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Sample records for hemoglobinuria receiving eculizumab

  1. Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature

    PubMed Central

    Patriquin, Christopher; Leber, Brian

    2015-01-01

    Key Clinical Message Paroxysmal nocturnal hemoglobinuria (PNH) results from reduced complement regulatory proteins on hematopoietic cells, predisposing patients to intravascular hemolysis, thrombophilia, and cytopenias. Women diagnosed in pregnancy can experience significant maternofetal complications. Trials of eculizumab in PNH excluded pregnant women. Here, we report the first Canadian patient taken through pregnancy on eculizumab. PMID:25767703

  2. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations.

    PubMed

    Al-Ani, Fatimah; Chin-Yee, Ian; Lazo-Langner, Alejandro

    2016-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disorder resulting from somatic mutation in the PIG-A gene leading to a deficiency of the membrane-anchoring molecule glycosylphosphatidylinositol. The lack of expression of two glycosylphosphatidylinositol-anchored proteins involved in the regulation of the complement system renders PNH erythrocytes susceptible to complement-mediated lysis. Clinical manifestations include thromboembolic disease, chronic kidney injury, pulmonary hypertension, smooth muscle dysfunction, and chronic hemolysis. Until recently, treatment was mainly supportive with most patients suffering from significant morbidity and shortened survival compared to age-matched controls. The development of eculizumab, a humanized monoclonal antibody directed against the terminal complement protein C5, has resulted in dramatic improvements of survival and reduction in complications. In this paper, we review some special considerations pertaining to the use of eculizumab for PNH. PMID:27536121

  3. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    PubMed Central

    Al-Ani, Fatimah; Chin-Yee, Ian; Lazo-Langner, Alejandro

    2016-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disorder resulting from somatic mutation in the PIG-A gene leading to a deficiency of the membrane-anchoring molecule glycosylphosphatidylinositol. The lack of expression of two glycosylphosphatidylinositol-anchored proteins involved in the regulation of the complement system renders PNH erythrocytes susceptible to complement-mediated lysis. Clinical manifestations include thromboembolic disease, chronic kidney injury, pulmonary hypertension, smooth muscle dysfunction, and chronic hemolysis. Until recently, treatment was mainly supportive with most patients suffering from significant morbidity and shortened survival compared to age-matched controls. The development of eculizumab, a humanized monoclonal antibody directed against the terminal complement protein C5, has resulted in dramatic improvements of survival and reduction in complications. In this paper, we review some special considerations pertaining to the use of eculizumab for PNH. PMID:27536121

  4. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab.

    PubMed

    Krishnan, Suresh K; Hill, Anita; Hillmen, Peter; Arnold, Louise M; Brooksbank, Gemma L; Wood, Alex; Scarsbrook, Andrew; Davies, Mervyn H; Kelly, Richard J

    2013-12-01

    Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which reduced the size of the spleen and improved his blood count to the point that blood transfusions were no longer necessary. Splenic embolization was chosen over splenectomy due to the potential postoperative complications of splenectomy, especially that of thrombosis.

  5. Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

    PubMed Central

    Rondelli, Tommaso; Risitano, Antonio M.; de Latour, Régis Peffault; Sica, Michela; Peruzzi, Benedetta; Ricci, Patrizia; Barcellini, Wilma; Iori, Anna Paola; Boschetti, Carla; Valle, Veronica; Frémeaux-Bacchi, Veronique; De Angioletti, Maria; Socie, Gerard; Luzzatto, Lucio; Notaro, Rosario

    2014-01-01

    Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions. In 72 patients with hemolytic paroxysmal nocturnal hemoglobinuria on eculizumab we tested the hypothesis that response may depend on genetic polymorphisms of complement-related genes. We found no correlation between the complement component C3 genotypes and the need for blood transfusions. On the other hand, we found a significant correlation with the HindIII polymorphism of a complement regulatory gene, the complement receptor 1 (CR1) gene. At this locus two co-dominant alleles are known, of which H (common) is associated with high expression, whereas L (rare) is associated with low expression of CR1 on red blood cells. Patients who still needed blood transfusion on eculizumab accounted for 18% of the H/H homozygotes, 33% of the H/L heterozygotes and 68% of the L/L homozygotes (P=0.016). Thus, patients with paroxysmal nocturnal hemoglobinuria who have the L/L genotype are seven times more likely to be sub-optimal responders to eculizumab. Both in vitro and in vivo we found that the CR1 HindIII genotype correlates with the abundance of paroxysmal nocturnal hemoglobinuria red cells that have bound C3, and with the kinetics of C3 binding. These results are consistent with the notion that by affecting C3 binding the CR1 genotype influences the response to eculizumab treatment, and this emerges as a novel example of pharmacogenetics. PMID:24038027

  6. Horse anti-thymocyte globulin and eculizumab as concomitant therapeutic approach in an aplastic paroxysmal nocturnal hemoglobinuria patient: go or no-go?

    PubMed

    Alashkar, Ferras; Dührsen, Ulrich; Röth, Alexander

    2016-10-01

    We present the case of a 64-yr-old female paroxysmal nocturnal hemoglobinuria (PNH) patient with subsequent transition to severe aplastic anemia in whom a concomitant successful immunosuppressive therapy (horse anti-thymocyte globulin (hATG) and cyclosporin A) in addition to an ongoing long-term treatment with the terminal complement inhibitor eculizumab was initiated. No reduced ATG efficacy or severe adverse events were observed in the presence of eculizumab. In addition, the possible reoccurrence of PNH symptoms (thromboembolic events and/or intravascular hemolysis) was prevented, while T-cell depletion was similar to non-eculizumab-treated patients with partial remission being evident by day 83.

  7. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    PubMed Central

    De-la-Iglesia, Silvia; Luzardo, Hugo; Lemes, Angelina; Torres, Melissa; Gómez-Casares, Maria Teresa; Cruz, Naylen; Molero, Teresa

    2016-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is associated with severe end-organ damage and a high risk of thrombosis. Budd-Chiari syndrome, which develops after thrombotic occlusion of major hepatic blood vessels, is relatively common in PNH and has been associated with increased mortality. We report the case of a 46-year-old male with PNH who presented with Budd-Chiari syndrome associated with portal cavernoma, portal hypertension and hypersplenism. In September 2010, the patient suffered gastrointestinal bleeding, hematuria, and elevated plasma lactate dehydrogenase; he started eculizumab therapy with a good response. In October 2012, he developed upper gastrointestinal variceal bleeding and a splenorenal shunt was placed. At the time of writing, the patient remains stable and eculizumab continues to be effective. There is limited data on the use of eculizumab for prevention of hemolysis and its consequences in PNH patients undergoing surgery. Our findings provide evidence for the efficacy and safety of eculizumab in this setting. PMID:27757214

  8. Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.

    PubMed

    Hallstensen, Randi Fykse; Bergseth, Grethe; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Tobias; Holt, Jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole-Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger; Mollnes, Tom Eirik

    2015-04-01

    Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether or not the complement activity in newborns from pregnant women who receive eculizumab is impaired. A novel eculizumab-C5 complex (E-C5) specific assay was developed and revealed that two newborns carried only 6-7% of the E-C5 detected in their eculizumab-treated PNH mothers. Serum from the pregnant women completely lacked terminal complement pathway activity, whereas the complement activity in the serum of the newborns was completely normal. Data from the pregnant women and their newborns were compared with that of healthy age-matched female controls and healthy newborns, as well as a non-treated pregnant woman with PNH and her newborn. These all showed normal complement activity without detectable E-C5 complexes. Furthermore, absence of eculizumab or E-C5 in the newborn could not be explained by lack of eculizumab binding to the neonatal Fc receptor (FcRn), as eculizumab bound strongly to the receptor in vitro. In conclusion, despite binding to FcRn neither eculizumab nor E-C5 accumulates in fetal plasma, and eculizumab treatment during pregnancy does not impair the complement function in the newborn.

  9. Hemoglobinuria test

    MedlinePlus

    ... Hemolytic uremic syndrome (HUS) Kidney infection Kidney tumor Malaria Paroxysmal nocturnal hemoglobinuria Paroxysmal cold hemoglobinuria Sickle cell ... nephritic syndrome Burns Hemolytic anemia Hemolytic-uremic syndrome Malaria Paroxysmal nocturnal hemoglobinuria (PNH) Pulmonary tuberculosis Renal cell ...

  10. Eculizumab Injection

    MedlinePlus

    ... which too many red blood cells are broken down in the body, so there are not enough healthy cells to bring oxygen to all parts of the body). Eculizumab injection is also used to treat atypical hemolytic uremic syndrome (aHUS; an inherited condition in which small blood ...

  11. [Rare case of a pregnancy in a woman with paroxysmal nocturnal hemoglobinuria. Case report].

    PubMed

    Horányi, Dániel; Várkonyi, Andrea; Nagy, Gyula Richárd; Bodó, Imre; Masszi, Tamás

    2016-06-01

    Paroxysmal nocturnal hemoglobinuria is a rare hematological disease. It is associated with increased maternal and fetal complications to such an extent that pregnancy has been considered relatively contraindicated in woman with paroxysmal nocturnal haemoglobinuria. Recently, eculizumab, a monoclonal antibody, has been shown to decrease complications during pregnancies. The highest risk is thromboembolic complication and, therefore, anticoagulant is a standard therapy during pregnancy. In the presented case, a 29-year-old woman with a 5-year history of paroxysmal nocturnal haemoglobinuria had a pregnancy. It was her first pregnancy and was complicated by a sinus thrombosis at the 11th gestational week. After the introduction of eculizumab treatment, the remaining period of pregnancy and delivery were uncomplicated. There are only a few cases in the literature about pregnancy in woman with paroxysmal nocturnal hemoglobinuria who are treated with eculizumab. This monoclonal antibody seems to be safe and it likely prevents many of the complications otherwise observed.

  12. Stratification of responders towards eculizumab using a structural epitope mapping strategy

    PubMed Central

    Volk, Anna-Luisa; Hu, Francis Jingxin; Berglund, Magnus M.; Nordling, Erik; Strömberg, Patrik; Uhlen, Mathias; Rockberg, Johan

    2016-01-01

    The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). As recently reported there is a need for a precise classification of eculizumab responsive patients to allow for a safe and cost-effective treatment. To allow for such stratification, knowledge of the precise binding site of the drug on its target is crucial. Using a structural epitope mapping strategy based on bacterial surface display, flow cytometric sorting and validation via haemolytic activity testing, we identified six residues essential for binding of eculizumab to C5. This epitope co-localizes with the contact area recently identified by crystallography and includes positions in C5 mutated in non-responders. The identified epitope also includes residue W917, which is unique for human C5 and explains the observed lack of cross-reactivity for eculizumab with other primates. We could demonstrate that Ornithodorus moubata complement inhibitor (OmCI), in contrast to eculizumab, maintained anti-haemolytic function for mutations in any of the six epitope residues, thus representing a possible alternative treatment for patients non-responsive to eculizumab. The method for stratification of patients described here allows for precision medicine and should be applicable to several other diseases and therapeutics. PMID:27509843

  13. Stratification of responders towards eculizumab using a structural epitope mapping strategy.

    PubMed

    Volk, Anna-Luisa; Hu, Francis Jingxin; Berglund, Magnus M; Nordling, Erik; Strömberg, Patrik; Uhlen, Mathias; Rockberg, Johan

    2016-01-01

    The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). As recently reported there is a need for a precise classification of eculizumab responsive patients to allow for a safe and cost-effective treatment. To allow for such stratification, knowledge of the precise binding site of the drug on its target is crucial. Using a structural epitope mapping strategy based on bacterial surface display, flow cytometric sorting and validation via haemolytic activity testing, we identified six residues essential for binding of eculizumab to C5. This epitope co-localizes with the contact area recently identified by crystallography and includes positions in C5 mutated in non-responders. The identified epitope also includes residue W917, which is unique for human C5 and explains the observed lack of cross-reactivity for eculizumab with other primates. We could demonstrate that Ornithodorus moubata complement inhibitor (OmCI), in contrast to eculizumab, maintained anti-haemolytic function for mutations in any of the six epitope residues, thus representing a possible alternative treatment for patients non-responsive to eculizumab. The method for stratification of patients described here allows for precision medicine and should be applicable to several other diseases and therapeutics. PMID:27509843

  14. Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria

    PubMed Central

    Sahin, Fahri; Ozkan, Melda Comert; Mete, Nihal Gokmen; Yilmaz, Mumtaz; Oruc, Nevin; Gurgun, Alev; Kayikcioglu, Meral; Guler, Ayse; Gokcay, Figen; Bilgir, Ferda; Ceylan, Cengiz; Bilgir, Oktay; Sari, Ismail Hakan; Saydam, Guray

    2015-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell (HSC) lines due to a somatic mutation of the phosphatidylinositol glycan anchor (PIG-A) gene located on Xp22.1. PNH incidence is 1.5-2 cases per million of the population per year. PNH can affect multiple systems in the body and requires multidisciplinary clinical management. Patients can manifest with severe pancytopenia, life-threatening thrombosis affecting the hepatic, abdominal, cerebral, and subdermal veins, and high requirements for blood transfusion due to haemolytic anemia. PNH can also be associated with bone marrow failure. Advances in diagnostic techniques and a targeted therapeutic approach for PNH have emerged in the last two decades. Eculizumab, a promising humanized monoclonal antibody against C5, is the first approved therapy for PNH. PMID:26171279

  15. Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia.

    PubMed

    DeZern, Amy E; Brodsky, Robert A

    2015-06-01

    Paroxysmal nocturnal hemoglobinuria is manifests with a chronic hemolytic anemia from uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. Clinical manifestations result from the lack of specific cell surface proteins, CD55 and CD59, on PNH cells. Complement inhibition by eculizumab leads to dramatic clinical improvement. While this therapeutic approach is effective, there is residual complement activity resulting from specific clinical scenarios as well as from upstream complement components that can account for suboptimal responses in some patients. Complement inhibition strategies are an area of active research.

  16. Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement

    PubMed Central

    Pape, Lars; Hartmann, Hans; Bange, Franz Christoph; Suerbaum, Sebastian; Bueltmann, Eva; Ahlenstiel-Grunow, Thurid

    2015-01-01

    Abstract In typical hemolytic uremic syndrome (HUS) approximately 25% of patients show central nervous system (CNS) involvement often leading to serious long-term disabilities. We used the C5-complement inhibitor Eculizumab as rescue therapy. From 2011 to 2014, 11 children (median age 22 months, range 11–175) with enterohemorrhagic Escherichia coli-positive HUS requiring dialysis who had seizures (11/11) and/or were in a stupor or coma (10/11) were treated with Eculizumab. Two patients enrolled on the Safety and Efficacy Study of Eculizumab in Shiga-Toxin Producing E coli Hemolytic-Uremic Syndrome (STEC-HUS) each received 6 doses of Eculizumab, 3 patients 2 doses, and 6 patients 1 dose. Laboratory diagnostics of blood samples and magnetic resonance imaging (MRI) were performed as per center practice. Data were analyzed retrospectively. Cranial MRI was abnormal in 8 of 10 patients with findings in the basal ganglia and/or white matter. A 2-year-old boy with severe cardiac involvement and status epilepticus needed repeated cardio-pulmonary resuscitation and extracorporeal membrane oxygenation. He died 8 days after start of Eculizumab treatment. Two patients with hemorrhagic colitis and repeated seizures required artificial ventilation for 6 and 16 days, respectively. At the time of discharge, 1 patient showed severe neurological impairment and 1 mild neurological impairment. The 8 surviving patients experienced no further seizures after the first dose of Eculizumab. Three patients showed mild neurological impairment at discharge, whilst the remaining 5 showed no impairment. The platelets normalized 4 days (median) after the first dose of Eculizumab (range 0–20 days). The mean duration of dialysis after the first dose of Eculizumab was 14.1 ± 6.1 days. In children with typical HUS and CNS involvement early use of Eculizumab appears to improve neurological outcome. In severe HUS cases which progress rapidly with multiple organ involvement, late treatment with

  17. Disease Recurrence After Early Discontinuation of Eculizumab in a Patient With Atypical Hemolytic Uremic Syndrome With Complement C3 I1157T Mutation.

