Sample records for hannu grhn matti

  1. Application of the Mattis-Bardeen theory in strongly disordered superconductors

    NASA Astrophysics Data System (ADS)

    Seibold, G.; Benfatto, L.; Castellani, C.

    2017-10-01

    The low-energy optical conductivity of conventional superconductors is usually well described by Mattis-Bardeen (MB) theory, which predicts the onset of absorption above an energy corresponding to twice the superconducing (SC) gap parameter Δ . Recent experiments on strongly disordered superconductors have challenged the application of the MB formulas due to the occurrence of additional spectral weight at low energies below 2 Δ . Here we identify three crucial items that have to be included in the analysis of optical-conductivity data for these systems: (a) the correct identification of the optical threshold in the Mattis-Bardeen theory and its relation with the gap value extracted from the measured density of states, (b) the gauge-invariant evaluation of the current-current response function needed to account for the optical absorption by SC collective modes, and (c) the inclusion into the MB formula of the energy dependence of the density of states present already above Tc. By computing the optical conductivity in the disordered attractive Hubbard model, we analyze the relevance of all these items, and we provide a compelling scheme for the analysis and interpretation of the optical data in real materials.

  2. Narratives in Teaching Practice: Matti Raekallio as Narrator in His Piano Lessons

    ERIC Educational Resources Information Center

    Hyry-Beihammer, Eeva Kaisa

    2011-01-01

    The present article considers the narratives told in piano lessons, studied as both a teacher's "way of knowing" and as echoes of "masters' voices" in classical music. The main character is a well known Finnish music pedagogue and artist, Matti Raekallio, and the study focuses on his knowledge of teaching practice; that is, his…

  3. Breakdown of the Wigner-Mattis theorem in semiconductor carbon-nanotube quantum dots

    NASA Astrophysics Data System (ADS)

    Rontani, Massimo; Secchi, Andrea; Manghi, Franca

    2009-03-01

    The Wigner-Mattis theorem states the ground state of two bound electrons, in the absence of the magnetic field, is always a spin-singlet. We predict the opposite result --a triplet- for two electrons in a quantum dot defined in a semiconductor carbon nanotube. The claim is supported by extensive many-body calculations based on the accurate configuration interaction code DONRODRIGO (www.s3.infm.t/donrodrigo). The crux of the matter is the peculiar two-valley structure of low-energy states, which encodes a pseudo-spin degree of freedom. The spin polarization of the ground state corresponds to a pseudo-spin singlet, which is selected by the inter-valley short-range Coulomb interaction. Single-electron excitation spectra and STM wave function images may validate this scenario, as shown by our numerical simulations.

  4. Exact Lyapunov exponent of the harmonic magnon modes of one-dimensional Heisenberg-Mattis spin glasses

    NASA Astrophysics Data System (ADS)

    Sepehrinia, Reza; Niry, M. D.; Bozorg, B.; Tabar, M. Reza Rahimi; Sahimi, Muhammad

    2008-03-01

    A mapping is developed between the linearized equation of motion for the dynamics of the transverse modes at T=0 of the Heisenberg-Mattis model of one-dimensional (1D) spin glasses and the (discretized) random wave equation. The mapping is used to derive an exact expression for the Lyapunov exponent (LE) of the magnon modes of spin glasses and to show that it follows anomalous scaling at low magnon frequencies. In addition, through numerical simulations, the differences between the LE and the density of states of the wave equation in a discrete 1D model of randomly disordered media (those with a finite correlation length) and that of continuous media (with a zero correlation length) are demonstrated and emphasized.

  5. Anomaly manifestation of Lieb-Schultz-Mattis theorem and topological phases

    NASA Astrophysics Data System (ADS)

    Cho, Gil Young; Hsieh, Chang-Tse; Ryu, Shinsei

    2017-11-01

    The Lieb-Schultz-Mattis (LSM) theorem dictates that emergent low-energy states from a lattice model cannot be a trivial symmetric insulator if the filling per unit cell is not integral and if the lattice translation symmetry and particle number conservation are strictly imposed. In this paper, we compare the one-dimensional gapless states enforced by the LSM theorem and the boundaries of one-higher dimensional strong symmetry-protected topological (SPT) phases from the perspective of quantum anomalies. We first note that they can both be described by the same low-energy effective field theory with the same effective symmetry realizations on low-energy modes, wherein non-on-site lattice translation symmetry is encoded as if it were an internal symmetry. In spite of the identical form of the low-energy effective field theories, we show that the quantum anomalies of the theories play different roles in the two systems. In particular, we find that the chiral anomaly is equivalent to the LSM theorem, whereas there is another anomaly that is not related to the LSM theorem but is intrinsic to the SPT states. As an application, we extend the conventional LSM theorem to multiple-charge multiple-species problems and construct several exotic symmetric insulators. We also find that the (3+1)d chiral anomaly provides only the perturbative stability of the gaplessness local in the parameter space.

  6. Screening for DSM-IV-TR Cognitive Disorder NOS in Parkinson’s disease using the Mattis Dementia Rating Scale

    PubMed Central

    Pontone, Gregory M.; Palanci, Justin; Williams, James R.; Bassett, Susan Spear

    2012-01-01

    Objective This study explores the utility of the Mattis Dementia Rating Scale (MDRS) as a screening tool for the Diagnostic and Statistical Manual for Mental Disorders 4th edition (DSM-IV-TR) diagnosis Cognitive Disorder Not Otherwise Specified in Parkinson’s disease(PD). Methods 125 individuals with PD were diagnosed using DSM-IV-TR criteria for Cognitive Disorder NOS and dementia. Receiver operating characteristics tested the discriminant validity of the MDRS, with the clinician’s diagnosis serving as the gold standard. Results The MDRS ROC curve to discriminate subjects with Cognitive Disorder NOS from non-demented subjects had an AUC of 0.59 (std. err.= 0.08, 95% CI: 0.43–0.74). Conclusions The MDRS is not effective for identifying PD patients with Cognitive Disorder NOS without dementia. PMID:22628158

  7. Mattis dementia rating scale (DRS) normative data for the brazilian middle-age and elderly populations.

    PubMed

    Foss, Maria Paula; de Carvalho, Viviane Amaral; Machado, Thais Helena; Dos Reis, Geraldo Cássio; Tumas, Vitor; Caramelli, Paulo; Nitrini, Ricardo; Porto, Cláudia Sellitto

    2013-01-01

    To expand norms for the Mattis Dementia Rating Scale (DRS) for the Brazilian middle-age and elderly populations. The DRS was administered to 502 individuals without cognitive deficits, 312 women and 190 men, aged 50 years or over and with educational level ranging from 0 to 13 years or more. The sample was composed of subjects who participated in other studies, from Caeté (Minas Gerais state), Ribeirão Preto (São Paulo state) and São Paulo (São Paulo state). Participants were divided into four schooling groups (illiterate, 1 to 4 years, 5 to 12 years and 13 years or more). The subjects were divided into four groups according to age (50 to 60, 61 to 70, 71 to 80, and 80 years or over). Normative data for DRS scores are expressed as percentile values. The group with lowest schooling and subjects older than 80 years had the worst scores. As expected, age and education were strongly correlated with DRS scores. Illiterates and older old individuals performed worse than the other groups. These data might help to improve the accuracy of the diagnosis of cognitive impairment and dementia in Brazilian middle-age and elderly populations.

  8. Mattis dementia rating scale (DRS) normative data for the brazilian middle-age and elderly populations

    PubMed Central

    Foss, Maria Paula; de Carvalho, Viviane Amaral; Machado, Thais Helena; dos Reis, Geraldo Cássio; Tumas, Vitor; Caramelli, Paulo; Nitrini, Ricardo; Porto, Cláudia Sellitto

    2013-01-01

    OBJECTIVE To expand norms for the Mattis Dementia Rating Scale (DRS) for the Brazilian middle-age and elderly populations. METHODS The DRS was administered to 502 individuals without cognitive deficits, 312 women and 190 men, aged 50 years or over and with educational level ranging from 0 to 13 years or more. The sample was composed of subjects who participated in other studies, from Caeté (Minas Gerais state), Ribeirão Preto (São Paulo state) and São Paulo (São Paulo state). Participants were divided into four schooling groups (illiterate, 1 to 4 years, 5 to 12 years and 13 years or more). The subjects were divided into four groups according to age (50 to 60, 61 to 70, 71 to 80, and 80 years or over). RESULTS Normative data for DRS scores are expressed as percentile values. The group with lowest schooling and subjects older than 80 years had the worst scores. CONCLUSION As expected, age and education were strongly correlated with DRS scores. Illiterates and older old individuals performed worse than the other groups. These data might help to improve the accuracy of the diagnosis of cognitive impairment and dementia in Brazilian middle-age and elderly populations. PMID:29213861

  9. Removal of graffiti paintings from the Mansion de Mattis site in Corato (Bari), Italy: Laser deveiling or complete cleaning?

    NASA Astrophysics Data System (ADS)

    Daurelio, G.; Andriani, E. S.; Albanese, A.; Catalano, I. M.; Teseo, G.; Marano, D.

    2008-10-01

    Nowadays one the main problem of stone monuments conservation is not only the natural environment deterioration but the defaced, in particular esthetic, due to graffiti. This paper presents the different stages of the cleaning graffiti research: the laboratory study phase, in which the aims were to investigate the laser cleaning effect on substrate and testing user-friendly and efficient solutions for in situ application; the application phase in which the study results were applied in the restoration of Palazzo de Mattis facade. The graffiti cleaning were carried out by using a Q-Switch Nd:YAG laser source (λ=1064 nm with pulse duration, t=8 ns, f=2 to 20 Hz, energy per impulse up to 280 mJ) in dry, wet and Very wet modes adopting the Daurelio technique n.1 (blade spot laser). The Q-Switch Nd:Yag laser source has demonstrated to be the most suitable for a fully or, according to new restoring theory, "de veiling" graffiti ablation.

  10. High efficiency transformation of banana [Musa acuminata L. cv. Matti (AA)] for enhanced tolerance to salt and drought stress through overexpression of a peanut salinity-induced pathogenesis-related class 10 protein.

    PubMed

    Rustagi, Anjana; Jain, Shalu; Kumar, Deepak; Shekhar, Shashi; Jain, Mukesh; Bhat, Vishnu; Sarin, Neera Bhalla

    2015-01-01

    Bananas and plantains (Musa spp. L.) are important subsistence crops and premium export commodity in several countries, and susceptible to a wide range of environmental and biotic stress conditions. Here, we report efficient, rapid, and reproducible Agrobacterium-mediated transformation and regeneration of an Indian niche cultivar of banana [M. acuminata cv. Matti (AA)]. Apical meristem-derived highly proliferative multiple shoot clump (MSC) explants were transformed with the Agrobacterium strain EHA105 harboring a binary vector pCAMBIA-1301 carrying hptII and uidA. Sequential agro-infiltration (10 min, 400 mmHg), infection (additional 35 min, Agrobacterium density A 600 = 0.8) and co-cultivation (18 h) regimen in 100 µM acetosyringone containing liquid medium were critical factors yielding high transformation efficiency (~81 %) corroborated by transient GUS expression assay. Stable transgenic events were recovered following two cycles of meristem initiation and selection on hygromycin containing medium. Histochemical GUS assay in several tissues of transgenic plants and molecular analyses confirmed stable integration and expression of transgene. The protocol described here allowed recovery of well-established putative transgenic plantlets in as little as 5 months. The transgenic banana plants could be readily acclimatized under greenhouse conditions, and were phenotypically similar to the wild-type untransformed control plants (WT). Transgenic plants overexpressing Salinity-Induced Pathogenesis-Related class 10 protein gene from Arachis hypogaea (AhSIPR10) in banana cv. Matti (AA) showed better photosynthetic efficiency and less membrane damage (P < 0.05) in the presence of NaCl and mannitol in comparison to WT plants suggesting the role of AhSIPR10 in better tolerance of salt stress and drought conditions.

  11. [Production of accentuated personality traits in baroque opera : Opera buffa Arcifanfano-Re dei matti (1749)].

    PubMed

    Brunner, J; Hirsch, T; Steger, F

    2016-05-01

    Madness served primarily as a form of amusement for the spectators in operas of the seventeenth century. This representation was far removed from clinical reality. This circumstance changed in the eighteenth century at the time when tragic madness emerged in numerous operas. The opera buffa Arcifanfano-Re dei matti (Arcifanfano-King of fools, premiered in 1749 in Venice, text by Carlo Goldoni 1707-1793 and music by Baldassare Galuppi 1706-1785), which continuously enacts a realm of fools and is meant to appear amusing, is riddled with psychopathological abnormalities for which a retrospective diagnosis is methodologically rejected. However, the opera presents many subjects for working out a typology of fools based on outlasting personality traits of the protagonists. The libretto is investigated. A musical analysis is spared. The conceptualized typology of fools in the opera, which is oriented towards the seven main vices or deadly sins serves, in the tradition of moral satire, to critically hold up a mirror to the audience to reflect their own vices by an amusing characterization of the latter. Historically classified, the treatment of fools by means of isolation, custody, locking up in cages as well as authoritarian measures of submission reflects the custom in those days before humanizing the treatment of people with mental illness in the course of the Enlightenment and the French Revolution. The opera Arcifanfano is essentially characterized by continuous madness. A typology of the fools can be worked out from the precise depiction of the personalities. A mirror is held up to the spectators in terms of vices, in the tradition of the contemporary baroque opera. At the same time, the opera can be classified psychiatrically and historically as a seismograph of its time when in the seventeenth and eighteenth centuries people with mental illness were isolated and incarcerated.

  12. Assistant Secretary of Defense for Legislative Affairs

    Science.gov Websites

    Links Mission Congressional Links Secretary of Defense James Mattis
    James Mattis" title=" Secretary of Defense James Mattis" /> The

  13. Spanish version of the Mattis Dementia Rating Scale-2 for early detection of Alzheimer's disease and mild cognitive impairment.

    PubMed

    Boycheva, Elina; Contador, Israel; Fernández-Calvo, Bernardino; Ramos-Campos, Francisco; Puertas-Martín, Verónica; Villarejo-Galende, Alberto; Bermejo-Pareja, Félix

    2018-06-01

    We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI-single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS-2 (total and subscales) were analysed. The MDRS-2 scores, adjusted by socio-demographic characteristics, were calculated through hierarchical multiple regression analysis. The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p < .001) with the Mini-Mental State Examination. The optimal cut-off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut-off point between MCI and HCs. An optimal cut-off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups. The MDRS-2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  14. Proceedings of the 2010 AFMS Medical Research Symposium. Volume 4. Force Health Protection Track: Abstracts and Presentations

    DTIC Science & Technology

    2011-03-15

    of emerging threats for in-garrison or deployed operations. Topics of interest include research in bio -surveillance, infectious disease, emerging...Saber Hussain, Laura Braydich-Stolle, Nicole Schaeublin, David Mattie (Presented by Dr. David Mattie ) Recent developments have generated a degree...Evaluation of Jet Fuel Inducted Hearing Loss in Rats 711th Human Performance Wing (HPW)/RHPA David Mattie , PhD Noise-induced hearing loss (NIHL

  15. Hybrid Threat Center of Gravity Analysis: Cutting the Gordian Knot

    DTIC Science & Technology

    2016-04-04

    U.S. Marine Corps General James Mattis summed this best when he stated that “we expect future enemies to look at the four approaches [Traditional...synthesis is what we call hybrid warfare.”15 15 James N. Mattis and Frank Hoffman, "Future...accoun tid=12686 (accessed August 16, 2015). Mattis , James N. and Frank Hoffman. "Future Warfare: The Rise of Hybrid wars." United States Naval

  16. Missile Defense Acquisition: Failure Is Not An Option

    DTIC Science & Technology

    2016-01-26

    Missile Defense Acquisition: Failure is Not an Option 8 capabilities. Retired Marine General James Mattis ’ renowned quote rings true, “The enemy...american-missile-defense-why-failure-is- an-option. 18 Vago Muradian, “Interview: Gen. James Mattis , Commander, U.S. Joint Forces Command,” 23 May...2010, http://archive.defensenews.com/article/20100523/DEFFEAT03/5230301/Gen- James - Mattis . 19 Institute for Defense Analyses, p. II-3. 20 Missile

  17. The Glass Ceiling - A Question of Joint Officer Development - Why Only Five USAF Geographic Combatant Commanders?

    DTIC Science & Technology

    2010-07-26

    kit/OEF.asp (accessed March 6, 2011). 19 U.S. Central Command. "US CENTCOM Leadership: General James N. Mattis , Commander,‖ http... Mattis , USMC Commander, USCENTCOM 0 2 Cmdr, Task Force 58 Cmdr, USJFCOM Admiral James G. Stavridis, USN Commander, USEUCOM 1 2 Plans Officer, JCS...U.S. Central Command. "US CENTCOM Leadership." General James N. Mattis . https://slsp.http://www.centcom.mil/en/about-centcom/leadership

  18. The Role of Special Operations Forces in Global Competition

    DTIC Science & Technology

    2016-04-01

    Third, U.S. strategic objectives are likely to change in the short term. In January 2015, General James N. Mattis (then retired) spoke before the...from 13 Years of War. RR-816-A. [36] General James N. Mattis , USMC (Ret.). Global Challenges and U.S. National Security Strategy. 114th Congress... Mattis made these comments two years before becoming secretary of defense in 2017. Given his statements, he will likely attempt to change the current

  19. Reorganizing Geographic Combatant Command Headquarters for Joint Force 2020

    DTIC Science & Technology

    2013-05-01

    Corps General James N. Mattis , U.S. Central Command Commander, before the House Armed Services Committee on March 7, 2012, about the posture of U.S...Prentice Hall, 2002. Legal Organization of Defense. http://www.ndu.edu/library/pbrc/36L52.pdf (accessed January 21, 2013). 99 Mattis , James N...Statement of U.S. Marine Corps General James N. Mattis , U.S. Central Command Commander, before the House Armed Services Committee on March 7, 2012

  20. Sensitivity and specificity of Addenbrooke's Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson's disease.

    PubMed

    Kaszás, B; Kovács, N; Balás, I; Kállai, J; Aschermann, Z; Kerekes, Z; Komoly, S; Nagy, F; Janszky, J; Lucza, T; Karádi, K

    2012-06-01

    Among the non-motor features of Parkinson's disease (PD), cognitive impairment is one of the most troublesome problems. Highly sensitive and specific screening instruments for detecting dementia in PD (PDD) are required in the clinical practice. In our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke's Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinson's disease patients without depression. By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD. Best cut-off score for ACE to identify PDD was 80 points (sensitivity = 74.0%, specificity = 78.1%). For FAB the most optimal cut-off value was 12 points (sensitivity = 66.3%, specificity = 72.2%); whereas for MDRS it was 125 points (sensitivity = 89.8%, specificity = 98.3%). Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD. Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. Our results demonstrated that the specificity and sensitivity of MDRS was better than those of ACE, FAB and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. First Calderón Prize

    NASA Astrophysics Data System (ADS)

    Rundell, William; Somersalo, Erkki

    2008-07-01

    The Inverse Problems International Association (IPIA) awarded the first Calderón Prize to Matti Lassas for his outstanding contributions to the field of inverse problems, especially in geometric inverse problems. The Calderón Prize is given to a researcher under the age of 40 who has made distinguished contributions to the field of inverse problems broadly defined. The first Calderón Prize Committee consisted of Professors Adrian Nachman, Lassi Päivärinta, William Rundell (chair), and Michael Vogelius. William Rundell For the Calderón Prize Committee Prize ceremony The ceremony awarding the Calderón Prize. Matti Lassas is on the left. He and William Rundell are on the right. Photos by P Stefanov. Brief Biography of Matti Lassas Matti Lassas was born in 1969 in Helsinki, Finland, and studied at the University of Helsinki. He finished his Master's studies in 1992 in three years and earned his PhD in 1996. His PhD thesis, written under the supervision of Professor Erkki Somersalo was entitled `Non-selfadjoint inverse spectral problems and their applications to random bodies'. Already in his thesis, Matti demonstrated a remarkable command of different fields of mathematics, bringing together the spectral theory of operators, geometry of Riemannian surfaces, Maxwell's equations and stochastic analysis. He has continued to develop all of these branches in the framework of inverse problems, the most remarkable results perhaps being in the field of differential geometry and inverse problems. Matti has always been a very generous researcher, sharing his ideas with his numerous collaborators. He has authored over sixty scientific articles, among which a monograph on inverse boundary spectral problems with Alexander Kachalov and Yaroslav Kurylev and over forty articles in peer reviewed journals of the highest standards. To get an idea of the wide range of Matti's interests, it is enough to say that he also has three US patents on medical imaging applications. Matti is

  2. Radio Frequency Controlled Stimulation of Intracellular Gold or Silver Nanoparticle Conjugates for Use as Potential Sensors or Modulators of Biological Function

    DTIC Science & Technology

    2010-09-01

    SIGNED//___________ DAVID R. MATTIE , PhD, DR-III...RESPONSIBLE PERSON David R. Mattie a. REPORT U b. ABSTRACT U c. THIS PAGE U SAR 72 19b. TELEPHONE...used as a cellular model to determine the interaction of NPs with human skin. HaCaT cells were donated generously by Dr. James F. Dillman III, of the

  3. An Alternative Way of Responding to Powerful Ideas: Notes to Accompany the Poem Entitled "Five Principles of Quality in Narratives of Action Research"

    ERIC Educational Resources Information Center

    Saunders, Lesley

    2007-01-01

    This paper is written in a personal capacity and mainly takes the form of a poem--in five sections--composed as a response to some of the ideas in the article by Hannu Heikkinen and colleagues in this same issue of "Educational Action Research": "Action research as narrative: five principles for validation". The poem takes its…

  4. Al Sahawa - The Awakening: An Education and Training Resource Guide

    DTIC Science & Technology

    2015-07-01

    Hadithah, and Hit to work with the tribes and develop those relationships from the bottom up. In fact, Major General James Mattis , 1st Marine Division...conditions for the awakening in Ramadi through tribal connections, in- 11 This includes James ...mid-2004. According to Mattis ’ account, Major Such and the efforts of these isolated SF detachments “actually began what eventually morphed into the

  5. Special Inspector General for Afghanistan Reconstruction (SIGAR) Quarterly Report to the United States Congress

    DTIC Science & Technology

    2012-10-30

    James Mattis , Commander of CENTCOM, and General John Allen, Commander of the International Security Assistance Force (ISAF) warning that Afghan con...September 17, 2012, CENTCOM commander General James N. Mattis advised DoD heads of contracting to avoid contracting with 20 individuals and entities...Admiral James Stavridis, at Panetta’s left. NATO Secretary General Anders Fogh Rasmussen stands at Panetta’s right. (DoD photo) SPECIAL INSPECTOR GENERAL

