The association between hematological parameters and metabolic syndrome in Iranian men: A single center large-scale study.

PubMed

Ahmadzadeh, Jamal; Mansorian, Behnam; Attari, Mohammad Mirza-Aghazadeh; Mohebbi, Ira; Naz-Avar, Raha; Moghadam, Karaim; Ghareh-Bagh, Seyyed Adel Khoshbou

Some studies have demonstrated that metabolic syndrome is associated with hematological parameters. The present study explores the relationship between hematological parameters and numbers of metabolic syndrome conditions in Iranian men. This cross-sectional study included 11,114 participants who were professional drivers of commercial motor vehicles, and were enrolled in the Iranian Health Surveys between 2014 and 2016. Diagnosis of metabolic syndrome was made according to International Diabetes Federation criteria. Clinical data, including anthropometric measurements and serum parameters, were collected. Odds ratios for hematological parameters and metabolic syndrome were calculated using binary logistic regression models. We found that hemoglobin; platelet, and white blood cell counts increased with increasing numbers of metabolic syndrome components (p<0.05 for all). The odds ratio of metabolic syndrome significantly increased across successive quartiles of platelet (1.00, 1.25, 1.29, and 1.51) and white blood cell counts (1.00, 1.51, 1.79, and 2.11) with the lowest quartile as the referent group. Similar associations for hemoglobin and hematocrit in the top quartile were also observed. We did not observe any significant difference in the mean of neutrophil count, mean platelet volume (MPV), red cell distribution width, or platelet distribution width among participants with or without metabolic syndrome. Our findings indicate that high levels of major hematological parameters such as hemoglobin, hematocrit, as well as platelet and white blood cell counts could be novel indicators for the development of metabolic syndrome. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients.

PubMed

Yuruk, Koray; Bartels, Sebastiaan A; Milstein, Dan M J; Bezemer, Rick; Biemond, Bart J; Ince, Can

2012-03-01

There is little clinical evidence that red blood cell (RBC) transfusions improve oxygen availability at the microcirculatory level. We tested the hypotheses that anemia in chronically anemic patients with relatively healthy microcirculation would be associated with low tissue hemoglobin (Hb) and tissue oxygenation levels and that these conditions would be improved after RBC transfusions. Near-infrared spectroscopy (NIRS) was used to determine tissue oxygen saturation (StO(2)) and tissue Hb index (THI; an index of the amount of Hb in the NIRS measurement volume) in the thenar eminence and sublingual tissue before and 30 minutes after RBC transfusions in 20 chronically anemic hematology outpatients. Data are presented as median (25%-75%). The patients received three (two to three) bags of RBCs in saline-adenine-glucose-mannitol with an age of 21 (7-21) days, which was infused intravenously at the rate of 0.7 bag/hr. RBC transfusions significantly increased hematocrit level from 26% (24%-28%) to 32% (30%-34%; p < 0.0001), Hb level from 8.2 (7.6-8.9) g/dL to 11.0 (9.9-11.8) g/dL (p < 0.0001), whole blood viscosity from 3.4 (3.1-3.5) mPa/sec to 4.2 (4.0-4.5) mPa/sec (p < 0.0001), thenar StO(2) from 81% (80%-84%) to 86% (81%-89%; p = 0.002), thenar THI from 11.2 (9.3-13.3) AU to 13.7 (9.7-15.3) AU (p = 0.024), sublingual StO(2) from 86% (81%-89%) to 91% (86%-92%; p < 0.0001), and sublingual THI from 15.2 (13.0-17.4) AU to 17.2 (13.5-19.7) AU (p = 0.040). Although anemia in chronically anemic hematology outpatients was not associated with low StO(2) and THI levels, RBC transfusions were successful in improving these variables. © 2011 American Association of Blood Banks.

Aircrew Automated Escape Systems (AAES) In-Service Usage Data Analyses. Volume 2. Papers Presented at the Annual SAFE Symposium (21st), San Antonio, Texas, 5,6,7,8 November 1983.

DTIC Science & Technology

1983-11-05

PILOT OF HIS INJURY AND PILOT RETURNED TO BASE RIO SUSTAINED MINIMAL ( WHIPLASH ) INJURY CAUSE WEIGHT OF HELMET AND MASK ON RiO’S HEAD WHILE IN...John Vetter (ESA-31 Division Head ). As has most unfortunately, despite the best of intentions of the team members to, for once, present the drafts...WARMINSTER NAVAIRTESTCEN (SY-70) PAXRIV NAVWPNCEN (64) CHINA LAKE NAVORDSTA (51) INDIAN HEAD NAVSAFECEN NORFOLK AFISC/SEL NORTON AFB,CA PACMISTESTCEN 1131 U.S

Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.

PubMed

Botthof, Jan Gregor; Bielczyk-Maczyńska, Ewa; Ferreira, Lauren; Cvejic, Ana

2017-05-30

RAD51 is an indispensable homologous recombination protein, necessary for strand invasion and crossing over. It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two patients carrying dominant-negative mutations. FA is a hereditary DNA-repair disorder characterized by various congenital abnormalities, progressive bone marrow failure, and cancer predisposition. In this report, we describe a viable vertebrate model of RAD51 loss. Zebrafish rad51 loss-of-function mutants developed key features of FA, including hypocellular kidney marrow, sensitivity to cross-linking agents, and decreased size. We show that some of these symptoms stem from both decreased proliferation and increased apoptosis of embryonic hematopoietic stem and progenitor cells. Comutation of p53 was able to rescue the hematopoietic defects seen in the single mutants, but led to tumor development. We further demonstrate that prolonged inflammatory stress can exacerbate the hematological impairment, leading to an additional decrease in kidney marrow cell numbers. These findings strengthen the assignment of RAD51 as a Fanconi gene and provide more evidence for the notion that aberrant p53 signaling during embryogenesis leads to the hematological defects seen later in life in FA. Further research on this zebrafish FA model will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the cellular role of RAD51.

Hematology and serum biochemistry comparison in wild and captive Central American river turtles (Dermatemys mawii) in Tabasco, Mexico.

PubMed

Rangel-Mendoza, Judith; Weber, Manuel; Zenteno-Ruiz, Claudia E; López-Luna, Marco A; Barba-Macías, Everardo

2009-10-01

Hematological and serum biochemistry analyses were determined on 51 Central American river turtles (Dermatemys mawii) during the dry and rainy seasons of 2006. Turtles came from two sites: Pantanos de Centla Biosphere Reserve and a turtle breeding farm, both located in Tabasco State, Mexico. Physical examination and body measures of animals were performed. Incidence and prevalence of hemoparasites were explored. Captive organisms were in poor physical condition while wild turtles were apparently healthy. There were differences in several hematological parameters related with the condition and the season. During the dry season captive turtles exhibited higher levels of uric acid and urea, as well as lower levels of glucose. Haemogregarina sp. was detected in 100% of the wild individuals, but not in captive individuals. Its incidence was greater during the rainy season. This is the first health assessment and hematology study of this critically endangered species.

[Clinical hematological symptoms of vitamin B12 deficiency in old age : Summarized overview of this year's symposium of the Working Group "Anemia in the Aged" on the occasion of the annual conference of the German Geriatric Society (DGG) in Frankfurt].

PubMed

Röhrig, Gabriele; Gütgemann, Ines; Kolb, Gerald; Leischker, Andreas

2018-05-23

The interdisciplinary symposium of the working group "anemia in the aged" on the occasion of the annual conference of the German Society of Geriatrics focused this year on vitamin B 12 deficiency in aged patients. Experts from hematopathology, clinical geriatrics and geriatric hematology presented the case of a 78-year-old woman and an interdisciplinary discussion was held on the epidemiology, clinical aspects as well as diagnostic and therapeutic steps. This article reviews the symposium on vitamin B 12 deficiency in the aged in the context of the currently available literature.

Hematologic and plasma biochemical reference intervals for Morelet's crocodiles (Crocodylus moreletii) in the northern wetlands of Campeche, Mexico.

PubMed

Padilla, Sergio E; Weber, Manuel; Jacobson, Elliott R

2011-07-01

Health surveys and hematologic and plasma biochemical analyses were conducted in 52 free-ranging and 51 captive Morelet's crocodiles (Crocodylus moreletii) in Campeche, Mexico, March-September 2007. Blood samples from 92 crocodiles (45 free-ranging and 47 captive) were collected for hematologic and plasma biochemical analyses. Average values of erythrocytes of free-ranging crocodiles were 1,046,166 cells/μl, and total white cells were 1.03 × 10(4) cells/μl. Captive crocodiles had erythrocyte and leukocyte values of 1,100,416 cells/μl and 8.51 × 10(3) cells/μl, respectively. There were no significant differences in values of erythrocytes or in hematocrit between free-ranging and captive crocodiles, or between sexes, or among size classes. Counts of leukocytes in free-ranging crocodiles were significantly higher than in captive individuals. The mean values of plasma analytes were 69.55 mg/l (glucose), 250.14 mg/l (cholesterol), 3.04 mg/l (uric acid), 2.70 mg/l (creatinine), and 20.20 IU/l (alanine aminotransferase). There were significant differences in cholesterol between free-ranging and captive crocodiles and between sexes.

Spread of Epidemic MRSA-ST5-IV Clone Encoding PVL as a Major Cause of Community Onset Staphylococcal Infections in Argentinean Children

PubMed Central

Sola, Claudia; Egea, Ana L.; Moyano, Alejandro J.; Garnero, Analia; Kevric, Ines; Culasso, Catalina; Vindel, Ana; Lopardo, Horacio; Bocco, José L.

2012-01-01

Background Community-associated methicillin-resistant Staphylococcus aureus-(CA-MRSA) strains have emerged in Argentina. We investigated the clinical and molecular evolution of community-onset MRSA infections (CO-MRSA) in children of Córdoba, Argentina, 2005–2008. Additionally, data from 2007 were compared with the epidemiology of these infections in other regions of the country. Methodology/Principal Findings Two datasets were used: i) lab-based prospective surveillance of CA-MRSA isolates from 3 Córdoba pediatric hospitals-(CBAH1-H3) in 2007–2008 (compared to previously published data of 2005) and ii) a sampling of CO-MRSA from a study involving both, healthcare-associated community-onset-(HACO) infections in children with risk-factors for healthcare-associated infections-(HRFs), and CA-MRSA infections in patients without HRFs detected in multiple centers of Argentina in 2007. Molecular typing was performed on the CA-MRSA-(n: 99) isolates from the CBAH1-H3-dataset and on the HACO-MRSA-(n: 51) and CA-MRSA-(n: 213) isolates from other regions. Between 2005–2008, the annual proportion of CA-MRSA/CA-S. aureus in Córdoba hospitals increased from 25% to 49%, P<0.01. Total CA-MRSA infections increased 3.6 fold-(5.1 to 18.6 cases/100,000 annual-visits, P<0.0001), associated with an important increase of invasive CA-MRSA infections-(8.5 fold). In all regions analyzed, a single genotype prevailed in both CA-MRSA (82%) and HACO-MRSA(57%), which showed pulsed-field-gel electrophoresis-(PFGE)-type-“I”, sequence-type-5-(ST5), SCCmec-type-IVa, spa-t311, and was positive for PVL. The second clone, pulsotype-N/ST30/CC30/SCCmecIVc/t019/PVL+, accounted for 11.5% of total CA-MRSA infections. Importantly, the first 4 isolates of Argentina belonging to South American-USA300 clone-(USA300/ST8/CC8/SCCmecIVc/t008/PVL+/ACME−) were detected. We also demonstrated that a HA-MRSA clone-(pulsotype-C/ST100/CC5) caused 2% and 10% of CA-MRSA and HACO-MRSA infections respectively and was associated with a SCCmec type closely related to SCCmecIV(2B&5). Conclusions/Significance The dissemination of epidemic MRSA clone, ST5-IV-PVL+ was the main cause of increasing staphylococcal community-onset infections in Argentinean children (2003–2008), conversely to other countries. The predominance of this clone, which has capacity to express the h-VISA phenotype, in healthcare-associated community-onset cases suggests that it has infiltrated into hospital-settings. PMID:22291965

Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats.

PubMed

Azab, Khaled Shaaban; Bashandy, Mohamed; Salem, Mahmoud; Ahmed, Osama; Tawfik, Zaki; Helal, Hamed

2011-06-01

Royal jelly is a nutritive secretion produced by the worker bees, rich in proteins, carbohydrates, vitamins and minerals. The present study was designed to determine the possible protective effects of royal jelly against radiation induced oxidative stress, hematological, biochemical and histological alterations in male Wister albino rats. Male Wister albino rats were exposed to a fractionated dose of gamma radiation (2 Gy every 3 days up to 8 Gy total doses). Royal jelly was administrated (g/Kg/day) by gavages 14 days before exposure to the 1(st) radiation fraction and the treatment was continued for 15 days after the 1(st) irradiation fraction till the end of the experiment. The rats were sacrificed 3(rd), equivalent to 3rd post 2nd irradiation fraction, and equivalent to 3rd day post last irradiation fraction. In the present study, gamma- irradiation induced hematological, biochemical and histological effects in male Wister albino rats. In royal jelly treated irradiated group, there was a noticeable decrease recorded in thiobarbituric reactive substances concentration when compared to γ-irradiated group. Also, the serum nitric oxide concentration was significantly improved. The administration of royal jelly to irradiated rats according to the current experimental design significantly ameliorates the changes induced in serum lipid profile. Moreover, in royal jelly treated irradiated group, there was a noticeable amelioration recorded in all hematological parameters along the three experimental intervals. The microscopic examination of cardiac muscle of royal jelly treated irradiated rats demonstrated structural amelioration, improved nuclei and normal features of capillaries and veins in endomysium when compared to gamma-irradiated rats. It was suggested that the biochemical, hematological and histological amelioration observed in royal jelly (g/Kg/day) treated irradiated rats might be due to the antioxidant capacity of royal jelly active constituents.

42 CFR 51.8 - Annual reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Annual reports. 51.8 Section 51.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM Basic Requirements § 51.8 Annual reports...

50th Annual Scientific Meeting of the British Society for Haematology.

PubMed

Thomas, Angela E

2010-08-01

The 50th Annual Scientific Meeting of the British Society for Haematology was notable, not only for its golden anniversary, but also because it coincided with the eruption of the Icelandic volcano, Eyjafjallajökull, and the ensuing travel chaos. In total, 28 speakers from overseas were unable to reach Edinburgh, including a significant number of British speakers who were stranded. However, owing to the superb efforts of the conference organisers and Edinburgh International Conference Centre staff, teleconferencing equipment was installed and all speakers were contacted and able to give their talks on time. The program, consisting of simultaneous sessions and plenary lectures, covered not only recent advances in clinical and laboratory hematology, but also reflected on the contribution of British hematology to the international arena over the past 50 years.

133. 24 EAST 51ST STREET, FRONT DRAWING ROOM, NORTH WALL, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

133. 24 EAST 51ST STREET, FRONT DRAWING ROOM, NORTH WALL, LEADED GLASS WINDOW WITH CARVED WOOD REVEAL AND SURROUND - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

Proceedings of the 2nd Annual Conference on Atmospheric Contamination in Confined Spaces, 4 and 5 May 1966

DTIC Science & Technology

1966-12-01

to represent the Aerospace Medical Division and to add our welcome to that of the Aerospace Medicaf Research Laboratories to all the mem - bers of... OHP , hyperbaric oxygen) as a medical tool has yielded additional information on the hematologic effect of oxygen tensions manyfold greater than those...Studies of 20 other patients before and after exposure to OHP failed to reveal any evidence of in vivo hemolysis. MANNED SPACE FLIGHTS No hematologic

1. Historic American Buildings Survey E. W. Russell, Photographer, October ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey E. W. Russell, Photographer, October 17, 1935 51-69 Government St. BLOCK OF BUILDINGS ON GOVERNMENT ST. (S. SIDE) BETWEEN WATER AND ROYAL STREETS - 51-69 Government Street (Commercial Building), Mobile, Mobile County, AL

18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

Multiple paternity in polyandrous barn owls (Tyto alba).

PubMed

Henry, Isabelle; Antoniazza, Sylvain; Dubey, Sylvain; Simon, Céline; Waldvogel, Céline; Burri, Reto; Roulin, Alexandre

2013-01-01

In polyandrous species females produce successive clutches with several males. Female barn owls (Tyto alba) often desert their offspring and mate to produce a 2(nd) annual brood with a second male. We tested whether copulating during chick rearing at the 1(st) annual brood increases the male's likelihood to obtain paternity at the 2(nd) annual breeding attempt of his female mate in case she deserts their brood to produce a second brood with a different male. Using molecular paternity analyses we found that 2 out of 26 (8%) second annual broods of deserting females contained in total 6 extra-pair young out of 15 nestlings. These young were all sired by the male with whom the female had produced the 1(st) annual brood. In contrast, none of the 49 1(st) annual breeding attempts (219 offspring) and of the 20 2(nd) annual breeding attempts (93 offspring) of non-deserting females contained extra-pair young. We suggest that female desertion can select male counter-strategies to increase paternity and hence individual fitness. Alternatively, females may copulate with the 1(st) male to derive genetic benefits, since he is usually of higher quality than the 2(nd) male which is commonly a yearling individual.

40 CFR 51.320 - Annual air quality data report.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Annual air quality data report. 51.320... REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Reports Air Quality Data Reporting § 51.320 Annual air quality data report. The requirements for reporting air quality data collected...

40 CFR 51.320 - Annual air quality data report.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Annual air quality data report. 51.320... REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Reports Air Quality Data Reporting § 51.320 Annual air quality data report. The requirements for reporting air quality data collected...

40 CFR 51.320 - Annual air quality data report.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Annual air quality data report. 51.320... REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Reports Air Quality Data Reporting § 51.320 Annual air quality data report. The requirements for reporting air quality data collected...

40 CFR 51.320 - Annual air quality data report.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Reports Air Quality Data Reporting § 51.320 Annual air quality data report. The requirements for reporting air quality data collected... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Annual air quality data report. 51.320...

40 CFR 51.320 - Annual air quality data report.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Reports Air Quality Data Reporting § 51.320 Annual air quality data report. The requirements for reporting air quality data collected... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Annual air quality data report. 51.320...

31st Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2009

ERIC Educational Resources Information Center

Office of Special Education and Rehabilitative Services, US Department of Education, 2012

2012-01-01

This is the 31st Annual Report to Congress on the Implementation of the "Individuals with Disabilities Education Act," 2009. Section 664(d) of the "Individuals with Disabilities Education Act" ("IDEA") (P.L. 108-446), as reauthorized in 2004, requires that the Department of Education report annually on the progress…

Febuxostat as a Prophylaxis for Tumor Lysis Syndrome in Children with Hematological Malignancies.

PubMed

Kishimoto, Kenji; Kobayashi, Ryoji; Hori, Daiki; Sano, Hirozumi; Suzuki, Daisuke; Kobayashi, Kunihiko

2017-10-01

The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxostat (10 mg daily, n=20) or allopurinol (300 mg/m 2 daily, n=25) as a prophylaxis for TLS. A significant decrease of serum uric acid (UA) level was observed in patients with febuxostat over the first 2 days (6.6±3.8 mg/dl vs. 4.5±2.8 mg/dl, p<0.001). The febuxostat group also showed significant reduction of urinary UA/creatinine ratios during the first two days of treatment (0.98±0.85 vs. 0.51±0.26, p=0.010). No significant differences were observed between febuxostat-treated and allopurinol-treated patients regarding the percent change in serum UA level. Febuxostat had a notable effect in reducing serum UA level in children with hematological malignancies. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Multiple Paternity in Polyandrous Barn Owls (Tyto alba)

PubMed Central

Dubey, Sylvain; Simon, Céline; Waldvogel, Céline; Burri, Reto; Roulin, Alexandre

2013-01-01

In polyandrous species females produce successive clutches with several males. Female barn owls (Tyto alba) often desert their offspring and mate to produce a 2nd annual brood with a second male. We tested whether copulating during chick rearing at the 1st annual brood increases the male's likelihood to obtain paternity at the 2nd annual breeding attempt of his female mate in case she deserts their brood to produce a second brood with a different male. Using molecular paternity analyses we found that 2 out of 26 (8%) second annual broods of deserting females contained in total 6 extra-pair young out of 15 nestlings. These young were all sired by the male with whom the female had produced the 1st annual brood. In contrast, none of the 49 1st annual breeding attempts (219 offspring) and of the 20 2nd annual breeding attempts (93 offspring) of non-deserting females contained extra-pair young. We suggest that female desertion can select male counter-strategies to increase paternity and hence individual fitness. Alternatively, females may copulate with the 1st male to derive genetic benefits, since he is usually of higher quality than the 2nd male which is commonly a yearling individual. PMID:24244622

Clinical outcomes of TS-1 chemotherapy for advanced and recurrent gastric cancer.

PubMed

Lee, Sung Ryol; Kim, Hyung Ook; Yoo, Chang Hak

2011-09-01

Titanium silicate (TS)-1 chemotherapy has been widely used against gastric cancer in Japan. The aim of the present study was to assess the efficacy and hematological safety of TS-1 as treatment for advanced and recurrent gastric cancer. From September 2006 to February 2011, 51 advanced or recurrent gastric cancers were treated with TS-1. One course of treatment consisted of 40, 50, or 60 mg/m(2) of TS-1 twice a day for 28 days, followed by withdrawal for two weeks. The primary end point was progression-free survival (PFS), and the secondary end point was overall survival (OS). The disease control rate was 39.2% (complete response, 0/51; partial response, 6/51; stable disease, 14/51; progressive disease, 23/51; not evaluable, 8/51). The median PFS was 4.0 months (95% confidence interval [CI], 2.2 to 5.7); the median PFS of the advanced group was 6.0 months (95% CI, 2.8 to 9.1), and the median PFS of the recurrent group was 3.0 months (95% CI, 1.8 to 4.1). The median OS was 11.0 months (95% CI, 6.3 to 15.6); the median OS of the advanced group was 10.0 months (95% CI, 4.9 to 15.0), and the median OS of the recurrent group was 14.0 months (95% CI, 4.1 to 23.8). Grade 3 or 4 hematological toxicity occurred in three patients (5.9%), anemia occurred in two patients (3.9%), and thrombocytopenia occurred in one patient (2%). TS-1 chemotherapy was safe and effective, with relatively long PFS and OS in patients with advanced and recurrent gastric cancers.

42 CFR 51.8 - Annual reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Annual reports. 51.8 Section 51.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE... Date Note: At 62 FR 53564, Oct. 15, 1997, § 51.8 was added. This section contains information...

42 CFR 51.8 - Annual reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Annual reports. 51.8 Section 51.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE... Date Note: At 62 FR 53564, Oct. 15, 1997, § 51.8 was added. This section contains information...

42 CFR 51.8 - Annual reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Annual reports. 51.8 Section 51.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE... Date Note: At 62 FR 53564, Oct. 15, 1997, § 51.8 was added. This section contains information...

42 CFR 51.8 - Annual reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Annual reports. 51.8 Section 51.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE... Date Note: At 62 FR 53564, Oct. 15, 1997, § 51.8 was added. This section contains information...

51st Yearbook of the National Reading Conference (San Antonio, Texas, December 5-8, 2001)

ERIC Educational Resources Information Center

Schallert, Diane L., Ed.; Fairbanks, Colleen M., Ed.; Worthy, Jo, Ed.; Maloch, Beth, Ed.; Hoffman, James V., Ed.

2002-01-01

This volume presents the 51st Yearbook of the National Reading Conference. Included in this volume are 28 research reports, six invited and award-winning addresses, and a conference summary by Deborah Dillion. Readers will find quantitative, qualitative, and mixed-methods studies throughout the volume about topics ranging from early literacy…

75 FR 30030 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... Governments; Number of Respondents: 51; Total Annual Responses: 51; Total Annual Hours: 102. (For policy... dialysis facilities are required to report. Form Number: CMS-265-94 (OMB : 0938-0236); Frequency: Yearly...,508; Total Annual Responses: 5,508; Total Annual Hours: 275,400. (For policy questions regarding this...

Effects of iridoid-anthocyanin extract of Cornus mas L. on hematological parameters, population and proliferation of lymphocytes during experimental infection of mice with Trichinella spiralis.

PubMed

Piekarska, Jolanta; Szczypka, Marianna; Kucharska, Alicja Z; Gorczykowski, Michał

2018-05-01

The influence of iridoid-anthocyanin aqueous extract of cornelian cherry fruits (CM) on hematological parameters, lymphocyte subsets and proliferation during Trichinella spiralis infection in mice was investigated. CM (100 mg/kg) was administered orally to T. spiralis-infected mice six times within a period encompassing three days prior to the infection and three days after the infection (dai). CM increased the percentage of CD3 + , CD4 + cells and CD4 + /CD8 + ratio and decreased total count of CD8 + and CD19 + splenocytes (5 th dai). An increase in total count of CD4 + , CD3 + , CD19 + splenocytes was observed (21 st dai). CM elevated the percentage of CD4 + cells (7 th dai) and CD4 + /CD8 + ratio (21 st dai) in MLN. CM increased (14 th dai) and then reduced (21 st dai) the percentage of CD8 + MLN lymphocytes and decreased total count of MLN CD8 + cells (21 st dai) and B cells (14 th dai). An activation of lymphocyte proliferation in spleen and simultaneous decrease in MLN on 5 th dai was observed. An increase in red blood cells parameters (5 th dai) and in leukocyte count (7 th dai) was found. A rise in platelet count was noticed both on 5 th and 7 th dai. Moreover, the number of adult T. spiralis on 5 th dai in mice receiving CM extract was lower than in the control mice. These results suggested that iridoid-anthocyanin aqueous extract of CM stimulated murine immune response during T. spiralis infection. Copyright © 2018 Elsevier Inc. All rights reserved.

Serum amyloid A protein (SAA), haptoglobin (Hp) and selected hematological and biochemical parameters in wild mares before and after parturition.

PubMed

Krakowski, L; Bartoszek, P; Krakowska, I; Olcha, P; Piech, T; Stachurska, A; Brodzki, P

2017-03-01

The aim of the study was to evaluate physiological changes in hematological and biochemical parameters in mares in perinatal period. Blood samples were collected from 24 pregnant Polish Konik breed mares which were divided into two groups. The first group (Group - I, n=12) comprised mares living in the wild, in the reserve. The second group (Group - II, n=12) consisted of mares kept in stables. The blood was collected 2 weeks prior to the parturition, then 24 hours after the delivery, and then at the 7th and 21st day after foaling. When comparing the two groups before the parturition, no significant differences in terms of WBC, RBC, and Hb were found, however, there was a significant difference in MCV, MCH, LYM, NEU and SEG NEU (p≤0.05). In Group II, 24 hours after the parturition and at the 21st day after foaling, a significant raise in WBC, NEU and SEG NEU (p≤0.05) was detected. No significant differences in serum concentrations of proteins such as TP, Alb or Glb were observed. As to acute phase proteins, significant rise in SAA and Hp (p≤0.05) was found in the two examined groups 24 hours after the parturition. Yet, this rise remained within physiological range. The study revealed a certain degree of fluctuations in hematological parameters, in serum concentrations of acute-phase proteins and total proteins in the mares in the perinatal period. However, these changes remained still within physiological ranges and thus they do not indicate potential susceptibility to disorders of perinatal period.

Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome.

PubMed

Iurlo, Alessandra; Nobili, Alessandro; Latagliata, Roberto; Bucelli, Cristina; Castagnetti, Fausto; Breccia, Massimo; Abruzzese, Elisabetta; Cattaneo, Daniele; Fava, Carmen; Ferrero, Dario; Gozzini, Antonella; Bonifacio, Massimiliano; Tiribelli, Mario; Pregno, Patrizia; Stagno, Fabio; Vigneri, Paolo; Annunziata, Mario; Cavazzini, Francesco; Binotto, Gianni; Mansueto, Giovanna; Russo, Sabina; Falzetti, Franca; Montefusco, Enrico; Gugliotta, Gabriele; Storti, Sergio; D'Addosio, Ada M; Scaffidi, Luigi; Cortesi, Laura; Cedrone, Michele; Rossi, Antonella Russo; Avanzini, Paolo; Mauro, Endri; Spadea, Antonio; Celesti, Francesca; Giglio, Gianfranco; Isidori, Alessandro; Crugnola, Monica; Calistri, Elisabetta; Sorà, Federica; Rege-Cambrin, Giovanna; Sica, Simona; Luciano, Luigiana; Galimberti, Sara; Orlandi, Ester M; Bocchia, Monica; Tettamanti, Mauro; Alimena, Giuliana; Saglio, Giuseppe; Rosti, Gianantonio; Mannucci, Pier Mannuccio; Cortelezzi, Agostino

2016-11-29

About 40% of all patients with chronic myeloid leukemia are currently old or very old. They are effectively treated with imatinib, even though underrepresented in clinical studies. Furthermore, as it happens in the general population, they often receive multiple drugs for associated chronic illnesses. Aim of this study was to assess whether or not in imatinib-treated patients aged >75 years the exposure to polypharmacy (5 drugs or more) had an impact on cytogenetic and molecular response rates, event-free and overall survival, as well as on hematological or extra-hematological toxicity. 296 patients at 35 Italian hematological institutions were evaluated. Polypharmacy was reported in 107 patients (36.1%), and drugs more frequently used were antiplatelets, diuretics, proton pump inhibitors, ACE-inhibitors, beta-blockers, calcium channel blockers, angiotensin II receptors blockers, statins, oral hypoglycemic drugs and alpha blockers. Complete cytogenetic response was obtained in 174 patients (58.8%), 78 (26.4%) within 6 month, 63 (21.3%) between 7 and 12 months. Major molecular response was obtained in 153 patients (51.7%), 64 (21.6%) within the 12 month. One hundred and twenty-eight cases (43.2%) of hematological toxicity were recorded, together with 167 cases (56.4%) of extra-hematological toxicity. Comparing patients exposed to polypharmacy to those without, no difference was observed pertaining to the dosage of imatinib, cytogenetic and molecular responses and hematological and extra-hematological toxicity. Notwithstanding the several interactions reported in the literature between imatinib and some of the medications considered herewith, this fact does not seem to have a clinical impact on response rate and outcome.

40 CFR 81.356 - Virgin Islands.

Code of Federal Regulations, 2011 CFR

2011-07-01

... St. John St. Thomas 1 This date is November 15, 1990, unless otherwise noted. Virgin Islands—Ozone (1... Unclassifiable/Attainment St. Croix St. John St. Thomas 1 This date is October 18, 2000, unless otherwise noted... St. Thomas 1 This date is June 15, 2004, unless otherwise noted. Virgin Islands—PM2.5 (Annual NAAQS...

Outbreak of OXA-48-Producing Klebsiella pneumoniae Involving a Sequence Type 101 Clone in Batna University Hospital, Algeria

PubMed Central

Loucif, Lotfi; Kassah-Laouar, Ahmed; Saidi, Mahdia; Messala, Amina; Chelaghma, Widad

2016-01-01

Seven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the blaOXA-48, blaCTX-M-15, blaSHV-1, and blaTEM-1D genes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The blaOXA-48 gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital. PMID:27645236

CONNECT: Linking Energy, Security, and Prosperity in the 21st Century - JISEA 2017 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

This report demonstrates 2016 highlights of the Joint Institute for Strategic Energy Analysis' (JISEA's) work. The Annual Report overviews JISEA's research and analysis accomplishments in natural gas and methane emissions; nuclear-renewable hybrid energy systems; the 21st Century Power Partnership; and more.

Annual Convention in St. Louis: A Dynamic Convergence

ERIC Educational Resources Information Center

Emeagwali, N. Susan

2012-01-01

Nearly 3,000 career and technical educators from across the country converged upon St. Louis, Missouri, for the premier professional development event in career and technical education (CTE). The Association for Career and Technical Education (ACTE) held its Annual Convention and Career Tech Expo November 17-19, bringing together teachers,…

CATV: The New Communicator. 21st Annual NCTA Convention Official Transcript. Technical Volume.

ERIC Educational Resources Information Center

National Cable Television Association, Inc., Washington, DC.

The proceedings of the 21st annual National Cable Television Association convention are presented under the following groupings: short haul microwave systems, satellite/cable system engineering, market studies, FCC (Federal Communications Commission) technical rules and standards, program origination, cable channel allocations, cable system…

Molecular biology of Homo sapiens: Abstracts of papers presented at the 51st Cold Spring Harbor symposium on quantitative biology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J.D.; Siniscalco, M.

This volume contains abstracts of papers presented at the 51st Cold Springs Harbor Symposium on Quantitative Biology. The topic for this meeting was the ''Molecular Biology of Homo sapiens.'' Sessions were entitled Human Gene Map, Human Cancer Genes, Genetic Diagnosis, Human Evolution, Drugs Made Off Human Genes, Receptors, and Gene Therapy. (DT)

6 CFR 9.51 - Semi-annual compilation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Semi-annual compilation. 9.51 Section 9.51 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING.... (c) Information that involves intelligence matters shall be reported only to the Select Committee on...

An oral Hemokine™, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

PubMed Central

Faller, Douglas V.; Castaneda, Serguei A.; Zhou, Daohong; Vedamony, Merriline; Newburger, Peter E.; White, Gary L.; Kosanke, Stanley; Plett, P. Artur; Orschell, Christie M.; Boosalis, Michael S.; Perrine, Susan P.

2017-01-01

An oral therapeutic which reduces duration of cytopenias and is active following accidental radiation exposures is an unmet need in radiation countermeasures. Alpha methylhydrocinnamate (ST7) prolongs STAT-5 phosphorylation, reduces growth-factor dependency of multi-lineage cell lines, and stimulates erythropoiesis. Here, ST7 and its isomers were studied for their effects on myeloid progenitors and hematopoietic stem cells (HSCs) following radiation, in nonhuman primates, and murine irradiation models. Addition of ST7 or ST7-S increased CFU-GM production by 1.7-fold (p<0.001), reduced neutrophil apoptosis comparable to G-CSF, and enhanced HSC survival post-radiation by 2-fold, (p=0.028). ST7 and ST7-S administered in normal baboons increased ANC and platelet counts by 50–400%. In sub-lethally-irradiated mice, ANC nadir remained >200/mm3 and neutropenia recovered in 6 days with ST7 treatment and 18 days in controls (p<0.05). In lethally-irradiated mice, marrow pathology at 15 days was hypocellular (10% cellularity) in controls, but normal (55–75% cellularity) with complete neutrophil maturation with ST7-S treatment. Following lethal irradiation, ST7, given orally for 4 days, reduced mortality, with 30% survival in ST7-animals vs 8% in controls, (p<0.05). Collectively, the studies indicate that ST7 and ST7-S enhance myeloid recovery post-radiation and merit further evaluation to accelerate hematologic recovery in conditions of radiation-related and other marrow hypoplasias. PMID:27888688

Assessment of theileria equi and babesia caballi infections in equine populations in Egypt by molecular, serological and hematological approaches

USDA-ARS?s Scientific Manuscript database

Background: Equine piroplasmosis caused by Theileria equi, Babesia caballi, or both, cause significant economic losses in the equine industry and remains uncontrolled in Egypt. Methods: T. equi and B. caballi infections were assessed in blood from 88 horses and 51 donkeys from different localities ...

Measuring the level of agreement in hematologic and biochemical values between blood sampling sites in leatherback sea turtles (Dermochelys coriacea).

PubMed

Stewart, Kimberly; Mitchell, Mark A; Norton, Terry; Krecek, Rosina C

2012-12-01

Conservation programs to protect endangered sea turtles are being instituted worldwide. A common practice in these programs is to collect blood to evaluate the health of the turtles. Several different venipuncture sites are used to collect blood from sea turtles for hematologic and biochemistry tests, depending on the species. To date, it is unknown what affect venipuncture site may have on sample results. The purpose of this study was to measure the level of agreement between hematologic and biochemistry values collected from the dorsal cervical sinus and the interdigital vein of leatherback (Dermochelys coriacea) sea turtles. Paired heparinized blood samples were obtained from the dorsal cervical sinus and the interdigital vein of 12 adult female nesting leatherback sea turtles on Keys Beach, St. Kitts, West Indies. Even though the sample population was small, the data for each chemistry were normally distributed, except for creatine kinase (CK). There was no significant difference when comparing biochemistry or hematologic values by venipuncture site, except for CK (P = 0.02). The level of agreement between sampling sites was considered good for albumin, calcium, globulin, glucose, packed cell volume, phosphorus, potassium, sodium, total protein, total solids, uric acid, white blood cell count, and all of the individual white cell types, while the level of agreement for aspartate aminotransferase and CK were considered poor. This information, coupled with the fact that the interdigital vein affords a less-invasive procedure, demonstrates that the interdigital vein is an appropriate location to use when establishing a hematologic and biochemical profile for leatherback sea turtles.

Discover the Hidden Jewels in Your Library and Sharing the Wealth through Collaboration. Selected Papers from PIALA 2011, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (21st, Kosrae, Federated States of Micronesia, November 14-17, 2011)

ERIC Educational Resources Information Center

Drake, Paul B., Ed.

2012-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 21st annual conference was held in Kosrae, Federated States of Micronesia, November 14-17, 2011. The volume begins with a listing of the members of the PIALA 2011 Planning…

Proceedings of the 2013 Annual Meeting of the Canadian Mathematics Education Study Group = Actes De La Rencontre Annuelle 2013 Du Groupe Canadien D'étude en Didactique Des Mathématiques (37th, St. Catharines, Ontario, Canada, May 24-28, 2013)

ERIC Educational Resources Information Center

Oesterle, Susan, Ed.; Allan, Darien, Ed.

2014-01-01

This submission contains the Proceedings of the 2013 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at Brock University in St. Catharines, Ontario. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning. The aims of the…

Estimation of the Hematological Change of Red Blood Cell and Platelet Count of Healthy Pregnant Women in Saudi Arabia

NASA Astrophysics Data System (ADS)

Hana, M. M.; Ramzun, M. R.; Nabela, Z.; Zahirah, N. A. N.; Razak, Nik Noor Ashikin Nik Abdul; Azhar, A. R.; Iskandar, S. M.; Nursakinah, S.

2018-04-01

Tremendous changes in hematological values were noticed throughout trimesters of pregnancy. This study is aimed to provide a reference for hematological values based on trimesters, focused on the parameter of red blood cell (RBCs) and platelets (PLTs). There were 4075 local Saudi pregnant women were involved, attending the Maternity and Children Hospital in Dammam and King Fahad University Hospital in Al-Khobar, between 2013 to 2015. The statistical analysis, such as frequency and descriptive were performed. Overall, this study revealed a decline in RBCs and PLTs throughout pregnancy. The RBC, HCT, MPV and MCH mean values were found decreases in the 2nd trimester but increased in the 3rd trimester. On the contrary, the MCV, MCHC, and RDW showed increases in the 2nd trimester and decreased in the 3rd trimester. The changes of the RBCs parameters in 3rd trimester compared to 1st trimester shows increased for MCV while the RBC, HCT, MCH and MCHC decreased. Besides that, most of the respondent suffering from anemia. The hematological values after delivery show decreased for RBC, HCT, MCV, MCH and MPV but an increase in the MCHC, RDW and PLT. Thus, it is highly recommended to request for a complete blood cell screening during pregnancy to provide a better healthcare of the maternal and fetus.

Natrona County/Casper, Wyoming. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-07-16

el_ STATON STATbON NA ViAlS 24 HOUR AMOUNTS IN INCHES MYwA JAN FES MAR APR MAY JUN JUL. AUG. SEP. OCT. NOV. OEC MOLTS ., . 3. 7. S__3 5. 5.1 2 A T. k...344I1 6? -! -" 171 1*1 16 16 _311_302 lement Ill) ZX8 21 M e. Obra . Mame me. of Newe Wilk To e mtw" Rol. lio. *Towl wet sikll, a". Poin IN ,e " ’ ..4...569 NATRONA CO/CASPER WY 73-61 $’AT ON ST-ATIO. N ANE viAls MRS L S T i JAN FES MAN APR MAY JUNl Jut AUG SEP OCT NO0V DEC ANNUAL MEAN 124*61824.&2324

Biology Division annual progress report for period ending December 31, 1968

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1969-07-01

Brief summaries are presented of research in progress in the fields of radiobiology, genetics, hematology, immunology, physsiology, biochemistry, bacteriology, enzymology, microbiology, photosynthesis, biophysics, radiation protection, and related fields. A list is included of 212 publications in the world literature that report results of completed studies. (CH)

Check Sample Abstracts.

PubMed

Alter, David; Grenache, David G; Bosler, David S; Karcher, Raymond E; Nichols, James; Rajadhyaksha, Aparna; Camelo-Piragua, Sandra; Rauch, Carol; Huddleston, Brent J; Frank, Elizabeth L; Sluss, Patrick M; Lewandrowski, Kent; Eichhorn, John H; Hall, Janet E; Rahman, Saud S; McPherson, Richard A; Kiechle, Frederick L; Hammett-Stabler, Catherine; Pierce, Kristin A; Kloehn, Erica A; Thomas, Patricia A; Walts, Ann E; Madan, Rashna; Schlesinger, Kathie; Nawgiri, Ranjana; Bhutani, Manoop; Kanber, Yonca; Abati, Andrea; Atkins, Kristen A; Farrar, Robert; Gopez, Evelyn Valencerina; Jhala, Darshana; Griffin, Sonya; Jhala, Khushboo; Jhala, Nirag; Bentz, Joel S; Emerson, Lyska; Chadwick, Barbara E; Barroeta, Julieta E; Baloch, Zubair W; Collins, Brian T; Middleton, Owen L; Davis, Gregory G; Haden-Pinneri, Kathryn; Chu, Albert Y; Keylock, Joren B; Ramoso, Robert; Thoene, Cynthia A; Stewart, Donna; Pierce, Arand; Barry, Michelle; Aljinovic, Nika; Gardner, David L; Barry, Michelle; Shields, Lisa B E; Arnold, Jack; Stewart, Donna; Martin, Erica L; Rakow, Rex J; Paddock, Christopher; Zaki, Sherif R; Prahlow, Joseph A; Stewart, Donna; Shields, Lisa B E; Rolf, Cristin M; Falzon, Andrew L; Hudacki, Rachel; Mazzella, Fermina M; Bethel, Melissa; Zarrin-Khameh, Neda; Gresik, M Vicky; Gill, Ryan; Karlon, William; Etzell, Joan; Deftos, Michael; Karlon, William J; Etzell, Joan E; Wang, Endi; Lu, Chuanyi M; Manion, Elizabeth; Rosenthal, Nancy; Wang, Endi; Lu, Chuanyi M; Tang, Patrick; Petric, Martin; Schade, Andrew E; Hall, Geraldine S; Oethinger, Margret; Hall, Geraldine; Picton, Avis R; Hoang, Linda; Imperial, Miguel Ranoa; Kibsey, Pamela; Waites, Ken; Duffy, Lynn; Hall, Geraldine S; Salangsang, Jo-Anne M; Bravo, Lulette Tricia C; Oethinger, Margaret D; Veras, Emanuela; Silva, Elvia; Vicens, Jimena; Silva, Elvio; Keylock, Joren; Hempel, James; Rushing, Elizabeth; Posligua, Lorena E; Deavers, Michael T; Nash, Jason W; Basturk, Olca; Perle, Mary Ann; Greco, Alba; Lee, Peng; Maru, Dipen; Weydert, Jamie Allen; Stevens, Todd M; Brownlee, Noel A; Kemper, April E; Williams, H James; Oliverio, Brock J; Al-Agha, Osama M; Eskue, Kyle L; Newlands, Shawn D; Eltorky, Mahmoud A; Puri, Puja K; Royer, Michael C; Rush, Walter L; Tavora, Fabio; Galvin, Jeffrey R; Franks, Teri J; Carter, James Elliot; Kahn, Andrea Graciela; Lozada Muñoz, Luis R; Houghton, Dan; Land, Kevin J; Nester, Theresa; Gildea, Jacob; Lefkowitz, Jerry; Lacount, Rachel A; Thompson, Hannis W; Refaai, Majed A; Quillen, Karen; Lopez, Ana Ortega; Goldfinger, Dennis; Muram, Talia; Thompson, Hannis

2009-02-01

The following abstracts are compiled from Check Sample exercises published in 2008. These peer-reviewed case studies assist laboratory professionals with continuing medical education and are developed in the areas of clinical chemistry, cytopathology, forensic pathology, hematology, microbiology, surgical pathology, and transfusion medicine. Abstracts for all exercises published in the program will appear annually in AJCP.

Disease features in horses with induced equine monocytic ehrlichiosis (Potomac horse fever).

PubMed

Dutta, S K; Penney, B E; Myrup, A C; Robl, M G; Rice, R M

1988-10-01

Fifty-five horses were inoculated IV and/or SC with materials containing Ehrlichia risticii, ie, infected whole blood, buffy coat cells, or cell culture, to study clinical and hematologic features of equine monocytic ehrlichiosis (Potomac horse fever). Major clinical and hematologic features of induced E risticii infection were biphasic increase in rectal temperature with peak increases of 38.9 C and 39.3 C on postinoculation days (PID) 5 and 12, respectively; depression; anorexia; decreased WBC count (maximal decrease of 47% on PID 12); and diarrhea from PID 14 to PID 18. Increased WBC count was an inconsistent feature, with a maximal increase of 51.5% on PID 20. During times of decreased and increased WBC counts, lymphocyte/neutrophil ratios remained fairly constant. However, not all horses had all clinical and hematologic features, and these features were present in different degrees among horses. Increased rectal temperature, depression, anorexia, and decreased WBC count were more consistent features, whereas diarrhea developed in 73% of the horses. Of 55 horses, 39 (71%) had all clinical and hematologic features of the disease (classic disease), whereas 16 (29%) horses did not have greater than or equal to 1 of these features (nonclassic disease). The E risticii titer in the blood (ehrlichemia) was maximum during the peak increase in rectal temperature. In 55 horses, mortality was 9%. Significant differences (P greater than 0.5) in clinical and hematologic features were not detected between horses that survived and those that died of E risticii infection.

28 CFR 345.51 - Inmate pay.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Inmate pay. 345.51 Section 345.51... (FPI) INMATE WORK PROGRAMS Inmate Pay and Benefits § 345.51 Inmate pay. (a) Grade levels. Inmate workers in FPI locations receive pay at five levels ranging from 5th grade pay (lowest) to 1st grade pay...

Effects of air pollution on hematological parameters in passerine birds.

PubMed

Llacuna, S; Gorriz, A; Riera, M; Nadal, J

1996-07-01

The effects of atmospheric air pollution on some hematological, and bioquimic parameters, of passerine birds were analyzed. The studies were undertaken in the area of Cercs (polluted area in Spain), where there is a coal-fired power plant that emanates SO2, NOx, and particles, and the area of St. Jaume de Frontanya (nonpolluted area) located 40 km from the area of Cercs with similar climatology, relief, and altitude, but without air pollution. The results showed that there was a significant decrease in the erythrocyte count, and an increase in erythrocyte size in specimens from the polluted area. An increase in pre-albumines and a decrease in beta-globulines in Emberiza cia was observed, while an increase in transaminases (GOT and GPT), and a decrease in weight in Turdus merula from the polluted zone was observed.

An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.

PubMed

Faller, Douglas V; Castaneda, Serguei A; Zhou, Daohong; Vedamony, Merriline; Newburger, Peter E; White, Gary L; Kosanke, Stanley; Plett, P Artur; Orschell, Christie M; Boosalis, Michael S; Perrine, Susan P

2017-03-01

An oral therapeutic which reduces duration of cytopenias and is active following accidental radiation exposures is an unmet need in radiation countermeasures. Alpha methylhydrocinnamate (ST7) prolongs STAT-5 phosphorylation, reduces growth-factor dependency of multi-lineage cell lines, and stimulates erythropoiesis. Here, ST7 and its isomers were studied for their effects on myeloid progenitors and hematopoietic stem cells (HSCs) following radiation, in nonhuman primates, and murine irradiation models. Addition of ST7 or ST7-S increased CFU-GM production by 1.7-fold (p<0.001), reduced neutrophil apoptosis comparable to G-CSF, and enhanced HSC survival post-radiation by 2-fold, (p=0.028). ST7 and ST7-S administered in normal baboons increased ANC and platelet counts by 50-400%. In sub-lethally-irradiated mice, ANC nadir remained >200/mm 3 and neutropenia recovered in 6days with ST7 treatment and 18days in controls (p<0.05). In lethally-irradiated mice, marrow pathology at 15days was hypocellular (10% cellularity) in controls, but normal (55-75% cellularity) with complete neutrophil maturation with ST7-S treatment. Following lethal irradiation, ST7, given orally for 4days, reduced mortality, with 30% survival in ST7-animals vs 8% in controls, (p<0.05). Collectively, the studies indicate that ST7 and ST7-S enhance myeloid recovery post-radiation and merit further evaluation to accelerate hematologic recovery in conditions of radiation-related and other marrow hypoplasias. Copyright © 2016 Elsevier Inc. All rights reserved.

78 FR 15293 - Safety Zone; St. Patrick's Day Fireworks; Manitowoc River, Manitowoc, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-11

...-AA00 Safety Zone; St. Patrick's Day Fireworks; Manitowoc River, Manitowoc, WI AGENCY: Coast Guard, DHS... will hold its annual St. Patrick's Day fireworks display. This fireworks display will be launched from... as follows: Sec. 165.T09-0116 Safety Zone; St. Patrick's Day Fireworks; Manitowoc River, Manitowoc...

Proceedings of the 2011 Annual Meeting of the Canadian Mathematics Education Study Group = Actes De La Rencontre Annuelle 2011 Du Groupe Canadien D'étude en Didactique Des Mathématiques (35th, St. John's, Newfoundland, Canada, June 10-14, 2011)

ERIC Educational Resources Information Center

Liljedahl, Peter, Ed.; Oesterle, Susan, Ed.; Allan, Darien, Ed.

2012-01-01

This submission contains the Proceedings of the 2011 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at Memorial University of Newfoundland in St. John's, Newfoundland. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning.…

California Energy Systems for the 21st Century 2016 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Randwyk, J.; Boutelle, A.; McClelland, C.

The California Energy Systems for the 21st Century (CES-21) Program is a public-private collaborative research and development program between the California Joint Utilities1 and Lawrence Livermore National Laboratory (LLNL). The purpose of this annual report is to provide the California Public Utilities Commission (CPUC or Commission) with a summary of the 2016 progress of the CES-21 Program.

Philosophy of Education, 1972-1973. Proceedings of the Annual Meeting of the Far Western Philosophy of Education Society (21st, Pomona, California, December 1-3, 1972).

ERIC Educational Resources Information Center

Jelinek, James J., Ed.

The proceedings of the 21st annual meeting of the Far Western Philosophy of Education Society in 1972 are presented. The proceedings consisted of 20 addresses and responses. Titles include (1) Presidential Address: Competency-Based Education: Consensus Cognoscenti Versus Reconstructio Experientiae; (2) A Role for Philosophy in California and…

Research in Science Education, Volume 1990. Selected Refereed Papers from the Annual Conference of the Australasian Science Education Research Association (21st, Perth, Western Australia, July 1990).

ERIC Educational Resources Information Center

Gardner, Paul L., Ed.

1990-01-01

This book contains selected refereed papers from the 21st Annual Conference of the Australasian Science Education Research Association. The papers are as follows: "A Learning Model for Science Education: Developing Teaching Strategies" (Appleton); "Researching Balance between Cognition and Affect in Science Teaching" (Baird et…

Oregon Schools for the 21st Century: Oregon Report Card 1993-94. An Annual Report to the State Legislature on Oregon's Public Schools.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem.

The Oregon Report Card is an annual portrait of the state's public schools. The first five sections describe statewide progress toward implementing Oregon's Educational Act for the 21st Century, some of the state's exemplary school-improvement programs, and the clear relationship between Oregon's program and national education goals. The remaining…

77 FR 41168 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-12

... Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island AGENCY: National Marine Fisheries... taking of northern fur seals on St. Paul Island. St. Paul's petition requests that NMFS revise the... seals; take a total of up to 3,000 fur seals annually compared to 2,000 currently allowed, including up...

Gray wolf density and its association with weights and hematology of pups from 1970 to 1988

USGS Publications Warehouse

DelGiudice, Glenn D.; Mech, L. David; Seal, U.S.

1991-01-01

We examined weights and hematologic profiles of gray wolf (Canis lupus) pups and the associated wolf density in the east-central Superior National Forest of northeastern Minnesota (USA) during 1970 to 1988. We collected weight and hematologic data from 117 pups (57 females, 60 males) during 1 September to 22 November each year. The wolf density (wolves/800 km2) trend was divided into three phases: high (72 ± 7), 1970 to 1975; medium (44 ± 2), 1976 to 1983; and low (27 ± 2), 1984 to 1988. Wolf numbers declined (P = 0.0001) 39 and 63% from 1970 to 1975 to 1976 to 1983 and from 1970 to 1975 to 1984 to 1988, respectively. Weight was similar between male and female pups and did not vary as wolf density changed. Mean hemoglobin (P = 0.04), red (P = 0.0001) and white blood cells (P = 0.002), mean corpuscular volume, mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin (P = 0.0001) did differ among the multi-annual phases of changing wolf density. Weight and hematologic data also were compared to values from captive wolf pups. The high, but declining wolf density was associated with macrocytic, normochromic anemia in wolf pups, whereas the lowest density coincided with a hypochromic anemia. Although hematologic values show promise for assessing wolf pup condition and wolf population status, they must be used cautiously until data are available from other populations.

Outcome of Frontline Treatment with "Generic" Imatinib In Adult Patients with Chronic Myeloid Leukemia in Algerian Population: A Multicenter Study.

