Behavior of sandhill cranes harnessed with different satellite transmitters

USGS Publications Warehouse

Olsen, Glenn H.; Ellis, D.H.; Landfried, S.E.; Miller, L.H.; Klugman, S.S.; Fuller, M.R.; Vermillion, C.H.

1992-01-01

The effectiveness of various attachment methods and designs of platform transmitting terminals (PTT's) was tested on captive sandhill cranes (Grus canadensis) at the Patuxent Wildlife Research Center, Laurel, Maryland, during 1989-91. Combinations of attachment and transmitter designs included neoprene cord harness with batteries separate from the transmitter (2 harness designs), Teflon ribbon harness with batteries incorporated into the transmitter package (4 transmitter models), and a package attached directly to the bird with epoxy glue only. Physical effects seen on cranes wearing PTT's ranged from skin lacerations (caused by rubbing of harness material) to no observed effects (other than feather wear). The most successful harness material and design utilized a Teflon ribbon harness with the 4 ribbon ends from the transmitter forming a neck loop and a body loop joined at the sternum. Time spent by sandhill cranes performing most activities did not change after transmitter attachment using this harness method.

On-Orbit Evaluation of a New Treadmill Harness for Improved Crewmember Comfort and Load Distribution

NASA Technical Reports Server (NTRS)

Perusek, G. P.; Sheehan, C. C.; Savina, M. C.; Owings, T. M.; Davis, B. L.; Ryder, J. W.

2011-01-01

The current design of the International Space Station (ISS) Treadmill Harness has been reported to cause pain and discomfort to crewmembers during exercise. The Harness Station Development Test Objective (SDTO) provided participating crewmembers (n = 6) with a new harness design, the "Glenn Harness," to evaluate for comfort and loading as compared to the current Treadmill Harness. A novel suite of load-sensing instrumentation was developed to noninvasively measure load distribution and provided a first-ever quantification of actual dynamic loads during treadmill exercise. In addition, crew debriefs provided feedback on harness preference and overall impressions. Conclusions: Post-flight analysis in returned Glenn Harnesses (n = 3) showed minimal wear and tear. Four of the six subjects found the Glenn Harness to be more comfortable in this on-orbit, side-by-side comparison as measured by the crew comfort questionnaire and crew debriefs. Specific areas for improvement have been identified, and forward recommendations will be provided to the Human Research Program. The protocol developed for the SDTO provided valuable insight into crew comfort issues, design improvements, and loading preferences for exercise harnessing, which lays the groundwork for better harnessing systems and training protocols.

Structural changes and out-of-sample prediction of realized range-based variance in the stock market

NASA Astrophysics Data System (ADS)

Gong, Xu; Lin, Boqiang

2018-03-01

This paper aims to examine the effects of structural changes on forecasting the realized range-based variance in the stock market. Considering structural changes in variance in the stock market, we develop the HAR-RRV-SC model on the basis of the HAR-RRV model. Subsequently, the HAR-RRV and HAR-RRV-SC models are used to forecast the realized range-based variance of S&P 500 Index. We find that there are many structural changes in variance in the U.S. stock market, and the period after the financial crisis contains more structural change points than the period before the financial crisis. The out-of-sample results show that the HAR-RRV-SC model significantly outperforms the HAR-BV model when they are employed to forecast the 1-day, 1-week, and 1-month realized range-based variances, which means that structural changes can improve out-of-sample prediction of realized range-based variance. The out-of-sample results remain robust across the alternative rolling fixed-window, the alternative threshold value in ICSS algorithm, and the alternative benchmark models. More importantly, we believe that considering structural changes can help improve the out-of-sample performances of most of other existing HAR-RRV-type models in addition to the models used in this paper.

Manufacturing and quality control of interconnecting wire harnesses, Volume 4

NASA Technical Reports Server (NTRS)

1972-01-01

The document covers interconnecting wire harnesses defined in the design standard, including type 8, flat conductor cable. Volume breadth covers installations of groups of harnesses in a major assembly and the associated post installation inspections and electrical tests. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into this document.

Embedding human annoyance rate models in wireless smart sensors for assessing the influence of subway train-induced ambient vibration

NASA Astrophysics Data System (ADS)

Sun, Ke; Zhang, Wei; Ding, Huaping; Kim, Robin E.; Spencer, Billie F., Jr.

2016-10-01

The operation of subway trains induces ambient vibrations, which may cause annoyance and other adverse effects on humans, eventually leading to physical, physiological, and psychological problems. In this paper, the human annoyance rate (HAR) models, used to assess the human comfort under the subway train-induced ambient vibrations, were deduced and the calibration curves for 5 typical use circumstances were addressed. An autonomous measurement system, based on the Imote2, wireless smart sensor (WSS) platform, plus the SHM-H, high-sensitivity accelerometer board, was developed for the HAR assessment. The calibration curves were digitized and embedded in the computational core of the WSS unit. Experimental validation was conducted, using the developed system on a large underground reinforced concrete frame structure adjoining the subway station. The ambient acceleration of both basement floors was measured; the embedded computation was implemented and the HAR assessment results were wirelessly transmitted to the central server, all by the WSS unit. The HAR distributions of the testing areas were identified, and the extent to which both basements will be influenced by the close-up subway-train’s operation, in term of the 5 typical use circumstances, were quantitatively assessed. The potential of the WSS-based autonomous system for the fast environment impact assessment of the subway train-induced ambient vibration was well demonstrated.

Effects of Caudal Elevation on Testicular Function in Rats: Separation of Effects on Spermatogenesis and Steroidogenesis

NASA Technical Reports Server (NTRS)

Deaver, D. R.; Amann, R. P.; Hammerstedt, R. H.; Ball, R.; Veeramachaneni, D. N. R.; Musacchia, X. J.

1992-01-01

A variety of biologic processes are perturbed when exposed to microgravity (space flight) for more than 7 days, including testicular function. Suspension of rats in a special harness (caudal elevation) to induce thoracic pooling of blood fluids and remove the support function of the hind limbs is used to mimic, on earth, the effects of microgravity encountered during space flight. Typically, this induces cryptorchidism in male rats. Three experiments were conducted to differentiate the effects of caudal elevation (30 deg angle) and anatomic location of testes on spermatogenesis and steroidogenesis. Rats were subjected to caudal elevation for 7 days using either a tail harness or a whole-body harness. Testes of rats fell into the abdominal cavity when a tail harness was used, but ligation of the iguinal canal prevented this repositioning. For rats with abdominal testes, testicular weight was reduced (P less than 0.05) and histology of testes was abnormal; the number of spermatids per gram parenchyma was lower (P less than 0.05) in tail-suspended rats compared with control rats.

High-Density Terminal Box for Testing Wire Harness

NASA Technical Reports Server (NTRS)

Pierce, W. B.; Collins, W. G.

1982-01-01

Compact terminal box provides access to complex wiring harnesses for testing. Box accommodates more than twice as many wires as previous boxes. Box takes in wires via cable connectors and distributes them to contacts on box face. Instead of separate insulated jacks in metal face panel, box uses pairs of small military-standard metal sockets in precision-drilled plastic panel. Shorting plug provides continuity for wires when not being tested.

42 CFR 84.151 - Harness test; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... concrete floor without disarranging the harness or exerting a pull on the facepiece. (5) The arrangement... manner that prevents a pull equivalent to dragging the maximum length of the hose over a concrete floor...

Cable tester

NASA Astrophysics Data System (ADS)

Rammage, Robert L.

1990-10-01

A device for sequentially testing the plurality of connectors in a wiring harness is disclosed. The harness is attached to the tester by means of adapter cables and a rotary switch is used to sequentially, individually test the connectors by passing a current through the connector. If the connector is unbroken, a light will flash to show it is electrically sound. The adapters allow a large number of cable configurations to be tested using a single tester configuration.

Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models.

PubMed

Moore, Holly; Geyer, Mark A; Carter, Cameron S; Barch, Deanna M

2013-11-01

Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. Copyright © 2013. Published by Elsevier Ltd.

Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models

PubMed Central

Moore, Holly; Geyer, Mark A.; Carter, Cameron S.; Barch, Deanna M.

2014-01-01

Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. PMID:24090823

vvtools v. 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drake, Richard R.

Vvtools is a suite of testing tools, with a focus on reproducible verification and validation. They are written in pure Python, and contain a test harness and an automated process management tool. Users of vvtools can develop suites of verification and validation tests and run them on small to large high performance computing resources in an automated and reproducible way. The test harness enables complex processes to be performed in each test and even supports a one-level parent/child dependency between tests. It includes a built in capability to manage workloads requiring multiple processors and platforms that use batch queueing systems.

Using Civilization IV to Engage Students in World History Content

ERIC Educational Resources Information Center

Pagnotti, John; Russell, William B., III

2012-01-01

How can teachers utilize video games in the classroom, harnessing a technology that is gaining "market share" in the lives of our students? This article will provide classroom teachers with a research-based rationale for using video games along with a viable, classroom-tested lesson to teach social studies content using a widely…

Perspectives on the Integration of Technology and Assessment

ERIC Educational Resources Information Center

Pellegrino, James W.; Quellmalz, Edys S.

2011-01-01

This paper considers uses of technology in educational assessment from the perspective of innovation and support for teaching and learning. It examines assessment cases drawn from contexts that include large-scale testing programs as well as classroom-based programs, and attempts that have been made to harness the power of technology to provide…

The X-40A immediately after release from its harness suspended from a helicopter 15,000 feet above NASA's Dryden Flight Research Center at Edwards Air Force Base, California, on March 14, 2001

NASA Image and Video Library

2001-03-14

The X-40A immediately after release from its harness suspended from a helicopter 15,000 feet above NASA's Dryden Flight Research Center at Edwards Air Force Base, California, on March 14, 2001. The unpiloted X-40 is a risk-reduction vehicle for the X-37, which is intended to be a reusable space vehicle. NASA's Marshall Space Flight Center in Huntsville, Ala, manages the X-37 project. At Dryden, the X-40A will undergo a series of ground and air tests to reduce possible risks to the larger X-37, including drop tests from a helicopter to check guidance and navigation systems planned for use in the X-37. The X-37 is designed to demonstrate technologies in the orbital and reentry environments for next-generation reusable launch vehicles that will increase both safety and reliability, while reducing launch costs from $10,000 per pound to $1,000 per pound.

A home-based body weight supported treadmill training program for children with cerebral palsy: A case series.

PubMed

Kenyon, Lisa K; Westman, Marci; Hefferan, Ashley; McCrary, Peter; Baker, Barbara J

2017-07-01

Contemporary approaches to the treatment of cerebral palsy (CP) advocate a task-specific approach that emphasizes repetition and practice of specific tasks. Recent studies suggest that body-weight-supported treadmill training (BWSTT) programs may be beneficial in clinical settings. The purposes of this case series were to explore the outcomes and feasibility of a home-based BWSTT program for three children with CP. Three children with CP at Gross Motor Function Classification System (GMFCS) Levels III or IV participated in this case series. Examination included the Functional Assessment Questionnaire (FAQ), the 10-meter walk test, the Gross Motor Function Measure (GMFM-66), and the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT). A harness system was used to conduct the BWSTT program over an 8-12 week period. All of the families reported enjoying the BWSTT program and found the harness easy to use. Participant 2 increased from a 2 to a 4 on the FAQ, while Participant 3 increased from a 6 to a 7. Two of the participants demonstrated post-intervention improvements in functional mobility. In addition to mobility outcomes, future research should explore the potential health benefits of a home-based BWSTT program.

Are we ignoring neutral and negative human-animal relationships in zoos?

PubMed

Hosey, Geoff; Melfi, Vicky

2015-01-01

Human-animal interactions (HAI), which may lead to human-animal relationships (HAR), may be positive, neutral, or negative in nature. Zoo studies show that visitors may be stressful, may have no effect, or may be enriching. There is also evidence that good HARs set up between animals and their keepers can have positive effects on animal welfare. However, we need to know more about negative HARs, and as a first step we attempt to do this here by considering cases where animals attack people in the zoo. Due to the sensitivity and rarity of these events data appear sparse and unsystematically collected. Here, information available in the public domain about the circumstances of these attacks has been collated to test hypotheses about negative HAIs derived from a model of zoo HARs. The limited data presented here broadly support the zoo HAR model, and suggest that attacks usually happen in unusual circumstances, where there may be a failure by the animal to recognise the HAR, or where the relationship, if there is one, does not hold; and give some support to the prediction that exposure to many keepers may impair the development of a positive HAR. This study may provide useful information for the zoo community to proactively collect systematic standardised records, which will enable a fuller understanding of zoo HARs, upon which appropriate measures might be adopted to build better zoo HARs, which are likely to positively impact zoo animal welfare, and reduce these rare incidences further. © 2014 Wiley Periodicals, Inc.

Application of a modified harness design for attachment of radio transmitters to shorebirds

USGS Publications Warehouse

Sanzenbacher, Peter M.; Haig, Susan M.; Oring, Lewis W.

2000-01-01

Radio transmitter attachment methodology is important to the design of radio telemetry studies. In 1998, we attached 5 transmitters to a captive population of Western Sandpipers (Calidris mauri) and 7 transmitters to wild Killdeer (Charadriusv ociferus) using a modified version of the Rappole and Tipton (1991) figure-8 leg-loop harness. Captive birds fitted with harnesses did not exhibit quantifiable differences in behavior relative to control birds. Based on initial success in using the leg-loop harnesses, we used harnesses to attach transmitters in the wild to 30 Killdeer and 49 Dunlin (Calidris alpina) during the winters of 1998-1999 and 1999-2000. This was part of a study on movements of wintering shorebirds in the Willamette Valley of Oregon, USA. Wild birds showed no adverse effects of the harnesses.Thus, the described harness is a practical method for attachment of transmitters to shorebirds. Advantages of this harness method include a reduction in handling time at capture, elimination of the need to clip feathers for attachment, and increased transmitter retention time.

Usability issues concerning child restraint system harness design.

PubMed

Rudin-Brown, Christina M; Kumagai, Jason K; Angel, Harry A; Iwasa-Madge, Kim M; Noy, Y Ian

2003-05-01

A study was conducted to assess usability issues relating to child restraint system (CRS) harness design. Four convertible child restraint systems representing a wide variety of design features were used. Forty-two participants installed two child test dummies in both forward- and rear-facing configurations either inside or outside a test vehicle. Observer-scored checklists determined the degree to which each harness was installed correctly. Participant-scored questionnaires evaluated the 'ease-of-use' of various design features. While the percentage of correct installations exceeded 83% for all designs when installed in the forward-facing configuration, in the rear-facing position (that intended for children under 9-10 kg), there was a significant (between 65 and 89%) percentage of incorrect installations for all models. This finding is of particular interest and may be indicative of a more generalized problem with 'convertible' CRS designs when they are used in the rear-facing configuration. Furthermore, while certain design features were perceived by users as providing significantly better protection in the event of a collision, these also tended to be the features that were misused most often. The benefits and costs of various design features are discussed, and a method to test harness design usability is presented.

Effects of radio transmitters on migrating wood thrushes

USGS Publications Warehouse

Powell, L.A.; Krementz, D.G.; Lang, J.D.; Conroy, M.J.

1998-01-01

We quantified the effects of radio transmitters on Wood Thrushes (Hylocichla mustelina) using 4 yr of banding and telemetry data from Piedmont National Wildlife Refuge, Georgia. Flight performance models suggest that the 1.6-g transmitter shortens the migratory range of Wood Thrushes by only 60 km, and the estimated migratory range is adequate to accomplish migration even with limited fat stores. We used two strengths of line, 5- and 9-kg test-strength braided Dacron, to attach the transmitters using the thigh-harness method. We recaptured 13 returning radio-marked Wood Thrushes, seven of which were still marked. Six of the seven birds marked with the 5-kg test harnesses lost their transmitters within 1 yr while all six of the 9-kg test harnesses were still attached up to 21 mo later. Radio-marking did not reduce the return rates of adults and immatures, and the transmitters did not cause radio-marked birds to lose more mass than banded-only birds. Wood Thrushes can successfully carry a transmitter during migration with no detectable negative effects. We recommend continued use of the thigh-harness method, but we encourage the use of 5-kg cotton line.

Reliability in fiber optic cable harness manufacturing

NASA Astrophysics Data System (ADS)

McCoy, Bruce M.

Key aspects of manufacturing cable harnesses for aircraft and spacecraft that incorporate optical fiber/cables along with traditional wiring are discussed. Issues regarding feasibility of automation of assembly processes, manual assembly, testing, installation, quality assurance, reliability and maintainability are addressed. Training procedures, formal training programs, and their results are reviewed.

Managing Uncertainty and Risk in Public-sector Investments

DTIC Science & Technology

2007-04-30

parameters with the most predictive power. There are, of course , methods other than market-based Capital Asset Pricing for determining asset...harness new information as it becomes available. For private-sector firms, prices provide two important types of information: 1. The rate at which...based valuation, thus providing a basis for testing the validity of using the internal efficiencies to derive a “synthetic price” for the value of a

Heat radiation approach for harnessing heat of the cook stove to generate electricity for lighting system and charging of mobile phone

NASA Astrophysics Data System (ADS)

Muñoz, Rodrigo C., Jr.; Manansala, Chad Deo G.

2018-01-01

This study is based on the potential of thermoelectric coupling such as the thermoelectric cooler module. A thermoelectric cooler converts the heat coming from the cook stove into electricity and store in a battery. A dc-dc boost converter will be used to produce enough voltage to light a minimum house dwelling or charge phone battery. This device will be helpful to those that faces a problem on electricity especially in the isolated areas. The study aims (1) to harness heat from the cook stove up to 110 °C (2) To automatically cool-off the system to protect the thermoelectric cooler from damage due to excessive heat using an electronic solenoid; (3) To store energy harnessed in the battery; (4) To amplify the output voltages of the battery using DC to DC boost converter for lighting system and charging of mobile phone battery. From various tests conducted, it can fully charge a mobile phone in 3 hours observing the unit’s battery voltage drop from 4.06V to 3.98V. In the testing it used different orientation of steel rod by conduction to transfer heat and by radiation through tubular steel with its different dimensions. Most recent testing proved that the 2x2x9 tubular steel by radiation had the best result. The temperature reached more than a hundred degree Celsius that met the objective. The test resulted of boosting the voltage of the battery output from 3.7V to 4.96V on the average. The boosted voltage decrease as the system’s cool-off mechanism operated when the temperature reached above 110 degree Celsius decreasing output voltage to 0.8V resulting the boosted voltage to drop to zero. Therefore, the proponents concluded that heat waste can be converted to electrical energy by harnessing heat through radiation, with the help of TEC that generates voltage for lighting and can be boosted to be used for mobile charging. Furthermore, the study proved that the excess heat can damaged the TEC which was prevented by using of cooling-off mechanism, making it more useful for longer time.

Projectile Impact Effects on Aircraft Wire Harnesses

DTIC Science & Technology

1986-01-08

circuits Aircraft wire harnesses Modified ETFE Projectile damage and fires 19 ABSTRACT (Continue on reverse if necessary and identit) by block number...Tile Firifinr~ari~ne An overview of tile test fiririý raný,e is shown in Figure b. In tile for-eyrouria is tre rifle, witzh stock removed, utor iuyo e

Hirshfeld atom refinement for modelling strong hydrogen bonds.

PubMed

Woińska, Magdalena; Jayatilaka, Dylan; Spackman, Mark A; Edwards, Alison J; Dominiak, Paulina M; Woźniak, Krzysztof; Nishibori, Eiji; Sugimoto, Kunihisa; Grabowsky, Simon

2014-09-01

High-resolution low-temperature synchrotron X-ray diffraction data of the salt L-phenylalaninium hydrogen maleate are used to test the new automated iterative Hirshfeld atom refinement (HAR) procedure for the modelling of strong hydrogen bonds. The HAR models used present the first examples of Z' > 1 treatments in the framework of wavefunction-based refinement methods. L-Phenylalaninium hydrogen maleate exhibits several hydrogen bonds in its crystal structure, of which the shortest and the most challenging to model is the O-H...O intramolecular hydrogen bond present in the hydrogen maleate anion (O...O distance is about 2.41 Å). In particular, the reconstruction of the electron density in the hydrogen maleate moiety and the determination of hydrogen-atom properties [positions, bond distances and anisotropic displacement parameters (ADPs)] are the focus of the study. For comparison to the HAR results, different spherical (independent atom model, IAM) and aspherical (free multipole model, MM; transferable aspherical atom model, TAAM) X-ray refinement techniques as well as results from a low-temperature neutron-diffraction experiment are employed. Hydrogen-atom ADPs are furthermore compared to those derived from a TLS/rigid-body (SHADE) treatment of the X-ray structures. The reference neutron-diffraction experiment reveals a truly symmetric hydrogen bond in the hydrogen maleate anion. Only with HAR is it possible to freely refine hydrogen-atom positions and ADPs from the X-ray data, which leads to the best electron-density model and the closest agreement with the structural parameters derived from the neutron-diffraction experiment, e.g. the symmetric hydrogen position can be reproduced. The multipole-based refinement techniques (MM and TAAM) yield slightly asymmetric positions, whereas the IAM yields a significantly asymmetric position.

Effects of backpack radiotags on female northern pintails wintering in California

USGS Publications Warehouse

Fleskes, Joseph P.

2003-01-01

To test whether backpack radiotags impacted the wintering biology of northern pintails (Anas acuta), I attached spear-suture (SSU, n=82 in 1993) or harness (HAR, n=337 in 1991-1993) backpack radiotags to female Hatch-Year (HY) and After-Hatch-Year (AHY) pintails after their autumn arrival in California. I evaluated impacts of radiotags on 1) wintering population distribution; 2) flock status, flock size, and body mass at harvest; and 3) August-March survival. I also compared retention of SSU and HAR following attachment. Distribution, flock status, and flock size at harvest of HAR, SSU, and unmarked (UMK) pintails were similar. However, harvest mass of HAR pintails averaged 1 33 g (SE=25 g) less than UMK pintails; loss tended to be greatest for heavier HY females in 1 993. Daily survival rates during 1 993-1 994 of HAR vs. SSU pintails were similar for both HY (0.9979 vs. 0.9974) and AHY (0.9988 vs. 0.9986) female pintails. Retention ranged from 30-1 58 days (x=81 d, SE=5 d) for the 37 SSU that I confirmed as being shed; all other SSU failed 1-month studies due to poor retention past a month.

Techniques and instrumentation effort for whale migration tracking

NASA Technical Reports Server (NTRS)

Goodman, R. M.; Norris, K. S.; Hobbs, L.; Gibson, R. J.; Dougherty, E.; Palladino, J.

1975-01-01

The following aspects of a research program concerned with tracking gray whales were documented: (1) design, fabrication and testing of a girdle-type harness and associated gear (release mechanism, tracking transmitter, xenon flasher), (2) design, fabrication and testing of instrumentation packs (subminiature recorder, sensor, electronics), (3) field preparations for the January-February 1974 expedition off Mexico, (4) travel arrangements, (5) preliminary field report (capture and handling of juvenile whales, instrumentation and housing tests, harness abrasion and chafing, respiration measurements, sea tracking, distribution, number, and behavior of whales at Lopez Mateos), (6) review, data reduction, and analysis of results.

On the usage of classical nucleation theory in quantification of the impact of bacterial INP on weather and climate

NASA Astrophysics Data System (ADS)

Sahyoun, Maher; Wex, Heike; Gosewinkel, Ulrich; Šantl-Temkiv, Tina; Nielsen, Niels W.; Finster, Kai; Sørensen, Jens H.; Stratmann, Frank; Korsholm, Ulrik S.

2016-08-01

Bacterial ice-nucleating particles (INP) are present in the atmosphere and efficient in heterogeneous ice-nucleation at temperatures up to -2 °C in mixed-phase clouds. However, due to their low emission rates, their climatic impact was considered insignificant in previous modeling studies. In view of uncertainties about the actual atmospheric emission rates and concentrations of bacterial INP, it is important to re-investigate the threshold fraction of cloud droplets containing bacterial INP for a pronounced effect on ice-nucleation, by using a suitable parameterization that describes the ice-nucleation process by bacterial INP properly. Therefore, we compared two heterogeneous ice-nucleation rate parameterizations, denoted CH08 and HOO10 herein, both of which are based on classical-nucleation-theory and measurements, and use similar equations, but different parameters, to an empirical parameterization, denoted HAR13 herein, which considers implicitly the number of bacterial INP. All parameterizations were used to calculate the ice-nucleation probability offline. HAR13 and HOO10 were implemented and tested in a one-dimensional version of a weather-forecast-model in two meteorological cases. Ice-nucleation-probabilities based on HAR13 and CH08 were similar, in spite of their different derivation, and were higher than those based on HOO10. This study shows the importance of the method of parameterization and of the input variable, number of bacterial INP, for accurately assessing their role in meteorological and climatic processes.

Engineering and experimental analyses of the tensile loads applied during strength testing of direct bonded orthodontic brackets.

PubMed

Katona, T R; Chen, J

1994-08-01

The stress levels within the cement layer (hence, the apparent strength) of a direct bonded orthodontic bracket depends, to a large extent, on the alignment of the tensile loads that are applied to the specimen. The purpose of this analysis was to determine how the construction of a ligature wire harness affects the alignment of the applied loads. Tensile tests conducted on a modified bracket/cement system showed large variations in the force-elongation curve profiles. An engineering model was developed to explain these deviations. The results indicate that it is virtually impossible to evenly apply tensile loads to the bracket. It was also proposed that long harnesses constructed with thin ligature wire, prestressing the harness, and lubrication may reduce some of the effects of unavoidable load-bracket misalignment.

[Vascular thrombosis and pulmonary thrombo-embolism due to harness suspension].

PubMed

Pisati, G; Cerri, S; Achille, G; Rossi, G; Lorenzi, G

2007-01-01

In many sports (such as rock-climbing and caving) and working activities (e.g., construction and maintenance of buildings, pruning of lung-trunked trees, abseiling in wells) people run the risk of falling from a height. To prevent the effects of any potential fall, personalprotection devices consisting of at least a body holding device (i.e. a harness of some type), a lanyard and a reliable anchor are used. Reporting on the occurrence of vascular thrombosis in subjects undergoing prolonged hanging in a harness, either for work or recreation. We investigated patients treated for vascular thrombosis in our hospital in the last 5 years to identify subjects with frequent use of a harness. We identified a 36-year-old rock-climber who developed pulmonary thrombo-embolism and infarction 5 days after he had been wearing a harness for 12 hours consecutively, and a 32 year-old worker who often used a harness to fix wire-nettings to prevent rocks falling from steep places and suffered thrombosis of the left superficial femoral artery. A feature of both cases was the considerable length of time spent hanging in the harness and the absence of alternative risk factors for thrombosis. Prolonged hanging in a harness can be dangerous in itself because it can produce vascular thrombosis. Reduction of intravascular blood flow (stasis) and compression of the femoral veins by harness groin straps were the likely pathogenetic mechanisms of the described diseases. The importance is stressed of prevention, which must be based on planned regular breaks in the hanging position, checking on the fit and comfort level of the harness before it is first used, as well as medical surveillance of the subjects who spend prolonged periods in a harness for work or recreation.

Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing.

PubMed

Sorbello, Alfred; Ripple, Anna; Tonning, Joseph; Munoz, Monica; Hasan, Rashedul; Ly, Thomas; Francis, Henry; Bodenreider, Olivier

2017-03-22

We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use. All usability test participants cited the tool's ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool's automated literature search relative to a manual 'all fields' PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction.

Text to Speech (TTS) Capabilities for the Common Driver Trainer (CDT)

DTIC Science & Technology

2010-10-01

harnessing in’leigle jalClpeno jocelyn linu ~ los angeles lottery margarine mathematlze mathematized mathematized meme memes memol...including Julie, Kate, and Paul . Based upon the names of the voices, it may be that the VoiceText capability is the technology being used currently on...DFTTSExportToFileEx(O, " Paul ", 1, 1033, "Testing the Digital Future Text-to-Speech SDK.", -1, -1, -1, -1, -1, DFTTS_ TEXT_ TYPE_ XML, "test.wav", 0, "", -1

Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon.

PubMed

Cheng, Feiyue; Gong, Luyao; Zhao, Dahe; Yang, Haibo; Zhou, Jian; Li, Ming; Xiang, Hua

2017-11-20

Research on CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated protein) systems has led to the revolutionary CRISPR/Cas9 genome editing technique. However, for most archaea and half of bacteria, exploitation of their native CRISPR-Cas machineries may be more straightforward and convenient. In this study, we harnessed the native type I-B CRISPR-Cas system for precise genome editing in the polyploid haloarchaeon Haloarcula hispanica. After testing different designs, the editing tool was optimized to be a single plasmid that carries both the self-targeting mini-CRISPR and a 600-800 bp donor. Significantly, chromosomal modifications, such as gene deletion, gene tagging or single nucleotide substitution, were precisely introduced into the vast majority of the transformants. Moreover, we showed that simultaneous editing of two genomic loci could also be readily achieved by one step. In summary, our data demonstrate that the haloarchaeal CRISPR-Cas system can be harnessed for genome editing in this polyploid archaeon, and highlight the convenience and efficiency of the native CRISPR-based genome editing strategy. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Sharp-Tip Silver Nanowires Mounted on Cantilevers for High-Aspect-Ratio High-Resolution Imaging.

PubMed

Ma, Xuezhi; Zhu, Yangzhi; Kim, Sanggon; Liu, Qiushi; Byrley, Peter; Wei, Yang; Zhang, Jin; Jiang, Kaili; Fan, Shoushan; Yan, Ruoxue; Liu, Ming

2016-11-09

Despite many efforts to fabricate high-aspect-ratio atomic force microscopy (HAR-AFM) probes for high-fidelity, high-resolution topographical imaging of three-dimensional (3D) nanostructured surfaces, current HAR probes still suffer from unsatisfactory performance, low wear-resistivity, and extravagant prices. The primary objective of this work is to demonstrate a novel design of a high-resolution (HR) HAR AFM probe, which is fabricated through a reliable, cost-efficient benchtop process to precisely implant a single ultrasharp metallic nanowire on a standard AFM cantilever probe. The force-displacement curve indicated that the HAR-HR probe is robust against buckling and bending up to 150 nN. The probes were tested on polymer trenches, showing a much better image fidelity when compared with standard silicon tips. The lateral resolution, when scanning a rough metal thin film and single-walled carbon nanotubes (SW-CNTs), was found to be better than 8 nm. Finally, stable imaging quality in tapping mode was demonstrated for at least 15 continuous scans indicating high resistance to wear. These results demonstrate a reliable benchtop fabrication technique toward metallic HAR-HR AFM probes with performance parallel or exceeding that of commercial HAR probes, yet at a fraction of their cost.

A test harness for accelerating physics parameterization advancements into operations

NASA Astrophysics Data System (ADS)

Firl, G. J.; Bernardet, L.; Harrold, M.; Henderson, J.; Wolff, J.; Zhang, M.

2017-12-01

The process of transitioning advances in parameterization of sub-grid scale processes from initial idea to implementation is often much quicker than the transition from implementation to use in an operational setting. After all, considerable work must be undertaken by operational centers to fully test, evaluate, and implement new physics. The process is complicated by the scarcity of like-to-like comparisons, availability of HPC resources, and the ``tuning problem" whereby advances in physics schemes are difficult to properly evaluate without first undertaking the expensive and time-consuming process of tuning to other schemes within a suite. To address this process shortcoming, the Global Model TestBed (GMTB), supported by the NWS NGGPS project and undertaken by the Developmental Testbed Center, has developed a physics test harness. It implements the concept of hierarchical testing, where the same code can be tested in model configurations of varying complexity from single column models (SCM) to fully coupled, cycled global simulations. Developers and users may choose at which level of complexity to engage. Several components of the physics test harness have been implemented, including a SCM and an end-to-end workflow that expands upon the one used at NOAA/EMC to run the GFS operationally, although the testbed components will necessarily morph to coincide with changes to the operational configuration (FV3-GFS). A standard, relatively user-friendly interface known as the Interoperable Physics Driver (IPD) is available for physics developers to connect their codes. This prerequisite exercise allows access to the testbed tools and removes a technical hurdle for potential inclusion into the Common Community Physics Package (CCPP). The testbed offers users the opportunity to conduct like-to-like comparisons between the operational physics suite and new development as well as among multiple developments. GMTB staff have demonstrated use of the testbed through a comparison between the 2017 operational GFS suite and one containing the Grell-Freitas convective parameterization. An overview of the physics test harness and its early use will be presented.

Advanced air revitalization for optimized crew and plant environments

NASA Technical Reports Server (NTRS)

Lee, M. G.; Grigger, David J.; Brown, Mariann F.

1991-01-01

The Hybrid Air Revitalization System (HARS) closed ecosystem concept presented encompasses electrochemical CO2 and O2 separators, in conjunction with a mechanical condenser/separator for maintaining CO2, O2, and humidity levels in crew and plant habitats at optimal conditions. HARS requires no expendables, and allows flexible process control on the bases of electrochemical cell current, temperature, and airflow rate variations. HARS capacity can be easily increased through the incorporation of additional chemical cells. Detailed system flowcharts are provided.

Harnessing Scientific Literature Reports for Pharmacovigilance

PubMed Central

Ripple, Anna; Tonning, Joseph; Munoz, Monica; Hasan, Rashedul; Ly, Thomas; Francis, Henry; Bodenreider, Olivier

2017-01-01

Summary Objectives We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers’ capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. Methods A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use. Results All usability test participants cited the tool’s ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool’s automated literature search relative to a manual ‘all fields’ PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Conclusions Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction. PMID:28326432

Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2.

PubMed

Fugel, Malte; Jayatilaka, Dylan; Hupf, Emanuel; Overgaard, Jacob; Hathwar, Venkatesha R; Macchi, Piero; Turner, Michael J; Howard, Judith A K; Dolomanov, Oleg V; Puschmann, Horst; Iversen, Bo B; Bürgi, Hans-Beat; Grabowsky, Simon

2018-01-01

Hirshfeld atom refinement (HAR) is a novel X-ray structure refinement technique that employs aspherical atomic scattering factors obtained from stockholder partitioning of a theoretically determined tailor-made static electron density. HAR overcomes many of the known limitations of independent atom modelling (IAM), such as too short element-hydrogen distances, r ( X -H), or too large atomic displacement parameters (ADPs). This study probes the accuracy and precision of anisotropic hydrogen and non-hydrogen ADPs and of r ( X -H) values obtained from HAR. These quantities are compared and found to agree with those obtained from (i) accurate neutron diffraction data measured at the same temperatures as the X-ray data and (ii) multipole modelling (MM), an established alternative method for interpreting X-ray diffraction data with the help of aspherical atomic scattering factors. Results are presented for three chemically different systems: the aromatic hydro-carbon rubrene (orthorhombic 5,6,11,12-tetra-phenyl-tetracene), a co-crystal of zwitterionic betaine, imidazolium cations and picrate anions (BIPa), and the salt potassium hydrogen oxalate (KHOx). The non-hydrogen HAR-ADPs are as accurate and precise as the MM-ADPs. Both show excellent agreement with the neutron-based values and are superior to IAM-ADPs. The anisotropic hydrogen HAR-ADPs show a somewhat larger deviation from neutron-based values than the hydrogen SHADE-ADPs used in MM. Element-hydrogen bond lengths from HAR are in excellent agreement with those obtained from neutron diffraction experiments, although they are somewhat less precise. The residual density contour maps after HAR show fewer features than those after MM. Calculating the static electron density with the def2-TZVP basis set instead of the simpler def2-SVP one does not improve the refinement results significantly. All HARs were performed within the recently introduced HARt option implemented in the Olex2 program. They are easily launched inside its graphical user interface following a conventional IAM.

Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2

PubMed Central

Fugel, Malte; Hathwar, Venkatesha R.; Turner, Michael J.; Howard, Judith A. K.

2018-01-01

Hirshfeld atom refinement (HAR) is a novel X-ray structure refinement technique that employs aspherical atomic scattering factors obtained from stockholder partitioning of a theoretically determined tailor-made static electron density. HAR overcomes many of the known limitations of independent atom modelling (IAM), such as too short element–hydrogen distances, r(X—H), or too large atomic displacement parameters (ADPs). This study probes the accuracy and precision of anisotropic hydrogen and non-hydrogen ADPs and of r(X—H) values obtained from HAR. These quantities are compared and found to agree with those obtained from (i) accurate neutron diffraction data measured at the same temperatures as the X-ray data and (ii) multipole modelling (MM), an established alternative method for interpreting X-ray diffraction data with the help of aspherical atomic scattering factors. Results are presented for three chemically different systems: the aromatic hydro­carbon rubrene (orthorhombic 5,6,11,12-tetra­phenyl­tetracene), a co-crystal of zwitterionic betaine, imidazolium cations and picrate anions (BIPa), and the salt potassium hydrogen oxalate (KHOx). The non-hydrogen HAR-ADPs are as accurate and precise as the MM-ADPs. Both show excellent agreement with the neutron-based values and are superior to IAM-ADPs. The anisotropic hydrogen HAR-ADPs show a somewhat larger deviation from neutron-based values than the hydrogen SHADE-ADPs used in MM. Element–hydrogen bond lengths from HAR are in excellent agreement with those obtained from neutron diffraction experiments, although they are somewhat less precise. The residual density contour maps after HAR show fewer features than those after MM. Calculating the static electron density with the def2-TZVP basis set instead of the simpler def2-SVP one does not improve the refinement results significantly. All HARs were performed within the recently introduced HARt option implemented in the Olex2 program. They are easily launched inside its graphical user interface following a conventional IAM. PMID:29354269

Acoustic vibration test detects intermittent electrical discontinuities

NASA Technical Reports Server (NTRS)

Grieve, S. M.; Roberts, D. E.

1970-01-01

Nondestructive test method detects faulty electrical connections in inaccessible or hidden portions of electronic harness assemblies and connectors. Method employs readily available commercial equipment.

Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry.

PubMed

Wolf, Dominik; Bocchetta, Martina; Preboske, Gregory M; Boccardi, Marina; Grothe, Michel J

2017-08-01

A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software. Individual tracings showed very high agreement among the four expert tracers (pairwise Jaccard indices 0.82-0.87). Automatically calculated hippocampal volumes were highly correlated (r L/R  = 0.89/0.91) with gold standard volumes in the HarP benchmark data set (N = 135 MRIs), with a mean volume difference of 9% (standard deviation 7%). The consensual HarP hippocampus labels in the MNI152 template can serve as a reference standard for automated image analyses involving MNI standard space normalization. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

KENNEDY SPACE CENTER, FLA. - Jeff Thon, an SRB mechanic with United Space Alliance, is fitted with a harness to test a vertical solid rocket booster propellant grain inspection technique. Thon will be lowered inside a mockup of two segments of the SRBs. The inspection of segments is required as part of safety analysis.

NASA Image and Video Library

2003-09-11

KENNEDY SPACE CENTER, FLA. - Jeff Thon, an SRB mechanic with United Space Alliance, is fitted with a harness to test a vertical solid rocket booster propellant grain inspection technique. Thon will be lowered inside a mockup of two segments of the SRBs. The inspection of segments is required as part of safety analysis.

Rapid Prediction of Hematologic Acute Radiation Syndrome in Radiation Injury Patients Using Peripheral Blood Cell Counts.

PubMed

Port, M; Pieper, B; Knie, T; Dörr, H; Ganser, A; Graessle, D; Meineke, V; Abend, M

2017-08-01

Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic interventions. We examined the utility of blood cell counts (BCCs) in the first three days postirradiation to predict clinical outcome, specifically for hematologic acute radiation syndrome (HARS). We analyzed BCC test samples from radiation accident victims (n = 135) along with their clinical outcome HARS severity scores (H1-4) using the System for Evaluation and Archiving of Radiation Accidents based on Case Histories (SEARCH) database. Data from nonirradiated individuals (H0, n = 132) were collected from an outpatient facility. We created binary categories for severity scores, i.e., 1 (H0 vs. H1-4), 2 (H0-1 vs. H2-4) and 3 (H0-2 vs. H3-4), to assess the discrimination ability of BCCs using unconditional logistic regression analysis. The test sample contained 454 BCCs from 267 individuals. We validated the discrimination ability on a second independent group comprised of 275 BCCs from 252 individuals originating from SEARCH (HARS 1-4), an outpatient facility (H0) and hospitals (e.g., leukemia patients, H4). Individuals with a score of H0 were easily separated from exposed individuals based on developing lymphopenia and granulocytosis. The separation of H0 and H1-4 became more prominent with increasing hematologic severity scores and time. On day 1, lymphocyte counts were most predictive for discriminating binary categories, followed by granulocytes and thrombocytes. For days 2 and 3, an almost complete separation was achieved when BCCs from different days were combined, supporting the measurement of sequential BCC. We found an almost complete discrimination of H0 vs. irradiated individuals during model validation (negative predictive value, NPV > 94%) for all three days, while the correct prediction of exposed individuals increased from day 1 (positive predictive value, PPV 78-89%) to day 3 (PPV > 90%). The models were unable to provide predictions for 10.9% of the test samples, because the PPVs or NPVs did not reach a 95% likelihood defined as the lower limit for a prediction. We developed a prediction model spreadsheet to provide early and prompt diagnostic predictions and therapeutic recommendations including identification of the worried well, requirement of hospitalization or development of severe hematopoietic syndrome. These results improve the provisional classification of HARS. For the final diagnosis, further procedures (sequential diagnosis, retrospective dosimetry, clinical follow-up, etc.) must be taken into account. Clinical outcome of radiation injury patients can be rapidly predicted within the first three days postirradiation using peripheral BCC.

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity.

PubMed

Frisoni, Giovanni B; Jack, Clifford R; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G; deToledo-Morrell, Leyla; Geerlings, Mirjam I; Kaye, Jeffrey; Killiany, Ronald J; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina

2015-02-01

An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

PubMed Central

Frisoni, Giovanni B.; Jack, Clifford R.; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S.; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J.; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G.; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G.; deToledo-Morrell, Leyla; Geerlings, Mirjam I.; Kaye, Jeffrey; Killiany, Ronald J.; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C.; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C.; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; Pasqualetti, Patrizio; Duchesne, Simon; Duvernoy, Henri; Boccardi, Marina

2015-01-01

Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). Conclusions The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. PMID:25267715

High Speed Link Radiated Emission Reduction

NASA Astrophysics Data System (ADS)

Bisognin, P.; Pelissou, P.; Cissou, R.; Giniaux, M.; Vargas, O.

