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Sample records for heart-lung machine

  1. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  2. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  3. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  4. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  5. 21 CFR 870.4220 - Cardiopulmonary bypass heart-lung machine console.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass heart-lung machine console... Cardiopulmonary bypass heart-lung machine console. (a) Identification. A cardiopulmonary bypass heart-lung machine... heart-lung machine. The console is designed to interface with the basic units used in a gas...

  6. Importance of practical simulation training for troubleshooting the heart-lung machine.

    PubMed

    Kenmoku, Kyoichi

    2009-01-01

    The artificial heart-lung system is a device that replaces the patient's respiratory and circulatory function during surgery on the heart and great vessels. Users must operate the system by properly recognizing and appropriately evaluating various types of information and by providing feedback to the machine; inappropriate interaction between humans and the machine can cause failures. A questionnaire survey showed that the incidence of problem events during the operation of heart-lung machines was 1/300 to 1/100, both within and outside Japan, and that severe events such as permanent disability or death occurred at an incidence of 1/1000 to 1/500. It has been generally reported that the following measures are effective ways of reducing errors: (1) reducing the number of high-risk operations (risk minimization), (2) reducing the probability of occurrence of errors during each operation (probability minimization), (3) implementing multiple error-detecting measures (multiple detection of errors), and (4) having the capacity to minimizing damage (damage limitation). This article discusses effective countermeasures as a result of a questionnaire answered in Japan. The first measure to be taken is to provide both software (i.e., manuals that describe safety measures, checklists, and troubleshooting approaches that are not otherwise readily available) and hardware (i.e., necessary monitoring devices that enhance safety). Second, a standard heart-lung circuit needs to be designed. Third, safety management of medical engineering equipment for cardiac surgery must be strictly performed. Fourth, simulations of practical problems are necessary. People make mistakes, machines can fail, the electricity supply can be cut, consumables may be defective, or consumables may break. The higher the number of people involved, the more easily problems can occur due to the complexity of the system. Failures inevitably occur at a certain frequency. In other words, efforts can reduce the

  7. The Aachen miniaturized heart-lung machine--first results in a small animal model.

    PubMed

    Schnoering, Heike; Arens, Jutta; Sachweh, Joerg S; Veerman, Melanie; Tolba, Rene; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Vazquez-Jimenez, Jaime F

    2009-11-01

    Congenital heart surgery most often incorporates extracorporeal circulation. Due to foreign surface contact and the administration of foreign blood in many children, inflammatory response and hemolysis are important matters of debate. This is particularly an issue in premature and low birth-weight newborns. Taking these considerations into account, the Aachen miniaturized heart-lung machine (MiniHLM) with a total static priming volume of 102 mL (including tubing) was developed and tested in a small animal model. Fourteen female Chinchilla Bastard rabbits were operated on using two different kinds of circuits. In eight animals, a conventional HLM with Dideco Kids oxygenator and Stöckert roller pump (Sorin group, Milan, Italy) was used, and the Aachen MiniHLM was employed in six animals. Outcome parameters were hemolysis and blood gas analysis including lactate. The rabbits were anesthetized, and a standard median sternotomy was performed. The ascending aorta and the right atrium were cannulated. After initiating cardiopulmonary bypass, the aorta was cross-clamped, and cardiac arrest was induced by blood cardioplegia. Blood samples for hemolysis and blood gas analysis were drawn before, during, and after cardiopulmonary bypass. After 1 h aortic clamp time, all animals were weaned from cardiopulmonary bypass. Blood gas analysis revealed adequate oxygenation and perfusion during cardiopulmonary bypass, irrespective of the employed perfusion system. The use of the Aachen MiniHLM resulted in a statistically significant reduced decrease in fibrinogen during cardiopulmonary bypass. A trend revealing a reduced increase in free hemoglobin during bypass in the MiniHLM group could also be observed. This newly developed Aachen MiniHLM with low priming volume, reduced hemolysis, and excellent gas transfer (O(2) and CO(2)) may reduce circuit-induced complications during heart surgery in neonates.

  8. The Aachen MiniHLM--a miniaturized heart-lung machine for neonates with an integrated rotary blood pump.

    PubMed

    Arens, Jutta; Schnoering, Heike; Pfennig, Michael; Mager, Ilona; Vázquez-Jiménez, Jaime F; Schmitz-Rode, Thomas; Steinseifer, Ulrich

    2010-09-01

    The operation of congenital heart defects in neonates often requires the use of heart-lung machines (HLMs) to provide perfusion and oxygenation. This is prevalently followed by serious complications inter alia caused by hemodilution and extrinsic blood contact surfaces. Thus, one goal of developing a HLM for neonates is the reduction of priming volume and contact surface. The currently available systems offer reasonable priming volumes for oxygenators, reservoirs, etc. However, the necessary tubing system contains the highest volumes within the whole system. This is due to the use of roller pumps; hence, the resulting placement of the complete HLM is between 1 and 2 m away from the operating table due to connective tubing between the components. Therefore, we pursued a novel approach for a miniaturized HLM (MiniHLM) by integrating all major system components in one single device. In particular, the MiniHLM is a HLM with the rotary blood pump centrically integrated into the oxygenator and a heat exchanger integrated into the cardiotomy reservoir which is directly connected to the pump inlet. Thus, tubing is only necessary between the patient and MiniHLM. A total priming volume of 102 mL (including arterial filter and a/v line) could be achieved. To validate the overall concept and the specific design we conducted several in vitro and in vivo test series. All tests confirm the novel concept of the MiniHLM. Its low priming volume and blood contact surface may significantly reduce known complications related to cardiopulmonary bypass in neonates (e.g., inflammatory reaction and capillary leak syndrome).

  9. Variations in battery life of a heart-lung machine using different pump speeds, pressure loads, boot material, centrifugal pump head, multiple pump usage, and battery age.

    PubMed

    Marshall, Cornelius; Hargrove, Martin; O'Donnell, Aonghus; Aherne, Thomas

    2005-09-01

    Electrical failure during cardiopulmonary bypass (CPB) has previously been reported to occur in 1 of every 1500 cases. Most heart-lung machine pump consoles are equipped with built-in battery back-up units. Battery run times of these devices are variable and have not been reported. Different conditions of use can extend battery life in the event of electrical failure. This study was designed to examine the run time of a fully charged battery under various conditions of pump speed, pressure loads, pump boot material, multiple pump usage, and battery life. Battery life using a centrifugal pump also was examined. The results of this study show that battery life is affected by pump speed, circuit pressure, boot stiffness, and the number of pumps in service. Centrifugal pumps also show a reduced drain on battery when compared with roller pumps. These elements affect the longevity and performance of the battery. This information could be of value to the individual during power failure as these are variables that can affect the battery life during such a challenging scenario.

  10. Precise quantification of pulsatility is a necessity for direct comparisons of six different pediatric heart-lung machines in a neonatal CPB model.

    PubMed

    Undar, Akif; Eichstaedt, Harald C; Masai, Takafumi; Bigley, Joyce E; Kunselman, Allen R

    2005-01-01

    Generation of pulsatile flow depends on an energy gradient. Surplus hemodynamic energy (SHE) is the extra hemodynamic energy generated by a pulsatile device when the adequate pulsatility is achieved. The objective of this study was to precisely quantify and compare pressure-flow waveforms in terms of surplus hemodynamic energy levels of six different pediatric heart-lung machines in a neonatal piglet model during cardiopulmonary bypass (CPB) procedures with deep hypothermic circulatory arrest (DHCA). Thirty-nine piglets (average weight, 3 kg) were subjected to CPB with a hydraulically driven physiologic pulsatile pump (PPP; n=7), Jostra-HL 20 pulsatile roller pump (Jostra-PR; n=6), Stockert Sill pulsatile roller pump (SIII-PR; n=6), Stockert Sill mast-mounted pulsatile roller pump with a miniature roller head (Mast-PR; n=7), Stockert Sill mast-mounted nonpulsatile roller pump (Mast-NP; n=7), or Stockert CAPS nonpulsatile roller pump (CAPS-NP, n=7). Once CPB was begun, each animal underwent 20 minutes of hypothermia, 60 minutes of DHCA, 10 minutes of cold reperfusion, and 40 minutes of rewarming. The pump flow rate was maintained at 150 ml x kg(-1) x min(-1) and the mean arterial pressure (MAP) at 45 mm Hg. In the pulsatile experiments, the pump rate was kept at 150 bpm and the stroke volume at 1 ml/kg. The SHE (ergs/cm3) = 1,332 ([(integral fpdt) / (integral fdt)] - MAP) was calculated at each experimental stage. During normothermic CPB (15 minutes on pump), the physiologic pulsatile pump generated the highest surplus hemodynamic energy (8563 +/- 1918 ergs/cm3, p < 0.001) compared with all other pumps. The Jostra HL-20 and Stockert Sill pulsatile roller pumps also produced adequate surplus hemodynamic energy. Nonpulsatile roller pumps and the Stockert Sill mast-mounted pulsatile roller pump did not generate any extra hemodynamic energy. During hypothermic CPB and after DHCA and rewarming, the results were extremely similar to those seen during normothermic CPB. The

  11. Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine.

    PubMed

    Eckert, Elisabeth; Münch, Frank; Göen, Thomas; Purbojo, Ariawan; Müller, Johannes; Cesnjevar, Robert

    2016-02-01

    Medical devices like blood tubing often consist of PVC material that requires the addition of plasticizers. These plasticizers may migrate into the blood leading to an exposure of the patients. In this study the migration behavior of three different blood tubing sets (PVC material with two different plasticizers and silicone as control material) applied on a heart-lung machine standardly used for cardiopulmonary bypass (CPB) in children was studied. We analyzed the total plasticizer migration by analysis of both, the parent compounds as well as their primary degradation products in blood. Additionally, the total mass loss of the tubing over perfusion time was examined. The PVC tubing plasticized with DEHP (di-2-ethylhexyl phthalate) was found to have the highest mass loss over time and showed a high plasticizer migration rate. In comparison, the migration of TOTM (tri-2-ethylhexyl trimellitate) and its primary degradation products was found to be distinctly lower (by a factor of approx. 350). Moreover, it was observed that the storage time of the tubing affects the plasticizer migration rates. In conclusion, the DEHP substitute TOTM promises to be an effective alternative plasticizer for PVC medical devices particularly regarding the decreased migration rate during medical procedures.

  12. Beginnings of open-heart surgery in Gdansk – double role of the Pemco heart-lung machine and new facts about Dutch-Polish cooperation

    PubMed Central

    2016-01-01

    The first open-heart surgery in Gdansk took place in 1975. It was possible thanks to the gift of a Pemco extracorporeal circulation machine from the Netherlands to the Surgery Institute of the Medical Academy of Gdansk. The article presents additional, unpublished informations which enable a new interpretation of the previously known facts. PMID:27516801

  13. National Heart, Lung, and Blood Institute

    MedlinePlus

    ... how our TOPMed program is designed to enable precision medicine for heart, lung, blood and sleep disorders? ... programs, initiatives and research resources . Featured programs: NHLBI Precision Medicine Activities NHLBI AIDS Program Funding Opportunities NOT- ...

  14. 76 FR 30371 - National Heart, Lung, and Blood Institute; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Heart, Lung, and Blood Institute; Meetings Notice of Closed Meetings Pursuant to section 10(d) of the... constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206, Bethesda, MD 20892-7924,...

  15. 76 FR 21387 - National Heart, Lung, and Blood Institute;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; BABYHUG Data.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182, Bethesda, MD...

  16. Heart-Lung Interactions in Aerospace Medicine

    NASA Technical Reports Server (NTRS)

    Guy, Harold J. B.; Prisk, Gordon Kim

    1991-01-01

    Few of the heart-lung interactions that are discussed have been studied in any detail in the aerospace environment, but is seems that many such interactions must occur in the setting of altered accelerative loadings and pressure breathing. That few investigations are in progress suggests that clinical and academic laboratory investigators and aerospace organizations are further apart than during the pioneering work on pressure breathing and acceleration tolerance in the 1940s. The purpose is to reintroduce some of the perennial problems of aviation physiology as well as some newer aerospace concerns that may be of interest. Many possible heart-lung interactions are pondered, by necessity often drawing on data from within the aviation field, collected before the modern understanding of these interactions developed, or on recent laboratory data that may not be strictly applicable. In the field of zero-gravity effects, speculation inevitably outruns the sparse available data.

  17. 76 FR 30372 - National Heart, Lung, and Blood Institute; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... No: 2011-12946] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart... clearly unwarranted invasion of personal privacy. Name of Committee: Heart, Lung, and Blood Initial Review... Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda,...

  18. 77 FR 30541 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD...

  19. 76 FR 10912 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Room...

  20. 77 FR 12599 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD...

  1. 78 FR 13880 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... Review/DERA, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701...

  2. 77 FR 66854 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... Scientific Review/DERA, National Heart, Lung, and Blood Institute, National Institutes of Health,...

  3. 76 FR 28996 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  4. 75 FR 68368 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Heart, Lung, and Blood Program Project... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  5. 78 FR 67370 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... Review/DERA National Heart, Lung, and Blood Institute, National Institutes of Health, 6701...

  6. 75 FR 29356 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7208, Bethesda, MD 20892-7924,...

  7. Heart, Lung Problems May Not Always Need ICU Care

    MedlinePlus

    ... Heart, Lung Problems May Not Always Need ICU Care Study finds no difference in death rates, but higher ... for COPD patients in the ICU or regular care, the study found. The researchers also found that ICU patients ...

  8. 78 FR 45933 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Cardiovascular... (Telephone Conference Call). Contact Person: Susan Wohler Sunnarborg, Ph.D., Scientific Review...

  9. Cardiopulmonary bypass: development of John Gibbon's heart-lung machine

    PubMed Central

    Passaroni, Andréia Cristina; Silva, Marcos Augusto de Moraes; Yoshida, Winston Bonetti

    2015-01-01

    Objective To provide a brief review of the development of cardiopulmonary bypass. Methods A review of the literature on the development of extracorporeal circulation techniques, their essential role in cardiovascular surgery, and the complications associated with their use, including hemolysis and inflammation. Results The advancement of extracorporeal circulation techniques has played an essential role in minimizing the complications of cardiopulmonary bypass, which can range from various degrees of tissue injury to multiple organ dysfunction syndrome. Investigators have long researched the ways in which cardiopulmonary bypass may insult the human body. Potential solutions arose and laid the groundwork for development of safer postoperative care strategies. Conclusion Steady progress has been made in cardiopulmonary bypass in the decades since it was first conceived of by Gibbon. Despite the constant evolution of cardiopulmonary bypass techniques and attempts to minimize their complications, it is still essential that clinicians respect the particularities of each patient's physiological function. PMID:26107456

  10. 77 FR 33473 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel HIV Lung Disease and... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  11. 77 FR 43343 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Jackson Heart Study RFA Review..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924,...

  12. 77 FR 1702 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  13. 78 FR 2680 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; K23, K24, K25 Research Career.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD...

  14. 77 FR 75180 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  15. 78 FR 32408 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group NHLBI Institutional Training Mechanism... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  16. 78 FR 66025 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7185, Bethesda,...

  17. 77 FR 18252 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  18. 75 FR 66771 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... ] Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Centers for..., Scientific Review Officer, Office of Scientific Review, National Heart, Lung, and Blood Institute,...

  19. 77 FR 71428 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI T32 Training..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7189, Bethesda, MD 20892,...

  20. 77 FR 71429 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Jackson Heart Study..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924,...

  1. 78 FR 31952 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  2. 75 FR 71450 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Institutional National.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7176, Bethesda, MD...

  3. 77 FR 12602 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Creazzo, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  4. 78 FR 7795 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Review of a resource....D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and...

  5. 78 FR 42967 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Pediatric Pulmonary... Sunnarborg, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  6. 75 FR 66772 - National Heart, Lung, and Blood Institute; Notice of Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute... Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes...

  7. 78 FR 12767 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational... Scientific Review/DERA, National, Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7182,...

  8. 78 FR 37233 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mechanisms of HIV..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  9. 76 FR 57062 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Translational... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  10. 77 FR 59935 - National Heart, Lung, And Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, And Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Engine for Fast... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180,...

  11. 78 FR 57866 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sample Biorepository and... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  12. 78 FR 42970 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Short-term Training... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  13. 76 FR 78285 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel,SBIR Topic 56 Blood..., DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7198, Bethesda, MD...

  14. 78 FR 12073 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Clinical Trials SEP... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7188, Bethesda,...

  15. 78 FR 66031 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Novel Tools...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  16. 75 FR 65498 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Career Enhancement... Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  17. 77 FR 13134 - National Heart, Lung, and Blood Institute: Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute: Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sickle Cell Disease... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7198,...

  18. 76 FR 2128 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Loan Repayment... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924....

  19. 77 FR 1703 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Program Project Grant... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206,...

  20. 78 FR 29375 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  1. 75 FR 42100 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy: Name of Committee: National Heart, Lung, and...

  2. 75 FR 4829 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date...: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  3. 77 FR 59939 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Phase... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda,...

  4. 78 FR 12766 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Topic 80... Sunnarborg, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National, Heart, Lung,...

  5. 77 FR 2738 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Wireless Physiologic... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7204,...

  6. 76 FR 58523 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... of Committee: National Heart, Lung, and Blood Advisory Council. ] Date: October 18, 2011. Open: 8...

  7. 77 FR 10538 - National Heart, Lung, and Blood Institute Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Cardiothoracic... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  8. 77 FR 31863 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  9. 78 FR 63994 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Genetic Basis of... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  10. 78 FR 33428 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  11. 76 FR 12362 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  12. 77 FR 30542 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Career... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm. 7202,...

  13. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mentored Career... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186, Bethesda, MD 20892-7924,...

  14. 77 FR 32651 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee... Person: Keary A Cope, Ph.D., Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  15. 77 FR 36565 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7200, Bethesda, MD 20892,...

  16. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Program Project... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  17. 78 FR 7792 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Contract... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  18. 77 FR 69639 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; PETAL... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  19. 77 FR 60705 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Minority... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda,...

  20. 77 FR 9670 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Novel Technologies..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892, 301-...

  1. 77 FR 61421 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Webb, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  2. 75 FR 48979 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ischemia Trials. Date...). Contact Person: Youngsuk Oh, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  3. 77 FR 59939 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date...., Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701...

  4. 77 FR 31863 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Understanding..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  5. 76 FR 11253 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; MAPGen and MAPGenKB..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  6. 78 FR 27411 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Program Project... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  7. 78 FR 7791 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Resource related..., Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and...

  8. 77 FR 2739 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Genetics of Heart... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7200,...

  9. 75 FR 80831 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel... Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  10. 78 FR 58321 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  11. 78 FR 42529 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Resource related... Review Officer, Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute,...

  12. 77 FR 38849 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Long Term..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  13. 78 FR 22272 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Loan... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192,...

  14. 76 FR 1186 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Multiplexed Assay... Review Officer. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis...

  15. 77 FR 6809 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Technologies... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  16. 77 FR 24728 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Sudden..., Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  17. 76 FR 42718 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Consortium of Lung... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924,...

  18. 77 FR 69869 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... ] Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Sleep Research..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  19. 77 FR 22580 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  20. 78 FR 52937 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Wireless... Review Officer, Office of Scientific Review/DERA, National, Heart, Lung, and Blood Institute,...

  1. 76 FR 25701 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Heart Pumps... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179,...

  2. 78 FR 37836 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Conference... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7185, Bethesda,...

  3. 76 FR 1441 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  4. 78 FR 11657 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Allogeneic Transplant... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  5. 77 FR 45644 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of... the National Heart, Lung, and Blood Advisory Council. The meeting will be closed to the public in... privacy. Name of Committee: National Heart, Lung, and Blood Advisory Council Date: September 11,...

  6. 75 FR 42756 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ...: Robert T. Su, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood...: Robert Blaine Moore, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of...

  7. 75 FR 21644 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    .... Creazzo, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Lung Tissue...

  8. 76 FR 5596 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ...: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee....

  9. 76 FR 70462 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program Project...: Jeffrey H. Hurst, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart,...

  10. 77 FR 47858 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ancillary Studies in Clinical.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7179, Bethesda, MD...

  11. 76 FR 71580 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, NHLBI Institutional Training Mechanism... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda,...

  12. 78 FR 6127 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Mentored Career..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192, Bethesda, MD 20892,...

  13. 78 FR 16859 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Resource-related..., Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186,...

  14. 78 FR 17937 - National Heart, Lung, and Blood Institute; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Closed Meeting... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NIH Centers for Accelerated... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7198, Bethesda,...

  15. 78 FR 17419 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  16. 78 FR 39300 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ...: 2013-15570] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda,...

  17. 77 FR 8271 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Planning Studies for... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7200, Bethesda,...

  18. 78 FR 6122 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Biological.... Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  19. 78 FR 55268 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mentored Transition... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192, Bethesda,...

  20. 78 FR 48880 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Randomized Trial on...., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  1. 78 FR 35637 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Functional Assays to... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge ] Drive, Room...

  2. 76 FR 71986 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Ancillary Studies.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD...

  3. 76 FR 61720 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Cardiovascular... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196,...

  4. 77 FR 73037 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Short-term Heart, Lung and Blood Training. Date: January 8, 2013. Time: 1:00 p.m. to 2:30 p.m. Agenda: To...

  5. 76 FR 12123 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Blood & Marrow..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186, Bethesda, MD 20892-7924,...

  6. 77 FR 16843 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Novel Clinical Trial..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7180, Bethesda, MD 20892-7924,...

  7. 76 FR 61722 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Data Coordinating... Review Officer, Review Branch, DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  8. 75 FR 9912 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance... of Committee: Heart, Lung, and Blood Initial Review Group; Heart, Lung, and Blood Program...

  9. 76 FR 63625 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive... Heart, Lung, and Blood Institute Special Emphasis Panel, Blood Pressure Regulations PPG. Date:...

  10. 78 FR 50427 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  11. 78 FR 69431 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research Career... Officer, Office of Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  12. 78 FR 69432 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Clinical Trials... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7188,...

  13. 77 FR 67827 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Ancillary Studies..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda, MD 20892-7924,...

  14. 78 FR 69431 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; PETAL Clinical... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178,...

  15. 78 FR 54259 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; K23, K24, K25..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892,...

  16. 77 FR 59200 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Mentored Career..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192, Bethesda, MD 20892,...

  17. 76 FR 12744 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Inflammation and... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7192, Bethesda, MD 20892, 301-...

  18. 75 FR 54642 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Maintenance... Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  19. 77 FR 43098 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Asthma in Older.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD...

  20. 77 FR 6571 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee Date... Person: Keary A Cope, Ph.D., Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  1. 75 FR 61507 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Research... Branch, DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda,...

  2. 76 FR 16631 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed...@nhlbi.nih.gov . Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD...

  3. 77 FR 6571 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Minority.../DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD...

  4. 76 FR 47218 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Training Grant Review... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7176, Bethesda, MD 20892-7924,...

  5. 77 FR 14533 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Basic Research in..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7204, Bethesda, MD 20892-7924,...

  6. 77 FR 57099 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Resource.... Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute,...

  7. 77 FR 39716 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm. 7202, Bethesda, MD 20892, 301-435-0297... constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung,...

  8. 77 FR 63844 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Bio-Specimen... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  9. 77 FR 12856 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI Cardiovascular... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196,...

  10. 77 FR 1941 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Career... Officer, Office of Scentific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  11. 76 FR 29772 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Mentored Career...: Giuseppe Pintucci, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  12. 78 FR 19725 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Training in Lung... Joyce, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart, Lung,...

  13. 78 FR 14563 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI K Career... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  14. 77 FR 65568 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Regulation of Blood... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196,...

  15. 78 FR 9708 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee. Date... Person: Keary A Cope, Ph.D., Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  16. 78 FR 20670 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Hypoxia and... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206,...

  17. 77 FR 43099 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186, Bethesda, MD 20892-7924,...

  18. 76 FR 55077 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Translational..., Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive,...

  19. 78 FR 28229 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... of Committee: National Heart, Lung, and Blood Advisory Council. ] Date: June 19, 2013. Open: 8:00...

  20. 75 FR 8085 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Research Program... Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7178, Bethesda,...

  1. 75 FR 56548 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group Clinical Trials Review Committee. Date... Person: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  2. 75 FR 56552 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  3. 77 FR 48526 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute, Special Emphasis Panel, Biostatistics..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7190, Bethesda, MD 20892-7924,...

  4. 75 FR 29353 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... Person: Keary A Cope, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and...

  5. 76 FR 45843 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  6. 77 FR 59200 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. The meeting... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  7. 77 FR 24973 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; The Kidney in.../DERA, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge...

  8. 77 FR 76058 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Hispanic... Officer, Office of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge...

  9. 76 FR 3641 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Program Project in... Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7206, Bethesda,...

  10. 77 FR 14024 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Development... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7186,...

  11. 76 FR 58025 - National Heart, Lung and Blood Institute Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung and Blood Institute Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Gene Therapy... of Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  12. 76 FR 27068 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, SBIR Contract Review..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184, Bethesda, MD 20892-7924....

  13. 77 FR 76056 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI CARDIA Echo... Scientific Review/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 7184,...

  14. 76 FR 23827 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of....), notice is hereby given of a meeting of the National Heart, Lung, and Blood Advisory Council. ] The... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  15. 76 FR 62422 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, Clinical Trials Review Committee. Date... Person: Keary A Cope, Ph.D., Scientific Review Officer, Review Branch/DERA, National Heart, Lung,...

  16. 76 FR 64360 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Virtual Reality... Blood Institute Special Emphasis Panel, Virtual Reality Technologies for Research and Education...

  17. 78 FR 16860 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Side Effects of Transfusion and Cellular Therapies. Date: April 8, 2013. Time: 8:30 a.m. to 12:30 p.m. Agenda: To review...

  18. 77 FR 16844 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Resource-related Application in Congenital Heart Diseases (R24). Date: April 17, 2012. Time: 1 p.m. to 3 p.m. Agenda: To review... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of...

  19. 78 FR 63995 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Intermittent Hypoxia...: William J Johnson, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National...

  20. 77 FR 58402 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... programs and projects conducted by the National Heart, Lung, and Blood Institute, including consideration... Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research;...

  1. 76 FR 57061 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 9030, Bethesda, MD 20892, 301-435... Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung...

  2. 76 FR 19106 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 9030, Bethesda, MD 20892, 301-435-0080... Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung...

  3. 78 FR 22892 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  4. 76 FR 57066 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of...; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood...

  5. 78 FR 60299 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date... Person: Keary A. Cope, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA National...

  6. 76 FR 40923 - National Heart, Lung, and Blood Institute Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Reducing Emergency..., Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  7. 78 FR 7792 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of... Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National..., Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  8. 76 FR 11254 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  9. 75 FR 5090 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Science Moving.... Contact Person: William J Johnson, PhD, Scientific Review Officer, Review Branch/DERA, National...

  10. 77 FR 69870 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism...: Charles Joyce, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National Heart,...

  11. 77 FR 64818 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ....233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI...

  12. 75 FR 156 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-04

    ... Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases...: E9-31138] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and...

  13. 75 FR 9907 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Development of...

  14. 76 FR 72209 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Predoctoral Training..., (Telephone Conference Call). Contact Person: Stephanie L Constant, Ph.D., Scientific Review Officer,...

  15. 78 FR 16274 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel SBIR... 20892, (Telephone Conference Call). Contact Person: Kristin Goltry, Ph.D., Scientific Review...

  16. 76 FR 14674 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Emergency Medicine... 20814. Contact Person: Charles Joyce, PhD, Scientific Review Officer, Office of Scientific...

  17. 77 FR 66855 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Translational Programs..., Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Susan Wohler Sunnarborg, Ph.D.,...

  18. 76 FR 70154 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Life after Linkage.... Contact Person: YingYing Li-Smerin, MD, Ph.D., Scientific Review Officer, Office of Scientific...

  19. 78 FR 18995 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... ] Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Research... 22202. Contact Person: Keith A. Mintzer, Ph.D., Scientific Review Officer, Review Branch/DERA,...

  20. 75 FR 4092 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Technologies for In... Conference Call). Contact Person: Youngsuk Oh, PhD, Scientific Review Officer, Review Branch/DERA,...

  1. 78 FR 63483 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Atlas of Lung...., Washington, DC 20036. Contact Person: Stephanie L Constant, Ph.D., Scientific Review Officer, Office...

  2. 77 FR 21787 - National Heart, Lung, and Blood Institute: Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute: Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI Loan... Conference Call). Contact Person: Chang Sook Kim, Ph.D., Scientific Review Officer, Office of...

  3. 77 FR 55853 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; K23, K24, K25..., Conference Room 6, Bethesda, MD 20892. Contact Person: Stephanie J Webb, Ph.D., Scientific Review...

  4. 77 FR 64814 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Vascular... Drive, Potomac, MD 20854. Contact Person: Charles Joyce, Ph.D., Scientific Review Officer, Office...

  5. 77 FR 16246 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Omics and... 20814. Contact Person: Tony L Creazzo, Ph.D., Scientific Review Officer, Office of Scientific...

  6. 77 FR 44640 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Clinical Trials at the... Conference Call). Contact Person: Charles Joyce, Ph.D., Scientific Review Officer, Office of...

  7. 78 FR 30319 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Pathway to.... Contact Person: Giuseppe Pintucci, Ph.D., Scientific Review Officer, Office of Scientific...

  8. 75 FR 57971 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mentored Clinical... Highway, Arlington, VA 22202. Contact Person: Keith A. Mintzer, PhD, Scientific Review Officer,...

  9. 75 FR 70273 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, The Antihypertensive and Lipid-Lowering to Prevent Heart Attack Trial. Date: December 1, 2010. Time: 1:30 p.m. to 4 p.m... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of...

  10. 76 FR 29254 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group; NHLBI Institutional Training Mechanism..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924,...

  11. 78 FR 1864 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel Phase II Trials in Lung Disease. Date: February 1, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate...

