Science.gov

Sample records for hat hypergeometric analysis

  1. Shear buckling analysis of a hat-stiffened panel

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Jackson, Raymond H.

    1994-01-01

    A buckling analysis was performed on a hat-stiffened panel subjected to shear loading. Both local buckling and global buckling were analyzed. The global shear buckling load was found to be several times higher than the local shear buckling load. The classical shear buckling theory for a flat plate was found to be useful in predicting the local shear buckling load of the hat-stiffened panel, and the predicted local shear buckling loads thus obtained compare favorably with the results of finite element analysis.

  2. Compressive buckling analysis of hat-stiffened panel

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Jackson, Raymond H.

    1991-01-01

    Buckling analysis was performed on a hat-stiffened panel subjected to uniaxial compression. Both local buckling and global buckling were analyzed. It was found that the global buckling load was several times higher than the buckling load. The predicted local buckling loads compared favorably with both experimental data and finite-element analysis.

  3. Nonparaxial hypergeometric beams

    NASA Astrophysics Data System (ADS)

    Kotlyar, V. V.; Kovalev, A. A.

    2009-04-01

    We derive an analytical expression to describe the exact solution of the Helmholtz equation in cylindrical coordinates as a product of two Kummer functions. The solution is presented as a sum of two terms that describe the nonparaxial hypergeometric light beams propagated along the optical axis in the positive and negative directions. With the distance from the initial plane becoming much larger than the wavelength of light, the expression derived for the nonparaxial hypergeometric beam coincides with that for a paraxial hypergeometric mode.

  4. MyriMatch: highly accurate tandem mass spectral peptide identification by multivariate hypergeometric analysis

    PubMed Central

    Tabb, David L.; Fernando, Christopher G.; Chambers, Matthew C.

    2008-01-01

    Shotgun proteomics experiments are dependent upon database search engines to identify peptides from tandem mass spectra. Many of these algorithms score potential identifications by evaluating the number of fragment ions matched between each peptide sequence and an observed spectrum. These systems, however, generally do not distinguish between matching an intense peak and matching a minor peak. We have developed a statistical model to score peptide matches that is based upon the multivariate hypergeometric distribution. This scorer, part of the “MyriMatch” database search engine, places greater emphasis on matching intense peaks. The probability that the best match for each spectrum has occurred by random chance can be employed to separate correct matches from random ones. We evaluated this software on data sets from three different laboratories employing three different ion trap instruments. Employing a novel system for testing discrimination, we demonstrate that stratifying peaks into multiple intensity classes improves the discrimination of scoring. We compare MyriMatch results to those of Sequest and X!Tandem, revealing that it is capable of higher discrimination than either of these algorithms. When minimal peak filtering is employed, performance plummets for a scoring model that does not stratify matched peaks by intensity. On the other hand, we find that MyriMatch discrimination improves as more peaks are retained in each spectrum. MyriMatch also scales well to tandem mass spectra from high-resolution mass analyzers. These findings may indicate limitations for existing database search scorers that count matched peaks without differentiating them by intensity. This software and source code is available under Mozilla Public License at this URL: http://www.mc.vanderbilt.edu/msrc/bioinformatics/. PMID:17269722

  5. Supplement to the UMTRA Project water sampling and analysis plan, Mexican Hat, Utah

    SciTech Connect

    1995-09-01

    This water sampling and analysis plan (WSAP) supplement supports the regulatory and technical basis for water sampling at the Mexican Hat, Utah, Uranium Mill Tailings Remedial Action (UMTRA) Project site, as defined in the 1994 WSAP document for Mexican Hat (DOE, 1994). Further, the supplement serves to confirm our present understanding of the site relative to the hydrogeology and contaminant distribution as well as our intention to continue to use the sampling strategy as presented in the 1994 WSAP document for Mexican Hat. Ground water and surface water monitoring activities are derived from the US Environmental Protection Agency regulations in 40 CFR Part 192 (1991) and 60 FR 2854 (1995). Sampling procedures are guided by the UMTRA Project standard operating procedures (JEG, n.d.), the Technical Approach Document (DOE, 1989), and the most effective technical approach for the site. Additional site-specific documents relevant to the Mexican Hat site are the Mexican Hat Long-Term Surveillance Plan (currently in progress), and the Mexican Hat Site Observational Work Plan (currently in progress).

  6. Identities for generalized hypergeometric coefficients

    SciTech Connect

    Biedenharn, L.C.; Louck, J.D.

    1991-01-01

    Generalizations of hypergeometric functions to arbitrarily many symmetric variables are discussed, along with their associated hypergeometric coefficients, and the setting within which these generalizations arose. Identities generalizing the Euler identity for {sub 2}F{sub 1}, the Saalschuetz identity, and two generalizations of the {sub 4}F{sub 3} Bailey identity, among others, are given. 16 refs.

  7. Transit timing analysis in the HAT-P-32 system

    NASA Astrophysics Data System (ADS)

    Seeliger, M.; Dimitrov, D.; Kjurkchieva, D.; Mallonn, M.; Fernandez, M.; Kitze, M.; Casanova, V.; Maciejewski, G.; Ohlert, J. M.; Schmidt, J. G.; Pannicke, A.; Puchalski, D.; Göğüş, E.; Güver, T.; Bilir, S.; Ak, T.; Hohle, M. M.; Schmidt, T. O. B.; Errmann, R.; Jensen, E.; Cohen, D.; Marschall, L.; Saral, G.; Bernt, I.; Derman, E.; Gałan, C.; Neuhäuser, R.

    2014-06-01

    We present the results of 45 transit observations obtained for the transiting exoplanet HAT-P-32b. The transits have been observed using several telescopes mainly throughout the YETI (Young Exoplanet Transit Initiative) network. In 25 cases, complete transit light curves with a timing precision better than 1.4 min have been obtained. These light curves have been used to refine the system properties, namely inclination i, planet-to-star radius ratio Rp/Rs, and the ratio between the semimajor axis and the stellar radius a/Rs. First analyses by Hartman et al. suggests the existence of a second planet in the system, thus we tried to find an additional body using the transit timing variation (TTV) technique. Taking also the literature data points into account, we can explain all mid-transit times by refining the linear ephemeris by 21 ms. Thus, we can exclude TTV amplitudes of more than ˜1.5 min.

  8. Analysis of HAT-P-2b Warm Spitzer Full Orbit Light Curve

    NASA Astrophysics Data System (ADS)

    Lewis, Nikole; Knuston, H.; Showman, A. P.; Fortney, J. J.; Agol, E.; Burrows, A.; Charbonneau, D.; Cowan, N. B.; Deming, D.; Desert, J.; Langton, J.; Laughlin, G.; Mighell, K. J.

    2011-05-01

    The Spitzer warm mission has already greatly expanded the field of exoplanet characterization with over 3000 hours of time dedicated to exoplanet observations. Observations of eclipsing systems with Spitzer are at the heart of these advances, as they allow us to move beyond simple mass and period estimates to determine planetary radius, dayside emission, and emission variations as a function of orbital phase. The eclipsing system HAT-P-2 is of special interest because the massive Jovian sized planet in this system is on a highly eccentric orbit (e=0.5171). Because HAT-P-2b's orbit is eccentric, the planet is subject to time variable heating and probable non-synchronous rotation. Circulation patterns that we expect to develop in HAT-P-2b's atmosphere will likely vary with both planetary local time and orbital phase. Here we present an analysis of a full orbit light curve from the HAT-P-2 system obtained during the most recent cycle of the Spitzer warm mission and discuss the constraints it imposes on the atmospheric circulation of HAT-P-2b. Support for this work was provided by NASA.

  9. Multivariate Hypergeometric Similarity Measure

    PubMed Central

    Kaddi, Chanchala D.; Parry, R. Mitchell; Wang, May D.

    2016-01-01

    We propose a similarity measure based on the multivariate hypergeometric distribution for the pairwise comparison of images and data vectors. The formulation and performance of the proposed measure are compared with other similarity measures using synthetic data. A method of piecewise approximation is also implemented to facilitate application of the proposed measure to large samples. Example applications of the proposed similarity measure are presented using mass spectrometry imaging data and gene expression microarray data. Results from synthetic and biological data indicate that the proposed measure is capable of providing meaningful discrimination between samples, and that it can be a useful tool for identifying potentially related samples in large-scale biological data sets. PMID:24407308

  10. Thermal and Mechanical Buckling Analysis of Hypersonic Aircraft Hat-Stiffened Panels With Varying Face Sheet Geometry and Fiber Orientation

    NASA Technical Reports Server (NTRS)

    Ko, William L.

    1996-01-01

    Mechanical and thermal buckling behavior of monolithic and metal-matrix composite hat-stiffened panels were investigated. The panels have three types of face-sheet geometry: Flat face sheet, microdented face sheet, and microbulged face sheet. The metal-matrix composite panels have three types of face-sheet layups, each of which is combined with various types of hat composite layups. Finite-element method was used in the eigenvalue extractions for both mechanical and thermal buckling. The thermal buckling analysis required both eigenvalue and material property iterations. Graphical methods of the dual iterations are shown. The mechanical and thermal buckling strengths of the hat-stiffened panels with different face-sheet geometry are compared. It was found that by just microdenting or microbulging of the face sheet, the axial, shear, and thermal buckling strengths of both types of hat-stiffened panels could be enhanced considerably. This effect is more conspicuous for the monolithic panels. For the metal-matrix composite panels, the effect of fiber orientations on the panel buckling strengths was investigated in great detail, and various composite layup combinations offering, high panel buckling strengths are presented. The axial buckling strength of the metal-matrix panel was sensitive to the change of hat fiber orientation. However, the lateral, shear, and thermal buckling strengths were insensitive to the change of hat fiber orientation.

  11. Hats Off.

    ERIC Educational Resources Information Center

    Department of the Navy, Washington, DC.

    The materials in this lesson plan introduces students to the U.S. Navy by exploring the hats officers and enlisted personnel wear to work. The lesson is appropriate for students in grades 1-3 and was designed in accordance with local and national social studies standards. The lesson plan cites educational objectives and lists materials provided.…

  12. Helper Hats

    ERIC Educational Resources Information Center

    Ashbrook, Peggy

    2010-01-01

    Special clothing is worn by "community helpers" such as police officers, nurses, firefighters, cafeteria workers, dentists, and waste management workers as they do their jobs. The special clothing allows workers to be safe. Therefore, exploring how hats help community workers do their jobs can be a way to introduce the idea of how the shape or…

  13. On limit relations between some families of bivariate hypergeometric orthogonal polynomials

    NASA Astrophysics Data System (ADS)

    Area, I.; Godoy, E.

    2013-01-01

    In this paper we deal with limit relations between bivariate hypergeometric polynomials. We analyze the limit relation from trinomial distribution to bivariate Gaussian distribution, obtaining the limit transition from the second-order partial difference equation satisfied by bivariate hypergeometric Kravchuk polynomials to the second-order partial differential equation verified by bivariate hypergeometric Hermite polynomials. As a consequence the limit relation between both families of orthogonal polynomials is established. A similar analysis between bivariate Hahn and bivariate Appell orthogonal polynomials is also presented.

  14. A study of new hypergeometric transformations

    NASA Astrophysics Data System (ADS)

    Rathie, Arjun K.; Rakha, Medhat A.

    2008-11-01

    The aim of this research paper is to establish a quite general transformation involving hypergeometric functions by the method of elementary manipulation of the series representations. Certain known, as well as new hypergeometric transformations and identities not previously recorded in the literature, are then deduced by means of the generalized Kummer and Dixon theorems obtained earlier by Lavoie et al. An application of a newly obtained identity is also given.

  15. Atmospheric, Orbital and Secondary Eclipse Analysis of HAT-P-30-WASP-51b

    NASA Astrophysics Data System (ADS)

    Foster, Andrew S.; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Challener, Ryan; Foster, Austin James; Garland, Justin

    2016-01-01

    HAT-P-30-WASP-51b is a hot-Jupiter planet that orbits an F star every 2.8106 days at a distance of 0.0419 AU. Using the Spitzer Space Telescope in 2012 (Spitzer Program Number 70084) we observed two secondary eclipses of the planet, one in the 3.6 μm channel on 3 January and one in the 4.5 μm channel on 17 January. We present eclipse-depth measurements of 0.00163±0.0001 and 0.00146±0.00013 and we esitmate the infrared brightness temperatures to be 1900±50 and 1600±60 for these two channels, respectively, from an analysis using our Photometry for Orbits, Eclipses, and Transits (POET) pipeline. We also refine its orbit using our own secondary-eclipse measurements in combination with radial-velocity and transit observations from both professional and amateur observers. The most notable result from this orbital analysis is a detection of eccentricity in the planet's orbit. Using only the phase of our secondary eclipses, we can constrain ecosw to a minimum of 0.0084±0.0004, a 20 sigma detection of one component of the orbit's eccentricity that is independent of the effects that stellar tides have on radial velocity data. We then characterize its atmosphere's temperature- pressure profile and molecular abundances using our Bayesian Atmospheric Radiative Transfer code (BART). Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Sciences Fellowship.

  16. Test and Analysis of Composite Hat Stringer Pull-off Test Specimens

    NASA Technical Reports Server (NTRS)

    Li, Jian; OBrien, T. Kevin; Rousseau, Carl Q.

    1996-01-01

    Hat stringer pull-off tests were performed to evaluate the delamination failure mechanisms in the flange region for a rod-reinforced hat stringer section. A special test fixture was used to pull the hat off the stringer while reacting the pull-off load through roller supports at both stringer flanges. Microscopic examinations of the failed specimens revealed that failure occurred at the ply termination in the flange area where the flange of the stiffener is built up by adding 45/-45 tape plies on the top surface. Test results indicated that the as-manufactured microstructure in the flange region has a strong influence on the delamination initiation and the associated pull-off loads. Finite element models were created for each specimen with a detailed mesh based on micrographs of the critical location. A fracture mechanics approach and a mixed mode delamination criterion were used to predict the onset of delamination and the pull-off load. By modeling the critical local details of each specimen from micrographs, the model was able to accurately predict the hat stringer pull-off loads and replicate the variability in the test results.

  17. Hypergeometric states and their nonclassical properties

    NASA Astrophysics Data System (ADS)

    Fu, Hong-Chen; Sasaki, Ryu

    1997-05-01

    "Hypergeometric states," which are a one-parameter generalization of binomial states of the single-mode quantized radiation field, are introduced and their nonclassical properties are investigated. Their limits to the binomial states and to the coherent and number states are studied. The ladder operator formulation of the hypergeometric states is found and the algebra involved turns out to be a one-parameter deformation of su(2) algebra. These states exhibit highly nonclassical properties, like sub-Poissonian character, antibunching, and squeezing effects. The quasiprobability distributions in phase space, namely the Q and the Wigner functions are studied in detail. These remarkable properties seem to suggest that the hypergeometric states deserve further attention from theoretical and applicational sides of quantum optics.

  18. On some differential transformations of hypergeometric equations

    NASA Astrophysics Data System (ADS)

    Hounkonnou, M. N.; Ronveaux, A.

    2015-04-01

    Many algebraic transformations of the hypergeometric equation σ(x)z"(x) + τ(x)z'(x) + lz(x) = 0, where σ, τ, l are polynomial functions of degrees 2 (at most), 1, 0, respectively, are well known. Some of them involve x = x(t), a polynomial of degree r, in order to recover the Heun equation, extension of the hypergeometric equation by one more singularity. The case r = 2 was investigated by K. Kuiken (see 1979 SIAM J. Math. Anal. 10 (3) 655-657) and extended to r = 3,4, 5 by R. S. Maier (see 2005 J. Differ. Equat. 213 171 - 203). The transformations engendered by the function y(x) = A(x)z(x), also very popular in mathematics and physics, are used to get from the hypergeometric equation, for instance, the Schroedinger equation with appropriate potentials, as well as Heun and confluent Heun equations. This work addresses a generalization of Kimura's approach proposed in 1971, based on differential transformations of the hypergeometric equations involving y(x) = A(x)z(x) + B(x)z'(x). Appropriate choices of A(x) and B(x) permit to retrieve the Heun equations as well as equations for some exceptional polynomials. New relations are obtained for Laguerre and Hermite polynomials.

  19. Analysis of RNA-Seq Data Using TopHat and Cufflinks.

    PubMed

    Ghosh, Sreya; Chan, Chon-Kit Kenneth

    2016-01-01

    The recent advances in high throughput RNA sequencing (RNA-Seq) have generated huge amounts of data in a very short span of time for a single sample. These data have required the parallel advancement of computing tools to organize and interpret them meaningfully in terms of biological implications, at the same time using minimum computing resources to reduce computation costs. Here we describe the method of analyzing RNA-seq data using the set of open source software programs of the Tuxedo suite: TopHat and Cufflinks. TopHat is designed to align RNA-seq reads to a reference genome, while Cufflinks assembles these mapped reads into possible transcripts and then generates a final transcriptome assembly. Cufflinks also includes Cuffdiff, which accepts the reads assembled from two or more biological conditions and analyzes their differential expression of genes and transcripts, thus aiding in the investigation of their transcriptional and post transcriptional regulation under different conditions. We also describe the use of an accessory tool called CummeRbund, which processes the output files of Cuffdiff and gives an output of publication quality plots and figures of the user's choice. We demonstrate the effectiveness of the Tuxedo suite by analyzing RNA-Seq datasets of Arabidopsis thaliana root subjected to two different conditions. PMID:26519415

  20. A Bayesian analysis of HAT-P-7b using the EXONEST algorithm

    SciTech Connect

    Placek, Ben; Knuth, Kevin H.

    2015-01-13

    The study of exoplanets (planets orbiting other stars) is revolutionizing the way we view our universe. High-precision photometric data provided by the Kepler Space Telescope (Kepler) enables not only the detection of such planets, but also their characterization. This presents a unique opportunity to apply Bayesian methods to better characterize the multitude of previously confirmed exoplanets. This paper focuses on applying the EXONEST algorithm to characterize the transiting short-period-hot-Jupiter, HAT-P-7b (also referred to as Kepler-2b). EXONEST evaluates a suite of exoplanet photometric models by applying Bayesian Model Selection, which is implemented with the MultiNest algorithm. These models take into account planetary effects, such as reflected light and thermal emissions, as well as the effect of the planetary motion on the host star, such as Doppler beaming, or boosting, of light from the reflex motion of the host star, and photometric variations due to the planet-induced ellipsoidal shape of the host star. By calculating model evidences, one can determine which model best describes the observed data, thus identifying which effects dominate the planetary system. Presented are parameter estimates and model evidences for HAT-P-7b.

  1. ANALYSIS OF SPIN-ORBIT ALIGNMENT IN THE WASP-32, WASP-38, AND HAT-P-27/WASP-40 SYSTEMS

    SciTech Connect

    Brown, D. J. A.; Collier Cameron, A.; Enoch, B.; Miller, G. R. M.; Diaz, R. F.; Doyle, A. P.; Smalley, B.; Anderson, D. R.; Hellier, C.; Maxted, P. F. L.; Gillon, M.; Lendl, M.; Triaud, A. H. M. J.; Queloz, D.; Pollacco, D.; Boisse, I.; Hebrard, G.

    2012-12-01

    We present measurements of the spin-orbit alignment angle, {lambda}, for the hot Jupiter systems WASP-32, WASP-38, and HAT-P-27/WASP-40, based on data obtained using the HARPS spectrograph. We analyze the Rossiter-McLaughlin effect for all three systems and also carry out Doppler tomography for WASP-32 and WASP-38. We find that WASP-32 (T {sub eff} = 6140{sup +90} {sub -100} K) is aligned, with an alignment angle of {lambda} = 10.{sup 0}5{sup +6.4} {sub -6.5} obtained through tomography, and that WASP-38 (T {sub eff} = 6180{sup +40} {sub -60} K) is also aligned, with tomographic analysis yielding {lambda} = 7.{sup 0}5{sup +4.7} {sub -6.1}. The latter result provides an order-of-magnitude improvement in the uncertainty in {lambda} compared to the previous analysis of Simpson et al. We are only able to loosely constrain the angle for HAT-P-27/WASP-40 (T{sub eff} = 5190{sup +160} {sub -170} K) to {lambda} = 24.{sup 0}2{sup +76.0}{sub -44.5}, owing to the poor signal-to-noise ratio of our data. We consider this result a non-detection under a slightly updated version of the alignment test of Brown et al. We place our results in the context of the full sample of spin-orbit alignment measurements, finding that they provide further support for previously established trends.

  2. Hypergeometric type operators and their supersymmetric partners

    SciTech Connect

    Cotfas, Nicolae; Cotfas, Liviu Adrian

    2011-05-15

    The generalization of the factorization method performed by Mielnik [J. Math. Phys. 25, 3387 (1984)] opened new ways to generate exactly solvable potentials in quantum mechanics. We present an application of Mielnik's method to hypergeometric type operators. It is based on some solvable Riccati equations and leads to a unitary description of the quantum systems exactly solvable in terms of orthogonal polynomials or associated special functions.

  3. A Connection Formula for the q-Confluent Hypergeometric Function

    NASA Astrophysics Data System (ADS)

    Morita, Takeshi

    2013-07-01

    We show a connection formula for the q-confluent hypergeometric functions {}_2ϕ_1(a,b;0;q,x). Combining our connection formula with Zhang's connection formula for {}_2ϕ_0(a,b;-;q,x), we obtain the connection formula for the q-confluent hypergeometric equation in the matrix form. Also we obtain the connection formula of Kummer's confluent hypergeometric functions by taking the limit qto 1^{-} of our connection formula.

  4. Linear partial difference equations of hypergeometric type

    NASA Astrophysics Data System (ADS)

    Rodal, J.; Area, I.; Godoy, E.

    2007-03-01

    In this paper a systematic study of the orthogonal polynomial solutions of a second order partial difference equation of hypergeometric type of two variables is done. The Pearson's systems for the orthogonality weight of the solutions and also for the difference derivatives of the solutions are presented. The orthogonality property in subspaces is treated in detail, which leads to an analog of the Rodrigues-type formula for orthogonal polynomials of two discrete variables. A classification of the admissible equations as well as some examples related with bivariate Hahn, Kravchuk, Meixner, and Charlier families, and their algebraic and difference properties are explicitly given.

  5. Certain summation and transformation formulas for generalized hypergeometric series

    NASA Astrophysics Data System (ADS)

    Miller, Allen R.

    2009-09-01

    We derive summation formulas for generalized hypergeometric series of unit argument, one of which upon specialization reduces to Minton's summation theorem. As an application we deduce a reduction formula for a certain Kampé de Fériet function that in turn provides a Kummer-type transformation formula for the generalized hypergeometric function pFp(x).

  6. Sun protection with hats.

    PubMed

    Diffey, B L; Cheeseman, J

    1992-07-01

    The degree of sun protection provided by various styles of hat at different anatomical sites on the head was measured using model headforms and ultraviolet-sensitive film badges. It was found that hats with a small brim, such as the flat cap favoured by elderly male photosensitive patients, provided negligible protection at all sites apart from the vertex and forehead. Peaked baseball-style caps offer good protection to the nose but are relatively ineffective at other sites on the face. Hats with a wide (greater than 7.5 cm) brim are necessary in order to provide reasonable protection factors (greater than 3) around the nose and cheeks.

  7. The Hypergeometrical Universe: Cosmology and Standard Model

    NASA Astrophysics Data System (ADS)

    Pereira, Marco A.

    2010-12-01

    This paper presents a simple and purely geometrical Grand Unification Theory. Quantum Gravity, Electrostatic and Magnetic interactions are shown in a unified framework. Newton's, Gauss' and Biot-Savart's Laws are derived from first principles. Unification symmetry is defined for all the existing forces. This alternative model does not require Strong and Electroweak forces. A 4D Shock -Wave Hyperspherical topology is proposed for the Universe which together with a Quantum Lagrangian Principle and a Dilator based model for matter result in a quantized stepwise expansion for the whole Universe along a radial direction within a 4D spatial manifold. The Hypergeometrical Standard Model for matter, Universe Topology and a new Law of Gravitation are presented.

  8. The Hypergeometrical Universe: Cosmology and Standard Model

    SciTech Connect

    Pereira, Marco A.

    2010-12-22

    This paper presents a simple and purely geometrical Grand Unification Theory. Quantum Gravity, Electrostatic and Magnetic interactions are shown in a unified framework. Newton's, Gauss' and Biot-Savart's Laws are derived from first principles. Unification symmetry is defined for all the existing forces. This alternative model does not require Strong and Electroweak forces. A 4D Shock -Wave Hyperspherical topology is proposed for the Universe which together with a Quantum Lagrangian Principle and a Dilator based model for matter result in a quantized stepwise expansion for the whole Universe along a radial direction within a 4D spatial manifold. The Hypergeometrical Standard Model for matter, Universe Topology and a new Law of Gravitation are presented.

  9. Discrete Darboux transformation for discrete polynomials of hypergeometric type

    NASA Astrophysics Data System (ADS)

    Bangerezako, Gaspard

    1998-03-01

    The Darboux transformation, well known in second-order differential operator theory, is applied to the difference equations satisfied by the discrete hypergeometric polynomials (Charlier, Meixner-Kravchuk, Hahn).

  10. Comparative Analysis of the Recently Discovered hAT Transposon TcBuster in Human Cells

    PubMed Central

    Woodard, Lauren E.; Li, Xianghong; Malani, Nirav; Kaja, Aparna; Hice, Robert H.; Atkinson, Peter W.; Bushman, Frederic D.; Craig, Nancy L.; Wilson, Matthew H.

    2012-01-01

    Background Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in previous studies in insect embryoes. Methodology/Principal Findings We tested TcBuster for its activity in human embryonic kidney 293 (HEK-293) cells. Excision footprints obtained from HEK-293 cells contained small insertions and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous end-joining. Genome-wide analysis of 23,417 piggyBac, 30,303 Sleeping Beauty, and 27,985 TcBuster integrations in HEK-293 cells revealed a uniquely different integration pattern when compared to other transposon systems with regards to genomic elements. TcBuster experimental conditions were optimized to assay TcBuster activity in HEK-293 cells by colony assay selection for a neomycin-containing transposon. Increasing transposon plasmid increased the number of colonies, whereas gene transfer activity dependent on codon-optimized transposase plasmid peaked at 100 ng with decreased colonies at the highest doses of transposase DNA. Expression of the related human proteins Buster1, Buster3, and SCAND3 in HEK-293 cells did not result in genomic integration of the TcBuster transposon. TcBuster, Tol2, and piggyBac were compared directly at different ratios of transposon to transposase and found to be approximately comparable while having their own ratio preferences. Conclusions/Significance TcBuster was found to be highly active in mammalian HEK-293 cells and represents a promising tool for mammalian genome engineering. PMID:23166581

  11. Using the Hypergeometric Model to analyze the buckling of drillstrings in curved boreholes

    SciTech Connect

    Sampaio, J.H.B. Jr.; Eustes, A.W. III

    1998-12-31

    Current methodologies for analytically determining the onset of buckling of drillstrings within curved boreholes are limited. In this paper, the Hypergeometric Model is shown to be an effective model to determine drillstring buckling within curved boreholes. With the Hypergeometric Model, the analysis of drillstring buckling results in curves expressing the local buckling force versus the angle of inclination. The local buckling force alone, however, does not contain all the information required for a practical analysis. From the local buckling force curve, the positional buckling force is derived. The positional buckling force considers the distributed weight of the drillstring and the friction between the drillstring and the borehole wall. From this curve, the point of minimum resistance to buckling of the drillstring is determined. Using the local and positional buckling force curves, experimental results and simulations are presented. When multiple configurations exist (for example tapered drillstrings, tapered boreholes, multi-curved boreholes, or any combination of these), the analysis procedure uses superposition of two or more single configuration curves and a graphical algorithm. The Hypergeometric Model permits the optimization of the position of the crossing points (cross-over positioning, casing-shoe positioning, and change of curvature) to achieve extended reach with less risk and cost. The procedure for this model and examples are presented in this paper.

  12. Program Transformation in HATS

    SciTech Connect

    Winter, V.L.

    1999-02-24

    HATS is a general purpose syntax derivation tree based transformation system in which transformation sequences are described in special purpose language. A powerful feature of this language is that unification is an explicit operation. By making unification explicit, an elegant framework arises in which to express complex application conditions which in turn enables refined control strategies to be realized. This paper gives an overview of HATS, focusing especially on the framework provided by the transformation language and its potential with respect to control and general purpose transformation.

  13. Auto-focusing accelerating hyper-geometric laser beams

    NASA Astrophysics Data System (ADS)

    Kovalev, A. A.; Kotlyar, V. V.; Porfirev, A. P.

    2016-02-01

    We derive a new solution to the paraxial wave equation that defines a two-parameter family of three-dimensional structurally stable vortex annular auto-focusing hyper-geometric (AH) beams, with their complex amplitude expressed via a degenerate hyper-geometric function. The AH beams are found to carry an orbital angular momentum and be auto-focusing, propagating on an accelerating path toward a focus, where the annular intensity pattern is ‘sharply’ reduced in diameter. An explicit expression for the complex amplitude of vortex annular auto-focusing hyper-geometric-Gaussian beams is derived. The experiment has been shown to be in good agreement with theory.

  14. Distinguishing between Binomial, Hypergeometric and Negative Binomial Distributions

    ERIC Educational Resources Information Center

    Wroughton, Jacqueline; Cole, Tarah

    2013-01-01

    Recognizing the differences between three discrete distributions (Binomial, Hypergeometric and Negative Binomial) can be challenging for students. We present an activity designed to help students differentiate among these distributions. In addition, we present assessment results in the form of pre- and post-tests that were designed to assess the…

  15. Differential inequalities imposed by the extended hypergeometric function.

    PubMed

    Ibrahim, Rabha W; Ahmad, M Z; Al-Janaby, Hiba F

    2016-01-01

    Recently, the generalized hypergeometric function is extended by utilizing the Beta function. Based on this type of function, we introduce a new operator in the open unit disk. The present article investigates some subordination and superordination results for certain normalized analytic functions in the open unit disk, which are acted upon by the generalized Noor integral operator. Some of outcomes improve and generalize previously known outcomes.

  16. Classification of hypergeometric identities for pi and other logarithms of algebraic numbers.

    PubMed

    Chudnovsky, D V; Chudnovsky, G V

    1998-03-17

    This paper provides transcendental and algebraic framework for the classification of identities expressing pi and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and their values are analyzed. The existing identities are explained, and new exhaustive classes of new ones are presented.

  17. Classification of hypergeometric identities for π and other logarithms of algebraic numbers

    PubMed Central

    Chudnovsky, D. V.; Chudnovsky, G. V.

    1998-01-01

    This paper provides transcendental and algebraic framework for the classification of identities expressing π and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and their values are analyzed. The existing identities are explained, and new exhaustive classes of new ones are presented. PMID:9501160

  18. Hypergeometric Forms for Ising-Class Integrals

    SciTech Connect

    Bailey, David H.; Borwein, David; Borwein, Jonathan M.; Crandall,Richard E.

    2006-07-01

    We apply experimental-mathematical principles to analyzecertain integrals relevant to the Ising theory of solid-state physics. Wefind representations of the these integrals in terms of MeijerG-functions and nested-Barnes integrals. Our investigations began bycomputing 500-digit numerical values of Cn,k,namely a 2-D array of Isingintegrals for all integers n, k where n is in [2,12]and k is in [0,25].We found that some Cn,k enjoy exact evaluations involving DirichletL-functions or the Riemann zeta function. In theprocess of analyzinghypergeometric representations, we found -- experimentally and strikingly-- that the Cn,k almost certainly satisfy certain inter-indicialrelations including discrete k-recursions. Using generating functions,differential theory, complex analysis, and Wilf-Zeilberger algorithms weare able to prove some central cases of these relations.

  19. 30 CFR 56.15002 - Hard hats.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Hard hats. 56.15002 Section 56.15002 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Personal Protection § 56.15002 Hard hats. All persons shall wear suitable hard hats when in or around a mine or plant where falling...

  20. 30 CFR 57.15002 - Hard hats.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Hard hats. 57.15002 Section 57.15002 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Underground § 57.15002 Hard hats. All persons shall wear suitable hard hats when in or around a mine or...

  1. The HAT-P-7 and HAT-P-11 Star-Planet Systems

    NASA Astrophysics Data System (ADS)

    Medina, Jennifer; Manrique, Maria; van Hamme, Walter

    2016-03-01

    Radial velocities and KEPLER light curves of the transiting exoplanets HAT-P-7b and HAT-P-11b are analyzed using a general binary star model. The HAT-P-7 system has been a subject of interest due to the irregular orbit of the HAT-P-7b exoplanet with respect to its parent star. HAT-P-7b's orbit has shed light on the diversity of systems that exist in our observable Universe. HAT-P-11 hosts a K type variable star which we were able to analyze with a fourier fit on the light curve data. It is also a host to exoplanet HAT-P-11b which has a slightly inclined orbit. Using our own software, we have calculated the parameters for star-planet pair of HAT-P-7 and HAT-P-11. This presents another way for astronomers to study these complex systems.

  2. Confluent hypergeometric functions and two variables Laguerre polynomials as a solutions of Wilczynski type system

    NASA Astrophysics Data System (ADS)

    Tasmambetov, Zhaxylyk

    2016-08-01

    In this work, it is considered the system of Wilczynski type, and from this system it is defined a range of systems having the solutions in the form of confluent hypergeometric functions and two variables Laguerre polynomials. It is shown that two variables confluent hypergeometric functions being the main tool of investigation of Laguerre polynomials and two variables Whittaker functions. This aspects still remaining little-investigated.

  3. Euler-type transformations for the generalized hypergeometric function r+2 F r+1( x)

    NASA Astrophysics Data System (ADS)

    Miller, A. R.; Paris, R. B.

    2011-02-01

    We provide generalizations of two of Euler's classical transformation formulas for the Gauss hypergeometric function extended to the case of the generalized hypergeometric function r+2 F r+1( x) when there are additional numeratorial and denominatorial parameters differing by unity. The method employed to deduce the latter is also implemented to obtain a Kummer-type transformation formula for r+1 F r+1 ( x) that was recently derived in a different way.

  4. Household wireless electroencephalogram hat

    NASA Astrophysics Data System (ADS)

    Szu, Harold; Hsu, Charles; Moon, Gyu; Yamakawa, Takeshi; Tran, Binh

    2012-06-01

    We applied Compressive Sensing to design an affordable, convenient Brain Machine Interface (BMI) measuring the high spatial density, and real-time process of Electroencephalogram (EEG) brainwaves by a Smartphone. It is useful for therapeutic and mental health monitoring, learning disability biofeedback, handicap interfaces, and war gaming. Its spec is adequate for a biomedical laboratory, without the cables hanging over the head and tethered to a fixed computer terminal. Our improved the intrinsic signal to noise ratio (SNR) by using the non-uniform placement of the measuring electrodes to create the proximity of measurement to the source effect. We computing a spatiotemporal average the larger magnitude of EEG data centers in 0.3 second taking on tethered laboratory data, using fuzzy logic, and computing the inside brainwave sources, by Independent Component Analysis (ICA). Consequently, we can overlay them together by non-uniform electrode distribution enhancing the signal noise ratio and therefore the degree of sparseness by threshold. We overcame the conflicting requirements between a high spatial electrode density and precise temporal resolution (beyond Event Related Potential (ERP) P300 brainwave at 0.3 sec), and Smartphone wireless bottleneck of spatiotemporal throughput rate. Our main contribution in this paper is the quality and the speed of iterative compressed image recovery algorithm based on a Block Sparse Code (Baranuick et al, IEEE/IT 2008). As a result, we achieved real-time wireless dynamic measurement of EEG brainwaves, matching well with traditionally tethered high density EEG.

  5. A Three Corner Hat-based analysis of station position time series for the assessment of inter-technique precision at ITRF co-located sites

    NASA Astrophysics Data System (ADS)

    Abbondanza, C.; Chin, T. M.; Gross, R. S.; Heflin, M. B.; Hurst, K. J.; Parker, J. W.; Wu, X.; Altamimi, Z.

    2012-12-01

    Assessing the uncertainty in geodetic positioning is a crucial factor when combining independent space-geodetic solutions for the computation of the International Terrestrial Reference Frame (ITRF). ITRF is a combined product based on the stacking of VLBI, GPS, SLR and DORIS solutions and merging the single technique reference frames with terrestrial local tie measurements at co-located sites. In current ITRF realizations, the uncertainty evaluation of the four techniques relies on the analysis of the post-fit residuals, which are a by-product of the combination process. An alternative approach to the assessment of the inter-technique precision can be offered by a Three Corner Hat (TCH) analysis of the non-linear residual time series obtained at ITRF co-location sites as a by-product of the stacking procedure. Non-linear residuals of station position time series stemming from global networks of the four techniques can be modeled as a composition of periodic signals (commonly annual and semi-annual) and stochastic noise, typically characterized as a combination of flicker and white noise. Pair-wise differences of station position time series of at least three co-located instruments can be formed with the aim of removing the common geophysical signal and characterizing the inter-technique precision. The application of TCH relies on the hypothesis of absence of correlation between the error processes of the four techniques and assumes the stochastic noise to be Gaussian. If the hypothesis of statistical independence between the space-geodetic technique errors is amply verified, the assumption of pure white noise of the stochastic error processes appears to be more questionable. In fact, previous studies focused on geodetic positioning consistently showed that flicker noise generally prevails over white noise in the analysis of global network GPS time series, whereas in VLBI, SLR and DORIS time series Gaussian noise is predominant. In this investigation, TCH is applied

  6. Histone acetyltransferase HAT4 modulates navigation across G2/M and re-entry into G1 in Leishmania donovani

    PubMed Central

    Yadav, Aarti; Chandra, Udita; Saha, Swati

    2016-01-01

    Histone acetyltransferases impact multiple processes. This study investigates the role of histone acetyltransferase HAT4 in Leishmania donovani. Though HAT4 was dispensable for survival, its elimination decreased cell viability and caused cell cycle defects, with HAT4-nulls experiencing an unusually long G2/M. Survival of HAT4-nulls in macrophages was also substantially compromised. DNA microarray analysis revealed that HAT4 modestly regulated the expression of only a select number of genes, thus not being a major modulator of global gene expression. Significantly, cdc20 was among the downregulated genes. To ascertain if decreased expression of cdc20 was responsible for HAT4-null growth and cell cycle defects we expressed LdCdc20 ectopically in HAT4-nulls. We found this to alleviate the aberrant growth and cell cycle progression patterns displayed by HAT4-nulls, with cells navigating G2/M phase and re-entering G1 phase smoothly. HAT4-nulls expressing LdCdc20 ectopically showed survival rates comparable to wild type within macrophages, suggesting that G2/M defects were responsible for poor survival of HAT4-nulls within host cells also. These are the first data analyzing the in vivo functional role of HAT4 in any trypanosomatid. Our results directly demonstrate for the first time a role for Cdc20 in regulating trypanosomatid G2/M events, opening avenues for further research in this area. PMID:27272906

  7. HYPERDIRE-HYPERgeometric functions DIfferential REduction: Mathematica-based packages for the differential reduction of generalized hypergeometric functions: Lauricella function FC of three variables

    NASA Astrophysics Data System (ADS)

    Bytev, Vladimir V.; Kniehl, Bernd A.

    2016-09-01

    We present a further extension of the HYPERDIRE project, which is devoted to the creation of a set of Mathematica-based program packages for manipulations with Horn-type hypergeometric functions on the basis of differential equations. Specifically, we present the implementation of the differential reduction for the Lauricella function FC of three variables.

  8. HYPERSAMP - HYPERGEOMETRIC ATTRIBUTE SAMPLING SYSTEM BASED ON RISK AND FRACTION DEFECTIVE

    NASA Technical Reports Server (NTRS)

    De, Salvo L. J.

    1994-01-01

    HYPERSAMP is a demonstration of an attribute sampling system developed to determine the minimum sample size required for any preselected value for consumer's risk and fraction of nonconforming. This statistical method can be used in place of MIL-STD-105E sampling plans when a minimum sample size is desirable, such as when tests are destructive or expensive. HYPERSAMP utilizes the Hypergeometric Distribution and can be used for any fraction nonconforming. The program employs an iterative technique that circumvents the obstacle presented by the factorial of a non-whole number. HYPERSAMP provides the required Hypergeometric sample size for any equivalent real number of nonconformances in the lot or batch under evaluation. Many currently used sampling systems, such as the MIL-STD-105E, utilize the Binomial or the Poisson equations as an estimate of the Hypergeometric when performing inspection by attributes. However, this is primarily because of the difficulty in calculation of the factorials required by the Hypergeometric. Sampling plans based on the Binomial or Poisson equations will result in the maximum sample size possible with the Hypergeometric. The difference in the sample sizes between the Poisson or Binomial and the Hypergeometric can be significant. For example, a lot size of 400 devices with an error rate of 1.0% and a confidence of 99% would require a sample size of 400 (all units would need to be inspected) for the Binomial sampling plan and only 273 for a Hypergeometric sampling plan. The Hypergeometric results in a savings of 127 units, a significant reduction in the required sample size. HYPERSAMP is a demonstration program and is limited to sampling plans with zero defectives in the sample (acceptance number of zero). Since it is only a demonstration program, the sample size determination is limited to sample sizes of 1500 or less. The Hypergeometric Attribute Sampling System demonstration code is a spreadsheet program written for IBM PC compatible

  9. Top-hat random fiber Bragg grating.

    PubMed

    Yin, Hongwei; Gbadebo, Adenowo; Turitsyna, Elena G

    2015-08-01

    We examined the possibility of using noise or pseudo-random variations of the refractive index in the design of fiber Bragg gratings (FBGs). We demonstrated theoretically and experimentally that top-hat FBGs may be designed and fabricated using this approach. The reflectivity of the fabricated top-hat FBG matches quite well with that of the designed one. PMID:26258365

  10. Nonlinear interaction of intense hypergeometric Gaussian subfamily laser beams in plasma

    NASA Astrophysics Data System (ADS)

    Sobhani, H.; Vaziri (Khamedi), M.; Rooholamininejad, H.; Bahrampour, A. R.

    2016-07-01

    Propagation of Hypergeometric-Gaussian laser beam in a nonlinear plasma medium is investigated by considering the Source Dependent Expansion method. A subfamily of Hypergeometric-Gaussian beams with a non-negative, even and integer radial index, can be expressed as the linear superposition of finite number of Laguerre-Gaussian functions. Propagation of Hypergeometric-Gaussian beams in a nonlinear plasma medium depends on the value of radial index. The bright rings' number of these beams is changed during the propagation in plasma medium. The effect of beam vortex charge number l and initial (input) beam intensity on the self-focusing of Hypergeometric-Gaussian beams is explored. Also, by choosing the suitable initial conditions, Hypergeometric-Gaussian subfamily beams can be converted to one or more mode components that a typical of mode conversion may be occurred. The self-focusing of these winding beams can be used to control the focusing force and improve the electron bunch quality in laser plasma accelerators.

  11. Some families of generating functions and associated hypergeometric transformation and reduction formulas

    NASA Astrophysics Data System (ADS)

    Srivastava, H. M.

    2016-07-01

    Summation, transformation and reduction formulas for various families of hypergeometric functions in one, two and more variables are potentially useful in many diverse areas of applications. The main object of this paper is to derive several substantially more general results on this subject than those considered recently by Neethu et al. [7] in connection with Bailey's transformation involving the Gauss hypergeometrc function 2 F 1 (see [1]). The methodology used here is based essentially on some families of hypergeometric generating functions. Relevant connections of the results presented in this paper with those in the earlier works are also pointed out.

  12. Triality in SU(2) Seiberg-Witten theory and Gauss hypergeometric function

    NASA Astrophysics Data System (ADS)

    Tai, Ta-Sheng

    2010-11-01

    Through Alday-Gaiotto-Tachikawa conjecture, we show how triality observed in N=2 SU(2) Nf=4 QCD can be interpreted geometrically as the interplay among six of Kummer’s 24 solutions belonging to one fixed Riemann scheme in the context of hypergeometric differential equations.

  13. Dialing the Love Number of Hot Jupiter HAT-P-13b

    NASA Astrophysics Data System (ADS)

    Buhler, Peter

    2015-05-01

    HAT-P-13b is Jupiter-mass transiting planet in a 0.04 AU orbit around its host star. It has an outer companion, HAT-P-13c, with a minimum mass of 14.7 MJup in a highly eccentric 1.2 AU orbit. These two companions form an isolated dynamical system with their host star [1]. The nature of this system allows the two bodies to settle into a fixed eccentricity state where the eccentricity of HAT-P-13b is directly related to its oblateness as described by the Love number, k2 [2]. In order to constrain the eccentricity, and therefore k2, of HAT-P-13b, we use the Spitzer Space Telescope to measure the timing of its secondary eclipses at 3.6 and 4.5 μm. We then simultaneously fit our secondary eclipse data in conjunction with previously measured radial velocity and transit data. Finally, we apply the fact that, if the orbits of HAT-P-13b and HAT-P-13c are coplanar, then their apsides are aligned [3]. The apsidal orientation of HAT-P-13c is much better constrained because of its high eccentricity, which helps break the degeneracy between the eccentricity and apsidal orientation in interpreting the measured secondary eclipse time. Our analysis allows us to measure the eccentricity of HAT-P-13b’s orbit with a precision approximately ten times better than that of previously published values, in the coplanar case, and allows us to place the first meaningful constraints on the core mass of HAT-P-13b.[1] Becker & Batygin 2013, ApJ 778, 100 [2] Wu & Goldreich 2002, ApJ 564, 1024 [3] Batygin+ 2009, ApJ 704, L49

  14. Exoplanet HAT-P-11b Secondary Transit Observations

    NASA Technical Reports Server (NTRS)

    Barry, Richard K., Jr.

    2010-01-01

    We have conducted secondary eclipse observations of exoplanet HAT--11b, recently discovered by proposal G. Bakos and his colleagues. HAT-P-11b is the smallest transiting extrasolar planet yet found and one of only two known exo-Neptunes. We have observed the system at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Once the secondary eclipse is located through analysis of the data, we will make a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-1lb has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi major axis 0.053 AU. Measurements of the secondary eclipse will clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. A precise determination of the orbit phase for the secondary eclipse will also be of great utility for Kepler observations of this system at visible wavelengths.

  15. Nonperiodic echoes from mushroom billiard hats

    NASA Astrophysics Data System (ADS)

    Dietz, B.; Friedrich, T.; Miski-Oglu, M.; Richter, A.; Seligman, T. H.; Zapfe, K.

    2006-11-01

    Mushroom billiards have the remarkable property to show one or more clear cut integrable islands in one or several chaotic seas, without any fractal boundaries. The islands correspond to orbits confined to the hats of the mushrooms, which they share with the chaotic orbits. It is thus interesting to ask how long a chaotic orbit will remain in the hat before returning to the stem. This question is equivalent to the inquiry about delay times for scattering from the hat of the mushroom into an opening where the stem should be. For fixed angular momentum we find that no more than three different delay times are possible. This induces striking nonperiodic structures in the delay times that may be of importance for mesoscopic devices and should be accessible to microwave experiments.

  16. Error bars for three-cornered hats.

    PubMed

    Ekstrom, Christopher R; Koppang, Paul A

    2006-05-01

    Abstract-The three-cornered hat is a procedure for extracting the stabilities of three clocks when the only available data is the time or frequency differences between the clocks. To our knowledge, there has been no method of determining a confidence interval for such a stability estimate. In this paper, we present a method for determining the number of degrees of freedom of the estimate, which allows the assignment of a confidence interval to a three-cornered hat stability estimate. We also investigate using the total variance and biases involved.

  17. The Atmospheric Circulation of Eccentric Hot Jupiter HAT-P-2b

    NASA Astrophysics Data System (ADS)

    Lewis, Nikole; Knutson, H.; Showman, A. P.; Fortney, J. J.; Agol, E.; Burrows, A.; Charbonneau, D.; Cowan, N. B.; Deming, D.; Desert, J.; Langton, J.; Laughlin, G.; Mighell, K.

    2011-09-01

    The Spitzer warm mission has already greatly expanded the field of exoplanet characterization with over 3000 hours of time dedicated to exoplanet observations. Observations of eclipsing systems with Spitzer are at the heart of these advances, as they allow us to move beyond simple mass and period estimates to determine planetary radius, dayside emission, and emission variations as a function of orbital phase. The eclipsing system HAT-P-2 is of special interest because the massive Jovian sized planet in this system is on a highly eccentric orbit (e=0.5171). Because HAT-P-2b's orbit is eccentric, the planet is subject to time variable heating and probable non-synchronous rotation. Circulation patterns that we expect to develop in HAT-P-2b's atmosphere will likely vary with both planetary local time and orbital phase. Here we present an analysis of two full-orbit light curves for the HAT-P-2 system obtained at 3.6 and 4.5 microns during the first two years of the Spitzer warm mission and discuss the observational constraints imposed on the atmospheric circulation of HAT-P-2b. Additionally, three-dimensional atmospheric models that incorporate realistic radiative transfer will be presented to further elucidate possible global scale circulations patterns present in the atmosphere of HAT-P-2b. Support for this work was provided by NASA.

  18. The exact equation of motion of a simple pendulum of arbitrary amplitude: a hypergeometric approach

    NASA Astrophysics Data System (ADS)

    Qureshi, M. I.; Rafat, M.; Ismail Azad, S.

    2010-11-01

    The motion of a simple pendulum of arbitrary amplitude is usually treated by approximate methods. By using generalized hypergeometric functions, it is however possible to solve the problem exactly. In this paper, we provide the exact equation of motion of a simple pendulum of arbitrary amplitude. A new and exact expression for the time of swinging of a simple pendulum from the vertical position to an arbitrary angular position θ is given by equation (3.10). The time period of such a pendulum is also exactly expressible in terms of hypergeometric functions. The exact expressions thus obtained are used to plot the graphs that compare the exact time period T(θ0) with the time period T(0) (based on simple harmonic approximation). We also compare the relative difference between T(0) and T(θ0) found from the exact equation of motion with the usual perturbation theory estimate. The treatment is intended for graduate students, who have acquired some familiarity with the hypergeometric functions. This approach may also be profitably used by specialists who encounter during their investigations nonlinear differential equations similar in form to the pendulum equation. Such nonlinear differential equations could arise in diverse fields, such as acoustic vibrations, oscillations in small molecules, turbulence and electronic filters, among others.

  19. James J. Gallagher: Man in the White Hat

    ERIC Educational Resources Information Center

    Jolly, Jennifer L.; Robinson, Ann

    2014-01-01

    In classic Western movies, the good guy could be frequently identified by his trademark white Stetson hat, whereas the bad guy always wore black. James J. Gallagher wore many hats during his career that spanned over six decades; he too would be known as the "man in the white hat,"--trusted to do the right thing. From 1967 to 1970,…

  20. Role of Transcription Factor HAT1 in Modulating Arabidopsis thaliana Response to Cucumber mosaic virus.

    PubMed

    Zou, Li-Juan; Deng, Xing-Guang; Han, Xue-Ying; Tan, Wen-Rong; Zhu, Li-Jun; Xi, De-Hui; Zhang, Da-Wei; Lin, Hong-Hui

    2016-09-01

    Arabidopsis thaliana homeodomain-leucine zipper protein 1 (HAT1) belongs to the homeodomain-leucine zipper (HD-Zip) family class II that plays important roles in plant growth and development as a transcription factor. To elucidate further the role of HD-Zip II transcription factors in plant defense, the A. thaliana hat1, hat1hat3 and hat1hat2hat3 mutants and HAT1 overexpression plants (HAT1OX) were challenged with Cucumber mosaic virus (CMV). HAT1OX displayed more susceptibility, while loss-of-function mutants of HAT1 exhibited less susceptibility to CMV infection. HAT1 and its close homologs HAT2 and HAT3 function redundantly, as the triple mutant hat1hat2hat3 displayed increased virus resistance compared with the hat1 and hat1hat3 mutants. Furthermore, the induction of the antioxidant system (the activities and expression of enzymatic antioxidants) and the expression of defense-associated genes were down-regulated in HAT1OX but up-regulated in hat1hat2hat3 when compared with Col-0 after CMV infection. Further evidence showed that the involvement of HAT1 in the anti-CMV defense response might be dependent on salicylic acid (SA) but not jasmonic acid (JA). The SA level or expression of SA synthesis-related genes was decreased in HAT1OX but increased in hat1hat2hat3 compared with Col-0 after CMV infection, but there were little difference in JA level or JA synthesis-related gene expression among HAT1OX or defective plants. In addition, HAT1 expression is dependent on SA accumulation. Taken together, our study indicated that HAT1 negatively regulates plant defense responses to CMV. PMID:27328697

  1. Clinical trials update from the American College of Cardiology 2008: CARISMA, TRENDS, meta-analysis of Cox-2 studies, HAT, ON-TARGET, HYVET, ACCOMPLISH, MOMENTUM, PROTECT, HORIZON-HF and REVERSE.

    PubMed

    Cleland, John G F; Coletta, Alison P; Yassin, Ashraf; Hado, Hussien; Cullington, Damien; Abdellah, Ahmed Tageldien; Clark, Andrew L

    2008-06-01

    This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the American College of Cardiology. Unpublished reports should be considered as preliminary data, as analyses may change in the final publication. CARISMA investigated the use of implantable loop recorders for detecting life-threatening arrhythmias in patients with LVSD after MI and found that brady- and ventricular tachy-arrhythmias predicted an adverse prognosis. The TRENDS study showed that the burden of atrial fibrillation detected by pacemakers or defibrillators predicted the risk of embolic events but not with sufficient precision to justify changes in anti-thrombotic management. A meta-analysis of six trials reported an increased cardiovascular risk associated with celecoxib, particularly for heart failure, which was related to dose and baseline cardiovascular risk. The HAT study failed to show a benefit of providing post-MI patients with a home defibrillator. MOMENTUM, a study of a device designed to augment aortic blood flow, was stopped early due to increased bleeding risk. Results from PROTECT support the use of rolofylline 30 mg/day in acute heart failure, a definitive study is now underway. Istaroxime, an agent that appears to have both inotropic and lusitropic effects, improved haemodynamics when added to standard therapy in patients stabilised after admission with heart failure in HORIZON-HF. The REVERSE study suggested that CRT improves ventricular function and reduces morbidity even in patients with few or no symptoms of heart failure and may delay or prevent worsening heart failure.

  2. A closed form of a kurtosis parameter of a hypergeometric-Gaussian type-II beam

    NASA Astrophysics Data System (ADS)

    F, Khannous; A, A. A. Ebrahim; A, Belafhal

    2016-04-01

    Based on the irradiance moment definition and the analytical expression of waveform propagation for hypergeometric-Gaussian type-II beams passing through an ABCD system, the kurtosis parameter is derived analytically and illustrated numerically. The kurtosis parameters of the Gaussian beam, modified Bessel modulated Gaussian beam with quadrature radial and elegant Laguerre–Gaussian beams are obtained by treating them as special cases of the present treatment. The obtained results show that the kurtosis parameter depends on the change of the beam order m and the hollowness parameter p, such as its decrease with increasing m and increase with increasing p.

  3. [Usefulness of top-hat transform processing in whole body bone scintigraphy].

    PubMed

    Kita, Akinobu; Sugimoto, Katsuya; Tsuchida, Tatsurou; Kishimoto, Takahiro; Toi, Akiko; Shimada, Masato; Adachi, Toshiki

    2013-01-01

    To assess the usefulness of top-hat transform processing in whole body bone scintigraphy, five radiological technicians interpreted both original and top-hat processed images to determine the improvement of lesion detectability and interpretation time. For the evaluation of detectability, receiver operating characteristic (ROC) analysis was performed. The area under the curve (AUC) calculated from the ROC curve was improved in all observers (from 0.786 to 0.864 in average), although no significant difference was observed. However, the interpretation time was improved significantly (from 24.5 to 16.2 s in average). Top-hat transform processing in whole body bone scintigraphy is thought to be useful for the improvement of lesion detectability and interpretation time.

  4. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    SciTech Connect

    1997-06-01

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy`s (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. This LSTP describes the long-term surveillance program the DOE will implement to ensure the Mexican Hat disposal site performs as designed and is cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed for custody and long-term care, the Nuclear Regulatory Commission (NRC) requires the DOE to submit such a site-specific LTSP.

  5. A special asymptotic limit of a Kampé de Fériet hypergeometric function appearing in nonhomogeneous Coulomb problems

    NASA Astrophysics Data System (ADS)

    Ancarani, L. U.; Gasaneo, G.

    2011-02-01

    In the investigation of two-body Coulomb Schrödinger equations with some types of nonhomogeneities, the particular solution can be expressed in terms of a two-variable Kampé de Fériet hypergeometric function. The asymptotic limit of the latter—for both variables being large but their ratio being a bound constant—is required in order to extract relevant physical information from the solutions. In this report the mathematical limit is provided. For that purpose, a particular series representation of the hypergeometric function—in terms of products of Kummer and Gauss functions—is first derived.

  6. Multivariate hypergeometric cascades, isomonodromy problems and Ward ansätze

    NASA Astrophysics Data System (ADS)

    Shah, M. R.; Woodhouse, N. M. J.

    2010-10-01

    The Ward ansätze in twistor theory generate solutions of the SL(2,\\m{C}) anti-self-dual Yang-Mills equations from solutions of the wave equation in spacetime. The theory has a straightforward generalization in which the 'spacetime' is an open set in the Grassmannian Gr(2, N). The linear 'wave equation' in this case has special solutions, called the generalized confluent hypergeometric functions, which are equivariant under the natural action of Jordan groups on spacetime. Using the generalized Penrose-Ward transform, Ward ansätze of increasing weight arising from such hypergeometric functions give a cascade of solutions to isomonodromy problems for systems of ordinary differential equations, generally with irregular singularities. The extended construction is explored in detail, and two examples are given. In the first, solutions of the Schlesinger equations are constructed from the Lauricella FD functions; in the second, solutions of the isomonodromy problem for systems with two double poles and any number of simple poles are obtained from the generalized Bessel functions.

  7. A Bayesian Atmospheric Retrieval Performed on HAT-P-16b and WASP-11b/HAT-P-10b

    NASA Astrophysics Data System (ADS)

    McIntyre, Kathleen J.; Harrington, Joseph; Challener, Ryan C.; Hardin, Matthew Ryan; Bowman, Oliver Oliver; Foster, Andrew S. D.; Lenius, Maria; Hartman, Joel D.; Bakos, Gaspar; Blecic, Jasmina; Cubillos, Patricio; Ariston Hardy, Ryan; Cameron, Andrew

    2016-10-01

    HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). WASP-11b/HAT-P-10b is a cooler (1020 ± 17 K), 0.487 ± 0.018 Jupiter-mass exoplanet orbiting a K3 star every 3.7224747 ± 0.0000065 days (Bakos et al. 2009, co-discovered by West et al. 2008). We observed secondary eclipses of both planets using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the two planets. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  8. The Mexican hat effect on the delamination buckling of a compressed thin film

    NASA Astrophysics Data System (ADS)

    Zhang, Yin; Liu, Yun

    2014-12-01

    Because of the interaction between film and substrate, the film buckling stress can vary significantly, depending on the delamination geometry, the film and substrate mechanical properties. The Mexican hat effect indicates such interaction. An analytical method is presented, and related dimensional analysis shows that a single dimensionless parameter can effectively evaluate the effect.

  9. Flexural fatigue life prediction of closed hat-section using materially nonlinear axial fatigue characteristics

    NASA Technical Reports Server (NTRS)

    Razzaq, Zia

    1989-01-01

    Straight or curved hat-section members are often used as structural stiffeners in aircraft. For instance, they are employed as stiffeners for the dorsal skin as well as in the aerial refueling adjacent area structure in F-106 aircraft. The flanges of the hat-section are connected to the aircraft skin. Thus, the portion of the skin closing the hat-section interacts with the section itself when resisting the stresses due to service loads. The flexural fatigue life of such a closed section is estimated using materially nonlinear axial fatigue characteristics. It should be recognized that when a structural shape is subjected to bending, the fatigue life at the neutral axis is infinity since the normal stresses are zero at that location. Conversely, the fatigue life at the extreme fibers where the normal bending stresses are maximum can be expected to be finite. Thus, different fatigue life estimates can be visualized at various distances from the neural axis. The problem becomes compounded further when significant portions away from the neutral axis are stressed into plastic range. A theoretical analysis of the closed hat-section subjected to flexural cyclic loading is first conducted. The axial fatigue characteristics together with the related axial fatigue life formula and its inverted form given by Manson and Muralidharan are adopted for an aluminum alloy used in aircraft construction. A closed-form expression for predicting the flexural fatigue life is then derived for the closed hat-section including materially nonlinear action. A computer program is written to conduct a study of the variables such as the thicknesses of the hat-section and the skin, and the type of alloy used. The study has provided a fundamental understanding of the flexural fatigue life characteristics of a practical structural component used in aircraft when materially nonlinear action is present.

  10. VizieR Online Data Catalog: Spectroscopy and photometry for HAT-P-50--HAT-P-53 (Hartman+, 2015)

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bhatti, W.; Bakos, G. A.; Bieryla, A.; Kovacs, G.; Latham, D. W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Buchhave, L. A.; Torres, G.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Sato, B.; Boisse, I.; Falco, E.; Everett, M. E.; Szklenar, T.; Fulton, B. J.; Shporer, A.; Kovacs, T.; Hansen, T.; Beky, B.; Noyes, R. W.; Lazar, J.; Papp, I.; Sari, P.

    2016-04-01

    The HATNet network consists of six identical fully automated instruments, with four at Fred Lawrence Whipple Observatory (FLWO) in AZ, and two on the roof of the Submillimeter Array Hangar Building at Mauna Kea Observatory (MKO) in HI. The light-gathering elements of each instrument include an 11cm diameter telephoto lens, a Sloan r filter, and a 4K*4K front-side-illuminated CCD camera. Observations made in 2007 and early 2008 were carried out using a Cousins R filter. The instruments have a field of view of 10.6°*10.6° and a pixel scale of 9"/pixel at the center of an image. Additional time-series photometric measurements were obtained for all four of the systems using Keplercam on the FLWO 1.2m telescope. For HAT-P-50 we also obtained follow-up photometry with the CCD imager on the Byrne Observatory at Sedgwick (BOS) 0.8m telescope, located at Sedgwick Reserve in Santa Ynez Valley, CA, and operated by the Las Cumbres Observatory Global Telescope institute (LCOGT). HAT-P-50 was observed with HAT-10/G316 on 2008 Nov-2009 May, with HAT-5/G364 on 2009 May, with HAT-9/G364 on 2008 Dec-2009 May, with BOS on 2012 Feb 15, on 2012 Feb 21 and on 2012 Apr 08, and with Keplercam on 2012 Feb 18, on 2012 Nov 28, on 2012 Dec 23, on 2013 Jan 14, and on 2013 Jan 17. HAT-P-51 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with HAT-10/G165 on 2010 Sep-2011 Jan, with HAT-5/G165 on 2010 Nov-2011 Feb, with HAT-8/G165 on 2010 Nov-2011 Feb, with HAT-6/G209 on 2010 Nov-2011 Feb, with HAT-9/G209 on 2010 Nov-2011 Feb, with HAT-7/G210 on 2010 Nov-2011 Jan, and with Keplercam on 2011 Oct 21, on 2012 Jan 05, on 2012 Oct 05, on 2012 Oct 26, and on 2012 Nov 12. HAT-P-52 was observed with HAT-5/G212 on 2010 Sep-Nov, with HAT-8/G212 on 2010 Aug-Nov, and with Keplercam on 2010 Dec 23, on 2011 Sep 05, on 2011 Sep 27, on 2011 Nov 21, and on 2012 Jan 07. HAT-P-53 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with

  11. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    SciTech Connect

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U/sub 3/O/sub 8/ whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions.

  12. Virtual Screening of Phytochemicals to Novel Target (HAT) Rtt109 in Pneumocystis Jirovecii using Bioinformatics Tools

    PubMed Central

    Adithavarman, Abhinand Ponneri; Dakshinamoorthi, Anusha; David, Darling Chellathai; Ragunath, Padmavathi Kannan

    2016-01-01

    Introduction Pneumocystis jirovecii is a fungus that causes Pneumocystis pneumonia in HIV and other immunosuppressed patients. Treatment of Pneumocystis pneumonia with the currently available antifungals is challenging and associated with considerable adverse effects. There is a need to develop drugs against novel targets with minimal human toxicities. Histone Acetyl Transferase (HAT) Rtt109 is a potential therapeutic target in Pneumocystis jirovecii species. HAT is linked to transcription and is required to acetylate conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form e-N-acetyl lysine. Therefore, inhibitors of HAT can be useful therapeutic options in Pneumocystis pneumonia. Aim To screen phytochemicals against (HAT) Rtt109 using bioinformatics tool. Materials and Methods The tertiary structure of Pneumocystis jirovecii (HAT) Rtt109 was modeled by Homology Modeling. The ideal template for modeling was obtained by performing Psi BLAST of the protein sequence. Rtt109-AcCoA/Vps75 protein from Saccharomyces cerevisiae (PDB structure 3Q35) was chosen as the template. The target protein was modeled using Swiss Modeler and validated using Ramachandran plot and Errat 2. Comprehensive text mining was performed to identify phytochemical compounds with antipneumonia and fungicidal properties and these compounds were filtered based on Lipinski’s Rule of 5. The chosen compounds were subjected to virtual screening against the target protein (HAT) Rtt109 using Molegro Virtual Docker 4.5. Osiris Property Explorer and Open Tox Server were used to predict ADME-T properties of the chosen phytochemicals. Results Tertiary structure model of HAT Rtt 109 had a ProSA score of -6.57 and Errat 2 score of 87.34. Structure validation analysis by Ramachandran plot for the model revealed 97% of amino acids were in the favoured region. Of all the phytochemicals subjected to virtual screening against the target protein (HAT) Rtt109, baicalin

  13. WARM SPITZER PHOTOMETRY OF THREE HOT JUPITERS: HAT-P-3b, HAT-P-4b AND HAT-P-12b

    SciTech Connect

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Fortney, Jonathan J.; Laughlin, Gregory; Lewis, Nikole K.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Sada, Pedro V.; Charbonneau, David; Langton, Jonathan; Showman, Adam P.

    2013-06-20

    We present Warm Spitzer/IRAC secondary eclipse time series photometry of three short-period transiting exoplanets, HAT-P-3b, HAT-P-4b and HAT-P-12b, in both the available 3.6 and 4.5 {mu}m bands. HAT-P-3b and HAT-P-4b are Jupiter-mass objects orbiting an early K and an early G dwarf star, respectively. For HAT-P-3b we find eclipse depths of 0.112%+0.015%-0.030% (3.6 micron) and 0.094%+0.016%-0.009% (4.5 {mu}m). The HAT-P-4b values are 0.142%+0.014%-0.016% (3.6 micron) and 0.122%+0.012%-0.014% 4.5 {mu}m). The two planets' photometry is consistent with inefficient heat redistribution from their day to night sides (and low albedos), but it is inconclusive about possible temperature inversions in their atmospheres. HAT-P-12b is a Saturn-mass planet and is one of the coolest planets ever observed during secondary eclipse, along with the hot Neptune GJ 436b and the hot Saturn WASP-29b. We are able to place 3{sigma} upper limits on the secondary eclipse depth of HAT-P-12b in both wavelengths: <0.042% (3.6 {mu}m) and <0.085% (4.5 {mu}m). We discuss these results in the context of the Spitzer secondary eclipse measurements of GJ 436b and WASP-29b. It is possible that we do not detect the eclipses of HAT-P-12b due to high eccentricity, but find that weak planetary emission in these wavelengths is a more likely explanation. We place 3{sigma} upper limits on the |e cos {omega}| quantity (where e is eccentricity and {omega} is the argument of periapsis) for HAT-P-3b (<0.0081) and HAT-P-4b (<0.0042), based on the secondary eclipse timings.

  14. Warm Spitzer Photometry of Three Hot Jupiters: HAT-P-3b, HAT-P-4b and HAT-P-12b

    NASA Astrophysics Data System (ADS)

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Fortney, Jonathan J.; Lewis, Nikole K.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Sada, Pedro V.; Charbonneau, David; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.

    2013-06-01

    We present Warm Spitzer/IRAC secondary eclipse time series photometry of three short-period transiting exoplanets, HAT-P-3b, HAT-P-4b and HAT-P-12b, in both the available 3.6 and 4.5 μm bands. HAT-P-3b and HAT-P-4b are Jupiter-mass objects orbiting an early K and an early G dwarf star, respectively. For HAT-P-3b we find eclipse depths of 0.112%^{+0.015%}_{-0.030%} (3.6 μm) and 0.094%^{+0.016%}_{-0.009%} (4.5 μm). The HAT-P-4b values are 0.142%^{+0.014%}_{-0.016%} (3.6 μm) and 0.122%^{+0.012%}_{-0.014%}(4.5 μm). The two planets' photometry is consistent with inefficient heat redistribution from their day to night sides (and low albedos), but it is inconclusive about possible temperature inversions in their atmospheres. HAT-P-12b is a Saturn-mass planet and is one of the coolest planets ever observed during secondary eclipse, along with the hot Neptune GJ 436b and the hot Saturn WASP-29b. We are able to place 3σ upper limits on the secondary eclipse depth of HAT-P-12b in both wavelengths: <0.042% (3.6 μm) and <0.085% (4.5 μm). We discuss these results in the context of the Spitzer secondary eclipse measurements of GJ 436b and WASP-29b. It is possible that we do not detect the eclipses of HAT-P-12b due to high eccentricity, but find that weak planetary emission in these wavelengths is a more likely explanation. We place 3σ upper limits on the |e cos ω| quantity (where e is eccentricity and ω is the argument of periapsis) for HAT-P-3b (<0.0081) and HAT-P-4b (<0.0042), based on the secondary eclipse timings.