PubMed

Entasoltan, B; Bekadja, M A; Touhami, H; Mehalhal, N; Zouaoui, Z; Mesli, N; Talbi, M; Bachiri, A; Michallet, M

2017-01-01

In a developing country like Algeria, such expensive therapy is not available. Alternative approaches are needed to help these adult. In Algeria 'imatib' (CIPLA-India) was introduced in 2006; but no study has been published yet in the North Africa region regarding response and outcome of this copy in CML patients. The goal of this multicenter study is to characterize newly adult CML in the western region of Algeria and to assess the effectiveness and safety of imatib (IM, copy) as frontline therapy for patients with CML. The study was carried out in 7 hematology centers in the western Algeria. Patients, who were diagnosed to be suffering from CML between January 1st, 2007 and December 31st, 2014 were selected for data analysis. All patients received a copy preparation, consisting of the alpha crystal form of imatinib, (IM, copy) at an oral dose of 400 mg daily and monitored for tolerance and side effects while on therapy. Between January 2007 and December 2014, 355 patients with CML were treated with imatib (Copy). The median follow- up of the study was 46 months (range: 13-107 months). Complete hematological response (CHR) was seen in 83% of patients within 3 months. According to the Sokal score, 72% patients with low, 78% with intermediate and 69% with high risk disease achieved a CHR in 3 months (p=0.26) and according to the EUTOS score, 81% of patients with low and 70% with high risk disease achieved a CHR in 3 months (p=0.08). The major molecular response (MMR) at six months (M6), M9, M12, M18 and M24 was 21%, 38%, 35%, 51% and 67% respectively and 34% of patients achieved a complete molecular response (CMR). The projected 5-year overall survival (OS) rate was 83%. Side effects of imatib (copy) in this study were similar to those reported previously for the entire imatinib mesylate treatment study and only 8% of patients were intolerant to imatib (copy) and treated with a second generation of BCR-ABL inhibitor. This study reflects real world experience treating patients with CML in a developing country and thus sheds light on differences in this population compared to Western countries. In conclusion, imatib (copy) is effective and safe in treating patients with CML in chronic phase and proves to have a durable outcome. To our knowledge this is the first study reporting the response to imatib (copy) in an Algerian population.

ENVIRONMENTAL SCIENCES IN THE 21ST CENTURY: PARADIGMS, OPPORTUNITIES, AND CHALLENGES

EPA Science Inventory

In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, Nashville, TN.. Society of Environmental Toxicology and Chemistry, Pensacola, FL. Pp. p. 180.

Bioavailability and rates...

Suspended sediment in the St. Francis River at St. Francis, Arkansas, 1986-95

USGS Publications Warehouse

Green, W. Reed; Barks, C. Shane; Hall, Alan P.

2000-01-01

Daily suspended-sediment concentrations were analyzed from the St. Francis River at St. Francis, Arkansas during 1986 through 1995. Suspended-sediment particle size distribution was measured in selected samples from 1978 through 1998. These data are used to assess changes in suspended-sediment concentrations and loads through time. Suspended-sediment concentrations were positively related to discharge. At higher flows, percent silt-clay was negatively related to discharge. Nonparametric trend analysis (Mann-Kendall test) of suspended-sediment concentration over the period of record indicated a slight decrease in concentration. Flow-adjusted residuals of suspended-sediment concentration also decreased slightly through the same period. No change was identified in annual suspended-sediment load or annual flow-weighted concentration. Continued monitorig of daily-suspended-sediment concentrations at this site and others, and similar data analysis at other sites where data are available will provide a better understanding of sediment transport withint the St. Francis River.

New frontiers in pediatric allogeneic stem cell transplantation

PubMed Central

Talano, Julie-An M.; Pulsipher, Michael A.; Symons, Heather J.; Militano, Olga; Shereck, Evan B.; Giller, Roger H.; Hancock, Laura; Morris, Erin; Cairo, Mitchell S.

2015-01-01

The inaugural meeting of “New Frontiers in Pediatric Allogeneic Stem Cell Transplantation” organized by the Pediatric Blood and Transplant Consortium (PBMTC) was held at the American Society of Pediatric Hematology and Oncology Annual Meeting. This meeting provided an international platform for physicians and investigators active in the research and utilization of pediatric allogeneic stem cell transplantation (AlloSCT) in children and adolescents with malignant and non-malignant disease, to share information and develop future collaborative strategies. The primary objectives of the conference included: 1) to present advances in AlloSCT in pediatric ALL and novel pre- and post-immunotherapy; 2) to highlight new strategies in alternative allogeneic stem cell donor sources for children and adolescents with non-malignant hematological disorders; 3) to discuss timing of immune reconstitution after AlloSCT and methods of facilitating more rapid recovery of immunity; 4) to identify strategies of utilizing AlloSCT in pediatric myeloproliferative disorders (MPD); 5) to develop diagnostic and therapeutic approaches to hematological complications post pediatric AlloSCT; 6) to enhance the understanding of new novel cellular therapeutic approaches to pediatric malignant and non-malignant hematological disorders; and 7) to discuss optimizing drug therapy in pediatric recipients of AlloSCT. This paper will provide a brief overview of the conference. PMID:24820213

Teaching Mathematics in New Times, Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated, Volume 1. (21st, Gold Coast, Australia, July 5-8, 1998).

ERIC Educational Resources Information Center

Kanes, Clive, Ed.; Goos, Merrilyn, Ed.; Warren, Elizabeth, Ed.

The first volume of this proceedings contains the papers presented at the 21st annual meeting of the Mathematics Education Research Group of Australasia. Papers include: (1) "Research, Rhetoric and Reality" (Lyn English); (2) "I Keep Six Honest Serving Men" (Peter Galbraith); (3) "The Intension/Intention of Teaching…

Unlocking the Transformational Power of Continuing Education. Proceedings of the Annual Meeting of the Association for Continuing Higher Education (71st, Philadelphia, Pennsylvania, November 15-18, 2009)

ERIC Educational Resources Information Center

Jerman, Jerry, Ed.

2009-01-01

The 2009 proceedings of the Association for Continuing Higher Education represent the professional presentations of the keynote sessions, the concurrent sessions, and the business meeting of the association's 71st annual conference, held at the Sheraton Society Hill Hotel in Philadelphia on November 15-18, 2009. The conference provided an engaging…

Teaching Mathematics in New Times, Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated, Volume 2. (21st, Gold Coast, Australia, July 5-8, 1998).

ERIC Educational Resources Information Center

Kanes, Clive, Ed.; Goos, Merrilyn, Ed.; Warren, Elizabeth, Ed.

The second volume of this proceedings contains the papers presented at the 21st annual meeting of the Mathematics Education Research Group of Australasia. Full papers include: (1) "Teachers Interpreting Algebra: Teachers' Views about the Nature of Algebra" (Brenda Menzel and David Clarke); (2) "Long Odds: Longitudinal Development of…

Writing Our Way: Giving Voice to Adult Learning. Adult Higher Education Alliance Annual Conference Proceedings (41st, Orlando, Florida, March 9-10, 2017)

ERIC Educational Resources Information Center

Elufiede, Kemi, Ed.; Flynn, Bonnie, Ed.; Olson, Joann S., Ed.

2017-01-01

The 41st annual conference of the Adult and Higher Education Alliance (AHEA) was held at the University of Central Florida in March 2017 and explored the theme, "Writing Our Way: Giving Voice to Adult Learning." Papers in these proceedings include: (1) Transformative Learning Following Job Loss-A Dissertation Renewal (Robert Benway); (2)…

Surveillance of healthcare associated infections in pediatric cancer patients between 2004 and 2009 in a public pediatric hospital in Mexico city, Mexico.

PubMed

Hernández Orozco, Hilda; Lucas Resendiz, Esperanza; Castañeda, Jose Luis; De Colsa, Agustin; Ramirez Mayans, Jaime; Johnson, Kyle M; Gonzalez, Napoleon; Caniza, Miguela A

2014-03-01

Pediatric oncology and hematology patients are at increased risk of developing healthcare associated infections (HAIs). We conducted a prospective surveillance study on children with cancer admitted to the pediatric hematology and oncology units at a public pediatric hospital in Mexico from January 2004 to December 2009. The incidence of HAIs and groups at greatest risk for HAIs were analyzed. The annual HAI incidence rate and incidence density were calculated. Risk factors such as site of infection, HAI types, and cancer diagnosis were studied. A total of 9420 patients participated, and 409 had HAIs (479 episodes). Annual HAI rates were 3.7 to 5.5 per 100 admissions and the incidence density was 5.75 to 6 HAIs per 1000 inpatient days annually. There were 272 (56.8%) bloodstream infections, 45 (9.4%) pneumonia cases, and 44 (9.2%) skin and soft tissue infections. Children with acute lymphoblastic leukemia had 37.2% and those with acute myeloid leukemia had 16.4% of the HAIs. A total of 11.5% of the HAIs were in children with osteosarcoma. The most common pathogens were Gram-negative bacteria. The HAI-associated mortality rate was 3.7%. Although the overall HAI rate is in line with published reports, the mortality rate was higher, suggesting the incorporation of more aggressive methods to treat infections at our hospital.

77 FR 8846 - Notice of Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

..., Evaluation and Policy Development Type of Review: New. Title of Collection: 21st Century Community Learning Centers: Lessons Learned Guides. OMB Control Number: Pending. Total Estimated Number of Annual Responses... guides for the 21st Century Community Learning Centers (21st CCLC) program that will assist the U.S...

Detection of conveyance changes in St. Clair River using historical water-level and flow data with inverse one-dimensional hydrodynamic modeling

USGS Publications Warehouse

Holtschlag, David J.; Hoard, C.J.

2009-01-01

St. Clair River is a connecting channel that transports water from Lake Huron to the St. Clair River Delta and Lake St. Clair. A negative trend has been detected in differences between water levels on Lake Huron and Lake St. Clair. This trend may indicate a combination of flow and conveyance changes within St. Clair River. To identify where conveyance change may be taking place, eight water-level gaging stations along St. Clair River were selected to delimit seven reaches. Positive trends in water-level fall were detected in two reaches, and negative trends were detected in two other reaches. The presence of both positive and negative trends in water-level fall indicates that changes in conveyance are likely occurring among some reaches because all reaches transmit essentially the same flow. Annual water-level fall in reaches and reach lengths was used to compute conveyance ratios for all pairs of reaches by use of water-level data from 1962 to 2007. Positive and negative trends in conveyance ratios indicate that relative conveyance is changing among some reaches. Inverse one-dimensional (1-D) hydrodynamic modeling was used to estimate a partial annual series of effective channel-roughness parameters in reaches forming the St. Clair River for 21 years when flow measurements were sufficient to support parameter estimation. Monotonic, persistent but non-monotonic, and irregular changes in estimated effective channel roughness with time were interpreted as systematic changes in conveyances in five reaches. Time-varying parameter estimates were used to simulate flow throughout the St. Clair River and compute changes in conveyance with time. Based on the partial annual series of parameters, conveyance in the St. Clair River increased about 10 percent from 1962 to 2002. Conveyance decreased, however, about 4.1 percent from 2003 to 2007, so that conveyance was about 5.9 percent higher in 2007 than in 1962.

Teaching of Psychology: Ideas and Innovations. Proceedings of the Annual Conference on Undergraduate Teaching of Psychology (21st, Kerhonkson, New York, March 28-30, 2007)

ERIC Educational Resources Information Center

Zaromatidis, Katherine, Ed.; Oswald, Patricia A., Ed.; Levine, Judith R., Ed.; Indenbaum, Gene, Ed.

2007-01-01

The 21st Annual Conference on Undergraduate Teaching of Psychology was held on March 28-30, 2007 at Hudson Valley Resort and Day Spa in Kerhonkson, New York. The conference was sponsored by the Psychology Department of Farmingdale State College. The conference included twenty five presentations and ten of these are included in these proceedings.…

Title I in Ohio, Including Title I, Migrant, State Neglected or Delinquent, Title VI, Homeless Children and Youth. Elementary and Secondary Education Act: 31st Annual Evaluation Report, Fiscal Year 1996.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Federal Assistance.

The first section in this 31st annual report summarizes activities provided in Ohio through Title I of the Elementary and Secondary Education Act during fiscal year 1996. Title I authorizes federally funded programs that prioritize educational needs of several groups of educationally disadvantaged children and deliver appropriate supplemental…

Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.

PubMed

Karam, Louna; Houshaymi, Bilal; Abdel-Samad, Rana; Jaafar, Mariam; Halloum, Iman; Pisano, Claudio; Neipel, Frank; Darwiche, Nadine; Abou Merhi, Raghida

2018-02-01

Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer mutations; however, their oncogenesis is mainly attributed to HHV-8 latent genes. Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy. ST1926 is a synthetic retinoid with favorable antitumor properties and no cross-resistance with the natural retinoid, all-trans retinoic acid. ST1926 has shown potent apoptotic activities on a variety of solid tumors and hematologic malignancies in in vitro and in vivo models. In the present study we elucidated the antitumor activities and underlying molecular mechanism of ST1926 using in vitro, ex vivo, and in vivo PEL preclinical models. ST1926, at sub‑micromolar concentrations, displayed potent antiproliferative effects on PEL cell lines and malignant ascites. Furthermore, ST1926 treatment of PEL cells and ascites resulted in their accumulation in the sub-G1 region, S phase cell cycle arrest, early DNA damage, PARP cleavage and p53 activation including the upregulation of its target genes p21 and Bax. However, ST1926 did not significantly modulate HHV-8 latent viral transcripts. Importantly, ST1926 delayed formation of ascites and enhanced survival of PEL mice. These results highlight the therapeutic potential of ST1926 in combination with drugs that target HHV-8 in PEL patients.

Ambulatory Care Data Base (ACDB) Data Dictionary Sequential Files of Phase 1

DTIC Science & Technology

1989-11-01

STIMULATION AND EXERCISE 07000 EXAM MICROSCOPIC (ARTHROPOD) 07001 SCREENING, SICKLE CELL 07002 SCREENING, RUBELLA 07003 EXAM, PHYSICAL , (CHN) 07004...DIATHERMY 97028 PHYSICAL MEDICINE TREATMENT, ULTRAVIOLET 97116 GAIT TRAINING 97118 ELECTRICAL STIMULATION , MANUAL 97120 IONTOPHORESIS 97124 PHYSICAL ...Hematology 50 ENT 71 Pain/ Physical Med. 51 Occupational Ther. 72 Plastic Surgery 52 Ophthamology/Op 73 Preventive Med/CHN 53 Physical Ther, 74 General

Distribution of Suicin Gene Clusters in Streptococcus suis Serotype 2 Belonging to Sequence Types 25 and 28.

PubMed

Athey, Taryn B T; Vaillancourt, Katy; Frenette, Michel; Fittipaldi, Nahuel; Gottschalk, Marcelo; Grenier, Daniel

2016-01-01

Recently, we reported the purification and characterization of three distinct lantibiotics (named suicin 90-1330, suicin 3908, and suicin 65) produced by Streptococcus suis . In this study, we investigated the distribution of the three suicin lantibiotic gene clusters among serotype 2 S. suis strains belonging to sequence type (ST) 25 and ST28, the two dominant STs identified in North America. The genomes of 102 strains were interrogated for the presence of suicin gene clusters encoding suicins 90-1330, 3908, and 65. The gene cluster encoding suicin 65 was the most prevalent and mainly found among ST25 strains. In contrast, none of the genes related to suicin 90-1330 production were identified in 51 ST25 strains nor in 35/51 ST28 strains. However, the complete suicin 90-1330 gene cluster was found in ten ST28 strains, although some genes in the cluster were truncated in three of these isolates. The vast majority (101/102) of S. suis strains did not possess any of the genes encoding suicin 3908. In conclusion, this study indicates heterogeneous distribution of suicin genes in S. suis .

Iron supplementation prevents a decline in iron stores and enhances strength performance in elite female volleyball players during the competitive season.

PubMed

Mielgo-Ayuso, Juan; Zourdos, Michael C; Calleja-González, Julio; Urdampilleta, Aritz; Ostojic, Sergej

2015-06-01

The primary aim of this study was to examine the effects of 11 weeks of iron supplementation on hematological and strength markers in elite female volleyball players. Twenty-two volleyball players (aged 27.0 ± 5.6 years) from 2 Spanish First National League teams participated and were counterbalanced into 1 of 2 groups based upon iron status: (i) control group (CG, n = 11); or (ii) iron treatment group (ITG, n = 11), which received 325 mg/day of ferrous sulphate daily. Subjects performed their team's regimen of training or match play every day. Both groups were tested for hematological and strength levels at 2 points: (i) baseline (T0, before preseason) and (ii) 11 weeks later (T11, post-testing). Hematological parameters were serum iron (sFe), serum ferritin (FER), transferrin saturation index (TSI), and hemoglobin (Hb); strength assessments were bench press, military press, half-squat, power clean, clean and jerk, and pull-over. CG experienced a significant decrease (p < 0.05) for sFe (T0, 112.7 ± 31.5; T11, 69.0 ± 20.5 μg·dL(-1); -33.9%), FER (T0, 60.2 ± 28.6; T11, 38.2 ± 16.4 ng·mL(-1); -34.6%), TSI (T0, 29.4% ± 9.5%; T11, 17.4% ± 5.1%; -35.3%), and Hb (T0, 14.1 ± 1.0; T11, 13.0 ± 0.8 g·L(-1); -7.44%); however, ITG experienced no changes (p > 0.05). Consequently, in ITG all hematological parameters were significantly greater (p < 0.05) than CG at T11. There was greater (p < 0.05) percent increase in the clean and jerk (CG: +5.1% ± 20.9 vs. ITG: +29.0% ± 21.3%), power clean (CG: -5.8% ± 30.3% vs. ITG: +44.6% ± 56.6%), and total mean strength (CG: +10.9% ± 3.2% vs. ITG: +26.2% ± 3.6%) in ITG. Our findings suggest that oral iron supplementation prevents iron loss and enhances strength in female volleyball players during the competitive season.

Stroke in Saudi children. Epidemiology, clinical features and risk factors.

PubMed

Salih, Mustafa A; Abdel-Gader, Abdel-Galil M; Al-Jarallah, Ahmed A; Kentab, Amal Y; Alorainy, Ibrahim A; Hassan, Hamdy H; Bahakim, Hassan M; Kurbaan, Khadija M; Zahraa, Jihad N; Al-Nasser, Mohammed N; Nasir, Ali A; Khoja, Waleed A; Kabiraj, Mohammad M

2006-03-01

To describe the epidemiology and clinical features of stroke in a prospective and retrospective cohort of Saudi children and ascertain the causes, pathogenesis, and risk factors. The Retrospective Study Group (RSG) included children with stroke who were evaluated at the Division of Pediatric Neurology, or admitted to King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia during the period July 1992 to February 2001. The Prospective Study Group (PSG) included those seen between February 2001 and March 2003. During the combined study periods of 10 years and 7 months, 117 children (61 males and 56 females, aged one month-12 years) were evaluated; the majority (89%) of these were Saudis. The calculated annual hospital frequency rate of stroke was 27.1/100,000 of the pediatric (1 month-12 years) population. The mean age at onset of the initial stroke in the 104 Saudi children was 27.1 months (SD = 39.3 months) and median was 6 months. Ischemic strokes accounted for the majority of cases (76%). Large-vessel infarcts (LVI, 51.9%) were more common than small-vessel lacunar lesions (SVLL, 19.2%). Five patients (4.8%) had combined LVI and SVLL. Intracranial hemorrhage was less common (18.2%), whereas sinovenous thrombosis was diagnosed in 6 (5.8%) patients. A major risk factor was identified in 94 of 104 (89.4%) Saudi children. Significantly more hematologic disorders and coagulopathies were identified in the PSG compared to the RSG (p=0.001), reflecting a better yield following introduction of more comprehensive hematologic and coagulation laboratory tests during the prospective study period. Hematologic disorders were the most common risk factor (46.2%), presumed perinatal ischemic cerebral injury was a risk factor in 23 children (22.1%) and infectious and inflammatory disorders of the circulatory system in 18 (17.3%). Congenital and genetic cerebrovascular anomalies were the underlying cause in 7 patients (6.7%) and cardiac diseases in 6 (5.8%). Six patients (5.8%) had moyamoya syndrome, which was associated with another disease in all of them. Inherited metabolic disorders (3.8%) included 3 children with Leigh syndrome and a 29-month-old girl with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. Systemic vascular disease was a risk factor in 3 children (2.9%) including 2 who had hypernatremic dehydration; and post-traumatic arterial dissection was causative in 3 cases (2.9%). Several patients had multiple risk factors, whereas no risk factor could be identified in 11 (10.6%). Due to the high prevalence and importance of multiple risk factors, a comprehensive investigation, including hematologic, neuroimaging and metabolic studies should be considered in every child with stroke.

6. (First sheet of a twosheet set entitled 'Kongensgade 5154') ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. (First sheet of a two-sheet set entitled 'Kongensgade 51-54') KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 51, 52 & 53 (only part of Kongensgade 53 elevation shown, for full elevation overlap with complementary photograph VI-50-7) (LEFT TO RIGHT) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

Hematopoietic Stem Cell Transplantation in India-2017 Annual Update.

PubMed

Naithani, Rahul

2018-01-01

There has been a steady rise in number of transplant centers in India over last few years. This year many papers related to bone marrow transplants were presented in annual conference of Indian society of Hematology and Transfusion Medicine. All oral and poster presentations which were published were reviewed. There were many publications on autologous transplant, allogeneic transplant and lab aspects of transplant. Centers shared their data on autologous transplants in newly set-up units with resource constraints with good outcomes. Encouraging data from across India is likely to boost more centers to set up transplant centers.

Annual variation of hematology and plasma chemistry in shortnose sturgeon, Acipenser brevirostrum, during a dam-impeded spawning run.

PubMed

Matsche, Mark A; Gibbons, Jarrett

2012-12-01

Shortnose sturgeon (Acipenser brevirostrum) spawning migrations on the Cooper River are impeded by Pinopolis Dam, Lake Moultrie, South Carolina. Sturgeon and other species aggregate below the dam in late winter/early spring and are subjected to a variety of stressors stemming from crowding, poor habitat quality, and injuries that appear to be caused by boat propeller or turbine strikes. Spawning has been documented in the tailrace, but reproductive success has not been verified as no juveniles have been captured. Fish within the dam tailrace were captured by gill net during winter, 2005 and 2007-2011, and physiological condition was assessed using a panel of hematologic and biochemical indices. Plasma phosphorus and calcium were significantly higher in females, while PCV and aspartate aminotransferase were significantly higher in males, indicating sex-specific physiological changes triggered during maturity. A marked leucopenia, accompanied by lymphopenia and neutrophilia, was evident in both sexes and was consistent across years, indicating that these fish were under chronic stress. Testosterone and estradiol levels and hematologic and biochemical reference intervals are provided for comparative purposes.

Laboratory hematology in the history of Clinical Chemistry and Laboratory Medicine.

PubMed

Hoffmann, Johannes J M L

2013-01-01

For the occasion of the 50th anniversary of the journal Clinical Chemistry and Laboratory Medicine (CCLM), an historic overview of papers that the journal has published in the field of laboratory hematology (LH) is presented. All past volumes of CCLM were screened for papers on LH and these were categorized. Bibliographic data of these papers were also analyzed. CCLM published in total 387 LH papers. The absolute number of LH papers published annually showed a significant increase over the years since 1985. Also the share of LH papers demonstrated a steady increase (overall mean 5%, but mean 8% over the past 4 years). The most frequent category was coagulation and fibrinolysis (23.5%). Authors from Germany contributed the most LH papers to the journal (22.7%), followed by the Netherlands and Italy (16.3 and 13.2%, respectively). Recent citation data indicated that other publications cited LH review papers much more frequently than other types of papers. The history of the journal reflects the emergence and development of laboratory hematology as a separate discipline of laboratory medicine.

Emerging antibody-drug conjugates for treating lymphoid malignancies.

PubMed

Wolska-Washer, Anna; Robak, Pawel; Smolewski, Piotr; Robak, Tadeusz

2017-09-01

Antibody-drug conjugates (ADC) are monoclonal antibodies (Mabs) attached to biologically active drugs through specialized chemical linkers. They deliver and release cytotoxic agents at the tumor site, reducing the likelihood of systemic exposure and therefore toxicity. These agents should improve the potency of chemotherapy by increasing the accumulation of cytotoxic the drug within or near the neoplastic cells with reduced systemic effects. Areas covered: A literature review was conducted of the MEDLINE database PubMed for articles in English examining Mabs, B-cell receptor pathway inhibitors and immunomodulating drugs. Publications from 2000 through April 2017 were scrutinized. Conference proceedings from the previous five years of the American Society of Hematology, European Hematology Association, American Society of Clinical Oncology, and ACR/ARHP Annual Scientific Meetings were searched manually. Additional relevant publications were obtained by reviewing the references from the chosen articles. Expert opinion: Newer ADCs show promise as treatment for several hematologic malignancies, especially lymphoma, multiple myeloma, and leukemia. However, definitive data from ongoing and future clinical trials will aid in better defining the status of these agents in the treatment of these diseases.

Navigating Currents and Charting Directions. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia (31st, Brisbane, Queensland, Australia, June 28-July 1, 2008). Volumes 1 and 2

ERIC Educational Resources Information Center

Goos, Merrilyn, Ed.; Brown, Ray, Ed.; Makar, Katie, Ed.

2008-01-01

This document presents the proceedings of the 31st Annual Conference of the Mathematics Education Research Group of Australasia (MERGA). The theme of this conference is "Navigating Currents and Charting Directions." The theme reminds us that, although we are constantly pushed to account for the quality and impact of our research, we…

4. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 1013 (LEFT TO RIGHT) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 10-13 (LEFT TO RIGHT) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

Post-challenge hematological evaluation with virulent strain of Eimeria tenella in broilers immunized with attenuated strain or sporozoite proteins from homologous strain.

PubMed

Bogado, Alexey Leon Gomel; Garcia, João Luis; Silva, Patrícia Fernandes Nunes da; Balarin, Mara Regina Stipp; Junior, José da Silva Guimarães

2010-01-01

Hematological parameters were evaluated in broilers immunized and challenged with Eimeria tenella. Broiler chickens of Hubbard strain, females, coccidian-free, were kept in wire cages and inoculated on the third day. The experiment was designed to include five sorts of treatment with three replicates each. T1 was the negative control group, T2 received 500 attenuated sporulated oocysts by gavage, T3 was the positive control, T4 received 50 μg of sporozoite protein + Quil A vaccine, and T5 received Quil A without sporozoite protein + PBS, the last two through nasal route on days 0, 7, and 21. On the 31st day, all treatments were challenged with homologous virulent strain of E. tenella in the dose of 8.0 x 10⁴ oocysts, with the exception of T1. One week later, blood sampling, lesion scores, and cecal oocyst count were carried out. The parasitological parameters showed statistical significance (p < 0.05) and there was no damage to the hematological parameters of birds (p > 0.05) by ANOVA test. The correlations suggest that the blood parameters were impaired by effects of the parasite on tissue, showing levels of hemorrhage and/or hydration.

Hematological, oxidative stress, and immune status profiling in elite combat sport athletes.

PubMed

Dopsaj, Violeta; Martinovic, Jelena; Dopsaj, Milivoj; Kasum, Goran; Kotur-Stevuljevic, Jelena; Koropanovski, Nenad

2013-12-01

The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured parameters. Eighteen karate professionals, 15 wrestlers, and 14 kickboxers participated in the study. Hematological, iron-related, oxidative stress, and immunological parameters were measured at the beginning of a precompetitive period. The general linear model showed significant differences between the karate professionals, wrestlers, and kickboxers with respect to their hematological and iron status parameters (Wilks' Lambda = 0.270, F = 2.186, p < 0.05) and oxidative stress status (Wilks' Lambda = 0.529, F = 1.940, p < 0.05). The immature reticulocyte fraction was significantly higher in wrestlers (0.30 ± 0.03) compared with kickboxers (0.24 ± 0.04; p < 0.05) and karate professionals (0.26 ± 0.04; p < 0.05). Low hemoglobin density was significantly lower in wrestlers and kickboxers (p < 0.05) compared with karate professionals (karate: 3.51 ± 1.19, wrestlers: 1.95 ± 1.10, and kickboxers: 1.77 ± 0.76). Significant differences were observed between the karate professionals and wrestlers with respect to their pro-oxidant-antioxidant balance (437 ± 103 vs. 323 ± 148, p < 0.05) and superoxide-dismutase activity (SOD) (73 ± 37 vs. 103 ± 30, p < 0.05). All the measured parameters (with the exception of SOD activity) fell within their physiological ranges, indicating that the study participants represented a young and healthy male population. Hematological parameters differed between kickboxers and karate professionals. The low pro-oxidant-antioxidant balance and high SOD activity in wrestlers could be associated with the long-term impact of wrestling as a type of strenuous exercise.

Ionizing radiation exposures in treatments of solid neoplasms are not associated with subsequent increased risks of chronic lymphocytic leukemia.

PubMed

Radivoyevitch, Tomas; Sachs, Rainer K; Gale, Robert Peter; Smith, Mitchell R; Hill, Brian T

2016-04-01

Exposure to ionizing radiation is not thought to cause chronic lymphocytic leukemia (CLL). Challenging this notion are recent data suggesting CLL incidence may be increased by radiation exposure from the atomic bombs (after many decades), uranium mining and nuclear power facility accidents. To assess the effects of therapeutic ionizing radiation for the treatment of solid neoplasms we studied CLL risks in data from the Surveillance, Epidemiology, and End Results (SEER) Program. Specifically, we compared the risks of developing CLL in persons with a 1(st) non-hematologic cancer treated with or without ionizing radiation. We controlled for early detection effects on CLL risk induced by surveillance after 1(st) cancer diagnoses by forming all-time cumulative CLL relative risks (RR). We estimate such CLL RR to be 1.20 (95% confidence interval, 1.17, 1.23) for persons whose 1(st) cancer was not treated with ionizing radiation and 1.00 (0.96, 1.05) for persons whose 1(st) cancer was treated with ionizing radiations. These results imply that diagnosis of a solid neoplasm is associated with an increased risk of developing CLL only in persons whose 1(st) cancer was not treated with radiation therapy. Copyright © 2016 Elsevier Ltd. All rights reserved.

Hematologic and Selected Hepatic Changes Produced by Substituted p-Bensoquinones in the Rat.

DTIC Science & Technology

1980-07-01

DIVISION OF NUTRITION TECHNOLOGY *DIVISION OF CUTANEOUS HAZARDS I LEECE D IBAI7 TA EMENl AU I __ b rouleISO, Ca. JULYV 1980 CD, LA. 9=3TIRMAN ARMY...jaundice, anemia, hemoglobinuria, and cachexia (8). In previous studies, we found that benzoquinone tox- icity in rats resulted in respiratory depression...randomly housed in stainless steel wire-bottomed cages, one to a cage, and fed a stock diet (Rodent Laboratory Chow #5001, Ralston Purina Co., St. Louis

First Description of KPC-2-Producing Escherichia coli and ST15 OXA-48-Positive Klebsiella pneumoniae in Tunisia.

PubMed

Ben Tanfous, Farah; Alonso, Carla Andrea; Achour, Wafa; Ruiz-Ripa, Laura; Torres, Carmen; Ben Hassen, Assia

2017-04-01

The aim of this study was to investigate the molecular features among Klebsiella pneumoniae and Escherichia coli strains showing a resistant/intermediate-resistant phenotype to ertapenem (R/IR-ERT), implicated in colonization/infection in patients of the Hematology and Graft Units of the National Bone Marrow Transplant Center of Tunisia (3-year period, 2011-2014). The major carbapenemase, extended-spectrum beta-lactamase, and plasmidic AmpC beta-lactamase genes were analyzed and characterized by PCR and sequencing. Genetic relatedness was determined by pulsed-field gel electrophoresis (PFGE) using XbaI and multilocus sequencing typing. The bla OXA-48 and bla KPC carbapenemase genes were detected among R/IR-ERT isolates. All R/IR-ERT K. pneumoniae strains (n = 19) had bla OXA-48 gene, and 14/19 strains also harbored the bla CTX-M-15 gene. Eight different PFGE patterns were detected among these K. pneumoniae isolates, and they showed eight different sequences types, ST11 and ST15 being the most prevalent ones. Two out of three R/IR-ERT E. coli isolates carried bla OXA-48 and one coproduced the bla CTX-M-15 gene. One E. coli strain, ascribed to the new sequence type ST5700, harbored the bla KPC-2 gene. E. coli isolates were not clonally related and belonged to different sequence types (ST5700, ST227, and ST58). To our knowledge, this is the first report in Tunisia of either KPC-2 carbapenemase in E. coli or OXA-48 carbapenemase in K. pneumoniae of lineage ST15.

51. East tile gauge on south pier. Each square tile ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. East tile gauge on south pier. Each square tile is 4' in size. Lower end of cross second from bottom - Duluth Ship Canal, South Pier, North end of Minnesota Point & Canal Park, Duluth, St. Louis County, MN

Effect of chronic ingestion of lead on gastrointestinal transit in rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walsh, C.T.; Ryden, E.B.

1984-09-30

GI symptoms such as constipation and abdominal colic are signs of lead poisoning in man, but mechanisms of these effects have not been elucidated. To evaluate GI transit, male Wistar rats were dosed with 1% lead or 0.7% sodium acetate in their diet (AIN-76A). After 7 weeks, lead-treated animals exhibited decreased hematocrit, increased 24-hr urinary excretion of delta-ALA, increased kidney/body weight ratio, and decreased body weight. Blood-lead concentrations were elevated to 196 +/- 57 micrograms/dl. Lead treatment, however, did not result in change in GI transit of a nonabsorbable marker, 51Cr, 15 min or 6 hr after po administration. Theremore » was also no change in fecal percentage water content. Since in control animals the semipurified diet AIN-76A markedly decreased fecal excretion rate of 51Cr compared to a cereal-based diet, NIH-07, the latter was used in subsequent experiments. Rats fed 2 or 4% lead acetate in NIH-07 for 8 weeks exhibited renal and hematologic toxicity as in the initial experiment. Weight gain was impaired in the 4% group compared to pair-fed controls. No significant differences were observed in the 1-hr gastric emptying or the fecal excretion of 51Cr in the 2 or 4% lead-treated animals, although there was a trend for slower transit in rats receiving the higher dose. These observations indicate that concentrations of lead sufficient to induce renal and hematologic toxicity in rats do not substantially affect GI transit.« less

Predicting nonstationary flood frequencies: Evidence supports an updated stationarity thesis in the United States

NASA Astrophysics Data System (ADS)

Luke, Adam; Vrugt, Jasper A.; AghaKouchak, Amir; Matthew, Richard; Sanders, Brett F.

2017-07-01

Nonstationary extreme value analysis (NEVA) can improve the statistical representation of observed flood peak distributions compared to stationary (ST) analysis, but management of flood risk relies on predictions of out-of-sample distributions for which NEVA has not been comprehensively evaluated. In this study, we apply split-sample testing to 1250 annual maximum discharge records in the United States and compare the predictive capabilities of NEVA relative to ST extreme value analysis using a log-Pearson Type III (LPIII) distribution. The parameters of the LPIII distribution in the ST and nonstationary (NS) models are estimated from the first half of each record using Bayesian inference. The second half of each record is reserved to evaluate the predictions under the ST and NS models. The NS model is applied for prediction by (1) extrapolating the trend of the NS model parameters throughout the evaluation period and (2) using the NS model parameter values at the end of the fitting period to predict with an updated ST model (uST). Our analysis shows that the ST predictions are preferred, overall. NS model parameter extrapolation is rarely preferred. However, if fitting period discharges are influenced by physical changes in the watershed, for example from anthropogenic activity, the uST model is strongly preferred relative to ST and NS predictions. The uST model is therefore recommended for evaluation of current flood risk in watersheds that have undergone physical changes. Supporting information includes a MATLAB® program that estimates the (ST/NS/uST) LPIII parameters from annual peak discharge data through Bayesian inference.

Analysis of the Use and Impact of Twitter During American Society of Clinical Oncology Annual Meetings From 2011 to 2016: Focus on Advanced Metrics and User Trends.

PubMed

Pemmaraju, Naveen; Thompson, Michael A; Mesa, Ruben A; Desai, Tejas

2017-07-01

The use of social media, in particular Twitter, has substantially increased among health care stakeholders in the field of hematology and oncology, with an especially sharp increase in the use of Twitter during times of major national meetings. The most attended meeting in the oncology field is the ASCO annual meeting. Little is known about the detailed metrics involved in the use, volume, and impact of Twitter during the ASCO annual meeting. We conducted a retrospective review of tweets during the ASCO annual meetings from 2011 to 2016. The total data set encompassed 190,732 tweets from 39,745 authors over six consecutive ASCO meetings from 2011 to 2016 (inclusive). Tweets, all publically available, were collected by Nephrology On-Demand Analytics. The number of individual authors increased from 1,429 during the 2011 ASCO meeting to 15,796 during the 2016 ASCO meeting, an 11-fold increase over the total 5-year period. There was a notable increase in tweets from the 2011 ASCO meeting (n = 7,746) to the 2016 ASCO meeting (n = 72,698), a nine-fold increase during the study period. The most commonly tweeted term or topic changed over time, generally reflecting the breakthroughs of each designated year; these terms were "melanoma" for both the 2011 and 2012 ASCO meetings; "breast cancer" for the 2013 ASCO meeting; "lung cancer" for the 2014 ASCO meeting; and "ImmunOnc" or "immunotherapy/immuno-oncology" for both the 2015 and 2016 ASCO meetings. The use of Twitter among health care stakeholders during the ASCO meeting has markedly increased over time, demonstrating the increasing role of social media in the dissemination of findings at the most highly attended hematology and oncology conference of the year.

Annual Science and Technology Report to the Congress: 1982.

ERIC Educational Resources Information Center

Office of Science and Technology Policy, Washington, DC.

This report provides a comprehensive statement of the Reagan administration's science and technology (S/T) policy and priorities. The report is organized into three chapters. Chapter I discusses S/T and United States society and the United States S/T policy. Highlights of the 1982 accomplishments in implementing the policy and of the fiscal year…

Joint analysis of air pollution in street canyons in St. Petersburg and Copenhagen

NASA Astrophysics Data System (ADS)

Genikhovich, E. L.; Ziv, A. D.; Iakovleva, E. A.; Palmgren, F.; Berkowicz, R.

The bi-annual data set of concentrations of several traffic-related air pollutants, measured continuously in street canyons in St. Petersburg and Copenhagen, is analysed jointly using different statistical techniques. Annual mean concentrations of NO 2, NO x and, especially, benzene are found systematically higher in St. Petersburg than in Copenhagen but for ozone the situation is opposite. In both cities probability distribution functions (PDFs) of concentrations and their daily or weekly extrema are fitted with the Weibull and double exponential distributions, respectively. Sample estimates of bi-variate distributions of concentrations, concentration roses, and probabilities of concentration of one pollutant being extreme given that another one reaches its extremum are presented in this paper as well as auto- and co-spectra. It is demonstrated that there is a reasonably high correlation between seasonally averaged concentrations of pollutants in St. Petersburg and Copenhagen.

Survival From Childhood Hematological Malignancies in Denmark: Is Survival Related to Family Characteristics?

PubMed

Erdmann, Friederike; Winther, Jeanette Falck; Dalton, Susanne Oksbjerg; Lightfoot, Tracy; Zeeb, Hajo; Simony, Sofie Bay; Deltour, Isabelle; Ferro, Gilles; Bautz, Andrea; Schmiegelow, Kjeld; Schüz, Joachim

2016-06-01

Due to diverse findings as to the role of family factors for childhood cancer survival even within Europe, we explored a nationwide, register-based cohort of Danish children with hematological malignancies. All children born between 1973 and 2006 and diagnosed with a hematological malignancy before the age of 20 years (N = 1,819) were followed until 10 years from diagnosis. Kaplan-Meier curves and Cox proportional hazards models estimating hazard ratios (HR) and 95% confidence intervals (CI) were used to assess the impact of family characteristics on overall survival in children with hematological malignancies. Having siblings and increasing birth order were associated with reduced survival from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Associations with AML were strongest and statistically significant. HRs of 1.62 (CI 0.85; 3.09) and 5.76 (CI 2.01; 16.51) were observed for the fourth or later born children with ALL (N = 41) and AML (N = 9), respectively. Children with older parents showed a tendency toward inferior ALL survival, while for AML young maternal age was related to poorer survival. Based on small numbers, a trend toward poorer survival from non-Hodgkin lymphoma was observed for children having siblings and for children of younger parents. Further research is warranted to gain further knowledge on the impact of family factors on childhood cancer survival in other populations and to elaborate potential underlying mechanisms and pathways of those survival inequalities. © 2016 Wiley Periodicals, Inc.

Hematological alterations and thymic function in newborns of HIV-infected mothers receiving antiretroviral drugs.

PubMed

Wongnoi, Rotjanee; Penvieng, Nawaporn; Singboottra, Panthong; Kingkeow, Doungnapa; Oberdorfer, Peninnah; Sirivatanapa, Pannee; Pornprasert, Sakorn

2013-06-08

To investigate the effects of antiretroviral (ARV) drugs on hematological parameters and thymic function in HIV-uninfected newborns of HIV-infected mothers. Cross sectional study. Chiang-Mai University Hospital, Chiang-Mai, Thailand. 49 HIV-uninfected and 26 HIV-infected pregnancies. Cord blood samples of newborns from HIV-uninfected and HIV-infected mothers were collected. Hematological parameters were measured using automatic blood cell count. T-cell receptor excision circles (TRECs) levels in cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells were quantified using real-time PCR.. Hemotological parameters and thymic function. Newborn of HIV-infected mother tended to have lower mean levels of hemoglobin than those of HIV-uninfected mother (137 ±22 vs 146 ±17 g/L, P = 0.05). Furthermore, mean of red blood cell (RBC) counts and hematocrit and median of TRECs in CD4+ T-cells in the newborns of the former were significantly lower than those of the latter [3.6 ±0.7 vs 4.8 ±0.6 x 1012 cells/L, P <0.001; 0.40 ±0.07 vs 0.46 ±0.05 L/L, P < 0.001 and 0.53 (IQR: 0.03-5.76) vs 13.20 (IQR: 2.77-27.51) x 10-3 pg/uL, P = 0.02, respectively]. ARV drugs altered hematological parameters and thymic function (TRECs CD4+ T-cells) in HIV-uninfected newborns of HIV-infected mothers.

Optical investigation of variability in body region dependent transcutaneous oxygen saturation

NASA Astrophysics Data System (ADS)

Philimon, Sheena P.; Huong, Audrey K. C.; Hafizah, W. M.; Ong, P. E.; Ngu, Xavier T. I.

2016-11-01

This paper presents the use of multispectral imaging system to investigate variability in transcutaneous oxygen saturation (StO2) amongst different individuals and at different skin sites. Noncontact reflectance data are collected from central forehead, posterior forearm, thenar region of palm and proximal ankle of three healthy Asians. The prediction of the required StO2 value is via fitting Extended Modified Lambert (EMLB) model to the measured attenuation data using extinction coefficient of hemoglobin components in the wavelength range of 520 - 600 nm as its priori knowledge. The obtained results revealed a relatively high mean StO2 of 54 ± 1.9% at the palm of the hand site. This is followed by measurement at foot ankle and forehead with StO2 of 52.3 ± 2.4% and 51.2 ± 7.7%, respectively. Meanwhile the lowest reading of StO2 of 48.8 ± 5.1% is observed at the posterior forearm. Based on these findings, this work concluded that palm of the hand would provide considerably consistent measurement of StO2 among individuals. This is largely owing to the higher density of circulatory anastomosis at this skin site. This implied viability of using the developed strategy in the studies of microcirculation mechanism especially on wound at this skin region.

Near-infrared interactance (NIR): a new non-invasive technique to estimate subcutaneous body fat in newborns.

PubMed

Demarini, S; Donnelly, M M

1994-01-01

Body fat (BF) is rarely determined routinely in infants due to the lack of a simple measuring device. A portable NIR instrument, successfully applied in adults, takes 5 seconds for a measurement and involves no skin manipulation. We designed this study 1) to compare BF estimates by NIR to skinfold thickness (ST) and 2) to assess the relationship of NIR and ST values with standard measures reflecting BF, such as Weight/Length Ratio, Body Mass Index and Ponderal Index. We studied BF in 40 healthy term infants within 12 hours of birth by NIR and ST at 3 standard sites: triceps (TRI), subscapular (SUB) and abdominal (ABD). RESULTS. Significant correlations were found between NIR and ST (R=0.70, 0.58 and 0.64 for SUB, TRI and ABD, respectively); between the sums of the 3 measurements (R= 0.69), and between birthweight and ST (R=0.57) or NIR (0.51), and between Weight/Length Ratio and ST (R=0.55) or NIR (R=0.51). We conclude that NIR measurements correlate well with skinfold measurements and NIR can be measured faster than skinfolds (5 vs 60 seconds). We speculate that NIR could be cost-effective for routine clinical measure of body fat and growth in infants.

150-211 E. Illinois St and 450-51 N St. Clair Streets, February 2018, Lindsay Light Radiological Survey

EPA Pesticide Factsheets

The field gamma measurements within the excavation during the excavation process did not exceed the instrument threshold previously stated and ranged from a minimum of 1,100 cpm to a maximum of 2,100cpm shielded.

LOW DOSE PESTICIDE EXPOSURE AND ALTERED REPRODUCTIVE SYSTEM DEVELOPMENT IN REPTILES

EPA Science Inventory

In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, Nashville, TN. Society of Environmental Toxicology and Chemistry, Pensacola, FL. Pp. 99.

INTER-SPECIES STEROID RECEPTOR EXTRAPOLATION STUDIES FOR ENDOCRINE DISRUPTING CHEMICALS

EPA Science Inventory

In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, Nashville, TN. Society of Environmental Toxicology and Chemistry, Pensacola, FL. Pp. 117-118.

Absence of CTX-M Enzymes but High Prevalence of Clones, Including Clone ST131, among Fecal Escherichia coli Isolates from Healthy Subjects Living in the Area of Paris, France▿

PubMed Central

Leflon-Guibout, Véronique; Blanco, Jorge; Amaqdouf, Karim; Mora, Azucena; Guize, Louis; Nicolas-Chanoine, Marie-Hélène

2008-01-01

Quinolone-resistant and CTX-M-15-producing Escherichia coli isolates belonging to clone ST131 have been reported in the community. This study was designed to identify these E. coli isolates in the stools of 332 independent healthy subjects living in the area of Paris, France. Stools were plated on media without antibiotics, in order to obtain the dominant (Dm) fecal E. coli strain, and with nalidixic acid (NAL) and cefotaxime. Quinolone susceptibility, phylogenetic groups, and molecular profiles, including multilocus sequence types (ST), were determined for all NAL-resistant (NAL-R) isolates. Groups were also determined for the Dm strains from participants with NAL-R isolates and from a subgroup without NAL-R isolates. All B2 isolates were typed; pulsed-field gel electrophoresis was performed for the ST131 isolates, and the results were compared with those for intercontinental clone ST131. Two participants (0.6%) had extended-spectrum β-lactamase-producing (SHV-2, TEM-52) fecal E. coli isolates, and 51 (15%) had NAL-R isolates; 51% of NAL-R isolates belonged to phylogenetic group A, 31% to group D, 16% to group B2, and 2% to group B1. The Dm strain was NAL-R in 3.3% of the 332 subjects. Forty-nine percent of the NAL-R isolates belonged to clones: ST10 and ST606 for group A isolates, ST117 and ST393 for group D isolates. Of all B2 isolates studied from 100 subjects (8 NAL-R strains; 19 NAL-susceptible dominant strains), 52% belonged to three clones: ST131 (n = 7), ST95 (n = 4), and ST141 (n = 3). This is the first study to show the presence of fecal E. coli isolates of clone ST131 in 7% of independent healthy subjects not colonized by CTX-M-15-producing isolates. PMID:18842941

3. (Photocopy of the second sheet of a threesheet set ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. (Photocopy of the second sheet of a three-sheet set entitled 'Kongensgade 45B-51') KING STREET (FRONT) ELEVATION OF KONGENSGADE 48 AND KING STREET (SIDE) ELEVATION OF KONGENS TVAERGADE 2 (2 KINGS CROSS ST.) - King Street Area Study, King Street, Christiansted, St. Croix, VI

[Changes in P-wave, T-wave, and ST segment amplitude in 12 lead electrocardiogram in children with breath holding spell].

PubMed

Zhang, Wenhua; Wang, Cheng; Zou, Runmei; Liu, Liping; Wu, Lijia; Luo, Xuemei; Li, Fang; Liao, Donglei; Cai, Hong

2016-06-28

To explore the change of the amplitude of P wave, T wave and ST segment of 12 lead electrocardiogram (ECG) in children with breath holding spell.
 A total of 29 children (24 males and 5 females) with breath holding spell in Second Xiangya Hospital, Central South University were enrolled for this study from October, 2009 to September, 2015. Their ages ranged from 3 months to 6 years, with an average of 1.82±1.27 years old. The control group consisted of 30 age-matched and gender-matched healthy children. All subjects were underwent electrocardiography by the SR-1000A comprehensive automatic electrocardiograph analyzer, and the changes of the ECG parameters were compared between the two groups.
 Compared with the control group, the amplitude of P-wave of V5 lead was decreased [(44.10±23.98) vs (58.30±21.19) μV, P<0.05], the amplitude of T-wave of V6 lead was increased [(423.80±122.6) vs (350.00±105.73) μV, P<0.05], the amplitude of ST segment of II lead was increased [(84.80±39.97) vs (57.30±38.77) μV, P<0.05], the amplitude of ST segment of aVR lead was increased [(-77.60±37.41) vs (-51.00±33.46) μV, P<0.05], the amplitude of ST segment of aVL lead was increased [(35.20±28.24) vs (17.70±33.90) μV, P<0.05], the amplitude of ST segment of V5 lead was increased [(111.00±59.36) vs (69.00±36.33) μV, P<0.05], the amplitude of ST segment of V6 lead was increased [(79.30±45.51) vs (51.30±33.19) μV, P<0.05]. 
 The children with breath holding spell have autonomic nerve dysfunction. The amplitude of ST segment changes is sensitive.

7. (Second sheet of a twosheet set entitled 'Kongensgade 5154') ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. (Second sheet of a two-sheet set entitled 'Kongensgade 51-54') KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 53 (only part of this elevation shown, for full elevation overlap with complementary photograph VI-50-6), & KONGENSGADE 54 (LEFT TO RIGHT) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

IN VITRO ANDROGENIC ACTIVITY OF KRAFT MILL EFFLUENT

EPA Science Inventory

In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, Nashville, TN. Society of Environmental Toxicology and Chemistry, Pensacola, FL. Pp. 102.

Female mosquito fish (Gambusia...

42 CFR 51.24 - Program priorities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Program priorities. 51.24 Section 51.24 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO... Priorities § 51.24 Program priorities. (a) Program priorities and policies shall be established annually by...

4. (Photocopy of the third sheet of a threesheet set ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. (Photocopy of the third sheet of a three-sheet set entitled 'Kongensgade 45B-51') KING STREET (FRONT) ELEVATIONS OF KONGENSGADE 49-50 AND OF KONGENSGADE 51 (see 'Lutheran Parsonage,' HABS No. VI-26) - King Street Area Study, King Street, Christiansted, St. Croix, VI

Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.

PubMed

Abide Yayla, Cigdem; Özkaya, Enis; Yenidede, Ilter; Eser, Ahmet; Ergen, Evrim Bostancı; Tayyar, Ahter Tanay; Şentürk, Mehmet Baki; Karateke, Ates

2018-02-01

The aim of this study was to discriminate mole pregnancies and invasive forms among cases with first trimester vaginal bleeding by the utilization of some complete blood count parameters conjunct to sonographic findings and beta human chorionic gonadotropin concentration. Consecutive 257 cases with histopathologically confirmed mole pregnancies and 199 women without mole pregnancy presented with first trimester vaginal bleeding who admitted to Zeynep Kamil Women and Children's Health Training Hospital between January 2012 and January 2016 were included in this cross-sectional study. The serum beta HCG level at presentation, and beta hCG levels at 1st, 2nd and 3rd weeks of postevacuation with some parameters of complete blood count were utilized to discriminate cases with molar pregnancy and cases with invasive mole among first trimester pregnants presented with vaginal bleeding and abnormal sonographic findings. Levels of beta hCG at baseline (AUC = 0.700, p < 0.05) and 1st (AUC = 0.704, p < 0.05), 2nd (AUC = 0.870, p < 0.001) and 3rd (AUC = 0.916, p < 0.001) weeks of postevacuation period were significant predictors for the cases with persistent disease. While area under curve for mean platelet volume is 0.715, it means that mean platelet volume has 21.5% additional diagnostic value for predicting persistency in molar patients. For 8.55 cut-off point for mean platelet volume, sensitivity is 84.6% and specificity is 51.6%. Area under curve for platelet/lymphocyte ratio is 0.683 means that platelet/lymphocyte ratio has additional 18.3% diagnostic value. For 102.25 cut-off point sensitivity is 86.6% and specificity is 46.2. Simple, widely available complete blood count parameters may be used as an adjunct to other risk factors to diagnose molar pregnancies and predict postevacuation trophoblastic disease.

The effect of bovine somatotropin on the cost of producing milk: Estimates using propensity scores.

PubMed

Tauer, Loren W

2016-04-01

Annual farm-level data from New York dairy farms from the years 1994 through 2013 were used to estimate the cost effect from bovine somatotropin (bST) using propensity score matching. Cost of production was computed using the whole-farm method, which subtracts sales of crops and animals from total costs under the assumption that the cost of producing those products is equal to their sales values. For a farm to be included in this data set, milk receipts on that farm must have comprised 85% or more of total receipts, indicating that these farms are primarily milk producers. Farm use of bST, where 25% or more of the herd was treated, ranged annually from 25 to 47% of the farms. The average cost effect from the use of bST was estimated to be a reduction of $2.67 per 100 kg of milk produced in 2013 dollars, although annual cost reduction estimates ranged from statistical zero to $3.42 in nominal dollars. Nearest neighbor matching techniques generated a similar estimate of $2.78 in 2013 dollars. These cost reductions estimated from the use of bST represented a cost savings of 5.5% per kilogram of milk produced. Herd-level production increase per cow from the use of bST over 20 yr averaged 1,160 kg. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Hematologic parameters and hemoparasites of nonmigratory Canada geese (Branta canadensis) from Greensboro, North Carolina, USA.