  12. 76 FR 31617 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Utilization of a Human Lung Tissue Resource for Vascular Research. Date: June 23, 2011. Time: 8 a.m. to 5 p.m. Agenda:...

  13. 76 FR 59708 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI--Mentored.... Contact Person: Stephanie J Webb, PhD, Scientific Review Officer, Review Branch/DERA, National Heart,...

  14. 77 FR 37911 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed.... Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Phase II Trials in Lung Disease. Date: July 12, 2012. Time: 8:30 a.m. to 5:00 p.m. Agenda: To review and evaluate...

  15. 76 FR 71580 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Reducing the Impact of Hypertension in Low and Middle Income Countries. Date: December 6, 2011. Time: 8:30 a.m. to 5...

  16. 78 FR 66946 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  17. 75 FR 51828 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Heart Failure Clinical Trial. Date: September 3, 2010. Time: 1 p.m. to 3 p... Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the...

  18. 75 FR 52957 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed....), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Resource...

  19. 75 FR 28032 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI DNA... Heart, Lung, and Blood Institute Special Emphasis Panel, NHLBI DNA Resequencing and Genotyping (RS&G...; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood...

  20. 75 FR 61508 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of....837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  1. 77 FR 28612 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee National Heart, Lung, and Blood Institute Special Emphasis Panel; Early Cystic Fibrosis..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7189, Bethesda, MD 20892,...

  2. 75 FR 29356 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... of Committee: Heart, Lung, and Blood Initial Review Group, NHLBI Institutional Training Mechanism..., Lung, and Blood Institute, 6701 Rockledge Drive, Room 7196, Bethesda, MD 20892-7924....

  3. 78 FR 69430 - National Heart, Lung, and Blood Institute Amended; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute Amended; Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  4. 76 FR 15330 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  5. 78 FR 57168 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... and projects conducted by the National Heart, Lung, and Blood Institute, including consideration of....837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  6. 78 FR 10185 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed... privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; SBIR Topic...; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood...

  7. 75 FR 76478 - National Heart, Lung, and Blood Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Heart, Lung, and...

  8. 78 FR 54261 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., Ph.D., Director, National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Suite...

  9. Regional pulmonary perfusion following human heart-lung transplantation

    SciTech Connect

    Lisbona, R.; Hakim, T.S.; Dean, G.W.; Langleben, D.; Guerraty, A.; Levy, R.D. )

    1989-08-01

    Ventilation and perfusion scans were obtained in six subjects who had undergone heart-lung transplantation with consequent denervation of the cardiopulmonary axis. Two of the subjects had developed obliterative bronchiolitis, which is believed to be a form of chronic rejection. Their pulmonary function tests demonstrated airflow obstruction and their scintigraphic studies were abnormal. In the remaining four subjects without obstructive airways disease, ventilation and planar perfusion scans were normal. Single photon emission computed tomography imaging of pulmonary perfusion in these patients revealed a layered distribution of blood flow indistinguishable from that of normal individuals. It is concluded that neurogenic mechanisms have little influence on the pattern of local pulmonary blood flow at rest.

  10. 75 FR 50771 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... grant applications and the discussions could disclose confidential trade secrets or commercial property... applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; NHLBI...

  11. 75 FR 31796 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Atherosclerosis Risk in... Blood Institute Special Emphasis Panel, Atherosclerosis Risk in Communities (ARIC) Study--Central... Emphasis Panel, Atherosclerosis Risk in Communities (ARIC) Study--Coordinating Center. Date: June 24,...

  12. 76 FR 37132 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Heart, Lung, and Blood Institute, Special Emphasis Panel. Studies to Identify Genetic Determinants of... Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases...

  13. 76 FR 19103 - National Heart, Lung, and Blood Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of..., PhD, Director, National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart... Center for Sleep Disorders Research; 93.837, Heart and ] Vascular Diseases Research; 93.838,...

  14. 75 FR 33626 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Roy L White, PhD, Scientific Review Officer, Review Branch/DERA, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room...

  15. The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients

    SciTech Connect

    Higenbottam, T.; Jackson, M.; Woolman, P.; Lowry, R.; Wallwork, J.

    1989-07-01

    As a result of clinical heart-lung transplantation, the lungs are denervated below the level of the tracheal anastomosis. It has been questioned whether afferent vagal reinnervation occurs after surgery. Here we report the cough frequency, during inhalation of ultrasonically nebulized distilled water, of 15 heart-lung transplant patients studied 6 wk to 36 months after surgery. They were compared with 15 normal subjects of a similar age and sex. The distribution of the aerosol was studied in five normal subjects using /sup 99m/technetium diethylene triamine pentaacetate (/sup 99m/Tc-DTPA) in saline. In seven patients, the sensitivity of the laryngeal mucosa to instilled distilled water (0.2 ml) was tested at the time of fiberoptic bronchoscopy by recording the cough response. Ten percent of the aerosol was deposited onto the larynx and trachea, 56% on the central airways, and 34% in the periphery of the lung. The cough response to the aerosol was strikingly diminished in the patients compared with normal subjects (p less than 0.001), but all seven patients coughed when distilled water was instilled onto the larynx. As expected, the laryngeal mucosa of heart-lung transplant patients remains sensitive to distilled water. However, the diminished coughing when the distilled water is distributed by aerosol to the central airways supports the view that vagal afferent nerves do not reinnervate the lungs after heart-lung transplantation, up to 36 months after surgery.

  16. Heart lung transplantation in a patient with end stage lung disease due to common variable immunodeficiency

    PubMed Central

    Hill, A; Thompson, R; Wallwork, J; Stableforth, D

    1998-01-01

    The case history is presented of a patient with common variable immunodeficiency in whom heart lung transplantation has been carried out with success. Transplantation was the only long term therapeutic option in this patient due to the progressive respiratory failure resulting from bronchiectasis, emphysema, and granulomatous lung disease.

 PMID:9797766

  17. 78 FR 66754 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Cardiovascular Disease Model Resource Related Research Project. Date: December 4, 2013. Time: 11:00 a.m. to 1:30 p.m..., Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases...

  18. 78 FR 76849 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following...

  19. 77 FR 3479 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ..., Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood...: Melissa E Nagelin, Ph.D., Scientific Review Officer, Office of Scientific Review/DERA, National...

  20. 78 FR 33852 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... Heart, Lung, and Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... Blood Institute Special Emphasis Panel; Trauma and Hemostasis. Date: June 25, 2013. Time: 7:30 a.m. to 5... Jefferson Davis Highway, Arlington, VA 22202. Contact Person: Michael P Reilly, Ph.D., Scientific...

  1. 75 FR 36427 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ..., Lung, and Blood Institute Special Emphasis Panel, Career Enhancement Award for Stem Cell Research. Date... Research Project in National Biological Sample Data Repository. Date: July 7, 2010. Time: 11 a.m. to 2 p.m... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Resource Related...

  2. The Role of School Health Education in Preventing Heart, Lung, and Blood Diseases.

    ERIC Educational Resources Information Center

    Kolbe, Lloyd J.; Newman, Ian M.

    1984-01-01

    This article reviews the scope and dynamics of heart, lung, and blood diseases and explains the need for research on primary prevention programs for children. Suggestions for school health education programs that contribute to disease prevention are delineated. (Author/DF)

  3. 77 FR 5261 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Haptoglobin for Sickle Cell Disease. Date: February 24, 2012. Time: 12 p.m. to 1 p.m. Agenda: To review and evaluate contract.... 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases...

  4. A novel approach in extracorporeal circulation: individual, integrated, and interactive heart-lung assist (I3-Assist).

    PubMed

    Wagner, Georg; Schlanstein, Peter; Fiehe, Sandra; Kaufmann, Tim; Kopp, Rüdger; Bensberg, Ralf; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Arens, Jutta

    2014-04-01

    Extracorporeal life support (ECLS) is a well-established technique for the treatment of different cardiac and pulmonary diseases, e.g., congenital heart disease and acute respiratory distress syndrome. Additionally, severely ill patients who cannot be weaned from the heart-lung machine directly after surgery have to be put on ECLS for further therapy. Although both systems include identical components, a seamless transition is not possible yet. The adaption of the circuit to the patients' size and demand is limited owing to the components available. The project I³-Assist aims at a novel concept for extracorporeal circulation. To better match the patient's therapeutic demand of support, an individual number of one-size oxygenators and heat exchangers will be combined. A seamless transition between cardiopulmonary bypass and ECLS will be possible as well as the exchange of components during therapy to enhance circuit maintenance throughout long-term support. Until today, a novel oxygenator and heat exchanger along with a simplified manufacturing protocol have been established. The first layouts of the unit to allow the spill- and bubble-free connection and disconnection of modules as well as improved cannulas and a rotational pump are investigated using computational fluid dynamics. Tests were performed according to current guidelines in vitro and in vivo. The test results show the feasibility and potential of the concept.

  5. Paediatric heart failure research: role of the National Heart, Lung, and Blood Institute.

    PubMed

    Burns, Kristin M

    2015-08-01

    The National Heart, Lung, and Blood Institute, of the National Institutes of Health, is committed to supporting research in paediatric heart failure. The Institute's support of paediatric heart failure research includes both investigator-initiated grants and Institute initiatives. There were 107 funded grants in paediatric heart failure over the past 20 years in basic, translational and clinical research, technology development, and support of registries. Such research includes a broad diversity of scientific topics and approaches. The Institute also supports several initiatives for paediatric heart failure, including the Pediatric Circulatory Support Program, the Pumps for Kids, Infants, and Neonates (PumpKIN) Program, PediMACS, and the Pediatric Heart Network. This review article describes the National Heart, Lung, and Blood Institute's past, present, and future efforts to promote a better understanding of paediatric heart failure, with the ultimate goal of improving outcomes.

  6. Postoperative complications necessitating right lower lobectomy in a heart-lung transplant recipient with previous sternotomy.

    PubMed

    Diethrich, E B; Bahadir, I; Gordon, M; Maki, P; Warner, M G; Clark, R; Siever, J; Silverthorn, A

    1987-09-01

    Heart-lung transplantation for treatment of end-stage cardiopulmonary disease continues to be plagued by many problems. Three primary ones are the technical difficulties that can be encountered, particularly in those patients who have undergone previous cardiac operations, the additional restriction on donor availability imposed by the lack of satisfactory preservation techniques, and the need for lung size compatibility. Two of these difficulties and others surfaced postoperatively in a heart-lung transplant recipient who presented a series of unique operative and therapeutic challenges. A 42-year-old woman with chronic pulmonary hypertension and previous atrial septal defect repair underwent a heart-lung transplantation in August 1985. The operative procedure was expectedly complicated by bleeding from extensive mediastinal adhesions from the previous sternotomy and bronchial collateralization. Excessive chest tube drainage postoperatively necessitated reoperation to control bleeding from a right bronchial artery tributary. Phrenic nerve paresis, hepatomegaly, and marked abdominal distention caused persistent atelectasis and eventual right lower lobe collapse. Arteriovenous shunting and low oxygen saturation necessitated right lower lobectomy 15 days after transplantation, believed to be the first use of this procedure in a heart-lung graft recipient. Although oxygenation improved dramatically, continued ventilatory support led to tracheostomy. An intensive, psychologically oriented physical therapy program was initiated to access and retrain intercostal and accessory muscles. The tracheostomy cannula was removed after 43 days and gradual weaning from supplemental oxygen was accomplished. During this protracted recovery period, an episode of rejection was also encountered and successfully managed with steroid therapy. The patient continued to progress satisfactorily and was discharged 83 days after transplantation. She is well and active 20 months after discharge.

  7. Extracorporeal life support in lung and heart-lung transplantation for pulmonary hypertension in adults.

    PubMed

    Kortchinsky, Talna; Mussot, Sacha; Rezaiguia, Saïda; Artiguenave, Margaux; Fadel, Elie; Stephan, François

    2016-09-01

    After bilateral lung and heart-lung transplantation in adults with pulmonary hypertension, hemodynamic and oxygenation deficiencies are life-threatening complications that are increasingly managed with extracorporeal life support (ECLS). The primary aim of this retrospective study was to assess 30-day and 1-year survival rates in patients managed with vs without post-operative venoarterial ECLS in 2008-2013. The secondary endpoints were the occurrence rates of nosocomial infection, bleeding, and acute renal failure. Of the 93 patients with pulmonary hypertension who received heart-lung (n=29) or bilateral lung (n=64) transplants, 28 (30%) required ECLS a median of 0 [0-6] hours after surgery completion and for a median of 3.0 [2.0-8.5] days. Compared to ECLS patients, controls had higher survival at 30 days (95.0% vs 78.5%; P=.02) and 1 year (83% vs 64%; P=.005), fewer nosocomial infections (48% vs 79%; P=.0006), and fewer bleeding events (17% vs 43%; P=.008). The need for renal replacement therapy was not different between groups (11% vs 17%; P=.54). Venoarterial ECLS is effective in treating pulmonary graft dysfunction with hemodynamic failure after heart-lung or bilateral lung. However, ECLS use was associated with higher rates of infection and bleeding.

  8. [Reverse valves in the drive line of occlusion pumps in "heart-lung" machines].

    PubMed

    Pisarevskiĭ, A A; Tishechkin, Iu V; Baguk, G D; Matveev, Iu G; Karasev, A B

    1980-01-01

    An analysis of hydraulic cyclograms of perfusion blood-pumps (A. A. Pisarevski et al., 1970) and characteristics of polymeric main lines in artificial blood-circulation units (A. A. Pisarevski et al., 1971) suggested that a reverse-acting valve placed at the outlet of the pressure pump will decrease regurgitation into its elastic chamber at the moment when the cycle is completed: it will increase the occlusion pump discharge during contraction, or even more, will lessen the variable pressure component behind the pump. This was confirmed by the roller-pump test with or without a valve at the pump outlet. The article presents the test method, types and functional assessment of the valves tested and the design of a newly developed petal-slotted V-shaped valve. Its comparison with other valve designs showed the best hydraulic features.

  9. Super liquid-repellent gas membranes for carbon dioxide capture and heart-lung machines.

    PubMed

    Paven, Maxime; Papadopoulos, Periklis; Schöttler, Susanne; Deng, Xu; Mailänder, Volker; Vollmer, Doris; Butt, Hans-Jürgen

    2013-01-01

    In a gas membrane, gas is transferred between a liquid and a gas through a microporous membrane. The main challenge is to achieve a high gas transfer while preventing wetting and clogging. With respect to the oxygenation of blood, haemocompatibility is also required. Here we coat macroporous meshes with a superamphiphobic-or liquid repellent-layer to meet this challenge. The superamphiphobic layer consists of a fractal-like network of fluorinated silicon oxide nanospheres; gas trapped between the nanospheres keeps the liquid from contacting the wall of the membrane. We demonstrate the capabilities of the membrane by capturing carbon dioxide gas into a basic aqueous solution and in addition use it to oxygenate blood. Usually, blood tends to clog membranes because of the abundance of blood cells, platelets, proteins and lipids. We show that human blood stored in a superamphiphobic well for 24 h can be poured off without leaving cells or adsorbed protein behind.

  10. Outcome of the first successful heart-lung transplantation in the Baltic countries.

    PubMed

    Kubilius, Raimondas; Malakauskas, Kęstutis; Jankauskienė, Loreta; Jakuška, Povilas; Bolys, Ramūnas; Pociūtė, Evelina; Boguševičius, Vaidotas; Benetis, Rimantas

    2013-01-01

    Successful heart-lung complex transplantation was performed in a 48-year-old man. During the postoperative period, M. tuberculosis infection was diagnosed, and the treatment subsequently started. One year after, the patient was urgently hospitalized due to myocardial infarction. However, despite the best efforts, the patient died. Antituberculosis treatment is recommended to all the patients with confirmed active tuberculosis. Treatment of tuberculosis in transplant recipients is similar to that of the general population, with the exclusion of rifamycins in the regimen and longer duration of treatment.

  11. Two Cases of Late Shone Syndrome With Pulmonary Hypertension: Heart-Lung Transplant or Valve Surgery?

    PubMed

    Robich, Michael P; Stewart, Robert D; Zahka, Kenneth G; Krasuski, Richard A; Hanna, Mazen; Blackstone, Eugene H; Pettersson, Gosta B

    2016-01-01

    Two cases of Shone syndrome with severe mitral and aortic valve problems and pulmonary hypertension were referred for heart-lung transplantation. Severely elevated pulmonary vascular resistance (PVR) was confirmed as was severe periprosthetic mitral and aortic regurgitation. Based on the severity of the valve lesions in both patients, surgery was decided upon and undertaken. Both experienced early pulmonary hypertensive crises, one more than the other, that gradually subsided, followed by excellent recovery and reversal of pulmonary hypertension and PVR. These cases illustrate Braunwald's concept that pulmonary hypertension secondary to left-sided valve disease is reversible.

  12. Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy community.

    PubMed

    Tarantal, Alice F; Skarlatos, Sonia I

    2012-11-01

    The goals of the National Heart, Lung, and Blood Institute (NHLBI) Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to conduct gene transfer studies in monkeys to evaluate safety and efficiency; and to provide NHLBI-supported investigators with expertise, resources, and services to actively pursue gene transfer approaches in monkeys in their research programs. NHLBI-supported projects span investigators throughout the United States and have addressed novel approaches to gene delivery; "proof-of-principle"; assessed whether findings in small-animal models could be demonstrated in a primate species; or were conducted to enable new grant or IND submissions. The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field.

  13. Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group.

    PubMed

    Buxton, Denis B; Lee, Stephen C; Wickline, Samuel A; Ferrari, Mauro

    2003-12-02

    Recent rapid advances in nanotechnology and nanoscience offer a wealth of new opportunities for diagnosis and therapy of cardiovascular, pulmonary, and hematologic diseases and sleep disorders. To review the challenges and opportunities offered by these nascent fields, the National Heart, Lung, and Blood Institute convened a Working Group on Nanotechnology. Working Group participants discussed the various aspects of nanotechnology and its applications to heart, lung, blood, and sleep (HLBS) diseases. This report summarizes their discussions according to scientific opportunities, perceived needs and barriers, specific disease examples, and recommendations on facilitating research in the field. An overarching recommendation of the Working Group was to focus on translational applications of nanotechnology to solve clinical problems. The Working Group recommended the creation of multidisciplinary research centers capable of developing applications of nanotechnology and nanoscience to HLBS research and medicine. Centers would also disseminate technology, materials, and resources and train new investigators. Individual investigators outside these centers should be encouraged to conduct research on the application of nanotechnology to biological and clinical problems. Pilot programs and developmental research are needed to attract new investigators and to stimulate creative, high-impact research. Finally, encouragement of small businesses to develop nanotechnology-based approaches to clinical problems was considered important.

  14. National Heart, Lung, and Blood Institute and the translation of cardiovascular discoveries into therapeutic approaches.

    PubMed

    Galis, Zorina S; Black, Jodi B; Skarlatos, Sonia I

    2013-04-26

    The molecular causes of ≈4000 medical conditions have been described, yet only 5% have associated therapies. For decades, the average time for drug development through approval has taken 10 to 20 years. In recent years, the serious challenges that confront the private sector have made it difficult to capitalize on new opportunities presented by advances in genomics and cellular therapies. Current trends are disturbing. Pharmaceutical companies are reducing their investments in research, and biotechnology companies are struggling to obtain venture funds. To support early-stage translation of the discoveries in basic science, the National Institutes of Health and the National Heart, Lung, and Blood Institute have developed new approaches to facilitating the translation of basic discoveries into clinical applications and will continue to develop a variety of programs that create teams of academic investigators and industry partners. The goal of these programs is to maximize the public benefit of investment of taxpayer dollars in biomedical research and to lessen the risk required for industry partners to make substantial investments. This article highlights several examples of National Heart, Lung, and Blood Institute-initiated translational programs and National Institutes of Health translational resources designed to catalyze and enable the earliest stages of the biomedical product development process. The translation of latest discoveries into therapeutic approaches depends on continued federal funding to enhance the early stages of the product development process and to stimulate and catalyze partnerships between academia, industry, and other sources of capital.

  15. Clinical Outcomes of Heart-Lung Transplantation: Review of 10 Single-Center Consecutive Patients

    PubMed Central

    Yun, Jae Kwang; Choi, Se Hoon; Park, Seung-Il

    2016-01-01

    Background Heart-lung transplantation (HLT) has provided hope to patients with end-stage lung disease and irreversible heart dysfunction. We reviewed the clinical outcomes of 10 patients who underwent heart-lung transplantation at Asan Medical Center. Methods Between July 2010 and August 2014, a total of 11 patients underwent HLT at Asan Medical Center. After excluding one patient who underwent concomitant liver transplantation, 10 patients were enrolled in our study. We reviewed the demographics of the donors and the recipients’ baseline information, survival rate, cause of death, and postoperative complications. All patients underwent follow-up, with a mean duration of 26.1±16.7 months. Results Early death occurred in two patients (20%) due to septic shock. Late death occurred in three patients (38%) due to bronchiolitis obliterans (n=2) and septic shock (n=1), although these patients survived for 22, 28, and 42 months, respectively. The actuarial survival rates at one year, two years, and three years after HLT were 80%, 67%, and 53%, respectively. Conclusion HLT is a procedure that is rarely performed in Korea, even in medical centers with large heart and lung transplant programs. In order to achieve acceptable clinical outcomes, it is critical to carefully choose the donor and the recipient and to be certain that all aspects of the transplant procedure are planned in advance with the greatest care. PMID:27298792

  16. The Relationship between National Heart, Lung, and Blood Institute Weight Guidelines and Concurrent Medical Costs in a Manufacturing Population.

    ERIC Educational Resources Information Center

    Wang, Feifei; Schultz, Alyssa B.; Musich, Shirley; McDonald, Tim; Hirschland, David; Edington, Dee W.

    2003-01-01

    Explored the relationship between the 1998 National Heart, Lung, and Blood Institute (NHLBI) weight guidelines and concurrent medical costs among 177,971 employees, retirees, and adult dependents from a nationwide manufacturing corporation. Results indicated that the six weight groups defined by the NHLBI guidelines were consistent with concurrent…

  17. Increasing the Number of Competing Awards at the National Heart, Lung, and Blood Institute: Projections of a Model.

    ERIC Educational Resources Information Center

    Roth, Carl A.; Lenfant, Claude

    1991-01-01

    The National Heart, Lung, and Blood Institute (NHLBI) has begun funding longer research award terms, limiting the number of projects to be funded. A model was developed to assess alternative research funding policies that might allow NHLBI to support more competing awards. Findings and implications for research stability are reported. (Author/MSE)

  18. [Logistic, technic and postoperative complications of lung and heart-lung transplantations].

    PubMed

    Bonnette, P

    2010-02-01

    In France, the "Agence de la biomédecine" distributes lung grafts. "Ideal" criteria for lung donor selection are not always respected, driven by the scarcity of suitable donor lungs (10% deaths while waiting). In single lung transplantation, three anastomoses are performed (bronchus near the lobar carina, pulmonary artery, left atrium). For double lung transplantation (twice as frequent around the world), two single lung transplantations are successively performed through two separate anterolateral thoracotomies, often without cardiopulmonary bypass. Heart lung transplantations are now rare (2% around the world). Postoperative mortality has improved (between 10 and 15%): less severe primary graft dysfunctions, treatable with ECMO, fewer bronchial complications, improvement in the diagnosis of hyperacute humoral rejection, improvement in antiviral prophylaxis.

  19. Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm

    PubMed Central

    Dagdeviren, Canan; Yang, Byung Duk; Su, Yewang; Tran, Phat L.; Joe, Pauline; Anderson, Eric; Xia, Jing; Doraiswamy, Vijay; Dehdashti, Behrooz; Feng, Xue; Lu, Bingwei; Poston, Robert; Khalpey, Zain; Ghaffari, Roozbeh; Huang, Yonggang; Slepian, Marvin J.; Rogers, John A.

    2014-01-01

    Here, we report advanced materials and devices that enable high-efficiency mechanical-to-electrical energy conversion from the natural contractile and relaxation motions of the heart, lung, and diaphragm, demonstrated in several different animal models, each of which has organs with sizes that approach human scales. A cointegrated collection of such energy-harvesting elements with rectifiers and microbatteries provides an entire flexible system, capable of viable integration with the beating heart via medical sutures and operation with efficiencies of ∼2%. Additional experiments, computational models, and results in multilayer configurations capture the key behaviors, illuminate essential design aspects, and offer sufficient power outputs for operation of pacemakers, with or without battery assist. PMID:24449853

  20. Differential effects of chronic cyanide intoxication on heart, lung and pancreatic tissues.

    PubMed

    Okolie, N P; Osagie, A U

    2000-06-01

    The histotoxic effects of chronic cyanide insult on heart, lung and pancreatic tissues, and some corroborative enzyme and metabolite changes were studied in New Zealand White rabbits using colorimetric, enzymatic and histochemical methods. Two groups of rabbits were fed for 10 months on either pure growers mash or grower mash +702 ppm inorganic cyanide. There were no significant differences in time-course profiles of serum amylase and fasting blood glucose between the cyanide-fed group and control. Pancreatic islet and heart histologies showed no pathological changes, and there were no significant differences in both serum and heart aspartate transaminase activities between the two groups. However, there were significant decreases (P<0.01) in alkaline phosphatase activity in the lungs of the cyanide-fed group, with corresponding significant (P<0.05) increases in the serum activity of the enzyme. Histological examination of lung tissue of the cyanide-treated rabbits revealed focal areas of pulmonary oedema and necrosis. These results suggest the existence of variabilities in tissue susceptibilities to the toxic effect of chronic cyanide exposure. It would appear that chronic cyanide exposure may not predispose to diabetes in the presence of adequate protein intake.

  1. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.

    PubMed

    Jarjour, Nizar N; Erzurum, Serpil C; Bleecker, Eugene R; Calhoun, William J; Castro, Mario; Comhair, Suzy A A; Chung, Kian Fan; Curran-Everett, Douglas; Dweik, Raed A; Fain, Sean B; Fitzpatrick, Anne M; Gaston, Benjamin M; Israel, Elliot; Hastie, Annette; Hoffman, Eric A; Holguin, Fernando; Levy, Bruce D; Meyers, Deborah A; Moore, Wendy C; Peters, Stephen P; Sorkness, Ronald L; Teague, W Gerald; Wenzel, Sally E; Busse, William W

    2012-02-15

    The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.

  2. Heart-lung vs. double-lung transplantation for idiopathic pulmonary arterial hypertension.

    PubMed

    Hill, Charles; Maxwell, Bryan; Boulate, David; Haddad, Francois; Ha, Richard; Afshar, Kamyar; Weill, David; Dhillon, Gundeep S

    2015-12-01

    Patients with idiopathic pulmonary arterial hypertension (IPAH) have improved survival after heart-lung transplantation (HLT) and double-lung transplantation (DLT). However, the optimal procedure for patients with IPAH undergoing transplantation remains unclear. We hypothesized that critically ill IPAH patients, defined by admission to the intensive care units (ICU), would demonstrate improved survival with HLT vs. DLT. All adult IPAH patients (>18 yr) in the Scientific Registry of Transplant Recipients (SRTR) database, who underwent either HLT or DLT between 1987 and 2012, were included. Baseline characteristics, survival, and adjusted survival were compared between the HLT and DLT groups. Similar analyses were performed for the subgroups as defined by the recipients' hospitalization status. A total of 928 IPAH patients (667 DLT, 261 HLT) were included in this analysis. The HLT recipients were younger, more likely to be admitted to the ICU, and have had their transplant in previous eras. Overall, the adjusted survivals after HLT or DLT were similar. For recipients who were hospitalized in the ICU, DLT was associated with worse outcomes (HR 1.827; 95% CI 1.018-3.279). In IPAH patients, the overall survival after HLT or DLT is comparable. HLT may provide improved outcomes in critically ill IPAH patients admitted to the ICU at time of transplantation.

  3. [Assisted circulation with the heart-lung machine after cardiosurgical interventions: one year's experience with intra-aortal counter-pulsation with the heart-lung machine after cardiosurgical operations is reported (author's transl)].

    PubMed

    Reichart, B; Kemkes, B; Kreuzer, E; Klinner, W; Holtz, J

    1978-02-17

    In the period from September 1976 to 1977, aortic or mitral valve replacement was performed in 84 and 34 patients respectively. Cardiogenic shock occurred during or immediately after the operation in 3 and 2 patients respectively (= 8.8% and 2.4%). In spite of the use of intra-aortal counter-pulsation, none of the patients survived the acute event. During the same period, 8 (= 5%) out of 113 patients who had undergone coronary surgery needed intra-aortal counter-pulsation. 4 of them survived the acute left heart failure and at the present time are clinically healthy (N.Y. Heart Association Class II).

  4. Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research.

    PubMed

    Pasquali, Sara K; Jacobs, Jeffrey P; Farber, Gregory K; Bertoch, David; Blume, Elizabeth D; Burns, Kristin M; Campbell, Robert; Chang, Anthony C; Chung, Wendy K; Riehle-Colarusso, Tiffany; Curtis, Lesley H; Forrest, Christopher B; Gaynor, William J; Gaies, Michael G; Go, Alan S; Henchey, Paul; Martin, Gerard R; Pearson, Gail; Pemberton, Victoria L; Schwartz, Steven M; Vincent, Robert; Kaltman, Jonathan R

    2016-04-05

    The National Heart, Lung, and Blood Institute convened a working group in January 2015 to explore issues related to an integrated data network for congenital heart disease research. The overall goal was to develop a common vision for how the rapidly increasing volumes of data captured across numerous sources can be managed, integrated, and analyzed to improve care and outcomes. This report summarizes the current landscape of congenital heart disease data, data integration methodologies used across other fields, key considerations for data integration models in congenital heart disease, and the short- and long-term vision and recommendations made by the working group.