2016-05-01

To control the radiated emission of high-speed link and associated unit, the current approach is to implement overall harness shielding on cables bundles. This method is very efficient in the HF/ VHF (high frequency/ very high frequency) and UHF (ultra-high frequency) ranges when the overall harness shielding is properly bonded on EMC back-shell. Unfortunately, with the increasing frequency, the associated half wavelength matches with the size of Sub-D connector that is the case for the L band. Therefore, the unit connectors become the main source of interference emission. For the L-band and S-band, the current technology of EMC back-shell leaves thin aperture matched with the L band half wavelength and therefore, the shielding effectiveness is drastically reduced. In addition, overall harness shielding means significant increases of the harness mass.Airbus D&S Toulouse and Elancourt investigated a new solution to avoid the need of overall harness shielding. The objective is to procure EM (Electro-Magnetic) clean unit connected to cables bundles free of any overall harness shielding. The proposed solution is to implement EMC common mode filtering on signal interfaces directly on unit PCB as close as possible the unit connector.Airbus D&S Elancourt designed and manufactured eight mock-ups of LVDS (Low Voltage Differential Signaling) interface PCBs' with different solutions of filtering. After verification of the signal integrity, three mock-ups were retained (RC filter and two common mode choke coil) in addition to the reference one (without EMC filter).Airbus D&S Toulouse manufactured associated LVDS cable bundles and integrated the RX (Receiver) and TX (Transmitter) LVDS boards in shielded boxes.Then Airbus D&S performed radiated emission measurement of the LVDS links subassemblies (e.g. RX and TX boxes linked by LVDS cables) according to the standard test method. This paper presents the different tested solutions and main conclusions on the feasibility of such approach.

A REFORMULATED, RECONSTITUTED WATER FOR TESTING THE FRESHWATER AMPHIPOD, HYALELLA AZTECA

EPA Science Inventory

Toxicity testing with the freshwater amphipod, Hyalella azteca, has routinely been conducted using nonstandard waters. Four waters tested for acceptability for aqueous reference toxicant testing with H. azteca. These included three formulated (standardized) waters: moderately har...

Design of a noninvasive face mask for ocular occlusion in rats and assessment in a visual discrimination paradigm.

PubMed

Hager, Audrey M; Dringenberg, Hans C

2012-12-01

The rat visual system is structured such that the large (>90 %) majority of retinal ganglion axons reach the contralateral lateral geniculate nucleus (LGN) and visual cortex (V1). This anatomical design allows for the relatively selective activation of one cerebral hemisphere under monocular viewing conditions. Here, we describe the design of a harness and face mask allowing simple and noninvasive monocular occlusion in rats. The harness is constructed from synthetic fiber (shoelace-type material) and fits around the girth region and neck, allowing for easy adjustments to fit rats of various weights. The face mask consists of soft rubber material that is attached to the harness by Velcro strips. Eyeholes in the mask can be covered by additional Velcro patches to occlude either one or both eyes. Rats readily adapt to wearing the device, allowing behavioral testing under different types of viewing conditions. We show that rats successfully acquire a water-maze-based visual discrimination task under monocular viewing conditions. Following task acquisition, interocular transfer was assessed. Performance with the previously occluded, "untrained" eye was impaired, suggesting that training effects were partially confined to one cerebral hemisphere. The method described herein provides a simple and noninvasive means to restrict visual input for studies of visual processing and learning in various rodent species.

Wireless Self-Acquistion of 12-Lead ECG via Android Smart Phone

NASA Technical Reports Server (NTRS)

Schlegel, Todd T.

2012-01-01

Researchers at NASA s Johnson Space Center and at Orbital Research, Inc. (a NASA SBIR grant recipient) have recently developed a dry-electrode harness that allows for self-acquisition of resting 12-lead ECGs by minimally trained laypersons. When used in conjunction with commercial wireless (e.g., Bluetooth(TM) or 802.11-enabled) 12-lead ECG devices and custom smart phone-based software, the collected 12-lead ECG data can also immediately be forwarded from any geographic location within cellular range to the user s physician(s) of choice. The system can also be used to immediately forward to central receiving stations 12-lead ECG data collected during space flight or during activities in any remote terrestrial location supported by an internet or cellular phone infrastructure. The main novel aspects of the system are first, the dry-electrode 12-lead ECG harness itself, and second, an accompanying Android(TM) smart phone-based wireless 12-lead ECG capability. The ECG harness nominally employs dry electrodes manufactured by Orbital Research, Inc, recently cleared through the Food and Drug Administration (FDA). However, other dry electrodes that are not yet FDA cleared, for example those recently developed by Nanosonic, Inc as part of another NASA SBIR grant, can also be used. The various advantageous features of the harness include: 1) laypersons can be quickly instructed on its correct use, remotely if necessary; 2) all tangled "leadwire spaghetti" is eliminated, as is the common clinical problem of "leadwire reversal"; 3) all adhesives and disposables are also eliminated, the harness being fully reusable; if multiple individuals intend to use use the same harness, then standard antimicrobial wipes can be employed to sterilize the dry electrodes (and harness surface if needed) between users; 5) padded cushions at the lateral sides of the torso function to press the left arm (LA) and right arm (RA) dry electrodes mounted on the cushions against sideward or downward-rested arms of the subject; 6) sufficient distal placement of the arm electrodes achieves good electrode abutment to the arms without the need for adhesives, straps, bands, bracelets, or gloves; 7) padding over the sternum avoids "tenting" in the V1 through V3 (and, when present, the V3R) electrode positions; 8) easy-to-don, one-piece design with an adjustable, front-side single point of connection and an adjustable shoulder strap; and 9) Lund or "modified Lund" placement of the dry electrodes, the results of which more effectively reproduce results from "standard" 12-lead ECG placements than do results from Mason-Likar placements. The main limitation of the harness is that "one size does not fit all", meaning that an appropriately sized harness (small, medium, large, etc) must be chosen on the basis of an individual's size. To facilitate the use of the harness with inexpensive, commodity-grade cell phones and tablet devices, 12-lead ECG software is also being developed to accompany the harness for wireless use with Android. For this part of the project, NASA has teamed with TopCoder, Inc and the Harvard-affiliated NASA Tournament Lab in sponsoring java-based software programming contests through TopCoder. While ECG signals from the harness can already be wirelessly received and thoroughly processed (locally or remotely) by commercial-grade conventional (as well as advanced) 12-lead ECG software running on Microsoft Windows(TM), the Android-based software, once completed, will "cast a wider net" by allowing for a greater percentage of cell phone owners to participate in inexpensive, store-and-forward recordings of 12-lead ECGs worldwide, including for example Android cell phone users in many remote, third-world locations. At the time of writing, the Android 12-lead ECG software platform consists of a basic but expanding graphical user interface and accompanying software that: 1) wirelessly receives the 12-lead ECG data stream from a Bluetooth-based, FDA-cleared 12-leaCG device attached to the harness; 2) locally stores the same data in binary format to the SD card on the Android cell phone; and 3) makes the data stream in available in real time, for now to TopCoder's java programming contestants.

[Binding interaction of harpagoside and bovine serum albumin: spectroscopic methodologies and molecular docking].

PubMed

Cao, Tuan-Wu; Huang, Wen-Bing; Shi, Jian-Wei; He, Wei

2018-03-01

Scrophularia ningpoensis has exhibited a variety of biological activities and been used as a pharmaceutical product for the treatment of inflammatory ailment, rheumatoid arthritis, osteoarthritis and so on. Harpagoside (HAR) is considerer as a main bioactive compound in this plant. Serum albumin has important physiological roles in transportation, distribution and metabolism of many endogenous and exogenous substances in body. It is of great significance to study the interaction mechanism between HAR and bovine serum albumin (BSA). The mechanism of interaction between HAR and BSA was investigated using 2D and 3D fluorescence, synchronous florescence, ultraviolet spectroscopy and molecular docking. According to the analysis of fluorescence spectra, HAR could strongly quench the fluorescence of BSA, and the static quenching process indicated that the decrease in the quenching constant was observed with the increase in temperature. The magnitude of binding constants (KA) was more than 1×10⁵ L·mol⁻¹, and the number of binding sites(n) was approximate to 1. The thermodynamic parameters were calculated through analysis of fluorescence data with Stern-Volmer and Van't Hoff equation. The calculated enthalpy change (ΔH) and entropy change (ΔS) implied that the main interaction forces of HAR with BSA were the bonding interaction between van der Waals forces and hydrogen. The negative values of energy (ΔG) demonstrated that the binding of HAR with BSA was a spontaneous and exothermic process. The binding distance(r) between HAR and BSA was calculated to be about 2.80 nm based on the theory of Frster's non-radiation energy transfer, which indicated that energy is likely to be transfer from BSA to HAR. Both synchronous and 3D florescence spectroscopy clearly revealed that the microenvironment and conformation of BSA changed during the binding interaction between HAR and BSA. The molecular docking analysis revealed HAR is more inclined to BSA and human serum albumin (HSA) in subdomain ⅡA (Sudlow's site I). This study will provide valuable information for understanding the action mechanism of HAR. Copyright© by the Chinese Pharmaceutical Association.

Evaluation of a smartphone human activity recognition application with able-bodied and stroke participants.

PubMed

Capela, N A; Lemaire, E D; Baddour, N; Rudolf, M; Goljar, N; Burger, H

2016-01-20

Mobile health monitoring using wearable sensors is a growing area of interest. As the world's population ages and locomotor capabilities decrease, the ability to report on a person's mobility activities outside a hospital setting becomes a valuable tool for clinical decision-making and evaluating healthcare interventions. Smartphones are omnipresent in society and offer convenient and suitable sensors for mobility monitoring applications. To enhance our understanding of human activity recognition (HAR) system performance for able-bodied and populations with gait deviations, this research evaluated a custom smartphone-based HAR classifier on fifteen able-bodied participants and fifteen participants who suffered a stroke. Participants performed a consecutive series of mobility tasks and daily living activities while wearing a BlackBerry Z10 smartphone on their waist to collect accelerometer and gyroscope data. Five features were derived from the sensor data and used to classify participant activities (decision tree). Sensitivity, specificity and F-scores were calculated to evaluate HAR classifier performance. The classifier performed well for both populations when differentiating mobile from immobile states (F-score > 94 %). As activity recognition complexity increased, HAR system sensitivity and specificity decreased for the stroke population, particularly when using information derived from participant posture to make classification decisions. Human activity recognition using a smartphone based system can be accomplished for both able-bodied and stroke populations; however, an increase in activity classification complexity leads to a decrease in HAR performance with a stroke population. The study results can be used to guide smartphone HAR system development for populations with differing movement characteristics.

The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications

PubMed Central

Cadwallader, Amy B.; Lim, Carol S.; Rollins, Douglas E.; Botrè, Francesco

2015-01-01

Steroid abuse is a growing problem among amateur and professional athletes. Because of an inundation of newly and illegally synthesized steroids with minor structural modifications and other designer steroid receptor modulators, there is a need to develop new methods of detection which do not require prior knowledge of the abused steroid structure. The number of designer steroids currently being abused is unknown because detection methods in general are only identifying substances with a known structure. The detection of doping is moving away from merely checking for exposure to prohibited substance toward detecting an effect of prohibited substances, as biological assays can do. Cell-based biological assays are the next generation of assays which should be utilized by antidoping laboratories; they can detect androgenic anabolic steroid and other human androgen receptor (hAR) ligand presence without knowledge of their structure and assess the relative biological activity of these compounds. This review summarizes the hAR and its action and discusses its relevance to sports doping and its use in biological assays. PMID:22080898

Jet-Surface Interaction: High Aspect Ratio Nozzle Test, Nozzle Design and Preliminary Data

NASA Technical Reports Server (NTRS)

Brown, Clifford; Dippold, Vance

2015-01-01

The Jet-Surface Interaction High Aspect Ratio (JSI-HAR) nozzle test is part of an ongoing effort to measure and predict the noise created when an aircraft engine exhausts close to an airframe surface. The JSI-HAR test is focused on parameters derived from the Turbo-electric Distributed Propulsion (TeDP) concept aircraft which include a high-aspect ratio mailslot exhaust nozzle, internal septa, and an aft deck. The size and mass flow rate limits of the test rig also limited the test nozzle to a 16:1 aspect ratio, half the approximately 32:1 on the TeDP concept. Also, unlike the aircraft, the test nozzle must transition from a single round duct on the High Flow Jet Exit Rig, located in the AeroAcoustic Propulsion Laboratory at the NASA Glenn Research Center, to the rectangular shape at the nozzle exit. A parametric nozzle design method was developed to design three low noise round-to-rectangular transitions, with 8:1, 12:1, and 16: aspect ratios, that minimizes flow separations and shocks while providing a flat flow profile at the nozzle exit. These designs validated using the WIND-US CFD code. A preliminary analysis of the test data shows that the actual flow profile is close to that predicted and that the noise results appear consistent with data from previous, smaller scale, tests. The JSI-HAR test is ongoing through October 2015. The results shown in the presentation are intended to provide an overview of the test and a first look at the preliminary results.

Effects of satellite transmitters on captive and wild mallards

USGS Publications Warehouse

Kesler, Dylan C.; Raedeke, Andrew H.; Foggia, Jennifer R.; Beatty, William S.; Webb, Elisabeth B.; Humburg, Dale D.; Naylor, Luke W.

2014-01-01

Satellite telemetry has become a leading method for studying large-scale movements and survival in birds, yet few have addressed potential effects of the larger and heavier tracking equipment on study subjects. We simultaneously evaluated effects of satellite telemetry equipment on captive and wild mallards (Anas platyrhynchos) to assess impacts on behavior, body mass, and movement. We randomly assigned 55 captive ducks to one of 3 treatment groups, including a standard body harness group, a modified harness group, and a control group. Ducks in the control group were not fitted with equipment, whereas individuals in the other 2 groups were fitted with dummy transmitters attached with a Teflon ribbon harness or with a similar harness constructed of nylon cord. At the conclusion of the 14-week captive study, mean body mass of birds in the control group was 40–105 g (95% CI) greater than birds with standard harnesses, and 28–99 g (95% CI) greater than birds with modified harnesses. Further, results of focal behavior observations indicated ducks with transmitters were less likely to be in water than control birds. We also tested whether movements of wild birds marked with a similar Teflon harness satellite transmitter aligned with population movements reported by on-the-ground observers who indexed local abundances of mid-continent mallards throughout the non-breeding period. Results indicated birds marked with satellite transmitters moved concurrently with the larger unmarked population. Our results have broad implications for field research and suggest that investigators should consider potential for physiological and behavioral effects brought about by tracking equipment. Nonetheless, results from wild ducks indicate satellite telemetry has the potential to provide useful movement data.

Comparison of Piezo-material based Energy Transduction Systems for Artificial Nanoswimmer

NASA Astrophysics Data System (ADS)

Nain, S.; Rathore, J. S.; Sharma, N. N.

2018-04-01

The energy harnessing is a process of obtaining energy from the surrounding environment and converting into electrical energy. In the last two decades, there has been a plenteous study in energy harnessing. Now a day, energy harnessing using piezoelectric materials has drawn attention of researchers due to low cost, flexibility and light weight. The benefits of piezoelectric material can be utilized by designing a self-powered device for artificial nanoswimmer. Some of the ceramics which displays the piezoelectric effect are lead-zirconate-titanate (PZT), lead-titanate (PbTiO2), lead-zirconate (PbZrO3) and Barium Titanate (BaTiO3). PZT is most extensively used piezoelectric material in the field of energy harnessing but it is brittle in nature. Lead based piezoelectric materials are toxic in nature and may not suitable for in-vivo biomedical applications. To eradicate this problem, researchers are interested in synthesizing lead free piezoelectric material such as Aluminium Nitride (AIN), Barium Titanate (BaTiO3) and Polyvinylidenefluoride (PVDF). The biocompatibility of PVDF makes it appropriate to be used for energy harnessing in human body for applications like on board powering of nanoswimmer for various disease detection and drug delivery. In this paper, a cantilever beam is being simulated in COMSOL to study electric potential generated on the surface of beam made of different piezoelectric materials such as AIN, PVDF and PZT due to fluidic pressure, which will be utilized as energy for actuation of artificial nanoswimmer. Piezo-based cantilever beams have been compared and maximum electric potential is being observed in PVDF based beam. PVDF seems most promising piezoelectric material for in-vivo biomedical application and it is readily available.

A Completely New Type of Actuator -or- This Ain't Your Grandfather's Internal Combustion Engine

NASA Technical Reports Server (NTRS)

Gore, Brian W.; Hawkins, Gary F.; Hess, Peter A.; Moore, Teresa A.; Fournier, Eric W.

2010-01-01

A completely new type of actuator - one that is proposed for use in a variety of environments from sea to land to air to space - has been designed, patented, built, and tested. The actuator is loosely based on the principle of the internal combustion engine, except that it is a completely closed system, only requiring electrical input, and the working fuel is water. This paper outlines the theory behind the electrolysis- and ignition-based cycle upon which the actuator operates and describes the performance capability test apparatus and results for the actuator. A mechanism application that harnessed the unit s power to twist a scaled rotor blade is also highlighted.

NASA requirements and applications environments for electrical power wiring

NASA Technical Reports Server (NTRS)

Stavnes, Mark W.; Hammoud, Ahmad N.

1992-01-01

Serious problems can occur from insulation failures in the wiring harnesses of aerospace vehicles. In most recorded incidents, the failures have been identified to be the result of arc tracking, the propagation of an arc along wiring bundles through degradation of insulation. Propagation of the arc can lead to the loss of the entire wiring harness and the functions which it supports. While an extensive database of testing for arc track resistant wire insulations has been developed for aircraft applications, the counterpart requirements for spacecraft are very limited. The electrical, thermal, mechanical, chemical, and operational requirements for specification and testing of candidate wiring systems for spacecraft applications is presented.

Research progress and harnessing method of soil and water loss in Pisha Sandstone region

NASA Astrophysics Data System (ADS)

Xiao, P. Q.; Yang, C. X.; Jing, C. R.

2018-05-01

Pisha Sandstone region is the most vulnerable and the most dramatic area of soil erosion, severe soil erosion on the ecological bases of China’s energy security constitutes a serious challenge. Research progress of soil erosion in pisha Sandstone region was reviewed based on the need of soil and water ecological construction in Pisha Sandstone region and harnessing the yellow river including soil erosion mechanism, soil erosion dynamic monitoring and soil erosion simulation assessments. Meanwhile, the latest progress of soil and water conservation measures was analyzed, and the existing problems and future harnessing measures of soil and water loss were discussed. This study is to explore the comprehensive management method and provide scientific theory for constructing soil and water conservation project in Pisha Sandstone region.

Iosipescu shear properties of graphite fabric/epoxy composite laminates

NASA Technical Reports Server (NTRS)

Walrath, D. E.; Adams, D. F.

1985-01-01

The Iosipescu shear test method is used to measure the in-plane and interlaminar shear properties of four T300 graphite fabric/934 epoxy composite materials. Different weave geometries tested include an Oxford weave, a 5-harness satin weave, an 8-harness satin weave, and a plain weave with auxiliary warp yarns. Both orthogonal and quasi-isotropic layup laminates were tested. In-plane and interlaminar shear properties are obtained for laminates of all four fabric types. Overall, little difference in shear properties attributable to the fabric weave pattern is observed. The auxiliary warp material is significantly weaker and less stiff in interlaminar shear parallel to its fill direction. A conventional strain gage extensometer is modified to measure shear strains for use with the Iosipescu shear test. While preliminary results are encouraging, several design iterations failed to produce a reliable shear transducer prototype. Strain gages are still the most reliable shear strain transducers for use with this test method.

Ant-Based Cyber Defense (also known as

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glenn Fink, PNNL

2015-09-29

ABCD is a four-level hierarchy with human supervisors at the top, a top-level agent called a Sergeant controlling each enclave, Sentinel agents located at each monitored host, and mobile Sensor agents that swarm through the enclaves to detect cyber malice and misconfigurations. The code comprises four parts: (1) the core agent framework, (2) the user interface and visualization, (3) test-range software to create a network of virtual machines including a simulated Internet and user and host activity emulation scripts, and (4) a test harness to allow the safe running of adversarial code within the framework of monitored virtual machines.

Automatic recognition of falls in gait-slip training: Harness load cell based criteria.

PubMed

Yang, Feng; Pai, Yi-Chung

2011-08-11

Over-head-harness systems, equipped with load cell sensors, are essential to the participants' safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force, and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects' trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects' data revealed that the peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

AUTOMATIC RECOGNITION OF FALLS IN GAIT-SLIP: A HARNESS LOAD CELL BASED CRITERION

PubMed Central

Yang, Feng; Pai, Yi-Chung

2012-01-01

Over-head-harness systems, equipped with load cell sensors, are essential to the participants’ safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7-m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects’ trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects’ data revealed that peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1-s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. PMID:21696744

A Multi-Purpose Modular Electronics Integration Node for Exploration Extravehicular Activity

NASA Technical Reports Server (NTRS)

Hodgson, Edward; Papale, William; Wichowski, Robert; Rosenbush, David; Hawes, Kevin; Stankiewicz, Tom

2013-01-01

As NASA works to develop an effective integrated portable life support system design for exploration Extravehicular activity (EVA), alternatives to the current system s electrical power and control architecture are needed to support new requirements for flexibility, maintainability, reliability, and reduced mass and volume. Experience with the current Extravehicular Mobility Unit (EMU) has demonstrated that the current architecture, based in a central power supply, monitoring and control unit, with dedicated analog wiring harness connections to active components in the system has a significant impact on system packaging and seriously constrains design flexibility in adapting to component obsolescence and changing system needs over time. An alternative architecture based in the use of a digital data bus offers possible wiring harness and system power savings, but risks significant penalties in component complexity and cost. A hybrid architecture that relies on a set of electronic and power interface nodes serving functional models within the Portable Life Support System (PLSS) is proposed to minimize both packaging and component level penalties. A common interface node hardware design can further reduce penalties by reducing the nonrecurring development costs, making miniaturization more practical, maximizing opportunities for maturation and reliability growth, providing enhanced fault tolerance, and providing stable design interfaces for system components and a central control. Adaptation to varying specific module requirements can be achieved with modest changes in firmware code within the module. A preliminary design effort has developed a common set of hardware interface requirements and functional capabilities for such a node based on anticipated modules comprising an exploration PLSS, and a prototype node has been designed assembled, programmed, and tested. One instance of such a node has been adapted to support testing the swingbed carbon dioxide and humidity control element in NASA s advanced PLSS 2.0 test article. This paper will describe the common interface node design concept, results of the prototype development and test effort, and plans for use in NASA PLSS 2.0 integrated tests.

Testing and Benchmarking a 2014 GM Silverado 6L80 Six Speed Automatic Transmission

EPA Science Inventory

Describe the method and test results of EPA’s partial transmission benchmarking process which involves installing both the engine and transmission in an engine dynamometer test cell with the engine wire harness tethered to its vehicle parked outside the test cell.

Computer-Aided Engineering Of Cabling

NASA Technical Reports Server (NTRS)

Billitti, Joseph W.

1989-01-01

Program generates data sheets, drawings, and other information on electrical connections. DFACS program, centered around single data base, has built-in menus providing easy input of, and access to, data for all personnel involved in system, subsystem, and cabling. Enables parallel design of circuit-data sheets and drawings of harnesses. Also recombines raw information to generate automatically various project documents and drawings, including index of circuit-data sheets, list of electrical-interface circuits, lists of assemblies and equipment, cabling trees, and drawings of cabling electrical interfaces and harnesses. Purpose of program to provide engineering community with centralized data base for putting in, and gaining access to, functional definition of system as specified in terms of details of pin connections of end circuits of subsystems and instruments and data on harnessing. Primary objective to provide instantaneous single point of interchange of information, thus avoiding

Design Process Improvement for Electric CAR Harness

NASA Astrophysics Data System (ADS)

Sawatdee, Thiwarat; Chutima, Parames

2017-06-01

In an automobile parts design company, the customer satisfaction is one of the most important factors for product design. Therefore, the company employs all means to focus its product design process based on the various requirements of customers resulting in high number of design changes. The objective of this research is to improve the design process of the electric car harness that effects the production scheduling by using Fault Tree Analysis (FTA) and Failure Mode and Effect Analysis (FMEA) as the main tools. FTA is employed for root cause analysis and FMEA is used to ranking a High Risk Priority Number (RPN) which is shows the priority of factors in the electric car harness that have high impact to the design of the electric car harness. After the implementation, the improvements are realized significantly since the number of design change is reduced from 0.26% to 0.08%.

Mainstream upflow nitritation-anammox system with hybrid anaerobic pretreatment: Long-term performance and microbial community dynamics.

PubMed

Li, Xiaojin; Sun, Shan; Yuan, Heyang; Badgley, Brian D; He, Zhen

2017-11-15

Mainstream nitritation-anammox is of strong interest to energy- and resource-efficient domestic wastewater treatment. However, there lack in-depth studies of pretreatment, tests of actual wastewater, and examination of long-term performance. Herein, an upflow nitritation-anammox granular reactor has been investigated to treat primary effluent with a hybrid anaerobic reactor (HAR) as pretreatment for more than 300 days. This system achieved 92% of COD removal, 75% of which was accomplished by the HAR, and had an average final effluent COD concentration of 22 mg L -1 . More than 90% of ammonium was removed in the nitritation-anammox reactor, achieving a nitrogen removal rate of 81.0 g N m -3  d -1 in the last stage. The accumulation of sulfate-reducing bacteria in the HAR evidenced the effect of sulfate on COD removal and subsequent nitrogen removal. Anammox bacteria (predominantly Ca. Jettenia asiatica) accounted for up to 40.2% of total granular communities, but their abundance decreased over time in the suspended communities. The dynamics of major metabolisms and functional genes involved in nitrogen conversion were predicted by PICRUSt based on the taxonomic data, providing more insights into the functions of the microbial communities. These results have demonstrated the effectiveness and importance of anaerobic pretreatment to successful mainstream nitritation-anammox. Copyright © 2017 Elsevier Ltd. All rights reserved.

Harnessing expert knowledge: Defining a Bayesian network decision model with limited data-Model structure for the vibration qualification problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rizzo, Davinia B.; Blackburn, Mark R.

As systems become more complex, systems engineers rely on experts to inform decisions. There are few experts and limited data in many complex new technologies. This challenges systems engineers as they strive to plan activities such as qualification in an environment where technical constraints are coupled with the traditional cost, risk, and schedule constraints. Bayesian network (BN) models provide a framework to aid systems engineers in planning qualification efforts with complex constraints by harnessing expert knowledge and incorporating technical factors. By quantifying causal factors, a BN model can provide data about the risk of implementing a decision supplemented with informationmore » on driving factors. This allows a systems engineer to make informed decisions and examine “what-if” scenarios. This paper discusses a novel process developed to define a BN model structure based primarily on expert knowledge supplemented with extremely limited data (25 data sets or less). The model was developed to aid qualification decisions—specifically to predict the suitability of six degrees of freedom (6DOF) vibration testing for qualification. The process defined the model structure with expert knowledge in an unbiased manner. Finally, validation during the process execution and of the model provided evidence the process may be an effective tool in harnessing expert knowledge for a BN model.« less

Harnessing expert knowledge: Defining a Bayesian network decision model with limited data-Model structure for the vibration qualification problem

DOE PAGES

Rizzo, Davinia B.; Blackburn, Mark R.

2018-03-30

As systems become more complex, systems engineers rely on experts to inform decisions. There are few experts and limited data in many complex new technologies. This challenges systems engineers as they strive to plan activities such as qualification in an environment where technical constraints are coupled with the traditional cost, risk, and schedule constraints. Bayesian network (BN) models provide a framework to aid systems engineers in planning qualification efforts with complex constraints by harnessing expert knowledge and incorporating technical factors. By quantifying causal factors, a BN model can provide data about the risk of implementing a decision supplemented with informationmore » on driving factors. This allows a systems engineer to make informed decisions and examine “what-if” scenarios. This paper discusses a novel process developed to define a BN model structure based primarily on expert knowledge supplemented with extremely limited data (25 data sets or less). The model was developed to aid qualification decisions—specifically to predict the suitability of six degrees of freedom (6DOF) vibration testing for qualification. The process defined the model structure with expert knowledge in an unbiased manner. Finally, validation during the process execution and of the model provided evidence the process may be an effective tool in harnessing expert knowledge for a BN model.« less

Analysis of woven and braided fabric reinforced composites

NASA Technical Reports Server (NTRS)

Naik, Rajiv A.

1994-01-01

A general purpose micromechanics analysis that discretely models the yarn architecture within the textile repeating unit cell, was developed to predict overall, three dimensional, thermal and mechanical properties. This analytical technique was implemented in a user-friendly, personal computer-based, windows compatible code called Textile Composite Analysis for Design (TEXCAD). TEXCAD was used to analyze plain, 5-harness satin, and 8-harness satin weave composites along with 2-D braided and 2x2, 2-D triaxial braided composites. The calculated overall stiffnesses correlated well with available 3-D finite element results and test data for both the woven and the braided composites. Parametric studies were performed to investigate the effects of yarn size on the yarn crimp and the overall thermal and mechanical constants for plain weave composites. The effects of braid angle were investigated for the 2-D braided composites. Finally, the effects of fiber volume fraction on the yarn undulations and the thermal and mechanical properties of 2x2, 2-D triaxial braided composites were also investigated.

Development and Field Test of Task-Based MOS-Specific Criterion Measures. Volume 1. Appendixes A-E

DTIC Science & Technology

1988-04-01

WOUND 081-831-1033 APPLY A DRESSING TO AN OPEN HEAD WOUND 081-831-1005 PREVENT SHOCK 081-831-1034 SPLINT A SUSPECTED FRACTURE 081-831-1007 GTVE FIRST...Check seat belts and shoulder harnesses Check unit vehicle/trailer blackout system Service refrigeration unit Check and clean cab interior/exterior...DRESSING TO AN OPEN HEAD WOUND 081-831-1040 TRANSPORT A CASUALTY USING A ONE MAN CARRY 081-831-1041 TRANSPORT A CASUALTY USING A TWO MAN CARRY OR

A depth video sensor-based life-logging human activity recognition system for elderly care in smart indoor environments.

PubMed

Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

2014-07-02

Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital.

A Depth Video Sensor-Based Life-Logging Human Activity Recognition System for Elderly Care in Smart Indoor Environments

PubMed Central

Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

2014-01-01

Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital. PMID:24991942

Harnessing the Potential of Additive Manufacturing

DTIC Science & Technology

2016-12-01

manufacturing age, which is dominated by standards for materials, processes and process control. Conventional manufacturing is based upon a design that is...documented either in a drawing or a computer-aided design (CAD) file. The manufacturing team then develops a docu- mented public or private process for...31 Defense AT&L: November-December 2016 Harnessing the Potential of Additive Manufacturing Bill Decker Decker is director of Technology

Cooperative fault-tolerant distributed computing U.S. Department of Energy Grant DE-FG02-02ER25537 Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sunderam, Vaidy S.

2007-01-09

The Harness project has developed novel software frameworks for the execution of high-end simulations in a fault-tolerant manner on distributed resources. The H2O subsystem comprises the kernel of the Harness framework, and controls the key functions of resource management across multiple administrative domains, especially issues of access and allocation. It is based on a “pluggable” architecture that enables the aggregated use of distributed heterogeneous resources for high performance computing. The major contributions of the Harness II project result in significantly enhancing the overall computational productivity of high-end scientific applications by enabling robust, failure-resilient computations on cooperatively pooled resource collections.

NEXT Ion Thruster Thermal Model

NASA Technical Reports Server (NTRS)

VanNoord, Jonathan L.

2010-01-01

As the NEXT ion thruster progresses towards higher technology readiness, it is necessary to develop the tools that will support its implementation into flight programs. An ion thruster thermal model has been developed for the latest prototype model design to aid in predicting thruster temperatures for various missions. This model is comprised of two parts. The first part predicts the heating from the discharge plasma for various throttling points based on a discharge chamber plasma model. This model shows, as expected, that the internal heating is strongly correlated with the discharge power. Typically, the internal plasma heating increases with beam current and decreases slightly with beam voltage. The second is a model based on a finite difference thermal code used to predict the thruster temperatures. Both parts of the model will be described in this paper. This model has been correlated with a thermal development test on the NEXT Prototype Model 1 thruster with most predicted component temperatures within 5 to 10 C of test temperatures. The model indicates that heating, and hence current collection, is not based purely on the footprint of the magnet rings, but follows a 0.1:1:2:1 ratio for the cathode-to-conical-to-cylindrical-to-front magnet rings. This thermal model has also been used to predict the temperatures during the worst case mission profile that is anticipated for the thruster. The model predicts ample thermal margin for all of its components except the external cable harness under the hottest anticipated mission scenario. The external cable harness will be re-rated or replaced to meet the predicted environment.

Uneven drive rates of the scanning telescope: Apollo 16 mission

NASA Technical Reports Server (NTRS)

1972-01-01

An investigation was made into the cause or causes of uneven drive rates during operation of the Apollo 16 scanning telescope. It was suggested that such erratic behavior was caused by either changes in the characteristics noise level of the optics counter on the panels or the repositioning process by the computer or zero optics mode. Test results show the anomaly was not caused by either of the above suggestions, instead they were caused by a broken socket spring in the telescope harness. New harnesses will be manufactured for future flights.

Verification and application of the Iosipescu shear test method

NASA Technical Reports Server (NTRS)

Walrath, D. E.; Adams, D. F.

1984-01-01

Finite element models were used to study the effects of notch angle variations on the stress state within an Iosipescu shear test speciment. These analytical results were also studied to determine the feasibility of using strain gage rosettes and a modified extensometer to measure shear strains in this test specimen. Analytical results indicate that notch angle variations produced only small differences in simulated shear properties. Both strain gage rosettes and the modified extensometer were shown to be feasible shear strain transducers for the test method. The Iosipoescu shear test fixture was redesigned to incorporate several improvements. These improvements include accommodation of a 50 percent larger specimen for easier measurement of shear train, a clamping mechanism to relax strict tolerances on specimen width, and a self contained alignment tool for use during specimen installation. A set of in-plane and interlaminar shear properties were measured for three graphite fabric/epoxy composites of T300/934 composite material. The three weave patterns were Oxford, 5-harness satin, and 8-harness satin.

Power Distribution for Cryogenic Instruments at 6-40K The James Webb Space Telescope Case

NASA Technical Reports Server (NTRS)

Rumler, Peter; Lundquist, Ray; Alvarez, Jose Lorenzo; Sincell, Jeff; Tuttle, Jim

2011-01-01

The Integrated Science Instrument Module (ISIM) of the James Webb Space Telescope (JWST) operates its instruments passively cooled at around 40 Kelvin (K), with a warm Instrument Electronic Compartment (IEC) at 300K attached to it. From the warm electronics all secondary signal and power harnesses have to bridge this 300-40K temperature difference and minimize the power dissipation and parasitic heat leak into the cold region. After an introduction of the ISIM with its instruments, the IEC with the electronics, and the harness architecture with a special radiator, this paper elaborates on the cryogenic wire selection and tests performed to establish current de-rating rules for different wire types. Finally failure modes are analyzed for critical instrument interfaces that could inject excessive currents and heat into the harness and cold side, and several solutions for the removal of such failures are presented.

Power Distribution For Cryogenic Instruments At 6-40K The James Webb Space Telescope Case

NASA Astrophysics Data System (ADS)

Rumler, Peter; Lundquist, Ray; Alvarez, Jose Lorenzo; Sincell, Jeff; Tuttle, Jim

2011-10-01

The Integrated Science Instrument Module (ISIM) of the James Webb Space Telescope (JWST) operates its instruments passively cooled at around 40 Kelvin (K), with a warm Instrument Electronic Compartment (IEC) at 300K attached to it. From the warm electronics all secondary signal and power harnesses have to bridge this 300-40K temperature difference and minimize the power dissipation and parasitic heat leak into the cold region. After an introduction of the ISIM with its instruments, the IEC with the electronics, and the harness architecture with a special radiator, this paper elaborates on the cryogenic wire selection and tests performed to establish current de-rating rules for different wire types. Finally failure modes are analyzed for critical instrument interfaces that could inject excessive currents and heat into the harness and cold side, and several solutions for the removal of such failures are presented.

Fibre optics in the SMOS mission

NASA Astrophysics Data System (ADS)

Kudielka, K.; Benito-Hernández, F. J.; Rits, W.; Martin-Neira, M.

2017-11-01

Launched on November 2nd, 2009, SMOS (Soil Moisture, Ocean Salinity) is the second Earth Explorer Opportunity mission developed as part of ESA's Living Planet Programme. It demonstrates a completely new type of instrument - a large, deployable synthetic-aperture microwave radiometer [1]. RUAG Space, Switzerland, as a subcontractor of EADS Astrium, Spain, has provided the instrument's fibreoptic harness, which interconnects the central data processor with all 69 microwave receivers, as well as 12 auxiliary units on board. For reasons explained in Section 3, SMOS is the first European mission extensively using both fibre-optic clock distribution and data transmission in space. In Section 2, we present an overview of the scientific goals of SMOS, and describe the payload's basic function. There from we derive the rationale and the design of the fibre-optic harness (Section 3). In Section 4 all development, manufacturing, and test activities are summarised, which culminated in the successful delivery of all flight units to EADS Astrium by October 2006. We present the major test results obtained with the flight harness (Section 5), and conclude with a short summary of the higher-level activities, which lead to successful launch and commissioning of the SMOS satellite (Section 6).

MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG.

PubMed

Bolduc, David L; Bünger, Rolf; Moroni, Maria; Blakely, William F

2016-12-01

Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create predictive algorithms for estimating the severity of hematopoietic acute radiation syndrome (H-ARS) using two different species (i.e. Göttingen Minipig and non-human primate (NHP) (Macacca mulatta)). Biomarker data were analyzed prior to irradiation and between 1-60 days (minipig) and 1-30 days (NHP) after irradiation exposures of 1.6-3.5 Gy (minipig) and 6.5 Gy (NHP) 60 Co gamma ray doses at 0.5-0.6 Gy min -1 and 0.4 Gy min -1 , respectively. Fitted radiation risk and injury categorization (RRIC) values and RRIC prediction percent accuracies were compared between the two models. Both models estimated H-ARS severity with over 80% overall predictive power and with receiver operating characteristic curve area values of 0.884 and 0.825. These results based on two animal radiation models support the concept for the use of a hematopoietic-based algorithm for predicting the risk of H-ARS in humans. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Correlation of Radiation Dose Estimates by DIC with the METREPOL Hematological Classes of Disease Severity.

PubMed

Port, M; Pieper, B; Dörr, H D; Hübsch, A; Majewski, M; Abend, M

2018-05-01

The degree of severity of hematologic acute radiation syndrome (HARS) may vary across the range of radiation doses, such that dose alone may be a less reliable predictor of clinical course. We sought to elucidate the relationship between absorbed dose and risk of clinically relevant HARS in humans. We used the database SEARCH (System for Evaluation and Archiving of Radiation Accidents based on Case Histories), which contains the histories of radiation accident victims. From 153 cases we extracted data on dose estimates using the dicentric assay to measure individual biological dosimetry. The data were analyzed according to the corresponding hematological response categories of clinical significance (H1-4). These categories are derived from the medical treatment protocols for radiation accident victims (METREPOL) and represent the clinical outcome of HARS based on severity categories ranging from 1-4. In addition, the category H0 represents a post-exposure hematological response that is within the normal range for nonexposed individuals. Age at exposure, gender and ethnicity were considered as potential confounders in unconditional cumulative logistic regression analysis. In most cases, victims were Caucasian (82.4%) and male (92.8%), who originated from either the Chernobyl (69.3%) or Goiânia (10.5%) accident, and nearly 60% were aged 20-40 years at time of exposure. All individuals were whole-body exposed (mean 3.8 Gy, stdev ±3.1), and single exposures were predominantly reported (79%). Seventy percent of victims in category H0 were exposed to ≤1 Gy, with rapidly decreasing proportions of H0 seen at doses up to 5 Gy. There were few HARS H4 cases reported at exposed dose of 1-2 Gy, while 82% of H4 cases received doses of >5 Gy. HARS H1-3 cases varied among dose ranges from 1-5 Gy. In summary, single whole-body radiation doses <1 Gy and >5 Gy corresponded in general with H0 and H3-4, respectively, and this was consistent with medical expectations. This underlines the usefulness of dose estimates for HARS prediction. However, whole-body doses between 1-5 Gy poorly corresponded to HARS H1-3. The dose range of 1-5 Gy was of limited value for medical decision-making regarding, e.g., hospitalization for H2-3, but not H1 and treatment decisions that differ between H1-3. Also, there were some H0 cases at high doses and H2-4 cases at low doses, thereby challenging an individual recommendation based solely on dose.

Many human accelerated regions are developmental enhancers

PubMed Central

Capra, John A.; Erwin, Genevieve D.; McKinsey, Gabriel; Rubenstein, John L. R.; Pollard, Katherine S.

2013-01-01

The genetic changes underlying the dramatic differences in form and function between humans and other primates are largely unknown, although it is clear that gene regulatory changes play an important role. To identify regulatory sequences with potentially human-specific functions, we and others used comparative genomics to find non-coding regions conserved across mammals that have acquired many sequence changes in humans since divergence from chimpanzees. These regions are good candidates for performing human-specific regulatory functions. Here, we analysed the DNA sequence, evolutionary history, histone modifications, chromatin state and transcription factor (TF) binding sites of a combined set of 2649 non-coding human accelerated regions (ncHARs) and predicted that at least 30% of them function as developmental enhancers. We prioritized the predicted ncHAR enhancers using analysis of TF binding site gain and loss, along with the functional annotations and expression patterns of nearby genes. We then tested both the human and chimpanzee sequence for 29 ncHARs in transgenic mice, and found 24 novel developmental enhancers active in both species, 17 of which had very consistent patterns of activity in specific embryonic tissues. Of these ncHAR enhancers, five drove expression patterns suggestive of different activity for the human and chimpanzee sequence at embryonic day 11.5. The changes to human non-coding DNA in these ncHAR enhancers may modify the complex patterns of gene expression necessary for proper development in a human-specific manner and are thus promising candidates for understanding the genetic basis of human-specific biology. PMID:24218637

The Optical Harness: a light-weight EMI-immune replacement for legacy electrical wiring harnesses

NASA Astrophysics Data System (ADS)

Stark, Jason B.; Jackson, B. Scott; Trethewey, William

2006-05-01

Electrical wiring harnesses have been used to interconnect control and communication equipment in mobile platforms for over a century. Although they have served this function successfully, they have three problems that are inherent in their design: they are mechanically heavy and stiff, and they are prone to electrical faults, including arcing and Electro-Magnetic Interference (EMI), and they are difficult to maintain when faults occur. These properties are all aspects of the metallic conductors used to build the harnesses. The Optical Harness TM is a photonic replacement for the legacy electrical wiring harness. The Optical Harness TM uses light-weight optical fiber to replace signal wires in an electrical harness. The original electrical connections to the equipment remain, making the Optical Harness TM a direct replacement for the legacy wiring harness. In the backshell of each connector, the electrical signals are converted to optical, and transported on optical fiber, by a deterministic, redundant and fault-tolerant optical network. The Optical Harness TM: * Provides weight savings of 40-50% and unsurpassed flexibility, relative to legacy signal wiring harnesses; * Carries its signals on optical fiber that is free from arcing, EMI, RFI and susceptibility to HPM weapons; * Is self-monitoring during operation, providing non-intrusive predictive and diagnostic capabilities.