  15. Effects of non-Kolmogorov turbulence on the spiral spectrum of Hypergeometric-Gaussian laser beams.

    PubMed

    Zhu, Yun; Zhang, Licheng; Hu, Zhengda; Zhang, Yixin

    2015-04-01

    We study the effects of non-Kolmogorov turbulence on the orbital angular momentum (OAM) of Hypergeometric-Gaussian (HyGG) beams in a paraxial atmospheric link. The received power and crosstalk power of OAM states of the HyGG beams are established. It is found that the hollowness parameter of the HyGG beams plays an important role in the received power and crosstalk power. The larger values of hollowness parameter give rise to the higher received power and lower crosstalk power. The results also show that the smaller OAM quantum number and longer wavelength of the launch beam may lead to the higher received power and lower crosstalk power.

  16. Generalization of a Result Involving Product of Generalized Hypergeometric Series due to Ramanujan

    NASA Astrophysics Data System (ADS)

    Shekhawat, Nidhi; Prakash, Om

    The aim of this research paper is to obtain a generalization of the following result involving product of generalized hypergeometric series due to Ramanujan. \\[ {_0F_1}\\left[ {^{-}_{\\rho} ; x} \\right] \\times {_0F_1}\\left[{^{-}_{\\rho} ; - x} \\right] = {_0F_3}\\left[{{_\\rho} , {_{1 \\over 2}}{_\\rho},{^{-}} {_{1 \\over 2}}{_{\\rho + {1 \\over 2}} ; - {{x^2 } \\over 4}} \\right] \\] The results are derived with the help of generalized Kummer’s summation theorem, which recently added in the literature. A few very interesting contiguous results obtained earlier by Kim & Rathie follow special cases of our main findings. The results derived in this paper are simple, interesting, easily established and useful from application point of view.

  17. HATS-15b and HATS-16b: Two Massive Planets Transiting Old G Dwarf Stars

    NASA Astrophysics Data System (ADS)

    Ciceri, S.; Mancini, L.; Henning, T.; Bakos, G.; Penev, K.; Brahm, R.; Zhou, G.; Hartman, J. D.; Bayliss, D.; Jordán, A.; Csubry, Z.; de Val-Borro, M.; Bhatti, W.; Rabus, M.; Espinoza, N.; Suc, V.; Schmidt, B.; Noyes, R.; Howard, A. W.; Fulton, B. J.; Isaacson, H.; Marcy, G. W.; Butler, R. P.; Arriagada, P.; Crane, J. D.; Shectman, S.; Thompson, I.; Tan, T. G.; Lázár, J.; Papp, I.; Sari, P.

    2016-07-01

    We report the discovery of HATS-15 b and HATS-16 b, two massive transiting extrasolar planets orbiting evolved (∼10 Gyr) main-sequence stars. The planet HATS-15 b, which is hosted by a G9 V star (V=14.8 mag), is a hot Jupiter with mass of 2.17\\quad +/- \\quad 0.15 {M}{{J}} and radius of 1.105\\quad +/- \\quad 0.040 {R}{{J}}, and it completes its orbit in about 1.7 days. HATS-16 b is a very massive hot Jupiter with mass of 3.27\\quad +/- \\quad 0.19 {M}{{J}} and radius of 1.30\\quad +/- \\quad 0.15 {R}{{J}}; it orbits around its G3 V parent star (V=13.8 mag) in ∼2.7 days. HATS-16 is slightly active and shows a periodic photometric modulation, implying a rotational period of 12 days, which is unexpectedly short given its isochronal age. This fast rotation might be the result of the tidal interaction between the star and its planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations performed at the ESO La Silla Observatory in Chile, with the Coralie and FEROS spectrographs mounted on the Euler-Swiss and MPG 2.2 m telescopes, respectively. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile. Based in part on data collected at Keck Telescope. Observations obtained with facilities of the Las Cumbres Observatory Global Telescope are used in this paper.

  18. Top-Hat Representation of Turbulence Statistics in Cloud-Topped Boundary Layers: A Large Eddy Simulation Study.

    NASA Astrophysics Data System (ADS)

    Wang, Shouping; Stevens, Bjorn

    2000-02-01

    Large eddy simulation is used to study top-hat parameterizations of second- and third-order scalar statistics in cumulus and stratocumulus cloud-topped boundary layers (CTBLs). Although the top-hat parameterizations based on commonly used conditional sampling methods are a useful approach to modeling the vertical fluxes in the simulated CTBLs, they fail to realistically represent the scalar variances. The reason is that the common sampling methods are based at least in part on the sign of vertical velocity, but not on the sign of the scalars whose variances are represented and that scalars and velocity are not perfectly correlated. Furthermore, the self-correlation nature for a variance means that all the fluctuations contribute to its value, while the top-hat models completely ignore the deviations from the top-hat means and thus considerably degrade the representation of the variance. For the fluxes, however, only the coherent convective elements make the most contribution. Analysis of analytic models and `toy' time series indicates in a more generic setting that the effect of poor correlations between the signal upon which the sampling is based and the signal whose variance is to be represented tends to degrade the ability of top-hat parameterizations to capture the variance. The analysis of toy time series also indicates that variability among individual events within a composite degrades the top-hat representation of the variance more than variability within events. For the vertical velocity-scalar-related third-order moments, the top-hat model gives reasonable estimates for the cumulus CTBL but not for the stratocumulus CTBL. These differences are explained by structural differences (tied to circulation differences in the two CTBLs) in their respective joint probability density functions of vertical velocity and various scalars.

  19. Spitzer Secondary Eclipses of HAT-P-13b

    NASA Astrophysics Data System (ADS)

    Hardy, Ryan A.; Harrington, J.; Hardin, M. R.; Madhusudhan, N.; Cubillos, P.; Blecic, J.; Bakos, G.; Hartman, J. D.

    2013-10-01

    HAT-P-13 b is a transiting hot Jupiter with a slightly eccentric orbit (e = 0.010) inhabiting a two-planet system. The two-planet arrangement provides an opportunity to probe the interior structure of HAT-P-13b. Under equilibrium-tide theory and confirmation that the apsides of planets b and c are in alignment, a measurement of the planet's eccentricity can be related to the planet's tidal Love number k2, which describes the central condensation of the planet's mass and its deformation under tidal effects. A measurement of k2 could constrain interior models of HAT-P-13b. HAT-P-13b's orbit is configured favorably for refinement of the eccentricity by secondary eclipse timing observations, which provide direct measurements of ecosω. In 2010, Spitzer observed two secondary eclipses of HAT-P-13b in the 3.6- and 4.5-μm IRAC bandpasses. We present secondary eclipse times and depths; joint models of the HAT-P-13 system that incorporate transit photometry and radial velocity data; and constraints on the atmospheric chemistry of HAT-P-13b that suggest solar-abundance composition without a thermal inversion. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA, which provided support for this work. This work was supported in part by NASA Planetary Atmospheres Grant NNX13AF38G.

  20. Electronic and thermoelectric properties of Mexican hat bands in van-der-Waals materials

    NASA Astrophysics Data System (ADS)

    Wickramaratne, Darshana; Zahid, Ferdows; Lake, Roger

    2015-03-01

    Mexican hat dispersions are relatively common in few-layer two-dimensional materials. In one to four monolayers of the group-III chalcogenides (GaS, GaSe, InS, InSe) and Bi2Se3 the valence band undergoes a band inversion from a parabolic to an inverted Mexican hat dispersion as the film thickness is reduced from bulk to a single monolayer. The band inversion is robust against changes in stacking order, omission or inclusion of spin-orbit coupling and the choice of functional. The Mexican hat dispersion results in a 1/√{ E} singularity in the two-dimensional density of states and a step-function turn on in the density of modes. The largest radius of the ring of states occurs for a single monolayer of each material. The dispersion with the largest radius coincides with the maximum power factor and ZT for a material at room temperature. Ab-initio electronic structure calculations are used with a Landauer approach to calculate the thermoelectric transport coefficients. Analytical models of the Mexican hat and the parabolic dispersions are used for comparison and analysis. Vertically biased bilayer graphene could serve as an experimental test-bed for measuring this effect since the radius of the Mexican hat band edge increases linearly with vertical electric field. Support by the NSF and SRC-NRI Project 2204.001 (NSF-ECCS-1124733), FAME, one of six centers of STARnet, a SRC program sponsored by MARCO and DARPA and the use of XSEDE NSF Grant # OCI-1053575.

  1. VizieR Online Data Catalog: Photometry and spectroscopy of HAT-P-57 (Hartman+, 2015)

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bakos, G. A.; Buchhave, L. A.; Torres, G.; Latham, D. W.; Kovacs, G.; Bhatti, W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Huang, C. X.; Beky, B.; Bieryla, A.; Quinn, S. N.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Fischer, D. A.; Noyes, R. W.; Falco, E.; Esquerdo, G. A.; Knox, R. P.; Hinz, P.; Lazar, J.; Papp, I.; Sari, P.

    2016-05-01

    The star HAT-P-57 was observed by the HATNet wide-field photometric instruments between the nights of UT 2009 May 12 and UT 2009 September 14. A total of 622 observations of a 10.6°*10.6° field centered at RA=06h24m, decl.=+30° were made with the HAT-5 telescope in Arizona, and 3202 observations of this same field were made with the HAT-9 telescope in Hawaii. We used a Sloan r filter. Photometric follow-up observations of HAT-P-57 were carried out with KeplerCam on the Fred Lawrence Whipple Observatory (FLWO) 1.2m telescope. We observed ingress events on the nights of 2010 April 3 and 2012 April 24, in i and g-bands respectively, and a full transit on the night of 2010 June 26 in z-band. Additional photometric follow-up observations were carried out with the FLWO 1.2m on the night of 2015 May 12. All time-series photometric data that we collected for HAT-P-57 are provided in Table1. Spectroscopic observations were obtained using the HIgh-Resolution Echelle Spectrometer (HIRES) on the Keck-I 10m telescope between UT 2010 June 27 and UT 2012 March 10. A total of 24 HIRES observations were collected during this time period, including 14 observations made through the I2 cell (e.g., Marcy & Butler, 1992PASP..104..270M), and 10 observations without the I2 cell. These latter observations were obtained on the night of UT 2010 June 27, primarily during a planetary transit (Section 3.3 discusses the analysis of these observations in more detail). Table2 gives the relative radial velocity measurements obtained with the I2 Doppler pipeline, the radial velocity measurements obtained from the CCFs, and the Bisector Spans for the HIRES observations. (2 data files).

  2. Expansions of the solutions to the confluent Heun equation in terms of the Kummer confluent hypergeometric functions

    NASA Astrophysics Data System (ADS)

    Ishkhanyan, T. A.; Ishkhanyan, A. M.

    2014-08-01

    We examine the series expansions of the solutions of the confluent Heun equation in terms of three different sets of the Kummer confluent hypergeometric functions. The coefficients of the expansions in general obey three-term recurrence relations defining double-sided infinite series; however, four-term and two-term relations are also possible in particular cases. The conditions for left- and/or right-side termination of the derived series are discussed.

  3. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    SciTech Connect

    1997-05-01

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy`s (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. The U.S. Nuclear Regulatory Commission (NRC) has developed regulations for the issuance of a general license for the custody and long-term care of UMTRA Project disposal sites in 10 CFR Part 40. The purpose of this general license is to ensure that the UMTRA Project disposal sites will be cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed, the NRC requires the DOE to submit a site-specific LTSP. The DOE prepared this LTSP to meet this requirement for the Mexican Hat disposal site. The general license becomes effective when the NRC concurs with the DOE`s determination of completion of remedial action for the disposal site and the NRC formally accepts this LTSP. This LTSP describes the long-term surveillance program the DOE will implement to ensure that the Mexican Hat disposal site performs as designed. The program is based on two distinct types of activities: (1) site inspections to identify potential threats to disposal cell integrity, and (2) monitoring of selected seeps to observe changes in flow rates and water quality. The LTSP is based on the UMTRA Project long-term surveillance program guidance and meets the requirements of 10 CFR {section}40.27(b) and 40 CFR {section}192.03. 18 refs., 6 figs., 1 tab.

  4. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    SciTech Connect

    1996-01-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  5. Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation.

    PubMed

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-02-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied garcinol, an inhibitor of the HATs of the p300 (EP300 binding protein)/CBP (CREB-binding protein) family, and the HATs of the PCAF (p300/CBP-associated factor) family. As comparative agent we applied C646, a specific inhibitor that selectively blocks HATS of the p300/CBP family. Immunochemical analysis reveals differences in histone H3 acetylation in the honeybee brain, in response to the injection of either C646 or garcinol. Behavioral assessment reveals that the two drugs cause memory impairment of different nature when injected after associative conditioning: processes disturbed by garcinol are annihilated by the established transcription blocker actinomycin D and thus seem to require transcription processes. Actions of C646 are unaltered by actinomycin D, and thus seem to be independent of transcription. The outcome of our different approaches as summarized suggests that distinct HATs contribute to different acetylation-mediated processes in memory formation. We further deduce that the acetylation-mediated processes in memory formation comprise transcription-dependent and transcription-independent mechanisms.

  6. Propagation of hypergeometric laser beams in a medium with a parabolic refractive index

    NASA Astrophysics Data System (ADS)

    Kotlyar, V. V.; Kovalev, A. A.; Nalimov, A. G.

    2013-12-01

    An expression to describe the complex amplitude of a family of paraxial hypergeometric laser beams propagating in a parabolic-index fiber is proposed. A particular case of a Gaussian optical vortex propagating in a parabolic-index fiber is studied. Under definite parameters, the Gaussian optical vortices become the modes of the medium. This is a new family of paraxial modes derived for the parabolic-index medium. A wide class of solutions of nonparaxial Helmholtz equations that describe modes in a parabolic refractive index medium is derived in the cylindrical coordinate system. As the solutions derived are proportional to Kummer’s functions, only those of them which are coincident with the nonparaxial Laguerre-Gaussian modes possess a finite energy, meaning that they are physically implementable. A definite length of the graded-index fiber is treated as a parabolic lens, and expressions for the numerical aperture and the focal spot size are deduced. An explicit expression for the radii of the rings of a binary lens approximating a parabolic-index lens is derived. Finite-difference time-domain simulation has shown that using a binary parabolic-index microlens with a refractive index of 1.5, a linearly polarized Gaussian beam can be focused into an elliptic focal spot which is almost devoid of side-lobes and has a smaller full width at half maximum diameter of 0.45 of the incident wavelength.

  7. High Hats, Swiss Cheese, and Fluorescent Lighting?

    SciTech Connect

    McCullough, Jeffrey J.; Gordon, Kelly L.

    2002-08-30

    For DOE, PNNL is conducting a competitive procurement to promote market introduction of new residential recessed downlights (also known as ''recessed cans'' or ''high hats'') that are airtight, rated for insulated ceilings, and hard-wired for CFLs. This paper discusses the potential energy savings of new high-efficiency downlights, and the results of product testing to date. Recessed downlights are the most popular residential lighting fixtures in the United States, with 21.7 million fixtures sold in 2000. An estimated 350 million are currently installed in American homes. Recessed cans are relatively inexpensive, and provide an unobtrusive, directed source of light for kitchens, hallways, and living rooms. Recessed cans are energy-intensive in three ways. First, virtually all recessed cans currently installed in the residential sector use incandescent light sources, typically reflector-type lamps drawing 65-150 watts. Second, heat from incandescent lamps adds to air-conditioning loads. Third, most installed recessed cans are not airtight, so they allow conditioned air to escape from the living area into unconditioned spaces such as attics. Addressing both lighting energy use and air leakage in recessed cans has proven challenging. Lighting energy efficiency is greatly improved by using CFLs. Air leakage can be addressed by making fixtures airtight. But when CFLs are used in an airtight recessed can, heat generated by the lamp and ballast is trapped within the fixture. Excessive heat causes reduced light output and shorter lifespan of the CFL. The procurement was designed to overcome these technical challenges and make new products available in the marketplace.

  8. Design and fabrication of hat-shaped stiffened panel by resin transfer molding method

    SciTech Connect

    Bell, R.; Ibekwe, S.I.; Mensah, P.F.; Chehl, S.S.

    1998-12-31

    Hat-shaped stiffened composite panels were fabricated by resin transfer molding (RTM) process. As application of these compression load bearing panels in aircraft wings and fuselage increases, this promising manufacturing technique would contribute towards the goal of attaining reduced part counts and cheaper manufacturing costs. Rigid foam which increases the structural efficiency of panels was utilized in this process. Also Balsa wood was considered as an alternative to the rigid foam and employed as a permanent mandrel in fabricating one of the panels. Buckling analysis result by finite element method and modified closed form solution suggested by Agarwal et al. (1974) agree. Once this process is fine-tuned, it would provide a cheaper method of fabricating composite hat-stiffened panels.

  9. HATS-25b through HATS-30b: A Half–dozen New Inflated Transiting Hot Jupiters from the HATSouth Survey

    NASA Astrophysics Data System (ADS)

    Espinoza, N.; Bayliss, D.; Hartman, J. D.; Bakos, G. Á.; Jordán, A.; Zhou, G.; Mancini, L.; Brahm, R.; Ciceri, S.; Bhatti, W.; Csubry, Z.; Rabus, M.; Penev, K.; Bento, J.; de Val-Borro, M.; Henning, T.; Schmidt, B.; Suc, V.; Wright, D. J.; Tinney, C. G.; Tan, T. G.; Noyes, R.

    2016-10-01

    We report six new inflated hot Jupiters (HATS-25b through HATS-30b) discovered using the HATSouth global network of automated telescopes. The planets orbit stars with V magnitudes in the range of ∼12–14 and have masses in the largely populated 0.5{M}J{--}0.7{M}J region of parameter space but span a wide variety of radii, from 1.17{R}J to 1.75{R}J. HATS-25b, HATS-28b, HATS-29b, and HATS-30b are typical inflated hot Jupiters ({R}p=1.17{--}1.26{R}J) orbiting G–type stars in short period (P = 3.2-4.6 days) orbits. However, HATS-26b ({R}p=1.75{R}J, P=3.3024 days) and HATS-27b ({R}p=1.50{R}J, P=4.6370 days) stand out as highly inflated planets orbiting slightly evolved F stars just after and in the turn–off points, respectively, which are among the least dense hot Jupiters, with densities of 0.153 {{g}} {{cm}}-3 and 0.180 {{g}} {{cm}}-3, respectively. All the presented exoplanets but HATS-27b are good targets for future atmospheric characterization studies, while HATS-27b is a prime target for Rossiter—McLaughlin monitoring in order to determine its spin–orbit alignment given the brightness (V = 12.8) and stellar rotational velocity (v\\sin i≈ 9.3 km s‑1) of the host star. These discoveries significantly increase the number of inflated hot Jupiters known, contributing to our understanding of the mechanism(s) responsible for hot Jupiter inflation. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations made with the MPG 2.2 m Telescope at the ESO

  10. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    SciTech Connect

    1996-02-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE`s Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  11. HAT-P-20b-HAT-P-23b: FOUR MASSIVE TRANSITING EXTRASOLAR PLANETS

    SciTech Connect

    Bakos, G. A.; Hartman, J.; Torres, G.; Latham, D. W.; Noyes, R. W.; Kipping, D.; Esquerdo, G. A.; Beky, B.; Perumpilly, G.; Everett, M.; Sasselov, D. D.; Stefanik, R. P.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Marcy, G. W.; Howard, A. W.; Shporer, A.; Buchhave, L. A.; Lazar, J.; and others

    2011-12-01

    We report the discovery of four relatively massive (2-7 M{sub J}) transiting extrasolar planets. HAT-P-20b orbits the moderately bright V = 11.339 K3 dwarf star GSC 1910-00239 on a circular orbit, with a period P = 2.875317 {+-} 0.000004 days, transit epoch T{sub c} = 2455080.92661 {+-} 0.00021 (BJD{sub UTC}), and transit duration 0.0770 {+-} 0.0008 days. The host star has a mass of 0.76 {+-} 0.03 M{sub Sun }, radius of 0.69 {+-} 0.02 R{sub Sun }, effective temperature 4595 {+-} 80 K, and metallicity [Fe/H] = +0.35 {+-} 0.08. The planetary companion has a mass of 7.246 {+-} 0.187 M{sub J} and a radius of 0.867 {+-} 0.033 R{sub J} yielding a mean density of 13.78 {+-} 1.50 g cm{sup -3}. HAT-P-21b orbits the V = 11.685 G3 dwarf star GSC 3013-01229 on an eccentric (e = 0.228 {+-} 0.016) orbit, with a period P = 4.124481 {+-} 0.000007 days, transit epoch T{sub c} = 2454996.41312 {+-} 0.00069, and transit duration 0.1530 {+-} 0.0027 days. The host star has a mass of 0.95 {+-} 0.04 M{sub Sun }, radius of 1.10 {+-} 0.08 R{sub Sun }, effective temperature 5588 {+-} 80 K, and metallicity [Fe/H] = +0.01 {+-} 0.08. The planetary companion has a mass of 4.063 {+-} 0.161 M{sub J} and a radius of 1.024 {+-} 0.092 R{sub J} yielding a mean density of 4.68{sup +1.59}{sub -0.99} g cm{sup -3}. HAT-P-21b is a borderline object between the pM and pL class planets, and the transits occur near apastron. HAT-P-22b orbits the bright V = 9.732 G5 dwarf star HD 233731 on a circular orbit, with a period P = 3.212220 {+-} 0.000009 days, transit epoch T{sub c} = 2454930.22001 {+-} 0.00025, and transit duration 0.1196 {+-} 0.0014 days. The host star has a mass of 0.92 {+-} 0.03 M{sub Sun }, radius of 1.04 {+-} 0.04 R{sub Sun }, effective temperature 5302 {+-} 80 K, and metallicity [Fe/H] = +0.24 {+-} 0.08. The planet has a mass of 2.147 {+-} 0.061 M{sub J} and a compact radius of 1.080 {+-} 0.058 R{sub J} yielding a mean density of 2.11{sup +0.40}{sub -0.29} g cm{sup -3}. The host star also

  12. INDEPENDENT DISCOVERY OF THE TRANSITING EXOPLANET HAT-P-14b

    SciTech Connect

    Simpson, E. K.; Barros, S. C. C.; Pollacco, D.; Faedi, F.; McCormac, J.; Brown, D. J. A.; Collier Cameron, A.; Enoch, B.; Skillen, I.; Stempels, H. C.; Boisse, I.; Hebrard, G.; Bouchy, F.; Sorensen, P.; Street, R. A.; Anderson, D.; Bento, J.; Butters, O. W.; Haswell, C. A.; Hebb, L.

    2011-05-15

    We present SuperWASP observations of HAT-P-14b, a hot Jupiter discovered by Torres et al. The planet was found independently by the SuperWASP team and named WASP-27b after follow-up observations had secured the discovery, but prior to the publication by Torres et al. Our analysis of HAT-P-14/WASP-27 is in good agreement with the values found by Torres et al. and we provide additional evidence against astronomical false positives. Due to the brightness of the host star, V{sub mag} = 10, HAT-P-14b is an attractive candidate for further characterization observations. The planet has a high impact parameter and the primary transit is close to grazing. This could readily reveal small deviations in the orbital parameters indicating the presence of a third body in the system, which may be causing the small but significant orbital eccentricity. Our results suggest that the planet may undergo a grazing secondary eclipse. However, even a non-detection would tightly constrain the system parameters.

  13. Formulating robust linear regression estimation as a one-class LDA criterion: discriminative hat matrix.

    PubMed

    Dufrenois, F; Noyer, J C

    2013-02-01

    Linear discriminant analysis, such as Fisher's criterion, is a statistical learning tool traditionally devoted to separating a training dataset into two or even several classes by the way of linear decision boundaries. In this paper, we show that this tool can formalize the robust linear regression problem as a robust estimator will do. More precisely, we develop a one-class Fischer's criterion in which the maximization provides both the regression parameters and the separation of the data in two classes: typical data and atypical data or outliers. This new criterion is built on the statistical properties of the subspace decomposition of the hat matrix. From this angle, we improve the discriminative properties of the hat matrix which is traditionally used as outlier diagnostic measure in linear regression. Naturally, we call this new approach discriminative hat matrix. The proposed algorithm is fully nonsupervised and needs only the initialization of one parameter. Synthetic and real datasets are used to study the performance both in terms of regression and classification of the proposed approach. We also illustrate its potential application to image recognition and fundamental matrix estimation in computer vision.

  14. Vector Boson Jets with BlackHat and Sherpa

    SciTech Connect

    Berger, C.F.; Bern, Z.; Dixon, Lance J.; Cordero, F.Febres; Forde, D.; Gleisberg, T.; Ita, H.; Kosower, D.A.; Maitre, D.; /Durham U.

    2010-08-25

    We review recent NLO QCD results for W, Z + 3-jet production at hadron colliders, computing using BlackHat and SHERPA, and including also some new results for Z + 3-jet production for the LHC at 7 TeV. We report new progress towards the NLO cross section for W + 4-jet production. In particular, we show that the virtual matrix elements produced by BlackHat are numerically stable. We also show that with an improved integrator and tree-level matrix elements from BlackHat, SHERPA produces well-behaved real-emission contributions. As an illustration, we present the real-emission contributions - including dipole-subtraction terms - to the p{sub T} distribution of the fourth jet, for a single subprocess with the maximum number of gluons.

  15. The quantum harmonic oscillator on the sphere and the hyperbolic plane: {kappa}-dependent formalism, polar coordinates, and hypergeometric functions

    SciTech Connect

    Carinena, Jose F.; Ranada, Manuel F.; Santander, Mariano

    2007-10-15

    A nonlinear model representing the quantum harmonic oscillator on the sphere and the hyperbolic plane is solved in polar coordinates (r,{phi}) by making use of a curvature-dependent formalism. The curvature {kappa} is considered as a parameter and then the radial Schroedinger equation becomes a {kappa}-dependent Gauss hypergeometric equation. The energy spectrum and the wave functions are exactly obtained in both the sphere S{sup 2} ({kappa}>0) and the hyperbolic plane H{sup 2} ({kappa}<0). A comparative study between the spherical and the hyperbolic quantum results is presented.

  16. Social factors in occupational health: a history of hard hats.

    PubMed

    Rosenberg, Beth; Levenstein, Charles

    2010-01-01

    Personal protective equipment (PPE) is the least desirable way to ensure workplace safety, and it is difficult to use consistently. Hard hats are different; they have cachet and are often worn even when they are not required. We investigated the history of this personal protective equipment to see if there were any lessons that could be applied to other forms of PPE. We learned that what makes hard hats special are social factors that are specific to a certain time and place. The importance of social factors illuminates the requirement that cultural and social norms of workers be included in any kind of worker safety and health training.

  17. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    ERIC Educational Resources Information Center

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  18. Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration

    PubMed Central

    Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

    2016-01-01

    Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer’s disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID:27454757

  19. Hats off to Problem-Solving with Couples

    ERIC Educational Resources Information Center

    Li, Chi-Sing; Lin, Yu-Fen; Nelson, Judy; Eckstein, Daniel

    2008-01-01

    The purpose of this article is to demonstrate how counselors can use de Bono's Six Thinking Hats problem-solving technique in their work with couples. Part 1 of the article focuses on an introduction to the technique, including a theoretical rationale and supporting research. Following a detailed description of the process of using the model as a…

  20. "The Cat in the Hat." A Literature Unit.

    ERIC Educational Resources Information Center

    Williams, Susan

    Intended as an aid to primary school teachers, this handbook presents a literature unit based on the children's book, "The Cat in the Hat" (Dr. Seuss). It begins with sample lesson plans, a unit planner, getting to know the book and author, and suggestions for using the unit activities. Next, a section offers unit activities focusing on unit…

  1. Design and evaluation of a bolted joint for a discrete carbon-epoxy rod-reinforced hat section

    NASA Technical Reports Server (NTRS)

    Rousseau, Carl Q.; Baker, Donald J.

    1996-01-01

    The use of prefabricated pultruded carbon-epoxy rods has reduced the manufacturing complexity and costs of stiffened composite panels while increasing the damage tolerance of the panels. However, repairability of these highly efficient discrete stiffeners has been a concern. Design, analysis, and test results are presented in this paper for a bolted-joint repair for the pultruded rod concept that is capable of efficiently transferring axial loads in a hat-section stiffener on the upper skin segment of a heavily loaded aircraft wing component. A tension and a compression joint design were evaluated. The tension joint design achieved approximately 1.0% strain in the carbon-epoxy rod-reinforced hat-section and failed in a metal fitting at 166% of the design ultimate load. The compression joint design failed in the carbon-epoxy rod-reinforced hat-section test specimen area at approximately 0.7% strain and at 110% of the design ultimate load. This strain level of 0.7% in compression is similar to the failure strain observed in previously reported carbon-epoxy rod-reinforced hat-section column tests.

  2. Design and Evaluation of a Bolted Joint for a Discrete Carbon-Epoxy Rod-Reinforced Hat Section

    NASA Technical Reports Server (NTRS)

    Baker, Donald J.; Rousseau, Carl Q.

    1996-01-01

    The use of pre-fabricated pultruded carbon-epoxy rods has reduced the manufacturing complexity and costs of stiffened composite panels while increasing the damage tolerance of the panels. However, repairability of these highly efficient discrete stiffeners has been a concern. Design, analysis, and test results are presented in this paper for a bolted-joint repair for the pultruded rod concept that is capable of efficiently transferring axial loads in a hat-section stiffener on the upper skin segment of a heavily loaded aircraft wing component. A tension and a compression joint design were evaluated. The tension joint design achieved approximately 1.0 percent strain in the carbon-epoxy rod-reinforced hat-section and failed in a metal fitting at 166 percent of the design ultimate load. The compression joint design failed in the carbon-epoxy rod-reinforced hat-section test specimen area at approximately 0.7 percent strain and at 110 percent of the design ultimate load. This strain level of 0.7 percent in compression is similar to the failure strain observed in previously reported carbon-epoxy rod-reinforced hat-section column tests.

  3. Exoplanet Transits Registered at the Universidad de Monterrey Observatory. I. HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b, and WASP-10b

    NASA Astrophysics Data System (ADS)

    Sada, Pedro V.; Ramón-Fox, Felipe G.

    2016-02-01

    Forty transits of the exoplanets HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b, and WASP-10b were recorded with the 0.36 m telescope at the Universidad de Monterrey Observatory. The images were captured with a standard Johnson-Cousins Rc and Ic and Sloan z’ filters and processed to obtain individual light curves of the events. These light curves were successfully combined for each system to obtain a resulting one of higher quality, but with a slightly larger time sampling rate. A reduction by a factor of about four in per-point scatter was typically achieved, resulting in combined light curves with a scatter of ∼1 mmag. The noise characteristics of the combined light curves were verified by comparing Allan variance plots of the residuals. The combined light curves for each system, along with radial velocity measurements from the literature when available, were modeled using a Monte Carlo method to obtain the essential parameters that characterize the systems. Our results for all these systems confirm the derived transit parameters (the planet-to-star radius ratio, {R}{{p}}/{R}*; the scaled semimajor axis, a/{R}*; the orbital inclination, i; in some cases the eccentricity, e; and argument of periastron of the orbit, ω), validating the methodology. This technique can be used by small college observatories equipped with modest-sized telescopes to help characterize known extrasolar planet systems. In some instances, the uncertainties of the essential transit parameters are also reduced. For HAT-P-23b, in particular, we derive a planet size 4.5 ± 1.0% smaller. We also derive improved linear periods for each system, useful for scheduling observations.

  4. 49. Taken from highline; "McKinley hat" remains on "B" furnace; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. Taken from high-line; "McKinley hat" remains on "B" furnace; no longer used, "McKinley hat was open receptacle with bell below. Hat carried charge to furnace top, dumping it to bell; bell locked onto furnace top, dropping charge into furnace. Looking east - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  5. Measurements of the UVR protection provided by hats used at school.

    PubMed

    Gies, Peter; Javorniczky, John; Roy, Colin; Henderson, Stuart

    2006-01-01

    The importance of protection against solar ultraviolet radiation (UVR) in childhood has lead to SunSmart policies at Australian schools, in particular primary schools, where children are encouraged and in many cases required to wear hats at school. Hat styles change regularly and the UVR protection provided by some of the hat types currently used and recommended for sun protection by the various Australian state cancer councils had not been previously evaluated. The UVR protection of the hats was measured using UVR sensitive polysulphone film badges attached to different facial sites on rotating headforms. The sun protection type hats included in this study were broad-brimmed hats, "bucket hats" and legionnaires hats. Baseball caps, which are very popular, were also included. The broad-brimmed hats and bucket hats provided the most UVR protection for the six different sites about the face and head. Legionnaires hats also provided satisfactory UVR protection, but the caps did not provide UVR protection to many of the facial sites. The highest measured UVR protection factors for facial sites other than the forehead were 8 to 10, indicating that, while some hats can be effective, they need to be used in combination with other forms of UVR protection.

  6. White Hats Chasing Black Hats: Careers in IT and the Skills Required to Get There. Advisory from Professionals

    ERIC Educational Resources Information Center

    Fulton, Eric; Lawrence, Cameron; Clouse, Shawn

    2013-01-01

    The aim of this paper is to illuminate the exciting world in which "white hat crackers" operate and to suggest topics that can help prepare students to enter this high-demand field. While currently there is extraordinary demand for graduates to fill these positions that have relatively high starting salaries, employers find it difficult…

  7. RELATIVE PHOTOMETRY OF HAT-P-1b OCCULTATIONS

    SciTech Connect

    Beky, Bence; Holman, Matthew J.; Noyes, Robert W.; Sasselov, Dimitar D.; Gilliland, Ronald L.; Bakos, Gaspar A.; Winn, Joshua N.

    2013-06-01

    We present Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph observations of two occultations of the transiting exoplanet HAT-P-1b. By measuring the planet to star flux ratio near opposition, we constrain the geometric albedo of the planet, which is strongly linked to its atmospheric temperature gradient. An advantage of HAT-P-1 as a target is its binary companion ADS 16402 A, which provides an excellent photometric reference, simplifying the usual steps in removing instrumental artifacts from HST time-series photometry. We find that without this reference star, we would need to detrend the lightcurve with the time of the exposures as well as the first three powers of HST orbital phase, and this would introduce a strong bias in the results for the albedo. However, with this reference star, we only need to detrend the data with the time of the exposures to achieve the same per-point scatter, therefore we can avoid most of the bias associated with detrending. Our final result is a 2{sigma} upper limit of 0.64 for the geometric albedo of HAT-P-1b between 577 and 947 nm.

  8. HAT-P-44b, HAT-P-45b, AND HAT-P-46b: Three transiting hot Jupiters in possible multi-planet systems

    SciTech Connect

    Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Csubry, Z.; Penev, K.; De Val-Borro, M.; Torres, G.; Latham, D. W.; Bieryla, A.; Béky, B.; Noyes, R. W.; Esquerdo, G. A.; Kovács, G.; Johnson, J. A.; Howard, A. W.; Marcy, G. W.; Buchhave, L. A.; Fischer, D. A.; Everett, M.; Szklenár, T.; and others

    2014-06-01

    We report the discovery by the HATNet survey of three new transiting extrasolar planets orbiting moderately bright (V = 13.2, 12.8, and 11.9) stars. The planets have orbital periods of 4.3012, 3.1290, and 4.4631 days, masses of 0.35, 0.89, and 0.49 M {sub J}, and radii of 1.24, 1.43, and 1.28 R {sub J}. The stellar hosts have masses of 0.94, 1.26, and 1.28 M {sub ☉}. Each system shows significant systematic variations in its residual radial velocities, indicating the possible presence of additional components. Based on its Bayesian evidence, the preferred model for HAT-P-44 consists of two planets, including the transiting component, with the outer planet having a period of 872 days, eccentricity of 0.494 ± 0.081, and a minimum mass of 4.0 M {sub J}. Due to aliasing we cannot rule out alternative solutions for the outer planet having a period of 220 days or 438 days. For HAT-P-45, at present there is not enough data to justify the additional free parameters included in a multi-planet model; in this case a single-planet solution is preferred, but the required jitter of 22.5 ± 6.3 m s{sup –1} is relatively high for a star of this type. For HAT-P-46 the preferred solution includes a second planet having a period of 78 days and a minimum mass of 2.0 M {sub J}, however the preference for this model over a single-planet model is not very strong. While substantial uncertainties remain as to the presence and/or properties of the outer planetary companions in these systems, the inner transiting planets are well characterized with measured properties that are fairly robust against changes in the assumed models for the outer planets. Continued radial velocity monitoring is necessary to fully characterize these three planetary systems, the properties of which may have important implications for understanding the formation of hot Jupiters.

  9. Broad-band spectrophotometry of HAT-P-32 b: search for a scattering signature in the planetary spectrum

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; Bernt, I.; Herrero, E.; Hoyer, S.; Kirk, J.; Wheatley, P. J.; Seeliger, M.; Mackebrandt, F.; von Essen, C.; Strassmeier, K. G.; Granzer, T.; Künstler, A.; Dhillon, V. S.; Marsh, T. R.; Gaitan, J.

    2016-11-01

    Multicolour broad-band transit observations offer the opportunity to characterize the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previously published light curves for a homogeneous analysis of the broad-band transmission spectrum from the Sloan u' band to the Sloan z' band. Our results rule out cloud-free planetary atmosphere models of solar metallicity. Furthermore, a discrepancy at reddest wavelengths to previously published results makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes.

  10. Broad-band spectrophotometry of HAT-P-32 b: Search for a scattering signature in the planetary spectrum

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; Bernt, I.; Herrero, E.; Hoyer, S.; Kirk, J.; Wheatley, P. J.; Seeliger, M.; Mackebrandt, F.; von Essen, C.; Strassmeier, K. G.; Granzer, T.; Künstler, A.; Dhillon, V. S.; Marsh, T. R.; Gaitan, J.

    2016-08-01

    Multi-colour broad-band transit observations offer the opportunity to characterise the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previously published light curves for a homogeneous analysis of the broad-band transmission spectrum from the Sloan u' band to the Sloan z' band. Our results rule out cloud-free planetary atmosphere models of solar metallicity. Furthermore, a discrepancy at reddest wavelengths to previously published results makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes.

  11. An investigation of higher-order effects in modeling exoplanet HAT-P-7b

    NASA Astrophysics Data System (ADS)

    Kurth, Susan Anne

    In its search for Earth-like planets, NASA's Kepler mission observed over 200,000 stars. Among these systems were the class of planets known as the "hot Jupiters." These are giant gaseous planets with periods less than 10 days. Here I present an analysis of the Kepler observations of the exoplanet HAT-P-7b, a hot Jupiter with an orbital period of 2.2 days, a mass of 1.8 MJ, and a radius of 1.5 RJ. Due to its very close proximity to its host star, the planet has a day-side temperature of 2800 K and a night-side temperature of 1950 K. The tight orbit also causes planetary reflection, as well as higher-order effects in the system such as ellipsoidal variations, Doppler beaming, and gravity darkening. My thesis explores these effects on the Kepler HAT-P-7 light curve using the state of the art Eclipsing Light Curve (ELC) code. The "short cadence" data from Kepler contain 2 million measurements, which I phase folded and binned to get robust uncertainties, resulting in a final data set with 2,704 points. Because of the exquisitely high precision of the data (few ppm level), the physical effects mentioned above need to be accounted for. Including these effects enables me to accurately solve for the system parameters.

  12. Top hat electrostatic analyzer for far-field electric propulsion plume diagnostics

    SciTech Connect

    Victor, Allen L.; Zurbuchen, Thomas H.; Gallimore, Alec D.

    2006-01-15

    The design, development, and testing of the top hat electric propulsion plume analyzer (TOPAZ) are presented for far-field electric propulsion plume diagnostics. The trend towards high-power thruster development will require plume diagnostic techniques capable of measuring high-energy particles as well as low-energy ions produced from charge-exchange collisions due to elevated facility background pressures. TOPAZ incorporates a 'top hat' design with a geometrical analyzer constant of 100 resulting in a wide energy range and a high-energy resolution. SIMION, an ion trajectory analysis program, was used to predict characteristics of the analyzer. An ion beam accelerator system confirms the computational results. TOPAZ provides an energy resolution of 2.7%, field of view of 112 deg. x 26 deg. (azimuthal by elevation) with an angular resolution in each direction of 2 deg., and a demonstrated energy-per-charge acceptance range of 5-15 keV. An energy profile measurement of the NASA-173Mv1 Hall thruster demonstrates instrument operation in a Hall thruster plume.

  13. The refined physical properties of transiting exoplanetary system WASP-11/HAT-P-10

    SciTech Connect

    Wang, Xiao-bin; Gu, Sheng-hong; Wang, Yi-bo; Cameron, Andrew Collier; Hui, Ho-Keung; Kwok, Chi-Tai; Yeung, Bill; Leung, Kam-Cheung

    2014-04-01

    The transiting exoplanetary system WASP-11/HAT-P-10 was observed using the CCD camera at Yunnan Observatories, China from 2008 to 2011, and four new transit light curves were obtained. Combined with published radial velocity measurements, the new transit light curves are analyzed along with available photometric data from the literature using the Markov Chain Monte Carlo technique, and the refined physical parameters of the system are derived, which are compatible with the results of two discovery groups, respectively. The planet mass is M{sub p} = 0.526 ± 0.019 M{sub J} , which is the same as West et al.'s value, and more accurately, the planet radius R{sub p} = 0.999{sub −0.018}{sup +0.029} R{sub J} is identical to the value of Bakos et al. The new result confirms that the planet orbit is circular. By collecting 19 available mid-transit epochs with higher precision, we make an orbital period analysis for WASP-11b/HAT-P-10b, and derive a new value for its orbital period, P = 3.72247669 days. Through an (O – C) study based on these mid-transit epochs, no obvious transit timing variation signal can be found for this system during 2008-2012.

  14. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    PubMed

    Räsänen, Esa; Pulkkinen, Otto; Virtanen, Tuomas; Zollner, Manfred; Hennig, Holger

    2015-01-01

    Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits) have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy. PMID:26039256

  15. Fluctuations of Hi-Hat Timing and Dynamics in a Virtuoso Drum Track of a Popular Music Recording

    PubMed Central

    Räsänen, Esa; Pulkkinen, Otto; Virtanen, Tuomas; Zollner, Manfred; Hennig, Holger

    2015-01-01

    Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro’s one-handed hi-hat pattern in “I Keep Forgettin’”—one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits) have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro’s drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy. PMID:26039256

  16. Preparation of Size-Controlled Hat-Stacked Carbon Nanofibers

    NASA Astrophysics Data System (ADS)

    Sato, Y.; Yokoyama, A.; Motomiya, K.; Jeyadevan, B.; Tohji, K.

    2007-03-01

    Hat-stacked carbon nanofibers (H-CNFs) were size-separated using a multi-step microfiltration process employing polycarbonate membrane filters with respective cylindrical pore diameters of 2.0, 1.2 and 0.4 μm after being cut and dispersed in distilled water using sonication in a mixture of concentrated H2SO4 and HNO3. The average length of separated H-CNFs was 2.4 μm, 1.2 μm and 0.6 μm, respectively.

  17. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    NASA Technical Reports Server (NTRS)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2011-01-01

    Unmanned aerial systems, advanced cockpits, and air traffic management are all seeing dramatic increases in automation. However, while automation may take on some tasks previously performed by humans, humans will still be required to remain in the system for the foreseeable future. The collaboration between humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  18. General survey of hAT transposon superfamily with highlight on hobo element in Drosophila.

    PubMed

    Ladevèze, Véronique; Chaminade, Nicole; Lemeunier, Françoise; Periquet, Georges; Aulard, Sylvie

    2012-09-01

    The hAT transposons, very abundant in all kingdoms, have a common evolutionary origin probably predating the plant-fungi-animal divergence. In this paper we present their general characteristics. Members of this superfamily belong to Class II transposable elements. hAT elements share transposase, short terminal inverted repeats and eight base-pairs duplication of genomic target. We focus on hAT elements in Drosophila, especially hobo. Its distribution, dynamics and impact on genome restructuring in laboratory strains as well as in natural populations are reported. Finally, the evolutionary history of hAT elements, their domestication and use as transgenic tools are discussed.

  19. Tectonic Geomorphology and Volcano-Tectonic Interaction in the Eastern Boundary of the Southern Cascades (Hat Creek Graben), California, USA

    NASA Astrophysics Data System (ADS)

    Paguican, E. M. R.; Bursik, M. I.

    2015-12-01

    The eastern boundary of the Southern Cascades (Hat Creek Graben), California, USA is an extensively faulted volcanic corridor with spectacular, high, steep scarps in a bedrock of late Tertiary and Quaternary volcanic and sedimentary deposits. The morphology of the graben is a result of the plate motions associated with multiple tectonic provinces, faulting, and recurring volcanic activity from more than 500 vents, over the past 7 my. The graben is at the boundary between two distinct geologic and geomorphic areas -- the Cascade Range on the west and the Modoc Plateau on the east -- between Mt. Shasta and Medicine Lake Highlands volcano, and Lassen Volcanic Center on the north and south, respectively. This study describes the geomorphological and tectonic features, their alignment and distribution, to understand the volcano-tectonic and geomorphology relationships in the Hat Creek Graben. We interpret topographic models generated from satellite images to create a database of volcanic centers and structures, and analyze the spatial distribution of the volcanic centers in the Hat Creek Graben. Poisson Nearest Neighbor analysis reveals a clustered distribution of volcanic centers, implying continuous or recurrent activity of magma sources as it propagates to the surface. Volcanic centers in the Hat Creek Graben have multiple preferred alignments, typical for extensional tectonic environments because of competing regional and local stress field influences and the presence of pre-existing, near-surface fractures. Most small stratovolcanoes ("lava cones") on the west are influenced by normal regional stress, and have crater amphitheater openings perpendicular to the maximum horizontal stress (σHmax), while those on the east, in a transcurrent regional stress regime, are at an acute angle. These results can be used as an indicator of the degree of impingement of the Walker Lane shear zone on the Cascades region.

  20. Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B).

    PubMed

    Haigney, Allison; Ricketts, M Daniel; Marmorstein, Ronen

    2015-12-18

    The HAT-B enzyme complex is responsible for acetylating newly synthesized histone H4 on lysines K5 and K12. HAT-B is a multisubunit complex composed of the histone acetyltransferase 1 (Hat1) catalytic subunit and the Hat2 (rbap46) histone chaperone. Hat1 is predominantly localized in the nucleus as a member of a trimeric NuB4 complex containing Hat1, Hat2, and a histone H3-H4 specific histone chaperone called Hif1 (NASP). In addition to Hif1 and Hat2, Hat1 interacts with Asf1 (anti-silencing function 1), a histone chaperone that has been reported to be involved in both replication-dependent and -independent chromatin assembly. To elucidate the molecular roles of the Hif1 and Asf1 histone chaperones in HAT-B histone binding and acetyltransferase activity, we have characterized the stoichiometry and binding mode of Hif1 and Asf1 to HAT-B and the effect of this binding on the enzymatic activity of HAT-B. We find that Hif1 and Asf1 bind through different modes and independently to HAT-B, whereby Hif1 binds directly to Hat2, and Asf1 is only capable of interactions with HAT-B through contacts with histones H3-H4. We also demonstrate that HAT-B is significantly more active against an intact H3-H4 heterodimer over a histone H4 peptide, independent of either Hif1 or Asf1 binding. Mutational studies further demonstrate that HAT-B binding to the histone tail regions is not sufficient for this enhanced activity. Based on these data, we propose a model for HAT-B/histone chaperone assembly and acetylation of H3-H4 complexes.

  1. S2HAT: Scalable Spherical Harmonic Transform Library

    NASA Astrophysics Data System (ADS)

    Stompor, Radek

    2011-10-01

    Many problems in astronomy and astrophysics require a computation of the spherical harmonic transforms. This is in particular the case whenever data to be analyzed are distributed over the sphere or a set of corresponding mock data sets has to be generated. In many of those contexts, rapidly improving resolutions of both the data and simulations puts increasingly bigger emphasis on our ability to calculate the transforms quickly and reliably. The scalable spherical harmonic transform library S2HAT consists of a set of flexible, massively parallel, and scalable routines for calculating diverse (scalar, spin-weighted, etc) spherical harmonic transforms for a class of isolatitude sky grids or pixelizations. The library routines implement the standard algorithm with the complexity of O(n^3/2), where n is a number of pixels/grid points on the sphere, however, owing to their efficient parallelization and advanced numerical implementation, they achieve very competitive performance and near perfect scalability. S2HAT is written in Fortran 90 with a C interface. This software is a derivative of the spherical harmonic transforms included in the HEALPix package and is based on both serial and MPI routines of its version 2.01, however, since version 2.5 this software is fully autonomous of HEALPix and can be compiled and run without the HEALPix library.

  2. HAT-P-18b AND HAT-P-19b: TWO LOW-DENSITY SATURN-MASS PLANETS TRANSITING METAL-RICH K STARS

    SciTech Connect

    Hartman, J. D.; Bakos, G. A.; Torres, G.; Noyes, R. W.; Latham, D. W.; Buchhave, L. A.; Fueresz, G.; Perumpilly, G.; Beky, B.; Stefanik, R. P.; Sasselov, D. D.; Esquerdo, G. A.; Everett, M.; Csubry, Z.; Sato, B.; Kovacs, G.; Fischer, D. A.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.

    2011-01-01

    We report the discovery of two new transiting extrasolar planets. HAT-P-18b orbits the V = 12.759 K2 dwarf star GSC 2594-00646, with a period P = 5.508023 {+-} 0.000006 days, transit epoch T{sub c} = 2454715.02174 {+-} 0.00020 (BJD), and transit duration 0.1131 {+-} 0.0009 days. The host star has a mass of 0.77 {+-} 0.03 M{sub sun}, radius of 0.75 {+-} 0.04 R{sub sun}, effective temperature 4803 {+-} 80 K, and metallicity [Fe/H] = +0.10 {+-} 0.08. The planetary companion has a mass of 0.197 {+-} 0.013 M{sub J} and radius of 0.995 {+-} 0.052 R{sub J}, yielding a mean density of 0.25 {+-} 0.04 g cm{sup -3}. HAT-P-19b orbits the V = 12.901 K1 dwarf star GSC 2283-00589, with a period P = 4.008778 {+-} 0.000006 days, transit epoch T{sub c} = 2455091.53417 {+-} 0.00034 (BJD), and transit duration 0.1182 {+-} 0.0014 days. The host star has a mass of 0.84 {+-} 0.04 M{sub sun}, radius of 0.82 {+-} 0.05 R{sub sun}, effective temperature 4990 {+-} 130 K, and metallicity [Fe/H] = +0.23 {+-} 0.08. The planetary companion has a mass of 0.292 {+-} 0.018 M{sub J} and radius of 1.132 {+-} 0.072 R{sub J}, yielding a mean density of 0.25 {+-} 0.04 g cm{sup -3}. The radial velocity residuals for HAT-P-19 exhibit a linear trend in time, which indicates the presence of a third body in the system. Comparing these observations with theoretical models, we find that HAT-P-18b and HAT-P-19b are each consistent with a hydrogen-helium-dominated gas giant planet with negligible core mass. HAT-P-18b and HAT-P-19b join HAT-P-12b and WASP-21b in an emerging group of low-density Saturn-mass planets, with negligible inferred core masses. However, unlike HAT-P-12b and WASP-21b, both HAT-P-18b and HAT-P-19b orbit stars with super-solar metallicity. This calls into question the heretofore suggestive correlation between the inferred core mass and host star metallicity for Saturn-mass planets.

  3. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    ERIC Educational Resources Information Center

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  4. Single-strain-gage force/stiffness buckling prediction techniques on a hat-stiffened panel

    NASA Technical Reports Server (NTRS)

    Hudson, Larry D.; Thompson, Randolph C.

    1991-01-01

    Predicting the buckling characteristics of a test panel is necessary to ensure panel integrity during a test program. A single-strain-gage buckling prediction method was developed on a hat-stiffened, monolithic titanium buckling panel. The method is an adaptation of the original force/stiffness method which requires back-to-back gages. The single-gage method was developed because the test panel did not have back-to-back gages. The method was used to predict buckling loads and temperatures under various heating and loading conditions. The results correlated well with a finite element buckling analysis. The single-gage force/stiffness method was a valid real-time and post-test buckling prediction technique.

  5. THE DISCOVERY OF ELLIPSOIDAL VARIATIONS IN THE KEPLER LIGHT CURVE OF HAT-P-7

    SciTech Connect

    Welsh, William F.; Orosz, Jerome A.; Seager, Sara; Fortney, Jonathan J.; Jenkins, Jon; Rowe, Jason F.; Koch, David; Borucki, William J.

    2010-04-20

    We present an analysis of the early Kepler observations of the previously discovered transiting planet HAT-P-7b. The light curve shows the transit of the star, the occultation of the planet, and the orbit phase-dependent light from the planet. In addition, phase-dependent light from the star is present, known as 'ellipsoidal variations'. The very nearby planet (only four stellar radii away) gravitationally distorts the star and results in a flux modulation twice per orbit. The ellipsoidal variations can confuse interpretation of the planetary phase curve if not self-consistently included in the modeling. We fit the light curve using the Roche potential approximation and derive improved planet and orbit parameters.

  6. All or nothing... or just a hat? Farmers' sun protection behaviors.

    PubMed

    Silk, Kami J; Parrott, Roxanne L

    2006-04-01

    Farmers have an increased risk for developing skin cancers and thus comprise an important audience for messages that address sun protection practices. This project examines sun protection behaviors of farmers from southeastern Georgia and uses those measured behaviors to conduct a cluster analysis. Farmers (N = 480) were clustered into three groups using six variables that measured their frequency of sun protective and purchasing behaviors. The three groups were characterized as either engaging heavily in sun protective behaviors, engaging in none of the recommended sun protective behaviors, or only wearing hats as a sun protective behavior. Practitioners seeking to develop health message interventions that target farming populations should consider the current behaviors of subgroups of farmers when developing audience segments to tailor messages aimed at increasing sun protective behaviors. Practical recommendations for message content targeted toward the subgroups of farmers are provided.

  7. Warm Spitzer Observations of Three Hot Exoplanets: XO-4b, HAT-P-6b, and HAT-P-8b

    NASA Astrophysics Data System (ADS)

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Sada, Pedro V.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Fortney, Jonathan J.; Charbonneau, David; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2012-02-01

    We analyze Warm Spitzer/Infrared Array Camera observations of the secondary eclipses of three planets, XO-4b, HAT-P-6b, and HAT-P-8b. We measure secondary eclipse amplitudes at 3.6 μm and 4.5 μm for each target. XO-4b exhibits a stronger eclipse depth at 4.5 μm than at 3.6 μm, which is consistent with the presence of a temperature inversion. HAT-P-8b shows a stronger eclipse amplitude at 3.6 μm and is best described by models without a temperature inversion. The eclipse depths of HAT-P-6b can be fitted with models with a small or no temperature inversion. We consider our results in the context of a postulated relationship between stellar activity and temperature inversion and a relationship between irradiation level and planet dayside temperature, as discussed by Knutson et al. and Cowan & Agol, respectively. Our results are consistent with these hypotheses, but do not significantly strengthen them. To measure accurate secondary eclipse central phases, we require accurate ephemerides. We obtain primary transit observations and supplement them with publicly available observations to update the orbital ephemerides of the three planets. Based on the secondary eclipse timing, we set upper boundaries for ecos (ω) for HAT-P-6b, HAT-P-8b, and XO-4b and find that the values are consistent with circular orbits.

  8. WARM SPITZER OBSERVATIONS OF THREE HOT EXOPLANETS: XO-4b, HAT-P-6b, AND HAT-P-8b

    SciTech Connect

    Todorov, Kamen O.; Deming, Drake; Knutson, Heather A.; Burrows, Adam; Sada, Pedro V.; Cowan, Nicolas B.; Agol, Eric; Desert, Jean-Michel; Charbonneau, David; Fortney, Jonathan J.; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2012-02-10

    We analyze Warm Spitzer/Infrared Array Camera observations of the secondary eclipses of three planets, XO-4b, HAT-P-6b, and HAT-P-8b. We measure secondary eclipse amplitudes at 3.6 {mu}m and 4.5 {mu}m for each target. XO-4b exhibits a stronger eclipse depth at 4.5 {mu}m than at 3.6 {mu}m, which is consistent with the presence of a temperature inversion. HAT-P-8b shows a stronger eclipse amplitude at 3.6 {mu}m and is best described by models without a temperature inversion. The eclipse depths of HAT-P-6b can be fitted with models with a small or no temperature inversion. We consider our results in the context of a postulated relationship between stellar activity and temperature inversion and a relationship between irradiation level and planet dayside temperature, as discussed by Knutson et al. and Cowan and Agol, respectively. Our results are consistent with these hypotheses, but do not significantly strengthen them. To measure accurate secondary eclipse central phases, we require accurate ephemerides. We obtain primary transit observations and supplement them with publicly available observations to update the orbital ephemerides of the three planets. Based on the secondary eclipse timing, we set upper boundaries for ecos ({omega}) for HAT-P-6b, HAT-P-8b, and XO-4b and find that the values are consistent with circular orbits.

  9. One-Loop Calculations with BlackHat

    SciTech Connect

    Berger, C.F.; Bern, Z.; Dixon, L.J.; Cordero, F.Febres; Forde, D.; Ita, H.; Kosower, D.A.; Maitre, D.

    2008-08-01

    We describe BlackHat, an automated C++ program for calculating one-loop amplitudes, and the techniques used in its construction. These include the unitarity method and on-shell recursion. The other ingredients are compact analytic formulae for tree amplitudes for four-dimensional helicity states. The program computes amplitudes numerically, using analytic formula only for the tree amplitudes, the starting point for the recursion, and the loop integrals. We make use of recently developed on-shell methods for evaluating coefficients of loop integrals, in particular a discrete Fourier projection as a means of improving numerical stability. We illustrate the good numerical stability of this approach by computing six-, seven- and eight-gluon amplitudes in QCD and comparing against known analytic results.

  10. Friction pull plug welding: top hat plug design

    NASA Technical Reports Server (NTRS)

    Coletta, Edmond R. (Inventor); Cantrell, Mark A. (Inventor)

    2002-01-01

    Friction Pull Plug Welding is a solid state repair process for defects up to one inch in length, only requiring single sided tooling, or outside skin line (OSL), for preferred usage on flight hardware. The most prevalent defect associated with Friction Pull Plug Welding (FPPW) was a top side or inside skin line (ISL) lack of bonding. Bonding was not achieved at this location due to the reduction in both frictional heat and welding pressure between the plug and plate at the end of the weld. Thus, in order to eliminate the weld defects and increase the plug strength at the plug `top` a small `hat` section is added to the pull plug for added frictional heating and pressure.

  11. Friction pull plug welding: top hat plug design

    NASA Technical Reports Server (NTRS)

    Coletta, Edmond R. (Inventor); Cantrell, Mark A. (Inventor)

    2001-01-01

    Friction Pull Plug Welding is a solid state repair process for defects up to one inch in length, only requiring single sided tooling, or outside skin line (OSL), for preferred usage on flight hardware. The most prevalent defect associated with Friction Pull Plug Welding (FPPW) was a top side or inside skin line (ISL) lack of bonding. Bonding was not achieved at this location due to the reduction in both frictional heat and welding pressure between the plug and plate at the end of the weld. Thus, in order to eliminate the weld defects and increase the plug strength at the plug `top` a small `hat` section is added to the pull plug for added frictional heating and pressure.

  12. Supernova 1987 A - The nebular loops and 'Napoleon's Hat'

    NASA Astrophysics Data System (ADS)

    Wang, L.; Wampler, E. J.

    1992-08-01

    We discuss observations of the circumstellar environment of SN 1987A that were obtained between August 1989 and January 1992 at ESO's New Technology Telescope. We find that the angular dimensions of the two nebular loops (Wampler et al., 1990) have not changed during this period. Therefore these loops are confined to a small region. The expansion velocity of the loops is less than about 40 km/s if the loops expanded with a uniform velocity from a common origin. This structure and velocity is hard to reproduce with existing wind interaction models. Our observations further suggest that the Napoleon's Hat nebula does not originate from the general background LMC dust, but from a bow shock dust whose origins are closely related to the stellar winds from the progenitor star of SN 1987A.

  13. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    SciTech Connect

    Not Available

    1994-09-01

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone.

  14. 30 CFR 75.1720-1 - Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats, or hard caps... STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1720-1 Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in...

  15. 30 CFR 77.1710-1 - Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats or hard caps... Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in color from those worn by experienced miners shall be worn...

  16. Kepler and Ground-Based Transits of the exo-Neptune HAT-P-11b

    NASA Technical Reports Server (NTRS)

    Deming, Drake; Sada, Pedro V.; Jackson, Brian; Peterson, Steven W.; Agol, Eric; Knutson, Heather A.; Jennings, Donald E.; Haase, Plynn; Bays, Kevin

    2011-01-01

    We analyze 26 archival Kepler transits of the exo-Neptune HAT-P-11b, supplemented by ground-based transits observed in the blue (B band) and near-IR (J band). Both the planet and host star are smaller than previously believed; our analysis yields Rp = 4.31 R xor 0.06 R xor and Rs = 0.683 R solar mass 0.009 R solar mass, both about 3 sigma smaller than the discovery values. Our ground-based transit data at wavelengths bracketing the Kepler bandpass serve to check the wavelength dependence of stellar limb darkening, and the J-band transit provides a precise and independent constraint on the transit duration. Both the limb darkening and transit duration from our ground-based data are consistent with the new Kepler values for the system parameters. Our smaller radius for the planet implies that its gaseous envelope can be less extensive than previously believed, being very similar to the H-He envelope of GJ 436b and Kepler-4b. HAT-P-11 is an active star, and signatures of star spot crossings are ubiquitous in the Kepler transit data. We develop and apply a methodology to correct the planetary radius for the presence of both crossed and uncrossed star spots. Star spot crossings are concentrated at phases 0.002 and +0.006. This is consistent with inferences from Rossiter-McLaughlin measurements that the planet transits nearly perpendicular to the stellar equator. We identify the dominant phases of star spot crossings with active latitudes on the star, and infer that the stellar rotational pole is inclined at about 12 deg 5 deg to the plane of the sky. We point out that precise transit measurements over long durations could in principle allow us to construct a stellar Butterfly diagram to probe the cyclic evolution of magnetic activity on this active K-dwarf star.

  17. Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah. [Contains glossary

    SciTech Connect

    Not Available

    1987-10-01

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs.

  18. Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltranferase HAT1

    SciTech Connect

    Lebel, E.A.; Tafrov, S.; Boukamp, P.

    2010-06-01

    Hat1 was the first histone acetyltransferase identified, however its biological function is still unclear. In this report, we show that the human Hat1 has two isoforms. Isoform a has 418 amino acids (aa) and is localized exclusively in the nuclear matrix of normal human keratinocytes (NHKs). Isoform b has 334 aa and is located in thecytoplasm, the nucleoplasm, attached to the chromatin and to the nuclear matrix. Immunohistochemical analyses revealed that the bulk of Hat1 is confined to the nucleus, with much lesser amounts in the cytoplasm. Cells undergoing mitotic division have an elevated amount of Hat1 compared to non-mitotic ones. NHKs exposed to hydrogen peroxide (H2O2) or to a beam of high mass and energy (HZE) ion particles expressed bright nuclear staining for Hat1, a phenotype that was not observed in NHKs exposed to &947;-rays. We established that the enhanced nuclear staining for Hat1 in response to these treatments is regulated by the PI3K and the MAPK signaling pathways. Our observations clearly implicate Hat1 in the cellular response assuring the survival of the treated cells.

  19. HATS-11b AND HATS-12b: Two Transiting Hot Jupiters Orbiting Subsolar Metallicity Stars Selected for the K2 Campaign 7

    NASA Astrophysics Data System (ADS)

    Rabus, M.; Jordán, A.; Hartman, J. D.; Bakos, G. Á.; Espinoza, N.; Brahm, R.; Penev, K.; Ciceri, S.; Zhou, G.; Bayliss, D.; Mancini, L.; Bhatti, W.; de Val-Borro, M.; Csbury, Z.; Sato, B.; Tan, T.-G.; Henning, T.; Schmidt, B.; Bento, J.; Suc, V.; Noyes, R.; Lázár, J.; Papp, I.; Sári, P.

    2016-10-01

    We report the discovery of two transiting extrasolar planets from the HATSouth survey. HATS-11, a V = 14.1 G0-star shows a periodic 12.9 mmag dip in its light curve every 3.6192 days and a radial velocity variation consistent with a Keplerian orbit. HATS-11 has a mass of 1.000+/- 0.060 {M}⊙ , a radius of 1.444+/- 0.057 {R}⊙ and an effective temperature of 6060+/- 150 K, while its companion is a 0.85+/- 0.12 {M}{{J}}, 1.510+/- 0.078 {R}{{J}} planet in a circular orbit. HATS-12 shows a periodic 5.1 mmag flux decrease every 3.1428 days and Keplerian RV variations around a V = 12.8 F-star. HATS-12 has a mass of 1.489+/- 0.071 {M}⊙ , a radius of 2.21+/- 0.21 {R}⊙ , and an effective temperature of 6408+/- 75 K. For HATS-12b, our measurements indicate that this is a 2.38+/- 0.11 {M}{{J}}, 1.35+/- 0.17 {R}{{J}} planet in a circular orbit. Both host stars show subsolar metallicities of -0.390+/- 0.060 dex and -0.100+/- 0.040 dex, respectively, and are (slightly) evolved stars. In fact, HATS-11 is among the most metal-poor and, HATS-12, with a {log}{g}\\star of 3.923+/- 0.065, is among the most evolved stars hosting a hot-Jupiter planet. Importantly, HATS-11 and HATS-12 have been observed in long cadence by Kepler as part of K2 campaign 7 (EPIC216414930 and EPIC218131080 respectively). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based in part on

  20. Antioxidant Activity/Capacity Measurement. 2. Hydrogen Atom Transfer (HAT)-Based, Mixed-Mode (Electron Transfer (ET)/HAT), and Lipid Peroxidation Assays.

    PubMed

    Apak, Reşat; Özyürek, Mustafa; Güçlü, Kubilay; Çapanoğlu, Esra

    2016-02-10

    Measuring the antioxidant activity/capacity levels of food extracts and biological fluids is useful for determining the nutritional value of foodstuffs and for the diagnosis, treatment, and follow-up of numerous oxidative stress-related diseases. Biologically, antioxidants play their health-beneficial roles via transferring a hydrogen (H) atom or an electron (e(-)) to reactive species, thereby deactivating them. Antioxidant activity assays imitate this action; that is, antioxidants are measured by their H atom transfer (HAT) or e(-) transfer (ET) to probe molecules. Antioxidant activity/capacity can be monitored by a wide variety of assays with different mechanisms, including HAT, ET, and mixed-mode (ET/HAT) assays, generally without distinct boundaries between them. Understanding the principal mechanisms, advantages, and disadvantages of the measurement assays is important for proper selection of method for valid evaluation of antioxidant properties in desired applications. This work provides a general and up-to-date overview of HAT-based, mixed-mode (ET/HAT), and lipid peroxidation assays available for measuring antioxidant activity/capacity and the chemistry behind them, including a critical evaluation of their advantages and drawbacks.

  1. HAT-P-34b-HAT-P-37b: FOUR TRANSITING PLANETS MORE MASSIVE THAN JUPITER ORBITING MODERATELY BRIGHT STARS

    SciTech Connect

    Bakos, G. A.; Hartman, J. D.; Csubry, Z.; Penev, K.; Torres, G.; Beky, B.; Latham, D. W.; Bieryla, A.; Quinn, S.; Szklenar, T.; Esquerdo, G. A.; Noyes, R. W.; Buchhave, L. A.; Kovacs, G.; Shporer, A.; Fischer, D. A.; Johnson, J. A.; Howard, A. W.; Marcy, G. W.; Sato, B.; and others

    2012-07-15

    We report the discovery of four transiting extrasolar planets (HAT-P-34b-HAT-P-37b) with masses ranging from 1.05 to 3.33 M{sub J} and periods from 1.33 to 5.45 days. These planets orbit relatively bright F and G dwarf stars (from V = 10.16 to V = 13.2). Of particular interest is HAT-P-34b which is moderately massive (3.33 M{sub J}), has a high eccentricity of e = 0.441 {+-} 0.032 at a period of P = 5.452654 {+-} 0.000016 days, and shows hints of an outer component. The other three planets have properties that are typical of hot Jupiters.

  2. Two HAT-P-16b Spitzer Eclipse Observations

    NASA Astrophysics Data System (ADS)

    Hardin, Matthew R.; Harrington, J.; Fortney, J. J.; Foster, A. S.; Cubillos, P. E.; Hardy, R. A.; Bowman, O.; Blecic, J.; Hartman, J. D.; . Bakos, G.