  6. Biocompatibility and Toxicological Effects of Doped, Functionalized and Pure Carbon Nanotubes

    DTIC Science & Technology

    2009-08-25

    0; Mattie , David, M. 1-,,- 0,",," ONIT NUMBER- IPICyT, Camino a la Presa San Jose 2055, Col. Lomas 41a. seox., San Luis Polosi , SLP 78250, Mexico... Mattie , D.M., Schlager, J.J. and Terrones, M. (2008) “Toxicity Evaluation for Safe Use of Nanomaterials: Recent Achievements and Technical...In vitro & In vivo studies Bio Effect Predictive Modeling Nanotoxicoinformatics Toxicity Q1: Do the NM come into contact with & enter cell

  7. Army Network-Enabled Operations: Expectations, Performance, and Opportunities for Future Improvements

    DTIC Science & Technology

    2012-01-01

    trusted the ability of the Army networks to alert him to the presence of significant ground threats. Similarly, then–MG James Mattis was confident that he...CJTF and Component Essential Capability Analysis, draft briefing, August 2, 2004. Mattis , LtGen. James N., U.S. Marine Corps, and LtCol. (Ret...Hattie Bouyer in Headquarters, Depart- ment of the Army, Office of the Chief Information Officer/G-6. We are indebted to James Cooke and Colonel Chris

  8. Acute Dermal Irritation Study of Six Jet Fuels in New Zealand White Rabbits: Comparison of Four Bio-Based Jet Fuels with Two Petroleum JP-8 Fuels

    DTIC Science & Technology

    2014-02-01

    NA 5c. PROGRAM ELEMENT NUMBER 62202F 6. AUTHOR(S) Sterner, Teresa R.1; Hurley, Jonathon M.2; Edwards, James T.3; Shafer, Linda M.4; Mattie , David R... Mattie , D.R. 2014. Acute Dermal Irritation Study of Ten Jet Fuels in New Zealand White Rabbits: Comparison of Synthetic and Bio -Based Jet Fuels with...AFRL-RH-WP-TR-2014-0046 ACUTE DERMAL IRRITATION STUDY OF SIX JET FUELS IN NEW ZEALAND WHITE RABBITS: COMPARISON OF FOUR BIO -BASED JET FUELS

  9. Designing Graphic Presentations from First Principles

    DTIC Science & Technology

    1998-01-01

    Khanna, Rahul Asthana, Pascale Fung, and Joanna Sadowska. Others, once near but now far, included: Ivelina Zlateva, Robert Chang, Anna Herreras , John...For example, Roth & Mattis (1990) propose characterizing data in terms of cardinality , coverage and uniqueness. Cardinality allows data to be

  10. Tanker Fuel Efficiency: Saving Through Receiver Fuel Planning

    DTIC Science & Technology

    2014-06-13

    engage your weapon.” General James Mattis , 2003 Conclusions The current planning and execution of air refueling missions are costing the DOD...fuel cells, and bio fuels are being explored by scientists and engineers working to reduce the United States’ dependency on foreign oil (Harmon

  11. Benchmarking Peer Production Mechanisms, Processes & Practices

    ERIC Educational Resources Information Center

    Fischer, Thomas; Kretschmer, Thomas

    2008-01-01

    This deliverable identifies key approaches for quality management in peer production by benchmarking peer production practices and processes in other areas. (Contains 29 footnotes, 13 figures and 2 tables.)[This report has been authored with contributions of: Kaisa Honkonen-Ratinen, Matti Auvinen, David Riley, Jose Pinzon, Thomas Fischer, Thomas…

  12. Provincial Reconstruction Teams: Who’s in Charge?

    DTIC Science & Technology

    2011-05-20

    permission of General Mattis. 41 U.S. President, NSPD-44. 42 Stephen R. Covey, The 7 Habits of Highly Effective People , (New York: Simon & Schuster...September 5, 2010). Covey, Stephen R. The 7 Habits of Highly Effective People . New York: Simon & Schuster, Inc., 1990. Crane, Conrad C. and W

  13. Office of the Under Secretary of Defense for Personnel and Readiness

    Science.gov Websites

    Mattis, Danish Defense Minister Reaffirm Defense Relationship Fri, 25 May 2018 19:25:00 GMT Trump Thanks Deputy Secretary of Defense for Total Force Management as it relates to readiness; National Guard and Reserve component affairs; health affairs; training; and personnel requirements and management, including

  14. Learning Science through Talking Science in Elementary Classroom

    ERIC Educational Resources Information Center

    Tank, Kristina Maruyama; Coffino, Kara

    2014-01-01

    Elementary students in grade two make sense of science ideas and knowledge through their contextual experiences. Mattis Lundin and Britt Jakobson find in their research that early grade students have sophisticated understandings of human anatomy and physiology. In order to understand what students' know about human body and various systems,…

  15. Outside the Golden Gate: Prospects and Comparisons in Finnish Adult Higher Education.

    ERIC Educational Resources Information Center

    Parjanen, Matti, Ed.; And Others

    This book contains four articles on adult higher education (AHE) in Finland. In the preface, Matti Parjanen outlines the development of AHE in Finland and discusses the rationale for the book. In "Adult Education and Universities in the Era of Economic Depression," Osmo Kivinen and Risto Rinne examine the dilemma between the mission of…

  16. Quantifying Enhanced Microbial Dehalogenation Impacting the Fate and Transport of Organohalide Mixtures in Contaminated Sediments

    DTIC Science & Technology

    2012-02-01

    supplying Anacostia River sediment, Dr. Matti Verta, Finnish Environment Institute, for providing Kymijoki River sediment, and the Meadowlands...dehalogenating activity; 2) Characterize the effect of sedimentary conditions on the ( bio )transformation rates of organohalide mixtures and their...the fate and transport of organohalide contaminants, co-amendments and ( bio )transformation products under various bioremediation scenarios. The

  17. Effect of interstitial impurities on the field dependent microwave surface resistance of niobium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martinello, M., E-mail: mmartine@fnal.gov; Checchin, M.; Department of Physics, Illinois Institute of Technology, Chicago, Illinois 60616

    Previous work has demonstrated that the radio frequency surface resistance of niobium resonators is dramatically reduced when nitrogen impurities are dissolved as interstitial in the material. This effect is attributed to the lowering of the Mattis-Bardeen surface resistance with increasing accelerating field; however, the microscopic origin of this phenomenon is poorly understood. Meanwhile, an enhancement of the sensitivity to trapped magnetic field is typically observed for such cavities. In this paper, we conduct a systematic study on these different components contributing to the total surface resistance as a function of different levels of dissolved nitrogen, in comparison with standard surfacemore » treatments for niobium resonators. Adding these results together, we are able to show which is the optimum surface treatment that maximizes the Q-factor of superconducting niobium resonators as a function of expected trapped magnetic field in the cavity walls. These results also provide insights on the physics behind the change in the field dependence of the Mattis-Bardeen surface resistance, and of the trapped magnetic vortex induced losses in superconducting niobium resonators.« less

  18. Effect of interstitial impurities on the field dependent microwave surface resistance of niobium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martinello, M.; Grassellino, A.; Checchin, M.

    Previous work has demonstrated that the radio frequency surface resistance of niobium resonators is dramatically reduced when nitrogen impurities are dissolved as interstitial in the material. The origin of this effect is attributed to the lowering of the Mattis and Bardeen surface resistance contribution with increasing accelerating field. Meanwhile, an enhancement of the sensitivity to trapped magnetic field is typically observed for such cavities. In this paper we conduct the first systematic study on these different components contributing to the total surface resistance as a function of different levels of dissolved nitrogen, in comparison with standard surface treatments for niobiummore » resonators. Adding these results together we are able to show for the first time which is the optimum surface treatment that maximizes the Q-factor of superconducting niobium resonators as a function of expected trapped magnetic field in the cavity walls. Lastly, these results also provide new insights on the physics behind the change in the field dependence of the Mattis and Bardeen surface resistance, and of the trapped magnetic vortex induced losses in superconducting niobium resonators.« less

  19. Effect of interstitial impurities on the field dependent microwave surface resistance of niobium

    DOE PAGES

    Martinello, M.; Grassellino, A.; Checchin, M.; ...

    2016-08-09

    Previous work has demonstrated that the radio frequency surface resistance of niobium resonators is dramatically reduced when nitrogen impurities are dissolved as interstitial in the material. The origin of this effect is attributed to the lowering of the Mattis and Bardeen surface resistance contribution with increasing accelerating field. Meanwhile, an enhancement of the sensitivity to trapped magnetic field is typically observed for such cavities. In this paper we conduct the first systematic study on these different components contributing to the total surface resistance as a function of different levels of dissolved nitrogen, in comparison with standard surface treatments for niobiummore » resonators. Adding these results together we are able to show for the first time which is the optimum surface treatment that maximizes the Q-factor of superconducting niobium resonators as a function of expected trapped magnetic field in the cavity walls. Lastly, these results also provide new insights on the physics behind the change in the field dependence of the Mattis and Bardeen surface resistance, and of the trapped magnetic vortex induced losses in superconducting niobium resonators.« less

  20. Speech Research.

    DTIC Science & Technology

    1979-12-31

    629. Mattis, S., French, J. H., & Rapin, I. Dyslexia in children and young adults: Three independent neuropsychological syndromes. Developmental...Knights & D. K. Bakker (Eds.), Neuropsychology ofA learning disorders: Theoretical approaches. Baltimore: University Park Press, 1976. Shankweiler...sounds connected with comfort, discomfort, and hunger . When babbling appears, it is mixed in with cooing but distinguished by its syllable-like

  1. The US Army and Security Force Assistance: Assessing the Need for an Institutionalized Advisory Capability

    DTIC Science & Technology

    2009-03-03

    Army Special Forces. Following a 2008 meeting with Gen James N. Mattis (Commander, US Joint Forces Command), Gen James T. Conway (Commandant, US...CAPABILITY Approved by: , Thesis Committee Chair James B. Martin, Ph.D. , Member Gary J. Bjorge, Ph.D. , Member Robert D...Technology: Information technology, bio -technology, weaponry, increased access to information Demographic Changes: Population growth, youth bulge

  2. Official Website of the Joint Chiefs of Staff

    Science.gov Websites

    Corps photo by Lance Cpl. Haley McMenamin May 22, 2018 - Fitness means more than just passing a test Australia's Chief of Defence Did You Know We're on Instagram? Check out our latest post! Check out our latest Instagram post! #GenDunford and #SecDef Mattis brief reporters on the U.S., French and UK coordinated

  3. Setting the Scene--Introduction to Quality in Peer Production of eLearning

    ERIC Educational Resources Information Center

    Auvinen, Ari-Matti

    2008-01-01

    The "Setting the scene" deliverable of the QMPP project (www.qmpp.net) has been authored by Mr. Ari-Matti Auvinen (HCI Productions Oy) and many QMPP project partners. In addition to the definition of the scope of the project, it includes also a good list of references to the literature of user-generated content as well as good web links…

  4. Beyond-the-Box Thinking on Future War: The Art and Science of Unrestricted Warfare

    DTIC Science & Technology

    2009-04-01

    Studies Institute, US Army War College, 2008. Mattis , James N., and Frank Hoffman. “Future Warfare: The Rise of Hybrid Warfare.” Proceedings...nanotechnologies will augment the current bio -chemical capabilities, moving the battlefield into a microscopic arena. As seen before, the traditional American way...Military Trans-military Non-military Atomic Warfare Diplomatic Warfare Financial Warfare Conventional Warfare Network Warfare Trade Warfare Bio

  5. Hawaii-Hyperspectral Airborne Remote Environmental Sensing (HIHARES󈧍) Experiment

    DTIC Science & Technology

    2012-03-15

    Polynesia and southeastern Asia. Cordia sebestena Kou haole Found worldwide, mostly in warmer regions. Cordyline fruticosa Ti plant It is native to...to obtain spectra of vegetation indigenous to Oahu and from several specialty gardens, spectra of plants common to Australia. Hawaii Coastal...indigenous to Oahu and from several specialty gardens, spectra of plants common to Australia. On November 19, 2008, Dr. Chip Bachmann, Mssrs Mattis and

  6. Hydroprocessed Esters and Fatty Acids (HEFA) Bio-Based Jet Fuels: Sensory Irritation Study and Human Health Hazard Assessment

    DTIC Science & Technology

    2013-06-30

    AFRL-RH-FS-TR-2014-0001 Hydroprocessed Esters and Fatty Acids (HEFA) Bio -Based Jet Fuels: Sensory Irritation Study and Human Health Hazard...Karen L. Mumy Brian A. Wong R. Arden James James Reboulet Brian Sharits Michael Grimm Nathan Gargas Naval Medical Research Unit - Dayton...Wright-Patterson AFB OH Richard C. Striebich AFRL/RQTF Wright-Patterson AFB OH David R. Mattie Bioeffects Division Molecular Bioeffects Branch

  7. High Frontier - The Journal for Space, Cyberspace & Missile Professionals. Volume 6, Number 1, November 2009

    DTIC Science & Technology

    2009-11-01

    signs of just that!” In a response sent several days following Van Riper’s e-mail, [US Marine Corp Lt Gen James ] Mattis —who is now in the post Van...29 Regaining Credibility: Making Nuclear Sustainment a Model of Excellence Col James D. Fisher...Taverney, retired and Col James D. Rendleman, retired . . . . . . 53 Legislative Perspective Weapon Systems Acquisition Reform Act Maj Jung H. Ha

  8. The National Guard: Recommendations to Develop the Joint Future Force

    DTIC Science & Technology

    2010-03-01

    0209airpowerinafghan.pdf. 23 Statement of General James N. Mattis , USMC, Commander, United States Joint Forces Command, House Armed Services... James R. Locher III, Victory on the Potomac: the Goldwater-Nichols Act Unifies the Pentagon, (College Station: Texas A & M University Press, 2002), 19...pick snubs National Guard, Thursday January 14, 2010, Congress.org, http://www.congress.org/congressorg/ bio /userletter/?letter_id=4520675821

  9. Evolution of the Air Component Commander Post Goldwater-Nichols

    DTIC Science & Technology

    2013-06-01

    example, before Brigadier General James Mattis led Marine forces in the taking of Kandahar, he spoke with Moseley; and they agreed to conduct the...These separated commands and the division of airpower, along 3 James A. Winnefeld and Dana J...Biography: Lieutenant General Michael C. Short,” July 2000., http://www.af.mil/information/ bios /bio.asp?bioID=7136 (accessed March 20, 2013). 27 Short

  10. Center for Development of Security Excellence (CDSE) 2013 Year End Report

    DTIC Science & Technology

    2013-01-01

    Humphrey Deputy Director, CDSE CDSE STATEMENT Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nunc bibendum dapibus dui, at porta nunc. In eget...accumsan odio. Donec rutrum varius purus, vitae venenatis urna porttitor eget. Mauris lorem dolor , facilisis eget purus quis, adipiscing tincidunt...ac quam at gravida. Cras a ligula suscipit, lobortis dolor vel, feugiat diam. Proin mattis lectus sit amet pellentesque interdum. Cras porttitor

  11. MicroRNAs in Prostate Cancer

    DTIC Science & Technology

    2008-11-01

    microarray, gene expression, androgen 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18 . NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...Anindya Dutta; Yong Sun Lee; Hak Kyun Kim MicroRNAs are short single-stranded RNAs of 18 -22 bases length that are produced by the processing of...we hope to go to xenograft assays to demonstrate that microRNA alterations can suppress metastasis. REFERENCES: 1. Mattie, M.D., et al

  12. Agent-Based Modeling and Simulation: Proposal for Department of Defense Support to the Whole of Government Approach In Afghanistan

    DTIC Science & Technology

    2012-05-11

    September 1, 2011). 5 Abraham Maslow , Motivation and Personality, Third Edition, Harper and Row Publishers, 1954, 91-236. 6 Joshua M. Epstein, “Why...Response Program." Joint Force Quarterly, no. 37 (2005): 46, http://www.dtic.mil/doctrine/jel/jfq_pubs/0937.pdf (accessed October 15, 2011). Maslow ... Abraham . Motivation and Personality. Third ed. New York, New York: Harper and Row, 1954. Mattis, James. US Central Command Commander’s Posture

  13. Mathematical Model of HIF-1 alpha Pathway, Oxygen Transport and Hypoxia

    DTIC Science & Technology

    2017-09-01

    interpret experimental data in terms of underlying mechanisms. Such experiments, if quantitative , can also be used to calibrate and further parameterize...Wing Air Force Research Laboratory Wright-Patterson AFB OH 45433-5707 STINFO COPY Work Unit Manager MATTIE.DAV ID.R.123010 1880 Digitally signed by...MONITORING AGENCY NAME(S) AND ADDRESS(ES) Air Force Materiel Command* Air Force Research Laboratory 711th Human Performance Wing Human Effectiveness

  14. Systems Theory, Unity of Effort, and Military Leadership

    DTIC Science & Technology

    2012-12-14

    adventure, and without you, all else is meaningless. To my Daddy, LTC (R) James R. Livingood. I am who I am, because of you. You taught me to question...decisions as applied within his localized operational environment (Headquarters, Department of the Army 2012b). 6General Mattis and others argue that...systems network theory have made incredible steps forward in the past few years, through the work of social scientists Nicholas Christakis and James

  15. KITAE II: Knowledge Development in Battlespace Helmand

    DTIC Science & Technology

    2011-06-01

    Sergeant Andrew James Jones 18-09-2010 Private Simon Mundt Jørgensen 22-09-2010 Corporal Matthew Thomas 25-09-2010 Rifleman Suraj Gurung 02-10-2010...targeting driven. See Mattis (2008); For philosophical foundation see Smith (2005, 2006); Nicholson (2006);Mitchell (2004); and a doctrinal...BATTLESPACE IS THE KNOWLEDGE BASE HUMINT 1 SIGINT1 OSINT BIO IMINT 1 SIGINT 2 PATROLS HUMINT 2 REACHBACK IMINT 2 Sources OTHER… Actionable Assets Organic

  16. Capability Surprise (Report of the Defense Science Board 2008 Summer Study). Volume 1: Main Report

    DTIC Science & Technology

    2009-09-01

    fact, this has already happened, at least to a degree. Gen. James Mattis sent a memo in March 2009 to Defense Secretary Robert Gates calling for the... bio , but with a focus on threats to military operations, we chose not to. “Surprising” surprises—those many that the nation might have known about...Victor 3/Akula Quieting Undetected use of foreign technology Prepared because we had anticipated capability in general Soviet Bio -weapons Program

  17. Building Security in the Persian Gulf

    DTIC Science & Technology

    2010-01-01

    developments within ACT, and building on the leadership and success of the outgoing U.S. commander, General James Mattis , U.S. Marine Corps (who retains...following the end of the war in Iraq. The author would like to thank RAND President James Thomson, who supported the development of a proj- ect plan designed...bers from diverse issue backgrounds, all of whom have extensive experience both in research and in policy formulation. These were David Aaron, James

  18. MicroRNA-200c: A Novel Way to Attack Breast Cancer Metastases by Restoring the Epithelial Phenotype

    DTIC Science & Technology

    2012-12-01

    65:7065- 7070. 3. Mattie , M.D., Benz, C.C., Bowers, J., Sensinger, K., Wong, L., Scott, G.K., Fedele, V., Ginzinger, D., Getts, R., and Haqq, C...50 μg by Bradford protein assay ( Bio - Rad, Hercules, CA, USA), separated by SDS-PAGE gels and transferred onto polyvinylidene difluoride (PVDF...Richer), and the National Institutes of Health R01CA74285 (D. Yee).We thank Aik-Choon Tan (University of Colorado, Division of Medical Oncology) for bio

  19. JPRS Report West Europe

    DTIC Science & Technology

    1988-08-12

    that first graders are the nicest, like all in one big family. Well-behaved and obedient. Maybe Matti teases Maija a little bit and Pekka pushes Kalle ...France as early as 1971 . The system designed for Finland is an all-weather ver- sion and it was originally intended to specifically destroy low-flying...ISTAT study covers principally the three years of 1984-86, but also examines the evolution of crime in Italy since 1971 . And this could not have

  20. Airmindedness Without Airheadedness: A Way Ahead for Airmen to Lead Design

    DTIC Science & Technology

    2013-02-14

    officers from any Service. 18 Notes 1. Edward C. Cardon and Lieutenant Colonel Steve Leonard, “Unleashing Design: Planning and the Art of...SAASS], 2006), 82.) 12. General James N. Mattis, Memorandum for U.S. Joint Forces Command, 9 October 2009. 13. Cardon and Leonard, “Unleashing...Design,” 3. See also Grant Martin, “A Tale of Two Design Efforts (and why they both Failed in Afghanistan),” Small Wars Journal (July 7, 2011): 1-15

  1. Evaluation of the Occupational Risks from Jet Fuel (Toxicity Screening Battery)

    DTIC Science & Technology

    2012-09-01

    1α may serve as a marker of epidermal damage or stress due to irritation in this in vitro model. As an alternative to the 3-dimensional human skin...AFRL-RH-FS-SR-2013-0003 Final Report: Evaluation of the Occupational Risks from Jet Fuel (Toxicity Screening Battery) David R. Mattie...2. REPORT TYPE Special Report 3. DATES COVERED (From - To) Oct 2010 – Dec 2011 4. TITLE AND SUBTITLE Evaluation of the Occupational Risks from

  2. A resolution honoring the extraordinary and courageous life of Mattie Stepanek.

    THOMAS, 113th Congress

    Sen. Mikulski, Barbara A. [D-MD

    2014-07-21

    Senate - 07/21/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  3. Theory of disordered unconventional superconductors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Keles, A.; Andreev, A. V.; Spivak, B. Z., E-mail: spivak@uw.edu

    In contrast to conventional s-wave superconductivity, unconventional (e.g., p- or d-wave) superconductivity is strongly suppressed even by relatively weak disorder. Upon approaching the superconductormetal transition, the order parameter amplitude becomes increasingly inhomogeneous, leading to effective granularity and a phase ordering transition described by the Mattis model of spin glasses. One consequence of this is that at sufficiently low temperatures, between the clean unconventional superconducting and the diffusive metallic phases, there is necessarily an intermediate superconducting phase that exhibits s-wave symmetry on macroscopic scales.

  4. Sizing up the competition: quantifying the influence of the mental lexicon on auditory and visual spoken word recognition.