  5. Point-of-Care Technologies for the Advancement of Precision Medicine in Heart, Lung, Blood, and Sleep Disorders

    PubMed Central

    Jamieson, Brian G.; Chui, Chi On; Mao, Yufei; Shin, Kyeong-Sik; Huang, Tony Jun; Huang, Po-Hsun; Ren, Liqiang; Adhikari, Bishow; Chen, Jue; Iturriaga, Erin

    2016-01-01

    The commercialization of new point of care technologies holds great potential in facilitating and advancing precision medicine in heart, lung, blood, and sleep (HLBS) disorders. The delivery of individually tailored health care to a patient depends on how well that patient’s health condition can be interrogated and monitored. Point of care technologies may enable access to rapid and cost-effective interrogation of a patient’s health condition in near real time. Currently, physiological data are largely limited to single-time-point collection at the hospital or clinic, whereas critical information on some conditions must be collected in the home, when symptoms occur, or at regular intervals over time. A variety of HLBS disorders are highly dependent on transient variables, such as patient activity level, environment, time of day, and so on. Consequently, the National Heart Lung and Blood Institute sponsored a request for applications to support the development and commercialization of novel point-of-care technologies through small businesses (RFA-HL-14-011 and RFA-HL-14-017). Three of the supported research projects are described to highlight particular point-of-care needs for HLBS disorders and the breadth of emerging technologies. While significant obstacles remain to the commercialization of such technologies, these advancements will be required to achieve precision medicine. PMID:27602308

  6. Strategic Transformation of Population Studies: Recommendations of the Working Group on Epidemiology and Population Sciences From the National Heart, Lung, and Blood Advisory Council and Board of External Experts

    PubMed Central

    Roger, Véronique L.; Boerwinkle, Eric; Crapo, James D.; Douglas, Pamela S.; Epstein, Jonathan A.; Granger, Christopher B.; Greenland, Philip; Kohane, Isaac; Psaty, Bruce M.

    2015-01-01

    In 2013, the National Heart, Lung, and Blood Institute assembled a working group on epidemiology and population sciences from its Advisory Council and Board of External Experts. The working group was charged with making recommendations to the National Heart, Lung, and Blood Advisory Council about how the National Heart, Lung, and Blood Institute could take advantage of new scientific opportunities and delineate future directions for the epidemiology of heart, lung, blood, and sleep diseases. Seven actionable recommendations were proposed for consideration. The themes included 1) defining the compelling scientific questions and challenges in population sciences and epidemiology of heart, lung, blood, and sleep diseases; 2) developing methods and training mechanisms to integrate “big data” science into the practice of epidemiology; 3) creating a cohort consortium and inventory of major studies to optimize the efficient use of data and specimens; and 4) fostering a more open, competitive approach to evaluating large-scale longitudinal epidemiology and population studies. By building on the track record of success of the heart, lung, blood, and sleep cohorts to leverage new data science opportunities and encourage broad research and training partnerships, these recommendations lay a strong foundation for the transformation of heart, lung, blood, and sleep epidemiology. PMID:25743324

  7. Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study

    PubMed Central

    NEOGI, TUHINA; ELLISON, R. CURTIS; HUNT, STEVEN; TERKELTAUB, ROBERT; FELSON, DAVID T.; ZHANG, YUQING

    2009-01-01

    Objective To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. (J Rheumatol First Release Nov 15 2008; doi:10.3899/jrheum.080646) PMID:19012359

  8. The in vivo effect of different bedding materials on the antioxidant levels of rat heart, lung and liver tissue.

    PubMed

    Potgieter, F J; Wilke, P I; van Jaarsveld, H; Alberts, D W

    1996-03-01

    Several experimental effects due to wood-derived bedding have been reported. Female Sprague Dawley rats were kept on pine shavings, eucalyptus pulp, vermiculite and in wire-bottomed cages without bedding for 14 days whereafter normal values for the antioxidants ascorbic acid and reduced glutathione (G-SH) in rat heart lung and liver tissue were determined and compared. Statistically significant differences were observed for lung G-SH between pine shavings and eucalyptus pulp (p < 0.0183), and heart G-SH between vermiculite and eucalyptus pulp (p < 0.0948). The highest levels of liver G-SH were obtained using pine shavings compared to vermiculite (p < 0.0001), eucalyptus pulp (p < 0.0002) and wire floor (p < 0.0001). Statistically significant differences in ascorbic acid concentrations could only be described between the wire-bottomed cages and eucalyptus pulp (p < 0.0333) for lung tissue and between pine shavings and eucalyptus pulp for liver tissue (p < 0.042). Although no statistically significant differences were observed in heart ascorbic acid levels between the different bedding applications, the concentration obtained using vermiculite was approximately 50% higher than that observed with the other materials. Pine shavings, eucalyptus pulp and wire floors demonstrated virtually the same heart tissue ascorbic acid levels. It was thus demonstrated that bedding material can alter the tissue antioxidant concentration of laboratory animals, limiting the comparison of this type of result between institutions to those using identical environmental conditions.

  9. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

    PubMed

    Rudy, Yoram; Ackerman, Michael J; Bers, Donald M; Clancy, Colleen E; Houser, Steven R; London, Barry; McCulloch, Andrew D; Przywara, Dennis A; Rasmusson, Randall L; Solaro, R John; Trayanova, Natalia A; Van Wagoner, David R; Varró, András; Weiss, James N; Lathrop, David A

    2008-09-09

    The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of cardiologists, cardiac electrophysiologists, cell biophysicists, and computational modelers on August 20 and 21, 2007, in Washington, DC, to advise the NHLBI on new research directions needed to develop integrative approaches to elucidate human cardiac function. The workshop strove to identify limitations in the use of data from nonhuman animal species for elucidation of human electromechanical function/activity and to identify what specific information on ion channel kinetics, calcium handling, and dynamic changes in the intracellular/extracellular milieu is needed from human cardiac tissues to develop more robust computational models of human cardiac electromechanical activity. This article summarizes the workshop discussions and recommendations on the following topics: (1) limitations of animal models and differences from human electrophysiology, (2) modeling ion channel structure/function in the context of whole-cell electrophysiology, (3) excitation-contraction coupling and regulatory pathways, (4) whole-heart simulations of human electromechanical activity, and (5) what human data are currently needed and how to obtain them. The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm.

  10. Development of a reflected optical fiber system for measuring oxygen saturation in an integrated artificial heart-lung system.

    PubMed

    Yasuda, Toshitaka; Saito, Tomohiko; Kihara, Tatsuya; Takatani, Setsuo; Funakubo, Akio

    2008-03-01

    The purpose of this study was to develop a blood oxygen saturation (OS) monitoring system for use with an integrated artificial heart-lung system (IAHLS). The OS monitoring system consists of two paired optical fiber probes (OFPs) and a measurement system. To investigate the effect of the OFP configuration and incident light wavelength on the relationship between OS and the reflectance ratio for wavelengths of 810 and 645 nm, we performed theoretical analyses of the relationship between OS and R810/R645 using a diffusion equation. The prototype OFP located on the blood outlet port of our IAHLS housing was evaluated using an in vitro test. An OS range of 65-100% was adjusted to supply oxygen and nitrogen gas to the IAHLS. The blood flow rate was maintained at 3 L/min by the rotational speed of an impeller in the IAHLS. The OS-corrected blood from the IAHLS was measured using a commercial gas analyzer. The correlation coefficients (r(2)) between the theoretical ratio of R810/R645 and OS, and between measured OS and the reflectance ratio of R810/R645 were 0.97 and 0.78, respectively. In conclusion, we confirmed that the development of this oximetry system is applicable for IAHLS.

  11. 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.

    PubMed

    Spitalnik, Steven L; Triulzi, Darrell; Devine, Dana V; Dzik, Walter H; Eder, Anne F; Gernsheimer, Terry; Josephson, Cassandra D; Kor, Daryl J; Luban, Naomi L C; Roubinian, Nareg H; Mondoro, Traci; Welniak, Lisbeth A; Zou, Shimian; Glynn, Simone

    2015-09-01

    On March 25 and 26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the National Institutes of Health (NIH) campus in Bethesda, Maryland, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5 to 10 years and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three "classical" transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Before the meeting, four working groups, one for each area, prepared five major questions for discussion along with a list of five to 10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in keynote lectures, small-group breakout sessions, and large-group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine.

  12. 2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine Symposium

    PubMed Central

    Spitalnik, Steven L.; Triulzi, Darrell; Devine, Dana V.; Dzik, Walter H.; Eder, Anne F.; Gernsheimer, Terry; Josephson, Cassandra D.; Kor, Daryl J.; Luban, Naomi L. C.; Roubinian, Nareg H.; Mondoro, Traci; Welniak, Lisbeth A.; Zou, Shimian; Glynn, Simone

    2015-01-01

    On March 25-26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the NIH campus in Bethesda, MD, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5-10 years, and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three “classical” transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Prior to the meeting, four Working Groups, one for each area, prepared five major questions for discussion along with a list of 5-10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in Keynote lectures, small group breakout sessions, and large group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine. PMID:26260861

  13. Chocolate Consumption is Inversely Associated with Prevalent Coronary Heart Disease: The National Heart, Lung, and Blood Institute Family Heart Study

    PubMed Central

    Djoussé, Luc; Hopkins, Paul N.; North, Kari E.; Pankow, James S.; Arnett, Donna K.; Ellison, R. Curtis

    2010-01-01

    Background and Aims Epidemiologic studies have suggested beneficial effects of flavonoids on cardiovascular disease. Cocoa and particularly dark chocolate are rich in flavonoids and recent studies have demonstrated blood pressure lowering effects of dark chocolate. However, limited data are available on the association of chocolate consumption and the risk of coronary heart disease (CHD). We sought to examine the association between chocolate consumption and prevalent CHD. Methods We studied in a cross-sectional design 4,970 participants aged 25 to 93 years who participated in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Chocolate intake was assessed through a semi-quantitative food frequency questionnaire. We used generalized estimating equations to estimate adjusted odds ratios. Results Compared to subjects who did not report any chocolate intake, odds ratios (95% CI) for CHD were 1.01 (0.76-1.37), 0.74 (0.56-0.98), and 0.43 (0.28-0.67) for subjects consuming 1-3 times/month, 1-4 times/week, and 5+ times/week, respectively (p for trend <0.0001) adjusting for age, sex, family CHD risk group, energy intake, education, non-chocolate candy intake, linolenic acid intake, smoking, alcohol intake, exercise, and fruit and vegetables. Consumption of non-chocolate candy was associated with a 49% higher prevalence of CHD comparing 5+/week vs. 0/week [OR=1.49 (0.96-2.32)]. Conclusions These data suggest that consumption of chocolate is inversely related with prevalent CHD in a general population. PMID:20858571

  14. Registry of the Japanese society of lung and heart-lung transplantation: the official Japanese lung transplantation report 2012.

    PubMed

    Oto, Takahiro; Okada, Yoshinori; Bando, Toru; Minami, Masato; Shiraishi, Takeshi; Nagayasu, Takeshi; Chida, Masayuki; Okumura, Meinoshin; Date, Hiroshi; Miyoshi, Shinichiro; Kondo, Takashi

    2013-04-01

    The Japanese Organ Transplant Law was amended, and the revised law took effect in July 2010 to overcome extreme donor shortage and to increase the availability of donor organs from brain-dead donors. It is now possible to procure organs from children. The year 2011 was the first year that it was possible to examine the results of this first extensive revision of the Japanese Organ Transplant Law, which took effect in 1997. Currently, seven transplant centers, including Tohoku, Dokkyo, Kyoto, Osaka, Okayama, Fukuoka and Nagasaki Universities, are authorized to perform lung transplantation in Japan, and by the end of 2011, a total of 239 lung transplants had been performed. The number of transplants per year and the ratio of brain-dead donor transplants increased dramatically after the revision of the Japanese Organ Transplant Law. The survival rates for lung transplant recipients registered with the Japanese Society for Lung and Heart-lung Transplantation were 93.3 % at 1 month, 91.5 % at 3 months, 86.3 % at 1 year, 79.0 % at 3 years, and 73.1 % at 5 years. The survival curves for brain-dead donor and living-donor lung transplantation were similar. The survival outcomes for both brain-dead and living-donor lung transplants were better than those reported by the International Society for Heart and Lung Transplantation. However, donor shortage remains a limitation of lung transplantation in Japan. The lung transplant centers in Japan should continue to make a special effort to save critically ill patients waiting for lung transplantation.

  15. Blood cyclosporin concentrations and the short-term risk of lung rejection following heart-lung transplantation.

    PubMed Central

    Best, N G; Trull, A K; Tan, K K; Hue, K L; Spiegelhalter, D J; Gore, S M; Wallwork, J

    1992-01-01

    1. The relationship between blood cyclosporin concentration (CyACb) and a patient's risk of organ rejection following heart-lung (HL) transplantation was investigated. 2. Longitudinal data were collected for 90 days post-operation for 31 HL transplant recipients. Following exploratory analysis, a multiple logistic regression model with a binary outcome variable representing presence or absence of lung rejection (as defined on biopsy findings and/or intention to treat) in the next 5 days was fitted to the data. 3. A significant interaction between time post-transplant and CyACb was found. During weeks 1-3, the relative risk (RR) of rejection per unit increase in log(e) (5-day mean CyACb) was reduced: RR = 0.29, 95% confidence interval (CI) = (0.12, 0.72). After 3 post-operative weeks, this trend was reversed: RR = 1.61, 95% CI = (0.96, 2.70). Increases in cyclosporin dose (CyAD) and in coefficient of variation (CV) for both CyAD and CyACb over the previous 10 days significantly increased the risk of rejection: RR per unit increase in log(e) (5-day mean CyAD) = 2.72, 95% CI = (1.18, 6.25); RR per increase of 10% (i.e. from, say, 20% to 30%) in the CV for CyAD = 1.20, 95% CI = (1.07, 1.36); RR if the CV for CyACb > 40% = 1.51, 95% CI = (1.01, 2.27). Administration of high dose steroids in the previous 5 days was found to protect against further rejection: RR if steroid treatment was given = 0.23, 95% CI = (0.13, 0.38).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1493084

  16. Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats

    PubMed Central

    Lei, Shaoqing; Liu, Yanan; Liu, Huimin; Yu, Hong; Wang, Hui

    2012-01-01

    Purpose Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of the major sources of ROS production in diabetes. We, therefore, examined the possibility that NADPH oxidase activation is increased in various tissues, and that the antioxidant N-acetylcysteine (NAC) may have tissue specific effects on NADPH oxidase and tissue antioxidant status in diabetes. Materials and Methods Control (C) and streptozotocin-induced diabetic (D) rats were treated either with NAC (1.5 g/kg/day) orally or placebo for 4 weeks. The plasma, heart, lung, liver, kidney were harvested immediately and stored for biochemical or immunoblot analysis. Results levels of free 15-F2t-isoprostane were increased in plasma, heart, lung, liver and kidney tissues in diabetic rats, accompanied with significantly increased membrane translocation of the NADPH oxidase subunit p67phox in all tissues and increased expression of the membrane-bound subunit p22phox in heart, lung and kidney. The tissue antioxidant activity in lung, liver and kidney was decreased in diabetic rats, while it was increased in heart tissue. NAC reduced the expression of p22phox and p67phox, suppressed p67phox membrane translocation, and reduced free 15-F2t-isoprostane levels in all tissues. NAC increased antioxidant activity in liver and lung, but did not significantly affect antioxidant activity in heart and kidney. Conclusion The current study shows that NAC inhibits NADPH oxidase activation in diabetes and attenuates tissue oxidative damage in all organs, even though its effects on antioxidant activity are tissue specific. PMID:22318816

  17. [The results of experimental study of six-hour heart-lung preservation by autoperfusion method--its evaluation of optimal conditions and lung function after preservation].

    PubMed

    Matsuoka, M; Makino, S; Hattori, R; Imura, M; Higashi, K; Morimoto, T; Yada, I; Namikawa, S; Yuasa, H; Kusagawa, M

    1989-04-01

    Up to date, it has been reported that the maintenance of ideal function of the preserved lungs were much more difficult than that of the hearts in heart-lung preservation. In this communication the authors have reported the results of experimental study for optimal conditions for preserving better function of the lungs by autoperfusion method by means of heart-lung preparation using 43 dogs. In this study the conditions of the preservation were fixed as following: perfusing blood temperature 29 degrees C, blood flow 30 ml/kg/min., FiO2 30%, FiCO2 5%, tidal volume 15 ml/kg, ventilation rate 10/min., and PEEP 5 cmH2O. Glucose-Insulin-Potassium (0.03 gm., 0.05 U., 0.02 mEq/kg/hr. respectively) were administered continuously by an infusion pump. The results showed that extravascular lung water contents after 6 hours of preservation was 0.79 (mean) +/- 0.01 (SD), which was increased only 1% over than the control group: 0.78 +/- 0.01. There was no significant difference of static lung compliance in two groups: the preserved group was 0.47 +/- 0.02 ml/gm.cmH2O compared to 0.51 +/- 0.06 in the control group. These results suggest that the autoperfusion method on our preserving conditions seems to be very promising and very effective to keep much better condition of the lungs in heart-lung preservation.

  18. Future directions for cardiovascular disease comparative effectiveness research: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

    PubMed

    Hlatky, Mark A; Douglas, Pamela S; Cook, Nakela L; Wells, Barbara; Benjamin, Emelia J; Dickersin, Kay; Goff, David C; Hirsch, Alan T; Hylek, Elaine M; Peterson, Eric D; Roger, Véronique L; Selby, Joseph V; Udelson, James E; Lauer, Michael S

    2012-08-14

    Comparative effectiveness research (CER) aims to provide decision makers with the evidence needed to evaluate the benefits and harms of alternative clinical management strategies. CER has become a national priority, with considerable new research funding allocated. Cardiovascular disease is a priority area for CER. This workshop report provides an overview of CER methods, with an emphasis on practical clinical trials and observational treatment comparisons. The report also details recommendations to the National Heart, Lung, and Blood Institute for a new framework for evidence development to foster cardiovascular CER, and specific studies to address 8 clinical issues identified by the Institute of Medicine as high priorities for cardiovascular CER.

  19. Cardiovascular genomics, personalized medicine, and the National Heart, Lung, and Blood Institute: part I: the beginning of an era.

    PubMed

    O'Donnell, Christopher J; Nabel, Elizabeth G

    2008-10-01

    The inaugural issue of Circulation: Cardiovascular Genetics arrives at a remarkable time in the history of genetic research and cardiovascular medicine. Despite tremendous progress in knowledge gained, cardiovascular disease(CVD) remains the leading cause of death in the United States,1 and it has overcome infectious diseases as the leading cause of death worldwide.2 In addition, rates of CVD remain higher in black and Hispanic populations in the United States.1 The recent Strategic Plan of the National Heart, Lung,and Blood Institute (NHLBI) emphasizes research areas to fill the significant knowledge gaps needed to improve the diagnosis,treatment, and control of known risk factors and clinically apparent disease. Simultaneously, the NHLBI Strategic Plan recognizes a tremendous opportunity that is available for use of genetic and genomic research to generate new knowledge that might reduce the morbidity and mortality from CVD in US populations.3 Public availability of vast amounts of detailed sequence information about the human genome, completed sequence data on dozens of other animal genomes, and private sector development of high-throughput genetic technologies has transformed in a few short years the conduct of cardiovascular genetics and genomics research from a primary focus on mendelian disorders to a current emphasis on genome-wide association studies (GWAS; Figure1). In this review, we describe the rationale for the current emphasis on large-scale genomic studies, summarize the evolving approaches and progress to date, and identify immediate-term research needs. The National Institutes of Health (NIH) and the NHLBI are supporting a portfolio of large-scale genetic and genomic programs in diverse US populations with the longer-term objective of translating knowledge into the prediction, prevention, and preemption of CVD, as well as lung, sleep, and blood disorders. Underlying this portfolio is a strong commitment to make available participant-level data and

  20. National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce

    PubMed Central

    Duncan, Gregg A.; Lockett, Angelia; Villegas, Leah R.; Almodovar, Sharilyn; Gomez, Jose L.; Flores, Sonia C.; Tigno, Xenia T.

    2016-01-01

    Rationale: Committed to its mission of conducting and supporting research that addresses the health needs of all sectors of the nation's population, the Division of Lung Diseases, National Heart, Lung, and Blood Institute of the National Institutes of Health (NHLBI/NIH) seeks to identify issues that impact the training and retention of underrepresented individuals in the biomedical research workforce. Objectives: Early-stage investigators who received grant support through the NIH Research Supplements to Promote Diversity in Health Related Research Program were invited to a workshop held in Bethesda, Maryland in June, 2015, in order to (1) assess the effectiveness of the current NHLBI diversity program, (2) improve its strategies towards achieving its goal, and (3) provide guidance to assist the transition of diversity supplement recipients to independent NIH grant support. Methods: Workshop participants participated in five independent focus groups to discuss specific topics affecting underrepresented individuals in the biomedical sciences: (1) Socioeconomic barriers to success for diverse research scientists; (2) role of the academic research community in promoting diversity; (3) life beyond a research project grant: non–primary investigator career paths in research; (4) facilitating career development of diverse independent research scientists through NHLBI diversity programs; and (5) effectiveness of current NHLBI programs for promoting diversity of the biomedical workforce. Measurements and Main Results: Several key issues experienced by young, underrepresented biomedical scientists were identified, and solutions were proposed to improve on training and career development for diverse students, from the high school to postdoctoral trainee level, and address limitations of currently available diversity programs. Although some of the challenges mentioned, such as cost of living, limited parental leave, and insecure extramural funding, are also likely faced by

  1. Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group.

    PubMed

    Fabsitz, Richard R; McGuire, Amy; Sharp, Richard R; Puggal, Mona; Beskow, Laura M; Biesecker, Leslie G; Bookman, Ebony; Burke, Wylie; Burchard, Esteban Gonzalez; Church, George; Clayton, Ellen Wright; Eckfeldt, John H; Fernandez, Conrad V; Fisher, Rebecca; Fullerton, Stephanie M; Gabriel, Stacey; Gachupin, Francine; James, Cynthia; Jarvik, Gail P; Kittles, Rick; Leib, Jennifer R; O'Donnell, Christopher; O'Rourke, P Pearl; Rodriguez, Laura Lyman; Schully, Sheri D; Shuldiner, Alan R; Sze, Rebecca K F; Thakuria, Joseph V; Wolf, Susan M; Burke, Gregory L

    2010-12-01

    In January 2009, the National Heart, Lung, and Blood Institute convened a 28-member multidisciplinary Working Group to update the recommendations of a 2004 National Heart, Lung, and Blood Institute Working Group focused on Guidelines to the Return of Genetic Research Results. Changes in the genetic and societal landscape over the intervening 5 years raise multiple questions and challenges. The group noted the complex issues arising from the fact that technological and bioinformatic progress has made it possible to obtain considerable information on individuals that would not have been possible a decade ago. Although unable to reach consensus on a number of issues, the working group produced 5 recommendations. The working group offers 2 recommendations addressing the criteria necessary to determine when genetic results should and may be returned to study participants, respectively. In addition, it suggests that a time limit be established to limit the duration of obligation of investigators to return genetic research results. The group recommends the creation of a central body, or bodies, to provide guidance on when genetic research results are associated with sufficient risk and have established clinical utility to justify their return to study participants. The final recommendation urges investigators to engage the broader community when dealing with identifiable communities to advise them on the return of aggregate and individual research results. Creation of an entity charged to provide guidance to institutional review boards, investigators, research institutions, and research sponsors would provide rigorous review of available data, promote standardization of study policies regarding return of genetic research results, and enable investigators and study participants to clarify and share expectations for the handling of this increasingly valuable information with appropriate respect for the rights and needs of participants.

  2. Predicting Productivity Returns on Investment: Thirty Years of Peer Review, Grant Funding, and Publication of Highly Cited Papers at the National Heart, Lung, and Blood Institute.

    PubMed

    Lauer, Michael S; Danthi, Narasimhan S; Kaltman, Jonathan; Wu, Colin

    2015-07-17

    There are conflicting data about the ability of peer review percentile rankings to predict grant productivity, as measured through publications and citations. To understand the nature of these apparent conflicting findings, we analyzed bibliometric outcomes of 6873 de novo cardiovascular R01 grants funded by the National Heart, Lung, and Blood Institute (NHLBI) between 1980 and 2011. Our outcomes focus on top-10% articles, meaning articles that were cited more often than 90% of other articles on the same topic, of the same type (eg, article, editorial), and published in the same year. The 6873 grants yielded 62 468 articles, of which 13 507 (or 22%) were top-10% articles. There was a modest association between better grant percentile ranking and number of top-10% articles. However, discrimination was poor (area under receiver operating characteristic curve [ROC], 0.52; 95% confidence interval, 0.51-0.53). Furthermore, better percentile ranking was also associated with higher annual and total inflation-adjusted grant budgets. There was no association between grant percentile ranking and grant outcome as assessed by number of top-10% articles per $million spent. Hence, the seemingly conflicting findings on peer review percentile ranking of grants and subsequent productivity largely reflect differing questions and outcomes. Taken together, these findings raise questions about how best National Institutes of Health (NIH) should use peer review assessments to make complex funding decisions.

  3. Prenatal and Perinatal Determinants of Lung Health and Disease in Early Life: A National Heart, Lung, and Blood Institute Workshop Report.

    PubMed

    Manuck, Tracy A; Levy, Philip T; Gyamfi-Bannerman, Cynthia; Jobe, Alan H; Blaisdell, Carol J

    2016-05-02

    Human lung growth and development begins with preconception exposures and continues through conception and childhood into early adulthood. Numerous environmental exposures (both positive and negative) can affect lung health and disease throughout life. Infant lung health correlates with adult lung function, but significant knowledge gaps exist regarding the influence of preconception, perinatal, and postnatal exposures on general lung health throughout life. On October 1 and 2, 2015, the National Heart, Lung, and Blood Institute convened a group of extramural investigators to develop their recommendations for the direction(s) for future research in prenatal and perinatal determinants of lung health and disease in early life and to identify opportunities for scientific advancement. They identified that future investigations will need not only to examine abnormal lung development, but also to use developing technology and resources to better define normal and/or enhanced lung health. Birth cohort studies offer key opportunities to capture the important influence of preconception and obstetric risk factors on lung health, development, and disease. These studies should include well-characterized obstetrical data and comprehensive plans for prospective follow-up. The importance of continued basic science, translational, and animal studies for providing mechanisms to explain causality using new methods cannot be overemphasized. Multidisciplinary approaches involving obstetricians, neonatologists, pediatric and adult pulmonologists, and basic scientists should be encouraged to design and conduct comprehensive and impactful research on the early stages of normal and abnormal human lung growth that influence adult outcome.

  4. Successful Semi-Ambulatory Veno-Arterial Extracorporeal Membrane Oxygenation Bridge to Heart-Lung Transplantation in a Very Small Child.

    PubMed

    Wong, J Y W; Buchholz, H; Ryerson, L; Conradi, A; Adatia, I; Dyck, J; Rebeyka, I; Lien, D; Mullen, J

    2015-08-01

    Lung transplantation (LTx) may be denied for children on extracorporeal membrane oxygenation (ECMO) due to high risk of cerebral hemorrhage. Rarely has successful LTx been reported in children over 10 years of age receiving awake or ambulatory veno-venous ECMO. LTx following support with ambulatory veno-arterial ECMO (VA ECMO) in children has never been reported to our knowledge. We present the case of a 4-year-old, 12-kg child with heritable pulmonary artery hypertension and refractory right ventricular failure. She was successfully bridged to heart-lung transplantation (HLTx) using ambulatory VA ECMO. Initial resuscitation with standard VA ECMO was converted to an ambulatory circuit using Berlin heart cannulae. She was extubated and ambulating around her bed while on VA ECMO for 40 days. She received an HLTx from an oversized marginal lung donor. Despite a cardiac arrest and Grade 3 primary graft dysfunction, she made a full recovery without neurological deficits. She achieved 104% force expiratory volume in 1 s 33 months post-HLTx. Ambulatory VA ECMO may be a useful strategy to bridge very young children to LTx or HLTx. Patient tailored ECMO cannulation, minimization of hemorrhage, and thrombosis risks while on ECMO contributed to a successful HLTx in our patient.

  5. The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop.

    PubMed

    Blajchman, Morris A; Carson, Jeffrey L; Eikelboom, John W; Heddle, Nancy M; Lacroix, Jacques; Lauer, Michael S; Platt, Richard; Tilley, Barbara; Triulzi, Darrell; Vickers, Andrew J; Yusuf, Salim; Glynn, Simone; Mondoro, Traci Heath; Wagner, Elizabeth

    2012-06-01

    Comparative effectiveness research (CER) is the study of existing treatments or ways to deliver health care to determine what intervention works best under specific circumstances. CER evaluates evidence from existing studies or generates new evidence, in different populations and under specific conditions in which the treatments are actually used. CER does not embrace one research design over another but compares treatments and variations in practice using methods that are most likely to yield widely generalizable results that are directly relevant to clinical practice. Treatments used in transfusion medicine (TM) are among the most widely used in clinical practice, but are among the least well studied. High-quality evidence is lacking for most transfusion practices, with research efforts hampered by regulatory restrictions and ethical barriers. To begin addressing these issues, the National Heart, Lung, and Blood Institute convened a workshop in June 2011 to address the potential role of CER in the generation of high-quality evidence for TM decision making. Workshop goals were to: 1) evaluate the current landscape of clinical research, 2) review the potential application of CER methods to clinical research, 3) assess potential barriers to the use of CER methodology, 4) determine whether pilot or vanguard studies can be used to facilitate planning of future CER research, and 5) consider the need for and delivery of training in CER methods for researchers.

  6. Report of a National Heart, Lung, And Blood Institute Workshop: heterogeneity in cardiometabolic risk in Asian Americans In the U.S. Opportunities for research.