    PubMed

    Toyoda, Hidemi; Wada, Hideo; Miyata, Toshiyuki; Amano, Keishiro; Kihira, Kentaro; Iwamoto, Shotaro; Hirayama, Masahiro; Komada, Yoshihiro

    2016-04-01

    Eculizumab, terminal complement inhibitor, has become the frontline treatment for atypical hemolytic uremic syndrome (aHUS). However, the optimal treatment schedule has not yet been established. We describe here an aHUS patient with a mutation of C3 I1157T who achieved remission with eculizumab and suffered a recurrence after eculizumab discontinuation, a clinical situation that has not been previously described in patients with C3 mutation. A 9-year-old male experienced an onset of aHUS after viral gastroenteritis and was treated with hemodialysis. At 13 years of age he developed bacterial enterocolitis due to Campylobacter jejuni and experienced a recurrence of aHUS. Eculizumab was initiated on day 4 after disease onset resulting in recovering laboratory parameters. The patient received eculizumab for 5 months before its discontinuation. Second relapse induced by bacterial pharyngitis was confirmed 4 months after eculizumab discontinuation and prompt eculizumab reinitiation resulted in rapid remission. The patients carrying mutations in CFH or C3 have a high frequency of relapse and worse prognosis. More than 50% of aHUS relapses occurred during the first year after the onset. Therefore, long-term treatment with eculizumab is appropriate in patients with aHUS who have experienced a relapse or have mutations associated with poor prognosis. PMID:26840081

  18. Cerebral Venous Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    PubMed Central

    Meppiel, Elodie; Crassard, Isabelle; de Latour, Régis Peffault; de Guibert, Sophie; Terriou, Louis; Chabriat, Hugues; Socié, Gérard; Bousser, Marie-Germaine

    2015-01-01

    Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells characterized by hemolytic anemia, marrow failure, and a high incidence of life-threatening venous thrombosis. Cerebral venous system is the second most frequent location of thrombosis after hepatic veins. However, data about PNH-related cerebral venous thrombosis (CVT) are very scarce because of the rarity of both the disorders. We report a French study about PNH patients with CVT. Patients were recruited retrospectively, from the Société Française d’Hématologie (SFH) registry of 465 patients with PNH; the Lariboisière registry of 399 patients with CVT; and a direct contact with 26 French Hematology Units. We review cases reported since 1938 in the English and French language literature. We then compared patients of our series with cases from the literature, with non-PNH-related CVT cases from Lariboisière registry, and with PNH patients without CVT from SFH registry. Fifteen patients were included between 1990 and 2012. Most patients were women (12/15) and half of them presented associated hormonal venous thrombosis risk factors. Three patients had concomitant hepatic vein thrombosis. CVT was the first manifestation of PNH in 4 patients. No major difference in CVT characteristics was found compared with non-PNH-related CVT cases, except for a younger age at diagnosis in PNH patients (P < 0.001). All patients were treated with anticoagulation therapy. One death occurred in acute stage. All surviving patients were independent 1 year after. Median survival time was 9 years. Recurrent thrombosis rate was 50% at 6 years, occurring in patients that did not have bone marrow transplantation or eculizumab therapy. Cases of death were mainly related to hepatic vein thrombosis. Prognosis of CVT was good in our series. However, these patients have a poor long-term prognosis due to PNH disease by itself. PNH treatment should be proposed as soon as possible to

  19. Eculizumab and Recurrent C3 Glomerulonephritis

    PubMed Central

    Gurkan, Sevgi; Fyfe, Billie; Weiss, Lynne; Xiao, Xue; Zhang, Yuzhou; Smith, Richard J.

    2015-01-01

    Background and objectives Hyperactivity of the alternative complement pathway is the principle defect in the C3 glomerulopathies (C3G). Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, has been shown to be beneficial in some patients with this disease. Design, setting, participants & measurements In this open-label, proof-of-concept efficacy-and-safety study, a patient with the initial diagnosis of Dense Deposit Disease (DDD) and allograft recurrence of C3 (C3GN) glomerulonephritis was treated with eculizumab every-other-week for 1 year. The patient had pathological evidence of C3GN and proteinuria >1 g/d at enrollment. He underwent graft biopsy before enrollment and repeat biopsy at 6 months and 12 months. Results Although no mutations were identified in complement genes, functional studies were positive for C3 nephritic factors and elevated levels of soluble membrane attack complex (sMAC). On therapy, sMAC levels normalized and although proteinuria initially decreased, during therapy it increased reaching pre-treatment levels at 12 months. Although serum creatinine remained stable, repeat allograft biopsies showed progression of disease. Conclusions Clinical and histopathologic data suggest a partial response to eculizumab in this patient. While eculizumab blocked activation of the terminal complement cascade, persistent dysregulation of alternative pathway remained, showing that eculizumab alone cannot control disease in this patient. Additional research is required to identify effective anticomplement therapy for this group of C3G patients. PMID:23689905

  20. [Paroxysmal nocturnal hemoglobinuria: An unknown cause of thrombosis?].

    PubMed

    Doutrelon, C; Skopinski, S; Boulon, C; Constans, J; Viallard, J-F; Peffault de Latour, R

    2015-12-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells. Somatic mutation in the phosphatidylinositol glycan class A (PIG-A), X-linked gene, is responsible for a deficiency in glycosphosphatidylinositol-anchored proteins (GPI-AP). The lack of one of the GPI-AP complement regulatory proteins (CD55, CD59) leads to hemolysis. The disease is diagnosed with hemolytic anemia, marrow failure and thrombosis. Thromboembolic complication occurs in 30% of patient after 10 years of follow-up and is the first event in one out of 10 patients. The two most common sites are hepatic and cerebral veins. These locations are correlated with high risk of death. Currently, these data are balanced with the use of a monoclonal antibody (Eculizumab), which has significantly improved the prognosis with a survival similar to general population after 36 months of follow-up. Anticoagulant treatment is recommended after a thromboembolic event but has no place in primary prophylaxis. PMID:26205796

  1. Timing of eculizumab therapy for C3 glomerulonephritis

    PubMed Central

    Rodriguez-Osorio, Laura; Ortiz, Alberto

    2015-01-01

    Eculizumab is an anti-C5 antibody that inhibits C5 cleavage and prevents the generation of the terminal complement complex C5b-9. Eculizumab is licensed to treat paroxysmal nocturnal haemoglobinuria or atypical haemolytic uraemic syndrome (aHUS). Clinical trials are ongoing for C3 glomerulopathy. Given the unfamiliarity of physicians with these rare diseases and the variability of clinical presentation, a delayed initiation of eculizumab therapy is common. Thus, the question arises as to what extent improvement of kidney function may be expected when patients have been dialysis dependent for weeks or months already when eculizumab is initiated. Furthermore, given the high cost and potential adverse effects of eculizumab, the question arises of when to stop therapy because of futility when patients with kidney-only manifestations remain dialysis dependent. In literature reports, eculizumab was stopped as early as after 3 weeks because the patient remained dialysis dependent. In this issue of CKJ, Inman et al. report on eculizumab-induced reversal of dialysis-dependent kidney failure from C3 glomerulonephritis, illustrating both the potential benefit of eculizumab for this complement-mediated disease and the need for lengthy therapy—dialysis independency was reached after 5 months of eculizumab. Indeed, there are reports of renal function recovery when eculizumab was initiated after 4 months on dialysis and of recovery of renal function 2.0–3.5 months after initiation of eculizumab in dialysis-dependent patients with C3 glomerulopathy or aHUS. PMID:26251715

  2. Paroxysmal nocturnal hemoglobinuria: a single Spanish center’s experience over the last 40 yr

    PubMed Central

    Muñoz-Linares, Cristina; Ojeda, Emilio; Forés, Rafael; Pastrana, Miguel; Cabero, Martín; Morillo, Daniel; Bautista, Guiomar; Baños, Isolina; Monteserín, Carmen; Bravo, Pilar; Jaro, Esther; Cedena, Teresa; Steegmann, Juan Luis; Villegas, Ana; Cabrera, José Rafael

    2014-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease. To date, many reviews and series have been described. We report the experience of our center by presenting a review of 56 PNH patient cases with an average age at diagnosis of 38 yr and follow-ups beginning at approximately 40 yr; the median survival rate was 11 yr. The average clonal size upon diagnosis was 48%, presenting a variable evolution. Thrombotic episodes and cancer were five each, and the main causes of death among our patients were equal at 8.9%. Radiological study by magnetic resonance imaging is presented as a fundamental technique for estimating the deposit of iron levels in the liver and kidney, as well as in some decisive cases at the start of eculizumab therapy. Sixteen patients have been treated with eculizumab so far in our series, and being a safe drug, it provides improvement in the patients’ quality of life, and the disappearance of clinical symptoms, and avoids the emergence of new thrombosis. PMID:24758317

  3. Early treatment with eculizumab in atypical haemolytic uraemic syndrome.

    PubMed

    Garjau, Maria; Azancot, María; Ramos, Rosa; Sánchez-Corral, Pilar; Montero, Maria Angeles; Serón, Daniel

    2012-02-01

    Atypical haemolytic uraemic syndrome (aHUS) is a rare and life-threatening disease caused by complement system dysregulation leading to uncontrolled complement activation and thrombotic microangiopathy. We report the case of an adult patient with plasmaphaeresis-resistant aHUS and hypertension treated with the complement inhibitor eculizumab. Eculizumab was shown to completely inhibit haemolysis, normalize thrombocyte levels and increase diuresis. Full recovery of renal function was not possible due to irreversible renal damage prior to eculizumab initiation. These findings highlight the importance of early treatment with eculizumab in patients with poor response to standard therapy, in order to avoid irreversible renal damage.

  4. Early treatment with eculizumab in atypical haemolytic uraemic syndrome

    PubMed Central

    Garjau, Maria; Azancot, María; Sánchez-Corral, Pilar; Montero, Maria Angeles; Serón, Daniel

    2012-01-01

    Atypical haemolytic uraemic syndrome (aHUS) is a rare and life-threatening disease caused by complement system dysregulation leading to uncontrolled complement activation and thrombotic microangiopathy. We report the case of an adult patient with plasmaphaeresis-resistant aHUS and hypertension treated with the complement inhibitor eculizumab. Eculizumab was shown to completely inhibit haemolysis, normalize thrombocyte levels and increase diuresis. Full recovery of renal function was not possible due to irreversible renal damage prior to eculizumab initiation. These findings highlight the importance of early treatment with eculizumab in patients with poor response to standard therapy, in order to avoid irreversible renal damage. PMID:26069743

  5. Eculizumab for the Treatment of Severe Antibody-Mediated Rejection: A Case Report and Review of the Literature

    PubMed Central

    Boucher, Anne; Collette, Suzon; Senécal, Lynne

    2016-01-01

    In renal transplantation, treatment options for antibody-mediated rejection are limited. Here, we report a case of severe AMR treated with eculizumab. A 50-year-old woman known for end stage kidney disease secondary to IgA nephropathy received a kidney transplant from a 50-year-old deceased donor. At 5 months after transplantation, she presented with acute graft dysfunction and biopsy showed a severe antibody-mediated rejection associated with thrombotic microangiopathy. Despite an aggressive conventional immunosuppressive regimen, signs of rejection persisted and the patient was treated with 3 doses of eculizumab. Following the therapy, markers of TMA improved and graft function stabilized. However, ongoing signs of rejection remained in the repeated biopsy. In kidney transplantation, eculizumab is an expensive treatment and its role in the treatment of antibody-mediated rejection remains to be determined. PMID:27478676

  6. Compatible Transfusion Therapy for Paroxysmal Cold Hemoglobinuria

    ERIC Educational Resources Information Center

    Rausen, Aaron R.; And Others

    1975-01-01

    Presented are case histories of two children, ages 2 and 4 years, with paroxysmal cold hemoglobinuria (PCH, a syndrome characterized by acute intravascular hemoglobin dissolution and hemoglobin in the urine). (Author/CL)

  7. Can eculizumab be discontinued in aHUS?

    PubMed Central

    Sahutoglu, Tuncay; Basturk, Taner; Sakaci, Tamer; Koc, Yener; Ahbap, Elbis; Sevinc, Mustafa; Kara, Ekrem; Akgol, Cuneyt; Caglayan, Feyza Bayraktar; Unsal, Abdulkadir; Daha, Mohamed R.

    2016-01-01

    Abstract Background: The management of atypical hemolytic uremic syndrome (aHUS) has evolved into better control of thrombotic microangiopathy (TMA) and recovery of renal functions since the recent introduction of the terminal complement cascade blocker, eculizumab, into clinical use. Better characterization of genotype–phenotype relations has become possible with genetic and clinical studies. However, these advances brought up some important issues, such as the possibility and timing of discontinuation of eculizumab and strategy of follow-up that need to be enlightened. Case Summary: One of our aHUS cases with a novel complement factor H mutation, who developed unusual laboratory findings (thrombocytopenia and mild creatinine elevation without other features of TMA) following discontinuation of eculizumab was presented. Literature and case reports relevant to discontinuation of eculizumab in aHUS patients were reviewed. Conclusion: Limited experience suggests that the risk of recurrence of TMA following discontinuation of eculizumab is relatively low for patients with MCP mutations, homozygous CFHR3/R1 deletions, anti-CFH antibodies, CFI mutations, and no identifiable mutations, whereas there is a major risk for patients with CFH mutations. Early detection of TMA recurrence and prompt retreatment with eculizumab seem to be efficient in controlling of TMA and restoration of kidney functions. PMID:27495036

  8. [THE METHODICAL APPROACHES TO DIAGNOSTIC OF NIGHT PAROXYSMAL HEMOGLOBINURIA].

    PubMed

    Plekhanova, O S; Naumova, E V; Lugovskaya, S A; Potchtar, M E; Bugrov, I Yu; Dolgov, V V

    2016-03-01

    The article presents diagnostic of night paroxysmal hemoglobinuria. The night paroxysmal hemoglobinuria is an orphan disease characterized by absence of GPI-anchor on blood cells as a result of mutation of PIG-A gene on the short arm of X-chromosome. The particular proteins bounded with GPI-anchor implement function of defense from activation of components of complement and development of membrane-attacking complex. The erythrocytes exposed to destruction in bloodstream are among the most impacted. Therefore, one of the main signs of night paroxysmal hemoglobinuria is complement-depending intravascular hemolysis which indicators for a long time played a key role in diagnostic of night paroxysmal hemoglobinuria. The actual technique of diagnostic of night paroxysmal hemoglobinuria is flow cytometry. The analysis of night paroxysmal hemoglobinuria clone is recommended to patients with hemolysis of unclear genesis, thrombosis of cerebral and abdominal veins, thrombocytopenia and macrocytosis and also patients with AA, myelodysplastic syndrome, myelofibrosis. The international protocol recommended by the International Society of Clinical Cytometry (2010) is implemented to diagnose night paroxysmal hemoglobinuria. The original technique of evaluation of reticulocytes was developed with purpose to detect night paroxysmal hemoglobinuria clone. The high correlation was substantiated between size of night paroxysmal hemoglobinuria clone measured among reticulocytes according to proposed mode and night paroxysmal hemoglobinuria clone measured among granulocytes and monocytes detected according international standardized approach. PMID:27506106

  9. [THE METHODICAL APPROACHES TO DIAGNOSTIC OF NIGHT PAROXYSMAL HEMOGLOBINURIA].

    PubMed

    Plekhanova, O S; Naumova, E V; Lugovskaya, S A; Potchtar, M E; Bugrov, I Yu; Dolgov, V V

    2016-03-01

    The article presents diagnostic of night paroxysmal hemoglobinuria. The night paroxysmal hemoglobinuria is an orphan disease characterized by absence of GPI-anchor on blood cells as a result of mutation of PIG-A gene on the short arm of X-chromosome. The particular proteins bounded with GPI-anchor implement function of defense from activation of components of complement and development of membrane-attacking complex. The erythrocytes exposed to destruction in bloodstream are among the most impacted. Therefore, one of the main signs of night paroxysmal hemoglobinuria is complement-depending intravascular hemolysis which indicators for a long time played a key role in diagnostic of night paroxysmal hemoglobinuria. The actual technique of diagnostic of night paroxysmal hemoglobinuria is flow cytometry. The analysis of night paroxysmal hemoglobinuria clone is recommended to patients with hemolysis of unclear genesis, thrombosis of cerebral and abdominal veins, thrombocytopenia and macrocytosis and also patients with AA, myelodysplastic syndrome, myelofibrosis. The international protocol recommended by the International Society of Clinical Cytometry (2010) is implemented to diagnose night paroxysmal hemoglobinuria. The original technique of evaluation of reticulocytes was developed with purpose to detect night paroxysmal hemoglobinuria clone. The high correlation was substantiated between size of night paroxysmal hemoglobinuria clone measured among reticulocytes according to proposed mode and night paroxysmal hemoglobinuria clone measured among granulocytes and monocytes detected according international standardized approach.