    PubMed

    Strand, Julia F; Sommers, Mitchell S

    2011-09-01

    Much research has explored how spoken word recognition is influenced by the architecture and dynamics of the mental lexicon (e.g., Luce and Pisoni, 1998; McClelland and Elman, 1986). A more recent question is whether the processes underlying word recognition are unique to the auditory domain, or whether visually perceived (lipread) speech may also be sensitive to the structure of the mental lexicon (Auer, 2002; Mattys, Bernstein, and Auer, 2002). The current research was designed to test the hypothesis that both aurally and visually perceived spoken words are isolated in the mental lexicon as a function of their modality-specific perceptual similarity to other words. Lexical competition (the extent to which perceptually similar words influence recognition of a stimulus word) was quantified using metrics that are well-established in the literature, as well as a statistical method for calculating perceptual confusability based on the phi-square statistic. Both auditory and visual spoken word recognition were influenced by modality-specific lexical competition as well as stimulus word frequency. These findings extend the scope of activation-competition models of spoken word recognition and reinforce the hypothesis (Auer, 2002; Mattys et al., 2002) that perceptual and cognitive properties underlying spoken word recognition are not specific to the auditory domain. In addition, the results support the use of the phi-square statistic as a better predictor of lexical competition than metrics currently used in models of spoken word recognition. © 2011 Acoustical Society of America

  5. The Therapeutic "Mis"conception: An Examination of its Normative Assumptions and a Call for its Revision.

    PubMed

    Mathews, Debra J H; Fins, Joseph J; Racine, Eric

    2018-01-01

    Dissecting Bioethics, edited by Tuija Takala and Matti Hayry, welcomes contributions on the conceptual and theoretical dimensions of bioethics. The department is dedicated to the idea that words defined by bioethicists and others should not be allowed to imprison people's actual concerns, emotions, and thoughts. Papers that expose the many meanings of a concept, describe the different readings of a moral doctrine, or provide an alternative angle to seemingly self-evident issues are particularly appreciated. To submit a paper or to discuss a suitable topic, contact Tuija Takala at tuija.takala@helsinki.fi.

  6. Lieb-Schultz-Mattis-type filling constraints in the 1651 magnetic space groups

    NASA Astrophysics Data System (ADS)

    Watanabe, Haruki

    2018-04-01

    We present a systematic study of the filling constraints to realize a "trivial" insulator symmetric under magnetic space group M . The filling ν must be an integer multiple of mM to avoid spontaneous symmetry breaking or fractionalization in gapped phases. We improve the value of mM in the literature and prove the tightness of the constraint for the majority of magnetic space groups. The result may shed light on the material search of exotic magnets with fractionalization.

  7. Visuoperception test predicts pathologic diagnosis of Alzheimer disease in corticobasal syndrome

    PubMed Central

    Tierney, Michael; Wassermann, Eric M.; Spina, Salvatore; Oblak, Adrian L.; Ghetti, Bernardino; Grafman, Jordan; Huey, Edward

    2014-01-01

    Objective: To use the Visual Object and Space Perception Battery (VOSP) to distinguish Alzheimer disease (AD) from non-AD pathology in corticobasal syndrome (CBS). Methods: This clinicopathologic study assessed 36 patients with CBS on the VOSP. All were autopsied. The primary dependent variable was a binary pathologic outcome: patients with CBS who had primary pathologic diagnosis of AD (CBS-AD, n = 10) vs patients with CBS without primary pathologic diagnosis of AD (CBS-nonAD, n = 26). We also determined sensitivity and specificity of individual VOSP subtests. Results: Patients with CBS-AD had younger onset (54.5 vs 63.6 years, p = 0.001) and lower memory scores on the Mattis Dementia Rating Scale–2 (16 vs 22 points, p = 0.003). Failure on the VOSP subtests Incomplete Letters (odds ratio [OR] 11.5, p = 0.006), Position Discrimination (OR 10.86, p = 0.008), Number Location (OR 12.27, p = 0.026), and Cube Analysis (OR 45.71 p = 0.0001) had significantly greater odds of CBS-AD than CBS-nonAD. These associations remained when adjusting for total Mattis Dementia Rating score, disease laterality, education, age, and sex. Receiver operating characteristic curves demonstrated significant accuracy for Incomplete Letters and all VOSP spatial subtests, with Cube Analysis performing best (area under the curve 0.91, p = 0.0004). Conclusions: In patients with CBS, failure on specific VOSP subtests is associated with greater odds of having underlying AD. There may be preferential involvement of the dorsal stream in CBS-AD. Classification of evidence: This study provides Class II evidence that some subtests of the VOSP accurately distinguish patients with CBS-AD from those without AD pathology (e.g., Cube Analysis sensitivity 100%, specificity 77%). PMID:24991033

  8. Role of phonons in the metal-insulator phase transition.

    NASA Technical Reports Server (NTRS)

    Langer, W. D.

    1972-01-01

    Review, for the transition series oxides, of the Mattis and Lander model, which is one of electrons interacting with lattice vibrations (electron and phonon interaction). The model displays superconducting, insulating, and metallic phases. Its basic properties evolve from a finite crystallographic distortion associated with a dominant phonon mode and the splitting of the Brillouin zone into two subzones, a property of simple cubic and body centered cubic lattices. The order of the metal-insulator phase transition is examined. The basic model has a second-order phase transition and the effects of additional mechanisms on the model are calculated. The way in which these mechanisms affect the magnetically ordered transition series oxides as described by the Hubbard model is discussed.

  9. Finite quasiparticle lifetime in disordered superconductors.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zemlicka, M.; Neilinger, P.; Trgala, M

    We investigate the complex conductivity of a highly disordered MoC superconducting film with k(F)l approximate to 1, where k(F) is the Fermi wave number and l is the mean free path, derived from experimental transmission characteristics of coplanar waveguide resonators in a wide temperature range below the superconducting transition temperature T-c. We find that the original Mattis-Bardeen model with a finite quasiparticle lifetime, tau, offers a perfect description of the experimentally observed complex conductivity. We show that iota is appreciably reduced by scattering effects. Characteristics of the scattering centers are independently found by scanning tunneling spectroscopy and agree with thosemore » determined from the complex conductivity.« less

  10. Update on Service Management Project

    ScienceCinema

    None

    2018-05-11

    GS and IT Service Management project status meeting - Distribution: Sigurd Lettow, Frederic Hemmer, Thomas Pettersson, David Foster, Matti Tiirakari, GS&IT; Service Providers When and where: Thursday 2nd September at 10:00-11:30 in IFiltration Plant (222-R-001) Dear All, We would like to inform you about progress made on different topics like the Service Catalogue, the new Service Management Tool and the Service Desk. We would also like to present the plan for when we hope to go live and what this will mean for all of you running and providing services today. We will need your active support and help in the coming months to make this happen. GS&IT; Service Management Teams Reinoud Martens, Mats Moller

  11. Learning science through talking science in elementary classroom

    NASA Astrophysics Data System (ADS)

    Tank, Kristina Maruyama; Coffino, Kara

    2014-03-01

    Elementary students in grade two make sense of science ideas and knowledge through their contextual experiences. Mattis Lundin and Britt Jakobson find in their research that early grade students have sophisticated understandings of human anatomy and physiology. In order to understand what students' know about human body and various systems, both drawings and spoken responses provide rich evidence of their understanding of the connections between science drawings and verbal explanations. In this forum contribution, we present several theoretical connections between everyday language and science communication and argue that building communication skills in science are essential. We also discuss how young participants should be valued and supported in research. Finally we discuss the need for multimodal research methods when the research participants are young.

  12. A New First-Principles Calculation of Field-Dependent RF Surface Impedance of BCS Superconductor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiao, Binping; Reece, Charles E.

    2014-02-01

    There is a need to understand the intrinsic limit of radiofrequency (RF) surface impedance that determines the performance of superconducting RF cavities in particle accelerators. Here we present a field-dependent derivation of Mattis-Bardeen theory of the RF surface impedance of BCS superconductors based on the shifted density of states resulting from coherently moving Cooper pairs. Our theoretical prediction of the effective BCS RF surface resistance (Rs) of niobium as a function of peak surface magnetic field amplitude agrees well with recently reported record low loss resonant cavity measurements from JLab and FNAL with carefully, yet differently, prepared niobium material. Themore » surprising reduction in resistance with increasing field is explained to be an intrinsic effect.« less

  13. Geologic map and digital database of the Cougar Buttes 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Powell, R.E.; Matti, J.C.; Cossette, P.M.

    2000-01-01

    The Southern California Areal Mapping Project (SCAMP) of Geologic Division has undertaken regional geologic mapping investigations in the Lucerne Valley area co-sponsored by the Mojave Water Agency and the San Bernardino National Forest. These investigations span the Lucerne Valley basin from the San Bernardino Mountains front northward to the basin axis on the Mojave Desert floor, and from the Rabbit Lake basin east to the Old Woman Springs area. Quadrangles mapped include the Cougar Buttes 7.5' quadrangle, the Lucerne Valley 7.5' quadrangle (Matti and others, in preparation b), the Fawnskin 7.5' quadrangle (Miller and others, 1998), and the Big Bear City 7.5' quadrangle (Matti and others, in preparation a). The Cougar Buttes quadrangle has been mapped previously at scales of 1:62,500 (Dibblee, 1964) and 1:24,000 (Shreve, 1958, 1968; Sadler, 1982a). In line with the goals of the National Cooperative Geologic Mapping Program (NCGMP), our mapping of the Cougar Buttes quadrangle has been directed toward generating a multipurpose digital geologic map database. Guided by the mapping of previous investigators, we have focused on improving our understanding and representation of late Pliocene and Quaternary deposits. In cooperation with the Water Resources Division of the U.S. Geological Survey, we have used our mapping in the Cougar Buttes and Lucerne Valley quadrangles together with well log data to construct cross-sections of the Lucerne Valley basin (R.E. Powell, unpublished data, 1996-1998) and to develop a hydrogeologic framework for the basin. Currently, our mapping in these two quadrangles also is being used as a base for studying soils on various Quaternary landscape surfaces on the San Bernardino piedmont (Eppes and others, 1998). In the Cougar Buttes quadrangle, we have endeavored to represent the surficial geology in a way that provides a base suitable for ecosystem assessment, an effort that has entailed differentiating surficial veneers on piedmont and

  14. Electromagnetic properties of impure superconductors with pair-breaking processes

    NASA Astrophysics Data System (ADS)

    Herman, František; Hlubina, Richard

    2017-07-01

    Recently, a generic model was proposed for the single-particle properties of gapless superconductors with simultaneously present pair-conserving and pair-breaking impurity scatterings (the so-called Dynes superconductors). Here we calculate the optical conductivity of the Dynes superconductors. Our approach is applicable for all disorder strengths from the clean limit up to the dirty limit and for all relative ratios of the two types of scattering; nevertheless, the complexity of our description is equivalent to that of the widely used Mattis-Bardeen theory. We identify two optical fingerprints of the Dynes superconductors: (i) the presence of two absorption edges and (ii) finite absorption at vanishing frequencies even at the lowest temperatures. We demonstrate that the recent anomalous optical data on thin MoN films can be reasonably fitted by our theory.

  15. Quantum annealing for the number-partitioning problem using a tunable spin glass of ions

    PubMed Central

    Graß, Tobias; Raventós, David; Juliá-Díaz, Bruno; Gogolin, Christian; Lewenstein, Maciej

    2016-01-01

    Exploiting quantum properties to outperform classical ways of information processing is an outstanding goal of modern physics. A promising route is quantum simulation, which aims at implementing relevant and computationally hard problems in controllable quantum systems. Here we demonstrate that in a trapped ion setup, with present day technology, it is possible to realize a spin model of the Mattis-type that exhibits spin glass phases. Our method produces the glassy behaviour without the need for any disorder potential, just by controlling the detuning of the spin-phonon coupling. Applying a transverse field, the system can be used to benchmark quantum annealing strategies which aim at reaching the ground state of the spin glass starting from the paramagnetic phase. In the vicinity of a phonon resonance, the problem maps onto number partitioning, and instances which are difficult to address classically can be implemented. PMID:27230802

  16. A 850 GHz SIS receiver employing silicon micro-machining technology

    NASA Technical Reports Server (NTRS)

    Kooi, J. W.; Pety, J.; Schaffer, P. L.; Phillips, T. G.; Bumble, B.; LeDuc, H. G.; Walker, C. K.

    1996-01-01

    A 850 GHz superconductor-insulator-superconductor (SIS) heterodyne receiver which uses a radiofrequency tuned niobium tunnel junction fabricated on a 1 micron thick silicon nitrate membrane, is reported. From video and heterodyne measurements, it was calculated that the niobium film loss in the radiofrequency matching network is about 6.8 dB at 822 GHz. These results are approximately a factor of two higher than the theoretical loss predicted by the Mattis-Bardeen theory in the extreme anomalous limit. The junction design and the receiver configuration are described, including the mixer block, the membrane construction and the cooled optics. The performance tests using a Fourier transform spectrometer to measure the response of the radiofrequency matching network, and the SIS simulations of the receiver response to cold and hot loads, the infrared noise contribution and the overall mixer conversion efficiency, are reported. It is concluded that the receiver response is limited by the absorption loss in the radiofrequency matching network.

  17. Exploring the performance of thin-film superconducting multilayers as kinetic inductance detectors for low-frequency detection

    NASA Astrophysics Data System (ADS)

    Zhao, Songyuan; Goldie, D. J.; Withington, S.; Thomas, C. N.

    2018-01-01

    We have solved numerically the diffusive Usadel equations that describe the spatially varying superconducting proximity effect in Ti-Al thin-film bi- and trilayers with thickness values that are suitable for kinetic inductance detectors (KIDs) to operate as photon detectors with detection thresholds in the frequency range of 50-90 GHz. Using Nam’s extension of the Mattis-Bardeen calculation of the superconductor complex conductivity, we show how to calculate the surface impedance for the spatially varying case, and hence the surface impedance quality factor. In addition, we calculate energy-and spatially-averaged quasiparticle lifetimes at temperatures well-below the transition temperature and compare to calculation in Al. Our results for the pair-breaking threshold demonstrate differences between bilayers and trilayers with the same total film thicknesses. We also predict high quality factors and long multilayer-averaged quasiparticle recombination times compared to thin-film Al. Our calculations give a route for designing KIDs to operate in this scientifically-important frequency regime.

  18. Age and paleoenvironment of the imperial formation near San Gorgonio Pass, Southern California

    USGS Publications Warehouse

    McDougall, K.; Poore, R.Z.; Matti, J.

    1999-01-01

    Microfossiliferous marine sediments of the Imperial Formation exposed in the Whitewater and Cabazon areas, near San Gorgonio Pass, southern California, are late Miocene in age and were deposited at intertidal to outer neritic depths, and possibly upper bathyal depths. A late Miocene age of 7.4 to >6.04 Ma is based on the ranges of age-diagnostic benthic foraminifers (Cassidulina delicata and Uvigerina peregrina), planktic foraminifers (Globigerinoides obliquus, G. extremus, and Globigerina nepenthes; zones N17-N19), and calcareous nannoplankton (Discoaster brouweri, D. aff. D. surculus, Reticulofenestra pseudoumbilicata, Sphenolithus abies, and S. neoabies; zones CN9a-CN11) coupled with published K/Ar dates from the underlying Coachella Formation (10.1 ?? 1.2 Ma; Peterson, 1975) and overlying Painted Hill Formation (6.04 ?? 0.18 and 5.94 ?? 0.18 Ma; J. L. Morton in Matti and others, 1985 and Matti and Morton, 1993). Paleoecologic considerations (sea-level fluctuations and paleotemperature) restrict the age of the Imperial Formation to 6.5 through 6.3 Ma. Benthic foraminiferal assemblages indicate that the Imperial Formation in the Whitewater and Cabazon sections accumulated at inner neritic to outer neritic (0-152 m) and possibly upper bathyal (152-244 m) depths. Shallowing to inner neritic depths occurred as the upper part of the section was deposited. This sea-level fluctuation corresponds to a global highstand at 6.3 Ma (Haq and others, 1987). Planktic foraminifers suggest an increase in surface-water temperatures upsection. A similar increase in paleotemperatures is interpreted for the North Pacific from 6.5 to 6.3 Ma (warm interval W10 of Barron and Keller, 1983). Environmental contrasts between the Whitewater and Cabazon sections of the Imperial Formation provide evidence for right-lateral displacements on the Banning fault, a late Miocene strand of the San Andreas fault system. The Cabazon section lies south of the Banning fault, and has been displaced west

  19. Hadoop-BAM: directly manipulating next generation sequencing data in the cloud

    PubMed Central

    Niemenmaa, Matti; Kallio, Aleksi; Schumacher, André; Klemelä, Petri; Korpelainen, Eija; Heljanko, Keijo

    2012-01-01

    Summary: Hadoop-BAM is a novel library for the scalable manipulation of aligned next-generation sequencing data in the Hadoop distributed computing framework. It acts as an integration layer between analysis applications and BAM files that are processed using Hadoop. Hadoop-BAM solves the issues related to BAM data access by presenting a convenient API for implementing map and reduce functions that can directly operate on BAM records. It builds on top of the Picard SAM JDK, so tools that rely on the Picard API are expected to be easily convertible to support large-scale distributed processing. In this article we demonstrate the use of Hadoop-BAM by building a coverage summarizing tool for the Chipster genome browser. Our results show that Hadoop offers good scalability, and one should avoid moving data in and out of Hadoop between analysis steps. Availability: Available under the open-source MIT license at http://sourceforge.net/projects/hadoop-bam/ Contact: matti.niemenmaa@aalto.fi Supplementary information: Supplementary material is available at Bioinformatics online. PMID:22302568

  20. Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI.

    PubMed Central

    Deweer, B; Lehéricy, S; Pillon, B; Baulac, M; Chiras, J; Marsault, C; Agid, Y; Dubois, B

    1995-01-01

    Magnetic resonance based volumetric measures of hippocampal formation, amygdala (A), caudate nucleus (CN), normalised for total intracranial volume (TIV), were analysed in relation to measures of cognitive deterioration and specific features of memory functions in 18 patients with probable Alzheimer's disease. Neuropsychological examination included the mini mental state examination (MMSE), the Mattis dementia rating scale (DRS), tests of executive functions, assessment of language abilities and praxis, the Wechsler memory scale (WMS), the California verbal learning test (CVLT) and the Grober and Buschke test. The volume of the hippocampal formation (HF/TIV) was correlated with specific memory variables: memory quotient and paired associates of the WMS; intrusions and discriminability at recognition for the Grober and Buschke test. By contrast, except for intrusions, no correlations were found between memory variables and the volume of amygdala (A/TIV). No correlations were found between the volume of caudate nuclei (CN/TIV) and any neuropsychological score. The volume of the hippocampal formation was therefore selectively related to quantitative and qualitative aspects of memory performance in patients with probable Alzheimer's disease. Images PMID:7745409

  1. Filling constraints for spin-orbit coupled insulators in symmorphic and nonsymmorphic crystals

    PubMed Central

    Watanabe, Haruki; Po, Hoi Chun; Vishwanath, Ashvin; Zaletel, Michael

    2015-01-01

    We determine conditions on the filling of electrons in a crystalline lattice to obtain the equivalent of a band insulator—a gapped insulator with neither symmetry breaking nor fractionalized excitations. We allow for strong interactions, which precludes a free particle description. Previous approaches that extend the Lieb–Schultz–Mattis argument invoked spin conservation in an essential way and cannot be applied to the physically interesting case of spin-orbit coupled systems. Here we introduce two approaches: The first one is an entanglement-based scheme, and the second one studies the system on an appropriate flat “Bieberbach” manifold to obtain the filling conditions for all 230 space groups. These approaches assume only time reversal rather than spin rotation invariance. The results depend crucially on whether the crystal symmetry is symmorphic. Our results clarify when one may infer the existence of an exotic ground state based on the absence of order, and we point out applications to experimentally realized materials. Extensions to new situations involving purely spin models are also mentioned. PMID:26604304

  2. The Mattis Way of War: An Examination of Operational Art in Task Force 58 and 1st Marine Division

    DTIC Science & Technology

    2014-12-12

    Research Questions Did his innovations work? Are they worthy of repeating? Did his style evolve as he increased in responsibility? What role did current...staff was born both out of necessity, lack of physical space, and personal style . Efficiencies gained from a small staff generate speed in orders...

  3. The isotopic composition of ore lead of the Creede mining district and vicinity, San Juan Mountains, Colorado: Text of a talk presented at the San Juan Mountains symposium to honor Thomas A. Steven; Rocky Mountain Section meeting of the Geological Society of America, May 2, 1987, Boulder, Colorado

    USGS Publications Warehouse

    Foley, N.K.; Barton, P.B.; Bethke, P.M.; Doe, B.R.

    1988-01-01

    Recent work allows us to extend the results of Doe et al. and to consider alternative processes to explain the widespread homogeneity and radiogenic nature of the ore lead: 1) David Matty (pers. commun., 1986) has shown that some minor volcanic units in the area have unusually radiogneic lead values; magmas comparable in composition to the units are a possible, though improbable, source of the ore lead. 2) The uniformity of the isotopic values of galenas may have resulted from homogenization during an extensive potassium-metasomatic event that predated the ores; this possibility is being tested in an on-going study of feldspars from metasomatized and unmetasomatized rocks. 3) Recent regional studies suggest the possibility of a prevolcanic, NNW-trending graben system filled by clastic sediments derived from the Precambrian basement, a process that would have an homogenizing effect on the lead isotopes. This interpretation implies importation, deep within the Creede hydrologic system, of fluids from remote sources. These alternatives show that the Pbisotope systematics may have a profound impact on the interpretation of the Creede hydrothermal system, and that further study is warranted.

  4. Unprecedented quality factors at accelerating gradients up to 45 MVm-1 in niobium superconducting resonators via low temperature nitrogen infusion

    NASA Astrophysics Data System (ADS)

    Grassellino, A.; Romanenko, A.; Trenikhina, Y.; Checchin, M.; Martinello, M.; Melnychuk, O. S.; Chandrasekaran, S.; Sergatskov, D. A.; Posen, S.; Crawford, A. C.; Aderhold, S.; Bice, D.

    2017-09-01

    We report the finding of new surface treatments that permits one to manipulate the niobium resonator nitrogen content in the first few nanometers in a controlled way, and the resonator fundamental Mattis-Bardeen surface resistance and residual resistance accordingly. In particular, we find surface ‘infusion’ conditions that systematically (a) increase the quality factor of these 1.3 GHz superconducting radio frequency (SRF) bulk niobium resonators, up to very high gradients; (b) increase the achievable accelerating gradient of the cavity compared to its own baseline with state-of-the-art surface processing. Cavities subject to the new surface process have more than two times the state-of-the-art Q at 2 K for accelerating fields >35 MVm-1. Moreover, very high accelerating gradients ˜45 MVm-1 are repeatedly reached, which correspond to peak magnetic surface fields of 190 mT, among the highest measured for bulk niobium cavities. These findings open the opportunity to tailor the surface impurity content distribution to maximize performance in Q and gradients, and have therefore very important implications on future performance and cost of SRF based accelerators. They also help deepen the understanding of the physics of the RF niobium cavity surface.