    PubMed

    Narayan, K M Venkat; Aviles-Santa, Larissa; Oza-Frank, Reena; Pandey, Mona; Curb, J David; McNeely, Marguerite; Araneta, Maria Rosario G; Palaniappan, Latha; Rajpathak, Swapnil; Barrett-Connor, Elizabeth

    2010-03-09

    The Asian and Pacific Islander population (Asian Americans) in the U.S. has increased dramatically in the last few decades. Yet, data on cardiovascular disease (CVD) in this population are scarce. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health conducted an Expert Workshop to: 1) assess the importance of studying CVD in Asian Americans in the U.S.; and 2) consider strategic options for further investigations of CVD in this population. There is considerable geographical, ethnic, cultural, and genetic diversity within this population. Limited data also suggest striking differences in the risk of CVD, obesity, type 2 diabetes mellitus, and other CVD risk factors across the Asian-American population. The Asian-American population is a new diverse pool with less contemporary genetic and cultural admixture relative to groups that have lived in the U.S. for generations, plus it is diverse in lifestyle including culture, diet, and family structure. This diversity provides a window of opportunity for research on genes and gene-environment interactions and also to investigate how acculturation/assimilation to U.S. lifestyles affects health and CVD risk among relatively homogenous groups of recent immigrants. Given the heterogeneity in body weight, body size, and CVD risk, the Asian-American population in the U.S. offers a unique model to study the interaction and relationships between visceral adiposity and adipose tissue distribution and beta cell function, insulin resistance, and atherosclerosis.

  7. Lack of bronchial hyperresponsiveness to methacholine and to isocapnic dry air hyperventilation in heart/lung and double-lung transplant recipients with normal lung histology. The Paris-Sud Lung Transplant Group.

    PubMed

    Herve, P; Picard, N; Le Roy Ladurie, M; Silbert, D; Cerrina, J; Le Roy Ladurie, F; Chapelier, A; Dartevelle, P; Simonneau, G; Parquin, F

    1992-06-01

    To investigate whether survivors of heart/lung and double-lung transplantations have normal or increased nonspecific bronchial responsiveness, nine heart/lung and four double-lung transplant recipients with normal lung histology underwent methacholine challenge and voluntary isocapnic dry air hyperventilation (VIH) in a randomized order at a mean time of 14.8 +/- 12.1 months after surgery. Transplant recipients were compared with 10 normal subjects and 11 patients with mild asthma. Asthmatic patients had a mean provocative concentration of methacholine inducing a 20% fall (PC20) in FEV1 of 3.4 +/- 3.6 mg/ml (SD). Seventy seven percent of the transplant recipients and 70% of the normal subjects had PC20 superior to 32 mg/ml. The percentage fall from baseline FEV1 after VIH was 12.6 +/- 10.4% in asthmatic patients as compared with 1.9 +/- 2.9% in transplant recipients (p = 0.002) and 0.45 +/- 1.2% in normal subjects (p = 0.001). The decrease in FEV1 after VIH was similar in transplant recipients and normal subjects (p = 0.14). These results show that heart/lung or double-lung transplant recipients with normal lung histology have a normal response to nonspecific bronchial stimulation.

  8. Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study

    PubMed Central

    Robbins, Jeremy M.; Petrone, Andrew B.; Carr, J. Jeffrey; Pankow, James S.; Hunt, Steven C.; Heiss, Gerardo; Arnett, Donna K.; Ellison, R. Curtis; Gaziano, J. Michael; Djoussé, Luc

    2015-01-01

    Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease (CVD) by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease (CHD). We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods and Results In a cross-sectional design, we studied 1731 predominantly Caucasian men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent CHD. Diet was assessed by a semi-quantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Mean age was 56.8 years and 41% were male. The median number of ideal CVH metrics was 3, and no participants met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29–0.45), 0.35 (0.26–0.44), and 0.27 (0.20–0.36) among subjects with 0–1, 2, 3, and 4+ ideal CVH metrics, respectively (p for trend: 0.0001), adjusting for sex, age, field center, alcohol, income, education, and calorie consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women. PMID:25728727

  9. Ethnic differences in the presentation, treatment strategy, and outcomes of percutaneous coronary intervention (a report from the National Heart, Lung, and Blood Institute Dynamic Registry).

    PubMed

    Slater, James; Selzer, Faith; Dorbala, Sharmila; Tormey, Deborah; Vlachos, Helen A; Wilensky, Robert L; Jacobs, Alice K; Laskey, Warren K; Douglas, John S; Williams, David O; Kelsey, Sheryl F

    2003-10-01

    Information about the impact of race/ethnicity on adverse outcomes after percutaneous coronary intervention (PCI) in the modern era is limited. Using consecutive patients from the National Heart, Lung, and Blood Institute Dynamic Registry, this study investigated differences in clinical presentation, treatment strategy, and acute and long-term outcomes in 3,669 white, 446 black, 301 Hispanic, and 201 Asian patients who underwent PCI. All comparisons were made to whites. Blacks were more likely than whites to be younger, women, and to present with a higher prevalence of cardiovascular risk factors (hypertension, diabetes, and smoking). Hispanics tended to be younger, hypertensive, diabetic, and to be undergoing their first cardiovascular procedure. Asians were, on average, younger, men, and presented more often with hypertension and diabetes than whites. Although the rate of stent implantation was significantly lower in blacks compared with whites (63% vs 74%, p <0.001), angiographic and procedural success rates were high (> or =95%) and did not differ by race/ethnicity. In-hospital mortality (0.2% vs 1.7%, p <0.05) and death/myocardial infarction (MI)/coronary artery bypass grafting (CABG) (3.1% vs 5.5%, p <0.05) were lower in blacks. All other in-hospital complications were similar to whites. At 1 year, there were no statistical differences in cumulative adverse event rates by ethnicity; however by 2 years there was a modestly higher mortality rate (adjusted RR 1.87; 95% confidence interval 1.15 to 3.04) and adverse event rate (death/MI, death/MI/CABG) among black patients. Thus, although differences in patient demographics, clinical presentation, angiographic characteristics and treatment strategies did not impact the incidence of acute and 1-year adverse outcomes of non-whites, there appears to be a significant reduction in event-free survival among blacks by 2 years.

  10. The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): A research program striving to improve blood donor and transfusion recipient outcomes

    PubMed Central

    Kleinman, Steven; Busch, Michael P; Murphy, Edward L; Shan, Hua; Ness, Paul; Glynn, Simone A.

    2014-01-01

    Background The Recipient Epidemiology and Donor Evaluation Study -III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute. Study design The domestic component involves 4 blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa which involve US and in-country investigators. Results REDS-III is using two major methods to address key research priorities in blood banking/transfusion medicine. First, there will be numerous analyses of large “core” databases; the international programs have each constructed a donor/donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Secondly, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that are either in progress or scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization; transfusion outcomes; non-infectious transfusion risks; HIV-related safety issues (particularly in the international programs); emerging infectious agents; blood component quality; donor health and safety; and other donor issues. Conclusions It is intended that REDS-III serve as an impetus for more widespread recipient and linked donor-recipient research in the US as well as to help assure a safe and available blood supply in the US and in international locations. PMID:24188564

  11. A Perspective on Promoting Diversity in the Biomedical Research Workforce: The National Heart, Lung, and Blood Institute’s PRIDE Program

    PubMed Central

    Boyington, Josephine E.A.; Maihle, Nita J.; Rice, Treva K.; Gonzalez, Juan E.; Hess, Caryl A.; Makala, Levi H.; Jeffe, Donna B.; Ogedegbe, Gbenga; Rao, Dabeeru C.; Dávila-Román, Victor G.; Pace, Betty S.; Jean-Louis, Girardin; Boutjdir, Mohamed

    2016-01-01

    Aspiring junior investigators from groups underrepresented in the biomedical sciences face various challenges as they pursue research independence. However, the biomedical research enterprise needs their participation to effectively address critical research issues such as health disparities and health inequities. In this article, we share a research education and mentoring initiative that seeks to address this challenge: Programs to Increase Diversity among Individuals Engaged in Health Related Research (PRIDE), funded by the National Heart, Lung, and Blood Institute (NHLBI). This longitudinal research-education and mentoring program occurs through summer institute programs located at US-based academic institutions. Recruited participants are exposed to didactic and lab-based research-skill enhancement experiences, with year-round mentoring over the course of two years. Mentor-mentee matching is based on shared research interests to promote congruence and to enhance skill acquisition. Program descriptions and sample narratives of participants’ perceptions of PRIDE’s impact on their career progress are showcased. Additionally, we highlight the overall program design and structure of four of seven funded summer institutes that focus on cardiovascular disease, related conditions, and health disparities. Mentees’ testimonials about the value of the PRIDE mentoring approach in facilitating career development are also noted. Meeting the clinical and research needs of an increasingly diverse US population is an issue of national concern. The PRIDE initiative, which focuses on increasing research preparedness and professional development of groups underrepresented in the biomedical research workforce, with an emphasis on mentoring as the critical approach, provides a robust model that is impacting the careers of future investigators. PMID:27440978

  12. Clinical trial opportunities in Transfusion Medicine: proceedings of a National Heart, Lung, and Blood Institute State-of-the-Science Symposium.

    PubMed

    Blajchman, Morris A; Glynn, Simone A; Josephson, Cassandra D; Kleinman, Steve H

    2010-10-01

    The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely because of the lack of robust clinical trial data, in many instances, which are critical for providing practitioners with evidence-based guidelines for appropriate blood product utilization. Recognizing this gap, the National Heart, Lung, and Blood Institute recently established a State-of-the-Science Symposium to help define areas of clinical trial research that would enhance the opportunity for developing appropriate practice guidelines for both Transfusion Medicine and Hemostasis/Thrombosis. Such a Symposium was held in September 2009 to identify important clinical trial research issues in these 2 subject areas of endeavor. The aims of this Symposium were to specifically identify phase 2 and 3 clinical trials that, if conducted over the next 5 to 10 years, could impact the treatment of patients with hemostatic and other disorders as well as to optimize the use of blood products in patients who need such interventions. This article reports on the deliberations that were held relating to the various clinical trial concepts developed by 7 Transfusion Medicine subcommittees. This Symposium generated a rich assortment of clinical trial proposals that will undergo further refinement before final implementation into pilot or full randomized clinical trials. The various proposals identified many opportunities for clinical trial research and most importantly underscored the ongoing need for well-developed evidence-based clinical trial research in the field of Transfusion Medicine.

  13. Machine Shop Grinding Machines.

    ERIC Educational Resources Information Center

    Dunn, James

    This curriculum manual is one in a series of machine shop curriculum manuals intended for use in full-time secondary and postsecondary classes, as well as part-time adult classes. The curriculum can also be adapted to open-entry, open-exit programs. Its purpose is to equip students with basic knowledge and skills that will enable them to enter the…

  14. Heart-lung transplant - slideshow

    MedlinePlus

    ... this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy , editorial process and privacy policy . A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www. ...

  15. Database machines

    NASA Technical Reports Server (NTRS)

    Stiefel, M. L.

    1983-01-01

    The functions and performance characteristics of data base machines (DBM), including machines currently being studied in research laboratories and those currently offered on a commerical basis are discussed. The cost/benefit considerations that must be recognized in selecting a DBM are discussed, as well as the future outlook for such machines.

  16. Electric machine

    DOEpatents

    El-Refaie, Ayman Mohamed Fawzi [Niskayuna, NY; Reddy, Patel Bhageerath [Madison, WI

    2012-07-17

    An interior permanent magnet electric machine is disclosed. The interior permanent magnet electric machine comprises a rotor comprising a plurality of radially placed magnets each having a proximal end and a distal end, wherein each magnet comprises a plurality of magnetic segments and at least one magnetic segment towards the distal end comprises a high resistivity magnetic material.

  17. Reviving the vascular surgeon-scientist: an interim assessment of the jointly sponsored Lifeline Foundation/National Heart, Lung, and Blood Institute William J. von Liebig Mentored Clinical Scientist Development (K08) Program.

    PubMed

    Thompson, Robert W; Schucker, Beth; Kent, K Craig; Clowes, Alexander W; Kraiss, Larry W; Mannick, John A; Yao, James S T

    2007-06-01

    The Lifeline Foundation/National Heart, Lung, and Blood Institute William J. von Liebig Mentored Clinical Scientist Development (K08) Award program was established as a unique partnership to support vascular surgeon-scientists. Between 1999 and 2005, 39 applications were submitted, and the overall funding rate was 49% (14 von Liebig K08s and 5 additional NHLBI K08s). Vascular surgeon K08 recipients (median age, 38 years) had held faculty appointments for 2.5 +/- 0.4 years, with 2.6 +/- 0.2 years of previous research experience and 28.4 +/- 6.2 publications. These individuals subsequently authored 5.1 +/- 0.8 peer-reviewed publications per recipient per year, of which 35% were research and 65% were clinical. Six of seven holding the K08 over 3 years had received academic promotion, and all five completing the 5-year award had achieved independent investigator status with National Institutes of Health support. The von Liebig K08 program has therefore been an effective vehicle to stimulate research career development in the field of vascular surgery.

  18. Workout Machine

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Orbotron is a tri-axle exercise machine patterned after a NASA training simulator for astronaut orientation in the microgravity of space. It has three orbiting rings corresponding to roll, pitch and yaw. The user is in the middle of the inner ring with the stomach remaining in the center of all axes, eliminating dizziness. Human power starts the rings spinning, unlike the NASA air-powered system. Marketed by Fantasy Factory (formerly Orbotron, Inc.), the machine can improve aerobic capacity, strength and endurance in five to seven minute workouts.

  19. Wacky Machines

    ERIC Educational Resources Information Center

    Fendrich, Jean

    2002-01-01

    Collectors everywhere know that local antique shops and flea markets are treasure troves just waiting to be plundered. Science teachers might take a hint from these hobbyists, for the next community yard sale might be a repository of old, quirky items that are just the things to get students thinking about simple machines. By introducing some…

  20. Machine Learning

    NASA Astrophysics Data System (ADS)

    Hoffmann, Achim; Mahidadia, Ashesh

    The purpose of this chapter is to present fundamental ideas and techniques of machine learning suitable for the field of this book, i.e., for automated scientific discovery. The chapter focuses on those symbolic machine learning methods, which produce results that are suitable to be interpreted and understood by humans. This is particularly important in the context of automated scientific discovery as the scientific theories to be produced by machines are usually meant to be interpreted by humans. This chapter contains some of the most influential ideas and concepts in machine learning research to give the reader a basic insight into the field. After the introduction in Sect. 1, general ideas of how learning problems can be framed are given in Sect. 2. The section provides useful perspectives to better understand what learning algorithms actually do. Section 3 presents the Version space model which is an early learning algorithm as well as a conceptual framework, that provides important insight into the general mechanisms behind most learning algorithms. In section 4, a family of learning algorithms, the AQ family for learning classification rules is presented. The AQ family belongs to the early approaches in machine learning. The next, Sect. 5 presents the basic principles of decision tree learners. Decision tree learners belong to the most influential class of inductive learning algorithms today. Finally, a more recent group of learning systems are presented in Sect. 6, which learn relational concepts within the framework of logic programming. This is a particularly interesting group of learning systems since the framework allows also to incorporate background knowledge which may assist in generalisation. Section 7 discusses Association Rules - a technique that comes from the related field of Data mining. Section 8 presents the basic idea of the Naive Bayesian Classifier. While this is a very popular learning technique, the learning result is not well suited for

  1. Charging machine

    DOEpatents

    Medlin, John B.

    1976-05-25

    A charging machine for loading fuel slugs into the process tubes of a nuclear reactor includes a tubular housing connected to the process tube, a charging trough connected to the other end of the tubular housing, a device for loading the charging trough with a group of fuel slugs, means for equalizing the coolant pressure in the charging trough with the pressure in the process tubes, means for pushing the group of fuel slugs into the process tube and a latch and a seal engaging the last object in the group of fuel slugs to prevent the fuel slugs from being ejected from the process tube when the pusher is removed and to prevent pressure liquid from entering the charging machine.

  2. Induction machine

    DOEpatents

    Owen, Whitney H.

    1980-01-01

    A polyphase rotary induction machine for use as a motor or generator utilizing a single rotor assembly having two series connected sets of rotor windings, a first stator winding disposed around the first rotor winding and means for controlling the current induced in one set of the rotor windings compared to the current induced in the other set of the rotor windings. The rotor windings may be wound rotor windings or squirrel cage windings.

  3. Machine vision

    SciTech Connect

    Horn, D.

    1989-06-01

    To keep up with the speeds of modern production lines, most machine vision applications require very powerful computers (often parallel-processing machines), which process millions of points of data in real time. The human brain performs approximately 100 billion logical floating-point operations each second. That is 400 times the speed of a Cray-1 supercomputer. The right software must be developed for parallel-processing computers. The NSF has awarded Rensselaer Polytechnic Institute (Troy, N.Y.) a $2 million grant for parallel- and image-processing software research. Over the last 15 years, Rensselaer has been conducting image-processing research, including work with high-definition TV (HDTV) and image coding and understanding. A similar NSF grant has been awarded to Michigan State University (East Lansing, Mich.) Neural networks are supposed to emulate human learning patterns. These networks and their hardware implementations (neurocomputers) show a great deal of promise for machine vision systems because they allow the systems to understand the use sensory data input more effectively. Neurocomputers excel at pattern-recognition tasks when input data are fuzzy or the vision algorithm is not optimal and is difficult to ascertain.

  4. Rat heparins. A study of the relative sizes and antithrombin-binding characteristics of heparin proteoglycans, chains and depolymerization products from rat adipose tissue, heart, lungs, peritoneal cavity and skin.

    PubMed Central

    Horner, A A

    1986-01-01

    35S-labelled heparins were recovered from adipose tissue, hearts, lungs, peritoneal cavities and skins of rats given H2(35)SO4. Their purification involved incubation with Pronase, precipitation with cetylpyridinium chloride in 1.0 M-NaCl, gradient elution from DEAE-Sephacel and incubation with chondroitinase ABC. Each product was divided into proteoglycan and "depolymerization products' fractions by gel filtration on Bio-Gel A-15m. Heparin chains were released from a portion of each proteoglycan fraction by beta-elimination with NaOH. Proteoglycans, chains and depolymerization products were separated by gradient elution from a column of antithrombin-agarose into fractions with no affinity, low affinity and high affinity for antithrombin. The relative sizes of the products were determined by gel filtration on columns of Bio-Gel A-50m, A-15m, A-1.5m and A-0.5m. Skin was the major source of heparin and contained the largest proteoglycans and the lowest proportion of depolymerization products. Lungs contained the smallest proteoglycans, the smallest depolymerization products and the highest proportion of depolymerization products. The highest proportions of proteoglycans, chains and depolymerization products with high affinity for antithrombin were found in adipose tissue. The lowest proportions of each of these fractions were found in the peritoneal cavity. The data suggest that there was relatively little biosynthesis of sites with high affinity for antithrombin in peritoneal-cavity mast cells and that heparin catabolism was most active in lungs. Each source of heparin was unique with respect to both biosynthesis and subsequent breakdown of its proteoglycans. PMID:3827837

  5. TEMPO machine

    SciTech Connect

    Rohwein, G.J.; Lancaster, K.T.; Lawson, R.N.

    1986-06-01

    TEMPO is a transformer powered megavolt pulse generator with an output pulse of 100 ns duration. The machine was designed for burst mode operation at pulse repetition rates up to 10 Hz with minimum pulse-to-pulse voltage variations. To meet the requirement for pulse duration a nd a 20-..omega.. output impedance within reasonable size constraints, the pulse forming transmission line was designed as two parallel water-insulated, strip-type Blumleins. Stray capacitance and electric fields along the edges of the line elements were controlled by lining the tank with plastic sheet.

  6. Parallel machines: Parallel machine languages

    SciTech Connect

    Iannucci, R.A. )

    1990-01-01

    This book presents a framework for understanding the tradeoffs between the conventional view and the dataflow view with the objective of discovering the critical hardware structures which must be present in any scalable, general-purpose parallel computer to effectively tolerate latency and synchronization costs. The author presents an approach to scalable general purpose parallel computation. Linguistic Concerns, Compiling Issues, Intermediate Language Issues, and hardware/technological constraints are presented as a combined approach to architectural Develoement. This book presents the notion of a parallel machine language.

  7. The vascular surgeon-scientist: a 15-year report of the Society for Vascular Surgery Foundation/National Heart, Lung, and Blood Institute-mentored Career Development Award Program.

    PubMed

    Kibbe, Melina R; Dardik, Alan; Velazquez, Omaida C; Conte, Michael S

    2015-04-01

    The Society for Vascular Surgery (SVS) Foundation partnered with the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) in 1999 to initiate a competitive career development program that provides a financial supplement to surgeon-scientists receiving NIH K08 or K23 career development awards. Because the program has been in existence for 15 years, a review of the program's success has been performed. Between 1999 and 2013, 41 faculty members applied to the SVS Foundation program, and 29 from 21 different institutions were selected as awardees, resulting in a 71% success rate. Three women (10%) were among the 29 awardees. Nine awardees (31%) were supported by prior NIH F32 or T32 training grants. Awardees received their K award at an average of 3.5 years from the start of their faculty position, at the average age of 39.8 years. Thirteen awardees (45%) have subsequently received NIH R01 awards and five (17%) have received Veterans Affairs Merit Awards. Awardees received their first R01 at an average of 5.8 years after the start of their K award at the average age of 45.2 years. The SVS Foundation committed $9,350,000 to the Career Development Award Program. Awardees subsequently secured $45,108,174 in NIH and Veterans Affairs funds, resulting in a 4.8-fold financial return on investment for the SVS Foundation program. Overall, 23 awardees (79%) were promoted from assistant to associate professor in an average of 5.9 years, and 10 (34%) were promoted from associate professor to professor in an average of 5.2 years. Six awardees (21%) hold endowed professorships and four (14%) have secured tenure. Many of the awardees hold positions of leadership, including 12 (41%) as division chief and two (7%) as vice chair within a department of surgery. Eight (28%) awardees have served as president of a regional or national society. Lastly, 47 postdoctoral trainees have been mentored by recipients of the SVS Foundation Career Development

  8. National Heart, Lung, and Blood Institute

    MedlinePlus

    ... risk factors linked to brain amyloid, development of Alzheimer’s disease April 06, 2017 News NHLBI Stem Cell Consortium Provides New Insights into Genetics of Heart Disease, Other Conditions Spotlight on Research ...

  9. Machine musicianship

    NASA Astrophysics Data System (ADS)

    Rowe, Robert

    2002-05-01

    The training of musicians begins by teaching basic musical concepts, a collection of knowledge commonly known as musicianship. Computer programs designed to implement musical skills (e.g., to make sense of what they hear, perform music expressively, or compose convincing pieces) can similarly benefit from access to a fundamental level of musicianship. Recent research in music cognition, artificial intelligence, and music theory has produced a repertoire of techniques that can make the behavior of computer programs more musical. Many of these were presented in a recently published book/CD-ROM entitled Machine Musicianship. For use in interactive music systems, we are interested in those which are fast enough to run in real time and that need only make reference to the material as it appears in sequence. This talk will review several applications that are able to identify the tonal center of musical material during performance. Beyond this specific task, the design of real-time algorithmic listening through the concurrent operation of several connected analyzers is examined. The presentation includes discussion of a library of C++ objects that can be combined to perform interactive listening and a demonstration of their capability.

  10. Flotation machine

    SciTech Connect

    Zlobin, M.N.; Permyakov, G.P.; Nemarov, A.A.; Metsik, V.M.; Medetsky, J.V.; Taraban, N.T.

    1993-08-10

    A flotation machine is described for beneficiating minerals comprising: a vertical cylindrical chamber for circulating a flotation pulp; a downwardly tapered bottom connected to said vertical cylindrical chamber; feed pipe means for feeding the flotation pulp carrying mineral particles of fine fraction, particles of the useful ingredient of the fine fraction being capable of floating up from the volume of said aerated pulp; discharge pipe means connected to the tapered bottom near its lowest point for discharging gangue; an annular trough for collecting froth concentrate at the top of said chamber; a group of frustoconical shells each having bases of different diameters and a tapered surface secured axially in said chamber and spaced equidistantly from one another height wise of said chamber; aerator means for aerating the flotation pulp secured to the walls of said chamber and communicating therewith to provide aerated water into said chamber; means for feeding mineral particles of coarse fraction, particles of the useful ingredient of the coarse fraction being capable of floating in the froth layer of the flotation pulp, in the form of a hydrocyclone having a cylindrical casing positioned axially over said chamber and a downwardly tapering outlet directed downwardly to feed the coarse particles to said chamber; feed pipe means for feeding the flotation pulp carrying mineral particles of coarse fraction positioned tangentially at said cylindrical casing of the hydrocyclone; and evacuation means for evacuating the liquid phase of the flotation pulp positioned tangentially at said casing of the hydrocyclone over said feed pipe means and connected to said feed pipe means for feeding the flotation pulp carrying mineral particles of the fine fraction.

  11. Stirling machine operating experience

    NASA Technical Reports Server (NTRS)

    Ross, Brad; Dudenhoefer, James E.

    1991-01-01

    Numerous Stirling machines have been built and operated, but the operating experience of these machines is not well known. It is important to examine this operating experience in detail, because it largely substantiates the claim that Stirling machines are capable of reliable and lengthy lives. The amount of data that exists is impressive, considering that many of the machines that have been built are developmental machines intended to show proof of concept, and were not expected to operate for any lengthy period of time. Some Stirling machines (typically free-piston machines) achieve long life through non-contact bearings, while other Stirling machines (typically kinematic) have achieved long operating lives through regular seal and bearing replacements. In addition to engine and system testing, life testing of critical components is also considered.

  12. Women, Men, and Machines.

    ERIC Educational Resources Information Center

    Form, William; McMillen, David Byron

    1983-01-01

    Data from the first national study of technological change show that proportionately more women than men operate machines, are more exposed to machines that have alienating effects, and suffer more from the negative effects of technological change. (Author/SSH)

  13. The Iowa wave machines

    NASA Astrophysics Data System (ADS)

    Daffron, John D.; Greenslade, Thomas B.; Stille, Dale

    2010-03-01

    Wave machines are a staple of demonstration lectures, and a good pair of wave machines can make the idea of transverse and longitudinal waves clearly evident to students. The demonstration apparatus collection of the University of Iowa contains examples of transverse and longitudinal wave machines that will be of interest to readers of The Physics Teacher. These machines probably date from about 1925 and may have been locally produced. You too can build them.

  14. Cable-Twisting Machine

    NASA Technical Reports Server (NTRS)

    Kurnett, S.

    1982-01-01

    New cable-twisting machine is smaller and faster than many production units. Is useful mainly in production of short-run special cables. Already-twisted cable can be fed along axis of machine. Faster operation than typical industrial cable-twisting machines possible by using smaller spools of wire.

  15. Apprentice Machine Theory Outline.

    ERIC Educational Resources Information Center

    Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

    This volume contains outlines for 16 courses in machine theory that are designed for machine tool apprentices. Addressed in the individual course outlines are the following topics: basic concepts; lathes; milling machines; drills, saws, and shapers; heat treatment and metallurgy; grinders; quality control; hydraulics and pneumatics;…

  16. Clamping in Boltzmann machines.

    PubMed

    Livesey, M

    1991-01-01

    A certain assumption that appears in the proof of correctness of the standard Boltzmann machine learning procedure is investigated. The assumption, called the clamping assumption, concerns the behavior of a Boltzmann machine when some of its units are clamped to a fixed state. It is argued that the clamping assumption is essentially an assertion of the time reversibility of a certain Markov chain underlying the behavior of the Boltzmann machine. As such, the clamping assumption is generally false, though it is certainly true of the Boltzmann machines themselves. The author also considers how the concept of the Boltzmann machine may be generalized while retaining the validity of the clamping assumption.

  17. Perspex machine: VII. The universal perspex machine

    NASA Astrophysics Data System (ADS)

    Anderson, James A. D. W.

    2006-01-01

    The perspex machine arose from the unification of projective geometry with the Turing machine. It uses a total arithmetic, called transreal arithmetic, that contains real arithmetic and allows division by zero. Transreal arithmetic is redefined here. The new arithmetic has both a positive and a negative infinity which lie at the extremes of the number line, and a number nullity that lies off the number line. We prove that nullity, 0/0, is a number. Hence a number may have one of four signs: negative, zero, positive, or nullity. It is, therefore, impossible to encode the sign of a number in one bit, as floating-point arithmetic attempts to do, resulting in the difficulty of having both positive and negative zeros and NaNs. Transrational arithmetic is consistent with Cantor arithmetic. In an extension to real arithmetic, the product of zero, an infinity, or nullity with its reciprocal is nullity, not unity. This avoids the usual contradictions that follow from allowing division by zero. Transreal arithmetic has a fixed algebraic structure and does not admit options as IEEE, floating-point arithmetic does. Most significantly, nullity has a simple semantics that is related to zero. Zero means "no value" and nullity means "no information." We argue that nullity is as useful to a manufactured computer as zero is to a human computer. The perspex machine is intended to offer one solution to the mind-body problem by showing how the computable aspects of mind and, perhaps, the whole of mind relates to the geometrical aspects of body and, perhaps, the whole of body. We review some of Turing's writings and show that he held the view that his machine has spatial properties. In particular, that it has the property of being a 7D lattice of compact spaces. Thus, we read Turing as believing that his machine relates computation to geometrical bodies. We simplify the perspex machine by substituting an augmented Euclidean geometry for projective geometry. This leads to a general

  18. Machine tool locator

    DOEpatents

    Hanlon, John A.; Gill, Timothy J.