PubMed

Charles-Smith, Lauren E; Rutledge, M Elizabeth; Meek, Caroline J; Baine, Katherine; Massey, Elizabeth; Ellsaesser, Laura N; DePerno, Christopher S; Moorman, Christopher E; Degernes, Laurel A

2014-03-01

Large flocks of wild, nonmigratory Canada geese (Branta canadensis) have established permanent residence throughout the eastern United States and have become a public concern. Few studies have assessed the hematologic parameters for these populations, which could provide useful information for monitoring individual and population health of Canada geese. This study measured the hematologic parameters and detected the presence of hemoparasites from 146 wild, nonmigratory Canada geese in central North Carolina, USA, during their annual molt. The age class, sex, and weight of each bird were recorded at capture. Values for packed cell volume (PCV), estimated white blood cell count, white blood cell differentials, and heterophil: lymphocyte ratios were calculated for each bird. Adults and female geese had higher estimated white blood cell counts compared with juveniles and males, respectively. The PCV increased with weight and age class. Adult geese had higher percentages of heterophils and heterophil: lymphocyte ratios, whereas juvenile geese had higher percentages of lymphocytes. Relative eosinophil counts in adults increased with decreasing bird weight, and relative monocyte counts in juveniles increased with increasing weight. Three percent of geese were infected with species of Hemoproteus blood parasites. Atypical lymphocyte morphology, including pseudopods, split nuclei, and cytoplasmic granules, was observed in 5% of the birds. The hematologic values reported for adult and juvenile nonmigratory Canada geese in this study may serve as reference intervals for ecological studies and veterinary care of wild and captive Canada geese.

2012 Missouri Local Technical Assistance Program (LTAP) at Missouri S&T.

DOT National Transportation Integrated Search

2013-05-01

This annual report is a summary of the activities during 2012 for the Missouri Local Technical : Assistance Program (Missouri LTAP), which is located at Missouri University of Science and : Technology (Missouri S&T). It is submitted to the Missouri D...

5. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 1417 (LEFT TO RIGHT) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 14-17 (LEFT TO RIGHT) (see photograph VI-50-1 for plan of Kongensgade 17) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 8 AND 9 (LEFT TO RIGHT) (see photograph VI-50-1 for plans of Kongensgade 8 & 9) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

2. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 57 (LEFT TO RIGHT) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 5-7 (LEFT TO RIGHT) (see photograph VI-50-1 for plan of Kongensgade 6) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

The Royan Public Umbilical Cord Blood Bank: Does It Cover All Ethnic Groups in Iran Based on HLA Diversity?

PubMed

Ebrahimkhani, Saeideh; Farjadian, Shirin; Ebrahimi, Marzieh

2014-04-01

Umbilical cord blood (UCB) stem cells allow the transplantation of partially human leukocyte antigen (HLA)-matched grafts and are a valuable resource for the treatment of hematologic malignancies and heritable hematologic, immunologic and metabolic diseases, especially when a compatible bone marrow donor is unavailable. The aim of this study was to determine how many ethnic groups in Iran are covered by the available UCB units based on HLA diversity. From 2009 until mid-2013, 4,981 (30.3%) of the 16,437 UCB samples collected met the storage criteria and were cryopreserved at a public cord blood bank (CBB) in Tehran, Iran. HLA-A, -B and -DRB1 were typed in 1,793 samples. The mean volume of the cryopreserved samples was 81.25 ± 20.3 ml. The range of total nucleated cells per unit was 51 × 10(7)-107 × 10(7). The most common HLA alleles were HLA-A*2 (17%) and HLA-A*24 (15.6%), HLA-B*35 (16.8%) and HLA-B*51 (13.9%), and HLA-DRB1*11 (20%) and HLA-DRB1*15 (14%). The predominant haplotypes were HLA-A*24-B*35-DRB1*11 (2%), HLA-A*02-B*50-DR*07 (1.8%), and HLA-A*02-B*51-DRB1*11 (1.5%). Based on the HLA-DRB1 profiles, the UCB units available at the Royan public UCB bank are a potentially adequate resource for hematopoietic stem cell transplantation for Iranian recipients belonging to particular ethnic groups. Regular educational programs to improve the public knowledge of UCB for transplantation can enhance the public CBB stocks for all Iranian ethnic groups in the future.

Seasonal patterns of weight, hematology, and serum characteristics of free-ranging female white-tailed deer in Minnesota

USGS Publications Warehouse

DelGiudice, G.D.; Mech, L.D.; Kunkel, K.E.; Gese, E.M.; Seal, U.S.

1992-01-01

Weights, hematology, and serum profIles of white-tailed does in the central Superior National Forest of northeastern Minnesota were examined year-around to determine seasonal patterns of nutritional condition and metabolism. Deer were initially captured by Clover trap or rocket net. Between 15 February 1989 and 23 January 1990, we recaptured 12 adult (> 1.5 years) female deer 1-9 times each (a total of 59 recaptures) using a radio-controlled capture collar. Monthly weights of deer exhibited a cyclic seasonal pattern. Mean weight declined 22 % from February to an annual minimum during May, then steadily increased 45 % to a maximum in October. Seasonal patterns were most evident for hemoglobin concentration, red blood cells, packed cell volume, serum total protein, urea nitrogen, creatinine, the urea N to creatinine ratio, triiodothyronine, cortisol, and potassium. Wide seasonal variations of these characteristics were indicative of shifts in the deer's metabolic physiology. Although seasonal metabolic shifts are partially attributable to an endogenous rhythm, the intensity of, their expression was most likely affected by nutritional changes and concomitant alterations of body condition. Annual changes in seasonal trends of blood characteristics may be useful in investigating nutritional effects of specific environmental and demographic factors. We compare our findings with those reported for deer on ranges farther south.

[Quality assurance in airway management: education and training for difficult airway management].

PubMed

Kaminoh, Yoshiroh

2006-01-01

Respiratory problem is one of the main causes of death or severe brain damage in perioperative period. Three major factors of respiratory problem are esophageal intubation, inadequate ventilation, and difficult airway. The wide spread of pulse oximeter and capnograph reduced the incidences of esophageal intubation and inadequate ventilation, but the difficult airway still occupies the large portion in the causes of adverse events during anesthesia. "Practice guideline for management of the difficult airway" was proposed by American Society of Anesthesiologists (ASA) in 1992 and 2002. Improvement of knowledge, technical skills, and cognitive skills are necessary for the education and training of the difficult airway management. "The practical seminar of difficult airway management (DAM practical seminar)" has been cosponsored by the Japanese Association of Medical Simulation (JAMS) in the 51 st and 52 nd annual meetings of Japanese Society of Anesthesiologists and the 24th annual meeting of Japanese Society for Clinical Anesthesia. The DAM practical seminar is composed of the lecture session for ASA difficult airway algorithm, the hands-on training session for technical skills, and the scenario-based training session for cognitive skills. Ninty six Japanese anesthesiologists have completed the DAM practical seminar in one year. "The DAM instructor course" should be immediately prepared to organize the seminar more frequently.

The 47th annual Florida pesticide residue workshop

USDA-ARS?s Scientific Manuscript database

This is an introductory article to a special section of the Journal of Agricultural and Food Chemistry consisting of publications from the 47th Annual Florida Pesticide Residue Workshop held in St. Pete Beach, FL in July of 2010....

Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.

PubMed

Heo, Sang Taek; Tatara, Alexander M; Jiménez-Ortigosa, Cristina; Jiang, Ying; Lewis, Russell E; Tarrand, Jeffrey; Tverdek, Frank; Albert, Nathaniel D; Verweij, Paul E; Meis, Jacques F; Mikos, Antonios G; Perlin, David S; Kontoyiannis, Dimitrios P

2017-07-15

Azole-resistant aspergillosis in high-risk patients with hematological malignancy or hematopoietic stem cell transplantation (HSCT) is a cause of concern. We examined changes over time in triazole minimum inhibitory concentrations (MICs) of 290 sequential Aspergillus isolates recovered from respiratory sources during 1999-2002 (before introduction of the Aspergillus-potent triazoles voriconazole and posaconazole) and 2003-2015 at MD Anderson Cancer Center. We also tested for polymorphisms in ergosterol biosynthetic genes (cyp51A, erg3C, erg1) in the 37 Aspergillus fumigatus isolates isolated from both periods that had non-wild-type (WT) MICs. For the 107 patients with hematologic cancer and/or HSCT with invasive pulmonary aspergillosis, we correlated in vitro susceptibility with 42-day mortality. Non-WT MICs were found in 37 (13%) isolates and was only low level (MIC <8 mg/L) in all isolates. Higher-triazole MICs were more frequent in the second period and were Aspergillus-species specific, and only encountered in A. fumigatus. No polymorphisms in cyp51A, erg3C, erg1 genes were identified. There was no correlation between in vitro MICs with 42-day mortality in patients with invasive pulmonary aspergillosis, irrespective of antifungal treatment. Asian race (odds ratio [OR], 20.9; 95% confidence interval [CI], 2.5-173.5; P = .005) and azole exposure in the prior 3 months (OR, 9.6; 95% CI, 1.9-48.5; P = .006) were associated with azole resistance. Non-WT azole MICs in Aspergillus are increasing and this is associated with prior azole exposure in patients with hematologic cancer or HSCT. However, no correlation of MIC with outcome of aspergillosis was found in our patient cohort. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Circulating monoclonal immunoglobulins in Sjögren syndrome: prevalence and clinical significance in 237 patients.

PubMed

Brito-Zerón, Pilar; Ramos-Casals, Manuel; Nardi, Norma; Cervera, Ricard; Yagüe, Jordi; Ingelmo, Miguel; Font, Josep

2005-03-01

We conducted the current study to analyze the prevalence and clinical significance of circulating monoclonal immunoglobulins in patients with Sjögren syndrome (SS), focusing on the association with extraglandular features, immunologic markers, hematologic neoplasia, and hepatitis C virus (HCV) infection. We performed serum immunoelectrophoresis in 200 patients with primary SS and 37 patients with HCV-related SS. All patients fulfilled 4 or more of the 1993 European classification criteria for SS.Of the 200 patients with primary SS, 35 (18%) presented circulating monoclonal immunoglobulins. The monoclonal bands identified were 20 IgG (13 kappa, 7 lambda), 10 IgM (5 kappa, 5 lambda), 2 IgAkappa, and 3 free circulating light chains. Of the 37 SS-HCV patients, 16 (43%) had circulating monoclonal immunoglobulins. The monoclonal bands identified were 10 IgMkappa, 5 IgGlambda, and 1 free light lambda chain. Compared with primary SS patients, SS-HCV patients presented a higher frequency of monoclonal immunoglobulins (43% vs 18%, p = 0.001), with monoclonal IgMkappa being the most frequent monoclonal band. Six (12%) of the 51 SS patients with circulating monoclonal immunoglobulins presented hematologic neoplasia, compared with 3 (1.6%) of those without monoclonal immunoglobulins (p = 0.004; odds ratio = 8.13; 95% confidence intervals, 1.64-51.54). In 2 of the 6 patients with monoclonal immunoglobulins and lymphoproliferative disorders, a change of the monoclonal component was detected in previous immunoelectrophoresis determinations before the development of hematologic neoplasia. Circulating monoclonal immunoglobulins were detected in nearly 20% of patients with primary SS, with monoclonal IgG being the most frequent type of immunoglobulin detected. In SS-HCV patients, the prevalence of monoclonal immunoglobulins was higher (43%), with monoclonal IgM being the most frequent type found. SS-HCV patients presented a more restrictive monoclonal expression (limited to either monoclonal IgMkappa or monoclonal IgGlambda) than primary SS patients, who showed all types of heavy and light chains.

Kaolin

USGS Publications Warehouse

Virta, R.L.

2012-01-01

Fifteen companies mined kaolin in nine states in 2011. Production, on the basis of preliminary data, was estimated to be 5.48 Mt (6.04 million st) valued at $822 million, an increase from 5.42 Mt (5.97 million st) valued at $788 million in 2010. Production in Georgia, the top producing state, increased to an estimated 5.1 Mt (5.62 million st) valued at $790 million in 2011 from 5.05 Mt (5.57 million st) valued at $757 million in 2010. Georgia accounted for 93 percent of U.S. production tonnage and nearly the entire domestic water-washed, delaminated and pigment-grade calcined kaolin production.

[Modularization by the open standard. (I)].

PubMed

Hirano, H

2000-10-01

We are proceeding with the project called "Open LA21 Project" in the course of the clinical laboratory automation toward the 21st century. With the modular system that realizes integration, downsizing, a reasonable price, and is the future course in the clinical testing automation system as well, we aim to establish common standards among manufacturers as the only way to create user friendly market environments where the proper competition exists among the manufacturers. The common standards which are in preparation by the participating companies as "Open module system standards" are the standards which are going to be made public. They are intended to guarantee connection, compatibility of the products in conformity with the standards. In this project, we intend to realize the modular system that integrates each field, such as chemistry, hematology, coagulation/fibrinolysis, immunology, urinalysis in an early stage, and contribute positively to restructuring and upgrading the "raison d'etre" of the 21st century clinical testing.

47 CFR 1.1152 - Schedule of annual regulatory fees and filing locations for wireless radio services.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) (47 CFR, Part 90) (a) New, Renew/Mod (FCC 601 & 159) $40.00 FCC, P.O. Box 979097, St. Louis, MO 63197-9000. (b) New, Renew/Mod (Electronic Filing) (FCC 601 & 159) 40.00 FCC, P.O. Box 979097, St. Louis, MO 63197-9000. (c) Renewal Only (FCC 601 & 159) 40.00 FCC, P.O. Box 979097, St. Louis, MO 63197-9000. (d...

Assessment of Theileria equi and Babesia caballi infections in equine populations in Egypt by molecular, serological and hematological approaches.

PubMed

Mahmoud, Mona S; El-Ezz, Nadia T Abu; Abdel-Shafy, Sobhy; Nassar, Somia A; El Namaky, Amira H; Khalil, Wagdy K B; Knowles, Don; Kappmeyer, Lowell; Silva, Marta G; Suarez, Carlos E

2016-05-04

Equine piroplasmosis (EP) caused by Theileria equi, Babesia caballi, or both, contributes to significant economic loss in the equine industry and remains uncontrolled in Egypt. This study focuses on surveying T. equi and B. caballi infections and hematological disorders in equine populations in Egypt. Theileria equi and B. caballi infections were assessed in blood from 88 horses and 51 donkeys in Egypt using light microscopy, indirect immunofluorescent antibody test (IFAT), nested PCR (nPCR), and competitive-ELISA (cELISA) assays. PCR products were examined for specificity by DNA sequencing. Hematological alterations were evaluated using a standard cell counter. Microscopic analysis revealed EP infection in 11.4% and 17.8% of horses and donkeys respectively. IFAT detected 23.9% and 17.0% infection of T. equi and B. caballi, respectively, in horses, and 31.4% of T. equi and B. caballi in donkeys. T. equi cELISA detected 14.8% and 23.5% positive horses and donkeys, respectively, but the B. caballi RAP-1-based cELISA failed to detect any positives, a result hypothesized to be caused by sequence polymorphism found in the rap-1 genes. Nested-PCR analysis identified 36.4% and 43.1% positive horses and donkeys, respectively for T. equi and it also identified 19.3% and 15.7% positive horses and donkeys, respectively for B. caballi. The overall EP incidence found in the population under study was relatively high and comparable regardless of the diagnostic method used (56.8% using nPCR and 48.9% using IFAT). Hematologic analysis revealed macrocytic hypochromic anemia and thrombocytopenia in all piroplasma-infected horses. The data confirm relatively high levels of EP, likely causing hematological abnormalities in equines in Egypt, and also suggest the need for an improved serological test to diagnose B. caballi infection in this region.

Epidemiological and mycological characteristics of candidemia in patients with hematological malignancies attending a tertiary-care center in India.

PubMed

Dewan, Eshani; Biswas, Debasis; Kakati, Barnali; Verma, S K; Kotwal, Aarti; Oberoi, Aroma

2015-09-01

We undertook the present study to ascertain the contributing risk factors and explore the epidemiological and mycological characteristics of opportunistic candidemia among patients with hematological malignancies. Observational cross-sectional study in a tertiary care center. Consecutive patients with hematological malignancies reporting to the collaborating medical and pediatric units with a febrile episode were recruited and screened for candidemia by blood culture. Recovered Candida isolates were speciated and antifungal susceptibility testing was performed as per Clinical and Laboratory Standards Institute guideline (CLSI) guidelines M44-A. Further analysis was done for potential risk factors and compared between culture positive and negative patients. Of 150 patients recruited, the majority (n=27) were between 51 and 60 years and the male to female ratio was 1.63:1. Fifteen patients (10%) were culture positive. The culture positivity was significantly higher in acute lymphocytic leukemia (ALL) than in non-ALL patients (p=0.03). There was significant association of candidaemia with leucopenia, chemotherapeutic drugs, corticosteroids and presence of indwelling devices. Duration of disease (p=0.032) and duration of hospitalization (p=0.003) were significantly prolonged in culture positive patients. C. tropicalis was the commonest isolate (46.67%), with non- Candida albicans outnumbering C. albicans in all categories of hematological malignancies (2.75:1). All isolates of C. albicans were uniformly sensitive to all the azoles, but only 50% were sensitive to amphotericin B and none to nystatin and flucytosine. This observational study identifies ALL and chronic lymphocytic leukemia (CLL) as the forms of hematological malignancy predominantly associated with candidemia; specifies risk factors and chemotherapeutic agents predisposing patients towards its occurrence; reports a preponderance of C. tropicalis among the causative agents and finds voriconazole to be the most effective antifungal agent against the recovered isolates. This information could assist in tailoring prophylactic and therapeutic antifungal practices for this infection, according to local epidemiological and mycological characteristics. Copyright © 2015. Published by Elsevier B.V.

Hematological and serum chemistry norms for sandhill and whooping cranes

USGS Publications Warehouse

Olsen, Glenn H.; Hendricks, M.M.; Dressler, L.E.

2001-01-01

The normal values used as a diagnostic tool and for comparison of cranes were established in the early 1970's. In that early study, no effort was made to look at factors such as age, sex, or subspecies. In addition, during the early study disease problems (primarily disseminated visceral coccidiosis) and nutritional problems were undiagnosed and uncontrolled. For 2 years during the annual health examinations of cranes at the USGS Patuxent Wildlife Research Center (Patuxent), we collected blood from healthy cranes for analysis. We found significant differences between the values reported from the 1970's and the values seen in this study for 8 blood parameters for Florida sandhill cranes (Grus canadensis pratensis), 6 blood parameters for greater sandhill cranes (G. c. tabida), and 6 blood parameters for whooping cranes (Grus americana). In addition, there were significant differences for some hematology and serum chemistry values based on the age of the cranes.

33 CFR 165.941 - Safety Zones; Annual Events in the Captain of the Port Detroit Zone.

Code of Federal Regulations, 2014 CFR

2014-07-01

... will be determined annually. (4) The Old Club Fireworks, Harsens Island, MI: (i) Location: All waters...′ N, 082°40.1′ W (NAD 83). This area is located near the southern end of Harsens Island, MI. (ii... determined annually. (10) Nautical Mile Venetian Festival Fireworks, St. Clair Shores, MI: (i) Location: All...

33 CFR 165.941 - Safety Zones; Annual Events in the Captain of the Port Detroit Zone.

Code of Federal Regulations, 2013 CFR

2013-07-01

... will be determined annually. (4) The Old Club Fireworks, Harsens Island, MI: (i) Location: All waters...′ N, 082°40.1′ W (NAD 83). This area is located near the southern end of Harsens Island, MI. (ii... determined annually. (10) Nautical Mile Venetian Festival Fireworks, St. Clair Shores, MI: (i) Location: All...

33 CFR 165.941 - Safety Zones; Annual Events in the Captain of the Port Detroit Zone.

Code of Federal Regulations, 2012 CFR

2012-07-01

... will be determined annually. (4) The Old Club Fireworks, Harsens Island, MI: (i) Location: All waters...′ N, 082°40.1′ W (NAD 83). This area is located near the southern end of Harsens Island, MI. (ii... determined annually. (10) Nautical Mile Venetian Festival Fireworks, St. Clair Shores, MI: (i) Location: All...

Intelligent vehicle initiative : 2002 annual report -- saving lives through advanced vehicle safety technology

DOT National Transportation Integrated Search

2003-05-15

This Annual Report provides an overview of the Intelligent Vehicle Initiatives (IVIs) progress and accomplishments during 2002. The 1998 Transportation Efficiency Act for the 21st Century (TEA-21) authorized IVI as part of the Department of Tra...

Novel Small Molecule Antagonists of the Interaction of the Androgen Receptor and Transcriptional Co-regulators

DTIC Science & Technology

2009-01-01

ORGANIZATION: St. Jude Research Children’s Hospital Memphis, TN 38105 REPORT DATE...January 2009 TYPE OF REPORT: Annual Summary PREPARED FOR: U.S. Army Medical Research and Materiel Command...PERFORMING ORGANIZATION REPORT NUMBER St. Jude Research Children’s Hospital Memphis, TN

DETAILED ENDOCRINE ASSESSMENTS IN WILD FISH DOWNSTREAM OF PULP AND PAPER MILLS IN NORTHERN ALBERTA, CANADA

EPA Science Inventory

2001. Detailed Endocrine Assessments in Wild Fish Downstream of Pulp and Paper Mills in Northern Alberta, Canada (Abstract). In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, N...

78 FR 38829 - Special Local Regulations; Recurring Marine Events in the Seventh Coast Guard District

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... regulation for the St. John 4th of July Carnival Fireworks Display from 8 p.m. until 10 p.m. on July 4, 2013...: The Coast Guard will enforce the special local regulation for the annual St. John 4th of July Carnival...

Hemispheric Differences in Tropical Lower Stratospheric Transport and Tracers Annual Cycle

NASA Technical Reports Server (NTRS)

Tweedy, Olga; Waugh, D.; Stolarski, R.; Oman, L.

2016-01-01

Transport of long-lived tracers (such as O, CO, and N O) in the lower stratosphere largely determines the composition of the entire stratosphere. Stratospheric transport includes the mean residual circulation (with air rising in the tropics and sinking in the polar and middle latitudes), plus two-way isentropic (quasi-horizontal) mixing by eddies. However, the relative importance of two transport components remains uncertain. Previous studies quantified the relative role of these processes based on tropics-wide average characteristics under common assumption of well-mixed tropics. However, multiple instruments provide us with evidence that show significant differences in the seasonal cycle of ozone between the Northern (0-20N) and Southern (0-20S) tropical (NT and ST respectively) lower stratosphere. In this study we investigate these differences in tracer seasonality and quantify transport processes affecting tracers annual cycle amplitude using simulations from Goddard Earth Observing System Chemistry Climate Model (GEOSCCM) and Whole Atmosphere Community Climate Model (WACCM) and compare them to observations from the Microwave Limb Sounder (MLS) on the Aura satellite. We detect the observed contrast between the ST and NT in GEOSCCM and WACCM: annual cycle in ozone and other chemical tracers is larger in the NT than in the ST but opposite is true for the annual cycle in vertical advection. Ozone budgets in the models, analyzed based on the Transformed Eulerian Mean (TEM) framework, demonstrate a major role of quasi-horizontal mixing vertical advection in determining the NTST ozone distribution and behavior. Analysis of zonal variations in the NT and ST ozone annual cycles further suggests important role of North American and Asian Summer Monsoons (associated with strong isentropic mixing) on the lower stratospheric ozone in the NT. Furthermore, multi model comparison shows that most CCMs reproduce the observed characteristic of ozone annual cycle quite well. Thus, latitudinal variations within the tropics have to be considered in order to understand the balance between upwelling and quasi- horizontal mixing in the tropical lower stratosphere and the paradigm of well mixed tropics has to be reconsidered.

Weights and hematology of wild black bears during hibernation

USGS Publications Warehouse

DelGiudice, Glenn D.; Rogers, Lynn L.; Allen, Arthur W.; Seal, U.S.

1991-01-01

We compared weights and hematological profiles of adult (greater than 3-yr-old) female black bears (Ursus americanus) during hibernation (after 8 January). We handled 28 bears one to four times (total of 47) over 4 yr of varying mast and berry production. Mean weight of lactating bears was greater (P less than 0.0001) than that of non-lactating females. White blood cells (P less than 0.05) and mean corpuscular volume (P = 0.005) also differed between lactating and non-lactating bears. Hemoglobin (P = 0.006) and mean corpuscular hemoglobin concentration (P = 0.02) varied among years; values were lowest during 1975, following decreased precipitation and the occurrence of a second year of mast and berry crop shortages in a three-year period. Significant (P less than 0.05) interaction between reproductive status (lactating versus non-lactating) and study year for hemoglobin, red blood cells, and packed cell volume, and increased mean corpuscular volume, suggested a greater nutritional challenge for lactating females compared to non-lactating females during the 1975 denning season. Our data suggest that hematological characteristics of denning bears may be more sensitive than weights as indicators of annual changes in nutritional status; however, other influential factors, in addition to mast and berry crop production, remain to be examined.

Trend analysis of watershed-scale precipitation over Northern California by means of dynamically-downscaled CMIP5 future climate projections.

PubMed

Ishida, K; Gorguner, M; Ercan, A; Trinh, T; Kavvas, M L

2017-08-15

The impacts of climate change on watershed-scale precipitation through the 21st century were investigated over eight study watersheds in Northern California based on dynamically downscaled CMIP5 future climate projections from three GCMs (CCSM4, HadGEM2-ES, and MIROC5) under the RCP4.5 and RCP8.5 future climate scenarios. After evaluating the modeling capability of the WRF model, the six future climate projections were dynamically downscaled by means of the WRF model over Northern California at 9km grid resolution and hourly temporal resolution during a 94-year period (2006-2100). The biases in the model simulations were corrected, and basin-average precipitation over the eight study watersheds was calculated from the dynamically downscaled precipitation data. Based on the dynamically downscaled basin-average precipitation, trends in annual depth and annual peaks of basin-average precipitation during the 21st century were analyzed over the eight study watersheds. The analyses in this study indicate that there may be differences between trends of annual depths and annual peaks of watershed-scale precipitation during the 21st century. Furthermore, trends in watershed-scale precipitation under future climate conditions may be different for different watersheds depending on their location and topography even if they are in the same region. Copyright © 2017 Elsevier B.V. All rights reserved.

Exclusion of Older Patients From Ongoing Clinical Trials for Hematological Malignancies: An Evaluation of the National Institutes of Health Clinical Trial Registry

PubMed Central

Stauder, Reinhard; van Munster, Barbara C.

2014-01-01

Introduction. Cancer societies, research cooperatives, and countless publications have urged the development of clinical trials that facilitate the inclusion of older patients and those with comorbidities. We set out to determine the characteristics of currently recruiting clinical trials with hematological patients to assess their inclusion and exclusion of elderly patients. Methods. The NIH clinical trial registry was searched on July 1, 2013, for currently recruiting phase I, II or III clinical trials with hematological malignancies. Trial characteristics and study objectives were extracted from the registry website. Results. Although 5% of 1,207 included trials focused exclusively on elderly or unfit patients, 69% explicitly or implicitly excluded older patients. Exclusion based on age was seen in 27% of trials, exclusion based on performance status was seen in 16%, and exclusion based on stringent organ function restrictions was noted in 51%. One-third of the studies that excluded older patients based on age allowed inclusion of younger patients with poor performance status; 8% did not place any restrictions on organ function. Over time, there was a shift from exclusion based on age (p value for trend <.001) toward exclusion based on organ function (p = .2). Industry-sponsored studies were least likely to exclude older patients (p < .001). Conclusion. Notably, 27% of currently recruiting clinical trials for hematological malignancies use age-based exclusion criteria. Although physiological reserves diminish with age, the heterogeneity of the elderly population does not legitimize exclusion based on chronological age alone. Investigators should critically review whether sufficient justification exists for every exclusion criterion before incorporating it in trial protocols. PMID:25170014

Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health Clinical Trial Registry.

PubMed

Hamaker, Marije E; Stauder, Reinhard; van Munster, Barbara C

2014-10-01

Cancer societies, research cooperatives, and countless publications have urged the development of clinical trials that facilitate the inclusion of older patients and those with comorbidities. We set out to determine the characteristics of currently recruiting clinical trials with hematological patients to assess their inclusion and exclusion of elderly patients. The NIH clinical trial registry was searched on July 1, 2013, for currently recruiting phase I, II or III clinical trials with hematological malignancies. Trial characteristics and study objectives were extracted from the registry website. Although 5% of 1,207 included trials focused exclusively on elderly or unfit patients, 69% explicitly or implicitly excluded older patients. Exclusion based on age was seen in 27% of trials, exclusion based on performance status was seen in 16%, and exclusion based on stringent organ function restrictions was noted in 51%. One-third of the studies that excluded older patients based on age allowed inclusion of younger patients with poor performance status; 8% did not place any restrictions on organ function. Over time, there was a shift from exclusion based on age (p value for trend <.001) toward exclusion based on organ function (p = .2). Industry-sponsored studies were least likely to exclude older patients (p < .001). Notably, 27% of currently recruiting clinical trials for hematological malignancies use age-based exclusion criteria. Although physiological reserves diminish with age, the heterogeneity of the elderly population does not legitimize exclusion based on chronological age alone. Investigators should critically review whether sufficient justification exists for every exclusion criterion before incorporating it in trial protocols. ©AlphaMed Press.

The role of ¹⁸F-FDG PET/CT for the diagnosis of infections in patients with hematological malignancies and persistent febrile neutropenia.

PubMed

Gafter-Gvili, Anat; Paul, Mical; Bernstine, Hanna; Vidal, Liat; Ram, Ron; Raanani, Pia; Yeshurun, Moshe; Tadmor, Boaz; Leibovici, Leonard; Shpilberg, Ofer; Groshar, David

2013-09-01

We assessed the performance of PET/CT for diagnosis and management of infections in high-risk hematological cancer patients with persistent febrile neutropenia in a prospective study. (18)F-FDG PET/CT with contrast-enhanced CT was performed on day 5-7 of persistent fever. Between 2008 and 2011, 91 PET/CT examinations were performed for different episodes in 79 patients, resulting in 117 diagnoses. The sensitivity of the PET/CT was 79.8% (71/89) compared to 51.7% (46/89) with chest/sinus CT alone. Specificities were 32.14% (9/28) vs. 42.85% (12/28), respectively. PET/CT resulted in a change from the pre-test diagnosis in 63/91 (69%) of episodes and in modification of patients' management in 46/91 (55%). PET/CT was beneficial in diagnosing abdominal infections. PET/CT has a potential role in the diagnostic evaluation of patients with persistent febrile neutropenia. Copyright © 2013 Elsevier Ltd. All rights reserved.

Air Quality Side Event Proposal November 2016 GEO XIII Plenary in St. Petersburg, Russia

EPA Science Inventory

The Group on Earth Observations (GEO), which EPA has participated in since 2003, has put out a call for Side Events for its thirteenth annual international Plenary Meeting which is in St. Petersburg, Russia this year during November, 2016. EPA has put on Side Events on Air Quali...

42 CFR 51.10 - Remedial actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Remedial actions. 51.10 Section 51.10 Public Health... actions. Failure to submit an annual report in the designated format on time or to submit requested information and documentation, corrective action plans and ongoing implementation status reports in response...

Suspended Sediment Loads and Tributary Inputs in the Mississippi River below St. Louis, MO, 1990-2013 Compared With Earlier Results

NASA Astrophysics Data System (ADS)

Allison, M. A.; Biedenharn, D. S.; Dahl, T. A.; Kleiss, B.; Little, C. D.

2017-12-01

Annual suspended sediment loads and water discharges were calculated in the Mississippi River mainstem channel, and at the most downstream gaging station for major tributaries, from below the Missouri confluence near St. Louis, MO to Belle Chasse, LA, as well as down the Atchafalaya distributary for water years 1990 to 2013. The purpose of the present study was to assess changes in the Mississippi River sediment budget over the past half century, and to examine the continuing role that anthropogenic (e.g., dams, river control works, soil conservation practices) and natural (e.g., rainfall and denudation rates) factors have in controlling these changes. Sixteen of the 17 measured Mississippi River tributaries decreased in total suspended sediment load) from 1970-1978 to 1990-2013. The largest decreases occurred in the 2nd (Ohio River, 41% of 1970-1978) and 4th (Arkansas River, 45% of 1970-1978) largest water sources to the Mississippi. The Missouri River remains the largest Mississippi River tributary in terms of average annual suspended sediment flux; its relative contribution increased from 38% to 51% of the total flux from the 17 measured tributaries, even as its total suspended flux declined by 13%. Averaged over the period of study (WY 1990-2013), water flux increased by 468% and sediment flux increased by 37,418% downstream from the Gavin's Point Dam to the confluence with the Mississippi. Possible reasons for this disproportional increase in suspended sediment load downstream include sediment-rich contributions from 2nd order rivers below the dams and channel incision. Suggested station improvements to the system include improved monitoring of the Upper Mississippi and Arkansas River tributaries, establishing additional mainstem stations in the reach between Thebes, IL and Arkansas City, AR, and standardization of laboratory and field methodologies to eliminate a major source of station-to-station and time-series variability in the sediment budgeting.

New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016.

PubMed

Adusumilli, Prasad S; Cha, Edward; Cornfeld, Mark; Davis, Thomas; Diab, Adi; Dubensky, Thomas W; Evans, Elizabeth; Grogan, Jane L; Irving, Bryan A; Leidner, Rom S; Olwill, Shane A; Soon-Shiong, Patrick; Triebel, Frederic; Tuck, David; Bot, Adrian; Dansey, Roger D; Drake, Charles G; Freeman, Gordon J; Ibrahim, Ramy; Patel, Salil; Chen, Daniel S

2017-01-01

This report is a summary of 'New Cancer Immunotherapy Agents in Development' program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy.

Multiple Myeloma: Clinical Updates From the American Society of Hematology Annual Meeting, 2017.

PubMed

Terpos, Evangelos

2018-05-01

The novel clinical data for myeloma that were presented in the 2017 Annual Meeting of the American Society of Hematology are summarized here. Studies with curative approach (CESAR) or prolonging progression-free survival (CENTAURUS) for patients with high-risk smoldering multiple myeloma (SMM) are described. Updated data from large phase III studies for patients with newly diagnosed MM (NDMM) who are eligible for autologous stem cell transplantation (ASCT) (EMN02, MRC XI) are described, along with the results of studies using novel anti-myeloma drug combinations for induction, consolidation, and maintenance as first-line therapy. The role of minimal residual disease for patients with MM is also discussed. We also present the results of novel phase III studies in patients with NDMM who are not eligible for ASCT (ALCYONE) and new data for their treatment. Recent updates of important studies in the field of relapsed/refractory MM (ASPIRE, POLLUX) along with novel immunotherapy approaches (anti-BCMA monoclonal antibodies, CART cells) are also reported. Finally, levofloxacin prophylaxis reduces febrile episodes and death events in NDMM, whereas 2 doses of high-dose influenza vaccine seem to maintain higher rates of seroprotection compared with those who received standard vaccination. All these data provide the basis for possible changes in the way we manage myeloma in the near future trying to "cure" the disease in many patients. Copyright © 2018 Elsevier Inc. All rights reserved.

78 FR 24466 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

.... Affected Public: Private Sector: Businesses or other for-profits. Estimated Annual Burden Hours: 24,206,448... correctly computed. Affected Public: Private Sector: Businesses or other for-profits. Estimated Annual...: Private Sector: Businesses or other for-profits. Estimated Annual Burden Hours: 51,024. OMB Number: 1545...

Effects of maximum intensity aerobic swimming exercise until exhaustion at different times of day on the hematological parameters in rats.

PubMed

Beck, W; Gobatto, Claudio Alexandre

2013-12-01

The aims of this study were: a) to analyze the time of day effect on the aerobic capacity and time to exhaustion at aerobic capacity intensity (TE), and b) to analyze the physiological impact of handling and exercise testing during the light and dark periods, based on hematological parameters. Eighty rats were randomly divided into two control groups (C12 and C20) and two exercise groups (E12 and E20), assessed at 12:00 h (C12 and E12) or 20:00 h (C20 and E20). The lactate minimum intensity (LMi) was measured and after 48 h the exercise groups were subjected to a bout of swimming until exhaustion at LMi (TE). The TE was 1.30 ± 0.51 h for the E12 group and 1.81 ± 0.77 h for the E20 group (p = 0.03). The time of day effect was significant for all white blood cell counts (12:00 h > 20:00 h). Chronic handling and performing exercise tests at 12:00 h (light period) resulted in an increased WBC counts and decreased exercise tolerance. The favorable time of day for aerobic capacity and performance assessment and hematological parameters was at 20:00 h (dark period), which is associated with the wakefulness period of the assessed animals.

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Isolates in the Gulf Cooperation Council States: Dominance of OXA-23-Type Producers

PubMed Central

Sartor, Anna L.; Sidjabat, Hanna E.; Balkhy, Hanan H.; Walsh, Timothy R.; Al Johani, Sameera M.; AlJindan, Reem Y.; Alfaresi, Mubarak; Ibrahim, Emad; Al-Jardani, Amina; Al Salman, Jameela; Dashti, Ali A.; Johani, Khalid; Paterson, David L.

2015-01-01

The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Acinetobacter baumannii (CRAB) were determined in hospitals in the states of the Cooperation Council for the Arab States of the Gulf (Gulf Cooperation Council [GCC]), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic resistance genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Selected isolates were subjected to multilocus sequence typing (MLST). We investigated 117 isolates resistant to carbapenem antibiotics (either imipenem or meropenem). All isolates were positive for OXA-51. The most common carbapenemases were the OXA-23-type, found in 107 isolates, followed by OXA-40-type (OXA-24-type), found in 5 isolates; 3 isolates carried the ISAba1 element upstream of blaOXA-51-type. No OXA-58-type, NDM-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with 16 clusters of clonally related CRAB. Some clusters involved hospitals in different states. MLST analysis of 15 representative isolates from different clusters identified seven different sequence types (ST195, ST208, ST229, ST436, ST450, ST452, and ST499), as well as three novel STs. The vast majority (84%) of the isolates in this study were associated with health care exposure. Awareness of multidrug-resistant organisms in GCC states has important implications for optimizing infection control practices; establishing antimicrobial stewardship programs within hospital, community, and agricultural settings; and emphasizing the need for establishing regional active surveillance systems. This will help to control the spread of CRAB in the Middle East and in hospitals accommodating transferred patients from this region. PMID:25568439

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council States: dominance of OXA-23-type producers.

PubMed

Zowawi, Hosam M; Sartor, Anna L; Sidjabat, Hanna E; Balkhy, Hanan H; Walsh, Timothy R; Al Johani, Sameera M; AlJindan, Reem Y; Alfaresi, Mubarak; Ibrahim, Emad; Al-Jardani, Amina; Al Salman, Jameela; Dashti, Ali A; Johani, Khalid; Paterson, David L

2015-03-01

The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Acinetobacter baumannii (CRAB) were determined in hospitals in the states of the Cooperation Council for the Arab States of the Gulf (Gulf Cooperation Council [GCC]), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic resistance genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Selected isolates were subjected to multilocus sequence typing (MLST). We investigated 117 isolates resistant to carbapenem antibiotics (either imipenem or meropenem). All isolates were positive for OXA-51. The most common carbapenemases were the OXA-23-type, found in 107 isolates, followed by OXA-40-type (OXA-24-type), found in 5 isolates; 3 isolates carried the ISAba1 element upstream of blaOXA-51-type. No OXA-58-type, NDM-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with 16 clusters of clonally related CRAB. Some clusters involved hospitals in different states. MLST analysis of 15 representative isolates from different clusters identified seven different sequence types (ST195, ST208, ST229, ST436, ST450, ST452, and ST499), as well as three novel STs. The vast majority (84%) of the isolates in this study were associated with health care exposure. Awareness of multidrug-resistant organisms in GCC states has important implications for optimizing infection control practices; establishing antimicrobial stewardship programs within hospital, community, and agricultural settings; and emphasizing the need for establishing regional active surveillance systems. This will help to control the spread of CRAB in the Middle East and in hospitals accommodating transferred patients from this region. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Effect of granulocyte-colony stimulating factor on empiric therapy with flomoxef sodium and tobramycin in febrile neutropenic patients with hematological malignancies. Kan-etsu Hematological Disease and Infection Study Group.

PubMed

Yoshida, M; Karasawa, M; Naruse, T; Fukuda, M; Hirashima, K; Oh, H; Ninomiya, H; Abe, T; Saito, K; Shishido, H; Moriyama, Y; Shibata, A; Motoyoshi, K; Nagata, N; Miura, Y

1999-02-01

The clinical effects of concomitant use of granulocyte-colony stimulating factor (G-CSF) on empiric antibiotic therapy in febrile neutropenic patients were evaluated in a randomized fashion. Two hundred and fourteen neutropenic febrile episodes (neutrophil counts < 1.0 x 10(9)/l) were treated with flomoxef sodium and tobramycin with or without G-CSF. The resolution of fever at day 4 (excellent response) or at day 7 (good response) was deemed effective. Among 157 evaluable episodes, the observed excellent responses were 31 (38.8%) and the good responses were 20 (25.0%) in the G-CSF group; those in the control group were 26 (33.8%) and 25 (32.5%), respectively. The overall efficacy rate was 63.8% (51/80) in the G-CSF group and 66.2% (51/77) in the control group (not significant). The initial neutrophil count was 0.186 +/- 0.249 x 10(9)/l in the G-CSF group and 0.235 +/- 0.290 x 10(9)/l in the control group, and rose to 2.889 +/- 4.198 x 10(9)/l and 0.522 +/- 0.844 x 10(9)/l, respectively, at day 7. These results indicate that G-CSF does not affect the rate of response to empiric antibiotic therapy in febrile neutropenic patients, although a significant effect of G-CSF was observed on neutrophil recovery.

Annual Proceedings of Selected Research and Development Papers Presented at the Annual Convention of the Association for Educational Communications and Technology (31st, Orlando, FL, 2008)

ERIC Educational Resources Information Center

Simonson, Michael, Ed.

2008-01-01

For the thirty-first year, the Research and Theory Division of the Association for Educational Communications and Technology (AECT) sponsored the publication of these Proceedings. Papers were presented at the annual AECT Convention in Orlando, Florida. This year's Proceedings has two sections--Section 1 includes research and development papers and…

9. (Second sheet of a twosheet set entitled "Kongensgade 5558") ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. (Second sheet of a two-sheet set entitled "Kongensgade 55-58") KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 57 & 58 (LEFT TO RIGHT) (see photograph VI-50-1 for plan of Kongensgade 57) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

8. (First sheet of a twosheet set entitled "Kongensgade 5558") ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. (First sheet of a two-sheet set entitled "Kongensgade 55-58") KONGENSGADE (FRONT) ELEVATIONS OF KONGENSGADE 55 & 56 (LEFT TO RIGHT) (see photograph VI-50-1 for plan of Kongensgade 56) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

Toward the 21st Century. A Continent in Crisis: Building a Future for Africa in the 21st Century. A Special Report by the Population Institute to the 101st Congress.

ERIC Educational Resources Information Center

Burdett, Hal; And Others

Africa's population is now 630 million, and it is growing faster than any other region in the world. But while Africa's population grows by 3.1 percent annually, the continent's food supply increases by only 1.1 percent per year. Throughout the 1980s more and more African governments have agreed that lasting development is possible only if…

Annual minimum temperature variations in early 21st century in Punjab, Pakistan

NASA Astrophysics Data System (ADS)

Jahangir, Misbah; Maria Ali, Syeda; Khalid, Bushra

2016-01-01

Climate change is a key emerging threat to the global environment. It imposes long lasting impacts both at regional and national level. In the recent era, global warming and extreme temperatures have drawn great interest to the scientific community. As in a past century considerable increase in global surface temperatures have been observed and predictions revealed that it will continue in the future. In this regard, current study mainly focused on analysis of regional climatic change (annual minimum temperature trends and its correlation with land surface temperatures in the early 21st century in Punjab) for a period of 1979-2013. The projected model data European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-Interim) has been used for eight Tehsils of Punjab i.e., annual minimum temperatures and annual seasonal temperatures. Trend analysis of annual minimum and annual seasonal temperature in (Khushab, Noorpur, Sargodha, Bhalwal, Sahiwal, Shahpur, Sillanwali and Chinoit) tehsils of Punjab was carried out by Regression analysis and Mann-Kendall test. Landsat 5 Thematic Mapper (TM) data was used in comparison with Model data for the month of May from the years 2000, 2009 and 2010. Results showed that no significant trends were observed in annual minimum temperature. A significant change was observed in Noorpur, Bhalwal, Shahpur, Sillanwali, Sahiwal, Chinoit and Sargodha tehsils during spring season, which indicated that this particular season was a transient period of time.

Military Applications of High-Altitude Satellite Orbits in a Multi-Body Dynamical Environment Using Numerical Methods and Dynamical Systems Theory

DTIC Science & Technology

2016-03-01

Anno vi Acknowledgments First, I would like to express my incredible gratitude...Earth-Moon and Sun-Earth systems in Table 1. 51 T a b le 1 . J a c o b i C o n st a n t V a lu e s a n d R o ta ti n g F ra m e C o o rd in a te s o...g C o o rd in a te s in S y st em E q u a l M a ss S y st em P o in t E a rt h -M o o n S y st em in J a co b i C o n st a n t

Evaluation of health status of horses immunized with snake venom and montanide adjuvants, IMS 3012 (nanoparticle), ISA 206 and ISA 35 (emulsion based) during polyvalent snake antivenom production: hematological and biochemical assessment.

PubMed

Waghmare, A B; Salvi, N C; Deopurkar, R L; Shenoy, P A; Sonpetkar, J M

2014-05-01

Several biochemical and hematological changes in horses are observed during production of snake antivenom. Although conventional adjuvants like Freund's (Complete and Incomplete) are good immunopotentiators, they produce considerable local reactions in animals. Variety of commercial adjuvants, like montanide adjuvants, having high immunopotentiation and showing lesser side effects are available. The prime objective during antivenom production is to strike a balance between safety of immunized horses and efficacy of the product. In our earlier work, efficacy of montanide group of adjuvants in antivenom production has already been established. The aim of the present work was to assess the safety parameters in horses, viz.: biochemical and hematological, during production of snake antivenom. In the present study, 33 new horses were randomly divided into four groups and hyperimmunized using mixture of snake venoms, viz.: Cobra venom, Russell's viper venom, Krait venom and Echis venom along with montanide adjuvants, IMS 3012, ISA 206, ISA 35 and Incomplete Freund's adjuvant as a control adjuvant; through subcutaneous route at intervals of two weeks. During the immunization period, biochemical and hematological parameters were monitored at 0th, 14th, 21st, 30th and 42nd weeks. The mean hemoglobin values dropped slightly during initial immunization but subsequently regained to normal levels. The mean serum total protein values and globulin levels showed an increment in all the four groups, compared to day zero, vice-versa a slight drop was observed in albumin levels. No significant changes were observed in serum creatinine, bilirubin, alkaline phosphatase and blood urea nitrogen values. Finally, we conclude that montanide adjuvants could be a safer alternative to the conventional adjuvants for primary phase of immunization in antivenom production. Copyright © 2014 Elsevier Ltd. All rights reserved.

Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections in a Chinese Children's Hospital: Predominance of New Delhi Metallo-β-Lactamase-1.

PubMed

Dong, Fang; Zhang, Ye; Yao, Kaihu; Lu, Jie; Guo, Lingyun; Lyu, Shuang; Yang, Ying; Wang, Yan; Zheng, Hongyan; Song, Wenqi; Liu, Gang

2018-03-01

The spread of carbapenem-resistant Klebsiella pneumoniae (CRKp) has become a significant problem worldwide; however, relevant data in children are limited. We performed a retrospective study to better understand the epidemiology of CRKp bloodstream infections at Beijing Children's Hospital. A total of 164 K. pneumoniae strains were collected from blood cultures between January 2011 and September 2014, of which 52 (31.7%) were CRKp strains. All 52 CRKp strains were multidrug resistant; 46 (88.5%) and 49 (94.2%) isolates were resistant to meropenem and imipenem, respectively. Low rates of resistance to amikacin (5.8%), levofloxacin (7.7%), and ciprofloxacin (15.4%) were observed. All isolates were susceptible to colistin. Among the tested carbapenem resistance genes, the predominant gene was bla NDM-1 , detected in 28 (53.8%) isolates, followed by bla IMP-4 (19, 36.5%) and bla KPC-2 (4, 7.7%). Multilocus sequence typing identified 31 sequence types (STs), the most predominant of which was ST782 (9, 29.0%). All ST782 strains were New Delhi metallo-β-lactamase-1 (NDM-1) producing. Four novel STs (ST2010, ST2011, ST2012, and ST2013) and two novel alleles (phoE243 and tonB324) were also detected. Hematologic disease was the most common underlying disease (73.1%). All children received initial empirical therapy. A total of 59.6% (31/52) patients received inappropriate empirical therapy, and 45.2% (14/31) changed antimicrobial therapy after blood culture results were obtained. The overall mortality rate was 11.5%. In conclusion, we observed a high rate of CRKp isolates collected from blood cultures and the predominance of NDM-1-producing K. pneumoniae among children from 2011 to 2014.

The U.S. Geological Survey Amphibian Research and Monitoring Initiative-2011 Annual Update

USGS Publications Warehouse

Adams, M.J.; Muths, E.; Grant, E.H.C.; Miller, David A.; Waddle, J.H.; Ball, L.C.

2012-01-01

Welcome to the inaugural issue of ARMI's Annual Update. This update provides highlights and significant milestones of this innovative program. ARMI is uniquely qualified to provide research and monitoring results that are scalable from local to national levels, and are useful to resource managers. ARMI has produced nearly 400 peer-reviewed publications, including 18 in 2011. Some of those publications are highlighted in this fact sheet. ARMI also has a new Website (armi.usgs.gov). You can now use it to explore an up-to-date list of ARMI products, to find summaries of research topics, to search for ARMI activities in your area, and to obtain amphibian photographs. ARMI's annual meeting was organized by Walt Sadinski, Upper Midwest Environmental Science Center, and held in St Louis, Missouri. We met with local scientists and managers in herpetology and were given a tour of the herpetology collection at the St. Louis Zoo.

78 FR 13576 - Special Local Regulations and Safety Zones; Recurring Marine Events and Fireworks Displays Within...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... area April--2nd Saturday St. Mary's College Seahawk Specified waters of St. Mary's Sprint River... regulations by adding 15 new annual recurring marine events, fireworks displays and revising event date(s) and... provide for the safety of life on navigable waters during these events, reduce the Coast Guard's...

GONADAL DEVELOPMENT AND ENDOCRINE RESPONSES IN JAPANESE MEDAKA (ORYZIAS LATIPES) EXPOSED TO O.P'-DDT IN WATER OR THROUGH MATERNAL TRANSFER

EPA Science Inventory

In: Environmental Sciences in the 21st Century: Paradigms, Opportunities, and Challenges: Abstract Book: SETAC 21st Annual Meeting, 12-16 November 2000, Nashville, TN. Society of Environmental Toxicology and Chemistry, Pensacola, FL. Pp. p. 262. (ERL,GB R816).

Various i...

Effect of Food, Diet and Nutrition on Military Readiness and Preparedness of Army Personnel and Dependents in a Peacetime Environment

DTIC Science & Technology

1991-08-15

Beckman Synchron CX5 automated clinical chemistry system; b. Coulter STKS automated hematology system with five part differential; c. Perkin Elmer P1000...500,000 of Pennington center funds were used to equip this laboratory. Progress on Method Development a. General Chemistry Most routine chemistry analyses...are performed on the Beckman Synchron CX5 automated chemistry system. A description of this system is given in the Second Annual Report, pg 8 (1

St. Louis Airport Site. Annual site environmental report, calendar year 1985. Formerly Utilized Sites Remedial Action Program (FUSRAP). Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-09-01

During 1985, the environmental monitoring program was continued at the St. Louis Airport Site (SLAPS) in St. Louis County, Missouri. The ditches north and south of the site have been designated for cleanup as part of the Formerly Utilized Sites Remedial Action Program (FUSRAP). The monitoring program at the SLAPS measures radon gas concentrations in air; external gamma radiation dose rates; and uranium, thorium, and radium concentrations in surface water, groundwater, and sediment. Potential radiation doses to the public are also calculated. Because the site is not controlled or regulated by the DOE, the DOE Derived Concentration Guides (DCGs) aremore » not applicable to SLAPS, but are included only as a basis for comparison. The DOE DCGs and the DOE radiation protection standard have been revised. (Appendix B). During 1985, annual average radon levels in air at the SLAPS were below the DCG for uncontrolled areas. External gamma monitoring in 1985 showed measured annual gamma dose rates ranging from 3 to 2087 mrem/y, with the highest value occurring in an area known to be contaminated. The calculated maximum dose at the site boundary, assuming limited occupancy, would be 6 mrem/y. Average annual concentrations of /sup 230/Th, /sup 226/Ra, and total uranium in surface waters remained below the DOE DCG. The on-site groundwater measurements showed that average annual concentrations of /sup 230/Th, /sup 226/Ra and total uranium were within the DOE DCGs. Although there are no DCGs for sediments, all concentrations of total uraniu, /sup 230/Th, and /sup 226/Ra were below the FUSRAP Guidelines.« less

Annual Report of the Council of the Association for the Year Ending 31st December, 1976.