  5. Anomalous phonon behavior in superconducting CaKFe 4 As 4 : An optical study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Run; Dai, Yaomin; Xu, Bing

    Here, the temperature dependence of ab-plane optical conductivity of CaKFe 4As 4 has been measured below and above its superconducting transition temperature T c≃35.5 K. In the normal state, analysis with the two-Drude model reveals a T-linear scattering rate for the coherent response, which suggests strong spin-fluctuation scattering. Below the superconducting transition, the optical conductivity below 120 cm –1 vanishes, indicating nodeless gap(s). The Mattis-Bardeen fitting in the superconducting state gives two gaps of Δ 1 ≃ 9 meV and Δ 2 ≃ 14 meV, in good agreement with recent angle-resolved photoemission spectroscopy (ARPES) results. In addition, around 255 cmmore » –1, we observe two different infrared-active Fe-As modes with obvious asymmetric lineshape, originating from strong coupling between lattice vibrations and spin or charge excitations. Considering a moderate Hund's rule coupling determined from spectral weight analysis, we propose that the strong fluctuations induced by the coupling between itinerant carriers and local moments may affect the phonon mode, and the electron-phonon coupling through the spin channel is likely to play an important role in the unconventional pairing in iron-based superconductors.« less

  6. Unprecedented quality factors at accelerating gradients up to 45 MVm -1 in niobium superconducting resonators via low temperature nitrogen infusion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grassellino, A.; Romanenko, A.; Trenikhina, Y.

    We report the finding of new surface treatments that permit to manipulate the niobium resonator nitrogen content in the first few nanometers in a controlled way, and the resonator fundamental Mattis-Bardeen surface resistance and residual resistance accordingly. In particular, we find surface infusion conditions that systematically a) increase the quality factor of these 1.3 GHz superconducting radio frequency (SRF) bulk niobium resonators, up to very high gradients; b) increase the achievable accelerating gradient of the cavity compared to its own baseline with state-of-the-art surface processing. Cavities subject to the new surface process have larger than two times the state ofmore » the art Q at 2K for accelerating fields > 35 MV/m. Moreover, very high accelerating gradients ~ 45 MV/m are repeatedly reached, which correspond to peak magnetic surface fields of 190 mT, among the highest measured for bulk niobium cavities. These findings open the opportunity to tailor the surface impurity content distribution to maximize performance in Q and gradients, and have therefore very important implications on future performance and cost of SRF based accelerators. They also help deepen the understanding of the physics of the RF niobium cavity surface.« less

  7. Anomalous phonon behavior in superconducting CaKFe 4 As 4 : An optical study

    DOE PAGES

    Yang, Run; Dai, Yaomin; Xu, Bing; ...

    2017-02-08

    Here, the temperature dependence of ab-plane optical conductivity of CaKFe 4As 4 has been measured below and above its superconducting transition temperature T c≃35.5 K. In the normal state, analysis with the two-Drude model reveals a T-linear scattering rate for the coherent response, which suggests strong spin-fluctuation scattering. Below the superconducting transition, the optical conductivity below 120 cm –1 vanishes, indicating nodeless gap(s). The Mattis-Bardeen fitting in the superconducting state gives two gaps of Δ 1 ≃ 9 meV and Δ 2 ≃ 14 meV, in good agreement with recent angle-resolved photoemission spectroscopy (ARPES) results. In addition, around 255 cmmore » –1, we observe two different infrared-active Fe-As modes with obvious asymmetric lineshape, originating from strong coupling between lattice vibrations and spin or charge excitations. Considering a moderate Hund's rule coupling determined from spectral weight analysis, we propose that the strong fluctuations induced by the coupling between itinerant carriers and local moments may affect the phonon mode, and the electron-phonon coupling through the spin channel is likely to play an important role in the unconventional pairing in iron-based superconductors.« less

  8. Temperature dependence of the superconducting energy gaps in Ca9.35La0.65(Pt3As8)(Fe2As2)5 single crystal.

    PubMed

    Seo, Yu-Il; Choi, Woo-Jae; Ahmad, D; Kimura, Shin-Ichi; Kwon, Yong Seung

    2018-06-05

    We measured the optical reflectivity R(ω) for an underdoped (Ca 0.935 La 0.065 ) 10 (Pt 3 As 8 )(Fe 2 As 2 ) 5 single crystal and obtained the optical conductivity [Formula: see text] using the K-K transformation. The normal state [Formula: see text] at 30 K is well fitted by a Drude-Lorentz model with two Drude components (ω p1  = 1446 cm -1 and ω p2  = 6322 cm -1 ) and seven Lorentz components. Relative reflectometry was used to accurately determine the temperature dependence of the superconducting gap at various temperatures below T c . The results clearly show the opening of a superconducting gap with a weaker second gap structure; the magnitudes for the gaps are estimated from the generalized Mattis-Bardeen model to be Δ 1  = 30 and Δ 2  = 50 cm -1 , respectively, at T = 8 K, which both decrease with increasing temperature. The temperature dependence of the gaps was not consistent with one-band BCS theory but was well described by a two-band (hence, two gap) BCS model with interband interactions. The temperature dependence of the superfluid density is flat at low temperatures, indicating an s-wave full-gap superconducting state.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morin, R

    The Medical Physics community lost one of its prominent leaders in April, 2013 with the passing of Donald D. Tolbert, PhD. He received his Doctorate at the University of Kansas followed by post Doctoral training at Florida State University and the University of Wisconsin. He was Chief of Radiation Therapy Medical Physics at the University of Wisconsin Hospital for 7 years before relocating to Honolulu Hawaii, where he founded the consulting group Mid-Pacific Medical Physics. Don was a leader in both the AAPM and the ACR, chairing the Professional Council and the Commission on Medical Physics. He was active onmore » the AAPM Board of Directors and a member of the ACR Board of Chancellors. Dr. Tolbert's approach to the difficult problems of the times was admired and respected by colleagues in Medical Physics, Radiation Oncology, and Diagnostic Radiology. He always rose above the heated political rhetoric and led the discussion to higher ground. His wisdom was continually sought to solve complicated problems. Following retirement, he returned to homes in Kansas and Colorado, devoting his time to writing about coping with diabetes and providing support for Seniors in Beloit Kansas. Don is survived by his wife, Mattie, his 3 children and 5 grandchildren. He will be greatly missed.« less

  10. Spin fluctations and heavy fermions in the Kondo lattice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Khaliullin, G.G.

    1994-09-01

    This paper studies the spectrum of the spin and electronic excitations of the Kondo lattice at low temperatures. To avoid unphysical states, the Mattis {open_quotes}drone{close_quotes}-fermion representation for localized spins is employed. First, the known Fermi liquid properties of a single impurity are examined. The behavior of the correlator between a localized spin and the electron spin density at large distances shows that the effective interaction between electrons on the Fermi level and low-energy localized spin fluctuations scales as {rho}{sup {minus}1}, where {rho} is the band-state density. This fact is developed into a renormalization of the band spectrum in a periodicmore » lattice. If the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction between localized spins is much smaller than the Kondo fluctuation frequency {omega}{sub k}, the temperature of the crossover to the single-parameter Fermi liquid mode is determined by {omega}{sub k}. When the RKKY interaction becomes of order {omega}{sub k}, there is a new scale {omega}{sub sf}, the energy of the (antiferromagnetic) paramagnon mode, with {omega}{sub sf}{much_lt}{omega}{sub k}. Here the coherent Fermi liquid regime is realized only below a temperature T{sub coh} of order {omega}{sub sf}, while above T{sub coh} quasiparticle damping exhibits a linear temperature dependence. Finally, the nuclear-spin relaxation rate is calculated. 42 refs.« less

  11. Benton Judgment of Line Orientation (JoLO) Test: A Brief and Useful Measure for Assessing Visuospatial Abilities in Manifest, but not Premanifest, Huntington's Disease.

    PubMed

    Corey-Bloom, Jody; Gluhm, Shea; Herndon, Andrew; Haque, Ameera S; Park, Sungmee; Gilbert, Paul E

    2016-01-01

    Visuospatial deficits have been described in Huntington's disease (HD); however, the extent of these deficits remains unclear. The Benton Judgment of Line Orientation (JoLO) Test, commonly used to assess visuospatial ability, requires minimal motor involvement. It has demonstrated sensitivity to visuospatial deficits in Parkinson's disease; however, few studies have examined performance on this test in HD. The objective of the current study was to assess visuospatial ability in premanifest and manifest HD using the JoLO. A global cognitive measure, the Mattis Dementia Rating Scale (DRS), was used to stratify manifest HD patients as mild (DRS ≥129) vs. moderate-severe (DRS ≤128). Fifty mild, 42 moderate-severe, and 30 premanifest HD subjects, as well as 35 matched controls, were administered the JoLO. HD Burden of Pathology (BOP) scores were used as a measure of disease severity. Results revealed that the total manifest HD sample (p <  0.001), in addition to the mild (p = 0.028), and moderate-severe (p <  0.001), but not premanifest, HD subjects scored significantly lower on the JoLO compared to normal controls. Our results suggest that the JoLO is useful for detecting visuospatial deficits across various stages of manifest HD. However, any visuospatial impairment that might be present during the premanifest stage of HD was not detected using the JoLO in the present sample.

  12. Olfactory Deficit Detected by fMRI in Early Alzheimer’s Disease

    PubMed Central

    Wang, Jianli; Eslinger, Paul J.; Doty, Richard L.; Zimmerman, Erin K.; Grunfeld, Robert; Sun, Xiaoyu; Connor, James R.; Price, Joseph L.; Smith, Michael B.; Yang, Qing X.

    2012-01-01

    Alzheimer’s disease (AD) is accompanied by smell dysfunction, as measured by psychophysical tests. Currently it is unknown whether AD-related alterations in central olfactory system neural activity, as measured by functional magnetic resonance imaging (fMRI), are detectable beyond those observed in healthy elderly. Moreover, it is not known whether such changes are correlated with indices of odor perception and dementia. To investigate these issues, twelve early stage AD patients and thirteen non-demented controls underwent fMRI while being exposed to each of three concentrations of lavender oil odorant. All participants were administered the University of Pennsylvania Smell Identification Test (UPSIT), the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale-2 (DRS-2), and the Clinical Dementia Rating Scale (CDR). The Blood oxygen level-dependent (BOLD) signal at primary olfactory cortex (POC) was weaker in AD than in HC subjects. At the lowest odorant concentration, the BOLD signals within POC, hippocampus, and insula were significantly correlated with UPSIT, MMSE, DRS-2, and CDR scores. The BOLD signal intensity and activation volume within the POC increased significantly as a function of odorant concentration in the AD group, but not in the control group. These findings demonstrate that olfactory fMRI is sensitive to the AD-related olfactory and functional cognitive decline. PMID:20709038

  13. metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.

    PubMed

    Cichonska, Anna; Rousu, Juho; Marttinen, Pekka; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Raitakari, Olli T; Järvelin, Marjo-Riitta; Salomaa, Veikko; Ala-Korpela, Mika; Ripatti, Samuli; Pirinen, Matti

    2016-07-01

    A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and restricted availability of individual-level genotype-phenotype data across the cohorts limit conducting multivariate tests. We introduce metaCCA, a computational framework for summary statistics-based analysis of a single or multiple studies that allows multivariate representation of both genotype and phenotype. It extends the statistical technique of canonical correlation analysis to the setting where original individual-level records are not available, and employs a covariance shrinkage algorithm to achieve robustness.Multivariate meta-analysis of two Finnish studies of nuclear magnetic resonance metabolomics by metaCCA, using standard univariate output from the program SNPTEST, shows an excellent agreement with the pooled individual-level analysis of original data. Motivated by strong multivariate signals in the lipid genes tested, we envision that multivariate association testing using metaCCA has a great potential to provide novel insights from already published summary statistics from high-throughput phenotyping technologies. Code is available at https://github.com/aalto-ics-kepaco anna.cichonska@helsinki.fi or matti.pirinen@helsinki.fi Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

  14. Summary Report of Cable Aging and Performance Data for Fiscal Year 2014.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Celina, Mathias C.; Celina, Mathias C.; Redline, Erica Marie

    2014-09-01

    As part of the Light Water Reactor Sustainability Program, science - based engineering approaches were employed to address cable degradation behavior under a range of exposure environments. Experiments were conducted with the goal to provide best guidance for aged material states, remaining life and expected performance under specific conditions for a range of cable materials. Generic engineering tests , which focus on rapid accelerated aging and tensile elongation , were combined with complementar y methods from polymer degradation science. Sandia's approach, building on previous years' efforts, enabled the generation of some of the necessary data supporting the development of improvedmore » lifetime predictions models, which incorporate known material b ehaviors and feedback from field - returned 'aged' cable materials. Oxidation rate measurements have provided access to material behavior under low dose rate thermal conditions, where slow degradation is not apparent in mechanical property changes. Such da ta have shown aging kinetics consistent with established radiati on - thermal degradation models. ACKNOWLEDGEMENTS We gratefully acknowledge ongoing technical support at the LICA facility and extensive sample handling provided by Maryla Wasiolek and Don Hans on. Sam Durbin and Patrick Mattie are recognized for valuable guidance throughout the year and assistance in the preparation of the final report. Doug Brunson is appreciated for sample analysis, compilation and plotting of experimental data.« less

  15. Executive functions in mild cognitive impairment: emergence and breakdown of neural plasticity.

    PubMed

    Clément, Francis; Gauthier, Serge; Belleville, Sylvie

    2013-05-01

    Our goal was to test the effect of disease severity on the brain activation associated with two executive processes: manipulation and divided attention. This was achieved by administrating a manipulation task and a divided attention task using functional magnetic resonance imaging to 24 individuals with mild cognitive impairment (MCI) and 14 healthy controls matched for age, sex and education. The Mattis Dementia Rating Scale was used to divide persons with MCI into those with better and worse cognitive performances. Both tasks were associated with more brain activation in the MCI group with higher cognition than in healthy controls, particularly in the left frontal areas. Correlational analyses indicated that greater activation in a frontostriatal network hyperactivated by the higher-cognition group was related with better task performance, suggesting that these activations may support functional reorganization of a compensatory nature. By contrast, the lower-cognition group failed to show greater cerebral hyperactivation than controls during the divided attention task and, during the manipulation task, and showed less brain activation than controls in the left ventrolateral cortex, a region commonly hypoactivated in patients with Alzheimer's disease. These findings indicate that, during the early phase of MCI, executive functioning benefits from neural reorganization, but that a breakdown of this brain plasticity characterizes the late stages of MCI. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. The effect of cognitive impairment on mental healthcare costs for individuals with severe psychiatric illness.

    PubMed

    Mackin, R Scott; Delucchi, Kevin L; Bennett, Robert W; Areán, Patricia A

    2011-02-01

    This study was conducted to determine the effect of cognitive impairment (CI) on mental healthcare costs for older low-income adults with severe psychiatric illness. Data were collected from 62 ethnically diverse low-income older adults with severe psychiatric illness who were participating in day programming at a large community mental health center. CI was diagnosed by a neuropsychologist utilizing the Mattis Dementia Rating Scale-Second Edition and structured ratings of functional impairment (Clinical Dementia Rating Scale). Mental healthcare costs for 6, 12, and 24-month intervals before cognitive assessments were obtained for each participant. Substance abuse history was evaluated utilizing a structured questionnaire, depression symptom severity was assessed utilizing the Hamilton Depression Rating Scale, and psychiatric diagnoses were obtained through medical chart abstraction. CI was exhibited by 61% of participants and was associated with significantly increased mental healthcare costs during 6, 12, and 24-month intervals. Results of a regression analysis indicated that ethnicity and CI were both significant predictors of log transformed mental healthcare costs over 24 months with CI accounting for 13% of the variance in cost data. CI is a significant factor associated with increased mental healthcare costs in patients with severe psychiatric illness. Identifying targeted interventions to accommodate CI may lead to improving treatment outcomes and reducing the burden of mental healthcare costs for individuals with severe psychiatric illness.

  17. Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia.

    PubMed

    Boutoleau-Bretonnière, Claire; Lebouvier, Thibaud; Volteau, Christelle; Jaulin, Philippe; Lacomblez, Lucette; Damier, Philippe; Thomas-Anterion, Catherine; Vercelletto, Martine

    2012-01-01

    The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden. Copyright © 2012 S. Karger AG, Basel.

  18. metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

    PubMed Central

    Cichonska, Anna; Rousu, Juho; Marttinen, Pekka; Kangas, Antti J.; Soininen, Pasi; Lehtimäki, Terho; Raitakari, Olli T.; Järvelin, Marjo-Riitta; Salomaa, Veikko; Ala-Korpela, Mika; Ripatti, Samuli; Pirinen, Matti

    2016-01-01

    Motivation: A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and restricted availability of individual-level genotype-phenotype data across the cohorts limit conducting multivariate tests. Results: We introduce metaCCA, a computational framework for summary statistics-based analysis of a single or multiple studies that allows multivariate representation of both genotype and phenotype. It extends the statistical technique of canonical correlation analysis to the setting where original individual-level records are not available, and employs a covariance shrinkage algorithm to achieve robustness. Multivariate meta-analysis of two Finnish studies of nuclear magnetic resonance metabolomics by metaCCA, using standard univariate output from the program SNPTEST, shows an excellent agreement with the pooled individual-level analysis of original data. Motivated by strong multivariate signals in the lipid genes tested, we envision that multivariate association testing using metaCCA has a great potential to provide novel insights from already published summary statistics from high-throughput phenotyping technologies. Availability and implementation: Code is available at https://github.com/aalto-ics-kepaco Contacts: anna.cichonska@helsinki.fi or matti.pirinen@helsinki.fi Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153689

  19. Quantum Spin Liquids and Fractionalization

    NASA Astrophysics Data System (ADS)

    Misguich, Grégoire

    This chapter discusses quantum antiferromagnets which do not break any symmetries at zero temperature - also called "spin liquids" - and focuses on lattice spin models with Heisenberg-like (i.e. SU(2)-symmetric) interactions in dimensions larger than one. We begin by discussing the Lieb-Schultz-Mattis theorem and its recent extension to D > 1 by Hastings (2004), which establishes an important distinction between spin liquids with an integer and with a half-integer spin per unit cell. Spin liquids of the first kind, "band insulators", can often be understood by elementary means, whereas the latter, "Mott insulators", are more complex (featuring "topological order") and support spin-1/2 excitations (spinons). The fermionic formalism (Affleck and Marston, 1988) is described and the effect of fluctuations about mean-field solutions, such as the possible creation of instabilities, is discussed in a qualitative way. In particular, we explain the emergence of gauge modes and their relation to fractionalization. The concept of the projective symmetry group (X.-G. Wen, 2002) is introduced, with the aid of some examples. Finally, we present the phenomenology of (gapped) short-ranged resonating-valence-bond spin liquids, and make contact with the fermionic approach by discussing their description in terms of a fluctuating Z 2 gauge field. Some recent references are given to other types of spin liquid, including gapless ones.

  20. Cognitive decline and survival in Alzheimer's disease according to education level.

    PubMed

    Bruandet, A; Richard, F; Bombois, S; Maurage, C A; Masse, I; Amouyel, P; Pasquier, F

    2008-01-01

    We tested the hypothesis that a higher education level is associated with faster cognitive decline and lower survival in a cohort of 670 Alzheimer's disease patients, followed for 3.5 years at the Lille-Bailleul memory centre. The patients were categorized in 3 groups according to educational levels: low (12 years). Cognitive function was measured with the Mini Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (DRS). Survival was analyzed with a Cox model. Analyses were adjusted for age, sex, cholinesterase inhibitor treatment, diabetes, hypertension, visible vascular lesions on MRI, baseline DRS and MMSE. The adjusted mixed random model showed that MMSE declined faster for patients with high and intermediate educational levels compared with those with a low educational level (p < 0.0001). The mean annually adjusted DRS decline was highest for the groups with the most education (p = 0.05). The mortality risk was not higher in the better-educated groups (high vs. low: RR = 0.84; 95% CI = 0.35-1.99, intermediate vs. low: RR = 0.82; 95% CI = 0.41-1.63). In our cohort, highly educated patients had a faster cognitive decline than less educated patients but similar mortality rates. Our findings support the cognitive reserve hypothesis. (c) 2007 S. Karger AG, Basel.

  1. Effects of Insulin and Octreotide on Memory and Growth Hormone in Alzheimer's Disease

    PubMed Central

    Watson, G. Stennis; Baker, Laura D.; Cholerton, Brenna A.; Rhoads, Kristoffer W.; Merriam, George R.; Schellenberg, Gerard D.; Asthana, PhD;Sanjay; Cherrier, Monique; Craft, Suzanne

    2009-01-01

    Both insulin alone and the somatostatin analogue octreotide alone facilitate memory in patients with Alzheimer's disease (AD). Since octreotide inhibits endogenous insulin secretion, the cognitive effects of insulin and octreotide may not be independent. This study tested the individual and interactive effects of insulin and octreotide on memory and plasma growth hormone (GH) levels in older adults. Participants were 16 memory-impaired (AD=7, amnestic mild cognitive impairment=9; apolipoprotein E [APOE] ε4- [no ε4 alleles]=9, ε4+ [1-2 ε4 alleles]=7) and 19 cognitively-intact older adults (APOE ε4-=17, ε4+=1). On separate days, fasting participants received counterbalanced infusions of (1) insulin (1 mU·kg-1·min-1) and dextrose to maintain euglycemia, (2) octreotide (150 μg/h), (3) insulin, dextrose, and octreotide, or (4) saline. Story recall was the principal endpoint. Insulin alone facilitated delayed recall for ε4-patients, relative to ε4+ patients (P=0.0012). Furthermore, ε4- patients with higher Mattis Dementia Rating Scale (DRS) scores had greater octreotide-induced memory facilitation (P=0.0298). For healthy adults, octreotide facilitated memory (P=0.0122). Unexpectedly, hyperinsulinemia with euglycemia increased GH levels in healthy controls (P=0.0299). Thus, insulin and octreotide appear to regulate memory in older adults. APOE ε4 genotype modulates responses to insulin and octreotide. Finally, insulin may regulate GH levels during euglycemia. PMID:19625744

  2. Is ApoE ε4 Associated with Cognitive Functioning in African Americans Diagnosed with Alzheimer Disease? An Exploratory Study

    PubMed Central

    Mount, David L.; Ashley, Angela V.; Lah, James J.; Levey, Allan I.; Goldstein, Felicia C.