  10. Hemoglobinuria Misidentified as Hematuria: Review of Discolored Urine and Paroxysmal Nocturnal Hemoglobinuria

    PubMed Central

    Veerreddy, Prashant

    2013-01-01

    Discolored urine is a common reason for office visits to a primary care physician and urology referral. Early differentiation of the type or cause of discolored urine is necessary for accurate diagnosis and prompt management. Paroxysmal nocturnal hemoglobinuria is a clonal disorder caused by acquired somatic mutations in the PIG-A gene on the X- chromosome of hemopoietic stem cells and leads to deficiency of surface membrane anchor proteins. The deficiency of these proteins leads to an increased risk of hemolysis of erythrocytes and structural damage of platelets, resulting in a clinical syndrome characterized by complement-mediated intravascular hemolytic anemia, bone marrow failure, and venous thrombosis. Patients with this clinical syndrome present with paroxysms of hemolysis, causing hemoglobinuria manifesting as discolored urine. This can be easily confused with other common causes of discolored urine and result in extensive urologic work-up. Three commonly confused entities of discolored urine include hematuria, hemoglobinuria, and myoglobinuria. Specific characteristics in a dipstick test or urinalysis can guide differentiation of these three causes of discolored urine. This article begins with a case summary of a woman presenting with cranberry-colored urine and a final delayed diagnosis of paryxysmal nocturnal hemoglobinuria. Her hemoglobinuria was misdiagnosed as hematuria, leading to extensive urologic work-up. The article also gives an overview of the approach to diagnosing and treating discolored urine. PMID:25512715

  11. [Renal vein infarction, a complication of paroxysmal nocturnal hemoglobinuria].

    PubMed

    de Charry, Charlotte; de Charry, Félicité; Lemoigne, François; Lamboley, Jean-Laurent; Pasquet, Florian; Pavic, Michel

    2012-12-01

    Paroxysmal nocturnal hemoglobinuria (Marchiafava-Micheli disease) is a rare acquired clonal disorder of the hematopoietic cell, to a somatic mutation in the phosphatidylinositol glycan (PIG-A). The most frequent clinical manifestations are hemolytic crisis and venous thrombosis of the mesenteric, hepatic, portal or cerebral territories. We report a case of paroxysmal nocturnal hemoglobinuria with renal vein thrombosis, a rare complication of this disease.

  12. Eculizumab for the treatment of preeclampsia/HELLP syndrome.

    PubMed

    Burwick, R M; Feinberg, B B

    2013-02-01

    Severe preeclampsia with hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is a leading cause of maternal and neonatal morbidity and mortality worldwide. Occurrence at an extremely premature gestational age is most challenging as there are dichotomous imperatives: delivery as definitive therapy for maternal health vs. prolongation of pregnancy to avoid prematurity and associated morbidities. We describe a patient presenting with severe preeclampsia/HELLP syndrome at 26 weeks gestation that was treated with Eculizumab, a targeted inhibitor of complement protein C5, which resulted in marked clinical improvement and complete normalization of lab parameters. Pregnancy was prolonged 17 days, likely resulting in a reduction of neonatal morbidity with its associated short and long-term health care costs. Successful use of Eculizumab in this case suggests that complement inhibition may be an effective treatment strategy for severe preeclampsia/HELLP syndrome. PMID:23228435

  13. Maintenance eculizumab dose adjustment in the treatment of atypical hemolytic uremic syndrome: a case report and review of the literature.

    PubMed

    Thomson, Nick; Ulrickson, Matthew

    2016-08-01

    Atypical hemolytic uremic syndrome (aHUS) patients treated with eculizumab may require higher doses to achieve and maintain optimal clinical response. Further studies are warranted to elucidate optimal dosing regimens of eculizumab in aHUS patients, and whether dosing regimens can be predicted based on mutational status, eculizumab levels, or other testing. PMID:27525082

  14. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

    PubMed

    Schmidt, Christoph Q; Harder, Markus J; Nichols, Eva-Maria; Hebecker, Mario; Anliker, Markus; Höchsmann, Britta; Simmet, Thomas; Csincsi, Ádám I; Uzonyi, Barbara; Pappworth, Isabel Y; Ricklin, Daniel; Lambris, John D; Schrezenmeier, Hubert; Józsi, Mihály; Marchbank, Kevin J

    2016-04-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators. Blockage of the lytic pathway by eculizumab is the only available therapy for PNH patients and shows remarkable benefits, but regularly yields PNH erythrocytes opsonized with fragments of complement protein C3, rendering such erythrocytes prone to extravascular hemolysis. This effect is associated with insufficient responsiveness seen in a subgroup of PNH patients. Novel C3-opsonin targeted complement inhibitors act earlier in the cascade, at the level of activated C3 and are engineered from parts of the natural complement regulator Factor H (FH) or complement receptor 2 (CR2). This inhibitor class comprises three variants of "miniFH" and the clinically developed "FH-CR2" fusion-protein (TT30). We show that the approach of FH-CR2 to target C3-opsonins was more efficient in preventing complement activation induced by foreign surfaces, whereas the miniFH variants were substantially more active in controlling complement on PNH erythrocytes. Subtle differences were noted in the ability of each version of miniFH to protect human PNH cells. Importantly, miniFH and FH-CR2 interfered only minimally with complement-mediated serum killing of bacteria when compared to untargeted inhibition of all complement pathways by eculizumab. Thus, the molecular design of each C3-opsonin targeted complement inhibitor determines its potency in respect to the nature of the activator/surface providing potential functionality in PNH. PMID:26792457

  15. Eculizumab Treatment in a Patient with Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy and Steroid-Refractory Acute Graft Versus Host Disease.

    PubMed

    Fernández, Cristina; Lario, Ana; Forés, Rafael; Cabrera, Rafael

    2015-11-23

    A 30-year-old man with acquired aplastic anemia underwent an HLA-identical bone marrow transplant. He developed a grade III acute graft versus host disease (GVHD) refractory to various lines of treatment. On post-transplant day 196, he was diagnosed with stem cell transplantation-associated thrombotic micro-angiopathy (HSCT-TMA) and he received treatment with eculizumab 900 mg iv weekly for 4 doses followed by a single dose of 1200 mg 2 weeks later. After the first dose of eculizumab, the patient ceased to require transfusions and a progressive improvement in analytical parameters for microangiopathy was observed until their complete normalization. Coinciding with the improved of HSCT-TMA, the patient presented a clear response to his acute GVHD with disappearance of the diarrhea and bilirubin normalization. He was discharged eight weeks after the start of treatment. Unfortunately, one month later, the patient was readmitted for a GVHD relapse and he died two weeks later by an acute respiratory distress syndrome. In our case, the rapid clinical and analytical response to early treatment with eculizumab supports the implication of the complement in HSCT-TMA and suggests that the drug has a beneficial effect when used as coadjuvant therapy in acute GVHD.

  16. Critical appraisal of eculizumab for atypical hemolytic uremic syndrome

    PubMed Central

    Palma, Lilian M Pereira; Langman, Craig B

    2016-01-01

    The biology of atypical hemolytic uremic syndrome has been shown to involve inability to limit activation of the alternative complement pathway, with subsequent damage to systemic endothelial beds and the vasculature, resulting in the prototypic findings of a thrombotic microangiopathy. Central to this process is the formation of the terminal membrane attack complex C5b-9. Recently, application of a monoclonal antibody that specifically binds to C5, eculizumab, became available to treat patients with atypical hemolytic uremic syndrome, replacing plasma exchange or infusion as primary therapy. This review focuses on the evidence, based on published clinical trials, case series, and case reports, on the efficacy and safety of this approach. PMID:27110144

  17. Thrombotic microangiopathy and human immunodeficiency virus in the era of eculizumab.

    PubMed

    Jin, Anna; Boroujerdi-Rad, Laleh; Shah, Gaurang; Chen, Joline L T

    2016-08-01

    Thrombotic microangiopathies (TMAs) include thrombotic thromobocytopenic purpura and hemolytic uremic syndrome (HUS). Among these conditions, atypical HUS is now recognized to be a disease of alternative complement pathway dysregulation. Eculizumab is a recombinant humanized monoclonal antibody that binds to the complement protein C5 and prevents the cleavage of C5 to C5a and C5b. Eculizumab has been used as a novel treatment for complement-mediated TMA. We present a case of a patient with human immunodeficiency virus infection who developed TMA and was successfully treated with eculizumab. The effect of long-term treatment with this new medication is unknown, and further studies are needed to establish guidelines in the management of this condition. PMID:27478600

  18. Eculizumab-induced reversal of dialysis-dependent kidney failure from C3 glomerulonephritis

    PubMed Central

    Inman, Melissa; Prater, Ginnie; Fatima, Huma; Wallace, Eric

    2015-01-01

    C3 glomerulopathy (C3G) is characterized by C3 deposits with minimal immunoglobulin deposition caused by alternative complement pathway dysregulation. Unfortunately, no therapeutic intervention has consistently improved outcomes for patients with C3G. Eculizumab, a monoclonal antibody to C5, is currently the only approved complement-specific agent with some efficacy in the treatment of C3 glomerulonephritis (C3GN). Here, we describe a patient with acute crescentic C3GN with no identified complement mutation or family history of renal disease who required dialysis for 6 months. Five months after initiation of eculizumab, she became dialysis independent, showing improvement is possible after adequate time on eculizumab. PMID:26251714

  19. Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome: a report of 10 cases.

    PubMed

    Ardissino, Gianluigi; Testa, Sara; Possenti, Ilaria; Tel, Francesca; Paglialonga, Fabio; Salardi, Stefania; Tedeschi, Silvana; Belingheri, Mirco; Cugno, Massimo

    2014-10-01

    Atypical hemolytic uremic syndrome (aHUS) is a life-threatening thrombotic microangiopathy, and as many as 70% of patients with aHUS have mutations in the genes encoding complement regulatory proteins. Eculizumab, a humanized recombinant monoclonal antibody targeting C5, has been used successfully in patients with aHUS since 2009. The standard maintenance treatment requires life-long eculizumab therapy, but the possibility of discontinuation has not yet been tested systematically. We report the safety of discontinuing eculizumab treatment in 10 patients who stopped treatment with the aim of minimizing the risk of adverse reactions, reducing the risk of meningitis, and improving quality of life while also reducing the considerable treatment costs. Disease activity was monitored closely at home by means of urine dipstick testing for hemoglobin. During the cumulative observation period of 95 months, 3 of the 10 patients experienced relapse within 6 weeks of discontinuation, but then immediately resumed treatment and completely recovered. Our experience supports the possibility of discontinuing eculizumab therapy with strict home monitoring for early signs of relapse in patients with aHUS who achieve stable remission. PMID:24656451

  20. Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients.

    PubMed

    Gaines, A R

    2000-04-15

    Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of action. Between licensure and April 1999, the FDA received 15 reports of hemoglobinemia and/or hemoglobinuria following anti-D IGIV administration that met the case definition for this review. The mechanism responsible for hemoglobinemia and/or hemoglobinuria is unexplained. Review of these reports was prompted by the seriousness and the unexpectedness of treatment-associated sequelae experienced by 11 patients. Of these patients, 7 developed sufficient onset or exacerbation of anemia that orders were written for packed red blood cell transfusions, although only 6 patients were transfused. Eight patients experienced the onset or exacerbation of renal insufficiency, and 2 patients underwent dialysis. One patient died due to complications of exacerbated anemia. Six patients experienced 2 to 3 sequelae. Absent validated incidence data, a 1.5% estimated incidence rate from published clinical trial data and a 0.1% estimated reporting rate from FDA and drug utilization data were calculated for reported cases of hemoglobinemia and/or hemoglobinuria. This review presents the first case series of anti-D-IGIV-associated hemoglobinemia and/or hemoglobinuria and provides pretreatment and posttreatment clinical and laboratory findings of the case series patients. The primary purpose of this review is to increase awareness of this potentially serious occurrence among physicians and health care professionals who manage ITP patients treated with anti-D IGIV, thereby enabling prompt recognition and treatment of sequelae. (Blood. 2000;95:2523-2529)

  1. Two case studies and a review of paroxysmal cold hemoglobinuria.

    PubMed

    Slemp, Stephanie N; Davisson, Suzanne M; Slayten, Jayanna; Cipkala, Douglas A; Waxman, Dan A

    2014-01-01

    Paroxysmal cold hemoglobinuria (PCH) is an acquired hemolytic anemia caused by immunoglobulin G (IgG) antibodies that sensitize red blood cells (RBCs) at cold temperatures by fixing complement to the RBCs causing intravascular hemolysis on rewarming. PCH usually appears in young children as recurrent high fevers, chills, and passage of red-brown urine. The diagnostic test for PCH is the Donath-Landsteiner test, an in vitro assay for biphasic hemolysis. Herein, we present 2 cases of PCH that occurred within 12 months of each other. We quickly diagnosed the second case and treated the patient successfully, in part due to our recognition of its characteristics based on the first case. PCH is a hemolytic anemia for which there is a specific diagnostic test; the timely recognition of this entity by physicians and laboratory staff will allow prompt, supportive therapy and will raise the odds of quick resolution of hemolysis. PMID:25051079

  2. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia.

    PubMed

    Narita, Atsushi; Muramatsu, Hideki; Sekiya, Yuko; Okuno, Yusuke; Sakaguchi, Hirotoshi; Nishio, Nobuhiro; Yoshida, Nao; Wang, Xinan; Xu, Yinyan; Kawashima, Nozomu; Doisaki, Sayoko; Hama, Asahito; Takahashi, Yoshiyuki; Kudo, Kazuko; Moritake, Hiroshi; Kobayashi, Masao; Kobayashi, Ryoji; Ito, Etsuro; Yabe, Hiromasa; Ohga, Shouichi; Ohara, Akira; Kojima, Seiji

    2015-12-01

    Acquired aplastic anemia is an immune-mediated disease characterized by severe defects in stem cell number resulting in hypocellular marrow and peripheral blood cytopenias. Minor paroxysmal nocturnal hemoglobinuria populations and a short telomere length were identified as predictive biomarkers of immunosuppressive therapy responsiveness in aplastic anemia. We enrolled 113 aplastic anemia patients (63 boys and 50 girls) in this study to evaluate their response to immunosuppressive therapy. The paroxysmal nocturnal hemoglobinuria populations and telomere length were detected by flow cytometry. Forty-seven patients (42%) carried a minor paroxysmal nocturnal hemoglobinuria population. The median telomere length of aplastic anemia patients was -0.99 standard deviation (SD) (range -4.01-+3.01 SD). Overall, 60 patients (53%) responded to immunosuppressive therapy after six months. Multivariate logistic regression analysis identified the absence of a paroxysmal nocturnal hemoglobinuria population and a shorter telomere length as independent unfavorable predictors of immunosuppressive therapy response at six months. The cohort was stratified into a group of poor prognosis (paroxysmal nocturnal hemoglobinuria negative and shorter telomere length; 37 patients) and good prognosis (paroxysmal nocturnal hemoglobinuria positive and/or longer telomere length; 76 patients), respectively. The response rates of the poor prognosis and good prognosis groups at six months were 19% and 70%, respectively (P<0.001). The combined absence of a minor paroxysmal nocturnal hemoglobinuria population and a short telomere length is an efficient predictor of poor immunosuppressive therapy response, which should be considered while deciding treatment options: immunosuppressive therapy or first-line hematopoietic stem cell transplantation. The trial was registered in www.umin.ac.jp with number UMIN000017972.