ERIC Educational Resources Information Center

Library Association, London (England).

Topics summarized in this annual report of the Library Association for 1976 include improved contact between branch and headquarters staff; continued international relations; efforts to capture interests of groups and individuals outside the Library Association; public lending right, and economic cuts; closer liaison with people and organizations…

Withering Heights: 21st Annual Salary Survey.

ERIC Educational Resources Information Center

Schettler, Joel

2002-01-01

This report on an annual salary survey of trainers shows that, although training professionals' base salaries increased 7.1 percent over last year, their raises (3.9 percent) were not equal to those of the general public (4.5 percent). Tables depict salaries by region, gender, job category, industry, gross sales/assets, education, and experience.…

Proceedings of the Annual National Agricultural Education Research Meeting (9th, St, Louis, Missouri, December 3, 1982).

ERIC Educational Resources Information Center

American Vocational Association, Arlington, VA. Agricultural Education Div.

These proceedings contain the texts of 29 papers presented at the ninth Annual Agricultural Education Research Meeting. During the five sessions of the conference, various areas of agricultural education were addressed, such as inservice education, job satisfaction and morale, teacher concerns, national issues, program improvement, preservice…

Annual Report of New York State Interdepartmental Committee on Indian Affairs, 1971-1972.

ERIC Educational Resources Information Center

Hathorn, John R.

The New York State Interdepartmental Committee on American Indian Affairs renders, through the several state departments, various services to Indians located in the state. The Committee's 1971-72 Annual Report describes these services for the state's 8 Indian Reservations--Allegany, Cattaraugus, Onondaga, Poospatuck, St. Regis, Shinnecock,…

Annual Report of New York State Interdepartmental Committee on Indian Affairs, 1969-70.

ERIC Educational Resources Information Center

Hathorn, John R.

The 1969-70 annual report of the New York State Interdepartmental Committee on Indian Affairs describes the committee's purpose and function as being to render, through the several state departments and agencies represented, various services to the 8 Indian Reservations--Cattaraugus, St. Regis, Tonawanda, Tuscarora, Allegany, Anandaga, Shinnecock,…

Annual Report of New York State Interdepartmental Committee on Indian Affairs, 1970-71.

ERIC Educational Resources Information Center

Hathorn, John R.

The 1970-71 annual report of the New York State Interdepartmental Committee on Indian Affairs describes the committee's purpose and function as being to render, through the several state departments and agencies represented, various services to the 8 Indian Reservations--Cattaraugus, St. Regis, Tonawanda, Tuscarora, Allegany, Onandaga, Shinnecock,…

Mosquito vector biology and control in Latin America - A 25th Symposium

USDA-ARS?s Scientific Manuscript database

The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, for the previous 24 symposia, was to promote participation in the AMCA by vector control spec...

Missouri Annual Blind/Visually Impaired Literacy Study, December 2012

ERIC Educational Resources Information Center

Missouri Department of Elementary and Secondary Education, 2012

2012-01-01

The Missouri Department of Elementary and Secondary Education, per Section 162.1136 RSMo, conducts an annual study of the educational status of eligible blind/visually impaired students and reports the findings to the Missouri Legislature on December 1st each year. The information contained in this report pertains to the twelve data elements…

Missouri Annual Blind/Visually Impaired Literacy Study, December 2010

ERIC Educational Resources Information Center

Missouri Department of Elementary and Secondary Education, 2010

2010-01-01

The Missouri Department of Elementary and Secondary Education, per Section 162.1136 RSMo, conducts an annual study of the educational status of eligible blind/visually impaired students and reports the findings to the Missouri Legislature on December 1st each year. The information contained in this report pertains to the twelve data elements…

Missouri Annual Blind/Visually Impaired Literacy Study, December 2011

ERIC Educational Resources Information Center

Missouri Department of Elementary and Secondary Education, 2011

2011-01-01

The Missouri Department of Elementary and Secondary Education, per Section 162.1136 RSMo, conducts an annual study of the educational status of eligible blind/visually impaired students and reports the findings to the Missouri Legislature on December 1st each year. The information contained in this report pertains to the twelve data elements…

INTEGRATE: Driving Transformational Change - JISEA 2018 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

This report demonstrates 2017 highlights of the Joint Institute for Strategic Energy Analysis' (JISEA's) work. The Annual Report overviews JISEA's research and analysis accomplishments in natural gas and methane emissions; nuclear-renewable hybrid energy systems; the Clean Energy Manufacturing Analysis Center's work in global supply chains; the 21st Century Power Partnership; and more.

The business of palliative medicine--part 4: Potential impact of an acute-care palliative medicine inpatient unit in a tertiary care cancer center.

PubMed

Walsh, Declan

2004-01-01

In this study, a hematology/oncology computerized discharge database was qualitatively and quantitatively reviewed using an empirical methodology. The goal was to identify potential patients for admission to a planned acute-care, palliative medicine inpatient unit. Patients were identified by the International Classifications of Disease (ICD-9) codes. A large heterogenous population, comprising up to 40 percent of annual discharges from the Hematology/Oncology service, was identified. If management decided to add an acute-care, palliative medicine unit to the hospital, these are the patients who would benefit. The study predicted a significant change in patient profile, acuity, complexity, and resource utilization in current palliative care services. This study technique predicted the actual clinical load of the acute-care unit when it opened and was very helpful in program development. Our model predicted that 695 patients would be admitted to the acute-care palliative medicine unit in the first year of operation; 655 patients were actually admitted during this time.

Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1.

PubMed

Yan, Siyuan; Liu, Ling; Ren, Fengxia; Gao, Quan; Xu, Shanshan; Hou, Bolin; Wang, Yange; Jiang, Xuejun; Che, Yongsheng

2017-08-10

Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is limited in mammalian cells. Utilizing immunostaining and subcellular fractionation, we found that either LC3-II or the phosphorylated Ulk1 localized in nuclei, and immunoprecipitation results showed that both LC3 and Unc-51-like kinase 1 (Ulk1) interacted with γ-H2AX, a marker for the DNA double-strand breaks (DSB). Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor, was found to enhance the autophagic flux concurring with increase in the frequency of micronuclei accrued upon inhibition of autophagy, and similar results were also obtained in the rasfonin-treated cells. Moreover, the punctate LC3 staining colocalized with micronuclei. Unexpectedly, deprivation of SQSTM1/p62 alone accumulated micronuclei, which was not further increased upon challenge with ST. Rad51 is a protein central to repairing DSB by homologous recombination and treatment with ST or rasfonin decreased its expression. In several cell lines, p62 appeared in the immunoprecipites of Rad51, whereas LC3, Ulk1 and p62 interacted with PARP-1, another protein involved in DNA repair and genomic stability. In addition, knockdown of either Rad51 or PARP-1 completely inhibited the ST-induced autophagic flux. Taken together, the data presented here demonstrated that both LC3-II and the phosphorylated Ulk1 localized in nuclei and interacted with the proteins essential for nuclear stability, thereby revealing a more intimate relationship between autophagy and genomic stability.

Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1

PubMed Central

Yan, Siyuan; Liu, Ling; Ren, Fengxia; Gao, Quan; Xu, Shanshan; Hou, Bolin; Wang, Yange; Jiang, Xuejun; Che, Yongsheng

2017-01-01

Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is limited in mammalian cells. Utilizing immunostaining and subcellular fractionation, we found that either LC3-II or the phosphorylated Ulk1 localized in nuclei, and immunoprecipitation results showed that both LC3 and Unc-51-like kinase 1 (Ulk1) interacted with γ-H2AX, a marker for the DNA double-strand breaks (DSB). Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor, was found to enhance the autophagic flux concurring with increase in the frequency of micronuclei accrued upon inhibition of autophagy, and similar results were also obtained in the rasfonin-treated cells. Moreover, the punctate LC3 staining colocalized with micronuclei. Unexpectedly, deprivation of SQSTM1/p62 alone accumulated micronuclei, which was not further increased upon challenge with ST. Rad51 is a protein central to repairing DSB by homologous recombination and treatment with ST or rasfonin decreased its expression. In several cell lines, p62 appeared in the immunoprecipites of Rad51, whereas LC3, Ulk1 and p62 interacted with PARP-1, another protein involved in DNA repair and genomic stability. In addition, knockdown of either Rad51 or PARP-1 completely inhibited the ST-induced autophagic flux. Taken together, the data presented here demonstrated that both LC3-II and the phosphorylated Ulk1 localized in nuclei and interacted with the proteins essential for nuclear stability, thereby revealing a more intimate relationship between autophagy and genomic stability. PMID:28796254

12 CFR 327.52 - Annual dividend determination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the DIF reserve ratio as of December 31st of 2008 or any later year equals or exceeds 1.35 percent... dividend based upon the reserve ratio of the DIF as of December 31st of the preceding year, and the amount... ratio of the DIF equals or exceeds 1.35 percent of estimated insured deposits and does not exceed 1.50...

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (31st, Seoul, Korea, July 8-13, 2007). Volume 1

ERIC Educational Resources Information Center

Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik Park, Ed.; Seo, Dong-Yeop, Ed.

2007-01-01

The first volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents plenary lectures; research forums; discussion groups; working sessions; short oral communications; and posters from the meeting. Plenary lecture papers include: (1) On Humanistic Mathematics Education: A…

Warning: Dates on the Calendar Are Closer Than They Appear. 21st Century Challenges for Adult Educators.

ERIC Educational Resources Information Center

Mott, Vivian Wilson

1997-01-01

In October 1996, adult educators from throughout the world gathered in Charlotte, North Caroline, for the annual conference of the American Association for Adult and Continuing Education. The following challenges were identified as the four megachallenges facing adult education and adult educators at the dawning of the 21st century: advancing…

Reference intervals, longitudinal analyses, and index of individuality of commonly measured laboratory variables in captive bald eagles (Haliaeetus leucocephalus).

PubMed

Jones, Michael P; Arheart, Kristopher L; Cray, Carolyn

2014-06-01

The objectives of this study were to determine reference intervals, perform longitudinal analyses, and determine the index of individuality (IoI) of 8 hematologic, and 13 biochemical and electrophoretic variables for a group of captive bald eagles (Haliaeetus leucocephalus). Reference intervals were determined from blood samples collected during annual wellness examinations for 41 eagles (23 male and 18 female) with ages ranging between 6 and 43 years (18.7 +/- 7.4, mean +/- SD) at the time of sample collection. Longitudinal analyses and IoI were determined for measured hematologic, biochemical, and protein electrophoretic variables, both individually and as a group, for a subset of 16 eagles (10 male and 6 female) during a 12-year period. This smaller group of eagles ranged in age between 2 and 20 years at the start of the study period, and between 14 and 32 years (21.9 +/- 5.0, mean +/- SD) at the end of the study period. Significant increases with age within the group of 16 eagles were observed only for red blood cells, percent heterophils, total protein, and beta-globulin protein fraction, while albumin:globulin decreased significantly with age. A low IoI (> or = 1.4) was determined for all hematologic and biochemical variables except gamma globulins, which had high IoI (< or = 0.6) for 3 individuals within the subset of 16.

77 FR 69649 - Agency Information Collection Activities: Application-Permit-Special License Unlading-Lading...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... technology; and (e) the annual cost burden to respondents or record keepers from the collection of... Responses: 399,000. Estimated Time per Response: 8 minutes. Estimated Total Annual Burden Hours: 51,870...

Seasonal variation and annual trends of metals and metalloids in the blood of the Little Penguin (Eudyptula minor).

PubMed

Finger, Annett; Lavers, Jennifer L; Orbell, John D; Dann, Peter; Nugegoda, Dayanthi; Scarpaci, Carol

2016-09-15

Little Penguins (Eudyptula minor) are high-trophic coastal feeders and are effective indicators of bioavailable pollutants in their foraging zones. Here, we present concentrations of metals and metalloids in blood of 157 Little Penguins, collected over three years and during three distinct seasons (breeding, moulting and non-breeding) at two locations: the urban St Kilda colony and the semi-rural colony at Phillip Island, Victoria, Australia. Penguin metal concentrations were foremostly influenced by location (St Kilda>Phillip Island for non-essential elements) and differed among years and seasons at both locations, reflecting differences in seasonal metal bioaccumulation or seasonal exposure through prey. Mean blood mercury concentrations showed an increasing annual trend and a negative correlation with flipper length at St Kilda. Notably, this study is the first to report on blood metal concentrations during the different stages of moult, showing the mechanism of non-essential metal mobilisation and detoxification. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Study of the Climate Change during 21st Century over Peninsular Malaysia Watersheds

NASA Astrophysics Data System (ADS)

Kavvas, M. L.; Ercan, A.; Ishida, K.; Chen, Z. R.; Jang, S.; Amin, M. Z. M.; Shaaban, A. J.

2016-12-01

15 coarse-resolution (150 - 300 km) climate projections for the 21st century by 3 different coupled land-atmosphere-ocean GCMs (ECHAM5 of the Max Planck Institute of Meteorology of Germany, CCSM3 of the National Center for Atmospheric Research (NCAR) of the United States, and MRI-CGCM2.3.2 of the Meteorological Research Institute of Japan) under 4 different greenhouse gas emission scenarios (B1, A1B, A2, A1FI) were dynamically downscaled at hourly intervals by a regional hydro-climate model of Peninsular Malaysia (RegHCM-PM) that consisted of Regional Atmospheric Model MM5 that was coupled with WEHY watershed hydrology model over Peninsular Malaysia (PM), at the scale of the hillslopes of 13 selected watersheds (Batu Pahat, Johor, Muda, Kelang, Kelantan, Linggi, Muar, Pahang, Perak, Selangor, Dungun, Kemaman and Kuantan) and 12 selected intervening coastal regions in order to assess the impact of climate change on the climate conditions at the selected watersheds and coastal regions of PM. From the downscaled climate projections it can be concluded that the mean annual precipitation gradually increases toward the end of the 21st century over each of the 13 watersheds and the 12 coastal regions. The basin-average mean annual temperature increases in the range of 2.50C - 2.950C over PM during the 2010 -2100 period when compared to the 1970-2000 historical period. The ensemble average basin-average annual potential evapotranspiration increases gradually throughout the 21st century over all watersheds.

A reliable combination method to identification and typing of epidemic and endemic clones among clinical isolates of Acinetobacter baumannii.

PubMed

Piran, Arezoo; Shahcheraghi, Fereshteh; Solgi, Hamid; Rohani, Mahdi; Badmasti, Farzad

2017-10-01

The multi-drug resistant (MDR) Acinetobacter baumannii as an important nosocomial pathogen has emerged a global health concern in recent years. In this study, we applied three easier, faster, and cost-effective methods including PCR-based open reading frames (ORFs) typing, sequence typing of bla OXA-51-like and RAPD-PCR method to rapid typing of A. baumannii strains. Taken together in the present study the results of ORFs typing, PCR-sequencing of bla OXA-51-like genes and MLST sequence typing revealed there was a high prevalence (62%, 35/57) of ST2 as international and successful clone which detected among clinical isolates of multi-drug resistant A. baumannii with ORF pattern B and bla OXA-66 gene. Only 7% (4/57) of MDR isolates belonged to ST1 with ORF pattern A and bla OXA-69 gene. Interestingly, we detected singleton ST513 (32%, 18/57) that encoded bla OXA-90 and showed the ORF pattern H as previously isolated in Middle East. Moreover, our data showed RAPD-PCR method can detect divergent strains of the STs. The Cl-1, Cl-2, Cl-3, Cl-4, Cl-10, Cl-11, Cl-12, Cl-13 and Cl-14 belonged to ST2. While the Cl-6, Cl-7, Cl-8 and Cl-9 belonged to ST513. Only Cl-5 belonged to ST1. It seems that the combination of these methods have more discriminatory than any method separately and could be effectively applied to rapid detection of the clonal complex (CC) of A. baumannii strains without performing of MLST or PFGE. Copyright © 2017 Elsevier B.V. All rights reserved.

36 CFR 51.46 - May the Director determine that a concessioner has not operated satisfactorily after a prospectus...

Code of Federal Regulations, 2010 CFR

2010-07-01

... of an annual evaluation of a concessioner's performance may not occur until after the selection of the best proposal submitted in response to a prospectus, the Director will make an annual performance... performance evaluation. In the event the concessioner receives a second less than satisfactory annual...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beck, James B.

National Security Office (NSO) newsletter's main highlight is on the annual Strategic Weapons in the 21st Century that the Los Alamos and Lawrence Livermore National Laboratories host in Washington, DC.

47 CFR 1.1152 - Schedule of annual regulatory fees and filing locations for wireless radio services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... locations for wireless radio services. 1.1152 Section 1.1152 Telecommunication FEDERAL COMMUNICATIONS... Procedures for Payment § 1.1152 Schedule of annual regulatory fees and filing locations for wireless radio..., St. Louis, MO 63197-9000. General Mobile Radio Service (a) New, Renew/Mod (FCC 605 & 159) 5.00 FCC, P...

47 CFR 1.1152 - Schedule of annual regulatory fees and filing locations for wireless radio services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... locations for wireless radio services. 1.1152 Section 1.1152 Telecommunication FEDERAL COMMUNICATIONS... Procedures for Payment § 1.1152 Schedule of annual regulatory fees and filing locations for wireless radio..., P.O. Box 979097, St. Louis, MO 63197-9000. General Mobile Radio Service: (a) New, Renew/Mod (FCC 605...

47 CFR 1.1152 - Schedule of annual regulatory fees and filing locations for wireless radio services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... locations for wireless radio services. 1.1152 Section 1.1152 Telecommunication FEDERAL COMMUNICATIONS... Schedule of annual regulatory fees and filing locations for wireless radio services. Exclusive use services... (Electronic Filing) (FCC 601 & 159) 20.00 FCC,P.O. Box 979097,St. Louis, MO 63197-9000. General Mobile Radio...

47 CFR 1.1152 - Schedule of annual regulatory fees and filing locations for wireless radio services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... locations for wireless radio services. 1.1152 Section 1.1152 Telecommunication FEDERAL COMMUNICATIONS... Procedures for Payment § 1.1152 Schedule of annual regulatory fees and filing locations for wireless radio..., P.O. Box 979097, St. Louis, MO 63197-9000. General Mobile Radio Service (a) New, Renew/Mod (FCC 605...

Vulnerabilities and adaptive capacities of selected southwestern crops to climate change

USDA-ARS?s Scientific Manuscript database

By the middle of the 21st Century, maximum annual temperatures in the Southwest (SW) are expected to increase by 2-4 C with the highest increases occurring in the summer months of Jun-Aug. While annual precipitation may remain similar to 1971-2000 values, Mar-May precipitation in the SW may decline ...

Consumer Interests Annual. Volume 41. American Council on Consumer Interests Annual Conference (41st, Washington, D.C., March 15-18, 1995).

ERIC Educational Resources Information Center

Folk, Karen F., Ed.

This proceedings contains the texts of 5 invited papers and 28 refereed papers. The following are among the papers included: "Consumer Interest in the 1990's and Beyond" (Turner); "Esther Peterson and the Consumer Movement" (Galbraith); "The Public's Right to Government Information" (English); "Partnerships in…

Report of the Annual Vocational, Technical and Adult Educators' Conference (1st, Jacksonville, Florida, August 4-9, 1968).

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Technical and Adult Education.

This first annual conference had as its theme "People, Education, Business and Industry--Partners for Excellence." Major speeches for the general conference program included: (1) "Selling the American System to Americans," by K. McFarland, (2) "Projection for the 70's," by C.W. Proehl, (3) "How to Help…

21st Annual Spring Research Festival Highlights Science, Celebrates Collaboration | Poster

Cancer.gov

For two days at the annual Spring Research Festival, Fort Detrick was abuzz with scientific discussion as researchers and visitors from the site’s many resident government agencies and contractors gathered to share findings and recognize collaborative research. Each year, the festival focuses on intermural scientific work, as well as challenges and discoveries in the fight

--No Title--

Science.gov Websites

} ItemDescription Microsoft Windows XP Version 5.1 (Build 2600) Service Pack 3; ESRI ArcCatalog 9.3.1.3000 en Annual Student RPP 303-384-7278 nick.grue@nrel.gov Microsoft Windows XP Version 5.1 (Build 2600) Service Pack 3

Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats.

PubMed

Wang, Er Hui; Yu, Zhou; Hu, Jing; Xu, Hai Bin

2013-12-01

Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control. Copyright © 2013 Elsevier Ltd. All rights reserved.

Hematologic responses to hypobaric hyperoxia.

NASA Technical Reports Server (NTRS)

Larkin, E. C.; Adams, J. D.; Williams, W. T.; Duncan, D. M.

1972-01-01

Study of the effects of hypoxia, activity, and G forces on human hematopoiesis in an attempt to elucidate these phenomena more precisely. Eight subjects were exposed to an atmosphere of 100% O2 at 258 mm Hg for 30 days, and thereafter immediately exposed to transverse G forces, simulating the Gemini flights' reentry profile. All subjects displayed a significant continuous decline in red cell mass during the exposure period, as measured by the carbon monoxide-dilution method. The Cr51 method also indicated a decline in red blood corpuscle mass. The decrease in red cell mass was due to suppression of erythropoiesis and to hemolysis. After exposure to hyperoxia, all subjects exhibited elevated plasma hemoglobin levels, decreased reticulocyte counts, and decreased red cell survivals. CO production rates and urine erythropoietin levels were unchanged. Two hours after termination of exposure to hyperoxia, all subjects exhibited increased reticulocyte counts which were sustained for longer than two weeks. The progressive decrease in red cell mass was promptly arrested on return to ground level atmospheres. Within 116 days after exposure to hyperoxia, the hematologic parameters of all eight subjects had returned to control levels.

Hematological and hemorheological effects of air pollution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baskurt, O.K.; Levi, E.; Caglayan, S.

1990-07-01

Selected hematological parameters and erythrocyte deformability indexes for 16 young male military students were compared before and after a period of exposure to heavy pollution. These students lived in Ankara, which has a serious air pollution problem. The mean sulfur dioxide levels measured at a station proximal to the campus where the students lived were 188 micrograms/m3 and 201 micrograms/m3 during first and second measurements, respectively. During the period between the two measurements, the mean sulfur dioxide level was 292 micrograms/m3. Significant erythropoiesis was indicated by increased erythrocyte counts and hemoglobin and hematocrit levels. Methemoglobin percentage was increased to 2.37more » +/- 0.49% (mean +/- standard error) from 0.51 +/- 0.23%. Sulfhemoglobinemia was present in six subjects after the period of pollution, but it was not present in any student prior to this period. Significant increases in erythrocyte deformability indexes were observed after the period of pollution, i.e., from 1.13 +/- 0.01 to 1.21 +/0 0.02, implying that erythrocytes were less flexible, which might impair tissue perfusion.« less

Proceedings of the Annual Midwest Research-to-Practice Conference in Adult Continuing, and Community Education (18th, St. Louis, Missouri, September 22-24, 1999).

ERIC Educational Resources Information Center

Austin, Ann, Ed.; Hynes, Geraldine E., Ed.; Miller, Roxanne T., Ed.

This document contains the proceedings of a 1999 conference on adult, continuing, and community education held in St. Louis, Missouri. The following 39 papers are included: "Program Effectiveness Evaluation: Recertification and Job Upgrading for Adult Refugees" (Non-Native Speakers of English) (Adelman); "Rethinking the Linkages between Higher and…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (21st, Lahti, Finland, July 14-19, 1997). Volume 4.

ERIC Educational Resources Information Center

Pehkonen, Erkki, Ed.

The fourth volume of the proceedings of 21st annual meeting of the International Group for the Psychology of Mathematics Education contains the following papers: (1) "A Model for Discriminating amongst Student Teachers of Mathematics" (P. Perks); (2) "A Study of Teachers' Conceptions about Mathematics" (G.N. Philippou and C.…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (21st, Lahti, Finland, July 14-19, 1997). Volume 1.

ERIC Educational Resources Information Center

Pehkonen, Erkki, Ed.

The first volume of the proceedings of the 21st annual meeting of the International Group for the Psychology of Mathematics Education contains the following 13 full papers: (1) "Some Psychological Issues in the Assessment of Mathematical Performance" (O. Bjorkqvist); (2) "Neuromagnetic Approach in Cognitive Neuroscience" (S.…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (31st, Seoul, Korea, July 8-13, 2007). Volume 4

ERIC Educational Resources Information Center

Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik, Ed.; Seo, Dong-Yeop, Ed.

2007-01-01

This fourth and final volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents research reports for author surnames beginning Na- through Zod-. Reports include: (1) Mathematically Gifted Students' Problem Solving Approaches on Conditional Probability (GwiSoo Na, DaeHee Han,…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (21st, Lahti, Finland, July 14-19, 1997). Volume 3.

ERIC Educational Resources Information Center

Pehkonen, Erkki, Ed.

The third volume of the proceedings of 21st annual meeting of the International Group for the Psychology of Mathematics Education contains the following papers: (1) "Graphics Calculators Use in Precalculus and Achievement in Calculus" (P. Gomez and F. Femandez); (2) "Tapping into Algebraic Variables through the Graphic…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (31st, Seoul, Korea, July 8-13, 2007). Volume 3

ERIC Educational Resources Information Center

Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik Park, Ed.; Seo, Dong-Yeop, Ed.

2007-01-01

This third volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents research reports for author surnames beginning Han- through Miy-. Reports include: (1) Elementary Education Students' Memories of Mathematics in Family Context (Markku S. Hannula, Raimo Kaasila, Erkki…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (31st, Seoul, Korea, July 8-13, 2007). Volume 2

ERIC Educational Resources Information Center

Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik Park, Ed.; Seo, Dong-Yeop, Ed.

2007-01-01

This second volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents research reports for author surnames beginning Alc- through Hal-. Reports include: (1) How Do Your Students Think about Proof? A DVD Resource for Mathematicians (Lara Alcock); (2) Teachers' Conceptions of…

Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (21st, Lahti, Finland, July 14-19, 1997). Volume 2.

ERIC Educational Resources Information Center

Pehkonen, Erkki, Ed.

The second volume of the proceedings of 21st annual meeting of the International Group for the Psychology of Mathematics Education contains the following papers: (1) "The Dilemma of Transparency: Seeing and Seeing through Talk in the Mathematics Classroom" (J. Adler); (2) "Abstraction is Hard in Computer-Science Too" (D.…

Educational Accountability in the 21st Century. 2000 CRESST Conference Proceedings (Los Angeles, California, September 14-15, 2000). CSE Technical Report 549.

ERIC Educational Resources Information Center

Lewis, Anne

This report outlines the major themes of the 2000 annual conference of the Center for Research on Evaluation, Standards, and Student Testing (CRESST), which focused on educational accountability in the 21st century. The conference opened with a panel presentation on the Texas accountability system. This session included a presentation by one of…

Hemispheric Differences in the Annual Cycle of Tropical Lower Stratosphere Transport and Tracers

NASA Technical Reports Server (NTRS)

Tweedy, O. V.; Waugh, D. W.; Stolarski, R. S.; Oman, Luke D.; Randel, W. J.; Abalos, M.

2017-01-01

Transport in the tropical lower stratosphere plays a major role in determining the composition of the entire stratosphere. Previous studies that quantified the relative role of transport processes have generally assumed well-mixed tropics and focused on tropical-�wide average characteristics. However, it has recently been shown that there is a hemispheric difference in the annual cycle of tropical lower stratosphere ozone and other tracers, with a larger amplitude in the northern tropics (NT) than in the southern tropics (ST). In this study, we examined the ability of chemistry climate models (CCMs) to reproduce the hemispheric differences in ozone (O3) and other tracers (i.e., hydrochloric acid, or HCl and nitrous oxide, or N2O), and then use the CCMs to examine the cause of these differences. Examination of CCM simulations from the CCMVal-2 project shows that the majority of the CCMs produce the observed feature of a larger annual cycle in the NT than ST O3 and other tracers. However, only around a third of the models produce an ozone annual cycle similar to that observed. Transformed Eulerian Mean analysis of two of the CCMs shows that seasonality in vertical advection drives the seasonality in ST O3 and N2O while seasonality of horizontal mixing drives the seasonality in NT O3 and N2O, with a large increase in horizontal mixing during northern summer (associated with the Asian monsoon). Thus, latitudinal and longitudinal variations within the tropics have to be considered to fully understand the balance between transport processes in tropical lower stratosphere.

Studies on the erythron and the ferrokinetic responses in beagles adapted to hypergravity

NASA Technical Reports Server (NTRS)

Beckman, D. A.; Evans, J. W.; Oyama, J.

1978-01-01

Red cell survival, ferrokinetics, and hematologic parameters were investigated in beagle dogs exposed to chronic hypergravity (2.6 Gx). Ineffective erythropoiesis, red cell mass, plasma volume, and Cr-51-elution were significantly increased; maximum Fe-59 incorporation was decreased; and there was no change in the mean erythrocyte life span following autologous injection of Cr-51-labeled red cells and Fe-59-labeled transferrin. Red cell count, F(cells), total body hemoglobin (Hb), susceptability to osmotic lysis, and differential reticulocyte count were increased. White blood cell count, venous blood %Hb, mean cell volume, mean cell Hb, mean cell Hb concentration, and serum iron were decreased. No changes were observed for body mass, mg Fe per g Hb, iron binding capacity, percent saturation of iron carrying capacity, or the electrophoretic mobility of purified Hb. This study indicated that chronic exposure to hypergravity induced changes in red cell size, volume, total mass, and membrane permeability.

Occupational health risk of working in garages: comparative study on blood pressure and hematological parameters between garage workers and Haramaya University community, Harar, eastern Ethiopia.

PubMed

Ataro, Zerihun; Geremew, Abraham; Urgessa, Fekadu

2018-01-01

Occupational exposure to chemicals in garages causes a wide range of biological effects, depending upon the level and duration of exposure. In Ethiopia, there have been few studies conducted to assess the exposure of garage workers to chemicals. Preceding studies have not explored the effect of working in garage on blood pressure and hematological parameters. Therefore, this study aimed to assess differences in blood pressure and hematological parameters among garage workers compared to the Haramaya University community, Harar, eastern Ethiopia. A comparative cross-sectional study was conducted in Harar town, eastern Ethiopia. Thirty garage workers were selected and compared with 30 age- and sex-matched controls comprising of teachers and students. Demographic and occupational data were collected by using a structured questionnaire by a trained data collector. Blood pressure was measured using sphygmomanometry. Hematological parameters were measured with an automated hematology analyzer. Data were analyzed using Stata version 13. The majority of the garage workers did not implement effective preventive or control measures for workplace chemical exposure. Statistically significant increases were found in systolic (128.67±18.14 vs 106.33 ±9.27 mmHg, P <0.0001), diastolic blood pressure (90.33±11.29 vs 75.67 ±5.68 mmHg, P <0.0001), total white blood cells (7.9±1.51 vs 6.72±2.04×10 9 cells/L, P =0.0138), and platelets (323.20±48.82 vs 244.1±47.3×10 9 cells/L, P <0.0001) in garage workers compared to the control group. On the other hand, statistically significant decreases were found in red blood cells (5.13±0.38 vs 5.46±0.36×10 12 cells/L, P =0.0006), hemoglobin (14.89±0.71 vs 15.45±0.87 g/dL, P =0.0062), hematocrit (43.98%±1.99% vs 46.4%3±2.32%, P <0.0001), and mean corpuscular volume (83.19±2.93 vs 85.11±3.87 fL, P =0.0353) among garage workers compared to the control group. There were significant differences in blood pressure and hematological parameters between garage workers and the control group. Therefore, appropriate and effective safety measures need to be taken by the workers to prevent possible chemical exposure during routine tasks.

Occupational health risk of working in garages: comparative study on blood pressure and hematological parameters between garage workers and Haramaya University community, Harar, eastern Ethiopia

PubMed Central

Ataro, Zerihun; Geremew, Abraham; Urgessa, Fekadu

2018-01-01

Background Occupational exposure to chemicals in garages causes a wide range of biological effects, depending upon the level and duration of exposure. In Ethiopia, there have been few studies conducted to assess the exposure of garage workers to chemicals. Preceding studies have not explored the effect of working in garage on blood pressure and hematological parameters. Therefore, this study aimed to assess differences in blood pressure and hematological parameters among garage workers compared to the Haramaya University community, Harar, eastern Ethiopia. Materials and methods A comparative cross-sectional study was conducted in Harar town, eastern Ethiopia. Thirty garage workers were selected and compared with 30 age- and sex-matched controls comprising of teachers and students. Demographic and occupational data were collected by using a structured questionnaire by a trained data collector. Blood pressure was measured using sphygmomanometry. Hematological parameters were measured with an automated hematology analyzer. Data were analyzed using Stata version 13. Results The majority of the garage workers did not implement effective preventive or control measures for workplace chemical exposure. Statistically significant increases were found in systolic (128.67±18.14 vs 106.33 ±9.27 mmHg, P<0.0001), diastolic blood pressure (90.33±11.29 vs 75.67 ±5.68 mmHg, P<0.0001), total white blood cells (7.9±1.51 vs 6.72±2.04×109 cells/L, P=0.0138), and platelets (323.20±48.82 vs 244.1±47.3×109 cells/L, P<0.0001) in garage workers compared to the control group. On the other hand, statistically significant decreases were found in red blood cells (5.13±0.38 vs 5.46±0.36×1012 cells/L, P=0.0006), hemoglobin (14.89±0.71 vs 15.45±0.87 g/dL, P=0.0062), hematocrit (43.98%±1.99% vs 46.4%3±2.32%, P<0.0001), and mean corpuscular volume (83.19±2.93 vs 85.11±3.87 fL, P=0.0353) among garage workers compared to the control group. Conclusion There were significant differences in blood pressure and hematological parameters between garage workers and the control group. Therefore, appropriate and effective safety measures need to be taken by the workers to prevent possible chemical exposure during routine tasks. PMID:29559815

Proceedings of the 2007 Annual Meeting of the Canadian Mathematics Education Study Group = Actes de la Rencontre Annuelle 2007 du Groupe Canadien d'Etude en Didactique des Mathematiques (31st, Fredricton, New Brunswick, Canada, Jun 8-12, 2007)

ERIC Educational Resources Information Center

Liljedahl, Peter, Ed.

2008-01-01

This submission contains the Proceedings of the 2007 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at the University of New Brunswick in Fredricton, New Brunswick. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning.…

Theoretical Study of Topside Ionospheric Clutter

DTIC Science & Technology

1992-07-15

investigated. 4. References: Foster. J.C.. C. del Pozo. K. Groves, and J.-P. St. Maurice , Radar observations of the onlst of current drivenr instabilities... Clemmons , and F. S. Mozer, High-resolution sounding rocket observations of large-amplitude Alfvin waves, J. Geophys. Res., 95, 12157-12171, 1990. [51 Breit...equilibrium. Can. J. Phys., 38, 1114-1133, 1960. i16] Foster, J. C., C. del Pozo, K. Groves, and J.-P. St. Maurice , Radar observations of the onset of

There's no profiting from a joint venture misadventure.

PubMed

Herschman, Gary W

2004-10-01

In St. David's vs. IRS, a not-for-profit health system effectively challenged the IRS's determination that the system should be disqualified from tax exemption because it had entered a 50/50 joint venture with a for-profit system. The court decisions in St. David's, coupled with a recent IRS ruling, Revenue Ruling 2004-51, provide insight into how a not-for-profit hospital can structure such a joint venture to avoid jeopardizing its tax-exempt status.

Hypertension and hematologic parameters in a community near a uranium processing facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, Sara E., E-mail: swagner@uga.edu; Burch, James B.; South Carolina Statewide Cancer Prevention and Control Program, Columbia, SC

Background: Environmental uranium exposure originating as a byproduct of uranium processing can impact human health. The Fernald Feed Materials Production Center functioned as a uranium processing facility from 1951 to 1989, and potential health effects among residents living near this plant were investigated via the Fernald Medical Monitoring Program (FMMP). Methods: Data from 8216 adult FMMP participants were used to test the hypothesis that elevated uranium exposure was associated with indicators of hypertension or changes in hematologic parameters at entry into the program. A cumulative uranium exposure estimate, developed by FMMP investigators, was used to classify exposure. Systolic and diastolicmore » blood pressure and physician diagnoses were used to assess hypertension; and red blood cells, platelets, and white blood cell differential counts were used to characterize hematology. The relationship between uranium exposure and hypertension or hematologic parameters was evaluated using generalized linear models and quantile regression for continuous outcomes, and logistic regression or ordinal logistic regression for categorical outcomes, after adjustment for potential confounding factors. Results: Of 8216 adult FMMP participants 4187 (51%) had low cumulative uranium exposure, 1273 (15%) had moderate exposure, and 2756 (34%) were in the high (>0.50 Sievert) cumulative lifetime uranium exposure category. Participants with elevated uranium exposure had decreased white blood cell and lymphocyte counts and increased eosinophil counts. Female participants with higher uranium exposures had elevated systolic blood pressure compared to women with lower exposures. However, no exposure-related changes were observed in diastolic blood pressure or hypertension diagnoses among female or male participants. Conclusions: Results from this investigation suggest that residents in the vicinity of the Fernald plant with elevated exposure to uranium primarily via inhalation exhibited decreases in white blood cell counts, and small, though statistically significant, gender-specific alterations in systolic blood pressure at entry into the FMMP.« less

Runoff from small peatland watersheds

Treesearch

Roger R. Bay

1969-01-01

Runoff was measured on four forested bog watersheds in northern Minnesota for 5 years. The experimental basins ranged in size from 24 to 130 acres and included both organic and mineral soils. Annual runoff was not evenly distributed. Spring runoff, from the beginning of flow in late March to the 1 st of June, accounted for 66 % of total annual water yield. Summer and...

Annual Report of the Council of the Association for the Year Ending 31st December, 1973.

ERIC Educational Resources Information Center

Library Association, London (England).

Topics summarized in this annual report of the Library Association for 1973 include the advent of the British Library; effects of local government reorganization upon public libraries and their staffs; possible introduction of a public lending right; threat of VAT on books and journals, and effects on the Open University libraries; increased book…

Proceedings of the Annual Nebraska Aviation Education Association Conference (1st, Omaha, Nebraska, January 1994). The UNO Aviation Monograph Series.

ERIC Educational Resources Information Center

Crehan, James E., Ed.

This collection of six papers constitutes the proceedings of the First Annual Conference of the Nebraska Aviation Education Association. These papers present many issues that the discipline of aviation is confronting, including those related to the aviation industry. The papers included are as follows: (1) "Using the DAT for Selection of…

76 FR 15892 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... [mu]g/m\\3\\ for all missing data in 1st quarter of 2008. \\4\\ Macon SE Annual Mean considers data...; Georgia: Macon; Determination of Attaining Data for the 1997 Annual Fine Particulate Standards AGENCY... air monitoring data for the 2007-2009 period showing that the Area has monitored attainment of the...

North East Association for Institutional Research Annual Conference Proceedings (29th, Annapolis, Maryland, November 16-19, 2002).

ERIC Educational Resources Information Center

North East Association for Institutional Research.

This proceedings contains papers from the 2002 annual conference of the Northeast Association for Institutional Research, a meeting devoted to assessment in the 21st century and the challenges that face institutional research. The papers are: (1) "Putting Community College Enrollment Trends in Perspective by the Use of Census Data and Market…

41st Annual Survey Report on State-Sponsored Student Financial Aid, 2009-2010 Academic Year

ERIC Educational Resources Information Center

National Association of State Student Grant and Aid Programs, 2010

2010-01-01

Each year, the National Association of State Student Grant and Aid Programs (NASSGAP) completes a survey regarding state-funded expenditures for postsecondary student financial aid. This report, the 41th annual survey, represents data from academic year 2009-10. Data highlights include: (1) In the 2009-2010 academic year, the states awarded about…

Chapter One in Ohio: Education Consolidation and Improvement Act. 21st Annual Evaluation Report, Fiscal 1986.

ERIC Educational Resources Information Center

Young, Eileen, Ed.

Recent activities provided in Ohio through Chapter 1 of the Education Consolidation and Improvement Act and its predecessor, Title I of the Elementary and Secondary Education Act are summarized in this annual report. Specific information contained in the report includes statistics for fiscal 1986 (the 1985-86 school year and the summer that…

Setting the Stage for the 21st Century. Chancellor's Annual Report, 1996-97. Positioning the Alabama College System for the Future.

ERIC Educational Resources Information Center

Gainous, Fred

The Chancellor's Annual Report 1996-97 outlines the recent accomplishments and future goals of the Alabama College System. The report also describes recent mergers and consolidations in the Alabama College System, and its projected fiscal future. Accomplishments fell into two major categories: teaching and learning improvement and workforce…

Recent Work in Roman Satire (1962-68)

ERIC Educational Resources Information Center

Anderson, William S.

1970-01-01

Initial phase of a literary review of books and articles on satire in Roman literature (the 51st in the "Classical World surveys). The review continues in "Classical World, March 1970, pages 217-222. (DS)

Towards the 21st Century: Books and Media for the Millennium. Selected Papers from the Annual Conference, International Association of School Librarianship (21st, Belfast, Northern Ireland, July 20-24, 1992).

ERIC Educational Resources Information Center

International Association of School Librarianship, Kalamazoo, MI.

This collection contains 13 selected papers presented at the 1992 conference of the International Association of School Librarianship. Titles are as follows: (1) "The Difference of Literature: Writing for the Future of Young Adults" (Aidan Chambers); (2) "Managing School Library Change" (Peggy Heeks); (3) "The Power of…

Mid-21st- century climate changes increase predicted fire occurrence and fire season length, Northern Rocky Mountains, United States

Treesearch

Karin L. Riley; Rachel A. Loehman

2016-01-01

Climate changes are expected to increase fire frequency, fire season length, and cumulative area burned in the western United States. We focus on the potential impact of mid-21st- century climate changes on annual burn probability, fire season length, and large fire characteristics including number and size for a study area in the Northern Rocky Mountains....

JPRS Report, Science & Technology, Japan, 1989 S&T Agency Annual 33

DTIC Science & Technology

1991-01-10

enter- prises are being put into operation. 46 JPRS-JST-91-001 10 January 1991 Shizuoka Prefecture, the Toyama Prefecture and Ishikawa Prefecture...Technology Agency, Ishikawa Prefecture "Topics in 21st-Century-Oriented Science and Technology Promotion in Ishikawa Prefecture" 200 people (From...Shiga Atomic Energy Ooi3 Ikata3 Genkai Atomic Energy 3 Shizuoka Prefecture, Oryu District, Hamaoka Town Ishikawa Prefecture, Hanesa District

Annual Report of the Chief of Engineers, U.S. Army, on Civil Works Activities 1960. Volume 1

DTIC Science & Technology

1960-01-01

M artin, Colo_._....... ........... .... Lookout Point, Oreg . . . . .. .. ... Lucky Peak, Idaho ... . . -- ... Pine Flat, Calif...2 Barren , Ky M-------------- ar 60 1964 Do. Princeton, W. Va---------- ------ Mar 60 1961 Local protection. Proctor, Tex------------------- Jun 60...Arkansas River crested at Pine Bluff, Ark., in October 1959 at a stage of 25 feet, about 1 foot above flood stage. The St. Francis River crested at St

Policies for managing urban growth and landscape change: a key to conservation in the 21st century

Treesearch

David N., tech. ed. Bengston

2005-01-01

Protecting natural areas in the face of urbanization is one of the most important challenges for conservation in the 21st century. The papers in this collection examine key issues related to growth management and selected approaches to managing urban growth and minimizing its social and environmental costs. They were presented at the 2004 annual meeting of the Society...

Department of Defense Chemical and Biological Defense Program. Annual Report to Congress

DTIC Science & Technology

2008-05-01

defense system acquisition costs through collaboration in the areas of development, production , and support, and to enhance interoperability with...security area leverages S&T efforts of the other product areas. Where unmet requirements are identified and where S&T is required to meet cost ...Defense Program Inventory Requirements The industrial base, which has scaled down since the end of the Cold War, has stabilized. Ongoing military

Predicting Significant Factors of Selective Marine Corps Reserve Marines’ Career Decisions in Response to the Force Structure Review

DTIC Science & Technology

2014-03-01

1st class and Not CFT 1st class in the final model, as shown in Table 16. A Marine is required to qualify annually with the M16 -A2 service rifle... M16 -A4 service rifle, or the M4 carbine. MCO 3574.2K identifies the requirements for qualification, scoring, and administrative matters pertaining to

The Metropolitan Life Survey of the American Teacher, 2000: Are We Preparing Students for the 21st Century?

ERIC Educational Resources Information Center

Axelrod, Anne; Markow, Dana

2000-01-01

"The Metropolitan Life Survey of the American Teacher, 2000: Are We Preparing Students for the 21st Century?" examines teachers', students', and parents' views on where students are headed and how prepared they will be to reach their future goals. This report is part of an annual series of national surveys conducted since 1984 for MetLife by…

St. Kitts and Nevis.

PubMed

1989-11-01

St. Kitts and Nevis have areas of 68 and 36 square miles respectively and the terrain is mountainous. The population is 45,800 total and the annual growth rate is .2%. The ethnic make up is almost all black African with some British, Portuguese, and Lebanese. The religions are primarily Anglican, with evangelical Protestant and Catholic minorities. Infant mortality stands at 41/1000. The government is a constitutional monarchy with a Westminster type parliament. There is a governor, a prime minister, a cabinet, an 11 -member appointed upper house and a 11- member elected house of representatives. The gross national product is $83 million and the annual growth rate is 4.6%. There are no natural resources, and agricultural products include sugarcane, cotton, peanuts, and vegetables. Industry is made up of manufacturing 12.9%, transport and communications 13%, construction 9.1% and hotels and restaurants 4.5%. The Federation of St. Kitts and Nevis became independent in 1983. The government diversified the agriculture by planting other crops than sugar, producing gelled ethanol, and developing a cane spirits liquor. Tourism has grown the most and in 1987 passed sugar as the main source of income. International aid will assist in finishing a road that will open the southeast area of St. Kitts for construction of hotels, where some of the best beaches are located.

The frequency of and associations with hospitalization secondary to lupus flares from the 1000 Faces of Lupus Canadian cohort.

PubMed

Lee, J; Peschken, C A; Muangchan, C; Silverman, E; Pineau, C; Smith, C D; Arbillaga, H; Zummer, M; Clarke, A; Bernatsky, S; Hudson, M; Hitchon, C; Fortin, P R; Pope, J E

2013-11-01

Hospitalization is a major factor in health care costs and a surrogate for worse outcomes in chronic disease. The aim of this study was to determine the frequency of hospitalization secondary to lupus flare, the causes of hospitalization, and to determine risk factors for hospitalization in patients with systemic lupus erythematosus (SLE). Data were collected as part of the 1000 Canadian Faces of Lupus, a prospective cohort study, where annual major lupus flares including hospitalizations were recorded over a 3-year period. Of 665 patients with available hospitalization histories, 68 reported hospitalization related to a SLE flare over 3 years of follow-up. The average annual hospitalization rate was 7.6% (range 6.6-8.9%). The most common reasons for hospitalization were: hematologic (22.1%), serositis (20.6%), musculoskeletal (MSK) (16.2%), and renal (14.7%). Univariate risk factors for lupus hospitalization included (OR [95% CI]; p < 0.05): juvenile-onset lupus (2.2 [1.1-4.7]), number of ACR SLE criteria (1.4 [1.1-1.7], baseline body mass index (BMI) (1.1 [1.0-1.1]), psychosis (3.4 [1.2-9.9]), aboriginal race (3.2 [1.5-6.7]), anti-Smith (2.6 [1.2-5.4]), erythrocyte sedimentation rate >25 mm/hr (1.9 [1.1-3.4]), proteinuria >0.5 g/d (4.2 [1.9-9.3], and SLAM-2 score (1.1 [1.0-1.2]). After multivariate regression only BMI, number of ACR criteria, and psychosis were associated with hospitalization for lupus flare. The mean annual rate of hospitalization attributed to lupus was lower than expected. Hematologic, serositis, MSK and renal were the most common reasons. In a regression model elevated BMI, more ACR criteria and psychosis were associated with hospitalization.

Long-Term Trends in Hematological and Nutritional Status After Gastrectomy for Gastric Cancer.

PubMed

Kim, Ji-Hyun; Bae, You-Jin; Jun, Kyong-Hwa; Chin, Hyung-Min

2017-08-01

This study investigated long-term trends in hematological and nutritional parameters after gastrectomy for gastric cancer and evaluated the influence of the reconstruction type on these trends. The medical records of 558 patients who underwent curative gastrectomy with standard lymph node dissection for stage I gastric cancer between January 2006 and December 2013 were reviewed. The hematological and nutritional parameters evaluated included hemoglobin, ferritin, vitamin B 12 , total protein, albumin, total cholesterol, triglyceride, and calcium. The patients were followed up for 6 months postoperatively and then annually until death, cancer recurrence, or follow-up loss. In the long term, ferritin and triglyceride gradually decreased after gastrectomy, while the other parameters decreased slightly or were stable. In the comparisons according to reconstruction type, the Roux-en-Y group had the lowest levels of hemoglobin, ferritin, vitamin B12, total protein, albumin, and total cholesterol beginning 6 months postoperatively compared with the Billroth I and II groups. However, only ferritin and vitamin B 12 had significant differences in the 5-year cumulative incidences of deficiency/reduction according to the reconstruction type, whereas albumin, triglyceride, total cholesterol, and calcium did not. Although malabsorption and malnutrition are common in patients after a gastrectomy, most nutritional parameters were stable or decreased slightly in the long-term and were not markedly influenced by the reconstruction type or extent of gastrectomy. Therefore, for more accurate nutritional assessment after gastrectomy, multidirectional monitoring should be considered rather than simply measuring biochemical parameters.

Recent Work in Roman Satire (1962-1968)

ERIC Educational Resources Information Center

Anderson, William S.

1970-01-01

Continuation of a literary review of books and articles on satire in Roman literature (the 51st in the "Classical World surveys). The initial phase of the review appeared in "Classical World, February 1970, pages 181-199. (DS)

Calculating the affordability of antiretrovirals in St Lucia.

PubMed

Reddock, J R; Grignon, M

2013-01-01

The cost of antiretrovirals is borne by donors in many low- and middle-income countries, including St Lucia. Although donor involvement has facilitated access to antiretrovirals, donor engagement in HIV/AIDS has changed over the years. This paper assesses the affordability of antiretrovirals at the individual level if donors were no longer available to fund the cost of first and second-line antiretrovirals and a prospective third-line regimen. Various conceptions of affordability are reviewed using different assumptions of what is required to maintain a standard of living that would avoid individuals descending into poverty as a result of antiretroviral purchases. These concepts of affordability are operationalized using data from the Household Budgeting Survey conducted in St Lucia in 2005/2006. While there is a range of results for the affordability of first and second-line antiretrovirals depending on which standard of affordability is used, third-line antiretrovirals are unaffordable to more than 80% of the population across the four standards of affordability used - the national poverty line, 50% of median annual consumption, 10% of annual consumption and a proposed reasonable minimum standard.

Two models for microsimulation of family life cycle and family structure.

PubMed

Bertino, S; Pinnelli, A; Vichi, M

1988-01-01

2 models are proposed for the microsimulation of the family and analysis of family structure and life cycle. These models were devised primarily for teaching purposes. The families are composed of 3 generations (parents, grandparents, children). Cohabitation is not considered. The 1st model is governed by a transition mechanism based on the rules of a Markov multidimensional, nonhonogeneous chain. The 2nd model is based on stochastic point processes. Input data comprise annual mortality probability according to 1) sex, 2) age, 3) civil status, 4) annual probability of 1st marriage, 5) age combinations between the spouses, and 6) the probability of having 1, 2, or 3 children at 6 months intervals from the previous event (marriage or birth of nth child). The applications of the 1st model are presented using 2 mortality and fertility hypotheses (high and low) and a nuptiality hypothesis (West European nature). The various features of family composition are analyzed according to the duration of a couple's marriage and the age of the individual, as well as the characteristic features of the individual and family life cycle given these 2 demographic conditions.

Thinking about Thinking. Proceedings of the Annual Meeting of the South Atlantic Philosophy of Education Society (31st, Baltimore, Maryland, October 10-11, 1986).

ERIC Educational Resources Information Center

Craver, Samuel M., Ed.

The following papers (with authors and respondents) were presented at the annual conference of the South Atlantic Philosophy of Education Society: (1) "Teaching Critical Thinking through the Disciplines: Content Versus Process" (John E. McPeck) Respondent--Kingsley Price; (2) "Philosophy for Children and the Critical Thinking Movement" (Robert J.…

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools, 2013-2014

ERIC Educational Resources Information Center

Oregon Department of Education, 2014

2014-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools, 2011-2012

ERIC Educational Resources Information Center

Oregon Department of Education, 2012

2012-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Statewide Report Card: An Annual Report to the Legislature on Oregon Public Schools; 2015-2016

ERIC Educational Resources Information Center

Oregon Department of Education, 2016

2016-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Dreams and Dynamics. Selected Papers from the Annual Conference of the International Association of School Librarianship (22nd, Adelaide, South Australia, Australia, September 27-30, 1993).

ERIC Educational Resources Information Center

Hannesdottir, Sigrun Klara, Ed.; And Others

The themes of the 22nd Annual International Association of School Librarianship conference were: "Building a Picture of Society in the Year 2000"; "Literature--Themes of the '90s Towards the Future"; "Education--Partnerships To Develop Life-Long Learners"; and "Technology into the 21st Century." The…

Clinical Investigation Program.