    2001-01-01

    Machine tools can be accurately measured and positioned on manufacturing machines within very small tolerances by use of an autocollimator on a 3-axis mount on a manufacturing machine and positioned so as to focus on a reference tooling ball or a machine tool, a digital camera connected to the viewing end of the autocollimator, and a marker and measure generator for receiving digital images from the camera, then displaying or measuring distances between the projection reticle and the reference reticle on the monitoring screen, and relating the distances to the actual position of the autocollimator relative to the reference tooling ball. The images and measurements are used to set the position of the machine tool and to measure the size and shape of the machine tool tip, and examine cutting edge wear. patent

  19. Agent Based Computing Machine

    DTIC Science & Technology

    2005-12-09

    coordinates as in cellular automata systems. But using biology as a model suggests that the most general systems must provide for partial, but constrained...17. SECURITY CLASSIFICATION OF 118. SECURITY CLASSIFICATION OF 19. SECURITY CLASSIFICATION OF 20. LIMITATION OF ABSTRA REPORT THIS PAGE ABSTRACT...system called an "agent based computing" machine (ABC Machine). The ABC Machine is motivated by cellular biochemistry and it is based upon a concept

  20. Perspex machine II: visualization

    NASA Astrophysics Data System (ADS)

    Anderson, James A. D. W.

    2004-12-01

    We review the perspex machine and improve it by reducing its halting conditions to one condition. We also introduce a data structure, called the "access column," that can accelerate a wide class of perspex programs. We show how the perspex can be visualised as a tetrahedron, artificial neuron, computer program, and as a geometrical transformation. We discuss the temporal properties of the perspex machine, dissolve the famous time travel paradox, and present a hypothetical time machine. Finally, we discuss some mental properties and show how the perspex machine solves the mind-body problem and, specifically, how it provides one physical explanation for the occurrence of paradigm shifts.

  1. Perspex machine II: visualization

    NASA Astrophysics Data System (ADS)

    Anderson, James A. D. W.

    2005-01-01

    We review the perspex machine and improve it by reducing its halting conditions to one condition. We also introduce a data structure, called the "access column," that can accelerate a wide class of perspex programs. We show how the perspex can be visualised as a tetrahedron, artificial neuron, computer program, and as a geometrical transformation. We discuss the temporal properties of the perspex machine, dissolve the famous time travel paradox, and present a hypothetical time machine. Finally, we discuss some mental properties and show how the perspex machine solves the mind-body problem and, specifically, how it provides one physical explanation for the occurrence of paradigm shifts.

  2. Progress in machine consciousness.

    PubMed

    Gamez, David

    2008-09-01

    This paper is a review of the work that has been carried out on machine consciousness. A clear overview of this diverse field is achieved by breaking machine consciousness down into four different areas, which are used to understand its aims, discuss its relationship with other subjects and outline the work that has been carried out so far. The criticisms that have been made against machine consciousness are also covered, along with its potential benefits, and the work that has been done on analysing systems for signs of consciousness. Some of the social and ethical issues raised by machine consciousness are examined at the end of the paper.

  3. Chaotic Boltzmann machines

    NASA Astrophysics Data System (ADS)

    Suzuki, Hideyuki; Imura, Jun-Ichi; Horio, Yoshihiko; Aihara, Kazuyuki

    2013-04-01

    The chaotic Boltzmann machine proposed in this paper is a chaotic pseudo-billiard system that works as a Boltzmann machine. Chaotic Boltzmann machines are shown numerically to have computing abilities comparable to conventional (stochastic) Boltzmann machines. Since no randomness is required, efficient hardware implementation is expected. Moreover, the ferromagnetic phase transition of the Ising model is shown to be characterised by the largest Lyapunov exponent of the proposed system. In general, a method to relate probabilistic models to nonlinear dynamics by derandomising Gibbs sampling is presented.

  4. Chaotic Boltzmann machines.

    PubMed

    Suzuki, Hideyuki; Imura, Jun-ichi; Horio, Yoshihiko; Aihara, Kazuyuki

    2013-01-01

    The chaotic Boltzmann machine proposed in this paper is a chaotic pseudo-billiard system that works as a Boltzmann machine. Chaotic Boltzmann machines are shown numerically to have computing abilities comparable to conventional (stochastic) Boltzmann machines. Since no randomness is required, efficient hardware implementation is expected. Moreover, the ferromagnetic phase transition of the Ising model is shown to be characterised by the largest Lyapunov exponent of the proposed system. In general, a method to relate probabilistic models to nonlinear dynamics by derandomising Gibbs sampling is presented.

  5. Drum cutter mining machine

    SciTech Connect

    Oberste-beulmann, K.; Schupphaus, H.

    1980-02-19

    A drum cutter mining machine includes a machine frame with a winch having a drive wheel to engage a rack or chain which extends along the path of travel by the mining machine to propel the machine along a mine face. The mining machine is made up of discrete units which include a machine body and machine housings joined to opposite sides of the machine body. The winch is either coupled through a drive train with a feed drive motor or coupled to the drive motor for cutter drums. The machine housings each support a pivot shaft coupled by an arm to a drum cutter. One of these housings includes a removable end cover and a recess adapted to receive a support housing for a spur gear system used to transmit torque from a feed drive motor to a reduction gear system which is, in turn, coupled to the drive wheel of the winch. In one embodiment, a removable end cover on the machine housing provides access to the feed drive motor. The feed drive motor is arranged so that the rotational axis of its drive output shaft extends transversely to the stow side of the machine frame. In another embodiment, the reduction gear system is arranged at one side of the pivot shaft for the cutter drum while the drive motor therefor is arranged at the other side of the pivot shaft and coupled thereto through the spur gear system. In a further embodiment, the reduction gear system is disposed between the feed motor and the pivot shaft.

  6. Diamond machine tool face lapping machine

    DOEpatents

    Yetter, H.H.

    1985-05-06

    An apparatus for shaping, sharpening and polishing diamond-tipped single-point machine tools. The isolation of a rotating grinding wheel from its driving apparatus using an air bearing and causing the tool to be shaped, polished or sharpened to be moved across the surface of the grinding wheel so that it does not remain at one radius for more than a single rotation of the grinding wheel has been found to readily result in machine tools of a quality which can only be obtained by the most tedious and costly processing procedures, and previously unattainable by simple lapping techniques.

  7. 14. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to north (90mm lens). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  8. BRITISH MOLDING MACHINE, PBQ AUTOMATIC COPE AND DRAG MOLDING MACHINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BRITISH MOLDING MACHINE, PBQ AUTOMATIC COPE AND DRAG MOLDING MACHINE MAKES BOTH MOLD HALVES INDIVIDUALLY WHICH ARE LATER ROTATED, ASSEMBLED, AND LOWERED TO POURING CONVEYORS BY ASSISTING MACHINES. - Southern Ductile Casting Company, Casting, 2217 Carolina Avenue, Bessemer, Jefferson County, AL

  9. THE TEACHING MACHINE.

    ERIC Educational Resources Information Center

    KLEIN, CHARLES; WAYNE, ELLIS

    THE ROLE OF THE TEACHING MACHINE IS COMPARED WITH THE ROLE OF THE PROGRAMED TEXTBOOK. THE TEACHING MACHINE IS USED FOR INDIVIDUAL INSTRUCTION, CONTAINS AND PRESENTS PROGRAM CONTENT IN STEPS, PROVIDES A MEANS WHEREBY THE STUDENT MAY RESPOND TO THE PROGRAM, PROVIDES THE STUDENT WITH IMMEDIATE INFORMATION OF SOME KIND CONCERNING HIS RESPONSE THAT CAN…

  10. Semantics via Machine Translation

    ERIC Educational Resources Information Center

    Culhane, P. T.

    1977-01-01

    Recent experiments in machine translation have given the semantic elements of collocation in Russian more objective criteria. Soviet linguists in search of semantic relationships have attempted to devise a semantic synthesis for construction of a basic language for machine translation. One such effort is summarized. (CHK)

  11. The Hooey Machine.

    ERIC Educational Resources Information Center

    Scarnati, James T.; Tice, Craig J.

    1992-01-01

    Describes how students can make and use Hooey Machines to learn how mechanical energy can be transferred from one object to another within a system. The Hooey Machine is made using a pencil, eight thumbtacks, one pushpin, tape, scissors, graph paper, and a plastic lid. (PR)

  12. Machining heavy plastic sections

    NASA Technical Reports Server (NTRS)

    Stalkup, O. M.

    1967-01-01

    Machining technique produces consistently satisfactory plane-parallel optical surfaces for pressure windows, made of plexiglass, required to support a photographic study of liquid rocket combustion processes. The surfaces are machined and polished to the required tolerances and show no degradation from stress relaxation over periods as long as 6 months.

  13. Technique for Machining Glass

    NASA Technical Reports Server (NTRS)

    Rice, S. H.

    1982-01-01

    Process for machining glass with conventional carbide tools requires a small quantity of a lubricant for aluminum applied to area of glass to be machined. A carbide tool is then placed against workpiece with light pressure. Tool is raised periodically to clear work of glass dust and particles. Additional lubricant is applied as it is displaced.

  14. Compound taper milling machine

    NASA Technical Reports Server (NTRS)

    Campbell, N. R.

    1969-01-01

    Simple, inexpensive milling machine tapers panels from a common apex to a uniform height at panel edge regardless of the panel perimeter configuration. The machine consists of an adjustable angled beam upon which the milling tool moves back and forth above a rotatable table upon which the workpiece is held.

  15. Stirling machine operating experience

    SciTech Connect

    Ross, B.; Dudenhoefer, J.E.

    1994-09-01

    Numerous Stirling machines have been built and operated, but the operating experience of these machines is not well known. It is important to examine this operating experience in detail, because it largely substantiates the claim that stirling machines are capable of reliable and lengthy operating lives. The amount of data that exists is impressive, considering that many of the machines that have been built are developmental machines intended to show proof of concept, and are not expected to operate for lengthy periods of time. Some Stirling machines (typically free-piston machines) achieve long life through non-contact bearings, while other Stirling machines (typically kinematic) have achieved long operating lives through regular seal and bearing replacements. In addition to engine and system testing, life testing of critical components is also considered. The record in this paper is not complete, due to the reluctance of some organizations to release operational data and because several organizations were not contacted. The authors intend to repeat this assessment in three years, hoping for even greater participation.

  16. Machine Translation Project

    NASA Technical Reports Server (NTRS)

    Bajis, Katie

    1993-01-01

    The characteristics and capabilities of existing machine translation systems were examined and procurement recommendations were developed. Four systems, SYSTRAN, GLOBALINK, PC TRANSLATOR, and STYLUS, were determined to meet the NASA requirements for a machine translation system. Initially, four language pairs were selected for implementation. These are Russian-English, French-English, German-English, and Japanese-English.

  17. Simple Machines Made Simple.

    ERIC Educational Resources Information Center

    St. Andre, Ralph E.

    Simple machines have become a lost point of study in elementary schools as teachers continue to have more material to cover. This manual provides hands-on, cooperative learning activities for grades three through eight concerning the six simple machines: wheel and axle, inclined plane, screw, pulley, wedge, and lever. Most activities can be…

  18. Simple Machine Junk Cars

    ERIC Educational Resources Information Center

    Herald, Christine

    2010-01-01

    During the month of May, the author's eighth-grade physical science students study the six simple machines through hands-on activities, reading assignments, videos, and notes. At the end of the month, they can easily identify the six types of simple machine: inclined plane, wheel and axle, pulley, screw, wedge, and lever. To conclude this unit,…

  19. Introduction to machine learning.

    PubMed

    Baştanlar, Yalin; Ozuysal, Mustafa

    2014-01-01

    The machine learning field, which can be briefly defined as enabling computers make successful predictions using past experiences, has exhibited an impressive development recently with the help of the rapid increase in the storage capacity and processing power of computers. Together with many other disciplines, machine learning methods have been widely employed in bioinformatics. The difficulties and cost of biological analyses have led to the development of sophisticated machine learning approaches for this application area. In this chapter, we first review the fundamental concepts of machine learning such as feature assessment, unsupervised versus supervised learning and types of classification. Then, we point out the main issues of designing machine learning experiments and their performance evaluation. Finally, we introduce some supervised learning methods.

  20. Machine Learning and Radiology

    PubMed Central

    Wang, Shijun; Summers, Ronald M.

    2012-01-01

    In this paper, we give a short introduction to machine learning and survey its applications in radiology. We focused on six categories of applications in radiology: medical image segmentation, registration, computer aided detection and diagnosis, brain function or activity analysis and neurological disease diagnosis from fMR images, content-based image retrieval systems for CT or MRI images, and text analysis of radiology reports using natural language processing (NLP) and natural language understanding (NLU). This survey shows that machine learning plays a key role in many radiology applications. Machine learning identifies complex patterns automatically and helps radiologists make intelligent decisions on radiology data such as conventional radiographs, CT, MRI, and PET images and radiology reports. In many applications, the performance of machine learning-based automatic detection and diagnosis systems has shown to be comparable to that of a well-trained and experienced radiologist. Technology development in machine learning and radiology will benefit from each other in the long run. Key contributions and common characteristics of machine learning techniques in radiology are discussed. We also discuss the problem of translating machine learning applications to the radiology clinical setting, including advantages and potential barriers. PMID:22465077

  1. The Basic Anaesthesia Machine

    PubMed Central

    Gurudatt, CL

    2013-01-01

    After WTG Morton's first public demonstration in 1846 of use of ether as an anaesthetic agent, for many years anaesthesiologists did not require a machine to deliver anaesthesia to the patients. After the introduction of oxygen and nitrous oxide in the form of compressed gases in cylinders, there was a necessity for mounting these cylinders on a metal frame. This stimulated many people to attempt to construct the anaesthesia machine. HEG Boyle in the year 1917 modified the Gwathmey's machine and this became popular as Boyle anaesthesia machine. Though a lot of changes have been made for the original Boyle machine still the basic structure remains the same. All the subsequent changes which have been brought are mainly to improve the safety of the patients. Knowing the details of the basic machine will make the trainee to understand the additional improvements. It is also important for every practicing anaesthesiologist to have a thorough knowledge of the basic anaesthesia machine for safe conduct of anaesthesia. PMID:24249876

  2. The basic anaesthesia machine.

    PubMed

    Gurudatt, Cl

    2013-09-01

    After WTG Morton's first public demonstration in 1846 of use of ether as an anaesthetic agent, for many years anaesthesiologists did not require a machine to deliver anaesthesia to the patients. After the introduction of oxygen and nitrous oxide in the form of compressed gases in cylinders, there was a necessity for mounting these cylinders on a metal frame. This stimulated many people to attempt to construct the anaesthesia machine. HEG Boyle in the year 1917 modified the Gwathmey's machine and this became popular as Boyle anaesthesia machine. Though a lot of changes have been made for the original Boyle machine still the basic structure remains the same. All the subsequent changes which have been brought are mainly to improve the safety of the patients. Knowing the details of the basic machine will make the trainee to understand the additional improvements. It is also important for every practicing anaesthesiologist to have a thorough knowledge of the basic anaesthesia machine for safe conduct of anaesthesia.

  3. Machine Tool Software

    NASA Technical Reports Server (NTRS)

    1988-01-01

    A NASA-developed software package has played a part in technical education of students who major in Mechanical Engineering Technology at William Rainey Harper College. Professor Hack has been using (APT) Automatically Programmed Tool Software since 1969 in his CAD/CAM Computer Aided Design and Manufacturing curriculum. Professor Hack teaches the use of APT programming languages for control of metal cutting machines. Machine tool instructions are geometry definitions written in APT Language to constitute a "part program." The part program is processed by the machine tool. CAD/CAM students go from writing a program to cutting steel in the course of a semester.

  4. Quantum Boltzmann Machine

    NASA Astrophysics Data System (ADS)

    Kulchytskyy, Bohdan; Andriyash, Evgeny; Amin, Mohammed; Melko, Roger

    The field of machine learning has been revolutionized by the recent improvements in the training of deep networks. Their architecture is based on a set of stacked layers of simpler modules. One of the most successful building blocks, known as a restricted Boltzmann machine, is an energetic model based on the classical Ising Hamiltonian. In our work, we investigate the benefits of quantum effects on the learning capacity of Boltzmann machines by extending its underlying Hamiltonian with a transverse field. For this purpose, we employ exact and stochastic training procedures on data sets with physical origins.

  5. 16. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to south (90mm lens). Note the large segmental-arched doorway to move locomotives in and out of Machine Shop. - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  6. Tunnel boring machine

    SciTech Connect

    Snyder, L. L.

    1985-07-09

    A tunnel boring machine for controlled boring of a curvilinear tunnel including a rotating cutter wheel mounted on the forward end of a thrust cylinder assembly having a central longitudinal axis aligned with the cutter wheel axis of rotation; the thrust cylinder assembly comprising a cylinder barrel and an extendable and retractable thrust arm received therein. An anchoring assembly is pivotally attached to the rear end of the cylinder barrel for anchoring the machine during a cutting stroke and providing a rear end pivot axis during curved cutting strokes. A pair of laterally extending, extendable and retractable arms are fixedly mounted at a forward portion of the cylinder barrel for providing lateral displacement in a laterally curved cutting mode and for anchoring the machine between cutting strokes and during straight line boring. Forward and rear transverse displacement and support assemblies are provided to facilitate cutting in a transversely curved cutting mode and to facilitate machine movement between cutting strokes.

  7. Molecular Machines: Nanoscale gadgets

    NASA Astrophysics Data System (ADS)

    Garcia-Garibay, Miguel A.

    2008-06-01

    Meeting their biological counterparts halfway, artificial molecular machines embedded in liquid crystals, crystalline solids and mesoporous materials are poised to meet the demands of the next generation of functional materials.

  8. Doubly fed induction machine

    DOEpatents

    Skeist, S. Merrill; Baker, Richard H.

    2005-10-11

    An electro-mechanical energy conversion system coupled between an energy source and an energy load including an energy converter device having a doubly fed induction machine coupled between the energy source and the energy load to convert the energy from the energy source and to transfer the converted energy to the energy load and an energy transfer multiplexer coupled to the energy converter device to control the flow of power or energy through the doubly fed induction machine.

  9. Maraging Steel Machining Improvements

    DTIC Science & Technology

    2007-04-23

    APR 2007 2. REPORT TYPE Technical, Success Story 3. DATES COVERED 01-12-2006 to 23-04-2007 4. TITLE AND SUBTITLE Maraging Steel Machining...consumers of cobalt-strengthened maraging steel . An increase in production requires them to reduce the machining time of certain operations producing... maraging steel ; Success Stories 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 1 18. NUMBER OF PAGES 1 19a. NAME OF RESPONSIBLE

  10. Sealing intersecting vane machines

    DOEpatents

    Martin, Jedd N.; Chomyszak, Stephen M.

    2005-06-07

    The invention provides a toroidal intersecting vane machine incorporating intersecting rotors to form primary and secondary chambers whose porting configurations minimize friction and maximize efficiency. Specifically, it is an object of the invention to provide a toroidal intersecting vane machine that greatly reduces the frictional losses through intersecting surfaces without the need for external gearing by modifying the width of one or both tracks at the point of intermeshing. The inventions described herein relate to these improvements.

  11. Sealing intersecting vane machines

    SciTech Connect

    Martin, Jedd N.; Chomyszak, Stephen M.

    2007-06-05

    The invention provides a toroidal intersecting vane machine incorporating intersecting rotors to form primary and secondary chambers whose porting configurations minimize friction and maximize efficiency. Specifically, it is an object of the invention to provide a toroidal intersecting vane machine that greatly reduces the frictional losses through intersecting surfaces without the need for external gearing by modifying the width of one or both tracks at the point of intermeshing. The inventions described herein relate to these improvements.

  12. Human-machine interactions

    DOEpatents

    Forsythe, J. Chris; Xavier, Patrick G.; Abbott, Robert G.; Brannon, Nathan G.; Bernard, Michael L.; Speed, Ann E.

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  13. Metalworking and machining fluids

    DOEpatents

    Erdemir, Ali; Sykora, Frank; Dorbeck, Mark

    2010-10-12

    Improved boron-based metal working and machining fluids. Boric acid and boron-based additives that, when mixed with certain carrier fluids, such as water, cellulose and/or cellulose derivatives, polyhydric alcohol, polyalkylene glycol, polyvinyl alcohol, starch, dextrin, in solid and/or solvated forms result in improved metalworking and machining of metallic work pieces. Fluids manufactured with boric acid or boron-based additives effectively reduce friction, prevent galling and severe wear problems on cutting and forming tools.

  14. Could a machine think

    SciTech Connect

    Churchland, P.M.; Churchland, P.S. )

    1990-01-01

    There are many reasons for saying yes. One of the earliest and deepest reason lay in two important results in computational theory. The first was Church's thesis, which states that every effectively computable function is recursively computable. The second important result was Alan M. Turing's demonstration that any recursively computable function can be computed in finite time by a maximally simple sort of symbol-manipulating machine that has come to be called a universal Turing machine. This machine is guided by a set of recursively applicable rules that are sensitive to the identity, order and arrangement of the elementary symbols it encounters as input. The authors reject the Turing test as a sufficient condition for conscious intelligence. They base their position of the specific behavioral failures of the classical SM machines and on the specific virtues of machines with a more brain-like architecture. These contrasts show that certain computational strategies have vast and decisive advantages over others where typical cognitive tasks are concerned, advantages that are empirically inescapable. Clearly, the brain is making systematic use of these computational advantage. But it need not be the only physical system capable of doing so. Artificial intelligence, in a nonbiological but massively parallel machine, remain a compelling and discernible prospect.

  15. The Knife Machine. Module 15.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

    This module on the knife machine, one in a series dealing with industrial sewing machines, their attachments, and operation, covers one topic: performing special operations on the knife machine (a single needle or multi-needle machine which sews and cuts at the same time). These components are provided: an introduction, directions, an objective,…

  16. Non-traditional machining techniques

    SciTech Connect

    Day, Robert D; Fierro, Frank; Garcia, Felix P; Hatch, Douglass J; Randolph, Randall B; Reardon, Patrick T; Rivera, Gerald

    2008-01-01

    During the course of machining targets for various experiments it sometimes becomes necessary to adapt fixtures or machines, which are designed for one function, to another function. When adapting a machine or fixture is not adequate, it may be necessary to acquire a machine specifically designed to produce the component required. In addition to the above scenarios, the features of a component may dictate that multi-step machining processes are necessary to produce the component. This paper discusses the machining of four components where adaptation, specialized machine design, or multi-step processes were necessary to produce the components.

  17. Extreme ultraviolet lithography machine

    DOEpatents

    Tichenor, Daniel A.; Kubiak, Glenn D.; Haney, Steven J.; Sweeney, Donald W.

    2000-01-01

    An extreme ultraviolet lithography (EUVL) machine or system for producing integrated circuit (IC) components, such as transistors, formed on a substrate. The EUVL machine utilizes a laser plasma point source directed via an optical arrangement onto a mask or reticle which is reflected by a multiple mirror system onto the substrate or target. The EUVL machine operates in the 10-14 nm wavelength soft x-ray photon. Basically the EUV machine includes an evacuated source chamber, an evacuated main or project chamber interconnected by a transport tube arrangement, wherein a laser beam is directed into a plasma generator which produces an illumination beam which is directed by optics from the source chamber through the connecting tube, into the projection chamber, and onto the reticle or mask, from which a patterned beam is reflected by optics in a projection optics (PO) box mounted in the main or projection chamber onto the substrate. In one embodiment of a EUVL machine, nine optical components are utilized, with four of the optical components located in the PO box. The main or projection chamber includes vibration isolators for the PO box and a vibration isolator mounting for the substrate, with the main or projection chamber being mounted on a support structure and being isolated.

  18. The Bearingless Electrical Machine

    NASA Technical Reports Server (NTRS)

    Bichsel, J.

    1992-01-01

    Electromagnetic bearings allow the suspension of solids. For rotary applications, the most important physical effect is the force of a magnetic circuit to a high permeable armature, called the MAXWELL force. Contrary to the commonly used MAXWELL bearings, the bearingless electrical machine will take advantage of the reaction force of a conductor carrying a current in a magnetic field. This kind of force, called Lorentz force, generates the torque in direct current, asynchronous and synchronous machines. The magnetic field, which already exists in electrical machines and helps to build up the torque, can also be used for the suspension of the rotor. Besides the normal winding of the stator, a special winding was added, which generates forces for levitation. So a radial bearing, which is integrated directly in the active part of the machine, and the motor use the laminated core simultaneously. The winding was constructed for the levitating forces in a special way so that commercially available standard ac inverters for drives can be used. Besides wholly magnetic suspended machines, there is a wide range of applications for normal drives with ball bearings. Resonances of the rotor, especially critical speeds, can be damped actively.

  19. Micro-machined resonator

    DOEpatents

    Godshall, N.A.; Koehler, D.R.; Liang, A.Y.; Smith, B.K.

    1993-03-30

    A micro-machined resonator, typically quartz, with upper and lower micro-machinable support members, or covers, having etched wells which may be lined with conductive electrode material, between the support members is a quartz resonator having an energy trapping quartz mesa capacitively coupled to the electrode through a diaphragm; the quartz resonator is supported by either micro-machined cantilever springs or by thin layers extending over the surfaces of the support. If the diaphragm is rigid, clock applications are available, and if the diaphragm is resilient, then transducer applications can be achieved. Either the thin support layers or the conductive electrode material can be integral with the diaphragm. In any event, the covers are bonded to form a hermetic seal and the interior volume may be filled with a gas or may be evacuated. In addition, one or both of the covers may include oscillator and interface circuitry for the resonator.

  20. Micro-machined resonator

    DOEpatents

    Godshall, Ned A.; Koehler, Dale R.; Liang, Alan Y.; Smith, Bradley K.

    1993-01-01

    A micro-machined resonator, typically quartz, with upper and lower micro-machinable support members, or covers, having etched wells which may be lined with conductive electrode material, between the support members is a quartz resonator having an energy trapping quartz mesa capacitively coupled to the electrode through a diaphragm; the quartz resonator is supported by either micro-machined cantilever springs or by thin layers extending over the surfaces of the support. If the diaphragm is rigid, clock applications are available, and if the diaphragm is resilient, then transducer applications can be achieved. Either the thin support layers or the conductive electrode material can be integral with the diaphragm. In any event, the covers are bonded to form a hermetic seal and the interior volume may be filled with a gas or may be evacuated. In addition, one or both of the covers may include oscillator and interface circuitry for the resonator.

  1. The Bateman Flotation Machine

    SciTech Connect

    Bezuidenhout, G.

    1995-12-31

    The newly developed Bateman Flotation Machine has proven its versatility in roughing and cleaning flotation circuits. This mechanical flotation machine has the dual performance capability of suspending solids and dispersing air at relatively low power inputs without compromising these two important fundamentals. This new development has been successfully marketed to a wide cross section of concentrator mineral processes. The mechanical design of the flotation mechanism has been optimized to reduce operational costs and to lower manufacturing costs. Production process environments were utilized for verification of the scale-up of each cell volume size rated mechanism. These thorough investigations produced performance data which could be accurately quoted. This paper is a historical account of the Batement Flotation Machine. Technical details of the development are covered with descriptions of the operational applications.

  2. Brown coal preparation machines

    SciTech Connect

    Bleckmann, H.; Sitte, W.; Kellerwessel, H.

    1981-05-01

    Lignite usually requires comminuting and screening before being used as a fuel in power plants. Reduction machines normally used for coarse crushing bituminous coal, such as jaw crushers, roll crushers, and impact crushers, are not generally suitable for lignite as they require a brittle feed and large grain size. In contrast to these requirements, lignite can be easily compressed and has a small grain size. Therefore, special crusher types have been developed for the coarse reduction of lignite. These machines resemble roll crushers but subject the feed to shearing and tearing forces rather than to compressive stress. It is often necessary to screen the lignite to remove the undersize or to limit the maximum particle size before the next comminution process. Screening the lignite is a particularly difficult operation due to the high water content and the presence of clay minerals which tend to clog the screening machines. These problems can be overcome with multi-roll sizers.

  3. Machining in Microgravity

    NASA Astrophysics Data System (ADS)

    Vincent, Graylan

    2003-01-01

    A CNC mill was flown aboard NASA's KC-135 ``Weightless Wonder'' microgravity research aircraft to investigate the effect of gravity on the machining process and to demonstrate the feasibility and functionality of a CNC mill in a weightless environment, such as aboard the International Space Station. The experiment hypothesis was that the surface roughness of milling cuts made in microgravity would be of higher quality than cuts made in a gravitational environment due to increased chip removal. The technical problems associated with microgravity machining (such as the chip removal and collection process), and the engineering solutions to these problems were also evaluated in this experiment.

  4. New photolithography stepping machine

    SciTech Connect

    Hale, L.; Klingmann, J.; Markle, D.

    1995-03-08

    A joint development project to design a new photolithography steeping machine capable of 150 nanometer overlay accuracy was completed by Ultratech Stepper and the Lawrence Livermore National Laboratory. The principal result of the project is a next-generation product that will strengthen the US position in step-and-repeat photolithography. The significant challenges addressed and solved in the project are the subject of this report. Design methods and new devices that have broader application to precision machine design are presented in greater detail while project specific information serves primarily as background and motivation.

  5. Intersecting vane machines

    SciTech Connect

    Bailey, H. Sterling; Chomyszak, Stephen M.

    2007-01-16

    The invention provides a toroidal intersecting vane machine incorporating intersecting rotors to form primary and secondary chambers whose porting configurations minimize friction and maximize efficiency. Specifically, it is an object of the invention to provide a toroidal intersecting vane machine that greatly reduces the frictional losses through meshing surfaces without the need for external gearing by modifying the function of one or the other of the rotors from that of "fluid moving" to that of "valving" thereby reducing the pressure loads and associated inefficiencies at the interface of the meshing surfaces. The inventions described herein relate to these improvements.

  6. Paradigms for machine learning

    NASA Technical Reports Server (NTRS)

    Schlimmer, Jeffrey C.; Langley, Pat

    1991-01-01

    Five paradigms are described for machine learning: connectionist (neural network) methods, genetic algorithms and classifier systems, empirical methods for inducing rules and decision trees, analytic learning methods, and case-based approaches. Some dimensions are considered along with these paradigms vary in their approach to learning, and the basic methods are reviewed that are used within each framework, together with open research issues. It is argued that the similarities among the paradigms are more important than their differences, and that future work should attempt to bridge the existing boundaries. Finally, some recent developments in the field of machine learning are discussed, and their impact on both research and applications is examined.

