing were used for protein fractionation prior to LC-MS/MS analysis resulting in 131 protein identifications (18 more than bottom-up) and a total of 184 proteoforms characterized from 14 protein toxin families. Operating both GELFrEE and mass spectrometry to preserve non-covalent interactions generated detailed information about two of the largest venom glycoprotein complexes: the homodimeric l-amino acid oxidase (∼130 kDa) and the multichain toxin cobra venom factor (∼147 kDa). The l-amino acid oxidase complex exhibited two clusters of multiproteoform complexes corresponding to the presence of 5 or 6 N-glycans moieties, each consistent with a distribution of N-acetyl hexosamines. Employing top-down proteomics in both native and denaturing modes provides unprecedented characterization of venom proteoforms and their complexes. A precise molecular inventory of venom proteins will propel the study of snake toxin variation and the targeted development of new antivenoms or other biotherapeutics. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Identification and characterization of novel reptile cathelicidins from elapid snakes.

PubMed

Zhao, Hui; Gan, Tong-Xiang; Liu, Xiao-Dong; Jin, Yang; Lee, Wen-Hui; Shen, Ji-Hong; Zhang, Yun

2008-10-01

Three cDNA sequences coding for elapid cathelicidins were cloned from constructed venom gland cDNA libraries of Naja atra, Bungarus fasciatus and Ophiophagus hannah. The open reading frames of the cloned elapid cathelicidins were all composed of 576bp and coded for 191 amino acid residue protein precursors. Each of the deduced elapid cathelicidin has a 22 amino acid residue signal peptide, a conserved cathelin domain of 135 amino acid residues and a mature antimicrobial peptide of 34 amino acid residues. Unlike the highly divergent cathelicidins in mammals, the nucleotide and deduced protein sequences of the three cloned elapid cathelicidins were remarkably conserved. All the elapid mature cathelicidins were predicted to be cleaved at Valine157 by elastase. OH-CATH, the deduced mature cathelicidin from king cobra, was chemically synthesized and it showed strong antibacterial activity against various bacteria with minimal inhibitory concentration of 1-20microg/ml in the presence of 1% NaCl. Meanwhile, the synthetic peptide showed no haemolytic activity toward human red blood cells even at a high dose of 200microg/ml. Phylogenetic analysis of cathelicidins from vertebrate suggested that elapid and viperid cathelicidins were grouped together in the tree. Snake cathelicidins were evolutionary closely related to the neutrophilic granule proteins (NGPs) from mouse, rat and rabbit. Snake cathelicidins also showed a close relationship with avian fowlicidins (1-3) and chicken myeloid antimicrobial peptide 27. Elapid cathelicidins might be used as models for the development of novel therapeutic drugs.

New and already known acanthocephalans from amphibians and reptiles in Vietnam, with keys to species of Pseudoacanthocephalus Petrochenko, 1956 (Echinorhynchidae) and Sphaerechinorhynchus Johnston and Deland, 1929 (Plagiorhynchidae).

PubMed

Amin, Omar M; Ha, Ngyuen Van; Heckmann, Richard A

2008-02-01

Adults of 2 new species in 2 orders of acanthocephalans obtained from the intestines of terrestrial amphibians and reptiles collected between 1998 and 2004 in Vietnam are described here. Pseudoacanthocephalus nguyenthileae n. sp. (Palaeacnthocephala: Echinorhynchidae) was collected from 5 species of terrestrial amphibians: (1) the common Sunda toad Bufo melanostictus Schneider (Bufonidae); (2) Paa verucospinosa (Bourret); (3) Gunther's Amoy frog Rana guentheri Boulenger; (4) Taipei frog R. taipehensis Denburgh (Ranidae), and (5) the Burmese whipping frog Polypedates mutus (Smith) (Racophoridae); as well as from the Chinese cobra Naja atra Cantor (Reptilia: Elapidae) and house gecko Hemidactylus frenatus Dumeril and Bibron (Reptilia: Gekkonidae). Sphaerechinorhynchus maximesospinus n. sp. (Plagiorhynchidae: Sphaerechinorhynchinae) was isolated from a king cobra Ophiophagus hannah (cantor) (Reptilia: Elapidae). Cystacanths of Porrorchis houdemeri (Joyeux and Baer, 1935) Schmidt and Kuntz, 1967 (Plagiorhynchidae: Porrorchinae) obtained from the mesenteries of banded krait Bungarus fasciatus (Schneider) (Reptilia: Elapidae), a paratenic host, are reported for the first time. Keys to the species of Pseudoacanthocephalus and Sphaerechinorhynchus are included. Characteristic features distinguishing the new species from related taxa include: P. nguyenthileae has 15-19 (usually 16-18) proboscis hook rows, each with 5-6 hooks that progressively increase in length and size posteriorly. The largest, intermediate, and smallest proboscis hooks of S. maximesospinus are the middle, anterior, and posterior hooks, respectively; the proboscis and neck are enclosed in a membrane. Morphometric characteristics of P. nguyenthileae show host-related variability.

The history of vaccinations in the light of the autism epidemic.

PubMed

Cave, Stephanie F

2008-01-01

Autism has been characterized as a behavioral disorder since it was first described by Leo Kanner in 1943. The number of autistic children has increased over the last decade. The incidence of autism was 1 in 10000 before the 1970s and has steadily increased to 1 in 150 in 2008 with a male:female predominance of 4:1. The cause of this epidemic has remained unknown, but several hypotheses have been studied. Many of these suggest an environmental trigger, such as the ethyl mercury contained in the preservative thimerosal, which has been used in vaccines since 1931. Other possible triggers associated with vaccinations are chemical toxins and live viruses. James has published studies suggesting a genetic predisposition in the families of autistic children, exposing them to a deficiency in glutathione and an inability to detoxify heavy metals. Vargas has shown autism to encompass ongoing inflammation in the brains of autistic children. The Hannah Poling vaccine decision was a landmark case. Poling's family was awarded funds for ongoing medical care of an autistic child who was found to have mitochondrial dysfunction exacerbated by vaccines that left her with autistic behavior and seizures. Several studies have emerged supporting the fact that a significant number of autistic children do have mitochondrial dysfunction. The impact that the Poling case will have on the ability of parents of autistic children to gain access to funds to enable them to properly care for their children remains to be seen.

The challenges and future of oral drug delivery: An interview with David Brayden.

PubMed

Brayden, David J

2016-12-01

David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute. Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research's in vitro pharmacology laboratory in Dublin (1991). At Elan, he became a senior scientist and project manager of several of Elan's joint-venture drug delivery research collaborations with US biotech companies. In 2001, he joined UCD as a lecturer in veterinary pharmacology and was appointed Associate Professor in 2006 and Full Professor in 2014. He was a Director of the Science Foundation Ireland Research Cluster (The Irish Drug Delivery Research Network) from 2007 to 2013, is a Deputy Coordinator of an FP7 Consortium on oral peptides in nanoparticles ('TRANS-INT', 2012-2017), and is a Co-Principal Investigator in 'CURAM', Science Foundation Ireland's new Centre for Medical Devices (2014-2020 [ 1 ]). He was made a Fellow of the Controlled Release Society in 2012. He is the author or co-author of >200 research publications and patents. D Brayden serves on the Editorial Advisory Boards of Drug Discovery Today, European Journal of Pharmaceutical Sciences, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics, and is an Associate Editor of Therapeutic Delivery. D Brayden works as an independent consultant for drug delivery companies.

Subcutaneous Trastuzumab for HER2-positive Breast Cancer – Evidence and Practical Experience in 7 German Centers

PubMed Central

Jackisch, C.; Müller, V.; Dall, P.; Neumeister, R.; Park-Simon, T.-W.; Ruf-Dördelmann, A.; Seiler, S.; Tesch, H.; Ataseven, B.

2015-01-01

A subcutaneous formulation of trastuzumab to treat patients with HER2-positive breast cancer is available since August 2013. The subcutaneous formulation is administered as a fixed dose of 600 mg over a period of up to 5 minutes. The HannaH trial compared subcutaneous with intravenous administration and found comparable pharmacokinetics, efficacy and tolerability for both administration forms of trastuzumab in the neoadjuvant setting. The randomized crossover study PrefHer reported a clear preference from the patientʼs point of view for subcutaneous over intravenous administration of trastuzumab. The accompanying time-and-motion study reported a reduction concerning the total time spent for the institution as well as for the patient receiving trastuzumab s. c.. The experience of 7 German centers largely corresponded with the results of these studies. Patients expressed a clear preference for subcutaneous trastuzumab administration, with the time saved by the subcutaneous administration route cited as the greatest benefit. Although the existing reimbursement terms mean that centers will receive a lower remuneration, the centersʼ overall evaluation of the subcutaneous administration route for trastuzumab was overwhelmingly positive. The greatest benefit cited by the centers was the flexibility in scheduling patient appointments. This increased flexibility improved conditions in some centers which were experiencing pressures due to a shortage of staff, particularly at peak times. The general consensus, however, was that the remuneration systems for oncological treatments urgently need to be amended to ensure that the real costs of treatment are covered, even if the administration route has changed. PMID:26166837

"Perceived age discrimination across age in Europe: From an ageing society to a society for all ages": Correction to Bratt et al. (2018).

PubMed

2018-03-01

Reports an error in "Perceived age discrimination across age in Europe: From an ageing society to a society for all ages" by Christopher Bratt, Dominic Abrams, Hannah J. Swift, Christin-Melanie Vauclair and Sibila Marques ( Developmental Psychology , 2018[Jan], Vol 54[1], 167-180). In the article, the copyright license has been changed to the Creative Commons CC-BY Attribution License. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-47508-001.) Ageism is recognized as a significant obstacle to older people's well-being, but age discrimination against younger people has attracted less attention. We investigate levels of perceived age discrimination across early to late adulthood, using data from the European Social Survey (ESS), collected in 29 countries (N = 56,272). We test for approximate measurement invariance across countries. We use local structural equation modeling as well as moderated nonlinear factor analysis to test for measurement invariance across age as a continuous variable. Using models that account for the moderate degree of noninvariance, we find that younger people report experiencing the highest levels of age discrimination. We also find that national context substantially affects levels of ageism experienced among older respondents. The evidence highlights that more research is needed to address ageism in youth and across the life span, not just old adulthood. It also highlights the need to consider factors that differently contribute to forms of ageism experienced by people at different life stages and ages. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

PubMed Central

Vonk, Freek J.; Casewell, Nicholas R.; Henkel, Christiaan V.; Heimberg, Alysha M.; Jansen, Hans J.; McCleary, Ryan J. R.; Kerkkamp, Harald M. E.; Vos, Rutger A.; Guerreiro, Isabel; Calvete, Juan J.; Wüster, Wolfgang; Woods, Anthony E.; Logan, Jessica M.; Harrison, Robert A.; Castoe, Todd A.; de Koning, A. P. Jason; Pollock, David D.; Yandell, Mark; Calderon, Diego; Renjifo, Camila; Currier, Rachel B.; Salgado, David; Pla, Davinia; Sanz, Libia; Hyder, Asad S.; Ribeiro, José M. C.; Arntzen, Jan W.; van den Thillart, Guido E. E. J. M.; Boetzer, Marten; Pirovano, Walter; Dirks, Ron P.; Spaink, Herman P.; Duboule, Denis; McGlinn, Edwina; Kini, R. Manjunatha; Richardson, Michael K.

2013-01-01

Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of a venomous snake, the king cobra (Ophiophagus hannah), and compared it, together with our unique transcriptome, microRNA, and proteome datasets from this species, with data from other vertebrates. In contrast to the platypus, the only other venomous vertebrate with a sequenced genome, we find that snake toxin genes evolve through several distinct co-option mechanisms and exhibit surprisingly variable levels of gene duplication and directional selection that correlate with their functional importance in prey capture. The enigmatic accessory venom gland shows a very different pattern of toxin gene expression from the main venom gland and seems to have recruited toxin-like lectin genes repeatedly for new nontoxic functions. In addition, tissue-specific microRNA analyses suggested the co-option of core genetic regulatory components of the venom secretory system from a pancreatic origin. Although the king cobra is limbless, we recovered coding sequences for all Hox genes involved in amniote limb development, with the exception of Hoxd12. Our results provide a unique view of the origin and evolution of snake venom and reveal multiple genome-level adaptive responses to natural selection in this complex biological weapon system. More generally, they provide insight into mechanisms of protein evolution under strong selection. PMID:24297900

Using regression analysis to predict emergency patient volume at the Indianapolis 500 mile race.

PubMed

Bowdish, G E; Cordell, W H; Bock, H C; Vukov, L F

1992-10-01

Emergency physicians often plan and provide on-site medical care for mass gatherings. Most of the mass gathering literature is descriptive. Only a few studies have looked at factors such as crowd size, event characteristics, or weather in predicting numbers and types of patients at mass gatherings. We used regression analysis to relate patient volume on Race Day at the Indianapolis Motor Speedway to weather conditions and race characteristics. Race Day weather data for the years 1983 to 1989 were obtained from the National Oceanic and Atmospheric Administration. Data regarding patients treated on 1983 to 1989 Race Days were obtained from the facility hospital (Hannah Emergency Medical Center) data base. Regression analysis was performed using weather factors and race characteristics as independent variables and number of patients seen as the dependent variable. Data from 1990 were used to test the validity of the model. There was a significant relationship between dew point (which is calculated from temperature and humidity) and patient load (P less than .01). Dew point, however, failed to predict patient load during the 1990 race. No relationships could be established between humidity, sunshine, wind, or race characteristics and number of patients. Although higher dew point was associated with higher patient load during the 1983 to 1989 races, dew point was a poor predictor of patient load during the 1990 race. Regression analysis may be useful in identifying relationships between event characteristics and patient load but is probably inadequate to explain the complexities of crowd behavior and too simplified to use as a prediction tool.

Spotlight: David Wood, MD, MSc, FRCP, FESC. A journey from a remote area of Scotland to the capital of the United Kingdom. Interview by Hannah Brown.

PubMed

Wood, David

2007-12-04

The death of an ambulance driver prompted David Wood, MD, MSc, FRCP, FESC, now Garfield Weston Professor of Cardiovascular Medicine at Imperial College, London, United Kingdom, to pursue cardiology as a career.

How readers understand causal and correlational expressions used in news headlines.