    2015-01-01

    Objective The effect of the apolipoprotein ε4 allele (ApoE ε4) on cognitive performance in patients with probable Alzheimer disease (AD) has been studied in primarily Caucasian samples. The aim of this exploratory study was to examine whether the presence of ApoE ε4 is associated with cognitive performance in African American AD patients. Methods A cross-sectional, retrospective design was used to address the study objective. Data were extracted from the records of 65 African American patients who participated in the National Institutes of Health-National Institute on Aging (NIH-NIA) Emory University Alzheimer Disease Center Registry. Inclusion criteria were a clinical diagnosis of probable AD, cognitive testing using the Mattis Dementia Rating Scale and the Consortium to Establish a Registry for Alzheimer Disease (CERAD) neuropsychological battery, and ApoE genotyping. Results Seventy percent of the patients were ApoE ε4 positive. Multiple regression analyses indicated that ApoE ε4 was significantly associated with poorer design copying (CERAD Constructional Praxis subtest), but other significant relationships were not observed between positive ε4 status and cognitive performance. Conclusions These preliminary findings suggest that the ApoE ε4 allele is not strongly associated with a particular pattern of cognitive functioning in African Americans once they are diagnosed with AD. However, these findings require replication in a large prospectively recruited and population-based sample of African American AD patients before firm conclusions can be reached. PMID:19668025

  3. Some physical approaches to protein folding

    NASA Astrophysics Data System (ADS)

    Bascle, J.; Garel, T.; Orland, H.

    1993-02-01

    To understand how a protein folds is a problem which has important biological implications. In this article, we would like to present a physics-oriented point of view, which is twofold. First of all, we introduce simple statistical mechanics models which display, in the thermodynamic limit, folding and related transitions. These models can be divided into (i) crude spin glass-like models (with their Mattis analogs), where one may look for possible correlations between the chain self-interactions and the folded structure, (ii) glass-like models, where one emphasizes the geometrical competition between one- or two-dimensional local order (mimicking α helix or β sheet structures), and the requirement of global compactness. Both models are too simple to predict the spatial organization of a realistic protein, but are useful for the physicist and should have some feedback in other glassy systems (glasses, collapsed polymers .... ). These remarks lead us to the second physical approach, namely a new Monte-Carlo method, where one grows the protein atom-by-atom (or residue-by-residue), using a standard form (CHARMM .... ) for the total energy. A detailed comparison with other Monte-Carlo schemes, or Molecular Dynamics calculations, is then possible; we will sketch such a comparison for poly-alanines. Our twofold approach illustrates some of the difficulties one encounters in the protein folding problem, in particular those associated with the existence of a large number of metastable states. Le repliement des protéines est un problème qui a de nombreuses implications biologiques. Dans cet article, nous présentons, de deux façons différentes, un point de vue de physicien. Nous introduisons tout d'abord des modèles simples de mécanique statistique qui exhibent, à la limite thermodynamique, des transitions de repliement. Ces modèles peuvent être divisés en (i) verres de spin (éventuellement à la Mattis), où l'on peut chercher des corrélations entre les

  4. Twisting Anderson pseudospins with light: Quench dynamics in terahertz-pumped BCS superconductors

    NASA Astrophysics Data System (ADS)

    Chou, Yang-Zhi; Liao, Yunxiang; Foster, Matthew S.

    2017-03-01

    We study the preparation (pump) and the detection (probe) of far-from-equilibrium BCS superconductor dynamics in THz pump-probe experiments. In a recent experiment [R. Matsunaga, Y. I. Hamada, K. Makise, Y. Uzawa, H. Terai, Z. Wang, and R. Shimano, Phys. Rev. Lett. 111, 057002 (2013), 10.1103/PhysRevLett.111.057002], an intense monocycle THz pulse with center frequency ω ≃Δ was injected into a superconductor with BCS gap Δ ; the subsequent postpump evolution was detected via the optical conductivity. It was argued that nonlinear coupling of the pump to the Anderson pseudospins of the superconductor induces coherent dynamics of the Higgs (amplitude) mode Δ (t ) . We validate this picture in a two-dimensional BCS model with a combination of exact numerics and the Lax reduction method, and we compute the nonequilibrium phase diagram as a function of the pump intensity. The main effect of the pump is to scramble the orientations of Anderson pseudospins along the Fermi surface by twisting them in the x y plane. We show that more intense pump pulses can induce a far-from-equilibrium phase of gapless superconductivity ("phase I"), originally predicted in the context of interaction quenches in ultracold atoms. We show that the THz pump method can reach phase I at much lower energy densities than an interaction quench, and we demonstrate that Lax reduction (tied to the integrability of the BCS Hamiltonian) provides a general quantitative tool for computing coherent BCS dynamics. We also calculate the Mattis-Bardeen optical conductivity for the nonequilibrium states discussed here.

  5. Executive Function and Remission of Geriatric Depression: The Role of Semantic Strategy

    PubMed Central

    Morimoto, Sarah Shizuko; Gunning, Faith M.; Murphy, Christopher F.; Kanellopoulos, Dora; Kelly, Robert E.; Alexopoulos, George S.

    2013-01-01

    BACKGROUND This study tested the hypothesis that use of semantic organizational strategy in approaching the Mattis Dementia Rating Scale (MDRS) Complex Verbal Initiation Perseveration (I/P) task, a test of semantic fluency, is the function specifically associated with remission of late-life depression. METHOD 70 elders with major depression participated in a 12-week escitalopram treatment trial. Neuropsychological performance was assessed at baseline after a 2-week drug washout period. Patients with a Hamilton Depression Rating Scale Score less than or equal to 7 for two consecutive weeks and who no longer met DSM-IV criteria were considered to be remitted. Cox proportional hazards survival analysis was used to examine the relationship between subtests of the I/P, other neuropsychological domains and remission rate. Participants’ performance on the CV I/P was coded for perseverations, and use of semantic strategy. RESULTS The relationship of performance on the Complex Verbal I/P and remission rate was significant. No other subtest of the MDRS I/P evidenced this association. There was no significant relationship of speed, confrontation naming, verbal memory or perseveration with remission rate. Remitters’ use of verbal strategy was significantly greater than non-remitters. CONCLUSIONS Geriatric depressed patients who showed decrements in performance on a semantic fluency task showed poorer remission rates than those who showed adequate performance on this measure. Executive impairment in verbal strategy explained performance. This finding supports the concept that executive functioning exerts a “top down” effect on other basic cognitive processes, perhaps as a result of frontostriatal network dysfunction implicated in geriatric depression. PMID:20808124

  6. Trait Neuroticism, Depression, and Cognitive Function in Older Primary Care Patients

    PubMed Central

    Boyle, Lisa L.; Lyness, Jeffrey M.; Duberstein, Paul R.; Karuza, Jurgis; King, Deborah A.; Messing, Susan; Tu, Xin

    2010-01-01

    Objective Prior studies on the association of trait neuroticism and cognitive function in older adults have yielded mixed findings. We tested hypotheses that neuroticism is associated with measures of cognition and that depression moderates these relationships. Design Cross-sectional observational study. Setting Primary care offices. Participants Primary care patients age ≥65 years. Measurements Trait neuroticism was assessed by the NEO-Five Factor Inventory. Major and minor depression (MDD, MinD) were determined by the Structured Clinical Interview for DSM-IV, and depressive symptom severity by the Hamilton Depression Rating Scale (Ham-D). Cognitive measures included the Mini-Mental State Examination (MMSE), Initiation-Perseveration subscale of the Mattis Dementia Rating Scale, and Trail-Making Tests A and B. Results In multiple regression analyses, neuroticism was associated with MMSE score independent of depression diagnosis (β = −0.04, χ2 = 14.2, df = 1, p = 0.0002, 95% CI = −0.07, −0.02) and Ham-D score (β = −0.04, χ2 = 8.97, df = 1, p = 0.003, 95% CI = −0.06, −0.01). Interactions between neuroticism and depression diagnosis (χ2 = 7.21, df = 2, p = 0.03) and Ham-D scores (χ2 = 0.55, df = 1, p = 0.46) failed to lend strong support to the moderation hypothesis. Conclusion Neuroticism is associated with lower MMSE scores. Findings do not confirm a moderating role for depression, but suggest that depression diagnosis may confer additional risk for poorer global cognitive function in patients with high neuroticism. Further study is necessary. PMID:20220585

  7. Effectiveness of cognitive training for Chinese elderly in Hong Kong

    PubMed Central

    Kwok, Timothy; Wong, Anita; Chan, Grace; Shiu, YY; Lam, Ko-Chuen; Young, Daniel; Ho, Daniel WH; Ho, Florence

    2013-01-01

    In Hong Kong, the evidence for cognitive-training programs in fighting against memory complaints is lacking. This study aimed to evaluate the effectiveness of the Active Mind cognitive-training program in improving the cognitive function and quality of life (QoL) for local community-dwelling Chinese older adults. A total of 200 subjects were recruited from 20 different district elderly community centers (DECCs). Centers were randomly assigned into either the intervention group or control group. The intervention group underwent eight 1-hour sessions of cognitive training, while the control group were included in the usual group activities provided by the DECCs. Standardized neuropsychological tests (the Chinese version of Mattis Dementia Rating Scale [CDRS] and the Cantonese version of the Mini-Mental State Examination) and the QoL questionnaire SF12 were used to assess participants’ cognitive function and QoL before and after the trial. A total of 176 subjects completed the study. The intervention group showed greater improvement in the cognitive function measured by total CDRS score (treatment: 12.24 ± 11.57 vs control: 4.37 ± 7.99; P < 0.001) and QoL measured by total SF12 score (treatment: 7.82 ± 13.19 vs control: 3.18 ± 11.61; P = 0.014). Subjects with lower education level were associated with better cognitive response to the cognitive-training program. The current findings indicated that the Active Mind cognitive-training program was effective in improving the cognitive function and QoL for community-dwelling Chinese older adults in Hong Kong. PMID:23440076

  8. Application of Bogolyubov's theory of weakly nonideal Bose gases to the A+A, A+B, B+B reaction-diffusion system

    NASA Astrophysics Data System (ADS)

    Konkoli, Zoran

    2004-01-01

    Theoretical methods for dealing with diffusion-controlled reactions inevitably rely on some kind of approximation, and to find the one that works on a particular problem is not always easy. Here the approximation used by Bogolyubov to study a weakly nonideal Bose gas, referred to as the weakly nonideal Bose gas approximation (WBGA), is applied in the analysis of three reaction-diffusion models: (i) A+A→Ø, (ii) A+B→Ø, and (iii) A+A,B+B,A+B→Ø (the ABBA model). Two types of WBGA are considered, the simpler WBGA-I and the more complicated WBGA-II. All models are defined on the lattice to facilitate comparison with computer experiment (simulation). It is found that the WBGA describes the A+B reaction well, it reproduces the correct d/4 density decay exponent. However, it fails in the case of the A+A reaction and the ABBA model. (To cure the deficiency of WBGA in dealing with the A+A model, a hybrid of the WBGA and Kirkwood superposition approximations is suggested.) It is shown that the WBGA-I is identical to the dressed-tree calculation suggested by Lee [J. Phys. A 27, 2633 (1994)], and that the dressed-tree calculation does not lead to the d/2 density decay exponent when applied to the A+A reaction, as normally believed, but it predicts the d/4 decay exponent. Last, the usage of the small n0 approximation suggested by Mattis and Glasser [Rev. Mod. Phys. 70, 979 (1998)] is questioned if used beyond the A+B reaction-diffusion model.

  9. Therapeutic application of melatonin in mild cognitive impairment

    PubMed Central

    Cardinali, Daniel P; Vigo, Daniel E; Olivar, Natividad; Vidal, María F; Furio, Analía M; Brusco, Luis I

    2012-01-01

    Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome defined by cognitive impairment in advance of dementia. We previously reported in a retrospective analysis that daily 3 - 9 mg of a fast-release melatonin preparation given p. o. at bedtime for up to 3 years significantly improved cognitive and emotional performance and daily sleep/wake cycle in MCI patients. In a follow up of that study we now report data from another series of 96 MCI outpatients, 61 of who had received daily 3 - 24 mg of a fast-release melatonin preparation p. o. at bedtime for 15 to 60 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin exhibited significantly better performance in Mini–Mental State Examination and the cognitive subscale of the Alzheimer’s disease Assessment Scale. After application of a neuropsychological battery comprising a Mattis´ test, Digit-symbol test, Trail A and B tasks and the Rey´s verbal test, better performance was found in melatonin-treated patients for every parameter tested. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with the improvement in the quality of sleep and wakefulness. The comparison of the medication profile in both groups of MCI patients indicated that 9.8% in the melatonin group received benzodiazepines vs. 62.8% in the non-melatonin group. The results further support that melatonin can be a useful add-on drug for treating MCI in a clinic environment. PMID:23383398

  10. Apathy in patients with Parkinson disease without dementia or depression: a PET study.

    PubMed

    Robert, Gabriel; Le Jeune, Florence; Lozachmeur, Clément; Drapier, Sophie; Dondaine, Thibault; Péron, Julie; Travers, David; Sauleau, Paul; Millet, Bruno; Vérin, Marc; Drapier, Dominique

    2012-09-11

    We sought to identify apathy metabolic bases in Parkinson disease (PD). A total of 45 patients with PD who were not clinically depressed (Montgomery-Åsberg Depression Rating Scale [MADRS] <21) and had no dementia (Mattis Dementia Rating Scale [MDRS] >130) were assessed with the Apathy Evaluation Scale (AES) and underwent a resting-state F-18 fluorodeoxyglucose PET (FDG-PET) scan. A motor assessment comprising the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) was conducted and total levodopa equivalent daily dose (LEDD) was calculated. Imaging data were analyzed with statistical parametric mapping. Age, LEDD, and MDRS scores were introduced as covariates. Positive correlations were observed between the AES score and cerebral metabolism in the right inferior frontal gyrus (Brodmann area [BA] 47), right middle frontal gyrus (BA 10), right cuneus (BA 18), and right anterior insula (BA 13). Negative correlations were observed between the AES score and cerebellar metabolism in the semilunar lobules bilaterally, within the posterior lobe. Using an AES score equal to or above 42 to define clinical apathy, prevalence in our patient group was 17.8%. The AES score was negatively correlated with the MDRS score and positively correlated with the "retardation" subscore of the MADRS. It was not correlated with either UPDRS III or LEDD. Results indicate that the frontal, temporal, and cerebellar areas known to be involved in reward, emotion, and cognition are also implicated in apathy in patients with PD without dementia or depression. Their roles in the etiopathology of apathy are discussed.

  11. Apathy is related to cortex morphology in CADASIL. A sulcal-based morphometry study.

    PubMed

    Jouvent, E; Reyes, S; Mangin, J-F; Roca, P; Perrot, M; Thyreau, B; Hervé, D; Dichgans, M; Chabriat, H

    2011-04-26

    Apathy is a debilitating symptom in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the pathophysiology of which remains poorly understood. The aim of this study was to evaluate the neuroanatomic correlates of apathy, using new MRI postprocessing methods based on the identification of cortical sulci, in a large cohort of patients with CADASIL. A total of 132 patients with genetically confirmed diagnosis were included in this prospective cohort study. Global cognitive performances were assessed by the Mattis Dementia Rating Scale (MDRS) and disability by the modified Rankin score (mRS). Apathy was defined according to standard criteria. Depth, width, and cortical thickness of 10 large sulci of the frontal lobe in each hemisphere were measured. Logistic regression modeling was used to evaluate the links between apathy and cortical thickness, depth, or width of the different sulci. All models were adjusted for age, gender, level of education, MDRS, mRS, depression, and global brain volume. Complete MRI datasets of high quality were available in 119 patients. Depth of the posterior cingulate sulcus exhibited the strongest association with apathy in fully adjusted models (right: p value = 0.0006; left: p value = 0.004). Depth and width of cortical sulci in mediofrontal and orbitofrontal areas were independently associated with apathy. By contrast, cortical thickness was not. Cortical morphology in mediofrontal and orbitofrontal areas, by contrast to cortical thickness, is strongly and independently associated with apathy. These results suggest that apathy is related to a reduction of cortical surface rather than of cortical thickness secondary to lesion accumulation in CADASIL.

  12. Neuropsychological Correlates of Capacity Determinations in Alzheimer’s Disease: Implications for Assessment

    PubMed Central

    Palmer, Barton W.; Ryan, Kerry A.; Kim, H. Myra; Karlawish, Jason H.; Appelbaum, Paul S.; Kim, Scott Y. H.

    2011-01-01

    Objectives To explore the neuropsychological correlates of the capacity to consent to research and to appoint a research proxy among persons with Alzheimer’s disease. Design, Setting, and Participants Interview study of 77 persons with Alzheimer’s disease recruited through an Alzheimer’s disease research center and a memory disorder clinic. Measurements The capacity to consent to two research scenarios (a drug randomized clinical trial and a neurosurgical clinical trial) and the capacity to appoint a research proxy were determined by five experienced consultation psychiatrists who rendered categorical judgments based on videotaped interviews of the MacArthur Competence Assessment Tool-Clinical Research (MacCAT-CR) and the Capacity to Appoint a Proxy Assessment (CAPA). Mattis Dementia Rating Scale-2 (DRS-2) was used to assess neuropsychological functioning. Results The capacity to appoint a proxy and to consent to the drug randomized clinical trial, as determined by a majority or greater opinion of the 5-psychiatrist panel, were predicted by Conceptualization and Initiation/Perseveration subscales whereas the capacity to consent to a neurosurgical randomized clinical trial was predicted by the Memory subscale. Furthermore, the more lenient individual psychiatrists’ judgments were predicted by the Conceptualization subscale whereas the stricter psychiatrists’ judgments were predicted by the Memory subscale. Conclusions How experienced psychiatrists view Alzheimer’s patients’ capacity for consenting to research and for appointing a proxy may be related to the patients’ conceptualization and memory functioning. More explicit and standardized guidance on the role of short term memory in capacity determinations may be useful. PMID:23498384

  13. Impaired executive function can predict recurrent falls in Parkinson's disease.

    PubMed

    Mak, Margaret K; Wong, Adrian; Pang, Marco Y

    2014-12-01

    To examine whether impairment in executive function independently predicts recurrent falls in people with Parkinson's disease (PD). Prospective cohort study. University motor control research laboratory. A convenience sample of community-dwelling people with PD (N=144) was recruited from a patient self-help group and movement disorders clinics. Not applicable. Executive function was assessed with the Mattis Dementia Rating Scale Initiation/Perseveration (MDRS-IP) subtest, and fear of falling (FoF) with the Activities-specific Balance Confidence (ABC) Scale. All participants were followed up for 12 months to record the number of monthly fall events. Forty-two people with PD had at least 2 falls during the follow-up period and were classified as recurrent fallers. After accounting for demographic variables and fall history (P=.001), multiple logistic regression analysis showed that the ABC scores (P=.014) and MDRS-IP scores (P=.006) were significantly associated with future recurrent falls among people with PD. The overall accuracy of the prediction was 85.9%. With the use of the significant predictors identified in multiple logistic regression analysis, a prediction model determined by the logistic function was generated: Z = 1.544 + .378 (fall history) - .045 (ABC) - .145 (MDRS-IP). Impaired executive function is a significant predictor of future recurrent falls in people with PD. Participants with executive dysfunction and greater FoF at baseline had a significantly greater risk of sustaining a recurrent fall within the subsequent 12 months. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  14. Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction

    PubMed Central

    Gustavson, Kristen A.; Alexopoulos, George S; Niu, Grace C.; McCulloch, Charles; Meade, Tanya; Arean, Patricia A.

    2017-01-01

    Objective To test the hypothesis that Problem Solving Therapy (PST) is more effective than Supportive Therapy (ST) in reducing suicidal ideation in older adults with major depression and executive dysfunction. We further explored whether patient characteristics, such as age, gender and additional cognitive impairment load (eg: memory impairments) were related to changes in suicidal ideation over time. Design Secondary data analysis using data from a randomized clinical trial allocating participants to PST or ST at 1:1 ratio. Raters were blind to patients' assignments. Setting University medical centers. Participants 221 people aged 65 years old and older with major depression determined by SCID diagnosis and executive dysfunction as defined by a score of 33 or less on the Initiation-Perseveration Score of the Mattis Dementia Rating Scale or Stroop Interference Task score of 25 or less. Interventions 12 weekly sessions of Problem Solving Therapy or Supportive Therapy. Main Outcome Measures The suicide item of the Hamilton Depression Rating Scale (HDRS). Results Of the 221 participants, 61% reported suicidal ideation (SI). The ST group had a lower rate of improvement in SI after 12 weeks (44.6%) than did the PST group (60.4%, Fisher's exact test p = 0.031). Logistic regression showed significantly greater reductions in SI in elders who received PST at both 12 weeks (OR = .50, Z=-2.16, p = 0.031) and 36 weeks (OR=0.5, Z=-1.96, p=0.05) after treatment. Conclusion PST is a promising intervention for older adults who are at risk for suicide. PMID:26743100

  15. Frontiers in Numerical Relativity

    NASA Astrophysics Data System (ADS)

    Evans, Charles R.; Finn, Lee S.; Hobill, David W.

    2011-06-01

    Christopher S. Kochanek and Charles R. Evans; 22. Relativistic hydrodynamics James R. Wilson and Grant J. Mathews; 23. Computational dynamics of U(1) gauge strings: probability of reconnection of cosmic strings Richard A. Matzner; 24. Dynamically inhomogenous cosmic nucleosynthesis Hannu Kurki-Suonio; 25. Initial value solutions in planar cosmologies Peter Anninos, Joan Centrella and Richard Matzner; 26. An algorithmic overview of an Einstein solver Roger Ove; 27. A PDE compiler for full-metric numerical relativity Jonathan Thornburg; 28. Numerical evolution on null cones R. Gomez and J. Winicour; 29. Normal modes coupled to gravitational waves in a relativistic star Yasufumi Kojima; 30. Cosmic censorship and numerical relativity Dalia S. Goldwirth, Amos Ori and Tsvi Piran.

  16. Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients.

    PubMed

    Ardouin, C; Pillon, B; Peiffer, E; Bejjani, P; Limousin, P; Damier, P; Arnulf, I; Benabid, A L; Agid, Y; Pollak, P

    1999-08-01

    There is a renewal of interest in surgical approaches including lesions and deep brain stimulation directed at motor subcorticofrontal loops. Bilateral lesioning presents a far greater risk of adverse effects, especially cognitive impairment. Furthermore, the main advantages of the stimulation procedure over lesioning are adaptability and reversibility of effects. The aim of this study was to assess the influence of bilateral stimulation of the subthalamic nucleus or internal globus pallidus on memory and executive functions in Parkinson's disease. Sixty-two patients were assessed before and after 3 to 6 months of chronic bilateral stimulation of the subthalamic nucleus (n = 49) or internal globus pallidus (n = 13). The neuropsychological tests used were the Mattis Dementia Rating Scale, the Grober and Buschke Verbal Learning Test, the Wisconsin Card Sorting Test, category and literal fluency, graphic and motor series, the Stroop Test, and the Trail Making Test. Mood was evaluated by the Beck Depression Inventory. Only 4 of 25 cognitive variables were affected by deep brain stimulation. Under stimulation, performance improved for Parts A and B of the Trail Making Test, but there was a deterioration in literal and total lexical fluency. There was also a mild but significant improvement in mood. It may therefore be concluded that stimulation of the subthalamic nucleus or internal globus pallidus does not change the overall cognitive performance in Parkinson's disease and does not greatly affect the functioning of subcorticofrontal loops involved in cognition in humans. This relative absence of cognitive impairment in bilateral deep brain stimulation is likely because of the accurate positioning of the electrodes, allowing the effects of stimulation to be confined to sensorimotor circuits.