    2013-10-01

    We report two Spitzer secondary eclipses of exoplanet HAT-P-16b. Discovered by Buchhave et al. (2010), this hot Jupiter is four times more massive than Jupiter and has a blackbody equilibrium temperature of 1626 K. We find a 3.6-micron eclipse depth of 0.129% ± 0.013% and a 4.5-micron eclipse depth of 0.210% ± 0.015%. These correspond to brightness temperatures of 1804 ± 71 K and 1946 ± 69 K respectively. We use the eclipse depths to constrain atmospheric models both with and without a thermal inversion, and find that those with a thermal inversion more closely match the data. We also refine the orbit of the planet, and confirm a small yet significant eccentricity of 0.0435 ± 0.0013. These observations are part of the Spitzer Exoplanet Target of Opportunity program. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA, which provided support for this work.

  3. Reserves determination using type-curve matching and EMB methods in the Medicine Hat shallow gas field

    SciTech Connect

    West, S.L.; Cochrane, P.J.R.

    1995-05-01

    Tight, shallow gas reservoirs in the Western Canada basin present a number of unique challenges in determining reserves accurately. Traditional methods such as decline analysis and material balance are inaccurate owing to the formation`s low permeabilities and poor pressure data. The low permeabilities cause long transient periods that are not separated easily from production decline with conventional decline analysis, resulting in lower confidence in selecting the appropriate decline characteristics (exponential or harmonic), which effects recovery factors and remaining reserves significantly. Limited, poor-quality pressure data and commingled production from the three producing zones results in nonrepresentative pressure data and hence inaccurate material-balance analysis. This paper presents two new methods of reserve evaluation that address the problems described above for tight, shallow gas in the Medicine Hat field. The first method applies type-curve matching, which combines the analytical pressure solutions of the diffusivity equation (transient) with the empirical decline equation. The second method is an extended material balance (EMB), which incorporates the gas deliverability theory to allow selection of appropriate p/z derivatives without relying on pressure data. Excellent results were obtained when these two methods were applied to 10 properties that gather gas from 2,300 wells. The two independent techniques resulted in similar production forecasts and reserves, confirming their validity. They proved to be valuable, practical tools in overcoming the various challenges of tight, shallow gas and in improving the accuracy in gas-reserves determination in the Medicine Hat field.

  4. Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT

    PubMed Central

    Ponnan, Prija; Kumar, Ajit; Singh, Prabhjot; Gupta, Prachi; Joshi, Rini; Saso, Luciano; Prasad, Ashok K.; Rastogi, Ramesh C.; Parmar, Virinder S.; Raj, Hanumantharao G.

    2014-01-01

    Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates to receptor proteins (RP). Later, TAase was identified as calreticulin (CR), an endoplasmic reticulum luminal protein. CR was termed calreticulin transacetylase (CRTAase). Our persistent study revealed that CR like other families of histone acetyltransferases (HATs) such as p300, Rtt109, PCAF, and ESA1, undergoes autoacetylation. The autoacetylated CR was characterized as a stable intermediate in CRTAase catalyzed protein acetylation, and similar was the case with ESA1. The autoacetylation of CR like that of HATs was found to enhance protein-protein interaction. CR like HAT-1, CBP, and p300 mediated the acylation of RP utilizing acetyl CoA and propionyl CoA as the substrates. The similarities between CRTAase and HATs in mediating protein acylation are highlighted in this review. PMID:24688408

  5. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    NASA Technical Reports Server (NTRS)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  6. VizieR Online Data Catalog: HAT-P-36 and WASP-11/HAT-P-10 light curves (Mancini+, 2015)

    NASA Astrophysics Data System (ADS)

    Mancini, L.; Esposito, M.; Covino, E.; Raia, G.; Southworth, J.; Tregloan-Reed, J.; Biazzo, K.; Bonomo, A.; Desidera, S.; Lanza, A. F.; Maciejewski, G.; Poretti, E.; Sozzetti, A.; Borsa, F.; Bruni, I.; Ciceri, S.; Claudi, R.; Cosentino, R.; Gratton, R.; Martinez Fiorenzano, A. F.; Lodato, G.; Lorenzi, V.; Marzari, F.; Murabito, S.; Affer, L.; Bignamini, A.; Bedin, L. R.; Boccato, C.; Damasso, M.; Henning, T.; Maggio, A.; Micela, G.; Molinari, E.; Pagano, I.; Piotto, G.; Rainer, M.; Scandariato, G.; Smareglia, R.; Zanmar Sanchez; R.

    2015-06-01

    3 light curves of three transit events of the extrasolar planet HAT-P-36b and 3 light curves of two transit events of the extrasolar planet WASP-11b/HAT-P-10b. Three of the datasets were obtained using the Zeiss 1.23-m telescope (filter: Cousins I) at the Observatory of Calar Alto (Spain), two with the Cassini 1.52-m telescope (filter: Gunn r) at the Astronomical Observatory of Bologna in Loiano (Italy), and one with the IAC 80-cm telescope (filter: Cousins R) at the Teide Observatory on the island of Tenerife (Spain). (6 data files).

  7. Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

    PubMed Central

    Pirooznia, Sheila K.; Elefant, Felice

    2013-01-01

    Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome have traditionally been studied in the context of early developmental and heritable cognitive disorders, recent studies point to aberrant histone acetylation status as a key mechanism underlying acquired inappropriate alterations of genome structure and function in post-mitotic neurons during the aging process. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the lifetime of neurons through mechanisms related to loss of function of histone acetyltransferase (HAT) activity. Several HATs have been shown to participate in vital neuronal functions such as regulation of neuronal plasticity and memory formation. As such, dysregulation of such HATs has been implicated in the pathogenesis associated with age-associated neurodegenerative diseases and cognitive decline. In order to counteract the loss of HAT function in neurodegenerative diseases, the current therapeutic strategies involve the use of small molecules called histone deacetylase (HDAC) inhibitors that antagonize HDAC activity and thus enhance acetylation levels. Although this strategy has displayed promising therapeutic effects, currently used HDAC inhibitors lack target specificity, raising concerns about their applicability. With rapidly evolving literature on HATs and their respective functions in mediating neuronal survival and higher order brain function such as learning and memory, modulating the function of specific HATs holds new promises as a therapeutic tool in neurodegenerative diseases. In this review, we focus on the recent progress in research regarding epigenetic histone acetylation mechanisms underlying neuronal activity and cognitive function. We discuss the current understanding of specific HDACs and HATs in

  8. A scan statistic for binary outcome based on hypergeometric probability model, with an application to detecting spatial clusters of Japanese encephalitis.

    PubMed

    Zhao, Xing; Zhou, Xiao-Hua; Feng, Zijian; Guo, Pengfei; He, Hongyan; Zhang, Tao; Duan, Lei; Li, Xiaosong

    2013-01-01

    As a useful tool for geographical cluster detection of events, the spatial scan statistic is widely applied in many fields and plays an increasingly important role. The classic version of the spatial scan statistic for the binary outcome is developed by Kulldorff, based on the Bernoulli or the Poisson probability model. In this paper, we apply the Hypergeometric probability model to construct the likelihood function under the null hypothesis. Compared with existing methods, the likelihood function under the null hypothesis is an alternative and indirect method to identify the potential cluster, and the test statistic is the extreme value of the likelihood function. Similar with Kulldorff's methods, we adopt Monte Carlo test for the test of significance. Both methods are applied for detecting spatial clusters of Japanese encephalitis in Sichuan province, China, in 2009, and the detected clusters are identical. Through a simulation to independent benchmark data, it is indicated that the test statistic based on the Hypergeometric model outweighs Kulldorff's statistics for clusters of high population density or large size; otherwise Kulldorff's statistics are superior.

  9. Warm Spitzer Secondary Transit Photometry of Hot Jupiters HAT-P-6b, HAT-P-8b and XO-4b

    NASA Astrophysics Data System (ADS)

    Todorov, Kamen 0.; Deming, D.; Knutson, H.; Burrows, A.; Sada, P.; Agol, E.; Desert, J.; Fortney, J. J.; Charbonneau, D.; Cowan, N. B.; Laughlin, G.; Langton, J.; Showman, A. P.; Lewis, N. K.

    2011-05-01

    An increasing number of transiting exoplanets have been observed at secondary eclipse. By measuring the depth of these eclipses at different wavelengths it is possible to distinguish between planets that have a temperature inversion in the upper layers of their atmospheres and ones that do not. We observed XO-4b, HAT-P-6b and HAT-P-8b during secondary eclipse with the IRAC instrument on Warm Spitzer at 3.6 and 4.5 microns. We compare the resulting eclipse depths to atmospheric models with and without temperature inversions, and thereby place constraints on the properties of their day-side atmospheres and heat redistribution efficiencies. The XO-4b and HAT-P-6b eclipse depths agree best with inverted models, while HAT-P-8b exhibits no temperature inversion. Knutson et al. (2010) hypothesized a correlation between lack of a temperature inversion and host star activity. Also, Cowan & Agol (2011), investigated the dependence between planetary effective temperatures, assuming no redistribution, and heat redistribution efficiency, finding that the hottest planets re-distribute heat inefficiently. We compare our planets with the Knutson and Cowan-Agol relations, and we find that they are consistent with the Knutson et al. activity hypothesis, but they are not hot enough to test the Cowan & Agol hypothesis.

  10. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    SciTech Connect

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  11. KEPLER AND GROUND-BASED TRANSITS OF THE EXO-NEPTUNE HAT-P-11b

    SciTech Connect

    Deming, Drake; Jackson, Brian; Jennings, Donald E.; Sada, Pedro V.; Peterson, Steven W.; Haase, Flynn; Bays, Kevin; Agol, Eric; Knutson, Heather A.

    2011-10-10

    We analyze 26 archival Kepler transits of the exo-Neptune HAT-P-11b, supplemented by ground-based transits observed in the blue (B band) and near-IR (J band). Both the planet and host star are smaller than previously believed; our analysis yields R{sub p} = 4.31 R{sub +} {+-} 0.06 R{sub +} and R{sub s} = 0.683 R{sub sun} {+-} 0.009 R{sub sun}, both about 3{sigma} smaller than the discovery values. Our ground-based transit data at wavelengths bracketing the Kepler bandpass serve to check the wavelength dependence of stellar limb darkening, and the J-band transit provides a precise and independent constraint on the transit duration. Both the limb darkening and transit duration from our ground-based data are consistent with the new Kepler values for the system parameters. Our smaller radius for the planet implies that its gaseous envelope can be less extensive than previously believed, being very similar to the H-He envelope of GJ 436b and Kepler-4b. HAT-P-11 is an active star, and signatures of star spot crossings are ubiquitous in the Kepler transit data. We develop and apply a methodology to correct the planetary radius for the presence of both crossed and uncrossed star spots. Star spot crossings are concentrated at phases -0.002 and +0.006. This is consistent with inferences from Rossiter-McLaughlin measurements that the planet transits nearly perpendicular to the stellar equator. We identify the dominant phases of star spot crossings with active latitudes on the star, and infer that the stellar rotational pole is inclined at about 12{sup 0} {+-} 5{sup 0} to the plane of the sky. We point out that precise transit measurements over long durations could in principle allow us to construct a stellar Butterfly diagram to probe the cyclic evolution of magnetic activity on this active K-dwarf star.

  12. Dynamical Constraints on the Core Mass of Hot Jupiter HAT-P-13b

    NASA Astrophysics Data System (ADS)

    Buhler, Peter Benjamin; Knutson, Heather; Batygin, Konstantin; Fulton, Benjamin James; Burrows, Adam Seth; Fortney, Jonathan J.

    2016-01-01

    HAT-P-13b is a Jupiter-mass transiting exoplanet that has settled onto a stable, short-period, and mildly eccentric orbit due to the action of tidal dissipation and perturbations from a second, highly eccentric, outer companion. Due to the special orbital configuration of the HAT-P-13 system, the magnitude of HAT-P-13b's eccentricity is in part dictated by its Love number, i.e. the degree of central mass concentration in its interior. We can therefore directly constrain the fraction of HAT-P-13b's mass contained in its core by measuring its orbital eccentricity. This method offers considerable advantages over the standard approach of inferring core size based on mass and radius measurements alone. In this study we derive new constraints on the value of HAT-P-13b's eccentricity by observing two secondary eclipses of HAT-P-13b with the Infrared Array Camera on board the Spitzer Space Telescope. We fit the measured secondary eclipse times simultaneously with radial velocity measurements and find that the eccentricity of HAT-P-13b is 0.00696 ± 0.00096. We then use octupole-order secular perturbation theory to find that the corresponding Love number is 0.31 (+0.11, -0.05). Applying structural evolution models, we then find, with 68% confidence, that the core mass lies between 0-25 Earth masses, with a most likely value of the core mass of 11 Earth masses. This is the tightest constraint, to date, on the core mass of an exoplanet. We also compare the measured secondary eclipse depths, in the 3.6 and 4.5 micron bands, to the predictions of a suite of atmosphere models and find that the depths are best matched by models with a dayside temperature inversion and relatively efficient day-night circulation.

  13. Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo.

    PubMed Central

    Balasegaram, Manica; Harris, Steve; Checchi, Francesco; Hamel, Catherine; Karunakara, Unni

    2006-01-01

    OBJECTIVE: In 2002-03, the Republic of the Congo increased the threshold separating stage 1 and 2 cases of human African trypanosomiasis (HAT) from a cerebrospinal fluid (CSF) white cell count of 5 cells/mm(3) to 10 cells/mm(3). We aimed to assess whether the increased threshold of 10 cells/mm(3) is a safe indicator of stage 2 disease. METHODS: We assessed patients treated for stage 1 HAT caused by Trypanosoma brucei gambiense in the Republic of the Congo between April 2001 and April 2005. Patients with 0-10 cells/mm(3) in CSF were classed as stage 1 and treated with pentamidine. Patients with CSF of > 10 cells/mm(3) were classed as stage 2 and treated with either melarsoprol or eflornithine. We did a retrospective analysis of all patients treated after the September 2002 increase in threshold for classification of HAT disease stage 2, and who were eligible for at least 1 year of follow-up. Primary outcome was survival without death or relapse within 1 year of discharge. Risk factors for treatment failure, in particular CSF white cell count on diagnosis, were assessed. FINDINGS: Between September 2002 to April 2004, 692 patients eligible for our analysis were treated with pentamidine. All were discharged alive. Relapse rate was 5% (n = 33). The only identified risk factor for relapse was a CSF white cell count of 6-10 cells/mm(3) rather than 0-5 cells/mm(3) (adjusted hazard ratio 3.27 (95% confidence interval, 1.52-7.01); P = 0.002). CONCLUSION: A threshold of 5 white cells/mm(3) in CSF is safer than 10 cells/mm(3) to determine stage 2 HAT and reduce risk of relapse. PMID:17128357

  14. HAT-P-11b: A SUPER-NEPTUNE PLANET TRANSITING A BRIGHT K STAR IN THE KEPLER FIELD

    SciTech Connect

    Bakos, G. A.; Torres, G.; Pal, A.; Hartman, J.; Noyes, R. W.; Latham, D. W.; Sasselov, D. D.; Sipocz, B.; Esquerdo, G. A.; Kovacs, Gabor; Fernandez, J.; Kovacs, Geza; Moor, A.; Fischer, D. A.; Isaacson, H.; Johnson, J. A.; Marcy, G. W.; Howard, A.; Butler, R. P.; Vogt, S.

    2010-02-20

    We report on the discovery of HAT-P-11b, the smallest radius transiting extrasolar planet (TEP) discovered from the ground, and the first hot Neptune discovered to date by transit searches. HAT-P-11b orbits the bright (V = 9.587) and metal rich ([Fe/H] = +0.31 +- 0.05) K4 dwarf star GSC 03561-02092 with P = 4.8878162 +- 0.0000071 days and produces a transit signal with depth of 4.2 mmag, the shallowest found by transit searches that is due to a confirmed planet. We present a global analysis of the available photometric and radial velocity (RV) data that result in stellar and planetary parameters, with simultaneous treatment of systematic variations. The planet, like its near-twin GJ 436b, is somewhat larger than Neptune (17 M{sub +}, 3.8 R{sub +}) both in mass M{sub p} = 0.081 +- 0.009 M{sub J}(25.8 +- 2.9 M{sub +}) and radius R{sub p} = 0.422 +- 0.014 R{sub J}(4.73 +- 0.16 R{sub +}). HAT-P-11b orbits in an eccentric orbit with e = 0.198 +- 0.046 and omega = 355.{sup 0}2 +- 17.{sup 0}3, causing a reflex motion of its parent star with amplitude 11.6 +- 1.2 m s{sup -1}, a challenging detection due to the high level of chromospheric activity of the parent star. Our ephemeris for the transit events is T{sub c} = 2454605.89132 +- 0.00032 (BJD), with duration 0.0957 +- 0.0012 days, and secondary eclipse epoch of 2454608.96 +- 0.15 days (BJD). The basic stellar parameters of the host star are M{sub *} = 0.809{sup +0.020}{sub -0.027} M{sub sun}, R{sub *} = 0.752 +- 0.021 R{sub sun}, and T{sub eff*} = 4780 +- 50 K. Importantly, HAT-P-11 will lie on one of the detectors of the forthcoming Kepler mission; this should make possible fruitful investigations of the detailed physical characteristic of both the planet and its parent star at unprecedented precision. We discuss an interesting constraint on the eccentricity of the system by the transit light curve and stellar parameters. This will be particularly useful for eccentric TEPs with low-amplitude RV variations in Kepler

  15. Hydrologic Impacts of Fuel-Reduction Treatments in the Hat and Burney Creek Basin

    NASA Astrophysics Data System (ADS)

    Gaffney, R.; Tyler, S. W.; Wheelock, S.; Grant, G.; Nadler, C.; Sladek, C.; Young, D.; Adkins, P.

    2014-12-01

    Fuel-reduction treatments are commonly employed throughout the western United States to improve forest health and/or decrease the risk of wildland fires. Periods of prolonged drought and high temperatures increase both the risk of wildland fires and the stress on water resources. Forest managers may mitigate the risk of wildland fires by increasing fuel-reduction treatments but the subsequent effect on forest hydrology and water resources is not well understood. Of particularly interest to water resources is the effect on snow pack accumulation and melt timing, which is impacted by forest cover. As part of a Comprehensive Forest Landscape Restoration Program (CFLRP), four sites were selected in the Hat Creek Basin of Lassen National Forest to study the hydrologic effects of two common fuel-reduction strategies, forest thinning and group selection. During the 2013/2014 winter, California experienced a significant drought, including a near-absence of continuous snow cover. Therefore, the effect on snow accumulation and melt timing during the 13/14 winter was not directly measured. However, significant deviations in solar radiation, wind speed, and solar moisture were observed in the data, suggesting fuel reduction treatments will have a tangible effect of snow pack and forest hydrology. Further work to examine the relationship between forest cover, fuel-treatments, and basin hydrology includes the analysis of historic stream flow data and the development of a hydro-ecological model for the basin.

  16. STARSPOTS, SPIN-ORBIT MISALIGNMENT, AND ACTIVE LATITUDES IN THE HAT-P-11 EXOPLANETARY SYSTEM

    SciTech Connect

    Sanchis-Ojeda, Roberto; Winn, Joshua N.

    2011-12-10

    We present the analysis of four months of Kepler photometry of the K4V star HAT-P-11, including 26 transits of its 'super-Neptune' planet. The transit data exhibit numerous anomalies which we interpret as passages of the planet over dark starspots. These spot-crossing anomalies preferentially occur at two specific phases of the transit. These phases can be understood as the intersection points between the transit chord and the active latitudes of the host star, where starspots are most abundant. Based on the measured characteristics of spot-crossing anomalies and previous observations of the Rossiter-McLaughlin effect, we find two solutions for the stellar obliquity {psi} and active latitude l: either {psi} = 106{sup +15}{sub -11} and l = 19.7{sup +1.5}{sub -2.2}, or {psi} = 97{sup +8}{sub -4} and l = 67{sup +2}{sub -4} (all in degrees). If the active latitude changes with time analogous to the 'butterfly diagram' of the Sun's activity cycle, future observations should reveal changes in the preferred phases of spot-crossing anomalies.

  17. HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani.

    PubMed

    Kumar, Devanand; Saha, Swati

    2015-06-23

    Histone modifications impact various processes. In examining histone acetyltranferase HAT3 of Leishmania donovani, we find elimination of HAT3 causes decreased cell viability due to defects in histone deposition, and aberrant cell cycle progression pattern. HAT3 associates with proliferating cell nuclear antigen (PCNA), helping load PCNA onto chromatin in proliferating cells. HAT3-nulls show heightened sensitivity to UV radiation. Following UV exposure, PCNA cycles off/on chromatin only in cells expressing HAT3. Inhibition of the ubiquitin-proteasome pathway prior to UV exposure allows accumulation of chromatin-bound PCNA, and reveals that HAT3-nulls are deficient in PCNA monoubiquitination as well as polyubiquitination. While poor monoubiquitination of PCNA may adversely affect translesion DNA synthesis-based repair processes, polyubiquitination deficiencies may result in continued retention of chromatin-bound PCNA, leading to genomic instability. On suppressing the proteasome pathway we also find that HAT3 mediates PCNA acetylation in response to UV. HAT3-mediated PCNA acetylation may serve as a flag for PCNA ubiquitination, thus aiding DNA repair. While PCNA acetylation has previously been linked to its degradation following UV exposure, this is the first report linking a HAT-mediated PCNA acetylation to PCNA monoubiquitination. These findings add a new dimension to our knowledge of the mechanisms regulating PCNA ubiquitination post-UV exposure in eukaryotes.

  18. HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani

    PubMed Central

    Kumar, Devanand; Saha, Swati

    2015-01-01

    Histone modifications impact various processes. In examining histone acetyltranferase HAT3 of Leishmania donovani, we find elimination of HAT3 causes decreased cell viability due to defects in histone deposition, and aberrant cell cycle progression pattern. HAT3 associates with proliferating cell nuclear antigen (PCNA), helping load PCNA onto chromatin in proliferating cells. HAT3-nulls show heightened sensitivity to UV radiation. Following UV exposure, PCNA cycles off/on chromatin only in cells expressing HAT3. Inhibition of the ubiquitin-proteasome pathway prior to UV exposure allows accumulation of chromatin-bound PCNA, and reveals that HAT3-nulls are deficient in PCNA monoubiquitination as well as polyubiquitination. While poor monoubiquitination of PCNA may adversely affect translesion DNA synthesis-based repair processes, polyubiquitination deficiencies may result in continued retention of chromatin-bound PCNA, leading to genomic instability. On suppressing the proteasome pathway we also find that HAT3 mediates PCNA acetylation in response to UV. HAT3-mediated PCNA acetylation may serve as a flag for PCNA ubiquitination, thus aiding DNA repair. While PCNA acetylation has previously been linked to its degradation following UV exposure, this is the first report linking a HAT-mediated PCNA acetylation to PCNA monoubiquitination. These findings add a new dimension to our knowledge of the mechanisms regulating PCNA ubiquitination post-UV exposure in eukaryotes. PMID:25948582

  19. Phylogenetic and Functional Characterization of the hAT Transposon Superfamily

    PubMed Central

    Arensburger, Peter; Hice, Robert H.; Zhou, Liqin; Smith, Ryan C.; Tom, Ariane C.; Wright, Jennifer A.; Knapp, Joshua; O'Brochta, David A.; Craig, Nancy L.; Atkinson, Peter W.

    2011-01-01

    Transposons are found in virtually all organisms and play fundamental roles in genome evolution. They can also acquire new functions in the host organism and some have been developed as incisive genetic tools for transformation and mutagenesis. The hAT transposon superfamily contains members from the plant and animal kingdoms, some of which are active when introduced into new host organisms. We have identified two new active hAT transposons, AeBuster1, from the mosquito Aedes aegypti and TcBuster from the red flour beetle Tribolium castaneum. Activity of both transposons is illustrated by excision and transposition assays performed in Drosophila melanogaster and Ae. aegypti and by in vitro strand transfer assays. These two active insect transposons are more closely related to the Buster sequences identified in humans than they are to the previously identified active hAT transposons, Ac, Tam3, Tol2, hobo, and Hermes. We therefore reexamined the structural and functional relationships of hAT and hAT-like transposase sequences extracted from genome databases and found that the hAT superfamily is divided into at least two families. This division is supported by a difference in target-site selections generated by active transposons of each family. We name these families the Ac and Buster families after the first identified transposon or transposon-like sequence in each. We find that the recently discovered SPIN transposons of mammals are located within the family of Buster elements. PMID:21368277

  20. [A novel hyperspectra absorption enhancing method based on morphological top-hat transformation].

    PubMed

    Li, Hui; Lin, Qi-zhong; Wang, Qin-jun; Liu, Qing-jie; Chen, Yu

    2010-09-01

    Hyperspectral characteristics analysis of ground features is the basis for applications of high-resolution imaging technology to ground target identification and ground features classification. Based on morphological multi-scale Top-Hat transformation, a novel spectral absorption enhancing algorithms was put forward, which enhanced spectral absorption features while maintaining shape features of the absorption peak bands. Eleven reflectance spectra of different mineral groups were chosen from the mineral spectral library of the United States Geological Survey (USGS), and we used a K-means clustering analysis on both the absorption-enhanced spectra and the original reflectance spectra. Results showed that, firstly, clustering groups of the absorption-enhanced spectra (AES) had better similarity within the same clustering group, and greater difference between different groups, furthermore, they were more consistent with the geological background of these minerals compared with clustering result of the original spectra (OS). Secondly, while all the original spectra were re-sampled to their ASTER spectra and the AES clustering result was displayed in the form of ASTER spectra of the minerals, we could easily describe both the representative spectral feature of each clustering group, and the typical spectral differences between every two groups. These fully demonstrate that the absorption-enhanced spectra have enhanced absorption features of the mineral spectra, and improved the separability of hyper-spectra. Accordingly, feature analysis based on absorption enhanced spectra can be used as reference for information extracting based on multi-spectral remote sensing image data, and it is a very useful method of hyperspectral analysis. PMID:21105412

  1. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Addendum D1

    SciTech Connect

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation for the US Department of Energy (DOE), Grand Junctions Project Office in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill Tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. The objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on- pile sampling was required to determine the depth of the 15-pCi/g Ra- 226 interface in an area where wind and water erosion has taken place.

  2. HATS-1b: THE FIRST TRANSITING PLANET DISCOVERED BY THE HATSouth SURVEY

    SciTech Connect

    Penev, K.; Bakos, G. A.; Hartman, J. D.; Csubry, Z.; Bayliss, D.; Zhou, G.; Conroy, P.; Jordan, A.; Suc, V.; Rabus, M.; Brahm, R.; Espinoza, N.; Mohler, M.; Mancini, L.; Henning, T.; Nikolov, N.; Csak, B.; Beky, B.; Noyes, R. W.; Buchhave, L.; and others

    2013-01-01

    We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V = 12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period of P Almost-Equal-To 3.4465 days, mass of M{sub p} Almost-Equal-To 1.86 M{sub J}, and radius of R{sub p} Almost-Equal-To 1.30 R{sub J}. The host star has a mass of 0.99 M{sub Sun} and radius of 1.04 R{sub Sun }. The discovery light curve of HATS-1b has near-continuous coverage over several multi-day timespans, demonstrating the power of using a global network of telescopes to discover transiting planets.

  3. Measurement of nonlinear index by a relay-imaged top-hat Z-scan technique

    SciTech Connect

    Shimada, T.; Kurnit, N.A.; Sheik-Bahae, M.

    1996-04-01

    Measurements of the nonlinear index of a number of optical materials of interest for the National Ignition Facility have been performed at 1,064 nm and 355 nm by a modified version of the ``top-hat`` technique and the results compared with the more standard gaussian-beam Z-scan technique. The top-hat technique has the advantages of higher sensitivity and smaller uncertainties introduced by beam-quality considerations. The authors have made what they feel to be an additional improvement by placing the defining aperture for the top hat at the front focal plane of the lens that focuses the beam into the sample and then reimaging the input aperture with a second lens onto a ccd camera. Reimaging eliminates diffraction fringes and provides a stationary image even for a wedged sample; recording the entire image permits minimization of spurious effects such as varying interference fringes.

  4. A Common Proper Motion Stellar Companion to HAT-P-7

    NASA Technical Reports Server (NTRS)

    Grady, Carol A.; McElwain, Michael W.; Narita, Norio; Takahashi, Yasuhiro H.; Kuzuhara, Masayuki; Hirano, Teruyuki; Suenaga, Takuya

    2012-01-01

    We report that HAT-P-7 has a common proper motion stellar companion. The companion is located at approx. 3.9 arcsec to the east and estimated as an M5.5V dwarf based on its colors. We also confirm the presence of the third companion, which was first reported by Winn et al. (2009), based on long-term radial velocity measurements. We revisit the migration mechanism of HAT-P-7b given the presence of those companions, and propose sequential Kozai migration as a likely scenario in this system. This scenario may explain the reason for an outlier in the discussion of the spin-orbit alignment timescale for HAT-P-7b by Albrecht et al. (2012).

  5. VizieR Online Data Catalog: Transit of HAT-P-5 (Southworth+, 2012)

    NASA Astrophysics Data System (ADS)

    Southworth, J.; Mancini, L.; Maxted, P. F. L.; Bruni, I.; Tregloan-Reed, J.; Barbieri, M.; Ruocco, N.; Wheatley, P. J.

    2013-01-01

    We observed one full transit of HAT-P-5 on the night of 2010 August 23, using the 2.2-m telescope and BUSCA imager at Calar Alto Astronomical Observatory. BUSCA uses dichroics to split the incoming light into four wavelength intervals, which traverse different arms of the instrument and are incident on to four CCDs. We observed two transits of HAT-P-5 in 2011 May and July, using BFOSC mounted on the 1.52-m G.D. Cassini Telescope at Loiano Observatory, Italy. (2 data files).

  6. Red Hat Enterprise Virtualization - KVM-based infrastructure services at BNL

    SciTech Connect

    Cortijo, D.

    2011-06-14

    Over the past 18 months, BNL has moved a large percentage of its Linux-based servers and services into a Red Hat Enterprise Virtualization (RHEV) environment. This presentation will address our approach to virtualization, critical decision points, and a discussion of our implementation. Specific topics will include an overview of hardware and software requirements, networking, and storage; discussion of the decision of Red Hat solution over competing products (VMWare, Xen, etc); details on some of the features of RHEV - both current and on their roadmap; Review of performance and reliability gains since deployment completion; path forward for RHEV at BNL and caveats and potential problems.

  7. Mercury in Connecticut and Long Island Sound: Impact of Historic Hatting Industries

    NASA Astrophysics Data System (ADS)

    Bronsther, R.; Welsh, P.; Varekamp, J. C.

    2004-05-01

    Wetlands in the northeastern region of the U.S.A. are mildly contaminated with Hg as a result of atmospheric deposition, with modern soil concentrations of several 100 ppb Hg. Connecticut was once considered the hat manufacturing capital of the world. A solution of Hg-nitrate was used in the felting process, and old hat factory sites have become point sources of Hg contamination. Surface soils in the former hatting town of Danbury have Hg soil concentration levels that well exceed Connecticut's residential soil remediation standard of 20 ppm. Sediments from the Still River, a small waterway that runs through Danbury and discharges into the Housatonic River, show locally Hg concentrations of several tens of ppm, Cores taken from marsh islands in the Housatonic River show elevated Hg concentrations as well, up to 5 ppm Hg. Sites in Norwalk, another former hatting town, and along the Norwalk River also show values of more than 5 ppm Hg. The old hat factory sites in both towns clearly serve as point sources for Hg contamination downstream. Cores taken from marshes in the Connecticut River, which drains no former hatting towns, had much lower Hg concentrations (up to ~500 ppb Hg). The Five Mile River marsh near Darien, CT has lower peak values than found in the sediments of the Housatonic and Norwalk River cores, but still slightly elevated (800 ppb Hg). The Hg from the hat-site point sources is ultimately entering Long Island Sound. High Hg levels are found in western Long Island Sound compared to the eastern section (up to 800 ppb Hg), which is the result of fine-grained sediment transport westwards in the Sound, and the release of Hg-bearing effluent from waste water treatment plants of New York City. The contaminated sediment output from the Housatonic and Norwalk Rivers also contributes to the elevated Hg levels in the western Sound and possibly the Five Mile River marshes. Cores taken from the Housatonic River and western Long Island Sound show also peak Hg

  8. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah

    SciTech Connect

    1993-02-01

    This document is a revision of the original Mexiacan Hat Remedial Action Plan (RAP) and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. This RAP has been developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Section 2.0 presents the EPA standards, including a discussion of their objectives. Section 3. 0 summarizes the present site characteristics and provides a definition of site-specific problems. Section 4.0 is the site design for the proposed action. Section 5.0 presents the water resources protection strategy. Section 6.0 summarizes the plan for ensuring health and safety protection for the surrounding community and the on- site workers. Section 7.0 lists the responsibilities of the project participants. Section 8.0 describes the features of the long-term surveillance and maintenance plan.

  9. A Progressive Black Top Hat Transformation Algorithm for Estimating Valley Volumes from DEM Data

    NASA Astrophysics Data System (ADS)

    Luo, W.; Pingel, T.; Heo, J.; Howard, A. D.

    2013-12-01

    The amount of valley incision and valley volume are important parameters in geomorphology and hydrology research, because they are related to the amount erosion (and thus the volume of sediments) and the amount of water needed to create the valley. This is not only the case for terrestrial research but also for planetary research as such figuring out how much water was on Mars. With readily available digital elevation model (DEM) data, the Black Top Hat (BTH) transformation, an image processing technique for extracting dark features on a variable background, has been applied to DEM data to extract valley depth and estimate valley volume. However, previous studies typically use one single structuring element size for extracting the valley feature and one single threshold value for removing noise, resulting in some finer features such as tributaries not being extracted and underestimation of valley volume. Inspired by similar algorithms used in LiDAR data analysis to separate above ground features and bare earth topography, here we propose a progressive BTH (PBTH) transformation algorithm, where the structuring elements size is progressively increased to extract valleys of different orders. In addition, a slope based threshold was introduced to automatically adjust the threshold values for structuring elements with different sizes. Connectivity and shape parameters of the masked regions were used to keep the long linear valleys while removing other smaller non-connected regions. Preliminary application of the PBTH to Grand Canyon and two sites on Mars has produced promising results. More testing and fine-tuning is in progress. The ultimate goal of the project is to apply the algorithm to estimate the volume of valley networks on Mars and the volume of water needed to form the valleys we observe today and thus infer the nature of the hydrologic cycle on early Mars. The project is funded by NASA's Mars Data Analysis program.

  10. Physical properties of the HAT-P-23 and WASP-48 planetary systems from multi-colour photometry

    NASA Astrophysics Data System (ADS)

    Ciceri, S.; Mancini, L.; Southworth, J.; Bruni, I.; Nikolov, N.; D'Ago, G.; Schröder, T.; Bozza, V.; Tregloan-Reed, J.; Henning, Th.

    2015-05-01

    Context. Accurate and repeated photometric follow-up observations of planetary transit events are important to precisely characterize the physical properties of exoplanets. A good knowledge of the main characteristics of the exoplanets is fundamental in order to trace their origin and evolution. Multi-band photometric observations play an important role in this process. Aims: By using new photometric data, we computed precise estimates of the physical properties of two transiting planetary systems at equilibrium temperatures of ~2000 K. Methods: We present new broadband, multi-colour photometric observations obtained using three small class telescopes and the telescope-defocussing technique. In particular we obtained 11 and 10 light curves covering 8 and 7 transits of HAT-P-23 and WASP-48, respectively. For each of the two targets, one transit event was simultaneously observed through four optical filters. One transit of WASP-48 b was monitored with two telescopes from the same observatory. The physical parameters of the systems were obtained by fitting the transit light curves with jktebop and from published spectroscopic measurements. Results: We have revised the physical parameters of the two planetary systems, finding a smaller radius for both HAT-P-23 b and WASP-48 b, Rb = 1.224 ± 0.037 RJup and Rb = 1.396 ± 0.051 RJup, respectively, than those measured in the discovery papers (Rb = 1.368 ± 0.090 RJup and Rb = 1.67 ± 0.10 RJup). The density of the two planets are higher than those previously published (ρb ~ 1.1 and ~0.3 ρjup for HAT-P-23 and WASP-48, respectively) hence the two hot Jupiters are no longer located in a parameter space region of highly inflated planets. An analysis of the variation of the planet's measured radius as a function of optical wavelength reveals flat transmission spectra within the experimental uncertainties. We also confirm the presence of the eclipsing contact binary NSVS-3071474 in the same field of view of WASP-48, for which

  11. Hexaazatriphenylene (HAT) derivatives: from synthesis to molecular design, self-organization and device applications.

    PubMed

    Segura, José L; Juárez, Rafael; Ramos, Mar; Seoane, Carlos

    2015-10-01

    Dipyrazino[2,3-f:2′,3′-h]quinoxaline also known as 1,4,5,8,9,12-hexaazatriphenylene (HAT) is an electron deficient, rigid, planar, aromatic discotic system with an excellent π–π stacking ability. Because it is one of the smallest two-dimensional N-containing polyheterocyclic aromatic systems, it has been used as the basic scaffold for larger 2D N-substituted polyheterocyclic aromatics. Furthermore, it is the building block of choice in a plethora of molecular, macromolecular and supramolecular systems for a variety of applications. This review is aimed to critically review the research performed during the almost three decades of research based on HAT from the synthetic, theoretical and application points of view. The design principles and synthetic strategies towards HAT derivatives will be established and their use in n-type semiconductors, sensors, nonlinear optical chromophores, liquid crystals, microporous polymers for energy storage and nano and microstructures will reveal the relevance of HAT as a basic scaffold in the areas of organic materials and nanoscience.

  12. WASP-12b AND HAT-P-8b are members of triple star systems

    SciTech Connect

    Bechter, Eric B.; Crepp, Justin R.; Matthews, Christopher T.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Johnson, John Asher; Hinkley, Sasha; Muirhead, Philip S.; Montet, Benjamin T.; Morton, Timothy D.; Howard, Andrew W.

    2014-06-10

    We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M {sub ☉} using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

  13. Towards top-hat spatial shaping of ultrafast laser beam based on Zernike polynomials

    NASA Astrophysics Data System (ADS)

    Mauclair, Cyril; Faure, Nicolas; Houzet, Julien

    2016-04-01

    Femtosecond laser micro machining of surfaces knows a gain of interest as it demonstrates efficient and precise processing with reduced side effects around the irradiated zone, and also because of the remarkable costs reduction and reliability improvements of nowadays commercially available sources. Controlling the intensity distribution spatially can offer a supplementary degree of flexibility and precision in achieving user-defined ablation spatial profile, drilling, cutting of materials or in-volume laser-induced modifications. In this scope, the possibility to generate a top-hat intensity distribution by spatially shaping the beam wavefront is studied in this work. An optimization of Zernike polynomials coefficients is conducted to numerically determine an adequate phase mask that shapes the laser intensity distribution following a targeted top hat distribution in the processing plane, usually at the focal length of a converging lens. The efficiency of the method is numerically investigated in the optimization by evaluation of the root mean square error (RMS) between the top-hat target and the calculated laser distribution in the far field. We numerically verify that acceptable top-hat beam shaping of various size can be achieved with a sufficient number of Zernike polynomials, opening the way to phase mask calculations adapted to the wavefront modulator ability to reproduce Zernike polynomials.

  14. HATS-5b: A TRANSITING HOT SATURN FROM THE HATSouth SURVEY

    SciTech Connect

    Zhou, G.; Bayliss, D.; Schmidt, B.; Penev, K.; Bakos, G. Á.; Hartman, J. D.; Csubry, Z.; Jordán, A.; Brahm, R.; Rabus, M.; Suc, V.; Espinoza, N.; Mancini, L.; Mohler, M.; Ciceri, S.; Henning, T.; Buchhave, L.; Béky, B.; Noyes, R. W.; Butler, R. P.; and others

    2014-06-01

    We report the discovery of HATS-5b, a transiting hot Saturn orbiting a G-type star, by the HATSouth survey. HATS-5b has a mass of M{sub p} ≈ 0.24 M {sub J}, radius of R{sub p} ≈ 0.91 R {sub J}, and transits its host star with a period of P ≈ 4.7634 days. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V-band magnitude of 12.6, mass of 0.94 M {sub ☉}, and radius of 0.87 R {sub ☉}. The relatively high scale height of HATS-5b and the bright, photometrically quiet host star make this planet a favorable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas giants and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas giant population.

  15. Children's Conception of Thermal Conduction--Or the Story of a Woollen Hat.

    ERIC Educational Resources Information Center

    Newell, Andrew; Ross, Keith

    1996-01-01

    Reports on discussions with a year 10-group, following their first lesson on heat energy transfer, that revealed they still had not realized that insulation acted as a barrier; instead they saw it as an active warming agent. Describes a teaching method based on a woollen hat that challenges their naive ideas. (Author/JRH)

  16. Automatic Semantic Activation of Embedded Words: Is There a ''Hat'' in ''That''

    ERIC Educational Resources Information Center

    Bowers, J.S.; Davis, C.J.; Hanley, D.A.

    2005-01-01

    Participants semantically categorized target words that contain subsets (Experiment 1; e.g., target=hatch, subset=hat) or that are parts of supersets (Experiment 2; e.g., target=bee, superset=beer). In both experiments, the targets were categorized in a congruent condition (in which the subset-superset was associated with the same response, e.g.,…

  17. Six Thinking Hats and Social Workers' Innovative Competence: An Experimental Study

    ERIC Educational Resources Information Center

    Azeez, Razaq Olugbenga

    2016-01-01

    Employees, no doubt, are the main force in organizations, and their innovative behaviours are vital for outcome efficacy. Innovative organisations, therefore, need creative employees who generate new ideas for product or process of innovation. This study investigated the effect of six thinking hats creativity technique on innovative competence of…

  18. Beyond Pilgrim Hats and Turkey Hands: Using Thanksgiving to Promote Citizenship and Activism

    ERIC Educational Resources Information Center

    Christie, Erica M.; Montgomery, Sarah E.

    2010-01-01

    In many elementary classrooms, Thanksgiving is celebrated by donning homemade Pilgrim hats, grocery bag vests, and colorful construction-paper headdresses, as students join together to reenact the "first" Thanksgiving with a mock feast. Students compose journal entries on the topic, "what I am thankful for." These typical Thanksgiving activities,…

  19. WASP-12b and HAT-P-8b are Members of Triple Star Systems

    NASA Astrophysics Data System (ADS)

    Bechter, Eric B.; Crepp, Justin R.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Hinkley, Sasha; Muirhead, Philip S.; Johnson, John Asher; Howard, Andrew W.; Montet, Benjamin T.; Matthews, Christopher T.; Morton, Timothy D.

    2014-06-01

    We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M ⊙ using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

  20. Isolation and characterization of Vibrio cholerae isolates from seafood in Hat Yai City, Songkhla, Thailand.

    PubMed

    Preeprem, Sutima; Mittraparp-arthorn, Pimonsri; Bhoopong, Phuangthip; Vuddhakul, Varaporn

    2014-11-01

    Seafood has been identified as an important source of Vibrio cholerae in Thailand, especially in the Southern coastal region. In this study, we isolated and characterized V. cholerae from seafood obtained from several markets in Hat Yai city, Southern Thailand. A total of 100 V. cholerae isolates were obtained from 55 of 125 seafood samples. The dominant serotype was non-O1/non-O139. Polymerase chain reaction (PCR) analysis was used to detect the presence of pathogenesis-related genes. The stn/sto and hlyA El Tor virulence genes were detected in 20% and 96% of the isolates, respectively. None of the isolates were positive for the ctxA, tcpA, zot, and ace genes. Only 6% of the isolates carried the T3SS gene (vcsV2); however, the majority of the isolates (96%) carried the T6SS gene (vasH). Representative isolates (n=35) that exhibited various virulence gene patterns were randomly selected and analyzed for their hemolytic activity, antibiotic susceptibility, biofilm formation, and genotype. Hemolytic activity using sheep red blood cells was detected in only one of the hlyA-negative isolates. Apart from ampicillin, all isolates were pansusceptible to five test antibiotics. Biofilm production was observed in most of the isolates, and there was no difference in the presence of a biofilm between the smooth and rugose isolates. Using the enterobacterial repetitive intergenic consensus-PCR method, clonal relationships were observed among the isolates that exhibited identical virulence gene patterns.

  1. Dynamical Constraints on the Core Mass of Hot Jupiter HAT-P-13b

    NASA Astrophysics Data System (ADS)

    Buhler, Peter B.; Knutson, Heather A.; Batygin, Konstantin; Fulton, Benjamin J.; Fortney, Jonathan J.; Burrows, Adam; Wong, Ian

    2016-04-01

    HAT-P-13b is a Jupiter-mass transiting exoplanet that has settled onto a stable, short-period, and mildly eccentric orbit as a consequence of the action of tidal dissipation and perturbations from a second, highly eccentric, outer companion. Owing to the special orbital configuration of the HAT-P-13 system, the magnitude of HAT-P-13b's eccentricity (eb) is in part dictated by its Love number ({k}{2b}), which is in turn a proxy for the degree of central mass concentration in its interior. Thus, the measurement of eb constrains {k}{2b} and allows us to place otherwise elusive constraints on the mass of HAT-P-13b's core (Mcore,b). In this study we derive new constraints on the value of eb by observing two secondary eclipses of HAT-P-13b with the Infrared Array Camera on board the Spitzer Space Telescope. We fit the measured secondary eclipse times simultaneously with radial velocity measurements and find that eb = 0.00700 ± 0.00100. We then use octupole-order secular perturbation theory to find the corresponding {k}{2b}={0.31}-0.05+0.08. Applying structural evolution models, we then find, with 68% confidence, that Mcore,b is less than 25 Earth masses (M⊕). The most likely value is Mcore,b = 11 M⊕, which is similar to the core mass theoretically required for runaway gas accretion. This is the tightest constraint to date on the core mass of a hot Jupiter. Additionally, we find that the measured secondary eclipse depths, which are in the 3.6 and 4.5 μm bands, best match atmospheric model predictions with a dayside temperature inversion and relatively efficient day-night circulation.

  2. Atmospheric circulation of eccentric hot Jupiter HAT-P-2B

    SciTech Connect

    Lewis, Nikole K.; Showman, Adam P.; Fortney, Jonathan J.; Knutson, Heather A.; Marley, Mark S.

    2014-11-10

    The hot Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse events that results in significant variations in the timing and magnitude of the peak of the planetary flux compared with models in which TiO/VO are omitted from the opacity tables. We find that no one single atmospheric model can reproduce the recently observed full orbit phase curves at 3.6, 4.5 and 8.0 μm, which is likely due to a chemical process not captured by our current atmospheric models for HAT-P-2b. Further modeling and observational efforts focused on understanding the chemistry of HAT-P-2b's atmosphere are needed and could provide key insights into the interplay between radiative, dynamical, and chemical processes in a wide range of exoplanet atmospheres.

  3. Atmospheric Circulation of Eccentric Hot Jupiter HAT-P-2b

    NASA Astrophysics Data System (ADS)

    Lewis, Nikole K.; Showman, Adam P.; Fortney, Jonathan J.; Knutson, Heather A.; Marley, Mark S.

    2014-11-01

    The hot Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse events that results in significant variations in the timing and magnitude of the peak of the planetary flux compared with models in which TiO/VO are omitted from the opacity tables. We find that no one single atmospheric model can reproduce the recently observed full orbit phase curves at 3.6, 4.5 and 8.0 μm, which is likely due to a chemical process not captured by our current atmospheric models for HAT-P-2b. Further modeling and observational efforts focused on understanding the chemistry of HAT-P-2b's atmosphere are needed and could provide key insights into the interplay between radiative, dynamical, and chemical processes in a wide range of exoplanet atmospheres.

  4. Dynamical Constraints on the Core Mass of Hot Jupiter HAT-P-13b

    NASA Astrophysics Data System (ADS)

    Buhler, Peter B.; Knutson, Heather A.; Batygin, Konstantin; Fulton, Benjamin J.; Fortney, Jonathan J.; Burrows, Adam; Wong, Ian

    2016-04-01

    HAT-P-13b is a Jupiter-mass transiting exoplanet that has settled onto a stable, short-period, and mildly eccentric orbit as a consequence of the action of tidal dissipation and perturbations from a second, highly eccentric, outer companion. Owing to the special orbital configuration of the HAT-P-13 system, the magnitude of HAT-P-13b's eccentricity (eb) is in part dictated by its Love number ({k}{2b}), which is in turn a proxy for the degree of central mass concentration in its interior. Thus, the measurement of eb constrains {k}{2b} and allows us to place otherwise elusive constraints on the mass of HAT-P-13b's core (Mcore,b). In this study we derive new constraints on the value of eb by observing two secondary eclipses of HAT-P-13b with the Infrared Array Camera on board the Spitzer Space Telescope. We fit the measured secondary eclipse times simultaneously with radial velocity measurements and find that eb = 0.00700 ± 0.00100. We then use octupole-order secular perturbation theory to find the corresponding {k}{2b}={0.31}-0.05+0.08. Applying structural evolution models, we then find, with 68% confidence, that Mcore,b is less than 25 Earth masses (M⊕). The most likely value is Mcore,b = 11 M⊕, which is similar to the core mass theoretically required for runaway gas accretion. This is the tightest constraint to date on the core mass of a hot Jupiter. Additionally, we find that the measured secondary eclipse depths, which are in the 3.6 and 4.5 μm bands, best match atmospheric model predictions with a dayside temperature inversion and relatively efficient day–night circulation.

  5. Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; von Essen, C.; Weingrill, J.; Strassmeier, K. G.; Ribas, I.; Carroll, T. A.; Herrero, E.; Granzer, T.; Claret, A.; Schwope, A.

    2015-08-01

    Context. Transiting highly inflated giant planets offer the possibility of characterizing their atmospheres. A fraction of the starlight passes through the high-altitude layers of the planetary atmosphere during transit. The resulting absorption is expected to be wavelength dependent for cloud-free atmospheres with an amplitude of up to 10-3 of the stellar flux, while a high-altitude cloud deck would cause a gray opacity. Aims: We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. Methods: A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 Å. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 Å width. We analyzed these spectral light curves for chromatic variations of transit depth. Results: The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio of 0.1390 ± 0.0012 and an inclination of 88.89 ± 0.32 deg. After a re-analysis of published data, we refine the orbital period to 4.0087844 ± 0.0000015 days. We obtain a flat transmission spectrum without significant additional absorption at any wavelength or any slope. However, our accuracy is not sufficient to significantly rule out the presence of a pressure-broadened sodium feature. Our photometric monitoring campaign allowed for an estimate of the stellar rotation period of 35.5 ± 2.5 days and an improved age

  6. HAT-P-32b and HAT-P-33b: Two Highly Inflated Hot Jupiters Transiting High-jitter Stars

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bakos, G. Á.; Torres, G.; Latham, D. W.; Kovács, Géza; Béky, B.; Quinn, S. N.; Mazeh, T.; Shporer, A.; Marcy, G. W.; Howard, A. W.; Fischer, D. A.; Johnson, J. A.; Esquerdo, G. A.; Noyes, R. W.; Sasselov, D. D.; Stefanik, R. P.; Fernandez, J. M.; Szklenár, T.; Lázár, J.; Papp, I.; Sári, P.

    2011-11-01

    We report the discovery of two exoplanets transiting high-jitter stars. HAT-P-32b orbits the bright V = 11.289 late-F-early-G dwarf star GSC 3281-00800, with a period P = 2.150008 ± 0.000001 d. The stellar and planetary masses and radii depend on the eccentricity of the system, which is poorly constrained due to the high-velocity jitter (~80 m s-1). Assuming a circular orbit, the star has a mass of 1.16 ± 0.04 M ⊙ and radius of 1.22 ± 0.02 R ⊙, while the planet has a mass of 0.860 ± 0.164 M J and a radius of 1.789 ± 0.025 R J. The second planet, HAT-P-33b, orbits the bright V = 11.188 late-F dwarf star GSC 2461-00988, with a period P = 3.474474 ± 0.000001 d. As for HAT-P-32, the stellar and planetary masses and radii of HAT-P-33 depend on the eccentricity, which is poorly constrained due to the high jitter (~50 m s-1). In this case, spectral line bisector spans (BSs) are significantly anti-correlated with the radial velocity residuals, and we are able to use this correlation to reduce the residual rms to ~35 m s-1. We find that the star has a mass of 1.38 ± 0.04 M ⊙ and a radius of 1.64 ± 0.03 R ⊙ while the planet has a mass of 0.762 ± 0.101 M J and a radius of 1.686 ± 0.045 R J for an assumed circular orbit. Due to the large BS variations exhibited by both stars we rely on detailed modeling of the photometric light curves to rule out blend scenarios. Both planets are among the largest radii transiting planets discovered to date. Based in part on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology. Keck time has been granted by NOAO (A285Hr, A146Hr, A201Hr, A289Hr), NASA (N128Hr, N145Hr, N049Hr, N018Hr, N167Hr, N029Hr), and the NOAO Gemini/Keck time-exchange program (G329Hr).

  7. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    PubMed

    Bulf, Hermann; Valenza, Eloisa; Turati, Chiara

    2013-01-01

    Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase) and face recognition (i.e. test phase). An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1). Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2). Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3). Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment.

  8. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Day Circular Orbit

    NASA Astrophysics Data System (ADS)

    Brahm, R.; Jordán, A.; Bakos, G. Á.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lázár, J.; Papp, I.; Sári, P.

    2016-04-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V = 12.4) G-type ({M}\\star = 1.131+/- 0.030 {M}⊙ , {R}\\star = {1.091}-0.046+0.070 {R}⊙ ) metal-rich ([Fe/H] = +0.3 dex) host star in a circular orbit with a period of P = 16.2546 days. HATS-17b has a very compact radius of 0.777+/- 0.056 {R}{{J}} given its Jupiter-like mass of 1.338+/- 0.065 {M}{{J}}. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17 will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla and with the 3.9 m AAT in Siding Spring Observatory. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope. Based on observations taken with the HARPS spectrograph (ESO 3.6 m telescope at La Silla) under programme 097.C-0571.

  9. Exploring the unlimited possibilities of modular aspheric Gauss to top-hat beam shaping

    NASA Astrophysics Data System (ADS)

    Möhl, Anna; Fuchs, Ulrike

    2016-06-01

    Beam shaping is a field of research with growing importance. Therefore, a new refractive beam shaping system is presented. The knowledge gained from analyzing patent systems was used to derive our own improved design. It is compared to a patent system, and some selected results are presented in this work. Furthermore, possibilities to scale the entrance and exit beam diameters with the help of SPA™ Beam Expander Kit and SPA™ AspheriColl (both from asphericon GmbH, Jena, Germany) are shown, so that a modular top-hat generation is achievable. Additionally, the large spectral range in which the beam shaping system is applicable is demonstrated, and it is demonstrated how the beam shaping system can be used to improve the performance of other optical elements that require a top-hat beam profile.

  10. High-power Er:YAG laser with quasi-top-hat output beam.

    PubMed

    Kim, J W; Mackenzie, J I; Hayes, J R; Clarkson, W A

    2012-05-01

    A simple method for simultaneously exciting the fundamental (TEM00) transverse mode and first order Laguerre-Gaussian (LG01) donut mode in an end-pumped solid-state laser to yield a quasi-top-hat output beam is reported. This approach has been applied to an Er:YAG laser, in-band pumped by an Er,Yb fiber laser, yielding 9.6 W of continuous-wave output at 1645 nm in a top-hat-like beam with beam propagation factor (M2)<2.1 for 24 W of incident pump power at 1532 nm. The corresponding slope efficiency with respect to incident pump power was 49%. The prospects of further scaling of output power and improved overall efficiency are considered.

  11. Kepler's optical phase curve of the exoplanet HAT-P-7b.

    PubMed

    Borucki, W J; Koch, D; Jenkins, J; Sasselov, D; Gilliland, R; Batalha, N; Latham, D W; Caldwell, D; Basri, G; Brown, T; Christensen-Dalsgaard, J; Cochran, W D; DeVore, E; Dunham, E; Dupree, A K; Gautier, T; Geary, J; Gould, A; Howell, S; Kjeldsen, H; Lissauer, J; Marcy, G; Meibom, S; Morrison, D; Tarter, J

    2009-08-01

    Ten days of photometric data were obtained during the commissioning phase of the Kepler mission, including data for the previously known giant transiting exoplanet HAT-P-7b. The data for HAT-P-7b show a smooth rise and fall of light from the planet as it orbits its star, punctuated by a drop of 130 +/- 11 parts per million in flux when the planet passes behind its star. We interpret this as the phase variation of the dayside thermal emission plus reflected light from the planet as it orbits its star and is occulted. The depth of the occultation is similar in photometric precision to the detection of a transiting Earth-size planet for which the mission was designed.

  12. Origin of the Napoleon's hat nebula around SN1987A and implications for the progenitor

    NASA Astrophysics Data System (ADS)

    Podsiadlowski, Ph.; Fabian, A. C.; Stevens, I. R.

    1991-11-01

    A simple geometrical model for the emission nebula around SN1987A, whose morphology has been likened to Napoleon's hat, is presented. The model consists of a ring and a truncated double cone. When the effects of light travel time are included, the model reproduces the important topological structures of the nebula and makes detailed quantitative predictions for its future appearance. In particular, the hat-shaped northern rim is simply explained as the interaction of the light front with the northern cone. To explain the origin of the double cone, it is argued that the progenitor of SN1987A was in a binary system: its strong wind, colliding with a weaker wind from the companion star, created an asymptotic shock surface that was spread out into the required geometry by the rotation of the binary.

  13. Kepler's optical phase curve of the exoplanet HAT-P-7b.

    PubMed

    Borucki, W J; Koch, D; Jenkins, J; Sasselov, D; Gilliland, R; Batalha, N; Latham, D W; Caldwell, D; Basri, G; Brown, T; Christensen-Dalsgaard, J; Cochran, W D; DeVore, E; Dunham, E; Dupree, A K; Gautier, T; Geary, J; Gould, A; Howell, S; Kjeldsen, H; Lissauer, J; Marcy, G; Meibom, S; Morrison, D; Tarter, J

    2009-08-01

    Ten days of photometric data were obtained during the commissioning phase of the Kepler mission, including data for the previously known giant transiting exoplanet HAT-P-7b. The data for HAT-P-7b show a smooth rise and fall of light from the planet as it orbits its star, punctuated by a drop of 130 +/- 11 parts per million in flux when the planet passes behind its star. We interpret this as the phase variation of the dayside thermal emission plus reflected light from the planet as it orbits its star and is occulted. The depth of the occultation is similar in photometric precision to the detection of a transiting Earth-size planet for which the mission was designed. PMID:19661420

  14. VizieR Online Data Catalog: Transmission spectroscopy of HAT-P-32b (Mallonn+, 2016)

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; Strassmeier, K. G.

    2016-05-01

    A set of 62 simultaneous photometric light curves from 3300 to 10000Å of a transit event of HAT-P-32b. The wavelength range of each light curve is ~100Å in average. The light curves cover about one hour pre-transit, the transit event, and about 1 hour post-transit. Observations have been taken with MODS at LBT in multi-object mode. Light curves are given in differential magnitudes. (2 data files).

  15. HAT-P-26b: A Neptune-mass Exoplanet with Primordial Solar Heavy Element Abundance

    NASA Astrophysics Data System (ADS)

    Wakeford, Hannah; Sing, David; Deming, Drake; Kataria, Tiffany; Lopez, Eric

    2016-10-01

    A trend in giant planet mass and atmospheric heavy elemental abundance was first noted last century from observations of planets in our own solar system. These four data points from Jupiter, Saturn, Uranus, and Neptune have served as a corner stone of planet formation theory. Here we add another point in the mass-metallicity trend from a detailed observational study of the extrasolar planet HAT-P-26b, which inhabits the critical mass regime near Neptune and Uranus. Neptune-sized worlds are among the most common planets in our galaxy and frequently exist in orbital periods very different from that of our own solar system ice giants. Atmospheric studies are the principal window into these worlds, and thereby into their formation and evolution, beyond those of our own solar system. Using the Hubble Space Telescope and Spitzer, from the optical to the infrared, we conducted a detailed atmospheric study of the Neptune-mass exoplanet HAT-P-26b over 0.5 to 4.5 μm. We detect prominent H2O absorption at 1.4 μm to 525 ppm in the atmospheric transmission spectrum. We determine that HAT-P-26b's atmosphere is not rich in heavy elements (≈1.8×solar), which goes distinctly against the solar system mass-metallicity trend. This likely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its disk lifetime with little contamination from metal-rich planetesimals.

  16. The diversification and activity of hAT transposons in Musa genomes.

    PubMed

    Menzel, Gerhard; Heitkam, Tony; Seibt, Kathrin M; Nouroz, Faisal; Müller-Stoermer, Manuela; Heslop-Harrison, John S; Schmidt, Thomas

    2014-12-01

    Sequencing of plant genomes often identified the hAT superfamily as the largest group of DNA transposons. Nevertheless, detailed information on the diversity, abundance and chromosomal localization of plant hAT families are rare. By in silico analyses of the reference genome assembly and bacterial artificial chromosome (BAC) sequences, respectively, we performed the classification and molecular characterization of hAT transposon families in Musa acuminata. Musa hAT transposons are organized in three families designated MuhAT I, MuhAT II and MuhAT III. In total, 70 complete autonomous elements of the MuhAT I and MuhAT II families were detected, while no autonomous MuhAT III transposons were found. Based on the terminal inverted repeat (TIR)-specific sequence information of the autonomous transposons, 1722 MuhAT I- and MuhAT II-specific miniature inverted-repeat transposable elements (MuhMITEs) were identified. Autonomous MuhAT I and MuhAT II elements are only moderately abundant in the sections of the genus Musa, while the corresponding MITEs exhibit an amplification in Musa genomes. By fluorescent in situ hybridization (FISH), autonomous MuhAT transposons as well as MuhMITEs were localized in subtelomeric, most likely gene-rich regions of M. acuminata chromosomes. A comparison of homoeologous regions of M. acuminata and Musa balbisiana BACs revealed the species-specific mobility of MuhMITEs. In particular, the activity of MuhMITEs II showing transduplications of genomic sequences might indicate the presence of active MuhAT transposons, thus suggesting a potential role of MuhMITEs as modulators of genome evolution of Musa.

  17. A lower radius and mass for the transiting extrasolar planet HAT-P-8 b

    NASA Astrophysics Data System (ADS)

    Mancini, L.; Southworth, J.; Ciceri, S.; Fortney, J. J.; Morley, C. V.; Dittmann, J. A.; Tregloan-Reed, J.; Bruni, I.; Barbieri, M.; Evans, D. F.; D'Ago, G.; Nikolov, N.; Henning, Th.

    2013-03-01

    Context. The extrasolar planet HAT-P-8 b was thought to be one of the more inflated transiting hot Jupiters. Aims: By using new and existing photometric data, we computed precise estimates of the physical properties of the system. Methods: We present photometric observations comprising eleven light curves covering six transit events, obtained using five medium-class telescopes and telescope-defocussing technique. One transit was simultaneously obtained through four optical filters, and two transits were followed contemporaneously from two observatories. We modelled these and seven published datasets using the jktebop code. The physical parameters of the system were obtained from these results and from published spectroscopic measurements. In addition, we investigated the theoretically-predicted variation of the apparent planetary radius as a function of wavelength, covering the range 330-960 nm. Results: We find that HAT-P-8 b has a significantly lower radius (1.321 ± 0.037 RJup) and mass (1.275 ± 0.053 MJup) compared to previous estimates (1.50-0.06+0.08 R_{Jup} and 1.52-0.16+0.18 M_{Jup} respectively). We also detect a radius variation in the optical bands that, when compared with synthetic spectra of the planet, may indicate the presence of a strong optical absorber, perhaps TiO and VO gases, near the terminator of HAT-P-8 b. Conclusions: These new results imply that HAT-P-8 b is not significantly inflated, and that its position in the planetary mass-radius diagram is congruent with those of many other transiting extrasolar planets. Full Table 2 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/551/A11

  18. RSRM top hat cover simulator lightning test, volume 2. Appendix A: Resistance measurements. Appendix B: Lightning test data plots

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Resistance measurements are given in graphical for when a simulated lightning discharge strikes on an exposed top hat cover simulator. The test sequence was to measure the electric and magnetic fields induced inside a redesigned solid rocket motor case.

  19. Spitzer Secondary Eclipses of the Dense, Modestly-irradiated, Giant Exoplanet HAT-P-20b Using Pixel-level Decorrelation

    NASA Astrophysics Data System (ADS)

    Deming, Drake; Knutson, Heather; Kammer, Joshua; Fulton, Benjamin J.; Ingalls, James; Carey, Sean; Burrows, Adam; Fortney, Jonathan J.; Todorov, Kamen; Agol, Eric; Cowan, Nicolas; Desert, Jean-Michel; Fraine, Jonathan; Langton, Jonathan; Morley, Caroline; Showman, Adam P.

    2015-06-01

    HAT-P-20b is a giant metal-rich exoplanet orbiting a metal-rich star. We analyze two secondary eclipses of the planet in each of the 3.6 and 4.5 μm bands of Warm Spitzer. We have developed a simple, powerful, and radically different method to correct the intra-pixel effect for Warm Spitzer data, which we call pixel-level decorrelation (PLD). PLD corrects the intra-pixel effect very effectively, but without explicitly using—or even measuring—the fluctuations in the apparent position of the stellar image. We illustrate and validate PLD using synthetic and real data and comparing the results to previous analyses. PLD can significantly reduce or eliminate red noise in Spitzer secondary eclipse photometry, even for eclipses that have proven to be intractable using other methods. Our successful PLD analysis of four HAT-P-20b eclipses shows a best-fit blackbody temperature of 1134 ± 29 K, indicating inefficient longitudinal transfer of heat, but lacking evidence for strong molecular absorption. We find sufficient evidence for variability in the 4.5 μm band that the eclipses should be monitored at that wavelength by Spitzer, and this planet should be a high priority for James Webb Space Telescope spectroscopy. All four eclipses occur about 35 minutes after orbital phase 0.5, indicating a slightly eccentric orbit. A joint fit of the eclipse and transit times with extant RV data yields ecos ω =0.01352-0.00057+0.00054 and establishes the small eccentricity of the orbit to high statistical confidence. HAT-P-20b is another excellent candidate for orbital evolution via Kozai migration or other three-body mechanisms.

  20. A spin-orbit alignment for the hot Jupiter HATS-3b

    SciTech Connect

    Addison, B. C.; Tinney, C. G.; Wright, D. J.; Bayliss, D.

    2014-09-10

    We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of λ = 3° ± 25° was determined from spectroscopic measurements of the Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures >6250 K to have randomly distributed spin-orbit angles.

  1. HATS-4b: A dense hot Jupiter transiting a super metal-rich G star

    SciTech Connect

    Jordán, Andrés; Brahm, Rafael; Rabus, M.; Suc, V.; Espinoza, N.; Bakos, G. Á.; Penev, K.; Hartman, J. D.; Csubry, Z.; Bhatti, W.; De Val Borro, M.; Bayliss, D.; Zhou, G.; Mancini, L.; Mohler-Fischer, M.; Ciceri, S.; Csák, B.; Henning, T.; Sato, B.; Buchhave, L.; and others

    2014-08-01

    We report the discovery by the HATSouth survey of HATS-4b, an extrasolar planet transiting a V = 13.46 mag G star. HATS-4b has a period of P ≈ 2.5167 days, mass of M{sub p} ≈ 1.32 M {sub Jup}, radius of R{sub p} ≈ 1.02 R {sub Jup}, and density of ρ {sub p} = 1.55 ± 0.16 g cm{sup –3} ≈1.24 ρ{sub Jup}. The host star has a mass of 1.00 M {sub ☉}, a radius of 0.92 R {sub ☉}, and a very high metallicity [Fe/H]=0.43 ± 0.08. HATS-4b is among the densest known planets with masses between 1 and 2 M {sub J} and is thus likely to have a significant content of heavy elements of the order of 75 M {sub ⊕}. In this paper we present the data reduction, radial velocity measurements, and stellar classification techniques adopted by the HATSouth survey for the CORALIE spectrograph. We also detail a technique for simultaneously estimating vsin i and macroturbulence using high resolution spectra.

  2. iHAT: interactive hierarchical aggregation table for genetic association data.

    PubMed

    Heinrich, Julian; Vehlow, Corinna; Battke, Florian; Jäger, Günter; Weiskopf, Daniel; Nieselt, Kay

    2012-01-01

    In the search for single-nucleotide polymorphisms which influence the observable phenotype, genome wide association studies have become an important technique for the identification of associations between genotype and phenotype of a diverse set of sequence-based data. We present a methodology for the visual assessment of single-nucleotide polymorphisms using interactive hierarchical aggregation techniques combined with methods known from traditional sequence browsers and cluster heatmaps. Our tool, the interactive Hierarchical Aggregation Table (iHAT), facilitates the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings. Different color maps and aggregation strategies as well as filtering options support the user in finding correlations between sequences and metadata. Similar to other visualizations such as parallel coordinates or heatmaps, iHAT relies on the human pattern-recognition ability for spotting patterns that might indicate correlation or anticorrelation. We demonstrate iHAT using artificial and real-world datasets for DNA and protein association studies as well as expression Quantitative Trait Locus data.