PubMed

Adams, Rachel C; Sumner, Petroc; Vivian-Griffiths, Solveiga; Barrington, Amy; Williams, Andrew; Boivin, Jacky; Chambers, Christopher D; Bott, Lewis

2017-03-01

[Correction Notice: An Erratum for this article was reported in Vol 23(1) of Journal of Experimental Psychology: Applied (see record 2016-59631-001). In the article, the fourth author was inadvertently omitted from the advance online version. Also, the second paragraph of the author note should have included the following: "Amy Barrington contributed to the design and data collection for Experiments 2 and 3. We thank the following undergraduate students for contributions to Experiment 1 and pilot work leading up to the project: Laura Benjamin, Cecily Donnelly, Cameron Dunlop, Rebecca Emerson, Rose Fisher, Laura Jones, Olivia Manship, Hannah McCarthy, Naomi Scott, Eliza Walwyn-Jones, Leanne Whelan, and Joe Wilton." All versions of this article have been corrected.] Science-related news stories can have a profound impact on how the public make decisions. The current study presents 4 experiments that examine how participants understand scientific expressions used in news headlines. The expressions concerned causal and correlational relationships between variables (e.g., "being breast fed makes children behave better"). Participants rated or ranked headlines according to the extent that one variable caused the other. Our results suggest that participants differentiate between 3 distinct categories of relationship: direct cause statements (e.g., "makes," "increases"), which were interpreted as the most causal; can cause statements (e.g., "can make," "can increase"); and moderate cause statements (e.g., "might cause," "linked," "associated with"), but do not consistently distinguish within the last group despite the logical distinction between cause and association. On the basis of this evidence, we make recommendations for appropriately communicating cause and effect in news headlines. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Functional proteomic approach to discover geographic variations of king cobra venoms from Southeast Asia and China.

PubMed

Chang, Hui-Ching; Tsai, Tein-Shun; Tsai, Inn-Ho

2013-08-26

This study deciphers the geographic variations of king cobra (Ophiophagus hannah) venom using functional proteomics. Pooled samples of king cobra venom (abbreviated as Ohv) were obtained from Indonesia, Malaysia, Thailand, and two provinces of China, namely Guangxi and Hainan. Using two animal models to test and compare the lethal effects, we found that the Chinese Ohvs were more fatal to mice, while the Southeast Asian Ohvs were more fatal to lizards (Eutropis multifasciata). Various phospholipases A2 (PLA2s), three-finger toxins (3FTxs) and Kunitz-type inhibitors were purified from these Ohvs and compared. Besides the two Chinese Ohv PLA2s with known sequences, eight novel PLA2s were identified from the five Ohv samples and their antiplatelet activities were compared. While two 3FTxs (namely oh-55 and oh-27) were common in all the Ohvs, different sets of 3FTx markers were present in the Chinese and Southeast Asian Ohvs. All the Ohvs contain the Kunitz inhibitor, OH-TCI, while only the Chinese Ohvs contain the inhibitor variant, Oh11-1. Relative to the Chinese Ohvs which contained more phospholipases, the Southeast Asian Ohvs had higher metalloproteinase, acetylcholine esterase, and alkaline phosphatase activities. Remarkable variations in five king cobra geographic samples reveal fast evolution and dynamic translational regulation of the venom which probably adapted to different prey ecology as testified by the lethal tests on mice and lizards. Our results predict possible variations of the king cobra envenoming to human and the importance of using local antivenin for snakebite treatment. Copyright © 2013 Elsevier B.V. All rights reserved.

Effects of bilateral vestibular nucleus lesions on cardiovascular regulation in conscious cats.

PubMed

Mori, R L; Cotter, L A; Arendt, H E; Olsheski, C J; Yates, B J

2005-02-01

The vestibular system participates in cardiovascular regulation during postural changes. In prior studies (Holmes MJ, Cotter LA, Arendt HE, Cas SP, and Yates BJ. Brain Res 938: 62-72, 2002, and Jian BJ, Cotter LA, Emanuel BA, Cass SP, and Yates BJ. J Appl Physiol 86: 1552-1560, 1999), transection of the vestibular nerves resulted in instability in blood pressure during nose-up body tilts, particularly when no visual information reflecting body position in space was available. However, recovery of orthostatic tolerance occurred within 1 wk, presumably because the vestibular nuclei integrate a variety of sensory inputs reflecting body location. The present study tested the hypothesis that lesions of the vestibular nuclei result in persistent cardiovascular deficits during orthostatic challenges. Blood pressure and heart rate were monitored in five conscious cats during nose-up tilts of varying amplitude, both before and after chemical lesions of the vestibular nuclei. Before lesions, blood pressure remained relatively stable during tilts. In all animals, the blood pressure responses to nose-up tilts were altered by damage to the medial and inferior vestibular nuclei; these effects were noted both when animals were tested in the presence and absence of visual feedback. In four of the five animals, the lesions also resulted in augmented heart rate increases from baseline values during 60 degrees nose-up tilts. These effects persisted for longer than 1 wk, but they gradually resolved over time, except in the animal with the worst deficits. These observations suggest that recovery of compensatory cardiovascular responses after loss of vestibular inputs is accomplished at least in part through plastic changes in the vestibular nuclei and the enhancement of the ability of vestibular nucleus neurons to discriminate body position in space by employing nonlabyrinthine signals.

A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa.

PubMed

Thakur, Rupamoni; Kumar, Ashok; Bose, Biplab; Panda, Dulal; Saikia, Debashree; Chattopadhyay, Pronobesh; Mukherjee, Ashis K

2014-10-01

Compounds showing dual inhibition of thrombin and factor Xa (FXa) are the subject of great interest owing to their broader specificity for effective anticoagulation therapy against cardiovascular disorders. This is the first report on the functional characterization and assessment of therapeutic potential of a 4423.6 Da inhibitory peptide (Ruviprase) purified from Daboia russelii russelii venom. The secondary structure of Ruviprase is composed of α-helices (61.9%) and random coils (38.1%). The partial N-terminal sequence (E(1)-V(2)-X(3)-W(4)-W(5)-W(6)-A(7)-Q(8)-L(9)-S(10)) of Ruviprase demonstrated significant similarity (80.0%) with an internal sequence of apoptosis-stimulating protein reported from the venom of Ophiophagus hannah and Python bivittatus; albeit Ruviprase did not show sequence similarity with existing thrombin/FXa inhibitors, suggesting its uniqueness. Ruviprase demonstrated a potent in vitro anticoagulant property and inhibited both thrombin and FXa following slow binding kinetics. Ruviprase inhibited thrombin by binding to its active site via an uncompetitive mechanism with a Ki value and dissociation constant (KD) of 0.42 μM and 0.46 μM, respectively. Conversely, Ruviprase demonstrated mixed inhibition (Ki = 0.16 μM) of FXa towards its physiological substrate prothrombin. Furthermore, the biological properties of Ruviprase could not be neutralized by commercial polyvalent or monovalent antivenom. Ruviprase at a dose of 2.0 mg/kg was non-toxic and showed potent in vivo anticoagulant activity after 6 h of intraperitoneal treatment in mice. Because of the potent anticoagulant property as well as non-toxic nature of Ruviprase, the possible application of the peptide as an antithrombotic agent for combating thrombosis-associated ailments appears promising. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Hepatozoon and Theileria species detected in ticks collected from mammals and snakes in Thailand.

PubMed

Sumrandee, Chalao; Baimai, Visut; Trinachartvanit, Wachareeporn; Ahantarig, Arunee

2015-04-01

We report the detection of Hepatozoon and Theileria in 103 ticks from mammals and snakes in Thailand. By using a genus-specific 18S rRNA PCR, Hepatozoon and Theileria spp. were detected in 8% and 18%, respectively, of ticks (n=79) removed from mammals. Of the ticks removed from snakes (n=24), 96% were infected with Hepatozoon spp., but none were infected with Theileria. Phylogenetic analysis revealed that Hepatozoon spp. detected from Dermacentor astrosignatus and Dermacentor auratus ticks from Wild boar (Sus scrofa) formed a phylogenetic group with many isolates of Hepatozoon felis that were distantly related to a species group containing Hepatozoon canis and Hepatozoon americanum. In contrast, a phylogenetic analysis of the Hepatozoon sequences of snake ticks revealed that Hepatozoon spp. from Amblyomma varanense from King cobra (Ophiophagus hannah) and Amblyomma helvolum ticks from Indochinese rat snake (Ptyas korros), and Asiatic water snake (Xenochrophis piscator) are grouped with Hepatozoon spp. recently isolated from Monocellate cobras, Reticulated pythons and Burmese pythons, all of Thai origin, and with Hepatozoon sp. 774c that has been detected from a tick species obtained from Argus monitors in Australia. A phylogenetic analysis demonstrated that Theileria spp. from Rhipicephalus (Boophilus) microplus, Haemaphysalis obesa, and Haemaphysalis lagrangei ticks from Sambar deer (Cervus unicolor) cluster with the Theileria cervi isolates WU11 and 239, and Theileria sp. Iwate 141. We report for the first time a Hepatozoon species that shares genetic similarity with Hepatozoon felis found in Dermacentor astrosignatus and Dermacentor auratus ticks collected from Wild boars in Thailand. In addition, we found the presence of a Theileria cervi-like sp. which suggests the potential role of Haemaphysalis lagrangei as a Theileria vector in Thailand. Copyright © 2015 Elsevier GmbH. All rights reserved.

The Leadership Efficacy of Graduates of North Carolina School of Science and Mathematics: A Mixed-Methods Analysis

NASA Astrophysics Data System (ADS)

Mason, Letita Renee

This study examines the leadership efficacy amongst graduates of NCSSM from the classes of 2000--07 as the unit of analysis. How do NCSSM graduates' perceptions of their leadership efficacy align with research on non-cognitive variables as indicators of academic performance using the unit of analysis as a performance outcome? This study is based on the theoretical construct that non-cognitive psychological (also called motivational) factors are core components of leadership self-efficacy, indicative of NCSSM graduates (who had high academic performance and attained STEM degrees). It holds promise for increasing both student interest and diversity in the race to strengthen the STEM pipeline. In this study the Hannah and Avolio (2013) Mind Garden Leadership Efficacy Questionnaire (LEQ) is used. The LEQ is a battery of three instruments designed to assess individual perceptions of personal leadership efficacy across three constructs, via one survey tool. In this mixed-methods analysis, a quantitative phase was conducted to collect the data captured by the Mind Garden Leadership Efficacy Questionnaire. A Post Hoc qualitative analysis was conducted in the second phase of the data analysis, using the Trichotomous-Square Test methodology (with an associated qualitative researcher-designed Inventive Investigative Instrument). The results from the study validated the alternative hypothesis [H1], which proposed that there no are significant differences in the perception of the Leadership Efficacy by the North Carolina School of Science and Mathematics Alumni from the classes of 2000-07 in terms of their overall "Leadership Efficacy" in regards to: Execution or "Leadership Action Efficacy"; Capacity or "Leader Means Efficacy"; and Environment or "Leader Self-Regulation Efficacy" was accepted. The results also led to the development of a new assessment tool called the Mason Leadership Efficacy Model.

Recommendations to enable drug development for inherited neuropathies: Charcot-Marie-Tooth and Giant Axonal Neuropathy

PubMed Central

Sames, Lori; Moore, Allison; Arnold, Renee; Ekins, Sean

2014-01-01

Approximately 1 in 2500 Americans suffer from Charcot-Marie-Tooth (CMT) disease. The underlying disease mechanisms are unique in most forms of CMT, with many point mutations on various genes causing a toxic accumulation of misfolded proteins. Symptoms of the disease often present within the first two decades of life, with CMT1A patients having reduced compound muscle and sensory action potentials, slow nerve conduction velocities, sensory loss, progressive distal weakness, foot and hand deformities, decreased reflexes, bilateral foot drop and about 5% become wheelchair bound. In contrast, the ultra-rare disease Giant Axonal Neuropathy (GAN) is frequently described as a recessively inherited condition that results in progressive nerve death. GAN usually appears in early childhood and progresses slowly as neuronal injury becomes more severe and leads to death in the second or third decade. There are currently no treatments for any of the forms of CMTs or GAN. We suggest that further clinical studies should analyse electrical impedance myography as an outcome measure for CMT. Further, additional quality of life (QoL) assessments for these CMTs are required, and we need to identify GAN biomarkers as well as develop new genetic testing panels for both diseases. We propose that using the Global Registry of Inherited Neuropathy (GRIN) could be useful for many of these studies. Patient advocacy groups and professional organizations (such as the Hereditary Neuropathy Foundation (HNF), Hannah's Hope Fund (HHF), The Neuropathy Association (TNA) and the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) can play a central role in educating clinicians and patients. Undertaking these studies will assist in the correct diagnosis of disease recruiting patients for clinical studies, and will ultimately improve the endpoints for clinical trials. By addressing obstacles that prevent industry investment in various forms of inherited neuropathies, we can

"Was für Grün in der Stadt?". Politische Aushandlungsprozesse um städtische Grün- und Freiräume am Beispiel des urbanen Gärtnerns in Schweizer Städten

NASA Astrophysics Data System (ADS)

Klöti, Tanja; Tappert, Simone; Drilling, Matthias

2016-06-01

Urban green space is a key subject of actual urban negotiation processes on how the city shall develop. Visions of the ideal city are reflected in the meanings currently ascribed to urban gardening. Thereby the relation between human and nature as well as between build and natural environment in the city plays a central role. Results from different Swiss cities show that allotment gardens as well as newer forms of urban gardening are oscillating between a compensatory and a complementary understanding of nature, and they equally combine the desire for pristine nature with the demand for functional green space in the city.

Constraining Runoff Source Fraction Contributions from Alpine Glaciers through the Combined Application of Geochemical Proxies and Bayesian Monte Carlo Isotope Mixing Models

NASA Astrophysics Data System (ADS)

Arendt, C. A.; Aciego, S.; Hetland, E.

2015-12-01

Processes that drive glacial ablation directly impact surrounding ecosystems and communities that are dependent on glacial meltwater as a freshwater reservoir: crucially, freshwater runoff from alpine and Arctic glaciers has large implications for watershed ecosystems and contingent economies. Furthermore, glacial hydrology processes are a complex and fundamental part of understanding high-latitude environments in the modern and predicting how they might change in the future. Specifically, developing better estimates of the origin of freshwater discharge, as well as the duration and amplitude of extreme melting and precipitation events, could provide crucial constraints on these processes and allow for glacial watershed systems to be modeled more effectively. In order to investigate the universality of the temporal and spatial melt relationships that exist in glacial systems, I investigate the isotopic composition of glacial meltwater and proximal seawater including stable isotopes δ18O and δD, which have been measured in glacial water samples I collected from the alpine Athabasca Glacier in the Canadian Rockies. This abstract is focused on extrapolating the relative contributions of meltwater sources - snowmelt, ice melt, and summer precipitation - using a coupled statistical-chemical model (Arendt et al., 2015). I apply δ18O and δD measurements of Athabasca Glacier subglacial water samples to a Bayesian Monte Carlo (BMC) estimation scheme. Importantly, this BMC model also assesses the uncertainties associated with these meltwater fractional contribution estimations, which provides an assessment of how well the system is constrained. By defining the proportion of overall melt that is coming from snow versus ice using stable isotopes, the volume of water generated by ablation can be calculated. This water volume has two important implications. First, communities that depend on glacial water for aquifer recharge can start assessing future water resources, as

"Was Lietz padagogisch erstrebte, hat Hitler politisch durchgesetzt". Schulreformerische Traditionen und nationalsozialistische Schulpolitik in Thuringen" ("The Pedagogical Intentions of Lietz Were Enforced Politically by Hitler". Traditions of School Reform and National Socialist School Policy in Thuringia).