  3. Successful Salvage Treatment of Resistant Acute Antibody-Mediated Kidney Transplant Rejection with Eculizumab.

    PubMed

    Khan, Saif A; Al-Riyami, Dawood; Al-Mula Abed, Yasser W; Mohammed, Saja; Al-Riyami, Marwa; Al-Lawati, Nabil M

    2016-08-01

    Antibody-mediated rejection (ABMR) jeopardises short- and long-term transplant survival and remains a challenge in the field of organ transplantation. We report the first use of the anticomplement agent eculizumab in Oman in the treatment of a 61-year-old female patient with ABMR following a living unrelated kidney transplant. The patient was admitted to the Sultan Qaboos University Hospital in Muscat, Oman, in 2013 on the eighth day post-transplantation with serum creatinine (Cr) levels of 400 µmol/L which continued to rise, necessitating haemodialysis. A biopsy indicated ABMR with acute cellular rejection. No improvement was observed following standard ABMR treatment and she continued to require dialysis. Five doses of eculizumab were administered over six weeks with a subsequent dramatic improvement in renal function. The patient became dialysis-free with serum Cr levels of 119 µmol/L within four months. This case report indicates that eculizumab is a promising agent in the treatment of ABMR. PMID:27606122

  4. Successful Salvage Treatment of Resistant Acute Antibody-Mediated Kidney Transplant Rejection with Eculizumab

    PubMed Central

    Khan, Saif A.; Al-Riyami, Dawood; Al-Mula Abed, Yasser W.; Mohammed, Saja; Al-Riyami, Marwa; Al-Lawati, Nabil M.

    2016-01-01

    Antibody-mediated rejection (ABMR) jeopardises short- and long-term transplant survival and remains a challenge in the field of organ transplantation. We report the first use of the anticomplement agent eculizumab in Oman in the treatment of a 61-year-old female patient with ABMR following a living unrelated kidney transplant. The patient was admitted to the Sultan Qaboos University Hospital in Muscat, Oman, in 2013 on the eighth day post-transplantation with serum creatinine (Cr) levels of 400 µmol/L which continued to rise, necessitating haemodialysis. A biopsy indicated ABMR with acute cellular rejection. No improvement was observed following standard ABMR treatment and she continued to require dialysis. Five doses of eculizumab were administered over six weeks with a subsequent dramatic improvement in renal function. The patient became dialysis-free with serum Cr levels of 119 µmol/L within four months. This case report indicates that eculizumab is a promising agent in the treatment of ABMR.

  5. Successful Salvage Treatment of Resistant Acute Antibody-Mediated Kidney Transplant Rejection with Eculizumab

    PubMed Central

    Khan, Saif A.; Al-Riyami, Dawood; Al-Mula Abed, Yasser W.; Mohammed, Saja; Al-Riyami, Marwa; Al-Lawati, Nabil M.

    2016-01-01

    Antibody-mediated rejection (ABMR) jeopardises short- and long-term transplant survival and remains a challenge in the field of organ transplantation. We report the first use of the anticomplement agent eculizumab in Oman in the treatment of a 61-year-old female patient with ABMR following a living unrelated kidney transplant. The patient was admitted to the Sultan Qaboos University Hospital in Muscat, Oman, in 2013 on the eighth day post-transplantation with serum creatinine (Cr) levels of 400 µmol/L which continued to rise, necessitating haemodialysis. A biopsy indicated ABMR with acute cellular rejection. No improvement was observed following standard ABMR treatment and she continued to require dialysis. Five doses of eculizumab were administered over six weeks with a subsequent dramatic improvement in renal function. The patient became dialysis-free with serum Cr levels of 119 µmol/L within four months. This case report indicates that eculizumab is a promising agent in the treatment of ABMR. PMID:27606122

  6. Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

    PubMed Central

    Hillmen, Peter; Muus, Petra; Röth, Alexander; Elebute, Modupe O; Risitano, Antonio M; Schrezenmeier, Hubert; Szer, Jeffrey; Browne, Paul; Maciejewski, Jaroslaw P; Schubert, Jörg; Urbano-Ispizua, Alvaro; de Castro, Carlos; Socié, Gérard; Brodsky, Robert A

    2013-01-01

    Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by chronic, uncontrolled complement activation resulting in elevated intravascular haemolysis and morbidities, including fatigue, dyspnoea, abdominal pain, pulmonary hypertension, thrombotic events (TEs) and chronic kidney disease (CKD). The long-term safety and efficacy of eculizumab, a humanized monoclonal antibody that inhibits terminal complement activation, was investigated in 195 patients over 66 months. Four patient deaths were reported, all unrelated to treatment, resulting in a 3-year survival estimate of 97·6%. All patients showed a reduction in lactate dehydrogenase levels, which was sustained over the course of treatment (median reduction of 86·9% at 36 months), reflecting inhibition of chronic haemolysis. TEs decreased by 81·8%, with 96·4% of patients remaining free of TEs. Patients also showed a time-dependent improvement in renal function: 93·1% of patients exhibited improvement or stabilization in CKD score at 36 months. Transfusion independence increased by 90·0% from baseline, with the number of red blood cell units transfused decreasing by 54·7%. Eculizumab was well tolerated, with no evidence of cumulative toxicity and a decreasing occurrence of adverse events over time. Eculizumab has a substantial impact on the symptoms and complications of PNH and results a significant improvement in patient survival. PMID:23617322

  7. Posterior reversible encephalopathy syndrome following paroxysmal nocturnal hemoglobinuria: a case report and literature review.

    PubMed

    Ding, Dongxue; Li, Kai; Li, Guoliang; Long, Xiaoyan

    2015-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder characterized by hemolytic anemia, marrow failure, and a high incidence of life-threatening venous thrombosis. It is subject to a considerable variety of complications like intestinal obstruction and visceral embolism. The current study firstly presents a 40-year-old male with a previous diagnosis of PNH who developed posterior reversible encephalopathy syndrome (PRES) during treatment with methylprednisolone. He was referred to our department with headache and two episodes of generalized tonic-clonic seizures. Laboratory examination revealed peripheral blood cytopenias and elevated count of reticulocyte. Brain magnetic resonance imaging (MRI) exhibited abnormal signal in the bilateral parieto-occipital lobes with symmetric distribution which confirmed the diagnosis of PRES. After receive treatment of dexamethasone, anti-hypertensive and neurotropic drugs, the patient made a complete clinical recovery; and the abnormal signals of MRI were almost completely absorbed. This case shows that PRES might be a rare complication of PNH. Furthermore, it points out the necessity of rapid diagnosis and treatment of PRES. PMID:26379993

  8. Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.

    PubMed

    Gaines, Ann Reed

    2005-09-01

    The Food and Drug Administration (FDA) licensed Rh(o)(D) immune globulin intravenous (anti-D IGIV) on March 24, 1995, for treatment of immune thrombocytopenic purpura (ITP). A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia. Eleven of those patients also experienced clinically compromising anemia, transfusion with packed red blood cells, renal insufficiency, dialysis, or death. That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC). Through November 30, 2004, the FDA received 6 reports of DIC associated with "acute hemolysis" (or similar terms), 5 of which involved fatalities. The attending or consulting physicians assessed that acute hemolysis or DIC caused or contributed to each death. This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP. The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment. Increased awareness of DIC as a diagnostic possibility may enable prompt recognition and medical intervention in affected patients.

  9. Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab

    PubMed Central

    Greenwood, Gregory T

    2015-01-01

    Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by chronic, uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy. Renal impairment and progression to end-stage renal disease are common in untreated patients with aHUS, and extrarenal manifestations are being increasingly characterized in the literature. Ocular involvement remains rare in aHUS. This report describes a patient with aHUS with bilateral central retinal artery and vein occlusion, vitreous hemorrhage, and blindness in addition to renal impairment. The patient’s hematologic and renal parameters and ocular manifestation improved following initiation of eculizumab therapy. PMID:26508891

  10. Use of Eculizumab in Atypical Hemolytic Uremic Syndrome, Complicating Systemic Lupus Erythematosus.

    PubMed

    Bermea, Rene S; Sharma, Niharika; Cohen, Kenneth; Liarski, Vladimir M

    2016-09-01

    Atypical hemolytic uremic syndrome is characterized by the presence of thrombocytopenia, microangiopathic hemolytic anemia, and end-organ injury. In this report, we describe two patients with systemic lupus erythematosus who presented with findings compatible with atypical hemolytic uremic syndrome, complicated by acute kidney injury that was refractory to conventional therapies. Both patients exhibited a response to eculizumab, a monoclonal antibody to complement protein C5, with stabilization of their platelet count. On 1-year follow-up from their initial presentation, their hematologic disease remained in remission without recurrence. PMID:27556240

  11. Atypical Hemolytic Uremic Syndrome Secondary to Lupus Nephritis, Responsive to Eculizumab

    PubMed Central

    Raufi, Alexander G.; Scott, Shruti; Darwish, Omar; Harley, Kevin; Kahlon, Kanwarpal; Desai, Sheetal; Lu, Yuxin; Tran, Minh-Ha

    2016-01-01

    Among the spectrum of disease manifestations associated with systemic lupus erythematosus, lupus nephritis is particularly concerning due to the potential for renal failure. This autoimmune attack may not, however, be limited to the kidney and is increasingly being recognized as a trigger for atypical Hemolytic Uremic Syndrome (aHUS). Atypical HUS falls under the spectrum of the thrombotic microangiopathies (TMAs) – a group of disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end organ damage. Although plasma exchange is considered first-line therapy for thrombotic thrombocytopenic purpura – a TMA classically associated with autoimmune depletion of ADAMTS-13 – aHUS demonstrates less reliable responsiveness to this modality. Instead, use of the late complement inhibitor Eculizumab has emerged as an effective modality for the management of such patients. Diagnosis of aHUS, however, is largely clinically based, relying heavily upon a multidisciplinary approach. Herein we present the case of a patient with atypical HUS successfully treated with Eculizumab in the setting of Class IV-G (A) lupus nephritis and hypocomplementemia. PMID:27781079

  12. [Efficacy of eculizumab in a case of pregnancy-associated aHUS].

    PubMed

    Cravero, Raffaella; Ardissino, Gianluigi; Colageo, Umberto; Staffa, Piernicola; Bruschetta, Elena; Maroni, Serena; Karvela, Eirini; Spagarino, Ermanno; Ruggeri, Velia; Jura, Roberto

    2016-01-01

    Pregnancy-associated thrombotic microangiopathy (TMA) is a rare condition, but it is burdened by a significant perinatal and maternal morbidity as well as mortality. We describe the case of a 33-year-old woman, who developed a TMA at the 36th week of gestation characterized by increased LDH, haptoglobin consumption, schistocytes, thrombocytopenia and acute renal failure requiring dialysis. There were not gestational hypertension nor proteinuria until the day of hospitalization. ADAMTS 13 deficiency was ruled out and the patient did not have diarrhea. She was initially treated with caesarean section, plasma infusion and plasmapheresis with no benefit. Five days after the onset of TMA, a temptative diagnosis of atypical uremic syndrome (aHUS) was made and the patient was switched to eculizumab. Antibiotic prophylaxis and anti-meningococcal A,B, C, W135 and Y vaccination was performed. TMA rapidly resolved and renal function completely recovered. The newborn had a normal perinatal course. A complement dysregulation was ruled out by testing for mutations on CFH, CFHR3-R1, CFI, MCP, CFB, C3 and for anti CFH antibodies. In conclusion the differential diagnosis of aHUS with HELLP syndrome is often not straightforward. The severity and persistence of TMA, the high mortality associated to peripartum TMA and the risk for irreversible kidney failure require an early therapeutic decision as to the use of eculizumab. PMID:27545639

  13. [Autoimmune hemolytic anemia with a paroxysmal nocturnal hemoglobinuria-like defect: report of one case].

    PubMed

    Tong, Juxian; Kou, Wei; Chen, Qi; Xiao, Duan

    2013-12-01

    Both autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria are common hemolytic diseases. The former causes hemolysis because of immune disorder, and the latter is an acquired clonal hematologic disorder of stem cells. The two entities are often separate diseases, but can also occur concomitantly or secondary to each other. paroxysmal nocturnal haemoglobinuria-like defect-like defect is a special type of autoimmune haemolytic anaemia and should be distinguished from typical paroxysmal nocturnal haemoglobinuria-like defect.

  14. Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil

    PubMed Central

    de Brito Junior, Lacy Cardoso; Cardoso, Maria do Socorro de Oliveira; Rocha, Euzamar Gaby; Anijar, Herika; Cunha, Mariana; Saraiva, João Carlos Pina

    2011-01-01

    Background Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best known antigens are DAF (decay accelerating factor or CD55) and MIRL (membrane inhibitor of reactive lysis or CD59). Objective To determine the frequency of paroxysmal nocturnal hemoglobinuria in patients attended at the HEMOPA foundation from November 2008 to July 2009. Method Thirty patients, with ages ranging from two to 79 years old and suspected of having paroxysmal nocturnal hemoglobinuria were examined. All patients were immunophenotyped by flow cytometry for the CD5, CD59, CD16 and CD45 antigens. Results Paroxysmal nocturnal hemoglobinuria was identified in nine of the thirty patients investigated. Another 3 cases had inconclusive results with CD59-negative labeling only for neutrophils. The highest frequency of paroxysmal nocturnal hemoglobinuria patients (7/9) and inconclusive cases (2/3) were between 19 years old and 48 years old, with a median of 28 years. Conclusion These results show the importance of flow cytometry to identify cases in which patients are deficient in only one antigen (CD59). PMID:23284241

  15. BRODIFACOUM INDUCES EARLY HEMOGLOBINURIA AND LATE HEMATURIA IN RATS: NOVEL RAPID BIOMARKERS OF POISONING

    PubMed Central

    Ware, Kyle M; Feinstein, Douglas L; Rubinstein, Israel; Weinberg, Guy; Rovin, Brad H; Hebert, Lee; Muni, Navin; Cianciolo, Rachel E.; Satoskar, Anjali A; Nadasdy, Tibor; Brodsky, Sergey V

    2015-01-01

    Introduction Brodifacoum (BDF) is a superwarfarin that is used primarily as a rodenticide. There have been increasing number of reports of human cases of accidental or intentional BDF ingestion with high mortality rate. Its broad availability and high lethality suggest that BDF should be considered a potential chemical threat. Currently, there is no biomarker for early detection of BDF ingestion in humans; patients typically present with severe coagulopathy. Since we demonstrated earlier that warfarin can induce acute kidney injury with hematuria, we tested whether BDF would also lead to change in urinary biomarkers. Material and methods BDF was administered to Sprague Dawley rats via oral gavage. N-acetylcysteine (NAC) was given per os in drinking water 24 hours prior to BDF. Urinalysis was performed at different times after BDF administration. Anticoagulation and serum creatinine levels were analyzed in the blood. Results We observed that within a few hours the animals developed BDF-dose-dependent transient hemoglobinuria, which ceased within 24 hours. This was accompanied by a transient decrease in hematocrit, gross hemolysis and an increase in free hemoglobin in the serum. At later times, animals developed true hematuria with red blood cells in the urine, which was associated with BDF anticoagulation. NAC prevented early hemoglobinuria, but not late hematuria associated with BDF. Conclusions We propose that transient early hemoglobinuria (associated with oxidative stress) with consecutive late hematuria (associated with anticoagulation) are novel biomarkers of BDF poisoning and they can be used in clinical setting or in mass-casualty with BDF to identify poisoned patients. PMID:26111556

  16. Studies of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes: Increased Lysis and Lipid Peroxide Formation by Hydrogen Peroxide*

    PubMed Central

    Mengel, Charles E.; Kann, Herbert E.; Meriwether, Wilhelm D.

    1967-01-01

    When paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes were exposed to H2O2 they lysed excessively and formed greater than normal quantities of lipid peroxides when compared to red cells of normal subjects and patients with most types of hematologic disease. It was also shown that lytic sensitivity to acidified serum was related to the enhanced lytic sensitivity to H2O2. If the lipid of PNH cells was first extracted then exposed to ultraviolet radiation more lipid peroxides were formed than in extracts of normal red blood cells. The possible explanations for these findings and their relationship to the PNH hemolytic mechanism are discussed. Images PMID:6061745

  17. An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function.

    PubMed

    Molthan, L; Matulewicz, T J; Bansal-Carver, B; Benz, E J

    1984-01-01

    A patient with phenotype R2r and anti-C has a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R1r transfusion. Transient impaired renal function ensued. A patient with phenotype R2R2 and anti-Ce+e had the same experience on day 4 after receiving three R1r and one rr units. 2 other patients, 1 R2r with anti-C who received one R1r unit and the other R2R2 with anti-Ce+e who received two R1r units, showed no clinical evidence of HTR. Both anti-C antibodies were entirely IgG while both anti-Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell-mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981.