  3. The refined physical parameters of transiting exoplanet system HAT-P-24

    NASA Astrophysics Data System (ADS)

    Wang, Xiao-Bin; Gu, Sheng-Hong; Collier Cameron, Andrew; Tan, Hong-Bo; Hui, Ho-Keung; Kwok, Chi-Tai; Yeung, Bill; Leung, Kam-Cheung

    2013-05-01

    The transiting exoplanet system HAT-P-24 was observed by using CCD cameras at Yunnan Observatory and Hokoon Astronomical Centre, China in 2010 and 2012. In order to enhance the signal to noise ratio of transit events, the observed data are corrected for systematic errors according to Collier Cameron et al.'s coarse de-correlation and Tamuz et al.'s SYSREM algorithms. Three new complete transit light curves are analyzed by means of the Markov chain Monte Carlo technique, and the new physical parameters of the system are derived. They are consistent with the old ones from the discovered paper except for a new larger radius Rp = 1.364 RJ of HAT-P-24b, which confirms its inflated nature. By combining the five available epochs of mid-transit derived from complete transit light curves, the orbital period of HAT-P-24b is refined to P = 3.3552479 d and no obvious transit timing variation signal can be found from these five transit events during 2010-2012.

  4. Detection of the Secondary Eclipse of Exoplanet HAT P-11b

    NASA Technical Reports Server (NTRS)

    Barry, R. K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We have successfully conducted secondary eclipse observations of exoplanet HAT-P-11b using the Spitzer Space Telescope. HAT-P-11b was, until very recently, the smallest transiting extrasolar planet yet found and one of only two known exo-Neptunes. We observed the system at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. A precise determination of the orbit phase for the secondary eclipse will also be of great utility for Kepler observations of this system at visible wavelengths.

  5. Image registration algorithm using Mexican hat function-based operator and grouped feature matching strategy.

    PubMed

    Jin, Feng; Feng, Dazheng

    2014-01-01

    Feature detection and matching are crucial for robust and reliable image registration. Although many methods have been developed, they commonly focus on only one class of image features. The methods that combine two or more classes of features are still novel and significant. In this work, methods for feature detection and matching are proposed. A Mexican hat function-based operator is used for image feature detection, including the local area detection and the feature point detection. For the local area detection, we use the Mexican hat operator for image filtering, and then the zero-crossing points are extracted and merged into the area borders. For the feature point detection, the Mexican hat operator is performed in scale space to get the key points. After the feature detection, an image registration is achieved by using the two classes of image features. The feature points are grouped according to a standardized region that contains correspondence to the local area, precise registration is achieved eventually by the grouped points. An image transformation matrix is estimated by the feature points in a region and then the best one is chosen through competition of a set of the transformation matrices. This strategy has been named the Grouped Sample Consensus (GCS). The GCS has also ability for removing the outliers effectively. The experimental results show that the proposed algorithm has high registration accuracy and small computational volume. PMID:24752223

  6. Reconstruction-by-Dilation and Top-Hat Algorithms for Contrast Enhancement and Segmentation of Microcalcifications in Digital Mammograms

    NASA Astrophysics Data System (ADS)

    Diaz, Claudia C.

    2007-11-01

    I present some results of contrast enhancement and segmentation of microcalcifications in digital mammograms. These mammograms were obtained from MIAS-minidatabase and using a CR to digitize images. White-top-hat and black-top-hat transformations were used to improve the contrast of images, while reconstruction-by-dilation algorithm was used to emphasize the microcalcifications over the tissues. Segmentation was done using different gradient matrices. These algorithms intended to show some details which were not evident in original images.

  7. Spin-orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES

    NASA Astrophysics Data System (ADS)

    Zhou, George; Latham, David W.; Bieryla, Allyson; Beatty, Thomas G.; Buchhave, Lars A.; Esquerdo, Gilbert A.; Berlind, Perry; Calkins, Michael L.

    2016-08-01

    We present Doppler tomographic analyses for the spectroscopic transits of KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host stars. These include analyses of archival Tillinghast Reflector Echelle Spectrograph (TRES) observations for KELT-7b, and a new TRES transit observation of HAT-P-56b. We report spin-orbit aligned geometries for KELT-7b (2.7° ± 0.6°) and HAT-P-56b (8° ± 2°). The host stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating planet-hosting stars known. We examine the tidal re-alignment model for the evolution of the spin-orbit angle in the context of the spin rates of these stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have been modified by star-planet tidal interactions, suggesting that the spin-orbit angle of systems around these hot stars may represent their primordial configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in supersynchronous, spin-orbit aligned states, where the rotation periods of the host stars are faster than the orbital periods of the planets.

  8. Investigation on Twisting and Side Wall Opening Occurring in Curved Hat Channel Products Made of High Strength Steel Sheets

    NASA Astrophysics Data System (ADS)

    Takamura, Masato; Fukui, Ayako; Yano, Hiroshi; Hama, Takayuki; Sunaga, Hideyuki; Makinouchi, Akitake; Asakawa, Motoo

    2011-08-01

    High strength steel sheets are becoming increasingly important for the weight reduction of automotive bodies to meet the requirements for reduced environmental impact. However, dimensional defects resulting from springback are serious issues, and effective methods of predicting and reducing such defects are necessary. In this study, we numerically and experimentally analyzed the mechanisms of dimensional inaccuracies caused by springback occurring in curved hat channel deep drawing products. The analysis was based on the static explicit FEM software "TP-STRUCT" (the solver part is known as "STAMP3D"). The results of the experiments and simulations similarly show that the twist angle is positive (right-hand system) when the drawing height is relatively large. We calculated the twist torque around the longitudinal axis using the stress distributions obtained by FE analysis. Through the investigation of twist torque and its transition during the drawing and die removal processes, we found that the negative torque generated by side wall opening occurring in the die removal process is the dominant factor of the positive twist. Knowing such mechanisms of twist in cases with a relatively large drawing height, we attempted to explore methods of reducing side wall opening by giving the side wall a stepped shape with the eventual aim of reducing twist. Consequently, we concluded that the stepped shape on the side wall has marked effects of reducing side wall opening, mainly through the elimination of bending-unbending effects on die shoulders, which was verified by observing the stress distribution obtained by FE analysis.

  9. Wear your hat: representational resistance in safer sex discourse.

    PubMed

    Nelson, S D

    1994-01-01

    Through an analysis of four posters used by the AIDS Action Committee of Massachusetts, this article asks how representation can effectively promote safer sex practices. The images under investigation have different targeted groups--one is aimed at African-American men, one at Latinas, and two at gay men. Using a frame-work that connects definitions of sex in the respective communities with differences surrounding gender, race, and class, the imagery is unpacked in order to expose the effects of safer sex representation. This essay then argues that the degree to which ingrained definitions of sex are challenged constitutes a determining factor in the success or failure of safer sex representations. PMID:7798606

  10. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    SciTech Connect

    Zhao, Ming; Wright, Jason T.; Curtis, Jason; O'Rourke, Joseph G.; Knutson, Heather A.; Ngo, Henry; Burrows, Adam; Fortney, Johnathan; Fulton, Benjamin J.; Baranec, Christoph; Riddle, Reed; Hinkley, Sasha; Law, Nicholas M.; Muirhead, Philip S.; Showman, Adam P.; Burruss, Rick

    2014-12-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and K{sub S} bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and K{sub S} bands, and determine T {sub eff}= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, K{sub S} , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T {sub p} = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072{sub −0.0064}{sup +0.0700} when combined with radial velocity data and is more consistent with a circular orbit.

  11. Characterization of the Atmosphere of the Hot Jupiter HAT-P-32Ab and the M-dwarf Companion HAT-P-32B

    NASA Astrophysics Data System (ADS)

    Zhao, Ming; O'Rourke, Joseph G.; Wright, Jason T.; Knutson, Heather A.; Burrows, Adam; Fortney, Johnathan; Ngo, Henry; Fulton, Benjamin J.; Baranec, Christoph; Riddle, Reed; Law, Nicholas M.; Muirhead, Philip S.; Hinkley, Sasha; Showman, Adam P.; Curtis, Jason; Burruss, Rick

    2014-12-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and KS bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and KS bands, and determine T eff= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, KS , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T p = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072+0.0700-0.0064 when combined with radial velocity data and is more consistent with a circular orbit.

  12. Corner sharing tetrahedral network in Co(3)(HAT)[N(CN)(2)](6)(OH(2))(2) (HAT = 1,4,5,8,9,12-hexaazatriphenylene).

    PubMed

    Marshall, Shireen R; Rheingold, Arnold L; Dawe, Louise N; Shum, William W; Kitamura, Chitoshi; Miller, Joel S

    2002-07-15

    We report a trinuclear Co(II) complex containing bridging dicyanamides and a tris-chelated HAT, which possesses approximately 37% void space. The magnetic exchange pathways appear in the structure as a corner sharing tetrahedral network. The compound crystallizes in the monoclinic space group P2(1)/c [a = 13.655(3) A, b = 15.189(3) A, c = 22.367(4) A, beta = 114.100(2) degrees, V = 4234.5(14) A(3), Z = 4, R(F(o)) = 0.0823]. The magnetic data were fit to an S = 3/2 model for systems dominated by zero-field splitting effects with g = 2.01 and D = 38.9 cm(-1). PMID:12099860

  13. Orbital Phase Variations of the Eccentric Giant Planet HAT-P-2b

    NASA Astrophysics Data System (ADS)

    Lewis, Nikole K.; Knutson, Heather A.; Showman, Adam P.; Cowan, Nicolas B.; Laughlin, Gregory; Burrows, Adam; Deming, Drake; Crepp, Justin R.; Mighell, Kenneth J.; Agol, Eric; Bakos, Gáspár Á.; Charbonneau, David; Désert, Jean-Michel; Fischer, Debra A.; Fortney, Jonathan J.; Hartman, Joel D.; Hinkley, Sasha; Howard, Andrew W.; Johnson, John Asher; Kao, Melodie; Langton, Jonathan; Marcy, Geoffrey W.

    2013-04-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 μm bands of the Spitzer Space Telescope. The 3.6 and 4.5 μm data sets span an entire orbital period of HAT-P-2b (P = 5.6334729 d), making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 μm that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39 ± 0.28, 5.84 ± 0.39, and 4.68 ± 0.37 hr after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138% ± 0.0089%, 0.1162% ± 0.0080%, and 0.1888% ± 0.0072% in the 3.6, 4.5, and 8.0 μm bands, respectively. Our measured secondary eclipse depths of 0.0996% ± 0.0072%, 0.1031% ± 0.0061%, 0.071%^{+0.029%}_{-0.013%}, and 0.1392% ± 0.0095% in the 3.6, 4.5, 5.8, and 8.0 μm bands, respectively, indicate that the planet cools significantly from its peak temperature before we measure the dayside flux during secondary eclipse. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, which suggests the possible presence of a transient day side inversion in HAT-P-2b's atmosphere near periapse. We also derive improved estimates for the system parameters, including its mass, radius, and orbital ephemeris. Our simultaneous fit to the transit, secondary eclipse, and radial velocity data allows us to determine the eccentricity (e = 0.50910 ± 0.00048) and argument of periapse (ω = 188.°09 ± 0.°39) of HAT-P-2b's orbit with a greater precision than has been achieved for any other eccentric extrasolar planet. We also find evidence for a long-term linear trend in the radial velocity data. This trend suggests the presence

  14. ORBITAL PHASE VARIATIONS OF THE ECCENTRIC GIANT PLANET HAT-P-2b

    SciTech Connect

    Lewis, Nikole K.; Showman, Adam P.; Knutson, Heather A.; Desert, Jean-Michel; Kao, Melodie; Cowan, Nicolas B.; Laughlin, Gregory; Fortney, Jonathan J.; Burrows, Adam; Bakos, Gaspar A.; Hartman, Joel D.; Deming, Drake; Crepp, Justin R.; Mighell, Kenneth J.; Agol, Eric; Charbonneau, David; Fischer, Debra A.; Hinkley, Sasha; Johnson, John Asher; Howard, Andrew W.; and others

    2013-04-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 {mu}m bands of the Spitzer Space Telescope. The 3.6 and 4.5 {mu}m data sets span an entire orbital period of HAT-P-2b (P = 5.6334729 d), making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 {mu}m that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39 {+-} 0.28, 5.84 {+-} 0.39, and 4.68 {+-} 0.37 hr after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138% {+-} 0.0089%, 0.1162% {+-} 0.0080%, and 0.1888% {+-} 0.0072% in the 3.6, 4.5, and 8.0 {mu}m bands, respectively. Our measured secondary eclipse depths of 0.0996% {+-} 0.0072%, 0.1031% {+-} 0.0061%, 0.071%{sub -0.013%}{sup +0.029,} and 0.1392% {+-} 0.0095% in the 3.6, 4.5, 5.8, and 8.0 {mu}m bands, respectively, indicate that the planet cools significantly from its peak temperature before we measure the dayside flux during secondary eclipse. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, which suggests the possible presence of a transient day side inversion in HAT-P-2b's atmosphere near periapse. We also derive improved estimates for the system parameters, including its mass, radius, and orbital ephemeris. Our simultaneous fit to the transit, secondary eclipse, and radial velocity data allows us to determine the eccentricity (e = 0.50910 {+-} 0.00048) and argument of periapse ({omega} = 188. Degree-Sign 09 {+-} 0. Degree-Sign 39) of HAT-P-2b's orbit with a greater precision than has been achieved for any other eccentric extrasolar planet. We also find evidence for a long-term linear

  15. HATS-18b: An Extreme Short-period Massive Transiting Planet Spinning Up Its Star

    NASA Astrophysics Data System (ADS)

    Penev, K.; Hartman, J. D.; Bakos, G. Á.; Ciceri, S.; Brahm, R.; Bayliss, D.; Bento, J.; Jordán, A.; Csubry, Z.; Bhatti, W.; de Val-Borro, M.; Espinoza, N.; Zhou, G.; Mancini, L.; Rabus, M.; Suc, V.; Henning, T.; Schmidt, B.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2016-11-01

    We report the discovery by the HATSouth network of HATS-18b: a 1.980+/- 0.077 {M}{{J}}, {1.337}-0.049+0.102 {R}{{J}} planet in a 0.8378 day orbit, around a solar analog star (mass 1.037+/- 0.047 {M}ȯ and radius {1.020}-0.031+0.057 {R}ȯ ) with V=14.067+/- 0.040 mag. The high planet mass, combined with its short orbital period, implies strong tidal coupling between the planetary orbit and the star. In fact, given its inferred age, HATS-18 shows evidence of significant tidal spin up, which together with WASP-19 (a very similar system) allows us to constrain the tidal quality factor for Sun-like stars to be in the range of 6.5≲ {{log}}10({Q}* /{k}2)≲ 7 even after allowing for extremely pessimistic model uncertainties. In addition, the HATS-18 system is among the best systems (and often the best system) for testing a multitude of star–planet interactions, be they gravitational, magnetic, or radiative, as well as planet formation and migration theories. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope.

  16. HATS-2b: A transiting extrasolar planet orbiting a K-type star showing starspot activity

    NASA Astrophysics Data System (ADS)

    Mohler-Fischer, M.; Mancini, L.; Hartman, J. D.; Bakos, G. Á.; Penev, K.; Bayliss, D.; Jordán, A.; Csubry, Z.; Zhou, G.; Rabus, M.; Nikolov, N.; Brahm, R.; Espinoza, N.; Buchhave, L. A.; Béky, B.; Suc, V.; Csák, B.; Henning, T.; Wright, D. J.; Tinney, C. G.; Addison, B. C.; Schmidt, B.; Noyes, R. W.; Papp, I.; Lázár, J.; Sári, P.; Conroy, P.

    2013-10-01

    We report the discovery of HATS-2b, the second transiting extrasolar planet detected by the HATSouth survey. HATS-2b is moving on a circular orbit around a V = 13.6 mag, K-type dwarf star (GSC 6665-00236), at a separation of 0.0230 ± 0.0003 AU and with a period of 1.3541 days. The planetary parameters have been robustly determined using a simultaneous fit of the HATSouth, MPG/ESO 2.2 m/GROND, Faulkes Telescope South/Spectral transit photometry, and MPG/ESO 2.2 m/FEROS, Euler 1.2 m/CORALIE, AAT 3.9 m/CYCLOPS radial-velocity measurements. HATS-2b has a mass of 1.37 ± 0.16 MJ, a radius of 1.14 ± 0.03 RJ, and an equilibrium temperature of 1567 ± 30 K. The host star has a mass of 0.88 ± 0.04 M⊙ and a radius of 0.89 ± 0.02 R⊙, and it shows starspot activity. We characterized the stellar activity by analyzing two photometric follow-up transit light curves taken with the GROND instrument, both obtained simultaneously in four optical bands (covering the wavelength range of 3860-9520 Å). The two light curves contain anomalies compatible with starspots on the photosphere of the host star along the same transit chord. Tables of the individual photometric measurements are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/558/A55

  17. On Application of the 3-Cornered Hat Technique to Radio Source Position Catalogs

    NASA Astrophysics Data System (ADS)

    Malkin, Z.

    2013-08-01

    So called ``3-cornered hat'' method (3CH) was originally developed for estimation of the stability of frequency standards (Gray1974). It was then applied for investigation of the noise level of various data, in particular, astronomical and geodetic time series and radio source position catalogs. However, despite this method is widely used, its application is not straightforward because it requires a reliable estimate of the correlations between series under investigation. Neglecting correlations often produces unacceptable results, like negative variances. In this work, we investigate a new possibility to estimate correlations between radio source position catalogs (RSC) obtained from VLBI observations.

  18. Multi-jet Cross Sections at NLO with BlackHat and Sherpa

    SciTech Connect

    Berger, C.F.; Bern, Z.; Dixon, L.J.; Cordero, F.Febres; Forde, D.; Gleisberg, T.; Ita, H.; Kosower, D.A.; Maitre, D.

    2009-05-20

    In this talk, we report on a recent next-to-leading order QCD calculation of the production of a W boson in association with three jets at hadron colliders. The computation is performed by combining two programs, BlackHat for the computation of the virtual one-loop matrix elements and Sherpa for the real emission part. The addition of NLO corrections greatly reduces the factorization and renormalization scale dependence of the theory prediction for this process. This result demonstrates the applicability of unitarity-based methods for hadron collider physics.

  19. An active hAT transposable element causing bud mutation of carnation by insertion into the flavonoid 3'-hydroxylase gene.

    PubMed

    Momose, Masaki; Nakayama, Masayoshi; Itoh, Yoshio; Umemoto, Naoyuki; Toguri, Toshihiro; Ozeki, Yoshihiro

    2013-04-01

    The molecular mechanisms underlying spontaneous bud mutations, which provide an important breeding tool in carnation, are poorly understood. Here we describe a new active hAT type transposable element, designated Tdic101, the movement of which caused a bud mutation in carnation that led to a change of flower color from purple to deep pink. The color change was attributed to Tdic101 insertion into the second intron of F3'H, the gene for flavonoid 3'-hydroxylase responsible for purple pigment production. Regions on the deep pink flowers of the mutant can revert to purple, a visible phenotype of, as we show, excision of the transposable element. Sequence analysis revealed that Tdic101 has the characteristics of an autonomous element encoding a transposase. A related, but non-autonomous element dTdic102 was found to move in the genome of the bud mutant as well. Its mobilization might be the result of transposase activities provided by other elements such as Tdic101. In carnation, therefore, the movement of transposable elements plays an important role in the emergence of a bud mutation.

  20. Two hAT transposon genes were transferred from Brassicaceae to broomrapes and are actively expressed in some recipients

    PubMed Central

    Sun, Ting; Renner, Susanne S.; Xu, Yuxing; Qin, Yan; Wu, Jianqiang; Sun, Guiling

    2016-01-01

    A growing body of evidence is pointing to an important role of horizontal gene transfer (HGT) in the evolution of higher plants. However, reports of HGTs of transposable elements (TEs) in plants are still scarce, and only one case is known of a class II transposon horizontally transferred between grasses. To investigate possible TE transfers in dicots, we performed transcriptome screening in the obligate root parasite Phelipanche aegyptiaca (Orobanchaceae), data-mining in the draft genome assemblies of four other Orobanchaceae, gene cloning, gene annotation in species with genomic information, and a molecular phylogenetic analysis. We discovered that the broomrape genera Phelipanche and Orobanche acquired two related nuclear genes (christened BO transposase genes), a new group of the hAT superfamily of class II transposons, from Asian Sisymbrieae or a closely related tribe of Brassicaceae, by HGT. The collinearity of the flanking genes, lack of a classic border structure, and low expression levels suggest that BO transposase genes cannot transpose in Brassicaceae, whereas they are highly expressed in P. aegyptiaca. PMID:27452947

  1. Design and evaluation of a foam-filled hat-stiffened panel concept for aircraft primary structural applications

    NASA Technical Reports Server (NTRS)

    Ambur, Damodar R.

    1993-01-01

    Geodesically stiffened structures are very efficient in carrying combined bending, torsion, and pressure loading that is typical of primary aircraft structures. They are also very damage tolerant since there are multiple load paths available to redistribute loads compared to prismatically stiffened structures. Geodesically stiffened structures utilize continuous filament composite materials which make them amenable to automated manufacturing processes to reduce cost. The current practice for geodesically stiffened structures is to use a solid blade construction for the stiffener. This stiffener configuration is not an efficient concept and there is a need to identify other stiffener configurations that are more efficient but utilize the same manufacturing process as the solid blade. This paper describes a foam-filled stiffener cross section that is more efficient than a solid-blade stiffener in the load range corresponding to primary aircraft structures. A prismatic hat-stiffener panel design is then selected for structural evaluation in uni-axial compression with and without impact damage. Experimental results for both single stiffener specimens and multi-stiffener panel specimens are presented. Finite element analysis results are presented that predict the buckling and postbuckling response of the test specimens. Analytical results for both the element and panel specimens are compared with experimental results.

  2. A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster

    PubMed Central

    Boltengagen, Mark; Huang, Anming; Boltengagen, Anastasiya; Trixl, Lukas; Lindner, Herbert; Kremser, Leopold; Offterdinger, Martin; Lusser, Alexandra

    2016-01-01

    The incorporation of CENP-A into centromeric chromatin is an essential prerequisite for kinetochore formation. Yet, the molecular mechanisms governing this process are surprisingly divergent in different organisms. While CENP-A loading mechanisms have been studied in some detail in mammals, there are still large gaps to our understanding of CENP-A/Cid loading pathways in Drosophila. Here, we report on the characterization and delineation of at least three different CENP-A preloading complexes in Drosophila. Two complexes contain the CENP-A chaperones CAL1, FACT and/or Caf1/Rbap48. Notably, we identified a novel complex consisting of the histone acetyltransferase Hat1, Caf1 and CENP-A/H4. We show that Hat1 is required for proper CENP-A loading into chromatin, since knock-down in S2 cells leads to reduced incorporation of newly synthesized CENP-A. In addition, we demonstrate that CENP-A/Cid interacts with the HAT1 complex via an N-terminal region, which is acetylated in cytoplasmic but not in nuclear CENP-A. Since Hat1 is not responsible for acetylation of CENP-A/Cid, these results suggest a histone acetyltransferase activity-independent escort function for Hat1. Thus, our results point toward intriguing analogies between the complex processing pathways of newly synthesized CENP-A and canonical histones. PMID:26586808

  3. Structural Performance of a Compressively Loaded Foam-Core Hat-Stiffened Textile Composite Panel

    NASA Technical Reports Server (NTRS)

    Ambur, Damodar R.; Dexter, Benson H.

    1996-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as a stiffener core material has been designed and developed for aircraft primary structural applications. This stiffener concept is fabricated from textile composite material forms with a resin transfer molding process. This foam-filled hat-stiffener concept is structurally more efficient than most other prismatically stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The panel design is based on woven/stitched and braided graphite-fiber textile preforms, an epoxy resin system, and Rohacell foam core. The structural response of this panel design was evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimen tests suggest that this structural concept responds to loading as anticipated and has excellent damage tolerance characteristics compared to a similar panel design made from preimpregnated graphite-epoxy tape material.

  4. Analytical and experimental study of structurally efficient composite hat-stiffened panels loaded in axial compression

    NASA Technical Reports Server (NTRS)

    Williams, J. G.; Mikulas, M. M., Jr.

    1975-01-01

    Structural efficiency studies were made to determine the weight-saving potential of graphite/epoxy composite structures for compression panel applications. Minimum-weight hat-stiffened and open-corrugation configurations were synthesized using a nonlinear mathematical programing technique. Selected configurations were built and tested to study local and Euler buckling characteristics. Test results for 23 panels critical in local buckling and six panels critical in Euler buckling are compared with analytical results obtained using the BUCLASP-2 branched plate buckling program. A weight efficiency comparison is made between composite and aluminum compression panels using metal test data generated by the NACA. Theoretical studies indicate that potential weight savings of up to 50% are possible for composite hat-stiffened panels when compared with similar aluminum designs. Weight savings of 32% to 42% were experimentally achieved. Experience to date suggests that most of the theoretical weight-saving potential is available if design deficiencies are eliminated and strict fabrication control is exercised.

  5. The G-HAT Search for Advanced Extraterrestrial Civilizations: The Reddest Extended WISE Sources

    NASA Astrophysics Data System (ADS)

    Maldonado, Jessica; Povich, Matthew S.; Wright, Jason; Griffith, Roger; Sigurdsson, Steinn; Mullan, Brendan L.

    2015-01-01

    Freeman Dyson (1960) theorized how to identify possible signatures of advanced extra-terrestrial civilizations by their waste heat, an inevitable byproduct of a civilization using a significant fraction of the luminosity from their host star. If a civilizations could tap the starlight throughout their host galaxy their waste heat would be easily detectable by recent infrared surveys. The Glimpsing Heat from Alien Technologies (G-HAT) pilot project aims to place limits on the existence of extraterrestrial civilizations at pan-galactic scales. We present results from the G-HAT cleaned catalog of 563 extremely red, extended high Galactic latitude (|b| ≥ 10) sources from the WISE All-Sky Catalog. Our catalog includes sources new to the scientific literature along with well-studied objects (e.g. starburst galaxies, AGN, and planetary nebulae) that exemplify extreme WISE colors. Objects of particular interest include a supergiant Be star (48 Librae) surrounded by a resolved, mid-infrared nebula, possibly indicating dust in the stellar wind ejecta, and a curious cluster of seven extremely red WISE sources (associated with IRAS 04287+6444) that have no optical counterparts.

  6. HATS-3b: AN INFLATED HOT JUPITER TRANSITING AN F-TYPE STAR

    SciTech Connect

    Bayliss, D.; Zhou, G.; Schmidt, B.; Penev, K.; Bakos, G. Á.; Hartman, J. D.; Csubry, Z.; Jordán, A.; Suc, V.; Rabus, M.; Brahm, R.; Espinoza, N.; Mancini, L.; Mohler-Fischer, M.; Henning, T.; Nikolov, N.; Csák, B.; Béky, B.; Noyes, R. W.; Buchhave, L.; and others

    2013-11-01

    We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V = 12.4 F dwarf star. HATS-3b has a period of P = 3.5479 days, mass of M{sub p} = 1.07 M {sub J}, and radius of R{sub p} = 1.38 R {sub J}. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsin i = 9.0 km s{sup –1}), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low-/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces log g and T {sub eff} parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km s{sup –1}.

  7. THE OBLIQUE ORBIT OF THE SUPER-NEPTUNE HAT-P-11b

    SciTech Connect

    Winn, Joshua N.; Albrecht, Simon; Johnson, John Asher; Howard, Andrew W.; Marcy, Geoffrey W.; Isaacson, Howard; Shporer, Avi; Bakos, Gaspar A.; Hartman, Joel D.

    2010-11-10

    We find the orbit of the Neptune-sized exoplanet HAT-P-11b to be highly inclined relative to the equatorial plane of its host star. This conclusion is based on spectroscopic observations of two transits, which allowed the Rossiter-McLaughlin effect to be detected with an amplitude of 1.5 m s{sup -1}. The sky-projected obliquity is 103{sup +26} {sub -10} deg. This is the smallest exoplanet for which spin-orbit alignment has been measured. The result favors a migration scenario involving few-body interactions followed by tidal dissipation. This finding also conforms with the pattern that the systems with the weakest tidal interactions have the widest spread in obliquities. We predict that the high obliquity of HAT-P-11 will be manifest in transit light curves from the Kepler spacecraft: starspot-crossing anomalies will recur at most once per stellar rotation period, rather than once per orbital period as they would for a well-aligned system.

  8. FURTHER CONSTRAINTS ON THE OPTICAL TRANSMISSION SPECTRUM OF HAT-P-1b

    SciTech Connect

    Montalto, M.; Santos, N. C.; Martins, J. H. C.; Figueira, P.; Alonso, R.; Iro, N.; Desidera, S.

    2015-09-20

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo. Our measurements imply an average planet to star radius ratio equal to R{sub p}/R{sub *} = (0.1159 ± 0.0005). This result is consistent with the value obtained from recent near-infrared measurements of this object, but differs from previously reported optical measurements, being lower by around 4.4 exoplanet scale heights. Analyzing the data over five different spectral bins of ∼600 Å wide, we observed a single peaked spectrum (3.7 σ level) with a blue cutoff corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in-between 6180 and 7400 Å. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower than the one implied by solar abundance clear atmospheric models. We interpret the result as evidence that HAT-P-1b has a partially clear atmosphere at optical wavelengths with a more modest contribution from an optical absorber than previously reported.

  9. Transmission Spectroscopy of HAT-P-32Ab with GTC/OSIRIS

    NASA Astrophysics Data System (ADS)

    Nortmann, Lisa; Pallé, Enric; Murgas, Felipe; Dreizler, Stefan; Iro, Nicolas; Cabrera-Lavers, Antonio

    2015-12-01

    I will present one of the latest results of our GTC exoplanet transit spectroscopy survey. Over the last years our group has obtained ground-based optical (538 nm - 918 nm) spectrophotometric transit observations for several hot Jupiters including HAT-P-32Ab using the OSIRIS (Optical System for Imaging and low Resolution Integrated Spectroscopy) instrument at the Spanish 10-meter telescope GTC.I will discuss the source, nature and proper correction of instrument specific systematic noise we found to affect our data. After its correction, we were able to yield high quality results with a precision between 482 and 1703 ppm depending on the wavelength channel. We measure a flat optical transmission spectrum for HAT-P-32Ab, consistent with the results of Gibson et al. (2013, MNRAS, 436, 2974) obtained with GMOS at Gemini-North. This independent reproduction of consistent results re-establishes faith in the reliability of ground-based transmission spectroscopy and emphasizes the high potential of OSIRIS at the GTC as a tool to complement current and future space-based observations.

  10. The nature of the Napoleon's Hat nebula of SN 1987A

    NASA Astrophysics Data System (ADS)

    Wang, L.; Dyson, J. E.; Kahn, F. D.

    1993-03-01

    The interstellar and circumstellar environment of SN 1987A is modeled. The geometries of Napoleon's Hat nebula and the dark bay suggest that there is relative motion between the SN progenitor and the surrounding ISM. Most of the dark bay can be identified with the bubble produced by the fast blue supergiant (BSG) wind before the red supergiant (RSG) stage. The relative motion between the star and the ISM is the primary reason for the star being at the edge of this bubble. After the first BSG stage, the star evolves to the RSG stage; the wind velocity is now typically 10 km/s and the mass loss rate is around 10 exp -5 solar mass/yr. The star eventually breaks through the bubble produced in the early BSG stage and starts to interact directly with the ISM outside, thus producing Napoleon's Hat. The success of this model is convincing proof of the BSG-RSG-BSG evolutionary model for the SN 1987A progenitors, and shows that is has moved from the site where it was formed.

  11. Free radical scavenger properties of α-mangostin: thermodynamics and kinetics of HAT and RAF mechanisms.

    PubMed

    Martínez, Ana; Galano, Annia; Vargas, Rubicelia

    2011-11-01

    Mangosteen is a tropical fruit that presents beneficial effects on human health since it is rich in anthocyanins and xanthones, which are considered bioactive compounds that have been described as good free radical scavengers. One of its most active compounds is α-mangostin. In this report, a theoretical study on the free radical scavenger capacity of α-mangostin and its monoanion is analyzed using the density functional theory approximation. Two well-known reaction mechanisms are investigated: the hydrogen atom transfer (HAT) and the radical adduct formation (RAF). Two other mechanisms are also considered: sequential electron proton Transfer (SEPT) and proton coupled electron transfer (PCET). According to thermodynamics and kinetics, α-mangostin and its deprotonated form are good free radical scavenger through the HAT mechanism, with the anionic (deprotonated) form being more reactive than the neutral one. Their capacity to scavenge OOH free radical is similar to that of carotenes, higher than that of allicin, much higher than that of melatonin and N-acetylcysteine amide, and about 15 times lower than that of 2-propenesulfenic acid.

  12. Implications of the Secondary Eclipse of Exoplanet HAT-P-11b

    NASA Technical Reports Server (NTRS)

    Barry, Richard K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We observed exoplanet HAT-P-11b and have successfully detected its secondary eclipse. We conducted observations using the Spitzer Space Telescope in the post-cryo mission at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b is one of only two known exo-Neptunes and has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. We discuss implications of these observations.

  13. Design and Optimization of a Compact Wideband Hat-Fed Reflector Antenna for Satellite Communications

    NASA Astrophysics Data System (ADS)

    Geterud, Erik G.; Yang, Jian; Ostling, Tomas; Bergmark, Pontus

    2013-01-01

    We present a new design of the hat-fed reflector antenna for satellite communications, where a low reflection coefficient, high gain, low sidelobes and low cross-polar level are required over a wide frequency band. The hat feed has been optimized by using the Genetic Algorithm through a commercial FDTD solver, QuickWave-V2D, together with an own developed optimization code. The Gaussian vertex plate has been applied at the center of the reflector in order to improve the reflection coefficient and reduce the far-out sidelobes. A parabolic reflector with a ring-shaped focus has been designed for obtaining nearly 100% phase efficiency. The antenna's reflection coefficient is below -17 dB and the radiation patterns satisfy the M-x standard co- and cross-polar sidelobe envelopes for satellite ground stations over a bandwidth of 30%. A low-cost monolayer radome has been designed for the antenna with satisfactory performance. The simulations have been verified by measurements; both of them are presented in the paper.

  14. Is lightning a possible source of the radio emission on HAT-P-11b?

    NASA Astrophysics Data System (ADS)

    Hodosán, G.; Rimmer, P. B.; Helling, Ch.

    2016-09-01

    Lightning induced radio emission has been observed on Solar system planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. Here, we assume that this signal is real, and study if this radio emission could be caused by lightning with similar energetic properties like in the Solar system. We find that a lightning storm with 3.8 × 106 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical emission of such thunderstorm would be comparable to that of the host star. We show that HCN produced by lightning chemistry is observable 2-3 yr after the storm, which produces signatures in the L (3.0-4.0 μm) and N (7.5-14.5 μm) infrared bands. We conclude that it is unlikely that the observed radio signal was produced by lightning, however, future, combined radio and infrared observations may lead to lightning detection on planets outside the Solar system.

  15. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Appendix D, Addenda D1--D7

    SciTech Connect

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation foe the US Department of Energy (DOE), Grand Junction Project Office, in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. the objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on-pile sampling was required to determine the depth of the 15-pCi/g Ra-226 interface in an area where wind and water erosion has taken place.

  16. Phosphorylation of Tip60 Tyrosine 327 by Abl Kinase Inhibits HAT Activity through Association with FE65

    PubMed Central

    Shin, Sung Hwa; Kang, Sang Sun

    2013-01-01

    The transfer of acetyl groups from acetyl coenzyme A to the ε amino group of internal lysine residues is catalyzed by Tip60, which is in the MYST family of nuclear histone acetyltransferases (HATs). The tyrosine phosphorylation of Tip60 seems to be a unique modification. We present evidence that Tip60 is modified on tyrosine 327 by Abl kinase. We show that this causes functional changes in HAT activity and the subcellular localization of TIP60, which forms a complex with Abl kinase. The Tip60 mutation Y327F abolished tyrosine phosphorylation, reduced the inhibition of Tip60 HAT activity, and caused G0-G1 arrest and association with FE65. Thus, our findings for the first time suggested a novel regulation mechanism of Tip60. Regulation was through phosphorylation of tyrosine 327 by Abl tyrosine kinase and depended on environmental conditions, suggesting that the tyrosine residue of Tip60 is important for the activation process. PMID:24044023

  17. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    NASA Astrophysics Data System (ADS)

    Bakos, G. Á.; Penev, K.; Bayliss, D.; Hartman, J. D.; Zhou, G.; Brahm, R.; Mancini, L.; de Val-Borro, M.; Bhatti, W.; Jordán, A.; Rabus, M.; Espinoza, N.; Csubry, Z.; Howard, A. W.; Fulton, B. J.; Buchhave, L. A.; Ciceri, S.; Henning, T.; Schmidt, B.; Isaacson, H.; Noyes, R. W.; Marcy, G. W.; Suc, V.; Howe, A. R.; Burrows, A. S.; Lázár, J.; Papp, I.; Sári, P.

    2015-11-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120 ± 0.012 {M}{{J}}, a radius of {0.563}-0.034+0.046 {R}{{J}}, and an orbital period of 3.1853 days. The host star is a moderately bright (V=13.340\\+/- 0.010 mag, {K}S=10.976\\+/- 0.026 mag) K dwarf star with a mass of 0.849 ± 0.027 {M}ȯ , a radius of {0.815}-0.035+0.049 {R}ȯ , and a metallicity of [{Fe}/{{H}}] =+0.250\\+/- 0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen–helium fraction of 18 ± 4% (rock-iron core and H2–He envelope), or 9 ± 4% (ice core and H2–He envelope), i.e., it has a composition broadly similar to that of Uranus and Neptune, and very different from that of Saturn, which has 75% of its mass in H2–He. Based on a sample of transiting exoplanets with accurately (<20%) determined parameters, we establish approximate power-law relations for the envelopes of the mass–density distribution of exoplanets. HATS-7b, which, together with the recently discovered HATS-8b, is one of the first two transiting super-Neptunes discovered in the Southern sky, is a prime target for additional follow-up observations with Southern hemisphere facilities to characterize the atmospheres of Super-Neptunes (which we define as objects with mass greater than that of Neptune, and smaller than halfway between that of Neptune and Saturn, i.e., 0.054 {M}{{J}}\\lt {M}{{p}}\\lt 0.18 {M}{{J}}). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the

  18. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    NASA Astrophysics Data System (ADS)

    Bakos, G. Á.; Penev, K.; Bayliss, D.; Hartman, J. D.; Zhou, G.; Brahm, R.; Mancini, L.; de Val-Borro, M.; Bhatti, W.; Jordán, A.; Rabus, M.; Espinoza, N.; Csubry, Z.; Howard, A. W.; Fulton, B. J.; Buchhave, L. A.; Ciceri, S.; Henning, T.; Schmidt, B.; Isaacson, H.; Noyes, R. W.; Marcy, G. W.; Suc, V.; Howe, A. R.; Burrows, A. S.; Lázár, J.; Papp, I.; Sári, P.

    2015-11-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120 ± 0.012 {M}{{J}}, a radius of {0.563}-0.034+0.046 {R}{{J}}, and an orbital period of 3.1853 days. The host star is a moderately bright (V=13.340\\+/- 0.010 mag, {K}S=10.976\\+/- 0.026 mag) K dwarf star with a mass of 0.849 ± 0.027 {M}⊙ , a radius of {0.815}-0.035+0.049 {R}⊙ , and a metallicity of [{Fe}/{{H}}] =+0.250\\+/- 0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen-helium fraction of 18 ± 4% (rock-iron core and H2-He envelope), or 9 ± 4% (ice core and H2-He envelope), i.e., it has a composition broadly similar to that of Uranus and Neptune, and very different from that of Saturn, which has 75% of its mass in H2-He. Based on a sample of transiting exoplanets with accurately (<20%) determined parameters, we establish approximate power-law relations for the envelopes of the mass-density distribution of exoplanets. HATS-7b, which, together with the recently discovered HATS-8b, is one of the first two transiting super-Neptunes discovered in the Southern sky, is a prime target for additional follow-up observations with Southern hemisphere facilities to characterize the atmospheres of Super-Neptunes (which we define as objects with mass greater than that of Neptune, and smaller than halfway between that of Neptune and Saturn, i.e., 0.054 {M}{{J}}\\lt {M}{{p}}\\lt 0.18 {M}{{J}}). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia

  19. HAT-P-17b,c: A TRANSITING, ECCENTRIC, HOT SATURN AND A LONG-PERIOD, COLD JUPITER

    SciTech Connect

    Howard, A. W.; Marcy, G. W.; Bakos, G. A.; Hartman, J.; Torres, G.; Latham, D. W.; Noyes, R. W.; Esquerdo, G. A.; Beky, B.; Sasselov, D. D.; Stefanik, R. P.; Perumpilly, G.; Shporer, A.; Mazeh, T.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Butler, R. P.; Lazar, J.; Papp, I. E-mail: gbakos@cfa.harvard.edu; and others

    2012-04-20

    We report the discovery of HAT-P-17b,c, a multi-planet system with an inner transiting planet in a short-period, eccentric orbit and an outer planet in a 4.4 yr, nearly circular orbit. The inner planet, HAT-P-17b, transits the bright V = 10.54 early K dwarf star GSC 2717-00417, with an orbital period P = 10.338523 {+-} 0.000009 days, orbital eccentricity e = 0.342 {+-} 0.006, transit epoch T{sub c} = 2454801.16943 {+-} 0.00020 (BJD: barycentric Julian dates throughout the paper are calculated from Coordinated Universal Time (UTC)), and transit duration 0.1690 {+-} 0.0009 days. HAT-P-17b has a mass of 0.534 {+-} 0.018 M{sub J} and radius of 1.010 {+-} 0.029 R{sub J} yielding a mean density of 0.64 {+-} 0.05 g cm{sup -3}. This planet has a relatively low equilibrium temperature in the range 780-927 K, making it an attractive target for follow-up spectroscopic studies. The outer planet, HAT-P-17c, has a significantly longer orbital period P{sub 2} = 1610 {+-} 20 days and a minimum mass m{sub 2}sin i{sub 2} = 1.31{sup +0.18}{sub -0.15} M{sub J}. The orbital inclination of HAT-P-17c is unknown as transits have not been observed and may not be present. The host star has a mass of 0.86 {+-} 0.04 M{sub Sun }, radius of 0.84 {+-} 0.02 R{sub Sun }, effective temperature 5246 {+-} 80 K, and metallicity [Fe/H] = 0.00 {+-} 0.08. HAT-P-17 is the second multi-planet system detected from ground-based transit surveys.

  20. Final audit report of remedial action construction at the UMTRA Project Mexican Hat, Utah -- Monument Valley, Arizona, sites

    SciTech Connect

    1995-10-01

    The final audit report for remedial action at the Mexican Hat, Utah, Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites consists of a summary of the radiological surveillances/audits, quality assurance (QA) in-process surveillances, and QA remedial action close-out inspections performed by the US Department of Energy (DOE) and the Technical Assistance Contractor (TAC); on-site construction reviews (OSCR) performed by the US Nuclear Regulatory Commission (NRC); and a surveillance performed by the Navajo Nation. This report refers to remedial action activities performed at the Mexican Hat, Utah--Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites.

  1. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex.

    PubMed

    Foy, Rebecca L; Song, Ihn Young; Chitalia, Vipul C; Cohen, Herbert T; Saksouk, Nehme; Cayrou, Christelle; Vaziri, Cyrus; Côté, Jacques; Panchenko, Maria V

    2008-10-24

    Regulation of global chromatin acetylation is important for chromatin remodeling. A small family of Jade proteins includes Jade-1L, Jade-2, and Jade-3, each bearing two mid-molecule tandem plant homology domain (PHD) zinc fingers. We previously demonstrated that the short isoform of Jade-1L protein, Jade-1, is associated with endogenous histone acetyltransferase (HAT) activity. It has been found that Jade-1L/2/3 proteins co-purify with a novel HAT complex, consisting of HBO1, ING4/5, and Eaf6. We investigated a role for Jade-1/1L in the HBO1 complex. When overexpressed individually, neither Jade-1/1L nor HBO1 affected histone acetylation. However, co-expression of Jade-1/1L and HBO1 increased acetylation of the bulk of endogenous histone H4 in epithelial cells in a synergistic manner, suggesting that Jade1/1L positively regulates HBO1 HAT activity. Conversely, small interfering RNA-mediated depletion of endogenous Jade resulted in reduced levels of H4 acetylation. Moreover, HBO1-mediated H4 acetylation activity was enhanced severalfold by the presence of Jade-1/1L in vitro. The removal of PHD fingers affected neither binding nor mutual Jade-1-HBO1 stabilization but completely abrogated the synergistic Jade-1/1L- and HBO1-mediated histone H4 acetylation in live cells and in vitro with reconstituted oligonucleosome substrates. Therefore, PHDs are necessary for Jade-1/1L-induced acetylation of nucleosomal histones by HBO1. In contrast to Jade-1/1L, the PHD zinc finger protein ING4/5 failed to synergize with HBO1 to promote histone acetylation. The physical interaction of ING4/5 with HBO1 occurred in the presence of Jade-1L or Jade-3 but not with the Jade-1 short isoform. In summary, this study demonstrates that Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation.

  2. Monitoring glaciers and indications of subglacial volcanic activity using small-scale Top-Hat reflectors - An IsViews experiment on Myrdalsjökull, Iceland

    NASA Astrophysics Data System (ADS)

    Minet, Christian; Duque Biarge, Sergi; Jaenicke, Julia; Münzer, Ulrich; Mayer, Christoph; Franke, Jonas; Guðmundsson, Águst; Parizzi, Alessandro; Fritz, Thomas; Eineder, Michael

    2014-05-01

    Subglacial volcanic eruptions often provide indications of activity some time before the actual catastrophic event. Surface undulations appear on top of the ice cap and meltwater torrents can occur at the glacier margin. Even large scale uplifts of ice caps have been observed. Within the project IsViews a processing chain, based on high spatially and temporally resolved remote sensing imagery, will be developed in order to automatically identify such early indications. The main data used for this analysis are acquired by the TerraSAR-X, TanDEM-X and RapidEye satellites. First investigations concerning the feasibility of the near real-time warning system and the general baseline conditions are carried out on two large plateau glaciers in southern Iceland, namely Mördalsjökull and Vatnajökull. Within the 2013 IsViews field work an experiment was started in order to test a new way of glacier monitoring. Two test sites were established on the Mördalsjökull ice cap (one at the equilibrium line and one below), each consisting of a permanent GPS station and two nearby RADAR reflectors. These RADAR reflectors are specially designed Top-Hat reflectors, which are cheap to manufacture, small (50 cm diameter) and lightweight and therefore easy to handle, transport and deploy. Their special design makes them visible in SAR images independent of orientation, so different acquisition geometries and even different sensors can be used. The drawback of the small, low reflecting Top-Hat can be overcome by using the newly implemented Staring Spotlight Mode of the German SAR Satellite TerraSAR-X, providing an unprecedented resolution of down to 20 cm in the azimuth direction. The reflectors, as point targets, allow absolute positioning within the cm-level in the TerraSAR-X data. Time series of SAR data can be used to derive position and altitude changes of the reflector itself and possibly even melting rates by exploiting the different signal paths. The visibility of the Top-Hat

  3. A near-infrared transmission spectrum for the warm Saturn HAT-P-12b

    SciTech Connect

    Line, Michael R.; Knutson, Heather; Desert, Jean-Michel; Deming, Drake; Wilkins, Ashlee

    2013-12-01

    We present a Hubble Space Telescope Wide Field Camera-3 (WFC3) transmission spectrum for the transiting exoplanet HAT-P-12b. This warm (1000 K) sub-Saturn-mass planet has a smaller mass and a lower temperature than the hot Jupiters that have been studied so far. We find that the planet's measured transmission spectrum lacks the expected water absorption feature for a hydrogen-dominated atmosphere and is instead best described by a model with high-altitude clouds. Using a frequentist hypothesis testing procedure, we can rule out a hydrogen-dominated cloud-free atmosphere to 4.9σ. When combined with other recent WFC3 studies, our observations suggest that clouds may be common in exoplanetary atmospheres.

  4. Viscous Chaplygin gas models as spherical top-hat collapsing fluids

    NASA Astrophysics Data System (ADS)

    Jawad, Abdul; Iqbal, Ayesha

    2016-05-01

    We study the spherical top-hat collapse in Einstein gravity and loop quantum cosmology (LQC) by taking the nonlinear evolution of viscous modified variable Chaplygin gas (CG) and viscous generalized cosmic chaplygin gas (GCCG). We calculate the equation of state (EoS) parameter, square speed of sound, perturbed (EoS) parameter, perturbed square speed of sound, density contrast and divergence of peculiar velocity in perturbed region and discussed their behavior. It is observed that both CG models support the spherical collapse (SC) in Einstein as well as LQC because density contrast remains positive in both cases and the perturbed EoS parameter remains positive at the present epoch as well as near future. It is remarked here that these parameters provide consistent results for both CG models in both gravities.

  5. Self-assembled ordered structures in thin films of HAT5 discotic liquid crystal

    PubMed Central

    Morales, Piero; Lagerwall, Jan; Vacca, Paolo; Laschat, Sabine

    2010-01-01

    Summary Thin films of the discotic liquid crystal hexapentyloxytriphenylene (HAT5), prepared from solution via casting or spin-coating, were investigated by atomic force microscopy and polarizing optical microscopy, revealing large-scale ordered structures substantially different from those typically observed in standard samples of the same material. Thin and very long fibrils of planar-aligned liquid crystal were found, possibly formed as a result of an intermediate lyotropic nematic state arising during the solvent evaporation process. Moreover, in sufficiently thin films the crystallization seems to be suppressed, extending the uniform order of the liquid crystal phase down to room temperature. This should be compared to the bulk situation, where the same material crystallizes into a polymorphic structure at 68 °C. PMID:20625522

  6. Simulated response of top-hat electrostatic analysers - importance of phase-space resolution

    NASA Astrophysics Data System (ADS)

    De Marco, Rossana; Bruno, Roberto; D'Amicis, Raffaella; Federica Marcucci, Maria; Servidio, Sergio; Valentini, Francesco

    2016-04-01

    We use a numerical code able to reproduce the angular/energy response of a typical electrostatic analyzer of top-hat type starting from velocity distribution functions (VDFs) generated by numerical imulations.The simulations are based on the Hybrid Vlasov-Maxwell (HVM) numerical algorithm which integrates the Vlasov equation for the ion distribution function in multi-dimensional geometry in phase space, while the electrons are treated as a fluid. Virtual satellites launched through the simulation box measure the particle VDFs. Such VDFs are interpolated into a spacecraft reference frame and moved from the simulation Cartesian grid to energy-angular coordinates to mimic the response of a real electrostatic sensor in the solar wind and in the magnetosheath for different conditions. We discuss the results of this study with respect to the importance of phase-space resolution for a space plasma experiment meant to investigate kinetic plasma regime.

  7. An Overview of HATS: A Language Independent High Assurance Transformation System

    SciTech Connect

    Winter, V.L.

    1998-10-16

    Transformations that are based on syntax directed rewriting systems can have a significant impact on the construction of high assurance systems. However, in order for a transformational approach to be useful to a particular problem domain, a (general) transformation system must be adapted to the notation of that particular domain. A transformation system that can be easily adapted to various domain notations has the potential of having a wide range of applicability. In this paper we dissus why transforrmtion is attractive horn a high assurance perspective, as well as some issues surrounding automated transformation within specific problem domains. We then give an overview of a language independent High Assurance Transformation System (HATS) that is being developed at Sandia National Laboratories.

  8. Automatic nuclear bud detection using ellipse fitting, moving sticks or top-hat transformation.

    PubMed

    Zhang, C; Sun, C; Vallotton, P; Fenech, M; Pham, T D

    2013-11-01

    Micronucleus assays are extensively used by biologists to assess genotoxicity and to monitor human exposure to genotoxic materials. As recent studies suggested that nuclear buds can be a new source of micronuclei formed in interphase, the quantification of nuclear buds, which are micronucleus like objects that are attached to the nuclei in interphase, in normal and control group is needed. Three automatic nuclear bud detection algorithms fit for different situations are proposed in this paper. One is based on ellipse fitting, one is based on a stick model and the other is based on the top-hat transform. Comparison of the three methods is also given in this paper. Experimental results showed that the proposed algorithms are all effective and efficient for nuclear bud detection. PMID:23961938

  9. Using Edward de Bono's six hats game to aid critical thinking and reflection in palliative care.

    PubMed

    Kenny, Lesley J

    2003-03-01

    This article describes the use of a creative thinking game to stimulate critical thinking and reflection with qualified health professionals undertaking palliative care education. The importance of reflective practice in nursing is well documented and numerous models are available. However, the author as a nurse teacher has found that many of these models are either too simple or too complex to be valuable in practice. The six hats game, devised by Edward de Bono, is a method that stimulates a variety of types of thinking and when used as a means of reflection helps students to become more critical about their practice. Using this game with a palliative care case study the author demonstrates how thinking more creatively about the patients' perceived needs and problems can assist in developing reflective skills. The article concludes with a discussion on some of the challenges of using this method and suggestions for future practical uses. PMID:12682572

  10. Using Edward de Bono's six hats game to aid critical thinking and reflection in palliative care.

    PubMed

    Kenny, Lesley J

    2003-03-01

    This article describes the use of a creative thinking game to stimulate critical thinking and reflection with qualified health professionals undertaking palliative care education. The importance of reflective practice in nursing is well documented and numerous models are available. However, the author as a nurse teacher has found that many of these models are either too simple or too complex to be valuable in practice. The six hats game, devised by Edward de Bono, is a method that stimulates a variety of types of thinking and when used as a means of reflection helps students to become more critical about their practice. Using this game with a palliative care case study the author demonstrates how thinking more creatively about the patients' perceived needs and problems can assist in developing reflective skills. The article concludes with a discussion on some of the challenges of using this method and suggestions for future practical uses.

  11. "It's your badge of inclusion": the Red Hat Society as a gendered subculture of aging.

    PubMed

    Barrett, Anne E; Pai, Manacy; Redmond, Rebecca

    2012-12-01

    Although studies document the health-enhancing effects of social engagement, they reveal little about the underlying mechanisms operating within specific organizational contexts. Limited attention is given to the role of inequality--particularly age and gender--in shaping either the organizations to which we belong or their consequences for our well-being. We address this issue by examining the Red Hat Society, a social organization for middle-aged and older women. Interviews with members (n=52) illustrate how age and gender inequality interact to shape the organization, which can be viewed as a gendered subculture of aging. Drawing on this framework, we discuss four processes through which participation generates benefits for older women involved in age- and gender-segregated organizations: enhancing social networks, countering invisibility, creating positive frames for aging experiences, and promoting youthful identities.

  12. The Effect of Six Thinking Hats on Student Success in Teaching Subjects Related to Sustainable Development in Geography Classes

    ERIC Educational Resources Information Center

    Kaya, Mehmet Fatih

    2013-01-01

    This study aimed to assess the effectiveness of six thinking hats technique in teaching subjects related to sustainable development in geography classes. The study was in both a quantitative and qualitative form. The quantitative part of the study was designed according to pre-test, post-test control group research model, and in the qualitative…

  13. Inhibition of Different Histone Acetyltransferases (HATs) Uncovers Transcription-Dependent and -Independent Acetylation-Mediated Mechanisms in Memory Formation

    ERIC Educational Resources Information Center

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-01-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

  14. Survey of sugar beet (Beta vulgaris L.) hAT transposons and MITE-like hATpin derivatives.

    PubMed

    Menzel, Gerhard; Krebs, Carmen; Diez, Mercedes; Holtgräwe, Daniela; Weisshaar, Bernd; Minoche, André E; Dohm, Juliane C; Himmelbauer, Heinz; Schmidt, Thomas

    2012-03-01

    Genome-wide analyses of repetitive DNA suggest a significant impact particularly of transposable elements on genome size and evolution of virtually all eukaryotic organisms. In this study, we analyzed the abundance and diversity of the hAT transposon superfamily of the sugar beet (B. vulgaris) genome, using molecular, bioinformatic and cytogenetic approaches. We identified 81 transposase-coding sequences, three of which are part of structurally intact but nonfunctional hAT transposons (BvhAT), in a B. vulgaris BAC library as well as in whole genome sequencing-derived data sets. Additionally, 116 complete and 497 truncated non-autonomous BvhAT derivatives lacking the transposase gene were in silico-detected. The 116 complete derivatives were subdivided into four BvhATpin groups each characterized by a distinct terminal inverted repeat motif. Both BvhAT and BvhATpin transposons are specific for species of the genus Beta and closely related species, showing a localization on B. vulgaris chromosomes predominantely in euchromatic regions. The lack of any BvhAT transposase function together with the high degree of degeneration observed for the BvhAT and the BvhATpin genomic fraction contrasts with the abundance and activity of autonomous and non-autonomous hAT transposons revealed in other plant species. This indicates a possible genus-specific structural and functional repression of the hAT transposon superfamily during Beta diversification and evolution.

  15. Development of a helmet/helmet-display-unit alignment tool (HAT) for the Apache helmet and display unit

    NASA Astrophysics Data System (ADS)

    McLean, William; Statz, Jonathan; Estes, Victor; Booms, Shawn; Martin, John S.; Harding, Thomas

    2015-05-01

    Project Manager (PM) Apache Block III contacted the U.S. Army Aeromedical Research Laboratory (USAARL), Fort Rucker, Alabama, requesting assistance to evaluate and find solutions to a government-developed Helmet Display Unit (HDU) device called the Mock HDU for helmet alignment of the Apache Advanced Integrated Helmet (AAIH). The AAIH is a modified Head Gear Unit No. 56 for Personnel (HGU-56/P) to replace the current Integrated Helmet and Sighting System (IHADSS). The current flashlight-based HDU simulator for helmet/HDU alignment was no longer in production or available. Proper helmet/HDU alignment is critical to position the right eye in the small HDU eye box to obtain image alignment and full field of view (FOV). The initial approach of the PM to developing a helmet/HDU fitting device (Mock HDU) was to duplicate the optical characteristics of the current tactical HDU using less complex optics. However, the results produced questionable alignment, FOV, and distortion issues, with cost and development time overruns. After evaluating the Mock HDU, USAARL proposed a cost effective, less complex optical design called the Helmet/HDU Alignment Tool (HAT). This paper will show the development, components, and evaluations of the HAT compared to the current flashlight HDU simulator device. The laboratory evaluations included FOV measurements and alignment accuracies compared to tactical HDUs. The Apache helmet fitter technicians and Apache pilots compared the HAT to the current flashlight based HDU and ranked the HAT superior.

  16. SPITZER IRAC SECONDARY ECLIPSE PHOTOMETRY OF THE TRANSITING EXTRASOLAR PLANET HAT-P-1b

    SciTech Connect

    Todorov, Kamen; Deming, Drake; Harrington, Jospeph; Stevenson, Kevin B.; Bowman, William C.; Nymeyer, Sarah; Fortney, Jonathan J.; Bakos, Gaspar A.

    2010-01-01

    We report Spitzer/IRAC photometry of the transiting giant exoplanet HAT-P-1b during its secondary eclipse. This planet lies near the postulated boundary between the pM and pL-class of hot Jupiters, and is important as a test of models for temperature inversions in hot Jupiter atmospheres. We derive eclipse depths for HAT-P-1b, in units of the stellar flux, that are: 0.080% +- 0.008% [3.6 mum], 0.135% +- 0.022% [4.5 mum], 0.203% +- 0.031% [5.8 mum], and 0.238% +- 0.040% [8.0 mum]. These values are best fit using an atmosphere with a modest temperature inversion, intermediate between the archetype inverted atmosphere (HD 209458b) and a model without an inversion. The observations also suggest that this planet is radiating a large fraction of the available stellar irradiance on its dayside, with little available for redistribution by circulation. This planet has sometimes been speculated to be inflated by tidal dissipation, based on its large radius in discovery observations, and on a non-zero orbital eccentricity allowed by the radial velocity data. The timing of the secondary eclipse is very sensitive to orbital eccentricity, and we find that the central phase of the eclipse is 0.4999 +- 0.0005. The difference between the expected and observed phase indicates that the orbit is close to circular, with a 3sigma limit of |e cos omega| < 0.002.

  17. Pharmacogenetic Association of Hypertension Candidate Genes with Fasting Glucose in the GenHAT Study

    PubMed Central

    Irvin, Marguerite R.; Lynch, Amy I.; Kabagambe, Edmond K.; Tiwari, Hemant K.; Barzilay, Joshua I.; Eckfeldt, John H.; Boerwinkle, Eric; Davis, Barry R.; Ford, Charles E.; Arnett, Donna K.

    2010-01-01

    Several clinical studies report increased risk of diabetes mellitus (DM) with pharmacologic treatment for hypertension (HTN). HTN genes may modify glycemic response to antihypertensive treatment. The current study examined the association of 24 single nucleotide polymorphisms (SNPs) in 11 HTN candidate genes with fasting glucose measured at 2, 4, and 6 years after treatment initiation. The study sample included participants free of diabetes at baseline in the Genetics of Hypertension Associated Treatment (GenHAT) study (N=9,309). GenHAT participants were randomized to receive treatment with a diuretic (chlorthalidone), calcium channel blocker (amlodipine), or ACE inhibitor (lisinopril). Mixed models for repeated measures were employed to test for gene and pharmacogenetic associations with fasting glucose during follow-up. Fasting glucose at year 2 increased on average 6.8 mg/dL, 4.8 mg/dL and 3.0 mg/dL from baseline in the chlorthalidone, amlodipine and lisinopril groups, respectively. Carrying the I allele (rs1799752) of the angiotensin-converting enzyme (ACE) I/D polymorphism was associated with lower fasting glucose levels (P=0.02). Additionally, an ACE promoter polymorphism (−262, rs4291) was associated with lower fasting glucose for the model AA/AT vs. TT which remained significant after correction for multiple testing (P=0.001). Finally, a SNP in the α-subunit of the amiloride-sensitive epithelial sodium channel (SCNN1A, rs2228576) modified the association of amlodipine versus chlorthalidone treatment with fasting glucose (P<0.001). Further examination of these genes and their relationships with cardiometabolic disease could foster development of pharmacogenetic guidelines aimed to prevent increases in fasting glucose during antihypertensive treatment. PMID:20577119

  18. HATS-3b: An Inflated Hot Jupiter Transiting an F-type Star

    NASA Astrophysics Data System (ADS)

    Bayliss, D.; Zhou, G.; Penev, K.; Bakos, G. Á.; Hartman, J. D.; Jordán, A.; Mancini, L.; Mohler-Fischer, M.; Suc, V.; Rabus, M.; Béky, B.; Csubry, Z.; Buchhave, L.; Henning, T.; Nikolov, N.; Csák, B.; Brahm, R.; Espinoza, N.; Noyes, R. W.; Schmidt, B.; Conroy, P.; Wright, D. J.; Tinney, C. G.; Addison, B. C.; Sackett, P. D.; Sasselov, D. D.; Lázár, J.; Papp, I.; Sári, P.

    2013-11-01

    We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V = 12.4 F dwarf star. HATS-3b has a period of P = 3.5479 days, mass of Mp = 1.07 M J, and radius of Rp = 1.38 R J. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsin i = 9.0 km s-1), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low-/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces log g and T eff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km s-1. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), and the Australian National University (ANU). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with collaborators at the Pontificia Universidad Católica de Chile (PUC), the station at the High Energy Spectroscopic Survey (HESS) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU.

  19. The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

    PubMed Central

    Tscherner, Michael; Zwolanek, Florian; Jenull, Sabrina; Sedlazeck, Fritz J.; Petryshyn, Andriy; Frohner, Ingrid E.; Mavrianos, John; Chauhan, Neeraj; von Haeseler, Arndt; Kuchler, Karl

    2015-01-01

    Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a novel role for the chromatin assembly-associated histone acetyltransferase complex NuB4 in regulating oxidative stress resistance, antifungal drug tolerance and virulence in C. albicans. Strikingly, depletion of the NuB4 catalytic subunit, the histone acetyltransferase Hat1, markedly increases resistance to oxidative stress and tolerance to azole antifungals. Hydrogen peroxide resistance in cells lacking Hat1 results from higher induction rates of oxidative stress gene expression, accompanied by reduced histone density as well as subsequent increased RNA polymerase recruitment. Furthermore, hat1Δ/Δ cells, despite showing growth defects in vitro, display reduced susceptibility to reactive oxygen-mediated killing by innate immune cells. Thus, clearance from infected mice is delayed although cells lacking Hat1 are severely compromised in killing the host. Interestingly, increased oxidative stress resistance and azole tolerance are phenocopied by the loss of histone chaperone complexes CAF-1 and HIR, respectively, suggesting a central role for NuB4 in the delivery of histones destined for chromatin assembly via distinct pathways. Remarkably, the oxidative stress phenotype of hat1Δ/Δ cells is a species-specific trait only found in C. albicans and members of the CTG clade. The reduced azole susceptibility appears to be conserved in a wider range of fungi. Thus, our work demonstrates how highly conserved chromatin assembly pathways can acquire new functions in pathogenic fungi during coevolution with the host. PMID:26473952

  20. Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; Nascimbeni, V.; Weingrill, J.; von Essen, C.; Strassmeier, K. G.; Piotto, G.; Pagano, I.; Scandariato, G.; Csizmadia, Sz.; Herrero, E.; Sada, P. V.; Dhillon, V. S.; Marsh, T. R.; Künstler, A.; Bernt, I.; Granzer, T.

    2015-11-01

    Context. The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. Aims: We want to investigate the atmosphere of the hot Jupiter HAT-P-12b for an increased absorption at the very blue wavelength regions caused by scattering. Furthermore, we aim for a refinement of the transit parameters and the orbital ephemeris. Methods: We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. Results: We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit parameters, the ephemeris and perform a TTV analysis in which we found no indication for an unseen companion. The host star showed a mild non-periodic variability of up to 1%. However, no stellar rotation period could be detected to high confidence.

  1. Structure of the Hat Creek graben region: Implications for the structure of the Hat Creek graben and transfer of right-lateral shear from the Walker Lane north of Lassen Peak, northern California, from gravity and magnetic anomalies

    USGS Publications Warehouse

    Langenheim, Victoria; Jachens, Robert C.; Clynne, Michael A.; Muffler, L. J. Patrick

    2016-01-01

    Interpretation of magnetic and new gravity data provides constraints on the geometry of the Hat Creek Fault, the amount of right-lateral offset in the area between Mt. Shasta and Lassen Peak, and confirmation of the influence of pre-existing structure on Quaternary faulting. Neogene volcanic rocks coincide with short-wavelength magnetic anomalies of both normal and reversed polarity, whereas a markedly smoother magnetic field occurs over the Klamath Mountains and its Paleogene cover. Although the magnetic field over the Neogene volcanic rocks is complex, the Hat Creek Fault, which is one of the most prominent normal faults in the region and forms the eastern margin of the Hat Creek Valley, is marked by the eastern edge of a north-trending magnetic and gravity high 20-30 km long. Modeling of these anomalies indicates that the fault is a steeply dipping (~75-85°) structure. The spatial relationship of the fault as modeled by the potential-field data, the youngest strand of the fault, and relocated seismicity suggests that deformation continues to step westward across the valley, consistent with a component of right-lateral slip in an extensional environment. Filtered aeromagnetic data highlight a concealed magnetic body of Mesozoic or older age north of Hat Creek Valley. The body’s northwest margin strikes northeast and is linear over a distance of ~40 km. Within the resolution of the aeromagnetic data (1-2 km), we discern no right-lateral offset of this body. Furthermore, Quaternary faults change strike or appear to end, as if to avoid this concealed magnetic body and to pass along its southeast edge, suggesting that pre-existing crustal structure influenced younger faulting, as previously proposed based on gravity data.

  2. Analysis of Oceanic Internal Tides With PEZ-HAT, a Data-Assimilating Primitive Equations Model

    NASA Astrophysics Data System (ADS)

    Zaron, E. D.

    2006-12-01

    A software system for the generalized inversion of a primitive equations model has been developed and is currently being used to analyze the internal tides along the Hawaiian Ridge. The development of this system was facilitated by "The Inverse Ocean Model," a modular system that implements Weak-constraint, Four-Dimensional Variational (W4DVAR) assimilation for any dynamical model and observing array, both of which may be nonlinear but functionally smooth. The primitive equations, tangent-linear, and adjoint systems are solved in the frequency domain for this tidal application, and I will give an overview of their implementations, including the model forcing error convolutions. As an illustrative application, I will show results of assimilating HF-radar data into a regional model of the Kauai Channel, a site of intense conversion of barotropic to baroclinic tidal energy.

  3. A Damage Tolerance Comparison of Composite Hat-Stiffened and Honeycomb Sandwich Structure for Launch Vehicle Interstage Applications

    NASA Technical Reports Server (NTRS)

    Nettles, A. T.