ERIC Educational Resources Information Center

Lesanovsky, Werner

1998-01-01

Inquires of the regional effects of National Socialist school policy, using as an example Thuringia (Germany), the educational landscape of which is traditionally characterized by reform-oriented institutions. Reveals how streamlining of reform schools and instruction from the top and self-streamlining from the bottom ran parallel after 1933. (CMK)

"How readers understand causal and correlational expressions used in news headlines": Correction to Adams et al. (2016).

PubMed

2017-03-01

Reports an error in "How Readers Understand Causal and Correlational Expressions Used in News Headlines" by Rachel C. Adams, Petroc Sumner, Solveiga Vivian-Griffiths, Amy Barrington, Andrew Williams, Jacky Boivin, Christopher D. Chambers and Lewis Bott ( Journal of Experimental Psychology: Applied , Advanced Online Publication, Nov 3, 2016, np). In the article, the fourth author was inadvertently omitted from the advance online version. Also, the second paragraph of the author note should have included the following: "Amy Barrington contributed to the design and data collection for Experiments 2 and 3. We thank the following undergraduate students for contributions to Experiment 1 and pilot work leading up to the project: Laura Benjamin, Cecily Donnelly, Cameron Dunlop, Rebecca Emerson, Rose Fisher, Laura Jones, Olivia Manship, Hannah McCarthy, Naomi Scott, Eliza Walwyn-Jones, Leanne Whelan, and Joe Wilton." All versions of this article have been corrected. (The following abstract of the original article appeared in record 2016-52933-001.) Science-related news stories can have a profound impact on how the public make decisions. The current study presents 4 experiments that examine how participants understand scientific expressions used in news headlines. The expressions concerned causal and correlational relationships between variables (e.g., "being breast fed makes children behave better"). Participants rated or ranked headlines according to the extent that one variable caused the other. Our results suggest that participants differentiate between 3 distinct categories of relationship: direct cause statements (e.g., "makes," "increases"), which were interpreted as the most causal; can cause statements (e.g., "can make," "can increase"); and moderate cause statements (e.g., "might cause," "linked," "associated with"), but do not consistently distinguish within the last group despite the logical distinction between cause and association. On the basis of this evidence

Building a Public Health Response to the Flint Water Crisis: Implications for Policy and Decision-Making

NASA Astrophysics Data System (ADS)

Furr-Holden, D.

2017-12-01

Flint, MI has experienced a recent, man-made public health crisis. The Flint Water Crisis, caused by a switch in the municipal water supply and subsequent violation of engineering and regulatory standards to ensure water quality lead to a large portion of the city being exposed to excess metals (including lead), bacteria and other water-borne pathogens. The data used to initially rebut the existence of the crisis were ecologically flawed as they included large numbers of people who were not on the Flint water supply. Policy-makers, municipal officials, the medical community, and public health professionals were at odds over the existence of a problem and the lack of data only fueled the debate. Pediatricians, lead by Dr. Mona Hannah-Attisha, began testing children in the Hurley Children's Medical Center for blood-lead levels and observed a 2-fold increase in elevated blood lead levels in Flint children compared to children in the area not on the Flint municipal water supply, where no increases in elevated lead were observed. Subsequent geospatial analyses revealed spatial clustering of cases based on where children live, go to school and play. These data represented the first step in data driven decision making leading to the subsequent switch of the municipal water supply and launch of subsequent advocacy efforts to remediate the effect of the Water Crisis. Since that time, a multi-disciplinary team of scientists including engineers, bench scientists, physicians and public health researchers have mounted evidence to promote complete replacement of the city's aging water infrastructure, developed a data registry to track cases and coordinate care and services for affected residents, and implemented a community engagement model that puts residents and community stakeholders at the heart of the planning and implementation efforts. The presentation will include data used at various stages to mount a public health response to the Flint Water Crisis and establish the

PREFACE: FAIRNESS 2013: FAIR NExt generation of ScientistS 2013

NASA Astrophysics Data System (ADS)

Petersen, Hannah; Destefanis, Marco; Galatyuk, Tetyana; Montes, Fernando; Nicmorus, Diana; Ratti, Claudia; Tolos, Laura; Vogel, Sascha

2014-04-01

research that is dedicated to the physics of FAIR. February 2014. Organizers of FAIRNESS 2013: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Logos

Climatic Instability and Regional Glacial Advances in the Late Ediacaran

NASA Astrophysics Data System (ADS)

Hannah, J. L.; Stein, H. J.; Marolf, N.; Bingen, B.

2014-12-01

"snowball Earth" event; rather, there may have been multiple Ediacaran glacial advances - perhaps only at high latitudes - marked by tillites of regional, but not global extent. [1] Bowring et al. 2002, Astrobiology 2: 457-458. [2] Shen et al. 2010, Prec. Res. 177: 241-252. [3] Hannah et al. 2007, Geochim. Cosmochim. Acta 71: A378.

Cultural Sensitive Care Provision in a Public Child and Adolescent Mental Health Centre: A Case Study from the Toulouse University Hospital Intercultural Consultation.

PubMed

Sturm, Gesine; Bonnet, Sylvie; Coussot, Yolaine; Journot, Katja; Raynaud, Jean-Philippe

2017-12-01

Child and adolescent mental health services in Europe are confronted with children with increasingly diverse socio-cultural backgrounds. Clinicians encounter cultural environments of hyperdiversity in terms of languages and countries of origin, growing diversity within groups, and accelerated change with regards to social and administrational situations (Hannah, in: DelVecchio Good et al. (eds) Shattering culture: American medicine responds to cultural diversity, Russel Sage Foundation, New York, 2011). Children and families who live in these complex constellations face multiple vulnerabilizing factors related to overlapping or intersecting social identities (Crenshaw in Univ Chic Leg Forum 140:139-167, 1989). Mobilizing existing resources in terms of social and family support, and encouraging creative strategies of interculturation in therapeutic work (Denoux, in: Blomart and Krewer (eds) Perspectives de l'interculturel, L'Harmattan, Paris, 1994) may be helpful in order to enhance resilience. Drawing from experiences in the context of French transcultural and intercultural psychiatry, and inspired by the Mc Gill Cultural Consultation in Child Psychiatry, we developed an innovative model, the Intercultural Consultation Service (ICS). This consultation proposes short term interventions to children and families with complex migration experiences. It has been implemented into a local public health care structure in Toulouse, the Medical and Psychological Centre la Grave. The innovation includes the creation of a specific setting for short term therapeutic interventions and team training via shared case discussions. Our objectives are (a) to improve outcomes of mental health care for the children through a better understanding of the child's family context (exploration of family dynamics and their relatedness to complex migration histories), (b) to enhance intercultural competencies in professionals via shared case discussions, and, (c) to improve the therapeutic

The detection of hemorrhagic proteins in snake venoms using monoclonal antibodies against Virginia opossum (Didelphis virginiana) serum.

PubMed

Sánchez, E E; García, C; Pérez, J C; De La Zerda, S J

1998-10-01

, reacted with all the hemorrhagic venoms except for the venom of the King cobra (Ophiophagus hannah) and did not react with the non-hemorrhagic venoms. The hemorrhagic binding site of CAH monoclonal antibody and the antihemorrhagin in Virginia opossum are different binding sites. The five-step western blot will be a very useful assay for determining hemorrhagic activity without using live animals.

PREFACE: Hot Quarks 2012: Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions

NASA Astrophysics Data System (ADS)

Bleicher, Markus; Caines, Helen; Calderón de la Barca Sanchez, Manuel; Fries, Rainer; Granier de Cassagnac, Raphaël; Hippolyte, Boris; Mischke, André; Mócsy, Ágnes; Petersen, Hannah; Ruan, Lijuan; Salgado, Carlos A.

2013-09-01

Laboratory USAUSA Manuel Calderón de la Barca SánchezHannah Petersen UC DavisFIAS USAGermany Rainer J FriesLijuan Ruan Texas A&M UniversityBrookhaven National Laboratory USAUSA Raphaël Granier de CassagnacCarlos A Salgado CNRS-IN2P3 and Ëcole polytechniqueUniversidade de Santiago de Compostela FranceSpain Boris Hippolyte CNRS-IN2P3 and Université de Strasbourg France The PDF also contains the conference poster.

PREFACE: Hot Quarks 2014: Workshop for young scientists on the physics of ultrarelativistic nucleus-nucleus collisions

NASA Astrophysics Data System (ADS)

2015-05-01

) Boris Hippolyte, CNRS-IN2P3 and Université de Strasbourg (France) Jiangyong Jia, Stony Brook University and Brookhaven National Laboratory (USA) André Mischke, Utrecht University and Nikhef Amsterdam (The Netherlands) Ágnes Mócsy, Pratt Institute and Brookhaven National Laboratory (USA) Hannah Petersen, Goethe University, FIAS and GSI (Germany) Lijuan Ruan, Brookhaven National Laboratory (USA) Sevil Salur, Rutgers University, (USA)

PREFACE: FAIRNESS 2014: FAIR Next Generation ScientistS 2014

NASA Astrophysics Data System (ADS)

2015-04-01

is dedicated to the physics at FAIR. February 2015, Organizers of FAIRNESS 2014: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Conference photograph

Evaluation of Diet-Related Infographics on Pinterest for Use of Behavior Change Theories: A Content Analysis.

PubMed

Wilkinson, Jessica L; Strickling, Kate; Payne, Hannah E; Jensen, Kayla C; West, Joshua H

2016-12-08

order to portray elements of HBT and convey nutritional information. ©Jessica L Wilkinson, Kate Strickling, Hannah E Payne, Kayla C Jensen, Joshua H West. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 08.12.2016.

PREFACE: FAIRNESS 2012: FAIR NExt Generation of ScientistS 2012

NASA Astrophysics Data System (ADS)

Arcones, Almudena; Bleicher, Marcus; Fritsch, Miriam; Galatyuk, Tetyana; Nicmorus, Diana; Petersen, Hannah; Ratti, Claudia; Tolos, Laura

2013-03-01

forefront of research that is dedicated to the physics of FAIR. February 2013, Organizers of FAIRNESS 2012: Almudena Arcones, Marcus Bleicher, Miriam Fritsch, Tetyana Galatyuk, Diana Nicmorus, Hannah Petersen, Claudia Ratti and Laura Tolos Support for holding the conference was provided by: logos

Intensities of drilling predation of molluscan assemblages in intertidal and subtidal soft substrates in the Persian (Arabian) Gulf

NASA Astrophysics Data System (ADS)

Handler, Sabine M.; Albano, Paolo G.; Bentlage, Rudolf; Drummond, Hannah; García-Ramos, Diego A.; Zuschin, Martin

2016-04-01

Intensities of drilling predation of molluscan assemblages in intertidal and subtidal soft substrates in the Persian (Arabian) Gulf Sabine Maria Handler1, Paolo G. Albano1, Rudolf Bentlage2, Hannah Drummond2, D.A. García-Ramos1, Martin Zuschin1 1 Department of Paleontology, University of Vienna, Austria 2 St. Lawrence University, Canton, New York 13617, USA Trace fossils left by predators in the skeleton of their prey are arguably one of the most powerful sources of direct data on predator-prey interactions available in the fossil record. Drill holes, especially those attributed to naticid and muricid gastropods, are unambiguous marks of predation and allow discriminating between successful and unsuccessful predation attempts (complete and incomplete holes, respectively). Latitude and water depth influence drilling frequency. We inspected death assemblages of an intertidal flat and of two subtidal (water depth between 6 and 20 m) sandy sites in the Persian (Arabian) Gulf, off the coast of the United Arab Emirates, to determine the patterns of predation on shelled molluscs along the depth gradient. The study is based on ~7,000 and ~60,000 shells from the intertidal and subtidal, respectively. Drilling Frequency (DF, the number of drilled individuals), Incomplete Drilling Frequency (IDF, number of incomplete drill holes), and Prey Effectiveness (ratio between the number of incomplete drill holes and the total number of drilling attempts) were used as metrics of drilling intensity. We observed major differences between the intertidal and subtidal study areas. Drilling frequencies were generally remarkably low and intertidal flats showed a much lower drilling frequency than the subtidal (1.4% and 6.7%, respectively). In the subtidal, we observed significant differences of drilling intensity among bivalve species and between the two sites. However, predation metrics did not correlate with environmental factors such as substrate type and depth, nor with species life

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study.

PubMed

Dewey, Rebecca Susan; Hall, Deborah A; Guest, Hannah; Prendergast, Garreth; Plack, Christopher J; Francis, Susan T

2018-03-09

procedures for hidden hearing loss, enabling early identification of noise-induced auditory damage via the detection of changes in central auditory processing. Consequently, this will generate the opportunity to give personalized advice regarding provision of ear defense and monitoring of further damage, thus reducing the incidence of noise-induced hearing loss. ©Rebecca Susan Dewey, Deborah A Hall, Hannah Guest, Garreth Prendergast, Christopher J Plack, Susan T Francis. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 09.03.2018.

MEDEX2015: Greater Sea-Level Fitness Is Associated with Lower Sense of Effort During Himalayan Trekking Without Worse Acute Mountain Sickness.

PubMed

Rossetti, Gabriella M K; Macdonald, Jamie H; Smith, Matthew; Jackson, Anna R; Callender, Nigel; Newcombe, Hannah K; Storey, Heather M; Willis, Sebastian; van den Beukel, Jojanneke; Woodward, Jonathan; Pollard, James; Wood, Benjamin; Newton, Victoria; Virian, Jana; Haswell, Owen; Oliver, Samuel J

2017-06-01

Rossetti, Gabriella M.K., Jamie H. Macdonald, Matthew Smith, Anna R. Jackson, Nigel Callender, Hannah K. Newcombe, Heather M. Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, and Samuel J. Oliver. MEDEX2015: Greater sea-level fitness is associated with lower sense of effort during Himalayan trekking without worse acute mountain sickness. High Alt Med Biol. 18:152-162, 2017.-This study examined the complex relationships of fitness and hypoxic sensitivity with submaximal exercise responses and acute mountain sickness (AMS) at altitude. Determining these relationships is necessary before fitness or hypoxic sensitivity tests can be recommended to appraise individuals' readiness for altitude. Forty-four trekkers (26 men; 18 women; 20-67 years) completed a loaded walking test and a fitness questionnaire in normoxia to measure and estimate sea-level maximal aerobic capacity (maximum oxygen consumption [[Formula: see text]O 2max ]), respectively. Participants also completed a hypoxic exercise test to determine hypoxic sensitivity (cardiac, ventilatory, and arterial oxygen saturation responses to acute hypoxia, fraction of inspired oxygen [Fio 2 ] = 0.112). One month later, all participants completed a 3-week trek to 5085 m with the same ascent profile. On ascent to 5085 m, ratings of perceived exertion (RPE ascent ), fatigue by Brunel Mood Scale, and AMS were recorded daily. At 5085 m, RPE during a fixed workload step test (RPE fixed ) and step rate during perceptually regulated exercise (STEP RPE35 ) were recorded. Greater sea-level [Formula: see text]O 2max was associated with, and predicted, lower sense of effort (RPE ascent ; r = -0.43; p < 0.001; RPE fixed ; r = -0.69; p < 0.001) and higher step rate (STEP RPE35 ; r = 0.62; p < 0.01), but not worse AMS (r = 0.13; p = 0.4) or arterial oxygen desaturation (r = 0.07; p = 0

Paramedic Checklists do not Accurately Identify Post-ictal or Hypoglycaemic Patients Suitable for Discharge at the Scene.