Research study on multi-KW-DC distribution system

NASA Technical Reports Server (NTRS)

Berkery, E. A.; Krausz, A.

1975-01-01

A detailed definition of the HVDC test facility and the equipment required to implement the test program are provided. The basic elements of the test facility are illustrated, and consist of: the power source, conventional and digital supervision and control equipment, power distribution harness and simulated loads. The regulated dc power supplies provide steady-state power up to 36 KW at 120 VDC. Power for simulated line faults will be obtained from two banks of 90 ampere-hour lead-acid batteries. The relative merits of conventional and multiplexed power control will be demonstrated by the Supervision and Monitor Unit (SMU) and the Automatically Controlled Electrical Systems (ACES) hardware. The distribution harness is supported by a metal duct which is bonded to all component structures and functions as the system ground plane. The load banks contain passive resistance and reactance loads, solid state power controllers and active pulse width modulated loads. The HVDC test facility is designed to simulate a power distribution system for large aerospace vehicles.

European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science

DTIC Science & Technology

1988-08-01

problems, and infrastructure and in- terfacing requirements. Development of Finite Element Software for Transputer-Based Parallel Processors ...Introduction will it be possible to harness these processors together to work on a common problem. The feasibility study at the UK’s Kent University for One of...the many problems in harnessing the power development of a distributed supercomputer is being of a large number of processors on a single problem is

Integration of a Copper-Containing Biohybrid (CuHARS) with Cellulose for Subsequent Degradation and Biomedical Control

PubMed Central

Karan, Anik; Darder, Margarita; Kansakar, Urna; Norcross, Zach

2018-01-01

We previously described the novel synthesis of a copper high-aspect ratio structure (CuHARS) biohybrid material using cystine. While extremely stable in water, CuHARS is completely (but slowly) degradable in cellular media. Here, integration of the CuHARS into cellulose matrices was carried out to provide added control for CuHARS degradation. Synthesized CuHARS was concentrated by centrifugation and then dried. The weighed mass was re-suspended in water. CuHARS was stable in water for months without degradation. In contrast, 25 μg/mL of the CuHARS in complete cell culture media was completely degraded (slowly) in 18 days under physiological conditions. Stable integration of CuHARS into cellulose matrices was achieved through assembly by mixing cellulose micro- and nano-fibers and CuHARS in an aqueous (pulp mixture) phase, followed by drying. Additional materials were integrated to make the hybrids magnetically susceptible. The cellulose-CuHARS composite films could be transferred, weighed, and cut into usable pieces; they maintained their form after rehydration in water for at least 7 days and were compatible with cell culture studies using brain tumor (glioma) cells. These studies demonstrate utility of a CuHARS-cellulose biohybrid for applied applications including: (1) a platform for biomedical tracking and (2) integration into a 2D/3D matrix using natural products (cellulose). PMID:29693569

KSC-07pd2606

NASA Image and Video Library

2007-09-28

KENNEDY SPACE CENTER, FLA. -- Astronaut Leopold Eyharts, who represents the European Space Agency, tries on a harness in the Orbiter Processing Facility. Eyharts will be traveling to the International Space Station to join the Expedition 16 crew as a flight engineer. The crew is at Kennedy to take part in a crew equipment interface test, or CEIT, which helps familiarize them with equipment and payloads for the mission. Among the activities standard to a CEIT are harness training, inspection of the thermal protection system and camera operation for planned extravehicular activities, or EVAs. STS-122 is targeted for launch in December. Photo credit: NASA/Kim Shiflett

KSC-07pd2605

NASA Image and Video Library

2007-09-28

KENNEDY SPACE CENTER, FLA. -- Members of the STS-122 crew take part in harness training in the Orbiter Processing Facility at NASA's Kennedy Space Center. Seen from left are Mission Specialists Stanley Love and Leland Melvin and Pilot Alan Poindexter. The crew is at Kennedy to take part in a crew equipment interface test, or CEIT, which helps familiarize them with equipment and payloads for the mission. Among the activities standard to a CEIT are harness training, inspection of the thermal protection system and camera operation for planned extravehicular activities, or EVAs. STS-122 is targeted for launch in December. Photo credit: NASA/Kim Shiflett

Feature selection for wearable smartphone-based human activity recognition with able bodied, elderly, and stroke patients.

PubMed

Capela, Nicole A; Lemaire, Edward D; Baddour, Natalie

2015-01-01

Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations.

Feature Selection for Wearable Smartphone-Based Human Activity Recognition with Able bodied, Elderly, and Stroke Patients

PubMed Central

2015-01-01

Human activity recognition (HAR), using wearable sensors, is a growing area with the potential to provide valuable information on patient mobility to rehabilitation specialists. Smartphones with accelerometer and gyroscope sensors are a convenient, minimally invasive, and low cost approach for mobility monitoring. HAR systems typically pre-process raw signals, segment the signals, and then extract features to be used in a classifier. Feature selection is a crucial step in the process to reduce potentially large data dimensionality and provide viable parameters to enable activity classification. Most HAR systems are customized to an individual research group, including a unique data set, classes, algorithms, and signal features. These data sets are obtained predominantly from able-bodied participants. In this paper, smartphone accelerometer and gyroscope sensor data were collected from populations that can benefit from human activity recognition: able-bodied, elderly, and stroke patients. Data from a consecutive sequence of 41 mobility tasks (18 different tasks) were collected for a total of 44 participants. Seventy-six signal features were calculated and subsets of these features were selected using three filter-based, classifier-independent, feature selection methods (Relief-F, Correlation-based Feature Selection, Fast Correlation Based Filter). The feature subsets were then evaluated using three generic classifiers (Naïve Bayes, Support Vector Machine, j48 Decision Tree). Common features were identified for all three populations, although the stroke population subset had some differences from both able-bodied and elderly sets. Evaluation with the three classifiers showed that the feature subsets produced similar or better accuracies than classification with the entire feature set. Therefore, since these feature subsets are classifier-independent, they should be useful for developing and improving HAR systems across and within populations. PMID:25885272

75 FR 63422 - Airworthiness Directives; Embraer-Empresa Brasileira de Aeronautica S.A. Model EMB-500 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... chafing between the same harness and the oxygen tubing. The chafing of the wiring harness against the oxygen tubing could lead to a short circuit of the wiring harness and a subsequent fire in the airplane... harness and the oxygen tubing. The chafing of the wiring harness against the oxygen tubing could lead to a...

Quick-disconnect harness system for helmet-mounted displays

NASA Astrophysics Data System (ADS)

Bapu, P. T.; Aulds, M. J.; Fuchs, Steven P.; McCormick, David M.

1992-10-01

We have designed a pilot's harness-mounted, high voltage quick-disconnect connectors with 62 pins, to transmit voltages up to 13.5 kV and video signals with 70 MHz bandwidth, for a binocular helmet-mounted display system. It connects and disconnects with power off, and disconnects 'hot' without pilot intervention and without producing external sparks or exposing hot embers to the explosive cockpit environment. We have implemented a procedure in which the high voltage pins disconnect inside a hermetically-sealed unit before the physical separation of the connector. The 'hot' separation triggers a crowbar circuit in the high voltage power supplies for additional protection. Conductor locations and shields are designed to reduce capacitance in the circuit and avoid crosstalk among adjacent circuits. The quick- disconnect connector and wiring harness are human-engineered to ensure pilot safety and mobility. The connector backshell is equipped with two hybrid video amplifiers to improve the clarity of the video signals. Shielded wires and coaxial cables are molded as a multi-layered ribbon for maximum flexibility between the pilot's harness and helmet. Stiff cabling is provided between the quick-disconnect connector and the aircraft console to control behavior during seat ejection. The components of the system have been successfully tested for safety, performance, ergonomic considerations, and reliability.

EMPReSS: European mouse phenotyping resource for standardized screens.

PubMed

Green, Eain C J; Gkoutos, Georgios V; Lad, Heena V; Blake, Andrew; Weekes, Joseph; Hancock, John M

2005-06-15

Standardized phenotyping protocols are essential for the characterization of phenotypes so that results are comparable between different laboratories and phenotypic data can be related to ontological descriptions in an automated manner. We describe a web-based resource for the visualization, searching and downloading of standard operating procedures and other documents, the European Mouse Phenotyping Resource for Standardized Screens-EMPReSS. Direct access: http://www.empress.har.mrc.ac.uk e.green@har.mrc.ac.uk.

Stress polishing demonstrator for ELT M1 segments and industrialization

NASA Astrophysics Data System (ADS)

Hugot, Emmanuel; Bernard, Anaïs.; Laslandes, Marie; Floriot, Johan; Dufour, Thibaut; Fappani, Denis; Combes, Jean Marc; Ferrari, Marc

2014-07-01

After two years of research and development under ESO support, LAM and Thales SESO present the results of their experiment for the fast and accurate polishing under stress of ELT 1.5 meter segments as well as the industrialization approach for mass production. Based on stress polishing, this manufacturing method requires the conception of a warping harness able to generate extremely accurate bending of the optical surface of the segments during the polishing. The conception of the warping harness is based on finite element analysis and allowed a fine tuning of each geometrical parameter of the system in order to fit an error budget of 25nm RMS over 300μm of bending peak to valley. The optimisation approach uses the simulated influence functions to extract the system eigenmodes and characterise the performance. The same approach is used for the full characterisation of the system itself. The warping harness has been manufactured, integrated and assembled with the Zerodur 1.5 meter segment on the LAM 2.5meter POLARIS polishing facility. The experiment consists in a cross check of optical and mechanical measurements of the mirrors bending in order to develop a blind process, ie to bypass the optical measurement during the final industrial process. This article describes the optical and mechanical measurements, the influence functions and eigenmodes of the system and the full performance characterisation of the warping harness.

The effects of gait training with body weight support (BWS) with no body weight support (no-BWS) in stroke patients.

PubMed

Ullah, Muhammad Asad; Shafi, Hina; Khan, Ghazanfar Ali; Malik, Arshad Nawaz; Amjad, Imran

2017-07-01

The purpose of this study was to measure the clinical outcomes for patients with stroke after gait training with body weight support (BWS) and with no body weight support (no-BWS).Experimental group was trained to walk by a BWS system with overhead harness (BWS group), and Control group was trained with full weight bearing walk on their lower extremities. Treatment session comprised of six weeks training. Treatment outcomes were assessed on the basis of Timed 10 Meter Walk Test, Timed Get Up and Go Test and Dynamic Gait Index. There was a significant (P<0.05) difference in BWS and NBWS for Dynamic Gait Index, Timed Get Up and Go Test, Timed 10 Meter Walk Test (Self-Selected Velocity), and Timed 10 Meter Walk Test (Fast-Velocity). Training of gait in stroke patients while a percentage of their body weight supported by a harness, resulted in better walking abilities than the Training of gait while full weight was placed on patient's lower extremities.

Trunk Muscle Activation and Estimating Spinal Compressive Force in Rope and Harness Vertical Dance.

PubMed

Wilson, Margaret; Dai, Boyi; Zhu, Qin; Humphrey, Neil

2015-12-01

Rope and harness vertical dance takes place off the floor with the dancer suspended from his or her center of mass in a harness attached to a rope from a point overhead. Vertical dance represents a novel environment for training and performing in which expected stresses on the dancer's body are different from those that take place during dance on the floor. Two male and eleven female dancers with training in vertical dance performed six typical vertical dance movements with electromyography (EMG) electrodes placed bilaterally on rectus abdominus, external oblique, erector spinae, and latissimus dorsi. EMG data were expressed as a percentage of maximum voluntary isometric contraction (MVIC). A simplified musculoskeletal model based on muscle activation for these four muscle groups was used to estimate the compressive force on the spine. The greatest muscle activation for erector spinae and latissimus dorsi and the greatest trunk compressive forces were seen in vertical axis positions where the dancer was moving the trunk into a hyper-extended position. The greatest muscle activation for rectus abdominus and external oblique and the second highest compressive force were seen in a supine position with the arms and legs extended away from the center of mass (COM). The least muscle activation occurred in positions where the limbs were hanging below the torso. These movements also showed relatively low muscle activation compression forces. Post-test survey results revealed that dancers felt comfortable in these positions; however, observation of some positions indicated insufficient muscular control. Computing the relative contribution of muscles, expressed as muscle activation and estimated spinal compression, provided a measure of how much the muscle groups were working to support the spine and the rest of the dancer's body in the different movements tested. Additionally, identifying typical muscle recruitment patterns in each movement will help identify key exercises for training that should promote injury prevention.

Design, development, manufacture, testing, and delivery of devices for connection of solar cell panel circuitry to flat conductor cable solar cell array harness

NASA Technical Reports Server (NTRS)

Dillard, P. A.; Waddington, D.

1971-01-01

The technology status and problem areas which exist for the application of flat conductor cabling to solar cell arrays are summarized. Details covering the design, connector manufacture, and prototype test results are also summarized.

Space Environment Testing of Photovoltaic Array Systems

NASA Technical Reports Server (NTRS)

Phillips, Brandon; Schneider, Todd A.; Vaughn, Jason A.; Wright, Kenneth H.

2015-01-01

To successfully operate a photovoltaic (PV) array system in space requires planning and testing to account for the effects of the space environment. It is critical to understand space environment interactions not only on the PV components, but also the array substrate materials, wiring harnesses, connectors, and protection circuitry.

Concept of internal structural controls for evaluation of inactive synthetic peptide analogs: synthesis of [Orn13,14]apamin and its guanidination to an apamin derivative with full neurotoxic activity.

PubMed Central

Cosand, W L; Merrifield, R B

1977-01-01

The importance of arginine residues 13 and 14 in the bee venom neurotoxin, apamin, was teste by the synthesis of replacement analogs. [13,14-di-Ndelta-trifluoroacetylornithine]Apamin was synthesized by the solid phase method on a benzhydrylamine resin. It was deprotected to [13,14-diornithine]apamin, which was then guanidinated to produce the 4-homoarginine-13,14-diarginine analog, [Har4]apamin. Neither the trifluoroacetylornithine analog nor the ornithine analog produced any detectable symptoms when injected intravenously into mice. However, the synthetic [Har4]apamin exhibited the full neurotoxic activity of native apamin and of [Har4]apamin derived from the natural toxin. This provided an internal structural control for the correctness of the primary structure of the inactive synthetic analogs and strengthened the conclusion that one, or both, of the arginine residues plays an important role in the action of apamin. Images PMID:268626

OSIRIS-REx Visible And Infrared Spectrometer - OVIRS

NASA Technical Reports Server (NTRS)

Hair, Jason

2016-01-01

Goddard Space Flight Center: Overall Instrument Responsibility; Instrument Scientist and Deputy Instrument Scientist; Management Systems Engineering; Mechanical Hardware; Harness Assemblies; SIDECAR Assembly Code; OVIRS Integration and Environmental Qualification; OVIRS Performance Testing, Calibration and Characterization.

Negative Rotation Cinch Strap.

DTIC Science & Technology

This project discloses an improved unitary parachute torso harness, having a single fastening means, wherein an auxillary tightening strap is...attached to the groin straps of said harness. Said auxillary straps are used to prevent torso rotation or harness slippage and to prevent harness elongation

Moving Large Wiring-Harness Boards

NASA Technical Reports Server (NTRS)

Shepherd, Samuel D.; Gurman, Isaac

1990-01-01

Carrier for wiring-harness fabrication boards enables lone operator to move board easily and safely. Holds harness while operator fabricating, while being stored, and being transported to equipment frame for mounting. When positioned for assembly of wiring harness, board and carrier give operator easy and convenient access to wires and cables, when positioned for transfer of wiring harness to or from storage area, carrier holds board securely while moved by one person.

Quality of harness fit for normal and low birthweight infants observed among newborns in infant car seats.

PubMed

Brown, Julie; Sinn, John Kam Hung; Chua, Aileen; Clarke, Elizabeth Clare

2017-04-01

Child restraint fit is important for crash protection. For newborns, standards universally require a rear-facing restraint and some upper limit on size, but historically there has been no specification of a lower design limit and there is concern over whether low birthweight infants (LBW) are adequately restrained. The aim of this study was to determine the quality of harness fit for newborns of low and normal weight in a range of modern child restraints. A convenience sample of infants (1.657-4.455 kg) were recruited from the postnatal ward and special care nursery <1 week from discharge. Infants (n=84) were assessed for harness fit in rear-facing-only restraints, convertible rear/forward restraints and a subset were assessed in a restraint specifically designed to accommodate LBW infants. Measures of harness fit were based on shoulder strap, crotch strap and buckle positioning. Less than 20% of infants achieved good harness fit, regardless of whether they were categorised as low (<2.5 kg) or normal weight. Rear-facing-only restraints were less likely to provide good fit than convertible restraints, in all measures of fit other than shoulder strap width. The proportions of infants achieving good fit were greater in the restraint designed for LBW infants than other restraint types. Poor accommodation continues to be a problem for LBW infants but is rectified in specifically designed restraints. Better specification of harness configuration for all rearward-facing restraints may be required to ensure adequate accommodation of normal birthweight infants. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

ASCAN Helms with instructor during Elgin AFB water survival training

NASA Technical Reports Server (NTRS)

1990-01-01

1990 Group 13 Astronaut Candidate (ASCAN) Susan J. Helms, wearing helmet with oxygen mask and inflated life jacket, is assisted by training instructor during water survival exercises at Elgin Air Force Base (AFB) in Pensacola, Florida. Helms looks on as the instructor adjusts her parachute harness. When ready, Helms will be dropped from the harness into the pool (in background) to simulate a water landing after T-38 ejection. ASCANs participated in the exercises from 08-14-90 through 08-17-90.

ASCAN Helms with instructor during Elgin AFB water survival training

NASA Image and Video Library

1990-09-20

1990 Group 13 Astronaut Candidate (ASCAN) Susan J. Helms, wearing helmet with oxygen mask and inflated life jacket, is assisted by training instructor during water survival exercises at Elgin Air Force Base (AFB) in Pensacola, Florida. Helms looks on as the instructor adjusts her parachute harness. When ready, Helms will be dropped from the harness into the pool (in background) to simulate a water landing after T-38 ejection. ASCANs participated in the exercises from 08-14-90 through 08-17-90.

Features of the solar array drive mechanism for the space telescope

NASA Technical Reports Server (NTRS)

Hostenkamp, R. G.

1985-01-01

The solar array drive mechanism for the Space Telescope embodies several features not customarily found on solar array drives. Power and signal transfer is achieved by means of a flexible wire harness for which the chosen solution, consisting of 168 standard wires, is described. The torque performance data of the harness over its temperature range are presented. The off load system which protects the bearings from the launch loads is released by a trigger made from Nitinol, the memory alloy. The benefits of memory alloy and the caveats for the design are briefly discussed. The design of the off load system is described and test experience is reported.

Guidance for Performing Tests on Dredged Material Proposed for Ocean Disposal at the Historic Area Remediation Site

EPA Pesticide Factsheets

Guidance presents the sediment testing guidelines and requirements to be used by applicants who wish to obtain a Department of the Army permit from the USACE-New York District for dredging and placement of dredged material at the HARS in the Atlantic Ocean

14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... combination of structural analysis and static load tests to limit load; or (3) Static load tests to ultimate... OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY... resulting from the ultimate static load factors prescribed in § 23.561(b)(2) of this part. Each occupant...

14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... combination of structural analysis and static load tests to limit load; or (3) Static load tests to ultimate... OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY... resulting from the ultimate static load factors prescribed in § 23.561(b)(2) of this part. Each occupant...

14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... combination of structural analysis and static load tests to limit load; or (3) Static load tests to ultimate... OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY... resulting from the ultimate static load factors prescribed in § 23.561(b)(2) of this part. Each occupant...

14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... combination of structural analysis and static load tests to limit load; or (3) Static load tests to ultimate... OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY... resulting from the ultimate static load factors prescribed in § 23.561(b)(2) of this part. Each occupant...

14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... combination of structural analysis and static load tests to limit load; or (3) Static load tests to ultimate... OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY... resulting from the ultimate static load factors prescribed in § 23.561(b)(2) of this part. Each occupant...

Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.

PubMed

Chua, Hui Lin; Plett, P Artur; Sampson, Carol H; Katz, Barry P; Carnathan, Gilbert W; MacVittie, Thomas J; Lenden, Keith; Orschell, Christie M

2014-01-01

In an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS), along with the lead MCM for licensure and stockpiling, G-CSF. Both PEG-G-CSFs were shown to retain significant survival efficacy when administered as a single dose 24 h post-exposure, compared to the 16 daily doses of G-CSF required for survival efficacy. Furthermore, 0.1 mg kg of either PEG-G-CSF affected survival of lethally-irradiated mice that was similar to a 10-fold higher dose. The one dose/low dose administration schedules are attractive attributes of radiation MCM given the logistical challenges of medical care in a mass casualty event. Maxy-G34-treated mice that survived H-ARS were examined for residual bone marrow damage (RBMD) up to 9 mo post-exposure. Despite differences in Sca-1 expression and cell cycle position in some hematopoietic progenitor phenotypes, Maxy-G34-treated mice exhibited the same degree of hematopoietic stem cell (HSC) insufficiency as vehicle-treated H-ARS survivors in competitive transplantation assays of 150 purified Sca-1+cKit+lin-CD150+cells. These data suggest that Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy-G34, as well as Neulasta, as MCM against radiation.

Relative prevalence of upper respiratory tract obstructive disorders in two breeds of harness racehorses (185 cases: 1998-2006).

PubMed

Strand, E; Fjordbakk, C T; Sundberg, K; Spangen, L; Lunde, H; Hanche-Olsen, S

2012-09-01

Two genetically and phenotypically distinct horse breeds are used for harness racing in Scandinavia: the Standardbred (SB) and Coldblooded Trotter. These racehorses have identical environmental, management and racing conditions. Therefore, this study was undertaken to identify and compare the relative prevalence of upper respiratory tract (URT) obstructive disorders in these 2 breeds. To determine whether these 2 phenotypically different breeds of harness racehorses have different predispositions for URT disorders. Retrospective study of 88 Norwegian Coldblooded Trotters (NCT) and 97 SBs referred to this hospital for URT evaluation between 1998 and 2006. Case records of all horses diagnosed with an URT disorder during resting endoscopy, and all horses undergoing high-speed treadmill videoendoscopy (HSTV) with one or more periods of induced poll flexion were evaluated. The relative prevalence of URT disorders between the 2 breeds was analysed using a Fisher's exact test. There was a significant (P<0.05) breed predisposition regarding 6 URT disorders. Bilateral dynamic laryngeal collapse associated with poll flexion and flaccid epiglottis was significantly more frequent in the NCT. Alar fold collapse and nasopharyngeal collapse were significantly more frequent in SBs. Epiglottic entrapment and nasal flutter were only diagnosed in the SBs. Dynamic disorders were more common than resting disorders in both breeds. URT obstructive disorders (dynamic laryngeal collapse associated with poll flexion, flaccid epiglottis, pharyngeal collapse, alar fold collapse, nasal flutter and epiglottic entrapment) are breed related, indicating an anatomic or functional cause. Periods of induced poll flexion during HSTV was essential to declare harness racehorses free of URT disorders. Further anatomic or physiological studies comparing these breeds could potentially provide insight into the pathogenesis of certain URT obstructive disorders. Induced poll flexion should be included in routine HSTV examinations of all harness racehorses. © 2011 EVJ Ltd.

14 CFR 125.211 - Seat and safety belts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... emergency exit. (f) Each occupant of a seat equipped with a shoulder harness must fasten the shoulder harness during takeoff and landing, except that, in the case of crewmembers, the shoulder harness need not be fastened if the crewmember cannot perform his required duties with the shoulder harness fastened...

CUDA-based real time surgery simulation.

PubMed

Liu, Youquan; De, Suvranu

2008-01-01

In this paper we present a general software platform that enables real time surgery simulation on the newly available compute unified device architecture (CUDA)from NVIDIA. CUDA-enabled GPUs harness the power of 128 processors which allow data parallel computations. Compared to the previous GPGPU, it is significantly more flexible with a C language interface. We report implementation of both collision detection and consequent deformation computation algorithms. Our test results indicate that the CUDA enables a twenty times speedup for collision detection and about fifteen times speedup for deformation computation on an Intel Core 2 Quad 2.66 GHz machine with GeForce 8800 GTX.

Quinoa - Adaptive Computational Fluid Dynamics, 0.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bakosi, Jozsef; Gonzalez, Francisco; Rogers, Brandon

Quinoa is a set of computational tools that enables research and numerical analysis in fluid dynamics. At this time it remains a test-bed to experiment with various algorithms using fully asynchronous runtime systems. Currently, Quinoa consists of the following tools: (1) Walker, a numerical integrator for systems of stochastic differential equations in time. It is a mathematical tool to analyze and design the behavior of stochastic differential equations. It allows the estimation of arbitrary coupled statistics and probability density functions and is currently used for the design of statistical moment approximations for multiple mixing materials in variable-density turbulence. (2) Inciter,more » an overdecomposition-aware finite element field solver for partial differential equations using 3D unstructured grids. Inciter is used to research asynchronous mesh-based algorithms and to experiment with coupling asynchronous to bulk-synchronous parallel code. Two planned new features of Inciter, compared to the previous release (LA-CC-16-015), to be implemented in 2017, are (a) a simple Navier-Stokes solver for ideal single-material compressible gases, and (b) solution-adaptive mesh refinement (AMR), which enables dynamically concentrating compute resources to regions with interesting physics. Using the NS-AMR problem we plan to explore how to scale such high-load-imbalance simulations, representative of large production multiphysics codes, to very large problems on very large computers using an asynchronous runtime system. (3) RNGTest, a test harness to subject random number generators to stringent statistical tests enabling quantitative ranking with respect to their quality and computational cost. (4) UnitTest, a unit test harness, running hundreds of tests per second, capable of testing serial, synchronous, and asynchronous functions. (5) MeshConv, a mesh file converter that can be used to convert 3D tetrahedron meshes from and to either of the following formats: Gmsh, (http://www.geuz.org/gmsh), Netgen, (http://sourceforge.net/apps/mediawiki/netgen-mesher), ExodusII, (http://sourceforge.net/projects/exodusii), HyperMesh, (http://www.altairhyperworks.com/product/HyperMesh).« less

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Fastening of safety belts and shoulder... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No... belt and shoulder harness properly secured about that person except that the shoulder harness need not...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Seats, safety belts, and shoulder harnesses... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless... belt and shoulder harness that meets the applicable requirements specified in § 25.785 of this chapter...

Harnessing Protocolized Adaptation in Dissemination: Successful Implementation and Sustainment of the Veterans Affairs Coordinated-Transitional Care Program in a Non-Veterans Affairs Hospital.

PubMed

Kind, Amy J H; Brenny-Fitzpatrick, Maria; Leahy-Gross, Kris; Mirr, Jacquelyn; Chapman, Elizabeth; Frey, Brooke; Houlahan, Beth

2016-02-01

The Department of Veterans Affairs (VA) Coordinated-Transitional Care (C-TraC) program is a low-cost transitional care program that uses hospital-based nurse case managers, inpatient team integration, and in-depth posthospital telephone contacts to support high-risk patients and their caregivers as they transition from hospital to community. The low-cost, primarily telephone-based C-TraC program reduced 30-day rehospitalizations by one-third, leading to significant cost savings at one VA hospital. Non-VA hospitals have expressed interest in launching C-TraC, but non-VA hospitals differ in important ways from VA hospitals, particularly in terms of context, culture, and resources. The objective of this project was to adapt C-TraC to the specific context of one non-VA setting using a modified Replicating Effective Programs (REP) implementation theory model and to test the feasibility of this protocolized implementation approach. The modified REP model uses a mentored phased-based implementation with intensive preimplementation activities and harnesses key local stakeholders to adapt processes and goals to local context. Using this protocolized implementation approach, an adapted C-TraC protocol was created and launched at the non-VA hospital in July 2013. In its first 16 months, C-TraC successfully enrolled 1,247 individuals with 3.2 full-time nurse case managers, achieving good fidelity for core protocol steps. C-TraC participants experienced a 30-day rehospitalization rate of 10.8%, compared with 16.6% for a contemporary comparison group of similar individuals for whom C-TraC was not available (n = 1,307) (P < .001). The new C-TraC program continues in operation. Use of a modified REP model to guide protocolized adaptation to local context resulted in a C-TraC program that was feasible and sustained in a real-world non-VA setting. A modified REP implementation framework may be an appropriate foundational step for other clinical programs seeking to harness protocolized adaptation in mentored dissemination activities. © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

Harnessing complexity: taking advantage of context and relationships in dissemination of school-based interventions.

PubMed

Butler, Helen; Bowes, Glenn; Drew, Sarah; Glover, Sara; Godfrey, Celia; Patton, George; Trafford, Lea; Bond, Lyndal

2010-03-01

Schools and school systems are increasingly asked to use evidence-based strategies to promote the health and well-being of students. The dissemination of school-based health promotion research, however, offers particular challenges to conventional approaches to dissemination. Schools and education systems are multifaceted organizations that sit within constantly shifting broader contexts. This article argues that health promotion dissemination needs to be rethought for school communities as complex systems and that this requires understanding and harnessing the dynamic ecology of the sociopolitical context. In developing this argument, the authors draw on their experience of the dissemination process of a multilevel school-based intervention in a complex educational context. Building on this experience, they argue for the need to move beyond conventional dissemination strategies to a focus on active partnerships between developers and users of school-based intervention research and offer a conceptual tool for planning dissemination.

On the usage of classical nucleation theory in predicting the impact of bacteria on weather and climate

NASA Astrophysics Data System (ADS)

Sahyoun, Maher; Woetmann Nielsen, Niels; Havskov Sørensen, Jens; Finster, Kai; Bay Gosewinkel Karlson, Ulrich; Šantl-Temkiv, Tina; Smith Korsholm, Ulrik

2014-05-01

Bacteria, e.g. Pseudomonas syringae, have previously been found efficient in nucleating ice heterogeneously at temperatures close to -2°C in laboratory tests. Therefore, ice nucleation active (INA) bacteria may be involved in the formation of precipitation in mixed phase clouds, and could potentially influence weather and climate. Investigations into the impact of INA bacteria on climate have shown that emissions were too low to significantly impact the climate (Hoose et al., 2010). The goal of this study is to clarify the reason for finding the marginal impact on climate when INA bacteria were considered, by investigating the usability of ice nucleation rate parameterization based on classical nucleation theory (CNT). For this purpose, two parameterizations of heterogeneous ice nucleation were compared. Both parameterizations were implemented and tested in a 1-d version of the operational weather model (HIRLAM) (Lynch et al., 2000; Unden et al., 2002) in two different meteorological cases. The first parameterization is based on CNT and denoted CH08 (Chen et al., 2008). This parameterization is a function of temperature and the size of the IN. The second parameterization, denoted HAR13, was derived from nucleation measurements of SnomaxTM (Hartmann et al., 2013). It is a function of temperature and the number of protein complexes on the outer membranes of the cell. The fraction of cloud droplets containing each type of IN as percentage in the cloud droplets population were used and the sensitivity of cloud ice production in each parameterization was compared. In this study, HAR13 produces more cloud ice and precipitation than CH08 when the bacteria fraction increases. In CH08, the increase of the bacteria fraction leads to decreasing the cloud ice mixing ratio. The ice production using HAR13 was found to be more sensitive to the change of the bacterial fraction than CH08 which did not show a similar sensitivity. As a result, this may explain the marginal impact of IN bacteria in climate models when CH08 was used. The number of cell fragments containing proteins appears to be a more important parameter to consider than the size of the cell when parameterizing the heterogeneous freezing of bacteria.

Biological Moleculars: Have Most of Our Problems Already Been Solved?

NASA Technical Reports Server (NTRS)

Downey, James P.; Rose, M. Franklin (Technical Monitor)

2000-01-01

Evolution has resulted in biological machinery that engineers have great reason to envy and at present can only poorly mimic. This is not just a curiosity as biological systems perform many functions that are desired industrial processes. Examples include photosynthesis, chemosynthesis, energy storage, low temperature chemical conversion, reproducible manufacture of chemical compounds, etc. The bases of biological machinery are the proteins and nucleic acids that comprise living organisms. Each molecule functions as a part of a biological machine. In many cases the molecule can be properly regarded as a stand alone machine of its own. Concepts and methods for harnessing the power of biological molecules exist but are often overlooked in the industrial world. Some are old and appear crude but are quite effective, e.g. the fermentation of grains and fruits. Currently, there is a revolution in progress regarding the harnessing biological processes. These include techniques such as genetic manipulation via polymerase chain reaction, forced evolution also known as evolution in a test tube, determination of molecular structure, and combinatorial chemistry. The following is a brief discussion on how these processes are performed and how they may relate to industrial and aerospace processes.

78 FR 14442 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... certain serial number (S/N) N2 sensor harnesses. This AD requires replacement of the same S/N harnesses, and requires replacement of additional S/N N2 sensor harnesses. This AD was prompted by corrosion detected in affected N2 sensor harnesses. We are issuing this AD to prevent inadvertent activation of the...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... fasten and unfasten that person's safety belt and, if installed, shoulder harness. (2) No pilot may cause...

Registration of two double rust resistant germplasms, HA-R12 and HA-R13 for confection sunflower

USDA-ARS?s Scientific Manuscript database

The confection sunflower (Helianthus annuus L.) germplasms HA-R12 (Reg. No. ______, PI 673104) and HA-R13 (Reg. No. ______, PI 673105) were developed by the USDA-ARS, Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station, and released in Jul...

Registration of two confection sunflower germplasm Lines, HA-R10 and HA-R11, Resistant to sunflower rust

USDA-ARS?s Scientific Manuscript database

Two confection sunflower (Helianthus annuus L.) germplasm lines, HA-R10 (Reg. No.xxx, PI670043) and HA-R11 (Reg. No.xxx, PI670044) were developed by the USDA-ARS Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station and released December, 20...

Engineering antigen-specific immunological tolerance.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kontos, Stephan; Grimm, Alizee J.; Hubbell, Jeffrey A.

2015-05-01

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigenspecific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatorymore » responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.« less

Positioning bars for large wire harnesses

NASA Technical Reports Server (NTRS)

Glessner, J. R.

1978-01-01

By tying positioning bars to harness, its configuration can be preserved during transport, thus facilitating installation. Harness can also be showed temporarily by placing hanging hooks on end of bar.

Hepatic Artery Resection for Bismuth Type III and IV Hilar Cholangiocarcinoma: Is Reconstruction Always Required?

PubMed

Hu, Hai-Jie; Jin, Yan-Wen; Zhou, Rong-Xing; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Wang, Jun-Ke; Liu, Fei; Cheng, Nan-Sheng; Li, Fu-Yu

2018-03-06

The objective of the study is to examine the feasibility of hepatic artery resection (HAR) without subsequent reconstruction (RCS) in specified patients of Bismuth type III and IV hilar cholangiocarcinoma. We retrospectively reviewed 63 patients who underwent hepatic artery resection for Bismuth type III and IV hilar cholangiocarcinoma. These patients were subsequently enrolled into two groups based on whether the artery reconstruction was conducted. Postoperative morbidity and mortality, and long-term survival outcome were compared between the two groups. There were 29 patients in HAR group and 34 patients in the HAR + RCS group. Patients with hepatic artery reconstruction tended to have longer operative time (545.6 ± 143.1 min vs. 656.3 ± 192.8 min; P = 0.013) and smaller tumor size (3.0 ± 1.1 cm vs. 2.5 ± 0.9 cm; P = 0.036). The R0 resection margin was comparable between the HAR group and HAR + RCS group (86.2 vs. 85.3%; P > 0.05). Twelve patients (41.4%) with 24 complications in HAR group and 13 patients (38.2%) with 25 complications in HAR + RCS group were recorded (P = 0.799). The postoperative hepatic failure rate (13.8 vs. 5.9%) and postoperative mortality rate (3.4% vs. 2.9%) were also comparable between the two groups. In the HAR group, the overall 1-, 3-, and 5-year survival rates were 72, 41, and 19%, respectively; while in the HAR + RCS group, the overall 1-, 3-, and 5-year survival rates were 79, 45, and 25%, respectively (P = 0.928). Hepatic artery resection without reconstruction is also a safe and feasible surgical procedure for highly selected cases of Bismuth type III and IV hilar cholangiocarcinoma.

KSC-07pd3631

NASA Image and Video Library

2007-12-14

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A, a technician explains how test equipment -- the blue monitor -- will be used to validate the circuit on test wiring from the electrical harness in space shuttle Atlantis' aft main engine compartment connected with the engine cut-off system. The test wiring leads from the tail mast on the mobile launcher platform to the interior where the Time Domain Reflectometry, or TDR, test equipment will be located to test the sensor system. Photo credit: NASA/Kim Shiflett

Genomic and Network Patterns of Schizophrenia Genetic Variation in Human Evolutionary Accelerated Regions

PubMed Central

Xu, Ke; Schadt, Eric E.; Pollard, Katherine S.; Roussos, Panos; Dudley, Joel T.

2015-01-01

The population persistence of schizophrenia despite associated reductions in fitness and fecundity suggests that the genetic basis of schizophrenia has a complex evolutionary history. A recent meta-analysis of schizophrenia genome-wide association studies offers novel opportunities for assessment of the evolutionary trajectories of schizophrenia-associated loci. In this study, we hypothesize that components of the genetic architecture of schizophrenia are attributable to human lineage-specific evolution. Our results suggest that schizophrenia-associated loci enrich in genes near previously identified human accelerated regions (HARs). Specifically, we find that genes near HARs conserved in nonhuman primates (pHARs) are enriched for schizophrenia-associated loci, and that pHAR-associated schizophrenia genes are under stronger selective pressure than other schizophrenia genes and other pHAR-associated genes. We further evaluate pHAR-associated schizophrenia genes in regulatory network contexts to investigate associated molecular functions and mechanisms. We find that pHAR-associated schizophrenia genes significantly enrich in a GABA-related coexpression module that was previously found to be differentially regulated in schizophrenia affected individuals versus healthy controls. In another two independent networks constructed from gene expression profiles from prefrontal cortex samples, we find that pHAR-associated schizophrenia genes are located in more central positions and their average path lengths to the other nodes are significantly shorter than those of other schizophrenia genes. Together, our results suggest that HARs are associated with potentially important functional roles in the genetic architecture of schizophrenia. PMID:25681384

Measuring Rind Thickness on Polyurethane Foam

NASA Technical Reports Server (NTRS)

Johnson, C.; Miller, J.; Brown, H.

1985-01-01

Nondestructive test determines rind thickness of polyurethane foam. Surface harness of foam measured by Shore durometer method: hardness on Shore D scale correlates well with rind thickness. Shore D hardness of 20, for example, indicates rind thickness of 0.04 inch (1 millimeter). New hardness test makes it easy to determine rind thickness of sample nondestructively and to adjust fabrication variables accordingly.

Social marketing: application to medical education.

PubMed

David, S P; Greer, D S

2001-01-16

Medical education is often a frustrating endeavor, particularly when it attempts to change practice behavior. Traditional lecture-based educational methods are limited in their ability to sustain concentration and interest and to promote learner adherence to best-practice guidelines. Marketing techniques have been very effective in changing consumer behavior and physician behavior. However, the techniques of social marketing-goal identification, audience segmentation, and market research-have not been harnessed and applied to medical education. Social marketing can be applied to medical education in the effort to go beyond inoculation of learners with information and actually change behaviors. The tremendous potential of social marketing for medical education should be pilot-tested and systematically evaluated.

Virginia Department of Transportation HAR Operational Guidelines

DOT National Transportation Integrated Search

1995-08-01

These guidelines have been developed to help Virginia Department of Transportation (VDOT) personnel effectively operate highway advisory radio (HAR) systems. Operators should continually bear in mind that it is of paramount importance that HAR messag...

Discounting the value of safety: effects of perceived risk and effort.

PubMed

Sigurdsson, Sigurdur O; Taylor, Matthew A; Wirth, Oliver

2013-09-01

Although falls from heights remain the most prevalent cause of fatalities in the construction industry, factors impacting safety-related choices associated with work at heights are not completely understood. Better tools are needed to identify and study the factors influencing safety-related choices and decision making. Using a computer-based task within a behavioral economics paradigm, college students were presented a choice between two hypothetical scenarios that differed in working height and effort associated with retrieving and donning a safety harness. Participants were instructed to choose the scenario in which they were more likely to wear the safety harness. Based on choice patterns, switch points were identified, indicating when the perceived risk in both scenarios was equivalent. Switch points were a systematic function of working height and effort, and the quantified relation between perceived risk and effort was described well by a hyperbolic equation. Choice patterns revealed that the perceived risk of working at heights decreased as the effort to retrieve and don a safety harness increased. Results contribute to the development of computer-based procedure for assessing risk discounting within a behavioral economics framework. Such a procedure can be used as a research tool to study factors that influence safety-related decision making with a goal of informing more effective prevention and intervention strategies. Copyright © 2013 National Safety Council and Elsevier Ltd. All rights reserved.

SURVIVAL EFFICACY OF THE PEGYLATED G-CSFS MAXY-G34 AND NEULASTA IN A MOUSE MODEL OF LETHAL H-ARS, AND RESIDUAL BONE MARROW DAMAGE IN TREATED SURVIVORS

PubMed Central

Chua, Hui Lin; Plett, P. Artur; Sampson, Carol H.; Katz, Barry P.; Carnathan, Gilbert W.; MacVittie, Thomas J.; Lenden, Keith; Orschell, Christie M.