DTIC Science & Technology

1981-10-01

Tomographic (CT) Appearance of the ryc- cardium After Neversible and Irreversible Ischemic Injury . 29th Annual Meeting of the Association of University...Orthopedic Surgeons, San Antonio, TX, Nov 1980. (C) Greenfield, G. Q., Jr.: Injuries Related to Rollerskating. Annual Mleeting, Society of Military...volume reduction odiumw balance A c-umuatie-.EDLASE I E st Ac cumul a ti ye Perio -di-c ............ Lost: LOA Cost: $1LO0. Review Results: Continue

Education of the Early Adolescent with Behavioral Disorders. Proceedings for the Annual Nebraska Symposium on Current Issues (1st, Omaha, Nebraska, May 9-11, 1979).

ERIC Educational Resources Information Center

Eyde, Donna R., Ed.; And Others

The collection of 12 papers from the 1979 First Annual Nebraska Symposium focuses on the problem of educating the secondary school aged disturbed student. Entries include the following titles and authors: "Issues in Diagnosis and Programming for Socio-Emotionally Impaired Early Adolescents" (W. Morse); "Adolescent Behavior--The…

A Call to Consciousness: Continuing Education for a Global Perspective. Proceedings of the Annual Meeting (55th, Jackson, Mississippi, October 17-19, 1993).

ERIC Educational Resources Information Center

Boyd, Donna J., Ed.

These proceedings record the addresses, concurrent sessions, and business meetings of the annual meeting of the Association for Continuing Higher Education (ACHE). Part 1 consists of three addresses: "World Collaboration for a Global Perspective" (Beverly Cassara); "When Chaos Is the Solution: A Paradigm for 21st Century Mandates and Strategies"…

An Annual Report to the Legislature on Oregon Public Schools. Oregon Statewide Report Card. 2014-2015

ERIC Educational Resources Information Center

Oregon Department of Education, 2015

2015-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

Life Long Learning: Rhetoric or Reality? Proceedings of the Annual Meeting, Association for Continuing Higher Education (41st, Toronto, Canada, November 4-8, 1979).

ERIC Educational Resources Information Center

Meeker, Josephine P., Ed.

Proceedings of the 1979 annual meeting of the Association for Continuing Higher Education concerning the topic of lifelong learning are presented. The past, present, and future of lifelong learning and the adult learner were considered in addresses and discussion. Workshops addressed the following areas: integration and development of adjuncts…

Declining rates of sterilisation reversal procedures in western Australian women from 1990 to 2008: the relationship with age, hospital type and government policy changes.

PubMed

Jama-Alol, Khadra A; Bremner, Alexandra P; Pereira, Gavin; Stewart, Louise M; Malacova, Eva; Moorin, Rachael; Preen, David B

2017-11-25

Female sterilisation is usually performed on an elective basis at perceived family completion, however, around 1-3% of women who have undergone sterilisation elect to undergo sterilisation reversal (SR) at a later stage. The trends in SR rates in Western Australia (WA), proportions of SR procedures between hospital types (public and private), and the effects of Federal Government policies on these trends are unknown. Using records from statutory state-wide data collections of hospital separations and births, we conducted a retrospective descriptive study of all women aged 15-49 years who underwent a SR procedure during the period 1st January 1990 to 31st December 2008 (n = 1868 procedures). From 1991 to 2007 the annual incidence rate of SR procedures per 10,000 women declined from 47.0 to 3.6. Logistic regression modelling showed that from 1997 to 2001 the odds of women undergoing SR in a private hospital as opposed to all other hospitals were 1.39 times higher (95% CI 1.07-1.81) and 7.51 times higher (95% CI 5.46-10.31) from 2002 to 2008. There were significant decreases in SR rates overall and among different age groups after the Federal Government interventions. Rates of SR procedures in WA have declined from 1990 to 2008, particularly following policy changes such as the introduction of private health insurance (PHI) policies. This suggests decisions to undergo SR may be influenced by Federal Government interventions.

Prevalence and factors associated with body mass index in children aged 9-11 years.

PubMed

Ferrari, Gerson Luis de Moraes; Matsudo, Victor; Katzmarzyk, Peter T; Fisberg, Mauro

This study aimed to identify the prevalence and factors associated with body mass index (BMI) in children aged 9-11 years. The study is part of the International Study of Childhood Obesity Lifestyle and the Environment (ISCOLE). Body composition was determined using the bipolar bioimpedance technique. The mean BMI value was categorized as recommended by the World Health Organization. For seven consecutive days, participants used an accelerometer to objectively monitor sedentary behavior (SB) and moderate to vigorous physical activity. Individual factors (anthropometric and behavioral), family aspects, and family and school environment were provided by participants and parents and were analyzed by multilevel linear regression adjusted for gender, ethnicity, school, number of siblings, and total annual family income. The mean BMI was 20.1kg/m 2 , and 51.8% of the children were overweight/obese (50.3% boys, 53.4% girls, p=0.014). Considering all participants, the associated factors of BMI were body fat percentage (BF%, β=0.0216, p<0.001) and screen time (ST, β=0.0050, p=0.006). In boys, the associated factors were BF% (β=0.0209, p<0.001), ST (β=0.006, p=0.036), and healthy eating policies or practices (β=0.0276, p=0.025). In girls, only BF% was associated (β=0.0221, p<0.001) with BMI. High prevalence of overweight/obesity was observed in children from São Caetano do Sul. Different associated factors were identified between the genders, with only BF% being common in both genders. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Developing a 21st Century Engineering Workforce

DTIC Science & Technology

2011-10-06

Developing a 21st Century Engineering Workforce Mr. Nicholas M. Torelli Director, Mission Assurance, ODASD(SE) 6 October 2011 Annual SERC Research...STATEMENT A -- Cleared for public release by OSR on 05 October 2011 -- SR case number 11-S-3744 applies A major thrust of the SERC is academic research...Technical Leadership   RT–16 Experience Accelerator   RT-19& 19A SE Capstone Courses SERC Research Provides Learning Resources ASRR 10

Multiscale Modeling and Process Optimization for Engineered Microstructural Complexity

DTIC Science & Technology

2007-10-26

R. C. Rogan, E. Üstündag, M. R. Daymond and V. Knoblauch Ferroelastic Behavior of PZT -Based Ferroelectric Ceramics , Materials Science Forum, 404...Bhattacharya, Materials Science Seminar, University of Southern California, 2003. 42. R.C. Rogan, Texture and Strain Analysis of PZT by In-Situ...Annual Meeting of the American Ceramic Society, St. Louis, MO; May 2002. 44. R. Rogan, Ferroelastic Behavior of PZT -Based Ferroelectric Ceramics , 6th

Incidence and survival of hematological cancers among adults ages ≥75 years.

PubMed

Krok-Schoen, Jessica L; Fisher, James L; Stephens, Julie A; Mims, Alice; Ayyappan, Sabarish; Woyach, Jennifer A; Rosko, Ashley E

2018-04-13

Evaluating population-based data of hematologic malignancies (HMs) in older adults provides prognostic information for this growing demographic. Incidence rates and one- and five-year relative survival rates were examined for specific HMs among adults ages ≥75 years using data from the Surveillance, Epidemiology and End Results (SEER) Program. Hematologic malignancy cases (Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), multiple myeloma (MM), acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML)) were reported to one of 18 SEER registries. Recent average annual (2010-2014) incidence rates and incidence trends from 1973 to 2014 were examined for cases ages ≥75 years. One- and five-year relative cancer survival rates were examined for adults ages ≥75 years diagnosed 2007-2013, with follow-up into 2014. From 1973 to 2014, incidence rates increased for NHL, MM, and AML, decreased for HL, and remained relatively stable for ALL, CLL, and CML among adults ages ≥75 years. The highest one- and five-year relative survival rates were observed among adults with CLL ages 75-84 years (1 year: 91.8% (95% CI = 91.8-90.8)) and 5 years: 76.5% (95% CI = 74.2-78.6)). The lowest one- and five-year survival rates were observed among adults with AML ages 75-84 (1 year: 18.2% (95% CI = 74.2-78.6) and 5 years: 2.7% (95% CI = 2.0-3.6)). Survival for older adults ages ≥75 years with HMs is poor, particularly for acute leukemia. Understanding the heterogeneity in HM outcomes among older patients may help clinicians better address the hematological cancer burden and mortality in the aging population. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Trends in Arctic Ocean bottom pressure, sea surface height and freshwater content using GRACE and the ice-ocean model PIOMAS from 2008-2012

NASA Astrophysics Data System (ADS)

Peralta-Ferriz, Cecilia; Morison, James; Zhang, Jinlun; Bonin, Jennifer

2014-05-01

The variability of ocean bottom pressure (OBP) in the Arctic is dominated by the variations in sea surface height (SSH) from daily to monthly timescales. Conversely, OBP variability is dominated by the changes in the steric pressure (StP) at inter-annual timescales, particularly off the continental shelves. The combination of GRACE-derived ocean bottom pressure and ICESat altimetry-derived sea surface height variations in the Arctic Ocean have provided new means of identifying inter-annual trends in StP (StP = OBP-SSH) and associated freshwater content (FWC) of the Arctic region (Morison et al., 2012). Morison et al. (2012) showed that from 2004 to 2008, the FWC increased in the Beaufort Gyre and decreased in the Siberian and Central Arctic, resulting in a relatively small net basin-averaged FWC change. In this work, we investigate the inter-annual trends from 2008 to 2012 in OBP from GRACE, SSH from the state-of-the-art pan-Arctic ocean model PIOMAS -validated with tide and pressure gauges in the Arctic-, and compute the trends in StP and FWC from 2008-2012. We compare these results with the previous trends from 2005-2008 described in Morison et al. (2012). Our initial findings suggest increased salinity in the entire Arctic basin (relative to the climatological seasonal variation) from 2008-2012, compared to the preceding four years (2005-2008). We also find that the trends in OBP, SSH and StP from 2008-2012 present a different behavior during the spring-summer and fall-winter, unlike 2005-2008, in which the trends were generally consistent through all months of the year. It seems since 2009, when the Beaufort Gyre relaxed and the export of freshwater from the Canada Basin into the Canadian Archipelago and Fram Strait, via the Lincoln Sea, was anomalously large (de Steur et al., 2013), the Arctic Ocean has entered a new circulation regime. The causes of such changes in the inter-annual trends of OBP, SSH and StP -hence FWC-, associated with the changes in the shape and strength of the Arctic Oscillation (AO) and the wind patterns, as well as with the changes in sea ice conditions will be explored. References: Morison, J., R. Kwok, C. Peralta-Ferriz, M. Alkire, I. Rigor, R. Andersen, and M. Steele, Changing Arctic Ocean Freshwater Pathways Measured With ICESat and GRACE, Nature, 481, 66-70, DOI: 10.1038/nature10705, 2012. de Steur, L., et al. (2013), Hydrographic changes in the Lincoln Sea in the Arctic Ocean with focus on an upper ocean freshwater anomaly between 2007 and 2010, J. Geophys. Res. Oceans, 118, 4699-4715, doi:10.1002/jgrc.20341.

Long-term prognostic value of a comprehensive assessment of cardiac magnetic resonance indexes after an ST-segment elevation myocardial infarction.

PubMed

Merlos, Pilar; López-Lereu, Maria P; Monmeneu, Jose V; Sanchis, Juan; Núñez, Julio; Bonanad, Clara; Valero, Ernesto; Miñana, Gema; Chaustre, Fabián; Gómez, Cristina; Oltra, Ricardo; Palacios, Lorena; Bosch, Maria J; Navarro, Vicente; Llácer, Angel; Chorro, Francisco J; Bodí, Vicente

2013-08-01

A variety of cardiac magnetic resonance indexes predict mid-term prognosis in ST-segment elevation myocardial infarction patients. The extent of transmural necrosis permits simple and accurate prediction of systolic recovery. However, its long-term prognostic value beyond a comprehensive clinical and cardiac magnetic resonance evaluation is unknown. We hypothesized that a simple semiquantitative assessment of the extent of transmural necrosis is the best resonance index to predict long-term outcome soon after a first ST-segment elevation myocardial infarction. One week after a first ST-segment elevation myocardial infarction we carried out a comprehensive quantification of several resonance parameters in 206 consecutive patients. A semiquantitative assessment (altered number of segments in the 17-segment model) of edema, baseline and post-dobutamine wall motion abnormalities, first pass perfusion, microvascular obstruction, and the extent of transmural necrosis was also performed. During follow-up (median 51 months), 29 patients suffered a major adverse cardiac event (8 cardiac deaths, 11 nonfatal myocardial infarctions, and 10 readmissions for heart failure). Major cardiac events were associated with more severely altered quantitative and semiquantitative resonance indexes. After a comprehensive multivariate adjustment, the extent of transmural necrosis was the only resonance index independently related to the major cardiac event rate (hazard ratio=1.34 [1.19-1.51] per each additional segment displaying>50% transmural necrosis, P<.001). A simple and non-time consuming semiquantitative analysis of the extent of transmural necrosis is the most powerful cardiac magnetic resonance index to predict long-term outcome soon after a first ST-segment elevation myocardial infarction. Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

Systematic review and benchmarking of Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) in oncology.

PubMed

Solem, Caitlyn T; Kwon, Youngmin; Shah, Ruchit M; Aly, Abdalla; Botteman, Marc F

2018-02-05

The Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) has been used to evaluate the clinical benefits and risks of oncology treatments. However, limited information is available to interpret and contextualize Q-TWiST results. Areas covered: A systematic review of Q-TWiST literature was conducted to provide contextualizing benchmarks for future studies. 51 articles with 81 unique Q-TWiST comparisons were identified. The mean (95% CI) and median absolute Q-TWiST gains for treatment versus control arms were 2.78 (1.82-3.73) months and 2.20 months across all cancers, respectively. The mean (median) relative Q-TWiST gains were 7.8% (7.2%) across all cancers. Most (88%) studies reported positive gains. The percentage of studies with relative Q-TWiST gains ≥10% (ie, clinically important difference) and ≥15% (ie, clearly clinically important difference) were 40.0% and 22.7%, respectively. Expert commentary: The relevance of Q-TWiST in assessing net clinical benefits of cancer therapy has not diminished, despite an arguably low number of published studies. The interest in such assessment is highlighted by the recent emergence of oncology value frameworks. The Q-TWiST should be compelling to clinicians as it integrates clinical information (ie, toxicity, relapse/progression, and survival) and patient preferences for each of these states into a single meaningful index.

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

75 FR 8365 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... respondents respondent (in hours) Diabetes Prevention and Control Programs Annual Report 53 1 51 Semi-Annual... Project Automated Management Information System (MIS) for Diabetes Prevention and Control Programs (OMB No... Description Diabetes is the seventh leading cause of death in the United States. To reduce the burden of this...

A comparison of male and female smokeless tobacco use.

PubMed

Cohen-Smith, D; Severson, H H

1999-09-01

This study explored the factors associated with female smokeless tobacco (ST) use and examined gender differences in factors related to use. Interviews were conducted either in person or by telephone with 51 female and 59 male users from the Pacific Northwest. The interview included both quantitative and qualitative items assessing personal, social, and substance use variables. Male and female users were found to be similar in a variety of areas, such as reasons for initiating use, use of ST in response to different mood states, and high rates of experimentation with other drugs. However, female users reported using ST for weight control more extensively, identified a greater influence by other female users, and reported fewer friends knowing about their use. Male users reported using ST more often during sports activities and in the workplace than did female users, and were almost three times more likely to be highly addicted to ST. The implications of the study for the development of prevention and cessation programs are discussed.

Future shift of the relative roles of precipitation and temperature in controlling annual runoff in the conterminous United States

Treesearch

Kai Duan; Ge Sun; Steven G. McNulty; Peter V. Caldwell; Erika C. Cohen; Shanlei Sun; Heather D. Aldridge; Decheng Zhou; Liangxia Zhang; Yang Zhang

2017-01-01

This study examines the relative roles of cli- matic variables in altering annual runoff in the contermi- nous United States (CONUS) in the 21st century, using a monthly ecohydrological model (the Water Supply Stress In- dex model, WaSSI) driven with historical records and future scenarios constructed from 20 Coupled Model Intercompar- ison Project Phase 5 (CMIP5)...

Impact of Nutrition on Health and Disease in Blacks and Other Minorities. Proceedings of the Meharry Medical College Annual Nutrition Workshop (1st, Nashville, Tennessee, October 28-30, 1987). Annual Nutrition Workshop Series, Volume 1.

ERIC Educational Resources Information Center

Enwonwu, Cyril O., Ed.

Participants in this workshop were scientists from various disciplines, including public health, oncology, nutrition, epidemiology, biochemistry, immunology, pharmacology, pediatrics, geriatric medicine, and the behavioral sciences. The workshop featured deliberations by medical experts on the dimensions and demographics of hunger in America. The…

Canadian Mathematics Education Study Group = Groupe Canadien d'etude en didactique des mathematiques. Proceedings of the Annual Meeting (23rd, St. Catherine's, ON, June 4-8, 1999).

ERIC Educational Resources Information Center

McLoughlin, John Grant, Ed.

This document contains the proceedings of 1999 annual meeting of the Canadian Mathematics Education Study Group (CMESG). Papers include: (1) "Mathematics Lecture I: The Impact of Technology on the Doing of Mathematics" (Jonathan Borwein); (2) "Mathematics Lecture II: The Decline and Rise of Geometry in 20th Century North America" (Walter…

VISION: Illuminating the Pathways to a Clean Energy Economy - JISEA 2016 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

2016-03-01

This report demonstrates JISEA's successes over the past year and previews our coming work. The 2016 Annual Report highlights JISEA accomplishments in low-carbon electricity system research, international collaboration, clean energy manufacturing analysis, 21st century innovation strategy, and more. As we look to the coming year, JISEA will continue to navigate complex issues, present unique perspectives, and envision a clean energy economy.

Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2016-01-01

This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

Magic year for multiple myeloma therapeutics: Key takeaways from the ASH 2015 annual meeting.

PubMed

Zhang, Kejie; Desai, Aakash; Zeng, Dongfeng; Gong, Tiejun; Lu, Peihua; Wang, Michael

2017-02-07

Despite the availability of various anticancer agents, Multiple Myeloma (MM) remains incurable in most cases, along with high relapse rate in the patients treated with these agents. The year 2015 saw major advancements in our battle against multiple myeloma. In 2015, the U.S. Food and Drug Administration (FDA) approved three new therapies for multiple myeloma, namely Ixazomib (an oral proteasome inhibitor), Daratumumab and Elotuzumab (monoclonal antibodies against CD38 and SLAMF7 respectively). The purpose of this review is to provide a detailed analysis of these aforementioned breakthrough therapies and two other newer agents, Filanesib (kinesis spindle inhibitor) and selinexor (SINE inhibitor), presented at the 2015 annual meeting of American Society of Hematology (ASH). We also describe the role of agents targeting PD-1 axis and chimeric antigen receptor T (CAR-T) cells in the treatment of MM.

LMOP Special Session

EPA Pesticide Factsheets

The Landfill Methane Outreach Program (LMOP) is collaborating with the Solid Waste Association of North America (SWANA) to organize a panel in conjunction with their upcoming 41st Annual Landfill Gas and Biogas Symposium in Denver, Colorado.

St. Lucia.

PubMed

1987-06-01

The population of St Lucia was 123,000 in 1986, with an annual growth rate of 2%. The infant mortality rate stands at 22.2/1000 live births, and life expectancy is 70.3 years for males and 74.9 years for females. The literacy rate is 78%. St Lucia's labor force is allocated as follows: agriculture, 36.6%; industry and commerce, 20.1%; and services, 18.1%. The gross national product (GNP) was US$146 million in 1985, with an annual growth rate of 3% and a per capita GNP of $1071. St Lucia is a parliamentary democracy modeled on the British Westminster system. The island is divided into 16 parishes and 1 urban area (the capital, Castries). St Lucia is currently a politically stable country, although the high level of youth unemployment is a cause for concern. Ongoing stability may depend on the government's ability to provide services such as jobs and housing. The economy has evolved from a monocrop sugar plantation type to a diversified economy based on agriculture, industry, and tourism. Agriculture, dominated by the banana industry, is characterized by the participation of a large number of small and medium-sized enterprises. Industry is being encouraged through the provision of incentives such as tax rebates. The government is attempting to maintain a sound investment climate through a tripartite dialogue with the private sector and trade unions. Overall economic policy is predicated on the attraction of sound investments, by both local and foreign entities, to accelerate the rate of economic growth, solve the unemployment problem, and generate a solid balance-of-payments position.

Spatio-Temporal Analysis of Trends and periodicities of regional drought projections in India

NASA Astrophysics Data System (ADS)

Gupta, Vivek; Jain, Manoj Kumar

2017-04-01

Climate change is believed to be altering the hydrologic cycle of different regions worldwide. This may alter the occurrence and distribution of extreme events such as droughts and floods. India is one of the most drought affected country, it is therefore important to understand spatiotemporal variation of droughts in future due to climate change. In this paper, we have analyzed the spatiotemporal projections of droughts over India for 21st century using Global Climate Model (GCM) precipitation projections of ESM2G model under two Representative Concentration Pathways (RCP) namely, RCP 4.5 and RCP 8.5. K-means Clustering algorithm has been exploited to obtain homogeneous precipitation region in India for regional drought analysis. Further, temporal analysis of projected annual minimum SPI for year 2006 to 2100 has been performed for different homogeneous regions obtained using cluster analysis. Trend analysis of annual minimum SPI series has also been performed using Mann-Kendall and Sen's slope method. Furthermore, periodicity in SPI series have been examined using wavelet periodogram analysis. Findings of this paper suggest that major drought events for Northeastern and Southern India are likely to occur in second half of the 21st century while for all other parts of India, most of the major drought events are expected in first half of the 21st century. Also, wavelet periodicity analysis indicates inter-annual periodicities of projected droughts between 3 to 9.5 years in different regions of India.

Estimation of historic flows and sediment loads to San Francisco Bay,1849–2011

USGS Publications Warehouse

Moftakhari, H.R.; Jay, D.A.; Talke, S.A.; Schoellhamer, David H.

2015-01-01

River flow and sediment transport in estuaries influence morphological development over decadal and century time scales, but hydrological and sedimentological records are typically too short to adequately characterize long-term trends. In this study, we recover archival records and apply a rating curve approach to develop the first instrumental estimates of daily delta inflow and sediment loads to San Francisco Bay (1849–1929). The total sediment load is constrained using sedimentation/erosion estimated from bathymetric survey data to produce continuous daily sediment transport estimates from 1849 to 1955, the time period prior to sediment load measurements. We estimate that ∼55% (45–75%) of the ∼1500 ± 400 million tons (Mt) of sediment delivered to the estuary between 1849 and 2011 was the result of anthropogenic alteration in the watershed that increased sediment supply. Also, the seasonal timing of sediment flux events has shifted because significant spring-melt floods have decreased, causing estimated springtime transport (April 1st to June 30th) to decrease from ∼25% to ∼15% of the annual total. By contrast, wintertime sediment loads (December 1st to March 31st) have increased from ∼70% to ∼80%. A ∼35% reduction of annual flow since the 19th century along with decreased sediment supply has resulted in a ∼50% reduction in annual sediment delivery. The methods developed in this study can be applied to other systems for which unanalyzed historic data exist.

38 CFR 51.210 - Administration.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.210 Administration. A facility must be... (annual at time of survey); (6) The number of nursing home patients who are veterans and non-veterans, the... Veterans. The percent of the facility residents eligible for VA nursing home care must be at least 75...

38 CFR 51.210 - Administration.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.210 Administration. A facility must be... (annual at time of survey); (6) The number of nursing home patients who are veterans and non-veterans, the... Veterans. The percent of the facility residents eligible for VA nursing home care must be at least 75...

38 CFR 51.210 - Administration.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.210 Administration. A facility must be... (annual at time of survey); (6) The number of nursing home patients who are veterans and non-veterans, the... residents eligible for VA nursing home care must be at least 75 percent veterans except that the veteran...

38 CFR 51.210 - Administration.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.210 Administration. A facility must be... (annual at time of survey); (6) The number of nursing home patients who are veterans and non-veterans, the... Veterans. The percent of the facility residents eligible for VA nursing home care must be at least 75...

38 CFR 51.210 - Administration.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.210 Administration. A facility must be... (annual at time of survey); (6) The number of nursing home patients who are veterans and non-veterans, the... Veterans. The percent of the facility residents eligible for VA nursing home care must be at least 75...

Our Stories: Innovation and Excellence in Rural Education. Proceedings of National Rural Education Conference of the Society for the Provision of Education in Rural Australia (21st, Darwin, Northern Territory, Australia, October 2005)

ERIC Educational Resources Information Center

Boylan, Colin, Ed.

2005-01-01

The papers contained in this document represent the keynote addresses, refereed and non-refereed conference papers from the 21st National Conference of the Society for the Provision of Education in Rural Australia (SPERA). The theme for this national annual conference was: Our Stories: Innovation and Excellence in Rural Education. Keynote…

Leadership Seminar 1989: Workforce 2000. Proceedings of the American Association of Community and Junior Colleges' and St. Petersburg Junior College's Annual Leadership Seminar (2nd, Grand Rapids, Michigan, October 26-27, 1989).

ERIC Educational Resources Information Center

Kuttler, Carl M., Jr.; And Others

In October 1989, St. Petersburg Junior College and the American Association of Community and Junior Colleges sponsored a seminar on strategies that community and junior colleges can use in working with business and industry to meet America's future work force needs. The proceedings of the seminar contains the text of presentations by nine…

NOTES FOR COMMUNITY COLLEGE TRUSTEES, I, II--REPORTS OF ANNUAL CONFERENCES CONDUCTED FOR COMMUNITY COLLEGE TRUSTEES AND PRESIDENTS BY THE MIDWEST COMMUNITY COLLEGE LEADERSHIP PROGRAM (1ST, 2D, 3D, ANN ARBOR, MICHIGAN).

ERIC Educational Resources Information Center

BANFIELD, RALPH W.; HALL, GEORGE L.

PAPERS PRESENTED AT THREE CONFERENCES FOR COMMUNITY COLLEGE TRUSTEES AND PRESIDENTS INCLUDED (1) A CONSIDERATION OF THE ROLES OF THE LIBERAL ARTS COLLEGE, THE UNIVERSITY, AND THE COMMUNITY COLLEGE, (2) FACULTY RELATIONS WITH ADMINISTRATION AND STAFF, (3) A CASE STUDY OF THE DEVELOPMENT OF THE ST. LOUIS JUNIOR COLLEGE DISTRICT, (4) FEDERAL…

Accomplishments under the Airport Improvement Program: Fiscal Year 1990 (Ninth Annual Report)

DTIC Science & Technology

1990-01-01

ST PAUL 06 $259,200 INSTALL TAXIWAY SIGNS; EXTEND SERVICE ST PAUL DOWNTOWN HOLMAN FIELD ROAD (RELIEVER) THIEF RIVER FALLS 01 $69,075 INSTALL RUNWAY AND...TAXIWAY SIGNS THIEF RIVER FALLS REGIONAL (COMMERCIAL SERVICE) MISSISSIPPI S2 $101,000 CONDUCT STATE SYSTEM PLAN STUDY STATE OF MISSISSIPPI (SYSTEM...SOL5tRG-HUNTERDON (GENERAL AVIATION) TETERBORO 09 $174,103 ACQUIRE SNOW REMOVAL EQUIPMENT TETERBORO (RELIEVER) TOMS RIVER Oa $189,764 IMPROVE DRAINAGE

Modeling the Magnetic and Thermal Structure of Active Regions: 1st Year 1st Semi-Annual Progress Report

NASA Technical Reports Server (NTRS)

Mikic, Zoran

2003-01-01

This report covers technical progress during the first six months of the first year of NASA SR&T contract "Modeling the Magnetic and Thermal Structure of Active Regions", NASW-03008, between NASA and Science Applications International Corporation, and covers the period January 14, 2003 to July 13, 2003. Under this contract SAIC has conducted research into theoretical modeling of the properties of active regions using the MHD model.

Implementation of a national external quality assessment program for medical laboratories in Burkina Faso: challenges, lessons learned, and perspectives.

PubMed

Sakandé, Jean; Nikièma, Abdoulaye; Kabré, Elie; Sawadogo, Charles; Nacoulma, Eric W; Sanou, Mamadou; Sangaré, Lassana; Traoré-Ouédraogo, Rasmata; Sawadogo, Mamadou; Gershy-Damet, Guy Michel

2014-02-01

The National External Quality Assessment (NEQA) program of Burkina Faso is a proficiency testing program mandatory for all laboratories in the country since 2006. The program runs two cycles per year and covers all areas of laboratories. All panels were validated by the expert committee before dispatch under optimal storage and transport conditions to participating laboratories along with report forms. Performance in the last 5 years varied by panel, with average annual performance of bacteriology panels for all laboratories rising from 75% in 2006 to 81% in 2010 and with a best average performance of 87% in 2007 and 2008. During the same period, malaria microscopy performance varied from 85% to 94%, with a best average performance of 94% in 2010; chemistry performance increased from 87% to 94%, with a best average annual performance of 97% in 2009. Hematology showed more variation in performance, ranging from 61% to 86%, with a best annual average performance of 90% in 2008. Average annual performance for immunology varied less between 2006 and 2010, recording 97%, 90%, and 95%. Except for malaria microscopy, annual performances for enrolled panels varied substantially from year to year, indicating some difficulty in maintaining consistency in quality. The main challenges of the NEQA program observed between 2006 to 2010 were funding, sourcing, and safe transportation of quality panels to all laboratories countrywide.

Low Energy Multi-Stage Atrial Defibrillation Therapy Terminates Atrial Fibrillation with Less Energy than a Single Shock

PubMed Central

Li, Wenwen; Janardhan, Ajit H.; Fedorov, Vadim V.; Sha, Qun; Schuessler, Richard B.; Efimov, Igor R.

2011-01-01

Background Implantable device therapy of atrial fibrillation (AF) is limited by pain from high-energy shocks. We developed a low-energy multi-stage defibrillation therapy and tested it in a canine model of AF. Methods and Results AF was induced by burst pacing during vagus nerve stimulation. Our novel defibrillation therapy consisted of three stages: ST1 (1-4 low energy biphasic shocks), ST2 (6-10 ultra-low energy monophasic shocks), and ST3 (anti-tachycardia pacing). Firstly, ST1 testing compared single or multiple monophasic (MP) and biphasic (BP) shocks. Secondly, several multi-stage therapies were tested: ST1 versus ST1+ST3 versus ST1+ST2+ST3. Thirdly, three shock vectors were compared: superior vena cava to distal coronary sinus (SVC>CSd), proximal coronary sinus to left atrial appendage (CSp>LAA) and right atrial appendage to left atrial appendage (RAA>LAA). The atrial defibrillation threshold (DFT) of 1BP shock was less than 1MP shock (0.55 ± 0.1 versus 1.38 ± 0.31 J; p =0.003). 2-3 BP shocks terminated AF with lower peak voltage than 1BP or 1MP shock and with lower atrial DFT than 4 BP shocks. Compared to ST1 therapy alone, ST1+ST3 lowered the atrial DFT moderately (0.51 ± 0.46 versus 0.95 ± 0.32 J; p = 0.036) while a three-stage therapy, ST1+ST2+ST3, dramatically lowered the atrial DFT (0.19 ± 0.12 J versus 0.95 ± 0.32 J for ST1 alone, p=0.0012). Finally, the three-stage therapy ST1+ST2+ST3 was equally effective for all studied vectors. Conclusions Three-stage electrotherapy significantly reduces the AF defibrillation threshold and opens the door to low energy atrial defibrillation at or below the pain threshold. PMID:21980076

Acquisition of Oceanographic Measurements from Baleen Whales and Acquisition of Oceanographic Measurements from Baleen Whales: Field Deployments of Tags Developed Under Grant ONR (N00014-13-1-0854)

DTIC Science & Technology

2015-09-30

Jonas Teilmann Department of Bioscience Aarhus University Fredriksborgvej 399 DK-4000 Roskilde Denmark phone: +45 21424291 fax: +45 87 16 87 51...Mammal Research Unit (SMRU, www.smru.st-andrews.ac.uk), University of St. Andrews, Scotland. WORK COMPLETED The project developed a prototype CTD...temperature and depth components from that work along with the tag controller/transmitter etc, are all still valid. • The risk for building a new tag fall

Summary Report - Strategic Weapons on the 21st Century Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, B.

2017-04-21

This 11th annual event focused on changes in the security environment and their implications for the U.S. approach to deterrence, with special attention to extended deterrence in Europe and East Asia.

AQUATOX Training Documents

EPA Pesticide Factsheets

A one-day short course on AQUATOX was presented as part of the Society of Environmental Toxicology and Chemistry (SETAC) North America 31st Annual Meeting, held November 7-11, 2010 in Portland, OR. These are the presentation slides.

Potentiometric surfaces and water-level trends in the Cockfield (upper Claiborne) aquifer in southern Arkansas and the Wilcox (lower Wilcox) aquifer of northeastern and southern Arkansas, 2012

USGS Publications Warehouse

Rodgers, Kirk D.

2015-01-01

Linear regression analysis of long-term hydrographs was used to determine the mean annual water-level rise and decline in the Wilcox aquifer in the northeastern and southern areas of Arkansas. In the northeastern area, the mean annual water level declined in all seven counties. The mean annual declines ranged from -0.55 ft/yr in Craighead County to -1.46 ft/yr in St. Francis County. In the southern area, the annual rise and decline calculations for wells with over 20 years of records indicate rising and declining water levels in Clark, Hot Spring, and Nevada Counties. The mean annual water level declined in all counties except Hot Spring County.

Temporal Causal Diagrams for Diagnosing Failures in Cyber Physical Systems

DTIC Science & Technology

2014-10-02

11 P Open Close C Close none St Close Table 3. Transition Information for Distance Relay’s behavioral model. Rows 1-7 deal with the anomaly detection ... PROGNOSTICS AND HEALTH MANAGEMENT SOCIETY 2014 238 ANNUAL CONFERENCE OF THE PROGNOSTICS AND HEALTH MANAGEMENT SOCIETY 2014 fall into the Zone settings of...OF THE PROGNOSTICS AND HEALTH MANAGEMENT SOCIETY 2014 239 ANNUAL CONFERENCE OF THE PROGNOSTICS AND HEALTH MANAGEMENT SOCIETY 2014 event systems has

BMC Blood Disorders becomes BMC Hematology: evolving along with the hematology field.

PubMed

Chap, Christna

2013-04-10

This Editorial marks the launch of BMC Hematology, formerly known as BMC Blood Disorders, within the BMC series of journals published by BioMed Central. The scope of BMC Hematology encompasses basic, experimental and clinical research related to hematology. In this Editorial we will discuss the rationale behind this relaunch and how, as an open access journal providing unrestricted and free access to scientific and scholarly work, BMC Hematology will help disseminate research in the hematology field in a freely-accessible manner.

Preliminary Evaluation of the Community Multiscale Air Quality (CMAQ) Model Version 5.1

EPA Science Inventory

The AMAD will perform two annual CMAQ model simulations, one with the current publically available version of the CMAQ model (v5.0.2) and the other with the beta version of the new model (v5.1). The results of each model simulation will then be compared to observations and the pe...

Clinical Epidemiology and Molecular Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Nepal: Characteristics of Sequence Types 131 and 648

PubMed Central

Sherchan, Jatan Bahadur; Miyoshi-Akiyama, Tohru; Ohmagari, Norio; Kirikae, Teruo; Nagamatsu, Maki; Tojo, Masayoshi; Ohara, Hiroshi; Sherchand, Jeevan B.; Tandukar, Sarmila

2015-01-01

Recently, CTX-M-type extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli strains have emerged worldwide. In particular, E. coli with O antigen type 25 (O25) and sequence type 131 (ST131), which is often associated with the CTX-M-15 ESBL, has been increasingly reported globally; however, epidemiology reports on ESBL-producing E. coli in Asia are limited. Patients with clinical isolates of ESBL-producing E. coli in the Tribhuvan University teaching hospital in Kathmandu, Nepal, were included in this study. Whole-genome sequencing of the isolates was conducted to analyze multilocus sequence types, phylotypes, virulence genotypes, O25b-ST131 clones, and distribution of acquired drug resistance genes. During the study period, 105 patients with ESBL-producing E. coli isolation were identified, and the majority (90%) of these isolates were CTX-M-15 positive. The most dominant ST was ST131 (n = 54; 51.4%), followed by ST648 (n = 15; 14.3%). All ST131 isolates were identified as O25b-ST131 clones, subclone H30-Rx. Three ST groups (ST131, ST648, and non-ST131/648) were compared in further analyses. ST648 isolates had a proportionally higher resistance to non-β-lactam antibiotics and featured drug-resistant genes more frequently than ST131 or non-ST131/648 isolates. ST131 possessed the most virulence genes, followed by ST648. The clinical characteristics were similar among groups. More than 38% of ESBL-producing E. coli isolates were from the outpatient clinic, and pregnant patients comprised 24% of ESBL-producing E. coli cases. We revealed that the high resistance of ESBL-producing E. coli to multiple classes of antibiotics in Nepal is driven mainly by CTX-M-producing ST131 and ST648. Their immense prevalence in the communities is a matter of great concern. PMID:25824221

Workshop proceedings: challenges and opportunities in evaluating protein allergenicity across biotechnology industries.

PubMed

Stagg, Nicola J; Ghantous, Hanan N; Ladics, Gregory S; House, Robert V; Gendel, Steven M; Hastings, Kenneth L

2013-01-01

A workshop entitled "Challenges and Opportunities in Evaluating Protein Allergenicity across Biotechnology Industries" was held at the 51st Annual Meeting of the Society of Toxicology (SOT) in San Francisco, California. The workshop was sponsored by the Biotechnology Specialty Section of SOT and was designed to present the science-based approaches used in biotechnology industries to evaluate and regulate protein allergenicity. A panel of experts from industry and government highlighted the allergenicity testing requirements and research in the agricultural, pharmaceutical/biopharma, and vaccine biotechnology industries and addressed challenges and opportunities for advancing the science of protein allergenicity. The main learning from the workshop was that immunoglobulin E-mediated allergenicity of biotechnology-derived products is difficult to assess without human data. The approaches currently being used to evaluate potential for allergenicity across biotechnology industries are very different and range from bioinformatics, in vitro serology, in vivo animal testing, in vitro and in vivo functional assays, and "biosimilar" assessments (ie, biotherapeutic equivalents to innovator products). The challenge remains with regard to the different or lack of regulatory requirements for allergenicity testing across industries, but the novel approaches being used with bioinformatics and biosimilars may lead to opportunities in the future to collaborate across biotechnology industries.

Thermal conditions of rock slopes below unstable infrastructure in Alpine permafrost area: the cases of the Cosmiques hut and the Grands Montets cable-car station (Mont Blanc massif)

NASA Astrophysics Data System (ADS)

Duvillard, Pierre-Allain; Magnin, Florence; Mörtl, Christian; Ravanel, Ludovic; Deline, Philip

2017-04-01

Thermal state of steep permafrost-affected rock faces is crucial to assess the safety and reliability of mountain infrastructure as current permafrost degradation affects the rock slope stability. In the Mont-Blanc massif, 23 infrastructures are built on such a rock face with 13 of them that are characterized by a high risk of destabilization (Duvillard et al., 2015), including the upper station of the Grands Montets cable car (3325 m a.s.l.) as well as the Cosmiques hut (3613 m a.s.l.) on which we will focus. These two buildings have already been affected by different geomorphological processes. A rockfall event (600 m3) occurred for example on the SE face on the Arête inférieure des Cosmiques on the 21st of August 1998 (Ravanel et al., 2013) and the Grands Montets case shows a slow subsidence of the stairway over the last decade. In order to better assess the role of the permafrost in these processes and to gain insight on possible future geomorphic activity, we characterized the current permafrost conditions and simulated its changes up to the end of the 21st century using two complementary approaches: (i) the result of ERT (Electrical Resistivity Tomography) surveys carried out in October 2016 on the northern and southern faces right below the Cosmiques hut (at the level of the foundations) and at the Aiguilles des Grands Montets; (ii) the modeling of mean annual rock surface temperature for 2016 and at the end of the 21st century (Magnin et al., in rev.). Duvillard P.-A., Ravanel L., Deline P. (2015). Risk assessment of infrastructure destabilisation due to global warming in the high French Alps. Journal of Alpine Research, 103 (2). Magnin F., Josnin J.-Y., Ravanel L., Pergaud J., Pohl B., Deline P. (in rev.). Modelling rock wall permafrost degradation in the Mont Blanc massif from the LIA to the end of the 21st century. The Cryosphere Discuss., doi:10.5194/tc-2016-132. Ravanel L., Deline P., Lambiel C. and Vincent C. (2013). Instability of a high alpine rock ridge: the lower arête des Cosmiques, Mont-Blanc massif, France. Geografiska Annaler A, 95 : 51-66.

A phase II study of combination chemotherapy with docetaxel and carboplatin for patients with advanced or metastatic non-small cell lung cancer.

PubMed

Kasahara, Kazuo; Kimura, Hideharu; Shibata, Kazuhiko; Araya, Tomoyuki; Sone, Takashi; Oribe, Yoshitaka; Furusho, Shiho; Kita, Toshiyuki; Shirasaki, Hiroki; Oribe, Yoshitaka; Yoshimi, Yuzo; Ueda, Akihito; Tachibana, Hideki; Shintani, Hiromoto; Mizuguchi, Masayuki; Nishi, Kohichi; Fujimura, Masaki; Nakao, Shinji

2006-01-01

The aim of this phase II study was to evaluate the efficacy of combination chemotherapy consisting of docetaxel and carboplatin in patients with inoperable non-small cell lung cancer (NSCLC). For this multicenter phase II study, the eligibility criteria included histologically or cytologically proven inoperable NSCLC, measurable lesions, Eastern Cooperative Oncology Group performance status (PS) 0-2, adequate organ and bone marrow functions, and written informed consent. Patients received 60 mg/m2 of docetaxel and carboplatin (target AUC 5.5) on day 1 every 3 weeks until disease progression. The primary end-point of this study was response rate and the secondary end-points were toxicities, time to progression and overall survival. A total of 40 patients were enrolled and 39 patients were eligible. A complete response and partial response were observed in 1 and 13 patients, respectively. An objective response rate was 35.9% (95% confidential interval [CI] 20.8-51.0%). The median time to progression was 5.2 months and the median overall survival was 12.0 months. The 1- and 2-year survival rates were 53.8% and 25.1%, respectively. The major toxicities were leukocytopenia and neutropenia. Grade 3 or 4 thrombocytopenia was rare and non-hematological toxicities were generally mild. Grade 3 non-hematological toxicities were observed in 6 patients (2 with nausea and vomiting, 1 with diarrhea, 1 with elevated transaminase levels, 1 with allergic reaction and 1 with edema). No grade 4 non-hematological toxicities were observed. Docetaxel and carboplatin combination chemotherapy was well tolerated and active in Japanese patients with advanced or metastatic NSCLC.

Laparoscopic splenectomy in pediatric age: long-term follow-up.

PubMed

Ates, Ufuk; Tastekin, Nil Y; Gollu, Gulnur; Ergun, Ergun; Yagmurlu, Aydin

2017-12-01

In the last century, with the advancement of the diagnostic procedures, hematologic disorders in pediatric age group have been increased dramatically. In parallel with this increase, splenectomy procedures have also been popularized with different techniques and surgical outcomes. Laparoscopic splenectomy (LS) in the pediatric age group is generally accepted as a technically demanding procedure, which needs experience. The purpose of this study is to present the long-term follow-up results of a case series of children who underwent LS for a variety of hematologic disorders, evaluate possible complications and outcomes. All patients who were admitted to the clinic and who were scheduled for LS from 2005 to 2016 were considered for this study. The study parameters were grouped in four categories including socio-demographic data, preoperative evaluation, clinical follow-up and complications. There were 24 male (48.9%) and 25 (51.1%) female patients. The median age and body weight for the study group was 12 years and 35 kg. Most common indications for LS were thalassemia (13; 26.5%) and hereditary spherocytosis (12; 24.4%). As a technical standpoint, 2 patients (4%) underwent singleport LS surgery. The mean time for LS surgeries was found as 80 minutes. The total intraoperative complication rate was 4% (2/57). The mean time for hospital stay was 5 days. Mean follow-up period was 6.4 years (range: 6 months-16 years). There was no long-term complication. Bilirubin levels and need for blood transfusion significantly decreased in the long term follow-up period (p <0.05). LS is a powerful tool in the hands of an experienced surgeon. It's a safe and effective procedure in children with hematologic disorders resulting in shorter length of stay and lower complication rates. Sociedad Argentina de Pediatría

Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies.

PubMed

Mirouse, Adrien; Resche-Rigon, Matthieu; Lemiale, Virginie; Mokart, Djamel; Kouatchet, Achille; Mayaux, Julien; Vincent, François; Nyunga, Martine; Bruneel, Fabrice; Rabbat, Antoine; Lebert, Christine; Perez, Pierre; Renault, Anne; Meert, Anne-Pascale; Benoit, Dominique; Hamidfar, Rebecca; Jourdain, Mercé; Darmon, Michaël; Azoulay, Elie; Pène, Frédéric

2017-12-01

Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe sepsis and septic shock in patients with hematological malignancies. We performed a retrospective analysis of a prospectively collected database of patients with hematological malignancies who required intensive care unit (ICU) admission in 2010-2011. Patients with a main admission diagnosis of severe sepsis or septic shock were included in the present study. We assessed RBC transfusion during the first two days as part of initial resuscitation. Among the 1011 patients of the primary cohort, 631 (62.4%) were admitted to the ICU for severe sepsis (55%) or septic shock (45%). Among them, 210 (33.3%) patients received a median of 2 [interquartile 1-3] packed red cells during the first 48 h. Hemoglobin levels were lower in transfused patients at days 1 and 2 and became similar to those of non-transfused patients at day 3. Early RBC transfusion was more likely in patients with myeloid neoplasms and neutropenia. Transfused patients displayed more severe presentations as assessed by higher admission SOFA scores and blood lactate levels and the further requirements for organ failure supports. RBC transfusion within the first two days was associated with higher day 7 (20.5 vs. 13.3%, p = 0.02), in-ICU (39 vs. 25.2%, p < 0.001) and in-hospital (51 vs. 36.6%, p < 0.001) mortality rates. RBC transfusion remained independently associated with increased in-hospital mortality in multivariate logistic regression (OR 1.52 [1.03-2.26], p = 0.03) and propensity score-adjusted (OR 1.64 [1.05-2.57], p = 0.03) analysis. RBC transfusion is commonly used in the early resuscitation of septic patients with hematological malignancies. Although it was preferentially provided to the most severe patients, we found it possibly associated with an increased risk of death.

Hematologic and plasma chemistry RIs for cultured Striped catfish (Pangasius hypophthalmus) in recirculating aquaculture systems.

PubMed

Galagarza, Oscar A; Kuhn, David D; Smith, Stephen A; Hrubec, Terry C

2017-09-01

Striped catfish (Pangasius hypophthalmus) is a valuable aquaculture fish species produced primarily in Southeast Asia. In the United States, it is bred as an ornamental species. Striped catfish has high productivity and great demand in numerous countries around the world, yet little is known about its normal physiology. The objective of this study was to establish hematologic and blood chemistry RIs for healthy juvenile Striped catfish. Blood samples were collected from 70 Striped catfish raised in recirculating aquaculture systems. Whole blood and plasma samples were analyzed for multiple hematologic and chemistry variables using standard techniques. The RIs for hematology were as follows: PCV 23.5-35.9%, MCV 106.3-156.6 fL, RBC count 1.79-2.75 × 10 6 cells/μL, thrombocytes 26,318-73,333 cells/μL, total WBC count 36,294-94,286 cells/μL, total lymphocytes 18,997-59,998 cells/μL, small lymphocytes 13,763-51,490 cells/μL, large lymphocytes 715-21,200 cells/μL, granulocytes 4504-18,291 cells/μL, and monocytes 0-7549 cells/μL. Plasma chemistry RIs were the following: ALP 32.7-74.6 U/L, AST 20.3-1235.8 U/L, sodium 135.2-147.7 mmol/L, potassium 3.3-5.0 mmol/L, chloride 120.1-133.6 mmol/L, calcium 2.7-3.6 mmol/L, magnesium 0.9-1.3 mmol/L, phosphorous 1.4-2.7 mmol/L, glucose 4.6-7.6 mmol/L, cholesterol 2.8-5.3 mmol/L, total protein 30-42 g/L, albumin 7-11 g/L, globulin 22-32 g/L, albumin:globulin ratio 0.27-0.37, creatinine 0-8 μmol/L, and osmolality 251.8-327.9 mOsm/kg. Reference intervals reported here can help veterinarians and fish health specialists monitor the health status of Striped catfish under recirculating aquaculture conditions for research, exhibition, and production purposes. © 2017 American Society for Veterinary Clinical Pathology.

Pulpwood Production in the Lake States

Treesearch

James E. Blyth; Jerold T. Hahn

1977-01-01

This 31st annual report shows 1976 pulpwood production by county and species group in Michigan, Minnesota, and Wisconsin. Production in these three Lake States climbed to 4.7 million cords from 4.1 million cords in 1975

The new I-64 economic and regional mobility study.

DOT National Transportation Integrated Search

2011-11-01

The Final Report summarizes the 2008 and 2009 Annual Reports of all studys activities conducted during the I-64 Full-closure construction project in the St. Louis, Missouri region. These activities included project communications, public opinions,...

Arizona motor vehicle crash facts, 2004

DOT National Transportation Integrated Search

2005-01-01

This publication is an annual statistical review of the motor vehicle crashes in the State of Arizona for calendar year 2004. The : results are compiled from Arizona Traffic Accident Reports submitted to the Arizona Department of Transportation by st...

Second annual Transportation Infrastructure Engineering Conference.

DOT National Transportation Integrated Search

2013-10-01

The conference will highlight a few of the current projects that have been sponsored by the Center for Transportation : Infrastructure and Safety (CTIS), a national University Transportation Center at S&T. In operation since 1998, the CTIS supports :...

Epidemiology of AL amyloidosis: a real-world study using US claims data.

PubMed

Quock, Tiffany P; Yan, Tingjian; Chang, Eunice; Guthrie, Spencer; Broder, Michael S

2018-05-22

Amyloid light-chain (AL) amyloidosis is a rare disease caused by extracellular deposition of misfolded immunoglobulin light chains. This study aimed to provide an up-to-date estimate of prevalence and incidence of AL amyloidosis in the United States. Using claims databases from years 2007 to 2015, adults ≥18 years old with AL amyloidosis were included if they had (1) at least 1 inpatient or 2 outpatient claims consistent with AL amyloidosis and (2) received 1 AL-specific treatment. Prevalence was calculated as the number of AL patients divided by the number of enrollees on June 30th of each calendar year. Incidence was calculated as the number of patients with AL who were disease-free and enrolled with a health plan for 1 year prior, divided by the number of enrollees with enrollment from July 1st of the previous year to June 30th of each calendar year. The prevalence of AL amyloidosis increased significantly between 2007 and 2015, from 15.5 cases per million in 2007 to 40.5 in 2015, an annual percentage change (APC) of 12% ( P < .001). The incidence ranged from 9.7 to 14.0 cases per million person-years (APC, 3%; P = .114) with no statistically significant increase. There was an increase in AL amyloidosis prevalence over a 9-year period coupled with stable incidence rates. Although there is no diagnosis code specific to AL amyloidosis and no validated method for identifying this condition using claims data, extrapolating from our data, there are at least 12 000 adults in the United States living with AL amyloidosis, and the number seems likely to rise. © 2018 by The American Society of Hematology.

BMC Blood Disorders becomes BMC Hematology: evolving along with the hematology field

PubMed Central

2013-01-01

This Editorial marks the launch of BMC Hematology, formerly known as BMC Blood Disorders, within the BMC series of journals published by BioMed Central. The scope of BMC Hematology encompasses basic, experimental and clinical research related to hematology. In this Editorial we will discuss the rationale behind this relaunch and how, as an open access journal providing unrestricted and free access to scientific and scholarly work, BMC Hematology will help disseminate research in the hematology field in a freely-accessible manner. PMID:24499661

Exercise-induced ST-segment elevation during treadmill exercise testing.

PubMed

Patanè, Salvatore; Marte, Filippo

2010-09-03

The exercise electrocardiogram is a commonly used non-invasive and inexpensive method for detection of electrocardiogram (ECG) changes secondary to myocardial ischemia. It has been reported that in patients with a first myocardial infarction and without residual ischemia, exercise-induced ST-segment elevation in Q leads is related to a more damaged coronary microcirculation and to less viable myocardium. Exercise-induced ST-segment elevation is a rare phenomenon in patients without prior myocardial infarction. When occurring purely during exercise, coronary lesions are frequent and often severe, and on the other hand ST-segment elevation of the recovery phase is frequently associated with normal arteries or less severe lesions. We present a case of exercise-induced ST-segment elevation in a 51-year-old Italian man. Coronary angiography revealed a significant left anterior descending coronary artery stenosis, a significant circumflex coronary artery stenosis, a significant first obtuse marginal coronary artery stenosis and a significant second obtuse marginal coronary artery stenosis. Percutaneous transluminal coronary angioplasty with implantation of stents was successfully performed. Also this case is illustrative of the rare phenomenon of exercise-induced ST-segment elevation. Copyright © 2008 Elsevier B.V. All rights reserved.

76 FR 18649 - Technical Revisions to Actuarial Information on Form 5500 Annual Return/Report for Pension Plans...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... DEPARTMENT OF LABOR Employee Benefits Security Administration 29 CFR Part 2520 Technical Revisions... Alternatives Under Pension Relief Act of 2010 AGENCY: Employee Benefits Security Administration, Labor. ACTION... 5500 Annual Return/Report of Employee Benefit Plan have been adopted in IRS Notice 2010-83 (2010-51 I.R...

Revised Uniform Summary of Surface Weather Observations (RUSSWO), March AFB, Riverside, California.