  17. The Structure and Molecular Parameters of Camphene Determined by Fourier Transform Microwave Spectroscopy and Quantum Chemical Calculations

    NASA Astrophysics Data System (ADS)

    Neeman, Elias M.; Dréan, Pascal; Huet, T. R.

    2016-06-01

    The emission of volatile organic compounds, from plants has strong revelance for plant physiology, plant ecology and atmospheric chemistry. Camphene (C10H16) is a bicyclic monoterpene which is emitted in the atmosphere by biogenic sources. The structure of the unique stable conformer was optimized using density functional theory and ab initio calculations. The rotational spectrum of camphene was recorded in a supersonic jet expansion with a Fourier transform microwave spectrometer over the range 2-20 GHz. Signals from the parent species and from the ten 13C isotopomers were observed in natural abundance. The rotational and centrifugal distortion parameters were fitted to a Watson's Hamiltonian in the A-reduction. A magnetic hyperfine structure associated with the pairs of hydrogen nuclei in the methylene groups was observed and modeled.The rotational constants coupled to the equilibrium structure calculations were used to determine the r_0 and the r_m(1) gas-phase geometries of the carbon skeleton. The present work provides the first spectroscopic characterization of camphene in the gas phase and these results are also relevant for ozonolysis kinetics study through Criegee intermediates. R. Baraldi, F. Rapparini, O. Facini, D. Spano and P. Duce, Journal of Mediterranean Ecology, Vol.6, No.1, (2005). A. Bracho-Nunez, N. M. Knothe, S. Welter, M. Staudt, W. R. Costa, M. A. R. Liberato, M. T. F. Piedade, and J. Kesselmeier Biogeosciences, 10, 5855-5873, (2013). Minna Kivimäenpää, Narantsetseg Magsarjav, Rajendra Ghimire, Juha-Matti Markkanen, Juha Heijari, Martti Vuorinen and Jarmo K. Holopainen, Atmospheric Environment, 60, 477-485, (2012). R.C. de M. Oliveira and G. F. Bauerfeldt, J. Phys. Chem. A, 119 2802-2812 (2015)

  18. Imaging Findings Associated with Cognitive Performance in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

    PubMed Central

    Meoded, Avner; Kwan, Justin Y.; Peters, Tracy L.; Huey, Edward D.; Danielian, Laura E.; Wiggs, Edythe; Morrissette, Arthur; Wu, Tianxia; Russell, James W.; Bayat, Elham; Grafman, Jordan; Floeter, Mary Kay

    2013-01-01

    Introduction Executive dysfunction occurs in many patients with amyotrophic lateral sclerosis (ALS), but it has not been well studied in primary lateral sclerosis (PLS). The aims of this study were to (1) compare cognitive function in PLS to that in ALS patients, (2) explore the relationship between performance on specific cognitive tests and diffusion tensor imaging (DTI) metrics of white matter tracts and gray matter volumes, and (3) compare DTI metrics in patients with and without cognitive and behavioral changes. Methods The Delis-Kaplan Executive Function System (D-KEFS), the Mattis Dementia Rating Scale (DRS-2), and other behavior and mood scales were administered to 25 ALS patients and 25 PLS patients. Seventeen of the PLS patients, 13 of the ALS patients, and 17 healthy controls underwent structural magnetic resonance imaging (MRI) and DTI. Atlas-based analysis using MRI Studio software was used to measure fractional anisotropy, and axial and radial diffusivity of selected white matter tracts. Voxel-based morphometry was used to assess gray matter volumes. The relationship between diffusion properties of selected association and commissural white matter and performance on executive function and memory tests was explored using a linear regression model. Results More ALS than PLS patients had abnormal scores on the DRS-2. DRS-2 and D-KEFS scores were related to DTI metrics in several long association tracts and the callosum. Reduced gray matter volumes in motor and perirolandic areas were not associated with cognitive scores. Conclusion The changes in diffusion metrics of white matter long association tracts suggest that the loss of integrity of the networks connecting fronto-temporal areas to parietal and occipital areas contributes to cognitive impairment. PMID:24052798

  19. Changes in Brain Volume and Cognition in a Randomized Trial of Exercise and Social Interaction in a Community-Based Sample of Non-Demented Chinese Elders

    PubMed Central

    Mortimer, James A.; Ding, Ding; Borenstein, Amy R.; DeCarli, Charles; Guo, Qihao; Wu, Yougui; Zhao, Qianhua; Chu, Shugang

    2013-01-01

    Physical exercise has been shown to increase brain volume and improve cognition in randomized trials of non-demented elderly. Although greater social engagement was found to reduce dementia risk in observational studies, randomized trials of social interventions have not been reported. A representative sample of 120 elderly from Shanghai, China was randomized to four groups (Tai Chi, Walking, Social Interaction, No Intervention) for 40 weeks. Two MRIs were obtained, one before the intervention period, the other after. A neuropsychological battery was administered at baseline, 20 weeks, and 40 weeks. Comparison of changes in brain volumes in intervention groups with the No Intervention group were assessed by t-tests. Time-intervention group interactions for neuropsychological measures were evaluated with repeated-measures mixed models. Compared to the No Intervention group, significant increases in brain volume were seen in the Tai Chi and Social Intervention groups (p < 0.05). Improvements also were observed in several neuropsychological measures in the Tai Chi group, including the Mattis Dementia Rating Scale score (p = 0.004), the Trailmaking Test A (p = 0.002) and B (p = 0.0002), the Auditory Verbal Learning Test (p = 0.009), and verbal fluency for animals (p = 0.01). The Social Interaction group showed improvement on some, but fewer neuropsychological indices. No differences were observed between the Walking and No Intervention groups. The findings differ from previous clinical trials in showing increases in brain volume and improvements in cognition with a largely non-aerobic exercise (Tai Chi). In addition, intellectual stimulation through social interaction was associated with increases in brain volume as well as with some cognitive improvements. PMID:22451320

  20. Genetic influences on cognitive decline in Parkinson's disease

    PubMed Central

    Morley, J.F.; Xie, S.X.; Hurtig, H.I.; Stern, M.B.; Colcher, A.; Horn, S.; Dahodwala, N.; Duda, J.E.; Weintraub, D.; Chen-Plotkin, A.S.; Van Deerlin, V.; Falcone, D.; Siderowf, A.

    2012-01-01

    Background The role of genetic factors in cognitive decline associated with Parkinson's disease is unclear. We examined whether variations in apolipoprotein E, microtubule-associated protein tau or catechol-O-methytransferase genotypes are associated with cognitive decline in Parkinson's disease. Methods We performed a prospective cohort study of 212 patients with a clinical diagnosis of Parkinson's disease. The primary outcome was change in Mattis Dementia Rating Scale version 2 score. Linear mixed-effects models and survival analysis were used to test for associations between genotypes and change in cognitive function over time. Results The ε4 allele of apoliporotein E was associated with more rapid decline (loss of 2.9 (95% CI, 1.7–4.1) more points/year, p<0.001) in total score and an increased risk of a ≥10 pointdrop during the follow-up period (HR 2.8, 95% CI 1.4–5.4, p=0.003). Microtubule-associated protein tau haplotype and catechol-O-methytransferase genotype were associated with measures of memory and attention, respectively, over the entire followup period but not with the overall rate of cognitive decline. Conclusion These results confirm and extend previously described genetic associations with cognitive decline in Parkinson's disease and imply that individual genes may exert effects on specific cognitive domains or at different disease stages. Carrying at least one apolipoprotein E ε4 allele is associated with more rapid cognitive decline in Parkinson's disease, supporting the idea of a component of shared etiology between Parkinson's disease dementia and Alzheimer disease. Clinically, these results suggest genotyping can provide information about the risk of future cognitive decline for Parkinson's disease patients. PMID:22344634

  1. Renormalization Group Studies and Monte Carlo Simulation for Quantum Spin Systems.

    NASA Astrophysics Data System (ADS)

    Pan, Ching-Yan

    We have discussed the extended application of various real space renormalization group methods to the quantum spin systems. At finite temperature, we extended both the reliability and range of application of the decimation renormalization group method (DRG) for calculating the thermal and magnetic properties of low-dimensional quantum spin chains, in which we have proposed general models of the three-state Potts model and the general Heisenberg model. Some interesting finite-temperature behavior of the models has been obtained. We also proposed a general formula for the critical properties of the n-dimensional q-state Potts model by using a modified migdal-Kadanoff approach which is in very good agreement with all available results for general q and d. For high-spin systems, we have investigated the famous Haldane's prediction by using a modified block renormalization group approach in spin -1over2, spin-1 and spin-3 over2 cases. Our result supports Haldane's prediction and a novel property of the spin-1 Heisenberg antiferromagnet has been predicted. A modified quantum monte Carlo simulation approach has been developed in this study which we use to treat quantum interacting problems (we only work on quantum spin systems in this study) without the "negative sign problem". We also obtain with the Monte Carlo approach the numerical derivative directly. Furthermore, using this approach we have obtained the energy spectrum and the thermodynamic properties of the antiferromagnetic q-state Potts model, and have studied the q-color problem with the result which supports Mattis' recent conjecture of entropy for the n -dimensional q-state Potts antiferromagnet. We also find a general solution for the q-color problem in d dimensions.

  2. Changes in brain volume and cognition in a randomized trial of exercise and social interaction in a community-based sample of non-demented Chinese elders.

    PubMed

    Mortimer, James A; Ding, Ding; Borenstein, Amy R; DeCarli, Charles; Guo, Qihao; Wu, Yougui; Zhao, Qianhua; Chu, Shugang

    2012-01-01

    Physical exercise has been shown to increase brain volume and improve cognition in randomized trials of non-demented elderly. Although greater social engagement was found to reduce dementia risk in observational studies, randomized trials of social interventions have not been reported. A representative sample of 120 elderly from Shanghai, China was randomized to four groups (Tai Chi, Walking, Social Interaction, No Intervention) for 40 weeks. Two MRIs were obtained, one before the intervention period, the other after. A neuropsychological battery was administered at baseline, 20 weeks, and 40 weeks. Comparison of changes in brain volumes in intervention groups with the No Intervention group were assessed by t-tests. Time-intervention group interactions for neuropsychological measures were evaluated with repeated-measures mixed models. Compared to the No Intervention group, significant increases in brain volume were seen in the Tai Chi and Social Intervention groups (p < 0.05). Improvements also were observed in several neuropsychological measures in the Tai Chi group, including the Mattis Dementia Rating Scale score (p = 0.004), the Trailmaking Test A (p = 0.002) and B (p = 0.0002), the Auditory Verbal Learning Test (p = 0.009), and verbal fluency for animals (p = 0.01). The Social Interaction group showed improvement on some, but fewer neuropsychological indices. No differences were observed between the Walking and No Intervention groups. The findings differ from previous clinical trials in showing increases in brain volume and improvements in cognition with a largely non-aerobic exercise (Tai Chi). In addition, intellectual stimulation through social interaction was associated with increases in brain volume as well as with some cognitive improvements.

  3. Predictors of performance-based measures of instrumental activities of daily living in nondemented patients with Parkinson's disease.

    PubMed

    Pirogovsky, Eva; Martinez-Hannon, Mercedes; Schiehser, Dawn M; Lessig, Stephanie L; Song, David D; Litvan, Irene; Filoteo, J Vincent

    2013-01-01

    Few studies have examined instrumental activities of daily living (iADLs) in nondemented Parkinson's disease (PD), and the majority of these studies have used report-based measures, which can have limited validity. The present study had two main goals: (a) to examine the performance of nondemented PD patients on two performance-based measures of iADLs, which are considered more objective functional measures, and (b) to examine the cognitive, motor, and psychiatric correlates of iADL impairment in PD. Ninety-eight nondemented PD patients and 47 healthy older adults were administered performance-based measures that assess the ability to manage medications (Medication Management Ability Assessment) and finances (University of California, San Diego, UCSD, Performance-based Skills Assessment), the Mattis Dementia Rating Scale to assess global cognitive functioning, the Unified Parkinson's Disease Rating Scale Part III to assess motor symptom severity, and the Geriatric Depression Scale to assess depressive symptoms. Nondemented PD patients demonstrated significantly impaired scores relative to the healthy comparison group on the performance-based measure of financial management, but there were no significant group differences in medication management. Global cognitive functioning, motor severity, and depressive symptoms did not correlate with scores on either of the functional measures, except for a small correlation between depressive symptoms and financial management. The two performance-based measures of iADL functioning did not correlate with one another. These findings suggest that medication and financial management may not be predicted based on global cognitive functioning and that iADLs may not be represented by a single construct. Furthermore, these findings suggest the potential need for a multidimensional approach to assessing iADLs.

  4. PREFACE: First International Congress of the International Association of Inverse Problems (IPIA): Applied Inverse Problems 2007: Theoretical and Computational Aspects

    NASA Astrophysics Data System (ADS)

    Uhlmann, Gunther

    2008-07-01

    , Finland), Masahiro Yamamoto (University of Tokyo, Japan), Gunther Uhlmann (University of Washington) and Jun Zou (Chinese University of Hong Kong). IPIA is a recently formed organization that intends to promote the field of inverse problem at all levels. See http://www.inverse-problems.net/. IPIA awarded the first Calderón prize at the opening of the conference to Matti Lassas (see first article in the Proceedings). There was also a general meeting of IPIA during the workshop. This was probably the largest conference ever on IP with 350 registered participants. The program consisted of 18 invited speakers and the Calderón Prize Lecture given by Matti Lassas. Another integral part of the program was the more than 60 mini-symposia that covered a broad spectrum of the theory and applications of inverse problems, focusing on recent developments in medical imaging, seismic exploration, remote sensing, industrial applications, numerical and regularization methods in inverse problems. Another important related topic was image processing in particular the advances which have allowed for significant enhancement of widely used imaging techniques. For more details on the program see the web page: http://www.pims.math.ca/science/2007/07aip. These proceedings reflect the broad spectrum of topics covered in AIP 2007. The conference and these proceedings would not have happened without the contributions of many people. I thank all my fellow organizers, the invited speakers, the speakers and organizers of mini-symposia for making this an exciting and vibrant event. I also thank PIMS, NSF and MITACS for their generous financial support. I take this opportunity to thank the PIMS staff, particularly Ken Leung, for making the local arrangements. Also thanks are due to Stephen McDowall for his help in preparing the schedule of the conference and Xiaosheng Li for the help in preparing these proceedings. I also would like to thank the contributors of this volume and the referees. Finally

  5. Executive cognitive tests for the evaluation of patients with Parkinson’s disease

    PubMed Central

    Sobreira, Emmanuelle Silva Tavares; Pena, Marina Ceres Silva; Silva Filho, José Humberto; Souza, Carolina Pinto; Oliveira, Guiomar Nascimento; Tumas, Vitor; do Vale, Francisco de Assis Carvalho

    2008-01-01

    Parkinson’s disease (PD) is characterized by changes in movement, which are later followed by cognitive, behavioral and psychological changes. The objective of the present study was to correlate different tests used to examine executive functions in PD patients followed at a specialized outpatient clinic. Methods Thirty-five patients with idiopathic PD aged 63.0 years on average and with mean schooling of 5.5±4.2 years, were examined using the following tests: Mattis Dementia Rating Scale (MDRS), Scales for Outcomes of Parkinson’s Disease-Cognition (SCOPA-COG), Wisconsin Card Sorting Test (WCST), Frontal Assessment Battery (FAB), Digit Span – Inverse Order (IO) (a subtest of the WAIS III) and Verbal Fluency Test (category animals). Results Significant correlations were detected between FAB and MDRS Conceptualization (0.814), MDRS Initiation/Perseveration (I/P) and SCOPA-COG Executive Function (0.643), FAB and MDRS I/P (0.601), FAB and Verbal Fluency (0.602), MDRS I/P and MDRS Conceptualization (0.558), Verbal Fluency and MDRS I/P (0.529), MDRS Attention and SCOPA-COG Executive Function (0.495), MDRS Conceptualization and SCOPA-COG Executive Function (0.520), FAB and Digit Span (OI) (0.503), Verbal Fluency and MDRS Conceptualization (0.501), and WCST perseverative errors and FAB (–0.379), WCST perseverative errors and MDRS Conceptualization (0.445), WCST perseverative errors and MDRS I/P (–0.407) and WCST categories completed and MDRS Conceptualization (0.382). Discussion The results demonstrated strong correlations between most of the tests applied, but no associations were detected between the WCST and the other tests, a fact that may be explained by the heterogeneity of scores obtained in the tests by the patients evaluated. A difficulty of the present study was the lack of a control groups for the establishment of adequate standards for this population. PMID:29213572

  6. Cognitive impairment and PD patients' capacity to consent to research

    PubMed Central

    Cary, Mark; Moelter, Stephen T.; Siderowf, Andrew; Sullo, Elizabeth; Xie, Sharon; Weintraub, Daniel

    2013-01-01

    Objective: To examine how cognitive impairment affects Parkinson disease (PD) patients' research consent capacity. Methods: A cross-sectional study of 90 patients with PD, divided using Mattis Dementia Rating Scale–2 scores into 3 groups of 30 (normal, borderline, and impaired), and 30 neurologically normal older adults completed 2 capacity interviews (an early-phase randomized and controlled drug trial and a sham-controlled surgical implantation of genetic tissue) using the MacArthur Competence Assessment Tool for Clinical Research. Expert clinicians used the interviews to classify the patients as either capable or not capable of providing their own informed consent. These judgments were compared with performance on the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Results: Cognitively normal PD patients typically scored well on the capacity measures. In contrast, patients with impaired cognition were not capable of providing their own informed consent: 17% (5/30) on the drug trial and 3% (1/30) on the surgery trial were judged capable. Patients with borderline impairment showed adequate performance on measures of appreciation and reasoning, but impaired performance on understanding the drug trial compared with normal controls and normal PD patients, and on understanding the surgery trial compared with normal controls. Sixty-seven percent (20/30) on the drug trial and 57% (17/30) on the surgery trial were judged capable of consent. Receiver operating characteristic analyses showed that the MMSE and MoCA could detect the likelihood of impaired capacity, with the MoCA demonstrating greater sensitivity. Conclusions: PD patients with borderline cognitive impairment have impairments in their decisional capacity. The MoCA may be useful to identify the patients at risk of impaired capacity. PMID:23892706

  7. Memory, Mood, and Vitamin D in Persons with Parkinson’s Disease

    PubMed Central

    Peterson, Amie L.; Murchison, Charles; Zabetian, Cyrus; Leverenz, James B.; Watson, G. Stennis; Montine, Thomas; Carney, Natasha; Bowman, Gene L.; Edwards, Karen; Quinn, Joseph F.

    2014-01-01

    Background Research in recent years has suggested a role of vitamin D in the central nervous system. The final converting enzyme and the vitamin D receptor are found throughout the human brain. From animal studies vitamin D appears important in neurodevelopment, up-regulation of neurotrophic factors, stabilization of mitochondrial function, and antioxidation. Objective To examine the relationship between serum vitamin D and neuropsychiatric function in persons with Parkinson’s disease (PD). Methods This is an add-on study to a longitudinal study following neuropsychiatric function in persons with PD. Baseline neuropsychiatric performance and serum 25-hydroxyvitamin D were examined for 286 participants with PD. Measures of global cognitive function (MMSE, MOCA, Mattis Dementia Scale), verbal memory (Hopkins Verbal Learning Test), fluency (animals, vegetables, and FAS words), visuospatial function (Benton Line Orientation), executive function (Trails Making Test and Digit-Symbol Substitution), PD severity (Hoehn & Yahr and Unified Parkinson’s Disease Rating Scale) and depression (Geriatric Depression Scale (GDS)) were administered. Multivariate linear regression assessed the association between vitamin D concentration and neuropsychiatric function, in the entire cohort as well as the non-demented and demented subsets. Results Using a multivariate model, higher vitamin concentrations were associated with better performance on numerous neuropsychiatric tests in the non-demented subset of the cohort. Significant associations were specifically found between vitamin D concentration and verbal fluency and verbal memory (t = 4.31, p < 0.001 and t = 3.04, p = 0.0083). Vitamin D concentrations also correlated with depression scores (t =−3.08, p = 0.0083) in the non-demented subset. Conclusions Higher plasma vitamin D is associated with better cognition and better mood in this sample of PD patients without dementia. Determination of causation will require a vitamin D

  8. Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy.

    PubMed

    Gnann, John W; Sköldenberg, Birgit; Hart, John; Aurelius, Elisabeth; Schliamser, Silvia; Studahl, Marie; Eriksson, Britt-Marie; Hanley, Daniel; Aoki, Fred; Jackson, Alan C; Griffiths, Paul; Miedzinski, Lil; Hanfelt-Goade, Diane; Hinthorn, Daniel; Ahlm, Clas; Aksamit, Allen; Cruz-Flores, Salvador; Dale, Ilet; Cloud, Gretchen; Jester, Penelope; Whitley, Richard J

    2015-09-01

    Despite the proven efficacy of acyclovir (ACV) therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with ACV, the mortality rate is approximately 14%-19%. Among survivors, 45%-60% have neuropsychological sequelae at 1 year. Thus, improving therapeutic approaches to HSE remains a high priority. Following completion of a standard course of intravenous ACV, 87 adult patients with HSE (confirmed by positive polymerase chain reaction [PCR] for herpes simplex virus DNA in cerebrospinal fluid) were randomized to receive either valacyclovir (VACV) 2 g thrice daily (n = 40) or placebo tablets (n = 47) for 90 days (12 tablets of study medication daily). The primary endpoint was survival with no or mild neuropsychological impairment at 12 months, as measured by the Mattis Dementia Rating Scale (MDRS). Logistic regression was utilized to assess factors related to the primary endpoint. The demographic characteristics of the 2 randomization groups were statistically similar with no significant differences in age, sex, or race. At 12 months, there was no significant difference in the MDRS scoring for VACV-treated vs placebo recipients, with 85.7% and 90.2%, respectively, of patients demonstrating no or mild neuropsychological impairment (P = .72). No significant study-related adverse events were encountered in either treatment group. Following standard treatment with intravenous ACV for PCR-confirmed HSE, an additional 3-month course of oral VACV therapy did not provide added benefit as measured by neuropsychological testing 12 months later in a population of relatively high-functioning survivors. NCT00031486. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  9. Neuropsychological and clinical heterogeneity of cognitive impairment in patients with multiple system atrophy.