2013-01-01

In an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS), along with the lead MCM for licensure and stockpiling, G-CSF. Both PEG-G-CSFs were shown to retain significant survival efficacy when administered as a single dose 24hr post-exposure, compared to the 16 daily doses of G-CSF required for survival efficacy. Furthermore, 0.1 mg kg−1 of either PEG-G-CSF effected survival of lethally-irradiated mice that was similar to a 10-fold higher dose. The one dose/low dose administration schedules are attractive attributes of radiation MCM given the logistical challenges of medical care in a mass casualty event. Maxy-G34-treated mice that survived H-ARS were examined for residual bone marrow damage (RBMD) up to 9mo post-exposure. Despite differences in Sca-1 expression and cell cycle position in some hematopoietic progenitor phenotypes, Maxy-G34-treated mice exhibited the same degree of hematopoietic stem cell (HSC) insufficiency as vehicle treated H-ARS survivors in competitive transplantation assays of 150 purified Sca-1+cKit+lin-CD150+ cells. These data suggest that Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD, but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy-G34, as well as Neulasta, as MCM against radiation. PMID:24276547

Region IV Transit Workshop: Harnessing the Private Sector

DOT National Transportation Integrated Search

1988-09-01

This Report constitutes the Proceedings of the Region IV Transit Workshop: : Harnessing the Private Sector. Included in this document is a general report of : the activities of the Workshop. : The purpose ot the Region IV Transit Workshop: Harnessing...

Human Activity Recognition by Combining a Small Number of Classifiers.

PubMed

Nazabal, Alfredo; Garcia-Moreno, Pablo; Artes-Rodriguez, Antonio; Ghahramani, Zoubin

2016-09-01

We consider the problem of daily human activity recognition (HAR) using multiple wireless inertial sensors, and specifically, HAR systems with a very low number of sensors, each one providing an estimation of the performed activities. We propose new Bayesian models to combine the output of the sensors. The models are based on a soft outputs combination of individual classifiers to deal with the small number of sensors. We also incorporate the dynamic nature of human activities as a first-order homogeneous Markov chain. We develop both inductive and transductive inference methods for each model to be employed in supervised and semisupervised situations, respectively. Using different real HAR databases, we compare our classifiers combination models against a single classifier that employs all the signals from the sensors. Our models exhibit consistently a reduction of the error rate and an increase of robustness against sensor failures. Our models also outperform other classifiers combination models that do not consider soft outputs and an Markovian structure of the human activities.

KSC-07pd3632

NASA Image and Video Library

2007-12-14

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A, technicians overlook wires and monitoring equipment that will be used to validate the circuit on the test wiring from the electrical harness in space shuttle Atlantis' aft main engine compartment connected with the engine cut-off system. The test wiring leads from the tail mast on the mobile launcher platform to the interior where the Time Domain Reflectometry, or TDR, test equipment will be located to test the sensor system. Photo credit: NASA/Kim Shiflett

Effects of radio transmitters on nesting captive mallards

USGS Publications Warehouse

Houston, Robert A.; Greenwood, Raymond J.

1993-01-01

Radio packages may subtly affect bird behavior and condition, and thus could bias results from studies using this technique. To assess effects on reproduction of mallards (Anas platyrhynchos), we tested 3 types of back-mounted radio packages on captive females. Eight paired females were randomly assigned to each of 4 treatments: 4-g transmitter attached with sutures and glue, 10-g or 18-g transmitter attached with a harness, and no transmitter (control). All mallards were fed ad libitum. No differences were detected among treatments in number of clutches, clutch size, nesting interval, egg mass, or body mass; powers (range = 0.15-0.48) of tests were low. Feather wear and skin irritation around radio packages were minimal. Birds retained sutured transmitters for an average of 43.5 days (range = 3-106 days) and harness transmitters for the duration of the study (106 days). Sutures were not reliable and presently are not recommended as an attachment method. Caution is advised in applying these results to radio-equipped mallards in the wild.

Sea floor topography and backscatter intensity of the Historic Area Remediation Site (HARS), offshore of New York, based on multibeam surveys conducted in 1996, 1998, and 2000

USGS Publications Warehouse

Butman, Bradford; Danforth, W.W.; Knowles, S.C.; May, Brian; Serrett, Laurie

2000-01-01

An area offshore of Sandy Hook, New Jersey, has been used extensively for disposal of dredged and other materials, derived from the New York/New Jersey Harbor and surrounding areas, since the late 1800's (Figure 1). Between 1976 and 1995, the New York Bight Dredged Material Disposal Site, also known as the Mud Dump Site (Figure 2), received on average about 6 million cubic yards of material each year from federal and private maintenance dredging and from harbor deepening activities (Massa and others, 1996). In September 1997 the Mud Dump Site (MDS) was closed as an official ocean disposal site by the U.S. Environmental Protection Agency (http://www.epa.gov/), and the MDS and surrounding areas were designated as the Historic Area Remediation Site (HARS). The HARS is subdivided into a Primary Remediation Area (PRA, subdivided into 9 cells), a Buffer Zone, and a No-Discharge Zone (Figure 2). The sea floor of the HARS, approximately 9 square nautical miles in area, is being remediated by placing at least a one-meter cap of Category I (clean) dredged material on top of the existing surface sediments that exhibit varying degrees of degradation. (See http://www.nan.usace.army.mil/business/prjlinks/dmmp/benefic/hars.htm)(Category I sediments have no potential short or long-term impacts and are acceptable for unrestricted ocean disposal (EPA, 1996)). About 1.1 million cubic yards of dredged material for remediation was placed in the HARS in 1999, and 2.5 million cubic yards in 2000. Three multibeam echosounder surveys were carried out to map the topography and surficial geology of the HARS. The surveys were conducted November 23 - December 3, 1996, October 26 - November 11, 1998, and April 6 - 30, 2000. The surveys were carried out as part of a larger survey of the Hudson Shelf Valley and adjacent shelf (Butman and others, 1998, (http://pubs.usgs.gov/openfile/of98-616/). This report presents maps showing topography, shaded relief, and backscatter intensity (a measure of sea floor texture and roughness) at a scale of 1:25,000. Comparison of the topography and backscatter intensity from the three surveys show changes in topography and surficial sediment properties resulting from placement of dredged material in 1996 and 1997 prior to closure of the Mud Dump Site, as well as placement of capping material for remediation of the HARS. The surficial geology and sediments of the HARS and the surrounding region are described in Butman and others (1998), (http://pubs.usgs.gov/openfile/of98-616/, Schwab and others (1997, 2000, http://pubs.usgs.gov/openfile/of00-295/). A history of waste disposal in the New York Bight region is presented in Massa and others (1996).

MSFC inspections of installed polyimide wire

NASA Technical Reports Server (NTRS)

Landers, Joe C.

1994-01-01

An alert was issued because of the arc-tracking possibilities of installed polyimide wire harnesses. MSFC undertook a program to try to enhance the safety and reliability of these harnesses. Photographs are presented showing the need for inspections of installed wiring harnesses.

Early bioenergetic evolution

PubMed Central

Sousa, Filipa L.; Thiergart, Thorsten; Landan, Giddy; Nelson-Sathi, Shijulal; Pereira, Inês A. C.; Allen, John F.; Lane, Nick; Martin, William F.

2013-01-01

Life is the harnessing of chemical energy in such a way that the energy-harnessing device makes a copy of itself. This paper outlines an energetically feasible path from a particular inorganic setting for the origin of life to the first free-living cells. The sources of energy available to early organic synthesis, early evolving systems and early cells stand in the foreground, as do the possible mechanisms of their conversion into harnessable chemical energy for synthetic reactions. With regard to the possible temporal sequence of events, we focus on: (i) alkaline hydrothermal vents as the far-from-equilibrium setting, (ii) the Wood–Ljungdahl (acetyl-CoA) pathway as the route that could have underpinned carbon assimilation for these processes, (iii) biochemical divergence, within the naturally formed inorganic compartments at a hydrothermal mound, of geochemically confined replicating entities with a complexity below that of free-living prokaryotes, and (iv) acetogenesis and methanogenesis as the ancestral forms of carbon and energy metabolism in the first free-living ancestors of the eubacteria and archaebacteria, respectively. In terms of the main evolutionary transitions in early bioenergetic evolution, we focus on: (i) thioester-dependent substrate-level phosphorylations, (ii) harnessing of naturally existing proton gradients at the vent–ocean interface via the ATP synthase, (iii) harnessing of Na+ gradients generated by H+/Na+ antiporters, (iv) flavin-based bifurcation-dependent gradient generation, and finally (v) quinone-based (and Q-cycle-dependent) proton gradient generation. Of those five transitions, the first four are posited to have taken place at the vent. Ultimately, all of these bioenergetic processes depend, even today, upon CO2 reduction with low-potential ferredoxin (Fd), generated either chemosynthetically or photosynthetically, suggesting a reaction of the type ‘reduced iron → reduced carbon’ at the beginning of bioenergetic evolution. PMID:23754820

Constraint methods that accelerate free-energy simulations of biomolecules.

PubMed

Perez, Alberto; MacCallum, Justin L; Coutsias, Evangelos A; Dill, Ken A

2015-12-28

Atomistic molecular dynamics simulations of biomolecules are critical for generating narratives about biological mechanisms. The power of atomistic simulations is that these are physics-based methods that satisfy Boltzmann's law, so they can be used to compute populations, dynamics, and mechanisms. But physical simulations are computationally intensive and do not scale well to the sizes of many important biomolecules. One way to speed up physical simulations is by coarse-graining the potential function. Another way is to harness structural knowledge, often by imposing spring-like restraints. But harnessing external knowledge in physical simulations is problematic because knowledge, data, or hunches have errors, noise, and combinatoric uncertainties. Here, we review recent principled methods for imposing restraints to speed up physics-based molecular simulations that promise to scale to larger biomolecules and motions.

Albumin-based drug delivery: harnessing nature to cure disease.

PubMed

Larsen, Maja Thim; Kuhlmann, Matthias; Hvam, Michael Lykke; Howard, Kenneth A

2016-01-01

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform.

Impact of Harness Attachment Point on Kinetics and Kinematics During Sled Towing.

PubMed

Bentley, Ian; Atkins, Steve J; Edmundson, Christopher J; Metcalfe, John; Sinclair, Jonathan K

2016-03-01

Resisted sprint training is performed in a horizontal direction and involves similar muscles, velocities, and ranges of motion (ROM) to those of normal sprinting. Generally, sleds are attached to the athletes through a lead (3 m) and harness; the most common attachment points are the shoulder or waist. At present, it is not known how the different harness point's impact on the kinematics and kinetics associated with sled towing (ST). The aim of the current investigation was to examine the kinetics and kinematics of shoulder and waist harness attachment points in relation to the acceleration phase of ST. Fourteen trained men completed normal and ST trials, loaded at 10% reduction of sprint velocity. Sagittal plane kinematics from the trunk, hip, knee, and ankle were measured, together with stance phase kinetics (third footstrike). Kinetic and kinematic parameters were compared between harness attachments using one-way repeated-measures analysis of variance. The results indicated that various kinetic differences were present between the normal and ST conditions. Significantly greater net horizontal mean force, net horizontal impulses, propulsive mean force, and propulsive impulses were measured (p < 0.05). Interestingly, the waist harness also led to greater net horizontal impulse when compared with the shoulder attachment (p < 0.001). In kinematic terms, ST conditions significantly increased peak flexion in hip, knee, and ankle joints compared with the normal trials (p < 0.05). Results highlighted that the shoulder harness had a greater impact on trunk and knee joint kinematics when compared with the waist harness (p < 0.05). In summary, waist harnesses seem to be the most suitable attachment point for the acceleration phase of sprinting. Sled towing with these attachments resulted in fewer kinematic alterations and greater net horizontal impulse when compared with the shoulder harness. Future research is necessary in order to explore the long-term adaptations of these acute changes.

The Impact of Harness Impedance on Hall Thruster Discharge Oscillations

NASA Technical Reports Server (NTRS)

Pinero, Luis R.

2017-01-01

Hall thrusters exhibit characteristic discharge voltage and current oscillations during steady-state operation. The lower frequency breathing-mode current oscillations are inherent to each thruster and could impact thruster operation and power processing unit (PPU) design. The design of the discharge output filter, in particular, the output capacitor is important because it supplies the high peak current oscillations that the thruster demands. However, space-rated, high-voltage capacitors are not readily available and can have significant mass and volume. So, it is important for a PPU designer to know what is the minimum amount of capacitance required to operate a thruster. Through Simulation Program with Integrated Circuit Emphasis modeling and electrical measurements on the Hall Effect Rocket with Magnetic Shielding thruster, it was shown that the harness impedance between the power supply and the thruster is the main contributor towards generating voltage ripple at the thruster. Also, increasing the size of the discharge filter capacitor, as previously implemented during thruster tests, does not reduce the voltage oscillations. The electrical characteristics of the electrical harness between the discharge supply and the thruster is crucial to system performance and could have a negative impact on performance, life and operation.

The Impact of Harness Impedance on Hall Thruster Discharge Oscillations

NASA Technical Reports Server (NTRS)

Pinero, Luis R.

2017-01-01

Hall thrusters exhibit characteristic discharge voltage and current oscillations during steady-state operation. The lower frequency breathing-mode current oscillations are inherent to each thruster and could impact thruster operation and PPU design. The design of the discharge output filter, in particular, the output capacitor is important because it supplies the high peak current oscillations that the thruster demands. However, space-rated, high-voltage capacitors are not readily available and can have significant mass and volume. So, it is important for a PPU designer to know what is the minimum amount of capacitance required to operate a thruster. Through SPICE modeling and electrical measurements on the Hall Effect Rocket with Magnetic Shielding (HERMeS) thruster, it was shown that the harness impedance between the power supply and the thruster is the main contributor towards generating voltage ripple at the thruster. Also, increasing the size of the discharge filter capacitor, as previously implemented during thruster tests, does not reduce the voltage oscillations. The electrical characteristics of the electrical harness between the discharge supply and the thruster is crucial to system performance and could have a negative impact on performance, life and operation.

The benefits of the use of shoulder harness in general aviation aircraft.

DOT National Transportation Integrated Search

1972-02-01

The installation and use of shoulder harnesses is a practical and relatively inexpensive solution to the problem of maintaining separation between man and machine during an aircraft crash sequence. The addition of shoulder harness to the tiedown chai...

42 CFR 84.196 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Chemical Cartridge Respirators § 84.196 Harnesses; installation and construction; minimum...

Spring control of wire harness loops

NASA Technical Reports Server (NTRS)

Curcio, P. J.

1979-01-01

Negator spring control guides wire harness between movable and fixed structure. It prevents electrical wire harness loop from jamming or being severed as wire moves in response to changes in position of aircraft rudder. Spring-loaded coiled cable controls wire loop regardless of rudder movement.

SSME Electrical Harness and Cable Development and Evolution

NASA Technical Reports Server (NTRS)

Abrams, Russ; Heflin, Johnny; Burns, Bob; Camper, Scott J.; Hill, Arthur J.

2010-01-01

The Space Shuttle Main Engine (SSME) electrical harness and cable system consists of the various interconnecting devices necessary for operation of complex rocket engine functions. Thirty seven harnesses incorporate unique connectors, backshell adapters, conductors, insulation, shielding, and physical barriers for a long maintenance-free life while providing the means to satisfy performance requirements and to mitigate adverse environmental influences. The objective of this paper is to provide a description of the SSME electrical harness and cable designs as well as the development history and lessons learned.

Damping Models for Shear-Deformable Beam with Applications to Spacecraft Wiring Harness

DTIC Science & Technology

2014-10-28

AFRL-RV-PS- TR-2014-0189 AFRL-RV-PS- TR-2014-0189 DAMPING MODELS FOR SHEAR-DEFORMABLE BEAM WITH APPLICATIONS TO SPACECRAFT WIRING HARNESS ...Feb 2012 4. TITLE AND SUBTITLE Damping Models for Shear-Deformable Beam with Applications to Spacecraft Wiring Harness 5a. CONTRACT NUMBER FA9453-12...behavior of wiring harnesses . The emphasis in this project will be on the extension of the shear-beam damping model to the Timoshenko beam, a beam model

Fiber optic sensing subsystem for temperature monitoring in space in-flight applications

NASA Astrophysics Data System (ADS)

Abad, S.; Araujo, F.; Pinto, F.; González Torres, J.; Rodriguez, R.; Moreno, M. A.

2017-11-01

Fiber Optic Sensor (FOS) technology presents long recognized advantages which enable to mitigate deficient performance of conventional technology in hazard-environments common in spacecraft monitoring applications, such as: multiplexing capability, immunity to EMI/RFI, remote monitoring, small size and weight, electrical insulation, intrinsically safe operation, high sensibility and long term reliability. A key advantage is also the potential reduction of Assembly Integration and Testing (AIT) time achieved by the multiplexing capability and associated reduced harness. In the frame of the ESA's ARTES5.2 and FLPP-Phase 3 programs, Airbus DS-Crisa and FiberSensing are developing a Fiber Bragg Grating (FBG) - based temperature monitoring system for application in space telecommunication platforms and launchers. The development encompasses both the interrogation unit and the FBG temperature sensors and associated fiber harness. In parallel Airbus DS - Crisa is developing a modular RTU (RTU2015) to provide maximum flexibility and mission-customization capability for RTUs maintaining the ESA's standards at I/O interface level [1]. In this context, the FBG interrogation unit is designed as a module to be compatible, in both physical dimensions and electrical interfaces aspects, with the Electrical Internal Interface Bus of the RTU2015, thus providing the capability for a hybrid electrical and optical monitoring system.

The Trojan Female Technique for pest control: a candidate mitochondrial mutation confers low male fertility across diverse nuclear backgrounds in Drosophila melanogaster.

PubMed

Dowling, Damian K; Tompkins, Daniel M; Gemmell, Neil J

2015-10-01

Pest species represent a major ongoing threat to global biodiversity. Effective management approaches are required that regulate pest numbers, while minimizing collateral damage to nontarget species. The Trojan Female Technique (TFT) was recently proposed as a prospective approach to biological pest control. The TFT draws on the evolutionary hypothesis that maternally inherited mitochondrial genomes are prone to the accumulation of male, but not female, harming mutations. These mutations could be harnessed to provide trans-generational fertility-based control of pest species. A candidate TFT mutation was recently described in the fruit fly, Drosophila melanogaster, which confers male-only sterility in the specific isogenic nuclear background in which it is maintained. However, applicability of the TFT relies on mitochondrial mutations whose male-sterilizing effects are general across nuclear genomic contexts. We test this assumption, expressing the candidate TFT-mutation bearing haplotype alongside a range of nuclear backgrounds and comparing its fertility in males, relative to that of control haplotypes. We document consistently lower fertility for males harbouring the TFT mutation, in both competitive and noncompetitive mating contexts, across all nuclear backgrounds screened. This indicates that TFT mutations conferring reduced male fertility can segregate within populations and could be harnessed to facilitate this novel form of pest control.

The Trojan Female Technique for pest control: a candidate mitochondrial mutation confers low male fertility across diverse nuclear backgrounds in Drosophila melanogaster

PubMed Central

Dowling, Damian K; Tompkins, Daniel M; Gemmell, Neil J

2015-01-01

Pest species represent a major ongoing threat to global biodiversity. Effective management approaches are required that regulate pest numbers, while minimizing collateral damage to nontarget species. The Trojan Female Technique (TFT) was recently proposed as a prospective approach to biological pest control. The TFT draws on the evolutionary hypothesis that maternally inherited mitochondrial genomes are prone to the accumulation of male, but not female, harming mutations. These mutations could be harnessed to provide trans-generational fertility-based control of pest species. A candidate TFT mutation was recently described in the fruit fly, Drosophila melanogaster, which confers male-only sterility in the specific isogenic nuclear background in which it is maintained. However, applicability of the TFT relies on mitochondrial mutations whose male-sterilizing effects are general across nuclear genomic contexts. We test this assumption, expressing the candidate TFT-mutation bearing haplotype alongside a range of nuclear backgrounds and comparing its fertility in males, relative to that of control haplotypes. We document consistently lower fertility for males harbouring the TFT mutation, in both competitive and noncompetitive mating contexts, across all nuclear backgrounds screened. This indicates that TFT mutations conferring reduced male fertility can segregate within populations and could be harnessed to facilitate this novel form of pest control. PMID:26495040

KSC-08pd0002

NASA Image and Video Library

2008-01-04

KENNEDY SPACE CENTER, FLA. -- At a lab at NASA's Kennedy Space Center, Kevin Wyckoff, an aerospace technician with the United Launch Alliance, examines an electrical wiring harness. The harness will be inserted into a replacement feed-through connector during preparations to solder the pins to the socket of the connector. The connector will later be installed in the external fuel tank for space shuttle Atlantis' STS-122 mission. The technician performed this exacting task on the Centaur upper stage for Atlas and Titan launches in 1994 and was specifically chosen for the task. Soldering the connector pins and sockets together addresses the most likely cause of a problem in the engine cutoff sensor system, or ECO system. Some of the tank's ECO sensors failed during propellant tanking for launch attempts on Dec. 6 and Dec. 9. Results of a tanking test on Dec. 18 pointed to an open circuit in the feed-through connector wiring, which is located at the base of the tank. The feed-through connector passes the wires from the inside of the tank to the outside. After the soldering is completed and the connector is reinstalled, shuttle program managers will decide on how to proceed. The launch date for mission STS-122 is under review. Photo credit: NASA/Kim Shiflett

Heritability and factors associated with number of harness race starts in the Spanish Trotter horse population.

PubMed

Solé, M; Valera, M; Gómez, M D; Sölkner, J; Molina, A; Mészáros, G

2017-05-01

Longevity/durability is a relevant trait in racehorses. Genetic analysis and knowledge of factors that influence number of harness race starts would be advantageous for both horse welfare and the equine industry. To perform a genetic analysis on harness racing using number of races as a measure of longevity/durability and to identify factors associated with career length in Spanish Trotter Horses (STH). Longitudinal study. Performance data (n = 331,970) on the STH population for harness racing at national level between 1990 and 2014 were used. A grouped data model was fitted to assess factors influencing the risk of ending harness racing career and to estimate the heritability and breeding values for total number of harness races starts as an indicator of horses' longevity and durability. The model included sex, age at first race and first start earnings as time-independent effects, and the calendar year, driver, trainer, racetrack category and season of competition as time-dependent effects. Across the whole dataset, the average number of harness races horses achieved in Spain was 54.7 races, and this was associated with the horses' sex, age at first race and first start earnings, calendar year, driver, racetrack category, and season. The heritability estimated (0.17 ± 0.01) for number of harness race starts indicates that a beneficial response to direct genetic selection can be expected. Data on horses' health status were not available. Horses' total number of harness race starts is a promising tool for genetic analysis and the evaluation of racing longevity and durability. The estimated heritability provides evidence to support the application of genetic selection of total career number of races to improve longevity/durability of STH. © 2016 EVJ Ltd.

Sonar Transducer Reliability Improvement Program (STRIP) FY80.

DTIC Science & Technology

1980-07-01

heating element powered by a temperature conLroller (YSI model 74) with a series 400 thermistor probe. Figure 3.1 shows the data and average curves...ATTACHMENT METHODS General Welded Receptacles Threaded or Bolted Receptacles Elastomeric Bonded Receptacles I I!11 " SECTION 12 - CABLE HARNESS TEST

The Cheshire Jet: Harnessing Metamaterials to Achieve an Optical Stealth Capability

DTIC Science & Technology

2010-07-01

Prometheus Books, 2005. Hamilton, Dave. Address. 23rd Annual National Test and Evaluation Conference, Hilton Head Island, SC, 15 March 2007. http...ment 2008: Challenges and Implications for the Future Joint Force. Norfolk, VA: Center for Joint Futures, 25 November 2008. Valentine, Jason , Shuang

Electric Propulsion Pointing Mechanism for BepiColombo

NASA Astrophysics Data System (ADS)

Janu, Paul; Neugebauer, Christian; Schermann, Rudolf; Supper, Ludwig

2013-09-01

Since 17 years the development of Electric Propulsion Pointing Mechanisms for commercial and scientific satellite applications is a key-product activity for RUAG Space in Vienna.As one of the most innovative EP mechanisms presently under development in Vienna this paper presents the Electric Propulsion Mechanism for the ESA Bepi Colombo Mission.RUAG Space delivers the mechanism assembly, consisting of the mechanisms and the control electronics.The design-driving requirements are:- the pointing capability around the stowed configuration under resitive torque coming from the thruster supply harness, the thruster supply piping, and the mechanism harness. The pointing capability around the stowed configuration is realized via a central release nut together with a spring loaded knuckle-lever system which in essence forms a "frangible pipe" that is stiff during launch and collapses upon release. The resistive torques are minimized by a helical arrangement of the supply pipes and of the mechanism harness, and a guided low stiffness routing of the thruster supply harness. A high detent torque actuator is used to maintain pointing direction in un-powered condition. Also the direct measurement of the torque on the actuator shaft during random vibration is presented in the paper.- the specified maximum input loads to the thruster. The mechanism has not only to point the thruster, but also to protect it against high launch loads. A very low Eigen- frequency of the mechanism/thruster sub-assembly of around 65 Hz was selected to minimize coupling with the thruster's modes and so to minimize load input to the thruster. An elastomer damping system is implemented which minimizes amplification in this frequency area so that the sine input can be sustained by the mechanism and the thruster. The measured amplification of 3.1 turned out to successfully protect the thruster from the launch vibrations.- the thermal load on the mechanism from the dissipation of the thruster and from the solar radiation.A staged temperature zone concept was selected, separating different temperature zones, and keeping the thermally sensitive elements in their operating temperature ranges.This paper outlines the design solution for these design driving requirements, presents the test results, and compares the results of the predictions with the tested values of the qualification tests. It also points out the lessons learnt during this development process.

Developmental dysplasia of the hip in the newborn: A systematic review

PubMed Central

Gulati, Vivek; Eseonu, Kelechi; Sayani, Junaid; Ismail, Nizar; Uzoigwe, Chika; Choudhury, Muhammed Zaki; Gulati, Pooja; Aqil, Adeel; Tibrewal, Saket

2013-01-01

Developmental dysplasia of the hip (DDH) denotes a wide spectrum of conditions ranging from subtle acetabular dysplasia to irreducible hip dislocations. Clinical diagnostic tests complement ultrasound imaging in allowing diagnosis, classification and monitoring of this condition. Classification systems relate to the alpha and beta angles in addition to the dynamic coverage index (DCI). Screening programmes for DDH show considerable geographic variation; certain risk factors have been identified which necessitate ultrasound assessment of the newborn. The treatment of DDH has undergone significant evolution, but the current gold standard is still the Pavlik harness. Duration of Pavlik harness treatment has been reported to range from 3 to 9.3 mo. The beta angle, DCI and the superior/lateral femoral head displacement can be assessed via ultrasound to estimate the likelihood of success. Success rates of between 7% and 99% have been reported when using the harness to treat DDH. Avascular necrosis remains the most devastating complication of harness usage with a reported rate of between 0% and 28%. Alternative non-surgical treatment methods used for DDH include devices proposed by LeDamany, Frejka, Lorenz and Ortolani. The Rosen splint and Wagner stocking have also been used for DDH treatment. Surgical treatment for DDH comprises open reduction alongside a combination of femoral or pelvic osteotomies. Femoral osteotomies are carried out in cases of excessive anteversion or valgus deformity of the femoral neck. The two principal pelvic osteotomies most commonly performed are the Salter osteotomy and Pemberton acetabuloplasty. Serious surgical complications include epiphyseal damage, sciatic nerve damage and femoral neck fracture. PMID:23610749

Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials.

PubMed

DeVincenzo, John P

2009-10-01

A revolution in the understanding of RNA biological processing and control is leading to revolutionary new concepts in human therapeutics. It has become increasingly clear that the so called "non-coding RNA" exerts specific and profound functional control on regulation of protein production and indeed controls the expression of all genes. Harnessing this naturally-occurring RNA-mediated regulation of protein production has immense human therapeutic potential. These processes are collectively known as RNA interference (RNAi). RNAi is a recently discovered, naturally-occurring intracellular process that regulates gene expression through the silencing of specific mRNAs. Methods of harnessing this natural pathway are being developed that allow the catalytic degradation of targeted mRNAs using specifically designed complementary small inhibitory RNAs (siRNA). siRNAs are being chemically modified to acquire drug-like properties. Numerous recent high profile publications have provided proofs of concept that RNA interference may be useful therapeutically. Much of the design of these siRNAs can be accomplished bioinformatically, thus potentially expediting drug discovery and opening new avenues of therapy for many uncommon, orphan, or emerging diseases. This makes this approach very attractive for developing therapies targeting orphan diseases including neonatal diseases. Theoretically, any disease that can be ameliorated through knockdown of any endogenous or exogenous protein is a potential therapeutic target for RNAi-based therapeutics. Lung diseases are particularly attractive targets for RNAi therapeutics since the affected cells' location increases their accessibility to topical administration of siRNA, for example by aerosol. Respiratory viral infections and chronic lung disease are examples of such diseases. RNAi therapeutics have been shown to be active against RSV, parainfluenza and human metapneumoviruses in vitro and in vivo resulting in profound antiviral effects. The first proof of concept test of efficacy of an RNAi-based therapeutic in man has been initiated. A discussion of the science behind RNA interference is followed by a presentation of the potential practical issues in applying this technology to neonatal respiratory viral diseases. RNAi may offer new strategies for the treatment of a variety of orphan diseases including neonatal diseases, RSV infections, and other respiratory viruses.

The angle of shoulder slope in normal males as a factor in shoulder-harness design.

DOT National Transportation Integrated Search

1965-03-01

In order to establish criteria for more comfortable shoulder-harness design, this study was conducted to determine the angle of slope of the top of the shoulders where poorly fitting shoulder harness may produce discomfort and, occasionally, function...

42 CFR 84.133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air Respirators § 84.133 Harnesses; installation and construction; minimum requirements...

Introduction of hand-assisted retroperitoneoscopic living donor nephrectomy at Karolinska University Hospital Huddinge.

PubMed

Gjertsen, H; Sandberg, A-K A; Wadström, J; Tydén, G; Ericzon, B-G

2006-10-01

Living donor kidney transplantation accounts for about 50% of the total number of renal transplantations at our center. From 1999 through 2005, 75 out of 220 living donor nephrectomies were performed with a laparoscopic technique (LLDN). In June 2005, we introduced the technique of hand-assisted retroperitoneoscopic nephrectomy (HARS) for living donors. Since the introduction until the end of 2005, 11 out of 18 living donor nephrectomies (LDN) were performed with HARS. Reduced operation time was observed for the HARS group (mean, 166 minutes) compared with the LLDN (mean, 244 minutes). Two grafts showed delayed function, one in the LLND group and one in the HARS group. No major perioperative or postoperative complications were observed in the HARS group, whereas one patient who underwent LLDN developed severe pancreatitis. So far in our hands HARS is a fast and safe procedure with results comparable with open LDN. Compared to LLDN, we experienced reduced operation time together with the advantage of retroperitoneal access.

An examination of shoulder kinematics and kinetics when using a commercial trunk harness while sheep shearing.

PubMed

Gregory, Diane E; Milosavljevic, Stephan; Pal, Poonam; Callaghan, Jack P

2008-01-01

Sheep shearing is a very physically demanding occupation, especially on the low back, such that many commercial harnesses have been developed to help reduce the load on the back. Such harnesses have been shown to significantly reduce peak and cumulative low back loads; however, the effect that these harnesses have on the shoulders, which are also highly involved during sheep shearing, has not been previously examined. The purpose of this study was to examine the shoulder postures and cumulative shoulder moments of 12 New Zealand sheep shearers. The use of the trunk harness reduced the percentage of time spent in shoulder flexion greater than 90 degrees and the time spent in shoulder abduction greater than 45 degrees as well as reduced the cumulative net joint flexor, abductor, and adductor shoulder moments by a minimum of 21%, 14%, and 42%, respectively. Therefore, the use of a commercial trunk harness to reduce low back injury may also help to reduce the risk of shoulder injury while sheep shearing.

Loss of Consciousness During Single Sling Helicopter Hoist Rescue Resulting in a Fatal Fall.

PubMed

Biles, Jessie; Garner, Alan A

2016-09-01

Although harness suspension trauma has been documented since the 1960s, especially in the mountaineering setting, there is little robust medical research into the area. Helicopter hoist rescue shares similar risks and is reserved for those cases that cannot be accessed safely by other routes, where extrication may be hazardous or will take an unreasonable amount of time. The single sling or chest harness used for hoist rescue is a single harness around the upper torso and is easier and quicker to apply than a stretcher. However, the risks of a chest harness need to be balanced against the patient's condition, the environment, aircraft performance, and the urgency of the rescue. We report an adult male falling 80 ft to his death while being hoisted into a rescue helicopter for a likely fractured ankle. A single rescue sling harness technique was used, but the patient became unconscious, slipped out of the harness, and fell. He had significant comorbidities, including cardiomyopathy, obstructive sleep apnea, morbid obesity, and diabetes. A decrease in cardiac output secondary to thoracic compression was the presumed cause for his loss of consciousness and the potential physiological mechanisms and modifying factors are discussed. Further research into harness suspension trauma is required. Stretcher, double point harnesses, or rescue baskets are likely safer methods of hoisting, especially in a medically compromised patient. Biles J, Garner AA. Loss of consciousness during single sling helicopter hoist rescue resulting in a fatal fall. Aerosp Med Hum Perform. 2016; 87(9):821-824.

Lumbar spine disc heights and curvature: upright posture vs. supine compression harness

NASA Technical Reports Server (NTRS)

Lee, Shi-Uk; Hargens, Alan R.; Fredericson, Michael; Lang, Philipp K.

2003-01-01

INTRODUCTION: Spinal lengthening in microgravity is thought to cause back pain in astronauts. A spinal compression harness can compress the spine to eliminate lengthening but the loading condition with harness is different than physiologic conditions. Our purpose was to compare the effect of spine compression with a harness in supine position on disk height and spinal curvature in the lumbar spine to that of upright position as measured using a vertically open magnetic resonance imaging system. METHODS: Fifteen healthy subjects volunteered. On day 1, each subject lay supine for an hour and a baseline scan of the lumbar spine was performed. After applying a load of fifty percent of body weight with the harness for thirty minutes, the lumbar spine was scanned again. On day 2, after a baseline scan, a follow up scan was performed after kneeling for thirty minutes within the gap between two vertically oriented magnetic coils. Anterior and posterior disk heights, posterior disk bulging, and spinal curvature were measured from the baseline and follow up scans. RESULTS: Anterior disk heights increased and posterior disk heights decreased compared with baseline scans both after spinal compression with harness and upright posture. The spinal curvature increased by both loading conditions of the spine. DISCUSSION: The spinal compression with specially designed harness has the same effect as the physiologic loading of the spine in the kneeling upright position. The harness shows some promise as a tool to increase the diagnostic capabilities of a conventional MR system.

Does the OVX matter for volatility forecasting? Evidence from the crude oil market

NASA Astrophysics Data System (ADS)

Lv, Wendai

2018-02-01

In this paper, I investigate that whether the OVX and its truncated parts with a certain threshold can significantly help in forecasting the oil futures price volatility basing on the Heterogeneous Autoregressive model of Realized Volatility (HAR-RV). In-sample estimation results show that the OVX has a significantly positive impact on futures volatility. The impact of large OVX on future volatility has slightly powerful compared to the small ones. Moreover, the HARQ-RV model outperforms the HAR-RV in predicting the oil futures volatility. More importantly, the decomposed OVX have more powerful in forecasting the oil futures price volatility compared to the OVX itself.

Solar Technologies

ERIC Educational Resources Information Center

von Hippel, Frank; Williams, Robert H.

1975-01-01

As fossil fuels decrease in availability and environmental concerns increase, soalr energy is becoming a potential major energy source. Already solar energy is used for space heating in homes. Proposals for solar-electric generating systems include land-based or ocean-based collectors and harnessing wind and wave power. Photosynthesis can also…

A Review on Human Activity Recognition Using Vision-Based Method.

PubMed

Zhang, Shugang; Wei, Zhiqiang; Nie, Jie; Huang, Lei; Wang, Shuang; Li, Zhen

2017-01-01

Human activity recognition (HAR) aims to recognize activities from a series of observations on the actions of subjects and the environmental conditions. The vision-based HAR research is the basis of many applications including video surveillance, health care, and human-computer interaction (HCI). This review highlights the advances of state-of-the-art activity recognition approaches, especially for the activity representation and classification methods. For the representation methods, we sort out a chronological research trajectory from global representations to local representations, and recent depth-based representations. For the classification methods, we conform to the categorization of template-based methods, discriminative models, and generative models and review several prevalent methods. Next, representative and available datasets are introduced. Aiming to provide an overview of those methods and a convenient way of comparing them, we classify existing literatures with a detailed taxonomy including representation and classification methods, as well as the datasets they used. Finally, we investigate the directions for future research.

A Review on Human Activity Recognition Using Vision-Based Method

PubMed Central

Nie, Jie

2017-01-01

Human activity recognition (HAR) aims to recognize activities from a series of observations on the actions of subjects and the environmental conditions. The vision-based HAR research is the basis of many applications including video surveillance, health care, and human-computer interaction (HCI). This review highlights the advances of state-of-the-art activity recognition approaches, especially for the activity representation and classification methods. For the representation methods, we sort out a chronological research trajectory from global representations to local representations, and recent depth-based representations. For the classification methods, we conform to the categorization of template-based methods, discriminative models, and generative models and review several prevalent methods. Next, representative and available datasets are introduced. Aiming to provide an overview of those methods and a convenient way of comparing them, we classify existing literatures with a detailed taxonomy including representation and classification methods, as well as the datasets they used. Finally, we investigate the directions for future research. PMID:29065585

MicroRNA Expression for Early Prediction of Late Occurring Hematologic Acute Radiation Syndrome in Baboons.

PubMed

Port, Matthias; Herodin, Francis; Valente, Marco; Drouet, Michel; Ullmann, Reinhard; Doucha-Senf, Sven; Lamkowski, Andreas; Majewski, Matthäus; Abend, Michael

2016-01-01

For effective medical management of radiation-exposed persons after a radiological/nuclear event, blood-based screening measures in the first few days that could predict hematologic acute radiation syndrome (HARS) are needed. For HARS severity prediction, we used microRNA (miRNA) expression changes measured on days one and two after irradiation in a baboon model. Eighteen baboons underwent different patterns of partial or total body irradiation, corresponding to an equivalent dose of 2.5 or 5 Gy. According to changes in blood cell counts (BCC) the surviving baboons (n = 17) exhibited mild (H1-2, n = 4) or more severe (H2-3, n = 13) HARS. In a two Stage study design we screened 667 miRNAs using a quantitative real-time polymerase chain reaction (qRT-PCR) platform. In Stage II we validated candidates where miRNAs had to show a similar regulation (up- or down-regulated) and a significant 2-fold miRNA expression difference over H0. Seventy-two candidate miRNAs (42 for H1-2 and 30 for H2-3) were forwarded for validation. Forty-two of the H1-2 miRNA candidates from the screening phase entered the validation step and 20 of them showed a statistically significant 2-4 fold up-regulation relative to the unexposed reference (H0). Fifteen of the 30 H2-3 miRNAs were validated in Stage II. All miRNAs appeared 2-3 fold down-regulated over H0 and allowed an almost complete separation of HARS categories; the strongest candidate, miR-342-3p, showed a sustained and 10-fold down-regulation on both days 1 and 2. In summary, our data support the medical decision making of the HARS even within the first two days after exposure where diagnostic tools for early medical decision are required but so far missing. The miRNA species identified and in particular miR-342-3p add to the previously identified mRNAs and complete the portfolio of identified mRNA and miRNA transcripts for HARS prediction and medical management.

DEVELOPMENT OF TWO ANDROGEN RECEPTOR ASSAYS USING ADENOVIRAL TRANSDUCTION OF MMTV-LUC REPORTER AND/OR HAR FOR ENDOCRINE SCREENING

EPA Science Inventory

Abstract
The discovery of xenobiotics which interfere with androgen activity has highlighted the need to assess chemicals for their ability to modulate dihydrotestosterone (DHT)-receptor binding. Previous test systems have used cells transfected with plasmid containing a rep...

Harnessing Technology for School Accountability: A Case Study of Implementing a Management Information System

ERIC Educational Resources Information Center

Enomoto, Ernestine K.; Conley, Sharon

2007-01-01

Schools employ educational technology to comply with pressures for greater accountability and efficiency in conducting operations. Specifically, schools use "management information systems" designed to automate data collection of student attendance, grades, test scores, and so on. These management information systems (MIS) employed…

Combining machine learning and ontological data handling for multi-source classification of nature conservation areas

NASA Astrophysics Data System (ADS)

Moran, Niklas; Nieland, Simon; Tintrup gen. Suntrup, Gregor; Kleinschmit, Birgit

2017-02-01

Manual field surveys for nature conservation management are expensive and time-consuming and could be supplemented and streamlined by using Remote Sensing (RS). RS is critical to meet requirements of existing laws such as the EU Habitats Directive (HabDir) and more importantly to meet future challenges. The full potential of RS has yet to be harnessed as different nomenclatures and procedures hinder interoperability, comparison and provenance. Therefore, automated tools are needed to use RS data to produce comparable, empirical data outputs that lend themselves to data discovery and provenance. These issues are addressed by a novel, semi-automatic ontology-based classification method that uses machine learning algorithms and Web Ontology Language (OWL) ontologies that yields traceable, interoperable and observation-based classification outputs. The method was tested on European Union Nature Information System (EUNIS) grasslands in Rheinland-Palatinate, Germany. The developed methodology is a first step in developing observation-based ontologies in the field of nature conservation. The tests show promising results for the determination of the grassland indicators wetness and alkalinity with an overall accuracy of 85% for alkalinity and 76% for wetness.

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 27.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... occupant properly uses the seats, safety belts, and shoulder harnesses provided in the design; and (2) The... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact, although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 29.562 - Emergency landing dynamic conditions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the seats, safety belts, and shoulder harnesses provided in the design; and (2) The occupant is... would cause the greatest load on the shoulder harness), the rotorcraft's lateral axis is contained in a... intact although the structure may have exceeded its limit load. (3) The ATD's shoulder harness strap or...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

14 CFR 23.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... airplane for entry into the United States must provide a safety belt and shoulder harness for each forward- or aft-facing seat which will protect the occupant from serious head injury when subjected to the... safety belt and shoulder harness installed. (b) Each shoulder harness installed at a flight crewmember...

75 FR 51701 - Airworthiness Directives; Learjet Inc. Model 45 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... configuration of the engine and alternator wire harnesses, and the starter/generator wire bundles. For certain... necessary. For certain airplanes, inspecting for clearance between the wire harnesses and the hydraulic and... wire harnesses and the starter/generator wire bundles. (2) Do a detailed inspection for chafing damage...