  18. An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function.

    PubMed

    Molthan, L; Matulewicz, T J; Bansal-Carver, B; Benz, E J

    1984-01-01

    A patient with phenotype R2r and anti-C has a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R1r transfusion. Transient impaired renal function ensued. A patient with phenotype R2R2 and anti-Ce+e had the same experience on day 4 after receiving three R1r and one rr units. 2 other patients, 1 R2r with anti-C who received one R1r unit and the other R2R2 with anti-Ce+e who received two R1r units, showed no clinical evidence of HTR. Both anti-C antibodies were entirely IgG while both anti-Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell-mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981. PMID:6438912

  19. [The evaluation and comparative characteristic of detection of clone of paroxysmal nocturnal hemoglobinuria on reticulocytes using the technique of flow cytometry].

    PubMed

    Naumova, E V; Plekhanova, O S; Lugovskaia, S A; Pochtar', M E; Bugrov, I Iu

    2014-07-01

    The paroxysmal nocturnal hemoglobinuria is a rare clonal disease characterized by somatic mutation of gene PIG-A at the level of stem hematopoietic cell. This process results in disorder of synthesis of glycosil phosphatidyl innozitol (GPI) anchor fixing numerous molecules on membrane of blood cells which protect blood cells from impact of complement. The international society of clinical cytometry (2010) proposed the guidelines of detection of clone of paroxysmal nocturnal hemoglobinuria among erythrocytes, granulocytes and monocytes. The original technique is proposed to evaluate the clone of paroxysmal nocturnal hemoglobinuria in reticulocyte population of blood using method of flow cytofluorometry. The sampling of 160 samples of blood of patients with clinical symptoms of paroxysmal nocturnal hemoglobinuria and anemia was analyzed. Two modes of gatedrawing were applied--using monoclonal antibodies to CD71 (receptor to transferrin) and reagent BD ReticCount. The high correlation was established between size of reticulocytic clone of paroxysmal nocturnal hemoglobinuria evaluated by CD71 and size of granulocytic and monocytic clone of paroxysmal nocturnal hemoglobinuria. The developed panel (CD71/CD235a/CD59) can be applied for screening and monitoring of paroxysmal nocturnal hemoglobinuria.

  20. Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature

    PubMed Central

    Araten, David J.; Notaro, Rosario; Thaler, Howard T; Kernan, Nancy; Boulad, Farid; Castro-Malaspina, Hugo; Small, Trudy; Scaradavou, Andromachi; Magnan, Heather; Prockop, Susan; Chaffee, Sara; Gonsky, Jason; Thertulien, Raymond; Tarquini, Roberto; Luzzatto, Lucio

    2012-01-01

    Background Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis. Design and Methods We reviewed the outcome of thrombolytic therapy for patients with paroxysmal nocturnal hemoglobinuria who had thromboses refractory to anticoagulation at our institutions. Results In this study of 41 patients who had at least one thrombotic event, we confirmed a very high incidence of recurrence despite anticoagulation. Nine patients with thrombosis were regarded as eligible for administration of intravenous tissue plasminogen activator, which was effective in reversing thrombi in all of 15 occasions in which it was given. Serious hemorrhagic complications developed in three cases. At last follow-up visit, of the nine patients treated, three had died, and six were in very good to excellent condition in terms of clinical outcome and radiological findings. The only patient in whom thrombolysis may have contributed to a fatal outcome also had complications of “heparin induced thrombocytopenia with thrombosis”, which we diagnosed in three additional patients. In our review of the literature, nine out of 15 patients treated with thrombolysis have had a good outcome. Conclusions Although it is associated with a significant but manageable risk of bleeding, systemic thrombolysis is a highly effective treatment for reversing venous thromboses in patients with paroxysmal nocturnal hemoglobinuria. PMID:22133780

  1. Reduced-intensity stem cell allografting for PNH patients in the eculizumab era: The Mexican experience.

    PubMed

    Schcolnik-Cabrera, Alejandro; Labastida-Mercado, Nancy; Galindo-Becerra, Laura Samantha; Gomez-Almaguer, David; Herrera-Rojas, Miguel Angel; Ruiz-Delgado, Guillermo Jose; Ruiz-Arguelles, Guillermo José

    2015-06-01

    Background Paroxysmal nocturnal haemoglobinuria (PNH) presents as two major entities: the classical form, predominantly haemolytic and a secondary type with marrow failure and resultant aplastic anaemia (AA-PNH). Currently, the treatment of choice of the haemolytic variant is eculizumab; however, the most frequent form of PNH in México is AA-PNH. Patients and methods Six consecutive AA-PNH patients with HLA-identical siblings were allografted in two institutions in México, employing a reduced-intensity conditioning regimen for stem cell transplantation (RIST) conducted on an outpatient basis. Results Median age of the patients was 37 years (range 25-48). The patients were given a median of 5.4 × 10(6)/kg allogeneic CD34(+) cells, using 1-3 apheresis procedures. Median time to achieve above 0.5 × 10(9)/l granulocytes was 21 days, whereas median time to achieve above 20 × 10(9)/l platelets was 17 days. Five patients are alive for 330-3150 days (median 1437) after the allograft. The 3150-day overall survival is 83.3%, whereas median survival has not been reached, being above 3150 days. Conclusion We have shown that hypoplastic PNH patients can be allografted safely using RIST and that the long-term results are adequate, the cost-benefit ratio of this treatment being reasonable. Additional studies are needed to confirm the usefulness of RIST in the treatment of AA-PNH. PMID:25148373

  2. Detection of paroxysmal nocturnal hemoglobinuria clones in patients with myelodysplastic syndromes and related bone marrow diseases, with emphasis on diagnostic pitfalls and caveats

    PubMed Central

    Wang, Sa A.; Pozdnyakova, Olga; Jorgensen, Jeffrey L.; Medeiros, L. Jeffrey; Stachurski, Dariusz; Anderson, Mary; Raza, Azra; Woda, Bruce A.

    2009-01-01

    Background The presence of paroxysmal nocturnal hemoglobinuria clones in the setting of aplastic anemia or myelodysplastic syndrome has been shown to have prognostic and therapeutic implications. However, the status of paroxysmal nocturnal hemoglobinuria clones in various categories of myelodysplastic syndrome and in other bone marrow disorders is not well-studied. Design and Methods By using multiparameter flow cytometry immunophenotypic analysis with antibodies specific for four glycosylphosphatidylinositol-anchored proteins (CD55, CD59, CD16, CD66b) and performing an aerolysin lysis confirmatory test in representative cases, we assessed the paroxysmal nocturnal hemoglobinuria-phenotype granulocytes in 110 patients with myelodysplastic syndrome, 15 with myelodysplastic/myeloproliferative disease, 5 with idiopathic myelofibrosis and 6 with acute myeloid leukemia. Results Paroxysmal nocturnal hemoglobinuria-phenotype granulocytes were detected in nine patients with low grade myelodysplastic syndrome who showed clinicopathological features of bone marrow failure, similar to aplastic anemia. All paroxysmal nocturnal hemoglobinuria-positive cases demonstrated loss of the four glycosylphosphatidylinositol-anchored proteins, with CD16−CD66b− clones being larger than those of CD55−CD59− (p<0.05). Altered glycosylphosphatidylinositol-anchored protein expression secondary to granulocytic hypogranulation, immaturity, and/or immunophenotypic abnormalities was present in a substantial number of cases and diagnostically challenging. Conclusions These results show that routine screening for paroxysmal nocturnal hemoglobinuria clones in patients with an intrinsic bone marrow disease who show no clinical evidence of hemolysis has an appreciable yield in patients with low grade myelodysplastic syndromes. The recognition of diagnostic caveats and pitfalls associated with the underlying intrinsic bone marrow disease is essential in interpreting paroxysmal nocturnal

  3. Unilateral moyamoya syndrome involving the ipsilateral anterior and posterior circulation associated with paroxysmal nocturnal hemoglobinuria.

    PubMed

    Mugikura, Shunji; Higano, Shuichi; Fujimura, Miki; Shimizu, Hiroaki; Takahashi, Shoki

    2010-04-01

    Moyamoya refers to a phenomenon of stenoocclusive changes at or around the terminal part of the internal carotid artery (ICA). Moyamoya vessels develop in patients with (moyamoya syndrome) or without (moyamoya disease) various underlying diseases or conditions. Recent evidence shows that stenoocclusive lesions tend to involve the ipsilateral ICA system and posterior cerebral artery (PCA) predominantly in moyamoya disease. A 53-year-old Japanese woman with paroxysmal nocturnal hemoglobinuria presented with cerebral infarction from stenoocclusive involvement in the ipsilateral ICA and PCA associated with moyamoya vessels; she had no contralateral vascular lesion. Although predominant involvement of the ipsilateral ICA and PCA was associated with underlying disease (moyamoya syndrome) in the present case, it is a characteristic finding of moyamoya disease. We discuss the possible pathogenesis of the vascular changes of this case.

  4. Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

    PubMed Central

    Lin, Zhuoer; Schmidt, Christoph Q.; Koutsogiannaki, Sophia; Ricci, Patrizia; Risitano, Antonio M.; Lambris, John D.

    2015-01-01

    The clinical management of paroxysmal nocturnal hemoglobinuria (PNH), a rare but life-threatening hematologic disease, has fundamentally improved with the introduction of a therapeutic that prevents complement-mediated intravascular hemolysis. However, a considerable fraction of PNH patients show insufficient treatment response and remain transfusion dependent. Because the current treatment only prevents C5-induced lysis but not upstream C3 activation, it has been speculated that ongoing opsonization with C3 fragments leads to recognition and phagocytosis of PNH erythrocytes by immune cells. Here, for the first time, we provide experimental evidence for such extravascular hemolysis and demonstrate that PNH erythrocytes from anti–C5-treated patients are phagocytosed by activated monocytes in vitro. Importantly, we show that this uptake can be mediated by the end-stage opsonin C3dg, which is not traditionally considered a phagocytic marker, via interaction with complement receptor 3 (CR3). Interaction studies confirmed that C3dg itself can act as a ligand for the binding domain of CR3. The degree of C3dg-mediated erythrophagocytosis in samples from different PNH patients correlated well with the individual level of C3dg opsonization. This finding may guide future treatment options for PNH but also has potential implications for the description and management of other complement-mediated diseases. PMID:26082452

  5. Synthesis of aberrant decay-accelerating factor proteins by affected paroxysmal nocturnal hemoglobinuria leukocytes.

    PubMed Central

    Carothers, D J; Hazra, S V; Andreson, S W; Medof, M E

    1990-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) leukocytes fail to express decay-accelerating factor (DAF) but contain DAF mRNA transcripts resembling those in normal cells. To further investigate the nature of the DAF defect in affected cells, patients' polymorphonuclear and mononuclear leukocytes (PMN and MNC) were biosynthetically labeled and newly synthesized DAF proteins examined. Analyses of greater than 98% surface DAF-negative PMN and MNC from a patient with PNH III erythrocytes showed precursor DAF protein approximately 3 kD smaller in each cell type than in normal cells. The proportion of precursor to mature (O-glycosylated) DAF protein was increased and soluble DAF protein was detected in the medium. Studies of 70-80% surface DAF-negative PMN and MNC from four patients with type II erythrocytes showed mixtures of the 3 kD smaller and normal DAF precursors. Partitioning with Triton X-114 detergent and biosynthetic labeling with the anchor precursor [3H]ethanolamine indicated that the abnormal peptides lacked glycosyl-inositolphospholipid membrane-anchoring structures. Thus, in PNH cells nascent DAF polypeptides are synthesized. Some of the abnormal pro-DAF molecules are processed in the Golgi and some are released extracellularly. Images PMID:1688570

  6. Terminal Complement Blockade after Hematopoietic Stem Cell Transplantation Is Safe without Meningococcal Vaccination.

    PubMed

    Jodele, Sonata; Dandoy, Christopher E; Danziger-Isakov, Lara; Myers, Kasiani C; El-Bietar, Javier; Nelson, Adam; Wallace, Gregory; Teusink-Cross, Ashley; Davies, Stella M

    2016-07-01

    Eculizumab inhibits terminal complement-mediated intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and complement-mediated thrombotic microangiopathy (TMA) in patients with atypical hemolytic uremic syndrome and is now used as a first-line therapy in these diseases. Eculizumab is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) because of an increased risk of meningococcal infections in persons without adequate functional complement. Administration of meningococcal vaccine is required at least 2 weeks before administering the first dose of eculizumab, and this advice is included in the product label. Eculizumab use for treatment of TMA in hematopoietic stem cell transplantation (HSCT) recipients brings a significant dilemma regarding REMS required meningococcal vaccination. TMA after HSCT usually occurs within the first 100 days after transplantation when patients are severely immunocompromised and are not able to mount a response to vaccines. We evaluated 30 HSCT recipients treated with eculizumab for high-risk TMA without meningococcal vaccine. All patients received antimicrobial prophylaxis adequate for Neisseria meningitides during eculizumab therapy and for 8 weeks after discontinuation of the drug. Median time to TMA diagnosis was 28 days after transplant (range, 13.8 to 48.5). Study subjects received a median of 14 eculizumab doses (range, 2 to 38 doses) for HSCT-associated TMA therapy. There were no incidences of meningococcal infections. The incidences of bacterial and fungal bloodstream infections were similar in patients treated with eculizumab (n = 30) as compared with those with HSCT-associated TMA who did not receive any complement blocking therapy (n = 39). Our data indicate that terminal complement blockade in the early post-transplant period can be performed without meningococcal vaccination while using appropriate antimicrobial prophylaxis until complement

  7. Case Report: Paroxysmal nocturnal hemoglobinuria in a woman heterozygous for G6PD A-.

    PubMed

    Perdigones, Nieves; Morales, Mariela; Mason, Philip; Bessler, Monica

    2014-01-01

    We describe a case of paroxysmal nocturnal hemoglobinuria (PNH) in a woman who is heterozygous for the glucose-6-phosphate dehydrogenase A-   ( G6PDA-) allele. PNH is associated with one or more clones of cells that lack complement inhibition due to loss of function somatic mutations in the PIGA gene.  PIGA encodes the enzyme phosphatidylinositol glycan anchor biosynthesis, class A, which catalyses the first step of glycosylphosphatidylinisotol ( GPI)  anchor synthesis. Two GPI anchored red cell surface antigens regulate complement lysis. G6PD catalyses the first step of the pentose phosphate pathway and enzyme variants, frequent in some populations have been selected because they confer resistance to malaria, are associated with hemolysis in the presence of oxidizing agents including several drugs. The patient had suffered a hemolytic attack after taking co-trimoxazole, a drug that precipitates hemolysis in G6PD deficient individuals. Since both G6PD and PIGA are X-linked we hypothesized that the PIGA mutation was on the X-chromosome carrying the G6PDA- allele. Investigations showed that in fact the PIGA mutation was on the X-chromosome carrying the normal G6PD B allele. We speculate that complement activation on G6PD A- red cells exposed to Bactrim might have triggered complement activation inducing the lysis of G6PD B PNH Type II red blood cells or that the patient may have had a PNH clone expressing G6PDA- at the time of the hemolytic episode. PMID:25713697

  8. The patterns of MHC association in aplastic and non-aplastic paroxysmal nocturnal hemoglobinuria.

    PubMed

    Nowak, Jacek; Mika-Witkowska, Renata; Mendek-Czajkowska, Ewa; Rogatko-Koroś, Marta; Graczyk-Pol, Elżbieta; Pyl, Hanna; Klimczak, Aneta; Wójcik, Małgorzata; Prochorec-Sobieszek, Monika; Maryniak, Renata; Zupańska, Barbara

    2011-06-01

    The deficiency of glycosyl-phosphatidylinositol (GPI)-anchored proteins in plasma membranes of PIG-A gene mutated hematopoietic stem cells (HSCs) is so far insufficient to explain the domination of paroxysmal nocturnal hemoglobinuria (PNH) clone over the normal HSC. We attempted to elucidate possible link between MHC and initial severe aplastic anemia (ISAA/PNH) type and non-aplastic (n/PNH) outcome of PNH. In 50 PNH patients assigned as ISAA/PNH (n = 13), n/PNH (n = 33) or nonassigned (n = 4) and 200 ethnically matched controls we analyzed MHC associations. Our data confirmed strong associations of DRB1*15:01 (RR = 3.51, p = 0.0011) and DQB1*06:02 (RR = 7.09, p = 0.000026) alleles, especially with n/PNH subtype. B*18:01 allele was associated with increased risk of ISAA/PNH subtype (RR = 5.25, p = 0.0028). We conclude that both class II and class I MHC alleles are associated with different subsets of PNH. Clonal selection of PIG-A mutated cells with cognate metabolic block is associated with MHC class II alleles DRB1*15:01 and DQB1*06:02 independent from initial severe AA clone selection. MHC class I molecule B*18:01 can additionally influence the domination of PNH clone in PNH subjects with initial severe aplastic anemia.