    PubMed

    Barcelos, Lorena Broseghini; Saad, Flávia; Giacominelli, Carla; Saba, Roberta Arb; de Carvalho Aguiar, Patrícia Maria; Silva, Sonia Maria Azevedo; Borges, Vanderci; Bertolucci, Paulo Henrique Ferreira; Ferraz, Henrique Ballalai

    2018-01-01

    We evaluated neuropsychological tests to compare cognitive impairment between two types of multiple system atrophy: predominant parkinsonism (MSA-P) and predominant cerebellar ataxia (MSA-C). This cross-sectional study included 14 patients diagnosed with MSA: four with MSA-C and ten with MSA-P. Presence of motor symptoms was determined by using the Unified Rating MSA Scale (URMSAS). Non-motor symptoms were evaluated by the Short Form Health Survey (SF-36), Scales for Outcomes in Parkinson's disease Autonomic (SCOPA-AUT), Hospital Anxiety and Depression Scale (HADS), and Beck Depression Inventory (BDI). Neuropsychological tests were used to evaluate general cognition, verbal and visual memory, working memory, constructional ability, visuospatial, language, and executive function. The median age of the patients was 62 years, median disease duration was 3.5 years, and median education level was 10 years. The median Mini-Mental State Examination (MMSE) score was 26.5 points, and median Mattis Dementia Rating Scale (MDRS) score was 131.5. We compared the continuous data between the two MSA subtypes and observed that bodily pain reported in the quality of life questionnaire, SF-36, was worse in MSA-P (p<0.05), and attention function evaluated by MDRS was significantly lower in MSA-C than MSA-P (p<0.05). Our comparative study of cognitive impairment in MSA-P and MSA-C showed that both groups had impaired executive and visuospatial functions, while the attention deficit was predominant only in MSA-C. These findings support the concept that cognitive deficit originates from striatofrontal dysfunction and cerebellar degeneration. Our study also suggests that cognitive impairment is relevant in MSA, and clinical neurologists should not neglect evaluation of these aspects in their daily clinical practice. Copyright © 2017. Published by Elsevier B.V.

  10. Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease

    PubMed Central

    Silverberg, Gerald; Mayo, Martha; Saul, Thomas; Fellmann, Jere; McGuire, Dawn

    2006-01-01

    Background Abnormalities in cerebrospinal fluid (CSF) production and turnover, seen in normal pressure hydrocephalus (NPH) and in Alzheimer's disease (AD), may be an important cause of amyloid retention in the brain and may relate the two diseases. There is a high incidence of AD pathology in patients being shunted for NPH, the AD-NPH syndrome. We now report elevated CSF pressure (CSFP), consistent with very early hydrocephalus, in a subset of AD patients enrolled in a clinical trial of chronic low-flow CSF drainage. Our objective was to determine the frequency of elevated CSFP in subjects meeting National Institutes of Neurological and Communicative Diseases and Stroke – Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for AD, excluding those with signs of concomitant NPH. Methods AD subjects by NINCDS-ADRDA criteria (n = 222), were screened by history, neurological examination, and radiographic imaging to exclude those with clinical or radiographic signs of NPH. As part of this exclusion process, opening CSFP was measured supine under general anesthesia during device implantation surgery at a controlled pCO2 of 40 Torr (40 mmHg). Results Of the 222 AD subjects 181 had pressure measurements recorded. Seven subjects (3.9%) enrolled in the study had CSFP of 220 mmH20 or greater, mean 249 ± 20 mmH20 which was significantly higher than 103 ± 47 mmH2O for the AD-only group. AD-NPH patients were significantly younger and significantly less demented on the Mattis Dementia Rating Scale (MDRS). Conclusion Of the AD subjects who were carefully screened to exclude those with clinical NPH, 4% had elevated CSFP. These subjects were presumed to have the AD-NPH syndrome and were withdrawn from the remainder of the study. PMID:16737542

  11. Dopamine and the Biology of Creativity: Lessons from Parkinson’s Disease

    PubMed Central

    Lhommée, Eugénie; Batir, Alina; Quesada, Jean-Louis; Ardouin, Claire; Fraix, Valérie; Seigneuret, Eric; Chabardès, Stéphan; Benabid, Alim-Louis; Pollak, Pierre; Krack, Paul

    2014-01-01

    Background: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization, and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists. Methods: Eleven consecutive creative PD patients were selected from candidates for subthalamic nucleus deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal score, Mattis scale), and behavior (Ardouin scale) were assessed before surgery and 1 year after. Results: Before surgery, whereas cognitive and motor assessments were similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (p = 0.01). The Ardouin scale revealed also a specific psycho-behavioral profile of creative patients which had higher scores for mania (p < 0.001), hobbyism (p = 0.001), nocturnal hyperactivity (p = 0.041), appetitive functioning (p = 0.003), and ON euphoria (p = 0.007) and lower scores for apathy and OFF dysphoria (p = 0.04 for each). Post-operative motor, cognitive, and behavioral scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only 1 of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ = 0.47 with confidence index of 95% = 0.16; 0.70, p = 0.0053). Conclusion: Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists

  12. Parkinson's disease-cognitive rating scale: psychometrics for mild cognitive impairment.

    PubMed

    Fernández de Bobadilla, Ramón; Pagonabarraga, Javier; Martínez-Horta, Saül; Pascual-Sedano, Berta; Campolongo, Antonia; Kulisevsky, Jaime

    2013-09-01

    Lack of validated data on cutoff scores for mild cognitive impairment (MCI) and sensitivity to change in predementia stages of Parkinson's disease (PD) limit the utility of instruments measuring global cognition as screening and outcome measures in therapeutic trials. Investigators who were blinded to PD-Cognitive Rating Scale (PD-CRS) scores classified a cohort of prospectively recruited, nondemented patients into a PD with normal cognition (PD-NC) group and a PD with MCI (PD-MCI) group using Clinical Dementia Rating (CDR) and the Mattis Dementia Rating Scale-2 (MDRS-2). The discriminative power of the PD-CRS for PD-MCI was examined in a representative sample of 234 patients (145 in the PD-NC group; 89 in the PD-MCI group) and in a control group of 98 healthy individuals. Sensitivity to change in the PD-CRS score (the minimal clinically important difference was examined with the Clinical Global Impression of Change scale and was calculated with a combination of distribution-based and anchor-based approaches) was explored in a 6-month observational multicenter trial involving a subset of 120 patients (PD-NC, 63; PD-MCI, 57). Regression analysis demonstrated that PD-CRS total scores (P < 0.001) and age (P = 0.01) independently differentiated PD-NC from PD-MCI. Area under the receiver operating characteristic curve (AUC) analysis (AUC, 0.85; 95% confidence interval, 0.80-0.90) indicated that a score ≤ 81 of 134 was the optimal cutoff point on the total score for the PD-CRS (sensitivity, 79%; specificity, 80%; positive predictive value, 59%; negative predictive value, 91%). A range of change from 10 to 13 points on the PD-CRS total score was indicative of clinically significant change. These findings suggest that the PD-CRS is a useful tool to identify PD-MCI and to track cognitive changes in nondemented patients with PD. © 2013 International Parkinson and Movement Disorder Society.

  13. Efficacy and safety of Ginkgo biloba standardized extract in the treatment of vascular cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial

    PubMed Central

    Demarin, Vida; Bašić Kes, Vanja; Trkanjec, Zlatko; Budišić, Mislav; Bošnjak Pašić, Marija; Črnac, Petra; Budinčević, Hrvoje

    2017-01-01

    Objectives The aim of this randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of Ginkgo biloba extract in patients diagnosed with vascular cognitive impairment (VCI). Methods A total of 90 patients (aged 67.1±8.0 years; 59 women) were randomly allocated (1:1:1) to receive G. biloba 120 mg, G. biloba 60 mg, or placebo during a 6-month period. Assessment was made for efficacy indicators, including neuropsychological tests scores (Sandoz Clinical Assessment Geriatric Scale, Folstein Mini-Mental State Examination, Mattis Dementia Rating Scale, and Clinical Global Impression) and transcranial Doppler ultrasound findings. Safety indicators included laboratory findings, reported adverse reactions, and clinical examination. Results At the end of 6-month study period, G. biloba 120 and 60 mg showed a statistically significant positive effect in comparison with placebo only on the Clinical Global Impression score (2.6±0.8 vs 3.1±0.7 vs 2.8±0.7, respectively; P=0.038). The Clinical Global Impression score showed a significant deterioration from the baseline values in the placebo group (−0.3±0.5; P=0.021) as opposed to G. biloba groups. No significant differences were found in the transcranial Doppler ultrasound findings. Adverse reactions were significantly more common and serious in the placebo group (16 subjects) than in either of the two G. biloba extract groups (eight and nine subjects, respectively), whereas laboratory findings and clinical examinations revealed no differences between the groups receiving G. biloba extract and placebo. Conclusion According to our results, G. biloba seemed to slow down the cognitive deterioration in patients with VCI, but the effect was shown in only one of the four neuropsychological tests administered. However, because of this mild effect in combination with a few adverse reactions, we cannot say that it is ineffective or unsafe either. Further studies are still needed to provide

  14. Long-term impact of subthalamic stimulation on cognitive function in patients with advanced Parkinson's disease.

    PubMed

    Acera, M; Molano, A; Tijero, B; Bilbao, G; Lambarri, I; Villoria, R; Somme, J; Ruiz de Gopegui, E; Gabilondo, I; Gomez-Esteban, J C

    2017-07-13

    The aim of this study was to evaluate the effects of deep brain stimulation of the subthalamic nucleus (DBS-SN) on cognitive function in patients with Parkinson's disease (PD) 5 years after surgery. We conducted a prospective study including 50 patients with PD who underwent DBS-SN (62.5% were men; mean age of 62.2±8.2 years; mean progression time of 14.1±6.3 years). All patients were assessed before the procedure and at one year after surgery; 40 patients were further followed up until the 5-year mark. Follow-up assessments included the following neuropsychological tests: Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale (MDRS), letter-number sequencing of the WAIS-III (WAIS-III-LN), clock-drawing test, Rey auditory verbal learning test (RAVLT), Benton Visual Retention Test (BVRT), Judgment of Line Orientation (JLO) test, FAS Phonemic Verbal Fluency Test, Stroop test, and the Montgomery-Asberg Depression Rating Scale (MADRS). Patients were found to score lower on the MMSE (-0.89%), clock-drawing test (-2.61%), MDRS (-1.72%), and especially phonemic (-13.28%) and sematic verbal fluency tests (-12.40%) at one year after surgery. Delayed recall on the RAVLT worsened one year after the procedure (-10.12%). At 5 years, impairment affected mainly verbal fluency; scores decreased an additional 16.10% and 16.60% in semantic and phonemic verbal fluency, respectively. Moderate decreases were observed in immediate recall (-16.87%), WAIS-III-LN (-16.67%), and JLO test (-11.56%). In our sample, DBS-SN did not result in global cognitive impairment 5 years after surgery. Verbal function was found to be significantly impaired one year after the procedure. Impaired learning and visuospatial function may be attributed to degeneration associated with PD. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. On the instrumental characterization of a 3-λ scanning lidar to monitor industrial flames and its application for retrieving optical and microphysical properties

    NASA Astrophysics Data System (ADS)

    Guerrero-Rascado, Juan Luis; da Costa, Renata; Esteban Bedoya, Andrés; Guardani, Roberto; Alados-Arboledas, Lucas; Efrain Bastidas, Álvaro; Landulfo, Eduardo

    2015-04-01

    The emission of pollutants in megacities and industrial areas can have strong impact, not only from an environmental point of view, but also for human health. Cubatão (23° 53' S, 46° 26' W, 10 m asl) has been one of the most industrialized city in Brazil (located at São Paulo state coast) during the last decades. This work deals with the recent advances made on a 3-λ scanning lidar placed at this industrial region. Special attention has been paid to the characterization of the electronic performance of this lidar system. For this goal, the quality assurance tests, regularly applied in well-established lidar networks such as LALINET [Guerrero-Rascado et al., 2014] and EARLINET [Pappalardo et al. 2014], were applied to the Cubatão scanning lidar in order to improve the knowledge of its performing itself and to design protocols for correcting lidar signal for undesirable instrumental effects. The application of the results derived from these quality assurance tests together with the state-of-the-art methodologies to map the particle optical and microphysical properties inside industrial flares demonstrate the potential of this lidar for the study and measurement of industrial emissions. References: J. L. Guerrero-Rascado, E. Landulfo, J. C. Antuña, H. M. J. Barbosa, B. Barja, A. E. Bastidas, A. E. Bedoya, R. da Costa, R. Estevan, R. N. Forno, D. A. Gouveia, C. Jiménez, E. G. Larroza, F. J. S. Lopes, E. Montilla-Rosero, G. A. Moreira, W. M. Nakaema, D. Nisperuza, L. Otero, J. V. Pallotta, S. Papandrea, E. Pawelko, E. J. Quel, P. Ristori, P. F. Rodrigues, J. Salvador, M. F. Sánchez, and A. Silva, "Towards an instrumental harmonization in the framework of LAINET: dataset of technical specifications", Proceedings of SPIE 2014, vol. 9246, 92460O-1 -- 92460O-14, doi: 10.1117/12.2066873 (2014) G. Pappalardo, A. Amodeo, A. Apituley, A. Comerón, V. Freudenthaler, H. Linné, A. Ansmann, J. Bösenberg, G. D'Amico, I. Mattis, L. Mona, U. Wandinger, V. Amiridis, L

  16. Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment.

    PubMed

    Chen, Jiu; Shu, Hao; Wang, Zan; Zhan, Yafeng; Liu, Duan; Liao, Wenxiang; Xu, Lin; Liu, Yong; Zhang, Zhijun

    2016-10-01

    Both remitted late-life depression (rLLD) and amnesiac mild cognitive impairment (aMCI) alter brain functions in specific regions of the brain. They are also disconnection syndromes that are associated with a high risk of developing Alzheimer's disease (AD). Resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) was performed to define the shared and distinct aberrant patterns in intranetwork and internetwork connectivity between rLLD and aMCI and to determine how knowledge of these differences might contribute to our essential understanding of the altered sequences involved in functional systems both inside and outside of resting-state networks. We used rs-fcMRI to investigate in five functionally well-defined brain networks in two large cohorts of subjects at high risk for AD (55 rLLD and 87 aMCI) and 114 healthy controls (HC). A reduced degree of functional connectivity was observed in the bilateral inferior temporal cortex and supplemental motor area, and reduced correlations were observed within the sensory-motor network (SMN) and in the default mode network (DMN)-control network (CON) pair in the rLLD group than the HC group. The aMCI group showed only focal functional changes in regions of interest pairs, a trend toward increased correlations within the salience network and SMN, and a trend toward a reduced correlation in the DMN-CON pair. Furthermore, the rLLD group exhibited more severely altered functional connectivity than the aMCI group. Interestingly, these altered connectivities were associated with specific multi-domain cognitive and behavioral functions in both rLLD and aMCI. The degree of functional connectivity in the right primary auditory areas was negatively correlated with Hamilton Depression Scale scores in rLLD. Notably, altered connectivity between the right middle temporal cortex and the posterior cerebellum was negatively correlated with Mattis Dementia Rating Scale scores in both rLLD and aMCI. These results

  17. Introducing litter quality to the ecosystem model LPJ-GUESS: Effects on short- and long-term soil carbon dynamics

    NASA Astrophysics Data System (ADS)

    Portner, Hanspeter; Wolf, Annett; Rühr, Nadine; Bugmann, Harald

    2010-05-01

    and 2007 [Rühr(2009)] and present soil carbon stocks [Heim et al.(2009)]. Our Results show, that for short-term soil carbon dynamics, e.g. estimates of heterotrophic soil respiration on an annual basis, the inclusion of the dependency on litter quality is not necessary, as the differences are minor only. However, when considering long-term soil carbon dynamics, e.g. simulated estimates of present soil carbon content, the dependency on litter quality shows effect, as there are correlations with specific site factors such as site location and forest type. The inclusion of the dependence on litter quality therefore may be of importance for the projection of future soil carbon dynamics, as forest types may well be altered due to climatic change. References [Heim et al.(2009)] A. Heim, L. Wehrli, W. Eugster, and M.W.I. Schmidt. Effects of sampling design on the probability to detect soil carbon stock changes at the swiss CarboEurope site Lägeren. Geoderma, 149(3-4):347-354, 2009. [Rühr(2009)] Nadine Katrin Rühr. Soil respiration in a mixed mountain forest : environmental drivers and partitioning of component fluxes. PhD thesis, ETH, 2009. [Smith et al.(2001)] Benjamin Smith, I. Colin Prentice, and Martin T. Sykes. Representation of vegetation dynamics in the modelling of terrestrial ecosystems: comparing two contrasting approaches within european climate space. Global Ecology and Biogeography, 10(6):621-637, 2001. [Tuomi et al.(2008)] Mikko Tuomi, Pekka Vanhala, Kristiina Karhu, Hannu Fritze, and Jari Liski. Heterotrophic soil respiration-Comparison of different models describing its temperature dependence. Ecological Modelling, 211(1-2): 182-190, 2008.

  18. INTERACT-II campaign:comparison of commercial lidars and ceilometers with advanced multi-wavelength Raman lidars

    NASA Astrophysics Data System (ADS)

    Rosoldi, Marco; Madonna, Fabio; Pappalardo, Gelsomina; Vande Hey, Joshua; Zheng, Yunhui; Vaisala Team

    2017-04-01

    aim to improve the data consistency and comparability (D'Amico et al., 2016; Mattis et al., 2016). A first statistical analysis of simultaneous observations performed by all the instruments during the campaign reveals that ceilometers have fairly good performances in aerosol profiling in the lower troposphere, up to an altitude of about 2000 m above the ground, but they are limited at higher altitudes. Among the considered devices, the mini-MPL shows the best performances with discrepancies limited to 10 % throughout the troposphere. Further analysis is ongoing also to assess the stability of the considered lidar technologies with respect to variation of working and environment temperature, aerosol loading, laser operation.

  19. Association of pituitary adenylate cyclase-activating polypeptide with cognitive decline in mild cognitive impairment due to Alzheimer disease.

    PubMed

    Han, Pengcheng; Caselli, Richard J; Baxter, Leslie; Serrano, Geidy; Yin, Junxiang; Beach, Thomas G; Reiman, Eric M; Shi, Jiong

    2015-03-01

    There is a deficit of pituitary adenylate cyclase-activating polypeptide (PACAP) in patients with neuropathologically confirmed Alzheimer dementia. However, whether this deficit is associated with the earlier stages of Alzheimer disease (AD) is unknown. This study was conducted to clarify the association between PACAP biomarkers and preclinical, mild cognitive impairment (MCI), and dementia stages of AD in postmortem brain tissue. To examine PACAP and PACAP receptor levels in postmortem brain tissues and cerebrospinal fluid from cognitively and neuropathologically normal control individuals, patients with MCI due to AD (MCI-AD), and individuals with AD; analyze the relationship between PACAP, cognitive, and pathologic features; and propose a model to assess these relationships. We measured PACAP and its receptor (PAC1) levels using enzyme-linked immunoassay. A total of 35 cases were included. All the brain tissue and cerebrospinal fluid samples were selected from Banner Sun Health Research Institute Brain and Body Donation Program. All cognitive test results were in record with the Arizona Alzheimer's Consortium. A comparison of PACAP and PAC1 levels among the healthy controls, MCI-AD, and AD dementia groups, as well as a systematic correlation analysis between PACAP level, cognitive performance, and pathologic severity. The PACAP levels in cerebrospinal fluid, the superior frontal gyrus, and the middle temporal gyrus were inversely related to dementia severity. The PACAP levels in cerebrospinal fluid correlated with the Mattis Dementia Rating Scale score (Pearson r = 0.50; P = .03) and inversely correlated with total amyloid plaques (Pearson r = -0.48; P < .01) and tangles (Pearson r = -0.55; P = .01) in the brain. The PACAP in the superior frontal gyrus and middle temporal gyrus correlated with the Stroop Color-Word Interference Test (Pearson r = 0.58; P < .01) and the Auditory Verbal Learning Test-Total Learning (Pearson r = 0

  20. CBP PHASE I CODE INTEGRATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, F.; Brown, K.; Flach, G.

    The goal of the Cementitious Barriers Partnership (CBP) is to develop a reasonable and credible set of software tools to predict the structural, hydraulic, and chemical performance of cement barriers used in nuclear applications over extended time frames (greater than 100 years for operating facilities and greater than 1000 years for waste management). The simulation tools will be used to evaluate and predict the behavior of cementitious barriers used in near surface engineered waste disposal systems including waste forms, containment structures, entombments, and environmental remediation. These cementitious materials are exposed to dynamic environmental conditions that cause changes in material propertiesmore » via (i) aging, (ii) chloride attack, (iii) sulfate attack, (iv) carbonation, (v) oxidation, and (vi) primary constituent leaching. A set of state-of-the-art software tools has been selected as a starting point to capture these important aging and degradation phenomena. Integration of existing software developed by the CBP partner organizations was determined to be the quickest method of meeting the CBP goal of providing a computational tool that improves the prediction of the long-term behavior of cementitious materials. These partner codes were selected based on their maturity and ability to address the problems outlined above. The GoldSim Monte Carlo simulation program (GTG 2010a, GTG 2010b) was chosen as the code integration platform (Brown & Flach 2009b). GoldSim (current Version 10.5) is a Windows based graphical object-oriented computer program that provides a flexible environment for model development (Brown & Flach 2009b). The linking of GoldSim to external codes has previously been successfully demonstrated (Eary 2007, Mattie et al. 2007). GoldSim is capable of performing deterministic and probabilistic simulations and of modeling radioactive decay and constituent transport. As part of the CBP project, a general Dynamic Link Library (DLL

  1. Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study.