    2011-01-01

    In this study, a direct comparison of the compression-after-impact (CAI) strength of impact-damaged, hat-stiffened and honeycomb sandwich structure for launch vehicle use was made. The specimens used consisted of small substructure designed to carry a line load of approx..3,000 lb/in. Damage was inflicted upon the specimens via drop weight impact. Infrared thermography was used to examine the extent of planar damage in the specimens. The specimens were prepared for compression testing to obtain residual compression strength versus damage severity curves. Results show that when weight of the structure is factored in, both types of structure had about the same CAI strength for a given damage level. The main difference was that the hat-stiffened specimens exhibited a multiphase failure whereas the honeycomb sandwich structure failed catastrophically.

  4. Compressive Strength of 24S-T Aluminum-alloy Flat Panels with Longitudinal Formed Hat-section Stiffeners

    NASA Technical Reports Server (NTRS)

    Schuette, Evan H; Barab, Sual; Mccracken, Howard L

    1946-01-01

    Results are presented for a part of a test program on 24S-T aluminum alloy flat compression panels with longitudinal formed hat-section stiffeners. This part of the program is concerned with panels in which the thickness of the stiffener materials is 0.625 times the skin thickness. The results, presented in tabular and graphical form, show the effect of the relative dimensions of the panel on the buckling stress and the average stress at maximum load. Comparative envelope curves are presented for hat-stiffened and Z-stiffened panels having the same ratio of stiffener thickness to sheet thickness. These curves provide some indication of the relative structural efficiencies of the two types of panel.

  5. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

    PubMed

    Hickman, Alison B; Ewis, Hosam E; Li, Xianghong; Knapp, Joshua A; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W; Craig, Nancy L; Dyda, Fred

    2014-07-17

    Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple nonspecific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA.

  6. Design and evaluation of a foam-filled hat-stiffened panel concept for aircraft primary structural applications

    NASA Technical Reports Server (NTRS)

    Ambur, Damodar R.

    1995-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as stiffener core has been designed for aircraft primary structural applications. This stiffener concept utilizes a manufacturing process that can be adapted readily to grid-stiffened structural configurations which possess inherent damage tolerance characteristics due to their multiplicity of load paths. The foam-filled hat-stiffener concept in a prismatically stiffened panel configuration is more efficient than most other stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The prismatically stiffened panel concept investigated here has been designed using AS4/3502 preimpregnated tape and Rohacell foam core and evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimens suggest that this structural concept responds to loading as anticipated and has good damage tolerance characteristics.

  7. Bayesian estimation inherent in a Mexican-hat-type neural network.

    PubMed

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  8. Sampling of BTX in Hat Yai city using cost effective laboratory-built PCB passive sampler.

    PubMed

    Subba, Jas Raj; Thammakhet, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya

    2016-08-23

    A laboratory-built printed circuit board (PCB) passive sampler used for the monitoring of xylene and styrene in copy print shops was re-validated for detecting benzene, toluene and xylene (BTX) and applied for the sampling of ambient air from Hat Yai city, Songkhla, Thailand, in the month of November 2014. For monitoring, the PCB passive samplers were exposed to target analytes in 16 locations covering high to low exposure areas. After sampling, the samplers were thermally desorbed and the analytes were trapped by multi-walled carbon nanotubes packed into a micro-preconcentrator coupled to a gas chromatograph (GC) equipped with a flame ionization detector. At the optimum GC operating conditions, the linear dynamic ranges for BTX were 0.06-5.6 µg for benzene, 0.07-2.2 µg for toluene and 0.23-2.5 µg for xylene with R(2) > 0.99 with the limits of detection being 6.6, 6.8 and 19 ng for benzene, toluene and xylene, respectively. The concentrations of BTX in the 16 sampling sites were in the range of N.D.-1.3 ± 1.6, 4.50 ± 0.76-49.6 ± 3.7 and 1.00 ± 0.21-39.6 ± 3.1 µg m(-3), respectively. When compared to past studies, there had been an increase in the benzene concentration. PMID:27231039

  9. Improved hole-transporting property via HAT-CN for perovskite solar cells without lithium salts.

    PubMed

    Ma, Yingzhuang; Chung, Yao-Hsien; Zheng, Lingling; Zhang, Danfei; Yu, Xiao; Xiao, Lixin; Chen, Zhijian; Wang, Shufeng; Qu, Bo; Gong, Qihuang; Zou, Dechun

    2015-04-01

    A nonadditive hole-transporting material (HTM) of a triphenylamine derivative of N,N'-di(3-methylphenyl)-N,N'-diphenyl-4,4'-diaminobiphenyl (TPD) is used for the organic-inorganic hybrid perovskite solar cells. The power conversion efficiency (PCE) can be significantly enhanced by inserting a thin layer of 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HAT-CN) without adding an ion additive because the hole-transporting properties improve. The short-circuit current density (J(sc)) increases from 8.5 to 13.1 mA/cm(2), the open-circuit voltage (V(oc)) increases from 0.84 to 0.92 V, and the fill-factor (FF) increases from 0.45 to 0.59, which corresponds to the increase in PCE from 3.2% to 7.1%. Moreover, the PCE decreases by only 10% after approximately 1000 h without encapsulation, which suggests an alternative method to improve the stability of perovskite solar cells. PMID:25761404

  10. Bayesian estimation inherent in a Mexican-hat-type neural network

    NASA Astrophysics Data System (ADS)

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  11. Confrontation of top-hat spherical collapse against dark halos from cosmological N-body simulations

    NASA Astrophysics Data System (ADS)

    Suto, Daichi; Kitayama, Tetsu; Osato, Ken; Sasaki, Shin; Suto, Yasushi

    2016-02-01

    The top-hat spherical collapse model (TSC) is one of the most fundamental analytical frameworks to describe the non-linear growth of cosmic structure. TSC has motivated, and been widely applied in, various investigations even in the current era of precision cosmology. While numerous studies exist to examine its validity against numerical simulations in a statistical fashion, there are few analyses which compare the TSC dynamics in an individual object-wise basis, which is what we attempt in the present paper. We extract 100 halos at z = 0 from a cosmological N-body simulation according to the conventional TSC criterion for the spherical over-density. Then we trace back their spherical counterparts at earlier epochs. Just prior to the turn-around epoch of the halos, their dynamics are well approximated by TSC, but their turn-around epochs are systematically delayed and the virial radii are larger by ˜20% on average relative to the TSC predictions. We find that this systematic deviation can mainly be ascribed to the non-uniformity/inhomogeneity of dark matter density profiles and the non-zero velocity dispersions, both of which are neglected in TSC. In particular, the inside-out collapse and shell-crossing of dark matter halos play an important role in generating the significant velocity dispersion. The implications of the present result are briefly discussed.

  12. Stellar rotation-planetary orbit period commensurability in the HAT-P-11 system

    SciTech Connect

    Béky, Bence; Holman, Matthew J.; Noyes, Robert W.; Kipping, David M.

    2014-06-10

    A number of planet host stars have been observed to rotate with a period equal to an integer multiple of the orbital period of their close planet. We expand this list by analyzing Kepler data of HAT-P-11 and finding a period ratio of 6:1. In particular, we present evidence for a long-lived spot on the stellar surface that is eclipsed by the planet in the same position four times, every sixth transit. We also identify minima in the out-of-transit light curve and confirm that their phase with respect to the stellar rotation is mostly stationary for the 48 month time frame of the observations, confirming the proposed rotation period. For comparison, we apply our methods to Kepler-17 and confirm the findings of Bonomo and Lanza that the period ratio is not exactly 8:1 in that system. Finally, we provide a hypothesis on how interactions between a star and its planet could possibly result in an observed commensurability for systems where the stellar differential rotation profile happens to include a period at some latitude that is commensurable to the planetary orbit.

  13. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix E. Final report

    SciTech Connect

    1988-07-01

    This document provides Appendix E of the Remedial Action Plan (RAP) presented in 1988 for the stabilization of the inactive uranium mill tailings at the Mexican Hat, Utah site. The RAP was developed to serve a two- fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by the DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. The RAP has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action.

  14. HAT-P-16b: A 4 M {sub J} PLANET TRANSITING A BRIGHT STAR ON AN ECCENTRIC ORBIT ,

    SciTech Connect

    Buchhave, L. A.; Bakos, G. A.; Hartman, J. D.; Torres, G.; Latham, D. W.; Noyes, R. W.; Esquerdo, G. A.; Everett, M.; Furesz, G.; Perumpilly, G.; Sasselov, D. D.; Stefanik, R. P.; Beky, B.; Kovacs, G.; Howard, A. W.; Marcy, G. W.; Fischer, D. A.; Johnson, J. A.; Andersen, J.; Lazar, J.

    2010-09-10

    We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 {+-} 0.000003 days, transit epoch T{sub c} = 2455027.59293 {+-} 0.00031 (BJD{sup 10}), and transit duration 0.1276 {+-} 0.0013 days. The host star has a mass of 1.22 {+-} 0.04 M{sub sun}, radius of 1.24 {+-} 0.05 R{sub sun}, effective temperature 6158 {+-} 80 K, and metallicity [Fe/H] = +0.17 {+-} 0.08. The planetary companion has a mass of 4.193 {+-} 0.094 M{sub J} and radius of 1.289 {+-} 0.066 R {sub J}, yielding a mean density of 2.42 {+-} 0.35 g cm{sup -3}. Comparing these observed characteristics with recent theoretical models, we find that HAT-P-16b is consistent with a 1 Gyr H/He-dominated gas giant planet. HAT-P-16b resides in a sparsely populated region of the mass-radius diagram and has a non-zero eccentricity of e = 0.036 with a significance of 10{sigma}.

  15. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

    PubMed

    Sadler, Anthony J; Suliman, Bandar A; Yu, Liang; Yuan, Xiangliang; Wang, Die; Irving, Aaron T; Sarvestani, Soroush T; Banerjee, Ashish; Mansell, Ashley S; Liu, Jun-Ping; Gerondakis, Steve; Williams, Bryan R G; Xu, Dakang

    2015-04-13

    To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be shown to rival phosphorylation in its importance in mediating cellular responses. However, limited instances have been identified. Here we show that signalling from Toll-like or TNF-α receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-κB p50 subunit that limits the NF-κB response. Accordingly, diminishing the activity of CaMK2, the expression levels of PLZF or HAT1, or mutating key residues that are covalently modified in PLZF and HAT1, curtails control of the production of inflammatory cytokines. These results identify a central role for acetylation in controlling the inflammatory NF-κB transcriptional programme.

  16. TASTE IV: Refining ephemeris and orbital parameters for HAT-P-20b and WASP-1b

    NASA Astrophysics Data System (ADS)

    Granata, V.; Nascimbeni, V.; Piotto, G.; Bedin, L. R.; Borsato, L.; Cunial, A.; Damasso, M.; Malavolta , L.

    2014-10-01

    We present four new light curves of the transiting exoplanets WASP-1b and HAT-P-20b, observed within the TASTE ({The Asiago Search for Transit timing variations of Exoplanets}) project. We re-analyzed light curves from the literature in a homogeneous way, calculating a refined ephemeris and orbital-physical parameters for both objects. WASP-1b does not show any significant Transit Timing Variation signal at the 120 s level. As for HAT-P-20b, we detected a deviation from our re-estimated linear ephemeris that could be ascribed to the presence of a perturber or, more probably, to a previously unnoticed high level of stellar activity. The rotational period of HAT-P-20 A that we obtained from archival data ({P_rot≃ 14.5} d), combined with its optical variability and strong emission of Ca II H & K lines, is consistent with a young stellar age ({< 1} Gyr) and support the hypothesis that stellar activity may be responsible of the measured deviations of the transit times.

  17. Energy versus centrality dependence of the jet quenching parameter hat{q} at RHIC and LHC: a new puzzle?

    NASA Astrophysics Data System (ADS)

    Andrés, Carlota; Armesto, Néstor; Luzum, Matthew; Salgado, Carlos A.; Zurita, Pía

    2016-09-01

    The central goal of jet quenching studies in high-energy nuclear collisions is the characterization of those QCD medium properties that are accessible by these probes. Most of the discussion in the last years has been focused on the determination of the jet quenching parameter, hat{q}. We present here an extraction of this parameter using data of inclusive particle suppression at RHIC and LHC energies for different centralities. Our approach consists in fitting a K factor that quantifies the departure of this parameter from an ideal estimate, K≡ hat{q}/(2ɛ ^{3/4}), where hat{q} is determined by the local medium quantities as provided by hydrodynamical calculations. We find that this K factor is larger at RHIC than at the LHC, as obtained already in previous analyses, but, surprisingly, it is almost independent of the centrality of the collision. Taken at face value, the K factor would not depend on the local properties of the medium as energy density or temperature, but on global collision quantities such as the center of mass energy. This is a very intriguing, unexpected possibility for which we cannot yet provide a clear interpretation. We also comment on the limitations of the formalism that may affect this conclusion.

  18. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

    PubMed

    Sadler, Anthony J; Suliman, Bandar A; Yu, Liang; Yuan, Xiangliang; Wang, Die; Irving, Aaron T; Sarvestani, Soroush T; Banerjee, Ashish; Mansell, Ashley S; Liu, Jun-Ping; Gerondakis, Steve; Williams, Bryan R G; Xu, Dakang

    2015-01-01

    To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be shown to rival phosphorylation in its importance in mediating cellular responses. However, limited instances have been identified. Here we show that signalling from Toll-like or TNF-α receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-κB p50 subunit that limits the NF-κB response. Accordingly, diminishing the activity of CaMK2, the expression levels of PLZF or HAT1, or mutating key residues that are covalently modified in PLZF and HAT1, curtails control of the production of inflammatory cytokines. These results identify a central role for acetylation in controlling the inflammatory NF-κB transcriptional programme. PMID:25865065

  19. HAT inhibitor, garcinol, exacerbates lipopolysaccharide‑induced inflammation in vitro and in vivo.

    PubMed

    Wang, Bin; Lin, Ling; Ai, Qing; Zeng, Tao; Ge, Pu; Zhang, Li

    2016-06-01

    Acetylation modification catalyzed by histone acetyl transferases (HATs) is important for transcriptional regulation. The present study investigated the effects of the HAT inhibitor garcinol on the expression of inflammation‑associated genes in lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophages and LPS‑challenged mice. The levels of pro‑inflammatory cytokines were determined by reverse transcription‑quantitative polymerase chain reaction and enzyme‑linked immunosorbent assay. The degree of multi‑organ injury was evaluated by histopathological examination of the lung, determination of the alanine aminotransferase and blood urea nitrogen in plasma samples and by monitoring the survival rate of the experimental animals. The results of the current study demonstrated that garcinol promoted LPS‑induced expression of tumor necrosis factor‑α (TNF‑α) and interleukin‑6 (IL‑6) in RAW264.7 cells. These effects were associated with reduced acetylation of nuclear factor‑κB p65. Additionally, treatment with garcinol enhanced LPS‑induced expression of TNF‑α and IL‑6, exacerbated LPS‑induced lung injury, increased LPS‑induced elevation of plasma alanine aminotransferase and blood urea nitrogen, and reduced the survival rate of LPS‑challenged mice. These data indicated that the HAT inhibitor, garcinol, enhances LPS‑induced inflammation in vitro and in vivo, suggesting that acetylation modification has an important regulatory function during inflammation. PMID:27122221

  20. Widefield imaging of upconverting nanoparticles on epifluorescence microscopes adapted for laser illumination with top-hat profile

    NASA Astrophysics Data System (ADS)

    Mrazek, Jiri; Pospisilova, Martina; Svozil, Vit; Cadek, Ondrej; Nesporova, Kristina; Sulakova, Romana; Brandejsova, Martina; Vranova, Jana; Velebny, Vladimir

    2016-05-01

    We describe a modification of epifluorescence microscopes that allows quantitative widefield imaging of samples labeled by upconverting nanoparticles (UCNP). A top-hat illumination profile on the sample was achieved with a 980-nm laser diode by using tandem microlens arrays, a moving diffuser and a telescope, which adjusts the top-hat area to the field of view. Illumination homogeneity is a critical factor for imaging of UCNP since the intensity of their luminescence typically scales with the second power of the excitation intensity. Our illuminator is combined with the epifluorescence attachment of the microscope, allowing easy switching between observation of UCNP and traditional fluorescent dyes. Illumination profile homogeneity of about 98% was measured for objectives with magnification from 4× to 100×, and the top-hat profile was also obtained with phase contrast objectives. We demonstrate capability of the illuminator by evaluating in vitro uptake of UCNP encapsulated in oleyl-hyaluronan micelles into breast cancer cells. Micelles bearing the targeting peptide were about an order of magnitude more efficient than nontargeted micelles.

  1. Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype*

    PubMed Central

    Purushothaman, Anurag; Hurst, Douglas R.; Pisano, Claudio; Mizumoto, Shuji; Sugahara, Kazuyuki; Sanderson, Ralph D.

    2011-01-01

    Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing expression of proteins known to drive tumor progression (e.g. VEGF, MMP-9, hepatocyte growth factor (HGF), and RANKL). However, the mechanism whereby this enzyme regulates gene expression remains unknown. We previously reported that elevation of heparanase levels in myeloma cells causes a dramatic reduction in the amount of syndecan-1 in the nucleus. Because syndecan-1 has heparan sulfate chains and because exogenous heparan sulfate has been shown to inhibit the activity of histone acetyltransferase (HAT) enzymes in vitro, we hypothesized that the reduction in nuclear syndecan-1 in cells expressing high levels of heparanase would result in increased HAT activity leading to stimulation of protein transcription. We found that myeloma cells or tumors expressing high levels of heparanase and low levels of nuclear syndecan-1 had significantly higher levels of HAT activity when compared with cells or tumors expressing low levels of heparanase. High levels of HAT activity in heparanase-high cells were blocked by SST0001, an inhibitor of heparanase. Restoration of high syndecan-1 levels in heparanase-high cells diminished nuclear HAT activity, establishing syndecan-1 as a potent inhibitor of HAT. Exposure of heparanase-high cells to anacardic acid, an inhibitor of HAT activity, significantly suppressed their expression of VEGF and MMP-9, two genes known to be up-regulated following elevation of heparanase. These results reveal a novel mechanistic pathway driven by heparanase expression, which leads to decreased nuclear syndecan-1, increased HAT activity, and up-regulation of transcription of multiple genes that drive an aggressive tumor phenotype. PMID:21757697

  2. Top hat single-mode polarization maintaining fiber and polarizing numerical design

    NASA Astrophysics Data System (ADS)

    Gouriou, Pierre; Scol, Florent; Sevigny, Benoit; Valentin, Constance; Quiquempois, Yves; Bigot, Laurent; Habert, Rémi; Cassez, Andy; Vanvincq, Olivier; Hugonnot, Emmanuel; Bouwmans, Geraud

    2016-03-01

    Compactness, long term stability and no free-space alignment are important advantages of fiber lasers over bulky systems. These fiber lasers have also demonstrated their capability to deliver high-power pulses and are thus suitable for numerous applications. Nevertheless the intensity profile delivered usually has a Gaussian-like shape, which most of the time is sufficient, but it could be interesting, for many applications (laser-biological tissues interactions, heat treatment, industrial laser processing or for seeding large-scale laser facilities like Laser MegaJoule) to obtain a homogeneous intensity profile at the fiber laser output. Moreover several of these applications required a linearly polarized output beam. In order to achieve all these requirements we have developed and realized a new fiber design. This fiber is the first polarization maintaining single-mode fiber delivering a flat top intensity. A high quality flat mode was obtained at 1.05μm through the use of a well-tailored index profile and single-mode behavior was verified by shifting the injection and using the S² imaging. Moreover, boron Stress Applying Parts (SAPs) including in the cladding led to a birefringence of 0.6x10-4 and a measured PER better than 20dB even for a long fiber length (~20 m). Alongside the fabrication, we developed a simulation code, using Comsol Multiphysics®, to take into account the stress dependency induced by the SAPs. Further modeling allows us to present an effectively single-mode fiber design, delivering a top-hat mode profile and exhibiting a polarizing behavior.

  3. THE SUB-SATURN MASS TRANSITING PLANET HAT-P-12b

    SciTech Connect

    Lee, Jae Woo; Youn, Jae-Hyuck; Kim, Seung-Lee; Lee, Chung-Uk; Hinse, Tobias Cornelius E-mail: jhyoon@kasi.re.kr E-mail: leecu@kasi.re.kr

    2012-04-15

    We present new photometric data of the transiting planet HAT-P-12b observed in 2011. Our three transit curves are modeled using the JKTEBOP code and adopting the quadratic limb-darkening law. Including our measurements, 18 transit times spanning about 4.2 yr were used to determine the improved ephemeris with a transit epoch of 2,454,187.85560 {+-} 0.00011 BJD and an orbital period of 3.21305961 {+-} 0.00000035 days. The physical properties of the star-planet system are computed using empirical calibrations from eclipsing binary stars and stellar evolutionary models, combined with both our transit parameters and previously known spectroscopic results. We found that the absolute dimensions of the host star are M{sub A} = 0.73 {+-} 0.02 M{sub Sun }, R{sub A} = 0.70 {+-} 0.01 R{sub Sun }, log g{sub A} = 4.61 {+-} 0.02, {rho}{sub A} = 2.10 {+-} 0.09 {rho}{sub Sun }, and L{sub A} = 0.21 {+-} 0.01 L{sub Sun }. The planetary companion has M{sub b} = 0.21 {+-} 0.01 M{sub Jup}, R{sub b} = 0.94 {+-} 0.01 R{sub Jup}, log g{sub b} = 2.77 {+-} 0.02, {rho}{sub b} = 0.24 {+-} 0.01 {rho}{sub Jup}, and T{sub eq} = 960 {+-} 14 K. Our results agree well with standard models of irradiated gas giants with a core mass of 11.3 M{sub Circled-Plus }.

  4. VizieR Online Data Catalog: Spectroscopy and photometry of HATS-17 (Brahm+, 2016)

    NASA Astrophysics Data System (ADS)

    Brahm, R.; Jordan, A.; Bakos, G. A.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lazar, J.; Papp, I.; Sari, P.

    2016-07-01

    The star HATS-17 was observed by HATSouth instruments between UT 2011 April 26 and UT 2012 July 31 using the HS-2 (on 2011 Apr-2012 Jul with r filter), HS-4 (on 2011 Jul-2012 Jul with r filter), and HS-6 (on 2011 May-2012 Jul with r filter) units at Las Campanas Observatory (LCO) in Chile, the High Energy Spectroscopic Survey (H.E.S.S.) site in Namibia, and Siding Spring Observatory (SSO) in Australia, respectively. The first photometric follow-up light curve of this system was obtained with the 0.3m Perth Exoplanet Survey Telescope (PEST) located near Perth on 2015 Apr 26 with a RC filter. Another two partial transits were then acquired with the Las Cumbres Observatory Global Telescope (LCOGT) 1m telescope network, specifically with the telescope at Cerro Tololo Inter-American Observatory (CTIO) on 2015 May 13 with i filter, and with the Swope 1m coupled with the e2v camera at Las Campanas Observatory (LCO) on 2015 May 29 with i filter. Finally, two partial transits of the same event were measured with high photometric precision (~1mmag). The observations were performed with the same two telescopes that registered the previous partial transits (Swope 1m/e2v (LCO) on 2015 Jul 17 with i filter, and LCOGT 1 m/sinistro (CTIO) on 2015 Jul 17 with i filter). Several high resolution spectra were acquired with three spectrographs installed in the ESO La Silla observatory. We obtained 11 spectra using HARPS at the ESO 3.6m telescope, 8 spectra using CORALIE, at the Euler 1.2m telescope and 2 spectra with FEROS at the MPG 2.2m telescope. Table2 provides the light curve data. Radial velocity and bisector span values are presented in Table3 with their corresponding uncertainties. (2 data files).

  5. Shaping the PSF to nearly top-hat profile: CHEOPS laboratory results

    NASA Astrophysics Data System (ADS)

    Magrin, Demetrio; Farinato, Jacopo; Umbriaco, Gabriele; Kumar Radhakrishnan Santhakumari, Kalyan; Bergomi, Maria; Dima, Marco; Greggio, Davide; Marafatto, Luca; Ragazzoni, Roberto; Viotto, Valentina; Munari, Matteo; Pagano, Isabella; Scandariato, Gaetano; Scuderi, Salvatore; Piotto, Giampaolo; Beck, Thomas; Benz, Willy; Broeg, Christopher; Cessa, Virginie; Fortier, Andrea; Piazza, Daniele

    2014-08-01

    Spreading the PSF over a quite large amount of pixels is an increasingly used observing technique in order to reach extremely precise photometry, such as in the case of exoplanets searching and characterization via transits observations. A PSF top-hat profile helps to minimize the errors contribution due to the uncertainty on the knowledge of the detector flat field. This work has been carried out during the recent design study in the framework of the ESA small mission CHEOPS. Because of lack of perfect flat-fielding information, in the CHEOPS optics it is required to spread the light of a source into a well defined angular area, in a manner as uniform as possible. Furthermore this should be accomplished still retaining the features of a true focal plane onto the detector. In this way, for instance, the angular displacement on the focal plane is fully retained and in case of several stars in a field these look as separated as their distance is larger than the spreading size. An obvious way is to apply a defocus, while the presence of an intermediate pupil plane in the Back End Optics makes attractive to introduce here an optical device that is able to spread the light in a well defined manner, still retaining the direction of the chief ray hitting it. This can be accomplished through an holographic diffuser or through a lenslet array. Both techniques implement the concept of segmenting the pupil into several sub-zones where light is spread to a well defined angle. We present experimental results on how to deliver such PSF profile by mean of holographic diffuser and lenslet array. Both the devices are located in an intermediate pupil plane of a properly scaled laboratory setup mimicking the CHEOPS optical design configuration.

  6. Beginnings of the Hat Creek Observatory and the 85-foot Telescope

    NASA Astrophysics Data System (ADS)

    Weaver, Harold

    1993-05-01

    The first course in radio astronomy at Berkeley was given by Ron Bracewell, a Visiting Professor of Astronomy in 1954/55. Convinced that radio astronomy had to be a part of the curriculum, a faculty committee recommended in 1955 that a solar radio observatory be built and operated by the Department. This original plan was modified, and I took on the task of building and operating a radio astronomy observatory for galactic studies. It was to have as its major telescope an 85-foot dish -- a large instrument for that time. The first two years were spent in writing reports, searching for funds, and investigating existing radio observatories. The Radio Astronomy Laboratory was officially established by the Regents in July, 1958. Costs of the project were shared by ONR and the University. The Hat Creek site was located in early 1959 after many site tests over much of northern California. The roads and the first buildings were completed in January, 1960. The first telescope, a thirty-three foot dish built in-house as a learning experience, was used for its initial observations in July, 1960. The 85-foot telescope was accepted and first used in June, 1962. Construction of the 85-foot was not without mishap. In October, 1960, the airhouse under which the dish was being constructed, was destroyed in a storm. It was necessary to build a new airhouse and completely resurface the dish, causing a long delay in delivery. The 85-foot telescope was born in a storm; it died in a storm in January, 1993, in its thirty-first year.

  7. Spin-Orbit Angles of Kepler-13Ab and HAT-P-7b from Gravity-darkened Transit Light Curves

    NASA Astrophysics Data System (ADS)

    Masuda, Kento

    2015-05-01

    Analysis of the transit light curve deformed by the stellar gravity darkening allows us to photometrically measure both components of the spin-orbit angle ψ, its sky projection λ and inclination of the stellar spin axis {{i}\\star }. In this paper, we apply the method to two transiting hot Jupiter systems monitored with the Kepler spacecraft, Kepler-13A and HAT-P-7. For Kepler-13A, we find {{i}\\star }=81{}^\\circ +/- 5{}^\\circ and \\psi =60{}^\\circ +/- 2{}^\\circ adopting the spectroscopic constraint λ = 58.°6 ± 2.°0 by Johnson et al. In our solution, the discrepancy between the above λ and that previously reported by Barnes et al. is solved by fitting both of the parameters in the quadratic limb-darkening law. We also report the temporal variation in the orbital inclination of Kepler-13Ab, d|cos \\{{i}orb}|/dt=(-7.0+/- 0.4)× {{10}-6} day{{s}-1}, providing further evidence for the spin-orbit precession in this system. By fitting the precession model to the time series of {{i}orb}, λ, and {{i}\\star } obtained with the gravity-darkened model, we constrain the stellar quadrupole moment {{J}2}=(6.1+/- 0.3)× {{10}-5} for our new solution, which is several times smaller than {{J}2}=(1.66+/- 0.08)× {{10}-4} obtained for the previous one. We show that the difference can be observable in the future evolution of λ, thus providing a possibility to test our solution with follow-up observations. The second target, HAT-P-7, is the first F-dwarf star analyzed with the gravity-darkening method. Our analysis points to a nearly pole-on configuration with \\psi =101{}^\\circ +/- 2{}^\\circ or 87{}^\\circ +/- 2{}^\\circ and the gravity-darkening exponent β consistent with 0.25. Such an observational constraint on β can be useful for testing the theory of gravity darkening.

  8. Groundwater evolution beneath Hat Yai, a rapidly developing city in Thailand

    NASA Astrophysics Data System (ADS)

    Lawrence, A. R.; Gooddy, D. C.; Kanatharana, P.; Meesilp, W.; Ramnarong, V.

    2000-09-01

    Many cities and towns in South and Southeast Asia are unsewered, and urban wastewaters are often discharged either directly to the ground or to surface-water canals and channels. This practice can result in widespread contamination of the shallow groundwater. In Hat Yai, southern Thailand, seepage of urban wastewaters has produced substantial deterioration in the quality of the shallow groundwater directly beneath the city. For this reason, the majority of the potable water supply is obtained from groundwater in deeper semi-confined aquifers 30-50 m below the surface. However, downward leakage of shallow groundwater from beneath the city is a significant component of recharge to the deeper aquifer, which has long-term implications for water quality. Results from cored boreholes and shallow nested piezometers are presented. The combination of high organic content of the urban recharge and the shallow depth to the water table has produced strongly reducing conditions in the upper layer and the mobilisation of arsenic. A simple analytical model shows that time scales for downward leakage, from the surface through the upper aquitard to the semi-confined aquifer, are of the order of several decades. Résumé. De nombreuses villes du sud et du sud-est de l'Asie ne possèdent pas de réseaux d'égouts et les eaux usées domestiques s'écoulent souvent directement sur le sol ou dans des canaux et des cours d'eau de surface. Ces pratiques peuvent provoquer une contamination dispersée de la nappe phréatique. A Hat Yai (sud de la Thaïlande), les infiltrations d'eaux usées domestiques sont responsables d'une détérioration notable de la qualité de la nappe phréatique directement sous la ville. Pour cette raison, la majorité de l'eau potable est prélevée dans des aquifères semi-captifs plus profonds, situés entre 30 et 50 m sous la surface. Cependant, une drainance à partir de la nappe phréatique sous la ville constitue une composante significative de la recharge

  9. Evolutionary origin of Rosaceae-specific active non-autonomous hAT elements and their contribution to gene regulation and genomic structural variation.

    PubMed

    Wang, Lu; Peng, Qian; Zhao, Jianbo; Ren, Fei; Zhou, Hui; Wang, Wei; Liao, Liao; Owiti, Albert; Jiang, Quan; Han, Yuepeng

    2016-05-01

    Transposable elements account for approximately 30 % of the Prunus genome; however, their evolutionary origin and functionality remain largely unclear. In this study, we identified a hAT transposon family, termed Moshan, in Prunus. The Moshan elements consist of three types, aMoshan, tMoshan, and mMoshan. The aMoshan and tMoshan types contain intact or truncated transposase genes, respectively, while the mMoshan type is miniature inverted-repeat transposable element (MITE). The Moshan transposons are unique to Rosaceae, and the copy numbers of different Moshan types are significantly correlated. Sequence homology analysis reveals that the mMoshan MITEs are direct deletion derivatives of the tMoshan progenitors, and one kind of mMoshan containing a MuDR-derived fragment were amplified predominately in the peach genome. The mMoshan sequences contain cis-regulatory elements that can enhance gene expression up to 100-fold. The mMoshan MITEs can serve as potential sources of micro and long noncoding RNAs. Whole-genome re-sequencing analysis indicates that mMoshan elements are highly active, and an insertion into S-haplotype-specific F-box gene was reported to cause the breakdown of self-incompatibility in sour cherry. Taken together, all these results suggest that the mMoshan elements play important roles in regulating gene expression and driving genomic structural variation in Prunus.

  10. Tectonic geomorphology and volcano-tectonic interaction in the eastern boundary of the Southern Cascades (Hat Creek Graben region), California, USA

    NASA Astrophysics Data System (ADS)

    Paguican, Engielle Mae; Bursik, Marcus

    2016-07-01

    The eastern boundary of the Southern Cascades (Hat Creek Graben region), California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The east-west extending region is in the transition zone between the convergence and subduction of the Gorda Plate underneath the North American Plate; north-south shortening within the Klamath Mountain region; and transcurrent movement in the Walker Lane. We describe the geomorphological and tectonic features, their alignment and distribution, in order to understand the tectonic geomorphology and volcano-tectonic relationships. One outcome of the work is a more refined morpho-structural description that will affect future hazard assessment in the area. A database of volcanic centers and structures was created from interpretations of topographic models generated from satellite images. Volcanic centers in the region were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the bigger and smaller edifices and revealed an evolutionary trend. Poisson Nearest Neighbor analysis shows that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6km of one another were found, revealing that preferential north-northwest directed pathways control the transport of magma from the source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater openings are perpendicular to the maximum horizontal stress, expected for extensional environments with dominant normal regional faults. These results imply that the extension of the Hat Creek Graben region and impingement of the Walker Lane is accommodated mostly by extensional faults and partly by the intrusions that formed the volcanoes. Early in the history of a volcano or volcano cluster, melt produced at depth in the region propagates

  11. STUDYING THE ATMOSPHERE OF THE EXOPLANET HAT-P-7b VIA SECONDARY ECLIPSE MEASUREMENTS WITH EPOXI, SPITZER, AND KEPLER

    SciTech Connect

    Christiansen, Jessie L.; Ballard, Sarah; Charbonneau, David; Holman, Matthew J.; Madhusudhan, Nikku; Seager, Sara; Wellnitz, Dennis D.; Deming, Drake; A'Hearn, Michael F.

    2010-02-10

    The highly irradiated transiting exoplanet, HAT-P-7b, currently provides one of the best opportunities for studying planetary emission in the optical and infrared wavelengths. We observe six near-consecutive secondary eclipses of HAT-P-7b at optical wavelengths with the EPOXI spacecraft. We place an upper limit on the relative eclipse depth of 0.055% (95% confidence). We also analyze Spitzer observations of the same target in the infrared, obtaining secondary eclipse depths of 0.098% +- 0.017%, 0.159% +- 0.022%, 0.245% +- 0.031%, and 0.225% +- 0.052% in the 3.6, 4.5, 5.8, and 8.0 {mu}m IRAC bands, respectively. We combine these measurements with the recently published Kepler secondary eclipse measurement and generate atmospheric models for the dayside of the planet that are consistent with both the optical and infrared measurements. The data are best fit by models with a temperature inversion, as expected from the high incident flux. The models predict a low optical albedo of {approx}<0.13, with subsolar abundances of Na, K, TiO, and VO. We also find that the best-fitting models predict that 10% of the absorbed stellar flux is redistributed to the nightside of the planet, which is qualitatively consistent with the inefficient day-night redistribution apparent in the Kepler phase curve. Models without thermal inversions fit the data only at the 1.25sigma level, and also require an overabundance of methane, which is not expected in the very hot atmosphere of HAT-P-7b. We also analyze the eight transits of HAT-P-7b present in the EPOXI data set and improve the constraints on the system parameters, finding a period of P = 2.2047308 +- 0.0000025 days, a stellar radius of R{sub *} = 1.824 +- 0.089 R{sub sun}, a planetary radius of R{sub p} = 1.342 +- 0.068 R{sub Jup}, and an inclination of i = 85.7{sup +3.5}{sub -2.2} deg.

  12. The GTC exoplanet transit spectroscopy survey. IV. Confirmation of the flat transmission spectrum of HAT-P-32b

    NASA Astrophysics Data System (ADS)

    Nortmann, L.; Pallé, E.; Murgas, F.; Dreizler, S.; Iro, N.; Cabrera-Lavers, A.

    2016-10-01

    We observed the hot Jupiter HAT-P-32b (also known as HAT-P-32Ab) to determine its optical transmission spectrum by measuring the wavelength-dependent, planet-to-star radius ratios in the region between 518-918 nm. We used the OSIRIS instrument at the Gran Telescopio CANARIAS (GTC) in long-slit spectroscopy mode, placing HAT-P-32 and a reference star in the same slit and obtaining a time series of spectra covering two transit events. Using the best quality data set, we were able to yield 20 narrowband transit light curves, with each passband spanning a 20 nm wide interval. After removal of all systematic noise signals and light curve modeling, the uncertainties for the resulting radius ratios lie between 337 and 972 ppm. The radius ratios show little variation with wavelength, suggesting a high altitude cloud layer masking any atmospheric features. Alternatively, a strong depletion in alkali metals or a much smaller than expected planetary atmospheric scale height could be responsible for the lack of atmospheric features. Our result of a flat transmission spectrum is consistent with a previous ground-based study of the optical spectrum of this planet. This agreement between independent results demonstrates that ground-based measurements of exoplanet atmospheres can give reliable and reproducible results despite the fact that the data often is heavily affected by systematic noise as long as the noise source is well understood and properly corrected. We also extract an optical spectrum of the M-dwarf companion HAT-P-32B. Using PHOENIX stellar atmosphere models we determine an effective temperature of Teff = 3187+60-71 K, which is slightly colder than previous studies relying only on broadband infrared data. The 20 narrowband and white light curves are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/594/A65

  13. INVESTIGATION OF SYSTEMATIC EFFECTS IN KEPLER DATA: SEASONAL VARIATIONS IN THE LIGHT CURVE OF HAT-P-7b

    SciTech Connect

    Van Eylen, V.; Lindholm Nielsen, M.; Hinrup, B.; Tingley, B.; Kjeldsen, H.

    2013-09-10

    With years of Kepler data currently available, the measurement of variations in planetary transit depths over time can now be attempted. To do so, it is of primary importance to understand which systematic effects may affect the measurement of transits. We aim to measure the stability of Kepler measurements over years of observations. We present a study of the depth of about 500 transit events of the Hot Jupiter HAT-P-7b, using 14 quarters (Q0-Q13) of data from the Kepler satellite. We find a systematic variation in the depth of the primary transit, related to quarters of data and recurring yearly. These seasonal variations are about 1%. Within seasons, we find no evidence for trends. We speculate that the cause of the seasonal variations could be unknown field crowding or instrumental artifacts. Our results show that care must be taken when combining transits throughout different quarters of Kepler data. Measuring the relative planetary radius of HAT-P-7b without taking these systematic effects into account leads to unrealistically low error estimates. This effect could be present in all Kepler targets. If so, relative radius measurements of all Hot Jupiters to a precision much better than 1% are unrealistic.

  14. Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex.

    PubMed

    Nguyen-Huynh, Nha-Thi; Sharov, Grigory; Potel, Clément; Fichter, Pélagie; Trowitzsch, Simon; Berger, Imre; Lamour, Valérie; Schultz, Patrick; Potier, Noëlle; Leize-Wagner, Emmanuelle

    2015-08-01

    Understanding the way how proteins interact with each other to form transient or stable protein complexes is a key aspect in structural biology. In this study, we combined chemical cross-linking with mass spectrometry to determine the binding stoichiometry and map the protein-protein interaction network of a human SAGA HAT subcomplex. MALDI-MS equipped with high mass detection was used to follow the cross-linking reaction using bis[sulfosuccinimidyl] suberate (BS3) and confirm the heterotetrameric stoichiometry of the specific stabilized subcomplex. Cross-linking with isotopically labeled BS3 d0-d4 followed by trypsin digestion allowed the identification of intra- and intercross-linked peptides using two dedicated search engines: pLink and xQuest. The identified interlinked peptides suggest a strong network of interaction between GCN5, ADA2B and ADA3 subunits; SGF29 is interacting with GCN5 and ADA3 but not with ADA2B. These restraint data were combined to molecular modeling and a low-resolution interacting model for the human SAGA HAT subcomplex could be proposed, illustrating the potential of an integrative strategy using cross-linking and mass spectrometry for addressing the structural architecture of multiprotein complexes.

  15. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    SciTech Connect

    Morris, Brett M.; Deming, Drake; Mandell, Avi M.

    2013-02-20

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase -0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is T{sub B} = 2733 {+-} 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately -0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  16. A Search for Water in the Atmosphere of HAT-P-26b Using LDSS-3C

    NASA Astrophysics Data System (ADS)

    Stevenson, Kevin B.; Bean, Jacob L.; Seifahrt, Andreas; Gilbert, Gregory J.; Line, Michael R.; Désert, Jean-Michel; Fortney, Jonathan J.

    2016-02-01

    The characterization of a physically diverse set of transiting exoplanets is an important and necessary step toward establishing the physical properties linked to the production of obscuring clouds or hazes. It is those planets with identifiable spectroscopic features that can most effectively enhance our understanding of atmospheric chemistry and metallicity. The newly commissioned LDSS-3C instrument on Magellan provides enhanced sensitivity and suppressed fringing in the red optical, thus advancing the search for the spectroscopic signature of water in exoplanetary atmospheres from the ground. Using data acquired by LDSS-3C and the Spitzer Space Telescope, we search for evidence of water vapor in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Our measured spectrum is best explained by the presence of water vapor, a lack of potassium, and either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ∼10 mbar. The emergence of multi-scale-height spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet’s atmospheric chemical abundances. We also update HAT-P-26b’s transit ephemeris, t0 = 2455304.65218(25) BJDTDB, and orbital period, p = 4.2345023(7) days.

  17. HAT-P-15b: A 10.9 DAY EXTRASOLAR PLANET TRANSITING A SOLAR-TYPE STAR

    SciTech Connect

    Kovacs, G.; Bakos, G. A.; Hartman, J. D.; Torres, G.; Noyes, R. W.; Latham, D. W.; Sasselov, D. D.; Stefanik, R. P.; Esquerdo, G. A.; Fernandez, J. M.; Howard, A. W.; Marcy, G. W.; Isaacson, H.; Fischer, D. A.; Johnson, J. A.; Lazar, B. Beky J.; Papp, I.; Sari, P.

    2010-12-01

    We report the discovery of HAT-P-15b, a transiting extrasolar planet in the 'period valley', a relatively sparsely populated period regime of the known extrasolar planets. The host star, GSC 2883-01687, is a G5 dwarf with V= 12.16. It has a mass of 1.01 {+-} 0.04 M{sub sun}, radius of 1.08 {+-} 0.04 R{sub sun}, effective temperature 5568 {+-} 90 K, and metallicity [Fe/H] = +0.22 {+-} 0.08. The planetary companion orbits the star with a period P = 10.863502 {+-} 0.000027 days, transit epoch T{sub c} = 2454638.56019 {+-} 0.00048 (BJD), and transit duration 0.2285 {+-} 0.0015 days. It has a mass of 1.946 {+-} 0.066 M{sub J} and radius of 1.072 {+-} 0.043 R{sub J} yielding a mean density of 1.96 {+-} 0.22 g cm{sup -3}. At an age of 6.8{sup +2.5}{sub -1.6} Gyr, the planet is H/He-dominated and theoretical models require about 2% (10 M{sub +}) worth of heavy elements to reproduce its measured radius. With an estimated equilibrium temperature of {approx}820 K during transit, and {approx}1000 K at occultation, HAT-P-15b is a potential candidate to study moderately cool planetary atmospheres by transmission and occultation spectroscopy.

  18. Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.

    PubMed

    Sreedharan, Jemeen; Neukomm, Lukas J; Brown, Robert H; Freeman, Marc R

    2015-08-17

    The RNA-processing protein TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron (MN) disease. TDP-43 is conserved in Drosophila, where it has been the topic of considerable study, but how TDP-43 mutations lead to age-dependent neurodegeneration is unclear and most approaches have not directly examined changes in MN morphology with age. We used a mosaic approach to study age-dependent MN loss in the adult fly leg where it is possible to resolve single motor axons, NMJs and active zones, and perform rapid forward genetic screens. We show that expression of TDP-43(Q331K) caused dying-back of NMJs and axons, which could not be suppressed by mutations that block Wallerian degeneration. We report the identification of three genes that suppress TDP-43 toxicity, including shaggy/GSK3, a known modifier of neurodegeneration. The two additional novel suppressors, hat-trick and xmas-2, function in chromatin modeling and RNA export, two processes recently implicated in human ALS. Loss of shaggy/GSK3, hat-trick, or xmas-2 does not suppress Wallerian degeneration, arguing TDP-43(Q331K)-induced and Wallerian degeneration are genetically distinct processes. In addition to delineating genetic factors that modify TDP-43 toxicity, these results establish the Drosophila adult leg as a valuable new tool for the in vivo study of adult MN phenotypes.

  19. ATMOSPHERE AND SPECTRAL MODELS OF THE KEPLER-FIELD PLANETS HAT-P-7b AND TrES-2

    SciTech Connect

    Spiegel, David S.; Burrows, Adam E-mail: burrows@astro.princeton.ed

    2010-10-10

    We develop atmosphere models of two of the three Kepler-field planets that were known prior to the start of the Kepler mission (HAT-P-7b and TrES-2). We find that published Kepler and Spitzer data for HAT-P-7b appear to require an extremely hot upper atmosphere on the dayside, with a strong thermal inversion and little day-night redistribution. The Spitzer data for TrES-2 suggest a mild thermal inversion with moderate day-night redistribution. We examine the effect of nonequilibrium chemistry on TrES-2 model atmospheres and find that methane levels must be adjusted by extreme amounts in order to cause even mild changes in atmospheric structure and emergent spectra. Our best-fit models to the Spitzer data for TrES-2 lead us to predict a low secondary eclipse planet-star flux ratio ({approx}<2 x 10{sup -5}) in the Kepler bandpass, which is consistent with what very recent observations have found. Finally, we consider how the Kepler-band optical flux from a hot exoplanet depends on the strength of a possible extra optical absorber in the upper atmosphere. We find that the optical flux is not monotonic in optical opacity, and the non-monotonicity is greater for brighter, hotter stars.

  20. HAT-P-56b: A bright highly inflated massive Hot Jupiter around An F star in K2.0 field

    NASA Astrophysics Data System (ADS)

    Huang, Xu; Bakos, Gaspar; Hartman, Joel

    2015-08-01

    We report the discovery of HAT-P-56b, a transiting high inflated hot-jupiter orbiting a F type star in the field 0 of the NASA K2 mission, by the HATNet survey. We combine ground-based photometric light curves with the highprecision photometry obervation by the K2 mission, as well as radial velocity to determine the physical properties of this system. HAT-P-56b has a mass around ~2.2 Mjunp, a radius of ~1.5 Rjup, and transits its host star with a period of 2.79d. The host star has a V band magnitude of 10.9, Mass of 1.29 Msun, and radius of 1.433 Rsun. The radius of HAT-P-56b is among one of the largest compare to planets with similar mass, making it an interesting target for following up atmospherical observations.

  1. Importance of energy and angular resolutions in top-hat electrostatic analysers for solar wind proton measurements

    NASA Astrophysics Data System (ADS)

    De Marco, R.; Marcucci, M. F.; Bruno, R.; D'Amicis, R.; Servidio, S.; Valentini, F.; Lavraud, B.; Louarn, P.; Salatti, M.

    2016-08-01

    We use a numerical code which reproduces the angular/energy response of a typical top-hat electrostatic analyser starting from solar wind proton velocity distribution functions (VDFs) generated by numerical simulations. The simulations are based on the Hybrid Vlasov-Maxwell numerical algorithm which integrates the Vlasov equation for the ion distribution function, while the electrons are treated as a fluid. A virtual satellite launched through the simulation box measures the particle VDFs. Such VDFs are moved from the simulation Cartesian grid to energy-angular coordinates to mimic the response of a real sensor in the solar wind. Different energy-angular resolutions of the analyser are investigated in order to understand the influence of the phase-space resolution in existing and upcoming space missions, with regards to determining the key parameters of plasma dynamics.

  2. VizieR Online Data Catalog: GTC transit light curves of HAT-P-32b (Nortmann+, 2016)

    NASA Astrophysics Data System (ADS)

    Nortmann, L.; Palle, E.; Murgas, F.; Dreizler, S.; Iro, N.; Cabrera-Lavers, A.

    2016-05-01

    We provide two transit light curves of the hot Jupiter HAT-P-32b obtained on the nights of 2012/09/15 and 2012/09/30 using the OSIRIS instrument at the 10.4-m GTC telescope. The data was obtained by using OSIRIS in broad slit spectroscopy mode and covering the wavelength region between 518nm-918nm. For the night of 2012/09/30 we further provide twenty narrowband light curves which were created by summing the flux over 20-nm-wide channels instead over the whole wavelength region. We provide several auxiliary parameters of the observations which we have used to correct the data from correlated noise. These auxiliary parameters are the position drift of the stars on the CCD detector in spatial and dispersion direction, air mass and seeing (FWHM). (23 data files).

  3. Classical and Mexican hat-type potential energy curve for the hydrogen molecule from a confined Kratzer oscillator

    NASA Astrophysics Data System (ADS)

    van Hooydonk, G.

    2016-03-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator can also lead to the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated by reducing PECs for different bonds H2, HF, I2, N2 and O2 to a single one. The equal probability for H2, originating either from HA + HB or HB + HA, is quantified with a Gauss probability density function. At the Bohr scale, a confined harmonic oscillator behaves properly at the extremes of bound two-nucleon quantum systems.

  4. LONG-TERM TRANSIT TIMING MONITORING AND REFINED LIGHT CURVE PARAMETERS OF HAT-P-13b

    SciTech Connect

    Fulton, Benjamin J.; Shporer, Avi; Winn, Joshua N.; Holman, Matthew J.; Pal, Andras; Zachary Gazak, J.

    2011-09-15

    We present 10 new transit light curves of the transiting hot Jupiter HAT-P-13b, obtained during two observational seasons by three different telescopes. When combined with 12 previously published light curves, we have a sample consisting of 22 transit light curves, spanning 1041 days across four observational seasons. We use this sample to examine the recently observed large-amplitude transit timing variations (TTVs) by Pal et al. and give refined system parameters. We find that the transit times are consistent with a linear ephemeris, with the exception of a single transit time, from UT 2009 November 5, for which the measured mid-transit time significantly deviates from our linear ephemeris. The nature of this deviation is not clear, and the rest of the data do not show any significant TTVs.

  5. Origin and potential geothermal significance of China Hat and other late Pleistocene topaz rhyolite lava domes of the Blackfoot Volcanic Field, SE Idaho

    NASA Astrophysics Data System (ADS)

    McCurry, M. O.; Pearson, D. M.; Welhan, J. A.; Kobs-Nawotniak, S. E.; Fisher, M. A.

    2014-12-01

    The Snake River Plain and neighboring regions are well known for their high heat flow and robust Neogene-Quaternary tectonic and magmatic activity. Interestingly, however, there are comparatively few surficial manifestations of geothermal activity. This study is part of a renewed examination of this region as a possible hidden or blind geothermal resource. We present a testable, integrated volcanological, petrogenetic, tectonic and hydrothermal conceptual model for 57 ka China Hat and cogenetic topaz rhyolite lava domes of the Blackfoot Volcanic Field. This field is well suited for analysis as a blind resource because of its distinctive combination of (1) young bimodal volcanism, petrogenetic evidence of shallow magma storage and evolution, presence of coeval extension, voluminous travertine deposits, and C- and He-isotopic evidence of active magma degassing; (2) a paucity of hot springs or other obvious indicators of a geothermal resource in the immediate vicinity of the lava domes; and (3) proximity to a region of high crustal heat flow, high-T geothermal fluids at 2.5-5 km depth and micro-seismicity characterized by its swarming nature. Eruptions of both basalt and rhyolite commonly evolve from minor phreatomagmatic to effusive. In our model, transport of both magmatic and possible deep crustal aqueous fluids may be controlled by preexisting crustal structures, including west-dipping thrust faults. Geochemical evolution of rhyolite magma is dominated by mid- to upper-crustal fractional crystallization (with pre-eruption storage and phenocryst formation at ~14 km). Approximately 1.2 km3 of topaz rhyolite have been erupted since 1.4 Ma, yielding an average eruption rate of 0.8 km3/m.y. Given reasonable assumptions of magma cumulate formation and eruption rates, and initial and final volatile concentrations, we infer average H2O and CO2 volatile fluxes from the rhyolite source region of ~2MT/year and 340 T/day, respectively. Lithium flux may be comparable to CO2.

  6. Antihypertensive Pharmacogenetic Effect of Fibrinogen-beta Variant -455 G>A on Cardiovascular Disease, End-Stage Renal Disease and Mortality: The GenHAT Study

    PubMed Central

    Lynch, Amy I.; Boerwinkle, Eric; Davis, Barry R.; Ford, Charles E.; Eckfeldt, John H.; Leiendecker-Foster, Catherine; Arnett, Donna K.

    2009-01-01

    Objective The FGB gene codes for fibrinogen-beta, a polypeptide of the coagulation factor fibrinogen, which is positively associated with cardiovascular diseases. Studies show ACE inhibitors lower plasma fibrinogen concentrations, whereas diuretics and calcium channel blockers do not. Since carriers of the FGB-455 minor “A” allele have higher levels of fibrinogen while ACE inhibitors lower it, we hypothesize that “A” allele carriers benefit more from antihypertensive treatment with ACE inhibitors than calcium channel blockers or diuretics, relative to “GG” genotype individuals. Methods The GenHAT study (ancillary to ALLHAT) genotyped hypertensive participants for several hypertension-related candidate genes, making this a post-hoc analysis of a randomized trial. In total, 90.1% of the ALLHAT population was successfully genotyped for FGB-455. We included participants (n=30,076) randomized to one of three antihypertensive medications (lisinopril, amlodipine, chlorthalidone), with two treatment comparisons: lisinopril versus chlorthalidone and lisinopril versus amlodipine. The primary outcome of ALLHAT/GenHAT was coronary heart disease, defined as fatal CHD or non-fatal MI, and secondary outcomes included stroke, heart failure, all-cause mortality and end-stage renal disease (ESRD) with mean follow-up time of 4.9 years. Genotype-by-treatment interactions (pharmacogenetic effects) were tested with Cox regression. Results Stroke: Common “GG” homozygotes had higher risk on lisinopril versus amlodipine (HR=1.38, p<0.001), while minor “A” allele carriers had slightly lower risk (HR=0.96, p=0.76; p-value for interaction=0.03). Mortality: “GG” homozygotes had higher risk on lisinopril versus amlodipine (HR=1.12, p=0.02) or chlorthalidone (1.05, p=0.23), while “A” allele carriers had slightly lower risk (HR=0.92, p=0.33 for lisinopril versus amlodipine, HR=0.88, p=0.08 for lisinopril versus chlorthalidone; p-value for interactions 0.04 and 0

  7. 3.6 and 4.5 μm Spitzer Phase Curves of the Highly Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    NASA Astrophysics Data System (ADS)

    Wong, Ian; Knutson, Heather A.; Kataria, Tiffany; Lewis, Nikole K.; Burrows, Adam; Fortney, Jonathan J.; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicolas B.; Deming, Drake; Désert, Jean-Michel; Fulton, Benjamin J.; Howard, Andrew W.; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P.; Todorov, Kamen

    2016-06-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 μm, obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of 0.485%+/- 0.024% and 0.584%+/- 0.029% at 3.6 and 4.5 μm, which are consistent with a single blackbody with effective temperature 2372 ± 60 K. The measured 3.6 and 4.5 μm secondary eclipse depths for HAT-P-7b are 0.156%+/- 0.009% and 0.190%+/- 0.006%, which are well described by a single blackbody with effective temperature 2667 ± 57 K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b’s dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day-night circulation. We also detect an eastward-shifted hotspot, which suggests the presence of a superrotating equatorial jet. In contrast, HAT-P-7b’s dayside emission suggests a dayside thermal inversion and relatively inefficient day-night circulation; no hotspot shift is detected. For both planets, these same models do not agree with the measured nightside emission. The discrepancies in the model-data comparisons for WASP-19b might be explained by high-altitude silicate clouds on the nightside and/or high atmospheric metallicity, while the very low 3.6 μm nightside planetary brightness for HAT-P-7b may be indicative of an enhanced global C/O ratio. We compute Bond albedos of 0.38 ± 0.06 and 0 (\\lt 0.08 at 1σ ) for WASP-19b and HAT-P-7b, respectively. In the context of other planets with thermal phase curve measurements, we show that WASP-19b and HAT-P-7b fit the general trend of decreasing day-night heat recirculation with increasing irradiation.

  8. Decision procedure for indefinite hypergeometric summation

    PubMed Central

    Gosper, R. William

    1978-01-01

    Given a summand an, we seek the “indefinite sum” S(n) determined (within an additive constant) by [Formula: see text] or, equivalently, by [Formula: see text] An algorithm is exhibited which, given an, finds those S(n) with the property [Formula: see text] With this algorithm, we can determine, for example, the three identities [Formula: see text] [Formula: see text] and [Formula: see text] and we can also conclude that [Formula: see text] is inexpressible as S(m) - S(0), for any S(n) satisfying Eq. 2. PMID:16592483

  9. A computational method for solving stochastic Itô–Volterra integral equations based on stochastic operational matrix for generalized hat basis functions

    SciTech Connect

    Heydari, M.H.; Hooshmandasl, M.R.; Maalek Ghaini, F.M.; Cattani, C.

    2014-08-01

    In this paper, a new computational method based on the generalized hat basis functions is proposed for solving stochastic Itô–Volterra integral equations. In this way, a new stochastic operational matrix for generalized hat functions on the finite interval [0,T] is obtained. By using these basis functions and their stochastic operational matrix, such problems can be transformed into linear lower triangular systems of algebraic equations which can be directly solved by forward substitution. Also, the rate of convergence of the proposed method is considered and it has been shown that it is O(1/(n{sup 2}) ). Further, in order to show the accuracy and reliability of the proposed method, the new approach is compared with the block pulse functions method by some examples. The obtained results reveal that the proposed method is more accurate and efficient in comparison with the block pule functions method.

  10. HAT-P-57b: A Short-period Giant Planet Transiting a Bright Rapidly Rotating A8V Star Confirmed Via Doppler Tomography

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bakos, G. Á.; Buchhave, L. A.; Torres, G.; Latham, D. W.; Kovács, G.; Bhatti, W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Huang, C. X.; Béky, B.; Bieryla, A.; Quinn, S. N.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Fischer, D. A.; Noyes, R. W.; Falco, E.; Esquerdo, G. A.; Knox, R. P.; Hinz, P.; Lázár, J.; Papp, I.; Sári, P.

    2015-12-01

    We present the discovery of HAT-P-57b, a P = 2.4653 day transiting planet around a V=10.465+/- 0.029 mag, {T}{{eff}}=7500+/- 250 K main sequence A8V star with a projected rotation velocity of v{sin}i=102.1+/- 1.3 {km} {{{s}}}-1. We measure the radius of the planet to be R=1.413+/- 0.054 {R}{{J}} and, based on RV observations, place a 95% confidence upper limit on its mass of M\\lt 1.85 {M}{{J}}. Based on theoretical stellar evolution models, the host star has a mass and radius of 1.47+/- 0.12 {M}⊙ and 1.500+/- 0.050 {R}⊙ , respectively. Spectroscopic observations made with Keck-I/HIRES during a partial transit event show the Doppler shadow of HAT-P-57b moving across the average spectral line profile of HAT-P-57, confirming the object as a planetary system. We use these observations, together with analytic formulae that we derive for the line profile distortions, to determine the projected angle between the spin axis of HAT-P-57 and the orbital axis of HAT-P-57b. The data permit two possible solutions, with -16\\buildrel{\\circ}\\over{.} 7\\lt λ \\lt 3\\buildrel{\\circ}\\over{.} 3 or 27\\buildrel{\\circ}\\over{.} 6\\lt λ \\lt 57\\buildrel{\\circ}\\over{.} 4 at 95% confidence, and with relative probabilities for the two modes of 26% and 74%, respectively. Adaptive optics imaging with MMT/Clio2 reveals an object located 2\\buildrel{\\prime\\prime}\\over{.} 7 from HAT-P-57 consisting of two point sources separated in turn from each other by 0\\buildrel{\\prime\\prime}\\over{.} 22. The H- and {L}\\prime -band magnitudes of the companion stars are consistent with their being physically associated with HAT-P-57, in which case they are stars of mass 0.61+/- 0.10 {M}⊙ and 0.53+/- 0.08 {M}⊙ . HAT-P-57 is the most rapidly rotating star, and only the fourth main sequence A star, known to host a transiting planet. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on observations made with the Keck-I telescope at Mauna

  11. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study.

    PubMed

    Do, Anh N; Irvin, Marguerite R; Lynch, Amy I; Claas, Steven A; Boerwinkle, Eric; Davis, Barry R; Ford, Charles E; Eckfeldt, John H; Tiwari, Hemant K; Limdi, Nita A; Arnett, Donna K

    2014-01-01

    Previous studies have reported that risk of cardiovascular morbidity and mortality substantially increases in hypertensive patients, especially among those with inadequate blood pressure control. Two common antihypertensive drug classes including thiazide diuretics and angiotensin-converting enzyme (ACE) inhibitors affect different enzymes in the renin-angiotensin-aldosterone system (RAAS). In the RAAS, angiotensinogen is converted into angiotensin II which increases blood pressure through vasoconstriction. Using a case-only design with 3448 high-risk hypertensive individuals from the Genetics of Hypertension Associated Treatment (GenHAT) study, we examined whether seven single nucleotide polymorphisms (SNPs) in the angiotensinogen gene (AGT) interact with three classes of antihypertensive drugs including chlorthalidone (a thiazide diuretic), lisinopril (an ACE inhibitor), and amlodipine (a calcium channel blocker) to modify the risk of incident coronary heart disease (CHD) and heart failure (HF) among Caucasian and African American participants, separately. We found no gene by treatment interactions to be statistically significant after correction for multiple testing. However, some suggestive results were found. African American participants with the minor allele of rs11122576 had over two-fold higher risk of CHD when using chlorthalidone compared to using amlodipine, or lisinopril compared to amlodipine (p = 0.006 and p = 0.01, respectively). Other marginal associations are also reported among both race groups. The findings reported here suggest that rs11122576 could contribute to future personalization of antihypertensive treatment among African Americans though more studies are needed.

  12. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study

    PubMed Central

    Do, Anh N.; Irvin, Marguerite R.; Lynch, Amy I.; Claas, Steven A.; Boerwinkle, Eric; Davis, Barry R.; Ford, Charles E.; Eckfeldt, John H.; Tiwari, Hemant K.; Limdi, Nita A.; Arnett, Donna K.

    2014-01-01

    Previous studies have reported that risk of cardiovascular morbidity and mortality substantially increases in hypertensive patients, especially among those with inadequate blood pressure control. Two common antihypertensive drug classes including thiazide diuretics and angiotensin-converting enzyme (ACE) inhibitors affect different enzymes in the renin-angiotensin-aldosterone system (RAAS). In the RAAS, angiotensinogen is converted into angiotensin II which increases blood pressure through vasoconstriction. Using a case-only design with 3448 high-risk hypertensive individuals from the Genetics of Hypertension Associated Treatment (GenHAT) study, we examined whether seven single nucleotide polymorphisms (SNPs) in the angiotensinogen gene (AGT) interact with three classes of antihypertensive drugs including chlorthalidone (a thiazide diuretic), lisinopril (an ACE inhibitor), and amlodipine (a calcium channel blocker) to modify the risk of incident coronary heart disease (CHD) and heart failure (HF) among Caucasian and African American participants, separately. We found no gene by treatment interactions to be statistically significant after correction for multiple testing. However, some suggestive results were found. African American participants with the minor allele of rs11122576 had over two-fold higher risk of CHD when using chlorthalidone compared to using amlodipine, or lisinopril compared to amlodipine (p = 0.006 and p = 0.01, respectively). Other marginal associations are also reported among both race groups. The findings reported here suggest that rs11122576 could contribute to future personalization of antihypertensive treatment among African Americans though more studies are needed. PMID:25278896

  13. A case study on a strong tropical disturbance and record heavy rainfall in Hat Yai, Thailand during the winter monsoon

    NASA Astrophysics Data System (ADS)

    Wangwongchai, Angkool; Zhao, Sixiong; Zeng, Qingcun

    2005-06-01

    The evolutionary process and structural characteristics of the atmospheric circulation and synoptic situation which caused the record heavy rainfall with a precipitation amount of 550 mm in Hat Yai, Thailand from 20 to 23 November 2000 is studied. In the study, the modern three dimensional observational data were collected as completely as possible, and detailed analyses were made. It is revealed that the cold surges of the Asian winter monsoon that originate from Siberia can arrive at the lower latitudes, including South Thailand, Malaysia, Indonesia, cause strong heavy rainfall there, and interact with weather systems in the near-equatorial regions of the Southern Hemisphere. This is strongly supported by Chinese scientist’s original finding in 1930s. The strong convective cloud clusters in the above areas are generated by the direct influence of the cold surges, and are related with the South China Sea disturbances in the lower troposphere. The maximum of the convergence of total moisture flux near South Thailand in the situation under study implies that the water vapour supply is abundant and very favorable to the occurrence of the heavy rainfall. The release of latent heat enhances the Hadley Circulation also. The feedback of the strong severe weather on climate indeed exists, and there are pronounced interactions between the multi-scale systems and between both hemispheres.

  14. Coupling quantum dots to optical fiber: Low pump threshold laser in the red with a near top hat beam profile

    SciTech Connect

    Cheng, H.; Mironov, A. E.; Ni, J. H.; Yang, H. J.; Chen, W. W.; Dai, Z.; Park, S.-J.; Eden, J. G.; Dragic, P. D.; Dong, J.

    2015-02-23

    Direct coupling of the optical field in a ∼244 nm thick, CdSe/ZnS quantum dot film to an optical fiber has yielded lasing in the red (λ ∼ 644 nm) with a threshold pump energy density < 2.6 mJ cm{sup −2}. Comprising 28–31 layers of ∼8 nm diameter quantum dots deposited onto the exterior surface of a 125 μm diameter coreless silica fiber, this free-running oscillator produces 134 nJ in 3.6 ns FWHM pulses which correspond to 37 W of peak power from an estimated gain volume of ∼4.5 × 10{sup −7} cm{sup 3}. Lasing was confirmed by narrowing of the output optical radiation in both the spectral and temporal domains, and the laser beam intensity profile approximates a top hat.

  15. Interaction with the histone chaperone Vps75 promotes nuclear localization and HAT activity of Rtt109 in vivo

    PubMed Central

    Keck, Kristin M.; Pemberton, Lucy F.

    2011-01-01

    Modification of histones is critical for the regulation of all chromatin-templated processes. Yeast Rtt109 is a histone acetyltransferase (HAT) that acetylates H3 lysines 9, 27 and 56. Rtt109 associates with and is stabilized by Nap1 family histone chaperone Vps75. Our data suggest Vps75 and Nap1 have some overlapping functions despite their different cellular localization and histone binding specificity. We determined that Vps75 contains a classical nuclear localization signal and is imported by Kap60–Kap95. Rtt109 nuclear localization depends on Vps75, and nuclear localization of the Vps75-Rtt109 complex is not critical for Rtt109-dependent functions, suggesting Rtt109 may be able to acetylate nascent histones before nuclear import. To date, the effects of VPS75 deletion on Rtt109 function had not been separated from the resulting Rtt109 degradation; thus, we used an Rtt109 mutant lacking the Vps75-interaction domain that is stable without Vps75. Our data show that in addition to promoting Rtt109 stability, Vps75 binding is necessary for Rtt109 acetylation of the H3 tail. Direct interaction of Vps75 with H3 likely allows Rtt109 access to the histone tail. Furthermore, our genetic interaction data support the idea of Rtt109-independent functions of Vps75. In summary, our data suggest that Vps75 influences chromatin structure by regulating histone modification and through its histone chaperone functions. PMID:21463458

  16. Single step synthesis of gold-amino acid composite, with the evidence of the catalytic hydrogen atom transfer (HAT) reaction, for the electrochemical recognition of Serotonin

    NASA Astrophysics Data System (ADS)

    Choudhary, Meenakshi; Siwal, Samarjeet; Nandi, Debkumar; Mallick, Kaushik

    2016-03-01

    A composite architecture of amino acid and gold nanoparticles has been synthesized using a generic route of 'in-situ polymerization and composite formation (IPCF)' [1,2]. The formation mechanism of the composite has been supported by a model hydrogen atom (H•≡H++e-) transfer (HAT) type of reaction which belongs to the proton coupled electron transfer (PCET) mechanism. The 'gold-amino acid composite' was used as a catalyst for the electrochemical recognition of Serotonin.

  17. HAT-P-24b: AN INFLATED HOT JUPITER ON A 3.36 DAY PERIOD TRANSITING A HOT, METAL-POOR STAR

    SciTech Connect

    Kipping, D. M.; Bakos, G. A.; Hartman, J.; Torres, G.; Latham, D. W.; Noyes, R. W.; Beky, B.; Perumpilly, G.; Esquerdo, G. A.; Sasselov, D. D.; Stefanik, R. P.; Shporer, A.; Kovacs, Geza; Howard, A. W.; Marcy, G. W.; Fischer, D. A.; Johnson, J. A.; Lazar, J.; Papp, I.; Sari, P.