PubMed

Tohira, Hideo; Fatovich, Daniel; Williams, Teresa A; Bremner, Alexandra; Arendts, Glenn; Rogers, Ian R; Celenza, Antonio; Mountain, David; Cameron, Peter; Sprivulis, Peter; Ahern, Tony; Finn, Judith

2016-06-01

to hypoglycemia. The checklists did not accurately identify patients suitable for discharge at the scene within the Emergency Medical Service. Patients who fulfilled the post-ictal checklist made more subsequent health care service requests within three days than those who did not. Both checklists showed similar occurrence of subsequent events to paramedics' decision, but the hypoglycemia checklist identified fewer patients who could be discharged at the scene than paramedics actually discharged. Reliance on these checklists may increase transportations to ED and delay initiation of appropriate treatment at a hospital. Tohira H , Fatovich D , Williams TA , Bremner A , Arendts G , Rogers IR , Celenza A , Mountain D , Cameron P , Sprivulis P , Ahern T , Finn J . Paramedic checklists do not accurately identify post-ictal or hypoglycaemic patients suitable for discharge at the scene. Prehosp Disaster Med. 2016;31(3):282-293.

IntelliCare: An Eclectic, Skills-Based App Suite for the Treatment of Depression and Anxiety.

PubMed

Mohr, David C; Tomasino, Kathryn Noth; Lattie, Emily G; Palac, Hannah L; Kwasny, Mary J; Weingardt, Kenneth; Karr, Chris J; Kaiser, Susan M; Rossom, Rebecca C; Bardsley, Leland R; Caccamo, Lauren; Stiles-Shields, Colleen; Schueller, Stephen M

2017-01-05

briefly to reduce symptoms of depression and anxiety. The IntelliCare system is elemental, allowing individual apps to be used or not used based on their effectiveness and utility, and it is eclectic, viewing treatment strategies as elements that can be applied as needed rather than adhering to a singular, overarching, theoretical model. Clinicaltrials.gov NCT02176226; http://clinicaltrials.gov/ct2/show/NCT02176226 (Archived by WebCite at http://www.webcitation/6mQZuBGk1). ©David C Mohr, Kathryn Noth Tomasino, Emily G. Lattie, Hannah L Palac, Mary J Kwasny, Kenneth Weingardt, Chris J Karr, Susan M Kaiser, Rebecca C Rossom, Leland R Bardsley, Lauren Caccamo, Colleen Stiles-Shields, Stephen M Schueller. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 05.01.2017.

Tales of sociology and the nursing curriculum: revisiting the debates.

PubMed

Aranda, Kay; Law, Kate

2007-08-01

The relationship between nursing and sociology has been extensively debated for more than two decades [Cox, C.A., 1979. Who cares? Nursing and sociology: the development of a symbiotic relationship. Journal of Advanced Nursing 4, 237-252; Cooke, H., 1993. Why teach sociology? Nurse Education Today 13, (3) 210-216; Sharpe, K., 1994. Sociology and the nursing curriculum: a note of caution. Journal of Advanced Nursing 20, (2) 391-395; Sharpe, K., 1995. Why indeed should we teach sociology? A response to Hannah Cooke. Nurse Education Today 15, (1) 52-55; Sharpe, K., 1996. Feedback - sociology and the nursing curriculum: a reply to Sam Porter. Journal of Advanced Nursing 23, (7) 1275-1278; Balsamo, D., Martin, S.I., 1995a. Developing the sociology of health in nurse education: towards a more critical curriculum. Part 1. Andragogy and sociology in Project 2000. Nurse Education Today 15, 427-432; Balsamo, D., Martin, S.I., 1995b. Developing the sociology of health in nurse education: towards a more critical curriculum. Part 2. Linking methodology and epistemology. Nurse Education Today 15, 427-432; Porter, S., 1995. Sociology and the nursing curriculum: a defence. Journal of Advanced Nursing 21, (6) 1130-1135; Porter, S., 1996. Why teach sociology? A contribution to the debate. Nurse Education Today, 16, 170-174; Porter, S., 1997. Sociology and the nursing curriculum: a further comment. Journal of Advanced Nursing 26, (1) 214-218; Porter, S., 1998. Social Theory and Nursing Practice. Macmillan, Basingstoke; Corlett, J., 2000. The perceptions of nurse teacher, student nurses and preceptors of the theory-practice gap in nurse education. Nurse Education Today 20, 499-505; Allen, D., 2001. Review article: nursing and sociology: an uneasy marriage?. Sociology of Health and Illness 23, (3) 386-396; Pinikahana, J., 2003. Role of sociology within the nursing enterprise: some reflections on the unfinished debate. Nursing and health Sciences 5, (2) 175-180; Holland, K., 2004

Public Perceptions Regarding Use of Virtual Reality in Health Care: A Social Media Content Analysis Using Facebook.

PubMed

Keller, Michelle Sophie; Park, Hannah J; Cunningham, Maria Elena; Fouladian, Joshua Eleazar; Chen, Michelle; Spiegel, Brennan Mason Ross

2017-12-19

, infection risk, motion sickness, and the ubiquity of and overall dependence on technology. There was a statistically significant association between the language valence of the Facebook post and the gender of the Facebook user; men were more likely to post negative perceptions about the use of VR for health care, whereas women were more likely to post positive perceptions (P<.001). Most informants expressed positive perceptions about the use of VR in a wide range of health care settings. However, many expressed concerns that should be acknowledged and addressed as health care VR continues to evolve. Our results provide guidance in determining where further research on the use of VR in patient care is needed, and offer a formal opportunity for public opinion to shape the VR research agenda. ©Michelle Sophie Keller, Hannah J Park, Maria Elena Cunningham, Joshua Eleazar Fouladian, Michelle Chen, Brennan Mason Ross Spiegel. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.12.2017.

Challenges of citizen science contributions to modelling hydrodynamics of floods

NASA Astrophysics Data System (ADS)

Assumpção, Thaine Herman; Popescu, Ioana; Jonoski, Andreja; Solomatine, Dimitri P.

2017-04-01

. More than that, further work lies in evaluating its contribution for more general settings. One issue is quantifying the scalability of these mechanisms considering, for example: how many citizen observations are needed to achieve significant improvement in a hydrodynamic model? What is the necessary spatial and temporal distribution? Another issue relates to the quality of data: should citizen observatory data be treated the same way as traditional data within models? Is pre quality control enough? The mentioned Citizens Observatory projects are already tackling this problematic, showing that only by facing these challenges the real contribution of citizen science towards modelling the hydrodynamics of floods will be uncovered. Reference: Buytaert, W., Zulkafli, Z., Grainger, S., Acosta, L., Alemie, T. C., Bastiaensen, J., De Bièvre, B., Bhusal, J., Clark, J., Dewulf, A., Foggin, M., Hannah, D. M., Hergarten, C., Isaeva, A., Karpouzoglou, T., Pandeya, B., Paudel, D., Sharma, K., Steenhuis, T., Tilahun, S., Van Hecken, G., and Zhumanova, M.: Citizen science in hydrology and water resources: opportunities for knowledge generation, ecosystem service management, and sustainable development, Front. Earth Sci., 2, 1-4, doi: 10.3389/feart.2014.00026, 2014.

A gallery of oil components, their metals and Re-Os signatures

NASA Astrophysics Data System (ADS)

Stein, Holly J.; Hannah, Judith L.

2016-04-01

H are part of the equation controlling composition of metal-bearing aqueous fluids siphoned from residual hydrocarbons. The Re-Os isotopic behavior of oil components is generally specific to location and may differ within a single oil field, or even within discrete fractions of a single sample of oil [1]. Different fractions in a crude oil, for example maltenes and asphaltenes, can preserve signatures of unique sources. This should not be surprising, since economic geologists have long called upon meeting and mixing of metal-bearing with sulfur-bearing fluids from different sources. A time-integrated geologic history can also be derived from bitumen veins, with the Re-Os age of the metal source cached in these veins. Preservation of early metal and hydrocarbon history, and intact Re-Os systematics preserved in younger-formed systems have enormous potential for the resource industry. Several examples will be presented. [1] Georgiev, S.V., Stein, H.J., Hannah, J.L., Galimberti, R., Nali, M., Yang, G., and Zimmerman, A. (returned post revision, 11 Jan 2016) Re-Os dating of maltenes and asphaltenes within single samples of crude oils: Geochimica et Comochimica Acta. Supported by a consortium of petroleum companies under the CHRONOS project.

Structural Geology and Microstructures of Wrangel Island, Arctic Russia

NASA Astrophysics Data System (ADS)

Miller, E. L.; Dumitru, T. A.; Seward, G.

2010-12-01

Wrangel Island is a unique exposure of Neoproterozoic basement and upper Paleozoic and Mesozoic cover. Its geology is critical for testing the continuity of stratigraphic units and structures across the Chukchi Sea from Alaska to Russia, for constraining paleogeography and plate reconstructions of the Arctic and for evaluating the hydrocarbon potential of this offshore region. The Paleozoic stratigraphy of Wrangel correlates to the offshore Hannah Trough, Alaska, but its thick section of Triassic turbidites has no counterpart in Alaska (Miller et al., 2010, AAPG; Sherwood et al., 2002, GSA Spec. Paper 360). Wrangel Island lies on a regional structural high along strike of the offshore Herald Arch and Chukchi Platform, Alaska. To the north, the deep North Chukchi Basin, bound by ~E-NE trending, north-dipping normal faults, is inferred to contain up to 12 km of Beaufortian and Brookian (Late Jurassic to Tertiary) sediments in addition to Paleozoic strata (Dinkelman et al., 2008). To the south, ~E-W trending faults bound the Longa Basin that separates Wrangel from Chukotka and lies along strike of the early Tertiary Hope Basin. Wrangel Island was interpreted to represent a north-vergent Mesozoic to Tertiary fold and thrust belt traced offshore by seismic reflection to the Herald Arch and then to the Lisburne Hills and the Brooks Range foreland fold and thrust belt, (e.g. Kos’ko et al., 1993). However, deformation of Wrangel Island rocks differs significantly from typical foreland fold-thrust structures. Both cover and basement rocks have strong penetrative metamorphic fabrics. Foliation strikes E-W and dips ~40° S, with a pronounced N-S trending elongation or stretching lineation. Aspect ratios of stretched pebbles are ~ 5:1:.2 to 10:1:.1. The foliation is axial planar to tight/isoclinal folds at all scales and these also involve the basement-sediment contact. 25 oriented thin-sections of feldspathic sandstones and grits were examined for sense of shear and the

Relative foraminiferan abundance as an indicator of seagrass sediment health:

NASA Astrophysics Data System (ADS)

Cajandig, P.; Quiros, A.; Nolan, H.; Tallman, R.; Cooper, N.; Ayala, J.; Courtier, C.

2013-12-01

Authors: Patrick Cajandig*, Jose Ayala**, Nathaniel Cooper**, Catherine Courtier**, Hannah Nolan**, Rachelle Tallman**, T.E. Angela L. Quiros** * Davis High-School CA, **University of California Santa Cruz, Ecology and Evolutionary Biology Department Seagrasses are a key component in coastal ecosystems. Found in shallow marine environments, they make a large contribution to coastal ecosystem health by sustaining water quality, stabilizing the sea bottom, and providing habitat as well as food for other organisms. Seagrasses accumulate tiny grains of sediment, increasing water clarity. Just like barren hills are prone to erosion compared to vegetated, rooted down hills, we find a similar situation in the ocean. Seagrasses have broad roots that extend vertically and horizontally to help stabilize the seabed. Seagrasses support a whole ecosystem, because some organisms feed off of the seagrass alone, while others feed off the inhabitants of the seagrass. The quality of sediment is a vital part of seagrass health, just like nutrient rich soils are important to land plants. But what in seagrass sediment is a good indication of health? We hypothesize that seagrass health measures such as percent cover and seagrass species diversity are related to the abundance of foraminiferans relative to other seagrass sediment components. My mentor, T. E. Angela L. Quiros, from the University of California, Santa Cruz (UCSC), collected the sediment samples from seagrass beds in the Philippines. Samples were dried and brought to UCSC for sediment sieving. We used different sized sieves to sort the sediment. These sieves ranged from coarse to very fine sieves (Phi -2.0 (coarse) through +3.0 (fine) going in 0.5 intervals on a log scale). We weighed the sediment that was caught in each tray and separated them into bags of different size classes. To analyze each sample, we subsampled four size classes (Phi's -2.0, -1.5,-1.0, 0.0), and used a dissecting scope to identify and then weigh the

Generating and Synthesizing Information about Risks in Unconventional Oil and Gas Development

NASA Astrophysics Data System (ADS)

Wiseman, H.

2013-12-01

Hannah Wiseman, Florida State University College of Law Stakeholders, agency staff, and policymakers all need more and better information about the risks of unconventional oil and gas development, including horizontal drilling and hydraulic fracturing. To create more accurate and accessible information in this area, three steps are needed: better production of information about technologies; better production of information about risks; and better synthesis and organization of information. We also must decide who should be primarily responsible for these tasks. First, we must produce information about the technologies involved at each stage of well development. It is impossible to understand the risks without understanding the technologies behind them. When the Bureau of Land Management proposed that all oil and gas operators on BLM lands would have to submit a cement bond log for each well, industry actors argued that cement bond log readings are often unreliable close to the surface due to temperatures and acoustics. Industry has the most knowledge in this area, and government officials need to work with industry to better understand the technology and communicate information about it to the public. This is likely best done by a federal agency: the technologies are, broadly speaking, similar across regions--even for shale oil and gas. To understand and communicate risks we also need better data about risks. Industry actors often have few incentives to share information about known risks, as more data could lead to more regulation. States, who have the most jurisdictional authority over the risks, therefore should require industry to produce limited data. Alternatively, states--or the federal government--must collect this data themselves, as the U.S. Geological Survey has already begun to do for water in oil and gas regions. Specifically, they should require: baseline and post-development testing of surface and underground water sources around well sites before

Trends and determinants of IUD use in the USA, 2002-2012.