Symmetry-adapted perturbation theory interaction energy decomposition for some noble gas complexes

NASA Astrophysics Data System (ADS)

Cukras, Janusz; Sadlej, Joanna

2008-06-01

This Letter contains a study of the interaction energy in HArF⋯N 2 and HArF⋯P 2 complexes. Symmetry-adapted perturbation theory (SAPT) has been applied to analyze the electrostatic, induction, dispersion and exchange contributions to the total interaction energy. The interaction energy has also been obtained by supermolecular method at the MP2, MP4, CCSD, CCSD(T) levels. The interaction energy for the studied complexes results from a partial cancelation of large attractive electrostatic, induction, dispersion terms by a strong repulsive exchange contribution. The induction and dispersion effects proved to be crucial in establishing the preference for the colinear HArF⋯N 2 and HArF⋯P 2 structures and shift direction of νHAr stretching vibrations.

State-of-the-Art Model Driven Game Development: A Survey of Technological Solutions for Game-Based Learning

ERIC Educational Resources Information Center

Tang, Stephen; Hanneghan, Martin

2011-01-01

Game-based learning harnesses the advantages of computer games technology to create a fun, motivating and interactive virtual learning environment that promotes problem-based experiential learning. Such an approach is advocated by many commentators to provide an enhanced learning experience than those based on traditional didactic methods.…

Pioneer Venus 12.5 km Anomaly Workshop Report, volume 1

NASA Technical Reports Server (NTRS)

Seiff, A.; Sromovsky, L.; Borucki, W.; Craig, R.; Juergens, D.; Young, R. E.; Ragent, B.

1995-01-01

A workshop was convened at Ames Research Center on September 28 and 29, 1993, to address the unexplained electrical anomalies experienced in December 1978 by the four Pioneer Venus probes below a Venus altitude of 12.5 km. These anomalies caused the loss of valuable data in the deep atmosphere, and, if their cause were to remain unexplained, could reoccur on future Venus missions. The workshop participants reviewed the evidence and studied all identified mechanisms that could consistently account for all observed anomalies. Both hardware problems and atmospheric interactions were considered. Based on a workshop recommendation, subsequent testing identified the cause as being an insulation failure of the external harness. All anomalous events are now explained.

Fiber optic controls for aircraft engines - Issues and implications

NASA Technical Reports Server (NTRS)

Dasgupta, Samhita; Poppel, Gary L.; Anderson, William P.

1991-01-01

Some of the issues involved with the application of fiber-optic controls for aircraft engines in the harsh operating environment are addressed, with emphasis on fiber-optic temperature, pressure, position, and speed sensors. Criteria are established to evaluate the optical modulation technique, the sensor/control unit interconnection, and the electrooptic architecture. Single mode and polarization dependent sensor types, sensors which depend on the reflection and/or transmission of light through the engine environment, and intensity-based analog sensors are eliminated as a possible candidate for engine implementation. Fiber-optic harnesses tested for their optical integrity, temperature stability, and mechanical strength, exhibit a capacity to meet mechanical strength requirements and still gain a significant reduction in cable weight.

Pumped Fluid Loop Heat Rejection and Recovery Systems for Thermal Control of the Mars Science Laboratory

NASA Technical Reports Server (NTRS)

Bhandari, Pradeep; Birur, Gajanana; Prina, Mauro; Ramirez, Brenda; Paris, Anthony; Novak, Keith; Pauken, Michael

2006-01-01

This viewgraph presentation reviews the heat rejection and heat recovery system for thermal control of the Mars Science Laboratory (MSL). The MSL mission will use mechanically pumped fluid loop based architecture for thermal control of the spacecraft and rover. The architecture is designed to harness waste heat from an Multi Mission Radioisotope Thermo-electric Generator (MMRTG) during Mars surface operations for thermal control during cold conditions and also reject heat during the cruise aspect of the mission. There are several test that are being conducted that will insure the safety of this concept. This architecture can be used during any future interplanetary missions utilizing radioisotope power systems for power generation.

Design of energy harvesting systems for harnessing vibrational motion from human and vehicular motion

NASA Astrophysics Data System (ADS)

Wickenheiser, Adam; Garcia, Ephrahim

2010-04-01

In much of the vibration-based energy harvesting literature, devices are modeled, designed, and tested for dissipating energy across a resistive load at a single base excitation frequency. This paper presents several practical scenarios germane to tracking, sensing, and wireless communication on humans and land vehicles. Measured vibrational data from these platforms are used to provide a time-varying, broadband input to the energy harvesting system. Optimal power considerations are given for several circuit topologies, including a passive rectifier circuit and active, switching methods. Under various size and mass constraints, the optimal design is presented for two scenarios: walking and idling a car. The frequency response functions are given alongside time histories of the power harvested using the experimental base accelerations recorded. The issues involved in designing an energy harvester for practical (i.e. timevarying, non-sinusoidal) applications are discussed.

Fabrication and physical testing of graphite composite panels utilizing woven graphite fabric with current and advanced state-of-the-art resin systems

NASA Technical Reports Server (NTRS)

Lee, S. C. S.

1979-01-01

Three weaves were evaluated; a balanced plain weave, a balanced 8-harness satin weave, and a semiunidirectional crowfoot satin weave. The current state-of-the-art resin system selected was Fiberite's 934 Epoxy; the advanced resin systems evaluated were Phenolic, Phenolic/Novolac, Benzyl and Bismaleimide. The panels were fabricated for testing on NASA/Ames Research Center's Composites Modification Program. Room temperature mechanical tests only were performed by Hitco; the results are presented.

KSC-07pd3649

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, the wiring is checked and validated before the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3644

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, a technician sets up wiring for the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3651

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, the wiring is checked and validated before the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3648

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, the wiring is checked and validated before the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3647

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, the wiring is checked and validated before the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3650

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, the wiring is checked and validated before the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3645

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, a wiring board has been set up for the tanking test on space shuttle Atlantis' external tank set for Dec. 18. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

KSC-07pd3646

NASA Image and Video Library

2007-12-15

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, a technician checks the blue monitor that will be used to validate the circuit on test wiring during the tanking test on space shuttle Atlantis' external tank. The test wiring has been spliced into an electrical harness in the aft main engine compartment connected with the engine cut-off, or ECO, sensor system. The attached wiring leads to the interior of the mobile launcher platform where the time domain reflectometry, or TDR, test equipment is located. Photo credit: NASA/Kim Shiflett

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

14 CFR 29.2 - Special retroactive requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... be protected from serious head injury by a safety belt plus a shoulder harness that will prevent the... equipped with a safety belt and shoulder harness that meets the requirements of paragraphs (a), (b), and (c) of this section. (a) Each occupant's seat must have a combined safety belt and shoulder harness with...

Harnessing the Power of Information Technology: Open Business Models in Higher Education

ERIC Educational Resources Information Center

Sheets, Robert G.; Crawford, Stephen

2012-01-01

Higher education is under enormous pressure to improve outcomes and reduce costs. Information technology can help achieve these goals, but only if it is properly harnessed. This article argues that one key to harnessing information technology is business model innovation that results in more "open" and "unbundled" operations in learning and…

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Shoulder harness installation at flight... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight... configuration, excluding any pilot seat, of 10 seats or more unless it is equipped with an approved shoulder...

78 FR 57784 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-20

... certain wire harness located in the tail cone has wiring of a narrower gauge than design requires. This AD requires replacing the affected wire harness. We are issuing this AD to prevent damage to the affected... production aeroplane, it has been discovered that wires in harness 5877VB, installed in the Tail Cone...

75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... pump wire harness assembly is routed within the tire burst area and that installing and routing a new and longer auxiliary hydraulic pump wire harness assembly outside the tire burst area will minimize... general visual inspection of the wire harness protective sleeving dimensions, which are related...

Balance measured by the sway balance smart-device application does not discriminate between older persons with and without a fall history.

PubMed

Vincenzo, Jennifer L; Glenn, Jordan M; Gray, Stephanie M; Gray, Michelle

2016-08-01

Clinical functional assessments of balance often lack specificity and sensitivity in discriminating and predicting falls among community-dwelling older adults. We determined the feasibility of using a smart-device application measuring balance to discriminate fall status among older adults. We also evaluated differences between smart-device balance measurements when secured with or without a harness. A cross-sectional study design to determine the ability of the Sway Balance smart-device application (SWAY) to discriminate older adults based on fall history. The Berg Balance Scale (BBS) and Activities-Specific Balance Confidence Scale (ABC) were used as comparative, clinically based assessments. Community-dwelling older adults with (n = 25) and without (n = 32) a history of fall(s) participated. Multivariate analysis of variance was used to determine differences among assessments based on fall history. Logistic regression models determined the ability of each assessment to discriminate fall history. Older adults with and without a history of falls were not significantly different on SWAY (P = 0.92) but were different on BBS (P = 0.01), and ABC (P < 0.001). Similarly, SWAY did not discriminate fall history (P = 0.92), while BBS and ABC both discriminated fall history (P < 0.01). Paired t tests between SWAY scores with and without a harness indicated no differences (P ≥ 0.05). Among the older adults studied, the BBS and ABC measures discriminated groups defined by fall history, while the SWAY smart-device balance application did not. Modifications to the application may improve the discriminating ability of the measure in the recognition of fall status in older adults.

Detection of an abundant plant-based small RNA in consumers

USDA-ARS?s Scientific Manuscript database

Mechanisms of delivery of plant small RNAs to consumers must be addressed in order to harness this technology to positively impact agbiotechnology. Two groups have used honeysuckle (Lonicera japonica) feeding regimes to detect a plant-based small RNA, termed MIR2911, in sera. Meanwhile, numerous gro...

Testing a potential national strategy for cost-effective medical technology

NASA Astrophysics Data System (ADS)

Fitch, J. Patrick

1995-10-01

The Center for Healthcare Technologies at Lawrence Livermore National Laboratory is a partnership among government, industry, and universities that focuses on improving healthcare through development of cost-effective technology. With the guidance of healthcare providers, medical institutions, and medical instrument manufacturers, technology can be harnessed to reduce healthcare costs. The partnership is a miniature test case for a potential national strategy for development and adoption of technology specifically to reduce costs.

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... head injury by a safety belt plus a shoulder harness that will prevent the head from contacting any injurious object except as provided for in § 27.562(c)(5). A shoulder harness (upper torso restraint), in... serious injury in an emergency landing as a result of the static inertial load factors specified in § 27...

75 FR 47201 - Airworthiness Directives; Eurocopter France Model EC 130 B4 Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

... each electrical harness for chaffing, tears, holes, or other damage at the location of each attachment... electrical harness for any chaffing, tear, hole, or other damage at the location of each attachment screw and... harness for chaffing, a tear, a hole, or other damage at the location of each attachment screw as depicted...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of safety belts, shoulder harnesses... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child... board is briefed on how to fasten and unfasten that person's safety belt and, if installed, shoulder...

75 FR 30274 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... installed on wire harnesses of the tail tank fuel transfer pumps, and to determine if damaged wires are... a permanent modification of the wire harnesses if metallic transitions are not installed, which... harnesses of the tail tank fuel transfer pumps, and to determine if damaged wires are present; and repair...

75 FR 81433 - Airworthiness Directives; Airbus Model A321-211, -212, -231, and -232 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... join individual electrical wires in the Wing Tank harness installations to in-tank equipment on QT... are used to join individual electrical wires in the Wing Tank harness installations to in-tank... electrical wires in the Wing Tank harness installations to in-tank equipment on QT circuit. The failure of a...

weCare: A social media-based intervention designed to increase HIV care linkage, retention, and health outcomes for racially and ethnically diverse young MSM

PubMed Central

Tanner, Amanda E.; Mann, Lilli; Song, Eunyoung; Alonzo, Jorge; Schafer, Katherine; Arellano, Elías; Garcia, Jesus M.; Rhodes, Scott D.

2016-01-01

Estimates suggest that only about 30% of all individuals living with HIV in the US have achieved viral suppression. Men who have sex with men (MSM), particularly racial/ethnic minority young MSM, are at increased risk for HIV infection and may have even lower viral suppression rates. HIV testing rates among MSM are low, and when tested, racial/ethnic minority young MSM have disproportionately lower rates of retention in care and viral suppression compared to other subgroups. This paper describes the design and development of weCare, our social media-based intervention to improve care linkage and retention and health outcomes among racially and ethnically diverse MSM, ages 13–34, living with HIV that will be implemented and evaluated beginning in late 2016. The intervention harnesses established social media that MSM between these ages commonly use, including Facebook, text messaging, and established GPS-based mobile applications (“apps”). We are using community-based participatory research (CBPR) to enhance the quality and validity of weCare, equitably involving community members, organization representatives, healthcare providers, clinic staff, and academic researchers. PMID:27244190

weCARE: A Social Media-Based Intervention Designed to Increase HIV Care Linkage, Retention, and Health Outcomes for Racially and Ethnically Diverse Young MSM.

PubMed

Tanner, Amanda E; Mann, Lilli; Song, Eunyoung; Alonzo, Jorge; Schafer, Katherine; Arellano, Elías; Garcia, Jesus M; Rhodes, Scott D

2016-06-01

Estimates suggest that only about 30% of all individuals living with HIV in the U.S. have achieved viral suppression. Men who have sex with men (MSM), particularly racial/ethnic minority young MSM, are at increased risk for HIV infection and may have even lower viral suppression rates. HIV testing rates among MSM are low, and when tested, racial/ethnic minority young MSM have disproportionately lower rates of retention in care and viral suppression compared to other subgroups. This article describes the design and development of weCare, our social media-based intervention to improve care linkage and retention and health outcomes among racially and ethnically diverse MSM, ages 13-34, living with HIV that will be implemented and evaluated beginning in late 2016. The intervention harnesses established social media that MSM between these ages commonly use, including Facebook, text messaging, and established GPS-based mobile applications (apps). We are using community-based participatory research (CBPR) to enhance the quality and validity of weCare, equitably involving community members, organization representatives, healthcare providers, clinic staff, and academic researchers.

75 FR 3783 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

...: Government-wide rulemaking Web site: Go to http://www.regulations.gov and follow the instructions for sending... any personal information you provide. Using the search function of our docket Web site, anyone can... landing dynamic conditions. Cubcrafters proposes the use of static tests on the seat and harnesses and to...

42 CFR 84.151 - Harness test; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... withstand a pull of 113 kg. (250 pounds) for 30 minutes without failure. (2) Belts, rings, and attachments... minutes without separating, and the hose attachments shall be arranged so that the pull or drag of the... attachment of the line shall permit dragging the maximum length of hose considered for approval over a...

Harnessing dendritic cells in inflammatory skin diseases

PubMed Central

Chu, Chung-Ching; Di Meglio, Paola; Nestle, Frank O.

2011-01-01

The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. PMID:21295490

KSC-07pd3660

NASA Image and Video Library

2007-12-29

KENNEDY SPACE CENTER, FLA. -- At Launch Pad 39A, a team of external tank specialists from Lockheed Martin and the United Space Alliance undertakes the task of removing the hydrogen feed-through connector in support of space shuttle Atlantis' STS-122 mission. Here, a technician pulls the connector assembly, with its associated electrical harness, away from the tank. Some of the tank's engine cutoff sensors, or ECO sensors, failed during propellant tanking for launch attempts on Dec. 6 and Dec. 9. Results of a tanking test on Dec. 18 pointed to an open circuit in the feed-through connector wiring, which is located at the base of the tank. The feed-through connector passes the wires from the inside of the tank to the outside. After the data from additional testing on the connector is analyzed, shuttle program managers will decide on a forward plan. Launch of STS-122 is targeted for January 2008. Photo credit: NASA/George Shelton

Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo

PubMed Central

Bilibana, Mawethu Pascoe; Yeoh, Tzi Shien; Tang, Thean-Hock

2017-01-01

The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application. One promising avenue that is currently explored based on the specificity and affinity of aptamers is the application of aptamers in the decontamination assays. Aptamers have been successfully harnessed as the decontamination agents to remove contaminants from the environment and to decontaminate infectious elements. The reversible denaturation property inherent in aptamers enables the repeated usage of aptamers, which can immensely save the cost of decontamination. Analogous to the point-of-care diagnostics, there is no doubt that aptamers can also be deployed in the point-of-care aptamer-based decontamination assay, whereby decontamination can be performed anywhere and anytime for instantaneous decision-making. It is also prophesied that aptamers can also serve more than as a decontaminant, probably as a tool to capture and kill hazardous elements, particularly pathogenic agents. PMID:29225967

PDS4: Harnessing the Power of Generate and Apache Velocity

NASA Astrophysics Data System (ADS)

Padams, J.; Cayanan, M.; Hardman, S.

2018-04-01

The PDS4 Generate Tool is a Java-based command-line tool developed by the Cartography and Imaging Sciences Nodes (PDSIMG) for generating PDS4 XML labels, from Apache Velocity templates and input metadata.

The validity and reliability of a customized rigid supportive harness during Smith machine back squat exercise.

PubMed

Scott, Brendan R; Dascombe, Ben J; Delaney, Jace A; Elsworthy, Nathan; Lockie, Robert G; Sculley, Dean V; Slattery, Katie M

2014-03-01

Although the back squat exercise is commonly prescribed to both athletic and clinical populations, individuals with restricted glenohumeral mobility may be unable to safely support the bar on the upper trapezius using their hands. The aims of this study were to investigate the validity and reliability of a back squat variation using a rigid supportive harness that does not require unrestricted glenohumeral mobility for quantifying 1 repetition maximum (1RM). Thirteen young men (age = 25.3 ± 4.5 years, height = 179.2 ± 6.9 cm, and body mass = 86.6 ± 12.0 kg) with at least 2 years resistance training experience volunteered to participate in the study. Subjects reported to the lab on 3 occasions, each separated by 1 week. During testing sessions, subjects were assessed for 1RM using the traditional back squat (session 1) and harness back squat (HBS; sessions 2 and 3) exercises. Mean 1RM for the traditional back squat, and 2 testing sessions of the HBS (HBS1 and HBS2) were 148.4 ± 25.0 kg, 152.5 ± 25.7 kg, and 150.4 ± 22.6 kg, respectively. Back squat and mean HBS 1RM scores were very strongly correlated (r = 0.96; p < 0.001). There were no significant differences in 1RM scores between the 3 trials. The test-retest 1RM scores with the HBS demonstrated high reliability, with an intraclass correlation coefficient of 0.98 (95% confidence interval [CI] = 0.93-0.99), and a coefficient of variation of 2.6% (95% CI = 1.9-4.3). Taken together, these data suggest that the HBS exercise is a valid and reliable method for assessing 1RM in young men with previous resistance training experience and may be useful for individuals with restricted glenohumeral mobility.

Alternative Fuels Data Center: Fair Oaks Farm Harnesses the Power of

Science.gov Websites

Natural Gas from Cow Manure Fair Oaks Farm Harnesses the Power of Natural Gas from Cow Manure Natural Gas from Cow Manure on Facebook Tweet about Alternative Fuels Data Center: Fair Oaks Farm Harnesses the Power of Natural Gas from Cow Manure on Twitter Bookmark Alternative Fuels Data Center: Fair

75 FR 28478 - Airworthiness Directives; Eurocopter France (ECF) Model AS332L1 and AS332L2 Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... fully tilted the seat shoulder harness could become jammed between the seat and bulkhead. This condition, if not corrected, could result in the shoulder harness binding and causing the inertial reel to... seat backrest is fully tilted, there is a risk of the shoulder harness jamming between the seat and...

75 FR 20423 - Fuji Heavy Industries USA, Inc., Receipt of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... power supply to the lamp. The Company said that ``installation of the wiring harness to the... subsupplier such that tension was put on the wiring harness connector'' which can cause it to come loose. To correct this problem, the Company has re-routed the wiring harness to ``push'' rather than ``pull'' on the...

Reliability and Validity of the Zephyr[TM] BioHarness[TM] to Measure Respiratory Responses to Exercise

ERIC Educational Resources Information Center

Hailstone, Jono; Kilding, Andrew E.

2011-01-01

The Zephyr[TM] BioHarness[TM] (Zephyr Technology, Auckland, New Zealand) is a wireless physiological monitoring system that has the ability to measure respiratory rate unobtrusively. However, the ability of the BioHarness[TM] to accurately and reproducibly determine respiratory rate across a range of intensities is currently unknown. The aim of…

Wire harness twisting aid

NASA Technical Reports Server (NTRS)

Casey, E. J.; Commadore, C. C.; Ingles, M. E.

1980-01-01

Long wire bundles twist into uniform spiral harnesses with help of simple apparatus. Wires pass through spacers and through hand-held tool with hole for each wire. Ends are attached to low speed bench motor. As motor turns, operator moves hand tool away forming smooth twists in wires between motor and tool. Technique produces harnesses that generate less radio-frequency interference than do irregularly twisted cables.

Circuit For Control Of Electromechanical Prosthetic Hand

NASA Technical Reports Server (NTRS)

Bozeman, Richard J., Jr.

1995-01-01

Proposed circuit for control of electromechanical prosthetic hand derives electrical control signals from shoulder movements. Updated, electronic version of prosthesis, that includes two hooklike fingers actuated via cables from shoulder harness. Circuit built around favored shoulder harness, provides more dexterous movement, without incurring complexity of computer-controlled "bionic" or hydraulically actuated devices. Additional harness and potentiometer connected to similar control circuit mounted on other shoulder. Used to control stepping motor rotating hand about prosthetic wrist to one of number of angles consistent with number of digital outputs. Finger-control signals developed by circuit connected to first shoulder harness transmitted to prosthetic hand via sliprings at prosthetic wrist joint.

Cryo-Vacuum Testing of the JWST Integrated Science Instrument Module

NASA Technical Reports Server (NTRS)

Kimble, Randy A.; Vila, M. Begona; Van Campen, Julie M.; Birkmann, Stephen M.; Comber, Brian J.; Fatig, Curtis C.; Glasse, Alistair C. H.; Glazer, Stuart D.; Kelly, Douglas M.; Mann, Steven D.;

Integrating Cloud-Based Strategies and Tools in Face-to-Face Training Sessions to Increase the Impact of Professional Development

ERIC Educational Resources Information Center

Gradel, Kathleen; Edson, Alden J.

2012-01-01

This article is based on the premise that face-to-face training can be augmented with cloud-based technology tools, to potentially extend viable training supports as higher education staff and faculty implement new content/skills in their jobs and classrooms. There are significant benefits to harnessing cloud-based tools that can facilitate both…

Analyzing Systems Integration Best Practices and Assessment in DoD Space Systems Acquisition

DTIC Science & Technology

2009-12-01

satellite  Insufficient stress relief and insulation caused abrasion of wiring harness. C Product–Product: stress relief and insulation – wiring...delaminated during firing . This problem escaped qualification since slow heating rates (0.1–deg F/sec) used in the lab test provided time for the gas...to escape. Faster rates would have revealed the issue. E Product–Process: material – replace, firing ; rate – test B Process–Process: replace

A systematic review of the main mechanisms of heart failure disease management interventions.

PubMed

Clark, Alexander M; Wiens, Kelly S; Banner, Davina; Kryworuchko, Jennifer; Thirsk, Lorraine; McLean, Lianne; Currie, Kay

2016-05-01

To identify the main mechanisms of heart failure (HF) disease management programmes based in hospitals, homes or the community. Systematic review of qualitative and quantitative studies using realist synthesis. The search strategy incorporated general and specific terms relevant to the research question: HF, self-care and programmes/interventions for HF patients. To be included, papers had to be published in English after 1995 (due to changes in HF care over recent years) to May 2014 and contain specific data related to mechanisms of effect of HF programmes. 10 databases were searched; grey literature was located via Proquest Dissertations and Theses, Google and publications from organisations focused on HF or self-care. 33 studies (n=3355 participants, mean age: 65 years, 35% women) were identified (18 randomised controlled trials, three mixed methods studies, six pre-test post-test studies and six qualitative studies). The main mechanisms identified in the studies were associated with increased patient understanding of HF and its links to self-care, greater involvement of other people in this self-care, increased psychosocial well-being and support from health professionals to use technology. Future HF disease management programmes should seek to harness the main mechanisms through which programmes actually work to improve HF self-care and outcomes, rather than simply replicating components from other programmes. The most promising mechanisms to harness are associated with increased patient understanding and self-efficacy, involvement of other caregivers and health professionals and improving psychosocial well-being and technology use. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.

PubMed

Saas, Philippe; Kaminski, Sandra; Perruche, Sylvain

2013-10-01

Apoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects. While the involved immune mechanisms are still being deciphered, apoptotic cell infusion has been tested in different experimental models where inflammation is deregulated. This includes chronic and acute inflammatory disorders such as arthritis, contact hypersensitivity and acute myocardial infarction. Apoptotic cell infusion has also been used in transplantation settings to prevent or treat acute and chronic rejection, as well as to limit acute graft-versus-host disease associated with allogeneic hematopoietic cell transplantation. Here, we review the mechanisms involved in apoptotic cell-induced immunomodulation and data obtained in preclinical models of transplantation and inflammatory diseases.

Joint helmet-mounted cueing system (JHMCS) helmet qualification testing requirements

NASA Astrophysics Data System (ADS)

Orf, Garry W.

1998-08-01

The Joint Helmet-Mounted Cueing System (JHMCS) program will provide capability to cue high off-boresight (HOBS) weapons to the operator's line of sight and to confirm weapon sensor LOS for the US Air Force and US Navy (USN) aircrew. This capability will ensure the USAF and USN pilots a first shot opportunity. The JHMCS incorporates an ejection-compatible helmet-mounted display system that will be installed on F- 15, F-16, F/A-18, and F-22 aircraft. The JHMCS includes a flight helmet with display optics, miniature cathode ray tube, magnetic receiver unit, miniature camera, automatic brightness control sensor, and microcontroller. The flight helmet for JHMCS is based on the new lightweight HGU-55A/P. This paper describes the requirements for the helmet qualification tests including: windblast, ejection tower, hanging harness, centrifuge, mass properties, energy attenuation and penetration resistance, noise attenuation, visor characteristics, compatibility demonstration, sled/in- flight ejection, water survival, standard conditions and environment. The test objective, success criteria, equipment configuration, and data collection requirements for each test is discussed.

Project Volunteer Power: Volunteers Serving the Job Needs of the Handicapped. Final Report.

ERIC Educational Resources Information Center

President's Committee on Employment of the Handicapped, Washington, DC.

The report covers the activities, results, and lessons learned in a project to test a new approach in developing greater opportunities in employment of the physically handicapped, mentally retarded, and mentally restored by harnessing the resources of leading volunteer women's organizations at the local level on a practical, planned basis. Project…

Fighting liver cancer with combination immunotherapies | Center for Cancer Research

Cancer.gov

A new clinical trial testing the effectiveness of immunotherapy treatment combinations against liver cancer is enrolling patients at the NIH Clinical Center in Bethesda, Maryland. Individually, immunotherapy drugs harness the power of the human immune system to better identify and kill cancer cells. Now, researchers at the NIH’s Center for Cancer Research have begun to find

Nuffield Secondary Science, Theme 4, Harnessing Energy.

ERIC Educational Resources Information Center

Howard, Edgar

Nuffield Secondary Science is a set of tested materials from which teachers can prepare courses for students in grades 9-11 (approximately) who do not intend to major in science. The materials are designed for British secondary schools but are adaptable to other countries. The Teachers' Guide to the entire set of Themes is described in SE 015 440…

Forecasting the value-at-risk of Chinese stock market using the HARQ model and extreme value theory

NASA Astrophysics Data System (ADS)

Liu, Guangqiang; Wei, Yu; Chen, Yongfei; Yu, Jiang; Hu, Yang

2018-06-01

Using intraday data of the CSI300 index, this paper discusses value-at-risk (VaR) forecasting of the Chinese stock market from the perspective of high-frequency volatility models. First, we measure the realized volatility (RV) with 5-minute high-frequency returns of the CSI300 index and then model it with the newly introduced heterogeneous autoregressive quarticity (HARQ) model, which can handle the time-varying coefficients of the HAR model. Second, we forecast the out-of-sample VaR of the CSI300 index by combining the HARQ model and extreme value theory (EVT). Finally, using several popular backtesting methods, we compare the VaR forecasting accuracy of HARQ model with other traditional HAR-type models, such as HAR, HAR-J, CHAR, and SHAR. The empirical results show that the novel HARQ model can beat other HAR-type models in forecasting the VaR of the Chinese stock market at various risk levels.

A Regulatory Pathway, Ecdysone-Transcription Factor Relish-Cathepsin L, Is Involved in Insect Fat Body Dissociation

PubMed Central

Zhang, Yao; Lu, Yu-Xuan; Liu, Jian; Yang, Cui; Feng, Qi-Li; Xu, Wei-Hua

2013-01-01

Insect fat body is the organ for intermediary metabolism, comparable to vertebrate liver and adipose tissue. Larval fat body is disintegrated to individual fat body cells and then adult fat body is remodeled at the pupal stage. However, little is known about the dissociation mechanism. We find that the moth Helicoverpa armigera cathepsin L (Har-CL) is expressed heavily in the fat body and is released from fat body cells into the extracellular matrix. The inhibitor and RNAi experiments demonstrate that Har-CL functions in the fat body dissociation in H. armigera. Further, a nuclear protein is identified to be transcription factor Har-Relish, which was found in insect immune response and specifically binds to the promoter of Har-CL gene to regulate its activity. Har-Relish also responds to the steroid hormone ecdysone. Thus, the dissociation of the larval fat body is involved in the hormone (ecdysone)-transcription factor (Relish)-target gene (cathepsin L) regulatory pathway. PMID:23459255

Effect of simulated weightlessness on energy metabolism in the rat

NASA Technical Reports Server (NTRS)

Jordan, J. P.; Sykes, H. A.; Crownover, J. C.; Schatte, C. L.; Simmons, J. B., II; Jordan, D. P.

1982-01-01

Results of measurements of food uptake and body weight changes occurring in rats suspended from a harness so that the antigravity muscles were not used for locomotion are presented. The rats were tested in pairs, with both in a harness but only one suspended off its hind legs; this section lasted 7 days. A second phase of the experiment involved feeding the nonsuspended rat the same amount of food the experimental rat had consumed the previous day. All rats experienced decreased in body weight and food intake in the first stage, while in the second stage the suspended rat lost more weight. The total oxygen uptake, CO2 output, and rate of C-14O2 production were depressed in the suspended rats, then returned to normal levels once the rats were back on the ground. It is concluded that the gross metabolic processes are unaffected by simulated weightlessness.

Harnessing supramolecular peptide nanotechnology in biomedical applications.

PubMed

Chan, Kiat Hwa; Lee, Wei Hao; Zhuo, Shuangmu; Ni, Ming

2017-01-01

The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected.

Hybrid air revitalization system for a closed ecosystem

NASA Technical Reports Server (NTRS)

Lee, M. G.; Brown, Mariann F.

1990-01-01

An air-revitalization concept is presented with experimental results to assess the practicality and applicability of the proposed system to extended-duration manned missions. The Hybrid Air Revitalization System (HARS) uses plants in a habitat to remove metabolic CO2 and moisture and produce oxygen and food. CO2 and O2 partial pressures, temperature, and humidity are regulated by means of electrochemical CO2 and O2 chemical separators and a moisture condenser separator. A cell-test facility is described in which the electrochemical CO2 removal processes are investigated with and without using H2. Performance is optimized by using 25-30 percent Teflon in the gas-diffusion-type electrode, employing a thin electrolyte matrix, operating at higher temperatures and lower dew points. The HARS concept is found to be a feasible approach to the electrochemical separation of CO2 and O2.

Harnessing dendritic cells in inflammatory skin diseases.

PubMed

Chu, Chung-Ching; Di Meglio, Paola; Nestle, Frank O

2011-02-01

The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. Copyright © 2011 Elsevier Ltd. All rights reserved.

Towards the development of a hybrid-integrated chip interferometer for online surface profile measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, P.; Martin, H.; Jiang, X.

Non-destructive testing and online measurement of surface features are pressing demands in manufacturing. Thus optical techniques are gaining importance for characterization of complex engineering surfaces. Harnessing integrated optics for miniaturization of interferometry systems onto a silicon wafer and incorporating a compact optical probe would enable the development of a handheld sensor for embedded metrology applications. In this work, we present the progress in the development of a hybrid photonics based metrology sensor device for online surface profile measurements. The measurement principle along with test and measurement results of individual components has been presented. For non-contact measurement, a spectrally encoded lateralmore » scanning probe based on the laser scanning microscopy has been developed to provide fast measurement with lateral resolution limited to the diffraction limit. The probe demonstrates a lateral resolution of ∼3.6 μm while high axial resolution (sub-nanometre) is inherently achieved by interferometry. Further the performance of the hybrid tuneable laser and the scanning probe was evaluated by measuring a standard step height sample of 100 nm.« less

Harnessing the Power of Light to See and Treat Breast Cancer

DTIC Science & Technology

2010-10-01

Harnessing the power of light to see and treat breast cancer PRINCIPAL INVESTIGATOR: Nirmala Ramanujam, Ph.D...NUMBER Harnessing the power of light to see and treat breast cancer . 5b. GRANT NUMBER W81XWH-09-1-0410 5c. PROGRAM ELEMENT NUMBER 6...optical contrast to develop novel strategies that focus on two breast cancer applications: tumor margin assessment and prediction of response to neo

Advances and limitations of visual conditioning protocols in harnessed bees.

PubMed

Avarguès-Weber, Aurore; Mota, Theo

2016-10-01

Bees are excellent invertebrate models for studying visual learning and memory mechanisms, because of their sophisticated visual system and impressive cognitive capacities associated with a relatively simple brain. Visual learning in free-flying bees has been traditionally studied using an operant conditioning paradigm. This well-established protocol, however, can hardly be combined with invasive procedures for studying the neurobiological basis of visual learning. Different efforts have been made to develop protocols in which harnessed honey bees could associate visual cues with reinforcement, though learning performances remain poorer than those obtained with free-flying animals. Especially in the last decade, the intention of improving visual learning performances of harnessed bees led many authors to adopt distinct visual conditioning protocols, altering parameters like harnessing method, nature and duration of visual stimulation, number of trials, inter-trial intervals, among others. As a result, the literature provides data hardly comparable and sometimes contradictory. In the present review, we provide an extensive analysis of the literature available on visual conditioning of harnessed bees, with special emphasis on the comparison of diverse conditioning parameters adopted by different authors. Together with this comparative overview, we discuss how these diverse conditioning parameters could modulate visual learning performances of harnessed bees. Copyright © 2016 Elsevier Ltd. All rights reserved.

KSC-2011-7015

NASA Image and Video Library

2011-08-30

VANDENBERG AIR FORCE BASE, Calif. – In the Astrotech Payload Processing Facility at Vandenberg Air Force Base in California, technicians remove the lifting crane and harnesses from the container holding NASA’s National Polar-orbiting Operational Environmental Satellite System Preparatory Project (NPP). NPP represents a critical first step in building the next-generation of Earth-observing satellites. NPP will carry the first of the new sensors developed for this satellite fleet, now known as the Joint Polar Satellite System (JPSS), to be launched in 2016. NPP is the bridge between NASA’s Earth Observing System (EOS) satellites and the forthcoming series of JPSS satellites. The mission will test key technologies and instruments for the JPSS missions. NPP is targeted to launch Oct. 25 from Space Launch Complex-2 aboard a United Launch Alliance Delta II rocket. For more information, visit http://www.nasa.gov/NPP. Photo credit: NASA/30th Communications Squadron, VAFB

Suited and Unsuited Hybrid III Impact Testing and Finite Element Model Characterization

NASA Technical Reports Server (NTRS)

Lawrence, C.; Somers, J. T.; Baldwin, M. A.; Wells, J. A.; Newby, N.; Currie, N. J.

2016-01-01

NASA spacecraft design requirements for occupant protection are a combination of the Brinkley Dynamic Response Criteria and injury assessment reference values (IARV) extracted from anthropomorphic test devices (ATD). For the ATD IARVs, the requirements specify the use of the 5th percentile female Hybrid III and the 95th percentile male Hybrid III. Each of these ATDs is required to be fitted with an articulating pelvis (also known as the aerospace pelvis) and a straight spine. The articulating pelvis is necessary for the ATD to fit into spacecraft seats, while the straight spine is required as injury metrics for vertical accelerations are better defined for this configuration. Sled testing of the Hybrid III 5th Percentile Female Anthropomorphic Test Device (ATD) was performed at Wright-Patterson Air Force Base (WAPFB). Two 5th Percentile ATDs were tested, the Air Force Research Lab (AFRL) and NASA owned Hybrid III ATDs with aerospace pelvises. Testing was also conducted with a NASA-owned 95th Percentile Male Hybrid III with aerospace pelvis at WPAFB. Testing was performed using an Orion seat prototype provided by Johnson Space Center (JSC). A 5-point harness comprised of 2 inch webbing was also provided by JSC. For suited runs, a small and extra-large Advanced Crew Escape System (ACES) suit and helmet were also provided by JSC. Impact vectors were combined frontal/spinal and rear/lateral. Some pure spinal and rear axis testing was also performed for model validation. Peak accelerations ranged between 15 and 20-g. This range was targeted because the ATD responses fell close to the IARV defined in the Human-Systems Integration Requirements (HSIR) document. Rise times varied between 70 and 110 ms to assess differences in ATD responses and model correlation for different impact energies. The purpose of the test series was to evaluate the Hybrid III ATD models in Orion-specific landing orientations both with and without a spacesuit. The results of these tests were used by the NASA Engineering and Safety Center (NESC) to validate the finite element model (FEM) of the Hybrid III 5th Percentile Female ATD. Physical test data was compared to analytical predictions from simulations, and modelling uncertainty factors have been determined for each injury metric. Additionally, the test data has been used to further improve the FEM, particularly in the areas of the ATD preload, harness, and suit and helmet effects.

The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.

PubMed

Abbott, Jamie A; Guth, Ethan; Kim, Cindy; Regan, Cathy; Siu, Victoria M; Rupar, C Anthony; Demeler, Borries; Francklyn, Christopher S; Robey-Bond, Susan M

2017-07-18

Histidyl-tRNA synthetase (HARS) is a highly conserved translation factor that plays an essential role in protein synthesis. HARS has been implicated in the human syndromes Charcot-Marie-Tooth (CMT) Type 2W and Type IIIB Usher (USH3B). The USH3B mutation, which encodes a Y454S substitution in HARS, is inherited in an autosomal recessive fashion and associated with childhood deafness, blindness, and episodic hallucinations during acute illness. The biochemical basis of the pathophysiologies linked to USH3B is currently unknown. Here, we present a detailed functional comparison of wild-type (WT) and Y454S HARS enzymes. Kinetic parameters for enzymes and canonical substrates were determined using both steady state and rapid kinetics. Enzyme stability was examined using differential scanning fluorimetry. Finally, enzyme functionality in a primary cell culture was assessed. Our results demonstrate that the Y454S substitution leaves HARS amino acid activation, aminoacylation, and tRNA His binding functions largely intact compared with those of WT HARS, and the mutant enzyme dimerizes like the wild type does. Interestingly, during our investigation, it was revealed that the kinetics of amino acid activation differs from that of the previously characterized bacterial HisRS. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than WT HARS, and cells from Y454S patients grown at elevated temperatures demonstrate diminished levels of protein synthesis compared to those of WT cells. The thermal sensitivity associated with the Y454S mutation represents a biochemical basis for understanding USH3B.

Minimizing marker mass and handling time when attaching radio-transmitters and geolocators to small songbirds

USGS Publications Warehouse

Streby, Henry M.; McAllister, Tara L.; Peterson, Sean M.; Kramer, Gunnar R.; Lehman, Justin A.; Andersen, David E.

2015-01-01

Radio-transmitters and light-level geolocators are currently small enough for use on songbirds weighing <15 g. Various methods are used to attach these markers to larger songbirds, but with small birds it becomes especially important to minimize marker mass and bird handling time. Here, we offer modifications to harness materials and marker preparation for transmitters and geolocators, and we describe deployment methods that can be safely completed in 20–60 s per bird. We describe a 0.5-mm elastic sewing thread harness for radio-transmitters that allows nestlings, fledglings, and adults to be marked with the same harness size and reliably falls off to avoid poststudy effects. We also describe a 0.5-mm jewelry cord harness for geolocators that provides a firm fit for >1 yr. Neither harness type requires plastic or metal tubes, rings, or other attachment fixtures on the marker, nor do they require crimping beads, epoxy, scissors, or tying knots while handling birds. Both harnesses add 0.03 g to the mass of markers for small wood-warblers (Parulidae). This minimal additional mass is offset by trimming transmitter antennas or geolocator connection nodes, resulting in no net mass gain for transmitters and 0.02 g added for geolocators compared with conventional harness methods that add >0.40 g. We and others have used this transmitter attachment method with several small songbird species, with no effects on adult and fledgling behavior and survival. We have used this geolocator attachment method on 9-g wood-warblers with no effects on return rates, return dates, territory fidelity, and body mass. We hope that these improvements to the design and deployment of the leg-loop harness method will enable the safe and successful use of these markers, and eventually GPS and other tags, on similarly small songbirds.

Cryogenic on-orbit liquid depot storage acquisition and transfer (COLD-SAT) experiment subsystem instrumentation and wire harness design report

NASA Technical Reports Server (NTRS)

Edwards, Lawrence G.

1994-01-01

Subcritical cryogens such as liquid hydrogen (LH2) and liquid oxygen (LO2) are required for space based transportation propellant, reactant, and life support systems. Future long-duration space missions will require on-orbit systems capable of long-term cryogen storage and efficient fluid transfer capabilities. COLD-SAT, which stands for cryogenic orbiting liquid depot-storage acquisition and transfer, is a free-flying liquid hydrogen management flight experiment. Experiments to determine optimum methods of fluid storage and transfer will be performed on the COLD-SAT mission. The success of the mission is directly related to the type and accuracy of measurements made. The instrumentation and measurement techniques used are therefore critical to the success of the mission. This paper presents the results of the COLD-SAT experiment subsystem instrumentation and wire harness design effort. Candidate transducers capable of fulfilling the COLD-SAT experiment measurement requirements are identified. Signal conditioning techniques, data acquisition requirements, and measurement uncertainty analysis are presented. Electrical harnessing materials and wiring techniques for the instrumentation designed to minimize heat conduction to the cryogenic tanks and provide optimum measurement accuracy are listed.