    PubMed

    Witt, Karsten; Daniels, Christine; Reiff, Julia; Krack, Paul; Volkmann, Jens; Pinsker, Markus O; Krause, Martin; Tronnier, Volker; Kloss, Manja; Schnitzler, Alfons; Wojtecki, Lars; Bötzel, Kai; Danek, Adrian; Hilker, Rüdiger; Sturm, Volker; Kupsch, Andreas; Karner, Elfriede; Deuschl, Günther

    2008-07-01

    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in patients with Parkinson's disease (PD) and improves their quality of life; however, the effect of DBS on cognitive functions and its psychiatric side-effects are still controversial. To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment. 156 patients with advanced Parkinson's disease and motor fluctuations were randomly assigned to have DBS of the STN or the best medical treatment for PD according to the German Society of Neurology guidelines. 123 patients had neuropsychological and psychiatric examinations to assess the changes between baseline and after 6 months. The primary outcome was the comparison of the effect of DBS with the best medical treatment on overall cognitive functioning (Mattis dementia rating scale). Secondary outcomes were the effects on executive function, depression, anxiety, psychiatric status, manic symptoms, and quality of life. Analysis was per protocol. The study is registered at ClinicalTrials.gov, number NCT00196911. 60 patients were randomly assigned to receive STN-DBS and 63 patients to have best medical treatment. After 6 months, impairments were seen in executive function (difference of changes [DBS-best medical treatment] in verbal fluency [semantic] -4.50 points, 95% CI -8.07 to -0.93, Cohen's d=-;0.4; verbal fluency [phonemic] -3.06 points, -5.50 to -0.62, -0.5; Stroop 2 naming colour error rate -0.37 points, -0.73 to 0.00, -0.4; Stroop 3 word reading time -5.17 s, -8.82 to -1.52, -0.5; Stroop 4 colour naming time -13.00 s, -25.12 to -0.89, -0.4), irrespective of the improvement in quality of life (difference of changes in PDQ-39 10.16 points, 5.45 to 14.87, 0.6; SF-36 physical 16.55 points, 10.89 to 22.21, 0.9; SF-36 psychological 9.74 points, 2.18 to 17.29, 0.5). Anxiety was reduced in the DBS group compared with the

  2. Integrating geology and geomorphology; the key to unlocking Quaternary tectonic framework of the San Andreas Fault zone in the San Gorgonio Pass region, southern California

    NASA Astrophysics Data System (ADS)

    Kendrick, K. J.; Matti, J. C.

    2012-12-01

    older than 500 ka, has a wide spatial footprint along a N-S axis, and Holocene alluvium is disrupted by numerous fault scarps. By contrast, south of PPB the SGPFZ consists of fewer thrust-fault strands, has a relatively narrow footprint, and faults breaking Holocene deposits are uncommon. The San Bernardino strand of the SAF intersects the SGPFZ at about the boundary between these two domains. Morphometric data indicate that the KPB has undergone significantly greater uplift than the PPB since inception of the San Bernardino strand, proposed by Matti and Morton (1993) to have occurred at ~125ka. Age estimates associated with the PPB and DGB allow us to broadly estimate relative uplift rates. Drainage reconstruction of the Whitewater River and its tributaries across the YRB likewise allow us to validate and refine the uplift estimated by Spotila and others (2001). YRB has been uplifted relative to SGB since the inception of the Mill Creek Strand of the SAF.

  3. A New Estimate for Total Offset on the Southern San Andreas Fault: Implications for Cumulative Plate Boundary Shear in the Northern Gulf of California

    NASA Astrophysics Data System (ADS)

    Darin, M. H.; Dorsey, R. J.

    2012-12-01

    Development of a consistent and balanced tectonic reconstruction for the late Cenozoic San Andreas fault (SAF) in southern California has been hindered for decades by incompatible estimates of total dextral offset based on different geologic cross-fault markers. The older estimate of 240-270 km is based on offset fluvial conglomerates of the middle Miocene Mint Canyon and Caliente Formations west of the SAF from their presumed source area in the northern Chocolate Mountains NE of the SAF (Ehlig et al., 1975; Ehlert, 2003). The second widely cited offset marker is a distinctive Triassic megaporphyritic monzogranite that has been offset 160 ± 10 km between Liebre Mountain west of the SAF and the San Bernadino Mountains (Matti and Morton, 1993). In this analysis we use existing paleocurrent data and late Miocene clockwise rotation in the eastern Transverse Ranges (ETR) to re-assess the orientation of the piercing line used in the 240 km-correlation, and present a palinspastic reconstruction that satisfies all existing geologic constraints. Our reconstruction of the Mint Canyon piercing line reduces the original estimate of 240-270 km to 195 ± 15 km of cumulative right-lateral slip on the southern SAF (sensu stricto), which is consistent with other published estimates of 185 ± 20 km based on correlative basement terranes in the Salton Trough region. Our estimate of ~195 km is consistent with the lower estimate of ~160 km on the Mojave segment because transform-parallel extension along the southwestern boundary of the ETR during transrotation produces ~25-40 km of displacement that does not affect offset markers of the Liebre/San Bernadino correlation located northwest of the ETR rotating domain. Reconciliation of these disparate estimates places an important new constraint on the total plate boundary shear that is likely accommodated in the adjacent northern Gulf of California. Global plate circuit models require ~650 km of cumulative Pacific-North America (PAC

  4. Transfer-Matrix Method for Solving the Spin 1/2 Antiferromagnetic Heisenberg Chain

    NASA Astrophysics Data System (ADS)

    Garcia-Bach, M. A.; Klein, D. J.; Valenti, R.

    Following the discovery of high Tc superconductivity in the copper oxides, there has been a great deal of interest in the RVB wave function proposed by Anderson [1]. As a warm-up exercise we have considered a valence-bond wave function for the one dimensional spin-1/2 Heisenberg chain. The main virtue of our work is to propose a new variational singlet wavefunction which is almost analytically tractable by a transfer-matrix technique. We have obtained the ground state energy for finite as well as infinite chains, in good agreement with exact results. Correlation functions, excited states, and the effects of other interactions (e.g., spin-Peierls) are also accessible within this scheme [2]. Since the ground state of the chain is known to be a singlet (Lieb & Mattis [3]), we write the appropriate wave function as a superposition of valence-bond singlets, |ψ > =∑ limits k C k | k>, where |k> is a spin configuration obtained by pairing all spins into singlet pairs, in a way which is common in valence-bond calculations of large molecules. As in that case, each configuration, |k>, can be represented by a Rümer diagram, with directed bonds connecting each pair of spins on the chain. The ck's are variational co-efficients, the form of which is determined as follows: Each singlet configuration (Rümer diagram) is divided into "zones", a "zone" corresponding to the region between two consecutive sites. Each zone is indexed by its distance from the end of the chain and by the number of bonds crossing it. Our procedure assigns a variational parameter, xij, to the jth zone, when crossed by i bonds. The resulting wavefunction for an N-site chain is written as |ψ > =∑ limits k ∏ M limits { i =1} ∏ { N -1}limits { j =1} X ij{ m ij (k)} | k> where mij(k) equals 1 when zone j is crossed by i bonds and zero otherwise. To make the calculation tractable we reduce the number of variational parameters by disallowing configurations with bonds connecting any two sites separated

  5. Feasibility of Gamified Mobile Service Aimed at Physical Activation in Young Men: Population-Based Randomized Controlled Study (MOPO).

    PubMed

    Leinonen, Anna-Maiju; Pyky, Riitta; Ahola, Riikka; Kangas, Maarit; Siirtola, Pekka; Luoto, Tim; Enwald, Heidi; Ikäheimo, Tiina M; Röning, Juha; Keinänen-Kiukaanniemi, Sirkka; Mäntysaari, Matti; Korpelainen, Raija; Jämsä, Timo

    2017-10-10

    fitness from baseline between the groups, whereas waist circumference was reduced in the most inactive men within the intervention group (P=.01). Among completers with valid physical activity data (n=167), there was a borderline difference in the change in mean daily time spent in moderate to vigorous physical activity between the groups (11.9 min vs -9.1 min, P=.055, linear mixed model). Within the intervention group (n=87), baseline vigorous physical activity was inversely associated with change in moderate to vigorous physical activity during the trial (R=-.382, P=.01). The various functionalities related to physical activity of the gamified tailored mobile service were considered important. However, the compliance was limited. Within the current setup, the mobile service had no effect on anthropometry or fitness, except reduced waist circumference in the most inactive men. Among completers with valid physical activity data, the trial had a borderline positive effect on moderate to vigorous physical activity. Further development is needed to improve the feasibility and adherence of an integrated multifunctional service. Clinicaltrials.gov NCT01376986; http://clinicaltrials.gov/ct2/show/NCT01376986 (Archived by WebCite at http://www.webcitation.org/6tjdmIroA). ©Anna-Maiju Leinonen, Riitta Pyky, Riikka Ahola, Maarit Kangas, Pekka Siirtola, Tim Luoto, Heidi Enwald, Tiina M Ikäheimo, Juha Röning, Sirkka Keinänen-Kiukaanniemi, Matti Mäntysaari, Raija Korpelainen, Timo Jämsä. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 10.10.2017.

  6. Does the West Salton Detachment extend through San Gorgonio Pass, southern California?

    NASA Astrophysics Data System (ADS)

    Matti, J. C.; Langenheim, V. E.

    2008-12-01

    Rift-related extension and low-angle crustal detachment are key structural elements of the late Cenozoic southern San Andreas Fault system, as manifested by the West Salton Detachment (WSD). The most northwestern exposure of the WSD is in the Santa Rosa Mts (SRM), where the Zosel Fault bottoms a hangingwall sequence of upper Cenozoic marine and terrestrial sedimentary deposits that include stratigraphic units well known throughout the Salton Trough region. We have used geologic and geophysical data to investigate the distribution of the WSD system in the northern Salton Trough, including its possible extension into and beyond San Gorgonio Pass. Although the WSD is not exposed north of the SRM, late Miocene marine and terrigenous sedimentary rocks at Garnet Hill probably are hangingwall deposits squeezed up within the San Andreas Fault zone. West of Garnet Hill lie San Gorgonio Pass (SGP) and the 3 km-high northern escarpment of the San Jacinto Mountains (SJM). In SGP, upper Cenozoic sedimentary rocks south of the Banning strand of the San Gabriel Fault include the marine Imperial Formation and associated terrestrial deposits, a sequence similar to that in the WSD hangingwall throughout the greater Salton Trough region. We propose that the WSD originally extended from the NW head of Coachella Valley west into SGP, where the detachment may form the base of the Cenozoic marine and terrestrial sedimentary sequence. The WSD probably continues west beyond SGP, with extensional translation decreasing until the detachment intersects the Banning Fault near Calimesa. There, we propose that the WSD underlies a subsurface sedimentary package north of the San Timoteo badlands and south of the Banning Fault that a gravity low suggests is 2 km thick, and that reportedly contains marine sediment penetrated in boreholes. When ~44 km of right-slip is restored on the Banning Fault (Matti and Morton, 1993), the Calimesa low restores opposite a similar low in the northwestern Coachella

  7. Fragmented Landscapes in the San Gorgonio Pass Region: Insights into Quaternary Strain History of the Southern San Andreas Fault System

    NASA Astrophysics Data System (ADS)

    Kendrick, K. J.; Matti, J. C.; Landis, G. P.; Alvarez, R. M.

    2006-12-01

    The San Gorgonio Pass (SGP) region is a zone of structural complexity within the southern San Andreas Fault system that is characterized by (1) multiple strands of the San Andreas Fault (SAF), (2) intense and diverse microseismicity, (3) contraction within the SGP fault zone (SGPfz), and (4) complex and diverse landforms - all a consequence of structural complications in the vicinity of the southeastern San Bernardino Mountains (SBM). Multiple strands of the SAF zone in the SGP region partition the landscape into discrete geomorphic/geologic domains, including: San Gorgonio Mountain (SGM), Yucaipa Ridge (YR), Kitching Peak (KP), Pisgah Peak (PP), and Coachella Valley (CV) domains. The morphology of each domain reflects the tectonic history unique to that region. Development of the SGP knot in the Mission Creek strand of the SAF (SAFmi) led to westward deflection of the SAFmi, juxtaposition of the KP, PP, and SGM domains, initiation of uplift of YR domain along thrust faults in headwaters of San Gorgonio River, and development of the San Jacinto Fault. Slip on the SAF diminished as a result, thereby allowing integrated drainage systems to develop in the greater SGP region. San Gorgonio River, Whitewater River, and Mission Creek are discrete drainages that transport sediment across the SGM, YR, PP, KP, and CV domains into alluvial systems peripheral to the SGP region. There, depositional units (San Timoteo Formation, upper member, deformed gravels of Whitewater River) all contain clasts of SBM-type and San Gabriel Mountain-type basement, thus constraining slip on the SAF in the SGP region. Middle and late Pleistocene slip on the Mill Creek strand of the SAF (SAFm) in the SGP region has attempted to bypass the SGP knot, and has disrupted landscapes established during SAFmi quiescence. Restoration of right-slip on the SAFm is key to deciphering landscape history. Matti and others (1985, 1992) proposed that a bi-lobed alluvial deposit in the Raywood Flats area has been

  8. EDITORIAL: 'Best article' prize for the 5th anniversary of Environmental Research Letters 'Best article' prize for the 5th anniversary of Environmental Research Letters

    NASA Astrophysics Data System (ADS)

    Kammen, Dan; Wright, Guillaume

    2011-12-01

    To celebrate the 5th anniversary of Environmental Research Letters (ERL) the publishers of the journal, IOP Publishing, have awarded a prize for the five best articles published in ERL since the journal began in 2006. The procedure for deciding the winning articles was as thorough as possible to ensure that the most outstanding articles would win the prize. A shortlist of 25 nominated research articles, five for each year since ERL was launched, which were chosen based on a range of criteria including novelty, scientific impact, readership, broad appeal and wider media coverage, was selected. The ERL Editorial Board then assessed and rated these 25 articles in order to choose a winning article for each year. We would like to announce that the following articles have been awarded ERL's 5th anniversary best article prize: 2006/7 The Bodélé depression: a single spot in the Sahara that provides most of the mineral dust to the Amazon forest Ilan Koren, Yoram J Kaufman, Richard Washington, Martin C Todd, Yinon Rudich, J Vanderlei Martins and Daniel Rosenfeld 2006 Environ. Res. Lett. 1 014005 2008 Causes and impacts of the 2005 Amazon drought Ning Zeng, Jin-Ho Yoon, Jose A Marengo, Ajit Subramaniam, Carlos A Nobre, Annarita Mariotti and J David Neelin 2008 Environ. Res. Lett. 3 014002 2009 How difficult is it to recover from dangerous levels of global warming? J A Lowe, C Huntingford, S C B Raper, C D Jones, S K Liddicoat and L K Gohar 2009 Environ. Res. Lett. 4 014012 2010 Is physical water scarcity a new phenomenon? Global assessment of water shortage over the last two millennia Matti Kummu, Philip J Ward, Hans de Moel and Olli Varis 2010 Environ. Res. Lett. 5 034006 2011 Implications of urban structure on carbon consumption in metropolitan areas Jukka Heinonen and Seppo Junnila 2011 Environ. Res. Lett. 6 014018 Our congratulations go to these authors. In recognition of their outstanding work, we are delighted to offer all of the authors of the winning articles free

  9. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Lidström, Suzanne

    2012-04-01

    , in his hands, the expansion continued and the transition to electronic production took place. In 2005, an agreement was signed with IOP Publishing and the bustling production work of the in-house team moved abroad to Bristol, leaving just the Editor-in-Chief to man the ship at the Royal Swedish Academy of Sciences. In 2011, however, as Roger prepared to step down, submissions had reached astounding levels as is evident from figure 1: that year, almost 1500 manuscripts were received by Physica Scripta, now acknowledged to be amongst the fastest growing journals in IOP Publishing, when measured in these terms. The year on year increase stands at 20% and, once again, of the extensive range of topics covered, condensed matter physics had been identified as the subject area in most need of attention because the burden of reviewing had become too great for one editor to oversee alone. Thus, when I joined Physica Scripta in January of this year, securing new External Editors for this field was perceived to be the most urgent task. It is, therefore, with the greatest of pleasure that I am able to announce the arrival of two new editors for this section: Professors David Keen and Tapio Rantala. Physica Scripta statistics Figure 1. The annual submissions made to Physica Scripta in recent years have rocketed and the rejection rate (given as a percentage) has increased rapidly. The modest increase in the number of articles accepted (shaded in blue) reflects a deliberate policy to augment the scientific quality. Professor Rantala has been selected by the Finnish Physical Society to replace Professor Matti Manninen, who is stepping down as the Finnish representative on the journal's Editorial Board. Professor Rantala is a prominent theorist and has been engaged in active research in a number of fields. In his early work, he was interested in surface science and molecular physics, however his expertise is predominantly in the domain of solid or materials physics related to

  10. EDITORIAL: Focus on Cloaking and Transformation Optics

    NASA Astrophysics Data System (ADS)

    Leonhardt, Ulf; Smith, David R.

    2008-11-01

    multi-frequency cloaking Andrea Alù and Nader Engheta Electromagnetic cloaking devices for TE and TM polarizations Filiberto Bilotti, Simone Tricarico and Lucio Vegni An aberration-free lens with zero F-number D Schurig Transformational optics of plasmonic metamaterials I I Smolyaninov An acoustic metafluid: realizing a broadband acoustic cloak J B Pendry and Jensen Li On the possibility of metamaterial properties in spin plasmas G Brodin and M Marklund A homogenization route towards square cylindrical acoustic cloaks Mohamed Farhat, Sébastien Guenneau, Stefan Enoch, Alexander Movchan, Frédéric Zolla and André Nicolet Transformation optics: approaching broadband electromagnetic cloaking A V Kildishev, W Cai, U K Chettiar and V M Shalaev Generalized field-transforming metamaterials Sergei A Tretyakov, Igor S Nefedov and Pekka Alitalo Electromagnetic beam modulation through transformation optical structures Xiaofei Xu, Yijun Feng and Tian Jiang Superantenna made of transformation media Ulf Leonhardt and Tomáš Tyc Material parameters and vector scaling in transformation acoustics Steven A Cummer, Marco Rahm and David Schurig Isotropic transformation optics: approximate acoustic and quantum cloaking Allan Greenleaf, Yaroslav Kurylev, Matti Lassas and Gunther Uhlmann Transformation optical designs for wave collimators, flat lenses and right-angle bends Do-Hoon Kwon and Douglas H Werner Alternative derivation of electromagnetic cloaks and concentrators A D Yaghjian and S Maci Solutions in folded geometries, and associated cloaking due to anomalous resonance Graeme W Milton, Nicolae-Alexandru P Nicorovici, Ross C McPhedran, Kirill Cherednichenko and Zubin Jacob Finite wavelength cloaking by plasmonic resonance N-A P Nicorovici, R C McPhedran, S Enoch and G Tayeb

  11. Obituary: Frank Culver Jones, 1932-2007

    NASA Astrophysics Data System (ADS)

    Ormes, Johnathan F.; Streitmatter, Robert E.

    2007-12-01

    everyone from technicians to scientists and managers. This generosity resulted in his becoming the first senior research scientist to be honored with the Laboratory's Peer Award. Survivors include his wife of 52 years, Ardythe Grube Jones of Silver Spring, Maryland, two children, Cheryl Mattis of Columbia and Timothy Jones of Silver Spring, two brothers, and four grandchildren.

  12. News and Announcements

    NASA Astrophysics Data System (ADS)

    1999-05-01

    Supplementary Materials The number of supplementary materials that accompany print articles has grown and also become more varied. The new guidelines for lab experiments call for supplementary materials in most cases, so that the actual materials used in lab can be made available. The From Past Issues column edited by Kathryn Williams and many of the technology columns frequently have supplements for JCE Online. An especially interesting supplement that we would like to call to the attention of readers is a collection of videos from the E. O. Lawrence Berkeley National Laboratory, based on interviews with nuclear chemists who have discovered and studied the heaviest elements. These movies accompany the Viewpoints article, "Chemistry of the Heaviest Elements-One Atom at a Time" by Darleane C. Hoffman and Diana M. Lee. The titles of the movies are listed below; illustrative stills are shown at the bottom of the page. Researchers involved with the segments about Lawrencium include Robert Silva, Torbjorn Sikkeland, Matti Nurmia, Robert Latimer, and Albert Ghiorso, all of whom are from the Lawrence Berkeley Laboratory. (QuickTime 3 is needed in order to view the videos; it can be downloaded free from http://www.apple.com.)

    • A Brief Note about Plutonium, by Glenn Seaborg
    • Plutonium and Why It Was Kept a Secret
    • The Prediction of the Actinide Series, by Glenn Seaborg
    • First Chemical Separation of Lawrencium at Lawrence Radiation Laboratory in 1970
    • The HILAC or Heavy-Ion Linear Accelerator
    • Discovery of Lawrencium
    • How To Collect Lawrencium Atoms
    • The Discovery of Element 106-Finally
    • The Naming of Element 106
    • The Limits of Discovering the Heavy Elements
    • What Good Is a Heavy Element?
    To see these videos, view the Supplements of http://JChemEd.chem.wisc.edu/Journal/Issues/1999/Mar/abs331.html. People: Glenn Seaborg Glenn Seaborg, frequent contributor

  13. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    NASA Astrophysics Data System (ADS)

    Suominen, Kalle-Antti

    2010-09-01

    information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

  14. EDITORIAL: Special issue on optical neural engineering: advances in optical stimulation technology Special issue on optical neural engineering: advances in optical stimulation technology

    NASA Astrophysics Data System (ADS)

    Shoham, Shy; Deisseroth, Karl

    2010-08-01

    C, Mattis J, Prakash R, Diester I, Goshen I, Thompson K R, Deisseroth K 2010 Molecular and cellular approaches for diversifying and extending optogenetics Cell 141 154-65 [18] Zhang F, Gradinaru V, Adamantidis A R, Durand R, Airan R D, de Lecea L and Deisseroth K 2010 Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures Nat. Protoc. 5 439-56 [19] Wells J, Kao C, Mariappan K, Albea J, Duco Jansen E, Konrad P and Mahadevan-Jansen A 2005 Optical stimulation of neural tissue in vivo Opt. Lett. 30 504-6 [20] Izzo A D, Richter C P, Jansen E D and Walsh J T Jr 2006 Laser stimulation of the auditory nerve Lasers Surg. Med. 38 745-53 [21] Richter C P, Izzo A D, Wells J, Jansen E D and Walsh J T Jr 2010 Neural stimulation with optical radiation Laser Photonics Rev. available at doi:10.1002/lpor.200900044 [22] Nikolenko V, Peterka D S and Yuste R 2010 A portable laser photostimulation and imaging microscope J. Neural Eng. 7 045001 [23] Golan L, Reutsky I, Farah N and Shoham S 2009 Design and characteristics of holographic neural photo-stimulation systems J. Neural Eng. 6 066004 [24] Losavio B E, Iyer V, Patel S and Saggau P 2010 Acousto-optical laser scanning for multi-site photo-stimulation of single neurons in vitro J. Neural Eng. 7 045002 [25] Duemani Reddy G, Kelleher K, Fink R and Saggau P 2008 Three-dimensional random access multiphoton microscopy for functional imaging of neuronal activity Nat. Neurosci. 11 713-20 [26] Grewe B F, Langer D, Kasper H, Kampa B M and Helmchen F 2010 High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision Nat. Methods 7 399-405 [27] Pikov V, Arakaki X, Harrington M, Fraser S E and Siegel P H 2010 Modulation of neuronal activity and plasma membrane propertiess with low-power millimeter waves in organotypic cortical slices J. Neural Eng. 7 045003 [28] Liang S et al 2009 Temperature-dependent activation of neurons by continuous near-infrared laser Cell

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