    2010-12-20

    We report the discovery of HAT-P-24b, a transiting extrasolar planet orbiting the moderately bright V = 11.818 F8 dwarf star GSC 0774-01441, with a period P = 3.3552464 {+-} 0.0000071 days, transit epoch T{sub c} = 2455216.97669 {+-} 0.00024 (BJD)11, and transit duration 3.653 {+-} 0.025 hr. The host star has a mass of 1.191 {+-} 0.042 M{sub sun}, radius of 1.317 {+-} 0.068 R{sub sun}, effective temperature 6373 {+-} 80 K, and a low metallicity of [Fe/H] = -0.16 {+-} 0.08. The planetary companion has a mass of 0.681 {+-} 0.031 M{sub J} and radius of 1.243 {+-} 0.072 R{sub J} yielding a mean density of 0.439 {+-} 0.069 g cm{sup -3}. By repeating our global fits with different parameter sets, we have performed a critical investigation of the fitting techniques used for previous Hungarian-made Automated Telescope planetary discoveries. We find that the system properties are robust against the choice of priors. The effects of fixed versus fitted limb darkening are also examined. HAT-P-24b probably maintains a small eccentricity of e = 0.052{sup +0.022}{sub -0.017}, which is accepted over the circular orbit model with false alarm probability 5.8%. In the absence of eccentricity pumping, this result suggests that HAT-P-24b experiences less tidal dissipation than Jupiter. Due to relatively rapid stellar rotation, we estimate that HAT-P-24b should exhibit one of the largest known Rossiter-McLaughlin effect amplitudes for an exoplanet ({Delta}V{sub RM} {approx_equal} 95 m s{sup -1}) and thus a precise measurement of the sky-projected spin-orbit alignment should be possible.

  18. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix D. Final report

    SciTech Connect

    1988-07-01

    This appendix is an assessment of the present conditions of the inactive uranium mill site near Mexican Hat, Utah. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan. Plan is to characterize the conditions at the mill and tailings site so that the Remedial Action Contractor may complete final designs of the remedial action.

  19. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Text, Appendices A--C. Final report

    SciTech Connect

    1988-07-01

    This Remedial Action Plan (RAP) has been developed to serve a two- fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Appendices A,B, and C are provided as part of this document. Appendix A presents regulatory compliance issues, Appendix B provides details of the engineering design, and Appendix C presents the radiological support plan.

  20. Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).

    PubMed

    Carrillo, Angela K; Guiguemde, W Armand; Guy, R Kiplin

    2015-08-15

    Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma brucei brucei. Among the HDACi's, the hydroxamic acid derivatives panobinostat and belinostat exhibited potency that appeared to make them viable candidates for development due to their reported pharmacokinetic characteristics. However, cellular pharmacodynamic analysis demonstrated that these drugs were unable to kill cultured parasites at exposures seen in patients at their tolerated doses and additionally failed to show any synergistic effects in combination with pentamidine, suramin, melarsoprol, or nifurtimox. Analysis of the potency of the entire HDACi panel revealed no correlations between potency against any human HDAC isoform and inhibition of T. brucei proliferation, suggesting that the trypanosome histone deacetylases possess a unique specificity. These studies confirmed that HDAC inhibitors have potential as leads against human African trypanosomiasis but that none of the current clinical candidates can be directly repurposed. Therefore, development of HDACi's with appropriate specificity and potency may be a viable route to a new class of anti-trypanosomal drugs.

  1. Warm Spitzer and Palomar near-IR secondary eclipse photometry of two hot Jupiters: WASP-48b and HAT-P-23b

    SciTech Connect

    O'Rourke, Joseph G.; Knutson, Heather A.; Désert, Jean-Michel; Zhao, Ming; Fortney, Jonathan J.; Burrows, Adam; Agol, Eric; Deming, Drake; Howard, Andrew W.; Lewis, Nikole K.; Showman, Adam P.; Todorov, Kamen O.

    2014-02-01

    We report secondary eclipse photometry of two hot Jupiters, WASP-48b and HAT-P-23b, at 3.6 and 4.5 μm taken with the InfraRed Array Camera aboard the Spitzer Space Telescope during the warm Spitzer mission and in the H and K{sub S} bands with the Wide Field IR Camera at the Palomar 200 inch Hale Telescope. WASP-48b and HAT-P-23b are Jupiter-mass and twice Jupiter-mass objects orbiting an old, slightly evolved F star and an early G dwarf star, respectively. In the H, K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.047% ± 0.016%, 0.109% ± 0.027%, 0.176% ± 0.013%, and 0.214% ± 0.020% for WASP-48b. In the K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.234% ± 0.046%, 0.248% ± 0.019%, and 0.309% ± 0.026% for HAT-P-23b. For WASP-48b and HAT-P-23b, respectively, we measure delays of 2.6 ± 3.9 minutes and 4.0 ± 2.4 minutes relative to the predicted times of secondary eclipse for circular orbits, placing 2σ upper limits on |ecos ω| of 0.0053 and 0.0080, both of which are consistent with circular orbits. The dayside emission spectra of these planets are well-described by blackbodies with effective temperatures of 2158 ± 100 K (WASP-48b) and 2154 ± 90 K (HAT-P-23b), corresponding to moderate recirculation in the zero albedo case. Our measured eclipse depths are also consistent with one-dimensional radiative transfer models featuring varying degrees of recirculation and weak thermal inversions or no inversions at all. We discuss how the absence of strong temperature inversions on these planets may be related to the activity levels and metallicities of their host stars.

  2. Simplified Models for the Study of Postbuckled Hat-Stiffened Composite Panels

    NASA Technical Reports Server (NTRS)

    Vescovini, Riccardo; Davila, Carlos G.; Bisagni, Chiara

    2012-01-01

    The postbuckling response and failure of multistringer stiffened panels is analyzed using models with three levels of approximation. The first model uses a relatively coarse mesh to capture the global postbuckling response of a five-stringer panel. The second model can predict the nonlinear response as well as the debonding and crippling failure mechanisms in a single stringer compression specimen (SSCS). The third model consists of a simplified version of the SSCS that is designed to minimize the computational effort. The simplified model is well-suited to perform sensitivity analyses for studying the phenomena that lead to structural collapse. In particular, the simplified model is used to obtain a deeper understanding of the role played by geometric and material modeling parameters such as mesh size, inter-laminar strength, fracture toughness, and fracture mode mixity. Finally, a global/local damage analysis method is proposed in which a detailed local model is used to scan the global model to identify the locations that are most critical for damage tolerance.

  3. The rabbit in the hat: dubious argumentation and the persuasive effects of prescription drug advertising (DTCA).

    PubMed

    Rubinelli, Sara; Nakamoto, Kent; Schulz, Peter J

    2008-01-01

    There is an ongoing global debate over the potential benefits and risks of allowing direct-to-consumer advertising of prescription medicines (DTCA). The core of this debate concerns the identification of DTCA either as a beneficial procedure to be promoted or as a damaging procedure to be abolished. Economic data on DTCA suggest that this form of advertising has an impact on consumers. Based on this premise, we explore the use of argumentation theory to inquire into the reasons for this success. In particular, by combining perspectives from argumentation theory and marketing research this paper aims to test the hypothesis of whether DTCA presents information framed in potentially misleading, but persuasive, argumentative structures. We highlight and discuss the results of two studies designed to assess whether readers perceive DTCA as argumentative and, if so, which explicit and implicit elements provide groundings for the inference that consumers draw from the ads. The analysis highlights the presence in DTCA of dubious arguments (fallacies and distracting claims) that may go unnoticed. Also, it illustrates the nature of readers' wrong assumptions that arise independently from the contents of the ads. These factors seem to influence the level of the self-perceived persuasiveness of DTCA.

  4. Transmission spectroscopy of HAT-P-32b with the LBT: confirmation of clouds/hazes in the planetary atmosphere

    NASA Astrophysics Data System (ADS)

    Mallonn, M.; Strassmeier, K. G.

    2016-05-01

    Aims: Spectroscopic observations of a transit event of an extrasolar planet offer the opportunity to study the composition of the planetary atmosphere. This can be done with comparably little telescope time using a low-resolution multi-object spectrograph at a large aperture telescope. We observed a transit of the inflated hot Jupiter HAT-P-32b with the Multi-Object Double Spectrograph at the Large Binocular Telescope to characterize its atmosphere from 3300 to 10 000 Å. Methods: A time series of target and reference star spectra was binned in two broad-band wavelength channels, from which differential transit light curves were constructed. These broad-band light curves were used to confirm previous transit parameter determinations. To derive the planetary transmission spectrum with a resolution of R ~ 60, we created a chromatic set of 62 narrow-band light curves. The spectrum was corrected for the third light of a nearby M star. Additionally, we undertook a photometric monitoring campaign of the host star to correct for the influence of starspots. Results: The transmission spectrum of HAT-P-32b shows no pressure-broadened absorption features from Na and K, which is interpreted by the presence of clouds or hazes in the planetary atmosphere. This result is in agreement with previous studies on the same planet. The presence of TiO in gas phase could be ruled out. We find a 2.8σ indication of increased absorption in the line core of potassium (K I 7699 Å). No narrow absorption features of Na and Hα were detected. Furthermore, tentative indications were found for a slope of increasing opacity toward blue wavelengths from the near-IR to the near-UV with an amplitude of two scale heights. If confirmed by follow-up observations, it can be explained by aerosols either causing Mie scattering or causing Rayleigh scattering with an aerosol - gas scale height ratio below unity. The host star was found to be photometrically stable within the measurement precision. Based on

  5. THE STELLAR OBLIQUITY AND THE LONG-PERIOD PLANET IN THE HAT-P-17 EXOPLANETARY SYSTEM

    SciTech Connect

    Fulton, Benjamin J.; Howard, Andrew W.; Winn, Joshua N.; Albrecht, Simon; Marcy, Geoffrey W.; Isaacson, Howard; Crepp, Justin R.; Bakos, Gaspar A.; Hartman, Joel D.; Johnson, John Asher; Knutson, Heather A.; Zhao Ming

    2013-08-01

    We present the measured projected obliquity-the sky-projected angle between the stellar spin axis and orbital angular momentum-of the inner planet of the HAT-P-17 multi-planet system. We measure the sky-projected obliquity of the star to be {lambda}=19{sup +14}{sub -16} deg by modeling the Rossiter-McLaughlin effect in Keck/HIRES radial velocities (RVs). The anomalous RV time series shows an asymmetry relative to the midtransit time, ordinarily suggesting a nonzero obliquity-but in this case at least part of the asymmetry may be due to the convective blueshift, increasing the uncertainty in the determination of {lambda}. We employ the semi-analytical approach of Hirano et al. that includes the effects of macroturbulence, instrumental broadening, and convective blueshift to accurately model the anomaly in the net RV caused by the planet eclipsing part of the rotating star. Obliquity measurements are an important tool for testing theories of planet formation and migration. To date, the measured obliquities of {approx}50 Jovian planets span the full range, from prograde to retrograde, with planets orbiting cool stars preferentially showing alignment of stellar spins and planetary orbits. Our results are consistent with this pattern emerging from tidal interactions in the convective envelopes of cool stars and close-in planets. In addition, our 1.8 yr of new RVs for this system show that the orbit of the outer planet is more poorly constrained than previously thought, with an orbital period now in the range of 10-36 yr.

  6. VizieR Online Data Catalog: Hat Creek High-Latitude H I Survey (Heiles+ 1974-1976)

    NASA Astrophysics Data System (ADS)

    Heiles, C.; Habing, H. J.

    1997-03-01

    This survey consists of H I 21-cm spectra covering the entire northern sky with absolute Galactic latitude |b|>10 degrees and declination dec>-30degrees. The observations were made with the Hat Creek 85-foot telescope between 1968 and 1970. The individual spectra were obtained with a bank of 100 filters covering the velocity range from -92km/s to +75km/s. The velocity resolution was 2 km/sec (except at the ends of the spectra) and the beamwidth was 36arcmin. The spacing between points observed on the sky is (0.3deg/cosb) in Galactic longitude and (0.6deg) in Galactic latitude. A FITS version of the survey was derived at the Astrophysics Data Facility (NASA/GSFC) from the original catalog of spectra. The approximately 130,000 good spectra in the catalog (i.e., those with status code 1 and which have flat baselines) were interpolated to a uniform channel width in frequency, shifted as appropriate to take into account the proper central velocities, then interpolated onto a regular grid in Galactic coordinates. For the latter interpolation, the cos(b) corrections for longitude offsets were taken into account; no interpolation was done across gaps in coverage greater than 2 deg. Latitude-velocity slices were written in FITS format for each 30 arcmin of longitude. Separate files were written for the negative latitude (b < -10 deg ) and positive latitude (b > 10 deg) ranges. Slices containing no spectra, primarily negative latitude spectra in the fourth Galactic quadrant, were not written. A longitude-latitude map, integrated over all velocities, was also written in FITS format to illustrate the coverage of the individual latitude-velocity slices. (2 data files).

  7. Wave-turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential

    NASA Astrophysics Data System (ADS)

    Gallet, Basile; Nazarenko, Sergey; Dubrulle, Bérengère

    2015-07-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models, one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wave number, whereas the latter obey an acoustic dispersion relation. Using wave-turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bose-Einstein condensation. We then focus on nonlocal interactions in wave-number space: we study the decay of an ensemble of massive particles into massless ones. Under rather general conditions, these massless particles accumulate at low wave number. We study the dynamics of waves coexisting with such a strong condensate, and we compute rigorously a nonlocal Kolmogorov-Zakharov solution, where particles are transferred nonlocally to the condensate, while energy cascades towards large wave numbers through local interactions. This nonlocal cascading state constitutes the intermediate asymptotics between the initial distribution of waves and the thermodynamic state reached in the long-time limit.

  8. Wave-turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential.

    PubMed

    Gallet, Basile; Nazarenko, Sergey; Dubrulle, Bérengère

    2015-07-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models, one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wave number, whereas the latter obey an acoustic dispersion relation. Using wave-turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bose-Einstein condensation. We then focus on nonlocal interactions in wave-number space: we study the decay of an ensemble of massive particles into massless ones. Under rather general conditions, these massless particles accumulate at low wave number. We study the dynamics of waves coexisting with such a strong condensate, and we compute rigorously a nonlocal Kolmogorov-Zakharov solution, where particles are transferred nonlocally to the condensate, while energy cascades towards large wave numbers through local interactions. This nonlocal cascading state constitutes the intermediate asymptotics between the initial distribution of waves and the thermodynamic state reached in the long-time limit.

  9. HAT DRMs 2013

    NASA Technical Reports Server (NTRS)

    Drake, Bret G.

    2013-01-01

    NASA uses a set of Design Reference Missions (DRMs) to help focus capability development activities across the agency The DRMs are intended to show capability needs and represent a set of various implementations The "mission class" context is used to establish temporal priorities and a LIMITED set of DRMs is used to capture driving mission capabilities The DRMs represent a snapshot in time of current thinking, and do not represent all potential future missions The DRMs are generic in nature, with stated assumptions for some supporting capabilities and elements - they do not represent firm requirements SLS/Orion DRMs are being developed and refined as part of the development program for SLS & Orion and are not included in this package.

  10. New year, old hat

    NASA Astrophysics Data System (ADS)

    American Geological Institute; American Institute of Physics; American Associationthe Advancement of Science; Carlowicz, Michael

    It is only August, but October 1 looms large on the calendar. That is the day when the 1997 fiscal year (FY ‧97) begins for the U.S. federal government, and like last year, that day might come without a budget.In a flurry of summer activity, the U.S. Congress has passed several landmark bills on welfare reform, expansion of health coverage for workers between jobs, a raise in the minimum wage, and a Safe Drinking Water Act. The House of Representatives even passed all 13 of its annual appropriations bills before Congress took its August recess.

  11. Hats off to Science

    ERIC Educational Resources Information Center

    Jackson, Julie K.; Newell, Nancy

    2012-01-01

    Words are the foundation of knowledge. They are powerful tools used to express ideas, communicate with others, access knowledge, and learn about new concepts. Research shows a strong relationship between student word knowledge and academic achievement. As a result, building academic content vocabulary is an important part of science instruction.…

  12. Danger: Falling Hats

    ERIC Educational Resources Information Center

    Troop, Don

    2009-01-01

    Tossing mortarboards at commencement is all fun and games until somebody gets her head sliced open. This article describes the harrowing experiences of Trudy Kuehner, a graduating senior at Sterling Regional High School 31 years ago, and another 17-year-old graduate who were both injured by a mortarboard. Such injuries are the exception, though,…

  13. HAT-P-12b: A LOW-DENSITY SUB-SATURN MASS PLANET TRANSITING A METAL-POOR K DWARF

    SciTech Connect

    Hartman, J. D.; Bakos, G. A.; Torres, G.; Noyes, R. W.; Pal, A.; Latham, D. W.; Sipocz, B.; Esquerdo, G. A.; Sasselov, D. D.; Kovacs, Gabor; Stefanik, R. P.; Fernandez, J. M.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Marcy, G. W.; Howard, A. W.; Butler, R. P.; Lazar, J.; Papp, I.

    2009-11-20

    We report on the discovery of HAT-P-12b, a transiting extrasolar planet orbiting the moderately bright V approx 12.8 K4 dwarf GSC 03033 - 00706, with a period P = 3.2130598 +- 0.0000021 d, transit epoch T{sub c} = 2454419.19556 +- 0.00020 (BJD), and transit duration 0.0974 +- 0.0006 d. The host star has a mass of 0.73 +- 0.02 M{sub sun}, radius of 0.70{sup +0.02}{sub -0.01} R{sub sun}, effective temperature 4650 +- 60 K, and metallicity [Fe/H] = -0.29 +- 0.05. We find a slight correlation between the observed spectral line bisector spans and the radial velocity, so we consider, and rule out, various blend configurations including a blend with a background eclipsing binary, and hierarchical triple systems where the eclipsing body is a star or a planet. We conclude that a model consisting of a single star with a transiting planet best fits the observations, and show that a likely explanation for the apparent correlation is contamination from scattered moonlight. Based on this model, the planetary companion has a mass of 0.211 +- 0.012 M{sub J} and radius of 0.959{sup +0.029}{sub -0.021} R{sub J} yielding a mean density of 0.295 +- 0.025 g cm{sup -3}. Comparing these observations with recent theoretical models, we find that HAT-P-12b is consistent with a approx1-4.5 Gyr, mildly irradiated, H/He-dominated planet with a core mass M{sub C} approx< 10 M {sub +}. HAT-P-12b is thus the least massive H/He-dominated gas giant planet found to date. This record was previously held by Saturn.

  14. HAT-P-56b: An Inflated Massive Hot Jupiter Transiting a Bright F Star Followed Up with K2 Campaign 0 Observations

    NASA Astrophysics Data System (ADS)

    Huang, C. X.; Hartman, J. D.; Bakos, G. Á.; Penev, K.; Bhatti, W.; Bieryla, A.; de Val-Borro, M.; Latham, D. W.; Buchhave, L. A.; Csubry, Z.; Kovács, G.; Béky, B.; Falco, E.; Berlind, P.; Calkins, M. L.; Esquerdo, G. A.; Lázár, J.; Papp, I.; Sári, P.

    2015-09-01

    We report the discovery of HAT-P-56b by the HATNet survey, an inflated hot Jupiter transiting a bright F-type star in Field 0 of NASA's K2 mission. We combine ground-based discovery and follow-up light curves with high precision photometry from K2, as well as ground-based radial velocities from the Tillinghast Reflector Echelle Spectrograph on the Fred Lawrence Whipple Observatory 1.5 m telescope to determine the physical properties of this system. HAT-P-56b has a mass of 2.18 {M}{{J}}, radius of 1.47 {R}{{J}}, and transits its host star on a near-grazing orbit with a period of 2.7908 day. The radius of HAT-P-56b is among the largest known for a planet with {M}p\\gt 2 {M}{{J}}. The host star has a V-band magnitude of 10.9, mass of 1.30 {M}⊙ , and radius of 1.43 {R}⊙ . The periodogram of the K2 light curve suggests that the star is a γ Dor variable. HAT-P-56b is an example of a ground-based discovery of a transiting planet, where space-based observations greatly improve the confidence in the confirmation of its planetary nature, and also improve the accuracy of the planetary parameters. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on observations obtained with the Tillinghast Reflector 1.5 m telescope and the 1.2 m telescope, both operated by the Smithsonian Astrophysical Observatory at the Fred Lawrence Whipple Observatory in Arizona. Based in part on observations obtained with the Apache Point Observatory 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium. Based in part on observations obtained with the Kepler Space Craft in the K2 Campaign 0 Mission.

  15. Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs

    PubMed Central

    Taverna, Sean D.; Ilin, Serge; Rogers, Richard S.; Tanny, Jason C.; Lavender, Heather; Li, Haitao; Baker, Lindsey; Boyle, John; Blair, Lauren P.; Chait, Brian T.; Patel, Dinshaw J.; Aitchison, John D.; Tackett, Alan J.; Allis, C. David

    2015-01-01

    Summary Posttranslational histone modifications participate in modulating the structure and function of chromatin. Promoters of transcribed genes are enriched with K4 trimethylation and hyperacetylation on the N-terminal tail of histone H3. Recently, PHD finger proteins, like Yng1 in the NuA3 HAT complex, were shown to interact with H3K4me3, indicating a biochemical link between K4 methylation and hyperacetylation. By using a combination of mass spectrometry, biochemistry, and NMR, we detail the Yng1 PHD-H3K4me3 interaction and the importance of NuA3-dependent acetylation at K14. Furthermore, genome-wide ChIP-Chip analysis demonstrates colocalization of Yng1 and H3K4me3 in vivo. Disrupting the K4me3 binding of Yng1 altered K14ac and transcription at certain genes, thereby demonstrating direct in vivo evidence of sequential trimethyl binding, acetyltransferase activity, and gene regulation by NuA3. Our data support a general mechanism of transcriptional control through which histone acetylation upstream of gene activation is promoted partially through availability of H3K4me3, “read” by binding modules in select subunits. PMID:17157260

  16. Modeling the response of a top hat electrostatic analyzer in an external magnetic field: Experimental validation with the Juno JADE-E sensor

    NASA Astrophysics Data System (ADS)

    Clark, G.; Allegrini, F.; McComas, D. J.; Louarn, P.

    2016-06-01

    We investigate the response function of an electrostatic analyzer when electron gyroradii in a magnetic field become comparable to the scale size of the sensor. This occurs when electrons have sufficiently small energies and are in a strong magnetic field. Through simulations and laboratory experiments with the Jovian Auroral Distribution Experiment-Electron (JADE-E) sensor, we observe the energy response, detection angle distribution, and geometric factor to change significantly. Using electro-optics simulation results, we develop semiempirical and empirical relationships that can be used for top hat electrostatic analyzers. We present a model based on these relationships that covers an energy range between 0.1 keV and 5 keV with a uniform external magnetic field magnitude between 0-3 G and verified that these relationships apply to JADE-E in a specially designed testing environment by comparing with the model. We find that the model agrees well with the JADE-E sensor validating it for top hat electrostatic analyzers more generally.

  17. HAT-P-49b: a 1.7 M {sub J} planet transiting a bright 1.5 M {sub ☉} F-star

    SciTech Connect

    Bieryla, A.; Latham, D. W.; Buchhave, L. A.; Béky, B.; Falco, E.; Torres, G.; Noyes, R. W.; Berlind, P.; Calkins, M. C.; Esquerdo, G. A.; Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Csubry, Z.; Penev, K.; De Val-Borro, M.; Kovács, G.; Boisse, I.; Lázár, J.; Papp, I. E-mail: gbakos@astro.princeton.edu; and others

    2014-04-01

    We report the discovery of the transiting extrasolar planet HAT-P-49b. The planet transits the bright (V = 10.3) slightly evolved F-star HD 340099 with a mass of 1.54 M {sub ☉} and a radius of 1.83 R {sub ☉}. HAT-P-49b is orbiting one of the 25 brightest stars to host a transiting planet which makes this a favorable candidate for detailed follow-up. This system is an especially strong target for Rossiter-McLaughlin follow-up due to the host star's fast rotation, 16 km s{sup –1}. The planetary companion has a period of 2.6915 days, mass of 1.73 M {sub J}, and radius of 1.41 R {sub J}. The planetary characteristics are consistent with that of a classical hot Jupiter but we note that this is the fourth most massive star to host a transiting planet with both M{sub p} and R{sub p} well determined.

  18. Text-based over-representation analysis of microarray gene lists with annotation bias

    PubMed Central

    Leong, Hui Sun; Kipling, David

    2009-01-01

    A major challenge in microarray data analysis is the functional interpretation of gene lists. A common approach to address this is over-representation analysis (ORA), which uses the hypergeometric test (or its variants) to evaluate whether a particular functionally defined group of genes is represented more than expected by chance within a gene list. Existing applications of ORA have been largely limited to pre-defined terminologies such as GO and KEGG. We report our explorations of whether ORA can be applied to a wider mining of free-text. We found that a hitherto underappreciated feature of experimentally derived gene lists is that the constituents have substantially more annotation associated with them, as they have been researched upon for a longer period of time. This bias, a result of patterns of research activity within the biomedical community, is a major problem for classical hypergeometric test-based ORA approaches, which cannot account for such bias. We have therefore developed three approaches to overcome this bias, and demonstrate their usability in a wide range of published datasets covering different species. A comparison with existing tools that use GO terms suggests that mining PubMed abstracts can reveal additional biological insight that may not be possible by mining pre-defined ontologies alone. PMID:19429895

  19. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  20. The University of Arizona Astronomy Club Follow-up Observations of Transiting Extra-solar Planet HAT-P-36b

    NASA Astrophysics Data System (ADS)

    Thompson, Robert; Turner, J.; Jones, C.; Pearson, K.; Biddle, L. I.; Berube, M.

    2013-06-01

    We observed 5 primary transits of exoplanet HAT-P-36b with the Steward Observatory 1.55 meter Kuiper Telescope in the U and R photometric bands. With our results, we have been able to produce a more complete light curve and refine previously published values for the planet’s mass, radius, density, surface gravity, Safronov number, equilibrium temperature, orbital distance, orbital inclination. We developed a modeling package that uses the Levenberg-Marquardt minimization algorithm to find the least-squares best fit to the light curve. The errors were generated using a bootstrap Monte Carlo method. The red noise of the transit was determined by using the permutation “rosary bead” method, which constrains the red noise in our transits better than the publicly available modeling package, TAP.

  1. A study of the prevalence of and risk factors for ear diseases and hearing loss in primary school children in Hat Yai, Thailand.

    PubMed

    Chayarpham, S; Stuart, J; Chongsuvivatwong, V; Chinpairoj, S; Lim, A

    1996-07-01

    2,184 primary school children in Hat Yai Municipality, Southern Thailand were screened for ear diseases and hearing loss using screening audiometry, portable tympanometry and otoscopy to identify children with possible ear problems, 754 children failed the initial screen, 728 were retested and a group of 243 were referred for ENT examination and standard audiometry-tympanometry. Children with hearing loss and otitis media were thus identified. A questionnaire to identify possible risk factors was administered. The prevalence of otitis media in this population was found to be 3.25 per cent (AOM 0.69%, OME 1.14%, COM 1.74%). No risk factor identified as significant were found. Non-significant factors included sex, age, URI last month, father smoking, mother smoking and method of transport to school as an indication of social status. This study contrasts with a previous study in 1990 which showed a 3.5 per cent prevalence of COM.

  2. Modification to the Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Volume 1, Text, Attachments 1--6. Final report

    SciTech Connect

    1989-01-01

    This document provides the modifications to the 1988 Remedial Action Plan (RAP) of the contaminated materials at the Monument Valley, Arizona, and Mexican Hat, Utah. The text detailing the modifications and attachments 1 through 6 are provided with this document. The RAP was developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents.

  3. The Effectiveness of Training Program Based on the Six Hats Model in Developing Creative Thinking Skills and Academic Achievements in the Arabic Language Course for Gifted and Talented Jordanian Students

    ERIC Educational Resources Information Center

    Ziadat, Ayed H.; Al Ziyadat, Mohammad T.

    2016-01-01

    The main purpose of this study was to determine the effectiveness of a training program based on the six hats model in developing creative thinking skills and academic achievements in the Arabic language for gifted and talented Jordanian students. The study sample consisted of 59 gifted male and female students of the 7th grade from King Abdullah…

  4. HATS-6b: A Warm Saturn Transiting an Early M Dwarf Star, and a Set of Empirical Relations for Characterizing K and M Dwarf Planet Hosts

    NASA Astrophysics Data System (ADS)

    Hartman, J. D.; Bayliss, D.; Brahm, R.; Bakos, G. Á.; Mancini, L.; Jordán, A.; Penev, K.; Rabus, M.; Zhou, G.; Butler, R. P.; Espinoza, N.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Ciceri, S.; Henning, T.; Schmidt, B.; Arriagada, P.; Shectman, S.; Crane, J.; Thompson, I.; Suc, V.; Csák, B.; Tan, T. G.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2015-05-01

    We report the discovery by the HATSouth survey of HATS-6b, an extrasolar planet transiting a V = 15.2 mag, i = 13.7 mag M1V star with a mass of 0.57 {{M}⊙ } and a radius of 0.57 {{R}⊙ }. HATS-6b has a period of P = 3.3253 d, mass of {{M}p} = 0.32 {{M}J}, radius of {{R}p} = 1.00 {{R}J}, and zero-albedo equilibrium temperature of {{T}eq} = 712.8 ± 5.1 K. HATS-6 is one of the lowest mass stars known to host a close-in gas giant planet, and its transits are among the deepest of any known transiting planet system. We discuss the follow-up opportunities afforded by this system, noting that despite the faintness of the host star, it is expected to have the highest K-band S/N transmission spectrum among known gas giant planets with {{T}eq}\\lt 750 K. In order to characterize the star we present a new set of empirical relations between the density, radius, mass, bolometric magnitude, and V-, J-, H- and K-band bolometric corrections for main sequence stars with M\\lt 0.80 {{M}⊙ }, or spectral types later than K5. These relations are calibrated using eclipsing binary components as well as members of resolved binary systems. We account for intrinsic scatter in the relations in a self-consistent manner. We show that from the transit-based stellar density alone it is possible to measure the mass and radius of a ˜0.6 {{M}⊙ } star to ˜7 and ˜2% precision, respectively. Incorporating additional information, such as the V-K color, or an absolute magnitude, allows the precision to be improved by up to a factor of two. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA

  5. Uncertainties of the Gravity Recovery and Climate Experiment time-variable gravity-field solutions based on three-cornered hat method

    NASA Astrophysics Data System (ADS)

    Ferreira, Vagner G.; Montecino, Henry D. C.; Yakubu, Caleb I.; Heck, Bernhard

    2016-01-01

    Currently, various satellite processing centers produce extensive data, with different solutions of the same field being available. For instance, the Gravity Recovery and Climate Experiment (GRACE) has been monitoring terrestrial water storage (TWS) since April 2002, while the Center for Space Research (CSR), the Jet Propulsion Laboratory (JPL), the GeoForschungsZentrum (GFZ), and the Groupe de Recherche de Géodésie Spatiale (GRGS) provide individual monthly solutions in the form of Stokes coefficients. The inverted TWS maps (or the regionally averaged values) from these coefficients are being used in many applications; however, as no ground truth data exist, the uncertainties are unknown. Consequently, the purpose of this work is to assess the quality of each processing center by estimating their uncertainties using a generalized formulation of the three-cornered hat (TCH) method. Overall, the TCH results for the study period of August 2002 to June 2014 indicate that at a global scale, the CSR, GFZ, GRGS, and JPL presented uncertainties of 9.4, 13.7, 14.8, and 13.2 mm, respectively. At a basin scale, the overall good performance of the CSR was observed at 91 river basins. The TCH-based results were confirmed by a comparison with an ensemble solution from the four GRACE processing centers.

  6. Uncertainties of the Gravity Recovery and Climate Experiment time-variable gravity-field solutions based on three-cornered hat method

    NASA Astrophysics Data System (ADS)

    Ferreira, Vagner G.; Montecino, Henry D. C.; Yakubu, Caleb I.; Heck, Bernhard

    2016-01-01

    Currently, various satellite processing centers produce extensive data, with different solutions of the same field being available. For instance, the Gravity Recovery and Climate Experiment (GRACE) has been monitoring terrestrial water storage (TWS) since April 2002, while the Center for Space Research (CSR), the Jet Propulsion Laboratory (JPL), the GeoForschungsZentrum (GFZ), and the Groupe de Recherche de Géodésie Spatiale (GRGS) provide individual monthly solutions in the form of Stokes coefficients. The inverted TWS maps (or the regionally averaged values) from these coefficients are being used in many applications; however, as no ground truth data exist, the uncertainties are unknown. Consequently, the purpose of this work is to assess the quality of each processing center by estimating their uncertainties using a generalized formulation of the three-cornered hat (TCH) method. Overall, the TCH results for the study period of August 2002 to June 2014 indicate that at a global scale, the CSR, GFZ, GRGS, and JPL presented uncertainties of 9.4, 13.7, 14.8, and 13.2 mm, respectively. At a basin scale, the overall good performance of the CSR was observed at 91 river basins. The TCH-based results were confirmed by a comparison with an ensemble solution from the four GRACE processing centers.

  7. Determining the coordinate dependence of some components of the cubic susceptibility tensor {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}) of a one-dimensionally inhomogeneous absorbing plate at an arbitrary frequency dispersion

    SciTech Connect

    Golubkov, A A; Makarov, Vladimir A

    2010-12-29

    The possibility of unique reconstruction of the spatial profile of the cubic nonlinear susceptibility tensor component {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}) of a one-dimensionally inhomogeneous plate whose medium has a symmetry plane m{sub y} perpendicular to its surface is proved for the first time and the unique reconstruction algorithm is proposed. The amplitude complex coefficients of reflection and transmission (measured in some range of angles of incidence) as well as of conversion of an s-polarised plane signal monochromatic wave into two waves propagating on both sides of the plate make it possible to reconstruct the profile. These two waves result from nonlinear interaction of a signal wave with an intense plane wave incident normally on the plate. All the waves under consideration have the same frequency {omega}, and so its variation helps study the frequency dispersion of the cubic nonlinear susceptibility tensor component {chi}-hat{sub yyyy}{sup (3)}(z, {omega}, -{omega}, {omega}, {omega}). For media with additional symmetry axes 2{sub z}, 4{sub z}, 6{sub z}, or {infinity}{sub z} that are perpendicular to the plate surface, the proposed method can be used to reconstruct the profile and to examine the frequency dispersion of about one third of all independent complex components of the tensor {chi}-hat{sup (3)}. (nonlinear-optics phenomena)

  8. Two dimensional symmetric correlation functions of the {hat S} operator and two dimensional Fourier transforms: Considering the line coupling for P and R lines of linear molecules

    NASA Astrophysics Data System (ADS)

    Ma, Q.; Boulet, C.; Tipping, R. H.

    2014-03-01

    The refinement of the Robert-Bonamy (RB) formalism by considering the line coupling for isotropic Raman Q lines of linear molecules developed in our previous study [Q. Ma, C. Boulet, and R. H. Tipping, J. Chem. Phys. 139, 034305 (2013)] has been extended to infrared P and R lines. In these calculations, the main task is to derive diagonal and off-diagonal matrix elements of the Liouville operator iS1 - S2 introduced in the formalism. When one considers the line coupling for isotropic Raman Q lines where their initial and final rotational quantum numbers are identical, the derivations of off-diagonal elements do not require extra correlation functions of the {hat S} operator and their Fourier transforms except for those used in deriving diagonal elements. In contrast, the derivations for infrared P and R lines become more difficult because they require a lot of new correlation functions and their Fourier transforms. By introducing two dimensional correlation functions labeled by two tensor ranks and making variable changes to become even functions, the derivations only require the latters' two dimensional Fourier transforms evaluated at two modulation frequencies characterizing the averaged energy gap and the frequency detuning between the two coupled transitions. With the coordinate representation, it is easy to accurately derive these two dimensional correlation functions. Meanwhile, by using the sampling theory one is able to effectively evaluate their two dimensional Fourier transforms. Thus, the obstacles in considering the line coupling for P and R lines have been overcome. Numerical calculations have been carried out for the half-widths of both the isotropic Raman Q lines and the infrared P and R lines of C2H2 broadened by N2. In comparison with values derived from the RB formalism, new calculated values are significantly reduced and become closer to measurements.

  9. Levels of Cholesterol in Small LDL Particles Predict Atherosclerosis Progression and Incident CHD in the HDL-Atherosclerosis Treatment Study (HATS)

    PubMed Central

    Williams, Paul T.; Zhao, Xue-Qiao; Marcovina, Santica M.; Brown, B. Greg; Krauss, Ronald M.

    2013-01-01

    Objective Test whether angiographically-documented changes in percent stenosis and clinical endpoints (coronary-related deaths, myocardial infarctions, stroke, revascularization for worsening ischemia) in the HDL-Atherosclerosis Treatment Study (HATS) were attributable to specific LDL-subclasses. Methods Gradient gel electrophoresis of on-study LDL-subclass cholesterol concentrations were measured in 32 placebo, 33 simvastatin-niacin, 38 antioxidant, and 39 simvastatin-niacin & antioxidant treated participants. The prespecified primary end point was the mean change per patient from the initial arteriogram to the final arteriogram in the percent stenosis caused by the most severe lesion in each of the nine proximal coronary segments. Results The change in the percent stenosis of the most severe proximal lesions increased in association with higher concentrations of the small LDL subfractions LDL-IIIb (24.2–24.6 nm) and LDL-IVa (23.3–24.1 nm) before (both P = 0.002) and after (P = 0.01 and P = 0.03 respectively) adjustment for treatment group and on-study HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations. The associations appeared specific to lesions with <30% baseline stenosis. When adjusted for age, sex, baseline BMI and cigarette use, the odds for primary clinical endpoints (death from coronary causes, nonfatal myocardial infarction, stroke, or revascularization for worsening ischemia) were significantly greater in subjects with higher on-study LDL-IIIb levels both before (P = 0.01) and after (P = 0.03) adjustment for treatment group and the standard lipid values. Conclusions Plasma LDL-IIIb cholesterol concentrations were related to changes in coronary artery stenosis and cardiovascular events in patients with coronary artery disease and low HDL-cholesterol. Trial Registration ClinicalTrials.gov NCT00000553 PMID:23460815

  10. The optical transmission spectrum of the hot Jupiter HAT-P-32b: clouds explain the absence of broad spectral features?

    NASA Astrophysics Data System (ADS)

    Gibson, N. P.; Aigrain, S.; Barstow, J. K.; Evans, T. M.; Fletcher, L. N.; Irwin, P. G. J.

    2013-12-01

    We report Gemini-North Gemini Multi-Object Spectrograph observations of the inflated hot Jupiter HAT-P-32b during two primary transits. We simultaneously observed two comparison stars and used differential spectrophotometry to produce multiwavelength light curves. `White' light curves and 29 `spectral' light curves were extracted for each transit and analysed to refine the system parameters and produce transmission spectra from 520 to 930 nm in ≈14 nm bins. The light curves contain time-varying white noise as well as time-correlated noise, and we used a Gaussian process model to fit this complex noise model. Common mode corrections derived from the white light-curve fits were applied to the spectral light curves which significantly improved our precision, reaching typical uncertainties in the transit depth of ˜2 × 10-4, corresponding to about half a pressure scale height. The low-resolution transmission spectra are consistent with a featureless model, and we can confidently rule out broad features larger than about one scale height. The absence of Na/K wings or prominent TiO/VO features is most easily explained by grey absorption from clouds in the upper atmosphere, masking the spectral features. However, we cannot confidently rule out clear atmosphere models with low abundances (˜10-3 solar) of TiO, VO or even metal hydrides masking the Na and K wings. A smaller scale height or ionization could also contribute to muted spectral features, but alone are unable to account for the absence of features reported here.

  11. IMMUNO-MAGNETIC ISOLATION, CHARACTERIZATION AND GENETIC RELATIONSHIP OF ESCHERICHIA COLI O26 FROM RAW MEATS, HAT YAI CITY, SONGKHLA, THAILAND.

    PubMed

    Siriwan-Sirikaew; Rattanachuay, Pattamarat; Nakaguchi, Yoshitsugu; Sukhumungoonl, Pharanai

    2015-03-01

    Escherichia coli O26 is the most important serotype in non-O157 group, which plays a significant role in gastrointestinal illnesses. However, information regarding the prevalence and its characteristics are lacking in Thailand. As raw meat is frequently a source of diarrheagenic E. coli, a total of 1,279 E. coli colonies were obtained from 157 raw meat samples obtained from retail markets in Hat Yai City, Songkhla Province, Thailand and E. coli O26 isolated using an immunemagnetic separation technique. Twenty-seven E. coli O26 strains were isolated from 18 samples of raw beef, chicken and pork meats. These E. coli O26 strains could not be classified into the six diarrheagenic E. coli categories and did not harbor virulence genes, except 5 strains carrying escV, encoding type III secretion system component. Phylogenetic group examination demonstrated that 26 strains belonged to phylogenetic group A, and one to group D. Antimicrobial susceptibility test revealed that the E. coli O26 strains were the multi-drug resistant strains. Genetic relatedness employing (GTG)5-PCR and ERIC2-PCR showed that some of O26 which isolated from different samples and different time intervals revealed the identical fingerprint pattern, suggesting that they were derived from the same clone. Examination of five stx2-containing phage integration sites showed that 6 strains had prophage occupancy at sbcB, suggesting that these isolates have the potential in horizontal gene transfer of virulence trait. Moreover, the intactness of yecE and wrbA, the important integration sites in E. coli O26, indicated the possibility of stx2-phage lysogenization in the future. PMID:26513927

  12. Morphological analysis of infrared images for waterjets

    NASA Astrophysics Data System (ADS)

    Gong, Yuxin; Long, Aifang

    2013-03-01

    High-speed waterjet has been widely used in industries and been investigated as a model of free shearing turbulence. This paper presents an investigation involving the flow visualization of high speed water jet, the noise reduction of the raw thermogram using a high-pass morphological filter ? and a median filter; the image enhancement using white top-hat filter; and the image segmentation using the multiple thresholding method. The image processing results by the designed morphological filters, ? - top-hat, were proved being ideal for further quantitative and in-depth analysis and can be used as a new morphological filter bank that may be of general implications for the analogous work

  13. Quantum and classical analysis of circular and sectorial billiards with central harmonic potential

    NASA Astrophysics Data System (ADS)

    Jurado-Taracena, Manuel; Plascencia, Alexis D.; Gutierrez-Vega, Julio C.

    2012-06-01

    We present the classical and quantum solutions to a particle confined in a circular sectorial billiard under a central harmonic potential, attractive and repulsive. The classical analysis is done by applying the Hamilton-Jacobi formalism; we derive the characteristic equations for periodic orbits, give expressions for the length of the trajectories in terms of elliptic integrals and study some geometrical constructions for the billiard. The quantum analysis leads to the study of the confluent hypergeometric function, from which we obtain the characteristic values for the energy spectra and the probability distributions inside the circular and sectorial billiard. As verification for the attractive case, as we increase the billiard radius our results approach the unbounded solutions. Finally we compare the classical probability distributions, obtained by assuming the probability as proportional to the time spent by the particle in each space interval, with the quantum ones.

  14. Using hydrophilic adhesive tape for collection of evidence for forensic DNA analysis.

    PubMed

    Li, Richard C; Harris, Howard A

    2003-11-01

    Known exemplar samples of human DNA have traditionally been body fluids, such as blood, saliva, and semen. In each case, the presence of water is a risk for the bacterial growth, which may degrade the DNA evidence. In this study, the authors have developed a method that employed a hydrophilic adhesive tape (HAT) for collecting DNA evidence. The HAT method was used to remove surface cells from relatively hairless areas on the body. The area examined were ankle, arm, behind the ear, between fingers and back of the neck. The HAT was then dissolved in the extraction buffer. DNA typing was performed at vWA, THo1, F13A1, and FES loci using the short tandem repeat (STR) analysis. Our results show that the samples collected from ear give the best results with a success rate of 100%. All subjects tested by this method had known STR genotypes established from buccal swabs. The authors' results suggest that the HAT method can be used as a less invasive method for collecting biological evidence for forensic DNA analysis. In addition, this collection method should reduce the risk of DNA degradation due to the moisture, which is encountered using conventional collecting methods.

  15. All Hat and No Cattle

    ERIC Educational Resources Information Center

    Holloway-Libell, Jessica; Amrein-Beardsley, Audrey; Collins, Clarin

    2012-01-01

    Recently, two of the authors (Amrein-Beardsley & Collins, 2012) studied the impact of Education Value-Added Assessment System (EVAAS), a value-added model used to judge Houston teachers' performance. They examined the cases of four teachers who were terminated in summer 2011, at least in part because of their subpar EVAAS scores. Talking to these…

  16. The Representational Value of Hats

    ERIC Educational Resources Information Center

    Watson, Jane M.; Fitzallen, Noleine E.; Wilson, Karen G.; Creed, Julie F.

    2008-01-01

    The literature that is available on the topic of representations in mathematics is vast. One commonly discussed item is graphical representations. From the history of mathematics to modern uses of technology, a variety of graphical forms are available for middle school students to use to represent mathematical ideas. The ideas range from algebraic…

  17. Gene panels to help identify subgroups at high and low risk of CHD among those randomized to antihypertensive treatment: The GenHAT Study

    PubMed Central

    Lynch, Amy I.; Eckfeldt, John H.; Davis, Barry R.; Ford, Charles E.; Boerwinkle, Eric; Leiendecker-Foster, Catherine; Arnett, Donna K.

    2012-01-01

    Objective To identify panels of genetic variants that predict treatment-related coronary heart disease (CHD) outcomes in hypertensive patients on one of four different classes of initial antihypertensive treatment. The goal was to identify subgroups of people based on their genetic profile who benefit most from a particular treatment. Methods Candidate genetic variants (n=78) were genotyped in 39,114 participants from GenHAT, ancillary to ALLHAT. ALLHAT randomized hypertensive participants (>=55 years) to one of four treatments (amlodipine, chlorthalidone, doxazosin, lisinopril). The primary outcome was fatal CHD or non-fatal MI (mean follow-up=4.9 years). A pharmacogenetic panel was derived within each of the four treatment groups. ROC curves estimated the discrimination rate between those with and without a CHD event, based on the addition of the genetic panel risk score. Results For each treatment group, we identified a panel of genetic variants that collectively improved prediction of CHD to a small but statistically significant extent. Chlorthalidone (A): NOS3, rs3918226; SELE, rs5361; ICAM1, rs1799969; AGT, rs5051; GNAS, rs7121; ROC comparison p=.004; Amlodipine (B): MMP1, rs1799750; F5, rs6025; NPPA, rs5065; PDE4D, rs6450512; MMP9, rs2274756; ROC comparison p=.006; Lisinopril (C): AGT, rs5051; PON1, rs705379; MMP12, rs652438; F12, rs1801020; GP1BA, rs6065; PDE4D, rs27653; ROC comparison p=.01; Doxazosin (D): F2, rs1799963; PAI1, rs1799768; MMP7, rs11568818; AGT, rs5051; ACE, rs4343; MMP2, rs243865; ROC comparison p=.007. Each panel was tested for a pharmacogenetic effect; panels A, B and D showed such evidence (p=.009, .006, and .001 respectively), panel C did not (p=.09). Conclusion Because each panel was associated with CHD in a specific treatment group but not the others, this research provides evidence that it may be possible to use gene panel scores as a tool to better assess antihypertensive treatment choices to reduce CHD risk in hypertensive

  18. Operations Nougat and Whetstone events: Hard Hat, Danny Boy, Marshmallow, Mudpack, Wishbone, Gumdrop, Diluted Waters, and Tiny Tot, 15 February 1962-17 June 1965. Final report 15 Feb 62-19 Jun 68

    SciTech Connect

    Brady, W.J.; Horton, K.K.; Eubank, B.F.

    1984-01-31

    This report is a personnel oriented history of DOD participation in underground nuclear weapons testing during Operations NOUGAT and WHETSTONE, test events HARD HAT, DANNY BOY, MARSHMALLOW, MUDPACK, WISHBONE, GUMDROP, DILUTED WATERS, and TINY TOT. It is the first in a series of historical reports which will include all DOD underground nuclear weapons tests and DOE underground nuclear weapons tests with significant DOD participation from 1962 forward. In addition to these volumes presenting a history of the underground nuclear test program, a later restricted volume will identify all DOD participants, (military, civilian, and their contractors) and will list their dosimetry data.

  19. Identifying conformational states of macromolecules by eigen-analysis of resampled cryo-EM images

    PubMed Central

    Penczek, Pawel A.; Kimmel, Marek; Spahn, Christian M.T.

    2012-01-01

    Summary We present the codimensional PCA, a novel and straightforward method for resolving sample heterogeneity within a set of cryo-EM 2D projection images of macromolecular assemblies. The method employs Principal Component Analysis (PCA) of resmapled 3D structures computed using subsets of 2D data obtained with a novel hypergeometric sampling scheme. PCA provides us with a small subset of dominating “eingevolumes” of the system, whose reprojections are compared with experimental projection data to yield their factorial coordinates constructed in a common framework of the 3D space of the macromolecule. Codimensional PCA is unique in the dramatic reduction of dimensionality of the problem, which facilitates rapid determination of both the plausible number of conformers in the sample and their 3D structures. We applied the codimensional PCA to a complex data set of T. thermophilus 70S ribosome, and we identified four major conformational states and visualized high mobility of the stalk base region. PMID:22078558

  20. Bayesian Geostatistical Analysis and Prediction of Rhodesian Human African Trypanosomiasis

    PubMed Central

    Wardrop, Nicola A.; Atkinson, Peter M.; Gething, Peter W.; Fèvre, Eric M.; Picozzi, Kim; Kakembo, Abbas S. L.; Welburn, Susan C.

    2010-01-01

    Background The persistent spread of Rhodesian human African trypanosomiasis (HAT) in Uganda in recent years has increased concerns of a potential overlap with the Gambian form of the disease. Recent research has aimed to increase the evidence base for targeting control measures by focusing on the environmental and climatic factors that control the spatial distribution of the disease. Objectives One recent study used simple logistic regression methods to explore the relationship between prevalence of Rhodesian HAT and several social, environmental and climatic variables in two of the most recently affected districts of Uganda, and suggested the disease had spread into the study area due to the movement of infected, untreated livestock. Here we extend this study to account for spatial autocorrelation, incorporate uncertainty in input data and model parameters and undertake predictive mapping for risk of high HAT prevalence in future. Materials and Methods Using a spatial analysis in which a generalised linear geostatistical model is used in a Bayesian framework to account explicitly for spatial autocorrelation and incorporate uncertainty in input data and model parameters we are able to demonstrate a more rigorous analytical approach, potentially resulting in more accurate parameter and significance estimates and increased predictive accuracy, thereby allowing an assessment of the validity of the livestock movement hypothesis given more robust parameter estimation and appropriate assessment of covariate effects. Results Analysis strongly supports the theory that Rhodesian HAT was imported to the study area via the movement of untreated, infected livestock from endemic areas. The confounding effect of health care accessibility on the spatial distribution of Rhodesian HAT and the linkages between the disease's distribution and minimum land surface temperature have also been confirmed via the application of these methods. Conclusions Predictive mapping indicates an

  1. Integrative Analysis Reveals Regulatory Programs in Endometriosis.

    PubMed

    Yang, Huan; Kang, Kai; Cheng, Chao; Mamillapalli, Ramanaiah; Taylor, Hugh S

    2015-09-01

    Endometriosis is a common gynecological disease found in approximately 10% of reproductive-age women. Gene expression analysis has been performed to explore alterations in gene expression associated with endometriosis; however, the underlying transcription factors (TFs) governing such expression changes have not been investigated in a systematic way. In this study, we propose a method to integrate gene expression with TF binding data and protein-protein interactions to construct an integrated regulatory network (IRN) for endometriosis. The IRN has shown that the most regulated gene in endometriosis is RUNX1, which is targeted by 14 of 26 TFs also involved in endometriosis. Using 2 published cohorts, GSE7305 (Hover, n = 20) and GSE7307 (Roth, n = 36) from the Gene Expression Omnibus database, we identified a network of TFs, which bind to target genes that are differentially expressed in endometriosis. Enrichment analysis based on the hypergeometric distribution allowed us to predict the TFs involved in endometriosis (n = 40). This included known TFs such as androgen receptor (AR) and critical factors in the pathology of endometriosis, estrogen receptor α, and estrogen receptor β. We also identified several new ones from which we selected FOXA2 and TFAP2C, and their regulation was confirmed by quantitative real-time polymerase chain reaction and immunohistochemistry (IHC). Further, our analysis revealed that the function of AR and p53 in endometriosis is regulated by posttranscriptional changes and not by differential gene expression. Our integrative analysis provides new insights into the regulatory programs involved in endometriosis.

  2. Multi-epoch Measurements of the Galactic Center 6667 MHz) and the Blazar 0716+714 (1 & 3 MHz) taken from the Allen Telescope Array at Hat Creek Radio Observatory in 2013

    NASA Astrophysics Data System (ADS)

    Castellanos, Aaron; Harp, G.

    2014-01-01

    The Allen Telescope Array (ATA) is a 42 radio dish array located in Hat Creek, CA and is used to search for traces of Extraterrestrial Intelligence (SETI) and to study the interstellar medium. The ATA has taken multi-epoch measurements of the Galactic Center 6667 MHz) and the intraday variable Blazar 0716+714 (1 & 3MHz) and are imaged on 10 second timescales to search for intensity fluctuations on timescales 10s and beyond. We utilize software developed and focused on antenna system temperatures to minimize Radio Frequency Interference (RFI) in order to enhance calibration and signal variability. We will discuss potential radio bursts from the Galactic Center, possibly originating from the descent of the gas cloud G2 into the Galactic Center.

  3. The Influence of Peripheral Substituent Modification on P(V), Mn(III), and Mn(V)(O) Corrolazines: X-ray Crystallography, Electrochemical and Spectroscopic Properties, and HAT and OAT Reactivities.

    PubMed

    Joslin, Evan E; Zaragoza, Jan Paulo T; Baglia, Regina A; Siegler, Maxime A; Goldberg, David P

    2016-09-01

    The influence of remote peripheral substitution on the physicochemical properties and reactivity of phosphorus and manganese corrolazine (Cz) complexes was examined. The substitution of p-MeO for p-t-Bu groups on the eight phenyl substituents of the β-carbon atoms of the Cz ring led to changes in UV-vis transitions and redox potentials for each of the complexes. The oxygen atom transfer (OAT) and hydrogen atom transfer (HAT) reactivity of the Mn(V)(O) complexes was also influenced by p-MeO substitution. The OAT reactivity of Mn(V)(O)(MeOP8Cz) (MeOP8Cz = octakis(p-methoxyphenyl)corrolazinato(3-)) with triarylphosphine (PAr3) substrates led to second-order rate constants from 10.2(5) to 3.1(2) × 10(4) M(-1) s(-1). These rates of OAT are slower than those seen for Mn(V)(O)(TBP8Cz) (TBP8Cz = octakis(p-tert-butylphenyl)corrolazinato(3-)). A Hammett study involving para-substituted PAr3 substrates reveals a Hammett ρ-value for Mn(V)(O)(MeOP8Cz) that is more negative than that observed for Mn(V)(O)(TBP8Cz), consistent with a less electrophilic Mn center. The HAT reactivity of Mn(V)(O)(MeOP8Cz) with C-H substrates was examined and revealed second-order rate constants from 6.8(5) × 10(-5) to 1.70(2) × 10(-1) M(-1) s(-1). The rate constants varied with the C-H bond strength of the substrate. Slightly faster HAT rates with C-H substrates were observed with Mn(V)(O)(MeOP8Cz) compared to Mn(V)(O)(TBP8Cz), indicating that the basicity of the putative [Mn(IV)(O)](-) intermediate likely compensates for the more negative redox potential in the driving force for HAT. In addition, the complete, large-scale synthesis of the para-phenyl-substituted porphyrazines RP8PzH2 (R = p-tert-butylphenyl (TB), p-methoxyphenyl (MeO), and p-isopropylphenyl) and corrolazines RP8CzH3 (TBP8CzH3 and MeOP8CzH3) is presented. The crystal structures of the monoprotonated, metal-free corrolazine [(TBP8CzH3)(H)](+)[BArF](-), P(V)(OMe)2(MeOP8Cz), and Mn(III)(MeOP8Cz)(MeOH) are presented. This work

  4. The Influence of Peripheral Substituent Modification on P(V), Mn(III), and Mn(V)(O) Corrolazines: X-ray Crystallography, Electrochemical and Spectroscopic Properties, and HAT and OAT Reactivities.

    PubMed

    Joslin, Evan E; Zaragoza, Jan Paulo T; Baglia, Regina A; Siegler, Maxime A; Goldberg, David P

    2016-09-01

    The influence of remote peripheral substitution on the physicochemical properties and reactivity of phosphorus and manganese corrolazine (Cz) complexes was examined. The substitution of p-MeO for p-t-Bu groups on the eight phenyl substituents of the β-carbon atoms of the Cz ring led to changes in UV-vis transitions and redox potentials for each of the complexes. The oxygen atom transfer (OAT) and hydrogen atom transfer (HAT) reactivity of the Mn(V)(O) complexes was also influenced by p-MeO substitution. The OAT reactivity of Mn(V)(O)(MeOP8Cz) (MeOP8Cz = octakis(p-methoxyphenyl)corrolazinato(3-)) with triarylphosphine (PAr3) substrates led to second-order rate constants from 10.2(5) to 3.1(2) × 10(4) M(-1) s(-1). These rates of OAT are slower than those seen for Mn(V)(O)(TBP8Cz) (TBP8Cz = octakis(p-tert-butylphenyl)corrolazinato(3-)). A Hammett study involving para-substituted PAr3 substrates reveals a Hammett ρ-value for Mn(V)(O)(MeOP8Cz) that is more negative than that observed for Mn(V)(O)(TBP8Cz), consistent with a less electrophilic Mn center. The HAT reactivity of Mn(V)(O)(MeOP8Cz) with C-H substrates was examined and revealed second-order rate constants from 6.8(5) × 10(-5) to 1.70(2) × 10(-1) M(-1) s(-1). The rate constants varied with the C-H bond strength of the substrate. Slightly faster HAT rates with C-H substrates were observed with Mn(V)(O)(MeOP8Cz) compared to Mn(V)(O)(TBP8Cz), indicating that the basicity of the putative [Mn(IV)(O)](-) intermediate likely compensates for the more negative redox potential in the driving force for HAT. In addition, the complete, large-scale synthesis of the para-phenyl-substituted porphyrazines RP8PzH2 (R = p-tert-butylphenyl (TB), p-methoxyphenyl (MeO), and p-isopropylphenyl) and corrolazines RP8CzH3 (TBP8CzH3 and MeOP8CzH3) is presented. The crystal structures of the monoprotonated, metal-free corrolazine [(TBP8CzH3)(H)](+)[BArF](-), P(V)(OMe)2(MeOP8Cz), and Mn(III)(MeOP8Cz)(MeOH) are presented. This work

  5. Towards understanding the presence/absence of Human African Trypanosomosis in a focus of Côte d'Ivoire: a spatial analysis of the pathogenic system

    PubMed Central

    Courtin, Fabrice; Jamonneau, Vincent; Oké, Emmanuel; Coulibaly, Bamoro; Oswald, Yohan; Dupont, Sophie; Cuny, Gérard; Doumenge, Jean-Pierre; Solano, Philippe

    2005-01-01

    Background This study aimed at identifying factors influencing the development of Human African Trypanosomosis (HAT, or sleeping sickness) in the focus of Bonon, located in the mesophile forest of Côte d'Ivoire. A previous study mapping the main daytime activity sites of 96 patients revealed an important disparity between the area south of the town- where all the patients lived- and the area north of the town, apparently free of disease. In order to explain this disparity, we carried out a spatial analysis of the key components of the pathogenic system, i.e. the human host, the tsetse vector and the trypanosomes in their environment using a geographic information system (GIS). Results This approach at the scale of a HAT focus enabled us to identify spatial patterns which linked to the transmission and the dissemination of this disease. The history of human settlement (with the rural northern area exploited much earlier than the southern one) appears to be a major factor which determines the land use pattern, which itself may account for differences found in vector densities (tsetse were found six times more abundant in the southern rural area than in the northern). Vector density, according to the human and environmental context in which it is found (here an intense mobility between the town of Bonon and the rural areas), may explain the observed spatial differences in HAT prevalence. Conclusion This work demonstrates the role of GIS analyses of key components of the pathogenic system in providing a better understanding of transmission and dissemination of HAT. Moreover, following the identification of the most active transmission areas, and of an area unfavourable to HAT transmission, this study more precisely delineates the boundaries of the Bonon focus. As a follow-up, targeted tsetse control activities starting north of Bonon (with few chances of reinvasion due to very low densities) going south, and additional medical surveys in the south will be proposed to

  6. Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics

    PubMed Central

    Tiberti, Natalia; Sanchez, Jean-Charles

    2015-01-01

    The quantitative proteomics data here reported are part of a research article entitled “Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense”, published by Tiberti et al., 2015. Transl. Proteomics 6, 1–9. Sleeping sickness (human African trypanosomiasis – HAT) is a deadly neglected tropical disease affecting mainly rural communities in sub-Saharan Africa. This parasitic disease is caused by the Trypanosoma brucei (T. b.) parasite, which is transmitted to the human host through the bite of the tse-tse fly. Two parasite sub-species, T. b. rhodesiense and T. b. gambiense, are responsible for two clinically different and geographically separated forms of sleeping sickness. The objective of the present study was to characterise and compare the cerebrospinal fluid (CSF) proteome of stage 2 (meningo-encephalitic stage) HAT patients suffering from T. b. gambiense or T. b. rhodesiense disease using high-throughput quantitative proteomics and the Tandem Mass Tag (TMT®) isobaric labelling. In order to evaluate the CSF proteome in the context of HAT pathophysiology, the protein dataset was then submitted to gene ontology and pathway analysis. Two significantly differentially expressed proteins (C-reactive protein and orosomucoid 1) were further verified on a larger population of patients (n=185) by ELISA, confirming the mass spectrometry results. By showing a predominant involvement of the acute immune response in rhodesiense HAT, the proteomics results obtained in this work will contribute to further understand the mechanisms of pathology occurring in HAT and to propose new biomarkers of potential clinical utility. The mass spectrometry raw data are available in the Pride Archive via ProteomeXchange through the identifier PXD001082. PMID:26306311

  7. The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex

    PubMed Central

    John, Sam; Howe, LeAnn; Tafrov, Stefan T.; Grant, Patrick A.; Sternglanz, Rolf; Workman, Jerry L.

    2000-01-01

    We have purified and characterized a Gcn5-independent nucleosomal histone H3 HAT complex, NuA3 (Nucleosomal Acetyltransferase of histone H3). Peptide sequencing of proteins from the purified NuA3 complex identified Sas3 as the catalytic HAT subunit of the complex. Sas3 is the yeast homolog of the human MOZ oncogene. Sas3 is required for both the HAT activity and the integrity of the NuA3 complex. In addition, NuA3 contains the TBP- associated factor, yTAFII30, which is also a component of the TFIID, TFIIF, and SWI/SNF complexes. Sas3 mediates interaction of the NuA3 complex with Spt16 both in vivo and in vitro. Spt16 functions as a component of the yeast CP (Cdc68/Pob3) and mammalian FACT (facilitates chromatin transcription) complexes, which are involved in transcription elongation and DNA replication. This interaction suggests that the NuA3 complex might function in concert with FACT–CP to stimulate transcription or replication elongation through nucleosomes by providing a coupled acetyltransferase activity. PMID:10817755

  8. Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease

    PubMed Central

    Forabosco, Paola; Neuhausen, Susan L.; Greco, Luigi; Naluai, Åsa Torinsson; Wijmenga, Cisca; Saavalainen, Päivi; Houlston, Richard S.; Ciclitira, Paul J.; Babron, Marie-Claude; Lewis, Cathryn M.

    2009-01-01

    Objective A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. Methods Here we apply the genome scan meta-analysis (GSMA) method, a rank-based, model-free approach, to combine results across eight independent genome-wide linkages performed on celiac disease (CD), including 554 families with over 1,500 affected individuals. We also investigate the agreement between signals we identified from this meta-analysis of linkage studies and those identified from genome-wide association analysis using a hypergeometric distribution. Results Not surprisingly, the most significant result was obtained in the HLA region. Outside the HLA region, suggestive evidence for linkage was obtained at the telomeric region of chromosome 10 (10q26.12-qter; p = 0.00366), and on chromosome 8 (8q22.2-q24.21; p = 0.00491). Testing signals of association and linkage within bins showed no significant evidence for co-localization of results. Conclusion This meta-analysis allowed us to pool the results from available genome-wide linkage studies and to identify novel regions potentially harboring predisposing genetic variation contributing to CD. This study also shows that linkage and association studies may identify different types of disease-predisposing variants. PMID:19622889

  9. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    NASA Technical Reports Server (NTRS)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  10. The effects of genes implicated in cardiovascular disease on blood-pressure response to treatment among treatment-naïve hypertensive African Americans in the GenHAT study

    PubMed Central

    Do, Anh N; Lynch, Amy I; Claas, Steven A; Boerwinkle, Eric; Davis, Barry R; Ford, Charles E; Eckfeldt, John H; Tiwari, Hemant K; Arnett, Donna K; Irvin, Marguerite R

    2015-01-01

    African Americans have the highest prevalence of hypertension in the United States. Blood-pressure control is important to reduce cardiovascular disease (CVD)-related morbidity and mortality in this ethnic group. Genetic variants have been found to be associated with BP response to treatment. Previous pharmacogenetic studies of blood-pressure response to treatment in African Americans suffer limitations of small sample size as well as a limited number of candidate genes, and often focused on one antihypertensive treatment. Using 1,131 African-American treatment naïve participants from the Genetics of Hypertension Associated Treatment (GenHAT) Study, we examined whether variants in 35 candidate genes might modulate blood-pressure response to four different antihypertensive medications, including an angiotensin converting enzyme (ACE) inhibitor (lisinopril), a calcium channel blocker (amlodipine), and an α-adrenergic blocker (doxazosin) as compared to a thiazide diuretic (chlorthalidone) after 6 months of follow-up. Several suggestive gene by treatment interactions were identified. For example, among participants with two minor alleles of REN rs6681776, diastolic blood-pressure response was much improved on doxazosin compared to chlorthalidone (on average −9.49 mmHg vs. −1.70 mmHg) (P=0.007). Although several suggestive loci were identified, none of the findings passed significance criteria after correction for multiple testing. Given the impact of hypertension and its sequelae in this population, this research highlights the potential for genetic factors to contribute to blood-pressure response to treatment. Continued concerted research efforts focused on genetics are needed to improve treatment response in this high risk group. PMID:26791477

  11. The ERTS-1 investigation (ER-600). Volume 4: ERTS-1 range analysis

    NASA Technical Reports Server (NTRS)

    Erb, R. B.

    1974-01-01

    The Range Analysis Team conducted an investigation to determine the utility of using LANDSAT 1 data for mapping vegetation-type information on range and related grazing lands. Two study areas within the Houston Area Test Site (HATS) were mapped to the highest classification level possible using manual image interpretation and computer aided classification techniques. Rangeland was distinguished from nonrangeland (water, urban area, and cropland) and was further classified as woodland versus nonwoodland. Finer classification of coastal features was attempted with some success in differentiating the lowland zone from the drier upland zone. Computer aided temporal analysis techniques enhanced discrimination among nearly all the vegetation types found in this investigation.

  12. Hats for Sale: A Salute to Directors.

    ERIC Educational Resources Information Center

    Ferguson, Sue

    Experiences related to pursuing excellence and a positive attitude as a campus childcare director are presented. The paper describes the emotional quotient (EQ) as a complex, multifaceted quality incorporating self- and social-awareness, empathy, optimism, and persistence that may predict one's success in certain kinds of work. Optimism may be…

  13. A hat trick - Plasmodium, Anopheles and Homo

    PubMed Central

    Ashburner, Michael

    2003-01-01

    The genomes of the malaria parasite, its vector and its host are now sequenced. This has been a tremendous scientific achievement. But will it offer hope to the millions who die from malaria each year? Yes, but only if combined with political will and social change. PMID:12537542

  14. Advanced nursing practice: old hat, new design.

    PubMed

    De Grasse, C; Nicklin, W

    2001-01-01

    Advanced practice nurses positively impact the delivery of healthcare and client outcomes. However, in the past these positions have been seen to have variable value and were often vulnerable during budget cuts. Lack of a clear advanced nursing practice (ANP) framework probably contributed to the compromised effectiveness of these roles and evolution of roles with different titles, scopes of practice and reporting structures. To build the foundation for developing an ANP framework, a task force at The Ottawa Hospital (TOH) conducted a literature review related to ANP roles and completed a review of all clinical nursing roles at TOH. In addition, focus groups with nurses and other health professionals elicited ANP perceptions. The ANP framework includes a standardized job description that details competencies under five role components: clinical practice; consultation; research; education; and, leadership. Recommendations for assessment, implementation and evaluation of ANP roles are identified. The process undertaken by our ANP task force proved to be thorough and sound in developing a framework within which to move forward with ANP role implementation throughout TOH. This article, describing the process, may assist other organizations in defining ANP roles to better meet patient needs in changing health care environments. PMID:11803945

  15. NLO Jet Physics with BlackHat

    SciTech Connect

    Berger, C.F.; Bern, Z.; Dixon, L.J.; Cordero, F.Febres; Forde, D.; Gleisberg, T.; Ita, H.; Kosower, D.A.; Maitre, D.; /Durham U.