Safety Assessment of TACOM’s Ride Motion Simulator

DTIC Science & Technology

1990-01-24

level (1300 to 1800 psi). 24 Step 16. Pressurize the system by moving the main pressure switch to "ON." Wait for the roll, pitch, and yaw error signals...the appropriate seat/shoulder/safety belts and harnesses. Carefully, help the test subject dismount. Step 41. Flip the main pressure switch on the...Dismount the test subject. Step 6. Move the main pressure switch to the "OFF" position. This will block any hydraulic flow to the system. Step 7. Move the

Ceramic Matrix Composite Characterization Under a Combustion and Loading Environment

DTIC Science & Technology

2009-03-01

work showed that the material is sensitive in fatigue to center holes above 84% UTS. Barth Boyer did fatigue and creep testing double edge notched...panel obtained for this test was also used in previous AFIT thesis work by Boyer . It is a 12 in x 12 in panel consisting of an eight harness satin...weave with a [0°/90°] fiber orientation. The panel number is 4569-2. The panel properties obtained by Boyer are in Table 3. 17 Table 3

Estimation of the kinetic energy dissipation in fall-arrest system and manikin during fall impact.

PubMed

Wu, John Z; Powers, John R; Harris, James R; Pan, Christopher S

2011-04-01

Fall-arrest systems (FASs) have been widely applied to provide a safe stop during fall incidents for occupational activities. The mechanical interaction and kinetic energy exchange between the human body and the fall-arrest system during fall impact is one of the most important factors in FAS ergonomic design. In the current study, we developed a systematic approach to evaluate the energy dissipated in the energy absorbing lanyard (EAL) and in the harness/manikin during fall impact. The kinematics of the manikin and EAL during the impact were derived using the arrest-force time histories that were measured experimentally. We applied the proposed method to analyse the experimental data of drop tests at heights of 1.83 and 3.35 m. Our preliminary results indicate that approximately 84-92% of the kinetic energy is dissipated in the EAL system and the remainder is dissipated in the harness/manikin during fall impact. The proposed approach would be useful for the ergonomic design and performance evaluation of an FAS. STATEMENT OF RELEVANCE: Mechanical interaction, especially kinetic energy exchange, between the human body and the fall-arrest system during fall impact is one of the most important factors in the ergonomic design of a fall-arrest system. In the current study, we propose an approach to quantify the kinetic energy dissipated in the energy absorbing lanyard and in the harness/body system during fall impact.

Compliant walker

NASA Technical Reports Server (NTRS)

Kerley, James J. (Inventor); Eklund, Wayne D. (Inventor); Crane, J. Allen (Inventor)

1992-01-01

A compliant walker is provided for humans having limited use of their legs and lower back. It includes an upright wheel frame which at least partially surrounds an upright user wearing a partial body harness. It is attached to the frame by means of cable compliant apparatus consisting of sets of cable segments and angle bracket members connected between opposite side members of the frame and adjacent side portions of the harness. Novelty is believed to exist in the combination of a wheeled frame including a side support structure, a body harness, and compliance means connecting the body harness to the side support structure for flexibility holding and supporting a person in a substantially upright position when the user sags in the frame when taking weight off the lower extremities.

Harnessing Next-Generation Sequencing Capabilities for Microbial Forensics

DTIC Science & Technology

2014-07-15

content typing, rep-PCR, pulsed-field gel electrophoresis, optical mapping, and antimicrobial susceptibility testing (G. Gault et al., 2011; P...Tremlett, G, Pidd, 2011). This case demonstrates the vulnerability of our food supply and why unusual outbreaks involving endemic microbes must be taken as... food products to malevolent tampering, and the widespread international economic consequences that can occur even from limited product contamination

Simultaneous Planning and Control for Autonomous Ground Vehicles

DTIC Science & Technology

2009-02-01

these applications is called A * ( A -star), and it was originally developed by Hart, Nilsson, and Raphael [HAR68]. Their research presented the formal...sequence, rather than a dynamic programming approach. A * search is a technique originally developed for Artificial Intelligence 43 applications ... developed at the Center for Intelligent Machines and Robotics, serves as a platform for the implementation and testing discussed. autonomous

STS-64 SAFER Assembly

NASA Image and Video Library

1993-12-10

S93-50137 (December 1993) --- This small mobility-aiding back harness, complemented in extravehicular activity (EVA) with a hand controller unit and called the Simplified Aid for EVA Rescue (SAFER) system, will get extensive in-space evaluation and testing during the STS-64 mission. In this view the SAFER is open to reveal the gas supply and thrusters. SAFER is to fly on STS-76 as well.

Harnessing the Internet for International Exchanges on Learning Cities: The Pie Experience 2011-2013

ERIC Educational Resources Information Center

Kearns, Peter

2014-01-01

The PASCAL International Exchanges (PIE) project was developed to facilitate online exchanges of information and experience between learning cities around the world and, in doing this, to test the potential of the internet to enable such low-cost exchanges. The author provides a personal assessment of the PIE experience over the three years 2011…

Cable Effects Study. Tangents, Rabbit Holes, Dead Ends, and Valuable Results

DOE PAGES

Ardelean, Emil V.; Babuška, Vít; Goodding, James C.; ...

2014-08-04

Lessons learned during a study on the effects that electrical power and signal wiring harness cables introduce on the dynamic response of precision spacecraft is presented, along with the most significant results. Our study was a three year effort to discover a set of practical approaches for updating well-defined dynamic models of harness-free structures where knowledge of the cable type, position, and tie-down method are known. Although cables are found on every satellite, the focus was on precision, low damping, and very flexible structures. Obstacles encountered, classified as tangents, rabbit holes, and dead ends, offer practical lessons for structural dynamicsmore » research. The paper traces the historical, experiential progression of the project, describing how the obstacles affected the project. Methods were developed to estimate cable properties. Problems were encountered because of the flexible, highly damped nature of cables. A beam was used as a test article to validate experimentally derived cable properties and to refine the assumptions regarding boundary conditions. Furthermore, a spacecraft bus-like panel with cables attached was designed, and finite element models were developed and validated through experiment. Various paths were investigated at each stage before a consistent test and analysis methodology was developed« less

Cable Effects Study. Tangents, Rabbit Holes, Dead Ends, and Valuable Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ardelean, Emil V.; Babuška, Vít; Goodding, James C.

Lessons learned during a study on the effects that electrical power and signal wiring harness cables introduce on the dynamic response of precision spacecraft is presented, along with the most significant results. Our study was a three year effort to discover a set of practical approaches for updating well-defined dynamic models of harness-free structures where knowledge of the cable type, position, and tie-down method are known. Although cables are found on every satellite, the focus was on precision, low damping, and very flexible structures. Obstacles encountered, classified as tangents, rabbit holes, and dead ends, offer practical lessons for structural dynamicsmore » research. The paper traces the historical, experiential progression of the project, describing how the obstacles affected the project. Methods were developed to estimate cable properties. Problems were encountered because of the flexible, highly damped nature of cables. A beam was used as a test article to validate experimentally derived cable properties and to refine the assumptions regarding boundary conditions. Furthermore, a spacecraft bus-like panel with cables attached was designed, and finite element models were developed and validated through experiment. Various paths were investigated at each stage before a consistent test and analysis methodology was developed« less

Development of termination and utilization concepts for flat conductor cables. Volume 2: Utilization of small gage wire round conductor cables

NASA Technical Reports Server (NTRS)

1972-01-01

The practical use of small-gage round wire for electrical wiring in manned air and space vehicle environments is discussed. The investigation consisted on a study of wire construction and candidate wire harness concepts, fabrication of small-gage wire harnesses, and verification of promising configurations by laboratory evaluation. The wire constructions selected for harness fabrication are described. Results of the laboratory evaluation are included.

An experimental apparatus to simulate body-powered prosthetic usage: Development and preliminary evaluation.

PubMed

Gao, Fan; Rodriguez, Johanan; Kapp, Susan

2016-06-01

Harness fitting in the body-powered prosthesis remains more art than science due to a lack of consistent and quantitative evaluation. The aim of this study was to develop a mechanical, human-body-shaped apparatus to simulate body-powered upper limb prosthetic usage and evaluate its capability of quantitative examination of harness configuration. The apparatus was built upon a torso of a wooden mannequin and integrated major mechanical joints to simulate terminal device operation. Sensors were used to register cable tension, cable excursion, and grip force simultaneously. The apparatus allowed the scapula to move up to 127 mm laterally and the load cell can measure the cable tension up to 445 N. Our preliminary evaluation highlighted the needs and importance of investigating harness configurations in a systematic and controllable manner. The apparatus allows objective, systematic, and quantitative evaluation of effects of realistic harness configurations and will provide insightful and working knowledge on harness fitting in upper limb amputees using body-powered prosthesis. © The International Society for Prosthetics and Orthotics 2015.

Radiated Susceptibility Test Procedure and Setup Exploiting Crosstalk

NASA Astrophysics Data System (ADS)

Grassi, F.; Pignari, S. A.; Spadacini, G.; Bisognin, P.; Pelissou, P.; Marra, S.

2016-05-01

In this work, basic principles of an alternative test procedure exploiting crosstalk to reproduce in the terminal loads of a wiring structure the same disturbances that would be induced by traditional radiated susceptibility (RS) tests are presented. Equivalence with radiation is achieved by the use of a generator circuit properly fed with two synchronized RF generators, and holds for whatever loads (even not linear) connected to the terminations of the cable harness. The proposed procedure is here tailored to the specific conditions of incidence foreseen by aerospace Standards on RS. Its effectiveness is validated by measurements carried out in an ad hoc test setup.

Status of 30 cm mercury ion thruster development

NASA Technical Reports Server (NTRS)

Sovey, J. S.; King, H. J.

1974-01-01

Two engineering model 30-cm ion thrusters were assembled, calibrated, and qualification tested. This paper discusses the thruster design, performance, and power system. Test results include documentation of thrust losses due to doubly charged mercury ions and beam divergence by both direct thrust measurements and beam probes. Diagnostic vibration tests have led to improved designs of the thruster backplate structure, feed system, and harness. Thruster durability is being demonstrated over a thrust range of 97 to 113 mN at a specific impulse of about 2900 seconds. As of August 15, 1974, the thruster has successfully operated for over 4000 hours.

Engineers test STS-37 CETA electrical hand pedal cart in JSC MAIL Bldg 9A

NASA Technical Reports Server (NTRS)

1990-01-01

McDonnell Douglas engineers Noland Talley (left) and Gary Peters (center) and ILC-Dover engineer Richard Richard Smallcombe prepare test setup for the evaluation of the crew and equipment translation aid (CETA) electrical hand pedal cart in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A. Peters, wearing extravehicular mobility unit (EMU) boots and positioned in portable foot restraint (PFR), is suspended above CETA cart and track via harness to simulate weightlessness. CETA will be tested in orbit in the payload bay of Atlantis, Orbiter Vehicle (OV) 104, during STS-37.

Shoulder harnesses

DOT National Transportation Integrated Search

1979-06-01

This bibliography represents literature acquired since the establishment of the National Highway Traffic Safety Administration (NHTSA) concerning the development and use of shoulder harnesses in motor vehicles. It is comprised of NHTSA contract repor...

Biomechanical analysis of occupant kinematics in rollover motor vehicle accidents: dynamic spit test.

PubMed

Sances, Anthony; Kumaresan, Srirangam; Clarke, Richard; Herbst, Brian; Meyer, Steve

2005-01-01

A better understanding of occupant kinematics in rollover accidents helps to advance biomechanical knowledge and to enhance the safety features of motor vehicles. While many rollover accident simulation studies have adopted the static approach to delineate the occupant kinematics in rollover accidents, very few studies have attempted the dynamic approach. The present work was designed to study the biomechanics of restrained occupants during rollover accidents using the steady-state dynamic spit test and to address the importance of keeping the lap belt fastened. Experimental tests were conducted using an anthropometric 50% Hybrid III dummy in a vehicle. The vehicle was rotated at 180 degrees/second and the dummy was restrained using a standard three-point restraint system. The lap belt of the dummy was fastened either by using the cinching latch plate or by locking the retractor. Three configurations of shoulder belt harness were simulated: shoulder belt loose on chest with cinch plate, shoulder belt under the left arm and shoulder belt behind the chest. In all tests, the dummy stayed within the confinement of the vehicle indicating that the securely fastened lap belt holds the dummy with dynamic movement of 3 1/2" to 4". The results show that occupant movement in rollover accidents is least affected by various shoulder harness positions with a securely fastened lap belt. The present study forms a first step in delineating the biomechanics of occupants in rollover accidents.

Scientific crowdsourcing in wildlife research and conservation: Tigers (Panthera tigris) as a case study.

PubMed

Can, Özgün Emre; D'Cruze, Neil; Balaskas, Margaret; Macdonald, David W

2017-03-01

With around 3,200 tigers (Panthera tigris) left in the wild, the governments of 13 tiger range countries recently declared that there is a need for innovation to aid tiger research and conservation. In response to this call, we created the "Think for Tigers" study to explore whether crowdsourcing has the potential to innovate the way researchers and practitioners monitor tigers in the wild. The study demonstrated that the benefits of crowdsourcing are not restricted only to harnessing the time, labor, and funds from the public but can also be used as a tool to harness creative thinking that can contribute to development of new research tools and approaches. Based on our experience, we make practical recommendations for designing a crowdsourcing initiative as a tool for generating ideas.

CyberKM: Harnessing Dynamic Knowledge for Competitive Advantage through Cyberspace

DTIC Science & Technology

2010-11-01

action (e.g., consider attempting to ride a bicycle , negotiate a contract, or conduct qualitative research based solely upon reading a book about the......interprets the data from signals, develops information through incorporation of meaning and context, and finally develops actionable knowledge

Teachers and Children Inquire into Reggio Emilia

ERIC Educational Resources Information Center

Clyde, Jean Anne; Miller, Carol; Sauer, Stacy; Liebert, Karen; Parker, Susan; Runyan, Sarah

2006-01-01

"Reggio Emilia" is a remarkable, interdisciplinary inquiry-based approach typically found in preschools. What happens when elementary teachers confined by curricular mandates embrace key features of this learner-centered philosophy? This article provides compelling evidence that when multiple literacies are harnessed in support of inquiry, the…

Mobilizing the rhizosphere microbiome to enhance orchard system resilience

USDA-ARS?s Scientific Manuscript database

Soils possess a wealth of biological resources that can be harnessed for use in the optimization of plant performance in agroecosystems. Functional biological control outcomes, beyond those realized based upon introduction of synthetic microbiomes, have been documented in a variety of instances, an...

Lg Attenuation and Site Response in the SiChuan basin and the Bayan Har block before the 2008 Ms8.0 Wenchuan Earthquake

NASA Astrophysics Data System (ADS)

Zhu, X.

2017-12-01

On 12 May, 2008, the Sichuan province in China suffered the catastrophic Wenchuan earthquake (MS 8). Prior to the event, a large number of small to moderate earthquakes occurred in the area were recorded at stations of SiChuan Seismic Network (SCSN). The wave data were collected during the years 2006-2008, The Fourier amplitude spectra of Lg wave are used to determine attenuation and site responses. We analyze over 3300 seismograms for Lg-wave propagation from 291 local and regional earthquakes recorded at distances from 100 to 700 km, the earthquakes varied in ML2.0 and 5.7.A joint inversion method estimating attenuation and site responses from seismic spectral ratios is implemented in the study; modeling errors are determined using a delete-j jackknife resampling technique.Variations of the Lg attenuation in a chronological order are studied. The event occurred on the Longmen Shan Fault (LSF), the LSF constitutes boundary betweeb Bayan Har block and eastern. The data are divided into two subgroups based on the seismic ray paths which contained entirely within the SiChuan basin or the Bayan Har block. The waveforms were processed in a frequency range of 1-7 Hz with an interval of 0.2 Hz. On the vertical component, Lg Attenuation in the Bayan Har block are fit by a frequency-dependent function Q(f)=250.2±13.7f0.52±0.03,the SiChuan basin is characterized by function Q(f)=193±23f0.0.81±0.05. The obtained attenuation curves indicate that the spectral amplitudes decay faster in the SiChuan basin than in the Bayan Har block. Site responses from the 48 stations are estimated, the site responses vary among these stations by more than a factor of 10 within the frequency range of interest.The results from the regrouping of data in chronological order show that when the Whenchuan earthquake is approaching, the changes in attenuation occur significantly, but the changes in site responses do not occur.

Testing an attachment method for solar-powered tracking devices on a long-distance migrating shorebird

USGS Publications Warehouse

Chan, Ying-Chi; Brugge, Martin; Tibbitts, T. Lee; Dekinga, Anne; Porter, Ron; Klaassen, Raymond H. G.; Piersma, Theunis

2016-01-01

Small solar-powered satellite transmitters and GPS data loggers enable continuous, multi-year, and global tracking of birds. What is lacking, however, are reliable methods to attach these tracking devices to small migratory birds so that (1) flight performance is not impacted and (2) tags are retained during periods of substantial mass change associated with long-distance migration. We developed a full-body harness to attach tags to Red Knots (Calidris canutus), a medium-sized shorebird (average mass 124 g) that undertakes long-distance migrations. First, we deployed dummy tags on captive birds and monitored them over a complete migratory fattening cycle (February–July 2013) during which time they gained and lost 31–110 g and underwent a pre-alternate moult of body feathers. Using each individual’s previous year fattening and moult data in captivity as controls, we compared individual mass and moult differences between years between the tagged and reference groups, and concluded that the attachment did not impact mass and moult cycles. However, some birds shed feathers under the tags and under the polyester harness line commonly used in avian harnesses. Feather shedding was alleviated by switching to smoothed-bottom tags and monofilament harness lines. To field-trial this design, we deployed 5-g satellite transmitters on ten Red Knots released on 3 October 2013 in the Dutch Wadden Sea. Bird movements and tag performance appeared normal. However, nine tags stopped transmitting 11–170 days post-release which was earlier than expected. We attribute this to bird mortality rather than failure of the attachments or transmitters and suggest that the extra weight and drag caused by the tag and its feather-blocking shield increased the chance of depredation by the locally common Peregrine Falcons (Falco peregrinus). Our results demonstrate that species- and place-specific contexts can strongly determine tagging success. While captive trials are an important first step in developing an attachment method, field trials are essential to fully assess attachment designs.

KSC-08pd1379

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- In a rescue training exercise, known as Mode VIII, off Florida's central east coast, a participant is lifted out of the water with a harness from an HH-60G helicopter. In support of, and with logistical support from, NASA, USSTRATCOM is hosting a major exercise involving Department of Defense, Department of Homeland Security, search and rescue (SAR) forces, including the 45th Space Wing at Patrick Air Force Base, which support space shuttle astronaut bailout contingency operations, known as Mode VIII. This exercise tests SAR capabilities to locate, recover and provide medical treatment for astronauts following a space shuttle launch phase open-ocean bailout. Participants include members of the U.S. Navy, U.S. Coast Guard, U.S. Air Force, and NASA's Kennedy Space Center and Johnson Space Center. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd1380

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- In a rescue training exercise, known as Mode VIII, off Florida's central east coast, a participant is lifted out of the water with a harness from an HH-60G helicopter. In support of, and with logistical support from, NASA, USSTRATCOM is hosting a major exercise involving Department of Defense, Department of Homeland Security, search and rescue (SAR) forces, including the 45th Space Wing at Patrick Air Force Base, which support space shuttle astronaut bailout contingency operations, known as Mode VIII. This exercise tests SAR capabilities to locate, recover and provide medical treatment for astronauts following a space shuttle launch phase open-ocean bailout. Participants include members of the U.S. Navy, U.S. Coast Guard, U.S. Air Force, and NASA's Kennedy Space Center and Johnson Space Center. Photo credit: NASA/Dimitri Gerondidakis

Web 2.0 Technologies for Effective Knowledge Management in Organizations: A Qualitative Analysis

ERIC Educational Resources Information Center

Nath, Anupam Kumar

2012-01-01

A new generation of Internet-based collaborative tools, commonly known as Web 2.0, has increased in popularity, availability, and power in the last few years (Kane and Fichman, 2009). Web 2.0 is a set of Internet-based applications that harness network effects by facilitating collaborative and participative computing (O'Reilly, 2006).…

Cushion System for Multi-Use Child Safety Seat

NASA Technical Reports Server (NTRS)

Dabney, Richard W. (Inventor); Elrod, Susan V. (Inventor)

2007-01-01

A cushion system for use with a child safety seat has a plurality of bladders assembled to form a seat cushion that cooperates with the seat's safety harness. One or more sensors coupled to the safety harness sense tension therein and generate a signal indicative of the tension. Each of the bladders is individually pressurized by a pressurization system to define a support configuration of the seat cushion. The pressurization system is disabled when tension in the safety harness has attained a threshold level.

Cushion system for multi-use child safety seat

NASA Technical Reports Server (NTRS)

Elrod, Susan V. (Inventor); Dabney, Richard W. (Inventor)

2007-01-01

A cushion system for use with a child safety seat has a plurality of bladders assembled to form a seat cushion that cooperates with the seat's safety harness. One or more sensors coupled to the safety harness sense tension therein and generate a signal indicative of the tension. Each of the bladders is individually pressurized by a pressurization system to define a support configuration of the seat cushion. The pressurization system is disabled when tension in the safety harness has attained a threshold level.

Harnessing vision for computation.

PubMed

Changizi, Mark

2008-01-01

Might it be possible to harness the visual system to carry out artificial computations, somewhat akin to how DNA has been harnessed to carry out computation? I provide the beginnings of a research programme attempting to do this. In particular, new techniques are described for building 'visual circuits' (or 'visual software') using wire, NOT, OR, and AND gates in a visual 6modality such that our visual system acts as 'visual hardware' computing the circuit, and generating a resultant perception which is the output.

Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.

PubMed

Boccardi, Marina; Bocchetta, Martina; Morency, Félix C; Collins, D Louis; Nishikawa, Masami; Ganzola, Rossana; Grothe, Michel J; Wolf, Dominik; Redolfi, Alberto; Pievani, Michela; Antelmi, Luigi; Fellgiebel, Andreas; Matsuda, Hiroshi; Teipel, Stefan; Duchesne, Simon; Jack, Clifford R; Frisoni, Giovanni B

2015-02-01

The European Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard of truth to train new tracers, and to validate automated segmentation algorithms. Training requires large and representative data sets of segmented hippocampi. This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms. Sixty-eight 1.5 T and 67 3 T volumetric structural ADNI scans from different subjects, balanced by age, medial temporal atrophy, and scanner manufacturer, were segmented by five qualified HarP tracers whose absolute interrater intraclass correlation coefficients were 0.953 and 0.975 (left and right). Labels were validated as HarP compliant through centralized quality check and correction. Hippocampal volumes (mm(3)) were as follows: controls: left = 3060 (standard deviation [SD], 502), right = 3120 (SD, 897); mild cognitive impairment (MCI): left = 2596 (SD, 447), right = 2686 (SD, 473); and Alzheimer's disease (AD): left = 2301 (SD, 492), right = 2445 (SD, 525). Volumes significantly correlated with atrophy severity at Scheltens' scale (Spearman's ρ = <-0.468, P = <.0005). Cerebrospinal fluid spaces (mm(3)) were as follows: controls: left = 23 (32), right = 25 (25); MCI: left = 15 (13), right = 22 (16); and AD: left = 11 (13), right = 20 (25). Five subjects (3.7%) presented with unusual anatomy. This work provides reference hippocampal labels for the training and certification of automated segmentation algorithms. The publicly released labels will allow the widespread implementation of the standard segmentation protocol. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

High-throughput genotyping-by-sequencing facilitates molecular tagging of a novel rust resistance gene, R 15 , in sunflower (Helianthus annuus L.).

PubMed

Ma, G J; Song, Q J; Markell, S G; Qi, L L

2018-07-01

A novel rust resistance gene, R 15 , derived from the cultivated sunflower HA-R8 was assigned to linkage group 8 of the sunflower genome using a genotyping-by-sequencing approach. SNP markers closely linked to R 15 were identified, facilitating marker-assisted selection of resistance genes. The rust virulence gene is co-evolving with the resistance gene in sunflower, leading to the emergence of new physiologic pathotypes. This presents a continuous threat to the sunflower crop necessitating the development of resistant sunflower hybrids providing a more efficient, durable, and environmentally friendly host plant resistance. The inbred line HA-R8 carries a gene conferring resistance to all known races of the rust pathogen in North America and can be used as a broad-spectrum resistance resource. Based on phenotypic assessments of 140 F 2 individuals derived from a cross of HA 89 with HA-R8, rust resistance in the population was found to be conferred by a single dominant gene (R 15 ) originating from HA-R8. Genotypic analysis with the currently available SSR markers failed to find any association between rust resistance and any markers. Therefore, we used genotyping-by-sequencing (GBS) analysis to achieve better genomic coverage. The GBS data showed that R 15 was located at the top end of linkage group (LG) 8. Saturation with 71 previously mapped SNP markers selected within this region further showed that it was located in a resistance gene cluster on LG8, and mapped to a 1.0-cM region between three co-segregating SNP makers SFW01920, SFW00128, and SFW05824 as well as the NSA_008457 SNP marker. These closely linked markers will facilitate marker-assisted selection and breeding in sunflower.

Geographic delineations of yeast communities and populations associated with vines and wines in New Zealand

PubMed Central

Gayevskiy, Velimir; Goddard, Matthew R

2012-01-01

Yeasts are a diverse seemingly ubiquitous group of eukaryotic microbes, and many are naturally associated with fruits. Humans have harnessed yeasts since the dawn of civilisation to make wine, and thus it is surprising that we know little of the distribution of yeast communities naturally associated with fruits. Previous reports of yeast community diversity have been descriptive only. Here we present, we believe, the first robust test for the geographic delineation of yeast communities. Humans have relatively recently employed Saccharomyces cerevisiae as a model research organism, and have long harnessed its ancient adaption to ferment even in the presence of oxygen. However, as far as we are aware, there has not been a rigorous test for the presence of regional differences in natural S. cerevisiae populations before. We combined these community- and population-level questions and surveyed replicate vineyards and corresponding spontaneous ferments from different regions on New Zealand's (NZ's) North Island and analysed the resulting data with community ecology and population genetic tests. We show that there are distinct regional delineations of yeast communities, but the picture for S. cerevisiae is more complex: there is evidence for region-specific sub-populations but there are also reasonable levels of gene flow among these regions in NZ. We believe this is the first demonstration of regional delineations of yeast populations and communities worldwide. PMID:22189497

Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium

PubMed Central

Loh, Po-Ru; Lipson, Mark; Patterson, Nick; Moorjani, Priya; Pickrell, Joseph K.; Reich, David; Berger, Bonnie

2013-01-01

Long-range migrations and the resulting admixtures between populations have been important forces shaping human genetic diversity. Most existing methods for detecting and reconstructing historical admixture events are based on allele frequency divergences or patterns of ancestry segments in chromosomes of admixed individuals. An emerging new approach harnesses the exponential decay of admixture-induced linkage disequilibrium (LD) as a function of genetic distance. Here, we comprehensively develop LD-based inference into a versatile tool for investigating admixture. We present a new weighted LD statistic that can be used to infer mixture proportions as well as dates with fewer constraints on reference populations than previous methods. We define an LD-based three-population test for admixture and identify scenarios in which it can detect admixture events that previous formal tests cannot. We further show that we can uncover phylogenetic relationships among populations by comparing weighted LD curves obtained using a suite of references. Finally, we describe several improvements to the computation and fitting of weighted LD curves that greatly increase the robustness and speed of the calculations. We implement all of these advances in a software package, ALDER, which we validate in simulations and apply to test for admixture among all populations from the Human Genome Diversity Project (HGDP), highlighting insights into the admixture history of Central African Pygmies, Sardinians, and Japanese. PMID:23410830

Improving highway advisory radio predictability and performance

DOT National Transportation Integrated Search

2011-01-01

Highway Advisory Radio (HAR) stations, sometimes referred to as Travelers Information Stations (TIS), : allow highway agencies to broadcast important messages about traffic, weather and roadway conditions to : motorists. Caltrans has deployed HAR ...

42 CFR 84.201 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of pressure over the entire area in contact with the face. (2) Facepieces for single-use vinyl... face. (b) Mouthpieces shall be equipped where applicable, with an adjustable and replaceable harness...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2010 CFR

2010-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2013 CFR

2013-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2014 CFR

2014-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2011 CFR

2011-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.521 - Shoulder harness.

Code of Federal Regulations, 2012 CFR

2012-01-01

... inertia load factors established under the certification basis of the airplane. (b) No person may operate... used; and (2) Safety belt and shoulder harness restraint systems may be designed to the inertia load...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

14 CFR 91.1035 - Passenger awareness.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Use of safety belts, shoulder harnesses, and child restraint systems: Each passenger must be briefed... installed, his or her shoulder harness fastened about him or her, and if a child is being transported, the...

Human Activity Recognition Supported on Indoor Localization: A Systematic Review.

PubMed

Cerón, Jesús; López, Diego M

2018-01-01

The number of older adults is growing worldwide. This has a social and economic impact in all countries because of the increased number of older adults affected by chronic diseases, health emergencies, and disabilities, representing at the end high cost for the health system. To face this problem, the Ambient Assisted Living (AAL) domain has emerged. Its main objective is to extend the time that older adults can live independently in their homes. AAL is supported by different fields and technologies, being Human Activity Recognition (HAR), control of vital signs and location tracking the three of most interest during the last years. To perform a systematic review about Human Activity Recognition (HAR) approaches supported on Indoor Localization (IL) and vice versa, describing the methods they have used, the accuracy they have obtained and whether they have been directed towards the AAL domain or not. A systematic review of six databases was carried out (ACM, IEEE Xplore, PubMed, Science Direct and Springer). 27 papers were found. They were categorised into three groups according their approach: paper focus on 1. HAR, 2. IL, 3. HAR and IL. A detailed analysis of the following factors was performed: type of methods and technologies used for HAR, IL and data fusion, as well as the precision obtained for them. This systematic review shows that the relationship between HAR and IL has been very little studied, therefore providing insights of its potential mutual support to provide AAL solutions.

Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig.

PubMed

Moroni, Maria; Elliott, Thomas B; Deutz, Nicolaas E; Olsen, Cara H; Owens, Rossitsa; Christensen, Christine; Lombardini, Eric D; Whitnall, Mark H

2014-05-01

To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal (GI-ARS) syndrome. Male minipigs, approximately 5 months old, 9-12 kg in weight, were irradiated with Cobalt-60 (total body, bilateral gamma irradiation, 0.6 Gy/min). Endpoints were 10-day survival, gastrointestinal histology, plasma citrulline, bacterial translocation, vomiting, diarrhea, vital signs, systemic inflammatory response syndrome (SIRS), febrile neutropenia (FN). We exposed animals to doses (2.2-5.0 Gy) above those causing H-ARS (1.6-2.0 Gy), and evaluated development of ARS. Compared to what was observed during H-ARS (historical data: Moroni et al. 2011a , 2011c ), doses above 2 Gy produced signs of increasingly severe pulmonary damage, faster deterioration of clinical conditions, and faster increases in levels of C-reactive protein (CRP). In the range of 4.6-5.0 Gy, animals died by day 9-10; signs of the classic GI syndrome, as measured by diarrhea, vomiting and bacterial translocation, did not occur. At doses above 2 Gy we observed transient reduction in circulating citrulline levels, and animals exhibited earlier depletion of blood elements and faster onset of SIRS and FN. An accelerated hematopoietic subsyndrome (AH-ARS) is observed at radiation doses between those producing H-ARS and GI-ARS. It is characterized by early onset of SIRS and FN, and greater lung damage, compared to H-ARS.

Experimental Study and Optimization of Thermoelectricity-Driven Autonomous Sensors for the Chimney of a Biomass Power Plant

NASA Astrophysics Data System (ADS)

Rodríguez, A.; Astrain, D.; Martínez, A.; Aranguren, P.

2014-06-01

In the work discussed in this paper a thermoelectric generator was developed to harness waste heat from the exhaust gas of a boiler in a biomass power plant and thus generate electric power to operate a flowmeter installed in the chimney, to make it autonomous. The main objective was to conduct an experimental study to optimize a previous design obtained after computational work based on a simulation model for thermoelectric generators. First, several places inside and outside the chimney were considered as sites for the thermoelectricity-driven autonomous sensor. Second, the thermoelectric generator was built and tested to assess the effect of the cold-side heat exchanger on the electric power, power consumption by the flowmeter, and transmission frequency. These tests provided the best configuration for the heat exchanger, which met the transmission requirements for different working conditions. The final design is able to transmit every second and requires neither batteries nor electric wires. It is a promising application in the field of thermoelectric generation.

Poly(vinylidene fluoride-hexafluoropropylene) polymer electrolyte for paper-based and flexible battery applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aliahmad, Nojan; Shrestha, Sudhir; Varahramyan, Kody

2016-06-15

Paper-based batteries represent a new frontier in battery technology. However, low-flexibility and poor ionic conductivity of solid electrolytes have been major impediments in achieving practical mechanically flexible batteries. This work discuss new highly ionic conductive polymer gel electrolytes for paper-based battery applications. In this paper, we present a poly(vinylidene fluoride-hexafluoropropylene) (PVDH-HFP) porous membrane electrolyte enhanced with lithium bis(trifluoromethane sulphone)imide (LiTFSI) and lithium aluminum titanium phosphate (LATP), with an ionic conductivity of 2.1 × 10{sup −3} S cm{sup −1}. Combining ceramic (LATP) with the gel structure of PVDF-HFP and LiTFSI ionic liquid harnesses benefits of ceramic and gel electrolytes in providingmore » flexible electrolytes with a high ionic conductivity. In a flexibility test experiment, bending the polymer electrolyte at 90° for 20 times resulted in 14% decrease in ionic conductivity. Efforts to further improving the flexibility of the presented electrolyte are ongoing. Using this electrolyte, full-cell batteries with lithium titanium oxide (LTO) and lithium cobalt oxide (LCO) electrodes and (i) standard metallic current collectors and (ii) paper-based current collectors were fabricated and tested. The achieved specific capacities were (i) 123 mAh g{sup −1} for standard metallic current collectors and (ii) 99.5 mAh g{sup −1} for paper-based current collectors. Thus, the presented electrolyte has potential to become a viable candidate in paper-based and flexible battery applications. Fabrication methods, experimental procedures, and test results for the polymer gel electrolyte and batteries are presented and discussed.« less

Poly(vinylidene fluoride-hexafluoropropylene) polymer electrolyte for paper-based and flexible battery applications

NASA Astrophysics Data System (ADS)

Aliahmad, Nojan; Shrestha, Sudhir; Varahramyan, Kody; Agarwal, Mangilal

2016-06-01

Paper-based batteries represent a new frontier in battery technology. However, low-flexibility and poor ionic conductivity of solid electrolytes have been major impediments in achieving practical mechanically flexible batteries. This work discuss new highly ionic conductive polymer gel electrolytes for paper-based battery applications. In this paper, we present a poly(vinylidene fluoride-hexafluoropropylene) (PVDH-HFP) porous membrane electrolyte enhanced with lithium bis(trifluoromethane sulphone)imide (LiTFSI) and lithium aluminum titanium phosphate (LATP), with an ionic conductivity of 2.1 × 10-3 S cm-1. Combining ceramic (LATP) with the gel structure of PVDF-HFP and LiTFSI ionic liquid harnesses benefits of ceramic and gel electrolytes in providing flexible electrolytes with a high ionic conductivity. In a flexibility test experiment, bending the polymer electrolyte at 90° for 20 times resulted in 14% decrease in ionic conductivity. Efforts to further improving the flexibility of the presented electrolyte are ongoing. Using this electrolyte, full-cell batteries with lithium titanium oxide (LTO) and lithium cobalt oxide (LCO) electrodes and (i) standard metallic current collectors and (ii) paper-based current collectors were fabricated and tested. The achieved specific capacities were (i) 123 mAh g-1 for standard metallic current collectors and (ii) 99.5 mAh g-1 for paper-based current collectors. Thus, the presented electrolyte has potential to become a viable candidate in paper-based and flexible battery applications. Fabrication methods, experimental procedures, and test results for the polymer gel electrolyte and batteries are presented and discussed.

Evidence-based review of clinical outcomes of guideline-recommended pharmacotherapies for generalized anxiety disorder.

PubMed

Bereza, Basil G; Machado, Márcio; Ravindran, Arun V; Einarson, Thomas R

2012-08-01

To quantify the rates of clinical outcomes of Canadian Psychiatric Association (CPA) guideline-recommended pharmacotherapies for generalized anxiety disorder (GAD) by drug classification within each treatment line. Evidence from original research cited by the CPA was included. Pooled analyses, duplicates, and studies with nonextractable data were excluded. Response, remission, and baseline-endpoint or mean reductions scores of the Hamilton Anxiety Rating Scale (HARS) were extracted. The Cochrane Collaboration's computer program, Review Manager, version 5, with a random effects model, was used to pool results. A total of 50 articles were cited as evidence for managing GAD by the CPA. There was sufficient evidence of remission with first- or third-line agents to pool reported rates, and with agents from all 3 treatment lines to pool response rates and reduction in HARS scores. The mean range of effect size varied considerably from study to study within each treatment line. Comparison of pooled remission rates between first- and second-line agents was not possible. While the range of values by drug and drug class overlapped, the summary results for the probability of response and reduction in HARS scores was greater for first-line, compared with second-line, treatments. Drug components for third-line treatments were heterogeneous and produced mixed results. Despite the abundance of evidence in its totality presented in the CPA guidelines, there is inadequate evidence to formulate recommendations based on the pooled results from this study alone. However, such analysis provides an additional resource for clinicians to make more effective treatment decisions for individual patients with GAD.

NASA Standard Initiator Susceptibility to UHF and S-Band Radio Frequency Power and Lightning Strikes

NASA Technical Reports Server (NTRS)

Burnham, Karen; Scully, Robert; Norgard, John

2013-01-01

The NASA Standard Initiator (NSI) is an important piece of pyrotechnic equipment used in many space applications. This presentation will outline the results of a series of tests done at UHF and S-Band frequencies to determine NSI susceptibility to Radio Frequency (RF) power. The results show significant susceptibility to pulsed RF power in the S-Band region. Additional testing with lightning pulses injected into the firing line harness, modelling the indirect effects of a lightning strike to a spacecraft, showed no vulnerability

NASA Standard Initiator Susceptibility to UHF and S-Band Radio Frequency Power and Lightning Strikes

NASA Technical Reports Server (NTRS)

Burnham, Karen; Scully, Robert C.; Norgard, John D.

2013-01-01

The NASA Standard Initiator (NSI) is an important piece of pyrotechnic equipment used in many space applications. This paper outlines the results of a series of tests done at UHF and S-Band frequencies to determine NSI susceptibility to Radio Frequency (RF) power. The results show significant susceptibility to pulsed RF power in the S-Band region. Additional testing with lightning pulses injected into the firing line harness, modelling the indirect effects of a lightning strike to a spacecraft, showed no vulnerability.

Feasibility study of a 270V dc flat cable aircraft electrical power distributed system

NASA Astrophysics Data System (ADS)

Musga, M. J.; Rinehart, R. J.

1982-01-01

This report documents the efforts of a one man-year feasibility study to evaluate the usage of flat conductors in place of conventional round wires for a 270 volt direct current aircraft power distribution system. This study consisted of designing electrically equivalent power distribution harnesses in flat conductor configurations for a currently operational military aircraft. Harness designs were established for installation in aircraft airframes which are: (1) All metal, or (2) All composite, or (3) a mixture of both. Flat cables have greater surface areas for heat transfer allowing higher current densities and therefore lighter weight conductors, than with round wires. Flat cables are less susceptible to electromagnetic effects. However, these positive factors are partially offset by installation and maintenance difficulties. This study concludes that the extent of these difficulties can be adequately limited with appropriate modification to present installation and maintenance practices. A comparative analysis of the flat and the round conductor power distribution harnesses was made for weight, cost, maintenance and reliability. The knowledge gained from the design and comparative analysis phases was used to generate design criteria for flat power cable harnesses and to identify and prioritize flat cable harness components and associated production tooling which require development.

Highway Advisory Radio Message Development Guide, Final Report

DOT National Transportation Integrated Search

1982-10-01

HIGHWAY ADVISORY RADIO (HAR) PROVIDES TRAFFIC OPERATING AGENCIES WITH THE CAPABILITY TO COMMUNICATE TRAFFIC AND TRAVEL RELATED INFORMATION TO MOTORISTS USING THE VEHICLE'S AM RADIO RECEIVER. THIS REPORT PRESENTS RECOMMENDED HAR MESSAGE DEVELOPMENT PR...

HARNESS END OF ELECTRIC TURBINE IN LOWER LEVEL OF HYDROELECTRIC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HARNESS END OF ELECTRIC TURBINE IN LOWER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

Subject Load-Harness Interaction During Zero-Gravity Treadmill Exercise

NASA Technical Reports Server (NTRS)

McCrory, Jean L.; Baron, Heidi A.; Derr, Janice A.; Davis, Brian L.; Cavanagh, Peter R.

1996-01-01

When astronauts exercise on orbit, a subject load device (SLD) must be used to return the subject back to the supporting surface. The load in the SLD needs to be transferred the body by a harness which typically distributes this load between the pelvis and We shoulders. Through the use of a zero-gravity simulator, this research compared subject comfort and ground reaction forces during treadmill running at three levels of subject load (60%,80%, and 100% of body weight) in two harness designs ("shoulder only" and "waist "and shoulder ").

Flat conductor cable design, manufacture, and installation

NASA Technical Reports Server (NTRS)

Angele, W.; Hankins, J. D.

1973-01-01

Pertinent information for hardware selection, design, manufacture, and quality control necessary for flat conductor cable interconnecting harness application is presented. Comparisons are made between round wire cable and flat conductor cable. The flat conductor cable interconnecting harness systems show major cost, weight, and space savings, plus increased system performance and reliability. The design application section includes electrical characteristics, harness design and development, and a full treatise on EMC considerations. Manufacturing and quality control sections pertain primarily to the developed conductor-contact connector system and special flat conductor cable to round wire cable transitions.

Harnessing the Power of Film in the Primary Classroom

ERIC Educational Resources Information Center

Watts, Rowena

2007-01-01

This paper explores one way that teachers can develop creativity within potentially limiting confines and pressures of curriculum guidelines. The researcher considers the inclusion of film as a creative, engaging and effective strategy for teaching reading using data from a small-scale research project. Hypotheses are based on analysis of…

Governmentality of Youth: Managing Risky Subjects

ERIC Educational Resources Information Center

Besley, Tina A. C.

2010-01-01

This article poses the question: How do understandings of governmentality play out in discourses of youth? In the twenty-first-century neoliberal contexts of consumer capitalist societies, discourses of youth need now to move beyond the valuable earlier understandings based on psychological and cultural/subcultural studies to harness Foucault's…

Developing Games and Simulations for Today and Tomorrow's Tech Savvy Youth

ERIC Educational Resources Information Center

Klopfer, Eric; Yoon, Susan

2005-01-01

Constructively promoting the educational development of today's young tech savvy students and fostering the productive technological facility of tomorrow's youth requires harnessing new technological tools creatively. The MIT Teacher Education Program (TEP) focuses on the research and development of educational computer-based simulations and games…

Harnessing High-Throughput Monitoring Methods to Strengthen 21st Century Risk-Based Evaluations (SETAC Presentation)

EPA Science Inventory

Over the past ten years, the US government has invested in high-throughput (HT) methods to screen chemicals for biological activity. Under the interagency Tox21 consortium and the US Environmental Protection Agency’s (EPA) ToxCast™ program, thousands of chemicals have...