  9. A comparative analysis of clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria between Asia and Europe/America.

    PubMed

    Yu, Fan; Du, Yali; Han, Bing

    2016-06-01

    To accurately analyze the clinical characteristics of paroxysmal nocturnal hemoglobinuria (PNH) in different ethnic backgrounds, we retrieved all retrospective studies on clinical characteristics of PNH with a median follow-up period >60 months published after 2000, analyzed the clinical characteristics of PNH patients in Asia and European/America, and statistically compared enumeration data in these studies. We included 1665 patients in this analysis. The proportion of female patients in Asia was significantly lower than that in Europe/America (P = 0.000). Incidence rates of hemoglobinuria and thromboembolism in Asia were significantly lower than in Europe/America (both P values were 0.000). Within the subgroups of patients with thromboembolism, Asian patients had a higher proportion of arterial thrombosis while Western patients had a higher proportion of abdominal venous thrombosis. Bone marrow failure was not clearly defined in most studies. The proportion of patients with pancytopenia was higher in China than in France (P = 0.048). The total death rates were similar in both ethnic groups (P > 0.05). In Europe/America the major cause of death was thromboembolism and in Asian countries was serious infections. Differences in population characteristics of PNH patients among different ethnic groups indicate the possibility of differential pathogenesis and may be informative for treatment decisions.

  10. The study on RBC characteristic in paroxysmal nocturnal hemoglobinuria (PNH) patients using common path interferometric quantitative phase microscopy

    NASA Astrophysics Data System (ADS)

    Park, Byung Jun; Won, Youngjae; Kim, Byungyeon; Lee, Seungrag

    2016-03-01

    We have studied the RBC membrane properties between a normal RBC and a RBC in Paroxysrnal nocturnal hemoglobinuria (PNH) patient using common path interferometric quantitative phase microscopy (CPIQPM). CPIQPM system has provided the subnanometer optical path length sensitivity on a millisecond. We have measured the dynamic thickness fluctuations of a normal RBC membrane and a RBC membrane in PNH patient over the whole cell surface with CPIQPM. PNH is a rare and serious disease of blood featured by destruction of red blood cells (RBCs). This destruction happens since RBCs show the defect of protein which protects RBCs from the immune system. We have applied CPIQPM to study the characteristic of RBC membrane in PNH patient. We have shown the morphological shape, volume, and projected surface for both different RBC types. The results have showed both RBCs had the similar shape with donut, but membrane fluctuations in PNH patient was shown to reveal the difference of temporal properties compared with a normal RBC. In order to demonstrate the practical tool of the CPIQPM technique, we have also obtained the time series thickness fluctuation outside a cell.

  11. Paroxysmal nocturnal hemoglobinuria with copy number-neutral 6pLOH in GPI (+) but not in GPI (-) granulocytes.

    PubMed

    Ueda, Yasutaka; Nishimura, Jun-ichi; Murakami, Yoshiko; Kajigaya, Sachiko; Kinoshita, Taroh; Kanakura, Yuzuru; Young, Neal S

    2014-01-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired bone marrow disorder caused by expansion of a clone of hematopoietic cells lacking glycosylphosphatidylinositol (GPI)-anchored membrane proteins. Multiple lines of evidence suggest immune attack on normal hematopoietic stem cells provides a selective growth advantage to PNH clones. Recently, frequent loss of HLA alleles associated with copy number-neutral loss of heterozygosity in chromosome 6p (CN-6pLOH) in aplastic anemia (AA) patients was reported, suggesting that AA hematopoiesis 'escaped' from immune attack by loss of HLA alleles. We report here the first case of CN-6pLOH in a Japanese PNH patient only in GPI-anchored protein positive (59%) granulocytes, but not in GPI-anchored protein negative (41%) granulocytes. CN-6pLOH resulted in loss of the alleles A*02:06-DRB1*15:01-DQB1*06:02, which have been reported to be dominant in Japanese PNH patients. Our patient had maintained nearly normal blood count for several years. Our case supports the hypothesis that a hostile immune environment drives selection of resistant hematopoietic cell clones and indicates that clonal evolution may occur also in normal phenotype (non-PNH) cells in some cases.

  12. Serum-Red Cell Interactions at Low Ionic Strength: Erythrocyte Complement Coating and Hemolysis of Paroxysmal Nocturnal Hemoglobinuria Cells*

    PubMed Central

    Jenkins, David E.; Hartmann, Robert C.; Kerns, Albert L.

    1967-01-01

    Complement coating and hemolysis were observed when erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) were incubated in isotonic sucrose solution in the presence of small amounts of serum. Normal cells were likewise coated with complement components but did not hemolyze. Both normal and PNH erythrocytes reduced the hemolytic complement activity of the serum used in this reaction. Experience with other simple saccharides and related compounds suggests that the low ionic strength of the sucrose solution is the feature that permitted complement coating of red cells and hemolysis of PNH erythrocytes. Isotonic solutions of other sugars or sugar alcohols that do not readily enter human erythrocytes could be substituted for sucrose. The mechanism for these reactions may possibly relate to the agglutination observed with erythrocytes tested in the serum-sucrose system. Even though PNH hemolytic activity could be removed by prior heating of serum or barium sulfate treatment of plasma, the agglutination phenomenon still persisted. The in vitro conditions necessary for optimal sucrose hemolysis of PNH erythrocytes were described and compared with those of the classical acid hemolysis test. The requirement for less serum in the sucrose hemolysis system than needed in the standard acid hemolysis reaction makes certain experiments, especially those using large amounts of autologous PNH serum, much more feasible. Additional advantages of the sucrose hemolysis test are that it can be carried out at room temperature in the presence of oxalate and citrate and that critical pH control is not essential. To date, the sucrose hemolysis test has been a sensitive and specific one for PNH. A modified test used for screening purposes, the “sugar water” test, is very easy to perform. PMID:6025481

  13. Paroxysmal nocturnal hemoglobinuria (PNH)

    MedlinePlus

    ... blood cells that are missing a gene called PIG-A. This gene allows a substance called glycosyl- ... to help certain proteins stick to cells. Without PIG-A, important proteins cannot connect to the cell ...

  14. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    MedlinePlus

    ... Blood consists of blood cells floating in plasma . Plasma is mostly made of water. It also includes salts, proteins, hormones, minerals, vitamins and other nutrients and chemicals your body needs. What are the 3 Basic Types of Blood Cells? Red blood cells ( ...

  15. Paroxysmal cold hemoglobinuria (PCH)

    MedlinePlus

    ... the urine. PCH has been linked to secondary syphilis, tertiary syphilis, and other viral or bacterial infections. Sometimes the ... help. For example, if PCH is caused by syphilis, symptoms may get better when the syphilis is ...

  16. CALUTRON RECEIVER

    DOEpatents

    Barnes, S.W.

    1959-08-25

    An improvement in a calutron receiver for collecting the isotopes ts described. The electromagnetic separation of the isotopes produces a mass spectrum of closely adjacent beams of ions at the foci regions, and a dividing wall between the two pockets is arranged at an angle. Substantially all of the tons of the less abundant isotope enter one of the pockets and strike one side of the wall directly, while substantially none of the tons entering the other pocket strikes the wall directly.

  17. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.

    PubMed

    Risitano, Antonio M; Notaro, Rosario; Pascariello, Caterina; Sica, Michela; del Vecchio, Luigi; Horvath, Christopher J; Fridkis-Hareli, Masha; Selleri, Carmine; Lindorfer, Margaret A; Taylor, Ronald P; Luzzatto, Lucio; Holers, V Michael

    2012-06-28

    Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis because of the lack from erythrocyte surface of the complement regulators CD55 and CD59, with subsequent uncontrolled continuous spontaneous activation of the complement alternative pathway (CAP), and at times of the complement classic pathway. Here we investigate in an in vitro model the effect on PNH erythrocytes of a novel therapeutic strategy for membrane-targeted delivery of a CAP inhibitor. TT30 is a 65 kDa recombinant human fusion protein consisting of the iC3b/C3d-binding region of complement receptor 2 (CR2) and the inhibitory domain of the CAP regulator factor H (fH). TT30 completely inhibits in a dose-dependent manner hemolysis of PNH erythrocytes in a modified extended acidified serum assay, and also prevents C3 fragment deposition on surviving PNH erythrocytes. The efficacy of TT30 derives from its direct binding to PNH erythrocytes; if binding to the erythrocytes is disrupted, only partial inhibition of hemolysis is mediated by TT30 in solution, which is similar to that produced by the fH moiety of TT30 alone, or by intact human fH. TT30 is a membrane-targeted selective CAP inhibitor that may prevent both intravascular and C3-mediated extravascular hemolysis of PNH erythrocytes and warrants consideration for the treatment of PNH patients.

  18. Radiation receiver

    DOEpatents

    Hunt, Arlon J.

    1983-01-01

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

  19. Radiation receiver

    DOEpatents

    Hunt, A.J.

    1983-09-13

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

  20. Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane.

    PubMed

    Blaas, P; Berger, B; Weber, S; Peter, H H; Hänsch, G M

    1988-05-01

    Recently, a protein isolated from the membrane of human E, the so-called C8 binding protein (C8bp), has been described. C8bp is characterized as a 65-kDa protein that binds to C8 and inhibits the C5b-9-mediated lysis in a homologous system. In the present study, membranes of peripheral blood cells were tested for the presence of C8bp by SDS-PAGE and immunoblotting. In all cells a protein band reacting with anti-C8bp was seen, the Mr, however, was only about 50 kDa. To further analyze the 50-kDa protein, we isolated the protein by phenol-water extraction and isoelectric focusing from papain-treated platelets. The isolated protein behaved similar to the E-derived C8bp: it inhibited the lysis of model target cells by C5b-9. To examine the function of C8bp in platelets, we tested platelets from patients suffering from paroxysmal nocturnal hemoglobinuria (PNH). These platelets were deficient in C8bp, being in accordance with their higher lytic susceptibility in vitro. In response to sublytic C5b-9 doses, the PNH platelets released considerably more serotonin and thromboxane B2 than normal platelets. By addition of purified C8bp, the thromboxane B2 release was suppressed, indicating that C8bp not only restricts the lytic complement attack, but also regulates the C5b-9-mediated stimulation of target cells. Thus, lack of C8bp might not only result in enhanced hemolysis, but also in enhanced stimulation of platelets, which in turn might contribute to the thrombotic complications seen in some PNH-type III patients.

  1. Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins.

    PubMed Central

    Edberg, J C; Salmon, J E; Whitlow, M; Kimberly, R P

    1991-01-01

    The isoform of Fc gamma RIII (CD16) expressed on PMN has a GPI membrane anchor, and in paroxysmal nocturnal hemoglobinuria (PNH) there is a deficiency in Fc gamma RIII expression on PMN. Contrary to expectation, however, CD16 expression is preserved (albeit at reduced levels) in all affected PNH PMN that completely lack the GPI-anchored proteins DAF (CD55) and CD59. Fc gamma RIII negative PMN are not observed in any of the six PNH patients examined in this study. Analysis of the molecular weight of both glycosylated and deglycosylated Fc gamma RIII from PMN with reduced Fc gamma RIII expression indicates no variations in size relative to normal donor Fc gamma RIIIPMN. Indeed, the Fc gamma RIII expressed at intermediate levels is phosphatidylinositol-specific phospholipase C (PI-PLC)-sensitive. Thus, there is no evidence suggestive of expression of a transmembrane isoform and all data indicate that Fc gamma RIIIPMN on affected cells in PNH is a GPI-linked isoform. With Fc gamma RIIIPMN expression preserved at reduced levels on affected cells in PNH, PMN from PNH patients retain the capacity to internalize the Fc gamma RIIIPMN-specific probe E-ConA (at reduced levels) as well as IgG-opsonized erythrocytes. Reduced expression of GPI-anchored molecules on PNH PMN is not restricted to Fc gamma RIIIPMN since intermediate levels of CD59 were observed in the PNH PMN that were decay-accelerating factor (DAF)-negative and Fc gamma RIIIPMN intermediate. In addition, discordant expression of GPI-linked molecules in individual cells is not restricted to PMN since DAF+/CD14- monocytes were observed in one PNH patient. These data suggest that, when analyzed on an individual cell level, the GPI anchor defect in PNH is not absolute and must involve either a hierarchy of access of different protein molecules to available GPI anchors, distinct anchor biochemistries for the different proteins, or differential regulation of protein-anchor assembly. Images PMID:1702101

  2. The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria.

    PubMed

    Ware, R E; Nishimura, J; Moody, M A; Smith, C; Rosse, W F; Howard, T A

    1998-10-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disorder characterized by complement-mediated hemolysis and deficient hematopoiesis. The development of PNH involves an acquired mutation in the X-linked PIG-A gene, which leads to incomplete bioassembly of glycosylphosphatidylinositol (GPI) anchors and absent or reduced surface expression of GPI-linked proteins. The origin and mechanisms by which the PNH clone becomes dominant are not well understood, but recently resistance to apoptosis has been postulated. To test the hypothesis that the PIG-A mutation and absence of GPI-linked surface proteins directly confer resistance to apoptosis, we isolated peripheral granulocytes from 26 patients with PNH and 20 normal controls and measured apoptosis induced by serum starvation. Granulocytes from patients with PNH were relatively resistant to apoptosis (38.8% +/- 14.1%) as compared with granulocytes from controls (55.0% +/- 12.0%, P < .001). However, this resistance to apoptosis was not related to the dominance of the PNH clone because patients with a low percentage of GPI-deficient granulocytes had a similar rate of apoptosis as those with a high percentage of GPI-deficient granulocytes. Similarly, the resistance to granulocyte apoptosis was not influenced by the degree of neutropenia or a prior history of aplastic anemia. To investigate formally the importance of GPI-linked surface proteins in apoptosis, we introduced the PIG-A cDNA sequence into the JY5 GPI-negative B-lymphoblastoid cell line using two different methods: (1) stable transfection of a plasmid containing PIG-A, and (2) stable transduction of a retroviral vector containing PIG-A. We then measured rates of apoptosis induced either by Fas antibody, serum starvation, or gamma-irradiation. With each stimulus, apoptosis of JY5 with stable surface expression of GPI-linked proteins was not statistically different from the parent JY5 cell line or the JY25 (GPI-positive) cell line. Our data confirm

  3. Spaceborne receivers: Basic principles

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1984-01-01

    The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.

  4. Solar heat receiver

    DOEpatents

    Hunt, Arlon J.; Hansen, Leif J.; Evans, David B.

    1985-01-01

    A receiver for converting solar energy to heat a gas to temperatures from 700.degree.-900.degree. C. The receiver is formed to minimize impingement of radiation on the walls and to provide maximum heating at and near the entry of the gas exit. Also, the receiver is formed to provide controlled movement of the gas to be heated to minimize wall temperatures. The receiver is designed for use with gas containing fine heat absorbing particles, such as carbon particles.

  5. Solar heat receiver

    DOEpatents

    Hunt, A.J.; Hansen, L.J.; Evans, D.B.