  7. Automated fiber pigtailing machine

    DOEpatents

    Strand, Oliver T.; Lowry, Mark E.

    1999-01-01

    The Automated Fiber Pigtailing Machine (AFPM) aligns and attaches optical fibers to optoelectonic (OE) devices such as laser diodes, photodiodes, and waveguide devices without operator intervention. The so-called pigtailing process is completed with sub-micron accuracies in less than 3 minutes. The AFPM operates unattended for one hour, is modular in design and is compatible with a mass production manufacturing environment. This machine can be used to build components which are used in military aircraft navigation systems, computer systems, communications systems and in the construction of diagnostics and experimental systems.

  8. Automated fiber pigtailing machine

    DOEpatents

    Strand, O.T.; Lowry, M.E.

    1999-01-05

    The Automated Fiber Pigtailing Machine (AFPM) aligns and attaches optical fibers to optoelectronic (OE) devices such as laser diodes, photodiodes, and waveguide devices without operator intervention. The so-called pigtailing process is completed with sub-micron accuracies in less than 3 minutes. The AFPM operates unattended for one hour, is modular in design and is compatible with a mass production manufacturing environment. This machine can be used to build components which are used in military aircraft navigation systems, computer systems, communications systems and in the construction of diagnostics and experimental systems. 26 figs.

  9. Autonomous quantum thermodynamic machines

    NASA Astrophysics Data System (ADS)

    Tonner, Friedemann; Mahler, Günter

    2005-12-01

    We investigate the dynamics of a quantum system consisting of a single spin coupled to an oscillator and sandwiched between two thermal baths at different temperatures. By means of an adequately designed Lindblad equation, it is shown that this device can function as a thermodynamic machine exhibiting Carnot-type cycles. For the present model, this means that when run as a heat engine, coherent motion of the oscillator is amplified. Contrary to the quantum computer, such a machine has a quantum as well as a classical limit. Away from the classical limit, it asymptotically approaches a stationary transport scenario.

  10. Precision Robotic Assembly Machine

    ScienceCinema

    None

    2016-07-12

    The world's largest laser system is the National Ignition Facility (NIF), located at Lawrence Livermore National Laboratory. NIF's 192 laser beams are amplified to extremely high energy, and then focused onto a tiny target about the size of a BB, containing frozen hydrogen gas. The target must be perfectly machined to incredibly demanding specifications. The Laboratory's scientists and engineers have developed a device called the "Precision Robotic Assembly Machine" for this purpose. Its unique design won a prestigious R&D-100 award from R&D Magazine.

  11. 12. Photocopied August 1978. CHANNELING MACHINES, NOVEMBER 1898. THESE MACHINES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopied August 1978. CHANNELING MACHINES, NOVEMBER 1898. THESE MACHINES BLOCKED OUT SECTIONS IN THE ROCK CUT IN PREPARATION FOR DRILLING AND BLASTING. (17) - Michigan Lake Superior Power Company, Portage Street, Sault Ste. Marie, Chippewa County, MI

  12. BRASS FOUNDRY MACHINE ROOM USED TO MACHINE CAST BRONZE PIECES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BRASS FOUNDRY MACHINE ROOM USED TO MACHINE CAST BRONZE PIECES FOR VALVES AND PREPARE BRONZE VALVE BODIES FOR ASSEMBLY. - Stockham Pipe & Fittings Company, Brass Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  13. 14. Machine in north 1922 section of Building 59. Machine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Machine in north 1922 section of Building 59. Machine is 24' Jointer made by Oliver Machinery Co. Camera pointed E. - Puget Sound Naval Shipyard, Pattern Shop, Farragut Avenue, Bremerton, Kitsap County, WA

  14. 42. MACHINE SHOP Machine shop area with small parts bins ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. MACHINE SHOP Machine shop area with small parts bins on the right and pipe storage racks on the left. Remains of the power drive system are suspended from the ceiling. - Hovden Cannery, 886 Cannery Row, Monterey, Monterey County, CA

  15. Machine speech and speaking about machines

    SciTech Connect

    Nye, A.

    1996-12-31

    Current philosophy of language prides itself on scientific status. It boasts of being no longer contaminated with queer mental entities or idealist essences. It theorizes language as programmable variants of formal semantic systems, reimaginable either as the properly epiphenomenal machine functions of computer science or the properly material neural networks of physiology. Whether or not such models properly capture the physical workings of a living human brain is a question that scientists will have to answer. I, as a philosopher, come at the problem from another direction. Does contemporary philosophical semantics, in its dominant truth-theoretic and related versions, capture actual living human thought as it is experienced, or does it instead reflect, regardless of (perhaps dubious) scientific credentials, pathology of thought, a pathology with a disturbing social history.

  16. Machine Aids to Translation.

    ERIC Educational Resources Information Center

    Brinkmann, Karl-Heinz

    1981-01-01

    Describes the TEAM Program System of the Siemens Language Services Department, particularly the main features of its terminology data bank. Discusses criteria to which stored terminology must conform and methods of data bank utilization. Concludes by summarizing the consequences that machine-aided translation development has had for the…

  17. Biomimetic machine vision system.

    PubMed

    Harman, William M; Barrett, Steven F; Wright, Cameron H G; Wilcox, Michael

    2005-01-01

    Real-time application of digital imaging for use in machine vision systems has proven to be prohibitive when used within control systems that employ low-power single processors without compromising the scope of vision or resolution of captured images. Development of a real-time machine analog vision system is the focus of research taking place at the University of Wyoming. This new vision system is based upon the biological vision system of the common house fly. Development of a single sensor is accomplished, representing a single facet of the fly's eye. This new sensor is then incorporated into an array of sensors capable of detecting objects and tracking motion in 2-D space. This system "preprocesses" incoming image data resulting in minimal data processing to determine the location of a target object. Due to the nature of the sensors in the array, hyperacuity is achieved thereby eliminating resolutions issues found in digital vision systems. In this paper, we will discuss the biological traits of the fly eye and the specific traits that led to the development of this machine vision system. We will also discuss the process of developing an analog based sensor that mimics the characteristics of interest in the biological vision system. This paper will conclude with a discussion of how an array of these sensors can be applied toward solving real-world machine vision issues.

  18. The Art Machine.

    ERIC Educational Resources Information Center

    Vertelney, Harry; Grossberger, Lucia

    1983-01-01

    Introduces educators to possibilities of computer graphics using an inexpensive computer system which takes advantage of existing equipment (35mm camera, super 8 movie camera, VHS video cassette recorder). The concept of the "art machine" is explained, highlighting input and output devices (X-Y plotter, graphic tablets, video…

  19. Cybernetic anthropomorphic machine systems

    NASA Technical Reports Server (NTRS)

    Gray, W. E.

    1974-01-01

    Functional descriptions are provided for a number of cybernetic man machine systems that augment the capacity of normal human beings in the areas of strength, reach or physical size, and environmental interaction, and that are also applicable to aiding the neurologically handicapped. Teleoperators, computer control, exoskeletal devices, quadruped vehicles, space maintenance systems, and communications equipment are considered.

  20. Copy Machine Art.

    ERIC Educational Resources Information Center

    Sommer, Jean

    1984-01-01

    Images created with copy machines make children feel successful, as their work acquires the authority of being printed. Students can learn advanced processes like electrostatic image-making and can get involved in projects like making collages. They acquire an appreciation of design and of two-dimensional composition. (CS)

  1. Working with Simple Machines

    ERIC Educational Resources Information Center

    Norbury, John W.

    2006-01-01

    A set of examples is provided that illustrate the use of work as applied to simple machines. The ramp, pulley, lever and hydraulic press are common experiences in the life of a student, and their theoretical analysis therefore makes the abstract concept of work more real. The mechanical advantage of each of these systems is also discussed so that…

  2. Protein thin film machines.

    PubMed

    Federici, Stefania; Oliviero, Giulio; Hamad-Schifferli, Kimberly; Bergese, Paolo

    2010-12-01

    We report the first example of microcantilever beams that are reversibly driven by protein thin film machines fueled by cycling the salt concentration of the surrounding solution. We also show that upon the same salinity stimulus the drive can be completely reversed in its direction by introducing a surface coating ligand. Experimental results are throughout discussed within a general yet simple thermodynamic model.

  3. Introduction to Exploring Machines

    ERIC Educational Resources Information Center

    Early Childhood Today, 2006

    2006-01-01

    Young children are fascinated by how things "work." They are at a stage of development where they want to experiment with the many ways to use an object or take things apart and put them back together. In the process of exploring tools and machines, children use the scientific method and problem-solving skills. They observe how things work, wonder…

  4. Support vector machines

    NASA Technical Reports Server (NTRS)

    Garay, Michael J.; Mazzoni, Dominic; Davies, Roger; Wagstaff, Kiri

    2004-01-01

    Support Vector Machines (SVMs) are a type of supervised learning algorith,, other examples of which are Artificial Neural Networks (ANNs), Decision Trees, and Naive Bayesian Classifiers. Supervised learning algorithms are used to classify objects labled by a 'supervisor' - typically a human 'expert.'.

  5. Laser machining of explosives

    DOEpatents

    Perry, Michael D.; Stuart, Brent C.; Banks, Paul S.; Myers, Booth R.; Sefcik, Joseph A.

    2000-01-01

    The invention consists of a method for machining (cutting, drilling, sculpting) of explosives (e.g., TNT, TATB, PETN, RDX, etc.). By using pulses of a duration in the range of 5 femtoseconds to 50 picoseconds, extremely precise and rapid machining can be achieved with essentially no heat or shock affected zone. In this method, material is removed by a nonthermal mechanism. A combination of multiphoton and collisional ionization creates a critical density plasma in a time scale much shorter than electron kinetic energy is transferred to the lattice. The resulting plasma is far from thermal equilibrium. The material is in essence converted from its initial solid-state directly into a fully ionized plasma on a time scale too short for thermal equilibrium to be established with the lattice. As a result, there is negligible heat conduction beyond the region removed resulting in negligible thermal stress or shock to the material beyond a few microns from the laser machined surface. Hydrodynamic expansion of the plasma eliminates the need for any ancillary techniques to remove material and produces extremely high quality machined surfaces. There is no detonation or deflagration of the explosive in the process and the material which is removed is rendered inert.

  6. 8. VIEW OF THE MACHINE SHOP. BY 1966, THE MACHINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF THE MACHINE SHOP. BY 1966, THE MACHINE SHOP HANDLED PRIMARILY STAINLESS STEEL COMPONENTS, WHICH WERE SENT TO THE MACHINE SHOP TO BE FORMED INTO THEIR FINAL SHAPES. (7/24/70) - Rocky Flats Plant, General Manufacturing, Support, Records-Central Computing, Southern portion of Plant, Golden, Jefferson County, CO

  7. Hinged Shields for Machine Tools

    NASA Technical Reports Server (NTRS)

    Lallande, J. B.; Poland, W. W.; Tull, S.

    1985-01-01

    Flaps guard against flying chips, but fold away for tool setup. Clear plastic shield in position to intercept flying chips from machine tool and retracted to give operator access to workpiece. Machine shops readily make such shields for own use.

  8. Automatically-Programed Machine Tools

    NASA Technical Reports Server (NTRS)

    Purves, L.; Clerman, N.

    1985-01-01

    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  9. Isomap based supporting vector machine

    NASA Astrophysics Data System (ADS)

    Liang, W. N.

    2015-12-01

    This research presents a new isomap based supporting vector machine method. Isomap is a dimension reduction method which is able to analyze nonlinear relationship of data on manifolds. Accordingly, support vector machine is established on the isomap manifold to classify given and predict unknown data. A case study of the isomap based supporting vector machine for environmental planning problems is conducted.

  10. Interferometer systems in machine industry

    NASA Astrophysics Data System (ADS)

    Rzepka, Janusz; Pienkowski, Janusz; Sambor, Slawomir; Budzyn, Grzegorz

    2003-10-01

    In the report the arrangements of laser interferometers for machine history are presented; the laser interferometer LSP30 for investigation of geometry of machine tools, the setup for inspection of ball screw and laser liner for CNC machine. Outstanding feature of the interferometers is the stabilization system of laser frequency using surface stabilized ferroelectric liquid cells (SSFLC).

  11. Machine Shop Fundamentals: Part I.

    ERIC Educational Resources Information Center

    Kelly, Michael G.; And Others

    These instructional materials were developed and designed for secondary and adult limited English proficient students enrolled in machine tool technology courses. Part 1 includes 24 lessons covering introduction, safety and shop rules, basic machine tools, basic machine operations, measurement, basic blueprint reading, layout, and bench tools.…

  12. A Boltzmann machine for the organization of intelligent machines

    NASA Technical Reports Server (NTRS)

    Moed, Michael C.; Saridis, George N.

    1989-01-01

    In the present technological society, there is a major need to build machines that would execute intelligent tasks operating in uncertain environments with minimum interaction with a human operator. Although some designers have built smart robots, utilizing heuristic ideas, there is no systematic approach to design such machines in an engineering manner. Recently, cross-disciplinary research from the fields of computers, systems AI and information theory has served to set the foundations of the emerging area of the design of intelligent machines. Since 1977 Saridis has been developing an approach, defined as Hierarchical Intelligent Control, designed to organize, coordinate and execute anthropomorphic tasks by a machine with minimum interaction with a human operator. This approach utilizes analytical (probabilistic) models to describe and control the various functions of the intelligent machine structured by the intuitively defined principle of Increasing Precision with Decreasing Intelligence (IPDI) (Saridis 1979). This principle, even though resembles the managerial structure of organizational systems (Levis 1988), has been derived on an analytic basis by Saridis (1988). The purpose is to derive analytically a Boltzmann machine suitable for optimal connection of nodes in a neural net (Fahlman, Hinton, Sejnowski, 1985). Then this machine will serve to search for the optimal design of the organization level of an intelligent machine. In order to accomplish this, some mathematical theory of the intelligent machines will be first outlined. Then some definitions of the variables associated with the principle, like machine intelligence, machine knowledge, and precision will be made (Saridis, Valavanis 1988). Then a procedure to establish the Boltzmann machine on an analytic basis will be presented and illustrated by an example in designing the organization level of an Intelligent Machine. A new search technique, the Modified Genetic Algorithm, is presented and proved

  13. Engineering molecular machines

    NASA Astrophysics Data System (ADS)

    Erman, Burak

    2016-04-01

    Biological molecular motors use chemical energy, mostly in the form of ATP hydrolysis, and convert it to mechanical energy. Correlated thermal fluctuations are essential for the function of a molecular machine and it is the hydrolysis of ATP that modifies the correlated fluctuations of the system. Correlations are consequences of the molecular architecture of the protein. The idea that synthetic molecular machines may be constructed by designing the proper molecular architecture is challenging. In their paper, Sarkar et al (2016 New J. Phys. 18 043006) propose a synthetic molecular motor based on the coarse grained elastic network model of proteins and show by numerical simulations that motor function is realized, ranging from deterministic to thermal, depending on temperature. This work opens up a new range of possibilities of molecular architecture based engine design.

  14. Machining fiber-reinforced composites

    NASA Astrophysics Data System (ADS)

    Komanduri, Ranga

    1993-04-01

    Compared to high tool wear and high costs of tooling of fiber-reinforced composites (FRCs), noncontact material-removal processes offer attractive alternative. Noncontact machining methods can also minimize dust, noise, and extensive plastic deformation and consequent heat generation associated with conventional machining of FRCs, espacially those with an epoxy matrix. The paper describes the principles involved in and the details of machining of FRCs by laser machining, water jet-cutting and abrasive water jet-cutting, and electrical discharge machining of composites, as well as the limitations of each method.

  15. Safety features in anaesthesia machine.

    PubMed

    Subrahmanyam, M; Mohan, S

    2013-09-01

    Anaesthesia is one of the few sub-specialties of medicine, which has quickly adapted technology to improve patient safety. This application of technology can be seen in patient monitoring, advances in anaesthesia machines, intubating devices, ultrasound for visualisation of nerves and vessels, etc., Anaesthesia machines have come a long way in the last 100 years, the improvements being driven both by patient safety as well as functionality and economy of use. Incorporation of safety features in anaesthesia machines and ensuring that a proper check of the machine is done before use on a patient ensures patient safety. This review will trace all the present safety features in the machine and their evolution.

  16. Quantum Virtual Machine (QVM)

    SciTech Connect

    McCaskey, Alexander J.

    2016-11-18

    There is a lack of state-of-the-art HPC simulation tools for simulating general quantum computing. Furthermore, there are no real software tools that integrate current quantum computers into existing classical HPC workflows. This product, the Quantum Virtual Machine (QVM), solves this problem by providing an extensible framework for pluggable virtual, or physical, quantum processing units (QPUs). It enables the execution of low level quantum assembly codes and returns the results of such executions.

  17. Swinging Atwood's Machine

    NASA Astrophysics Data System (ADS)

    Tufillaro, Nicholas B.; Abbott, Tyler A.; Griffiths, David J.

    1984-10-01

    We examine the motion of an Atwood's Machine in which one of the masses is allowed to swing in a plane. Computer studies reveal a rich variety of trajectories. The orbits are classified (bounded, periodic, singular, and terminating), and formulas for the critical mass ratios are developed. Perturbative techniques yield good approximations to the computer-generated trajectories. The model constitutes a simple example of a nonlinear dynamical system with two degrees of freedom.

  18. Making Atwood's machine ``work''

    NASA Astrophysics Data System (ADS)

    Johnson, Gordon O.

    2001-03-01

    PASCO scientific's Smart Pulley™, a lightweight, low-friction pulley and a photogate, begs to be used as an Atwood's machine to determine the acceleration of gravity, g. Unfortunately ignoring the mass and friction of the pulley results in poor values of g. In this paper a procedure is outlined that includes the effects of the pulley's inertia and friction. As a result, the value of g may be determined to an accuracy of 0.1%.

  19. Machine Learning in Medicine.

    PubMed

    Deo, Rahul C

    2015-11-17

    Spurred by advances in processing power, memory, storage, and an unprecedented wealth of data, computers are being asked to tackle increasingly complex learning tasks, often with astonishing success. Computers have now mastered a popular variant of poker, learned the laws of physics from experimental data, and become experts in video games - tasks that would have been deemed impossible not too long ago. In parallel, the number of companies centered on applying complex data analysis to varying industries has exploded, and it is thus unsurprising that some analytic companies are turning attention to problems in health care. The purpose of this review is to explore what problems in medicine might benefit from such learning approaches and use examples from the literature to introduce basic concepts in machine learning. It is important to note that seemingly large enough medical data sets and adequate learning algorithms have been available for many decades, and yet, although there are thousands of papers applying machine learning algorithms to medical data, very few have contributed meaningfully to clinical care. This lack of impact stands in stark contrast to the enormous relevance of machine learning to many other industries. Thus, part of my effort will be to identify what obstacles there may be to changing the practice of medicine through statistical learning approaches, and discuss how these might be overcome.

  20. Universal Memcomputing Machines.

    PubMed

    Traversa, Fabio Lorenzo; Di Ventra, Massimiliano

    2015-11-01

    We introduce the notion of universal memcomputing machines (UMMs): a class of brain-inspired general-purpose computing machines based on systems with memory, whereby processing and storing of information occur on the same physical location. We analytically prove that the memory properties of UMMs endow them with universal computing power (they are Turing-complete), intrinsic parallelism, functional polymorphism, and information overhead, namely, their collective states can support exponential data compression directly in memory. We also demonstrate that a UMM has the same computational power as a nondeterministic Turing machine, namely, it can solve nondeterministic polynomial (NP)-complete problems in polynomial time. However, by virtue of its information overhead, a UMM needs only an amount of memory cells (memprocessors) that grows polynomially with the problem size. As an example, we provide the polynomial-time solution of the subset-sum problem and a simple hardware implementation of the same. Even though these results do not prove the statement NP = P within the Turing paradigm, the practical realization of these UMMs would represent a paradigm shift from the present von Neumann architectures, bringing us closer to brain-like neural computation.

  1. Architectures for intelligent machines

    NASA Technical Reports Server (NTRS)

    Saridis, George N.

    1991-01-01

    The theory of intelligent machines has been recently reformulated to incorporate new architectures that are using neural and Petri nets. The analytic functions of an intelligent machine are implemented by intelligent controls, using entropy as a measure. The resulting hierarchical control structure is based on the principle of increasing precision with decreasing intelligence. Each of the three levels of the intelligent control is using different architectures, in order to satisfy the requirements of the principle: the organization level is moduled after a Boltzmann machine for abstract reasoning, task planning and decision making; the coordination level is composed of a number of Petri net transducers supervised, for command exchange, by a dispatcher, which also serves as an interface to the organization level; the execution level, include the sensory, planning for navigation and control hardware which interacts one-to-one with the appropriate coordinators, while a VME bus provides a channel for database exchange among the several devices. This system is currently implemented on a robotic transporter, designed for space construction at the CIRSSE laboratories at the Rensselaer Polytechnic Institute. The progress of its development is reported.

  2. CNC electrical discharge machining centers

    SciTech Connect

    Jaggars, S.R.

    1991-10-01

    Computer numerical control (CNC) electrical discharge machining (EDM) centers were investigated to evaluate the application and cost effectiveness of establishing this capability at Allied-Signal Inc., Kansas City Division (KCD). In line with this investigation, metal samples were designed, prepared, and machined on an existing 15-year-old EDM machine and on two current technology CNC EDM machining centers at outside vendors. The results were recorded and evaluated. The study revealed that CNC EDM centers are a capability that should be established at KCD. From the information gained, a machine specification was written and a shop was purchased and installed in the Engineering Shop. The older machine was exchanged for a new model. Additional machines were installed in the Tool Design and Fabrication and Precision Microfinishing departments. The Engineering Shop machine will be principally used for the following purposes: producing deep cavities in small corner radii, machining simulated casting models, machining difficult-to-machine materials, and polishing difficult-to-hand polish mold cavities. 2 refs., 18 figs., 3 tabs.

  3. Evaluation of drug treatment in mild hypertension: VA-NHLBI feasibility trial. Plan and preliminary results of a two-year feasibility trial for a multicenter intervention study to evaluate the benefits versus the disadvantages of treating mild hypertension. Prepared for the Veterans Administration-National Heart, Lung, and Blood Institute Study Group for Evaluating Treatment in Mild Hypertension.

    PubMed

    1978-03-30

    A feasibility trial to investigate the practicality of determining the advantages and disadvantages of prompt pharmacologic treatment for mild hypertension was jointly funded by the Veterans Administration and the National Heart, Lung and Blood Institute. Its clinical phase has been completed, and it demonstrated 1. that the required relatively young asymptomatic population could be enrolled in the study and 2. that it could be persuaded to adhere to the protocol for 2 years; however, it was evident that intensive efforts would be required in both areas. The feasibility trial screened almost 120,000 potential subjects over a period of 16 months to randomize about 1,000 subjects at four clinical centers. These men and women were 21 to 50 years old, had diastolic pressures from 85 to 105 mm Hg as outpatients, and had no evidence of cardiovascular renal abnormalities. They were randomized in double-blind fashion into active drug therapy and placebo groups. Stepped care therapy involved 50 mg chlorthalidone (Step 1), 100 mg chlorthalidone (Step 2) and 100 chlorthalidone plus 0.25 mg reserpine (Step 3). Death, myocardial infarction, stroke, angina pectoris, and congestive heart failure were the "major" morbid events that were looked for; also recorded were "minor" morbid events consisting primarily of electrocardiographic arrhythmias. The development of significant hypertension was considered a treatment failure. Side effects were carefully tabulated in both active drug and placebo groups. The study revealed an average drop in diastolic pressure of almost 12 mm Hg for active drug group and less than half of that for the placebo group; once established 6 months after randomization, the new pressure levels persisted almost without change throughout the study. Although the feasibility trial was not designed to answer the primary question regarding the benefits of treatment, the events were tabulated for each group. A total of 12 placebo-treated subjects developed

  4. 15. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Interior, Machine Shop, Roundhouse Machine Shop Extension, Southern Pacific Railroad Carlin Shops, view to northeast (90mm lens). The arched cutouts in the bottom chords of the roof trusses were necessary to provide clearance for the smokestacks of steam locomotives, and also mark the location of the former inspection pit in the floor (now filled in and covered by a new concrete floor). - Southern Pacific Railroad, Carlin Shops, Roundhouse Machine Shop Extension, Foot of Sixth Street, Carlin, Elko County, NV

  5. Hearts, lungs, and children: a physiologist returns to kindergarten.

    PubMed

    Curran-Everett, D

    1995-12-01

    Scientific illiteracy is a prevalent problem: between kindergarten and high school, most children progressively lose their inherent affinity for science exploration. The correction of this deficiency requires vigorous participation by the scientific community. This paper details my experiences introducing kindergartners to the basics of cardiorespiratory physiology: pulmonary ventilation and circulatory transport of oxygen. More important, my presentation gives children an opportunity to participate in the process of scientific inquiry and to discover and explore the mystique of real hearts and lungs. The children and their teachers truly enjoy the demonstration. In particular, my use of animal organs meets with phenomenal success: the children are enchanted by my inflation and their exploration of pig lungs, and one teacher told me weeks afterward that her students were still "bragging of how they touched a real heart and lung." Young children delight in science exploration and marvel at the wonder inherent to physiology. Armed with an intriguing hands-on presentation and a spirit of adventure and fun, any scientist can return to kindergarten. The rewards are likely to be profound.

  6. Hearts, Lungs, and Children: A Physiologist Returns To Kindergarten.

    ERIC Educational Resources Information Center

    Curran-Everett, Douglas

    1995-01-01

    Details the experiences of a physiologist introducing kindergartners to the basics of cardiorespiratory physiology including pulmonary ventilation and circulatory transport of oxygen. Describes the demonstration and how it enables children to participate in scientific inquiry. Contains 17 references. (DDR)

  7. Will machines ever think

    NASA Technical Reports Server (NTRS)

    Denning, P. J.

    1986-01-01

    Artificial Intelligence research has come under fire for failing to fulfill its promises. A growing number of AI researchers are reexamining the bases of AI research and are challenging the assumption that intelligent behavior can be fully explained as manipulation of symbols by algorithms. Three recent books -- Mind over Machine (H. Dreyfus and S. Dreyfus), Understanding Computers and Cognition (T. Winograd and F. Flores), and Brains, Behavior, and Robots (J. Albus) -- explore alternatives and open the door to new architectures that may be able to learn skills.

  8. Learning thermodynamics with Boltzmann machines

    NASA Astrophysics Data System (ADS)

    Torlai, Giacomo; Melko, Roger G.

    2016-10-01

    A Boltzmann machine is a stochastic neural network that has been extensively used in the layers of deep architectures for modern machine learning applications. In this paper, we develop a Boltzmann machine that is capable of modeling thermodynamic observables for physical systems in thermal equilibrium. Through unsupervised learning, we train the Boltzmann machine on data sets constructed with spin configurations importance sampled from the partition function of an Ising Hamiltonian at different temperatures using Monte Carlo (MC) methods. The trained Boltzmann machine is then used to generate spin states, for which we compare thermodynamic observables to those computed by direct MC sampling. We demonstrate that the Boltzmann machine can faithfully reproduce the observables of the physical system. Further, we observe that the number of neurons required to obtain accurate results increases as the system is brought close to criticality.

  9. Multiple man-machine interfaces

    NASA Technical Reports Server (NTRS)

    Stanton, L.; Cook, C. W.

    1981-01-01

    The multiple man machine interfaces inherent in military pilot training, their social implications, and the issue of possible negative feedback were explored. Modern technology has produced machines which can see, hear, and touch with greater accuracy and precision than human beings. Consequently, the military pilot is more a systems manager, often doing battle against a target he never sees. It is concluded that unquantifiable human activity requires motivation that is not intrinsic in a machine.

  10. Interaction with Machine Improvisation

    NASA Astrophysics Data System (ADS)

    Assayag, Gerard; Bloch, George; Cont, Arshia; Dubnov, Shlomo

    We describe two multi-agent architectures for an improvisation oriented musician-machine interaction systems that learn in real time from human performers. The improvisation kernel is based on sequence modeling and statistical learning. We present two frameworks of interaction with this kernel. In the first, the stylistic interaction is guided by a human operator in front of an interactive computer environment. In the second framework, the stylistic interaction is delegated to machine intelligence and therefore, knowledge propagation and decision are taken care of by the computer alone. The first framework involves a hybrid architecture using two popular composition/performance environments, Max and OpenMusic, that are put to work and communicate together, each one handling the process at a different time/memory scale. The second framework shares the same representational schemes with the first but uses an Active Learning architecture based on collaborative, competitive and memory-based learning to handle stylistic interactions. Both systems are capable of processing real-time audio/video as well as MIDI. After discussing the general cognitive background of improvisation practices, the statistical modelling tools and the concurrent agent architecture are presented. Then, an Active Learning scheme is described and considered in terms of using different improvisation regimes for improvisation planning. Finally, we provide more details about the different system implementations and describe several performances with the system.

  11. Stacked Extreme Learning Machines.

    PubMed

    Zhou, Hongming; Huang, Guang-Bin; Lin, Zhiping; Wang, Han; Soh, Yeng Chai

    2015-09-01

    Extreme learning machine (ELM) has recently attracted many researchers' interest due to its very fast learning speed, good generalization ability, and ease of implementation. It provides a unified solution that can be used directly to solve regression, binary, and multiclass classification problems. In this paper, we propose a stacked ELMs (S-ELMs) that is specially designed for solving large and complex data problems. The S-ELMs divides a single large ELM network into multiple stacked small ELMs which are serially connected. The S-ELMs can approximate a very large ELM network with small memory requirement. To further improve the testing accuracy on big data problems, the ELM autoencoder can be implemented during each iteration of the S-ELMs algorithm. The simulation results show that the S-ELMs even with random hidden nodes can achieve similar testing accuracy to support vector machine (SVM) while having low memory requirements. With the help of ELM autoencoder, the S-ELMs can achieve much better testing accuracy than SVM and slightly better accuracy than deep belief network (DBN) with much faster training speed.