DTIC Science & Technology

1978-11-28

0i 25 1.. -. V 4 j44 . 51.52 7429 ;d. F NIO .w 11 21 ;U S 56.%4 7 00 r Ai <u’-,l i .- . i i ~~4 5,’ ,-<.l i ,.51 t<. ,O~ S iRM i rvzzi j i : - Sepi...usLF SURFACE WINDS H E~-ER StVC~uCPERCENTAGE FREQUENCY OF WINE ) DIRECTION AND SPEED (FROM HOURLY OBSERIVATIONS) 231174 mr’FC AF5 rA/IV~EFR5Ie ~-O73

1. COMPARISON OF PLANS, SHOWING KONGENSGADE 6 (see photograph VI50 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. COMPARISON OF PLANS, SHOWING KONGENSGADE 6 (see photograph VI-50 50-2 for elevation), KONGENSGADE 8 (see photograph VI-50-3 for elevation), KONGENSGADE 9 (see photograph VI-50-3 for elevation), KONGENSGADE 17 (see photograph VI-50-5 for elevation), KONGENSGADE 56 (see photograph VI-50-8 for elevation), & KONGENSGADE 57 (see photograph VI-50-9 for elevation) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

Subtype Distribution of Blastocystis Isolates in Sebha, Libya

PubMed Central

Abdulsalam, Awatif M.; Ithoi, Init; Al-Mekhlafi, Hesham M.; Al-Mekhlafi, Abdulsalam M.; Ahmed, Abdulhamid; Surin, Johari

2013-01-01

Background Blastocystis is a genetically diverse and a common intestinal parasite of humans with a controversial pathogenic potential. This study was carried out to identify the Blastocystis subtypes and their association with demographic and socioeconomic factors among outpatients living in Sebha city, Libya. Methods/Findings Blastocystis in stool samples were cultured followed by isolation, PCR amplification of a partial SSU rDNA gene, cloning, and sequencing. The DNA sequences of isolated clones showed 98.3% to 100% identity with the reference Blastocystis isolates from the Genbank. Multiple sequence alignment showed polymorphism from one to seven base substitution and/or insertion/deletion in several groups of non-identical nucleotides clones. Phylogenetic analysis revealed three assemblage subtypes (ST) with ST1 as the most prevalent (51.1%) followed by ST2 (24.4%), ST3 (17.8%) and mixed infections of two concurrent subtypes (6.7%). Blastocystis ST1 infection was significantly associated with female (P = 0.009) and low educational level (P = 0.034). ST2 was also significantly associated with low educational level (P= 0.008) and ST3 with diarrhoea (P = 0.008). Conclusion Phylogenetic analysis of Libyan Blastocystis isolates identified three different subtypes; with ST1 being the predominant subtype and its infection was significantly associated with female gender and low educational level. More extensive studies are needed in order to relate each Blastocystis subtype with clinical symptoms and potential transmission sources in this community. PMID:24376805

Subtype distribution of Blastocystis isolates in Sebha, Libya.

PubMed

Abdulsalam, Awatif M; Ithoi, Init; Al-Mekhlafi, Hesham M; Al-Mekhlafi, Abdulsalam M; Ahmed, Abdulhamid; Surin, Johari

2013-01-01

Blastocystis is a genetically diverse and a common intestinal parasite of humans with a controversial pathogenic potential. This study was carried out to identify the Blastocystis subtypes and their association with demographic and socioeconomic factors among outpatients living in Sebha city, Libya. Blastocystis in stool samples were cultured followed by isolation, PCR amplification of a partial SSU rDNA gene, cloning, and sequencing. The DNA sequences of isolated clones showed 98.3% to 100% identity with the reference Blastocystis isolates from the Genbank. Multiple sequence alignment showed polymorphism from one to seven base substitution and/or insertion/deletion in several groups of non-identical nucleotides clones. Phylogenetic analysis revealed three assemblage subtypes (ST) with ST1 as the most prevalent (51.1%) followed by ST2 (24.4%), ST3 (17.8%) and mixed infections of two concurrent subtypes (6.7%). ST1 infection was significantly associated with female (P = 0.009) and low educational level (P = 0.034). ST2 was also significantly associated with low educational level (P= 0.008) and ST3 with diarrhoea (P = 0.008). Phylogenetic analysis of Libyan Blastocystis isolates identified three different subtypes; with ST1 being the predominant subtype and its infection was significantly associated with female gender and low educational level. More extensive studies are needed in order to relate each Blastocystis subtype with clinical symptoms and potential transmission sources in this community.

Determinants of hematology-oncology trainees' postfellowship career pathways with a focus on nonmalignant hematology

PubMed Central

Jenkins, Sarah; Mikhael, Joseph; Gitlin, Scott D.

2018-01-01

Nonmalignant hematologic conditions are extremely prevalent and contribute significantly to the global burden of disease. The US health care system may soon face a shortage of specialists in nonmalignant hematology. We sought to identify factors that lead hematology-oncology fellows to pursue (or not to pursue) careers in nonmalignant hematology. Cross-sectional, web-based survey distributed to 149 graduates of a hematology-oncology fellowship program at a large academic medical center between 1998 and 2016. Eighty-six out of 149 graduates responded (57.7%); most (59 [68.6%]) practice at an academic medical center. Respondents spend a mean of 61% of their time in clinical practice, 23.7% conducting research, 5.2% in education, and 5.2% in administration. Those in clinical practice spend a mean of 52.1% of their time in solid tumor oncology, 37.5% in hematologic malignancies, and 10% in nonmalignant hematology; only 1 spent >50% of time practicing nonmalignant hematology. Factors most significantly affecting choice of patient population included clinical experience during fellowship and intellectual stimulation of the patient population/disease type. Factors that could have most significantly influenced a decision to spend more time in nonmalignant hematology included increased exposure/access to role models and mentors and opportunities for better career growth/advancement. Fellowship graduates spend >50% of their time in clinical practice, but almost none spend a significant amount of time practicing nonmalignant hematology. Given the growing number of patients with nonmalignant hematologic conditions and a possible future provider shortage, medical trainees should be encouraged to pursue careers in nonmalignant hematology. PMID:29463548

Determination of base-flow characteristics at selected streamflow-gaging stations on the Mad River, Ohio

USGS Publications Warehouse

Koltun, G.F.

1995-01-01

This report describes the results of a study to estimate characteristics of base flow and sustained ground-water discharge at five streamflow-gaging stations on the Mad River in Ohio. The five streamflow-gaging stations are located at Zanesfield, near Urbana, at St. Paris Pike (at Eagle City), near Springfield, and near Dayton. The median of the annual-mean base flows, determined by means of hydrograph separation, ranged from 0.64 (ft3/s)/mi2 (cubic feet per second per square mile) at Zanesfield to 0.74 (ft3/s)/mi2 at St. Paris Pike. The median percentage of annual total streamflow attributed to base flow ranged from 61.8 percent at Zanesfield to 76.1 percent near Urbana. Estimates of an upper limit (or threshold) at which base flows can be considered to be composed predominately of sustained ground-water discharge were made by constructing and analyzing base- flow-duration curves. The sustained ground-water discharges (base flows less than or equal to the estimated sustained ground-water-discharge thresholds) are assumed to originate from ground-water- flow systems that are minimally affected by seasonal climatic changes. The median sustained ground- water discharge ranged from 0.11 (ft3/s)/mi2 at Zanesfield to 0.26 (ft3/s)/mi2 at St. Paris Pike (at Eagle City) and near Springfield. The median sustained ground-water discharge, expressed as a percentage of the median annual-mean base flow, ranged from 17.2 percent at Zanesfield to 38.6 percent near Springfield.

21 CFR 864.8625 - Hematology quality control mixture.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Hematology quality control mixture. 864.8625 Section 864.8625 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Reagents § 864.8625 Hematology...

21 CFR 864.8625 - Hematology quality control mixture.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Hematology quality control mixture. 864.8625 Section 864.8625 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Reagents § 864.8625 Hematology...

21 CFR 864.8625 - Hematology quality control mixture.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Hematology quality control mixture. 864.8625 Section 864.8625 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Reagents § 864.8625 Hematology...

NCI's Clinical Proteomic Tumor Analysis Consortium 1st Annual Scientific Symposium | Office of Cancer Clinical Proteomics Research

Cancer.gov

On behalf of the National Cancer Institute and the Office of Cancer Clinical Proteomics Research, you are invited to the First Annual CPTAC Scientific Symposium on Wednesday, November 13, 2013. The purpose of this symposium, which consists of plenary and poster sessions, is for investigators from CPTAC community and beyond to share and discuss novel biological discoveries, analytical methods, and translational approaches using CPTAC data.

International Perspectives on Environmental Education: Issues and Actions. Proceedings of the 1st International and 13th Annual Conference of the North American Association for Environmental Education (Banff, Alberta, Canada, October 5-9, 1984).

ERIC Educational Resources Information Center

Cox, Dorothy A., Ed.; Stapp, William B., Ed.

The proceedings of the first International Conference of the North American Association for Environmental Education (NAEE), which was also the 13th annual conference of the National Association of Environmental Education as the NAEE was formerly known, provides as complete a record as possible of the conference activities. Papers and reports are…

Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas.

PubMed

Saez, J L; Sanz, C; Durán, M; García, P; Fernandez, F; Minguez, O; Carbajo, L; Mardones, F; Perez, A; Gonzalez, S; Dominguez, L; Alvarez, J

2014-06-21

RB51 vaccination can minimise the diagnostic problems associated with S19 vaccination of adult cattle, but its use for bovine brucellosis (BB) control remains controversial. Here, the evolution of BB prevalence in five high prevalence areas in Spain subjected to different control measures is described: herd depopulation of infected herds (I-III) or mass vaccination with RB51 and S19-RB51 vaccination of replacement heifers (IV-V). Annual data from the eradication campaigns were analysed at the special incidence area (SIA) level and the time to obtain herd prevalence levels of <1 per cent ('controlled status') was obtained at the local veterinary unit (LVU) level and compared using Cox's proportional hazard model. A higher annual rate of decrease in herd prevalence was observed in the SIAs subjected to vaccination (46.9%, 95% CI 43.5% to 50.0%) compared with those managed using stamping out (14.9%, 95% CI 9.6% to 19.9%). No significant differences in the time to achieve controlled status were observed between the stamping-out and vaccination strategies used at the LVU level, with median times of 60 (stamping-out LVUs) and 63 (vaccination LVUs) months. These results suggest that RB51 mass vaccination, in combination with the S19-RB51 vaccination of replacement heifers and strict implementation of other eradication measures, may provide results at least comparable with those resulting from a herd depopulation based strategy. British Veterinary Association.

From yellow perch to round goby: A review of double-crested cormorant diet and fish consumption at three St. Lawrence River colonies, 1999–2013

USGS Publications Warehouse

Johnson, James H.; Farquhar, James F.; Klindt, Rodger M; Mazzocchi, Irene; Mathers, Alastair

2015-01-01

The number of double-crested cormorants (Phalacrocorax auritus) in the upper St. Lawrence River has increased markedly since the early 1990s. In 1999, a binational study was initiated to examine the annual diet composition and fish consumption of cormorants at colonies in the upper river. Since 1999, 14,032 cormorant pellets, collected from May through September each year, have been examined from St. Lawrence River colonies to estimate fish consumption and determine temporal and spatial variation in diet. Seasonal variation in diet composition within a colony was low. Prior to 2006 yellow perch was the primary fish consumed by cormorants in the upper St. Lawrence River. Round goby were first observed in cormorant diets in 2003 and by 2006 were the main fish consumed at two of the three colonies. The time interval it took from the first appearance of round goby in the diet at a colony to when goby were the dominant prey species varied by island, ranging from two to five years. Daily fish consumption at each cormorant colony increased significantly from the pre-round goby to post-round goby period. The mean annual biomass of yellow perch consumed decreased significantly during the post-round goby period at the three colonies. Reduced consumption of yellow perch by cormorants may alleviate suspected localized impacts on perch near some of the larger river colonies.

Annual report of the National Advisory Committee for Aeronautics (41st). administrative report including Technical Report nos. 1210 to 1253

NASA Technical Reports Server (NTRS)

1957-01-01

Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

AACR 2010: Strategy for Mapping of 20 Cancers - TCGA

Cancer.gov

TCGA held an NCI-sponsored session at the American Association for Cancer Research's (AACR) 101st Annual Meeting 2010 to address the program’s Phase II structure and strategies for sample acquisition, evolving technologies, data management and analysis.

75 FR 81624 - Advisory Committee on Interdisciplinary, Community-Based Linkages; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

..., Professional Development and Lifelong Learning for the 21st Century Health Care Workforce. The meeting will... the development of recommendations to be addressed in the 11th Annual ACICBL Report. Agenda items are...

Reconstructing Holocene seasonal hydrographic variability in the eastern North Atlantic using bivalve shells from St Kilda, Scotland

NASA Astrophysics Data System (ADS)

Alexandroff, Stella; Scourse, James; Butler, Paul; Schöne, Bernd; Reimer, Paula

2017-04-01

Bivalve shells like Arctica islandica and Glycymeris glycymeris can be used as highly resolved archives of past marine climate and long-term biomonitors. The annual growth patterns of the shell reflect the environment the animals live in and by cross-matching these growth patterns it is possible to construct multi-centennial, annually resolved chronologies that form a temporal template for isotope sampling. The aim of this study is to detect a signal of Atlantic hydrographic variability in Scottish Shelf Seas that is as far as possible uncontaminated by other influences. In May 2014, we collected dead valves and young live specimens of G. glycymeris from St Kilda, Outer Hebrides, Scotland, and in April 2016, live specimens of A. islandica were collected at the same location. This area is of particular interest as it is close to the Scottish shelf margin, has negligible freshwater input, and is thought to represent open-ocean North Atlantic signals well. We here present two floating chronologies, each spanning >180 years, built from dead-collected G. glycymeris shells from St Kilda. All the shells in these chronologies were assigned radiocarbon ages between 3700-3300 cal yr BP. By combining the radiocarbon dates and the chronological data derived from cross-matching annual bands in the shells, one of the floating chronologies could be further constrained to 3750-3500 cal yr BP (95% range). Sub-annual δ18O data from the floating chronologies and from the modern specimens show a strong seasonal signal and multi-year trends. We calibrate the δ18O results from the modern specimens with instrumental data, which enables us (subject to the assumption that there has been no change in δ18Owater) to compare mean and seasonal seawater temperatures between the present day and the fourth millennium BP.

Attitudes of medical laboratory technology graduates towards the internship training period at king faisal university.

PubMed

Bashawri, Layla A M; Ahmed, Mirghani A; Bahnassy, Ahmed A L; Al-Salim, Jawaher A

2006-05-01

The objective of this present survey was to look into the attitudes of medical laboratory technology (MLT) graduates towards the internship training period of the MLT Department, College of Applied Medical Sciences, King Faisal University. A self-administered questionnaire was designed and distributed for this purpose. The study period was from December 1(st) 2002 - 31(st) December 2004. Two-hundred questionnaires were distributed to recent graduates, and 115 were returned completed. All respondents agreed with the importance and necessity of the internship period, and felt it should not be reduced or eliminated. The most favorite laboratory where they liked to work was microbiology (70%). They all agreed that evaluation report with hospital staff and laboratory set up were vital in achieving the goals of the internship period. The majority stressed the significance of safety precautions and the application of theoretical knowledge before performing technical assignments. The respondents had very positive attitudes towards the internship-training period stressing its importance. The most favorite laboratory rotations were in rank order: Microbiology, Serology followed by Histotechnology, Hematology, Blood Banking and finally Clinical Chemistry. The majority of graduates had a very positive attitude also towards medical laboratory technology as a profession.

National Hematopoietic Stem Cells Transplant Registry in Poland: Nationwide Internet Reporting System and Results.

PubMed

Łęczycka, A; Dudkiewicz, M; Czerwiński, J; Malanowski, P; Żalikowska-Hołoweńko, J; Danielewicz, R

2016-06-01

History of hematopoietic stem cell transplantations in Poland begins in early 1980s; the 1st bone marrow allotransplantation was performed in 1983 in the Central Clinical Hospital of the Military Medical Academy in Warsaw. Following years brought the 1st autologous stem cell transplantations. Ten years later, unrelated bone marrow transplantation was performed for the 1st time by the team of the Hematology and Blood and Marrow Transplantation Unit in Katowice. Since then, hematopoietic stem cell transplantation developed to be standard procedure and one of the most important therapies applied in leukemia treatment. The number of allotransplantations in Poland has grown significantly in the past 2 decades, which generated new needs and problems. In 2005, based on a new Transplant Law, a National Transplants Registry was created. Its main role is to collect data (registration of procedures and follow-up data) related to every transplantation case for stem cells and tissues as well as for organs. We present statistics concerning stem cell transplantations performed in Poland, as collected in the National Transplants Registry in the years 2006-2014. There are 18 centers transplanting hematopoietic stem cells in Poland. The total number of hematopoietic stem cell transplantations performed in 2006-2014 was 3,537, with allotransplantations from relatives accounted for 1,491 and from unrelated donors for 2,046. The main indication for allotransplantation in past years was acute leukemia. Copyright © 2016 Elsevier Inc. All rights reserved.

Minor Electrocardiographic ST-T Change and Risk of Stroke in the General Japanese Population.

PubMed

Ishikawa, Joji; Hirose, Hideo; Schwartz, Joseph E; Ishikawa, Shizukiyo

2018-06-25

Minor ST-T changes are frequently observed on the electrocardiogram (ECG), but the risk of stroke associated with such changes is unclear.Methods and Results:In 10,642 subjects from the Japanese general population, we evaluated minor and major ST-T changes (major ST depression ≥0.1 mV) on ECGs obtained at annual health examinations. At baseline, minor ST-T changes were found in 10.7% of the subjects and 0.5% had major ST-T changes. Minor ST-T changes were associated with older age, female gender, higher systolic blood pressure, presence of hyperlipidemia, and use of antihypertensive medication. There were 375 stroke events during the follow-up period (128.7±28.1 months). In all subjects, minor ST-T changes (HR, 2.10; 95% CI: 1.57-2.81) and major ST-T changes (HR, 8.64; 95% CI: 4.44-16.82) were associated with an increased risk of stroke, but the stroke risk associated with minor ST-T changes had borderline significance after adjustment for conventional risk factors (P=0.055). In subgroup analysis, the risk of stroke was significantly associated with minor ST-T changes in subjects who had hyperlipidemia (HR, 1.75; 95% CI: 1.15-2.67) compared to those without hyperlipidemia (HR, 1.01; 95% CI: 0.64-1.59; P for interaction=0.016), even after adjustment for ECG-diagnosed left ventricular hypertrophy. Minor ST-T changes were particularly associated with a higher risk of stroke in subjects with hyperlipidemia and this association was independent of electrocardiographic left ventricular hypertrophy.

Measurement of Complex Sensitivity of Data Channels in Hydrophone Line Array at Very Low Frequency

DTIC Science & Technology

2015-03-25

minimum frequency at which the acoustic projectors commonly used for acoustic calibrations can transmit a useful acoustic signal. Dkt . No. 300041...Crane Water Surface 10 inch move Dkt . No. 300041 Application No. ?? REPLACEMENT SHEET? 1st DRAFT FIG. 2 62 60 66 64 70 12 66 68 2 1 11 1 12 12 2 Dkt . No...5-5 0.6 0.8 1.0 = 51ms = 0.86 Dkt . No. 300041 Application No. ?? REPLACEMENT SHEET? 1st DRAFT FIG. 4 0 1 210 10 10 -10 -5 0 5 M ag ni tu de ( dB

Annual Report on the State of the DOE National Laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-01-01

This first Annual Report to Congress on the State of the DOE National Laboratories provides a comprehensive overview of the Lab system, covering S&T programs, management and strategic planning. The Department committed to prepare this report in response to recommendations from the Congressionally mandated Commission to Review the Effectiveness of the National Energy Laboratories (CRENEL) that the Department should better communicate the value that the Laboratories provide to the Nation. We expect that future annual reports will be much more compact, building on the extensive description of the Laboratories and of the governance structures that are part of this firstmore » report.« less

Optimization of the precordial leads of the 12-lead electrocardiogram may improve detection of ST-segment elevation myocardial infarction.

PubMed

Scott, Peter J; Navarro, Cesar; Stevenson, Mike; Murphy, John C; Bennett, Johan R; Owens, Colum; Hamilton, Andrew; Manoharan, Ganesh; Adgey, A A Jennifer

2011-01-01

For the assessment of patients with chest pain, the 12-lead electrocardiogram (ECG) is the initial investigation. Major management decisions are based on the ECG findings, both for attempted coronary artery revascularization and risk stratification. The aim of this study was to determine if the current 6 precordial leads (V(1)-V(6)) are optimally located for the detection of ST-segment elevation in ST-segment elevation myocardial infarction (STEMI). We analyzed 528 (38% anterior [200], 44% inferior [233], and 18% lateral [95]) patients with STEMI with both a 12-lead ECG and an 80-lead body surface map (BSM) ECG (Prime ECG, Heartscape Technologies, Bangor, Northern Ireland). Body surface map was recorded within 15 minutes of the 12-lead ECG during the acute event and before revascularization. ST-segment elevation of each lead on the BSM was compared with the corresponding 12-lead precordial leads (V(1)-V(6)) for anterior STEMI. In addition, for lateral STEMI, leads I and aVL of the BSM were also compared; and limb leads II, III, aVF of the BSM were compared with inferior unipolar BSM leads for inferior STEMI. Leads with the greatest mean ST-segment elevation were selected, and significance was determined by analysis of variance of the mean ST segment. For anterior STEMI, leads V(1), V(2), 32, 42, 51, and 57 had the greatest mean ST elevation. These leads are located in the same horizontal plane as that of V(1) and V(2). Lead 32 had a significantly greater mean ST elevation than the corresponding precordial lead V(3) (P = .012); and leads 42, 51, and 57 were also significantly greater than corresponding leads V(4), V(5), V(6), respectively (P < .001). Similar findings were also found for lateral STEMI. For inferior STEMI, the limb leads of the BSM (II, III, and aVF) had the greatest mean ST-segment elevation; and lead III was significantly superior to the inferior unipolar leads (7, 17, 27, 37, 47, 55, and 61) of the BSM (P < .001). Leads placed on a horizontal strip, in line with leads V(1) and V(2), provided the optimal placement for the diagnosis of anterior and lateral STEMI and appear superior to leads V(3), V(4), V(5), and V(6). This is of significant clinical interest, not only for ease and replication of lead placement but also may lead to increased recruitment of patients eligible for revascularization with none or borderline ST-segment elevation on the initial 12-lead ECG. Copyright © 2011 Elsevier Inc. All rights reserved.

An Analysis of Total Quality Management in Aeronautical Systems Division

DTIC Science & Technology

1991-09-01

Annual Review ..... ......... . 3-51 Disease 4: Mobility of Top Management ................... .3-52 Disease 5: Running a Company on Visible Figures...range Planning .................... 5-4 Merit Rating Systems and Annual Evaluation of Performance .. ..... ........... 5-4 Mobility of Management...generations of careful quality-conscious buyers. The indus- trial engine ran on the talents of designers, packagers, and advertisers . Turning out new

North Dakota's forest resources in 2005

Treesearch

David E. Haugen; Gary J. Brand; Michael Kangas

2006-01-01

This report completes the first 5 years of the annual forest inventory in North Dakota and presents estimates of forest area, volume, and biomass for 2005. It is part of the national effort of annual forest inventory authorized by the 1998 Farm Bill. Sine the third forest inventory, in 1994, total forest land area has increased by 51,000 acres. Private forest land...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2014 CFR

2014-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2012 CFR

2012-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2010 CFR

2010-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2011 CFR

2011-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

40 CFR 52.35 - What are the requirements of the Federal Implementation Plans (FIPs) for the Clean Air Interstate...

Code of Federal Regulations, 2013 CFR

2013-07-01

... nitrogen oxides? 52.35 Section 52.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... (CAIR) relating to emissions of nitrogen oxides? (a)(1) The Federal CAIR NOX Annual Trading Program... provisions that relate to annual emissions of nitrogen oxides (NOX). Each State that is described in § 51.123...

Adaptive Logistics Support for Combat

DTIC Science & Technology

1990-09-01

parts allocation within budget constraints, or for achieving required operational availability with minimum Cost are described. Accession For NTIS GRA&I...is, then max (AC + Ss7 )- a#,(.Q(T’) I St ci Si: B (5.5) Si 0 51 VI. CONCLUSIONS AND RECOMMENDATIONS In this thesis several mathematical models for

The Whole Child. Info Brief, Number 51

ERIC Educational Resources Information Center

McCloskey, Molly

2007-01-01

What is the best educational approach to prepare today's students to become tomorrow's leaders? How do we equip today's students with 21st century skills necessary for success? These important questions face parents, educators, policymakers, and communities. ASCD proposes a new whole child approach, supported by research, to provide the foundation…

Island of Oahu, State of Hawaii, as seen from the Apollo 7 spacecraft

NASA Technical Reports Server (NTRS)

1968-01-01

Island of Oahu, State of Hawaii, as seen from the Apollo 7 spacecraft during its 51st revolution of the earth. Photographed from an altitude of 122 nautical miles, at ground elapsed time of 81 hours. Diamond Head and Pearl Harbor are clearly visible.

Are We Social Engineers?

ERIC Educational Resources Information Center

Fetter, Jean H.; Spencer, Ted; Fitzsimmons, Bill; Hoganson, Mary Lee

2006-01-01

This article from the "Journal of College Admission's" Special Diversity Issue (which in its entirety won the 1997 Muir Award), presents a compilation of three speeches, given at the 51st National Conference in Boston, Massachusetts. The preface, by Mary Lee Hoganson, serves to bind the three speeches together under the cohesive question, "Are…

Exploitability Assessment with TEASER

DTIC Science & Technology

2017-05-01

dear friends Leo St. Amour, Ricky T, Andreas Kellas, and Paul Deardorff for taking time out of their busy schedules to proofread this thesis. Last, I...in glibc mal- loc function. Marked as severe on Chromium, but no known exploit Table 5.1: Summary of results of TEASER compared with other tools and

Presentation on POU Systems for Compliance

EPA Science Inventory

Presentation being given at the Water Quality Association Annual Conference, Las Vegas, NV, April 21-22, 2015. Information being presented on the use of POU/POE systems for the compliance to EPA drinking water regulations. Information will included arsenic compliance data by St...

Annual report of the National Advisory Committee for Aeronautics (21st).administrative report including Technical Report nos. 508 to 541

NASA Technical Reports Server (NTRS)

1936-01-01

Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

42 CFR 493.941 - Hematology (including routine hematology and coagulation).

Code of Federal Regulations, 2013 CFR

2013-10-01

... of a laboratory's responses for qualitative and quantitative hematology tests or analytes, the...) of this section. (2) For quantitative hematology tests or analytes, the program must determine the...

42 CFR 493.941 - Hematology (including routine hematology and coagulation).

Code of Federal Regulations, 2014 CFR

2014-10-01

... of a laboratory's responses for qualitative and quantitative hematology tests or analytes, the...) of this section. (2) For quantitative hematology tests or analytes, the program must determine the...

42 CFR 493.941 - Hematology (including routine hematology and coagulation).

Code of Federal Regulations, 2010 CFR

2010-10-01

... of a laboratory's responses for qualitative and quantitative hematology tests or analytes, the...) of this section. (2) For quantitative hematology tests or analytes, the program must determine the...

42 CFR 493.941 - Hematology (including routine hematology and coagulation).

Code of Federal Regulations, 2012 CFR

2012-10-01

... of a laboratory's responses for qualitative and quantitative hematology tests or analytes, the...) of this section. (2) For quantitative hematology tests or analytes, the program must determine the...

42 CFR 493.941 - Hematology (including routine hematology and coagulation).

Code of Federal Regulations, 2011 CFR

2011-10-01

... of a laboratory's responses for qualitative and quantitative hematology tests or analytes, the...) of this section. (2) For quantitative hematology tests or analytes, the program must determine the...

Institute for the Study of Human Capabilities: Summary Descriptions of Research for the Period June 1, 1990 through May 31, 1991

DTIC Science & Technology

1991-07-23

and H. Schroeder (eds.), Proceedings of the International Fechner Symposium. Am- sterdam: North Holland. VanZandt, T. and Townsend, J.R. (Submitted...Smith, L. B. (Forthcoming). A connectionist model of the development of the notion of sameness. Thirteenth Annual Conference of the Cognitive Science...1987). A detection theory method for the analysis of visual and auditory displays. Proceedings of the 31st Annual Meeting of the Human Factors

Eosinophilic pustular folliculitis associated with hematological disorders: A report of two cases and review of Japanese literature.

PubMed

Takamura, Saori; Teraki, Yuichi

2016-04-01

Eosinophilic pustular folliculitis (EPF) occurs in patients with hematological disorders. However, clinical information about hematological disorder-associated EPF is scarce. We report two cases of EPF associated with mantle cell lymphoma and reviewed the available published work on Japanese cases. We identified a total of 23 Japanese cases, including the two cases reported here, who had hematological disorder-associated EPF. Fourteen cases were associated with treatment for hematological malignancies (transplantation-related EPF) and nine cases were associated with hematological malignancies themselves (hematological malignancy-related EPF). Although the skin eruption was clinically indistinguishable between the two subtypes, transplantation-related EPF occurred on the face and trunk of young and middle-aged men and women, whereas hematological malignancy-related EPF occurred mostly on the face of older men. Peripheral blood eosinophilia was more frequently observed in transplantation-related EPF. These observations suggest variations among patients with EPF associated with hematological disorders. © 2015 Japanese Dermatological Association.

ST-Segment Elevation Myocardial Infarction with Acute Stent Thrombosis Presenting as Intractable Hiccups: An Unusual Case

PubMed Central

Zhang, Fan; Tongo, Nosakhare Douglas; Hastings, Victoria; Kanzali, Parisa; Zhu, Ziqiang; Chadow, Hal; Rafii, Shahrokh E.

2017-01-01

Patient: Male, 51 Final Diagnosis: ST-segment elevation myocardial infarction with acute stent thrombosis Symptoms: Chest pain • hiccups Medication: — Clinical Procedure: — Specialty: Cardiology Objective: Unusual clinical course Background: Acute coronary syndrome (ACS) can present with atypical chest pain or symptoms not attributed to heart disease, such as indigestion. Hiccups, a benign and self-limited condition, can become persistent or intractable with overlooked underlying etiology. There are various causes of protracted hiccups, including metabolic abnormalities, psychogenic disorders, malignancy, central nervous system pathology, medications, pulmonary disorders, or gastrointestinal etiologies. It is rarely attributed to cardiac disease. Case Report: We report a case of intractable hiccups in a 51-year-old male with cocaine related myocardial infarction (MI) before and after stent placement. Coronary angiogram showed in-stent thrombosis of the initial intervention. Following thrombectomy, balloon angioplasty, and stent, the patient recovered well without additional episodes of hiccups. Although hiccups are not known to present with a predilection for a particular cause of myocardial ischemia, this case may additionally be explained by the sympathomimetic effects of cocaine, which lead to vasoconstriction of coronary arteries. Conclusions: Hiccups associated with cardiac enzyme elevation and EKG ST-segment elevation before and after percutaneous coronary intervention (PCI) maybe a manifestation of acute MI with or without stent. The fact that this patient was a cocaine user may have contributed to the unique presentation. PMID:28455489

Imatinib mesylate, the first molecularly targeted gene suppressor.

PubMed

Pindolia, Vanita K; Zarowitz, Barbara J

2002-10-01

To review the pharmacology, pharmacokinetics, efficacy, safety, and drug-drug and drug-food interactions of imatinib and the economic considerations of imatinib in the treatment of chronic myeloid leukemia (CML). Literature accessed through MEDLINE (January 1970-January 2002), abstracts from the 2001 annual meetings of the American Society of Clinical Oncology and the American Society of Hematology, imatinib product labeling, and additional studies or abstracts identified from the bibliographies of the reviewed literature were used to compile data. Key search terms were allogeneic bone marrow transplant and stem cell transplant, chronic myeloid leukemia, imatinib, interferon, Gleevec, leukemia, gastrointestinal stromal tumors, STI-571, and tyrosine kinase inhibitors. Imatinib is a distinctively characteristic drug targeted toward inhibition of tyrosine kinase activity. Imatinib is indicated for the treatment of patients with CML who failed interferon (IFN)-alpha therapy and for the treatment of patients with gastrointestinal stromal tumors (GISTs) expressing the tyrosine kinase receptor c-kit. Imatinib produces positive short-term hematologic and cytogenetic responses in patients with CML; short-term positive objective responses have been shown for patients with GISTs. To our knowledge, there are no controlled trials demonstrating long-term safety, improvement in disease-related symptoms, or increased survival with imatinib. Serious adverse effects requiring dosage decreases and/or therapy termination are edema, hepatotoxicity, and hematologic toxicity. Imatinib also has been found to inhibit tyrosine kinases involved in the growth of other malignancies. The role of imatinib in tumors that express a tyrosine kinase is constantly evolving with new research results. Imatinib therapy should be limited to patients whose tumor growth is related to a genetically defective tyrosine kinase. In cases of CML, imatinib should be further limited to patients who have tried and failed IFN-alpha therapy or who are not candidates for an allogeneic stem cell transplant.

Interspecies variation in the susceptibility of adult Pacific salmon to toxic urban stormwater runoff.

PubMed

McIntyre, Jenifer K; Lundin, Jessica I; Cameron, James R; Chow, Michelle I; Davis, Jay W; Incardona, John P; Scholz, Nathaniel L

2018-07-01

Adult coho salmon (Oncorhynchus kisutch) prematurely die when they return from the ocean to spawn in urban watersheds throughout northwestern North America. The available evidence suggests the annual mortality events are caused by toxic stormwater runoff. The underlying pathophysiology of the urban spawner mortality syndrome is not known, and it is unclear whether closely related species of Pacific salmon are similarly at risk. The present study co-exposed adult coho and chum (O. keta) salmon to runoff from a high traffic volume urban arterial roadway. The spawners were monitored for the familiar symptoms of the mortality syndrome, including surface swimming, loss of orientation, and loss of equilibrium. Moreover, the hematology of both species was profiled by measuring arterial pH, blood gases, lactate, plasma electrolytes, hematocrit, and glucose. Adult coho developed behavioral symptoms within a few hours of exposure to stormwater. Various measured hematological parameters were significantly altered compared to coho controls, indicating a blood acidosis and ionoregulatory disturbance. By contrast, runoff-exposed chum spawners showed essentially no indications of the mortality syndrome, and measured blood hematological parameters were similar to unexposed chum controls. We conclude that contaminant(s) in urban runoff are the likely cause of the disruption of ion balance and pH in coho but not chum salmon. Among the thousands of chemicals in stormwater, future forensic analyses should focus on the gill or cardiovascular system of coho salmon. Because of their distinctive sensitivity to urban runoff, adult coho remain an important vertebrate indicator species for degraded water quality in freshwater habitats under pressure from human population growth and urbanization. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Weldon Spring, Missouri, Site Annual Report for Calendar Year 2015 June 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Starr, Ken; Deyo, Yvonne

1.1 Purpose and Scope. This report summarizes the activities, compliance status, annual inspection, and environmental monitoring results from calendar year 2015 for the Weldon Spring, Missouri, Site. The U.S. Department of Energy (DOE) prepares this annual report as part of the site’s long-term surveillance and maintenance (LTS&M) activities, in accordance with the requirements of the Long-Term Surveillance and Maintenance Plan for the Weldon Spring, Missouri, Site (LTS&M Plan) (DOE 2008a) and the Federal Facility Agreement for the Weldon Spring Site (DOE 2006). The Weldon Spring site is a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) site. 1.2 Site Description.more » The Weldon Spring site is located in St. Charles County, Missouri, about 30 miles west of St. Louis, Missouri (Figure 1). The site comprises two geographically distinct, DOE-owned properties: the former Weldon Spring Chemical Plant and Raffinate Pit sites (Chemical Plant) and the former Weldon Spring Quarry (Quarry). The former Chemical Plant is located about 2 miles southwest of the junction of Missouri State Route 94 and Interstate 64. The Quarry is about 4 miles southwest of the former Chemical Plant. Both sites are accessible from Missouri State Route 94. During the early 1940s, the Department of the Army acquired 17,232 acres of private land in St. Charles County for the construction of the Weldon Spring Ordnance Works facility. The former Ordnance Works site has since been divided into several contiguous areas under different ownership, as depicted in Figure 2. Current land use of the former Ordnance Works site includes the former Chemical Plant and Quarry, the U.S. Army Reserve Weldon Spring Training Area, the Missouri Department of Conservation (MDC), the Missouri Department of Natural Resources (MDNR) Division of State Parks (MDNR-Parks), Francis Howell High School, a St. Charles County highway maintenance (formerly Missouri Department of Transportation [MoDOT]) facility, the Public Water Supply District No. 2 water supply facility, the St. Charles County law enforcement training center, the village of Weldon Spring Heights, and a University of Missouri research park. The former Chemical Plant and Quarry areas total 228.16 acres. The Former Chemical Plant property occupies 219.50 acres, and the Quarry occupies 8.66 acres.« less

Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies

PubMed Central

2012-01-01

Background Intensified conditioning regimens (increasing the intensity of standard myeloablative conditioning) for hematological malignancies in allogeneic hematopoietic stem cell transplantation (allo-HSCT) could reduce the relapse rate of the underlying disease, but it might simultaneously increase the transplant-related mortality including the mortality of infections. To explore whether intensified conditioning affected Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections, 185 patients undergoing allo-HSCT were enrolled. Methods A total of 104 cases received standard and 81 intensified conditioning. Cyclosporine A (CsA) withdrawal and/or donor lymphocyte infusion (DLI) were conducted in high-risk patients. The EBV-DNA and CMV-DNA levels of blood were monitored regularly by quantitative real-time polymerase chain reaction (RQ-PCR) and immune reconstitution of recipients were analyzed by flow cytometry. Results The 3-year cumulative incidence of EBV viremia, EBV-associated diseases and mortality of EBV-associated diseases were 25.3% ± 4.6%, 10.5% ± 3.4% and 0.0% ± 0.0% in the standard group, compared with 45.6% ± 6.5%, 26.0% ±5.3% and 7.3% ± 3.1% in the intensified group (P = 0.002, P = 0.002, P = 0.008). The 3-year cumulative incidence of CMV viremia and CMV-associated diseases, mortality of CMV-associated diseases and incidence of bacterial and fungal infections were similar between the two groups (P = 0.855, P = 0.581, P = 0.933, P = 0.142, P = 0.182, respectively). Multivariate analysis showed that intensified conditioning was one of the risk factors for EBV viremia and EBV-associated diseases (P = 0.037, P = 0.037), but it had no effects on CMV infections. The percentage of CD4+ T cells and CD4+/CD8+ ratio at 3 months post-transplantation were lower in the intensified group (P = 0.032, P = 0.022). The 3-year OS and DFS in the standard group were 62.2% ± 5.8% and 60.6% ± 5.6%, compared with 51.6% ± 6.2% and 51.1% ± 5.9% in the intensified group (P = 0.029, P = 0.063). Conclusions Intensified conditioning represents a promising approach for high-risk hematological malignancies, although it affects early immune reconstitution of recipients and increases the incidence and mortality of EBV infections. PMID:22856463

40 CFR 51.30 - When does my state report which emissions data to EPA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... the 2009 inventory year and must be submitted to EPA within 12 months, i.e., by December 31, 2010. (2... for every third inventory year the annual (12-month) emissions of all pollutants listed in § 51.15(a... first 3-year cycle inventory will be for the 2011 inventory and must be submitted to us within 12 months...

Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats.

PubMed

Pagliassotti, M J; Prach, P A

1995-09-01

To determine the effects of the amount of sucrose in the diet on insulin-stimulated glucose metabolism, euglycemic hyperinsulinemic clamps were performed on male Wistar rats after one of the following dietary treatments (n = 6-8/treatment): 1) high-starch diet (68% of total energy) for 8 wk (ST8), 16 wk (ST16), or 30 wk (ST30); 2) high-sucrose diet (68% of total energy) for 8 wk (SU8), 16 wk (SU16), or 30 wk (SU30); or 3) low-sucrose diet (18% of total energy) for 8 wk (SUL8), 16 wk (SUL16), or 30 wk (SUL30). Body weights were similar in starch- and sucrose-fed rats at 8 wk (502 +/- 9 g), 16 wk (563 +/- 10 g), and 30 wk (607 +/- 26 g). The glucose infusion rate (mumol.g-1.min-1) required to maintain similar glycemia during clamps was 73.1 +/- 8.8 in ST8, 29.7 +/- 4.9 in SU8 (P < 0.05 vs. ST8 and SUL8), and 76.4 +/- 8.2 in SUL8; 69.9 +/- 8.1 in ST16, 35.1 +/- 5.1 in SU16 (P < 0.05 vs. ST16 and SUL16), and 63.2 +/- 6.5 in SUL16; and 65.4 +/- 7.7 in ST30, 26.0 +/- 5.3 (P < 0.05 vs. ST30), and 36.3 +/- 6.0 in SUL30 (P < 0.05 vs. ST30). Impaired suppression of hepatic glucose production accounted for 43, 39, and 34% of the decrease in the glucose infusion rate in SU8 compared with ST8, SU16 compared with ST16, and SU30 compared with ST30, respectively, but 78% in SUL30 compared with ST30. These results suggest that both high- and low-sucrose diets can produce insulin resistance in young rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Most atolls will be uninhabitable by the mid-21st century because of sea-level rise exacerbating wave-driven flooding

USGS Publications Warehouse

Storlazzi, Curt; Gingerich, Stephen B.; van Dongeren, Ap; Cheriton, Olivia; Swarzenski, Peter W.; Quataert, Ellen; Voss, Clifford I.; Field, Donald W.; Annamalai, Hariharasubramanian; Piniak, Greg A.; McCall, Robert T.

2018-01-01

Sea levels are rising, with the highest rates in the tropics, where thousands of low-lying coral atoll islands are located. Most studies on the resilience of these islands to sea-level rise have projected that they will experience minimal inundation impacts until at least the end of the 21st century. However, these have not taken into account the additional hazard of wave-driven overwash or its impact on freshwater availability. We project the impact of sea-level rise and wave-driven flooding on atoll infrastructure and freshwater availability under a variety of climate change scenarios. We show that, on the basis of current greenhouse gas emission rates, the nonlinear interactions between sea-level rise and wave dynamics over reefs will lead to the annual wave-driven overwash of most atoll islands by the mid-21st century. This annual flooding will result in the islands becoming uninhabitable because of frequent damage to infrastructure and the inability of their freshwater aquifers to recover between overwash events. This study provides critical information for understanding the timing and magnitude of climate change impacts on atoll islands that will result in significant, unavoidable geopolitical issues if it becomes necessary to abandon and relocate low-lying island states.

Projected changes in significant wave height toward the end of the 21st century: Northeast Atlantic

NASA Astrophysics Data System (ADS)

Aarnes, Ole Johan; Reistad, Magnar; Breivik, Øyvind; Bitner-Gregersen, Elzbieta; Ingolf Eide, Lars; Gramstad, Odin; Magnusson, Anne Karin; Natvig, Bent; Vanem, Erik

2017-04-01

Wind field ensembles from six CMIP5 models force wave model time slices of the northeast Atlantic over the last three decades of the 20th and the 21st centuries. The future wave climate is investigated by considering the RCP4.5 and RCP8.5 emission scenarios. The CMIP5 model selection is based on their ability to reconstruct the present (1971-2000) extratropical cyclone activity, but increased spatial resolution has also been emphasized. In total, the study comprises 35 wave model integrations, each about 30 years long, in total more than 1000 years. Here annual statistics of significant wave height are analyzed, including mean parameters and upper percentiles. There is general agreement among all models considered that the mean significant wave height is expected to decrease by the end of the 21st century. This signal is statistically significant also for higher percentiles, but less evident for annual maxima. The RCP8.5 scenario yields the strongest reduction in wave height. The exception to this is the north western part of the Norwegian Sea and the Barents Sea, where receding ice cover gives longer fetch and higher waves. The upper percentiles are reduced less than the mean wave height, suggesting that the future wave climate has higher variance than the historical period.

Most atolls will be uninhabitable by the mid-21st century because of sea-level rise exacerbating wave-driven flooding.

PubMed

Storlazzi, Curt D; Gingerich, Stephen B; van Dongeren, Ap; Cheriton, Olivia M; Swarzenski, Peter W; Quataert, Ellen; Voss, Clifford I; Field, Donald W; Annamalai, Hariharasubramanian; Piniak, Greg A; McCall, Robert

2018-04-01

Sea levels are rising, with the highest rates in the tropics, where thousands of low-lying coral atoll islands are located. Most studies on the resilience of these islands to sea-level rise have projected that they will experience minimal inundation impacts until at least the end of the 21st century. However, these have not taken into account the additional hazard of wave-driven overwash or its impact on freshwater availability. We project the impact of sea-level rise and wave-driven flooding on atoll infrastructure and freshwater availability under a variety of climate change scenarios. We show that, on the basis of current greenhouse gas emission rates, the nonlinear interactions between sea-level rise and wave dynamics over reefs will lead to the annual wave-driven overwash of most atoll islands by the mid-21st century. This annual flooding will result in the islands becoming uninhabitable because of frequent damage to infrastructure and the inability of their freshwater aquifers to recover between overwash events. This study provides critical information for understanding the timing and magnitude of climate change impacts on atoll islands that will result in significant, unavoidable geopolitical issues if it becomes necessary to abandon and relocate low-lying island states.

Most atolls will be uninhabitable by the mid-21st century because of sea-level rise exacerbating wave-driven flooding

PubMed Central

2018-01-01

Sea levels are rising, with the highest rates in the tropics, where thousands of low-lying coral atoll islands are located. Most studies on the resilience of these islands to sea-level rise have projected that they will experience minimal inundation impacts until at least the end of the 21st century. However, these have not taken into account the additional hazard of wave-driven overwash or its impact on freshwater availability. We project the impact of sea-level rise and wave-driven flooding on atoll infrastructure and freshwater availability under a variety of climate change scenarios. We show that, on the basis of current greenhouse gas emission rates, the nonlinear interactions between sea-level rise and wave dynamics over reefs will lead to the annual wave-driven overwash of most atoll islands by the mid-21st century. This annual flooding will result in the islands becoming uninhabitable because of frequent damage to infrastructure and the inability of their freshwater aquifers to recover between overwash events. This study provides critical information for understanding the timing and magnitude of climate change impacts on atoll islands that will result in significant, unavoidable geopolitical issues if it becomes necessary to abandon and relocate low-lying island states. PMID:29707635

Proceedings, 21st U.S. Department of Agriculture interagency research forum on invasive species 2010

Treesearch

Katherine A McManus; Kurt W. Gottschalk

2010-01-01

Contains abstracts and papers of 95 oral and poster presentations on invasive species biology, molecular biology, ecology, impacts, and management presented at the annual U.S. Department of Agriculture Interagency Research Forum on Invasive Species.

Population Structure and Antimicrobial Resistance Profiles of Streptococcus suis Serotype 2 Sequence Type 25 Strains.

PubMed

Athey, Taryn B T; Teatero, Sarah; Takamatsu, Daisuke; Wasserscheid, Jessica; Dewar, Ken; Gottschalk, Marcelo; Fittipaldi, Nahuel

2016-01-01

Strains of serotype 2 Streptococcus suis are responsible for swine and human infections. Different serotype 2 genetic backgrounds have been defined using multilocus sequence typing (MLST). However, little is known about the genetic diversity within each MLST sequence type (ST). Here, we used whole-genome sequencing to test the hypothesis that S. suis serotype 2 strains of the ST25 lineage are genetically heterogeneous. We evaluated 51 serotype 2 ST25 S. suis strains isolated from diseased pigs and humans in Canada, the United States of America, and Thailand. Whole-genome sequencing revealed numerous large-scale rearrangements in the ST25 genome, compared to the genomes of ST1 and ST28 S. suis strains, which result, among other changes, in disruption of a pilus island locus. We report that recombination and lateral gene transfer contribute to ST25 genetic diversity. Phylogenetic analysis identified two main and distinct Thai and North American clades grouping most strains investigated. These clades also possessed distinct patterns of antimicrobial resistance genes, which correlated with acquisition of different integrative and conjugative elements (ICEs). Some of these ICEs were found to be integrated at a recombination hot spot, previously identified as the site of integration of the 89K pathogenicity island in serotype 2 ST7 S. suis strains. Our results highlight the limitations of MLST for phylogenetic analysis of S. suis, and the importance of lateral gene transfer and recombination as drivers of diversity in this swine pathogen and zoonotic agent.

Population Structure and Antimicrobial Resistance Profiles of Streptococcus suis Serotype 2 Sequence Type 25 Strains

PubMed Central

Athey, Taryn B. T.; Teatero, Sarah; Takamatsu, Daisuke; Wasserscheid, Jessica; Dewar, Ken; Gottschalk, Marcelo; Fittipaldi, Nahuel

2016-01-01

Strains of serotype 2 Streptococcus suis are responsible for swine and human infections. Different serotype 2 genetic backgrounds have been defined using multilocus sequence typing (MLST). However, little is known about the genetic diversity within each MLST sequence type (ST). Here, we used whole-genome sequencing to test the hypothesis that S. suis serotype 2 strains of the ST25 lineage are genetically heterogeneous. We evaluated 51 serotype 2 ST25 S. suis strains isolated from diseased pigs and humans in Canada, the United States of America, and Thailand. Whole-genome sequencing revealed numerous large-scale rearrangements in the ST25 genome, compared to the genomes of ST1 and ST28 S. suis strains, which result, among other changes, in disruption of a pilus island locus. We report that recombination and lateral gene transfer contribute to ST25 genetic diversity. Phylogenetic analysis identified two main and distinct Thai and North American clades grouping most strains investigated. These clades also possessed distinct patterns of antimicrobial resistance genes, which correlated with acquisition of different integrative and conjugative elements (ICEs). Some of these ICEs were found to be integrated at a recombination hot spot, previously identified as the site of integration of the 89K pathogenicity island in serotype 2 ST7 S. suis strains. Our results highlight the limitations of MLST for phylogenetic analysis of S. suis, and the importance of lateral gene transfer and recombination as drivers of diversity in this swine pathogen and zoonotic agent. PMID:26954687

[Multilocus sequence-typing for characterization of Moscow strains of Haemophilus influenzae type b].

PubMed

Platonov, A E; Mironov, K O; Iatsyshina, S B; Koroleva, I S; Platonova, O V; Gushchin, A E; Shipulin, G A

2003-01-01

Haemophilius influenzae, type b (Hib) bacteria, were genotyped by multilocus sequence typing (MLST) using 5 loci (adk, fucK, mdh, pgi, recA). 42 Moscow Hib strains (including 38 isolates form cerebrospinal fluid of children, who had purulent meningitis in 1999-2001, and 4 strains isolated from healthy carriers of Hib), as well as 2 strains from Yekaterinburg were studied. In MLST a strain is characterized, by alleles and their combinations (an allele profile) referred to also as sequence-type (ST). 9 Sts were identified within the Russian Hib bacteria: ST-1 was found in 25 strains (57%), ST-12 was found in 8 strains (18%), ST-11 was found in 4 strains (9%) and ST-15 was found in 2 strains (4.5%); all other STs strains (13, 14, 16, 17, 51) were found in isolated cases (2.3%). A comparison of allelic profiles and of nucleotide sequences showed that 93% of Russian isolates, i.e. strain with ST-1, 11, 12, 13, 15 and 17, belong to one and the same clonal complex. 2 isolates from Norway and Sweden from among 7 foreign Hib strains studied up to now can be described as belonging to the same clonal complex; 5 Hib strains were different from the Russian ones.

Complex Population Structure and Virulence Differences among Serotype 2 Streptococcus suis Strains Belonging to Sequence Type 28

PubMed Central

Athey, Taryn B. T.; Auger, Jean-Philippe; Teatero, Sarah; Dumesnil, Audrey; Takamatsu, Daisuke; Wasserscheid, Jessica; Dewar, Ken; Gottschalk, Marcelo; Fittipaldi, Nahuel

2015-01-01

Streptococcus suis is a major swine pathogen and a zoonotic agent. Serotype 2 strains are the most frequently associated with disease. However, not all serotype 2 lineages are considered virulent. Indeed, sequence type (ST) 28 serotype 2 S. suis strains have been described as a homogeneous group of low virulence. However, ST28 strains are often isolated from diseased swine in some countries, and at least four human ST28 cases have been reported. Here, we used whole-genome sequencing and animal infection models to test the hypothesis that the ST28 lineage comprises strains of different genetic backgrounds and different virulence. We used 50 S. suis ST28 strains isolated in Canada, the United States and Japan from diseased pigs, and one ST28 strain from a human case isolated in Thailand. We report a complex population structure among the 51 ST28 strains. Diversity resulted from variable gene content, recombination events and numerous genome-wide polymorphisms not attributable to recombination. Phylogenetic analysis using core genome single-nucleotide polymorphisms revealed four discrete clades with strong geographic structure, and a fifth clade formed by US, Thai and Japanese strains. When tested in experimental animal models, strains from this latter clade were significantly more virulent than a Canadian ST28 reference strain, and a closely related Canadian strain. Our results highlight the limitations of MLST for both phylogenetic analysis and virulence prediction and raise concerns about the possible emergence of ST28 strains in human clinical cases. PMID:26375680

Social media: a tool to spread information: a case study analysis of twitter conversation at the Cardiac Society of Australia & New Zealand 61st annual scientific meeting 2013.