PubMed

Mosher, William D; Moreau, Caroline; Lantos, Hannah

2016-08-01

to have children. Dissatisfaction with a previous method was also associated with IUD use (adjusted odds ratio = 1.89, P < 0.001). As with all cross-sectional studies, causal inference is limited. Data are self-reported, but the survey had a high response rate and rigorous quality controls. This study shows promising trends in the use of highly effective contraceptive methods in the USA, which may help to explain recently reported declines in unintended pregnancy in the USA. Caroline Moreau was supported by the William Robertson endowment funds. The work of Hannah Lantos and William Mosher on this analysis was supported by the Department of Population Family and Reproductive Health, The Johns Hopkins Bloomberg School of Public Health. The authors declare that no conflict of interest exists. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial.

PubMed

Morris, Rachel K; Malin, Gemma L; Quinlan-Jones, Elisabeth; Middleton, Lee J; Hemming, Karla; Burke, Danielle; Daniels, Jane P; Khan, Khalid S; Deeks, Jon; Kilby, Mark D

2013-11-02

�06-9·62; p=0·03). All 12 deaths were caused by pulmonary hypoplasia in the early neonatal period. Sensitivity analysis in which non-treatment-related terminations of pregnancy were excluded made some slight changes to point estimates only. Bayesian analysis in which the trial data were combined with elicited priors from experts suggested an 86% probability that vesicoamniotic shunting increased survival at 28 days and a 25% probability that it had a large, clinically important effect (defined as a relative increase of 55% or more in the proportion of neonates who survived). There was substantial short-term and long-term morbidity in both groups, including poor renal function-only two babies (both in the shunt group) survived to 2 years with normal renal function. Seven complications occurred in six fetuses from the shunt group, including spontaneous ruptured membranes, shunt blockage, and dislodgement. These complications resulted in four pregnancy losses. Survival seemed to be higher in the fetuses receiving vesicoamniotic shunting, but the size and direction of the effect remained uncertain, such that benefit could not be conclusively proven. Our results suggest that the chance of newborn babies surviving with normal renal function is very low irrespective of whether or not vesicoamniotic shunting is done. UK National Institute of Health Research, Wellbeing of Women, Hannah Eliza Guy Charity (Birmingham Children's Hospital Charity). Copyright © 2013 Elsevier Ltd. All rights reserved.

Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial

PubMed Central

Morris, Rachel K; Malin, Gemma L; Quinlan-Jones, Elisabeth; Middleton, Lee J; Hemming, Karla; Burke, Danielle; Daniels, Jane P; Khan, Khalid S; Deeks, Jon; Kilby, Mark D

2013-01-01

received showed a larger effect (3·20, 1·06–9·62; p=0·03). All 12 deaths were caused by pulmonary hypoplasia in the early neonatal period. Sensitivity analysis in which non-treatment-related terminations of pregnancy were excluded made some slight changes to point estimates only. Bayesian analysis in which the trial data were combined with elicited priors from experts suggested an 86% probability that vesicoamniotic shunting increased survival at 28 days and a 25% probability that it had a large, clinically important effect (defined as a relative increase of 55% or more in the proportion of neonates who survived). There was substantial short-term and long-term morbidity in both groups, including poor renal function—only two babies (both in the shunt group) survived to 2 years with normal renal function. Seven complications occurred in six fetuses from the shunt group, including spontaneous ruptured membranes, shunt blockage, and dislodgement. These complications resulted in four pregnancy losses. Interpretation Survival seemed to be higher in the fetuses receiving vesicoamniotic shunting, but the size and direction of the effect remained uncertain, such that benefit could not be conclusively proven. Our results suggest that the chance of newborn babies surviving with normal renal function is very low irrespective of whether or not vesicoamniotic shunting is done. Funding UK National Institute of Health Research, Wellbeing of Women, Hannah Eliza Guy Charity (Birmingham Children's Hospital Charity). PMID:23953766

2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.

PubMed

2012-04-01

Third Edition [Formula: see text] [Box: see text] Printed with permission from the International Society for Biological and Environmental Repositories (ISBER) © 2011 ISBER All Rights Reserved Editor-in-Chief Lori D. Campbell, PhD Associate Editors Fay Betsou, PhD Debra Leiolani Garcia, MPA Judith G. Giri, PhD Karen E. Pitt, PhD Rebecca S. Pugh, MS Katherine C. Sexton, MBA Amy P.N. Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use. Sharing successful strategies for accomplishing this goal is one of the driving forces for the International Society for Biological and Environmental Repositories (ISBER). For more information about ISBER see www.isber.org . ISBER's Best Practices for Repositories (Best Practices) reflect the collective experience of its members and has received broad input from other repository professionals. Throughout this document

An mHealth Pain Coping Skills Training Intervention for Hematopoietic Stem Cell Transplantation Patients: Development and Pilot Randomized Controlled Trial.

PubMed

Somers, Tamara J; Kelleher, Sarah A; Dorfman, Caroline S; Shelby, Rebecca A; Fisher, Hannah M; Rowe Nichols, Krista; Sullivan, Keith M; Chao, Nelson J; Samsa, Gregory P; Abernethy, Amy P; Keefe, Francis J

2018-03-19

) were randomized to receive the mPCST intervention or to proceed with the treatment as usual. Results revealed that the mPCST participants completed an average of 5 out of 6 sessions. The participants reported that the intervention was highly acceptable (mean 3/4), and they found the sessions to be helpful (mean 8/10) and easy to understand (mean 7/7). The mPCST participants demonstrated significant improvements in pre- to post-treatment pain, self-efficacy (P=.03, d=0.61), and on the 2MWT (P=.03, d=0.66), whereas the patients in the treatment-as-usual group did not report any such improvements. Significant changes in pain disability and fatigue were found in both groups (multiple P<.02); the magnitudes of the effect sizes were larger for the mPCST group than for the control group (pain disability: d=0.79 vs 0.69; fatigue: d=0.94 vs 0.81). There were no significant changes in pain severity in either group. Using focus groups and user testing, we developed an mPCST protocol that was feasible, acceptable, and beneficial for HCT patients with pain. ClinicalTrials.gov NCT01984671; https://clinicaltrials.gov/ct2/show/NCT01984671 (Archived by WebCite at http://www.webcitation.org/6xbpx3clZ). ©Tamara J Somers, Sarah A Kelleher, Caroline S Dorfman, Rebecca A Shelby, Hannah M Fisher, Krista Rowe Nichols, Keith M Sullivan, Nelson J Chao, Gregory P Samsa, Amy P Abernethy, Francis J Keefe. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 19.03.2018.

Students Excited by Stellar Discovery

NASA Astrophysics Data System (ADS)

2011-02-01

In the constellation of Ophiuchus, above the disk of our Milky Way Galaxy, there lurks a stellar corpse spinning 30 times per second -- an exotic star known as a radio pulsar. This object was unknown until it was discovered last week by three high school students. These students are part of the Pulsar Search Collaboratory (PSC) project, run by the National Radio Astronomy Observatory (NRAO) in Green Bank, WV, and West Virginia University (WVU). The pulsar, which may be a rare kind of neutron star called a recycled pulsar, was discovered independently by Virginia students Alexander Snider and Casey Thompson, on January 20, and a day later by Kentucky student Hannah Mabry. "Every day, I told myself, 'I have to find a pulsar. I better find a pulsar before this class ends,'" said Mabry. When she actually made the discovery, she could barely contain her excitement. "I started screaming and jumping up and down." Thompson was similarly expressive. "After three years of searching, I hadn't found a single thing," he said, "but when I did, I threw my hands up in the air and said, 'Yes!'." Snider said, "It actually feels really neat to be the first person to ever see something like that. It's an uplifting feeling." As part of the PSC, the students analyze real data from NRAO's Robert C. Byrd Green Bank Telescope (GBT) to find pulsars. The students' teachers -- Debra Edwards of Sherando High School, Leah Lorton of James River High School, and Jennifer Carter of Rowan County Senior High School -- all introduced the PSC in their classes, and interested students formed teams to continue the work. Even before the discovery, Mabry simply enjoyed the search. "It just feels like you're actually doing something," she said. "It's a good feeling." Once the pulsar candidate was reported to NRAO, Project Director Rachel Rosen took a look and agreed with the young scientists. A followup observing session was scheduled on the GBT. Snider and Mabry traveled to West Virginia to assist in the

PREFACE: International Conference on Strongly Correlated Electron Systems (SCES 2011)

NASA Astrophysics Data System (ADS)

Littlewood, P. B.; Lonzarich, G. G.; Saxena, S. S.; Sutherland, M. L.; Sebastian, S. E.; Artacho, E.; Grosche, F. M.; Hadzibabic, Z.

2012-11-01

, Kyushu G. R. Stewart, Gainesville C. Di Castro, Rome R. Osborn, Chicago H. Takagi, Tokyo M. Eremets, Mainz S. Ovchnikov, Krasnoyarsk L. Taillefer, Sherbrooke M. Fiebig, Bonn C. Panagopoulos, Singapore & Heraklion J. D. Thompson, Los Alamos Z. FiskIrvine S. Paschen, Vienna Y. Tokura, Tokyo J. Flouquet, Grenoble C. Pfleiderer, Munich K. Ueda, Tokyo P. Fulde, Dresden P. Phillips, Urbana C. M. Varma, Riverside A. Geim, Manchester D. Pines, Davis T. Vojta, Rolla J.C. Gomez-Sal, Santander T. V. Ramakrishnan, Bangalore N.L. Wang, Beijing A. Kavokin, Southampton A.K. Raychaudhuri, Calcutta T. Xiang, Beijing J. Goodenough, Austin M. Reifers, Kosice L. Yu, Beijing H. Hosono, Tokyo P. Riseborough, Philadelphia F. C. Zhang, Hong Kong S. Julian, Toronto M. L Saboungi, Orleans G. Zwicknagl, Braunschweig Operational Team Anson Cheung (co-ordinator)Hyeong Jin KimPaul Nahai-Williamson Beng Tan (co-ordinator)Jack GillettPeter Logg Cheng Liu (co-ordinator)Jo WensleyPrajakti Kalra Swee K. Goh (co-ordinator)Jonathan SilverRichard Brierley Adam HalskiLara SibleyRobert Hay Edd CavannaLeona HopeSeb Haines Felix NissenLina KlintbergSitikantha Das Gareth ConduitMarianne BauerStephen Rowley Gerie LonzarichMatt BurgessSven Friedemann Greg LeverMuhammad Ahsan ZebYang Zou Hannah PriceNick BristoweYiqian Xu Haruka TaniguchiOleksandr PoplavskyyZhuo Feng

Main Parameters of Soil Quality and it's Management Under Changing Climate

NASA Astrophysics Data System (ADS)

László Phd, M., ,, Dr.