Coaching Leadership: Building Educational Leadership Capacity through Partnership. Second Edition

ERIC Educational Resources Information Center

Robertson, Jan

2016-01-01

"Coaching Leadership" is about building leadership capacity in individuals, and in institutions, through enhancing professional relationships. It is based on the importance of maximising potential, and harnessing the ongoing commitment and energy needed to meet personal and professional goals. This book is for anyone interested in…

Seasonal inhalant insect allergy: Harmonia axyridis ladybug.

PubMed

Goetz, David W

2009-08-01

The exotic Asian lady beetle, Harmonia axyridis, has become a prominent cause of seasonal inhalant allergy (allergic rhinitis, asthma, and urticaria) in the last two decades in North America and Europe after being introduced into the environment as an agricultural pest-control predator. Seeking winter hibernation sites, ladybug swarms will invade human habitats in the fall. Large fall swarms and smaller spring dispersions produce corresponding peaks in ladybug allergy. Ladybug allergy prevalence in endemic areas has been reported as high as 10%. For some individuals ladybug allergy is their first expression of allergic disease. Exposures at home, work, school, and in other settings may be sensitizing. Ladybug hemolymph is the primary source of allergens. Har a 1 and Har a 2 major ladybug allergens have been characterized. 'Reflex bleeding' from tibiofemoral joints (for communication and during alarm) disperses these allergens. Ladybug skin testing should be routine in endemic areas. Avoidance continues to be the first step in treatment. Allergen vaccine therapy may be effective, but a commercial extract of H. axyridis is needed.

Locomotion in simulated microgravity: gravity replacement loads

NASA Technical Reports Server (NTRS)

McCrory, Jean L.; Baron, Heidi A.; Balkin, Sandy; Cavanagh, Peter R.

2002-01-01

BACKGROUND: When an astronaut walks or runs on a treadmill in microgravity, a subject load device (SLD) is used to return him or her back to the treadmill belt. The gravity replacement load (GRL) in the SLD is transferred, via a harness, to the pelvis and/or the shoulders. This research compared comfort and ground reaction forces during treadmill running in a microgravity locomotion simulator at GRLs of 60%, 80%, and 100% of body weight (BW). Two harness designs (shoulder springs only (SSO) and waist and shoulder springs (WSS)) were used. HYPOTHESES: 1) The 100% BW gravity replacement load conditions would be comfortably tolerated and would result in larger ground reaction forces and loading rates than the lower load conditions, and 2) the WSS harness would be more comfortable than the SSO harness. METHODS: Using the Penn State Zero Gravity Locomotion Simulator (ZLS), 8 subjects ran at 2.0 m x s(-1) (4.5 mph) for 3 min at each GRL setting in each harness. Subjective ratings of harness comfort, ground reaction forces, and GRL data were collected during the final minute of exercise. RESULTS: The 100% BW loading conditions were comfortably tolerated (2.3 on a scale of 0-10), although discomfort increased as the GRL increased. There were no overall differences in perceived comfort between the two harnesses. The loading rates (27.1, 33.8, 39.1 BW x s(-1)) and the magnitudes of the first (1.0, 1.4, 1.6 BW) and second (1.3, 1.7, 1.9 BW) peaks of the ground reaction force increased with increasing levels (60, 80, 100% BW respectively) of GRL. CONCLUSIONS: Subjects were able to tolerate a GRL of 100% BW well. The magnitude of the ground reaction force peaks and the loading rate is directly related to the magnitude of the GRL.

Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans.

PubMed

Soppe, Jasper Adriaan; Lebbink, Robert Jan

2017-10-01

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune systems. In prokaryotes, small RNA molecules guide Cas effector endonucleases to invading foreign genetic elements in a sequence-dependent manner, resulting in DNA cleavage by the endonuclease upon target binding. A rewired CRISPR/Cas9 system can be used for targeted and precise genome editing in eukaryotic cells. CRISPR/Cas has also been harnessed to target human pathogenic viruses as a potential new antiviral strategy. Here, we review recent CRISPR/Cas9-based approaches to combat specific human viruses in humans and discuss challenges that need to be overcome before CRISPR/Cas9 may be used in the clinic as an antiviral strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

Scientific crowdsourcing in wildlife research and conservation: Tigers (Panthera tigris) as a case study

PubMed Central

Can, Özgün Emre; D’Cruze, Neil; Balaskas, Margaret; Macdonald, David W.

2017-01-01

With around 3,200 tigers (Panthera tigris) left in the wild, the governments of 13 tiger range countries recently declared that there is a need for innovation to aid tiger research and conservation. In response to this call, we created the “Think for Tigers” study to explore whether crowdsourcing has the potential to innovate the way researchers and practitioners monitor tigers in the wild. The study demonstrated that the benefits of crowdsourcing are not restricted only to harnessing the time, labor, and funds from the public but can also be used as a tool to harness creative thinking that can contribute to development of new research tools and approaches. Based on our experience, we make practical recommendations for designing a crowdsourcing initiative as a tool for generating ideas. PMID:28328924

Zero-g simulation system for therapeutic application

NASA Technical Reports Server (NTRS)

Dane, D. H.

1971-01-01

System aids in therapeutic retraining of damaged muscles or functions as walking support during therapy. Articulated harness assembly contains patient, suspension system supports harness assembly in such a way as to counterbalance exertion of external forces on patient.

Summary of the CTS Transient Event Counter data after one year of operation. [Communication Technology Satellite

NASA Technical Reports Server (NTRS)

Stevens, N. J.; Klinect, V. W.; Gore, J. V.

1977-01-01

The environmental charging of satellite surfaces during geomagnetic substorms is the apparent cause of a significant number of anomalous events occurring on geosynchronous satellites since the early 1970's. Electromagnetic pulses produced in connection with the differential charging of insulators can couple into the spacecraft harness and cause electronic switching anomalies. An investigation conducted to determine the response of the spacecraft surfaces to substorm particle fluxes makes use of a harness transient detector. The harness transient detector, called the Transient Event Counter (TEC) was built and integrated into the Canadian-American Communications Technology Satellite (CTS). A description of the TEC and its operational characteristics is given and the obtained data are discussed. The data show that the satellite surfaces appear to be charged to the point that discharges occur and that the discharge-induced transients couple into the wire harnesses.

Simulated weightlessness - Effects on bioenergetic balance

NASA Technical Reports Server (NTRS)

Jordan, J. P.; Sykes, H. A.; Crownover, J. C.; Schatte, C. L.; Simmons, J. B., II; Jordan, D. P.

1980-01-01

As a prelude to a flight experiment, an attempt was made to separate energy requirements associated with gravity from all other metabolic needs. The biological effects of weightlessness were simulated by suspending animals in a harness so that antigravity muscles were not supporting the body. Twelve pairs of rats were allowed to adapt to wearing a harness for 5 d. Experimental animals were then suspended in harness for 7 d followed by recovery for 7 d. Control animals were harnessed but never suspended. Oxygen consumption, carbon dioxide production and rate of (C-14)O2 expiration from radio-labeled glucose were monitored on selected days. Food intake and body mass were recorded daily. Metabolic rate decreased in experimental animals during 7 d of suspension and returned to normal during recovery. Although some of the metabolic changes may have related to variation in food intake, simulated weightlessness appears to directly affect bioenergetic balance.

Safety harness

DOEpatents

Gunter, Larry W.

1993-01-01

A safety harness to be worn by a worker, especially a worker wearing a plastic suit thereunder for protection in a radioactive or chemically hostile environment, which safety harness comprises a torso surrounding portion with at least one horizontal strap for adjustably securing the harness about the torso, two vertical shoulder straps with rings just forward of the of the peak of the shoulders for attaching a life-line and a pair of adjustable leg supporting straps releasibly attachable to the torso surrounding portion. In the event of a fall, the weight of the worker, when his fall is broken and he is suspended from the rings with his body angled slightly back and chest up, will be borne by the portion of the leg straps behind his buttocks rather than between his legs. Furthermore, the supporting straps do not restrict the air supplied through hoses into his suit when so suspended.

Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

NASA Technical Reports Server (NTRS)

Stevens, N. J.; Levell, R. R.; Klinect, V. W.

1976-01-01

The transient event counter (TEC), senses and counts transients having a voltage rise of greater than five volts in three separate wire harnesses: the attitude control harness, the solar array instrumentation harness and the solar array power harness. The operational characteristics of TEC are defined and the preliminary results obtained through the first 90 days of operation including the spring 1976 eclipse season are presented. The results show that the Communications Technology Satellite was charged to the point where discharges occurred. The discharge induced transients did not cause any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the one second sample interval are greater than anticipated. The compilation and review of the data is continuing.

Earth Observations taken by the Expedition 13 crew

NASA Image and Video Library

2006-09-07

ISS013-E-78506 (7 Sept. 2006) --- Sand dunes near Mongolia's Har Lake are featured in this image photographed by an Expedition 13 crewmember on the International Space Station. Har (or Black) Lake is located in the western part of the country within the Valley of Lakes--part of a system of closed basins that stretches across central Asia. According to scientists, these basins are the remnants of larger paleolakes that had begun to shrink in size by approximately five thousand years ago as regional climate became drier. Today, the Valley of Lakes is an important ecological resource for study of steppe grasslands, and as resting points for large numbers of migratory birds. Portions of the basin are designated as national parks or other protected areas, and Har Lake itself is an ecotourism destination (usually by horseback). This oblique view captures the dynamic nature of the landscape of Har Lake. The lake is encircled by sand dune fields which encroach on the lower slopes of the Tobhata Mountains to the west and south. Gaps in the mountains have been exploited by sand dunes moving eastward (indicating westerly winds) -- the most striking example being a series of dunes entering Har Lake along its southwestern shoreline. Here, the dune forms reflect the channeling of winds through the break in the mountain ridgeline, leading to dune crests oriented transverse to northwesterly winds. Another well-developed line of dunes is visible between Har and Baga Lakes. While these dunes appear to cut across a lake surface, the dunes have in fact moved across a narrow stream channel.

CRASHWORTHY TROOP SEAT INVESTIGATION

DTIC Science & Technology

1974-12-01

helicopter structure and landing gear. Newly de - signed helicopters will have landing gear designed to with- stand high sink rates and structure whioh provides...when there is no ___ ditb i- the-restrant s tystem s p§’-Hardware components sAiall carry the restraint harness design loads without permanent de ...Specification can be accepted, a troop seat design must be tested to demonstrate compliance with the proposed draft General Military Specification. Such

Dynamic Testing and Automatic Repair of Reconfigurable Wiring Harnesses

DTIC Science & Technology

2006-11-27

Switch An M ×N grid of switches configured to provide a M -input, N -output routing network. Permutation Network A permutation network performs an...wiring reduces the effective advantage of their reduced switch count, particularly when considering that regular grids (crossbar switches being a...are connected to. The outline circuit shown in Fig. 20 shows how a suitable ‘discovery probe’ might be implemented. The circuit shows a UART

Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

DTIC Science & Technology

2016-10-01

scheduled plus 33 to be enrolled, because we assume that the proportion of withdrawals will be the same as experienced to date, i.e., 24%. This plan will...period? Victor Mark, Investigator Interactive Immersive Virtual Reality Walking for SCI Neuropathic Pain (Trost) 0.24 calendar months Kim Cerise...Direct Costs: $149,999 This project designs and test an immersive virtual reality treatment method to control neuropathic pain following traumatic spinal

Harnessing Energy from the Sun for Six Billion People

ScienceCinema

Nocera, Daniel

2018-05-24

Daniel Nocera, a Massachusetts Institute of Technology professor whose recent research focuses on solar-powered fuels, presents a Brookhaven Science Associates Distinguished Lecture, titled "Harnessing Energy from the Sun for Six Billion People -- One at a Time."

Harnessing Power from Tides: State of the Art.

ERIC Educational Resources Information Center

Ryan, Paul R.

1979-01-01

Discussed is the current, world-wide status of tidal energy as a potential power source. Potential sites and global tidal power prospects are identified. New engineering concepts relevant to the harnessing of tidal power are identified and described. (BT)

77 FR 21100 - Change in Bank Control Notices; Formations of, Acquisitions by, and Mergers of Bank Holding...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-09

... Nichols, Washington, DC; to acquire voting shares of HarVest Bancorp, Inc., Gaithersburg, Maryland, and thereby indirectly acquire voting shares of HarVest Bank of Maryland, Rockville, Maryland. Comments on...

Harnessing solar pressure to slew and point large infrared space telescopes

NASA Astrophysics Data System (ADS)

Errico, Simona; Angel, Roger P.; Calvert, Paul D.; Woof, Neville

2003-03-01

Large astronomical Gossamer telescopes in space will need to employ large solar shields to safeguard the optics from solar radiation. These types of telescopes demand accurate controls to maintain telescope pointing over long integration periods. We propose an active solar shield system that harnesses radiation pressure to accurately slew and acquire new targets without the need for reaction wheels or thrusters. To provide the required torques, the solar shield is configured as an inverted, 4-sided pyramidal roof. The sloped roof interior surfaces are covered with hinged “tiles” made from piezoelectric film bimorphs with specular metallized surfaces. Nominally, the tiles lie flat against the roof and the sunlight is reflected outward equally from all sloped surfaces. However, when the tiles on one roof pitch are raised, the pressure balance is upset and the sunshade is pushed to one side. By judicious selection of the tiles and control of their lift angle, the solar pressure can be harvested to stabilize the spacecraft orientation or to change its angular momentum. A first order conceptual design performance analysis and the results from the experimental design, fabrication and testing of piezoelectric bimorph hinge elements will be presented. Next phase challenges in engineering design, materials technology, and systems testing will be discussed.

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

PubMed Central

Li, Shu-Ping; Wang, Yu-Wen; Qi, Sheng-Lan; Zhang, Yun-Peng; Deng, Gang; Ding, Wen-Zheng; Ma, Chao; Lin, Qi-Yan; Guan, Hui-Da; Liu, Wei; Cheng, Xue-Mei; Wang, Chang-Hong

2018-01-01

The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity, antioxidant, anti-inflammatory, and many others, and have great potential for treating Alzheimer’s disease (AD). However, studies have showed that the two compounds have similar structures and in vitro AChE inhibitory activities but with significant difference in bioavailability. The objective of this study was to comparatively investigate the effects of HAL and HAR in memory deficits of scopolamine-induced mice. In the present study, mice were pretreated with HAL (2, 5, and 10 mg/kg), HAR (10, 20, and 30 mg/kg) and donepezil (5 mg/kg) by intragastrically for 7 days, and were daily intraperitoneal injected with scopolamine (1 mg/kg) to induce memory deficits and then subjected to behavioral evaluation by Morris water maze. To further elucidate the underlying mechanisms of HAL and HAR in improving learning and memory, the levels of various biochemical factors and protein expressions related to cholinergic function, oxidative stress, and inflammation were examined. The results showed that HAL and HAR could effectively ameliorate memory deficits in scopolamine-induced mice. Both of them exhibited an enhancement in cholinergic function by inhibiting AChE and inducing choline acetyltransferase (ChAT) activities, and antioxidant defense via increasing the antioxidant enzymes activities of superoxide dismutase and glutathione peroxidase, and reducing maleic diadehyde production, and anti-inflammatory effects through suppressing myeloperoxidase, tumor necrosis factor α, and nitric oxide as well as modulation of critical neurotransmitters such as acetylcholine (ACh), choline (Ch), L-tryptophan (L-Trp), 5-hydroxytryptamine (5-HT), γ-aminobutyric acid (γ-GABA), and L-glutamic acid (L-Glu). Furthermore, the regulations of HAL on cholinergic function, inflammation, and neurotransmitters were more striking than those of HAR, and HAL manifested a comparable antioxidant capacity to HAR. Remarkably, the effective dosage of HAL (2 mg/kg) was far lower than that of HAR (20 mg/kg), which probably due to the evidently differences in the bioavailability and metabolic stability of the two analogs. Taken together, all these results revealed that HAL may be a promising candidate compound with better anti-amnesic effects and pharmacokinetic characteristics for the treatments of AD and related diseases. PMID:29755345

Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

PubMed Central

Kojima, Hiroyuki; Katsura, Eiji; Takeuchi, Shinji; Niiyama, Kazuhito; Kobayashi, Kunihiko

2004-01-01

We tested 200 pesticides, including some of their isomers and metabolites, for agonism and antagonism to two human estrogen receptor (hER) subtypes, hERalpha and hERbeta, and a human androgen receptor (hAR) by highly sensitive transactivation assays using Chinese hamster ovary cells. The test compounds were classified into nine groups: organochlorines, diphenyl ethers, organophosphorus pesticides, pyrethroids, carbamates, acid amides, triazines, ureas, and others. These pesticides were tested at concentrations < 10-5 M. Of the 200 pesticides tested, 47 and 33 showed hER- and hERbeta-mediated estrogenic activities, respectively. Among them, 29 pesticides had both hERalpha and hERbeta agonistic activities, and the effects of the organochlorine insecticides beta-benzene hexachloride (BHC) and delta-BHC and the carbamate insecticide methiocarb were predominantly hERbeta rather than hERalpha agonistic. Weak antagonistic effects toward hERalpha and hERbeta were shown in five and two pesticides, respectively. On the other hand, none of tested pesticides showed hAR-mediated androgenic activity, but 66 of 200 pesticides exhibited inhibitory activity against the transcriptional activity induced by 5alpha-dihydrotestosterone. In particular, the antiandrogenic activities of two diphenyl ether herbicides, chlornitrofen and chlomethoxyfen, were higher than those of vinclozolin and p,p -dichlorodiphenyl dichloroethylene, known AR antagonists. The results of our ER and AR assays show that 34 pesticides possessed both estrogenic and antiandrogenic activities, indicating pleiotropic effects on hER and hAR. We also discussed chemical structures related to these activities. Taken together, our findings suggest that a variety of pesticides have estrogenic and/or antiandrogenic potential via ER and/or AR, and that numerous other manmade chemicals may also possess such estrogenic and antiandrogenic activities. PMID:15064155

Environmental urban runoff monitoring

NASA Astrophysics Data System (ADS)

Yu, Byunggu; Behera, Pradeep K.; Kim, Seon Ho; Ramirez Rochac, Juan F.; Branham, Travis

2010-04-01

Urban stormwater runoff has been a critical and chronic problem in the quantity and quality of receiving waters, resulting in a major environmental concern. To address this problem engineers and professionals have developed a number of solutions which include various monitoring and modeling techniques. The most fundamental issue in these solutions is accurate monitoring of the quantity and quality of the runoff from both combined and separated sewer systems. This study proposes a new water quantity monitoring system, based on recent developments in sensor technology. Rather than using a single independent sensor, we harness an intelligent sensor platform that integrates various sensors, a wireless communication module, data storage, a battery, and processing power such that more comprehensive, efficient, and scalable data acquisition becomes possible. Our experimental results show the feasibility and applicability of such a sensor platform in the laboratory test setting.

Interference, focusing and excitation of ultracold atoms

NASA Astrophysics Data System (ADS)

Kandes, M. C.; Fahy, B. M.; Williams, S. R.; Tally, C. H., IV; Bromley, M. W. J.

2011-05-01

One of the pressing technological challenges in atomic physics is to go orders-of-magnitude beyond the limits of photon-based optics by harnessing the wave-nature of dilute clouds of ultracold atoms. We have developed parallelised algorithms to perform numerical calculations of the Gross-Pitaevskii equation in up to three dimensions and with up to three components to simulate Bose-Einstein condensates. A wide-ranging array of the physics associated with atom optics-based systems will be presented including BEC-based Sagnac interferometry in circular waveguides, the focusing of BECs using Laguerre-Gauss beams, and the interactions between BECs and Ince-Gaussian laser beams and their potential applications. One of the pressing technological challenges in atomic physics is to go orders-of-magnitude beyond the limits of photon-based optics by harnessing the wave-nature of dilute clouds of ultracold atoms. We have developed parallelised algorithms to perform numerical calculations of the Gross-Pitaevskii equation in up to three dimensions and with up to three components to simulate Bose-Einstein condensates. A wide-ranging array of the physics associated with atom optics-based systems will be presented including BEC-based Sagnac interferometry in circular waveguides, the focusing of BECs using Laguerre-Gauss beams, and the interactions between BECs and Ince-Gaussian laser beams and their potential applications. Performed on computational resources via NSF grants PHY-0970127, CHE-0947087 and DMS-0923278.

Neuromarkers for Mental Disorders: Harnessing Population Neuroscience.

PubMed

Jollans, Lee; Whelan, Robert

2018-01-01

Despite abundant research into the neurobiology of mental disorders, to date neurobiological insights have had very little impact on psychiatric diagnosis or treatment. In this review, we contend that the search for neuroimaging biomarkers-neuromarkers-of mental disorders is a highly promising avenue toward improved psychiatric healthcare. However, many of the traditional tools used for psychiatric neuroimaging are inadequate for the identification of neuromarkers. Specifically, we highlight the need for larger samples and for multivariate analysis. Approaches such as machine learning are likely to be beneficial for interrogating high-dimensional neuroimaging data. We suggest that broad, population-based study designs will be important for developing neuromarkers of mental disorders, and will facilitate a move away from a phenomenological definition of mental disorder categories and toward psychiatric nosology based on biological evidence. We provide an outline of how the development of neuromarkers should occur, emphasizing the need for tests of external and construct validity, and for collaborative research efforts. Finally, we highlight some concerns regarding the development, and use of, neuromarkers in psychiatric healthcare.

76 FR 6136 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... Beach, California; to acquire voting shares of HarVest BanCorp, Inc., Gaithersburg, Maryland, and thereby indirectly acquire voting shares of HarVest Bank of Maryland, Rockville, Maryland. Board of...

Flow Control in Wells Turbines for Harnessing Maximum Wave Power.

PubMed

Lekube, Jon; Garrido, Aitor J; Garrido, Izaskun; Otaola, Erlantz; Maseda, Javier

2018-02-10

Oceans, and particularly waves, offer a huge potential for energy harnessing all over the world. Nevertheless, the performance of current energy converters does not yet allow us to use the wave energy efficiently. However, new control techniques can improve the efficiency of energy converters. In this sense, the plant sensors play a key role within the control scheme, as necessary tools for parameter measuring and monitoring that are then used as control input variables to the feedback loop. Therefore, the aim of this work is to manage the rotational speed control loop in order to optimize the output power. With the help of outward looking sensors, a Maximum Power Point Tracking (MPPT) technique is employed to maximize the system efficiency. Then, the control decisions are based on the pressure drop measured by pressure sensors located along the turbine. A complete wave-to-wire model is developed so as to validate the performance of the proposed control method. For this purpose, a novel sensor-based flow controller is implemented based on the different measured signals. Thus, the performance of the proposed controller has been analyzed and compared with a case of uncontrolled plant. The simulations demonstrate that the flow control-based MPPT strategy is able to increase the output power, and they confirm both the viability and goodness.

Flow Control in Wells Turbines for Harnessing Maximum Wave Power

PubMed Central

Garrido, Aitor J.; Garrido, Izaskun; Otaola, Erlantz; Maseda, Javier

2018-01-01

Oceans, and particularly waves, offer a huge potential for energy harnessing all over the world. Nevertheless, the performance of current energy converters does not yet allow us to use the wave energy efficiently. However, new control techniques can improve the efficiency of energy converters. In this sense, the plant sensors play a key role within the control scheme, as necessary tools for parameter measuring and monitoring that are then used as control input variables to the feedback loop. Therefore, the aim of this work is to manage the rotational speed control loop in order to optimize the output power. With the help of outward looking sensors, a Maximum Power Point Tracking (MPPT) technique is employed to maximize the system efficiency. Then, the control decisions are based on the pressure drop measured by pressure sensors located along the turbine. A complete wave-to-wire model is developed so as to validate the performance of the proposed control method. For this purpose, a novel sensor-based flow controller is implemented based on the different measured signals. Thus, the performance of the proposed controller has been analyzed and compared with a case of uncontrolled plant. The simulations demonstrate that the flow control-based MPPT strategy is able to increase the output power, and they confirm both the viability and goodness. PMID:29439408

Experimental Characterization and Micromechanical Modeling of Woven Carbon/Copper Composites

NASA Technical Reports Server (NTRS)

Bednarcyk, Brett A.; Pauly, Christopher C.; Pindera, Marek-Jerzy

1997-01-01

The results of an extensive experimental characterization and a preliminary analytical modeling effort for the elastoplastic mechanical behavior of 8-harness satin weave carbon/copper (C/Cu) composites are presented. Previous experimental and modeling investigations of woven composites are discussed, as is the evolution of, and motivation for, the continuing research on C/Cu composites. Experimental results of monotonic and cyclic tension, compression, and Iosipescu shear tests, and combined tension-compression tests, are presented. With regard to the test results, emphasis is placed on the effect of strain gauge size and placement, the effect of alloying the copper matrix to improve fiber-matrix bonding, yield surface characterization, and failure mechanisms. The analytical methodology used in this investigation consists of an extension of the three-dimensional generalized method of cells (GMC-3D) micromechanics model, developed by Aboudi (1994), to include inhomogeneity and plasticity effects on the subcell level. The extension of the model allows prediction of the elastoplastic mechanical response of woven composites, as represented by a true repeating unit cell for the woven composite. The model is used to examine the effects of refining the representative geometry of the composite, altering the composite overall fiber volume fraction, changing the size and placement of the strain gauge with respect to the composite's reinforcement weave, and including porosity within the infiltrated fiber yarns on the in-plane elastoplastic tensile, compressive, and shear response of 8-harness satin C/Cu. The model predictions are also compared with the appropriate monotonic experimental results.

Teaching New Literacies in Grades 4-6: Resources for 21st-Century Classrooms

ERIC Educational Resources Information Center

Moss, Barbara, Ed.; Lapp, Diane, Ed.

2009-01-01

Upper-elementary students encounter a sometimes dizzying array of traditional and nontraditional texts both in and outside of the classroom. This practical handbook helps teachers in grades 4-6 harness the instructional potential of fiction, poetry, and plays; informational texts; graphic novels; digital storytelling; Web-based and multimodal…

Innovative Web-Based Professional Development for Teachers of At-Risk Preschool Children

ERIC Educational Resources Information Center

Kinzie, Mable B.; Whitaker, Stephen D.; Neesen, Kathy; Kelley, Michael; Matera, Michael; Pianta, Robert C.

2006-01-01

Research suggests the importance of professional development for teachers of at-risk children, and while educational technologies can be harnessed to help support teaching practice in innovative ways, such programs are often limited in scale. "My Teaching Partner (MTP)" was designed to deliver a targeted program of professional…

A Folksonomy-Based Lightweight Resource Annotation Metadata Schema for Personalized Hypermedia Learning Resource Delivery

ERIC Educational Resources Information Center

Lau, Simon Boung-Yew; Lee, Chien-Sing; Singh, Yashwant Prasad

2015-01-01

With the proliferation of social Web applications, users can now collaboratively author, share and access hypermedia learning resources, contributing to richer learning experiences outside formal education. These resources may or may not be educational. However, they can be harnessed for educational purposes by adapting and personalizing them to…

The Instructional Effects of Knowledge-Based Community of Practice Learning Environment on Student Achievement and Knowledge Convergence

ERIC Educational Resources Information Center

Draper, Darryl C.

2013-01-01

The increased accessibility of technology and Internet connections has enabled organizations to provide their workforces with the opportunity to engage in distributed education. "Harnessing this innovation calls for organizational and technological infrastructures that support the interplay of knowledge and knowing" (Cook & Brown, 1999, p. 381).…

Teachers' Concerns about Adopting Constructivist Online Game-Based Learning in Formal Curriculum Teaching: The VISOLE Experience

ERIC Educational Resources Information Center

Jong, Morris S. Y.

2016-01-01

Our work is set against the backdrop of the pervasive discussion of harnessing online games to provide students with new constructivist learning opportunities. Upon the theoretical foundation, we have developed Virtual Interactive Student-Oriented Learning Environment (VISOLE), a teaching framework for implementing constructivist online game-based…

Harnessing Solid-State Ionic Transport for Nanomanufacturing and Nanodevices

ERIC Educational Resources Information Center

Hsu, Keng Hao

2009-01-01

Through this work a new all-solid, ambient processing condition direct metal patterning technique has been developed and characterized. This ionic-transport-based patterning technique is capable of sub-50nm feature resolution under ambient conditions. It generates features with a rate that is comparable to conventional dry-etching techniques. A…

Global Realities: Celebrating Our Differences, Honoring Our Connections.

ERIC Educational Resources Information Center

Walz, Garry R., Ed.; Knowdell, Richard L., Ed.

This publication contains papers based on program presentations from the 2003 International Career Development Conference. Chapters include: (1) How to Turn Your Passion into a Profit (S. Abbott); (2) Harnessing the Power of Career Transition Groups (M. Adoradio and A. Oja); (3) All the Worlds a Stage Using Theatre in Career Counseling (P.…

Harnessing the Power of Technologies to Manage Collaborative e-Learning Projects in Dispersed Environments

ERIC Educational Resources Information Center

Gosper, Maree Veroncia; McNeill, Margot Anne; Woo, Karen

2010-01-01

"The impact of web-based lecture technologies on current and future practice in learning and teaching" was a collaborative project across four Australian universities, funded by the Australian Learning and Teaching Council (ALTC). The project was both exploratory and developmental in nature and according to the project's external…

Intertextualizing Interactive Texts for Critical Thinking: A South Korean EFL Experience

ERIC Educational Resources Information Center

Chandrasoma, Ranamukalage; Ananda, Lalith

2017-01-01

In the past three decades or so, the conceptual rigour of intertextuality has exercised enormous influence on pedagogical practices. In this context, intertextuality can also be used as a means of harnessing students' critical stances that are crucial for teaching language skills. Based on eight qualitative student interviews at a university in…

Inclusive Leadership Development: Drawing From Pedagogies of Women's and General Leadership Development Programs

ERIC Educational Resources Information Center

Sugiyama, Keimei; Cavanagh, Kevin V.; van Esch, Chantal; Bilimoria, Diana; Brown, Cara

2016-01-01

Trends in extant literature suggest that more relational and identity-based leadership approaches are necessary for leadership that can harness the benefits of the diverse and globalized workforces of today and the future. In this study, we compared general leadership development programs (GLDPs) and women's leadership development programs (WLDPs)…

Linguistic and Cultural Appropriations of an Immigrant Multilingual Literacy Teacher Educator

ERIC Educational Resources Information Center

Smith, Patriann; Warrican, S. Joel; Kumi-Yeboah, Alex

2016-01-01

This autoethnographic self-study describes my interpretations of multicultural awareness, with special attention to multilingual awareness (MLA), based on my interactions with 52 students in the context of two literacy courses over a period of one year. An autoethnographic self-study provided an avenue to harness my reflections on practice and to…

A Comparative Study of Collaborative Learning in "Paper Scribbles" and "Group Scribbles"

ERIC Educational Resources Information Center

Hao, Chen Fang

2010-01-01

"Paper Scribbles" (PS) consisting of markers, vanguard sheets and 3M "Post-It" notes, is a pedagogical tool to harness collective intelligence of groups for collaborative learning in the classroom. Borrowing the key features of PS and yet avoiding some of their physical limitations, a computer-based tool called "Group…

Stories about Struggling Readers and Technology

ERIC Educational Resources Information Center

Anderson, Rebecca; Balajthy, Ernest

2009-01-01

Educators have moved on from older models of technology-based education that focused on the attributes and basic uses of the hardware and software available to them. Now they are finding the necessary creative and innovative ways to harness technology's power for school and community educational improvement. In this column, the authors tell four…

Using E-Maps to Organize and Navigate Online Content

ERIC Educational Resources Information Center

Ruffini, Michael F.

2008-01-01

Computer-generated mind maps, or e-maps, provide an outstanding e-learning tool for organizing and navigating web-based content and files. Considerable research indicates the effectiveness of using graphic organizers such as mind maps to facilitate meaningful learning. Tony Buzan and Barry Buzan argue that mind maps better harness the way the…

Abasic pivot substitution harnesses target specificity of RNA interference

PubMed Central

Lee, Hye-Sook; Seok, Heeyoung; Lee, Dong Ha; Ham, Juyoung; Lee, Wooje; Youm, Emilia Moonkyung; Yoo, Jin Seon; Lee, Yong-Seung; Jang, Eun-Sook; Chi, Sung Wook

2015-01-01

Gene silencing via RNA interference inadvertently represses hundreds of off-target transcripts. Because small interfering RNAs (siRNAs) can function as microRNAs, avoiding miRNA-like off-target repression is a major challenge. Functional miRNA–target interactions are known to pre-require transitional nucleation, base pairs from position 2 to the pivot (position 6). Here, by substituting nucleotide in pivot with abasic spacers, which prevent base pairing and alleviate steric hindrance, we eliminate miRNA-like off-target repression while preserving on-target activity at ∼80–100%. Specifically, miR-124 containing dSpacer pivot substitution (6pi) loses seed-mediated transcriptome-wide target interactions, repression activity and biological function, whereas other conventional modifications are ineffective. Application of 6pi allows PCSK9 siRNA to efficiently lower plasma cholesterol concentration in vivo, and abolish potentially deleterious off-target phenotypes. The smallest spacer, C3, also shows the same improvement in target specificity. Abasic pivot substitution serves as a general means to harness the specificity of siRNA experiments and therapeutic applications. PMID:26679372

Recognizing stationary and locomotion activities using combinational of spectral analysis with statistical descriptors features

NASA Astrophysics Data System (ADS)

Zainudin, M. N. Shah; Sulaiman, Md Nasir; Mustapha, Norwati; Perumal, Thinagaran

2017-10-01

Prior knowledge in pervasive computing recently garnered a lot of attention due to its high demand in various application domains. Human activity recognition (HAR) considered as the applications that are widely explored by the expertise that provides valuable information to the human. Accelerometer sensor-based approach is utilized as devices to undergo the research in HAR since their small in size and this sensor already build-in in the various type of smartphones. However, the existence of high inter-class similarities among the class tends to degrade the recognition performance. Hence, this work presents the method for activity recognition using our proposed features from combinational of spectral analysis with statistical descriptors that able to tackle the issue of differentiating stationary and locomotion activities. The noise signal is filtered using Fourier Transform before it will be extracted using two different groups of features, spectral frequency analysis, and statistical descriptors. Extracted signal later will be classified using random forest ensemble classifier models. The recognition results show the good accuracy performance for stationary and locomotion activities based on USC HAD datasets.

Program for improved electrical harness documentation and fabrication

NASA Technical Reports Server (NTRS)

1971-01-01

Computer program provides automated print-out of harness interconnection table and automated cross-check of reciprocal pin/connector assignments, and improves accuracy and reliability of final documented data. Programs and corresponding library tapes are successfully and continuously employed on Nimbus spacecraft programs.

Manufacturing and quality control of interconnecting wire harnesses, Volume 2

NASA Technical Reports Server (NTRS)

1972-01-01

Interconnecting wire harnesses defined in the design standard are considered, including type 4, open bundle (not enclosed). Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into the document.

Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.

PubMed

Plett, P Artur; Sampson, Carol H; Chua, Hui Lin; Joshi, Mandar; Booth, Catherine; Gough, Alec; Johnson, Cynthia S; Katz, Barry P; Farese, Ann M; Parker, Jeffrey; MacVittie, Thomas J; Orschell, Christie M

2012-10-01

The authors have developed a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS) for efficacy testing of medical countermeasures (MCM) against radiation according to the FDA Animal Rule. Ten- to 12-wk-old male and female C57BL/6 mice were exposed to the LD50/30-LD70/30 dose of total body irradiation (TBI, (137)Cs, 0.62-0.67 Gy min(-1)) in the morning hours when mice were determined to be most radiosensitive, and they were assessed for 30-d survival and mean survival time (MST). Antibiotics were delivered in drinking water on days 4-30 post-TBI at a concentration based on the amount of water that lethally-irradiated mice were found to consume. The fluoroquinolones, ciprofloxacin and levofloxacin, as well as the tetracycline doxycycline, and aminoglycoside neomycin, all significantly increased MST of decedent mice, while ciprofloxacin (p = 0.061) and doxycycline + neomycin (p = 0.005) showed at least some efficacy to increase 30-d survival. Blood sampling (30 μL/mouse every fifth day) was found to negatively impact 30-d survival. Histopathology of tissues harvested from nonmoribund mice showed expected effects of lethal irradiation, while moribund mice were largely septicemic with a preponderance of enteric organisms. Kinetics of loss and recovery of peripheral blood cells in untreated mice and those treated with two MCM, granulocyte-colony stimulating factor and Amifostine further characterized and validated this model for use in screening studies and pivotal efficacy studies of candidate MCM for licensure to treat irradiated individuals suffering from H-ARS.

Post Hoc Analyses of Anxiety Measures in Adult Patients With Generalized Anxiety Disorder Treated With Vilazodone

PubMed Central

Khan, Arif; Durgam, Suresh; Tang, Xiongwen; Ruth, Adam; Mathews, Maju; Gommoll, Carl P.

2016-01-01

Objective To investigate vilazodone, currently approved for major depressive disorder in adults, for generalized anxiety disorder (GAD). Method Three randomized, double-blind, placebo-controlled studies showing positive results for vilazodone (2,040 mg/d) in adult patients with GAD (DSM-IV-TR) were pooled for analyses; data were collected from June 2012 to March 2014. Post hoc outcomes in the pooled intent-to-treat population (n = 1,462) included mean change from baseline to week 8 in Hamilton Anxiety Rating Scale (HARS) total score, psychic and somatic anxiety subscale scores, and individual item scores; HARS response (≥ 50% total score improvement) and remission (total score ≤ 7) at week 8; and category shifts, defined as HARS item score ≥ 2 at baseline (moderate to very severe symptoms) and score of 0 at week 8 (no symptoms). Results The least squares mean difference was statistically significant for vilazodone versus placebo in change from baseline to week 8 in HARS total score (−1.83, P < .0001) and in psychic anxiety (−1.21, P < .0001) and somatic anxiety (−0.63, P < .01) subscale scores; differences from placebo were significant on 11 of 14 HARS items (P < .05). Response rates were higher with vilazodone than placebo (48% vs 39%, P < .001), as were remission rates (27% vs 21%, P < .01). The percentage of patients who shifted to no symptoms was significant for vilazodone on several items: anxious mood, tension, intellectual, depressed mood, somatic-muscular, somatic-sensory, cardiovascular, respiratory, and autonomic symptoms (P < .05). Conclusions Treatment with vilazodone versus placebo was effective in adult GAD patients, with significant differences between treatment groups found on both psychic and somatic HARS items. Trial Registration ClinicalTrials.gov identifiers: NCT01629966, NCT01766401, NCT01844115. PMID:27486544

Post Hoc Analyses of Anxiety Measures in Adult Patients With Generalized Anxiety Disorder Treated With Vilazodone.

PubMed

Khan, Arif; Durgam, Suresh; Tang, Xiongwen; Ruth, Adam; Mathews, Maju; Gommoll, Carl P

2016-01-01

To investigate vilazodone, currently approved for major depressive disorder in adults, for generalized anxiety disorder (GAD). Three randomized, double-blind, placebo-controlled studies showing positive results for vilazodone (2,040 mg/d) in adult patients with GAD (DSM-IV-TR) were pooled for analyses; data were collected from June 2012 to March 2014. Post hoc outcomes in the pooled intent-to-treat population (n = 1,462) included mean change from baseline to week 8 in Hamilton Anxiety Rating Scale (HARS) total score, psychic and somatic anxiety subscale scores, and individual item scores; HARS response (≥ 50% total score improvement) and remission (total score ≤ 7) at week 8; and category shifts, defined as HARS item score ≥ 2 at baseline (moderate to very severe symptoms) and score of 0 at week 8 (no symptoms). The least squares mean difference was statistically significant for vilazodone versus placebo in change from baseline to week 8 in HARS total score (-1.83, P < .0001) and in psychic anxiety (-1.21, P < .0001) and somatic anxiety (-0.63, P < .01) subscale scores; differences from placebo were significant on 11 of 14 HARS items (P < .05). Response rates were higher with vilazodone than placebo (48% vs 39%, P < .001), as were remission rates (27% vs 21%, P < .01). The percentage of patients who shifted to no symptoms was significant for vilazodone on several items: anxious mood, tension, intellectual, depressed mood, somatic-muscular, somatic-sensory, cardiovascular, respiratory, and autonomic symptoms (P < .05). Treatment with vilazodone versus placebo was effective in adult GAD patients, with significant differences between treatment groups found on both psychic and somatic HARS items. ClinicalTrials.gov identifiers: NCT01629966, NCT01766401, NCT01844115.

Harnessing Multiple Internal Reflections to Design Highly Absorptive Acoustic Metasurfaces

NASA Astrophysics Data System (ADS)

Shen, Chen; Cummer, Steven A.

2018-05-01

The rapid development of metasurfaces has enabled numerous intriguing applications with acoustically thin sheets. Here we report the theory and experimental realization of a nonresonant sound-absorbing strategy using metasurfaces by harnessing multiple internal reflections. We theoretically and numerically show that the higher-order diffraction of thin gradient-index metasurfaces is tied to multiple internal reflections inside the unit cells. Highly absorbing acoustic metasurfaces can be realized by enforcing multiple internal reflections together with a small amount of loss. A reflective gradient-index acoustic metasurface is designed based on the theory, and we further experimentally verify the performance using a three-dimensional printed prototype. Measurements show over 99% energy absorption at the peak frequency and a 95% energy absorption bandwidth of around 600 Hz. The proposed mechanism provides an alternative route for sound absorption without the necessity of high absorption of the individual unit cells.

Adaptive and Resilient Soft Tensegrity Robots.

PubMed

Rieffel, John; Mouret, Jean-Baptiste

2018-04-17

Living organisms intertwine soft (e.g., muscle) and hard (e.g., bones) materials, giving them an intrinsic flexibility and resiliency often lacking in conventional rigid robots. The emerging field of soft robotics seeks to harness these same properties to create resilient machines. The nature of soft materials, however, presents considerable challenges to aspects of design, construction, and control-and up until now, the vast majority of gaits for soft robots have been hand-designed through empirical trial-and-error. This article describes an easy-to-assemble tensegrity-based soft robot capable of highly dynamic locomotive gaits and demonstrating structural and behavioral resilience in the face of physical damage. Enabling this is the use of a machine learning algorithm able to discover effective gaits with a minimal number of physical trials. These results lend further credence to soft-robotic approaches that seek to harness the interaction of complex material dynamics to generate a wealth of dynamical behaviors.