    2010-02-15

    We present several results obtained using the BLACKHAT next-to-leading order QCD program library, in conjunction with SHERPA. In particular, we present distributions for vector boson plus 1,2,3-jet production at the Tevatron and at the asymptotic running energy of the Large Hadron Collider, including new Z + 3-jet distributions. The Z + 2-jet predictions for the second-jet P{sub T} distribution are compared to CDF data. We present the jet-emission probability at NLO in W + 2-jet events at the LHC, where the tagging jets are taken to be the ones furthest apart in pseudorapidity. We analyze further the large left-handed W{sup {+-}} polarization, identified in our previous study, for W bosons produced at high P{sub T} at the LHC.

  16. Minimum-mass design of filamentary composite panels under combined loads: Design procedure based on a rigorous buckling analysis

    NASA Technical Reports Server (NTRS)

    Stroud, W. J.; Agranoff, N.; Anderson, M. S.

    1977-01-01

    A procedure is presented for designing uniaxially stiffened panels made of composite material and subjected to combined inplane loads. The procedure uses a rigorous buckling analysis and nonlinear mathematical programing techniques. Design studies carried out with the procedure consider hat-stiffened and corrugated panels made of graphite-epoxy material. Combined longitudinal compression and shear and combined longitudinal and transverse compression are the loadings used in the studies. The capability to tailor the buckling response of a panel is also explored. Finally, the adequacy of another, simpler, analysis-design procedure is examined.

  17. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome.

    PubMed

    Kong, X D; Liu, N; Xu, X J

    2014-10-01

    In this study, biomarkers and transcriptional factor motifs were identified in order to investigate the etiology and phenotypic severity of Down syndrome. GSE 1281, GSE 1611, and GSE 5390 were downloaded from the gene expression ominibus (GEO). A robust multiarray analysis (RMA) algorithm was applied to detect differentially expressed genes (DEGs). In order to screen for biological pathways and to interrogate the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, the database for annotation, visualization, and integrated discovery (DAVID) was used to carry out a gene ontology (GO) function enrichment for DEGs. Finally, a transcriptional regulatory network was constructed, and a hypergeometric distribution test was applied to select for significantly enriched transcriptional factor motifs. CBR1, DYRK1A, HMGN1, ITSN1, RCAN1, SON, TMEM50B, and TTC3 were each up-regulated two-fold in Down syndrome samples compared to normal samples; of these, SON and TTC3 were newly reported. CBR1, DYRK1A, HMGN1, ITSN1, RCAN1, SON, TMEM50B, and TTC3 were located on human chromosome 21 (mouse chromosome 16). The DEGs were significantly enriched in macromolecular complex subunit organization and focal adhesion pathways. Eleven significantly enriched transcription factor motifs (PAX5, EGR1, XBP1, SREBP1, OLF1, MZF1, NFY, NFKAPPAB, MYCMAX, NFE2, and RP58) were identified. The DEGs and transcription factor motifs identified in our study provide biomarkers for the understanding of Down syndrome pathogenesis and progression. PMID:25118625

  18. The Multi-index Mittag-Leffler Functions and Their Applications for Solving Fractional Order Problems in Applied Analysis

    NASA Astrophysics Data System (ADS)

    Kiryakova, V. S.; Luchko, Yu. F.

    2010-11-01

    During the last few decades, differential equations and systems of fractional order (that is arbitrary one, not necessarily integer) begun to play an important role in modeling of various phenomena of physical, engineering, automatization, biological and biomedical, chemical, earth, economics, social relations, etc. nature. The so-called Special Functions of Fractional Calculus (SF of FC) provide an important tool of Fractional Calculus (FC) and Applied Analysis (AA). In particular, they are often used to represent the solutions of fractional differential equations in explicit form. Among the most popular representatives of the SF of FC are: the Mittag-Leffler (ML) function, the Wright generalized hypergeometric function pΨq, the more general Fox H-function, and the Inayat-HussainH-function. The classical Special Functions (called also SF of Mathematical Physics), including the orthogonal polynomials, and the pFq-hypergeometric functions fall in this scheme as examples of the simpler Meijer G-function. In this survey talk, we overview the properties and some applications of an important class of SF of FC, introduced for the first time in our works. For integer m>1 and arbitrary real (or complex, under suitable restrictions) indices ρ1,…,ρm>0 and μ1,…,μm, we define the multi-index (vector-index) Mittag-Leffler functions by: E(1/ρi),(μi)(z) = E)1/ρi),(μi)(m)(z) = ∑ K=0∞zk/Γ(μ1+kρ1)…Γ(μm+k/ρm) = 1Ψm[(1,1)(μ1,1/ρi)1m;z] = H1,m+11,1[-z‖(0,1)(0,1),(1-μi,1/ρi)1m]. We propose also a list of examples of SF of FC that are E(1/ρi),(μi)-functions and play important role in pure mathematics and in solving problems from natural, applied and social sciences, and state

  19. A Perturbative Analysis of Synchrotron Spectral Index Variation over the Microwave Sky

    NASA Astrophysics Data System (ADS)

    Saha, Rajib; Aluri, Pavan K.

    2016-10-01

    In this paper, we implement a perturbative approach, first proposed by Bouchet & Gispert, to estimate the variation of the spectral index of galactic polarized synchrotron emission, using a linear combination of simulated Stokes Q polarization maps of selected frequency bands from WMAP and Planck observations on a region of sky dominated by the synchrotron Stokes Q signal. We find that a first order perturbative analysis recovers the input spectral index map well. Along with the spectral index variation map, our method provides a fixed reference index, {\\hat{β }}0s, over the sky portion being analyzed. Using Monte-Carlo simulations, we find that < {\\hat{β }}0s> =-2.84+/- 0.01, which matches very closely with the position of a peak at {β }s(p)=-2.85 of the empirical probability density function of input synchrotron indices obtained from the same sky region. For thermal dust, the mean recovered spectral index < {\\hat{β }}d> =2.00+/- 0.004 from simulations, matches very well with the spatially fixed input thermal dust spectral index {β }d=2.00. As accompanying results of the method, we reconstruct cosmic microwave background, thermal dust, and a synchrotron template components with fixed spectral indices over the entire sky region. We use, in our analysis, full pixel-pixel noise covariance matrices of all frequency bands, estimated from the sky region being analyzed. The perturbative technique of this work (1) can build a model with an arbitrary but sufficient degree of accuracy (and precession) as allowed by the data and (2) can produce maximum likelihood estimators for reference indices and templates asymptotically.

  20. Wavelet analysis for wind fields estimation.

    PubMed

    Leite, Gladeston C; Ushizima, Daniela M; Medeiros, Fátima N S; de Lima, Gilson G

    2010-01-01

    Wind field analysis from synthetic aperture radar images allows the estimation of wind direction and speed based on image descriptors. In this paper, we propose a framework to automate wind direction retrieval based on wavelet decomposition associated with spectral processing. We extend existing undecimated wavelet transform approaches, by including à trous with B(3) spline scaling function, in addition to other wavelet bases as Gabor and Mexican-hat. The purpose is to extract more reliable directional information, when wind speed values range from 5 to 10 ms(-1). Using C-band empirical models, associated with the estimated directional information, we calculate local wind speed values and compare our results with QuikSCAT scatterometer data. The proposed approach has potential application in the evaluation of oil spills and wind farms.

  1. Wavelet Analysis for Wind Fields Estimation

    PubMed Central

    Leite, Gladeston C.; Ushizima, Daniela M.; Medeiros, Fátima N. S.; de Lima, Gilson G.

    2010-01-01

    Wind field analysis from synthetic aperture radar images allows the estimation of wind direction and speed based on image descriptors. In this paper, we propose a framework to automate wind direction retrieval based on wavelet decomposition associated with spectral processing. We extend existing undecimated wavelet transform approaches, by including à trous with B3 spline scaling function, in addition to other wavelet bases as Gabor and Mexican-hat. The purpose is to extract more reliable directional information, when wind speed values range from 5 to 10 ms−1. Using C-band empirical models, associated with the estimated directional information, we calculate local wind speed values and compare our results with QuikSCAT scatterometer data. The proposed approach has potential application in the evaluation of oil spills and wind farms. PMID:22219699

  2. Wavelet analysis for wind fields estimation.

    PubMed

    Leite, Gladeston C; Ushizima, Daniela M; Medeiros, Fátima N S; de Lima, Gilson G

    2010-01-01

    Wind field analysis from synthetic aperture radar images allows the estimation of wind direction and speed based on image descriptors. In this paper, we propose a framework to automate wind direction retrieval based on wavelet decomposition associated with spectral processing. We extend existing undecimated wavelet transform approaches, by including à trous with B(3) spline scaling function, in addition to other wavelet bases as Gabor and Mexican-hat. The purpose is to extract more reliable directional information, when wind speed values range from 5 to 10 ms(-1). Using C-band empirical models, associated with the estimated directional information, we calculate local wind speed values and compare our results with QuikSCAT scatterometer data. The proposed approach has potential application in the evaluation of oil spills and wind farms. PMID:22219699

  3. Analysis

    NASA Astrophysics Data System (ADS)

    Abdelazeem, Maha; El-Sawy, El-Sawy K.; Gobashy, Mohamed M.

    2013-06-01

    Ar Rika fault zone constitutes one of the two major parts of the NW-SE Najd fault system (NFS), which is one of the most prominent structural features located in the east of the center of the Arabian Shield, Saudi Arabia. By using Enhancement Thematic Mapper data (ETM+) and Principle Component Analysis (PCA), surface geological characteristics, distribution of rock types, and the different trends of linear features and faults are determined in the study area. First and second order magnetic gradients of the geomagnetic field at the North East of Wadi Ar Rika have been calculated in the frequency domain to map both surface and subsurface lineaments and faults. Lineaments as deduced from previous studies, suggest an extension of the NFS beneath the cover rocks in the study area. In the present study, integration of magnetic gradients and remote sensing analysis that resulted in different valuable derivative maps confirm the subsurface extension of some of the surface features. The 3D Euler deconvolution, the total gradient, and the tilt angle maps have been utilized to determine accurately the distribution of shear zones, the tectonic implications, and the internal structures of the terranes in the Ar Rika quadrangle in three dimensions.

  4. Modal Analysis in Lined Wedge-Shaped Ducts

    NASA Astrophysics Data System (ADS)

    Mechel, F. P.

    1998-10-01

    It has been suggested to describe the sound field in a wedge-shaped duct in a cylindrical co-ordinate system in which the boundaries of the wedge lie in a co-ordinate surface. This suggestion was developed in a companion paper [1]. The wave equation can be separated only if the boundaries are ideally reflecting (rigid or soft). Two solutions were proposed in reference [1] for absorbing boundaries. In the first solution the sound field is composed of “ideal modes” (modes in a wedge with ideally reflecting boundaries); the boundary condition at the absorbing boundary then leads to a system of equations for the mode amplitudes. The problem with this method lies in the fact that there is no radial orthogonality of the ideal modes so that the precision of the field synthesis by ideal modes is doubtful. In the second method in reference [1] one defines “fictitious modes” which satisfy the boundary conditions at the flanks exactly and which are based on hypergeometric functions as radial functions, but which produce a “rest” in the wave equation. It was described how this rest can be minimized; this procedure leads to slow numerical integrations. In the present paper, the wedge is subdivided into duct sections with parallel walls (the boundary is stepped); the fields in the sections are composed of duct modes (modes in a straight lined duct); the mode amplitudes are determined from the boundary conditions at the section limits. The advantages of the present method are (analytically) the duct modes are orthogonal across the sections, so the mode amplitudes can be determined with the usual precision of a modal analysis, and (numerically) no numerical integrations are needed.

  5. Analysis of ΔO2/ΔCO2 ratios for the pollution events observed at Hateruma Island, Japan

    NASA Astrophysics Data System (ADS)

    Minejima, C.; Kubo, M.; Tohjima, Y.; Yamagishi, H.; Koyama, Y.; Maksyutov, S.; Kita, K.; Mukai, H.

    2011-05-01

    In-situ observations of atmospheric CO2 and O2 concentrations at Hateruma Island (HAT, 24° N, 124° E) often show synoptic scale pollution events when air masses are transported from East Asian source regions. We calculate the regression slopes (-ΔO2/ΔCO2 molar ratios) of the correlation plots between O2 and CO2 for selected pollution events observed between October 2006 and December 2008. The observed -ΔO2/ΔCO2 ratios vary from 1.0 to 1.7. Categorizing the air mass origins for the pollution events by using back trajectory analysis, we find that there is a significant difference in the average -ΔO2/ΔCO2 ratios between events from China (1.14±0.12, n = 25) and Japan/Korea (1.37±0.15, n = 16). These values are comparable to the -O2:CO2 molar exchange ratios, which are estimated from the national fossil fuel inventories from CDIAC. Simulations using a particle dispersion model reveal that the pollution events at HAT are predominantly CO2 emissions from the combustion of fossil fuels in East Asian countries, which is consistent with the above observational results. Although the average value of the model-predicted -ΔO2/ΔCO2 ratios for Japan/Korea origin is underestimated in comparison with the observation, that for China origin agree well with the observation. The sensitivity experiment suggests that the -ΔO2/ΔCO2 ratio at HAT reflects about 90% of the change in the -O2:CO2 exchange ratio for the fossil carbon emissions from China.

  6. ACT Payload Shroud Structural Concept Analysis and Optimization

    NASA Technical Reports Server (NTRS)

    Zalewski, Bart B.; Bednarcyk, Brett A.

    2010-01-01

    Aerospace structural applications demand a weight efficient design to perform in a cost effective manner. This is particularly true for launch vehicle structures, where weight is the dominant design driver. The design process typically requires many iterations to ensure that a satisfactory minimum weight has been obtained. Although metallic structures can be weight efficient, composite structures can provide additional weight savings due to their lower density and additional design flexibility. This work presents structural analysis and weight optimization of a composite payload shroud for NASA s Ares V heavy lift vehicle. Two concepts, which were previously determined to be efficient for such a structure are evaluated: a hat stiffened/corrugated panel and a fiber reinforced foam sandwich panel. A composite structural optimization code, HyperSizer, is used to optimize the panel geometry, composite material ply orientations, and sandwich core material. HyperSizer enables an efficient evaluation of thousands of potential designs versus multiple strength and stability-based failure criteria across multiple load cases. HyperSizer sizing process uses a global finite element model to obtain element forces, which are statistically processed to arrive at panel-level design-to loads. These loads are then used to analyze each candidate panel design. A near optimum design is selected as the one with the lowest weight that also provides all positive margins of safety. The stiffness of each newly sized panel or beam component is taken into account in the subsequent finite element analysis. Iteration of analysis/optimization is performed to ensure a converged design. Sizing results for the hat stiffened panel concept and the fiber reinforced foam sandwich concept are presented.

  7. Coupled 2D-3D finite element method for analysis of a skin panel with a discontinuous stiffener

    NASA Technical Reports Server (NTRS)

    Wang, J. T.; Lotts, C. G.; Davis, D. D., Jr.; Krishnamurthy, T.

    1992-01-01

    This paper describes a computationally efficient analysis method which was used to predict detailed stress states in a typical composite compression panel with a discontinuous hat stiffener. A global-local approach was used. The global model incorporated both 2D shell and 3D brick elements connected by newly developed transition elements. Most of the panel was modeled with 2D elements, while 3D elements were employed to model the stiffener flange and the adjacent skin. Both linear and geometrically nonlinear analyses were performed on the global model. The effect of geometric nonlinearity induced by the eccentric load path due to the discontinuous hat stiffener was significant. The local model used a fine mesh of 3D brick elements to model the region at the end of the stiffener. Boundary conditions of the local 3D model were obtained by spline interpolation of the nodal displacements from the global analysis. Detailed in-plane and through-the-thickness stresses were calculated in the flange-skin interface near the end of the stiffener.

  8. BEER Analysis of Kepler and CoRoT Light Curves. II. Evidence for Superrotation in the Phase Curves of Three Kepler Hot Jupiters

    NASA Astrophysics Data System (ADS)

    Faigler, S.; Mazeh, T.

    2015-02-01

    We analyzed the Kepler light curves of four transiting hot Jupiter systems—KOI-13, HAT-P-7, TrES-2, and Kepler-76, which show BEaming, Ellipsoidal, and Reflection (BEER) phase modulations. The mass of the four planets can be estimated from either the beaming or the ellipsoidal amplitude, given the mass and radius of their parent stars. For KOI-13, HAT-P-7, and Kepler-76 we find that the beaming-based planetary mass estimate is larger than the mass estimated from the ellipsoidal amplitude, consistent with previous studies. This apparent discrepancy may be explained by equatorial superrotation of the planet atmosphere, which induces an angle shift of the planet reflection/emission phase modulation, as was suggested for Kepler-76 in the first paper of this series. We propose a modified BEER model that supports superrotation, assuming either a Lambertian or geometric reflection/emission phase function, and provides a photometry-consistent estimate of the planetary mass. Our analysis shows that for Kepler-76 and HAT-P-7, the Lambertian superrotation BEER model is highly preferable over an unshifted null model, while for KOI-13 it is preferable only at a 1.4σ level. For TrES-2 we do not find such preference. For all four systems the Lambertian superrotation model mass estimates are in excellent agreement with the planetary masses derived from, or constrained by, radial velocity measurements. This makes the Lambertian superrotation BEER model a viable tool for estimating the masses of hot Jupiters from photometry alone. We conclude that hot Jupiter superrotation may be a common phenomenon that can be detected in the visual light curves of Kepler.

  9. BEER ANALYSIS OF KEPLER AND CoRoT LIGHT CURVES. II. EVIDENCE FOR SUPERROTATION IN THE PHASE CURVES OF THREE KEPLER HOT JUPITERS

    SciTech Connect

    Faigler, S.; Mazeh, T.

    2015-02-10

    We analyzed the Kepler light curves of four transiting hot Jupiter systems—KOI-13, HAT-P-7, TrES-2, and Kepler-76, which show BEaming, Ellipsoidal, and Reflection (BEER) phase modulations. The mass of the four planets can be estimated from either the beaming or the ellipsoidal amplitude, given the mass and radius of their parent stars. For KOI-13, HAT-P-7, and Kepler-76 we find that the beaming-based planetary mass estimate is larger than the mass estimated from the ellipsoidal amplitude, consistent with previous studies. This apparent discrepancy may be explained by equatorial superrotation of the planet atmosphere, which induces an angle shift of the planet reflection/emission phase modulation, as was suggested for Kepler-76 in the first paper of this series. We propose a modified BEER model that supports superrotation, assuming either a Lambertian or geometric reflection/emission phase function, and provides a photometry-consistent estimate of the planetary mass. Our analysis shows that for Kepler-76 and HAT-P-7, the Lambertian superrotation BEER model is highly preferable over an unshifted null model, while for KOI-13 it is preferable only at a 1.4σ level. For TrES-2 we do not find such preference. For all four systems the Lambertian superrotation model mass estimates are in excellent agreement with the planetary masses derived from, or constrained by, radial velocity measurements. This makes the Lambertian superrotation BEER model a viable tool for estimating the masses of hot Jupiters from photometry alone. We conclude that hot Jupiter superrotation may be a common phenomenon that can be detected in the visual light curves of Kepler.

  10. Enrichment Analysis Identifies Functional MicroRNA-Disease Associations in Humans.

    PubMed

    Yuan, Dandan; Cui, Xiaomeng; Wang, Yang; Zhao, Yilei; Li, Huiying; Hu, Suangjiu; Chu, Xiaodan; Li, Yan; Li, Qiang; Liu, Qian; Zhu, Wenliang

    2015-01-01

    Substantial evidence has shown that microRNAs (miRNAs) may be causally linked to the occurrence and progression of human diseases. Herein, we conducted an enrichment analysis to identify potential functional miRNA-disease associations (MDAs) in humans by integrating currently known biological data: miRNA-target interactions (MTIs), protein-protein interactions, and gene-disease associations. Two contributing factors to functional miRNA-disease associations were quantitatively considered: the direct effects of miRNA that target disease-related genes, and indirect effects triggered by protein-protein interactions. Ninety-nine miRNAs were scanned for possible functional association with 2223 MeSH-defined human diseases. Each miRNA was experimentally validated to target ≥ 10 mRNA genes. Putative MDAs were identified when at least one MTI was confidently validated for a disease. Overall, 19648 putative MDAs were found, of which 10.0% was experimentally validated. Further results suggest that filtering for miRNAs that target a greater number of disease-related genes (n ≥ 8) can significantly enrich for true MDAs from the set of putative associations (enrichment rate = 60.7%, adjusted hypergeometric p = 2.41×10-91). Considering the indirect effects of miRNAs further elevated the enrichment rate to 72.6%. By using this method, a novel MDA between miR-24 and ovarian cancer was found. Compared with scramble miRNA overexpression of miR-24 was validated to remarkably induce ovarian cancer cells apoptosis. Our study provides novel insight into factors contributing to functional MDAs by integrating large quantities of previously generated biological data, and establishes a feasible method to identify plausible associations with high confidence. PMID:26296081

  11. Increasing conclusiveness of clinical breath analysis by improved baseline correction of multi capillary column - ion mobility spectrometry (MCC-IMS) data.

    PubMed

    Szymańska, Ewa; Tinnevelt, Gerjen H; Brodrick, Emma; Williams, Mark; Davies, Antony N; van Manen, Henk-Jan; Buydens, Lutgarde M C

    2016-08-01

    Current challenges of clinical breath analysis include large data size and non-clinically relevant variations observed in exhaled breath measurements, which should be urgently addressed with competent scientific data tools. In this study, three different baseline correction methods are evaluated within a previously developed data size reduction strategy for multi capillary column - ion mobility spectrometry (MCC-IMS) datasets. Introduced for the first time in breath data analysis, the Top-hat method is presented as the optimum baseline correction method. A refined data size reduction strategy is employed in the analysis of a large breathomic dataset on a healthy and respiratory disease population. New insights into MCC-IMS spectra differences associated with respiratory diseases are provided, demonstrating the additional value of the refined data analysis strategy in clinical breath analysis.

  12. Increasing conclusiveness of clinical breath analysis by improved baseline correction of multi capillary column - ion mobility spectrometry (MCC-IMS) data.

    PubMed

    Szymańska, Ewa; Tinnevelt, Gerjen H; Brodrick, Emma; Williams, Mark; Davies, Antony N; van Manen, Henk-Jan; Buydens, Lutgarde M C

    2016-08-01

    Current challenges of clinical breath analysis include large data size and non-clinically relevant variations observed in exhaled breath measurements, which should be urgently addressed with competent scientific data tools. In this study, three different baseline correction methods are evaluated within a previously developed data size reduction strategy for multi capillary column - ion mobility spectrometry (MCC-IMS) datasets. Introduced for the first time in breath data analysis, the Top-hat method is presented as the optimum baseline correction method. A refined data size reduction strategy is employed in the analysis of a large breathomic dataset on a healthy and respiratory disease population. New insights into MCC-IMS spectra differences associated with respiratory diseases are provided, demonstrating the additional value of the refined data analysis strategy in clinical breath analysis. PMID:26879424

  13. Next-generation sequencing facilitates quantitative analysis of wild-type and Nrl−/− retinal transcriptomes

    PubMed Central

    Brooks, Matthew J.; Rajasimha, Harsha K.; Roger, Jerome E.

    2011-01-01

    Purpose Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived retinal transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis. Methods Retinal mRNA profiles of 21-day-old wild-type (WT) and neural retina leucine zipper knockout (Nrl−/−) mice were generated by deep sequencing, in triplicate, using Illumina GAIIx. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. qRT–PCR validation was performed using TaqMan and SYBR Green assays. Results Using an optimized data analysis workflow, we mapped about 30 million sequence reads per sample to the mouse genome (build mm9) and identified 16,014 transcripts in the retinas of WT and Nrl−/− mice with BWA workflow and 34,115 transcripts with TopHat workflow. RNA-seq data confirmed stable expression of 25 known housekeeping genes, and 12 of these were validated with qRT–PCR. RNA-seq data had a linear relationship with qRT–PCR for more than four orders of magnitude and a goodness of fit (R2) of 0.8798. Approximately 10% of the transcripts showed differential expression between the WT and Nrl−/− retina, with a fold change ≥1.5 and p value <0.05. Altered expression of 25 genes was confirmed with qRT–PCR, demonstrating the high degree of sensitivity of the RNA-seq method. Hierarchical clustering of differentially expressed genes uncovered several as yet uncharacterized genes that may contribute to retinal function. Data analysis with BWA and TopHat workflows revealed a significant overlap yet provided complementary insights in transcriptome profiling. Conclusions Our study represents the first detailed analysis of retinal

  14. Analysis of gas absorption to a thin liquid film in the presence of a zero-order chemical reaction

    NASA Technical Reports Server (NTRS)

    Rajagopalan, S.; Rahman, M. M.

    1995-01-01

    The paper presents a detailed theoretical analysis of the process of gas absorption to a thin liquid film adjacent to a horizontal rotating disk. The film is formed by the impingement of a controlled liquid jet at the center of the disk and subsequent radial spreading of liquid along the disk. The chemical reaction between the gas and the liquid film can be expressed as a zero-order homogeneous reaction. The process was modeled by establishing equations for the conservation of mass, momentum, and species concentration and solving them analytically. A scaling analysis was used to determine dominant transport processes. Appropriate boundary conditions were used to solve these equations to develop expressions for the local concentration of gas across the thickness of the film and distributions of film height, bulk concentration, and Sherwood number along the radius of the disk. The partial differential equation for species concentration was solved using the separation of variables technique along with the Duhamel's theorem and the final analytical solution was expressed using confluent hypergeometric functions. Tables for eigenvalues and eigenfunctions are presented for a number of reaction rate constants. A parametric study was performed using Reynolds number, Ekman number, and dimensionless reaction rate as parameters. At all radial locations, Sherwood number increased with Reynolds number (flow rate) as well as Ekman number (rate of rotation). The enhancement of mass transfer due to chemical reaction was found to be small when compared to the case of no reaction (pure absorption), but the enhancement factor was very significant when compared to pure absorption in a stagnant liquid film. The zero-order reaction processes considered in the present investigation included the absorption of oxygen in aqueous alkaline solutions of sodiumdithionite and rhodium complex catalyzed carbonylation of methanol. Present analytical results were compared to previous theoretical

  15. Springback analysis for the stamping of an automotive part with high strength steel sheet

    NASA Astrophysics Data System (ADS)

    Hung, Tzu-Hao; Tsai, Heng-Kuang; Chang, Chih-Kai; Hsu, Yu-Hung; Chen, Fuh-Kuo; Chung, Kuo-Hsin

    2013-05-01

    The study of springback analysis of 440MPa high strength steel is investigated in this paper. Because of the springback phenomenon is related to the material properties and the deformation mechanism during the forming process, the material properties of 440MPa high strength steel are studied at first. The material properties of 440MPa high strength steel are obtained by conducting cyclic uniaxial tension-compression tests with different strain ranges. In order to apply the material properties obtained from the experiments to the finite element analysis, the material constants required in the Yoshida-Uemori model (Y-U model) with the Bauschinger effect considered are established. For realizing the springback characteristics of 440MPa high strength steel, the U-hat draw-bending and V-shape bending are examined by the finite element analysis. From the simulation results, it finds that the side wall curl phenomenon occurs in the U-hat drawbending and the springback phenomenon appears in the V-shape bending. Moreover, it also shows that the side wall curl phenomenon and springback phenomenon are more obvious in the finite element simulations with the Bauschinger effect considered. Finally, the validation of springback prediction is performed by stamping an engine hood reinforcement with 440MPa high strength steel sheet. From the stamping results, it shows that the simulation results of springback prediction are in a well agreement to the production part data. It also finds that the springback predictions are more accurate by the finite element simulations with the use of the Y-U model. It is also found that for a stamping part which is subjected to a reversed tension-compression deformation in the forming process, the occurrence of the Bauschinger effect is obvious. It is also concluded that the accuracy of springback prediction can be much improved by the use of material model with the Bauschinger effect considered.

  16. [Wavelet analysis on SO2 pollution index changes of Shanghai in recent 10 years].

    PubMed

    Wu, Xiao-ling; Zhang, Bin; Ai, Nan-shan; Liu, Li-jun

    2009-08-15

    Based on the continuous Mexican Hat wavelet transformation of time series of daily SO2 pollution index during last 10 years in Shanghai, the multiscale variations, primary period, catastrophe point and influencing factors are analyzed. The result shows that periodical fluctuation of SO2 pollution index varies at diverse time-scales, and the primary period of the daily variations is about 100 days; pollution pattern takes on serious in winter and light in summer in most scales due to meteorological conditions, and the catastrophe point of serious-light transformation of SO2 pollution index in a year is vernal and autumnal equinox; energy demand and socioeconomic development result in more seriousness in recent years and half result with twice the effort of endeavors of pollution elimination. Wavelet analysis is an effective method to time series of SO2 pollution index, also to multiscale variations of other pollutants. PMID:19799273

  17. Census taking in the hat: FRW/CFT duality

    SciTech Connect

    Sekino, Yasuhiro; Susskind, Leonard

    2009-10-15

    In this paper a holographic description of eternal inflation is developed. We focus on the description of an open Friedmann-Robertson-Walker (FRW) universe that results from a tunneling event in which a false vacuum with positive vacuum energy decays to a supersymmetric vacuum with vanishing cosmological constant. The observations of a 'census taker' in the final vacuum can be organized into a holographic dual conformal field theory that lives on the asymptotic boundary of space. We refer to this bulk-boundary correspondence as FRW/CFT duality. The dual conformal field theory (CFT) is a Euclidean two-dimensional theory that includes a Liouville 2D gravity sector describing geometric fluctuations of the boundary. The renormalization-group flow of the theory is richer than in the AdS/CFT correspondence, and generates two space-time dimensions--one spacelike and one timelike. We discuss a number of phenomena such as bubble collisions, and the Garriga, Guth Vilenkin 'persistence of memory', from the dual viewpoint.

  18. Transitioning to Teacher: Uncertainty as a Game of Dramatic Hats

    ERIC Educational Resources Information Center

    Sinner, Anita

    2012-01-01

    Nathalie's experience of becoming a teacher demonstrates how a counter-narrative contributes to negotiating dominant discourses that propagate stories of uniformity and reinforce the status quo within the teaching profession. By offering an alternate perspective of teacher culture as a liminal space, uncertainty symbolizes Nathalie's transition to…

  19. Middle School Girls Sample "Hard Hat" Life at Construction Camp

    ERIC Educational Resources Information Center

    Brown, Aneeta

    2013-01-01

    On a Monday morning in July, a fan as tall as a refrigerator churned noisily in the cavernous classroom. As the outdoor temperature crept higher, teenage girls wearing hardhats and safety glasses wiped perspiration and sawdust from their faces. This was not a field trip. This was the second hour of camp at Ranken Technical College in St. Louis,…

  20. Pulling Words Out of a Hat: Magic in ESL Lessons.

    ERIC Educational Resources Information Center

    Friedenberg, Randi D.

    Magic motivates students to talk, and stimulates the affective domain. While watching magic, many people imagine how the effect is accomplished or how they might perform the trick if they were performing. This can be extended into an English lesson by using phrases such as, "If I were a magician, I could..." Total physical response activities take…

  1. QUANTUM MECHANICS: Enhanced: Schrodinger's Cat Is Out of the Hat.

    PubMed

    Tesche, C

    2000-10-27

    In 1935, Erwin Schrödinger suggested his famous gedanken experiment of the cat that is simultaneously "dead" and "alive" inside its box until the box is opened. But as Tesche explains in her Perspective, such a macroscopic manifestation of quantum mechanics has remained elusive until recently. The experiments by van der Wal et al. are an important step toward demonstrating that quantum mechanics can describe macroscopic phenomena. The approach may be exploited in quantum computing and quantum cryptography.

  2. Pants and Hats: Dress Codes and Expressive Conduct as Speech.

    ERIC Educational Resources Information Center

    DeMitchell, Todd A.

    1999-01-01

    It has been 30 years since the U.S. Supreme Court, in the "Tinker" case, upheld three students' right to wear black armbands protesting the Vietnam War to school. Recent cases involving sagging pants and an African headwrap (dress code violations) did not meet allowable "free-speech" requirements. (MLH)

  3. Composite Structure Modeling and Analysis of Advanced Aircraft Fuselage Concepts

    NASA Technical Reports Server (NTRS)

    Mukhopadhyay, Vivek; Sorokach, Michael R.

    2015-01-01

    NASA Environmentally Responsible Aviation (ERA) project and the Boeing Company are collabrating to advance the unitized damage arresting composite airframe technology with application to the Hybrid-Wing-Body (HWB) aircraft. The testing of a HWB fuselage section with Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) construction is presently being conducted at NASA Langley. Based on lessons learned from previous HWB structural design studies, improved finite-element models (FEM) of the HWB multi-bay and bulkhead assembly are developed to evaluate the performance of the PRSEUS construction. In order to assess the comparative weight reduction benefits of the PRSEUS technology, conventional cylindrical skin-stringer-frame models of a cylindrical and a double-bubble section fuselage concepts are developed. Stress analysis with design cabin-pressure load and scenario based case studies are conducted for design improvement in each case. Alternate analysis with stitched composite hat-stringers and C-frames are also presented, in addition to the foam-core sandwich frame and pultruded rod-stringer construction. The FEM structural stress, strain and weights are computed and compared for relative weight/strength benefit assessment. The structural analysis and specific weight comparison of these stitched composite advanced aircraft fuselage concepts demonstrated that the pressurized HWB fuselage section assembly can be structurally as efficient as the conventional cylindrical fuselage section with composite stringer-frame and PRSEUS construction, and significantly better than the conventional aluminum construction and the double-bubble section concept.

  4. Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years.

    PubMed

    Mwanakasale, Victor; Songolo, Peter

    2011-03-01

    We conducted a situation analysis of human African trypanosomiasis (HAT) in Zambia from January 2000 to April 2007. The aim of this survey was to identify districts in Zambia that were still recording cases of HAT. Three districts namely, Mpika, Chama, and Chipata were found to be still reporting cases of HAT and thus lay in HAT transmission foci in North Eastern Zambia. During the period under review, 24 cases of HAT were reported from these three districts. We thereafter reviewed literature on the occurrence of HAT in Zambia from the early 1960s to mid 1990s. This revealed that HAT transmission foci were widespread in Western, North Western, Lusaka, Eastern, Luapula, and Northern Provinces of Zambia during this period. In this article we have tried to give possible reasons as to why the distribution of HAT transmission foci is so different between before and after 2000 when there has been no active national tsetse fly and trypanosomiasis control program in Zambia.

  5. Analysis of a model of gambiense sleeping sickness in humans and cattle.

    PubMed

    Ndondo, A M; Munganga, J M W; Mwambakana, J N; Saad-Roy, C M; van den Driessche, P; Walo, R O

    2016-01-01

    Human African Trypanosomiasis (HAT) and Nagana in cattle, commonly called sleeping sickness, is caused by trypanosome protozoa transmitted by bites of infected tsetse flies. We present a deterministic model for the transmission of HAT caused by Trypanosoma brucei gambiense between human hosts, cattle hosts and tsetse flies. The model takes into account the growth of the tsetse fly, from its larval stage to the adult stage. Disease in the tsetse fly population is modeled by three compartments, and both the human and cattle populations are modeled by four compartments incorporating the two stages of HAT. We provide a rigorous derivation of the basic reproduction number R0. For R0 < 1, the disease free equilibrium is globally asymptotically stable, thus HAT dies out; whereas (assuming no return to susceptibility) for R0 >1, HAT persists. Elasticity indices for R0 with respect to different parameters are calculated with baseline parameter values appropriate for HAT in West Africa; indicating parameters that are important for control strategies to bring R0 below 1. Numerical simulations with R0 > 1 show values for the infected populations at the endemic equilibrium, and indicate that with certain parameter values, HAT could not persist in the human population in the absence of cattle. PMID:27296784

  6. Demonstration of Wavelet Techniques in the Spectral Analysis of Bypass Transition Data

    NASA Technical Reports Server (NTRS)

    Lewalle, Jacques; Ashpis, David E.; Sohn, Ki-Hyeon

    1997-01-01

    A number of wavelet-based techniques for the analysis of experimental data are developed and illustrated. A multiscale analysis based on the Mexican hat wavelet is demonstrated as a tool for acquiring physical and quantitative information not obtainable by standard signal analysis methods. Experimental data for the analysis came from simultaneous hot-wire velocity traces in a bypass transition of the boundary layer on a heated flat plate. A pair of traces (two components of velocity) at one location was excerpted. A number of ensemble and conditional statistics related to dominant time scales for energy and momentum transport were calculated. The analysis revealed a lack of energy-dominant time scales inside turbulent spots but identified transport-dominant scales inside spots that account for the largest part of the Reynolds stress. Momentum transport was much more intermittent than were energetic fluctuations. This work is the first step in a continuing study of the spatial evolution of these scale-related statistics, the goal being to apply the multiscale analysis results to improve the modeling of transitional and turbulent industrial flows.

  7. Simulation of springback and microstructural analysis of dual phase steels

    NASA Astrophysics Data System (ADS)

    Kalyan, T. Sri.; Wei, Xing; Mendiguren, Joseba; Rolfe, Bernard

    2013-12-01

    With increasing demand for weight reduction and better crashworthiness abilities in car development, advanced high strength Dual Phase (DP) steels have been progressively used when making automotive parts. The higher strength steels exhibit higher springback and lower dimensional accuracy after stamping. This has necessitated the use of simulation of each stamped component prior to production to estimate the part's dimensional accuracy. Understanding the micro-mechanical behaviour of AHSS sheet may provide more accuracy to stamping simulations. This work can be divided basically into two parts: first modelling a standard channel forming process; second modelling the micro-structure of the process. The standard top hat channel forming process, benchmark NUMISHEET'93, is used for investigating springback effect of WISCO Dual Phase steels. The second part of this work includes the finite element analysis of microstructures to understand the behaviour of the multi-phase steel at a more fundamental level. The outcomes of this work will help in the dimensional control of steels during manufacturing stage based on the material's microstructure.

  8. Study on photochemical analysis system (VLES) for EUV lithography

    NASA Astrophysics Data System (ADS)

    Sekiguchi, A.; Kono, Y.; Kadoi, M.; Minami, Y.; Kozawa, T.; Tagawa, S.; Gustafson, D.; Blackborow, P.

    2007-03-01

    A system for photo-chemical analysis of EUV lithography processes has been developed. This system has consists of 3 units: (1) an exposure that uses the Z-Pinch (Energetiq Tech.) EUV Light source (DPP) to carry out a flood exposure, (2) a measurement system RDA (Litho Tech Japan) for the development rate of photo-resists, and (3) a simulation unit that utilizes PROLITH (KLA-Tencor) to calculate the resist profiles and process latitude using the measured development rate data. With this system, preliminary evaluation of the performance of EUV lithography can be performed without any lithography tool (Stepper and Scanner system) that is capable of imaging and alignment. Profiles for 32 nm line and space pattern are simulated for the EUV resist (Posi-2 resist by TOK) by using VLES that hat has sensitivity at the 13.5nm wavelength. The simulation successfully predicts the resist behavior. Thus it is confirmed that the system enables efficient evaluation of the performance of EUV lithography processes.

  9. Some efficient methods for obtaining infinite series solutions of n-th order linear ordinary differential equations

    NASA Technical Reports Server (NTRS)

    Allen, G.

    1972-01-01

    The use of the theta-operator method and generalized hypergeometric functions in obtaining solutions to nth-order linear ordinary differential equations is explained. For completeness, the analysis of the differential equation to determine whether the point of expansion is an ordinary point or a regular singular point is included. The superiority of the two methods shown over the standard method is demonstrated by using all three of the methods to work out several examples. Also included is a compendium of formulae and properties of the theta operator and generalized hypergeometric functions which is complete enough to make the report self-contained.

  10. The JASMIN Analysis Platform - bridging the gap between traditional climate data practicies and data-centric analysis paradigms

    NASA Astrophysics Data System (ADS)

    Pascoe, Stephen; Iwi, Alan; kershaw, philip; Stephens, Ag; Lawrence, Bryan

    2014-05-01

    The advent of large-scale data and the consequential analysis problems have led to two new challenges for the research community: how to share such data to get the maximum value and how to carry out efficient analysis. Solving both challenges require a form of parallelisation: the first is social parallelisation (involving trust and information sharing), the second data parallelisation (involving new algorithms and tools). The JASMIN infrastructure supports both kinds of parallelism by providing a multi-tennent environment with petabyte-scale storage, VM provisioning and batch cluster facilities. The JASMIN Analysis Platform (JAP) is an analysis software layer for JASMIN which emphasises ease of transition from a researcher's local environment to JASMIN. JAP brings together tools traditionally used by multiple communities and configures them to work together, enabling users to move analysis from their local environment to JASMIN without rewriting code. JAP also provides facilities to exploit JASMIN's parallel capabilities whilst maintaining their familiar analysis environment where ever possible. Modern opensource analysis tools typically have multiple dependent packages, increasing the installation burden on system administrators. When you consider a suite of tools, often with both common and conflicting dependencies, analysis pipelines can become locked to a particular installation simply because of the effort required to reconstruct the dependency tree. JAP addresses this problem by providing a consistent suite of RPMs compatible with RedHat Enterprise Linux and CentOS 6.4. Researchers can install JAP locally, either as RPMs or through a pre-built VM image, giving them the confidence to know moving analysis to JASMIN will not disrupt their environment. Analysis parallelisation is in it's infancy in climate sciences, with few tools capable of exploiting any parallel environment beyond manual scripting of the use of multiple processors. JAP begins to bridge this

  11. Influence of water content on the laser-induced breakdown spectroscopy analysis of human cell pellet

    NASA Astrophysics Data System (ADS)

    Moon, Youngmin; Han, Jung Hyun; Lee, Jong Jin; Jeong, Sungho

    2015-12-01

    The effects of water content change in a biological sample on the emission signal intensity and intensity ratio during LIBS analysis were investigated. To examine the effects of water content only avoiding matrix effects, a homogeneous human cell pellet consisting of cultured human immortalized keratinocyte cell only was used as the sample. LIBS spectra of the human cell pellet sample produced with a Q-switched Nd:YAG laser (λ = 532 nm, τ = 5 ns, top-hat profile) and a six-channel CCD spectrometer (spectral range = 187-1045 nm, spectral resolution = 0.1 nm) revealed that most of the emission lines observed from a tissue sample were also observable from the human cell pellet. The intensity and intensity ratio of the emission lines varied significantly as the water content of the human cell pellet was changed. It was found that a typically selected internal standard in LIBS analysis of biological samples such as carbon could produce inconsistent results, whereas the ratio of properly selected emission lines such as Mg(II) 280.270 nm and Ca(II) 396.847 nm was nearly independent of sample water content.

  12. INTRODUCING MEXICAN NEEDLETS FOR CMB ANALYSIS: ISSUES FOR PRACTICAL APPLICATIONS AND COMPARISON WITH STANDARD NEEDLETS

    SciTech Connect

    Scodeller, S.; Rudjord, Oe.; Hansen, F. K.; Marinucci, D.; Geller, D.; Mayeli, A.

    2011-06-01

    Over the last few years, needlets have emerged as a useful tool for the analysis of cosmic microwave background (CMB) data. Our aim in this paper is first to introduce into the CMB literature a different form of needlets, known as Mexican needlets, first discussed in the mathematical literature by Geller and Mayeli. We then proceed with an extensive study of the properties of both standard and Mexican needlets; these properties depend on some parameters which can be tuned in order to optimize the performance for a given application. Our second aim in this paper is then to give practical advice on how to adjust these parameters for WMAP and Planck data in order to achieve the best properties for a given problem in CMB data analysis. In particular, we investigate localization properties in real and harmonic space and propose a recipe for quantifying the influence of galactic and point-source masks on the needlet coefficients. We also show that for certain parameter values, the Mexican needlets provide a close approximation to the Spherical Mexican Hat Wavelets (whence their name), with some advantages concerning their numerical implementation and derivation of their statistical properties.

  13. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands

    PubMed Central

    Lubula, Mulu Y.; Poplawaski, Amanda; Glass, Karen C.

    2014-01-01

    The bromodomain-PHD finger protein 1 (BRPF1) is an essential subunit of the monocytic leukemia zinc (MOZ) histone acetyltransferase (HAT) complex and is required for complex formation and enzymatic activation. BRPF1 contains a structurally conserved bromodomain, which recognizes specific acetyllysine residues on histone proteins. The MOZ HAT plays a direct role in hematopoiesis, and deregulation of its activity is linked to the development of acute myeloid leukemia. However, the molecular mechanism of histone-ligand recognition by the BRPF1 bromodomain is currently unknown. The 117-amino-acid BRPF1 bromodomain was overexpressed in Escherichia coli and purified to homogeneity. Crystallization experiments of the BRPF1 bromodomain in complex with its H4K12ac and H2AK5ac histone ligands yielded crystals that were suitable for high-resolution X-ray diffraction analysis. The BRPF1 bromodomain–H4K12ac crystals belonged to the tetragonal space group P43212, with unit-cell parameters a = 75.1, b = 75.1, c = 86.3 Å, and diffracted to a resolution of 1.94 Å. The BRPF1 bromodomain–H2AK5ac crystals grew in the monoclinic space group P21, with unit-cell parameters a = 60.9, b = 55.6, c = 82.1 Å, β = 93.6°, and diffracted to a resolution of 1.80 Å. Complete data sets were collected from both crystal forms using synchrotron radiation on beamline X29 at Brookhaven National Laboratory (BNL). PMID:25286946

  14. Spatial Predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) Prevalence in Kaberamaido and Dokolo, Two Newly Affected Districts of Uganda

    PubMed Central

    Batchelor, Nicola A.; Atkinson, Peter M.; Gething, Peter W.; Picozzi, Kim; Fèvre, Eric M.; Kakembo, Abbas S. L.; Welburn, Susan C.

    2009-01-01

    The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda. PMID:20016846

  15. Efficient Design and Analysis of Lightweight Reinforced Core Sandwich and PRSEUS Structures

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Yarrington, Phillip W.; Lucking, Ryan C.; Collier, Craig S.; Ainsworth, James J.; Toubia, Elias A.

    2012-01-01

    Design, analysis, and sizing methods for two novel structural panel concepts have been developed and incorporated into the HyperSizer Structural Sizing Software. Reinforced Core Sandwich (RCS) panels consist of a foam core with reinforcing composite webs connecting composite facesheets. Boeing s Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) panels use a pultruded unidirectional composite rod to provide axial stiffness along with integrated transverse frames and stitching. Both of these structural concepts are ovencured and have shown great promise applications in lightweight structures, but have suffered from the lack of efficient sizing capabilities similar to those that exist for honeycomb sandwich, foam sandwich, hat stiffened, and other, more traditional concepts. Now, with accurate design methods for RCS and PRSEUS panels available in HyperSizer, these concepts can be traded and used in designs as is done with the more traditional structural concepts. The methods developed to enable sizing of RCS and PRSEUS are outlined, as are results showing the validity and utility of the methods. Applications include several large NASA heavy lift launch vehicle structures.

  16. Predicting the aquatic toxicity mode of action using logistic regression and linear discriminant analysis.

    PubMed

    Ren, Y Y; Zhou, L C; Yang, L; Liu, P Y; Zhao, B W; Liu, H X

    2016-09-01

    The paper highlights the use of the logistic regression (LR) method in the construction of acceptable statistically significant, robust and predictive models for the classification of chemicals according to their aquatic toxic modes of action. Essentials accounting for a reliable model were all considered carefully. The model predictors were selected by stepwise forward discriminant analysis (LDA) from a combined pool of experimental data and chemical structure-based descriptors calculated by the CODESSA and DRAGON software packages. Model predictive ability was validated both internally and externally. The applicability domain was checked by the leverage approach to verify prediction reliability. The obtained models are simple and easy to interpret. In general, LR performs much better than LDA and seems to be more attractive for the prediction of the more toxic compounds, i.e. compounds that exhibit excess toxicity versus non-polar narcotic compounds and more reactive compounds versus less reactive compounds. In addition, model fit and regression diagnostics was done through the influence plot which reflects the hat-values, studentized residuals, and Cook's distance statistics of each sample. Overdispersion was also checked for the LR model. The relationships between the descriptors and the aquatic toxic behaviour of compounds are also discussed. PMID:27653817

  17. Transcriptome analysis of the mammary gland from GH transgenic goats during involution.

    PubMed

    Lin, Jian; Bao, Ze Kun; Zhang, Qiang; Hu, Wei Wei; Yu, Qing Hua; Yang, Qian

    2015-07-10

    Mammary glands are organs for milk production in female mammals. Growth hormone (GH) is known to affect the growth and development of the mammary gland, as well as to increase milk production in dairy goats. This study performed a comprehensive expression profiling of genes expressed in the mammary gland of early involution GH transgenic (n=4) and non-transgenic goats (n=4) by RNA sequencing. RNA was extracted from mammary gland tissues collected at day 3 of involution. Gene expression analysis was conducted by Illumina RNA sequencing and sequence reads were assembled and analyzed using TopHat. FPKM (fragments per kilobase of exon per million) values were analyzed for differentially expressed genes using the Cufflinks package. Gene ontology analysis of differentially expressed genes was categorized using agriGO, while KEGG pathway analysis was performed with the online KEGG automatic annotation server. Our results revealed that 75% of NCBI goat annotated genes were expressed during early involution. A total of 18,323 genes were expressed during early involution in GH transgenic goats, compared with 18,196 expressed genes during early involution of non-transgenic goats. In these expressed genes, the majority (17,589) were ubiquitously expressed in GH transgenic and non-transgenic goats. However, there were 745 differentially expressed genes, 421 of which were upregulated and 324 were downregulated in GH transgenic goats. GO and KEGG pathway analysis showed that these genes were involved in mammary gland physiology, including cell adhesion molecules, ECM-receptor interaction, Jak-STAT signaling pathway, and fat metabolism. Our results demonstrated that the GH receptor was strongly affected in GH transgenic goats, which may activate the IGF-1/Stat3 signaling pathway. Overall, our study provided a global view of the transcriptome during involution of GH transgenic and non-transgenic goats, which increases our understanding of the biology of involution in the goat.

  18. Lu-Hf Analysis of Zircons in the Little Belt Mountains Suggest Paleoproterozoic Subduction in the Great Falls Tectonic Zone

    NASA Astrophysics Data System (ADS)

    Weiss, R. A.; Vogl, J. J.; Mueller, P. A.; Foster, D. A.; Kamenov, G. D.; Wooden, J. L.

    2009-12-01

    In the assembly of Southwestern Laurentia two competing regions have been proposed as the location of a Paleoproterozoic suture between the Archean Wyoming and Hearne provinces; either the Vulcan Structure, located between the Hearne Province and the Medicine Hat Block, or the Great Falls tectonic zone (GFTZ) between the Medicine Hat Block and the Wyoming Province. Due to a general lack of Precambrian exposure in these areas, discerning the true location of the collision has proven challenging, though mounting evidence indicates the GFTZ as the site for this suture. Among this evidence is a Sm-Nd model age of 1.9 Ga for the Little Belt Mountains of the Eastern GFTZ. Samples collected from across multiple units in the Little Belt Mountains have undergone Lu-Hf analysis on individual zircons using laser ablation, MC-ICP-MS. Among these units the Helispot Granite is a recrystallized granite to granodiorite that locally contains strongly foliated, recrystallized porphyroclastic mylonitic textures and has a mean Lu-Hf model age of 1.99 Ga (TDM) with a range of 1.92-2.17 Ga as well as a U-Pb age of 1842 ± 42 Ma. The Cemetery Migmatite is locally banded and derived from igneous components of varied composition with a mean Lu-Hf age of 2.02 Ga (TDM) and a range of 1.85-2.14 Ga as well as a U-Pb age of 1817 ± 16 Ma. The Hoover Ridge Unit is a diverse collection of felsic to mafic intrusives with a mean Lu-Hf age of 2.63 Ga and a range of 2.54-2.88 Ga (TDM) in addition to a U-Pb age of 1846 ± 9 Ma. The Aspen Paragneiss, a migmatitic pelitic paragneiss with local melt layers and injections, has a Lu-Hf age of 2.77 Ga with a range of 2.53-3.19 Ga (TDM). The O’Brien Creek Unit contains fine grained granitic rocks with a mean Lu-Hf model age of 2.21 Ga ranged between 1.59-2.5 Ga (TDM) and a U-Pb age of 1800-1820 Ma. The Sheep Creek Complex contains a collection of granitoids including a sheeted, garnet bearing leucogranite as well as abundant amphibolites. This unit has a

  19. SMOOTHNESS OF GENERALIZED SOLUTIONS OF THE EQUATION \\hat Hu=f AND ESSENTIAL SELFADJOINTNESS OF THE OPERATOR \\hat H=-\\sum_{i,j}\

    NASA Astrophysics Data System (ADS)

    Semenov, Yu A.

    1986-02-01

    Certain aspects of the theory of second order elliptic partial differential operators are considered: (L^p,\\,L^q)-estimates for powers of the resolvents, and the integralness and smoothness of certain linear spaces generated by solutions of such equations. Applications are given to the first spectral question. One of the main results is global criteria for essential selfadjointness in the presence of simultaneous growth at infinity of the coefficients determining the equation.Bibliography: 21 titles.

  20. A feasibility assessment of automated FISH image and signal analysis to assist cervical cancer detection

    NASA Astrophysics Data System (ADS)

    Wang, Xingwei; Li, Yuhua; Liu, Hong; Li, Shibo; Zhang, Roy R.; Zheng, Bin

    2012-02-01

    Fluorescence in situ hybridization (FISH) technology provides a promising molecular imaging tool to detect cervical cancer. Since manual FISH analysis is difficult, time-consuming, and inconsistent, the automated FISH image scanning systems have been developed. Due to limited focal depth of scanned microscopic image, a FISH-probed specimen needs to be scanned in multiple layers that generate huge image data. To improve diagnostic efficiency of using automated FISH image analysis, we developed a computer-aided detection (CAD) scheme. In this experiment, four pap-smear specimen slides were scanned by a dual-detector fluorescence image scanning system that acquired two spectrum images simultaneously, which represent images of interphase cells and FISH-probed chromosome X. During image scanning, once detecting a cell signal, system captured nine image slides by automatically adjusting optical focus. Based on the sharpness index and maximum intensity measurement, cells and FISH signals distributed in 3-D space were projected into a 2-D con-focal image. CAD scheme was applied to each con-focal image to detect analyzable interphase cells using an adaptive multiple-threshold algorithm and detect FISH-probed signals using a top-hat transform. The ratio of abnormal cells was calculated to detect positive cases. In four scanned specimen slides, CAD generated 1676 con-focal images that depicted analyzable cells. FISH-probed signals were independently detected by our CAD algorithm and an observer. The Kappa coefficients for agreement between CAD and observer ranged from 0.69 to 1.0 in detecting/counting FISH signal spots. The study demonstrated the feasibility of applying automated FISH image and signal analysis to assist cyto-geneticists in detecting cervical cancers.

  1. A new data compression method and its application to cosmic shear analysis

    NASA Astrophysics Data System (ADS)

    Asgari, Marika; Schneider, Peter

    2015-06-01

    Context. Future large scale cosmological surveys will provide huge data sets whose analysis requires efficient data compression. In particular, the calculation of accurate covariances is extremely challenging with an increasing number of observables used in the statistical analysis. Aims: The primary aim of this paper is to introduce a formalism for achieving efficient data compression, based on a local expansion of the observables around a fiducial cosmological model. We specifically apply and test this approach for the case of cosmic shear statistics. In addition, we study how well band powers can be obtained from measuring shear correlation functions over a finite interval of separations. Methods: We demonstrate the performance of our approach, using a Fisher analysis on cosmic shear tomography described in terms of E-/B-mode separating statistics (COSEBIs). Results: We show that our data compression is highly effective in extracting essentially the full cosmological information from a strongly reduced number of observables. Specifically, the number of observables needed decreases by at least one order of magnitude relative to the COSEBIs, which already compress the data substantially compared to the shear two-point correlation functions. The efficiency appears to be affected only slightly if a highly inaccurate covariance is used for defining the compressed data vector, showing the robustness of the method. In addition, we show the strong limitations on the possibility of constructing top-hat filters in Fourier space, for which the real-space analog has a finite support, yielding strong bounds on the accuracy of band power estimates. Conclusions: We conclude that efficient data compression is achievable and that the number of compressed data points depends on the number of model parameters. Furthermore, a band convergence power spectrum inferred from a finite angular range cannot be accurately estimated. The error on an estimated band power is larger for a

  2. Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy

    PubMed Central

    Moraes, Lucia M; Cardoso, Leila CA; Moura, Vera LS; Moreira, Miguel AM; Menezes, Albert N; Llerena, Juan C; Seuánez, Héctor N

    2009-01-01

    Background Pentasomy X (49,XXXXX) has been associated with a severe clinical condition, presumably resulting from failure or disruption of X chromosome inactivation. Here we report that some human X chromosomes from a patient with 49,XXXXX pentasomy were functionally active following isolation in inter-specific (human-rodent) cell hybrids. A comparison with cytogenetic and molecular findings provided evidence that more than one active X chromosome was likely to be present in the cells of this patient, accounting for her abnormal phenotype. Results 5-bromodeoxyuridine (BrdU)-pulsed cultures showed different patterns among late replicating X chromosomes suggesting that their replication was asynchronic and likely to result in irregular inactivation. Genotyping of the proband and her mother identified four maternal and one paternal X chromosomes in the proband. It also identified the paternal X chromosome haplotype (P), indicating that origin of this X pentasomy resulted from two maternal, meiotic non-disjunctions. Analysis of the HUMANDREC region of the androgen receptor (AR) gene in the patient's mother showed a skewed inactivation pattern, while a similar analysis in the proband showed an active paternal X chromosome and preferentially inactivated X chromosomes carrying the 173 AR allele. Analyses of 33 cell hybrid cell lines selected in medium containing hypoxanthine, aminopterin and thymidine (HAT) allowed for the identification of three maternal X haplotypes (M1, M2 and MR) and showed that X chromosomes with the M1, M2 and P haplotypes were functionally active. In 27 cell hybrids in which more than one X haplotype were detected, analysis of X inactivation patterns provided evidence of preferential inactivation. Conclusion Our findings indicated that 12% of X chromosomes with the M1 haplotype, 43.5% of X chromosomes with the M2 haplotype, and 100% of the paternal X chromosome (with the P haplotype) were likely to be functionally active in the proband's cells, a

  3. Asymptotics of large deviations of Gaussian processes of Wiener type for L^p-functionals, p>0, and the hypergeometric function

    NASA Astrophysics Data System (ADS)

    Fatalov, V. R.

    2003-04-01

    A general result is obtained on exact asymptotics of the probabilities \\displaystyle \\mathsf P\\biggl\\{\\int_0^1\\vert\\xi(t)\\vert^p\\,dt>u^p\\biggr\\}as u\\to\\infty and p>0 for Gaussian processes \\xi(t).The general theorem is applied for the calculation of these asymptotics in the cases of the following processes: the Wiener process w(t), the Brownian bridge, and the stationary Gaussian process \\eta(t):=w(t+1)-w(t), t\\in\\mathbb R^1.The Laplace method in Banach spaces is used. The calculations of the constants reduce to solving an extremum problem for the action functional and studying the spectrum of a differential operator of the second order of Sturm-Liouville type.

  4. Thermal analysis

    SciTech Connect

    Wunderlich, B. )

    1990-01-01

    This book presents the basic theory and techniques of thermal analysis. It discusses a range of applications and instrumentation from all fields of applied and basic research, and concludes with problem sets. Topics covered include: The Basics of Thermal Analysis; Thermometry; Differential Thermal Analysis; Calorimetry; Thermomechanical Analysis and Dilatometry; and Thermogravimetry.

  5. Large-scale automated image analysis for computational profiling of brain tissue surrounding implanted neuroprosthetic devices using Python

    PubMed Central

    Rey-Villamizar, Nicolas; Somasundar, Vinay; Megjhani, Murad; Xu, Yan; Lu, Yanbin; Padmanabhan, Raghav; Trett, Kristen; Shain, William; Roysam, Badri

    2014-01-01

    In this article, we describe the use of Python for large-scale automated server-based bio-image analysis in FARSIGHT, a free and open-source toolkit of image analysis methods for quantitative studies of complex and dynamic tissue microenvironments imaged by modern optical microscopes, including confocal, multi-spectral, multi-photon, and time-lapse systems. The core FARSIGHT modules for image segmentation, feature extraction, tracking, and machine learning are written in C++, leveraging widely used libraries including ITK, VTK, Boost, and Qt. For solving complex image analysis tasks, these modules must be combined into scripts using Python. As a concrete example, we consider the problem of analyzing 3-D multi-spectral images of brain tissue surrounding implanted neuroprosthetic devices, acquired using high-throughput multi-spectral spinning disk step-and-repeat confocal microscopy. The resulting images typically contain 5 fluorescent channels. Each channel consists of 6000 × 10,000 × 500 voxels with 16 bits/voxel, implying image sizes exceeding 250 GB. These images must be mosaicked, pre-processed to overcome imaging artifacts, and segmented to enable cellular-scale feature extraction. The features are used to identify cell types, and perform large-scale analysis for identifying spatial distributions of specific cell types relative to the device. Python was used to build a server-based script (Dell 910 PowerEdge servers with 4 sockets/server with 10 cores each, 2 threads per core and 1TB of RAM running on Red Hat Enterprise Linux linked to a RAID 5 SAN) capable of routinely handling image datasets at this scale and performing all these processing steps in a collaborative multi-user multi-platform environment. Our Python script enables efficient data storage and movement between computers and storage servers, logs all the processing steps, and performs full multi-threaded execution of all codes, including open and closed-source third party libraries. PMID:24808857

  6. Large-scale automated image analysis for computational profiling of brain tissue surrounding implanted neuroprosthetic devices using Python.

    PubMed

    Rey-Villamizar, Nicolas; Somasundar, Vinay; Megjhani, Murad; Xu, Yan; Lu, Yanbin; Padmanabhan, Raghav; Trett, Kristen; Shain, William; Roysam, Badri

    2014-01-01

    In this article, we describe the use of Python for large-scale automated server-based bio-image analysis in FARSIGHT, a free and open-source toolkit of image analysis methods for quantitative studies of complex and dynamic tissue microenvironments imaged by modern optical microscopes, including confocal, multi-spectral, multi-photon, and time-lapse systems. The core FARSIGHT modules for image segmentation, feature extraction, tracking, and machine learning are written in C++, leveraging widely used libraries including ITK, VTK, Boost, and Qt. For solving complex image analysis tasks, these modules must be combined into scripts using Python. As a concrete example, we consider the problem of analyzing 3-D multi-spectral images of brain tissue surrounding implanted neuroprosthetic devices, acquired using high-throughput multi-spectral spinning disk step-and-repeat confocal microscopy. The resulting images typically contain 5 fluorescent channels. Each channel consists of 6000 × 10,000 × 500 voxels with 16 bits/voxel, implying image sizes exceeding 250 GB. These images must be mosaicked, pre-processed to overcome imaging artifacts, and segmented to enable cellular-scale feature extraction. The features are used to identify cell types, and perform large-scale analysis for identifying spatial distributions of specific cell types relative to the device. Python was used to build a server-based script (Dell 910 PowerEdge servers with 4 sockets/server with 10 cores each, 2 threads per core and 1TB of RAM running on Red Hat Enterprise Linux linked to a RAID 5 SAN) capable of routinely handling image datasets at this scale and performing all these processing steps in a collaborative multi-user multi-platform environment. Our Python script enables efficient data storage and movement between computers and storage servers, logs all the processing steps, and performs full multi-threaded execution of all codes, including open and closed-source third party libraries.

  7. Large-scale automated image analysis for computational profiling of brain tissue surrounding implanted neuroprosthetic devices using Python.

    PubMed

    Rey-Villamizar, Nicolas; Somasundar, Vinay; Megjhani, Murad; Xu, Yan; Lu, Yanbin; Padmanabhan, Raghav; Trett, Kristen; Shain, William; Roysam, Badri

    2014-01-01

    In this article, we describe the use of Python for large-scale automated server-based bio-image analysis in FARSIGHT, a free and open-source toolkit of image analysis methods for quantitative studies of complex and dynamic tissue microenvironments imaged by modern optical microscopes, including confocal, multi-spectral, multi-photon, and time-lapse systems. The core FARSIGHT modules for image segmentation, feature extraction, tracking, and machine learning are written in C++, leveraging widely used libraries including ITK, VTK, Boost, and Qt. For solving complex image analysis tasks, these modules must be combined into scripts using Python. As a concrete example, we consider the problem of analyzing 3-D multi-spectral images of brain tissue surrounding implanted neuroprosthetic devices, acquired using high-throughput multi-spectral spinning disk step-and-repeat confocal microscopy. The resulting images typically contain 5 fluorescent channels. Each channel consists of 6000 × 10,000 × 500 voxels with 16 bits/voxel, implying image sizes exceeding 250 GB. These images must be mosaicked, pre-processed to overcome imaging artifacts, and segmented to enable cellular-scale feature extraction. The features are used to identify cell types, and perform large-scale analysis for identifying spatial distributions of specific cell types relative to the device. Python was used to build a server-based script (Dell 910 PowerEdge servers with 4 sockets/server with 10 cores each, 2 threads per core and 1TB of RAM running on Red Hat Enterprise Linux linked to a RAID 5 SAN) capable of routinely handling image datasets at this scale and performing all these processing steps in a collaborative multi-user multi-platform environment. Our Python script enables efficient data storage and movement between computers and storage servers, logs all the processing steps, and performs full multi-threaded execution of all codes, including open and closed-source third party libraries. PMID:24808857

  8. Spin-Orbit Alignment of Exoplanet Systems: Ensemble Analysis Using Asteroseismology

    NASA Astrophysics Data System (ADS)

    Campante, T. L.; Lund, M. N.; Kuszlewicz, J. S.; Davies, G. R.; Chaplin, W. J.; Albrecht, S.; Winn, J. N.; Bedding, T. R.; Benomar, O.; Bossini, D.; Handberg, R.; Santos, A. R. G.; Van Eylen, V.; Basu, S.; Christensen-Dalsgaard, J.; Elsworth, Y. P.; Hekker, S.; Hirano, T.; Huber, D.; Karoff, C.; Kjeldsen, H.; Lundkvist, M. S.; North, T. S. H.; Silva Aguirre, V.; Stello, D.; White, T. R.

    2016-03-01

    The angle ψ between a planet’s orbital axis and the spin axis of its parent star is an important diagnostic of planet formation, migration, and tidal evolution. We seek empirical constraints on ψ by measuring the stellar inclination is via asteroseismology for an ensemble of 25 solar-type hosts observed with NASA’s Kepler satellite. Our results for is are consistent with alignment at the 2σ level for all stars in the sample, meaning that the system surrounding the red-giant star Kepler-56 remains as the only unambiguous misaligned multiple-planet system detected to date. The availability of a measurement of the projected spin-orbit angle λ for two of the systems allows us to estimate ψ. We find that the orbit of the hot Jupiter HAT-P-7b is likely to be retrograde (\\psi =116\\buildrel{\\circ}\\over{.} {4}-14.7+30.2), whereas that of Kepler-25c seems to be well aligned with the stellar spin axis (\\psi =12\\buildrel{\\circ}\\over{.} {6}-11.0+6.7). While the latter result is in apparent contradiction with a statement made previously in the literature that the multi-transiting system Kepler-25 is misaligned, we show that the results are consistent, given the large associated uncertainties. Finally, we perform a hierarchical Bayesian analysis based on the asteroseismic sample in order to recover the underlying distribution of ψ. The ensemble analysis suggests that the directions of the stellar spin and planetary orbital axes are correlated, as conveyed by a tendency of the host stars to display large values of inclination.

  9. A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae

    PubMed Central

    Nookaew, Intawat; Papini, Marta; Pornputtapong, Natapol; Scalcinati, Gionata; Fagerberg, Linn; Uhlén, Matthias; Nielsen, Jens

    2012-01-01

    RNA-seq, has recently become an attractive method of choice in the studies of transcriptomes, promising several advantages compared with microarrays. In this study, we sought to assess the contribution of the different analytical steps involved in the analysis of RNA-seq data generated with the Illumina platform, and to perform a cross-platform comparison based on the results obtained through Affymetrix microarray. As a case study for our work we, used the Saccharomyces cerevisiae strain CEN.PK 113-7D, grown under two different conditions (batch and chemostat). Here, we asses the influence of genetic variation on the estimation of gene expression level using three different aligners for read-mapping (Gsnap, Stampy and TopHat) on S288c genome, the capabilities of five different statistical methods to detect differential gene expression (baySeq, Cuffdiff, DESeq, edgeR and NOISeq) and we explored the consistency between RNA-seq analysis using reference genome and de novo assembly approach. High reproducibility among biological replicates (correlation ≥0.99) and high consistency between the two platforms for analysis of gene expression levels (correlation ≥0.91) are reported. The results from differential gene expression identification derived from the different statistical methods, as well as their integrated analysis results based on gene ontology annotation are in good agreement. Overall, our study provides a useful and comprehensive comparison between the two platforms (RNA-seq and microrrays) for gene expression analysis and addresses the contribution of the different steps involved in the analysis of RNA-seq data. PMID:22965124

  10. Fractional wavelet analysis for the simultaneous quantitative analysis of lacidipine and its photodegradation product by continuous wavelet transform and multilinear regression calibration.