    1982-09-29

    A receiver is described for converting solar energy to heat a gas to temperatures from 700 to 900/sup 0/C. The receiver is formed to minimize impingement of radiation on the walls and to provide maximum heating at and near the entry of the gas exit. Also, the receiver is formed to provide controlled movement of the gas to be heated to minimize wall temperatures. The receiver is designed for use with gas containing fine heat absorbing particles, such as carbon particles.

  6. Hybrid receiver study

    NASA Technical Reports Server (NTRS)

    Stone, M. S.; Mcadam, P. L.; Saunders, O. W.

    1977-01-01

    The results are presented of a 4 month study to design a hybrid analog/digital receiver for outer planet mission probe communication links. The scope of this study includes functional design of the receiver; comparisons between analog and digital processing; hardware tradeoffs for key components including frequency generators, A/D converters, and digital processors; development and simulation of the processing algorithms for acquisition, tracking, and demodulation; and detailed design of the receiver in order to determine its size, weight, power, reliability, and radiation hardness. In addition, an evaluation was made of the receiver's capabilities to perform accurate measurement of signal strength and frequency for radio science missions.

  7. Data-fusion receiver

    SciTech Connect

    Gabelmann, Jeffrey M.; Kattner, J. Stephen; Houston, Robert A.

    2006-12-19

    This invention is an ultra-low frequency electromagnetic telemetry receiver which fuses multiple input receive sources to synthesize a decodable message packet from a noise corrupted telemetry message string. Each block of telemetry data to be sent to the surface receiver from a borehole tool is digitally encoded into a data packet prior to transmission. The data packet is modulated onto the ULF EM carrier wave and transmitted from the borehole to the surface and then are simultaneously detected by multiple receive sensors disbursed within the rig environment. The receive sensors include, but are not limited to, electric field and magnetic field sensors. The spacing of the surface receive elements is such that noise generators are unequally coupled to each receive element due to proximity and/or noise generator type (i.e. electric or magnetic field generators). The receiver utilizes a suite of decision metrics to reconstruct the original, non noise-corrupted data packet from the observation matrix via the estimation of individual data frames. The receiver will continue this estimation process until: 1) the message validates, or 2) a preset "confidence threshold" is reached whereby frames within the observation matrix are no longer "trusted".

  8. CALUTRON RECEIVER STRUCTURE

    DOEpatents

    Roush, J.L.

    1959-09-01

    A receiver is described for collecting isotopes in a calutron The receiver has several compartments, formed by a sertes of parallel metal plates and an open front. Each plate has flanges which space it from the other plates and a flexible extension pressing against a common supporting red to maintain the plate in assembled relation when all but the last rod is removed. The plates may be removed individualy from the front of the receiver, cleaned ard replaced without disturbing the alignment of the other plates.

  9. Ultrasonic pulser-receiver

    DOEpatents

    Taylor, Steven C.

    2006-09-12

    Ultrasonic pulser-receiver circuitry, for use with an ultrasonic transducer, the circuitry comprising a circuit board; ultrasonic pulser circuitry supported by the circuit board and configured to be coupled to an ultrasonic transducer and to cause the ultrasonic transducer to emit an ultrasonic output pulse; receiver circuitry supported by the circuit board, coupled to the pulser circuitry, including protection circuitry configured to protect against the ultrasonic pulse and including amplifier circuitry configured to amplify an echo, received back by the transducer, of the output pulse; and a connector configured to couple the ultrasonic transducer directly to the circuit board, to the pulser circuitry and receiver circuitry, wherein impedance mismatches that would result if the transducer was coupled to the circuit board via a cable can be avoided.

  10. Solar energy receiver

    DOEpatents

    Schwartz, Jacob

    1978-01-01

    An improved long-life design for solar energy receivers provides for greatly reduced thermally induced stress and permits the utilization of less expensive heat exchanger materials while maintaining receiver efficiencies in excess of 85% without undue expenditure of energy to circulate the working fluid. In one embodiment, the flow index for the receiver is first set as close as practical to a value such that the Graetz number yields the optimal heat transfer coefficient per unit of pumping energy, in this case, 6. The convective index for the receiver is then set as closely as practical to two times the flow index so as to obtain optimal efficiency per unit mass of material.

  11. Receiver Gain Modulation Circuit

    NASA Technical Reports Server (NTRS)

    Jones, Hollis; Racette, Paul; Walker, David; Gu, Dazhen

    2011-01-01

    A receiver gain modulation circuit (RGMC) was developed that modulates the power gain of the output of a radiometer receiver with a test signal. As the radiometer receiver switches between calibration noise references, the test signal is mixed with the calibrated noise and thus produces an ensemble set of measurements from which ensemble statistical analysis can be used to extract statistical information about the test signal. The RGMC is an enabling technology of the ensemble detector. As a key component for achieving ensemble detection and analysis, the RGMC has broad aeronautical and space applications. The RGMC can be used to test and develop new calibration algorithms, for example, to detect gain anomalies, and/or correct for slow drifts that affect climate-quality measurements over an accelerated time scale. A generalized approach to analyzing radiometer system designs yields a mathematical treatment of noise reference measurements in calibration algorithms. By treating the measurements from the different noise references as ensemble samples of the receiver state, i.e. receiver gain, a quantitative description of the non-stationary properties of the underlying receiver fluctuations can be derived. Excellent agreement has been obtained between model calculations and radiometric measurements. The mathematical formulation is equivalent to modulating the gain of a stable receiver with an externally generated signal and is the basis for ensemble detection and analysis (EDA). The concept of generating ensemble data sets using an ensemble detector is similar to the ensemble data sets generated as part of ensemble empirical mode decomposition (EEMD) with exception of a key distinguishing factor. EEMD adds noise to the signal under study whereas EDA mixes the signal with calibrated noise. It is mixing with calibrated noise that permits the measurement of temporal-functional variability of uncertainty in the underlying process. The RGMC permits the evaluation of EDA by

  12. Central solar energy receiver

    DOEpatents

    Drost, M. Kevin

    1983-01-01

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  13. Silicon Photo-Receivers

    NASA Astrophysics Data System (ADS)

    Zimmermann, Horst

    The properties of photodiodes being exploitable in standard bipolar, CMOS, and BiCMOS technologies are summarized. In addition examples of advanced photodiodes will be introduced in order to show how the properties of integrated photodiodes can be improved significantly by minor process modifications. Furthermore, examples of optoelectronic integrated circuits (OEICs) for such important applications like optical storage systems and optical fiber receivers are described. New trends for the circuit topology of digital-video-disk (DVD) and digital-video-recording (DVR) read-OEICs are covered. Progress of OEIC receivers for optical data transmission and communication as well as optical interconnects is also summarized.

  14. Zero-power receiver

    DOEpatents

    Brocato, Robert W.

    2016-10-04

    An unpowered signal receiver and a method for signal reception detects and responds to very weak signals using pyroelectric devices as impedance transformers and/or demodulators. In some embodiments, surface acoustic wave devices (SAW) are also used. Illustrative embodiments include satellite and long distance terrestrial communications applications.

  15. Submillimeter wave heterodyne receiver

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam (Inventor); Manohara, Harish (Inventor); Siegel, Peter H. (Inventor); Ward, John (Inventor)

    2011-01-01

    In an embodiment, a submillimeter wave heterodyne receiver includes a finline ortho-mode transducer comprising thin tapered metallic fins deposited on a thin dielectric substrate to separate a vertically polarized electromagnetic mode from a horizontally polarized electromagnetic mode. Other embodiments are described and claimed.

  16. Simplified OMEGA receivers

    NASA Technical Reports Server (NTRS)

    Burhans, R. W.

    1974-01-01

    The details are presented of methods for providing OMEGA navigational information including the receiver problem at the antenna and informational display and housekeeping systems based on some 4 bit data processing concepts. Topics discussed include the problem of limiters, zero crossing detectors, signal envelopes, internal timing circuits, phase counters, lane position displays, signal integrators, and software mapping problems.

  17. Olympus beacon receiver

    NASA Technical Reports Server (NTRS)

    Ostergaard, Jens

    1988-01-01

    A medium-size Beacon Receiving System for reception and processing of the B1 (20 GHz) and B2 (30 GHz) beacons from Olympus has been developed. Integration of B1 and B2 receiving equipment into one system using one antenna and a common computer for control and data processing provides the advantages of a compact configuration and synchronization of the two receiver chains. Range for co-polar signal attenuation meaurement is about 30 dB for both beacons, increasing to 40 dB for B2 if the receivers are synchronized to B1. The accuracy is better than 0.5 dB. Cross-polarization discriminations of the order of 10 to 30 dB may be determined with an accuracy of 1 to 2 dB. A number of radiometers for complementary measurements of atmospheric attenuation of 13 to 30 GHz has also been constructed. A small multi-frequency system for operation around 22 GHz and 31 GHz is presently under development.

  18. Hanson receives Macelwane Medal

    NASA Astrophysics Data System (ADS)

    Ravishankara, A. R.; Hanson, David R.

    At the 1996 Spring Meeting in Baltimore, Maryland, David R. Hanson received the 1996 James B. Macelwane Medal, which recognizes significant contributions to the geophysical sciences by a young scientist of outstanding ability. The medal citation and Hanson's response are given here.

  19. A digital beacon receiver

    NASA Technical Reports Server (NTRS)

    Ransome, Peter D.

    1988-01-01

    A digital satellite beacon receiver is described which provides measurement information down to a carrier/noise density ratio approximately 15 dB below that required by a conventional (phase locked loop) design. When the beacon signal fades, accuracy degrades gracefully, and is restored immediately (without hysteresis) on signal recovery, even if the signal has faded into the noise. Benefits of the digital processing approach used include the minimization of operator adjustments, stability of the phase measuring circuits with time, repeatability between units, and compatibility with equipment not specifically designed for propagation measuring. The receiver has been developed for the European Olympus satellite which has continuous wave (CW) beacons at 12.5 and 29.7 GHz, and a switched polarization beacon at 19.8 GHz approximately, but the system can be reconfigured for CW and polarization-switched beacons at other frequencies.

  20. Multichannel homodyne receiver

    DOEpatents

    Landt, Jeremy A.

    1982-01-01

    A homodyne radar transmitter/receiver device which produces a single combined output which contains modulated backscatter information for all phase conditions of both modulated and unmodulated backscatter signals. The device utilizes taps along coaxial transmission lines, strip transmission line, and waveguides which are spaced by 1/8 wavelength or 1/6 wavelength, etc. This greatly reduces costs by eliminating separate transmission and reception antennas and an expensive arrangement of power splitters and mixers utilized in the prior art.

  1. Multichannel homodyne receiver

    DOEpatents

    Landt, J.A.

    1981-01-19

    A homodyne radar transmitter/receiver device which produces a single combined output which contains modulated backscatter information for all phase conditions of both modulated and unmodulated backscatter signals is described. The device utilizes taps along coaxial transmission lines, strip transmission line, and waveguides which are spaced by 1/8 wavelength or 1/6 wavelength, etc. This greatly reduces costs by eliminating separate transmission and reception antennas and an expensive arrangement of power splitters and mixers utilized in the prior art.

  2. Design of radar receivers

    NASA Astrophysics Data System (ADS)

    Sokolov, M. A.

    This handbook treats the design and analysis of of pulsed radar receivers, with emphasis on elements (especially IC elements) that implement optimal and suboptimal algorithms. The design methodology is developed from the viewpoint of statistical communications theory. Particular consideration is given to the synthesis of single-channel and multichannel detectors, the design of analog and digital signal-processing devices, and the analysis of IF amplifiers.

  3. Ultra-wideband receiver

    DOEpatents

    McEwan, Thomas E.

    1996-01-01

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, .+-.UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals.

  4. Ultra-wideband receiver

    DOEpatents

    McEwan, Thomas E.

    1994-01-01

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, .+-.UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals.

  5. Ultra-wideband receiver

    DOEpatents

    McEwan, T.E.

    1996-06-04

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, {+-}UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals. 21 figs.

  6. Ultra-wideband receiver

    DOEpatents

    McEwan, T.E.

    1994-09-06

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, [+-] UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals. 16 figs.

  7. Central receiver technology

    SciTech Connect

    Holl, R.L. )

    1989-09-01

    The research and development described in this document was conducted within the US Department of Energy's (DOE) Solar Thermal Technology Program. The goal of this program is to advance the engineering and scientific understanding of solar thermal technology and to establish the technology base from which private industry can develop solar thermal power production options for introduction into the competitive energy market. This report describes central receiver technology: its accomplishments to date, its current technology status, and the efforts still necessary to fully exploit it.

  8. Weather Data Receiver

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Northern Video Graphics, Inc. developed a low-cost satellite receiving system for users such as independent meteorologists, agribusiness firms, small airports or flying clubs, marine vessels and small TV stations. Called Video Fax, it is designed for use with certain satellites; the GOES (Geostationary Operational Environmental Satellite) spacecraft operated by the National Oceanic and Atmospheric Administration, the European Space Agency's Meteosat and Japan's Geostationary Meteorological Satellite. By dictum of the World Meteorological Organization, signals from satellites are available to anyone without cost so the Video Fax user can acquire signals directly from the satellite and cut out the middle man, enabling savings. Unit sells for about one-fifth the cost of the equipment used by TV stations. It consists of a two-meter antenna; a receiver; a microprocessor-controlled display computer; and a video monitor. Computer stores data from the satellites and converts it to an image which is displayed on the monitor. Weather map can be preserved as signal data on tape, or it can be stored in a video cassette as a permanent image.

  9. Digital Receiver Phase Meter

    NASA Technical Reports Server (NTRS)

    Marcin, Martin; Abramovici, Alexander

    2008-01-01

    The software of a commercially available digital radio receiver has been modified to make the receiver function as a two-channel low-noise phase meter. This phase meter is a prototype in the continuing development of a phase meter for a system in which radiofrequency (RF) signals in the two channels would be outputs of a spaceborne heterodyne laser interferometer for detecting gravitational waves. The frequencies of the signals could include a common Doppler-shift component of as much as 15 MHz. The phase meter is required to measure the relative phases of the signals in the two channels at a sampling rate of 10 Hz at a root power spectral density <5 microcycle/(Hz)1/2 and to be capable of determining the power spectral density of the phase difference over the frequency range from 1 mHz to 1 Hz. Such a phase meter could also be used on Earth to perform similar measurements in laser metrology of moving bodies. To illustrate part of the principle of operation of the phase meter, the figure includes a simplified block diagram of a basic singlechannel digital receiver. The input RF signal is first fed to the input terminal of an analog-to-digital converter (ADC). To prevent aliasing errors in the ADC, the sampling rate must be at least twice the input signal frequency. The sampling rate of the ADC is governed by a sampling clock, which also drives a digital local oscillator (DLO), which is a direct digital frequency synthesizer. The DLO produces samples of sine and cosine signals at a programmed tuning frequency. The sine and cosine samples are mixed with (that is, multiplied by) the samples from the ADC, then low-pass filtered to obtain in-phase (I) and quadrature (Q) signal components. A digital signal processor (DSP) computes the ratio between the Q and I components, computes the phase of the RF signal (relative to that of the DLO signal) as the arctangent of this ratio, and then averages successive such phase values over a time interval specified by the user.

  10. Solar thermal energy receiver

    NASA Technical Reports Server (NTRS)

    Baker, Karl W. (Inventor); Dustin, Miles O. (Inventor)

    1992-01-01

    A plurality of heat pipes in a shell receive concentrated solar energy and transfer the energy to a heat activated system. To provide for even distribution of the energy despite uneven impingement of solar energy on the heat pipes, absence of solar energy at times, or failure of one or more of the heat pipes, energy storage means are disposed on the heat pipes which extend through a heat pipe thermal coupling means into the heat activated device. To enhance energy transfer to the heat activated device, the heat pipe coupling cavity means may be provided with extensions into the device. For use with a Stirling engine having passages for working gas, heat transfer members may be positioned to contact the gas and the heat pipes. The shell may be divided into sections by transverse walls. To prevent cavity working fluid from collecting in the extensions, a porous body is positioned in the cavity.

  11. Real-time software receiver

    NASA Technical Reports Server (NTRS)

    Ledvina, Brent M. (Inventor); Psiaki, Mark L. (Inventor); Powell, Steven P. (Inventor); Kintner, Jr., Paul M. (Inventor)

    2007-01-01

    A real-time software receiver that executes on a general purpose processor. The software receiver includes data acquisition and correlator modules that perform, in place of hardware correlation, baseband mixing and PRN code correlation using bit-wise parallelism.