PubMed

Ferguson, Caleb; Inglis, Sally C; Newton, Phillip J; Cripps, Peter J S; MacDonald, Peter S; Davidson, Patricia M

2014-01-01

The World Wide Web has changed the way in which people communicate and consume information. More importantly, this innovation has increased the speed and spread of information. There has been recent increase in the percentage of cardiovascular professionals, including journals and associations using Twitter to engage with others and exchange ideas. Evaluating the reach and impact in scientific meetings is important in promoting the use of social media. This study evaluated Twitter use during the recent 61st Annual Scientific Meeting at the Cardiac Society of Australia and New Zealand. During the Cardiac Society of Australia and New Zealand 2013 61st Annual Scientific Meeting Symplur was used to curate conversations that were publicly posted with the hashtag #CSANZ2013. The hashtag was monitored with analysis focused on the influencers, latest tweets, tweet statistics, activity comparisons, and tweet activity during the conference. Additionally, Radian6 social media listening software was used to collect data. A summary is provided. There were 669 total tweets sent from 107 unique Twitter accounts during 8th August 9 a.m. to 11th August 1 p.m. This averaged nine tweets per hour and six tweets per participant. This assisted in the sharing of ideas and disseminating the findings and conclusions from presenters at the conference with a total 1,432,573 potential impressions in Twitter users tweet streams. This analysis of Twitter conversations during a recent scientific meeting highlights the significance and place of social media within research dissemination and collaboration. Researchers and clinicians should consider using this technology to enhance timely communication of findings. The potential to engage with consumers and enhance shared decision-making should be explored further.

33 CFR 165.151 - Safety Zones; Long Island Sound annual fireworks displays.

Code of Federal Regulations, 2011 CFR

2011-07-01

....5″ W; and barge two, 41°20′51.75″ N, 72°05′18.90″ W. (11) Harbor Day Fireworks Safety Zone. All... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zones; Long Island Sound... § 165.151 Safety Zones; Long Island Sound annual fireworks displays. (a) Safety Zones. The following...

33 CFR 165.151 - Safety Zones; Long Island Sound annual fireworks displays.

Code of Federal Regulations, 2010 CFR

2010-07-01

....5″ W; and barge two, 41°20′51.75″ N, 72°05′18.90″ W. (11) Harbor Day Fireworks Safety Zone. All... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zones; Long Island Sound... § 165.151 Safety Zones; Long Island Sound annual fireworks displays. (a) Safety Zones. The following...

Treatment of ovarian cancer with surgery, short-course chemotherapy and whole abdominal radiation.

PubMed

Buser, K; Bacchi, M; Goldhirsch, A; Greiner, R; Diener, P; Sessa, C; Jungi, W F; Forni, M; Leyvraz, S; Engeler, V

1996-01-01

The primary aim was to induce a high number of pCR in early (FIGO IC, IIB + C) - and advanced (FIGO III-IV) - stage ovarian cancer with a surgery plus 4 cycles of cisplatin and melphalan (PAMP) regimen. The second objective was to prevent relapse with WAR in patients in remission after chemotherapy. 218 eligible patients were treated after staging laparotomy with cisplatin 80 mg/sqm i.v. on day 1 and melphalan 12 mg/sqm i.v. on day 2 q 4 weeks. Response was verified by second-look laparotomy. WAR was carried out with the open field technique on a linear accelerator (daily dose: 1.3 Gy, total dose: 29.9 Gy) in patients with pathological or clinical CR or pathological PR with microscopical residual disease. 146/218 patients (67%, 95% CI: 61%-73%) responded to PAMP: 56 (26%) achieved pCR, 24 (11%), cCR, 56 (26%) pPR and 10 (5%) cPR (c = clinical, p = pathological). Multivariate analyses revealed that in advanced stages (92 cases in remission), the achievement of pCR was the most important factor for longer time to failure (TTF) and survival. Only 51/118 (43%) patients in remission received WAR. Early-stage patients <= 55 years were more likely to have WAR than patients older than 55 years (77% vs. 23%; p = 0.02). Advanced-stage patients with cCR were less likely to be irradiated than patients with pCR or pPR (10% vs. 51%; p = 0.003). Toxicity of PAMP was acceptable with 10% of WHO grade 4 hematologic toxicity. Acute hematological toxicity of WAR caused interruption (33%) or incompleteness (33%) of irradiation in the majority of patients. PAMP is an effective treatment for advanced ovarian cancer with a 67% response rate after 4 cycles. For the majority of patients in remission, WAR as a consolidation treatment was hardly feasible. For these patients new treatment modalities to consolidate remission are needed.

NASA-UVA Light Aerospace Alloy and Structures Technology Program (LA2ST). Research on Materials for the High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Starke, Edgar A., Jr.; Kelly, Robert G.; Scully, John R.; Stoner, Glenn E.; Wert, John A.

1997-01-01

Since 1986, the NASA-Langley Research Center has sponsored the NASA-UVa Light Alloy and Structures Technology (LA2ST) Program at the University of Virginia (UVa). The fundamental objective of the LA2ST program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures. The LA2ST program has aimed to product relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies. The scope of the LA2ST Program is broad. Research areas include: (1) Mechanical and Environmental Degradation Mechanisms in Advanced Light Metals and Composites, (2) Aerospace Materials Science, (3) Mechanics of materials for Aerospace Structures, and (4) Thermal Gradient Structures. A substantial series of semi-annual progress reports issued since 1987 documents the technical objectives, experimental or analytical procedures, and detailed results of graduate student research in these topical areas.

Factors that impact medical student and house-staff career interest in brain related specialties.

PubMed

Kamour, Abdulbaset H; Han, Dong Y; Mannino, David M; Hessler, Amy B; Kedar, Sachin

2016-10-15

There is a national shortage of physicians in brain related specialties (neurology, neurosurgery and psychiatry), with fewer students training in these specialties. This study explored socio-economic and experiential factors that determined medical trainees' interest in brain related specialties. Medical students and house-staff at a state university medical school completed a 46-item questionnaire sent as an anonymous email survey. Survey response rate was 22% (n=258). Eighty-eight (34.1%) trainees were interested in brain related specialties. Prior neuroscience experience (29.6%) and effective medical school neuroscience courses (23.9%) were identified as important by those interested in brain related specialties, while "neurophobia" was reported by 30% of those not interested. Multivariate regression model showed that effective college neuroscience course increased the likelihood for interest in brain related specialties (OR=2.28, 95% CI 1.22, 4.28). Factors which decreased the likelihood included parent's possessing professional degree (OR=0.37, 95% CI 0.17, 0.80), personal annual income>$50,000 (OR=0.40, 0.18, 0.87) and current debt level≥$100,000 (OR=0.33, 0.17, 0.64). The proportion of trainees interested in brain related specialties decreased from 51.7% (1st year medical students) to 27% (4th year students) and 25.3% among house-staff (χ(2) test of trend p=0.001). Socioeconomic (current personal debt and annual income) and experiential factors (college neuroscience course) influence a medical trainee's interest in brain related specialties. Career guidance and improved, better and early exposure to neurosciences may help mitigate trend for decreased interest in brain related specialties. Copyright © 2016 Elsevier B.V. All rights reserved.

Immobilised Sarawak Malaysia yeast cells for production of bioethanol.

PubMed

Zain, Masniroszaime Mohd; Kofli, Noorhisham Tan; Rozaimah, Siti; Abdullah, Sheikh

2011-05-01

Bioethanol production using yeast has become a popular topic due to worrying depleting worldwide fuel reserve. The aim of the study was to investigate the capability of Malaysia yeast strains isolated from starter culture used in traditional fermented food and alcoholic beverages in producing Bioethanol using alginate beads entrapment method. The starter yeast consists of groups of microbes, thus the yeasts were grown in Sabouraud agar to obtain single colony called ST1 (tuak) and ST3 (tapai). The growth in Yeast Potatoes Dextrose (YPD) resulted in specific growth of ST1 at micro = 0.396 h-1 and ST3 at micro = 0.38 h-1, with maximum ethanol production of 7.36 g L-1 observed using ST1 strain. The two strains were then immobilized using calcium alginate entrapment method producing average alginate beads size of 0.51 cm and were grown in different substrates; YPD medium and Local Brown Sugar (LBS) for 8 h in flask. The maximum ethanol concentration measured after 7 h were at 6.63 and 6.59 g L-1 in YPD media and 1.54 and 1.39 g L-1in LBS media for ST1 and ST3, respectively. The use of LBS as carbon source showed higher yield of product (Yp/s), 0.59 g g-1 compared to YPD, 0.25 g g-1 in ST1 and (Yp/s), 0.54 g g-1 compared to YPD, 0.24 g g-1 in ST3 . This study indicated the possibility of using local strains (STI and ST3) to produce bioethanol via immobilization technique with local materials as substrate.

Mapping the moral boundaries of biological engineering.

PubMed

Russ, Zachary N

2009-05-08

The following essay was written by a sophomore undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 174 students who submitted a 1000-1200 word essay to the 4th Annual Bioethics Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biological Engineering assessed and ranked the essays in a blinded process. Five semi-finalists were invited to present their essays at a session at the annual meeting of IBE in Santa Clara, CA on March 21, 2009. Five judges scored all the presentation at the annual meeting and selected Mr. Russ's contribution as the overall winner (1st Place).

Synthetic biology: enormous possibility, exaggerated perils.

PubMed

Russ, Zachary N

2008-04-25

The following essay was written by a freshman undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 94 students who submitted a 1000 to 1200 word essay to the 3rd Annual Bioethics Essay Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biological Engineering assessed and ranked the essays in a blinded process. Five semi-finalists were invited to present their essays at a session at the annual meeting of IBE in Chapel Hill, NC on March 8, 2008. Five judges scored the presentations at the annual meeting and selected Mr. Russ's contribution as the overall winner (1st Place). Below is his essay.

Mapping the moral boundaries of biological engineering

PubMed Central

Russ, Zachary N

2009-01-01

The following essay was written by a sophomore undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 174 students who submitted a 1000–1200 word essay to the 4th Annual Bioethics Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biological Engineering assessed and ranked the essays in a blinded process. Five semi-finalists were invited to present their essays at a session at the annual meeting of IBE in Santa Clara, CA on March 21, 2009. Five judges scored all the presentation at the annual meeting and selected Mr. Russ's contribution as the overall winner (1st Place). PMID:19422721

36th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2015 annual meeting.

PubMed

Gripp, Karen W; Adam, Margaret P; Hudgins, Louanne; Carey, John C

2016-07-01

The 36th Annual David W Smith Workshop on Malformations and Morphogenesis was held on August 14-19, 2015 at the Harbourtowne Conference Center in St. Michaels Maryland. The Workshop, which honors the legacy of David W Smith, brought together over 120 clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. As is the tradition of the meeting, the Workshop highlighted five themes besides mechanisms of morphogenesis: Rasopathies, Eye Malformations, Therapeutics, Prenatal Diagnosis, and Disorders of Sex Development. This Conference Report includes the abstracts presented at the 2015 Workshop. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Synthetic biology: enormous possibility, exaggerated perils

PubMed Central

Russ, Zachary N

2008-01-01

The following essay was written by a freshman undergraduate student majoring in Bioengineering at the University of Maryland, Mr. Zachary Russ. Mr. Russ was one of 94 students who submitted a 1000 to 1200 word essay to the 3rd Annual Bioethics Essay Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biological Engineering assessed and ranked the essays in a blinded process. Five semi-finalists were invited to present their essays at a session at the annual meeting of IBE in Chapel Hill, NC on March 8, 2008. Five judges scored the presentations at the annual meeting and selected Mr. Russ's contribution as the overall winner (1st Place). Below is his essay. PMID:18439286

Island of Oahu, State of Hawaii, as seen from the Apollo 7 spacecraft

NASA Image and Video Library

1968-10-14

AS7-07-1741 (14 Oct. 1968) --- Island of Oahu, State of Hawaii, as seen from the Apollo 7 spacecraft during its 51st revolution of Earth. Photographed from an altitude of 122 nautical miles, at ground elapsed time of 81 hours. Diamond Head and Pearl Harbor are clearly visible.

Power and Influence: Global Dynamics in the 21st Century

DTIC Science & Technology

2011-10-01

A93 2010) Bardhan , Pranab K. Awakening Giants, Feet of Clay: Assessing the Economic Rise of China and India. Princeton: Princeton UP, 2010. (HC...45. Lei, David. " Outsourcing and China’s Rising Economic Power." Orbis 51, no. 1 (January 2007): 21-39. Monvoisin, Virginie and Louis-Philippe

Flaxseed hull: Chemical composition and antioxidant activity during development.

PubMed

Herchi, Wahid; Al Hujaili, Abdullah D; Sakouhi, Faouzi; Sebei, Khaled; Trabelsi, Hajer; Kallel, Habib; Boukhchina, Sadok

2014-01-01

Changes in the chemical composition and antioxidant activity of flaxseed hull during maturation were investigated. P129 hull variety was studied at four maturation stages (St1, St2, St3, and St4). Significant variation in proximate composition and flaxseed hull oil characteristics were observed. A significant increase in the carbohydrates content of the hull was observed during development. The main methyl esters were linolenic acid (48.95 - 51.52 %), oleic acid (20.27-23.41%) and linoleic acid (15.62-17.70%). The highest polyunsaturated fatty acids (PUFA) were found to be 67.14 % at the first stage of maturity (St1). Flaxseed hull oil was of good quality, containing an abundance of omega-3 essential fatty acids. The iodine value increased, while the saponification value of oil decreased during seed development. The decrease in ascorbic acid content was steady. The maximum level of total phenolic acid content (128.3 mg/100 g oil) was reached at 7 DAF. The antioxidant activity of oilseed was assessed by means of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. Radical scavenging activity for green hull was 52.74% and mature hull was 69.32%.

Characteristics of Recombinant Phytase (rSt-Phy) of the Thermophilic mold Sporotrichum thermophile and its applicability in dephytinizing foods.

PubMed

Ranjan, Bibhuti; Singh, Bijender; Satyanarayana, T

2015-12-01

Sporotrichum thermophile produces very low titres of phytase (St-Phy) extracellularly, which is acidstable, thermostable, and protease insensitive with broad substrate specificity, and therefore, the gene encoding phytase (St-Phy) has been cloned and expressed in E. coli. The purified recombinant phytase (rSt-Phy) has the molecular mass of 55 kDa with Km and Vmax (calcium phytate), kcat and kcat/Km of 0.143 mM, 185.05 nmoles mg(-1)  s(-1), 5.1 × 10(3) s(-1), and 3.5 × 10(7) M(-1) s(-1), respectively. Mg(2+) and Ba(2+) display slight stimulatory effect on the enzyme, while it is inhibited by other ions to a varied extent. The enzyme is also inhibited by chaotropic agents (guanidinium hydrochloride, potassium iodide, and urea), Woodward's reagent K, and 2,3-butanedione but resistant to both pepsin and trypsin. The rSt-Phy is useful in dephytinization of tandoori and naan (unleavened flat Indian breads), and bread, liberating soluble inorganic phosphate that mitigates anti-nutrient effects of phytic acid.

Electronic Warfare / Electronic Protection (EW/EP) S&T Priority Steering Council

DTIC Science & Technology

2011-11-08

Office Office of the Assistant Secretary of Defense (Research and Engineering) NDIA 8th Annual Disruptive Technologies Conference 8 November 2011...the NDIA Disruptive Technologies Conference, November 8, 2011 Washington, DC 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17

Climate change influences on the annual onset of Lyme disease in the United States

NASA Astrophysics Data System (ADS)

Monaghan, A. J.; Moore, S. M.; Sampson, K. M.; Beard, C. B.; Eisen, R. J.

2015-12-01

Lyme disease is the most commonly reported vector-borne illness in the United States. Lyme disease occurrence is highly seasonal and the annual springtime onset of cases is modulated by meteorological conditions in preceding months. A meteorological-based empirical model for Lyme disease onset week in the United States is driven with downscaled simulations from five global climate models and four greenhouse gas emissions scenarios to project the impacts of 21st century climate change on the annual onset week of Lyme disease. Projections are made individually and collectively for the 12 eastern States where >90% of cases occur. The national average annual onset week of Lyme disease is projected to become 0.4-0.5 weeks earlier for 2025-2040 (p<0.05), and 0.7-1.9 weeks earlier for 2065-2080 (p<0.01), with the largest shifts for scenarios with the highest greenhouse gas emissions. The more southerly mid-Atlantic States exhibit larger shifts (1.0-3.5 weeks) compared to the Northeastern and upper Midwestern States (0.2-2.3 weeks) by 2065-2080. Winter and spring temperature increases primarily cause the earlier onset. Greater spring precipitation and changes in humidity partially counteract the temperature effects. The model does not account for the possibility that abrupt shifts in the life cycle of Ixodes scapularis, the primary vector of the Lyme disease spirochete Borrelia burgdorferi in the eastern United States, may alter the disease transmission cycle in unforeseen ways. The results suggest 21st century climate change will make environmental conditions suitable for earlier annual onset of Lyme disease cases in the United States with possible implications for the timing of public health interventions.

Climate change influences on the annual onset of Lyme disease in the United States.

PubMed

Monaghan, Andrew J; Moore, Sean M; Sampson, Kevin M; Beard, Charles B; Eisen, Rebecca J

2015-07-01

Lyme disease is the most commonly reported vector-borne illness in the United States. Lyme disease occurrence is highly seasonal and the annual springtime onset of cases is modulated by meteorological conditions in preceding months. A meteorological-based empirical model for Lyme disease onset week in the United States is driven with downscaled simulations from five global climate models and four greenhouse gas emissions scenarios to project the impacts of 21st century climate change on the annual onset week of Lyme disease. Projections are made individually and collectively for the 12 eastern States where >90% of cases occur. The national average annual onset week of Lyme disease is projected to become 0.4-0.5 weeks earlier for 2025-2040 (p<0.05), and 0.7-1.9 weeks earlier for 2065-2080 (p<0.01), with the largest shifts for scenarios with the highest greenhouse gas emissions. The more southerly mid-Atlantic States exhibit larger shifts (1.0-3.5 weeks) compared to the Northeastern and upper Midwestern States (0.2-2.3 weeks) by 2065-2080. Winter and spring temperature increases primarily cause the earlier onset. Greater spring precipitation and changes in humidity partially counteract the temperature effects. The model does not account for the possibility that abrupt shifts in the life cycle of Ixodes scapularis, the primary vector of the Lyme disease spirochete Borrelia burgdorferi in the eastern United States, may alter the disease transmission cycle in unforeseen ways. The results suggest 21st century climate change will make environmental conditions suitable for earlier annual onset of Lyme disease cases in the United States with possible implications for the timing of public health interventions. Copyright © 2015 Elsevier GmbH. All rights reserved.

Navy DDG-51 and DDG-1000 Destroyer Programs: Background and Issues for Congress

DTIC Science & Technology

2017-03-21

the 75th and 76th ships in the class. The 10 DDG-51s programmed for procurement in FY2013-FY2017 (in annual quantities of 3-1-2-2-2) are being...procured under the 10- ship MYP contract for FY2013-FY2017. The Navy, in its budget submission, notes this additional $1 billion in funding for the DDG...two DDG-51s requested for procurement in FY2017 at $3,393.9 million. The ships have received a total of $182.6 million in prior-year advance procurement

ECG Criteria to Differentiate Between Takotsubo (Stress) Cardiomyopathy and Myocardial Infarction.

PubMed

Frangieh, Antonio H; Obeid, Slayman; Ghadri, Jelena-Rima; Imori, Yoichi; D'Ascenzo, Fabrizio; Kovac, Marc; Ruschitzka, Frank; Lüscher, Thomas F; Duru, Firat; Templin, Christian

2016-06-13

ECG criteria differentiating Takotsubo cardiomyopathy (TTC) from mainly anterior myocardial infarction (MI) have been suggested; however, this was in small patient populations. Twelve-lead admission ECGs of consecutive 200 TTC and 200 MI patients were compared in dichotomized groups based on the presence or absence of ST-elevation MI (STEMI versus STE-TTC and non-ST elevation MI versus non ST-elevation-TTC). When comparing STEMI and STE-TTC, ST-elevation in -aVR was characteristic of STE-TTC with a sensitivity/specificity of 43% and 95%, positive predictive value (PPV) 91%, and a negative predictive value (NPV) 62% (P<0.001); when ST-elevation in -aVR is accompanied by ST-elevation in inferior leads, sensitivity/specificity were 14% and 98% (PPV was 89% and NPV 52%) (P=0.001), and 12% and 100% when associated with ST-elevation in anteroseptal leads (PPV 100%, NPV 52%) (P<0.001). On the other hand, STEMI was characterized by ST-elevation in aVR (sensitivity/specificity of 31% and 95% P<0.001, PPV 85% and NPV 59%) and ST-depression in V2-V3-V4 (sensitivity/specificity of 24% and 100% P<0.001, PPV 100% and NPV 76%). When comparing non-ST elevation MI and non ST-elevation-TTC, T-inversion in leads I-aVL-V5-V6 had a sensitivity/specificity of 17% and 97% for non ST-elevation-TTC (PPV 83% and NPV 55%) (P<0.001), and ST-elevation in -aVR with T-inversion in any lead was also specific for non ST-elevation-TTC (sensitivity/specificity of 8% and 100%, PPV 100% and NPV 53%) (P=0.006). In non-ST elevation MI patients, the presence of ST-depression in V2-V3 was specific (sensitivity/specificity of 11% and 99%, PPV 91% and NPV 51%) (P=0.01). ECG on admission can differentiate between TTC and acute MI, with high specificity and positive predictive value. URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01947621. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

European Pharmaceutical Pricing and Reimbursement--SMi's 21st Annual Meeting (October 5-6, 2015--London, UK).

PubMed

Kibble, A; D'Souza, P

2015-10-01

Translating perceived market value for pharmaceutical products into a willingness to pay remains the key factor in ensuring market access and return on investment. How price is managed in the context of new market entrants or new approval settings can create complex challenges, and further complexity is added through diverse global reimbursement structures and the myriad of stakeholders involved at every step of value identification. SMi's 21st Annual Meeting on European Pricing and Reimbursement presented a program focused on the measures being taken by European healthcare systems as they seek to facilitate access to the latest treatments while delivering value for payers and patients. Supporting patient access to life-changing medicines is a challenge, and funders are responding in many different ways; however, while the pharma industry continues to focus its efforts on high cost drugs that treat diseases of the few, the disconnect will be not be resolved. The speakers and delegates at the annual meeting believe success is possible by focusing on value for patients, driven by provider experience, scale and learning. Instead of simply lowering costs, companies, providers and payers can more adequately contribute to the goals of funders as well as the treatment needs of patients. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

Can conservation tillage reduce N2O emissions on cropland transitioning to organic vegetable production?

PubMed

Chen, Guihua; Kolb, Lauren; Cavigelli, Michel A; Weil, Ray R; Hooks, Cerruti R R

2018-03-15

Nitrous oxide (N 2 O) is an important greenhouse gas and a catalyst of stratospheric ozone decay. Agricultural soils are the source of 75% of anthropogenic N 2 O emissions globally. Recently, significant attention has been directed at examining effects of conservation tillage on carbon sequestration in agricultural systems. However, limited knowledge is available regarding how these practices impact N 2 O emissions, especially for organic vegetable production systems. In this context, a three-year study was conducted in a well-drained sandy loam field transitioning to organic vegetable production in the Mid-Atlantic coastal plain of USA to investigate impacts of conservation tillage [strip till (ST) and no-till (NT)] and conventional tillage (CT) [with black plastic mulch (CT-BP) and bare-ground (CT-BG)] on N 2 O emissions. Each year, a winter cover crop mixture (forage radish: Raphanus sativus var. longipinnatus, crimson clover: Trifolium incarnatum L., and rye: Secale cereale L.) was grown and flail-mowed in the spring. Nearly 80% of annual N 2 O-nitrogen (N) emissions occurred during the vegetable growing season for all treatments. Annual N 2 O-N emissions were greater in CT-BP than in ST and NT, and greater in CT-BG than in NT, but not different between CT-BG and CT-BP, ST and NT, or CT-BG and ST. Conventional tillage promoted N mineralization and plastic mulch increased soil temperature, which contributed to greater N 2 O-N fluxes. Though water filled porosity in NT was higher and correlated well with N 2 O-N fluxes, annual N 2 O-N emissions were lowest in NT suggesting a lack of substrates for nitrification and denitrification processes. Crop yield was lowest in NT in Year 1 and CT-BP in Year 3 but yield-scaled N 2 O-N emissions were consistently greatest in CT-BP and lowest in NT each year. Our results suggest that for coarse-textured soils in the coastal plain with winter cover crops, conservation tillage practices may reduce N 2 O emissions in organic vegetable production systems. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of age and anticonvulsants on seizure threshold during bilateral electroconvulsive therapy with brief-pulse stimulus: A chart-based analysis

PubMed Central

Nitturkar, Abhishek R.; Sinha, Preeti; Bagewadi, Virupakshappa I.; Thirthalli, Jagadisha

2016-01-01

Background: Efficacy and adverse effects of electroconvulsive therapy (ECT) depend on the extent to which the electrical stimulus exceeds patients' seizure thresholds (STs). Titration method of estimating ST is recommended. Age and co-prescribed anticonvulsants (ACs) are known to affect ST. Literature on ST in bilateral ECT (BLECT) is sparse. Objective: To explore the clinical and demographic determinants of ST in a clinically representative sample of patients prescribed with BLECT. Materials and Methods: ECT records of 640 patients who received BLECT in 2011 in an academic psychiatric setting were studied. Demographic, clinical, pharmacological, and ECT details were analyzed. As per the standard practice, during the 1st ECT session, ST was determined by titration method, starting with 30 milli-Coulombs (mC) and increasing by 30 mC and thence in steps of 60 mC. Increase in ST over up to 6th session of ECT was noted. Receiver operating characteristic curve was used to find age cut-off with high specificity for ST ≥120 mC. The associations of ST and increase in ST with the age cut-off and other clinical factors were assessed using Chi-square test and logistic regression analysis. Results: The mean age was 30.98 years (+11.23 years) and mean ST at 1st ECT session was 130.36 mC (+51.96 mC). There was significantly high positive correlation (r = 0.37, P < 0.001) between age and ST. Cut-off age of 45 years had high specificity: Only 4.6% of those older than 45 years had ST <120 mC. Higher proportion of patients on AC had ST ≥120 mC. These associations were seen even after controlling for potential confounds of each other using logistic regression analysis. The results were similar for increase in ST over the course of ECT. Sex, diagnosis, use of antipsychotics, antidepressants, lithium, and benzodiazepines (BZPs) had no effect on ST or its increase. Conclusions: For BLECT using brief-pulse stimulus, ST depends on age and use of AC. For patients above the age of 45 years, ST estimation may be started at 120 mC with least risk of using unduly higher stimulus. Other medications including BZPs have little influence on ST. PMID:27385853

Effect of age and anticonvulsants on seizure threshold during bilateral electroconvulsive therapy with brief-pulse stimulus: A chart-based analysis.

PubMed

Nitturkar, Abhishek R; Sinha, Preeti; Bagewadi, Virupakshappa I; Thirthalli, Jagadisha

2016-01-01

Efficacy and adverse effects of electroconvulsive therapy (ECT) depend on the extent to which the electrical stimulus exceeds patients' seizure thresholds (STs). Titration method of estimating ST is recommended. Age and co-prescribed anticonvulsants (ACs) are known to affect ST. Literature on ST in bilateral ECT (BLECT) is sparse. To explore the clinical and demographic determinants of ST in a clinically representative sample of patients prescribed with BLECT. ECT records of 640 patients who received BLECT in 2011 in an academic psychiatric setting were studied. Demographic, clinical, pharmacological, and ECT details were analyzed. As per the standard practice, during the 1(st) ECT session, ST was determined by titration method, starting with 30 milli-Coulombs (mC) and increasing by 30 mC and thence in steps of 60 mC. Increase in ST over up to 6(th) session of ECT was noted. Receiver operating characteristic curve was used to find age cut-off with high specificity for ST ≥120 mC. The associations of ST and increase in ST with the age cut-off and other clinical factors were assessed using Chi-square test and logistic regression analysis. The mean age was 30.98 years (+11.23 years) and mean ST at 1(st) ECT session was 130.36 mC (+51.96 mC). There was significantly high positive correlation (r = 0.37, P < 0.001) between age and ST. Cut-off age of 45 years had high specificity: Only 4.6% of those older than 45 years had ST <120 mC. Higher proportion of patients on AC had ST ≥120 mC. These associations were seen even after controlling for potential confounds of each other using logistic regression analysis. The results were similar for increase in ST over the course of ECT. Sex, diagnosis, use of antipsychotics, antidepressants, lithium, and benzodiazepines (BZPs) had no effect on ST or its increase. For BLECT using brief-pulse stimulus, ST depends on age and use of AC. For patients above the age of 45 years, ST estimation may be started at 120 mC with least risk of using unduly higher stimulus. Other medications including BZPs have little influence on ST.

12th Annual Systems Engineering Conference

DTIC Science & Technology

2009-10-29

pl em en...io n of Le sso ns L ea rn ed fr om C om pl ex S ys te m o f Sy ste m s A cq ui sit io ns D r. Ri ch ar d Tu rn er , St ev en s I ns tit ut...hn ol og y Tr an sit io n Pl an ni ng Th ro ug h th e U se o f St ag e- G at es – U pd at e M r. R an dy B ul la rd , U .S . A ir Fo

An Empirical Estimation of Underground Thermal Performance for Malaysian Climate

NASA Astrophysics Data System (ADS)

Mukhtar, Azfarizal; Zamri Yusoff, Mohd; Khai Ching, Ng

2017-12-01

In this study, the soil temperature profile was computed based on the harmonic heat transfer equations at various depths. The meteorological data ranging from January, 1st 2016 to December, 31st 2016 measured by local weather stations were employed. The findings indicted that as the soil depth increases, the temperature changes are negligible and the soil temperature is nearly equal to the mean annual air temperature. Likewise, the results have been compared with those reported by other researchers. Overall, the predicted soil temperature can be readily adopted in various engineering applications in Malaysia.

The European Hematology Association Roadmap for European Hematology Research: a consensus document.

PubMed

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-02-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

The European Hematology Association Roadmap for European Hematology Research: a consensus document

PubMed Central

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-01-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

Annual Report of the National Advisory Committee for Aeronautics (1st). [Administrative Report Including Technical Reports Nos. 1 to 7

NASA Technical Reports Server (NTRS)

1916-01-01

Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations, and a compilation of technical reports produced.

DEFINING THE CELLULAR AND MOLECULAR MECHANISMS OF TOXICANT ACTION IN THE TESTIS

EPA Science Inventory

A symposium was held at the 41st annual meeting of the Society of Toxicology with presentations that emphasized novel molecular and cellular pathways that modulate the response to testicular toxicants. The first two presentations described cellular alterations after exposure to t...

48 CFR 247.573-3 - Annual reporting requirement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

48 CFR 247.573-3 - Annual reporting requirement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

Proceedings of the Annual Military Librarians’ Workshop (21st): Resource Sharing, 27-29 September 1977

DTIC Science & Technology

1977-09-29

means of which the librarians may develop or improve individual proficiency, service and stature in librarianship . To investigate techniques by which...librarians as adninistrators and managers. DISCUSSION: The group discussed improving individual proficiency, service and stature in librarianship centered

Evaluation of freeway motorist assist program : final report, September 30, 2009.

DOT National Transportation Integrated Search

2010-02-01

This evaluation of the Motorist Assist (MA) program in St. Louis estimated that MA has an annual benefit-cost ratio (B/C) of 38.25:1 using 2009 dollars. This estimate was based on nationally accepted AASHTO methodology and was based on 1082 secondary...

Does Exposure Imitate Art: Exposure Science for 21st Century Toxicity Testing

EPA Science Inventory

This Issues Session will continue the dialog begun at the highly successful 2008 NRC session in which the Annual Meeting participants were provided an overview of the three National Academy reports addressing key issues impacting the Society and the profession of toxicology. Thes...

A method for estimating maternal and newborn lives saved from health-related investments funded by the UK government Department for International Development using the Lives Saved Tool.

PubMed

Friberg, Ingrid K; Baschieri, Angela; Abbotts, Jo

2017-11-07

In 2010, the UK Government Department for International Development (DFID) committed through its 'Framework for results for reproductive, maternal and newborn health (RMNH)' to save 50,000 maternal lives and 250,000 newborn lives by 2015. They also committed to monitoring the performance of this portfolio of investments to demonstrate transparency and accountability. Methods currently available to directly measure lives saved are cost-, time-, and labour-intensive. The gold standard for calculating the total number of lives saved would require measuring mortality with large scale population based surveys or annual vital events surveillance. Neither is currently available in all low- and middle-income countries. Estimating the independent effect of DFID support relative to all other effects on health would also be challenging. The Lives Saved Tool (LiST) is an evidence based software for modelling the effect of changes in health intervention coverage on reproductive, maternal, newborn and child mortality. A multi-country LiST-based analysis protocol was developed to retrospectively assess the total annual number of maternal and newborn lives saved from DFID aid programming in low- and middle-income countries. Annual LiST analyses using the latest program data from DFID country offices were conducted between 2013 and 2016, estimating the annual number of maternal and neonatal lives saved across 2010-2015. For each country, independent project results were aggregated into health intervention coverage estimates, with and in the absence of DFID funding. More than 80% of reported projects were suitable for inclusion in the analysis, with 151 projects analysed in the 2016 analysis. Between 2010 and 2014, it is estimated that DFID contributed to saving the lives of 15,000 women in pregnancy and childbirth with health programming and 88,000 with family planning programming. It is estimated that DFID health programming contributed to saving 187,000 newborn lives. It is feasible to estimate the overall contribution and impact of DFID's investment in RMNH from currently available information on interventions and coverage from individual country offices. This utilization of LiST, with estimated population coverage based on DFID program inputs, can be applied to similar types of datasets to quantify programme impact. The global data were used to estimate DFID's progress against the Framework for results targets to inform future programming. The identified limitations can also be considered to inform future monitoring and evaluation program design and implementation within DFID.

21st Annual Spring Research Festival Highlights Science, Celebrates Collaboration | Poster

Cancer.gov

For two days at the annual Spring Research Festival, Fort Detrick was abuzz with scientific discussion as researchers and visitors from the site’s many resident government agencies and contractors gathered to share findings and recognize collaborative research. Each year, the festival focuses on intermural scientific work, as well as challenges and discoveries in the fight against cancer and infectious diseases. Spread across three separate venues and packed with seven events that included lectures, a poster session, and a vendor expo, this year’s festival did just that.

The Co-Inheritance of Alpha-Thalassemia and Sickle Cell Anemia Is Associated with Better Hematological Indices and Lower Consultations Rate in Cameroonian Patients and Could Improve Their Survival

PubMed Central

Rumaney, Maryam Bibi; Ngo Bitoungui, Valentina Josiane; Vorster, Anna Alvera; Ramesar, Raj; Kengne, Andre Pascal; Ngogang, Jeanne; Wonkam, Ambroise

2014-01-01

Background Co-inheritance of α-thalassemia was reported to be associated with a delayed age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present study aimed to explore the correlation between α-thalassemia, hematological indices, and clinical events in these patients. Methods and Findings We studied 161 Cameroonian SCA patients and 103 controls (59.1% HbAA) with median ages of 17.5 and 23 years. RFLP-PCR was used to confirm SCA genotype and to describe haplotypes in the HBB-like genes cluster. Multiplex Gap-PCR was performed to investigate the 3.7 kb α-globin gene deletions. SNaPshot PCR, capillary electrophoresis and cycle sequencing were used for the genotyping of 10 SNPs in BCL11A, HMIP1/2, OR51B5/6 and HBG loci, known to influence HbF levels. Generalised linear regression models adjusted for age, sex and SNPs genotypes was used to investigate effects of α-thalassemia on clinical and hematological indices. The median rate of vaso-occlusive painful crisis and hospitalisations was two and one per year, respectively. Stroke was reported in eight cases (7.4%). Benin haplotype was the most prevalent (66.3%; n = 208 chromosomes). Among patients, 37.3% (n = 60) had at least one 3.7 kb deletion, compared to 10.9% (n = 6) among HbAA controls (p<0.001). Among patients, the median RBC count increased with the number of 3.7 kb deletions [2.6, 3.0 and 3.4 million/dl, with no, one and two deletions (p = 0.01)]. The median MCV decreased with the number of 3.7 kb deletion [86, 80, and 68fl, with no, one and two deletions (p<0.0001)], as well as median WBC counts [13.2, 10.5 and 9.8×109/L (p<0.0001. The co-inheritance of α-thalassemia was associated with lower consultations rate (p = 0.038). Conclusion The co-inheritance of α-thalassemia and SCA is associated with improved hematological indices, and lower consultations rate in this group of patients. This could possibly improve their survival and explain the higher proportion of α-thalassemia among patients than controls. PMID:24978191

The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum.

PubMed

Ashchyan, Hovik J; Butler, Daniel C; Nelson, Caroline A; Noe, Megan H; Tsiaras, William G; Lockwood, Stephen J; James, William D; Micheletti, Robert G; Rosenbach, Misha; Mostaghimi, Arash

2018-04-01

Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies. To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. This was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings. Adults (≥18 years) who were evaluated and diagnosed as having pyoderma gangrenosum at the Brigham and Women's and Massachusetts General Hospitals from 2000 to 2015 and the University of Pennsylvania Health System from 2006 to 2016 were included. Patient demographics, clinical features, medical comorbidities, and treatment. Of the 356 validated cases of pyoderma gangrenosum included in the study, 267 (75%) were women and 284 (84.8%) were white. The mean (SD) age at presentation was 51.6 (17.7) years. Pathergy was recorded in 100 patients (28.1%). A total of 238 patients (66.9%) had associated medical comorbidities: inflammatory bowel disease in 146 patients (41.0%); inflammatory arthritis in 73 patients (20.5%); solid organ malignant neoplasms in 23 patients (6.5%); hematologic malignant neoplasms in 21 patients (5.9%); and hematologic disorders, specifically monoclonal gammopathy of undetermined significance, myelodysplastic syndrome, and polycythemia vera in 17 patients (4.8%). When stratified by age, pathergy was more common in patients 65 years or older (36.3% vs 24.3%; P = .02). Inflammatory bowel disease was the only medical comorbidity that was more common in patients younger than 65 years (47.7% vs 26.6%; P < .001), while a number of medical comorbidities were more common in those 65 years or older, including rheumatoid arthritis (13.3% vs 6.2%; P = .03), ankylosing spondylitis (1.8% vs 0%; P = .04), solid organ malignant neoplasms (13.3% vs 3.3%; P < .001), hematologic malignant neoplasms (9.7% vs 4.1%; P = .04), and the aforementioned hematologic disorders (10.6% vs 2.1%; P < .001). Although clinical presentation in this large cohort was similar between different age groups, disease associations varied by age. The findings of this study may allow for a more focused, age-specific evaluation of patients with pyoderma gangrenosum.

Guidelines for quantifying iron overload.

PubMed

Wood, John C

2014-12-05

Both primary and secondary iron overload are increasingly prevalent in the United States because of immigration from the Far East, increasing transfusion therapy in sickle cell disease, and improved survivorship of hematologic malignancies. This chapter describes the use of historical data, serological measures, and MRI to estimate somatic iron burden. Before chelation therapy, transfusional volume is an accurate method for estimating liver iron burden, whereas transferrin saturation reflects the risk of extrahepatic iron deposition. In chronically transfused patients, trends in serum ferritin are helpful, inexpensive guides to relative changes in somatic iron stores. However, intersubject variability is quite high and ferritin values may change disparately from trends in total body iron load over periods of several years. Liver biopsy was once used to anchor trends in serum ferritin, but it is invasive and plagued by sampling variability. As a result, we recommend annual liver iron concentration measurements by MRI for all patients on chronic transfusion therapy. Furthermore, it is important to measure cardiac T2* by MRI every 6-24 months depending on the clinical risk of cardiac iron deposition. Recent validation data for pancreas and pituitary iron assessments are also presented, but further confirmatory data are suggested before these techniques can be recommended for routine clinical use. © 2014 by The American Society of Hematology. All rights reserved.

Chinese SLE treatment and research group registry: III. association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus.

PubMed

Li, Jing; Leng, Xiaomei; Li, Zhijun; Ye, Zhizhong; Li, Caifeng; Li, Xiaofeng; Zhu, Ping; Wang, Zhengang; Zheng, Yi; Li, Xiangpei; Zhang, Miaojia; Tian, Xin-Ping; Li, Mengtao; Zhao, Jiuliang; Zhang, Feng-Chun; Zhao, Yan; Zeng, Xiaofeng

2014-01-01

We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P<0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; between anti-RNP antibody, anti-SSA antibody, and pulmonary arterial hypertension (PAH); between anti-SSB antibody and hematologic involvement; and between anti-dsDNA antibody and nephropathy. APL antibody was associated with hematologic involvement, interstitial lung disease, and a lower prevalence of oral ulcerations (P<0.05). Associations were also found between anti-dsDNA antibody and a lower prevalence of photosensitivity, and between anti-SSA antibody and a lower prevalence of nephropathy (P<0.05). Most of these findings were consistent with other studies in the literature but this study is the first report on the association between anti-SSA and a lower prevalence of nephropathy. The correlations of specific autoantibodies and clinical manifestations could provide clues for physicians to predict organ damages in SLE patients. We suggest that a thorough screening of autoantibodies should be carried out when the diagnosis of SLE is established, and repeated echocardiography annually in SLE patients with anti-RNP or anti-SSA antibody should be performed.

No evidence of benefit from antibiotic lock therapy in pediatric oncology patients with central line-related bloodstream infection: results of a retrospective matched cohort study and review of the literature.

PubMed

Wolf, Joshua; Allison, Kim J; Tang, Li; Sun, Yilun; Hayden, Randall T; Flynn, Patricia M

2014-10-01

Long-term central venous catheters (CVCs) are essential to modern pediatric oncology practice, but central line-related bloodstream infection (CRBSI) is a frequent and important complication. CVC salvage is often attempted but treatment failure is common due to persistent infection, delayed catheter removal, or subsequent relapse of infection, which can be associated with significant morbidity and cost. Adjunctive antibiotic lock therapy (ALT) has been proposed to reduce the risk of treatment failure, but insufficient data are available to confirm efficacy of this intervention. We undertook a retrospective matched cohort study of ALT use for treatment of CRBSI in pediatric hematology/oncology patients at St. Jude Children's Research Hospital between 2006 and 2012. Thirty-eight eligible episodes of CRBSI treated with adjunctive ALT were identified and compared to 73 episodes treated with standard therapy (ST) alone, matched by catheter-type and organism. Overall, treatment failure was similar between ALT and ST groups (50.0 vs. 38.4%; P = 0.24), but the timing was different; in the ALT cohort, immediate CVC removal was less common (0.0 vs. 12.3%; P = 0.03) but delayed removal (4-13 days) and relapse of infection was more common (50.0 vs. 24.7%; P = 0.01). This retrospective study was unable to identify any benefit of adjunctive ALT in pediatric oncology patients with CRBSI. The available evidence does not support routine ALT use, and well-conducted prospective studies are needed. © 2014 Wiley Periodicals, Inc.

77 FR 69735 - Consumer Leasing (Regulation M)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

...The Board and the Bureau are publishing final rules amending the official interpretations and commentary for the agencies' regulations that implement the Consumer Leasing Act (CLA). Effective July 21, 2011, the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) amended the CLA by increasing the threshold for exempt consumer leases from $25,000 to $50,000 and requiring that, on or after December 31, 2011, this threshold be adjusted annually by any annual percentage increase in the Consumer Price Index for Urban Wage Earners and Clerical Workers (CPI-W). Accordingly, the exemption threshold was adjusted to $51,800 effective January 1, 2012. Based on the annual percentage increase in the CPI-W as of June 1, 2012, the Board and the Bureau are adjusting the exemption threshold from $51,800 to $53,000, effective January 1, 2013. Because the Dodd-Frank Act also requires similar adjustments in the Truth in Lending Act's threshold for exempt consumer credit transactions, the Board and the Bureau are making similar amendments to each of their respective regulations implementing the Truth in Lending Act elsewhere in the Federal Register.

77 FR 69736 - Truth in Lending (Regulation Z)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

...The Board and the Bureau are publishing final rules amending the official interpretations and commentary for the agencies' regulations that implement the Truth in Lending Act (TILA). Effective July 21, 2011, the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) amended TILA by increasing the threshold for exempt consumer credit transactions from $25,000 to $50,000 and requiring that, on or after December 31, 2011, this threshold be adjusted annually by any annual percentage increase in the Consumer Price Index for Urban Wage Earners and Clerical Workers (CPI- W). Accordingly, the exemption threshold was adjusted to $51,800 effective January 1, 2012. Based on the annual percentage increase in the CPI-W as of June 1, 2012, the Board and the Bureau are adjusting the exemption threshold from $51,800 to $53,000, effective January 1, 2013. Because the Dodd-Frank Act also requires similar adjustments in the Consumer Leasing Act's threshold for exempt consumer leases, the Board and the Bureau are making similar amendments to each of their respective regulations implementing the Consumer Leasing Act elsewhere in the Federal Register.

Distribution of sequence-based types of legionella pneumophila serogroup 1 strains isolated from cooling towers, hot springs, and potable water systems in China.

PubMed

Qin, Tian; Zhou, Haijian; Ren, Hongyu; Guan, Hong; Li, Machao; Zhu, Bingqing; Shao, Zhujun

2014-04-01

Legionella pneumophila serogroup 1 causes Legionnaires' disease. Water systems contaminated with Legionella are the implicated sources of Legionnaires' disease. This study analyzed L. pneumophila serogroup 1 strains in China using sequence-based typing. Strains were isolated from cooling towers (n = 96), hot springs (n = 42), and potable water systems (n = 26). Isolates from cooling towers, hot springs, and potable water systems were divided into 25 sequence types (STs; index of discrimination [IOD], 0.711), 19 STs (IOD, 0.934), and 3 STs (IOD, 0.151), respectively. The genetic variation among the potable water isolates was lower than that among cooling tower and hot spring isolates. ST1 was the predominant type, accounting for 49.4% of analyzed strains (n = 81), followed by ST154. With the exception of two strains, all potable water isolates (92.3%) belonged to ST1. In contrast, 53.1% (51/96) and only 14.3% (6/42) of cooling tower and hot spring, respectively, isolates belonged to ST1. There were differences in the distributions of clone groups among the water sources. The comparisons among L. pneumophila strains isolated in China, Japan, and South Korea revealed that similar clones (ST1 complex and ST154 complex) exist in these countries. In conclusion, in China, STs had several unique allelic profiles, and ST1 was the most prevalent sequence type of environmental L. pneumophila serogroup 1 isolates, similar to its prevalence in Japan and South Korea.

Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

PubMed

Sparber-Sauer, Monika; Seitz, Guido; von Kalle, Thekla; Vokuhl, Christian; Leuschner, Ivo; Scheer, Monika; Münter, Marc; Ljungman, Gustaf; Bielack, Stefan S; Niggli, Felix; Ladenstein, Ruth; Klingebiel, Thomas; Fuchs, Joerg; Koscielniak, Ewa

2018-05-01

Treatment algorithms for patients with aggressive fibromatosis (AF) are challenging. There are limited data available about the use of systemic therapy (ST) in pediatric patients with AF. Patient-, tumor-, and treatment-related factors of 90 children and adolescents with AF treated on multiple prospective trials of the Cooperative Weichteilsarkom Studiengruppe (1981-2015) were analyzed with focus on response and outcome of ST. Median age was 9.48 years (0.02-18.05). Primary resection was performed in 54 patients and ST was administered in 29 of 54 patients because of disease progression or relapse. In 35 patients, ST was the initial treatment modality. A secondary resection was performed in 21 of 35 patients after ST. A total of 64 patients received ST, mainly methotrexate and vinblastine (40%) with a median duration of 380 days. The most frequent radiological response to ST was stable disease at 3 months (39%) and partial response at 6 months (53%). Radiotherapy was administered to 15 of 90 patients. One patient remained on observation only. The 5-year overall survival was 100% and the 5-year event-free survival (EFS) was 44%. Patients who had a primary resection showed a 5-year EFS of 35% versus 59% in patients who had received primary ST (P = 0.08). Functional deficiencies as long-term sequelae following resection occurred in 11 patients. At a median follow-up of 5.05 years (0.25-14.88), complete remission was achieved in 51 patients and partial remission in 28 patients. ST seems appropriate if a primary complete resection is not feasible and at relapse/progression after resection. © 2018 Wiley Periodicals, Inc.

False Positive Stress Testing: Does Endothelial Vascular Dysfunction Contribute to ST-Segment Depression in Women? A Pilot Study.

PubMed

Sharma, Shilpa; Mehta, Puja K; Arsanjani, Reza; Sedlak, Tara; Hobel, Zachary; Shufelt, Chrisandra; Jones, Erika; Kligfield, Paul; Mortara, David; Laks, Michael; Diniz, Marcio; Bairey Merz, C Noel

2018-06-19

The utility of exercise-induced ST-segment depression for diagnosing ischemic heart disease (IHD) in women is unclear. Based on evidence that IHD pathophysiology in women involves coronary vascular dysfunction, we hypothesized that coronary vascular dysfunction contributes to exercise electrocardiography (Ex-ECG) ST-depression in the absence of obstructive CAD, so-called "false positive" results. We tested our hypothesis in a pilot study evaluating the relationship between peripheral vascular endothelial function and Ex-ECG. Twenty-nine asymptomatic women without cardiac risk factors underwent maximal Bruce protocol exercise treadmill testing and peripheral endothelial function assessment using peripheral arterial tonometry (Itamar EndoPAT 2000) to measure reactive hyperemia index (RHI). The relationship between RHI and Ex-ECG ST-segment depression was evaluated using logistic regression and differences in subgroups using two-tailed t-tests. Mean age was 54 ± 7 years, body mass index 25 ± 4 kg/m 2 , and RHI 2.51 ± 0.66. Three women (10%) had RHI less than 1.68, consistent with abnormal peripheral endothelial function, while 18 women (62%) met criteria for a positive Ex-ECG based on ST-segment depression in contiguous leads. Women with and without ST-segment depression had similar baseline and exercise vital signs, metabolic equivalents (METS) achieved, and RHI (all p>0.05). RHI did not predict ST-segment depression. Our pilot study demonstrates a high prevalence of exercise-induced ST-segment depression in asymptomatic, middle-aged, overweight women. Peripheral vascular endothelial dysfunction did not predict Ex-ECG ST-segment depression. Further work is needed to investigate the utility of vascular endothelial testing and Ex-ECG for IHD diagnostic and management purposes in women. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Analyzing temozolomide medication errors: potentially fatal.

PubMed

Letarte, Nathalie; Gabay, Michael P; Bressler, Linda R; Long, Katie E; Stachnik, Joan M; Villano, J Lee

2014-10-01

The EORTC-NCIC regimen for glioblastoma requires different dosing of temozolomide (TMZ) during radiation and maintenance therapy. This complexity is exacerbated by the availability of multiple TMZ capsule strengths. TMZ is an alkylating agent and the major toxicity of this class is dose-related myelosuppression. Inadvertent overdose can be fatal. The websites of the Institute for Safe Medication Practices (ISMP), and the Food and Drug Administration (FDA) MedWatch database were reviewed. We searched the MedWatch database for adverse events associated with TMZ and obtained all reports including hematologic toxicity submitted from 1st November 1997 to 30th May 2012. The ISMP describes errors with TMZ resulting from the positioning of information on the label of the commercial product. The strength and quantity of capsules on the label were in close proximity to each other, and this has been changed by the manufacturer. MedWatch identified 45 medication errors. Patient errors were the most common, accounting for 21 or 47% of errors, followed by dispensing errors, which accounted for 13 or 29%. Seven reports or 16% were errors in the prescribing of TMZ. Reported outcomes ranged from reversible hematological adverse events (13%), to hospitalization for other adverse events (13%) or death (18%). Four error reports lacked detail and could not be categorized. Although the FDA issued a warning in 2003 regarding fatal medication errors and the product label warns of overdosing, errors in TMZ dosing occur for various reasons and involve both healthcare professionals and patients. Overdosing errors can be fatal.

Verification and quality control of routine hematology analyzers.

PubMed

Vis, J Y; Huisman, A

2016-05-01

Verification of hematology analyzers (automated blood cell counters) is mandatory before new hematology analyzers may be used in routine clinical care. The verification process consists of several items which comprise among others: precision, accuracy, comparability, carryover, background and linearity throughout the expected range of results. Yet, which standard should be met or which verification limit be used is at the discretion of the laboratory specialist. This paper offers practical guidance on verification and quality control of automated hematology analyzers and provides an expert opinion on the performance standard that should be met by the contemporary generation of hematology analyzers. Therefore (i) the state-of-the-art performance of hematology analyzers for complete blood count parameters is summarized, (ii) considerations, challenges, and pitfalls concerning the development of a verification plan are discussed, (iii) guidance is given regarding the establishment of reference intervals, and (iv) different methods on quality control of hematology analyzers are reviewed. © 2016 John Wiley & Sons Ltd.

Drug-Induced Hematologic Syndromes

PubMed Central

Mintzer, David M.; Billet, Shira N.; Chmielewski, Lauren

2009-01-01

Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications. PMID:19960059

15 CFR 921.51 - Estuarine research guidelines.

Code of Federal Regulations, 2011 CFR

2011-01-01

... conducted in a manner consistent with Estuarine Research Guidelines developed by NOAA. (b) A summary of the... funds discussed in § 921.50(c). (c) The Estuarine Research Guidelines are reviewed annually by NOAA...

Families Created Through Surrogacy Arrangements: Parent-Child Relationships in the 1st Year of Life.