  12. Earth boring machine

    SciTech Connect

    Durham, M. E.

    1985-11-19

    An earth boring machine for boring straight and level elongated holes through rock-laden earth. The machine includes a stationary elongated frame upon which a first slide is carried. A second slide is carried on the first slide. An elongated auger guiding sleeve is carried adjacent one end of the first slide and has a cutting edge on a remote end thereof. A power-driven auger assembly is carried on the second slide and includes an auger which extends within the guiding sleeve. A cutting tool is carried on the end of the auger adjacent a remote end of the guiding sleeve. An hydraulic cylinder is provided for advancing the first sleeve for driving the cutting edge of the guiding sleeve into the earth while the power driven auger removes the earth as the guiding sleeve is advanced. Another set of hydraulic cylinders are provided for advancing the second slide on the first slide causing the cutting tool to extend out beyond the remote end of the guiding sleeve for cutting through obstructions in the earth when the cutting edge of the guiding sleeve is prevented from moving forward.

  13. Smart Test Machines

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Vern Wedeven, president of Wedeven Associates, developed the WAM4, a computer-aided "smart" test machine for simulating stress on equipment, based on his bearing lubrication expertise gained while working for Lewis Research Center. During his NASA years from the 1970s into the early 1980s, Wedeven initiated an "Interdisciplinary Collaboration in Tribology," an effort that involved NASA, six universities, and several university professors. The NASA-sponsored work provided foundation for Wedeven in 1983 to form his own company. Several versions of the smart test machine, the WAM1, WAM2, and WAM3, have proceeded the current version, WAM4. This computer-controlled device can provide detailed glimpses at gear and bearing points of contact. WAM4 can yield a three-dimensional view of machinery as an operator adds "what-if" thermal and lubrication conditions, contact stress, and surface motion. Along with NASA, a number of firms, including Pratt & Whitney, Caterpillar Tractor, Exxon, and Chevron have approached Wedeven for help on resolving lubrication problems.

  14. Standardized Curriculum for Machine Tool Operation/Machine Shop.

    ERIC Educational Resources Information Center

    Mississippi State Dept. of Education, Jackson. Office of Vocational, Technical and Adult Education.

    Standardized vocational education course titles and core contents for two courses in Mississippi are provided: machine tool operation/machine shop I and II. The first course contains the following units: (1) orientation; (2) shop safety; (3) shop math; (4) measuring tools and instruments; (5) hand and bench tools; (6) blueprint reading; (7)…

  15. Machine Shop Milling Machines. Oklahoma Trade and Industrial Education.

    ERIC Educational Resources Information Center

    Dunn, James

    This curriculum guide provides instructional materials designed to equip students with basic knowledge and skills that will enable them to enter the machine trades at the machine-operator level. The curriculum is designed for use in full-time secondary and postsecondary classes and part-time adult classes. It can also be adapted to open-entry,…

  16. Production Machine Shop Employment Competencies. Part Four: The Milling Machine.

    ERIC Educational Resources Information Center

    Bishart, Gus; Werner, Claire

    Competencies for production machine shop are provided for the fourth of four topic areas: the milling machine. Each competency appears in a one-page format. It is presented as a goal statement followed by one or more "indicator" statements, which are performance objectives describing an ability that, upon attainment, will establish…

  17. The Potential to Machine Superconductors with Electrochemical Machining

    NASA Astrophysics Data System (ADS)

    Leese, Rebecca J.; Ivanov, Atanas; Babu-Nadendla, Hari

    2016-01-01

    Superconductors (SCs), such as gadolinium barium copper oxide, are brittle ceramics which are very difficult to machine conventionally due to the easy propagation of cracks. The cracks formed during conventional machining destroy the superconductive properties of the material. As a result a new method to machine ceramic SCs is needed. In this paper, polarization experiments were conducted in various nonaqueous salt electrolytes to determine whether electrochemical machining (ECM) is a suitable method for machining gadolinium barium copper oxide with silver inclusions (GdBCO-Ag) for the first time. Sodium chloride in formic acid proved to be the best electrolyte for this application with higher dissolution rates and achieving a better surface finish. It was noted that GdBCO-Ag dissolved at higher rates in NaCl in formic acid than in other salt-solvent systems.

  18. Machine performance assessment and enhancement for a hexapod machine

    SciTech Connect

    Mou, J.I.; King, C.

    1998-03-19

    The focus of this study is to develop a sensor fused process modeling and control methodology to model, assess, and then enhance the performance of a hexapod machine for precision product realization. Deterministic modeling technique was used to derive models for machine performance assessment and enhancement. Sensor fusion methodology was adopted to identify the parameters of the derived models. Empirical models and computational algorithms were also derived and implemented to model, assess, and then enhance the machine performance. The developed sensor fusion algorithms can be implemented on a PC-based open architecture controller to receive information from various sensors, assess the status of the process, determine the proper action, and deliver the command to actuators for task execution. This will enhance a hexapod machine`s capability to produce workpieces within the imposed dimensional tolerances.

  19. Machining of uranium and uranium alloys

    SciTech Connect

    Morris, T.O.

    1981-12-14

    Uranium and uranium alloys can be readily machined by conventional methods in the standard machine shop when proper safety and operating techniques are used. Material properties that affect machining processes and recommended machining parameters are discussed. Safety procedures and precautions necessary in machining uranium and uranium alloys are also covered. 30 figures.

  20. Profile machining apparatus

    SciTech Connect

    Fisher, A. J.

    1985-02-26

    The disclosure relates to a profile forming apparatus and in particular a cam grinding machine in which a cam to be ground is mounted for rotation about the axis of the cam shaft in a work-table and a drive motor rotates the cam about its axis at a speed controlled by a predetermined programme. The work-table is mounted for rocking movement about an axis parallel to the cam shaft axis to move towards and away from the rotating grinding wheel which grinds cam surfaces spaced apart along the camshaft. The work-table is driven positively about its axis by a reversible drive motor in accordance with a further programme to rock the camshaft towards and away from the axis of the grinding wheel as the camshaft rotates and thereby determine the shape and dimensions of the profile to which the cam is ground.

  1. Quantum adiabatic machine learning

    NASA Astrophysics Data System (ADS)

    Pudenz, Kristen L.; Lidar, Daniel A.

    2013-05-01

    We develop an approach to machine learning and anomaly detection via quantum adiabatic evolution. This approach consists of two quantum phases, with some amount of classical preprocessing to set up the quantum problems. In the training phase we identify an optimal set of weak classifiers, to form a single strong classifier. In the testing phase we adiabatically evolve one or more strong classifiers on a superposition of inputs in order to find certain anomalous elements in the classification space. Both the training and testing phases are executed via quantum adiabatic evolution. All quantum processing is strictly limited to two-qubit interactions so as to ensure physical feasibility. We apply and illustrate this approach in detail to the problem of software verification and validation, with a specific example of the learning phase applied to a problem of interest in flight control systems. Beyond this example, the algorithm can be used to attack a broad class of anomaly detection problems.

  2. An Experimental LISP Machine

    NASA Astrophysics Data System (ADS)

    Lun, Wang

    1987-04-01

    This paper presents a multi-microprocessor LISP machine whose goal is to exploit the inherent parallelism in the LISP programs fully. The base architecture is a MIMD architecture based on a hybrid model for combinating data driven, demand driven and VoN Neumann process schemes. The basic evaluation strategy is data driven. Lazy evaluation mechanism is introduced to avoid unnecessary and unsafe computations. An experimental system with the four processor elements has been built in HIT, China. The system consists of a Z80 microcomputer and three TP8O1s interconnected through three buses. Each processor evaluates a part of programs asynchronously. The shared memory is divided into two parts: list cell area and enviroment area, each of which has the indepen-dent common bus to avoid the bus bottleneck.

  3. Extremal quantum cloning machines

    SciTech Connect

    Chiribella, G.; D'Ariano, G. M.; Perinotti, P.; Cerf, N.J.

    2005-10-15

    We investigate the problem of cloning a set of states that is invariant under the action of an irreducible group representation. We then characterize the cloners that are extremal in the convex set of group covariant cloning machines, among which one can restrict the search for optimal cloners. For a set of states that is invariant under the discrete Weyl-Heisenberg group, we show that all extremal cloners can be unitarily realized using the so-called double-Bell states, whence providing a general proof of the popular ansatz used in the literature for finding optimal cloners in a variety of settings. Our result can also be generalized to continuous-variable optimal cloning in infinite dimensions, where the covariance group is the customary Weyl-Heisenberg group of displacement000.

  4. MEMS electrostatic influence machines

    NASA Astrophysics Data System (ADS)

    Phu Le, Cuong; Halvorsen, Einar

    2016-11-01

    This paper analyses the possibility of MEMS electrostatic influence machines using electromechanical switches like the historical predecessors did two centuries ago. We find that a generator design relying entirely on standard silicon-on-insulator(SOI) micromachining is conceivable and analyze its performance by simulations. The concept appears preferable over comparable diode circuits due to its higher maximum energy, faster charging and low precharging voltage. A full electromechanical lumped-model including parasitic capacitances of the switches is built to capture the dynamic of the generator. Simulation results show that the output voltage can be exponentially bootstrapped from a very low precharging voltage so that otherwise inadequately small voltage differences or charge imbalances can be made useful.

  5. Anaesthesia Machine: Checklist, Hazards, Scavenging

    PubMed Central

    Goneppanavar, Umesh; Prabhu, Manjunath

    2013-01-01

    From a simple pneumatic device of the early 20th century, the anaesthesia machine has evolved to incorporate various mechanical, electrical and electronic components to be more appropriately called anaesthesia workstation. Modern machines have overcome many drawbacks associated with the older machines. However, addition of several mechanical, electronic and electric components has contributed to recurrence of some of the older problems such as leak or obstruction attributable to newer gadgets and development of newer problems. No single checklist can satisfactorily test the integrity and safety of all existing anaesthesia machines due to their complex nature as well as variations in design among manufacturers. Human factors have contributed to greater complications than machine faults. Therefore, better understanding of the basics of anaesthesia machine and checking each component of the machine for proper functioning prior to use is essential to minimise these hazards. Clear documentation of regular and appropriate servicing of the anaesthesia machine, its components and their satisfactory functioning following servicing and repair is also equally important. Trace anaesthetic gases polluting the theatre atmosphere can have several adverse effects on the health of theatre personnel. Therefore, safe disposal of these gases away from the workplace with efficiently functioning scavenging system is necessary. Other ways of minimising atmospheric pollution such as gas delivery equipment with negligible leaks, low flow anaesthesia, minimal leak around the airway equipment (facemask, tracheal tube, laryngeal mask airway, etc.) more than 15 air changes/hour and total intravenous anaesthesia should also be considered. PMID:24249887

  6. Self-Adjusting Teaching Machines.

    ERIC Educational Resources Information Center

    Dovgyallo, A. M.

    A study was made on the synthesis of teaching machine elements to ensure the stabilization of the chi indicator of the teaching process of each student. At first, a procedure was developed for calculating the chi indicator for the case when the teaching machine predicts the magnitude of this indicator based on probabilities derived from an…

  7. Anaesthesia machine: checklist, hazards, scavenging.

    PubMed

    Goneppanavar, Umesh; Prabhu, Manjunath

    2013-09-01

    From a simple pneumatic device of the early 20(th) century, the anaesthesia machine has evolved to incorporate various mechanical, electrical and electronic components to be more appropriately called anaesthesia workstation. Modern machines have overcome many drawbacks associated with the older machines. However, addition of several mechanical, electronic and electric components has contributed to recurrence of some of the older problems such as leak or obstruction attributable to newer gadgets and development of newer problems. No single checklist can satisfactorily test the integrity and safety of all existing anaesthesia machines due to their complex nature as well as variations in design among manufacturers. Human factors have contributed to greater complications than machine faults. Therefore, better understanding of the basics of anaesthesia machine and checking each component of the machine for proper functioning prior to use is essential to minimise these hazards. Clear documentation of regular and appropriate servicing of the anaesthesia machine, its components and their satisfactory functioning following servicing and repair is also equally important. Trace anaesthetic gases polluting the theatre atmosphere can have several adverse effects on the health of theatre personnel. Therefore, safe disposal of these gases away from the workplace with efficiently functioning scavenging system is necessary. Other ways of minimising atmospheric pollution such as gas delivery equipment with negligible leaks, low flow anaesthesia, minimal leak around the airway equipment (facemask, tracheal tube, laryngeal mask airway, etc.) more than 15 air changes/hour and total intravenous anaesthesia should also be considered.

  8. Two color machining of composites

    SciTech Connect

    Maher, W.

    1996-12-31

    Quality cutting and drilling of 9 composite materials is possible using diode-pumped neodymium lasers. Machining at 1.06 {mu}m is improved by optimizing the pulse format of the diode-pumped neodymium lasers of the Precision Laser Machining (PLM) Consortium. Further improvements are obtained with the PLM lasers operating at 0.53 {mu}m.

  9. The Blindstitch Machine. Module 11.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia. Office of Vocational Education.

    This module on the purpose and use of the blindstitch machine, one in a series on clothing construction for industrial sewing machine operators designed for student self-study, contains three sections. Each section includes the following parts: an introduction, directions, an objective, learning activities, student information, student self-check,…

  10. Robotics: self-reproducing machines.

    PubMed

    Zykov, Victor; Mytilinaios, Efstathios; Adams, Bryant; Lipson, Hod

    2005-05-12

    Self-reproduction is central to biological life for long-term sustainability and evolutionary adaptation. Although these traits would also be desirable in many engineered systems, the principles of self-reproduction have not been exploited in machine design. Here we create simple machines that act as autonomous modular robots and are capable of physical self-reproduction using a set of cubes.

  11. Machine Trades Lab Management Guide.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This manual was developed to guide machine trades instructors and vocational supervisors in sequencing laboratory instruction and controlling the flow of work for a 2-year machine trades training program. The first part of the guide provides information on program management (program description, safety concerns, academic issues, implementation…

  12. Machine Accounting. An Instructor's Guide.

    ERIC Educational Resources Information Center

    Gould, E. Noah, Ed.

    Designed to prepare students to operate the types of accounting machines used in many medium-sized businesses, this instructor's guide presents a full-year high school course in machine accounting covering 120 hours of instruction. An introduction for the instructor suggests how to adapt the guide to present a 60-hour module which would be…

  13. The Machine Scoring of Writing

    ERIC Educational Resources Information Center

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  14. The Machine Intelligence Hex Project

    ERIC Educational Resources Information Center

    Chalup, Stephan K.; Mellor, Drew; Rosamond, Fran

    2005-01-01

    Hex is a challenging strategy board game for two players. To enhance students' progress in acquiring understanding and practical experience with complex machine intelligence and programming concepts we developed the Machine Intelligence Hex (MIHex) project. The associated undergraduate student assignment is about designing and implementing Hex…

  15. Man and Machines: Three Criticisms.

    ERIC Educational Resources Information Center

    Schneider, Edward F.

    As machines have become a more common part of daily life through the passage of time, the idea that the line separating man and machine is slowly fading has become more popular as well. This paper examines three critics of change through their most famous works. One of the most popular views of Mary Shelley's "Frankenstein" is that it is a…

  16. Cleaning of Free Machining Brass

    SciTech Connect

    Shen, T

    2005-12-29

    We have investigated four brightening treatments proposed by two cleaning vendors for cleaning free machining brass. The experimental results showed that none of the proposed brightening treatments passed the swipe test. Thus, we maintain the recommendation of not using the brightening process in the cleaning of free machining brass for NIF application.

  17. Contraction-Only Exercise Machine

    NASA Technical Reports Server (NTRS)

    Doerr, Donald F.; Maples, Arthur B.; Campbell, Craig M.

    1992-01-01

    Standard knee-extension machine modified so subject experiences force only when lifting leg against stack of weights. Exerts little force on leg while being lowered. Hydraulic cylinder and reservoir mounted on frame of exercise machine. Fluid flows freely from cylinder to reservoir during contraction (lifting) but in constricted fashion from reservoir to cylinder during extension (lowering).

  18. Machinability of Stellite 6 hardfacing

    NASA Astrophysics Data System (ADS)

    Benghersallah, M.; Boulanouar, L.; Le Coz, G.; Devillez, A.; Dudzinski, D.

    2010-06-01

    This paper reports some experimental findings concerning the machinability at high cutting speed of nickel-base weld-deposited hardfacings for the manufacture of hot tooling. The forging work involves extreme impacts, forces, stresses and temperatures. Thus, mould dies must be extremely resistant. The aim of the project is to create a rapid prototyping process answering to forging conditions integrating a Stellite 6 hardfacing deposed PTA process. This study talks about the dry machining of the hardfacing, using a two tips machining tool and a high speed milling machine equipped by a power consumption recorder Wattpilote. The aim is to show the machinability of the hardfacing, measuring the power and the tip wear by optical microscope and white light interferometer, using different strategies and cutting conditions.

  19. Improved Methods for Teaching Machine Transcription.

    ERIC Educational Resources Information Center

    Smith, Clara J.

    1980-01-01

    The increased use of machine transcription in business and industry demands that business educators attract and train more highly skilled machine transcriptionists. Realistic production measurement and appropriate vocabulary should be taught to link machine transcription to word processing. (Author)

  20. HUMAN MACHINE COOPERATIVE TELEROBOTICS

    SciTech Connect

    William R. Hamel; Spivey Douglass; Sewoong Kim; Pamela Murray; Yang Shou; Sriram Sridharan; Ge Zhang; Scott Thayer; Rajiv V. Dubey

    2003-06-30

    described as Human Machine Cooperative Telerobotics (HMCTR). The HMCTR combines the telerobot with robotic control techniques to improve the system efficiency and reliability in teleoperation mode. In this topical report, the control strategy, configuration and experimental results of Human Machines Cooperative Telerobotics (HMCTR), which modifies and limits the commands of human operator to follow the predefined constraints in the teleoperation mode, is described. The current implementation is a laboratory-scale system that will be incorporated into an engineering-scale system at the Oak Ridge National Laboratory in the future.

  1. Machine Learning for Medical Imaging.

    PubMed

    Erickson, Bradley J; Korfiatis, Panagiotis; Akkus, Zeynettin; Kline, Timothy L

    2017-01-01

    Machine learning is a technique for recognizing patterns that can be applied to medical images. Although it is a powerful tool that can help in rendering medical diagnoses, it can be misapplied. Machine learning typically begins with the machine learning algorithm system computing the image features that are believed to be of importance in making the prediction or diagnosis of interest. The machine learning algorithm system then identifies the best combination of these image features for classifying the image or computing some metric for the given image region. There are several methods that can be used, each with different strengths and weaknesses. There are open-source versions of most of these machine learning methods that make them easy to try and apply to images. Several metrics for measuring the performance of an algorithm exist; however, one must be aware of the possible associated pitfalls that can result in misleading metrics. More recently, deep learning has started to be used; this method has the benefit that it does not require image feature identification and calculation as a first step; rather, features are identified as part of the learning process. Machine learning has been used in medical imaging and will have a greater influence in the future. Those working in medical imaging must be aware of how machine learning works. (©)RSNA, 2017.

  2. Machine vision for digital microfluidics.

    PubMed

    Shin, Yong-Jun; Lee, Jeong-Bong

    2010-01-01

    Machine vision is widely used in an industrial environment today. It can perform various tasks, such as inspecting and controlling production processes, that may require humanlike intelligence. The importance of imaging technology for biological research or medical diagnosis is greater than ever. For example, fluorescent reporter imaging enables scientists to study the dynamics of gene networks with high spatial and temporal resolution. Such high-throughput imaging is increasingly demanding the use of machine vision for real-time analysis and control. Digital microfluidics is a relatively new technology with expectations of becoming a true lab-on-a-chip platform. Utilizing digital microfluidics, only small amounts of biological samples are required and the experimental procedures can be automatically controlled. There is a strong need for the development of a digital microfluidics system integrated with machine vision for innovative biological research today. In this paper, we show how machine vision can be applied to digital microfluidics by demonstrating two applications: machine vision-based measurement of the kinetics of biomolecular interactions and machine vision-based droplet motion control. It is expected that digital microfluidics-based machine vision system will add intelligence and automation to high-throughput biological imaging in the future.

  3. A Boltzmann machine for the organization of intelligent machines

    NASA Technical Reports Server (NTRS)

    Moed, Michael C.; Saridis, George N.

    1990-01-01

    A three-tier structure consisting of organization, coordination, and execution levels forms the architecture of an intelligent machine using the principle of increasing precision with decreasing intelligence from a hierarchically intelligent control. This system has been formulated as a probabilistic model, where uncertainty and imprecision can be expressed in terms of entropies. The optimal strategy for decision planning and task execution can be found by minimizing the total entropy in the system. The focus is on the design of the organization level as a Boltzmann machine. Since this level is responsible for planning the actions of the machine, the Boltzmann machine is reformulated to use entropy as the cost function to be minimized. Simulated annealing, expanding subinterval random search, and the genetic algorithm are presented as search techniques to efficiently find the desired action sequence and illustrated with numerical examples.

  4. Slide system for machine tools

    DOEpatents

    Douglass, Spivey S.; Green, Walter L.

    1982-01-01

    The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

  5. Slide system for machine tools

    DOEpatents

    Douglass, S.S.; Green, W.L.

    1980-06-12

    The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

  6. Gloved Human-Machine Interface

    NASA Technical Reports Server (NTRS)

    Adams, Richard (Inventor); Olowin, Aaron (Inventor); Hannaford, Blake (Inventor)

    2015-01-01

    Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to: tracking movement of a gloved hand of a human; interpreting a gloved finger movement of the human; and/or in response to interpreting the gloved finger movement, providing feedback to the human.

  7. Virtual Machine Language

    NASA Technical Reports Server (NTRS)

    Grasso, Christopher; Page, Dennis; O'Reilly, Taifun; Fteichert, Ralph; Lock, Patricia; Lin, Imin; Naviaux, Keith; Sisino, John

    2005-01-01

    Virtual Machine Language (VML) is a mission-independent, reusable software system for programming for spacecraft operations. Features of VML include a rich set of data types, named functions, parameters, IF and WHILE control structures, polymorphism, and on-the-fly creation of spacecraft commands from calculated values. Spacecraft functions can be abstracted into named blocks that reside in files aboard the spacecraft. These named blocks accept parameters and execute in a repeatable fashion. The sizes of uplink products are minimized by the ability to call blocks that implement most of the command steps. This block approach also enables some autonomous operations aboard the spacecraft, such as aerobraking, telemetry conditional monitoring, and anomaly response, without developing autonomous flight software. Operators on the ground write blocks and command sequences in a concise, high-level, human-readable programming language (also called VML ). A compiler translates the human-readable blocks and command sequences into binary files (the operations products). The flight portion of VML interprets the uplinked binary files. The ground subsystem of VML also includes an interactive sequence- execution tool hosted on workstations, which runs sequences at several thousand times real-time speed, affords debugging, and generates reports. This tool enables iterative development of blocks and sequences within times of the order of seconds.

  8. Solid waste comminution machine

    SciTech Connect

    Barclay, R.L.

    1986-08-26

    A solid waste comminution machine is described of the type having two sets of interleaving wheels, including a lower set and an upper set of wheel members. Each set includes a pair of shafts on which the wheel members are mounted, the pairs of shafts mounted on upright, mutually facing, movable arms. The improvement consists of: the upper set of wheel members having ripping and shearing tools attached to the circumferential periphery of the wheel members, the pair of shafts associated with the upper set of wheel members mounted on the movable arms, the lower set of wheel members mounted on a pair of fixed, parallel shafts, the shafts supported at one end of the arms with the lower set of wheel members interleaving in a material shearing relation. The shafts form a fixed pivot axis for the arms, the arms having fixed lengths with inward and outward ends, the outward ends extending beyond the shafts associated with the upper set of wheels thereby forming leverage regions, and hydraulic piston means having fixed ends and free ends, the free ends connected to the leverage regions for bringing the arms toward each other to a point at which the upper set of wheels mesh with sufficient force to enable ripping of material between the upper set of wheels.

  9. Lubrication of Machine Elements

    NASA Technical Reports Server (NTRS)

    Hamrock, B. J.

    1984-01-01

    The understanding of hydrodynamic lubrication began with the classical experiments of Tower and Petrov. Reynolds used a reduced form of the Navier-Stokes equations and the continuity equation to generate a second order differential equation for the pressure in the narrow, converging gap of a bearing contact. Such a pressure enables a load to be transmitted between the surfaces with very low friction since the surfaces are completely separated by a film of fluid. In such a situation it is the physical properties of the lubricant, notably the dynamic viscosity, that dictate the behavior of the contact. The understanding of boundary lubrication is normally attributed to Hardy and Doubleday. In boundary lubrication it is the physical and chemical properties of thin films of molecular proportions and the surfaces to which they are attached that determine contact behavior. The lubricant viscosity is not an influential parameter. Research is devoted to a better understanding and more precise definition of other lubrication regimes between these extremes. One such regime, elastohydrodynamic lubrication, occurs in nonconformal contacts, where the pressures are high and the bearing surfaces deform elastically. In this situation the viscosity of the lubricant may raise considerably, and this further assists the formation of an effective fluid film. The science of these three lubrication regimes (hydrodynamic, elastohydrodynamic, and boundary) are described and the manner in which this science is used in the design of machine elements is examined.

  10. Video time encoding machines.

    PubMed

    Lazar, Aurel A; Pnevmatikakis, Eftychios A

    2011-03-01

    We investigate architectures for time encoding and time decoding of visual stimuli such as natural and synthetic video streams (movies, animation). The architecture for time encoding is akin to models of the early visual system. It consists of a bank of filters in cascade with single-input multi-output neural circuits. Neuron firing is based on either a threshold-and-fire or an integrate-and-fire spiking mechanism with feedback. We show that analog information is represented by the neural circuits as projections on a set of band-limited functions determined by the spike sequence. Under Nyquist-type and frame conditions, the encoded signal can be recovered from these projections with arbitrary precision. For the video time encoding machine architecture, we demonstrate that band-limited video streams of finite energy can be faithfully recovered from the spike trains and provide a stable algorithm for perfect recovery. The key condition for recovery calls for the number of neurons in the population to be above a threshold value.

  11. Size reduction machine

    SciTech Connect

    Fricke, V.

    1999-12-15

    The Size Reduction Machine (SRM) is a mobile platform capable of shearing various shapes and types of metal components at a variety of elevations. This shearing activity can be performed without direct physical movement and placement of the shear head by the operator. The base unit is manually moved and roughly aligned to each cut location. The base contains the electronics: hydraulic pumps, servos, and actuators needed to move the shear-positioning arm. The movable arm allows the shear head to have six axes of movement and to cut to within 4 inches of a wall surface. The unit has a slick electrostatic capture coating to assist in external decontamination. Internal contamination of the unit is controlled by a high-efficiency particulate air (HEPA) filter on the cooling inlet fan. The unit is compact enough to access areas through a 36-inch standard door opening. This paper is an Innovative Technology Summary Report designed to provide potential users with the information they need to quickly determine if a technology would apply to a particular environmental management problem. They also are designed for readers who may recommend that a technology be considered by prospective users.

  12. Quantum-Enhanced Machine Learning.

    PubMed

    Dunjko, Vedran; Taylor, Jacob M; Briegel, Hans J

    2016-09-23

    The emerging field of quantum machine learning has the potential to substantially aid in the problems and scope of artificial intelligence. This is only enhanced by recent successes in the field of classical machine learning. In this work we propose an approach for the systematic treatment of machine learning, from the perspective of quantum information. Our approach is general and covers all three main branches of machine learning: supervised, unsupervised, and reinforcement learning. While quantum improvements in supervised and unsupervised learning have been reported, reinforcement learning has received much less attention. Within our approach, we tackle the problem of quantum enhancements in reinforcement learning as well, and propose a systematic scheme for providing improvements. As an example, we show that quadratic improvements in learning efficiency, and exponential improvements in performance over limited time periods, can be obtained for a broad class of learning problems.

  13. Quantum-Enhanced Machine Learning

    NASA Astrophysics Data System (ADS)

    Dunjko, Vedran; Taylor, Jacob M.; Briegel, Hans J.

    2016-09-01

    The emerging field of quantum machine learning has the potential to substantially aid in the problems and scope of artificial intelligence. This is only enhanced by recent successes in the field of classical machine learning. In this work we propose an approach for the systematic treatment of machine learning, from the perspective of quantum information. Our approach is general and covers all three main branches of machine learning: supervised, unsupervised, and reinforcement learning. While quantum improvements in supervised and unsupervised learning have been reported, reinforcement learning has received much less attention. Within our approach, we tackle the problem of quantum enhancements in reinforcement learning as well, and propose a systematic scheme for providing improvements. As an example, we show that quadratic improvements in learning efficiency, and exponential improvements in performance over limited time periods, can be obtained for a broad class of learning problems.

  14. Diamond turning machine controller implementation

    SciTech Connect

    Garrard, K.P.; Taylor, L.W.; Knight, B.F.; Fornaro, R.J.

    1988-12-01

    The standard controller for a Pnuemo ASG 2500 Diamond Turning Machine, an Allen Bradley 8200, has been replaced with a custom high-performance design. This controller consists of four major components. Axis position feedback information is provided by a Zygo Axiom 2/20 laser interferometer with 0.1 micro-inch resolution. Hardware interface logic couples the computers digital and analog I/O channels to the diamond turning machine`s analog motor controllers, the laser interferometer, and other machine status and control information. It also provides front panel switches for operator override of the computer controller and implement the emergency stop sequence. The remaining two components, the control computer hardware and software, are discussed in detail below.