2009-04-01

Reviewing Paper Introduction: Malcolm summarised the topic of soil quality and it's management in a well synthetized form in 2000. So, the soils are fundamental to the well-being and productivity of agricultural and natural ecosystems. Soil quality is a concept being developed to characterize the usefulness and health of soils. Soil quality includes soil fertility, potential productivity, contaminant levels and their effects, resource sustainability and environmental quality. A general definition of soil quality is the degree of fitness of a soil for a specific use. The existence of multiple definitions suggests that the soil quality concept continues to evolve (Kádár, 1992; Várallyay, 1992, 1994, 2005; Németh, 1996; Malcolm, 2000; Márton, 2005; Márton et al. 2007). Recent attention has focused on the sustainability of human uses of soil, based on concerns that soil quality may be declining (Boehn and Anderson, 1997). We use sustainable to mean that a use or management of soil will sustain human well-being over time. Lal (1995) described the land resources of the world (of which soil is one component) as "finite, fragile, and nonrenewable," and reported that only about 22% (3.26 billion ha) of the total land area on the globe is suitable for cultivation and at present, only about 3% (450 million ha) has a high agricultural production capacity. Because soil is in large but finite supply, and some soil components cannot be renewed within a human time frame, the condition of soils in agriculture and the environment is an issue of global concern (Howard, 1993; FAO, 1997). Concerns include soil losses from erosion, maintaining agricultural productivity and system sustainability, protecting natural areas, and adverse effects of soil contamination on human health (Haberern, 1992; Howard, 1993; Sims et al., 1997). Parr et al. (1992) state, "...soil degradation is the single most destructive force diminishing the world's soil resource base." Soil quality guidelines are intended to protect the ability of ecosystems to function properly (Kádár, 1992; Várallyay, 1992, 1994, 2005; Cook and Hendershot, 1996; Németh, 1996; Malcolm, 2000; Márton, 2005; Márton et al. 2007). The Hungarian Ministry of Environment and Water (HMEW, 2004) suggests that the Hungarian Regions should adopt a national policy "...that seeks to conserve and enhance soil quality...". Useful evaluation of soil quality requires agreement about why soil quality is important, how it is defined, how it should be measured, and how to respond to measurements with management, restoration, or conservation practices. Because determining soil quality requires one or more value judgments and because we have much to learn about soil, these issues are not easily addressed (Várallyay, 1992, 1994, 2005; Cook and Hendershot, 1996; Németh, 1996; Malcolm, 2000). Definitions of soil quality have been based both on human uses of soil and on the functions of soil within natural and agricultural ecosystems. For purposes of this work, we are showing soil quality within the context of managed agricultural ecosystems. To many in agriculture and agricultural research, productivity is analogous to soil quality. Maintaining soil quality is also a human health concern because air, groundwater and surface water consumed by humans can be adversely affected by mismanaged and contaminated soils, and because humans may be exposed to contaminated soils in residential areas (Kádár, 1992; Várallyay, 2005; Cook and Hendershot, 1996; Németh, 1996; Malcolm, 2000; Márton et al. 2007). Contamination may include heavy metals, toxic elements, excess nutrients, volatile and nonvolatile organics, explosives, radioactive isotopes and inhalable fibers (Sheppard et al., 1992; Cook and Hendershot, 1996). Soil quality is not determined by any single conserving or degrading process or property, and soil has both dynamic and relatively static properties that also vary spatially (Carter et al., 1997). Gregorich et al. (1994) state that "soil quality is a composite measure of both a soil's ability to function and how well it functions, relative to a specific use." Increasingly, contemporary discussion of soil quality includes the environmental cost of production and the potential for reclamation of degraded soils (Várallyay, 2005). Reasons for assessing soil quality in an agricultural or managed system may be somewhat different than reasons for assessing soil quality in a natural ecosystem. In an agricultural context, soil quality may be managed, to maximize production without adverse environmental effect, while in a natural ecosystem, soil quality may be observed, as a baseline value or set of values against which future changes in the system may be compared (Várallyay, 1994; Cook and Hendershot, 1996; Németh, 1996; Malcolm, 2000; Márton et al. 2007). Soil quality has historically been equated with agricultural productivity, and thus is not a new idea. Soil conservation practices to maintain soil productivity are as old as agriculture itself, with documentation dating to the Roman Empire (Jenny, 1961). The Storie Index (Storie, 1932) and USDA Land Capability Classification (Klingebiel and Montgomery, 1973) were developed to separate soils into different quality classes. Soil quality is implied in many decisions farmers make about land purchases and management, and in the economic value rural assessors place on agricultural land for purposes of taxation. Beginning in the 1930s, soil productivity ratings were developed in the United States and elsewhere to help farmers select crops and management practices that would maximize production and minimize erosion or other adverse environmental effects (Huddleston, 1984). These rating systems are important predecessors of recent attempts to quantitatively assess soil quality. In the 1970s, attempts were made to identify and protect soils of the highest productive capacity by defining "prime agricultural lands" (Miller, 1979). An idea related to soil quality is "carrying capacity". Carrying capacity is the number of individuals that can be supported in a given area (Budd, 1992). Soils with high productivity have high carrying capacity, and are considered to be high quality. Sustainability implies that a system does not exceed its carrying capacity over time. Recent attempts to define soil quality and develop indices to measure it have many of the properties of the earlier soil productivity ratings (Doran and Jones, 1996; Snakin et al., 1996; Seybold et al., 1997). Cox (1995) calls for national goals for soil quality that "... recognize the inherent links between soil, water and air quality." Haberern (1992) suggests that the decade of the 1990s is the time to study the soil as we have recognized and studied air quality and water quality in the preceding two decades. Air and water quality standards are generally based on maximum allowable concentrations of materials hazardous to human health. They are specified and enforced by regulators according to public uses of these resources. The result is that changes in air and water quality are now monitored to protect human health. With few exceptions, soil quality standards have not been set, nor have regulations been created regarding maintenance of soil quality (Várallyay, 2005; Cook and Hendershot, 1996; Malcolm, 2000; Márton et al. 2007). To the extent that soil has been the disposal site of hazardous wastes, as well as a pathway by which contamination or other applied chemicals may present a human health risk, sporadic 40 regulations of soil quality (in terms of contamination) does exist in the 27 European Union (EU) countries for not just new ones but an estimated 30 000 existing chemicals, today. These regulations are in the form of laws regulating hazardous waste, toxic substances, and pesticides. However, these standards are often contradictory, inconsistent with each other and with current methods of assessing risk. For example, in the United States, federal regulations supporting CERCLA (40 CFR) is a list of "hazardous substances" and the levels in various media (e.g., soil, water) to which the Environmental Protection Agency (EPA) must respond with a cleanup effort. However, EPA has fielded considerable controversy about contaminant levels and chemical forms that legitimately constitute a human health risk. Target cleanup levels have also been subject to debate and legislation. Soil quality assessment requires definition of a "clean" soil (Sims et al., 1997). From this point of view, good quality soil has been defined as posing "...no harm to any normal use by humans, plants or animals; not adversely affecting natural cycles or functions; and not contaminating other components of the environment" (Moen, 1988). The parallel to air and water quality is easy to draw on a conceptual level, but designation of soil quality standards is significantly complicated by soil variability and heterogeneity (Smith et al., 1993). Among the authors (Merker, 1956; Odell et al. 1984; Johnston et al., 1986; Reganold et al., 1990; Granatstein and Bezdicek, 1992; Kádár, 1992; Beke et al., 1994; Jenkinson et al., 1994; Schjenning et al., 1994; Murata et al., 1995; Biederbeck et al., 1996; Lindert et al., 1996; Romig et al., 1995; Warkentin, 1995; Carter et al., 1997; Gerzabeck et al., 1997; Seybold et al., 1997; Malcolm, 2000; Várallyay, 2005) and organizations defining soil quality are Larson and Pierce (1991), Karlen et al. (1997). The next section reviews some of the definitions and soil characteristics used to define soil quality. The reader should understand that the definition of soil quality and selection of soil characteristics needed to quantify soil quality are continuing to evolve. For example, Bouma (1989) recognized that an essential problem with definitions that produce carefully limited suitability classes is that empirical decisions must be made to separate the classes along what is essentially a continuum. That is, if soil organic matter is part of a soil quality definition, where on the continuum of soil organic matter content does one draw the line between a high quality and low quality soil? Does high organic matter content always indicate high soil quality? These are non-trivial questions under discussion by the soil science community. Carter et al. (1997) suggest a framework for evaluating soil quality that includes: 1. describing each soil function on which quality is to be based, 2. selecting soil characteristics or properties that influence the capacity of the soil to provide each function, 3. choosing indicators of characteristics that can be measured, and 4. using methods that provide accurate measurement of those indicators. The following soil functions appear frequently in the soil science literature: 1. soil maintains biological activity/productivity (Karlen et al., 1997), serves as medium for plant/crop growth (Arshad and Coen, 1992), supports plant productivity/yield (Arshad and Coen, 1992), supports human/animal health (Karlen et al., 1997); 2. partitions and regulates water/ solute flow through environment (Larson and Pierce, 1991; Arshad and Coen, 1992); 3. serves as an environmental buffer/filter (Larson and Pierce, 1991), maintains environmental quality (Arshad and Ccen, 1992); 4. cycles nutrients, water, energy and other elements through the biosphere (Anderson and Gregorich, 1984). Clearly, these functions are interrelated. Later in this chapter, discussion focuses on the first and third functions (productivity and environmental buffering) as encompassing those aspects of soil quality most debated in the literature. Larson and Pierce (1991) defined soil quality as "the capacity of a soil to function within the ecosystem boundaries and interact positively with the environment external to that ecosystem." Three soil functions are considered essential: provide a medium for plant growth, regulate and partition waterllow through the environment, and serve as an effective environmental filter. Arshad and Coen (1992) define soil quality as "the sustaining capability of a soil to accept, store and recycle water, minerals and energy for production of crops at optimum levels while preserving a healthy environment." They discuss terrain, climate and hydrology as site factors that contribute to soil quality and suggest that socioeconomic factors such as land use, operator and management should be included in a soil quality analysis. This approach is consistent with the FAO approach to land quality analysis (FAO, 1997). Karlen et al. (1992) define soil quality as "the ability of the soil to serve as a natural medium for the growth of plants that sustain human and animal life." Their definition is based on the role of soil quality in the long-term productivity of soil and maintenance of environmental quality. Doran and Parkin (1994) defined soil quality as "the capacity of a soil to function within ecosystem boundaries to sustain biological productivity, maintain environmental quality, and promote plant and animal health." Gregorich et al. (1994) define soil quality as "a composite measure of both a soil's ability to function and how well it functions relative to a specific use" or "the degree of fitness of a soil for a specific use." The Soil Science Society of America Ad Hoc Committee on Soil Health proposed that soil quality is "the capacity of a specific kind of soil to function, within natural or managed ecosystem boundaries, to sustain plant and animal productivity, maintain or enhance water and air quality, and support human health and habitation" (Karlen et al., 1997). This definition requires that five functions must be evaluated to describe soil quality: 1. sustaining biological activity, diversity, and productivity; 2. regulating and partitioning water and solute flow; 3. filtering, buffering, degrading, immobilizing and detoxifying organic and inorganic materials, including industrial and municipal byproducts and atmospheric deposition; 4. storing and cycling nutrients and other elements within the earth's biosphere; and 5. providing support of socioeconomic structures and protection for archeological treasures associated with human habitation. No soil is likely to successfully provide all of these functions, some of which occur in natural ecosystems and some of which are the result of human modification. We can summarize by saying that soil quality depends on the extent to which soil functions to benefit humans. Thus, for food production or mediation of contamination, soil quality means the extent to which a soil fulfills the role we have defined for it. Within agriculture, high quality equates to maintenance of high productivity without significant soil or environmental degradation. The Glossary of Soil Science terms produced by the Soil Science Society of America (1996) states that soil quality is an inherent attribute of a soil that is inferred from soil characteristics or indirect observations. To proceed from a dictionary definition to a measure of soil quality, a minimum dataset (MDS) of soil characteristics that represents soil quality must be selected and quantified (Papendick et al., 1995). The MDS may include biological, chemical or physical soil characteristics [Organic matter (OM), Aggregation (A), Bulk density (BD), Depth to hardpan (DH), Electrical conductivity (EC), Fertility (F), Respiration (R), pH, Soil test (ST), Yield (Y), Infiltration (I), Mineralizable nitrogen potential (MNP), Water holding capacity (WHC)]. For agriculture, the measurement of properties should lead to a relatively simple and accurate way to rank soils based on potential plant production without soil degradation. Unfortunately, commonly identified soil quality parameters may not correlate well with yield (Reganold, 1988). In the next section, we consider these four points concerning the selection and quantification of soil characteristics: 1. soil characteristics may be desirable or undesirable, 2. soil renewability involves judgment of the extent to which soil characteristics can be controlled or managed, 3. rates of change in soil characteristics vary, and 4. there may be significant temporal or spatial variation in soil characteristics. Components of soil quality definitions may include desirable and undesirable characteristics. Desirable soil characteristics may either be the presence of a property that benefits soil productivity and/or other important soil functions, or the absence of a property that is detrimental to these functions. A soil characteristic may include a range of values that contributes positively to quality and a range that contributes negatively. Soil pH, for example, may be a positive or negative characteristic depending on its value. Larson and Pierce (1991) suggest that ranges of property values can be defined as optimal, suboptimal or superoptimal. A pH range of 6 to 7.5 is optimal for production of most crops. Outside of this range, pH is suboptimal and soil quality is lower than at the optimal pH range. The complexity of the soil quality concept is illustrated by the fact that the choice of optimal pH range is crop or use dependent. Letey (1985) suggested that identification of a range of water content that is nonlimiting to plant productivity might be a good way of assessing the collective effect of soil physical characteristics that contribute to crop productivity. For soils of decreasing quality, the width of the nonlimiting water range decreases. Undesirable soil characteristics may be either the presence of contaminants or a range of values of soil characteristics that contribute negatively to soil quality. The presence of chemicals that inhibit plant root growth or the absence of nutrients that result in low yields or poor crop quality are examples of undesirable soil characteristics that lower soil quality. The extent to which soil is viewed as a renewable resource shapes our approach to soil quality. "Soil" in this context is the natural, three-dimensional, horizonated individual, not something created by earth moving machinery. For the purpose of assessing human impact on sustainability of soil quality, it may be appropriate to use only those soil properties that are slowly or nonrenewable. Shorter term assessments may be based on those properties that change rapidly and are subject to easy management. Willis and Evans (1977) argued that soil is not renewable over the short term based on studies that suggest that 30 to more than 1,000 years are required to develop 25 mm of surface soil from parent material by natural processes. Jenny (1980) also argued that soil is not renewable over the time scale to which humans relate. Howard (1993) suggests defining soil quality based on undisturbed natural soils and to set quality standards based on changes in soils which cannot be reversed naturally or by ecological approaches. The renewability of soil depends on the soil property considered. For example, once soil depth is reduced by wind or water erosion so that it is too shallow to support crops, it is not renewable within a human or management time frame. Some important soil characteristics are slowly renewable. Organic matter, most nutrients and some physical properties may be renewed through careful long-term management. Certain chemical properties (pH, salinity, N, P, K content) may be altered to a more satisfactory range for agriculture within a growing season or two, while removal of unwanted chemicals may take much longer. No soil property is permanent, but rates and frequency of change vary widely among properties. Soil properties also vary with ecosystem, arguably depending most on climate. In rangelands, for example, temporal variability is high and relatively unpredictable due to the strong dependence of soil properties on soil wetness (Herrick and Whitford, 1995). Variability in soil wetness is not restricted to rangelands and may be an especially important determinant of microbial community structure and function in both irrigated and rainfed agricultural systems. Arnold et al. (1990) suggest that changes in soil properties can be nonsystematic, periodic, or trend. Nonsystematic changes are short term and unpredictable. Periodic are predictable and trend changes tend to be in one direction over time. Carter et al. (1997) distinguish between dynamic soil properties that are most subject to change through human use and are strongly influenced by agronomic practices, and intrinsic or static properties that are not subject to rapid change or management. Examples of dynamic soil characteristics are the size, membership, distribution, and activity of a soil's microbiological community; the soil