A distributed programming environment for Ada

NASA Technical Reports Server (NTRS)

Brennan, Peter; Mcdonnell, Tom; Mcfarland, Gregory; Timmins, Lawrence J.; Litke, John D.

1986-01-01

Despite considerable commercial exploitation of fault tolerance systems, significant and difficult research problems remain in such areas as fault detection and correction. A research project is described which constructs a distributed computing test bed for loosely coupled computers. The project is constructing a tool kit to support research into distributed control algorithms, including a distributed Ada compiler, distributed debugger, test harnesses, and environment monitors. The Ada compiler is being written in Ada and will implement distributed computing at the subsystem level. The design goal is to provide a variety of control mechanics for distributed programming while retaining total transparency at the code level.

42 CFR 84.173 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE... construction; minimum requirements. (a) Each respirator shall, where necessary, be equipped with a suitable...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.78 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.78 Section 84.78 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

Harnessing Collaborative Annotations on Online Formative Assessments

ERIC Educational Resources Information Center

Lin, Jian-Wei; Lai, Yuan-Cheng

2013-01-01

This paper harnesses collaborative annotations by students as learning feedback on online formative assessments to improve the learning achievements of students. Through the developed Web platform, students can conduct formative assessments, collaboratively annotate, and review historical records in a convenient way, while teachers can generate…

Manufacture and quality control of interconnecting wire harnesses

NASA Technical Reports Server (NTRS)

1973-01-01

Four-volume series of documents has been prepared as standard reference. Each volume may be used separately and covers wire and cable preparation as well as harness fabrication and installation. Series should be useful addition to libraries of manufactures of electrical and electronic equipment.

SRB Altitude Switch Assembly Wire Harness Failure

NASA Technical Reports Server (NTRS)

Blanche, Jim

2002-01-01

This paper presents an assessment of two wire harness failures that had occurred in Solid Rocket Booster Altitude Switch Assemblies S/N 200001 and S/N 20002. A list of modifications to EDU #4 and modification of qualification units 2000001 and 2000002 are also presented.

Identifying a Path Towards Rapid Discrimination of Infection Disease Outbreaks: Harnessing Next-Generation Sequencing Capabilities for Microbial Forensics

DTIC Science & Technology

2014-07-15

content typing, rep-PCR, pulsed-field gel electrophoresis, optical mapping, and antimicrobial susceptibility testing (G. Gault et al., 2011; P...Tremlett, G, Pidd, 2011). This case demonstrates the vulnerability of our food supply and why unusual outbreaks involving endemic microbes must be taken as... food products to malevolent tampering, and the widespread international economic consequences that can occur even from limited product contamination

USSR and Eastern Europe Scientific Abstracts, Chemistry, Number 56

DTIC Science & Technology

1977-07-06

U5.2:631.U5.4 THE EFFECT OF POTASSIUM UPON THE UTILIZATION OF AMMONIA NITROGEN IN A VEGETATION EXPERIMENT ON PEAT-PODZOLIC SOIL AND ON CHERNOZEM...upon the har- vest obtained in a vegetation experiment: not a single one of the tested methods of application of the fertilizers was accompanied by a...toxic agents into the organism, their movement in it, metabolism, distribution and excretion. A literature review covering physical-chemical methods

XM-1 Tank EMP Susceptibility and Survivability Test Program and Plan

DTIC Science & Technology

1980-11-01

electric field vector. The Vertical EMP Electromagnetic interference (EMI) shielding Simulator ( VEMPS ) produces a non-threat- is used on cable...polarized fields in the VEMPS to determine 2.3 Oveiall Program Activity Flow 5 , bulk current waveforms on interior cabling Figure 1 (p. 8) expresses...measured. The vertically polarized VEMPS the ground, it is not readily obvious how the will be used to measure harness sheath cur- currents on the

High-aspect-ratio microstructures with versatile slanting angles on silicon by uniform metal-assisted chemical etching

NASA Astrophysics Data System (ADS)

Li, Liyi; Zhang, Cheng; Tuan, Chia-Chi; Chen, Yun; Wong, C.-P.

2018-05-01

High-aspect-ratio (HAR) microstructures on silicon (Si) play key roles in photonics and electromechanical devices. However, it has been challenging to fabricate HAR microstructures with slanting profiles. Here we report successful fabrication of uniform HAR microstructures with controllable slanting angles on (1 0 0)-Si by slanted uniform metal-assisted chemical etching (SUMaCE). The trenches have width of 2 µm, aspect ratio greater than 20:1 and high geometric uniformity. The slanting angles can be adjusted between 2-70° with respect to the Si surface normal. The results support a fundamental hypothesis that under the UMaCE condition, the preferred etching direction is along the normal of the thin film catalysts, regardless of the relative orientation of the catalyst to Si substrates or the crystalline orientation of the substrates. The SUMaCE method paves the way to HAR 3D microfabrication with arbitrary slanting profiles inside Si.

A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice

PubMed Central

Kamm, Gretel B.; López-Leal, Rodrigo; Lorenzo, Juan R.; Franchini, Lucía F.

2013-01-01

The developmental brain gene NPAS3 stands out as a hot spot in human evolution because it contains the largest number of human-specific, fast-evolving, conserved, non-coding elements. In this paper we studied 2xHAR142, one of these elements that is located in the fifth intron of NPAS3. Using transgenic mice, we show that the mouse and chimp 2xHAR142 orthologues behave as transcriptional enhancers driving expression of the reporter gene lacZ to a similar NPAS3 expression subdomain in the mouse central nervous system. Interestingly, the human 2xHAR142 orthologue drives lacZ expression to an extended expression pattern in the nervous system. Thus, molecular evolution of 2xHAR142 provides the first documented example of human-specific heterotopy in the forebrain promoted by a transcriptional enhancer and suggests that it may have contributed to assemble the unique properties of the human brain. PMID:24218632

Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.

PubMed

Yang, Seung Won; Jang, Yo Han; Kwon, Soon Bin; Lee, Yoon Jae; Chae, Wonil; Byun, Young Ho; Kim, Paul; Park, Chan; Lee, Young Jae; Kim, Choon Kang; Kim, Young Seok; Choi, Seong Il; Seong, Baik Lin

2018-05-01

A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to some ribozymes and is operational during viral infections. Our purpose was to test whether influenza hemagglutinin (HA) can be assembled in a soluble, trimeric, and immunologically activating conformation by means of an RNA molecular chaperone (chaperna) activity. An RNA-interacting domain (RID) from the host being immunized was selected as a docking tag for RNA binding, which served as a transducer for the chaperna function for de novo folding and trimeric assembly of RID-HA1. Mutations that affect tRNA binding greatly increased the soluble aggregation defective in trimer assembly, suggesting that RNA interaction critically controls the kinetic network in the folding/assembly pathway. Immunization of mice resulted in strong hemagglutination inhibition and high titers of a neutralizing antibody, providing sterile protection against a lethal challenge and confirming the immunologically relevant HA conformation. The results may be translated into a rapid response to a new influenza pandemic. The harnessing of the novel chaperna described herein with immunologically tailored antigen-folding functions should serve as a robust prophylactic and diagnostic tool for viral infections.-Yang, S. W., Jang, Y. H., Kwon, S. B., Lee, Y. J., Chae, W., Byun, Y. H., Kim, P., Park, C., Lee, Y. J., Kim, C. K., Kim, Y. S., Choi, S. I., Seong, B. L. Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.

KSC-07pd3624

NASA Image and Video Library

2007-12-14

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A, a technician checks test wiring spliced into an electrical harness in space shuttle Atlantis' aft main engine compartment connected with the engine cut-off, or ECO, system. The test wiring leads to the interior of the mobile launcher platform where the Time Domain Reflectometry, or TDR, test equipment will be located to test the sensor system. The shuttle's planned launches on Dec. 6 and Dec. 9 were postponed because of false readings from the part of the ECO system that monitors the liquid hydrogen section of the tank. The liftoff date from NASA's Kennedy Space Center, Florida, is now targeted for Jan. 10, depending on the resolution of the problem in the fuel sensor system. Photo credit: NASA/Kim Shiflett

KSC-07pd3623

NASA Image and Video Library

2007-12-14

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A, a technician checks test wiring spliced into an electrical harness in space shuttle Atlantis' aft main engine compartment connected with the engine cut-off, or ECO, system. The test wiring leads to the interior of the mobile launcher platform where the Time Domain Reflectometry, or TDR, test equipment will be located to test the sensor system. The shuttle's planned launches on Dec. 6 and Dec. 9 were postponed because of false readings from the part of the ECO system that monitors the liquid hydrogen section of the tank. The liftoff date from NASA's Kennedy Space Center, Florida, is now targeted for Jan. 10, depending on the resolution of the problem in the fuel sensor system. Photo credit: NASA/Kim Shiflett

Very high temperature fiber processing and testing through the use of ultrahigh solar energy concentration

NASA Astrophysics Data System (ADS)

Jacobson, Benjamin A.; Gleckman, Philip L.; Holman, Robert L.; Sagie, Daniel; Winston, Roland

1991-10-01

We have demonstrated the feasibility of a high temperature cool-wall optical furnace that harnesses the unique power of concentrated solar heating for advanced materials processing and testing. Out small-scale test furnace achieved temperatures as high as 2400 C within a 10 mm X 0.44 mm cylindrical hot-zone. Optimum performance and efficiency resulted from an innovative two-stage optical design using a long-focal length, point-focus, conventional primary concentrator and a non-imaging secondary concentrator specifically designed for the cylindrical geometry of the target fiber. A scale-up analysis suggests that even higher temperatures can be achieved over hot zones large enough for practical commercial fiber post- processing and testing.

KSC-07pd3625

NASA Image and Video Library

2007-12-14

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A, a technician checks test wiring spliced into an electrical harness in space shuttle Atlantis' aft main engine compartment connected with the engine cut-off, or ECO, system. The test wiring leads to the interior of the mobile launcher platform where the Time Domain Reflectometry, or TDR, test equipment will be located to test the sensor system. The shuttle's planned launches on Dec. 6 and Dec. 9 were postponed because of false readings from the part of the ECO system that monitors the liquid hydrogen section of the tank. The liftoff date from NASA's Kennedy Space Center, Florida, is now targeted for Jan. 10, depending on the resolution of the problem in the fuel sensor system. Photo credit: NASA/Kim Shiflett

How can developing countries harness biotechnology to improve health?

PubMed Central

Daar, Abdallah S; Berndtson, Kathryn; Persad, Deepa L; Singer, Peter A

2007-01-01

Background The benefits of genomics and biotechnology are concentrated primarily in the industrialized world, while their potential to combat neglected diseases in the developing world has been largely untapped. Without building developing world biotechnology capacity to address local health needs, this disparity will only intensify. To assess the potential of genomics to address health needs in the developing world, the McLaughlin-Rotman Centre for Global Health, along with local partners, organized five courses on Genomics and Public Health Policy in the developing world. The overall objective of the courses was to collectively explore how to best harness genomics to improve health in each region. This article presents and analyzes the recommendations from all five courses. Discussion In this paper we analyze recommendations from 232 developing world experts from 58 countries who sought to answer how best to harness biotechnology to improve health in their regions. We divide their recommendations into four categories: science; finance; ethics, society and culture; and politics. Summary The Courses' recommendations can be summarized across the four categories listed above: Science - Collaborate through national, regional, and international networks - Survey and build capacity based on proven models through education, training, and needs assessments Finance - Develop regulatory and intellectual property frameworks for commercialization of biotechnology - Enhance funding and affordability of biotechnology - Improve the academic-industry interface and the role of small and medium enterprise Ethics, Society, Culture - Develop public engagement strategies to inform and educate the public about developments in genomics and biotechnology - Develop capacity to address ethical, social and cultural issues - Improve accessibility and equity Politics - Strengthen understanding, leadership and support at the political level for biotechnology - Develop policies outlining national biotechnology strategy These recommendations provide guidance for all those interested in supporting science, technology, and innovation to improve health in the developing world. Applying these recommendations broadly across sectors and regions will empower developing countries themselves to harness the benefits of biotechnology and genomics for billions who have long been excluded. PMID:18053180

In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molina-Molina, José-Manuel, E-mail: molinajm@ugr.es; Amaya, Esperanza; Grimaldi, Marina

Bisphenols are a group of chemicals structurally similar to bisphenol-A (BPA) in current use as the primary raw material in the production of polycarbonate and epoxy resins. Some bisphenols are intended to replace BPA in several industrial applications. This is the case of bisphenol-S (BPS), which has an excellent stability at high temperature and resistance to sunlight. Studies on the endocrine properties of BPS have focused on its interaction with human estrogen receptor alpha (hERα), but information on its interaction with other nuclear receptors is scarce. The aim of this study was to investigate interactions of BPS, BPF, BPA andmore » its halogenated derivatives, tetrachlorobisphenol A (TCBPA), and tetrabromobisphenol A (TBBPA), with human estrogen receptors (hERα and hERβ), androgen receptor (hAR), and pregnane X receptor (hPXR), using a panel of in vitro bioassays based on competitive binding to nuclear receptors (NRs), reporter gene expression, and cell proliferation assessment. BPS, BPF, and BPA efficiently activated both ERs, while TCBPA behaved as weak hERα agonist. Unlike BPF and BPA, BPS was more active in the hERβ versus hERα assay. BPF and BPA were full hAR antagonists (BPA > BPF), whereas BPA and BPS were weak hAR agonists. Only BPA, TCBPA, and TBBPA, were hPXR agonists (TCBPA > TBBPA > BPA). These findings provide evidence that BPA congeners and derivatives disrupt multiple NRs and may therefore interfere with the endocrine system. Hence, further research is needed to evaluate the potential endocrine-disrupting activity of putative BPA substitutes. - Highlights: • We investigated the agonist/antagonist activities of BPS, BPF, BPA, TCBPA and TBBPA. • The direct interaction of these compounds with hERα, hERβ, hAR and hPXR was studied. • BPA congeners and derivatives were found to disrupt multiple NRs. • Further evaluation of their role as endocrine-disrupting chemicals is needed.« less

How can developing countries harness biotechnology to improve health?

PubMed

Daar, Abdallah S; Berndtson, Kathryn; Persad, Deepa L; Singer, Peter A

2007-12-03

The benefits of genomics and biotechnology are concentrated primarily in the industrialized world, while their potential to combat neglected diseases in the developing world has been largely untapped. Without building developing world biotechnology capacity to address local health needs, this disparity will only intensify. To assess the potential of genomics to address health needs in the developing world, the McLaughlin-Rotman Centre for Global Health, along with local partners, organized five courses on Genomics and Public Health Policy in the developing world. The overall objective of the courses was to collectively explore how to best harness genomics to improve health in each region. This article presents and analyzes the recommendations from all five courses. In this paper we analyze recommendations from 232 developing world experts from 58 countries who sought to answer how best to harness biotechnology to improve health in their regions. We divide their recommendations into four categories: science; finance; ethics, society and culture; and politics. The Courses' recommendations can be summarized across the four categories listed above: SCIENCE: - Collaborate through national, regional, and international networks- Survey and build capacity based on proven models through education, training, and needs assessments FINANCE: - Develop regulatory and intellectual property frameworks for commercialization of biotechnology- Enhance funding and affordability of biotechnology- Improve the academic-industry interface and the role of small and medium enterprise ETHICS, SOCIETY, CULTURE: - Develop public engagement strategies to inform and educate the public about developments in genomics and biotechnology- Develop capacity to address ethical, social and cultural issues- Improve accessibility and equity POLITICS: - Strengthen understanding, leadership and support at the political level for biotechnology- Develop policies outlining national biotechnology strategyThese recommendations provide guidance for all those interested in supporting science, technology, and innovation to improve health in the developing world. Applying these recommendations broadly across sectors and regions will empower developing countries themselves to harness the benefits of biotechnology and genomics for billions who have long been excluded.

Innovation in the Harnessing and Transfer of Technology: The Gran Mariscal de Ayacucho Foundation

ERIC Educational Resources Information Center

Lerner de Almea, Ruth

1977-01-01

Discusses the background, organization, success, problems, and functions of the Gran Mariscal de Ayacucho Foundation, Caracas, Venezuela, for producing human resources for the harnessing of scientific technology. The fellowship program supports study by students both at home and abroad. (SL)

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1138 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.121 - Head harnesses; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Head harnesses; minimum requirements. 84.121 Section 84.121 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.116 Section 84.116 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

Use of loading-unloading compression curves in medical device design

NASA Astrophysics Data System (ADS)

Ciornei, M. C.; Alaci, S.; Ciornei, F. C.; Romanu, I. C.

2017-08-01

The paper presents a method and experimental results regarding mechanical testing of soft materials. In order to characterize the mechanical behaviour of technological materials used in prosthesis, a large number of material constants are required, as well as the comparison to the original. The present paper proposes as methodology the comparison between compression loading-unloading curves corresponding to a soft biological tissue and to a synthetic material. To this purpose, a device was designed based on the principle of the dynamic harness test. A moving load is considered and the force upon the indenter is controlled for loading-unloading phases. The load and specimen deformation are simultaneously recorded. A significant contribution of this paper is the interpolation of experimental data by power law functions, a difficult task because of the instability of the system of equations to be optimized. Finding the interpolation function was simplified, from solving a system of transcendental equations to solving a unique equation. The characteristic parameters of the experimentally curves must be compared to the ones corresponding to actual tissue. The tests were performed for two cases: first, using a spherical punch, and second, for a flat-ended cylindrical punch.

Comparative feasibility of implementing rapid diagnostic test and microscopy for parasitological diagnosis of malaria in Uganda.

PubMed

Batwala, Vincent; Magnussen, Pascal; Nuwaha, Fred

2011-12-19

In Uganda, parasite-based diagnosis is recommended for every patient suspected to have malaria before prescribing anti-malarials. However, the majority of patients are still treated presumptively especially in low-level health units. The feasibility of implementing parasite-based diagnosis for uncomplicated malaria in rural health centres (HCs) was investigated with a view to recommending measures for scaling up the policy. Thirty HCs were randomized to implement parasite-based diagnosis based on rapid diagnostic tests [RDTs] (n = 10), blood microscopy (n = 10) and presumptive diagnosis (control arm) (n = 10). Feasibility was assessed by comparing the proportion of patients who received parasite-based diagnosis; with a positive malaria parasite-based diagnosis who received artemether-lumefantrine (AL); with a negative malaria parasite-based diagnosis who received AL; and patient waiting time. Clinicaltrials.gov: NCT00565071. 102, 087 outpatients were enrolled. Patients were more likely to be tested in the RDT 44, 565 (96.6%) than in microscopy arm 19, 545 (60.9%) [RR: 1.59]. RDTs reduced patient waiting time compared to microscopy and were more convenient to health workers and patients. Majority 23, 804 (99.7%) in presumptive arm were prescribed AL. All (100%) of patients who tested positive for malaria in RDT and microscopy arms were prescribed anti-malarials. Parasitological-based diagnosis significantly reduced AL prescription in RDT arm [RR: 0.62] and microscopy arm [RR: 0.72] compared to presumptive treatment. Among patients not tested in the two intervention arms, 12, 044 (96.1%) in microscopy and 965 (61.6%) in RDT arm were treated with AL [RR: 1.56]. Overall 10, 558 (29.4%) with negative results [5, 110 (23.4%) in RDT and 5, 448 (39.0%) in microscopy arms] were prescribed AL. It was more feasible to implement parasite-based diagnosis for malaria using RDT than with microscopy. A high proportion of patients with negative malaria results are still prescribed anti-malarials. There is need to increase access to parasite-based diagnosis where microscopy is used. In order to fully harness the benefits of parasitological confirmation of malaria, it is necessary to reduce the prescription of anti-malarials in negative patients.

29. DETAIL OF OUTLET DUCTS FOR MST AIRCONDITIONING SYSTEM IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. DETAIL OF OUTLET DUCTS FOR MST AIR-CONDITIONING SYSTEM IN NORTHWEST CORNER OF SLC-3W MST STATION 70.5 (LOWEST PAYLOAD SERVICE STATION). NOTE RING ATTACHMENT FOR PERSONNEL SAFETY HARNESS IN LEFT FOREGROUND. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Solar Radiation: Harnessing the Power

ERIC Educational Resources Information Center

Rowland, Teri; Chambers, Lin; Holzer, Missy; Moore, Susan

2009-01-01

My NASA Data (Chambers et al. 2008) is a teaching tool available on NASA's website that offers microsets of real data in an easily accessible, user-friendly format. In this article, the authors describe a lesson plan based on an activity from My NASA Data, in which students explore parts of the United States where they would want to live if they…

Multilevel Dynamic Systems Affecting Introduction of HIV/STI Prevention Innovations among Chinese Women in Sex Work Establishments

ERIC Educational Resources Information Center

Weeks, Margaret R.; Li, Jianghong; Liao, Susu; Zhang, Qingning; Dunn, Jennifer; Wang, Yanhong; Jiang, Jingmei

2013-01-01

Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding and to harness the forces of change within complex, multilevel systems that affect community intervention implementation, effects, and sustainability. Building a system dynamics model based on ethnographic case study has the…

Monsters, Microbiology and Mathematics: The Epidemiology of a Zombie Apocalypse

ERIC Educational Resources Information Center

Verran, J.; Crossley, M.; Carolan, K.; Jacobs, N.; Amos, M.

2014-01-01

The aim of this learning exercise was to harness current interest in zombies in order to educate audiences about the epidemiology of infectious disease. Participants in the activity were provided with an outbreak scenario, which they then used as the basis of play-based activities. By considering the mode and speed of transmission, size of…

Enhancing Formal E-Learning with Edutainment on Social Networks

ERIC Educational Resources Information Center

Labus, A.; Despotovic-Zrakic, M.; Radenkovic, B.; Bogdanovic, Z.; Radenkovic, M.

2015-01-01

This paper reports on the investigation of the possibilities of enhancing the formal e-learning process by harnessing the potential of informal game-based learning on social networks. The goal of the research is to improve the outcomes of the formal learning process through the design and implementation of an educational game on a social network…

Effectively Adapting the Sport Management Curricula: Harnessing Internal and External Resources to Address Industry-Specific Needs

ERIC Educational Resources Information Center

Braunstein-Minkove, Jessica R.; DeLuca, Jaime R.

2015-01-01

Academic programs must constantly evolve in order to ensure that students are best prepared for success in internships and subsequent post-collegiate endeavors within the dynamic, rapidly changing sport industry. Based upon qualitative research, this work assesses and recommends areas of development in sport management curricula using internal and…

Harnessing Technology to Support Learning

ERIC Educational Resources Information Center

Richardson, Tony; Ecclesfield, Nigel; Lewis, Christine

2008-01-01

In April 2008, one sees the start of the consultation on the second phase of the government's e-strategy for education, published in 2005 as "Harnessing technology: transforming learning and children's services." This follows hard on the heels of the progress report and implementation plan for the technology strategy for further…

The Belem Framework for Action: Harnessing the Power and Potential of Adult Learning and Education for a Viable Future

ERIC Educational Resources Information Center

Adult Learning, 2012

2012-01-01

This article presents the Belem Framework for Action. This framework focuses on harnessing the power and potential of adult learning and education for a viable future. This framework begins with a preamble on adult education and towards lifelong learning.

Manufacture and quality control of interconnecting wire harnesses, Volume 3

NASA Technical Reports Server (NTRS)

1972-01-01

The document covers interconnecting wire harnesses defined in the design standard, including type 6, enclosed in TFE heat shrink tubing; and type 7, flexible armored. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into this document.

Experimental impact protection with advanced restraint systems : preliminary primate with air bag and inertia reel/inverted-y yoke torso harness.

DOT National Transportation Integrated Search

1969-02-01

Both the inverted-Y yoke torso harness with inertia reel and the air- bag restraint system have had extensive independent development for some time by several engineering and research organizations for both aviation and ground vehicle occupant protec...

Harnessing Linguistic Variation to Improve Education. Rethinking Education. Volume 5

ERIC Educational Resources Information Center

Yiakoumetti, Androula, Ed.

2012-01-01

This volume brings together research carried out in a variety of geographic and linguistic contexts including Africa, Asia, Australia, Canada, the Caribbean, Europe and the United States and explores efforts to incorporate linguistic diversity into education and to "harness" this diversity for learners' benefit. It challenges the largely…

77 FR 11791 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... installation wiring. For the reasons described above, this [EASA] AD requires a one- time [detailed] inspection... installation, and if corrosion is found repairing each affected harness braid or replacing each affected component and/or wiring harness. We are proposing this AD to detect and correct corrosion of critical system...

77 FR 29855 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... electronic installation wiring. For the reasons described above, this [EASA] AD requires a one- time... corrosion of the electrical and electronics installation, and if corrosion is found repairing each affected harness braid or replacing each affected component and/or wiring harness. We are issuing this AD to detect...

Development of an intervention program to encourage shoulder harness use and aircraft retrofit in general aviation aircraft : phases I and II.

DOT National Transportation Integrated Search

1995-01-01

This report describes a study of shoulder harness installation and use rates in general aviation aircraft. Observations were made at six geographically separate areas to determine estimates of current installation and use rates. An expert panel was e...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.73 Section 84.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self...

Harness the Power of Technology

ERIC Educational Resources Information Center

Duncan, Arne

2011-01-01

Today, U.S. educators are teaching in the midst of a technological revolution. Technology promises to provide innovative solutions in the nation's classrooms, just as it has transformed the way people communicate, socialize, and conduct business. In this article, the author argues that now is the time to harness technology to revolutionize the way…

Personalizing Learning through the Use of Technology

ERIC Educational Resources Information Center

Robinson, Carol; Sebba, Judy

2010-01-01

In March 2005, the Department for Education and Skills published its e-strategy, Harnessing Technology (DfES, 2005, Harnessing technology: Transforming Learning and Children's Services). Within this, two of its key objectives were: firstly to transform teaching and learning, and help to improve outcomes for children and young people, through…

Reliable Wiring Harness

NASA Technical Reports Server (NTRS)

Gaspar, Kenneth C.

1987-01-01

New harness for electrical wiring includes plugs that do not loosen from vibration. Ground braids prevented from detaching from connectors and constrained so braids do not open into swollen "birdcage" sections. Spring of stainless steel encircles ground braid. Self-locking connector contains ratchet not only preventing connector from opening, but tightens when vibrated.

78 FR 28725 - Airworthiness Directives; Spectrolab Nightsun XP Searchlight

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... helicopter and remaining attached solely by the internal cable harness, or separating totally. This condition... Searchlight/ Gimbal could disconnect from the helicopter and remain attached solely by the internal cable harness or separate totally, resulting in damage to the helicopter or injury to persons on the ground...

77 FR 13993 - Airworthiness Directives; Spectrolab Nightsun XP Searchlight

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-08

.../Gimbal could disconnect from the helicopter and remain attached solely by the internal cable harness or... from the helicopter and remaining attached soley by the internal cable harness, or separating totally... incorporates two positive locking mechanisms: a torque value and safety wire applied to the nut. These locking...

African goat improvement project: A feed the future initiative harnessing geneticdiversity for conservation, disease resistance, and improved productivity

USDA-ARS?s Scientific Manuscript database

AFRICAN GOAT IMPROVEMENT PROJECT: A FEED THE FUTURE INITIATIVE HARNESSING GENETIC DIVERSITY FOR CONSERVATION, DISEASE RESISTANCE, AND IMPROVED PRODUCTIVITY Food production systems in Africa depend heavily on the use of locally adapted animals. These animals are of agricultural, cultural, and econom...

Finite element analysis of high aspect ratio wind tunnel wing model: A parametric study

NASA Astrophysics Data System (ADS)

Rosly, N. A.; Harmin, M. Y.

2017-12-01

Procedure for designing the wind tunnel model of a high aspect ratio (HAR) wing containing geometric nonlinearities is described in this paper. The design process begins with identification of basic features of the HAR wing as well as its design constraints. This enables the design space to be narrowed down and consequently, brings ease of convergence towards the design solution. Parametric studies in terms of the spar thickness, the span length and the store diameter are performed using finite element analysis for both undeformed and deformed cases, which respectively demonstrate the linear and nonlinear conditions. Two main criteria are accounted for in the selection of the wing design: the static deflections due to gravitational loading should be within the allowable margin of the size of the wind tunnel test section and the flutter speed of the wing should be much below the maximum speed of the wind tunnel. The findings show that the wing experiences a stiffness hardening effect under the nonlinear static solution and the presence of the store enables significant reduction in linear flutter speed.

A Comparison of Zoo Animal Behavior in the Presence of Familiar and Unfamiliar People.

PubMed

Martin, Rosemary Anne; Melfi, Vicky

2016-01-01

As recorded in domestic nonhuman animals, regular interactions between animals in zoos and keepers and the resulting relationship formed (human-animal relationship [HAR]) are likely to influence the animals' behaviors with associated welfare consequences. HAR formation requires that zoo animals distinguish between familiar and unfamiliar people. This ability was tested by comparing zoo animal behavioral responses to familiar (routine) keepers and unfamiliar keepers (participants in the "Keeper for the Day" program). Study subjects included 1 African elephant (Loxodonta Africana), 3 Rothschild's giraffes (Giraffa camelopardalis rothschildi), 2 Brazilian tapir (Tapirus terrestris), and 2 slender-tailed meerkats (Suricata suricatta). Different behavior was evident and observed as decreased avoidance behavior toward familiar keepers (t7 = 6.00, p <  .001). This finding suggests the zoo animals have a lower level of fear toward familiar keepers. Keeper familiarity did not significantly affect any other behavioral measure. This finding suggests that in the current study, unfamiliar keeper presence did not appear to have detrimental effects. Furthermore, unfamiliar keeper-animal interactions could provide an increased number of positive human-animal interactions and potentially enhance animal welfare.

Cryo-vacuum testing of the JWST Integrated Science Instrument Module (SPIE)

NASA Technical Reports Server (NTRS)

Kimble, Randy A.; Vila, M. Begona; Van Campen, Julie; Birkmann, Stephan M.; Comber, Brian J.; Fatig, Curtis C.; Glasse, Alistair C. H.; Glazer, Stuart D.; Kelly, Douglas M.; Mann, Steven D.;

Mars Science Laboratory Drill

NASA Technical Reports Server (NTRS)

Okon, Avi B.

2010-01-01

The Drill for the Mars Science Laboratory mission is a rotary-percussive sample acquisition device with an emphasis on toughness and robustness to handle the harsh environment on Mars. The unique challenges associated with autonomous drilling from a mobile robot are addressed. A highly compressed development schedule dictated a modular design architecture that satisfies the functional and load requirements while allowing independent development and testing of the Drill subassemblies. The Drill consists of four actuated mechanisms: a spindle that rotates the bit, a chuck that releases and engages bits, a novel voice-coil-based percussion mechanism that hammers the bit, and a linear translation mechanism. The Drill has three passive mechanisms: a replaceable bit assembly that acquires and collects sample, a contact sensor / stabilizer mechanism, and, lastly a flex harness service loop. This paper describes the various mechanisms that makeup the Drill and discusses the solutions to their unique design and development challenges.

Quantum simulator review

NASA Astrophysics Data System (ADS)

Bednar, Earl; Drager, Steven L.

2007-04-01

Quantum information processing's objective is to utilize revolutionary computing capability based on harnessing the paradigm shift offered by quantum computing to solve classically hard and computationally challenging problems. Some of our computationally challenging problems of interest include: the capability for rapid image processing, rapid optimization of logistics, protecting information, secure distributed simulation, and massively parallel computation. Currently, one important problem with quantum information processing is that the implementation of quantum computers is difficult to realize due to poor scalability and great presence of errors. Therefore, we have supported the development of Quantum eXpress and QuIDD Pro, two quantum computer simulators running on classical computers for the development and testing of new quantum algorithms and processes. This paper examines the different methods used by these two quantum computing simulators. It reviews both simulators, highlighting each simulators background, interface, and special features. It also demonstrates the implementation of current quantum algorithms on each simulator. It concludes with summary comments on both simulators.

A versatile fibre optic sensor interrogation system for the Ariane Launcher based on an electro-optically tuneable laser diode

NASA Astrophysics Data System (ADS)

Plattner, M. P.; Hirth, F.; Müller, M. S.; Hoffmann, L.; Buck, T. C.; Koch, A. W.

2017-11-01

Availability of reliable flight sensor data and knowledge of the structural behaviour are essential for safe operation of the Ariane launcher. The Ariane launcher is currently monitored by hundreds of electric sensors during test and qualification. Fibre optic sensors are regarded as a potential technique to overcome limitations of recent monitoring systems for the Ariane launcher [1]. These limitations include cumbersome application of sensors and harness as well as a very limited degree of distributed sensing capability. But, in order to exploit the various advantages of fibre optic sensors (high degree of multiplexing, distributed sensing capability, lower mass impact, etc.) dedicated measurement systems have to be developed and investigated. State-of-the-art fibre optic measurement systems often use free beam setups making them bulky and sensitive to vibration impact. Therefore a new measurement system is developed as part of the ESAstudy [2].

Qubit entanglement between ring-resonator photon-pair sources on a silicon chip

PubMed Central

Silverstone, J. W.; Santagati, R.; Bonneau, D.; Strain, M. J.; Sorel, M.; O'Brien, J. L.; Thompson, M. G.

2015-01-01

Entanglement—one of the most delicate phenomena in nature—is an essential resource for quantum information applications. Scalable photonic quantum devices must generate and control qubit entanglement on-chip, where quantum information is naturally encoded in photon path. Here we report a silicon photonic chip that uses resonant-enhanced photon-pair sources, spectral demultiplexers and reconfigurable optics to generate a path-entangled two-qubit state and analyse its entanglement. We show that ring-resonator-based spontaneous four-wave mixing photon-pair sources can be made highly indistinguishable and that their spectral correlations are small. We use on-chip frequency demultiplexers and reconfigurable optics to perform both quantum state tomography and the strict Bell-CHSH test, both of which confirm a high level of on-chip entanglement. This work demonstrates the integration of high-performance components that will be essential for building quantum devices and systems to harness photonic entanglement on the large scale. PMID:26245267

Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines

PubMed Central

Chin’ombe, Nyasha; Ruhanya, Vurayai

2013-01-01

HIV/AIDS is an important public health problem globally. An affordable, easy-to-deliver and protective HIV vaccine is therefore required to curb the pandemic from spreading further. Recombinant Salmonella bacteria can be harnessed to vector HIV antigens or DNA vaccines to the immune system for induction of specific protective immunity. These are capable of activating the innate, humoral and cellular immune responses at both mucosal and systemic compartments. Several studies have already demonstrated the utility of live recombinant Salmonella in delivering expressed foreign antigens as well as DNA vaccines to the host immune system. This review gives an overview of the studies in which recombinant Salmonella bacteria were used to vector HIV/AIDS antigens and DNA vaccines. Most of the recombinant Salmonella-based HIV/AIDS vaccines developed so far have only been tested in animals (mainly mice) and are yet to reach human trials. PMID:24478808

Science to Practice: IT Solutions to Drive Standardized Report Recommendations for Abdominal Aortic Aneurysm Surveillance.

PubMed

Kim, Danny C; Herskovits, Edward H; Johnson, Pamela T

2018-06-01

Inadequate imaging surveillance has been identified as the most significant contributor to abdominal aortic aneurysm (AAA) rupture. Radiologists can contribute value to patient care and reduce morbidity and mortality related to AAA by incorporating evidence-based management recommendations from the ACR and Society of Vascular Surgery into their report impression. The challenges lie in achieving 100% radiologist compliance to incorporate the recommendations and ensuring that the patient is notified by their provider, the follow-up examination is scheduled, and the patient returns for an imaging test that may be scheduled 3 to 5 years in the future. To address these barriers, radiology quality and informatics leads have harnessed IT solutions to facilitate integration of content, communication of results, and patient follow-up. Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.

XRootD popularity on hadoop clusters

NASA Astrophysics Data System (ADS)

Meoni, Marco; Boccali, Tommaso; Magini, Nicolò; Menichetti, Luca; Giordano, Domenico; CMS Collaboration

2017-10-01

Performance data and metadata of the computing operations at the CMS experiment are collected through a distributed monitoring infrastructure, currently relying on a traditional Oracle database system. This paper shows how to harness Big Data architectures in order to improve the throughput and the efficiency of such monitoring. A large set of operational data - user activities, job submissions, resources, file transfers, site efficiencies, software releases, network traffic, machine logs - is being injected into a readily available Hadoop cluster, via several data streamers. The collected metadata is further organized running fast arbitrary queries; this offers the ability to test several Map&Reduce-based frameworks and measure the system speed-up when compared to the original database infrastructure. By leveraging a quality Hadoop data store and enabling an analytics framework on top, it is possible to design a mining platform to predict dataset popularity and discover patterns and correlations.

Rapid automated classification of anesthetic depth levels using GPU based parallelization of neural networks.

PubMed

Peker, Musa; Şen, Baha; Gürüler, Hüseyin

2015-02-01

The effect of anesthesia on the patient is referred to as depth of anesthesia. Rapid classification of appropriate depth level of anesthesia is a matter of great importance in surgical operations. Similarly, accelerating classification algorithms is important for the rapid solution of problems in the field of biomedical signal processing. However numerous, time-consuming mathematical operations are required when training and testing stages of the classification algorithms, especially in neural networks. In this study, to accelerate the process, parallel programming and computing platform (Nvidia CUDA) facilitates dramatic increases in computing performance by harnessing the power of the graphics processing unit (GPU) was utilized. The system was employed to detect anesthetic depth level on related electroencephalogram (EEG) data set. This dataset is rather complex and large. Moreover, the achieving more anesthetic levels with rapid response is critical in anesthesia. The proposed parallelization method yielded high accurate classification results in a faster time.

Making Games Not Work: Paradoxes Embedded in Game-Based Training and Concepts for Overcoming Them

NASA Technical Reports Server (NTRS)

Jones, Phillip N.; Cuper, Taryn

2010-01-01

An interest in game-based training solutions is natural. All one has to do is watch someone fully engaged in a modern game to see the potential of harnessing that attention for training. However, the reality of game-based training has not fully satisfied these expectations. This paper explains two paradoxes that must be overcome for games to support training. These paradoxes are a result of the realities of the basic human condition clashing with the requirements of learning theory. 80th paradoxes arise from the concept of "engagement" that is central to games. The first comes from a more robust definition of engagement, which is the condition of Flow or Optimal Experience. Flow is the state game developers want to see in users. One aspect of Flow is loss of sense of self as the individual becomes immersed in the experience. The paradox arises because this loss of self directly contradicts the learning requirement of self-reflection. The second paradox comes from theories of play, which state in part that play requires a level of individual freedom. The contradiction arises when game-based play must be harnessed to an organizational training program or regimen. The paper will discuss these paradoxes in the context of an effort to design a game-based training modality to train combat medics and will close with a review of compensating strategies identified by the designers. The paper will provide information important to anyone interested in conceptualizing and designing game-based training.

Archeological Survey and Testing Along Boone Creek, Louisiana Army Ammunition Plant, Webster Parish, Louisiana

DTIC Science & Technology

1989-01-01

ducks, partridges, cranes , quail, snakes, and fish. 8 CHAPTER 2: ENVIRONMENTAL SETTING Climate The modern climate of the project area is classified as... caustic materials. Large openings in their sides were cut by oil field workers, who then added water to the dry caustic material to make a caustic ...whiffletree hook and a harness ring were recovered, indicating that horses were used here. No automotive artifacts were recovered. This again reinforces the

STE/ICE (Simplified Test Equipment/Internal Combustion Engines) Design Guide for Vehicle Diagnostic Connector Assemblies

DTIC Science & Technology

1982-08-01

19 3.2 Diesel Engine Speed Transducer 20 3.3 Pressure Transducer 20 3.4 Temperature Transducer 22 3.5 Differential Pressure Switch 22 3.6 Differential... Pressure Switch , Multi-Point 22 3.7 Current Measurement Transducer 23 - 3.8 Electrolyte Level Probes 23 3.9 Diagnostic Connector 24 3.10 Harness...12258933 Differential Pressure Switch - Multi-point 12258934 K -. Differential Pressure Switch 12258938 Electrolyte Level Sensor 12258935 Shunt 1000

Army Net Zero Prove Out. Army Net Zero Training Report

DTIC Science & Technology

2014-11-20

existing reporting systems (e.g., Army Energy and Water Reporting System, Solid Waste Annual Reporting- web , Headquarters Army Environmental System). 3...Testing a wave energy converter  Harnesses the pressure of a wave on the ocean floor 22  Conduct thermal building envelope analysis  IR ...bathroom f ixtures, ai r handling units, Less than 3𔄃W i rrigat ion controls w ith EPA Water’Sense approved equipment 1% 0 . .279% Acqu ire lower water

An Attachable Electromagnetic Energy Harvester Driven Wireless Sensing System Demonstrating Milling-Processes and Cutter-Wear/Breakage-Condition Monitoring.

PubMed

Chung, Tien-Kan; Yeh, Po-Chen; Lee, Hao; Lin, Cheng-Mao; Tseng, Chia-Yung; Lo, Wen-Tuan; Wang, Chieh-Min; Wang, Wen-Chin; Tu, Chi-Jen; Tasi, Pei-Yuan; Chang, Jui-Wen

2016-02-23

An attachable electromagnetic-energy-harvester driven wireless vibration-sensing system for monitoring milling-processes and cutter-wear/breakage-conditions is demonstrated. The system includes an electromagnetic energy harvester, three single-axis Micro Electro-Mechanical Systems (MEMS) accelerometers, a wireless chip module, and corresponding circuits. The harvester consisting of magnets with a coil uses electromagnetic induction to harness mechanical energy produced by the rotating spindle in milling processes and consequently convert the harnessed energy to electrical output. The electrical output is rectified by the rectification circuit to power the accelerometers and wireless chip module. The harvester, circuits, accelerometer, and wireless chip are integrated as an energy-harvester driven wireless vibration-sensing system. Therefore, this completes a self-powered wireless vibration sensing system. For system testing, a numerical-controlled machining tool with various milling processes is used. According to the test results, the system is fully self-powered and able to successfully sense vibration in the milling processes. Furthermore, by analyzing the vibration signals (i.e., through analyzing the electrical outputs of the accelerometers), criteria are successfully established for the system for real-time accurate simulations of the milling-processes and cutter-conditions (such as cutter-wear conditions and cutter-breaking occurrence). Due to these results, our approach can be applied to most milling and other machining machines in factories to realize more smart machining technologies.