ERIC Educational Resources Information Center

Golombok, Susan; Murray, Clare; Jadva, Vasanti; MacCallum, Fiona; Lycett,Emma

2004-01-01

Findings are presented of a study of families created through surrogacy arrangements. Forty-two surrogacy families were compared with 51 egg-donation families and 80 natural-conception families on standardized interview and questionnaire measures of the psychological well-being of the parents, the quality of parent-child relationships, and infant…

Tennesse Forest Acreage Increasing

Treesearch

R. L. Johnson

1961-01-01

Tennessee has 13,432,400 acres of commercial fore st land, according to a new suvey of the State's timber resources. All together, these woodIands occupy 51 percent of the total land are a in Tennessee. The estimate includes all forest land that is producing or is capable of producing industrial wood and not withdrawn from timber utilization. An additional 263,...

Wren, Sir Christopher (1632-1723)

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

Architect and astronomer, born in East Knoyle, Wiltshire, became professor of astronomy at Gresham College, and Savilian Professor of Astronomy at Oxford. He rebuilt London after the fire of 1666, planning the entire city and rebuilding 51 churches, including St Paul's Cathedral. Newton acknowledges Wren as a mathematician in the Principia. Wren independently proved KEPLER's third law and formula...

36 CFR 1120.53 - Payment of fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accordance with the procedures described in § 1120.51. Interest charges, computed at the rate prescribed in section 3717 of title 31 U.S.C.A., will be assessed on the full amount billed starting on the 31st day following the day on which the bill was sent. (c) Advance payment or assurance of payment. (1) When an ATBCB...

36 CFR 1120.53 - Payment of fees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... accordance with the procedures described in § 1120.51. Interest charges, computed at the rate prescribed in section 3717 of title 31 U.S.C.A., will be assessed on the full amount billed starting on the 31st day following the day on which the bill was sent. (c) Advance payment or assurance of payment. (1) When an ATBCB...

National Online Meeting Proceedings (21st, New York, New York, May 16-18, 2000).

ERIC Educational Resources Information Center

Williams, Martha E., Ed.

This Proceedings contains 51 of the 68 papers reviewed and selected by the Organizing/Reviewing Committee for presentation at the National Online Meeting, 2000. The volume begins with the introductory presentation of the Program Chairman, Martha E. Williams, "Highlights of the Online Database Industry and the Internet 2000." The balance of the…

[Pemphigoid in children].

PubMed

Misery, L; Jay, P; Kanitakis, J; Chouvet, B; Cozzani, E; Faure, M; Claudy, A

1994-01-01

Bullous pemphigoid is rare during the childhood. The authors report the 51st case. Jeremie, a seven-month-old baby, had atypical bullous lesions. Histological examination, direct and indirect immunofluorescence were in favor of bullous pemphigoid. Clinical and biological features of bullous pemphigoid are similar in the adult and in the infant. First treatment is represented by corticosteroids. Evolution is generally very good.

A System Status Monitor for the National Aerospace Plane.

DTIC Science & Technology

1987-12-01

12 4.5 Remediation Function .. 17 V. Results .. .. . .. . . .. . . .. . . . . ... .... . 5.1 Test IA...5.2 Test IlB.... .. .. .. .. .. .............. .G2 . 5.3 Test IC . . . . . . ..... 5.5 Te.st ILE . 71 -N IVI ,. .**,*, 𔃻’ d* *-*-’ . d...8217*?~~** ~ % ~~ *~*%’** ~ %?, P age 5.6 Test 2A .. .. .... .... ... .... .... .... .... .... .... 73 5.7 Test213. .. ... .... .... .... ... .... .... .... ..... 7

Annual Adult Education Research Conference (AERC) Proceedings (31st, Athens, Georgia, May 18-20, 1990).

ERIC Educational Resources Information Center

Kleiber, Pam, Comp.; Tisdell, Libby, Comp.

The proceedings contains: "Extending Equality" (Armstrong); "Phenomenology of Emergent Meaning from Dialectical Questioning and Answering in Adult Learning (AL)" (Xue-Ming Bao); "Study of Structural Dimensions and Predictive Capability of Adult Attitudes toward Continuing Education Scale and Education Participation Scale" (Blunt); "Ideological and…

WATER QUALITY AND THE REPLACEMENT AND REPAIR OF DRINKING WATER INFRASTRUCTURE: THE WASHINGTON, DC CASE STUDY

EPA Science Inventory

A major challenge for society in the 21st century will be replacement, design and optimal management of urban infrastructure. It is estimated that the current world wide demand for infrastructure investment is approximately three trillion US dollars annually. Many developing coun...

Computer-Assisted Learning in Language Arts

ERIC Educational Resources Information Center

Serwer, Blanche L.; Stolurow, Lawrence M.

1970-01-01

A description of computer program segments in the feasibility and development phase of Operationally Relevant Activities for Children's Language Experience (Project ORACLE); original form of this paper was prepared by Serwer for presentation to annual meeting of New England Research Association (1st, Boston College, June 5-6, 1969). (Authors/RD)

Higher Education and Government. An Uneasy Alliance.

ERIC Educational Resources Information Center

Furniss, W. Todd, Ed.; Gardner, David P., Ed.

Leaders from government and the higher education community provide a philosophical but pragmatic discussion of such topics as curriculum, admissions, research funding, and financial support. Compiled from papers presented at the 61st annual meeting of the American Council on Education, this volume offers the viewpoints of 22 institutional…

Ferrates: Greener Oxidants with Multimodal Action in Water Treatment Technologies

EPA Science Inventory

One of the biggest challenges for humanity in the 21st century is easy access to purified and potable water. The presence of pathogens and toxins in water causes more than two million deaths annually, mostly among children under the age of five. Identifying and deploying effectiv...

Annual Report of New York State Interdepartmental Committee on Indian Affairs, 1973-74.

ERIC Educational Resources Information Center

Hathorn, John R.

The purpose and function of the New York State Interdepartmental Committee on Indian Affairs is to render, through the several state departments and agencies represented, various services to the 8 American Indian reservations (Cattaraugus, St. Regis, Tonawanda, Tuscarora, Allegany, Onandaga, Shinnecock, and Poospatuck) located within the…

New York State Interdepartmental Committee on Indian Affairs, 1968-1969. Annual Report.

ERIC Educational Resources Information Center

Hathorn, John R.

The document reports on the various services rendered by several State Departments and Divisions to the 8 Indian Reservations (Cattaraugus, Onandaga, St. Regis, Tonawanda, Tuscarora, Shinnecock, Poospatuck, and Allegany Reservations) in the geographical boundaries of New York State. A summary of existing services and future service considerations…

Vegetation productivity responds to sub-annual climate conditions across semiarid biomes

USDA-ARS?s Scientific Manuscript database

In the Southwestern United States (SW), the current prolonged warm drought is similar to the predicted future climate change scenarios for the region. This study aimed to determine patterns in vegetation response to the early 21st century drought across multiple biomes. We hypothesized that differen...

50 CFR 216.72 - Restrictions on taking.

Code of Federal Regulations, 2010 CFR

2010-10-01

... discussion of the number of seals expected to be taken annually over the next 3 years to satisfy the subsistence requirements of each island. This discussion will include an assessment of factors and conditions...) St. Paul Island—Seals may only be harvested from the following haulout areas: Zapadni, English Bay...

An Evaluation of Marine Corps Educational Credentials.

DTIC Science & Technology

1983-12-01

Recruits with the same 103 Table 17 Percent Attrition Among Male Nonprior Service Accessions Who Entered the Marine Corps between FY 1978-83 by aLevel of...dictor: It Works, But Why, (Anaheim, CA.: paper presented at the 91st Annual Convention of the American Psychological Association, August 1983

1995 AAAS annual meeting and science innovation exposition: Unity in diversity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, M.S.; Heasley, C.

1995-12-31

Abstracts are presented from the 161st National Meeting of the American Association for the advancement of Science. Topics include environmental technologies, genetics, physical science research, information management, nuclear weapon issues, and education. Individual topics have been processed separately for the United States Department of Energy databases.

Programs Needed for 2017 Take Your Child to Work Day | Poster

Cancer.gov

On Wednesday, June 28, the NCI grounds will be filled with the chatter and laughter of children for the 21st annual Take Your Child to Work Day event. Every year, the event aims to spark children’s interest in science through a variety of programs and activities.

Pacific Telecommunications Council Annual Conference Proceedings (21st, Honolulu, Hawaii, January 18-20, 1999).

ERIC Educational Resources Information Center

Pacific Telecommunications Council, Honolulu, HI.

This proceedings of the 1999 conference of the Pacific Telecommunications Council contains 134 papers divided into the following topical areas: (1) Internet, including business developments, telephony, commerce, country developments in the Asia-Pacific region, Internet deployment, and Internetworking technology; (2) policy/regulatory, including…

Donor Chimerism of B Cells and Nature Killer Cells Provides Useful Information to Predict Hematologic Relapse following Allogeneic Hematopoietic Stem Cell Transplantation.

PubMed

Jiang, Ying; Wan, Liping; Qin, Youwen; Wang, Xiaorui; Yan, Shike; Xie, Kuangcheng; Wang, Chun

2015-01-01

In this study we investigated the correlation between donor chimerism status and disease relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The chimerism of Fluorescence-activated cell sorter (FACS) sorted CD3+T lymphocytes of 153 cases, CD56+CD16+NK lymphocytes of 153 cases and CD19+B lymphocytes of 31 cases with acute B lymphoblastic leukemia (B-ALL) was analyzed post-transplant utilizing polymerase chain reaction amplification of short tandem repeats (PCR-STR). A total of 33 patients (33/153, 21.6%) had recurrent disease. The positive predictive values of declining donor chimerism for hematologic and isolated extramedullary relapse were 58.8% and 10% (P=0.018, Chi-Square). The positive predictive values of declining donor chimerism in BMB, BMT, BMNK and PBB for hematologic relapse were 11.6%, 0%, 0% and 0% under close monitoring in patients with B-ALL. Only the donor chimerism in BMB significantly decreased in the group with hematologic relapse as compared with the group without hematologic relapse (P=0.00, Independent-samples T test) in patients with B-ALL. The median drop of donor chimerism in PBT, BMT, PBNK and BMNK were 0%, 0%, 5.9% and 2.8% one or two weeks prior to hematologic relapse in patients with non-B-ALL. The donor chimerism in PBNK significantly decreased prior to hematologic relapse in the group with hematologic relapse as compared with the group without hematologic relapse (P=0.022, Independent-samples T test).These data suggest donor chimerism of BMB can be used to predict the occurrence of hematologic relapse in patients with B-ALL. Donor chimerism decrease in PBNK was associated with a somewhat increased risk of hematologic relapse in patients with non-B-ALL. Therefore, our results reveal a more effective path to individually predict for hematologic relapse by dynamic monitoring different cell lineages in different disease.

Association of sedentary time and physical activity with pain, fatigue, and impact of fibromyalgia: the al-Ándalus study.

PubMed

Segura-Jiménez, V; Borges-Cosic, M; Soriano-Maldonado, A; Estévez-López, F; Álvarez-Gallardo, I C; Herrador-Colmenero, M; Delgado-Fernández, M; Ruiz, J R

2017-01-01

We examined the association of objectively measured sedentary time (ST) and physical activity (PA) levels with pain, fatigue, and the impact of the disease in women with fibromyalgia. Four hundred and nineteen (mean age ± SD = 51.7 ± 7.6 years old) women with fibromyalgia participated. ST and PA levels (light, moderate, and moderate-to-vigorous [MVPA]) were measured with triaxial accelerometry. We assessed experimental pain with algometry and clinical pain, fatigue, and impact of fibromyalgia with a number of questionnaires. The association of ST and light PA with most of the pain- and fatigue-related outcomes and impact of fibromyalgia (all, P ≤ 0.019) was independent of moderate and vigorous PA. Furthermore, the association of vigorous PA with general and physical fatigue was independent of ST and light and moderate PA (all, P < 0.001). In conclusion, lower levels of ST or higher levels of light PA are associated with lower pain, fatigue, and the overall impact of the disease independent of moderate and vigorous PA in women with fibromyalgia. Interestingly, higher vigorous PA is independently associated with lower general and physical fatigue. These results are significant for future ST and PA intervention studies in this population. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Hyaline cartilage calcification of the first metatarsophalangeal joint is associated with osteoarthritis but independent of age and BMI.

PubMed

Hubert, Jan; Hawellek, Thelonius; Hischke, Sandra; Bertrand, Jessica; Krause, Matthias; Püschel, Klaus; Rüther, Wolfgang; Niemeier, Andreas

2016-11-15

Hyaline cartilage calcification (CC) is associated with osteoarthritis (OA) in hip and knee joints. The first metatarsophalangeal joint (1 st MTPJ) is frequently affected by OA, but it is unclear if CC occurs in the 1 st MTPJ. The aim of the present study was to analyze the prevalence of CC of the 1 st MTPJ in the general population by high-resolution digital contact radiography (DCR) and to determine its association with histological OA severity, age and body mass index (BMI). 168 metatarsal heads of 84 donors (n = 47 male, n = 37 female; mean age 62.73 years, SD ±18.8, range 20-93) were analyzed by DCR for the presence of CC. Histological OA grade (hOA) by OARSI was analyzed in the central load-bearing zone of the first metatarsal head (1 st MH). Structural equation modeling (SEM) was performed to analyze the interrelationship between CC, hOA, age and BMI. The prevalence of CC of 1 st MH was 48.8 % (41/84) (95 %-CI [37.7 %, 60.0 %]), independent of the affected side (p = 0.42), gender (p = 0.41) and BMI (p = 0.51). The mean amount of CC of one MH correlated significantly with that of the contralateral side (r s  = 0.4, 95 %-CI [0.26, 0.52], p < 0.001). The mean amount of CC (in % of total cartilage area) of the MH correlated significantly with the severity of hOA (r s  = 0.51, 95 %-CI [0.32, 0.65], p < 0.001). SEM revealed significant associations between CC and hOA (r = 0.74, p < 0.001) and between hOA and age (β = 0.62, p = 0.001), but not between CC and age (p = 0.15). There was no significant influence of BMI on either CC (p = 0.37) or hOA (p = 0.16). The observation that CC of the 1 st MH is significantly associated with the severity of OA but independent of age and BMI, suggests an intimate relationship between CC and the pathogenesis of OA, the exact nature of which will have to be explored by future studies.

OXA-Carbapenemases Present in Clinical Acinetobacter baumannii-calcoaceticus Complex Isolates from Patients in Kurdistan Region, Iraq.

PubMed

Ganjo, Aryann R; Maghdid, Delshad M; Mansoor, Isam Y; Kok, Dik J; Severin, Juliette A; Verbrugh, Henri A; Kreft, Deborah; Fatah, M H; Alnakshabandi, A A; Dlnya, Asad; Hammerum, Anette M; Ng, Kim; Goessens, Wil

2016-12-01

In addition to intrinsic resistance in Acinetobacter baumannii, many different types of acquired resistance mechanisms have been reported, including the presence of VIM and IMP metallo β-lactamases and also of bla OXA-23-like and bla OXA-58-like enzymes. In the Kurdistan region of Iraq, the multiresistant A. baumannii-calcoaceticus complex is prevalent. We characterized the different mechanisms of resistance present in clinical isolates collected from different wards and different hospitals from the Kurdistan region. One hundred twenty clinical nonduplicate A. baumannii-calcoaceticus complex isolates were collected from four hospitals between January 2012 and October 2013. The identification of the isolates was confirmed by MALDI-TOF. The susceptibility to different antibiotics was determined by disk diffusion and analyzed in accordance to EUCAST guidelines. By PCR, the presence of bla OXA-51-like , bla OXA-23-like , bla OXA-24-like , and bla OXA-58-like genes was determined as well as the presence of the insertion element ISAba1. Clonal diversity was analyzed by pulsed-field gel electrophoresis (PFGE) using the restriction enzyme ApaI and, in addition, multilocus sequence typing (MLST) was performed on a selected subset of 15 isolates. All 120 A. baumannii isolates harbored bla OXA-51-like genes. One hundred one out of 110 (92%) imipenem (IMP)-resistant A. baumannii-calcoaceticus complex isolates additionally carried the bla OXA-23-like gene and four isolates (3%) were positive for bla OXA-24-like. All 101 bla OXA-23-like -positive isolates had the ISAba1 insertion sequence, 1,600 bp upstream of the bla OXA-23-like gene. The bla OXA-58-like gene was not detected in any of the 110 IMP-resistant strains. Eight different PFGE clusters were identified and distributed over the different hospitals. MLST analysis performed on a subset of 15 representative isolates revealed the presence of the international clone ST2 (Pasteur). Besides ST2 (Pasteur), also many other STs (Pasteur) were encountered such as ST136, ST94, ST623, ST792, and ST793, all carrying the bla OXA-23 gene. In clinical A. baumannii-calcoaceticus complex isolates from Kurdistan-Iraq, the bla OXA-23 gene in combination with the upstream ISAba1 insertion element is largely responsible for carbapenem resistance. Several small clusters of identical genotypes were found from patients admitted to the same ward and during overlapping time periods, suggesting transmission within the hospital. Identification of source(s) and limiting the transmission of these strains to patients needs to be prioritized.

EDITORIAL: Annual prizes for best papers

NASA Astrophysics Data System (ADS)

2007-07-01

2006 Roberts Prize The publishers of Physics in Medicine and Biology (PMB) in association with the Institute of Physics and Engineering in Medicine (IPEM) jointly award an annual prize for an article published in PMB during the previous year. The following ten articles, listed below in chronological order, were rated the best of 2006 based on the (two or three) referees' assessments: D W Mundy et al 2006 Radiation binary targeted therapy for HER-2 positive breast cancers: assumptions, theoretical assessment and future directions Phys. Med. Biol. 51 1377-91 Y Yang et al 2006 Investigation of optical coherence tomography as an imaging modality in tissue engineering Phys. Med. Biol. 51 1649-59 M Krämer and M Scholz 2006 Rapid calculation of biological effects in ion radiotherapy Phys. Med. Biol. 51 1959-70 P Crespo et al 2006 On the detector arrangement for in-beam PET for hadron therapy monitoring Phys. Med. Biol. 51 2143-63 R J Senden et al 2006 Polymer gel dosimeters with reduced toxicity: a preliminary investigation of the NMR and optical dose-response using different monomers Phys. Med. Biol. 51 3301-14 J Wang et al 2006 FDTD calculation of whole-body average SAR in adult and child models for frequencies from 30 MHz to 3 GHz Phys. Med. Biol. 51 4119-27 C A T Van den Berg et al 2006 The use of MR B+1 imaging for validation of FDTD electromagnetic simulations of human anatomies Phys. Med. Biol. 51 4735-46 S Qin and K W Ferrara 2006 Acoustic response of compliable microvessels containing ultrasound contrast agents Phys. Med. Biol. 51 5065-88 R Kramer et al 2006 Skeletal dosimetry in the MAX06 and the FAX06 phantoms for external exposure to photons based on vertebral 3D-microCT images Phys. Med. Biol. 51 6265-89 R Leiderman et al 2006 Coupling between elastic strain and interstitial fluid flow: ramifications for poroelastic imaging Phys. Med. Biol. 51 6291-313 An IPEM college of jurors then assessed and rated these papers in order to choose a winner. We have much pleasure in advising readers that the 2006 Roberts Prize is awarded to: M Krämer and M Scholz 2006 Rapid calculation of biological effects in ion radiotherapy Phys. Med. Biol. 51 1959-70 2007 Prize for the Highest Cited Paper The annual prize for the most highly cited paper is awarded by the journal publishers (IOP Publishing) to the article published in PMB that has received the most citations1 in the previous 5 years (in this case for the period 2002 to 2006 inclusive). We have much pleasure in advising readers that the 2007 prize is awarded to: S S Vedam, P J Keall, V R Kini, H Mostafavi, H P Shukla and R Mohan 2003 Acquiring a four-dimensional computed tomography dataset using an external respiratory signal Phys. Med. Biol. 48 45-62 Simon Harris, Publisher Steve Webb, Editor-in-Chief 1 Figures taken from Thomson/ISI

Predictors of and Trends in High-Intensity End-of-Life Care Among Children With Cancer: A Population-Based Study Using Health Services Data.

PubMed

Kassam, Alisha; Sutradhar, Rinku; Widger, Kimberley; Rapoport, Adam; Pole, Jason D; Nelson, Katherine; Wolfe, Joanne; Earle, Craig C; Gupta, Sumit

2017-01-10

Purpose Children with cancer often receive high-intensity (HI) medical care at the end-of-life (EOL). Previous studies have been limited to single centers or lacked detailed clinical data. We determined predictors of and trends in HI-EOL care by linking population-based clinical and health-services databases. Methods A retrospective decedent cohort of patients with childhood cancer who died between 2000 and 2012 in Ontario, Canada, was assembled using a provincial cancer registry and linked to population-based health-care data. Based on previous studies, the primary composite measure of HI-EOL care comprised any of the following: intravenous chemotherapy < 14 days from death; more than one emergency department visit; and more than one hospitalization or intensive care unit admission < 30 days from death. Secondary measures included those same individual measures and measures of the most invasive (MI) EOL care (eg, mechanical ventilation < 14 days from death). We determined predictors of outcomes with appropriate regression models. Sensitivity analysis was restricted to cases of cancer-related mortality, excluding treatment-related mortality (TRM) cases. Results The study included 815 patients; of these, 331 (40.6%) experienced HI-EOL care. Those with hematologic malignancies were at highest risk (odds ratio, 2.5; 95% CI, 1.8 to 3.6; P < .001). Patients with hematologic cancers and those who died after 2004 were more likely to experience the MI-EOL care (eg, intensive care unit, mechanical ventilation, odds ratios from 2.0 to 5.1). Excluding cases of TRM did not substantively change the results. Conclusion Ontario children with cancer continue to experience HI-EOL care. Patients with hematologic malignancies are at highest risk even when excluding TRM. Of concern, rates of the MI-EOL care have increased over time despite increased palliative care access. Linking health services and clinical data allows monitoring of population trends in EOL care and identifies high-risk populations for future interventions.

Seroprevalence of bovine viral diarrhea virus in crossbred dairy cattle in Bangladesh

PubMed Central

Uddin, Mohammed Arif; Ahasan, A. S. M. Lutful; Islam, Kamrul; Islam, Md. Zohorul; Mahmood, Altaf; Islam, Ariful; Islam, Kazi Muhammad Fakhrul; Ahad, Abdul

2017-01-01

Aim: The study was conducted to determine the seroprevalence of bovine viral diarrhea virus (BVDV) and hematological features in crossbred dairy cattle in Chittagong, Bangladesh. Materials and Methods: The antibody against BVDV in crossbred dairy cattle serum was detected by indirect enzyme-linked immunosorbent assay. The association of different categorical variables in the prevalence of BVDV has been studied. Blood samples were collected and analyzed to know the hematological variations in the study population. Results: The overall seroprevalence of BVDV in the study area was 51.1% (95% confidence interval [CI], 40.5-61.5). Among different physiological stages of animals, the highest 57.1% (95% CI, 42.2-71.2) prevalence was in case of non-pregnant animals. Aborted cows were found to be significantly (p<0.05) more seropositive 77.8% (95% CI, 52.4-93.6) than the non-aborted cows (77.8%, 95% CI, 52.4-93.6, compared to 44.7%, 95% CI, 33.3-56.6, respectively). Cows having the history of retained placenta were found more positive than without the history of retained placenta (63.2%, 95% CI, 38.4-83.7, compared to 54.7%, 95% CI, 40.4-68.4, respectively). Among the animals of different age groups, BVDV seroprevalence was higher 61.3% (95% CI, 42.2-78.2) in animals of more than 3 years up to 5 years, whereas 32% was in case of 0-1-year-old. Significant variation found in different geographical areas of the study area. Hematological analyses have shown variation between the BVDV positive and negative animals. Conclusion: Seroprevalence of BVDV found to be high in the study area is also economically important and cause significant damage to the production industry. Therefore, it is necessary to conduct effective control measures to reduce the burden of BVDV. PMID:28919681

Epigenetic Inactivation of Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 2 in Lung Cancer and Its Role in Tumorigenesis

PubMed Central

Hwang, Jung-Ah; Kim, Yujin; Hong, Seung-Hyun; Lee, Jieun; Cho, Yong Gu; Han, Ji-Youn; Kim, Young-Ho; Han, Joungho; Shim, Young Mog; Lee, Yeon-Su; Kim, Duk-Hwan

2013-01-01

Background This study was aimed at investigating the functional significance of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (HS3ST2) hypermethylation in non-small cell lung cancer (NSCLC). Methodology/ Principal Findings HS3ST2 hypermethylation was characterized in six lung cancer cell lines, and its clinical significance was analyzed using 298 formalin-fixed paraffin-embedded tissues and 26 fresh-frozen tissues from 324 NSCLC patients. MS-HRM (methylation-specific high-resolution melting) and EpiTYPERTM assays showed substantial hypermethylation of CpG island at the promoter region of HS3ST2 in six lung cancer cell lines. The silenced gene was demethylated and re-expressed by treatment with 5-aza-2′-deoxycytidine (5-Aza-dC). A promoter assay also showed the core promoter activity of HS3ST2 was regulated by methylation. Exogenous expression of HS3ST2 in lung cancer cells H460 and H23 inhibited cell migration, invasion, cell proliferation and whereas knockdown of HS3ST2 in NHBE cells induced cell migration, invasion, and cell proliferation in vitro. A negative correlation was observed between mRNA and methylation levels of HS3ST2 in 26 fresh-frozen tumors tissues (ρ = -0.51, P = 0.009; Spearman’s rank correlation). HS3ST2 hypermethylation was found in 95 (32%) of 298 primary NSCLCs. Patients with HS3ST2 hypermethylation in 193 node-negative stage I-II NSCLCs with a median follow-up period of 5.8 years had poor overall survival (hazard ratio = 2.12, 95% confidence interval = 1.25–3.58, P = 0.005) compared to those without HS3ST2 hypermethylation, after adjusting for age, sex, tumor size, adjuvant therapy, recurrence, and differentiation. Conclusions/ Significance The present study suggests that HS3ST2 hypermethylation may be an independent prognostic indicator for overall survival in node-negative stage I-II NSCLC. PMID:24265783

Nonspecific ST-T changes associated with unsatisfactory blood pressure control among adults with hypertension in China: Evidence from the CSPTT study.

PubMed

Bao, Huihui; Cai, Huaxiu; Zhao, Yan; Huang, Xiao; Fan, Fangfang; Zhang, Chunyan; Li, Juxiang; Chen, Jing; Hong, Kui; Li, Ping; Wu, Yanqing; Wu, Qinhua; Wang, Binyan; Xu, Xiping; Li, Yigang; Huo, Yong; Cheng, Xiaoshu

2017-03-01

Nonspecific ST-segment and T-wave (ST-T) changes represent one of the most prevalent electrocardiographic abnormalities in hypertensive patients. However, a limited number of studies have investigated the association between nonspecific ST-T changes and unsatisfactory blood pressure (BP) control in adults with hypertension.The study population comprised 15,038 hypertensive patients, who were selected from 20,702 participants in the China Stroke Primary Prevention Trial. The subjects were examined with electrocardiogram test at the initial visit in order to monitor baseline heart activity. According to the results of the electrocardiogram (defined by Minnesota coding), the subjects were divided into 2 groups: ST-T abnormal and ST-T normal. Unsatisfactory BP control was defined as systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg following antihypertensive treatment during the 4.5-year follow-up period. Multivariate analysis was used to analyze the association between nonspecific ST-T abnormalities and unsatisfactory BP control.Nonspecific ST-T changes were common in hypertensive adults (approximately 8.5% in the study), and more prevalent in women (10.3%) and diabetic patients (13.9%). The unsatisfactory BP control rate was high in the total population (47.0%), notably in the ST-T abnormal group (55.5%). The nonspecific ST-T abnormal group exhibited a significantly greater rate of unsatisfactory BP control (odds ratio [OR] 1.20, 95% confidence interval [CI] [1.06, 1.36], P = 0.005]), independent of traditional risk factors, as demonstrated by multivariate regression analysis. Notable differences were further observed in male subjects (OR 1.51, 95% CI [1.17, 1.94], P = 0.002) and in patients with comorbid diabetes (OR 1.47, 95% CI [1.04, 2.07], P = 0.029).Greater rates of unsatisfactory BP control in hypertensive patients with electrocardiographic nonspecific ST-T abnormalities were observed, notably in the subcategories of the male subjects and the diabetic patients.

Atmospheric CO2 Records from Sites in the Atmospheric Environment Service Air Sampling Network (1975 and 1994)

DOE Data Explorer

Trivett, N. B.A. [Atmospheric Environment Service, Downsview, Ontario, Canada; Hudec, V. C. [Atmospheric Environment Service, Downsview, Ontario, Canada; Wong, C. S. [Marine Carbon Research Centre, Institute of Ocean Sciences, Sidney, British Columbia, Canada

1997-01-01

From the mid-1970s through the mid-1990s, air samples were collected for the purposes of monitoring atmospheric CO2 from four sites in the AES air sampling network. Air samples were collected approximately once per week, between 12:00 and 16:00 local time, in a pair of evacuated 2-L thick-wall borosilicate glass flasks. Samples were collected under preferred conditions of wind speed and direction (i.e., upwind of the main station and when winds are strong and steady). The flasks were evacuated to pressures of ~1 × 10-4 mbar or 0.01 Pa prior to being sent to the stations. The airwas not dried during sample collection. The flask data from Alert show an increase in the annual atmospheric CO2 concentration from 341.35 parts per million by volume (ppmv) in 1981 to 357.21 ppmv in 1991. For Cape St. James, Trivett and Higuchi (1989) reported that the mean annual rate of increase, obtained from the slope of a least-squares regression line through the annual averages, was 1.43 ppmv per year. In August 1992, the weather station at Cape St. James was automated; as a result, the flask sampling program was discontinued at this site. Estevan Point, on the West Coast of Vancouver Island, was chosen as a replacement station. Sampling at Estevan Point started in 1992; thus, the monthly and annual CO2record from Estevan Point is too short to show any long-term trends. The sampling site at Sable Island, off the coast of Nova Scotia, was established in 1975. The flask data from Sable Island show an increase in the annual atmospheric CO2 concentration from 334.49 parts per million by volume (ppmv) in 1977 (the first full year of data) to 356.02 ppmv in 1990. For Sable Island, Trivett and Higuchi (1989) reported that the mean annual rate of increase, obtained from the slope of a least-squares regression line through the annual averages, was 1.48 ppmv per year.

Hematologic Profile and Semen Quality of Male Timor Deer (Rusa timorensis) at Various Hierarchies

NASA Astrophysics Data System (ADS)

Samsudewa, D.; Capitan, S. S.; Sevilla, C. C.; Vega, R. S. A.; Ocampo, P. P.

2018-02-01

The aim of this research was to observe hematologic profile i.e. erythrocyte count, hemoglobin and hematocrit and semen quality, i.e. semen volume, sperm motility and sperm abnormality of α-male, β-male and subordinate male Timor deer raised under captivity. Twelve males (51 ± 6 months old; 68.29 ± 8.41kg body weight) at similar antler stages were use in this study. Before and after 43 days of establishment of dominance hierarchy blood were sampled after sedation for erythrocyte count, hemoglobin (mg/dL), and hematocrit (%). Likewise, semen was collected using electroejaculator and were analyzed for semen volume (ml), sperm motility (%) and sperm abnormality (%) to compare male deer at various heirarchies. Wilcoxon signed ranks test and Kruskal-Wallis H test of non-parametric analysis was done. Significant difference was tested with Mann-Whitney U test. The results showed that highest count of erythrocyte shown on α and β-male (1.60 million per µL). The highest increase in hematocrit was observed in β-male (5%) and then followed by S2-male (4%). S2-male had the highest increase in hemoglobin (0.13 g/dL). The highest increase in semen volume was observed in α -male (0.75 ml). Social stress affected negatively the sperm motility and abnormality (P<0.05). The highest decrease was observed in S2-male.

Tier One Performance Screen Initial Operational Test and Evaluation: 2013 Annual Report

DTIC Science & Technology

2017-07-01

Reasoning (AR), and Math Knowledge (MK) tests (AFQT = 2*VE + AR + MK). Applicants must meet a minimum AFQT score to be eligible to serve in the military...Information (EI) 168,402 52.03 9.06 16 84 249,034 50.10 8.90 15 84 General Science (GS) 168,403 51.71 8.38 19 76 249,035 50.46 8.23 20 76 Math ...160,637 51.72 8.44 19 76 7,766 51.52 7.04 23 75 Math Knowledge (MK) 160,637 53.65 6.96 24 73 7,766 49.78 5.71 27 73 Mechanical Comprehension (MC

Epigenetic Testing for Breast Cancer Risk Stratification

DTIC Science & Technology

2014-06-01

associated cancer. None of the genes met all of these criteria, PECI and GSTP1 fulfilled most so were advanced for further assessment. IRF7 and VCAN...included: PECI, IRF7, VCAN, GNE, PSAT1, HS3ST2, CCND2, WDR66, GSTP1 , APC, and RASF1A. Task 2: Establish epigenetic regulation of gene expression by...0.05 PSAT1 0.75 0 d0.14 – 0.51 HS3ST2 0.83 0.02 d0.14 - 0.38 CCND1 0.85 0.31 d0.33 - 0.66 WDR66 0.8 0.1 c0.89 GSTP1 0.77 0 c0.22 APC 0.85 0.16

76 FR 77125 - Safety Zone; Sausalito Yacht Club's Annual Lighted Boat Parade and Fireworks Display, Sausalito, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

..., pyrotechnics will be loaded onto a barge at Pier 50 near position 37[deg]46'28'' N, 122[deg]23'06'' W (NAD 83... position 37[deg]51'30.92'' N, 122[deg]28'27.97'' W (NAD 83). The temporary safety zone will extend 100 feet... Pier 50 to position 37[deg]51'30.92'' N, 122[deg]28'27.97'' W (NAD 83). The fireworks display is...

American Society of Pediatric Hematology/Oncology

MedlinePlus

... Learn More Explore career opportunities in pediatric hematology/oncology Visit the ASPHO Career Center. Learn More Join ... Privacy Policy » © The American Society of Pediatric Hematology/Oncology

Patterns of Cancer in Kurdistan - Results of Eight Years Cancer Registration in Sulaymaniyah Province-Kurdistan-Iraq.

PubMed

Khoshnaw, Najmaddin; Mohammed, Hazha A; Abdullah, Dana A

2015-01-01

Cancer has become a major health problem associated with high mortality worldwide, especially in developing countries. The aim of our study was to evaluate the incidence rates of different types of cancer in Sulaymaniyah from January-2006 to January-2014. The data were compared with those reported for other middle east countries. This retrospective study depended on data collected from Hiwa hospital cancer registry unit, death records and histopathology reports in all Sulaymaniyah teaching hospitals, using international classification of diseases. A total of 8,031 cases were registered during the eight year period, the annual incidence rate in all age groups rose from 38 to 61.7 cases/100,000 population/year, with averages over 50 in males and 50.7 in females. The male to female ratio in all age groups were 0.98, while in the pediatric age group it was 1.33. The hematological malignancies in all age groups accounted for 20% but in the pediatric group around half of all cancer cases. Pediatric cancers were occluding 7% of total cancers with rates of 10.3 in boys and 8.7 in girls. The commonest malignancies by primary site were leukemia, lymphoma, brain, kidney and bone. In males in all age groups they were lung, leukaemia, lymphoma, colorectal, prostate, bladder, brain, stomach, carcinoma of unknown primary (CUP) and skin, while in females they were breast, leukaemia, lymphoma, colorectal, ovary, lung, brain, CUP, and stomach. Most cancers were increased with increasing age except breast cancer where decrease was noted in older ages. High mortality rates were found with leukemia, lung, lymphoma, colorectal, breast and stomach cancers. We here found an increase in annual cancer incidence rates across the period of study, because of increase of cancer with age and higher rates of hematological malignancies. Our study is valuable for Kurdistan and Iraq because it provides more accurate data about the exact patterns of cancer and mortality in our region.

Detection of malignancy in body fluids: a comparison of the hematology and cytology laboratories.

PubMed

Jerz, Jaclyn L; Donohue, Rachel E; Mody, Rayomond R; Schwartz, Mary R; Mody, Dina R; Zieske, Arthur W

2014-05-01

Body fluids submitted to the hematology laboratory for cell counts may also be examined for the presence of malignancy. Previous studies evaluating the hematology laboratory's performance at detecting malignancy in body fluids have reached conflicting conclusions. To investigate the hematology laboratory's ability to detect malignancy in body fluids by comparison with cytology. Retrospective analysis of 414 body fluid samples during an 18-month period, with introduction of new quality assurance measures after the first 210 cases. If no concurrent cytology was ordered, results were compared with recent previous and/or subsequent cytologic, histologic, or flow cytometric diagnoses. Of the initial 210 cases, the hematology laboratory detected 3 of 13 malignancies diagnosed by concurrent cytology (23% sensitivity), with no false-positives (100% specificity). Malignancy was not identified on retrospective review of the hematology slides in the 10 discrepant cases. After the initial study, educational sessions on morphology for the medical technologists and a more thorough hematology-cytology correlation policy were implemented. The subsequent 204 hematology laboratory cases had increased sensitivity for the detection of malignancy (60%; 6 of 10). Definitive features of malignancy were seen in only one discrepant hematology laboratory slide on retrospective review. This case had not been flagged for hematopathologist review. None of the discrepancies before or after implementation of the additional quality assurance measures impacted patient care. Body fluid processing by the hematology laboratory is not optimized for the detection of malignancy. Concurrent cytologic examination is critical for the detection of malignancy, and needs to be considered as cost-saving measures are increasingly implemented.

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial.

PubMed

Fabris, Enrico; van 't Hof, Arnoud; Hamm, Christian W; Lapostolle, Frédéric; Lassen, Jens F; Goodman, Shaun G; Ten Berg, Jurriën M; Bolognese, Leonardo; Cequier, Angel; Chettibi, Mohamed; Hammett, Christopher J; Huber, Kurt; Janzon, Magnus; Merkely, Béla; Storey, Robert F; Zeymer, Uwe; Cantor, Warren J; Tsatsaris, Anne; Kerneis, Mathieu; Diallo, Abdourahmane; Vicaut, Eric; Montalescot, Gilles

2017-08-01

In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system. This study sought to evaluate predictors of complete ST-segment resolution after percutaneous coronary intervention in ST-elevation myocardial infarction patients enrolled in the ATLANTIC trial. ST-segment analysis was performed on electrocardiograms recorded at the time of inclusion (pre-hospital electrocardiogram), and one hour after percutaneous coronary intervention (post-percutaneous coronary intervention electrocardiogram) by an independent core laboratory. Complete ST-segment resolution was defined as ≥70% ST-segment resolution. Complete ST-segment resolution occurred post-percutaneous coronary intervention in 54.9% ( n=800/1456) of patients and predicted lower 30-day composite major adverse cardiovascular and cerebrovascular events (odds ratio 0.35, 95% confidence interval 0.19-0.65; p<0.01), definite stent thrombosis (odds ratio 0.18, 95% confidence interval 0.02-0.88; p=0.03), and total mortality (odds ratio 0.43, 95% confidence interval 0.19-0.97; p=0.04). In multivariate analysis, independent negative predictors of complete ST-segment resolution were the time from symptoms to pre-hospital electrocardiogram (odds ratio 0.91, 95% confidence interval 0.85-0.98; p<0.01) and diabetes mellitus (odds ratio 0.6, 95% confidence interval 0.44-0.83; p<0.01); pre-hospital ticagrelor treatment showed a favorable trend for complete ST-segment resolution (odds ratio 1.22, 95% confidence interval 0.99-1.51; p=0.06). This study confirmed that post-percutaneous coronary intervention complete ST-segment resolution is a valid surrogate marker for cardiovascular clinical outcomes. In the current era of ST-elevation myocardial infarction reperfusion, patients' delay and diabetes mellitus are independent predictors of poor reperfusion and need specific attention in the future.

The integrated value of sST2 and global longitudinal strain in the early stratification of patients with severe aortic valve stenosis: a translational imaging approach.

PubMed

Fabiani, Iacopo; Conte, Lorenzo; Pugliese, Nicola Riccardo; Calogero, Enrico; Barletta, Valentina; Di Stefano, Rossella; Santoni, Tatiana; Scatena, Cristian; Bortolotti, Uberto; Naccarato, Antonio Giuseppe; Petronio, Anna Sonia; Di Bello, Vitantonio

2017-12-01

Aortic valve stenosis (AVS) is associated with significant myocardial fibrosis (MF). Global longitudinal strain (GLS) is a sensible indicator of systolic dysfunction. ST2 is a member of the interleukin (IL)-1 receptor family and a modulator of hypertrophic and fibrotic responses. We aimed at assessing: (a) the association between adverse LV remodeling, LV functional parameters (including GLS) and sST2 level. (b) The association between MF (detected by endo-myocardial biopsy) and sST2 in patients with AVS undergoing surgical valve replacement. Twenty-two patients with severe AVS and preserved EF underwent aortic valve replacement. They performed laboratory analysis, including serum ST2 (sST2), echocardiography and inter-ventricular septum biopsy to assess MF (%). We included ten controls for comparison. Compared to controls, patients showed higher sST2 levels (p < 0.0001). sST2 showed correlation with Age (r = 0.58; p = 0.0004), E/e' average (r = 0.58; p = 0.0007), GLS (r = 0.61; p = 0.0002), LAVi (r = 0.51; p = 0.003), LVMi (r = 0.43; p = 0.01), sPAP (r = 0.36; p = 0.04) and SVi (r = -0.47; p < 0.005). No correlation was found between MF and sST2. At ROC analysis, a sST2 ≥ 284 ng/mL had the best accuracy to discriminate controls from patients with impaired GLS, i.e. GLS ≤ 17% (AUC 0.80; p = 0.003; sensitivity 95%; specificity 83%) and increased E/e' average (AUC 0.87; p = 0.0001; sensitivity 96%; specificity 74%). At multivariate regression analysis GLS resulted the only independent predictor of sST2 levels (R 2  = 0.35; p =  0.0004). Patients with severe AVS present elevated sST2 levels. LV GLS resulted the only independent predictor of sST2 levels.

Water limitations on forest carbon cycling and conifer traits along a steep climatic gradient in the Cascade Mountains, Oregon

NASA Astrophysics Data System (ADS)

Berner, L. T.; Law, B. E.

2015-11-01

Severe droughts occurred in the western United States during recent decades, and continued human greenhouse gas emissions are expected to exacerbate warming and drying in this region. We investigated the role of water availability in shaping forest carbon cycling and morphological traits in the eastern Cascade Mountains, Oregon, focusing on the transition from low-elevation, dry western juniper (Juniperus occidentalis) woodlands to higher-elevation, wetter ponderosa pine (Pinus ponderosa) and grand fir (Abies grandis) forests. We examined 12 sites in mature forests that spanned a 1300 mm yr-1 gradient in mean growing-year climate moisture index (CMIgy ), computed annually (1964 to 2013) as monthly precipitation minus reference evapotranspiration and summed October to September. Maximum leaf area, annual aboveground productivity, and aboveground live tree biomass increased with CMIgy (r2 = 0.67-0.88, P < 0.05), approximately 50-, 30-, and 10-fold along this drier to wetter gradient. Interannual fluctuations in CMI affected the annual radial growth of 91 % of juniper, 51 % of pine, and 12 % of fir individuals from 1964 to 2013. The magnitude of the site-average growth-CMI correlations decreased with increased CMIgy (r2 = 0.53, P < 0.05). All three species, particularly fir, experienced pronounced declines in radial growth from c. 1985 to 1994, coinciding with a period of sustained below-average CMIgy and extensive insect outbreak. Traits of stress-tolerant juniper included short stature, high wood density for cavitation resistance, and high investment in water transport relative to leaf area. Species occupying wetter areas invested more resources in height growth in response to competition for light relative to investment in hydraulic architecture. Consequently, maximum tree height, leaf area : sapwood area ratio, and stem wood density were all correlated with CMIgy . The tight coupling of forest carbon cycling and species traits with water availability suggests that warmer and drier conditions projected for the 21st century could have significant biogeochemical, ecological, and social consequences in the Pacific Northwest.

Water limitations on forest carbon cycling and conifer traits along a steep climatic gradient in the Cascade Mountains, Oregon

NASA Astrophysics Data System (ADS)

Berner, L. T.; Law, B. E.

2015-09-01

Severe droughts occurred in the western United States during recent decades and continued human greenhouse gas emissions are expected to exacerbate warming and drying in this region. We investigated the role of water availability in shaping forest carbon cycling and morphological traits in the eastern Cascade Mountains, Oregon, focusing on the transition from low-elevation, dry western juniper (Juniperus occidentalis) woodlands to higher-elevation, wetter ponderosa pine (Pinus ponderosa) and grand fir (Abies grandis) forests. We examined 12 sites in mature forests that spanned a 1300 mm yr-1 gradient in mean growing-year climate moisture index (CMIgy ), computed annually (1964 to 2013) as monthly precipitation minus reference evapotranspiration and summed October to September. Maximum leaf area, annual aboveground productivity, and aboveground live tree biomass increased with CMIgy (r2 = 0.58-0.85, P < 0.05), approximately 50-, 30-, and 10-fold along this drier to wetter gradient. Interannual fluctuations in CMI affected the annual radial growth of 91 % of juniper, 51 % of pine, and 12 % of fir from 1964 to 2013. The magnitude of the site-average growth-CMI correlations decreased with increased CMIgy (r2 = 0.65, P < 0.05). All three species, particularly fir, experienced pronounced declines in radial growth from ca. 1985 to 1994, coinciding with a period of sustained below-average CMIgy and extensive insect outbreak. Traits of stress-tolerant juniper included short stature, high wood density for cavitation resistance, and high investment in water transport relative to leaf area. Species occupying wetter areas invested more resources in height growth in response to competition for light relative to investment in hydraulic architecture. Correspondingly, maximum tree height, leaf area:sapwood area ratio, and stem wood density were all correlated with CMIgy . The tight coupling of forest carbon cycling and species traits with water availability suggests that warmer and drier conditions projected for the 21st century could have significant biogeochemical, ecological, and social consequences in the Pacific Northwest.

Hydrology, water quality, and phosphorus loading of Little St Germain Lake, Vilas County, Wisconsin

USGS Publications Warehouse

Robertson, Dale M.; Rose, William J.

2000-01-01

The lake was monitored in detail again during 1991-94 by the U.S. Geological Survey (USGS) as part of a cooperative study with the Lake District. This study demonstrated water-quality variation among the basins of Little St. Germain Lake and extensive areas of winter anoxia (absence of oxygen). Further in-depth studies were then conducted during 1994-2000 to define the extent of winter anoxia, refine the hydrologic and phosphorus budgets of the lake, quantify the effects of annual drawdowns, and provide information needed to develop a comprehensive lake-management plan. This report presents the results of the studies since 1991.

[Prediction on the changes of forest fire danger rating in Great Xing'an Mountain region of Northeast China in the 21st century under effects of climate change].

PubMed

Yang, Guang; Shu, Li-Fu; Di, Xue-Ying

2012-12-01

Based on the A2a and B2a climatic scenarios for both the baseline period (1961-1990) and the future scenario periods (2010-2039, 2040-2069, and 2070-2099) from the Hadley Centre's General Circulation, and by using Delta method, WGEN downscaling methods, and Canadian Forest Fire Danger Rating System, this paper classified the forest fire dangers in Great Xing' an Mountains region of Heilongjiang Province, Northeast China, predicted the changes of the forest fire danger rating in the period 2010-2099 relative to baseline period (1961-1990), and analyzed the uncertainty of the long-term prediction of forest fire danger rating. It was predicted that under the background of climate warming, the mean annual days of extremely high, very high, and medium forest dangers in study region in the 21st century all showed an increasing trend, while the mean annual days of high and low forest dangers were in adverse. Relative to the baseline period of 1961-1990, the mean annual days of extremely high and very high forest dangers in the 2040-2069 and 2070-2099 under the scenarios of SRES A2a and B2a would be increased by 43 and 36, and 62 and 61, respectively.

Identification of the dopamine autoreceptor in the guinea-pig retina as D2 receptor using novel subtype-selective antagonists

PubMed Central

Weber, Bernd; Schlicker, Eberhard; Sokoloff, Pierre; Stark, Holger

2001-01-01

Dopamine release in the retina is subject to modulation via autoreceptors, which belong to the D2 receptor family (encompassing the D2, D3 and D4 receptors). The aim of the present study was to determine the receptor subtype (D2 vs D3) involved in the inhibition of dopamine release in guinea-pig retinal discs, using established (haloperidol, (S)-nafadotride) and novel dopamine receptor antagonists (ST-148, ST-198). hD2L and hD3 receptors were expressed in CHO cells and the pKi values determined in binding studies with [125I]-iodosulpride were: haloperidol 9.22 vs 8.54; ST-148 7.85 vs 6.60; (S)-nafadotride 8.52 vs 9.51; ST-198 6.14 vs 7.92. The electrically evoked tritium overflow from retinal discs preincubated with [3H]-noradrenaline (which represents quasi-physiological dopamine release) was inhibited by the dopamine receptor agonists B-HT 920 (talipexole) and quinpirole (maximally by 82 and 71%; pEC50 5.80 and 5.83). The concentration-response curves of these agonists were shifted to the right by haloperidol (apparent pA2 8.69 and 8.23) and ST-148 (7.52 and 7.66). (S)-Nafadotride 0.01 μM and ST-198 0.32 μM did not affect the concentration-response curve of B-HT 920. The dopamine autoreceptor in the guinea-pig retina can be classified as a D2 receptor. ST-148 and ST-198 show an improved selectivity for D2 and D3 receptors when compared to haloperidol and (S)-nafadotride, respectively. PMID:11498509

Distribution and Molecular Characterization of Acinetobacter baumannii International Clone II Lineage in Japan.

PubMed

Matsui, Mari; Suzuki, Masato; Suzuki, Masahiro; Yatsuyanagi, Jun; Watahiki, Masanori; Hiraki, Yoichi; Kawano, Fumio; Tsutsui, Atsuko; Shibayama, Keigo; Suzuki, Satowa

2018-02-01

Multidrug-resistant (MDR) Acinetobacter spp. have been globally disseminated in association with the successful clonal lineage Acinetobacter baumannii international clone II (IC II). Because the prevalence of MDR Acinetobacter spp. in Japan remains very low, we characterized all Acinetobacter spp. ( n = 866) from 76 hospitals between October 2012 and March 2013 to describe the entire molecular epidemiology of Acinetobacter spp. The most prevalent species was A. baumannii ( n = 645; 74.5%), with A. baumannii IC II ( n = 245) accounting for 28.3% of the total. Meropenem-resistant isolates accounted for 2.0% ( n = 17) and carried IS Aba1-bla OXA-23-like ( n = 10), bla IMP ( n = 4), or IS Aba1-bla OXA-51-like ( n = 3). Multilocus sequence typing of 110 representative A. baumannii isolates revealed the considerable prevalence of domestic sequence types (STs). A. baumannii IC II isolates were divided into the domestic sequence type 469 (ST469) ( n = 18) and the globally disseminated STs ST208 ( n = 14) and ST219 ( n = 4). ST469 isolates were susceptible to more antimicrobial agents, while ST208 and ST219 overproduced the intrinsic AmpC β-lactamase. A. baumannii IC II and some A. baumannii non-IC II STs (e.g., ST149 and ST246) were associated with fluoroquinolone resistance. This study revealed that carbapenem-susceptible A. baumannii IC II was moderately disseminated in Japan. The low prevalence of acquired carbapenemase genes and presence of domestic STs could contribute to the low prevalence of MDR A. baumannii A similar epidemiology might have appeared before the global dissemination of MDR epidemic lineages. In addition, fluoroquinolone resistance associated with A. baumannii IC II may provide insight into the significance of A. baumannii epidemic clones. Copyright © 2018 American Society for Microbiology.

77 FR 11527 - Bluewater Gas Storage, LLC; Notice of Intent To Prepare an Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-51-000] Bluewater Gas Storage, LLC; Notice of Intent To Prepare an Environmental Assessment for the Proposed St. Clair River Crossing Replacement Project, Request for Comments on Environmental Issues, and Notice of Onsite Environmental Review The staff of the Federal...

Children's Perceptions of Intergroup and Intragroup Similarity and the Role of Social Experience

ERIC Educational Resources Information Center

McGlothlin, Heidi; Killen, Melanie

2005-01-01

Perceptions of intragroup and intergroup similarity were assessed in 1st grade (M=6.78 years, SD=.42) and 4th grade (M=9.79, SD=.51) boys and girls (N=382) who attended either ethnically homogeneous or ethnically heterogeneous schools. Children's evaluations of same-race and cross-race friendships were also assessed. European-American children…

2. (Photocopy of the first sheet of a threesheet set ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. (Photocopy of the first sheet of a three-sheet set entitled 'Kongensgade 45B-51') KING STREET (FRONT) ELEVATIONS OF KONGENSGADE 45B-46A (see 'Kongensgade 45B-46A,' HABS No. VI-31) AND KONGENSGADE 46B-47 (see 'Kongensgade 46B-47,' HABS No. VI-165) - King Street Area Study, King Street, Christiansted, St. Croix, VI

Enhancing Laos Students' Understanding of Nature of Science in Physics Learning about Atom for Peace

ERIC Educational Resources Information Center

Sengdala, Phoxay; Yuenyong, Chokchai

2014-01-01

This paper aimed to study of Grade 12 students' understanding of nature of science in learning about atom for peace through science technology and society (STS) approach. Participants were 51 Grade 12 who study in Thongphong high school Vientiane Capital City Lao PDR, 1st semester of 2012 academic year. This research regarded interpretive…

43 CFR 3903.51 - Minimum production and payments in lieu of production.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE MANAGEMENT...) Each lease must meet its minimum annual production amount of shale oil or make a payment in lieu of...

43 CFR 3903.51 - Minimum production and payments in lieu of production.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) OIL SHALE MANAGEMENT...) Each lease must meet its minimum annual production amount of shale oil or make a payment in lieu of...