  15. Z Machine at Sandia Labs

    SciTech Connect

    2007-10-17

    Sandia Labs' Z machine is the largest laboratory source of x-rays in the world. For the few nanoseconds of a Z Machine test, its electrical output equals the output of 50x the electrical generating stations of all the power plants on earth. The Z Machine complex encompasses an area roughly the size of a major college basketball arena. Originally created to validate nuclear weapons models, the Z Machine is also considered a "dark horse" in the race for viable fusion energy production. After the famous "arcs and sparks" photo of Z (a photo no longer possible after its refurbishment), this is a fast-motion video of workers completing Z's recent refurbishment.

  16. Biosleeve Human-Machine Interface

    NASA Technical Reports Server (NTRS)

    Assad, Christopher (Inventor)

    2016-01-01

    Systems and methods for sensing human muscle action and gestures in order to control machines or robotic devices are disclosed. One exemplary system employs a tight fitting sleeve worn on a user arm and including a plurality of electromyography (EMG) sensors and at least one inertial measurement unit (IMU). Power, signal processing, and communications electronics may be built into the sleeve and control data may be transmitted wirelessly to the controlled machine or robotic device.

  17. Building and simulating protein machines

    NASA Astrophysics Data System (ADS)

    Katebi, Ataur Rahim

    Glycolysis is a central metabolic pathway, present in almost all organisms, that produces energy. The pathway has been extensively investigated by biochemists. There is a significant body of structural and biochemical information about this pathway. The complete pathway is a ten step process. At each step, a specific chemical reaction is catalyzed by a specific enzyme. Fructose bisphosphate aldolase (FBA) and triosephosphate isomerase (TIM) catalyze the fourth and the fifth steps on the pathway. This thesis investigates the possible substrate transfer mechanism between FBA and TIM. FBA cleaves its substrate, the six-carbon fructose-1,6-bisphosphate (FBP), into two three-carbon products -- glyceraldehydes 3-phosphate (GAP) and dihydroxy acetone phosphate (DHAP). One component of these two products, DHAP, is the substrate for TIM and the other component GAP goes directly to GAPDH, the subsequent enzyme on the pathway. TIM converts DHAP to GAP and delivers the product to GAPDH. I employ Elastic Network Models (ENM) to investigate the mechanistic and dynamic aspects of the functionality of FBA and TIM enzymes -- (1) the effects of the oligomerization of these two enzymes on their functional dynamics and the coordination of the individual protein's structural components along the functional region; and (2) the mechanistic synchrony of these two protein machines that may enable them to operate in a coordinated fashion as a conjugate machine -- transferring the product from FBA as substrate to TIM. A macromolecular machine comprised of FBA and TIM will facilitate the substrate catalysis mechanism and the product flow between FBA and TIM. Such a machine could be used as a functional unit in building a larger a machine for the structural modeling of the whole glycolysis pathway. Building such machines for the glycolysis pathway may reveal the interplay of the enzymes as a complete machine. Also the methods and insights developed from the efforts to build such large machines

  18. Machine Gun Liner Bond Strength

    DTIC Science & Technology

    2007-08-01

    investigation does not constitute a complete analysis of liner failures in the M2 machine gun. The fact that two different liner-failure modes were...An order-of-magnitude estimate can be made of the bond strength in this case using a standard elastic analysis and some reasonable assumptions... analysis of the forces on the machine gun bullet, it was found that the measured bond strength was adequate to resist the reaction forces produced when

  19. Adaptive machine vision. Annual report

    SciTech Connect

    Stoner, W.W.; Brill, M.H.; Bergeron, D.W.

    1988-03-08

    The mission of the Strategic Defense Initiative is to develop defenses against threatening ballistic missiles. There are four distinct phases to the SDI defense; boost, post-boost, midcourse and terminal. In each of these phases, one or more machine-vision functions are required, such as pattern recognition, stereo image fusion, clutter rejection and discrimination. The SDI missions of coarse track, stereo track and discrimination are examined here from the point of view of a machine-vision system.

  20. Model-based machine learning.

    PubMed

    Bishop, Christopher M

    2013-02-13

    Several decades of research in the field of machine learning have resulted in a multitude of different algorithms for solving a broad range of problems. To tackle a new application, a researcher typically tries to map their problem onto one of these existing methods, often influenced by their familiarity with specific algorithms and by the availability of corresponding software implementations. In this study, we describe an alternative methodology for applying machine learning, in which a bespoke solution is formulated for each new application. The solution is expressed through a compact modelling language, and the corresponding custom machine learning code is then generated automatically. This model-based approach offers several major advantages, including the opportunity to create highly tailored models for specific scenarios, as well as rapid prototyping and comparison of a range of alternative models. Furthermore, newcomers to the field of machine learning do not have to learn about the huge range of traditional methods, but instead can focus their attention on understanding a single modelling environment. In this study, we show how probabilistic graphical models, coupled with efficient inference algorithms, provide a very flexible foundation for model-based machine learning, and we outline a large-scale commercial application of this framework involving tens of millions of users. We also describe the concept of probabilistic programming as a powerful software environment for model-based machine learning, and we discuss a specific probabilistic programming language called Infer.NET, which has been widely used in practical applications.

  1. Model-based machine learning

    PubMed Central

    Bishop, Christopher M.

    2013-01-01

    Several decades of research in the field of machine learning have resulted in a multitude of different algorithms for solving a broad range of problems. To tackle a new application, a researcher typically tries to map their problem onto one of these existing methods, often influenced by their familiarity with specific algorithms and by the availability of corresponding software implementations. In this study, we describe an alternative methodology for applying machine learning, in which a bespoke solution is formulated for each new application. The solution is expressed through a compact modelling language, and the corresponding custom machine learning code is then generated automatically. This model-based approach offers several major advantages, including the opportunity to create highly tailored models for specific scenarios, as well as rapid prototyping and comparison of a range of alternative models. Furthermore, newcomers to the field of machine learning do not have to learn about the huge range of traditional methods, but instead can focus their attention on understanding a single modelling environment. In this study, we show how probabilistic graphical models, coupled with efficient inference algorithms, provide a very flexible foundation for model-based machine learning, and we outline a large-scale commercial application of this framework involving tens of millions of users. We also describe the concept of probabilistic programming as a powerful software environment for model-based machine learning, and we discuss a specific probabilistic programming language called Infer.NET, which has been widely used in practical applications. PMID:23277612

  2. 15 CFR 5.5 - Vending machines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a...

  3. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  4. 15 CFR 5.5 - Vending machines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a...

  5. 15 CFR 700.31 - Metalworking machines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Metalworking machines. 700.31 Section... Metalworking machines. (a) “Metalworking machines” include power driven, manual or automatic, metal cutting and metal forming machines and complete machines not supported in the hands of an operator when in...

  6. 15 CFR 5.5 - Vending machines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a...

  7. 15 CFR 700.31 - Metalworking machines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Metalworking machines. 700.31 Section... Metalworking machines. (a) “Metalworking machines” include power driven, manual or automatic, metal cutting and metal forming machines and complete machines not supported in the hands of an operator when in...

  8. 15 CFR 5.5 - Vending machines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a...

  9. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  10. 15 CFR 700.31 - Metalworking machines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Metalworking machines. 700.31 Section... Metalworking machines. (a) “Metalworking machines” include power driven, manual or automatic, metal cutting and metal forming machines and complete machines not supported in the hands of an operator when in...

  11. 15 CFR 5.5 - Vending machines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Vending machines. 5.5 Section 5.5... machines. (a) The income from any vending machines which are located within reasonable proximity to and are... shall be assigned to the operator of such stand. (b) If a vending machine vends articles of a...

  12. Web Mining: Machine Learning for Web Applications.

    ERIC Educational Resources Information Center

    Chen, Hsinchun; Chau, Michael

    2004-01-01

    Presents an overview of machine learning research and reviews methods used for evaluating machine learning systems. Ways that machine-learning algorithms were used in traditional information retrieval systems in the "pre-Web" era are described, and the field of Web mining and how machine learning has been used in different Web mining…

  13. 15 CFR 700.31 - Metalworking machines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., power driven Machining centers and way-type machines Manual presses Mechanical presses, power driven... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Metalworking machines. 700.31 Section... Metalworking machines. (a) “Metalworking machines” include power driven, manual or automatic, metal cutting...

  14. 15 CFR 700.31 - Metalworking machines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., power driven Machining centers and way-type machines Manual presses Mechanical presses, power driven... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Metalworking machines. 700.31 Section... Metalworking machines. (a) “Metalworking machines” include power driven, manual or automatic, metal cutting...

  15. Compensating for Shrinkage in Machined Ceramics

    NASA Technical Reports Server (NTRS)

    Aguilar, L.; Fitchett, B. T.

    1986-01-01

    Technique insures machined ceramics shrink to correct dimensions after baked in kiln. New method automatically compensates during machining for shrinkage later, when part baked. Applicable to numerically controlled machines that include provision to adjust for variations in cuttingtool size, but do not provide for automatic verification of dimensions of machined parts.

  16. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  17. Dry Machining Process of Milling Machine using Axiomatic Green Methodology

    NASA Astrophysics Data System (ADS)

    Puspita Andriani, Gita; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Most of companies know that there are strategies to become green industry, and they realize that green efforts have impacts on product quality and cost. Axiomatic Green Methodology models the relationship between green, quality, and cost. This methodology starts with determining the green improvement objective and then continues with mapping the functional, economic, and green requirements. From the mapping, variables which affect the requirements are identified. Afterwards, the effect of each variable is determined by performing experiments and regression modelling. In this research, axiomatic green methodology was implemented to dry machining of milling machine in order to reduce the amount of coolant. Dry machining will be feasible if it is not worse than the minimum required quality. As a result, dry machining is feasible without producing any defect. The proposed machining parameter is to reduce the coolant flow rate from 6.882 ml/minute to 0 ml/minute, set the depth of cut at 1.2 mm, spindle rotation speed at 500 rpm, and feed rate at 128 mm/minute. This solution is also resulted in reduction of cost for 200.48 rupiahs for each process.

  18. Analysis and design of asymmetrical reluctance machine

    NASA Astrophysics Data System (ADS)

    Harianto, Cahya A.

    Over the past few decades the induction machine has been chosen for many applications due to its structural simplicity and low manufacturing cost. However, modest torque density and control challenges have motivated researchers to find alternative machines. The permanent magnet synchronous machine has been viewed as one of the alternatives because it features higher torque density for a given loss than the induction machine. However, the assembly and permanent magnet material cost, along with safety under fault conditions, have been concerns for this class of machine. An alternative machine type, namely the asymmetrical reluctance machine, is proposed in this work. Since the proposed machine is of the reluctance machine type, it possesses desirable feature, such as near absence of rotor losses, low assembly cost, low no-load rotational losses, modest torque ripple, and rather benign fault conditions. Through theoretical analysis performed herein, it is shown that this machine has a higher torque density for a given loss than typical reluctance machines, although not as high as the permanent magnet machines. Thus, the asymmetrical reluctance machine is a viable and advantageous machine alternative where the use of permanent magnet machines are undesirable.

  19. Risk estimation using probability machines

    PubMed Central

    2014-01-01

    Background Logistic regression has been the de facto, and often the only, model used in the description and analysis of relationships between a binary outcome and observed features. It is widely used to obtain the conditional probabilities of the outcome given predictors, as well as predictor effect size estimates using conditional odds ratios. Results We show how statistical learning machines for binary outcomes, provably consistent for the nonparametric regression problem, can be used to provide both consistent conditional probability estimation and conditional effect size estimates. Effect size estimates from learning machines leverage our understanding of counterfactual arguments central to the interpretation of such estimates. We show that, if the data generating model is logistic, we can recover accurate probability predictions and effect size estimates with nearly the same efficiency as a correct logistic model, both for main effects and interactions. We also propose a method using learning machines to scan for possible interaction effects quickly and efficiently. Simulations using random forest probability machines are presented. Conclusions The models we propose make no assumptions about the data structure, and capture the patterns in the data by just specifying the predictors involved and not any particular model structure. So they do not run the same risks of model mis-specification and the resultant estimation biases as a logistic model. This methodology, which we call a “risk machine”, will share properties from the statistical machine that it is derived from. PMID:24581306

  20. Reusable State Machine Code Generator

    NASA Astrophysics Data System (ADS)

    Hoffstadt, A. A.; Reyes, C.; Sommer, H.; Andolfato, L.

    2010-12-01

    The State Machine model is frequently used to represent the behaviour of a system, allowing one to express and execute this behaviour in a deterministic way. A graphical representation such as a UML State Chart diagram tames the complexity of the system, thus facilitating changes to the model and communication between developers and domain experts. We present a reusable state machine code generator, developed by the Universidad Técnica Federico Santa María and the European Southern Observatory. The generator itself is based on the open source project architecture, and uses UML State Chart models as input. This allows for a modular design and a clean separation between generator and generated code. The generated state machine code has well-defined interfaces that are independent of the implementation artefacts such as the middle-ware. This allows using the generator in the substantially different observatory software of the Atacama Large Millimeter Array and the ESO Very Large Telescope. A project-specific mapping layer for event and transition notification connects the state machine code to its environment, which can be the Common Software of these projects, or any other project. This approach even allows to automatically create tests for a generated state machine, using techniques from software testing, such as path-coverage.

  1. Game-powered machine learning.

    PubMed

    Barrington, Luke; Turnbull, Douglas; Lanckriet, Gert

    2012-04-24

    Searching for relevant content in a massive amount of multimedia information is facilitated by accurately annotating each image, video, or song with a large number of relevant semantic keywords, or tags. We introduce game-powered machine learning, an integrated approach to annotating multimedia content that combines the effectiveness of human computation, through online games, with the scalability of machine learning. We investigate this framework for labeling music. First, a socially-oriented music annotation game called Herd It collects reliable music annotations based on the "wisdom of the crowds." Second, these annotated examples are used to train a supervised machine learning system. Third, the machine learning system actively directs the annotation games to collect new data that will most benefit future model iterations. Once trained, the system can automatically annotate a corpus of music much larger than what could be labeled using human computation alone. Automatically annotated songs can be retrieved based on their semantic relevance to text-based queries (e.g., "funky jazz with saxophone," "spooky electronica," etc.). Based on the results presented in this paper, we find that actively coupling annotation games with machine learning provides a reliable and scalable approach to making searchable massive amounts of multimedia data.

  2. Game-powered machine learning

    PubMed Central

    Barrington, Luke; Turnbull, Douglas; Lanckriet, Gert

    2012-01-01

    Searching for relevant content in a massive amount of multimedia information is facilitated by accurately annotating each image, video, or song with a large number of relevant semantic keywords, or tags. We introduce game-powered machine learning, an integrated approach to annotating multimedia content that combines the effectiveness of human computation, through online games, with the scalability of machine learning. We investigate this framework for labeling music. First, a socially-oriented music annotation game called Herd It collects reliable music annotations based on the “wisdom of the crowds.” Second, these annotated examples are used to train a supervised machine learning system. Third, the machine learning system actively directs the annotation games to collect new data that will most benefit future model iterations. Once trained, the system can automatically annotate a corpus of music much larger than what could be labeled using human computation alone. Automatically annotated songs can be retrieved based on their semantic relevance to text-based queries (e.g., “funky jazz with saxophone,” “spooky electronica,” etc.). Based on the results presented in this paper, we find that actively coupling annotation games with machine learning provides a reliable and scalable approach to making searchable massive amounts of multimedia data. PMID:22460786

  3. Mechanical design of walking machines.

    PubMed

    Arikawa, Keisuke; Hirose, Shigeo

    2007-01-15

    The performance of existing actuators, such as electric motors, is very limited, be it power-weight ratio or energy efficiency. In this paper, we discuss the method to design a practical walking machine under this severe constraint with focus on two concepts, the gravitationally decoupled actuation (GDA) and the coupled drive. The GDA decouples the driving system against the gravitational field to suppress generation of negative power and improve energy efficiency. On the other hand, the coupled drive couples the driving system to distribute the output power equally among actuators and maximize the utilization of installed actuator power. First, we depict the GDA and coupled drive in detail. Then, we present actual machines, TITAN-III and VIII, quadruped walking machines designed on the basis of the GDA, and NINJA-I and II, quadruped wall walking machines designed on the basis of the coupled drive. Finally, we discuss walking machines that travel on three-dimensional terrain (3D terrain), which includes the ground, walls and ceiling. Then, we demonstrate with computer simulation that we can selectively leverage GDA and coupled drive by walking posture control.

  4. Energy landscapes for machine learning.

    PubMed

    Ballard, Andrew J; Das, Ritankar; Martiniani, Stefano; Mehta, Dhagash; Sagun, Levent; Stevenson, Jacob D; Wales, David J

    2017-04-03

    Machine learning techniques are being increasingly used as flexible non-linear fitting and prediction tools in the physical sciences. Fitting functions that exhibit multiple solutions as local minima can be analysed in terms of the corresponding machine learning landscape. Methods to explore and visualise molecular potential energy landscapes can be applied to these machine learning landscapes to gain new insight into the solution space involved in training and the nature of the corresponding predictions. In particular, we can define quantities analogous to molecular structure, thermodynamics, and kinetics, and relate these emergent properties to the structure of the underlying landscape. This Perspective aims to describe these analogies with examples from recent applications, and suggest avenues for new interdisciplinary research.

  5. Minimal universal quantum heat machine.

    PubMed

    Gelbwaser-Klimovsky, D; Alicki, R; Kurizki, G

    2013-01-01

    In traditional thermodynamics the Carnot cycle yields the ideal performance bound of heat engines and refrigerators. We propose and analyze a minimal model of a heat machine that can play a similar role in quantum regimes. The minimal model consists of a single two-level system with periodically modulated energy splitting that is permanently, weakly, coupled to two spectrally separated heat baths at different temperatures. The equation of motion allows us to compute the stationary power and heat currents in the machine consistent with the second law of thermodynamics. This dual-purpose machine can act as either an engine or a refrigerator (heat pump) depending on the modulation rate. In both modes of operation, the maximal Carnot efficiency is reached at zero power. We study the conditions for finite-time optimal performance for several variants of the model. Possible realizations of the model are discussed.

  6. Aerosols generated during beryllium machining.

    PubMed

    Martyny, J W; Hoover, M D; Mroz, M M; Ellis, K; Maier, L A; Sheff, K L; Newman, L S

    2000-01-01

    Some beryllium processes, especially machining, are associated with an increased risk of beryllium sensitization and disease. Little is known about exposure characteristics contributing to risk, such as particle size. This study examined the characteristics of beryllium machining exposures under actual working conditions. Stationary samples, using eight-stage Lovelace Multijet Cascade Impactors, were taken at the process point of operation and at the closest point that the worker would routinely approach. Paired samples were collected at the operator's breathing zone by using a Marple Personal Cascade Impactor and a 35-mm closed-faced cassette. More than 50% of the beryllium machining particles in the breathing zone were less than 10 microns in aerodynamic diameter. This small particle size may result in beryllium deposition into the deepest portion of the lung and may explain elevated rates of sensitization among beryllium machinists.

  7. Biological and biomimetic molecular machines.

    PubMed

    Huang, Tony J; Juluri, Bala K

    2008-02-01

    The evolution of life facilitates the creation of biological molecular machines. In these so-called 'nanomachines,' nature elegantly shows that when precisely organized and assembled, simple molecular mechanical components can link motions efficiently from the nanometer scale to the macroscopic world, and achieve complex functions such as powering skeletal muscles, synthesizing ATP and producing DNA/RNA. Inspired by nature, researchers are creating artifical molecular machines with tailored structures and properties, with the aim of realizing man-made active nanosystems that operate with the same efficiency and complexity as biological nanomachines. It is anticipated that in the not-too-distant future, unique applications of biological and biomimetic molecular machines will emerge in areas such as biochemical instrumentation and nanomedicine.

  8. Alpha Channeling in Mirror Machines

    SciTech Connect

    Fisch N.J.

    2005-10-19

    Because of their engineering simplicity, high-β, and steady-state operation, mirror machines and related open-trap machines such as gas dynamic traps, are an attractive concept for achieving controlled nuclear fusion. In these open-trap machines, the confinement occurs by means of magnetic mirroring, without the magnetic field lines closing upon themselves within the region of particle confinement. Unfortunately, these concepts have not achieved to date very spectacular laboratory results, and their reactor prospects are dimmed by the prospect of a low Q-factor, the ratio of fusion power produced to auxiliary power. Nonetheless, because of its engineering promise, over the years numerous improvements have been proposed to enhance the reactor prospects of mirror fusion, such as tandem designs, end-plugging, and electric potential barriers.

  9. Machine learning methods in chemoinformatics

    PubMed Central

    Mitchell, John B O

    2014-01-01

    Machine learning algorithms are generally developed in computer science or adjacent disciplines and find their way into chemical modeling by a process of diffusion. Though particular machine learning methods are popular in chemoinformatics and quantitative structure–activity relationships (QSAR), many others exist in the technical literature. This discussion is methods-based and focused on some algorithms that chemoinformatics researchers frequently use. It makes no claim to be exhaustive. We concentrate on methods for supervised learning, predicting the unknown property values of a test set of instances, usually molecules, based on the known values for a training set. Particularly relevant approaches include Artificial Neural Networks, Random Forest, Support Vector Machine, k-Nearest Neighbors and naïve Bayes classifiers. WIREs Comput Mol Sci 2014, 4:468–481. How to cite this article: WIREs Comput Mol Sci 2014, 4:468–481. doi:10.1002/wcms.1183 PMID:25285160

  10. Dry machinability of aluminum alloys.

    SciTech Connect

    Shareef, I.; Natarajan, M.; Ajayi, O. O.; Energy Technology; Department of IMET

    2005-01-01

    Adverse effects of the use of cutting fluids and environmental concerns with regard to cutting fluid disposability is compelling industry to adopt Dry or near Dry Machining, with the aim of eliminating or significantly reducing the use of metal working fluids. Pending EPA regulations on metal cutting, dry machining is becoming a hot topic of research and investigation both in industry and federal research labs. Although the need for dry machining may be apparent, most of the manufacturers still consider dry machining to be impractical and even if possible, very expensive. This perception is mainly due to lack of appropriate cutting tools that can withstand intense heat and Built-up-Edge (BUE) formation during dry machining. The challenge of heat dissipation without coolant requires a completely different approach to tooling. Special tooling utilizing high-performance multi-layer, multi-component, heat resisting, low friction coatings could be a plausible answer to the challenge of dry machining. In pursuit of this goal Argonne National Labs has introduced Nano-crystalline near frictionless carbon (NFC) diamond like coatings (DLC), while industrial efforts have led to the introduction of composite coatings such as titanium aluminum nitride (TiAlN), tungsten carbide/carbon (WC/C) and others. Although, these coatings are considered to be very promising, they have not been tested either from tribological or from dry machining applications point of view. As such a research program in partnership with federal labs and industrial sponsors has started with the goal of exploring the feasibility of dry machining using the newly developed coatings such as Near Frictionless Carbon Coatings (NFC), Titanium Aluminum Nitride (TiAlN), and multi-layer multicomponent nano coatings such as TiAlCrYN and TiAlN/YN. Although various coatings are under investigation as part of the overall dry machinability program, this extended abstract deals with a systematic investigation of dry

  11. Information geometry of Boltzmann machines.

    PubMed

    Amari, S; Kurata, K; Nagaoka, H

    1992-01-01

    A Boltzmann machine is a network of stochastic neurons. The set of all the Boltzmann machines with a fixed topology forms a geometric manifold of high dimension, where modifiable synaptic weights of connections play the role of a coordinate system to specify networks. A learning trajectory, for example, is a curve in this manifold. It is important to study the geometry of the neural manifold, rather than the behavior of a single network, in order to know the capabilities and limitations of neural networks of a fixed topology. Using the new theory of information geometry, a natural invariant Riemannian metric and a dual pair of affine connections on the Boltzmann neural network manifold are established. The meaning of geometrical structures is elucidated from the stochastic and the statistical point of view. This leads to a natural modification of the Boltzmann machine learning rule.

  12. Cooling system for rotating machine

    DOEpatents

    Gerstler, William Dwight; El-Refaie, Ayman Mohamed Fawzi; Lokhandwalla, Murtuza; Alexander, James Pellegrino; Quirion, Owen Scott; Palafox, Pepe; Shen, Xiaochun; Salasoo, Lembit

    2011-08-09

    An electrical machine comprising a rotor is presented. The electrical machine includes the rotor disposed on a rotatable shaft and defining a plurality of radial protrusions extending from the shaft up to a periphery of the rotor. The radial protrusions having cavities define a fluid path. A stationary shaft is disposed concentrically within the rotatable shaft wherein an annular space is formed between the stationary and rotatable shaft. A plurality of magnetic segments is disposed on the radial protrusions and the fluid path from within the stationary shaft into the annular space and extending through the cavities within the radial protrusions.

  13. Thermoacoustic simulator for regenerative machines

    NASA Astrophysics Data System (ADS)

    Luo, E.; Wu, J.; Yang, J.; Xiao, J.

    2002-05-01

    Linear thermoacoustic theory is a powerful tool to understand the working mechanism of many regenerative machines. Based on the theory, the authors have developed a computer code "Thermoacoustic Simulator" for analyzing and designing different regenerative cryocoolers including String refrigerators, Stirling and G-M types of pulse tube refrigerators and G-M cryocoolers. Also, standing-wave and traveling-wave thermoacoustic machines can be simulated, too. This paper will present the philosophy of the "Thermoacoustic Simulator" and some demonstrations of simulation for different types of cryocoolers and thermoacoustic engines.

  14. Machine learning phases of matter

    NASA Astrophysics Data System (ADS)

    Carrasquilla, Juan; Stoudenmire, Miles; Melko, Roger

    We show how the technology that allows automatic teller machines read hand-written digits in cheques can be used to encode and recognize phases of matter and phase transitions in many-body systems. In particular, we analyze the (quasi-)order-disorder transitions in the classical Ising and XY models. Furthermore, we successfully use machine learning to study classical Z2 gauge theories that have important technological application in the coming wave of quantum information technologies and whose phase transitions have no conventional order parameter.

  15. Axial gap rotating electrical machine

    DOEpatents

    None

    2016-02-23

    Direct drive rotating electrical machines with axial air gaps are disclosed. In these machines, a rotor ring and stator ring define an axial air gap between them. Sets of gap-maintaining rolling supports bear between the rotor ring and the stator ring at their peripheries to maintain the axial air gap. Also disclosed are wind turbines using these generators, and structures and methods for mounting direct drive rotating electrical generators to the hubs of wind turbines. In particular, the rotor ring of the generator may be carried directly by the hub of a wind turbine to rotate relative to a shaft without being mounted directly to the shaft.

  16. Magnet management in electric machines

    DOEpatents

    Reddy, Patel Bhageerath; El-Refaie, Ayman Mohamed Fawzi; Huh, Kum Kang

    2017-03-21

    A magnet management method of controlling a ferrite-type permanent magnet electrical machine includes receiving and/or estimating the temperature permanent magnets; determining if that temperature is below a predetermined temperature; and if so, then: selectively heating the magnets in order to prevent demagnetization and/or derating the machine. A similar method provides for controlling magnetization level by analyzing flux or magnetization level. Controllers that employ various methods are disclosed. The present invention has been described in terms of specific embodiment(s), and it is recognized that equivalents, alternatives, and modifications, aside from those expressly stated, are possible and within the scope of the appending claims.

  17. Machine translation project alternatives analysis

    NASA Technical Reports Server (NTRS)

    Bajis, Catherine J.; Bedford, Denise A. D.

    1993-01-01

    The Machine Translation Project consists of several components, two of which, the Project Plan and the Requirements Analysis, have already been delivered. The Project Plan details the overall rationale, objectives and time-table for the project as a whole. The Requirements Analysis compares a number of available machine translation systems, their capabilities, possible configurations, and costs. The Alternatives Analysis has resulted in a number of conclusions and recommendations to the NASA STI program concerning the acquisition of specific MT systems and related hardware and software.

  18. Investigation of Surfaces after Non Conventional Machining

    NASA Astrophysics Data System (ADS)

    Micietova, Anna; Neslusan, Miroslav; Cillikova, Maria

    2016-12-01

    This paper deals with analysis of surface integrity of steel after electro discharge machining (EDM), water jet machining, (WJM) laser beam machining (LBM) and plasma beam machining (PBM). The paper discusses surface integrity expressed in surface roughness, sample precision expressed in perpendicularity deviation as well as stress state. This study also demonstrates influence of the various non-conventional methods on structure transformations and reports about sensitivity of the different non-conventional methods of machining with regard to variable thickness of machined samples.

  19. Mobile machine hazardous working zone warning system

    SciTech Connect

    Schiffbauer, W.H.; Ganoe, C.W.

    1996-12-31

    A warning system is provided for a mobile working machine to alert an individual of a potentially dangerous condition in the event the individual strays into a hazardous working zone of the machine. The warning system includes a transmitter mounted on the machine and operable to generate a uniform magnetic field projecting beyond an outer periphery of the machine in defining a hazardous working zone around the machine during operation thereof. A receiver, carried by the individual and activated by the magnetic field, provides an alarm signal to alert the individual when he enters the hazardous working zone of the machine.

  20. Mobile machine hazardous working zone warning system

    DOEpatents

    Schiffbauer, William H.; Ganoe, Carl W.

    1999-01-01

    A warning system is provided for a mobile working machine to alert an individual of a potentially dangerous condition in the event the individual strays into a hazardous working zone of the machine. The warning system includes a transmitter mounted on the machine and operable to generate a uniform magnetic field projecting beyond an outer periphery of the machine in defining a hazardous working zone around the machine during operation thereof. A receiver, carried by the individual and activated by the magnetic field, provides an alarm signal to alert the individual when he enters the hazardous working zone of the machine.