    PubMed

    Dinç, Erdal; Ragno, Gaetano; Ioele, Giuseppina; Baleanu, Dumitru

    2006-01-01

    Fractional wavelet transform (FWT) was applied to the original absorption spectra of lacidipine (LAC) and its photodegradation product (LACD), and the resulting FWT spectra were processed by continuous wavelet transform (CWT) and multilinear regression calibration (MLRC) for the simultaneous quantitative analysis of both products in their binary mixtures. These methods do not require any chemical separation step and chemical complex reaction to obtain a detectable signal for the degradation product. By using the Mexican hat function, 2 calibration functions for LAC and LACD were obtained by measuring the CWT transformed signals at 416.1 nm for LAC and 414.6 nm for LACD, after FWT processing of the original absorption spectra. The calibration graphs were linear in the concentration range of 5.08-40.64 microg/mL for LAC and 0.51-8.16 microg/mL for LACD. The limit of detection and the limit of quantitation were found to be 0.289 and 0.956 microg/mL for LAC and 0.036 and 0.118 microg/mL for LACD, respectively. For comparison, the MLRC algorithm was applied to the linear regression functions for the individual drug and its photoproduct. In this approach, a set of linear regression functions was obtained from the relationship between concentrations and FWT signals in the wavelength range 411.0-412.4 nm. Both methods were applied to the quantitative evaluation of LAC and LACD in laboratory and pharmaceutical samples, and produced very satisfactory results.

  11. Genome-Wide Comparative Analysis of 20 Miniature Inverted-Repeat Transposable Element Families in Brassica rapa and B. oleracea

    PubMed Central

    Sampath, Perumal; Murukarthick, Jayakodi; Izzah, Nur Kholilatul; Lee, Jonghoon; Choi, Hong-Il; Shirasawa, Kenta; Choi, Beom-Soon; Liu, Shengyi; Nou, Ill-Sup; Yang, Tae-Jin

    2014-01-01

    Miniature inverted-repeat transposable elements (MITEs) are ubiquitous, non-autonomous class II transposable elements. Here, we conducted genome-wide comparative analysis of 20 MITE families in B. rapa, B. oleracea, and Arabidopsis thaliana. A total of 5894 and 6026 MITE members belonging to the 20 families were found in the whole genome pseudo-chromosome sequences of B. rapa and B. oleracea, respectively. Meanwhile, only four of the 20 families, comprising 573 members, were identified in the Arabidopsis genome, indicating that most of the families were activated in the Brassica genus after divergence from Arabidopsis. Copy numbers varied from 4 to 1459 for each MITE family, and there was up to 6-fold variation between B. rapa and B. oleracea. In particular, analysis of intact members showed that whereas eleven families were present in similar copy numbers in B. rapa and B. oleracea, nine families showed copy number variation ranging from 2- to 16-fold. Four of those families (BraSto-3, BraTo-3, 4, 5) were more abundant in B. rapa, and the other five (BraSto-1, BraSto-4, BraTo-1, 7 and BraHAT-1) were more abundant in B. oleracea. Overall, 54% and 51% of the MITEs resided in or within 2 kb of a gene in the B. rapa and B. oleracea genomes, respectively. Notably, 92 MITEs were found within the CDS of annotated genes, suggesting that MITEs might play roles in diversification of genes in the recently triplicated Brassica genome. MITE insertion polymorphism (MIP) analysis of 289 MITE members showed that 52% and 23% were polymorphic at the inter- and intra-species levels, respectively, indicating that there has been recent MITE activity in the Brassica genome. These recently activated MITE families with abundant MIP will provide useful resources for molecular breeding and identification of novel functional genes arising from MITE insertion. PMID:24747717

  12. Genome-wide comparative analysis of 20 miniature inverted-repeat transposable element families in Brassica rapa and B. oleracea.

    PubMed

    Sampath, Perumal; Murukarthick, Jayakodi; Izzah, Nur Kholilatul; Lee, Jonghoon; Choi, Hong-Il; Shirasawa, Kenta; Choi, Beom-Soon; Liu, Shengyi; Nou, Ill-Sup; Yang, Tae-Jin

    2014-01-01

    Miniature inverted-repeat transposable elements (MITEs) are ubiquitous, non-autonomous class II transposable elements. Here, we conducted genome-wide comparative analysis of 20 MITE families in B. rapa, B. oleracea, and Arabidopsis thaliana. A total of 5894 and 6026 MITE members belonging to the 20 families were found in the whole genome pseudo-chromosome sequences of B. rapa and B. oleracea, respectively. Meanwhile, only four of the 20 families, comprising 573 members, were identified in the Arabidopsis genome, indicating that most of the families were activated in the Brassica genus after divergence from Arabidopsis. Copy numbers varied from 4 to 1459 for each MITE family, and there was up to 6-fold variation between B. rapa and B. oleracea. In particular, analysis of intact members showed that whereas eleven families were present in similar copy numbers in B. rapa and B. oleracea, nine families showed copy number variation ranging from 2- to 16-fold. Four of those families (BraSto-3, BraTo-3, 4, 5) were more abundant in B. rapa, and the other five (BraSto-1, BraSto-4, BraTo-1, 7 and BraHAT-1) were more abundant in B. oleracea. Overall, 54% and 51% of the MITEs resided in or within 2 kb of a gene in the B. rapa and B. oleracea genomes, respectively. Notably, 92 MITEs were found within the CDS of annotated genes, suggesting that MITEs might play roles in diversification of genes in the recently triplicated Brassica genome. MITE insertion polymorphism (MIP) analysis of 289 MITE members showed that 52% and 23% were polymorphic at the inter- and intra-species levels, respectively, indicating that there has been recent MITE activity in the Brassica genome. These recently activated MITE families with abundant MIP will provide useful resources for molecular breeding and identification of novel functional genes arising from MITE insertion.

  13. Genome-wide comparative analysis of 20 miniature inverted-repeat transposable element families in Brassica rapa and B. oleracea.

    PubMed

    Sampath, Perumal; Murukarthick, Jayakodi; Izzah, Nur Kholilatul; Lee, Jonghoon; Choi, Hong-Il; Shirasawa, Kenta; Choi, Beom-Soon; Liu, Shengyi; Nou, Ill-Sup; Yang, Tae-Jin

    2014-01-01

    Miniature inverted-repeat transposable elements (MITEs) are ubiquitous, non-autonomous class II transposable elements. Here, we conducted genome-wide comparative analysis of 20 MITE families in B. rapa, B. oleracea, and Arabidopsis thaliana. A total of 5894 and 6026 MITE members belonging to the 20 families were found in the whole genome pseudo-chromosome sequences of B. rapa and B. oleracea, respectively. Meanwhile, only four of the 20 families, comprising 573 members, were identified in the Arabidopsis genome, indicating that most of the families were activated in the Brassica genus after divergence from Arabidopsis. Copy numbers varied from 4 to 1459 for each MITE family, and there was up to 6-fold variation between B. rapa and B. oleracea. In particular, analysis of intact members showed that whereas eleven families were present in similar copy numbers in B. rapa and B. oleracea, nine families showed copy number variation ranging from 2- to 16-fold. Four of those families (BraSto-3, BraTo-3, 4, 5) were more abundant in B. rapa, and the other five (BraSto-1, BraSto-4, BraTo-1, 7 and BraHAT-1) were more abundant in B. oleracea. Overall, 54% and 51% of the MITEs resided in or within 2 kb of a gene in the B. rapa and B. oleracea genomes, respectively. Notably, 92 MITEs were found within the CDS of annotated genes, suggesting that MITEs might play roles in diversification of genes in the recently triplicated Brassica genome. MITE insertion polymorphism (MIP) analysis of 289 MITE members showed that 52% and 23% were polymorphic at the inter- and intra-species levels, respectively, indicating that there has been recent MITE activity in the Brassica genome. These recently activated MITE families with abundant MIP will provide useful resources for molecular breeding and identification of novel functional genes arising from MITE insertion. PMID:24747717

  14. Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes

    PubMed Central

    Klein, Brianna J; Lalonde, Marie-Eve; Côté, Jacques; Yang, Xiang-Jiao; Kutateladze, Tatiana G

    2014-01-01

    The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation. PMID:24169304

  15. Score a Facilities Hat Trick: Strategic Goals for Successful Hiring, Training, and Team Commitment

    ERIC Educational Resources Information Center

    Loy, Darcy

    2012-01-01

    Granted, it might be a bit of a stretch to find comparable attributes between an ice hockey team and facilities management organizations. However, if you are open-minded to the possibility and begin to analyze each of these entities, you will find there are some distinct similarities. Ice hockey is a fast-paced and ever-changing game, much like a…

  16. The Many Hats of an Instructional Designer: The Development of an Instructional Card Game.

    ERIC Educational Resources Information Center

    Sugar, William; Betrus, Anthony

    2002-01-01

    Discusses the difficulties in defining instructional technology, suggests core competencies, proposes five instructional designer archetypes, and describes the development of an instructional card game designed for graduate students in instructional design to expose them to major responsibilities of an instructional designer and give them insight…

  17. Gay Parents Do Exist: Letting the Rabbit out of the Hat

    ERIC Educational Resources Information Center

    Chasnoff, Debra

    2005-01-01

    The truth is that today, millions of children have a parent, uncle, aunt, cousin, sibling or grandparent who is gay. Thousands of dedicated teachers, school administrators and coaches are gays or lesbians. What kind of message is being sent to youth when people say that their loved ones and trusted mentors are not safe for children to meet on TV?…

  18. [Trabecular hyalinizing adenoma of the thyroid (HAT): A report of two cases].

    PubMed

    Román-González, Alejandro; Simón-Duque, Carlos; Camilo-Pérez, Juan; Vélez-Hoyo, Alejandro

    2016-01-01

    The hyalinizing trabecular adenoma is a rare lesion of the thyroid. There is controversy in the literature about the correct name for this disease. Dr. Carney defended the benign nature of this condition and therefore continues calling it adenoma, the World Health Organization calls for the potential of tumor malignancy, and others qualify it as a variant of papillary carcinoma based on the presence of rearranged in transformation/papillary thyroid carcinoma (RET/PTC) rearrangements. In Latin America there are few reported cases. Two cases of hyalinizing trabecular adenoma are reported. The first is a 40-year-old woman with a thyroid nodule of 3x3 cm. The immunohistochemistry was positive for thyroglobulin and calcitonin and negative for cytokeratin 19 and chromogranin. The second case is a 36-year-old patient with a thyroid nodule of 4x4 cm with an immunohistochemical pattern identical to the first case. Trabecular hyalinizing adenoma is a benign disease, easily confused with papillary or medullary thyroid carcinoma. Awareness of this entity will allow a better classification and management of thyroid conditions. PMID:26927651

  19. Assessment of the Damage Tolerance of Postbuckled Hat-Stiffened Panels Using Single-Stringer Specimens

    NASA Technical Reports Server (NTRS)

    Bisagni, Chiara; Vescovini, Riccardo; Davila, Carlos G.

    2010-01-01

    A procedure is proposed for the assessment of the damage tolerance and collapse of stiffened composite panels using a single-stringer compression specimen. The dimensions of the specimen are determined such that the specimen s nonlinear response and collapse are representative of an equivalent multi-stringer panel in compression. Experimental tests are conducted on specimens with and without an embedded delamination. A shell-based finite element model with intralaminar and interlaminar damage capabilities is developed to predict the postbuckling response as well as the damage evolution from initiation to collapse.

  20. "Tied together like a woven hat:" Protective pathways to Alaska native sobriety

    PubMed Central

    Mohatt, Gerald V; Rasmus, S Michelle; Thomas, Lisa; Allen, James; Hazel, Kelly; Hensel, Chase

    2004-01-01

    Background The People Awakening Project (1RO1 AA 11446-03) had two purposes, completed in Phase I and Phase II of the project. The purpose of Phase I was to complete a qualitative study; the research objective was discovery oriented with the specific aim of identification of protective and recovery factors in Alaska Native sobriety. Results were used to develop a heuristic model of protective and recovery factors, and measures based on these factors. The research objective of Phase II was to pilot these measures and provide initial validity data. Methods Phase I utilized a life history methodology. People Awakening interviewed a convenience sample of 101 Alaska Natives who had either recovered from alcoholism (n = 58) or never had a drinking problem (n = 43). This later group included both lifetime abstainers (LAs) and non-problem drinkers (NPs). Life histories were transcribed and analyzed using grounded theory and consensual data analytic procedures within a participatory action research framework. Analyses were utilized to generate heuristic models of protection and recovery from alcohol abuse among Alaska Natives. Results Analyses generated a heuristic model of protective factors from alcohol abuse. The resulting multilevel and multi-factorial model describes interactive and reciprocal influences of (a) individual, family, and community characteristics; (b) trauma and the individual and contextual response to trauma, (c) experimental substance use and the person's social environment; and (d) reflective processes associated with a turning point, or a life decision regarding sobriety. The importance of cultural factors mediating all these protective processes is emphasized. For NPs, the resilience process drew from personal stores of self-confidence, self-efficacy, and self-mastery that derived from ability to successfully maneuver within stressful or potentially traumatizing environments. In contrast, for many LAs, efficacy was instead described in more socially embedded terms better understood as communal mastery. One style of mastery is more associated with individualistic orientations, the other with more collectivistic. Future research is needed regarding the generalizeability of this group difference. Conclusions Results suggest that preventative interventions should focus on intervening simultaneously at the community, family, and individual levels to build resilience and protective factors at each level. Of particular importance is the building of reflexivity along with other cognitive processes that allow the individual to think through problems and to reach a life decision to not abuse alcohol. PMID:15548331

  1. Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS).

    PubMed

    Moayyeri, Alireza; Hart, Deborah J; Snieder, Harold; Hammond, Christopher J; Spector, Timothy D; Steves, Claire J

    2016-02-01

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal clinical data were collected on 3,508 female twins in the TwinsUK registry (complete pairs:740 monozygotic (MZ), 986 dizygotic (DZ), mean age at entry 48.9 ± 10.4, range 18-75 years; mean follow-up 10.2 ± 2.8 years, range 4-17.8 years). Panel data on multiple age-related variables were used to estimate biological ages for each individual at each time point, in linear mixed effects models. A weighted average approach was used to combine variables within predefined body system groups. Aging trajectories for each system in each individual were then constructed using linear modeling. Multivariate structural equation modeling of these aging trajectories showed low genetic effects (heritability), ranging from 2% in metabolic aging to 22% in cardiovascular aging. However, we found a significant effect of shared environmental factors on the variations in aging trajectories in cardiovascular (54%), skeletal (34%), morphometric (53%), and metabolic systems (53%). The remainder was due to environmental factors unique to each individual plus error. Multivariate Cholesky decomposition showed that among aging trajectories for various body systems there were significant and substantial correlations between the unique environmental latent factors as well as shared environmental factors. However, there was no evidence for a single common factor for aging. This study, the first of its kind in aging, suggests that diverse organ systems share non-genetic sources of variance for aging trajectories. Confirmatory studies are needed using population-based twin cohorts and alternative methods of handling missing data.

  2. Wearing More than One Hat: Improving Student-Authored Case Longevity while Encouraging Additional Student Roles

    ERIC Educational Resources Information Center

    Corrigan, Hope; Craciun, Georgiana

    2012-01-01

    The marketing education literature emphasizes and documents the effectiveness of using the student-authored case (SAC) method as a means to develop managerial and critical thinking skills. However, most SACs are short lived, lack suggested case solutions, do not benefit from peer feedback, and present challenges in finding relevant company data.…

  3. "Good Guys Don't Wear Hats": Children's Talk about the Media.

    ERIC Educational Resources Information Center

    Tobin, Joseph

    This book details an ethnographic study focused on how children think and talk about media representations of violence, gender, race, colonialism, and social class. Participating in the study were 162 elementary school students in Hawaii. Groups of 6- to 12-year-olds viewed clips from 2 television commercials and 2 movies and were later…

  4. VizieR Online Data Catalog: HATS-2b griz light curves (Mohler-Fischer+, 2013)

    NASA Astrophysics Data System (ADS)

    Mohler-Fischer, M.; Mancini, L.; Hartman, J. D.; Bakos, G. A.; Penev, K.; Bayliss, D.; Jordan, A.; Csubry, Z.; Zhou, G.; Rabus, M.; Nikolov, N.; Brahm, R.; Espinoza, N.; Buchhave, L. A.; Beky, B.; Suc, V.; Csak, B.; Henning, T.; Wright, D. J.; Tinney, C. G.; Addison, B. C.; Schmidt, B.; Noyes, R. W.; Papp, I.; Lazar, J.; Sari, P.; Conroy, P.

    2013-10-01

    Files contain the data used to plot the lightcurves in Fig. 2, 6 and 7 in the paper. The data were obtained using two different instruments: GROND mounted on the MPG/ESO 2.2 telescope in La Silla Observatory, and the Spectral imaging camera, mounted at 2.0m FTS at Siding Spring Observatory. (9 data files).

  5. Developmental genetics and psychopathology: some new feathers for a fine old hat.

    PubMed

    Johnson, Wendy

    2012-11-01

    Without even knowing of their existence, Mendel discovered how genes operate when they are completely penetrant, although they rarely are, at least with respect to human personality and psychopathology; yet quantitative genetics results have conclusively demonstrated their substantial macrolevel influence. Now we need to understand just how incompletely penetrant genes make their contributions to psychopathology. Exciting new developments in molecular genetics and epigenetics provide new insight into gene action in principle but have been of limited value so far in understanding the emergence of psychopathology. Some of the most helpful postulates might come from evolutionary and developmental biology and agricultural breeding experiments. I describe the all but forgotten evolutionary mechanisms articulated by Schmalhausen, a Russian evolutionary biologist whose work was suppressed by Stalin in the 1940s. I focus on Schmalhausen's law, the observation that organisms living in conditions at the boundary of their tolerance in any one aspect of existence will be vulnerable to expression of genetic liabilities related to all other aspects of existence. I show how Schmalhausen's ideas are relevant to the results of a century-long corn-breeding experiment and the current concepts of facilitated variation and cryptic genetic variation. I then discuss the relevance of all of these to understanding genetic influences on personality and psychopathology.

  6. Adaptation of Foreign Students to the Foreign Culture Learning Environment Using the Six Thinking Hats Method

    ERIC Educational Resources Information Center

    Stanislavovna, Vershinina Tatiana; Leopoldovna, Kocheva Olga

    2015-01-01

    The contemporary life is characterized by various ways and forms of communication, sometimes but not always successful and leading to conflict situations. When a man occurs in the environment, alien to him, he meets misunderstanding and is overwhelmed with incomprehensible emotions as if he were covered with an avalanche. He has to solve problems…

  7. The G-HAT Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies

    NASA Astrophysics Data System (ADS)

    Wright, Jason Thomas; Povich, Matthew; Griffith, Roger; Maldonado, Jessica; Sigurdsson, Steinn; Star Cartier, Kimberly

    2015-08-01

    The WISE and Spitzer large-area surveys of the mid-infrared sky bring a new opportunity to search for evidence of the energy supplies of very large extraterrestrial civilizations. If these energy supplies rival the output of a civilization's parent star (Kardashev Type II), or if a galaxy-spanning supercivilization's use rivals that of the total galactic luminosity (Type III), they would be detectable as anomolously mid-infrared-bright stars and galaxies, respectively. We have already performed the first search for this emission from Type III civilizations using the WISE all-sky survey, and put the first upper limits on them in the local universe, and discuss ways to improve on these limits. We also discuss some detectable forms of and limits on Type II civilizations in the Mliky Way.

  8. "Which Hat Are You Wearing Today?" Ethical Challenges in Dual Employment.

    ERIC Educational Resources Information Center

    Bjorner, Susan N.

    1991-01-01

    Establishes a framework for personal decision making for librarians confronted with conflict of interest situations that arise as a result of working part-time as a freelance information entrepreneur and part-time as a library employee. Codes of ethics of professional organizations are examined, and the organizational environment is considered.…

  9. Histone Acetyl Transferase (HAT) HBO1 and JADE1 in Epithelial Cell Regeneration

    PubMed Central

    Havasi, Andrea; Haegele, Joseph A.; Gall, Jonathan M.; Blackmon, Sherry; Ichimura, Takaharu; Bonegio, Ramon G.; Panchenko, Maria V.

    2014-01-01

    HBO1 acetylates lysine residues of histones and is involved in DNA replication and gene transcription. Two isoforms of JADE1, JADE1S and JADE1L, bind HBO1 and promote acetylation of histones in chromatin context. We characterized the role of JADE1-HBO1 complexes in vitro and in vivo during epithelial cell replication. Down-regulation of JADE1 by siRNA diminished the rate of DNA synthesis in cultured cells, decreased endogenous HBO1 protein expression, and prevented chromatin recruitment of replication factor Mcm7, demonstrating that JADE1 is required for cell proliferation. We used a murine model of acute kidney injury to examine expression of HBO1-JADE1S/L in injured and regenerating epithelial tissue. In control kidneys, JADE1S, JADE1L, and HBO1 were expressed in nuclei of proximal and distal tubular epithelial cells. Ischemia and reperfusion injury resulted in an initial decrease in JADE1S, JADE1L, and HBO1 protein levels, which returned to baseline during renal recovery. HBO1 and JADE1S recovered as cell proliferation reached its maximum, whereas JADE1L recovered after bulk proliferation had ceased. The temporal expression of JADE1S correlated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3 on lysine 14, demonstrating that the JADE1S-HBO1 complex specifically marks H4 during epithelial cell proliferation. These data implicate JADE1-HBO1 complex in acute kidney injury and suggest distinct roles for JADE1 isoforms during epithelial cell recovery. PMID:23159946

  10. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    ERIC Educational Resources Information Center

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  11. Geologic map of the Lassen Peak, Chaos Crags, and Upper Hat Creek area, California

    USGS Publications Warehouse

    Christiansen, Robert L.; Clynne, Michael A.; Muffler, L.J. Patrick

    2002-01-01

    This digital publication contains all the information used to publish U.S. Geological Survey Geologic Investigations Series I-2723 (Christiansen and others, 2002). The map shows the distribution and relationships of volcanic and surficial-sedimentary deposits in an area of Lassen Volcanic National Park and vicinity. Emphasis is on products of the 1914-1917 eruptions of Lassen Peak and the approximately 1000-year-old eruptions of Chaos Crags. ArcInfo grids were prepared from scanned composite images of four U.S. Geological Survey 7.5' topographic quadrangle maps and were georeferenced and reprojected.

  12. QCD radiation in the production of high s-hat final states

    SciTech Connect

    Skands, Peter; Plehn, Tilman; Rainwater, David; /Rochester U.

    2005-11-01

    In the production of very heavy final states--high Mandelstam {cflx s}--extra QCD radiation can play a significant role. By comparing several different parton shower approximations to results obtained with fixed-order perturbation theory, they quantify the degree to which these approaches agree (or disagree), focusing on initial state radiation above p{perpendicular} = 50 GeV, for top pair production at the Tevatron and at the LHC, and for SUSY pair production at the LHC. Special attention is paid to ambiguities associated with the choice of the maximum value of the ordering variable in parton shower models.

  13. Physical fitness of obese school children in Hat Yai, southern Thailand.

    PubMed

    Pongprapai, S; Mo-suwan, L; Leelasamran, W

    1994-06-01

    259 primary school children (average age 9.2 years) were randomly selected from three groups of children whose weights-for-height were 90-110% (normal 111), > 110-120% (over weight 25), and > 120% (obesity 123) of reference values for Bangkok children. They underwent physical fitness tests which included measurement of speed (50 meters run), flexibility (sit-reach), abdominal strength and endurance (30 seconds sit-up), vital capacity (spirometer), and indirect maximum oxygen uptake (VO2 max-submaximal bicycle ergometer). The results showed that all physical fitness tests were statistically significantly different (p < 0.05) between groups, except for flexibility in boys. But for the girls, only 50 meters run, sit-up and VO2 max showed statistically significant differences (p < 0.05). In the comparison of physical fitness tests between sexes, normal weight boys did better than girls (p < 0.05) for all tests except flexibility. There were no statistically significant differences between sexes in overweight and obese children. This study demonstrated that physical fitness of obese children was worse than that of normal children in both sexes, especially as measured by 50 meters run, sit-up and VO2 max tests. Thus, promotion of exercise in obese children should be stimulated to develop better physical fitness and weight reduction. In comparison of physical fitness between the sexes, boys had better physical fitness than girls, significant in the normal weight group only. There is no definite explanation as to why increase in weight results in no difference of physical fitness between sexes. Lifestyle, physical skills, and genetic determinants should be considered for interpretation of physical fitness. PMID:7855656

  14. Reading Is Fun--with a Keyboard, a Hat, and an Alligator.

    ERIC Educational Resources Information Center

    Prinz, Philip M.; Nelson, Keith E.

    1984-01-01

    A program at the Pennsylvania School for the Deaf uses microcomputers to help students initiate communication and play an active role in deciding the topic of communication and the way the lesson proceeds. Preliminary results suggest the program can enhance reading skills as well as broader aspects of language use. (CL)

  15. Commodity Cluster Computing for Remote Sensing Applications using Red Hat LINUX

    NASA Technical Reports Server (NTRS)

    Dorband, John

    2003-01-01

    Since 1994, we have been doing research at Goddard Space Flight Center on implementing a wide variety of applications on commodity based computing clusters. This talk is about these clusters and haw they are used on these applications including ones for remote sensing.

  16. Toward a 21st-Century Understanding of Humans' Relation to Nature: Two Hats?

    ERIC Educational Resources Information Center

    Rennie, Scott

    2008-01-01

    From its inception, environmental education (EE) has shouldered the imposition of impartiality on its methods and practices. Considering the reality of global climate change, the author urges the adoption of the more accurate theory of humans' relation to the natural world. This theory necessitates partiality toward healthy, functioning natural…

  17. Acceptance and mindfulness-based therapy: new wave or old hat?

    PubMed

    Hofmann, Stefan G; Asmundson, Gordon J G

    2008-01-01

    Some contemporary theorists and clinicians champion acceptance and mindfulness-based interventions, such as Acceptance and Commitment Therapy (ACT), over cognitive-behavioral therapy (CBT) for the treatment of emotional disorders. The objective of this article is to juxtapose these two treatment approaches, synthesize, and clarify the differences between them. The two treatment modalities can be placed within a larger context of the emotion regulation literature. Accordingly, emotions can be regulated either by manipulating the evaluation of the external or internal emotion cues (antecedent-focused emotion regulation) or by manipulating the emotional responses (response-focused emotion regulation). CBT and ACT both encourage adaptive emotion regulation strategies but target different stages of the generative emotion process: CBT promotes adaptive antecedent-focused emotion regulation strategies, whereas acceptance strategies of ACT counteract maladaptive response-focused emotion regulation strategies, such as suppression. Although there are fundamental differences in the philosophical foundation, ACT techniques are fully compatible with CBT and may lead to improved interventions for some disorders. Areas of future treatment research are discussed.

  18. Empirical hydrogen-bond potential functions--an old hat reconditioned.

    PubMed

    Korth, Martin

    2011-12-01

    The accurate description of hydrogen-bond interactions is of vital importance for the computational modeling of biological systems. Standard force field (FF) as well as semiempirical quantum mechanical (SQM) methods are now known to have considerable problems with the accurate description of hydrogen bonds. It was found that the performance of SQM methods can be greatly improved with empirical hydrogen-bond correction terms. In the first part of this work we review the improvements developed during the recent revival of dedicated hydrogen-bond terms, also in the light of earlier FF-related work. The second part presents new findings connected to open questions in this field, namely, a study on the importance of angular and torsional information, a scheme how to avoid atom-type-defined target angles and a reduced version of our DH(+) model for the application to force-field methods and physically motivated protein-ligand scoring functions. Our results highlight the importance of using a complete geometric description (including angular and torsional coordinates) for the accurate treatment of hydrogen bonding. The reduced DH(+) model-applied to a modified version of the UFF force field-shows a much improved accuracy for non-covalent interactions also with FF methods, with gains in accuracy by more than one order of magnitude.

  19. Is Field a Hard Hat Area? A Study of Violence in Field Placements.

    ERIC Educational Resources Information Center

    Tully, Carol T.; And Others

    1993-01-01

    A survey of 121 undergraduate and graduate social work students and 96 field instructors found that many students had experienced verbal and physical abuse and that most instructors had experienced verbal abuse and physical violence. Although students received some instruction on safety, practicum agencies often had no safety policies. Curriculum…

  20. Diamonds on the Hat: globular clusters in the Sombrero galaxy (M104)

    NASA Astrophysics Data System (ADS)

    Harris, Wlliam E.; Spitler, Lee R.; Forbes, Duncan A.; Bailin, Jeremy

    2010-01-01

    Images from the Hubble Space Telescope Advanced Camera for surveys are used to carry out a new photometric study of the globular clusters (GCs) in M104, the Sombrero galaxy. The primary focus of our study is the characteristic distribution function of linear sizes [size distribution function (SDF)] of the GCs. We measure the effective radii for 652 clusters with point spread function-convolved King and Wilson dynamical model fits. The SDF is remarkably similar to those measured for other large galaxies of all types, adding strong support to the view that it is a `universal' feature of GC systems. We use the Sombrero and Milky Way data and the formation models of Baumgardt & Kroupa (2007) to develop a more general interpretation of the SDF for GCs. We propose that the shape of the SDF that we see today for GCs is strongly influenced by the early rapid mass loss during their star-forming stage, coupled with stochastic differences from cluster to cluster in the star formation efficiency (SFE) and their initial sizes. We find that the observed SDF shape can be accurately predicted by a simple model in which the protocluster clouds had characteristic sizes of 0.9 +/- 0.1 pc and SFEs of 0.3 +/- 0.07. The colours and luminosities of the M104 clusters show the clearly defined classic bimodal form. The blue sequence exhibits a mass/metallicity relation, following a scaling of heavy-element abundance with luminosity of Z ~ L0.3 very similar to what has been found in most giant elliptical galaxies. A quantitative self-enrichment model provides a good first-order match to the data for the same initial SFE and protocluster size that were required to explain the SDF. We also discuss various forms of the GC Fundamental Plane of structural parameters and show that useful tests of it can be extended to galaxies beyond the Local Group. The M104 clusters strongly resemble those of the Milky Way and other nearby systems in terms of such test quantities as integrated surface density and binding energy. This work was based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. E-mail: harris@physics.mcmaster.ca

  1. Clare Soper's Hat: New Education Fellowship Correspondence between Bloomsbury and New Zealand, 1938-1946

    ERIC Educational Resources Information Center

    Middleton, Sue

    2013-01-01

    Broadening horizons beyond nations, transnational histories trace global flows connecting people and places. Historians have studied the New Education Fellowship (NEF) as a global network. Focused within the nation, research on New Zealand's involvement with NEF has emphasised how its activities before the Second World War impacted on the Labour…

  2. Grey analysis

    SciTech Connect

    Cable, G.D.

    1996-12-01

    Grey logic is not another name for fuzzy logic. Grey logic--also called grey analysis or grey system theory--is a new technology, a group of techniques for system analysis and modeling. Like fuzzy logic, grey logic is useful in situations with incomplete and uncertain information. Grey analysis is particularly applicable in instances with very limited data and in cases with little system knowledge or understanding. In this paper, a summary of the basic concepts of grey analysis is provided, with descriptions of its application to several classes of problems. Calculations methods are provided for grey relation analysis, and for modeling and prediction using grey methods.

  3. Tsetse Fly Control in Kenya's Spatially and Temporally Dynamic Control Reservoirs: A Cost Analysis

    PubMed Central

    McCord, Paul F.; Messina, Joseph P.; Campbell, David J.; Grady, Sue C.

    2011-01-01

    Human African trypanosomiasis (HAT) and animal African trypanosomiasis (AAT) are significant health concerns throughout much of sub-Saharan Africa. Funding for tsetse fly control operations has decreased since the 1970s, which has in turn limited the success of campaigns to control the disease vector. To maximize the effectiveness of the limited financial resources available for tsetse control, this study develops and analyzes spatially and temporally dynamic tsetse distribution maps of Glossina subgenus Morsitans populations in Kenya from January 2002 to December 2010, produced using the Tsetse Ecological Distribution Model. These species distribution maps reveal seasonal variations in fly distributions. Such variations allow for the identification of “control reservoirs” where fly distributions are spatially constrained by fluctuations in suitable habitat and tsetse population characteristics. Following identification of the control reservoirs, a tsetse management operation is simulated in the control reservoirs using capital and labor control inputs from previous studies. Finally, a cost analysis, following specific economic guidelines from existing tsetse control analyses, is conducted to calculate the total cost of a nationwide control campaign of the reservoirs compared to the cost of a nationwide campaign conducted at the maximum spatial extent of the fly distributions from January 2002 to December 2010. The total cost of tsetse management within the reservoirs sums to $14,212,647, while the nationwide campaign at the maximum spatial extent amounts to $33,721,516. This savings of $19,508,869 represents the importance of identifying seasonally dynamic control reservoirs when conducting a tsetse management campaign, and, in the process, offers an economical means of fly control and disease management for future program planning. PMID:22581989

  4. An object-based image analysis of pinyon and juniper woodlands treated to reduce fuels.

    PubMed

    Hulet, April; Roundy, Bruce A; Petersen, Steven L; Jensen, Ryan R; Bunting, Stephen C

    2014-03-01

    Mechanical and prescribed fire treatments are commonly used to reduce fuel loads and maintain or restore sagebrush steppe rangelands across the Great Basin where pinyon (Pinus) and juniper (Juniperus) trees are encroaching and infilling. Geospatial technologies, particularly remote sensing, could potentially be used in these ecosystems to (1) evaluate the longevity of fuel reduction treatments, (2) provide data for planning and designing future fuel-reduction treatments, and (3) assess the spatial distribution of horizontal fuel structure following fuel-reduction treatments. High-spatial resolution color-infrared imagery (0.06-m pixels) was acquired for pinyon and juniper woodland plots where fuels were reduced by either prescribed fire, tree cutting, or mastication at five sites in Oregon, California, Nevada, and Utah. Imagery was taken with a Vexcel UltraCam X digital camera in June 2009. Within each treatment plot, ground cover was measured as part of the Sagebrush Steppe Treatment Evaluation Project. Trimble eCognition Developer was used to classify land cover classes using object-based image analysis (OBIA) techniques. Differences between cover estimates using OBIA and ground-measurements were not consistently higher or lower for any land cover class and when evaluated for individual sites, were within ±5 % of each other. The overall accuracy and the K hat statistic for classified thematic maps for each treatment were: prescribed burn 85 % and 0.81; cut and fell 82 % and 0.77, and mastication 84 % and 0.80. Although cover assessments from OBIA differed somewhat from ground measurements, they are sufficiently accurate to evaluate treatment success and for supporting a broad range of management concerns.

  5. An Object-Based Image Analysis of Pinyon and Juniper Woodlands Treated to Reduce Fuels

    NASA Astrophysics Data System (ADS)

    Hulet, April; Roundy, Bruce A.; Petersen, Steven L.; Jensen, Ryan R.; Bunting, Stephen C.

    2014-03-01

    Mechanical and prescribed fire treatments are commonly used to reduce fuel loads and maintain or restore sagebrush steppe rangelands across the Great Basin where pinyon ( Pinus) and juniper ( Juniperus) trees are encroaching and infilling. Geospatial technologies, particularly remote sensing, could potentially be used in these ecosystems to (1) evaluate the longevity of fuel reduction treatments, (2) provide data for planning and designing future fuel-reduction treatments, and (3) assess the spatial distribution of horizontal fuel structure following fuel-reduction treatments. High-spatial resolution color-infrared imagery (0.06-m pixels) was acquired for pinyon and juniper woodland plots where fuels were reduced by either prescribed fire, tree cutting, or mastication at five sites in Oregon, California, Nevada, and Utah. Imagery was taken with a Vexcel UltraCam X digital camera in June 2009. Within each treatment plot, ground cover was measured as part of the Sagebrush Steppe Treatment Evaluation Project. Trimble eCognition Developer was used to classify land cover classes using object-based image analysis (OBIA) techniques. Differences between cover estimates using OBIA and ground-measurements were not consistently higher or lower for any land cover class and when evaluated for individual sites, were within ±5 % of each other. The overall accuracy and the K hat statistic for classified thematic maps for each treatment were: prescribed burn 85 % and 0.81; cut and fell 82 % and 0.77, and mastication 84 % and 0.80. Although cover assessments from OBIA differed somewhat from ground measurements, they are sufficiently accurate to evaluate treatment success and for supporting a broad range of management concerns.

  6. A comparative analysis of computational approaches and algorithms for protein subcomplex identification.

    PubMed

    Zaki, Nazar; Mora, Antonio

    2014-01-01

    High-throughput AP-MS methods have allowed the identification of many protein complexes. However, most post-processing methods of this type of data have been focused on detection of protein complexes and not its subcomplexes. Here, we review the results of some existing methods that may allow subcomplex detection and propose alternative methods in order to detect subcomplexes from AP-MS data. We assessed and drew comparisons between the use of overlapping clustering methods, methods based in the core-attachment model and our own prediction strategy (TRIBAL). The hypothesis behind TRIBAL is that subcomplex-building information may be concealed in the multiple edges generated by an interaction repeated in different contexts in raw data. The CACHET method offered the best results when the evaluation of the predicted subcomplexes was carried out using both the hypergeometric and geometric scores. TRIBAL offered the best performance when using a strict meet-min score.

  7. A mathematical analysis of the theory of interplanetary scintillation in the weak scattering approximation

    NASA Technical Reports Server (NTRS)

    Mitchell, D. G.; Roelof, E. C.

    1976-01-01

    A simplified analytical technique is presented for modeling the interplanetary scintillation of radio sources of finite angular size with a power-law electron-density-fluctuation power spectrum. The simplification results from the representation of the scintillation spectrum in confluent hypergeometric functions. The approximations presented allow fast numerical evaluation of a spectrum for a weakly scattering but extended medium with less than 10% error over the entire spectrum. Parameters describing anisotropic electron irregularities as well as anisotropic source structure are included, and the dependence of the spectrum normalization on the scales of the medium is derived explicitly. The parametric description of the domains of convergence of the approximate expansions also provides a simple conceptualization of the relative contributions of the scattered radiation along the line of sight to the observed spectrum. This is particularly useful for sources of finite angular size. This technique is applied to previously published observations.

  8. Analysis Software

    NASA Technical Reports Server (NTRS)

    1994-01-01

    General Purpose Boundary Element Solution Technology (GPBEST) software employs the boundary element method of mechanical engineering analysis, as opposed to finite element. It is, according to one of its developers, 10 times faster in data preparation and more accurate than other methods. Its use results in less expensive products because the time between design and manufacturing is shortened. A commercial derivative of a NASA-developed computer code, it is marketed by Best Corporation to solve problems in stress analysis, heat transfer, fluid analysis and yielding and cracking of solids. Other applications include designing tractor and auto parts, household appliances and acoustic analysis.

  9. Development of CAD based on ANN analysis of power spectra for pneumoconiosis in chest radiographs: effect of three new enhancement methods.

    PubMed

    Okumura, Eiichiro; Kawashita, Ikuo; Ishida, Takayuki

    2014-07-01

    We have been developing a computer-aided detection (CAD) scheme for pneumoconiosis based on a rule-based plus artificial neural network (ANN) analysis of power spectra. In this study, we have developed three enhancement methods for the abnormal patterns to reduce false-positive and false-negative values. The image database consisted of 2 normal and 15 abnormal chest radiographs. The International Labour Organization standard chest radiographs with pneumoconiosis were categorized as subcategory, size, and shape of pneumoconiosis. Regions of interest (ROIs) with a matrix size of 32 × 32 were selected from normal and abnormal lungs. Three new enhanced methods were obtained by window function, top-hat transformation, and gray-level co-occurrence matrix analysis. We calculated the power spectrum (PS) of all ROIs by Fourier transform. For the classification between normal and abnormal ROIs, we applied a combined analysis using the ruled-based plus the ANN method. To evaluate the overall performance of this CAD scheme, we employed ROC analysis for distinguishing between normal and abnormal ROIs. On the chest radiographs of the highest categories (severe pneumoconiosis) and the lowest categories (early pneumoconiosis), this CAD scheme achieved area under the curve (AUC) values of 0.93 ± 0.02 and 0.72 ± 0.03. The combined rule-based plus ANN method with the three new enhanced methods obtained the highest classification performance for distinguishing between abnormal and normal ROIs. Our CAD system based on the three new enhanced methods would be useful in assisting radiologists in the classification of pneumoconiosis.

  10. A Relativistic Conical Function and its Whittaker Limits

    NASA Astrophysics Data System (ADS)

    Ruijsenaars, Simon

    2011-11-01

    In previous work we introduced and studied a function R(a_{+},a_{-},c;v,hat{v}) that is a generalization of the hypergeometric function {}_2F_1 and the Askey-Wilson polynomials. When the coupling vector cin{mathbb C}(4) is specialized to (b,0,0,0), bin{mathbb C}, we obtain a function {mathcal R}(a_{+},a_{-},b;v,2hat{v}) that generalizes the conical function specialization of {}_2F_1 and the q-Gegenbauer polynomials. The function {mathcal R} is the joint eigenfunction of four analytic difference operators associated with the relativistic Calogero-Moser system of A_1 type, whereas the function R corresponds to BC_1, and is the joint eigenfunction of four hyperbolic Askey-Wilson type difference operators. We show that the {mathcal R}-function admits five novel integral representations that involve only four hyperbolic gamma functions and plane waves. Taking their nonrelativistic limit, we arrive at four representations of the conical function. We also show that a limit procedure leads to two commuting relativistic Toda Hamiltonians and two commuting dual Toda Hamiltonians, and that a similarity transform of the function {mathcal R} converges to a joint eigenfunction of the latter four difference operators.

  11. Fiber array based hyperspectral Raman imaging for chemical selective analysis of malaria-infected red blood cells.

    PubMed

    Brückner, Michael; Becker, Katja; Popp, Jürgen; Frosch, Torsten

    2015-09-24

    A new setup for Raman spectroscopic wide-field imaging is presented. It combines the advantages of a fiber array based spectral translator with a tailor-made laser illumination system for high-quality Raman chemical imaging of sensitive biological samples. The Gaussian-like intensity distribution of the illuminating laser beam is shaped by a square-core optical multimode fiber to a top-hat profile with very homogeneous intensity distribution to fulfill the conditions of Koehler. The 30 m long optical fiber and an additional vibrator efficiently destroy the polarization and coherence of the illuminating light. This homogeneous, incoherent illumination is an essential prerequisite for stable quantitative imaging of complex biological samples. The fiber array translates the two-dimensional lateral information of the Raman stray light into separated spectral channels with very high contrast. The Raman image can be correlated with a corresponding white light microscopic image of the sample. The new setup enables simultaneous quantification of all Raman spectra across the whole spatial area with very good spectral resolution and thus outperforms other Raman imaging approaches based on scanning and tunable filters. The unique capabilities of the setup for fast, gentle, sensitive, and selective chemical imaging of biological samples were applied for automated hemozoin analysis. A special algorithm was developed to generate Raman images based on the hemozoin distribution in red blood cells without any influence from other Raman scattering. The new imaging setup in combination with the robust algorithm provides a novel, elegant way for chemical selective analysis of the malaria pigment hemozoin in early ring stages of Plasmodium falciparum infected erythrocytes. PMID:26423630

  12. Discovering new methods of data fusion, visualization, and analysis in 3D immersive environments for hyperspectral and laser altimetry data

    NASA Astrophysics Data System (ADS)

    Moore, C. A.; Gertman, V.; Olsoy, P.; Mitchell, J.; Glenn, N. F.; Joshi, A.; Norpchen, D.; Shrestha, R.; Pernice, M.; Spaete, L.; Grover, S.; Whiting, E.; Lee, R.

    2011-12-01

    Immersive virtual reality environments such as the IQ-Station or CAVE° (Cave Automated Virtual Environment) offer new and exciting ways to visualize and explore scientific data and are powerful research and educational tools. Combining remote sensing data from a range of sensor platforms in immersive 3D environments can enhance the spectral, textural, spatial, and temporal attributes of the data, which enables scientists to interact and analyze the data in ways never before possible. Visualization and analysis of large remote sensing datasets in immersive environments requires software customization for integrating LiDAR point cloud data with hyperspectral raster imagery, the generation of quantitative tools for multidimensional analysis, and the development of methods to capture 3D visualizations for stereographic playback. This study uses hyperspectral and LiDAR data acquired over the China Hat geologic study area near Soda Springs, Idaho, USA. The data are fused into a 3D image cube for interactive data exploration and several methods of recording and playback are investigated that include: 1) creating and implementing a Virtual Reality User Interface (VRUI) patch configuration file to enable recording and playback of VRUI interactive sessions within the CAVE and 2) using the LiDAR and hyperspectral remote sensing data and GIS data to create an ArcScene 3D animated flyover, where left- and right-eye visuals are captured from two independent monitors for playback in a stereoscopic player. These visualizations can be used as outreach tools to demonstrate how integrated data and geotechnology techniques can help scientists see, explore, and more adequately comprehend scientific phenomena, both real and abstract.

  13. Jacobian conditioning analysis for model validation.

    PubMed

    Rivals, Isabelle; Personnaz, Léon

    2004-02-01

    Our aim is to stress the importance of Jacobian matrix conditioning for model validation. We also comment on Monari and Dreyfus (2002), where, following Rivals and Personnaz (2000), it is proposed to discard neural candidates that are likely to overfit and/or for which quantities of interest such as confidence intervals cannot be computed accurately. In Rivals and Personnaz (2000), we argued that such models are to be discarded on the basis of the condition number of their Jacobian matrix. But Monari and Dreyfus (2002) suggest making the decision on the basis of the computed values of the leverages, the diagonal elements of the projection matrix on the range of the Jacobian, or "hat" matrix: they propose to discard a model if computed leverages are outside some theoretical bounds, pretending that it is the symptom of the Jacobian rank deficiency. We question this proposition because, theoretically, the hat matrix is defined whatever the rank of the Jacobian and because, in practice, the computed leverages of very ill-conditioned networks may respect their theoretical bounds while confidence intervals cannot be estimated accurately enough, two facts that have escaped Monari and Dreyfus's attention. Wealso recall the most accurate way to estimate the leverages and the properties of these estimations. Finally, we make an additional comment concerning the performance estimation in Monari and Dreyfus (2002). PMID:15006102

  14. Metabolic Analysis

    NASA Astrophysics Data System (ADS)

    Tolstikov, Vladimir V.

    Analysis of the metabolome with coverage of all of the possibly detectable components in the sample, rather than analysis of each individual metabolite at a given time, can be accomplished by metabolic analysis. Targeted and/or nontargeted approaches are applied as needed for particular experiments. Monitoring hundreds or more metabolites at a given time requires high-throughput and high-end techniques that enable screening for relative changes in, rather than absolute concentrations of, compounds within a wide dynamic range. Most of the analytical techniques useful for these purposes use GC or HPLC/UPLC separation modules coupled to a fast and accurate mass spectrometer. GC separations require chemical modification (derivatization) before analysis, and work efficiently for the small molecules. HPLC separations are better suited for the analysis of labile and nonvolatile polar and nonpolar compounds in their native form. Direct infusion and NMR-based techniques are mostly used for fingerprinting and snap phenotyping, where applicable. Discovery and validation of metabolic biomarkers are exciting and promising opportunities offered by metabolic analysis applied to biological and biomedical experiments. We have demonstrated that GC-TOF-MS, HPLC/UPLC-RP-MS and HILIC-LC-MS techniques used for metabolic analysis offer sufficient metabolome mapping providing researchers with confident data for subsequent multivariate analysis and data mining.

  15. Community Analysis.

    ERIC Educational Resources Information Center

    McClarren, Robert R.

    Community analysis has been a prescribed tool of public librarianship for over 25 years. Although its value has been recognized in published public library standards, librarians have rarely used this method of improving library services. Emphasis is placed upon the need for the development of a community analysis methodology for librarians. It is…

  16. Correspondence analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Correspondence analysis is a powerful exploratory multivariate technique for categorical variables with many levels. It is a data analysis tool that characterizes associations between levels of 2 or more categorical variables using graphical representations of the information in a contingency table...

  17. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

    PubMed

    Nagarajan, Prabakaran; Ge, Zhongqi; Sirbu, Bianca; Doughty, Cheryl; Agudelo Garcia, Paula A; Schlederer, Michaela; Annunziato, Anthony T; Cortez, David; Kenner, Lukas; Parthun, Mark R

    2013-06-01

    Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have constructed a conditional mouse knockout model of Hat1. Murine Hat1 is essential for viability, as homozygous deletion of Hat1 results in neonatal lethality. The lungs of embryos and pups genetically deficient in Hat1 were much less mature upon histological evaluation. The neonatal lethality is due to severe defects in lung development that result in less aeration and respiratory distress. Many of the Hat1(-/-) neonates also display significant craniofacial defects with abnormalities in the bones of the skull and jaw. Hat1(-/-) mouse embryonic fibroblasts (MEFs) are defective in cell proliferation and are sensitive to DNA damaging agents. In addition, the Hat1(-/-) MEFs display a marked increase in genome instability. Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly.

  18. Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.

    PubMed

    Duhaime, Michael J; Page, Khaliph O; Varela, Fausto A; Murray, Andrew S; Silverman, Michael E; Zoratti, Gina L; List, Karin

    2016-07-01

    Cancer progression is accompanied by increased levels of extracellular proteases that are capable of remodeling the extracellular matrix, as well as cleaving and activating growth factors and receptors that are involved in pro-cancerous signaling pathways. Several members of the type II transmembrane serine protease (TTSP) family have been shown to play critical roles in cancer progression, however, the expression or function of the TTSP Human Airway Trypsin-like protease (HAT) in carcinogenesis has not been examined. In the present study we aimed to determine the expression of HAT during squamous cell carcinogenesis. HAT transcript is present in several tissues containing stratified squamous epithelium and decreased expression is observed in carcinomas. We determined that HAT protein is consistently expressed on the cell surface in suprabasal/apical layers of squamous cells in healthy cervical and esophageal epithelia. To assess whether HAT protein is differentially expressed in normal tissue versus tissue in different stages of carcinogenesis, we performed a comprehensive immunohistochemical analysis of HAT protein expression levels and localization in arrays of paraffin embedded human cervical and esophageal carcinomas compared to the corresponding normal tissue. We found that HAT protein is expressed in the non-proliferating, differentiated cellular strata and is lost during the dedifferentiation of epithelial cells, a hallmark of squamous cell carcinogenesis. Thus, HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas.

  19. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

    PubMed Central

    2010-01-01

    Background Histone acetyltransferase enzymes (HATs) are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity. Results We isolated the elp3+ gene encoding the histone acetyltransferase subunit of the Elongator complex in fission yeast and characterized the phenotype of an Δelp3 mutant. We examined genetic interactions between Δelp3 and two other HAT mutants, Δmst2 and Δgcn5 and used whole genome microarray analysis to analyze their effects on gene expression. Conclusions Comparison of phenotypes and expression profiles in single, double and triple mutants indicate that these HAT enzymes have overlapping functions. Consistent with this, overlapping specificity in histone H3 acetylation is observed. However, there is no evidence for overlap with another HAT enzyme, encoded by the essential mst1+ gene. PMID:20096118

  20. Subservient analysis.

    PubMed

    Meyer, Luiz

    2003-10-01

    'Ought training analysis to be maintained?' This question, posed by Elias da Rocha Barros, chairing the IJP Congress of Training Analysts in 2001, is used by the author as a starting-point from which to present his ideas on the subject. The paper is divided into three parts. In the first the author presents a survey of the principal criticisms directed at training analysis since 1930. He examines a series of papers that have attracted the attention of those who have studied the subject, with the intention of describing the functional organisation of training analysis and its effects. The second part, based on the criticism presented in the first part, deals with the continuous pressure put on training analysis, in order to maintain its 'didactic' character. This transforms it into an autonomous reality, external to the pair, preceding and steering it. The author describes and discusses this structural aspect of its organisation. In the third part he presents two hypotheses about what factors nourish training analysis in spite of the thoroughness of the criticisms aimed at it. He describes training analysis as a fetish and as an ideological construct. As a fetish it is utilised by analysts to deny the limitations of analysis tout court, and as an ideological construct it is used to conceal its symptomatic character, naturalising it through its prescriptive institutional functioning. The author consequently replies to the initial question in the negative, even suggesting that all analysis discriminated as 'training analysis' ought to be abolished, leaving to the analysands the task of taking care of their analyses. This would be a measure that would also assist in the de-ideologisation of the Institution's mode of operation. The third part also contains a discussion and a criticism of a few suggestions addressed to training analysis in order to modify its functioning and character. PMID:14633428

  1. Factor Analysis via Components Analysis

    ERIC Educational Resources Information Center

    Bentler, Peter M.; de Leeuw, Jan

    2011-01-01

    When the factor analysis model holds, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits us to define new optimization criteria and estimation methods for exploratory factor analysis. Although this article is primarily conceptual in nature, an illustrative example and a small simulation show…

  2. Quantitative analysis

    PubMed Central

    Nevin, John A.

    1984-01-01

    Quantitative analysis permits the isolation of invariant relations in the study of behavior. The parameters of these relations can serve as higher-order dependent variables in more extensive analyses. These points are illustrated by reference to quantitative descriptions of performance maintained by concurrent schedules, multiple schedules, and signal-detection procedures. Such quantitative descriptions of empirical data may be derived from mathematical theories, which in turn can lead to novel empirical analyses so long as their terms refer to behavioral and environmental events. Thus, quantitative analysis is an integral aspect of the experimental analysis of behavior. PMID:16812400

  3. Activation analysis

    SciTech Connect

    Alfassi, Z.B. . Dept. of Nuclear Engineering)

    1990-01-01

    This volume contains 16 chapters on the application of activation analysis in the fields of life sciences, biological materials, coal and its effluents, environmental samples, archaeology, material science, and forensics. Each chapter is processed separately for the data base.

  4. Systems Analysis.

    ERIC Educational Resources Information Center

    Loucks, D. P.; Bell, J. M.

    1978-01-01

    Presents a literature review of the analysis of the administrative systems of various environmental programs related to water quality and pollution policy. A list of 70 references published in 1976 and 1977 is also presented. (HM)

  5. WATER ANALYSIS

    EPA Science Inventory

    This review covers developments in water analysis from November 1996 to the end of October 1998, as found in the Chemical Abstracts Service CA Selects for gas chromatography, mass spectrometry, inorganic analytical chemistry, and pollution monitoring. In addition, because develop...

  6. Conversation Analysis.

    ERIC Educational Resources Information Center

    Schiffrin, Deborah

    1990-01-01

    Summarizes the current state of research in conversation analysis, referring primarily to six different perspectives that have developed from the philosophy, sociology, anthropology, and linguistics disciplines. These include pragmatics; speech act theory; interactional sociolinguistics; ethnomethodology; ethnography of communication; and…

  7. Semen Analysis

    MedlinePlus

    ... Email Other share options Semen analysis is a test on the fluid that is released when a man has an orgasm ©1996 - 2016 SART, Society for Assisted Reproductive Technology . All Rights Reserved. ASRM/SART Nondiscrimination Policy ASRM/ ...

  8. Thermal Analysis

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The University of Georgia used NASTRAN, a COSMIC program that predicts how a design will stand up under stress, to develop a model for monitoring the transient cooling of vegetables. The winter use of passive solar heating for poultry houses is also under investigation by the Agricultural Engineering Dept. Another study involved thermal analysis of black and green nursery containers. The use of NASTRAN has encouraged student appreciation of sophisticated computer analysis.

  9. Gem Analysis

    NASA Technical Reports Server (NTRS)

    1981-01-01

    World Gem Laboratory, Inc.'s cathodoluminoscope is an instrument that magnifies a specimen and produces heat-generated light emissions that bring out features important in gemological analysis. It can indicate whether a stone can be successfully cut, useful in the study of growth and strain patterns in diamonds, detection of dyes in jade, and analysis of the growth and structure of rubies and sapphires. In combination with other tests these analyses can separate synthetic from natural gems.

  10. Structural Analysis

    NASA Technical Reports Server (NTRS)

    1991-01-01

    After an 800-foot-tall offshore oil recovery platform collapsed, the engineers at Engineering Dynamics, Inc., Kenner, LA, needed to learn the cause of the collapse, and analyze the proposed repairs. They used STAGSC-1, a NASA structural analysis program with geometric and nonlinear buckling analysis. The program allowed engineers to determine the deflected and buckling shapes of the structural elements. They could then view the proposed repairs under the pressure that caused the original collapse.

  11. Link Analysis

    NASA Astrophysics Data System (ADS)

    Donoho, Steve

    Link analysis is a collection of techniques that operate on data that can be represented as nodes and links. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.

  12. Cleavage Specificity Analysis of Six Type II Transmembrane Serine Proteases (TTSPs) Using PICS with Proteome-Derived Peptide Libraries

    PubMed Central

    Béliveau, François; Leduc, Richard; Overall, Christopher M.

    2014-01-01

    Background Type II transmembrane serine proteases (TTSPs) are a family of cell membrane tethered serine proteases with unclear roles as their cleavage site specificities and substrate degradomes have not been fully elucidated. Indeed just 52 cleavage sites are annotated in MEROPS, the database of proteases, their substrates and inhibitors. Methodology/Principal Finding To profile the active site specificities of the TTSPs, we applied Proteomic Identification of protease Cleavage Sites (PICS). Human proteome-derived database searchable peptide libraries were assayed with six human TTSPs (matriptase, matriptase-2, matriptase-3, HAT, DESC and hepsin) to simultaneously determine sequence preferences on the N-terminal non-prime (P) and C-terminal prime (P’) sides of the scissile bond. Prime-side cleavage products were isolated following biotinylation and identified by tandem mass spectrometry. The corresponding non-prime side sequences were derived from human proteome databases using bioinformatics. Sequencing of 2,405 individual cleaved peptides allowed for the development of the family consensus protease cleavage site specificity revealing a strong specificity for arginine in the P1 position and surprisingly a lysine in P1′ position. TTSP cleavage between R↓K was confirmed using synthetic peptides. By parsing through known substrates and known structures of TTSP catalytic domains, and by modeling the remainder, structural explanations for this strong specificity were derived. Conclusions Degradomics analysis of 2,405 cleavage sites revealed a similar and characteristic TTSP family specificity at the P1 and P1′ positions for arginine and lysine in unfolded peptides. The prime side is important for cleavage specificity, thus making these proteases unusual within the tryptic-enzyme class that generally has overriding non-prime side specificity. PMID:25211023

  13. Intraoperative hepatic artery blood flow predicts early hepatic artery thrombosis after liver transplantation.

    PubMed

    Marín-Gómez, L M; Bernal-Bellido, C; Alamo-Martínez, J M; Porras-López, F M; Suárez-Artacho, G; Serrano-Diaz-Canedo, J; Padillo-Ruiz, J; Gómez-Bravo, M A

    2012-09-01

    Hepatic artery complications after orthotopic liver transplantation are associated with a high rate of graft loss and mortality (23% to 35%) because they can lead to liver ischemia. The reported incidence of hepatic artery thrombosis (HAT) after adult liver transplantation is 2.5% to 6.8%. Typically, these patients are treated with urgent surgical revascularization or emergent liver retransplantation. Since January 2007, we have recorded the postanastomotic hepatic artery flow after revascularization. The aim of this study was to assess the relationship between hepatic blood flow on revascularization and early HAT. Retrospectively, we reviewed perioperative variables from 110 consecutive liver transplantation performed at the Virgen del Rocío University Hospital (Seville, Spain) between January 2007 and October 2010. We evaluated the following preoperative (donor and recipient) and intraoperative variables: donor and recipient age, cytomegalovirus serology, ABO-compatibility, anatomical variations of the donor hepatic artery, number of arterial anastomoses, portal and hepatic artery flow before closure, cold ischemia time, and blood transfusion. These variables were included in a univariate analysis. Of the 110 patients included in the study, 85 (77.7%) were male. The median age was 52 years. ABO blood groups were identical between donor and recipient in all the patients. The prevalence of early HAT was 6.36% (7 of 110). Crude mortality with/without HAT was 22% versus 2% (P = .001), respectively. Crude graft loss rate with/without HAT was 27% versus 4% (P = .003), respectively. Early HAT was shown to be primarily associated with intraoperative hepatic artery blood flow (93.3 mL/min recipients with HAT versus 187.7 mL/min recipients without HAT, P < .0001). No retransplantation showed early HAT. In our experience, intraoperative hepatic artery blood flow predicts early HAT after liver transplantation.

  14. Reentry analysis

    SciTech Connect

    Biehl, F.A.

    1984-05-01

    This paper presents the criteria, previous nuclear experience in space, analysis techniques, and possible breakup enhancement devices applicable to an acceptable SP-100 reentry from space. Reactor operation in nuclear-safe orbit will minimize the radiological risk; the remaining safeguards criteria need to be defined. A simple analytical point mass reentry technique and a more comprehensive analysis method that considers vehicle dynamics and orbit insertion malfunctions are presented. Vehicle trajectory, attitude, and possible breakup enhancement devices will be integrated in the simulation as required to ensure an adequate representation of the reentry process.

  15. Cycle Analysis

    SciTech Connect

    Wright, Steven A.

    2012-03-20

    1. The Cycle Analysis code is an Microsoft Excel code that performs many different types of thermodynamic cycle analysis for power producing systems. The code will calculate the temperature and pressure and all other thermodynamic properties at the inlet and outlet of each component. The code also calculates the power that is produced, the efficiency, and the heat transported in the heater, gas chiller and recuperators. The code provides a schematic of the loop and provides the temperature and pressure at each location in the loop. The code also provides a T-S (temperature-entropy) diagram of the loop and often it provides an pressure enthalpy plot as well. 2. This version of the code concentrates on supercritical CO2 power cycles, but by simply changing the name of the working fluid many other types of fluids can be analyzed. The Cycle Analysis code provided here contains 18 different types of power cycles. Each cycle is contained in one worksheet or tab that the user can select. The user can change the yellow highlighted regions to perform different thermodynamic cycle analysis.

  16. Cycle Analysis

    2012-03-20

    1. The Cycle Analysis code is an Microsoft Excel code that performs many different types of thermodynamic cycle analysis for power producing systems. The code will calculate the temperature and pressure and all other thermodynamic properties at the inlet and outlet of each component. The code also calculates the power that is produced, the efficiency, and the heat transported in the heater, gas chiller and recuperators. The code provides a schematic of the loop andmore » provides the temperature and pressure at each location in the loop. The code also provides a T-S (temperature-entropy) diagram of the loop and often it provides an pressure enthalpy plot as well. 2. This version of the code concentrates on supercritical CO2 power cycles, but by simply changing the name of the working fluid many other types of fluids can be analyzed. The Cycle Analysis code provided here contains 18 different types of power cycles. Each cycle is contained in one worksheet or tab that the user can select. The user can change the yellow highlighted regions to perform different thermodynamic cycle analysis.« less

  17. Analysis Repository

    SciTech Connect

    DOE

    2012-03-16

    The Analysis Repository is a compilation of analyses and analytical models relevant to assessing hydrogen fuel and fuel cell issues. Projects in the repository relate to: hydrogen production, delivery, storage, fuel cells, and hydrogen vehicle technology; hydrogen production feedstock cost and availability; electricity production, central and distributed; energy resource estimation and forecasting.

  18. Genome-wide identification of sweet orange (Citrus sinensis) histone modification gene families and their expression analysis during the fruit development and fruit-blue mold infection process.

    PubMed

    Xu, Jidi; Xu, Haidan; Liu, Yuanlong; Wang, Xia; Xu, Qiang; Deng, Xiuxin

    2015-01-01

    In eukaryotes, histone acetylation and methylation have been known to be involved in regulating diverse developmental processes and plant defense. These histone modification events are controlled by a series of histone modification gene families. To date, there is no study regarding genome-wide characterization of histone modification related genes in citrus species. Based on the two recent sequenced sweet orange genome databases, a total of 136 CsHMs (Citrus sinensis histone modification genes), including 47 CsHMTs (histone methyltransferase genes), 23 CsHDMs (histone demethylase genes), 50 CsHATs (histone acetyltransferase genes), and 16 CsHDACs (histone deacetylase genes) were identified. These genes were categorized to 11 gene families. A comprehensive analysis of these 11 gene families was performed with chromosome locations, phylogenetic comparison, gene structures, and conserved domain compositions of proteins. In order to gain an insight into the potential roles of these genes in citrus fruit development, 42 CsHMs with high mRNA abundance in fruit tissues were selected to further analyze their expression profiles at six stages of fruit development. Interestingly, a numbers of genes were expressed highly in flesh of ripening fruit and some of them showed the increasing expression levels along with the fruit development. Furthermore, we analyzed the expression patterns of all 136 CsHMs response to the infection of blue mold (Penicillium digitatum), which is the most devastating pathogen in citrus post-harvest process. The results indicated that 20 of them showed the strong alterations of their expression levels during the fruit-pathogen infection. In conclusion, this study presents a comprehensive analysis of the histone modification gene families in sweet orange and further elucidates their behaviors during the fruit development and the blue mold infection responses.

  19. Co-expressed differentially expressed genes and long non-coding RNAs involved in the celecoxib treatment of gastric cancer: An RNA sequencing analysis

    PubMed Central

    Song, Bin; Du, Juan; Feng, Ye; Gao, Yong-Jian; Zhao, Ji-Sheng

    2016-01-01

    The aim of the present study was to investigate the mechanisms of long non-coding RNAs (lncRNAs) in a gastric cancer cell line treated with celecoxib. The human gastric carcinoma cell line NCI-N87 was treated with 15 µM celecoxib for 72 h (celecoxib group) and an equal volume of dimethylsulfoxide (control group), respectively. Libraries were constructed by NEBNext Ultra RNA Library Prep kit for Illumina. Paired-end RNA sequencing reads were aligned to a human hg19 reference genome using TopHat2. Differentially expressed genes (DEGs) and lncRNAs were identified using Cuffdiff. Enrichment analysis was performed using GO-function package and KEGG profile in Bioconductor. A protein-protein interaction network was constructed using STRING database and module analysis was performed using ClusterONE plugin of Cytoscape. ATP5G1, ATP5G3, COX8A, CYC1, NDUFS3, UQCRC1, UQCRC2 and UQCRFS1 were enriched in the oxidative phosphorylation pathway. CXCL1, CXCL3, CXCL5 and CXCL8 were enriched in the chemokine signaling and cytokine-cytokine receptor interaction pathways. ITGA3, ITGA6, ITGB4, ITGB5, ITGB6 and ITGB8 were enriched in the integrin-mediated signaling pathway. DEGs co-expressed with lnc-SCD-1:13, lnc-LRR1-1:2, lnc-PTMS-1:3, lnc-S100P-3:1, lnc-AP000974.1-1:1 and lnc-RAB3IL1-2:1 were enriched in the pathways associated with cancer, such as the basal cell carcinoma pathway in cancer. In conclusion, these DEGs and differentially expressed lncRNAs may be important in the celecoxib treatment of gastric cancer.

  20. Fully Automatic Determination of Soil Bacterium Numbers, Cell Volumes, and Frequencies of Dividing Cells by Confocal Laser Scanning Microscopy and Image Analysis

    PubMed Central

    Bloem, J.; Veninga, M.; Shepherd, J.

    1995-01-01

    We describe a fully automatic image analysis system capable of measuring cell numbers, volumes, lengths, and widths of bacteria in soil smears. The system also determines the number of cells in agglomerates and thus provides the frequency of dividing cells (FDC). Images are acquired from a confocal laser scanning microscope. The grey images are smoothed by convolution and by morphological erosion and dilation to remove noise. The background is equalized by flooding holes in the image and is then subtracted by two top hat transforms. Finally, the grey image is sharpened by delineation, and all particles above a fixed threshold are detected. The number of cells in each detected particle is determined by counting the number of local grey-level maxima in the particle. Thus, up to 1,500 cells in 10 fields of view in a soil smear are analyzed in 30 min without human intervention. Automatic counts of cell numbers and FDC were similar to visual counts in field samples. In microcosms, automatic measurements showed significant increases in cell numbers, FDC, mean cell volume, and length-to-width ratio after amendment of the soil. Volumes of fluorescent microspheres were measured with good approximation, but the absolute values obtained were strongly affected by the settings of the detector sensitivity. Independent measurements of bacterial cell numbers and volumes by image analysis and of cell carbon by a total organic carbon analyzer yielded an average specific carbon content of 200 fg of C (mu)m(sup-3), which indicates that our volume estimates are reasonable. PMID:16534976