solution composition, pH, and nutrient ion concentrations, and the exchangeable cation population. Soils respond quickly to changes in conditions such as water content. As a result, the optimal frequency and distribution of soil measurements vary with the property being measured. Soil mineralogy, particle size distribution and soil depth are static soil quality indicators. Although changes occur continuously, they are slow under natural conditions. Organic matter content may be a dynamic variable, but the chemical properties of organic matter may change only over periods on the order of 100 to 1,500 years depending on texture. Soil properties that change quickly present a problem because many measurements are needed to know the average value and to determine if changes in the average indicate improvement or degradation of soil quality. Conversely, properties that change very slowly are insensitive measures of short-term changes in soil quality. Papendick et al. (1995) argue that the MDS required for soil quality analysis includes a mix of "dynamic" and relatively "static" properties. A soil quality assessment must specify area. One could use the pedon (the three-dimensional soil individual) as the unit of measure, or a soil map unit, a landscape, a field or an entire watershed. The choice will depend to some degree on what property is of interest and the spatial variability of the property. Karlen et al. (1997) propose that soil quality can be evaluated at scales ranging from points to regional, national and international. They suggest that the more detailed scales provide an opportunity to "understand" soil quality while larger scale approaches provide interdisciplinary monitoring of soil quality and changes in soil quality. Pennock et al. (1994) discuss scaling up data from discrete sampling points to landscape and regional scales. Soil physical characteristics [Aeration (A), Aggregate stability (AS), Bulk density (BD), Clay mineralogy (CM), Color (C), Consistence (dry (CD), moist (CM), wet (CW)), Depth to root limiting layer (DRLL), Hydraulic conductivity (HC), Oxygen diffusion rate (ODR), Particle size distribution (PSD), Penetration resistence (PR), Pore connectivity (PC), Pore size distribution (PSD), Soil strength (SS), Soil tilth (ST), Structure type (STY), Temperature (T), Total porosity (TP), Water-holding capacity (WHC)] are a necessary part of soil quality assessment because they often cannot be easily improved (Wagenet and Hutson, 1997). Larson and Pierce (1991) summarize the physical indicators of soil quality as those properties that influence crop production by determining: 1. whether a soil can accommodate unobstructed root growth and provide pore space of sufficient size and continuity for root penetration and expansion, 2. the extent to which the soil matrix will resist deformation, and 3. the capacity of soil for water supply and aeration. Factors such as effective rooting depth, porosity or pore size distribution, bulk density, hydraulic conductivity, soil strength and particle size distribution capture these soil functions (Malcolm, 2000; Várallyay, 2005). Reganold and Palmer (1995) use texture, color, dry and moist consistence, structure type, a structure index, bulk density of the 0-5 cm zone, penetration resistance of 0 to 20 and 20 to 40 cm zones and topsoil thickness as physical determinants of soil quality. Letey (1994) suggests that structure, texture, bulk density, and profile characteristics affect management practices in agriculture but are not directly related to plant productivity. He proposes that water potential, oxygen diffusion rate, temperature, and mechanical resistance directly affect plant growth, and thus are the best indicators of the physical quality of a soil for production. Soil tilth, a poorly defined term that describes the physical condition of soil, also may be an indicator of a soil's ability to support crops. Farmers may assess soil tilth by kicking a soil clod. More formal measurements to describe soil ti]th include bulk density, porosity, structure, roughness and aggregate characteristics (Karlen et al., 1992). Many of the processes that contribute to soil structure, aggregate stability, bulk density and porosity are not well understood, making soil tilth a difficult parameter to quantify. Soil depth is an easily measured and independent property that provides direct information about a soil's ability to support plants. Effective soil depth is the depth available for roots to explore for water and nutrients. Layers that restrict root growth or water movement include hard rock, naturally dense soil layers such as fragipans, petrocalcic and, petroferric horizons, duripans, and human-induced layers of high bulk density such as plow pans and traffic pans. Effective soil depth is a problem for agricultural use of over 50% of soils in Africa (Eswaran et al., 1997). Soil depth requirements vary with crop or species. Many vegetable crops, for example, are notably shallow rooted while grain crops and some legumes like alfalfa are deep rooted. Variation will be even greater in unmanaged, natural systems. Wheat yield in Colorado was shown to decrease from 2,700 to 1,150 kg ha' over a 60-yr period of cultivation primarily due to decrease in soil depth (Bowman et al., 1990). Assessment of soil quality based on soil chemistry, whether the property is a contaminant or part of a healthy system, requires a sampling protocol, a method of chemical analysis, an understanding of how its chemistry affects biological systems and interacts with mineral forms, methods for location of possible contamination, and standards for soil characterization (Várallyay, 2005; Németh, 1996; Malcolm, 2000). Some soil chemical properties suggested as soil quality indicators are: Base saturation percentage (BSP), Cation exchange capacity (CEC), Contaminant availability (CA), Contaminant concentration (CC), Contaminant mobility (CM), Contaminant presence (CP), Electrical conductivity (EC), ESP, Nutrient cycling rates (NCR), Ph, Plant nutrient availability (PNA), Plant nutrient content (PNC) and SAR. Nutrient availability depends on soil physical and chemical processes, such as weathering and buffering, and properties such as organic matter content, CEC and pH (Kádár, 1992; Várallyay, 1992, 1994, 2005; Németh, 1996; Malcolm, 2000; Márton, 2005; Márton et al. 2007). At low and high pH, for example, some nutrients become unavailable to plants and some toxic elements become more available. Larson and Pierce (1991) chose those chemical properties that either inhibit root growth or that affect nutrient supply due to the quantity present or the availability. Reganold and Palmer (1995) used chemical parameters related to nutrient availability as measures of soil quality, including CEC, total N and P, pH and extractable P, S, Ca, Mg and K. Karlen et al. (1992) suggest that total and available plant nutrients, and nutrient cycling rates, should be included in soil quality assessments. Soil properties may be severely compromised by intended or unintended human additions of chemical compounds and soil productivity reduced if unwanted chemicals exceed safe thresholds. Data are required to determine whether or not a site is significantly polluted and if it requires clean-up (Sims et al., 1997). International standard methods have been created to maintain the quality of measurements (Hortensius and Welling, 1996). A difficult determination is the level of each chemical that is considered an ecological risk. Beck et al. (1995) provide a list of levels for organic chemicals adopted by The Netherlands and Canada. EPA uses similar lists for compounds considered hazardous (e.g., 40 CFR). Sims et al. (1997) argue that clean and unclean are two extremes of a continuum and that it is more appropriate to define the physical, chemical and biological state of the soil as acceptable or unacceptable. In The Netherlands, soil quality reference values have been created for heavy metals and organic chemicals based on a linear relationship with soil clay and organic matter content. The Dutch Ministry of Housing, Physical Planning and Environment has used the maximum of a range of reference values for a given substance as a provisional reference value for good soil quality (Howard, 1993). The focus of many soil quality definitions is soil biology [Organic carbon (OC), Microbial biomass (MB), C and N, Total bacterial biomass (TBB), Total fungal biomass (TFB), Potentially mineralizable N (PMN), Soil respiration (SR), Enzymes (Dehydrogenase, Phosphatase, Arlysulfatase), Biomass C/total organic carbon, Respiration/biomass, Microbial community fingerprinting (MCF), Substrate utilization (SU), Fatty acid analysis (FAA), Nucleic acid analysis (NAA)]. Soil supports a diverse population of organisms, ranging in size from viruses to large mammals, that usually interacts positively with plants and other system components (Paul and Clark, 1996). However, some soil organisms such as nematodes, bacterial and fungal pathogens reduce plant productivity. Many proposed soil quality definitions focus on the presence of beneficial rather than absence of detrimental organisms, although both are critically important. Various measures of microbial community viability have been suggested as measures or indices of soil quality. Community level studies consider species diversity and frequency of occurrence of species. Visser and Parkinson (1992) found that diverse soil microbiological criteria may be used to indicate deteriorating or improving soil quality. They suggested testing the biological criteria for soil quality at three levels: population, community and ecosystem. Microorganisms and microbial communities are dynamic and diverse, making them sensitive to changes in soil conditions (Kennedy and Papendick, 1995). Their populations include fungi, bacteria including actinomycetes, protozoa, and algae. Soil microorganisms form crucial symbiotic relationships with plants, including mycorrhizal infection for P and N acquisition and bacterial infection for fixation of atmospheric N. Authors emphasizing use of biological factors as indicators of soil quality often equate soil quality with relatively dynamic properties such as microbial biomass, microbial respiration, organic matter mineralization and denitrification, and organic matter content (Yakovchenko et al., 1996; Franzluebbers and Arshad, 1997), or soil microbial C, phospholipid analyses and soil enzymes (Gregorich et al., 1997), or total organic C and N (Franco-Vizcaino, 1997). Visser and Parkinson (1992) question the suitability of enzyme assays for microbial activity and soil quality assessments. Waksman (1927), who studied measurements of soil microorganisms that could indicate soil fertility, found that physical and chemical factors as well as soil biology were needed to predict soil fertility. Meso- and macrofauna populations have also been considered as part of soil quality definitions (Berry, 1994). One could choose to use presence or absence of a particular species or population of a particular species as a measure of soil quality. Stork and Eggleton (1992) discuss species richness as a powerful indicator of invertebrate community and soil quality, although determining the number of species is a problem. They suggest that keystone species, taxonomic diversity at the group level, and species richness of several dominant groups of invertebrates can be used as part of a soil quality definition. Measuring soil fauna populations involves decisions about which organisms to measure and how to measure them. An example is the earthworm population, the size of which is frequently mentioned as an important measure of soil quality. Measurement choices include numbers of organisms per volume or weight of soil, number of species, or a combination of numbers of organisms and species. Reganold and Palmer (1995) use total earthworms per square meter, total earthworm weight (g m-') and average individual earthworm weight as biological indicators of soil quality. Measurement of one or more components of the N cycle including ammonification, nitrification and nitrogen fixation, may be used to assess soil fertility and soil quality (Visser and Parkinson, 1992). Presumably, high rates of N turnover may infer a dynamic and healthy soil biological community. In contrast, low soil quality or poor soil health may be inferred from lack of N turnover. The interpretation of N turnover rates is highly dependent on the kinds of substrates added to soils and climate variables such as soil temperature and moisture. One needs to be careful when comparing N turnover rates within soils and among different soils to be sure that the cause of differences is a soil quality parameter and not natural variability. Presence of pesticide residues, for example, may reduce N turnover rate. In such an instance, both the presence of the pesticide and the N turnover rate would be needed to determine that the soil quality had been impaired. Production incorporates use of and need for functioning soil resources in agriculture, and environmental buffering incorporates the direct and indirect effects of human use on ecosystem function and human health (Kádár, 1992; Várallyay, 1992, 1994, 2005; Németh, 1996; Malcolm, 2000; Márton, 2005; Márton et al. 2007). Worldwide agriculture is the most extensive human land use, and soil characteristics are a critical determinant of agricultural productivity. Agriculture includes irrigated and rainfed cultivated cropland, permanent crops such as orchards and vineyards, irrigated pasture, range, and forestry. Each cropping system has distinct soil and soil management conditions for optimal production. It has been suggested that soil productivity is the net resultant of soil degradation processes and soil conservation practices (Parr et al., 1990). An appropriate definition of soil quality and the criteria necessary to evaluate and monitor soil quality is a step toward "the development of systematic criteria of sustainability". Issues to be considered when discussing soil quality for agriculture include: 1. How are productivity and sustainability related? 2. Is the cropping system in question cultivated or non-cultivated? 3. Is the cropping system in question an irrigated or dryland system? Sustainability of agricultural systems is critical to human welfare and is an a subject of research and debate (Letey, 1994). High productivity and sustainability must be converging goals if the growing human population is to be fed without destroying the resources necessary to produce food. Sustainability implies that a system is at a desirable steady state. Thermodynamically, soil is an open system through which matter and energy flow and a steady state is characterized by a minimum production of entropy (Andiscott, 1995). Ellert et al. (1997) review related literature on ways of assessing soil function on an ecosystem scale, commenting that the complexity and organization of living systems, which seem to defy the second law of thermodynamics (increasing disorder/entropy), may provide a means to broadly assess ecosystem function. The purpose of agriculture is to provide products for human sustenance and by definition is not sustainable unless the nutrients removed in the products are returned to the soil. Many of the arguments about the sustainability of agricultural systems relate to the form in which nutrients are most sustainably returned. No agricultural system will be sustainable in the long run without management that considers nutrient cycling and energy budgets. The more intense the agricultural system, the more energy and resources must be expended to maintain the system. The relative quality of a soil for agriculture can depend on the resources available to farmers. In the United States, resources may be readily available for management of dynamic soil properties such as nutrient or water status. In other countries, farmers may be resource poor, and agricultural systems are generally low input, meaning that large-scale irrigation is absent, use of fertilizers, pesticides, and herbicides is minimal, and high energy, mechanized equipment is not available (Eswaran et a1.,1997). This means, for example, that soil quality for agriculture will be more dependent on climate than if the same soils were part of a highly managed, irrigated system. Similarly, sustainability is more dependent on maintenance of dynamic soil properties because resources may not exist to remedy losses (Várallyay, 2005; Malcolm, 2000; Márton et al. 2007). It is difficult to overstate the importance of irrigation to food production. One-third of the total global harvest of food comes from the 17% (250 million ha) of the world's cropland that is irrigated (Hoffman et al., 1990); three-quarters of which are in developing countries (Tribe, 1994). India, China, the former Soviet Union, the United States and Pakistan have the greatest area of irrigated land. Should soil quality criteria be the same for irrigated and dryland agriculture? Sojka (1996) suggests that the arid and semi-arid soils that support most irrigated agriculture have thin erodible surfaces, characteristics that would classify such soils as having poor quality. Yet under irrigation, they feed much of the world. Without irrigation, for example, in many African soils, moisture stress becomes a significant factor limiting production, and the water-holding capacity of a soil becomes crucial (Eswaran et al., 1997). This suggests that a standard set of criteria based on potential productivity is not a sufficient definition of soil quality. Soils that are not cultivated are a much larger component of agriculture, broadly defined, than those that are cultivated. About 65% of the land in the United States is forest (284 million ha) or range land (312 million ha), with only about 284 million hacultivated (NRC,1994). Herrick and Whitford (1995) suggest that range land soils, which often serve multiple uses, present unique challenges and opportunities for assessing soil quality because spatial and temporal variability are higher than in cropped systems. On range lands and forest lands, food, fiber, timber production, biomass for fuel, wildlife, biodiversity, recreation, and water supply are all potential uses that may have diverse criteria for quality soils. Herrick and Whitford (1995) give the example of a thick O horizon that may be an indicator of good timber production but has no predictive value of soil quality for the rancher. The National Research Council (NRC, 1994) recommends that range land health be determined using three criteria: degree of soil stability and watershed function, integrity of nutrient cycles and energy flows, and presence of functioning recovery mechanisms. Soil erosion by wind and water and infiltration or capture of precipitation were selected as processes that could be used as indicators of soil stability and watershed function. Specific indicators or properties need to be related to these two broad processes. The amount of nutrients available, the speed with which nutrients cycle, and measures of the integrity of energy flow through the system were considered fundamental components of range land health. Finally, the capacity of range land ecosystems to react to change depends on recovery mechanisms that result in capture and cycling of nutrients, capture of energy, conservation of nutrients, energy and water, and resilience to change. Specific indicators include status of vegetation, age class and distribution (Kádár, 1992; Várallyay, 1992, 1994, 2005; Németh, 1996; Malcolm, 2000; Márton et al. 2007). The evaluation of land quality for forestry is a well-known practice. Indices range from quantitative through semi-quantitative to qualitative. Quantitative evaluations, such as site index, use regression equations to predict tree height at a predetermined tree age based on soil and climate data. Qualitative evaluations assign land to classes based on soil and climate properties. In soil science, the term "buffer" refers collectively to processes that constrain shifts in the dissolved concentration of any ion when it is added to or removed from the soil system (Singer and Munns, 1996). Soils "buffer" nutrients as well as contaminants and other solutes, via sorption to or incorporation into clay and organic materials. The extent to which a soil immobilizes or chemically alters substances that are toxic, thus effectively detoxifying them, reflects "quality" in the sense that humans or other biological components of the system are protected from harm. This is the basis for the European concept of soil quality (Moen, 1988; Siegrist, 1989; Denneman and Robberse, 1990). Lack of soil function in this category is reflected as direct toxicity or as contamination of air or water. Identifying substances that qualify as "contaminants" can be challenging because some, such as nitrates and phosphates, are important plant nutrients as well as potential water pollutants. An example is agricultural runoff containing N03 or soluble P (Yli-Halla et al., 1995). This chapter does not attempt a comprehensive review of research in this area, which is covered in an earlier chapter, but instead presents a few sample articles pertinent to this aspect of soil quality. Holden and Firestone (1997) define soil quality in this context as "the degree to which the physical, chemical, and biological characteristics of the soil serve to attenuate environmental pollution." Howard (1993) defines the ecological risk of a chemical in the environment as "the probability that a random species in a large community is exposed to a concentration of the chemical greater than its no-effect level." The extent to which a soil is capable of reducing the probability of exposure is a measure of its quality. A well-studied example of a common soil contaminant is Pb (McBride et al., 1997). Although legislated limits may be on a concentration basis in soil (e.g., 500 ftg kg-'), risk assessment techniques have attempted to account for the chemical form of Pb present, as well as the observed relative relationship between the amount of Pb present in soil and blood levels in local residents (Bowers and Gauthier, 1994). Critics have questioned analytical techniques used to determine bioavailable levels of Pb in soil, as well as the degree to which toxicity data account for its chemical fate and ecologically damaging properties (Cook and Hendershot, 1996). Natural variability of soils and variation within a soil series make average values or average background values inadequate for soil quality assessments. In addition, bioaccumulation and toxicity need to be considered when establishing levels of toxicants that may not be exceeded in a "high quality" soil for a given use (Traas et al. 1996). Another example is the effect of heavy metals such as Cr(VI) on soil biological properties. Based on a study of three New Zealand soils of contrasting texture, organic matter content, and CEC, Speir et al. (1995) propose an "ecological dose value" that represents the inhibitory effects of a heavy metal (in this case, Cr(VI)) on the kinetics of soil biological properties, and serves as a generic index for determination of permissible concentration levels for heavy metals in soils. A single soil characteristic is of limited use in evaluating differences in soil quality (Reganold and Palmer, 1995). Using more than one quantitative variable requires some system for combining the measurements into a useful index (Halvorson et al., 1996). The region, crop, or general soil use for which an index was created will likely limit its effectiveness outside the scope of its intended application. Even an index designed only to rate productivity is not likely to be useful for all crops and soils, leading Gersmehl and Brown (1990) to advocate regionally targeted systems. Rice is a good example of a crop requiring significantly different soil properties than other crops. It is a food staple for a large proportion of the world population. Approximately 146 million ha were in rice production in 1989 (FAO, 1989) mainly (90%) in Asia. High quality soils for paddy rice may be poor quality for most other irrigated and dryland crops because they may be saline or sodic, and high in clay with slow infiltration and permeability. These physical and chemical properties often constrain production of other crops. Although they are not reviewed here, various land suitability classifications specifically for rice have been developed since the turn of the century (Dent, 1978). Examples of several soil quality indexing systems are presented in the following sections. To some extent, recent attempts to enumerate the factors of soil quality resemble Jenny's (1941) introduction of the interrelated factors of soil formation. An index is categorized here as nonquantitative if it does not combine evaluated parameters into a numerical index that rates soils along a continuous scale. Examples are the USDA Land Capability Classification and the US Bureau of Reclamation (USBR) Irrigation Suitability. The purpose of the Land Capability Classification (LCC) was to place arable soils into groups based on their ability to sustain common cultivated crops that do not require specialized site conditioning or treatment (Klingebiel and Montgomery, 1973). Nonarable soils, unsuitable for long-term, sustained cultivation, are grouped according to their ability to support permanent vegetation, and according to the risk of soil damage if mismanaged. The LCC combines three rating values at different levels of abstraction: capability class, subclass, and unit. At the most general level, soils are placed in eight classes according to whether they (a) are capable of producing adapted plants under good management (classes I to N), (b) are capable of producing specialized crops under highly intensive management involving "elaborate practices for soil and water conservation" (classes V to VII), or (c) do not return on-site benefits as a result of management inputs for crops, grasses or trees without major reclamation (Klingebiel and Montgomery, 1973). The four possible limitations/hazards under the subclass rating are erosion hazard, wetness, rooting zone limitations and climate. The capability unit groups soils that have about the same responses to systems of management and have longtime estimated yields that do not vary by more than 25% under comparable management. The issue of critical limits is a difficult one in soils because of the range of potential uses and the interactions among variables (Arshad and Ccen, 1992). Several studies have shown that lands of higher LCC have higher productivity than lands of lower LCC (Patterson and Mackintosh, 1976; van Vliet et al., 1979; Reganold and Singer, 1984). In a study of 744 alfalfa, corn, cotton, sugar beet and wheat growing fields in the San Joaquin Valley of California, those with LCC ratings between 1 and 3 had significantly lower input/output ratios than fields with ratings between 3.01 and 6 (Reganold and Singer, 1984). This suggests that use of the LCC system provides an economically meaningful assessment of soil quality for agriculture. This was a frequently used system of land evaluation for irrigation in the Western US during the period of rapid expansion of water delivery systems (McRae and Burnham, 1981). It combines social and economic evaluations of the land with soil and other ecological variables to determine if the land has the productive capacity, once irrigated, to repay the investment necessary to bring water to an area. It recognizes the unique importance of irrigation to agriculture and the special qualities of soils that make them irrigable. Quantitative systems result in a numerical index, typically with the highest number being assigned to the best quality soils. Systems may be additive, multiplicative or more complex functions. They have two important advantages over nonquantitative systems: 1. they are easier to use with GIS and other automated data retrieval and display systems, and 2. they typically provide a continuous scale of assessment. No single national system is presently in use but several state or regional systems exist. Although he considered the productivity of the land to be dependent on 32 soil, climate and vegetative properties [Surface conditions: Physiographic position, Slope, Microrelief, Erosion deposition, External drainage, runoff. Soil physical conditions: Soil color, Soil depth, Soil density and porosity, Soil permeability, Soil texture, Stoniness, Soil structure, Soil workability-consistence, Internal drainage, Water-holding capacity, Plant-available water. Soil chemical conditions: Organic matter, Nitrogen, Reaction, Calcium carbonate, bases, Exchange capacity, Salts: Cl, SO Na, Toxicities, e.g., B, Available P, Available K, Minor elements, e.g., Zn, Fe, Fertility. Mineralogical conditions: Mineralogy. Climate: Precipitation Temperature Growing season Winds. Vegetativé cover: Natural vegetation], only nine properties were used in the SIR, because incorporating a greater number of factors made the system unwieldy. The nine factors are soil morphology (A), surface texture (B), slope (C), and six variables (X.) that rate drainage class, sodicity, acidity, erosion, microrelief and fertility; rated from 1% to 100%. These are converted to their decimal value and multiplied together (Storie, 1964). Values for each factor were derived from Storie's experience mapping and evaluating soils in California, and in soil productivity studies in cooperation with the California Agricultural Experiment Station cost-efficiency projects relating to orchard crops, grapes and cotton. In describing the SIR (SIR= [AxBxCxIIXi]x100), Storie (1932, 1964) explicitly mentioned "soil quality". Soils that were deep, had no restricting subsoil horizons, and held water well had the greatest potential for the widest range of crops. The usefulness of the SIR as a soil quality index would be greatest if there was a statistically significant relationship between SIR values and an economic indicator of land value. Reganold and Singer (1984) found that area-weighted average SIR values between 60 and 100 for 744 fields in the San Joaquin Valley of California had lower but statistically insignificant input/output ratios than fields with indices < 60. The lack of statistical significance does not mean that better quality lands could not be farmed at economically lower cost or at higher cost and higher output than the lower quality lands. We productivity index model (PI) was developed to evaluate soil productivity in the top 100 cm, especially with reference to potential productivity loss due to soil erosion (Neill, 1979; Kiniry et al., 1983). The PI model rates soils on the sufficiency for root growth based on potential available water storage capacity, bulk density, aeration, pH, and electrical conductivity. A value from zero to one is assigned to each property describing the importance of that parameter for root development. The product of these five index values is used to describe the fractional sufficiency of any soil layer for root development. Pierce et al. (1983) modified the PI to include the assumption that nutrients were not limiting and that climate, management and plant differences are constant. A number of authors found that it is useful to various degrees (Gantzer and McCarty, 1987; Lindstrom et al., 1992). Parr et al. (1992) suggest that a SQI could take the form of Equation: SQI = f (SP, P, E, H, ER, BD, FQ, MI) where SQI is a function of soil properties (SP), potential productivity (P), environmental factors (E), human and animal health (H), erodibility (ER), biological diversity (BD), food quality and safety (FQ) and management inputs (MI). Determination of the specific measurable indicators of each variable and the interactions among these diverse variables is a daunting task. Moreover, the mathematical method of combining these factors, as well as the resulting value that would indicate a high quality soil, is not specified. The inclusion of variables BD, FQ and MI make this a land quality index as suggested by FAO (1997). Larson and Pierce (1991) defined soil quality (Q) as the state of existence of soil relative to a standard or in terms of a degree of excellence. They argue that defining Q in terms of productivity is too limiting and does not serve us well. Rather, Q is defined as the sum of individual soil qualities q. and expressed as Equation: Q=f(qi ...qn). These authors do not identify the best subset of properties or their functional and quantitative relationship, but do suggest that a MDS should be selected from those soil characteristics in which changes are measurable and relatively rapid (i.e., "dynamic" properties), arguing that it is more important to know about changes in soil quality (dQ) than the magnitude of Q (Larson and Pierce, 1991). Changes in soil quality are a function of changes in soil characteristics (q) over time (t): dQ = f[(qi.t - qit0 )... (qn.t-qnt0)]. If dQ/dt is ≥0, the soil or ecosystem is improving relative to the standard at time to. If dQ/dt <0, soil degradation is occurring. Time zero can be selected to meet management needs or goals. If there is a drastic change in management, time zero can be defined as prior to the change. If a longer time period of comparison is considered more appropriate, properties of an uncultivated or pristine soil could be used. The MDS recommended by Larson and Pierce (1991) includes N mineralization potential or P buffering capacity, total organic C, labile organic C, texture, plant-available water capacity, structure (bulk density is recommended as a surrogate variable), strength, maximum rooting depth, pH and EC. In instances when data are unavailable, pedotransfer functions (Bouma, 1989) can be used to estimate values of soil characteristics. These estimates can then be used as part of the minimum dataset to estimate soil quality or changes in soil quality brought about by management. Although this is a quantitative system, some qualitative judgments are needed to make decisions about changes in soil quality. In particular, interpretation of the meaning of magnitude of changes in a characteristic or the number of characteristics to change from time zero to the time of the measurement is qualitative. The authors do not address how large a change in pH, soil depth, bulk density or organic C represents serious soil degradation, or the values that define soil as high or low quality. Karlen et al. (1994) developed QI based on a 10-year crop residue management study. QI is based on four soil functions: (1) accommodating water entry, (2) retaining and supplying water to plants, (3) resisting degradation, and (4) supporting plant growth. Numerous properties were measured and values normalized based on standard scoring functions. One function is based on the concept that more of a property is better, one that less is better and the third that an optimum is better. Lower threshold values receive a score of zero, upper threshold values receive a score of one, and baseline values receive a score of one-half. Priorities are then assigned to each value. For example, aggregate stability was given the highest weight among factors important in water entry. After normalizing, each value is then multiplied by its weighting factor (wt) and products are summed Equation: QI=qwe (wt) + qwt (wt)+qrd (wt) + qspg (wt). Subscripts refer to the four main functions described earlier. It should also be noted that resisting degradation (rd) and sustaining plant growth (spg) are assigned secondary and tertiary levels of properties that themselves are normalized and weighted before a final value is calculated and incorporated into Equation. The resulting index resulted in values between zero and one. Of the three systems in the study, the one with the highest rate of organic matter return to the soil had the highest index value, and the soil with the lowest had the lowest value. The authors suggest that this demonstrates the usefulness of the index for monitoring the status and change in status of a soil as a function of management. They also suggest that the index and the soil characteristics that go into the index may change as the index is refined (Karlen et al. 1994). Snakin et al. (1996) developed an index of soil degradation that assigns three separate values from one to five reflecting the degree to which a soil's physical, chemical, and biological properties are degraded, as well as the rate of degradation. The Canadian soil capability classification system is similar to the older US systems and is quantitative. In a study in southwestern Ontario, Patterson and Mackintosh (1976) found that high gross returns per ha were three times as likely if the productivity index of land, based on the soil capability classification, was between 90 and 100 than if it fell between 80 and 89. Smith et al. (1993) and Halvorson et al. (1996) propose a multiple-variable indicator transform procedure to combine values or ranges of values that represent the best estimate of soil quality. Their system converts measured data values into a single value according to specified criteria. They do not attempt to define soil quality or specify what soil characteristics are to be used. They combine this procedure with kriging to develop maps that indicate the probabilities of meeting a soil quality criterion on a landscape level. Critical threshold values must be known, assumed, or determined in order to separate different soil qualities. Numerous additive productivity rating systems have been developed for specific states, as reviewed by Huddleston (1984). In these systems, soil properties are assigned numerical values according to their expected impact on plant growth. The index is usually calculated as the sum of the values assigned to each property with 100 the maximum value. Huddleston (1984) notes advantages and disadvantages to such a system which are similar to those for many of the soil quality indices previously discussed. Additive systems become complex as the number of factors, cropping systems, and soil and climatic conditions increases. A unique problem of subtractive systems (one in which 100 is the starting point and values are deducted for problem conditions) is that negative values result when multiple factors are less than satisfactory. Soil quality is a concept being developed to characterize the usefulness and health of soils, because soils are fundamental to the well-being and productivity of agricultural and natural ecosystems. It is a compound characteristic that cannot be directly measured. Many definitions of soil quality can be found in the literature and no set of soil characteristics has been universally adopted to quantify definitions. Soil quality is often equated with agricultural productivity and sustainability. An approach toward developing soil quality definitions is one that assesses soil quality in the context of a soil's potential to perform given functions in a system; e.g., maintains productivity, partitions and regulates water and solute flow through an ecosystem, serves as an environmental buffer, and cycles nutrients, water, and energy through the biosphere. Air and water quality standards are usually based on maximum allowable concentrations of materials hazardous to human health. A definition of soil quality based on this concept would encompass only a fraction of the important roles soils play in agriculture and the environment but could be essential to soil remediation. To proceed from a definition to a measure of soil quality, a minimum dataset of soil characteristics that represent soil quality must be selected and quantified. Many soil physical, chemical and biological properties have been suggested to separate soils of different quality. These include desirable and undesirable properties. Desirable soil characteristics may either be the presence of a property that benefits crop productivity and environmental buffering and/or other important soil functions, or the absence of a property that is detrimental to these functions. In particular, absence of contaminants is an important soil quality characteristic. In selecting characteristics, it is necessary to recognize that some soil properties are static, in the sense that they change slowly over time and others are dynamic. In addition, spatial and temporal variability of soil properties must be considered when selecting the properties used to assess soil quality. A single soil property is of limited use in evaluating soil quality. Qualitative and quantitative soil quality indices have been suggested that combine quantitative values of soil properties. Quantitative systems may be additive, multiplicative or more complex functions. Regardless of the definition or suite of soil variables chosen to define and quantify soil quality, it is critical to human welfare that soils be managed to provide for human health and well-being while minimizing soil and environmental degradation. References Anderson, D.W., E.G. Gregorich. 1984. Effect of soil erosion on soil quality and productivity. p. 105-113. In Soil erosion and degradation. Proc. 2nd Ann. 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