  12. Real-time software receiver

    NASA Technical Reports Server (NTRS)

    Ledvina, Brent M. (Inventor); Psiaki, Mark L. (Inventor); Powell, Steven P. (Inventor); Kintner, Jr., Paul M. (Inventor)

    2006-01-01

    A real-time software receiver that executes on a general purpose processor. The software receiver includes data acquisition and correlator modules that perform, in place of hardware correlation, baseband mixing and PRN code correlation using bit-wise parallelism.

  13. High temperature solar thermal receiver

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A design concept for a high temperature solar thermal receiver to operate at 3 atmospheres pressure and 2500 F outlet was developed. The performance and complexity of windowed matrix, tube-header, and extended surface receivers were evaluated. The windowed matrix receiver proved to offer substantial cost and performance benefits. An efficient and cost effective hardware design was evaluated for a receiver which can be readily interfaced to fuel and chemical processes or to heat engines for power generation.

  14. High-temperature ceramic receivers

    SciTech Connect

    Jarvinen, P. O.

    1980-01-01

    An advanced ceramic dome cavity receiver is discussed which heats pressurized gas to temperatures above 1800/sup 0/F (1000/sup 0/C) for use in solar Brayton power systems of the dispersed receiver/dish or central receiver type. Optical, heat transfer, structural, and ceramic material design aspects of the receiver are reported and the development and experimental demonstration of a high-temperature seal between the pressurized gas and the high-temperature silicon carbide dome material is described.

  15. Bragg-cell receiver study

    NASA Technical Reports Server (NTRS)

    Wilson, Lonnie A.

    1987-01-01

    Bragg-cell receivers are employed in specialized Electronic Warfare (EW) applications for the measurement of frequency. Bragg-cell receiver characteristics are fully characterized for simple RF emitter signals. This receiver is early in its development cycle when compared to the IFM receiver. Functional mathematical models are derived and presented in this report for the Bragg-cell receiver. Theoretical analysis is presented and digital computer signal processing results are presented for the Bragg-cell receiver. Probability density function analysis are performed for output frequency. Probability density function distributions are observed to depart from assumed distributions for wideband and complex RF signals. This analysis is significant for high resolution and fine grain EW Bragg-cell receiver systems.

  16. Genetics Home Reference: paroxysmal nocturnal hemoglobinuria

    MedlinePlus

    ... at increased risk of developing cancer in blood-forming cells (leukemia). In some cases, people who have ... mutations of the PIGA gene occur in blood-forming cells called hematopoietic stem cells, which are found ...

  17. Low cost omega navigation receiver

    NASA Technical Reports Server (NTRS)

    Lilley, R. W.

    1974-01-01

    The development of a low cost Omega navigation receiver is discussed. Emphasis is placed on the completion and testing of a modular, multipurpose Omega receiver which utilizes a digital memory-aided, phase-locked loop to provide phase measurement data to a variety of applications interfaces. The functional units contained in the prototype device are described. The receiver is capable of receiving and storing phase measurements for up to eight Omega signals and computes two switch-selectable lines of position, displaying this navigation data in chart-recorded form.

  18. Receiver design and performance characteristics

    NASA Technical Reports Server (NTRS)

    Simon, M. K.; Yuen, J. H.

    1982-01-01

    The basic design, principles of operation, and characteristics of deep space communications receivers are examined. In particular, the basic fundamentals of phase-locked loop and Costas loop receivers used for synchronization, tracking, and demodulation of phase-coherent signals in residual carrier and suppressed carrier systems are addressed.

  19. Receiver design and performance characteristics

    NASA Astrophysics Data System (ADS)

    Simon, M. K.; Yuen, J. H.

    1982-07-01

    The basic design, principles of operation, and characteristics of deep space communications receivers are examined. In particular, the basic fundamentals of phase-locked loop and Costas loop receivers used for synchronization, tracking, and demodulation of phase-coherent signals in residual carrier and suppressed carrier systems are addressed.

  20. UWB delay and multiply receiver

    DOEpatents

    Dallum, Gregory E.; Pratt, Garth C.; Haugen, Peter C.; Romero, Carlos E.

    2013-09-10

    An ultra-wideband (UWB) delay and multiply receiver is formed of a receive antenna; a variable gain attenuator connected to the receive antenna; a signal splitter connected to the variable gain attenuator; a multiplier having one input connected to an undelayed signal from the signal splitter and another input connected to a delayed signal from the signal splitter, the delay between the splitter signals being equal to the spacing between pulses from a transmitter whose pulses are being received by the receive antenna; a peak detection circuit connected to the output of the multiplier and connected to the variable gain attenuator to control the variable gain attenuator to maintain a constant amplitude output from the multiplier; and a digital output circuit connected to the output of the multiplier.

  1. Noise Stability of SIS Receivers

    NASA Astrophysics Data System (ADS)

    Kooi, J. W.; Chattopadhyay, G.; Thielman, M.; Phillips, T. G.; Schieder, R.

    2000-05-01

    There is a strong interest in the submillimeter astronomy community to increase the IF bandwidth of SIS receivers in order to better facilitate broad spectral linewidth and continuum observations of extragalactic sources. However, with an increase in receiver IF bandwidth there is a decrease in the mixer stability. This in turn effects the integration efficiency and quality of the measurement. In order to better understand the noise mechanisms responsible for reducing the receiver stability, we employed a technique first described by D.W. Allan and later elaborated upon by Schieder et al. In this paper we address a variety of factors that degrade the noise stability of SIS receivers. The goal of this exercise is to make recommendations aimed at maximizing SIS receiver stability.

  2. Customizable Digital Receivers for Radar

    NASA Technical Reports Server (NTRS)

    Moller, Delwyn; Heavey, Brandon; Sadowy, Gregory

    2008-01-01

    Compact, highly customizable digital receivers are being developed for the system described in 'Radar Interferometer for Topographic Mapping of Glaciers and Ice Sheets' (NPO-43962), NASA Tech Briefs, Vol. 31, No. 7 (August 2007), page 72. The receivers are required to operate in unison, sampling radar returns received by the antenna elements in a digital beam-forming (DBF) mode. The design of these receivers could also be adapted to commercial radar systems. At the time of reporting the information for this article, there were no commercially available digital receivers capable of satisfying all of the operational requirements and compact enough to be mounted directly on the antenna elements. A provided figure depicts the overall system of which the digital receivers are parts. Each digital receiver includes an analog-to-digital converter (ADC), a demultiplexer (DMUX), and a field-programmable gate array (FPGA). The ADC effects 10-bit band-pass sampling of input signals having frequencies up to 3.5 GHz. The input samples are demultiplexed at a user-selectable rate of 1:2 or 1:4, then buffered in part of the FPGA that functions as a first-in/first-out (FIFO) memory. Another part of the FPGA serves as a controller for the ADC, DMUX, and FIFO memory and as an interface between (1) the rest of the receiver and (2) a front-panel data port (FPDP) bus, which is an industry-standard parallel data bus that has a high data-rate capability and multichannel configuration suitable for DBF. Still other parts of the FPGA in each receiver perform signal-processing functions. The digital receivers can be configured to operate in a stand-alone mode, or in a multichannel mode as needed for DBF. The customizability of the receiver makes it applicable to a broad range of system architectures. The capability for operation of receivers in either a stand-alone or a DBF mode enables the use of the receivers in an unprecedentedly wide variety of radar systems.

  3. Sensitivity of terahertz photonic receivers

    NASA Astrophysics Data System (ADS)

    Matsko, A. B.; Strekalov, D. V.; Yu, N.

    2008-04-01

    We theoretically discuss sensitivity limitations of a THz receiver which is based on up-conversion of the THz radiation into optical domain using high quality factor crystalline whispering gallery mode resonators. We show that the sensitivity of the receiver operating in the nonlinear regime approaches the sensitivity of an ideal THz photon counter. Thermal noise of the counter can be substantially reduced because of transparency of the nonlinear material in the THz frequency range. We also show that the density of power fluctuations of the receiver operating in the linear regime is given by the THz shot noise.

  4. Coe Receives 2007 Gilbert Award

    NASA Astrophysics Data System (ADS)

    Bogue, Scott W.; Coe, Robert S.

    2008-05-01

    Robert S. Coe received the 2007 William Gilbert Award at the 2007 AGU Fall Meeting in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  5. Stevenson received the Whipple award

    NASA Astrophysics Data System (ADS)

    Shoemaker, Eugene M.; Stevenson, David J.

    1996-02-01

    David J. Stevenson received the Whipple Award at the 1994 Spring Meeting in Baltimore. The award is given for outstanding scientific contributions to the field of planetology. The citation and Stevenson's response are given here.

  6. Streak camera receiver definition study

    NASA Technical Reports Server (NTRS)

    Johnson, C. B.; Hunkler, L. T., Sr.; Letzring, S. A.; Jaanimagi, P.

    1990-01-01

    Detailed streak camera definition studies were made as a first step toward full flight qualification of a dual channel picosecond resolution streak camera receiver for the Geoscience Laser Altimeter and Ranging System (GLRS). The streak camera receiver requirements are discussed as they pertain specifically to the GLRS system, and estimates of the characteristics of the streak camera are given, based upon existing and near-term technological capabilities. Important problem areas are highlighted, and possible corresponding solutions are discussed.

  7. Solar dynamic heat receiver technology

    NASA Technical Reports Server (NTRS)

    Sedgwick, Leigh M.

    1991-01-01

    A full-size, solar dynamic heat receiver was designed to meet the requirements specified for electrical power modules on the U.S. Space Station, Freedom. The heat receiver supplies thermal energy to power a heat engine in a closed Brayton cycle using a mixture of helium-xenon gas as the working fluid. The electrical power output of the engine, 25 kW, requires a 100 kW thermal input throughout a 90 minute orbit, including when the spacecraft is eclipsed for up to 36 minutes from the sun. The heat receiver employs an integral thermal energy storage system utilizing the latent heat available through the phase change of a high-temperature salt mixture. A near eutectic mixture of lithium fluoride and calcium difluoride is used as the phase change material. The salt is contained within a felt metal matrix which enhances heat transfer and controls the salt void distribution during solidification. Fabrication of the receiver is complete and it was delivered to NASA for verification testing in a simulated low-Earth-orbit environment. This document reviews the receiver design and describes its fabrication history. The major elements required to operate the receiver during testing are also described.

  8. UWB communication receiver feedback loop

    DOEpatents

    Spiridon, Alex; Benzel, Dave; Dowla, Farid U.; Nekoogar, Faranak; Rosenbury, Erwin T.

    2007-12-04

    A novel technique and structure that maximizes the extraction of information from reference pulses for UWB-TR receivers is introduced. The scheme efficiently processes an incoming signal to suppress different types of UWB as well as non-UWB interference prior to signal detection. Such a method and system adds a feedback loop mechanism to enhance the signal-to-noise ratio of reference pulses in a conventional TR receiver. Moreover, sampling the second order statistical function such as, for example, the autocorrelation function (ACF) of the received signal and matching it to the ACF samples of the original pulses for each transmitted bit provides a more robust UWB communications method and system in the presence of channel distortions.

  9. Central solar-energy receiver

    DOEpatents

    Not Available

    1981-10-27

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan is described. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  10. Organic Rankine cycle receiver development

    NASA Technical Reports Server (NTRS)

    Haskins, H. J.

    1981-01-01

    The selected receiver concept is a direct-heated, once-through, monotube boiler operated at supercritical pressure. The cavity is formed by a cylindrical copper shell and backwall, with stainless steel tubing brazed to the outside surface. This core is surrounded by lightweight refractory insulation, load-bearing struts, and an outer case. The aperture plate is made of copper to provide long life by conduction and reradiation of heat away from the aperture lip. The receiver thermal efficiency is estimated to be 97 percent at rated conditions (energy transferred to toluene divided by energy incident on aperture opening). Development of the core manufacturing and corrosion protection methods is complete.

  11. The GBT 4mm Receiver

    NASA Astrophysics Data System (ADS)

    Frayer, David T.; White, S.; Watts, G.; Stennes, M.; Maddalena, R. J.; Simon, R.; Pospieszalski, M.; Bryerton, E.

    2013-01-01

    The new 4mm receiver (67--93 GHz) for the Robert C. Byrd Green Bank Telescope (GBT) was built to take advantage of the improved surface accuracy of the dish. The low frequency end of the 3mm atmospheric window is not available with ALMA (<84 GHz), and the sensitivity of the GBT is better than any other facility within this band. We discuss the design and performance of this new receiver for the GBT, and highlight the science opportunities available with the instrument. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.

  12. Uncooled receivers for CO2 laser radiation

    NASA Astrophysics Data System (ADS)

    Granovskii, A. B.; Iakovlev, V. A.

    1986-01-01

    Published data on low-inertia, uncooled, single-element and matrix-type radiation receivers that have a high degree of reliability and are immune from interference from various external sources are systematically summarized. Three basic types of receivers are examined: photonic receivers, thermal receivers, and receivers based on wave interaction. Principal attention is given to the CO2 laser radiation receiver.

  13. STAR: SOFIA terahertz array receiver

    NASA Astrophysics Data System (ADS)

    Graf, Urs U.; Heyminck, Stefan; Rabanus, D.; Jacobs, Karl; Schieder, Rudolf T.; Stutzki, Juergen

    2003-02-01

    We present the concept for KOSMA's 16 element 1.9 THz heterodyne array STAR (SOFIA Terahertz Array Receiver) which is being developed for SOFIA. The instrument will consist of two interleaved sub-arrays of 8 pixels each. Together we will have a 4 × 4 pixel array with a beam spacing on the sky of approximately 1.5 times the beam size of 15 arcsec (FWHM). The receiver is mainly targeted at measuring the fine structure transition of ionized atomic carbon at 1.9 THz (158 microns). STAR's optics setup is modeled after the successful design used in KOSMA's SMART receiver. It will contain a K-mirror type beam rotator, a Martin-Puplett diplexer for LO coupling and an LO multiplexer using imaging Fourier gratings. Complete optical sub-assemblies will be machined monolithically as integrated optics units, to reduce the need for optical alignment. STAR will probably use waveguide mixers with diffusion cooled hot electron bolometers, which are being developed at KOSMA. The receiver backends will be KOSMA Array-AOSs. Local oscillator power will be provided by a backward wave oscillator (BWO), followed by a frequency tripler.

  14. Advances in SIS receiver technology

    NASA Technical Reports Server (NTRS)

    Frerking, M. A.

    1988-01-01

    Significant advances in SIS receiver technology since the last Asilomar meeting include: superconductor materials, integrated inductive tuning elements, and planar mounting structures. The effect of these advances is to push the upper frequency operating limit from about 600 to 1500 GHz, and to enhance the feasibility of focal plane arrays of heterodyne receivers. A fundamental high frequency operating limit of SIS mixers is set by the superconducting energy gap. A practical limitation for high frequency operation of SIS junctions is their parasitic capacitance and resistance. The performance of the mixer will be degraded by the Resistor-Capacitor rolloff. Several designs were reported for inductive elements integrated on the same substrate as the SIS junctions to tune out the bulk junction capacitance. Most millimeter SIS-based heterodyne receivers have used waveguide coupling structures. Technology has advanced to the state where programs that have a high probability of success can be defined to produce arrays of SIS receivers for frequencies as high as 1500 GHz.

  15. Microwave blackbodies for spaceborne receivers

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1985-01-01

    The properties of microwave blackbody targets are explained as they apply to the calibration of spaceborne receivers. Also described are several practicable, blackbody targets used to test and calibrate receivers in the laboratory and in the thermal vacuum chamber. Problems with the precision and the accuracy of blackbody targets, and blackbody target design concepts that overcome some of the accuracy limitations present in existing target designs, are presented. The principle of the Brewster angle blackbody target is described where the blackbody is applied as a fixed-temperature test target in the laboratory and as a variable-temperature target in the thermal vacuum chamber. The reflectivity of a Brewster angle target is measured in the laboratory. From this measurement, the emissivity of the target is calculated. Radiatively cooled thermal suspensions are discussed as the coolants of blackbody targets and waveguide terminations that function as calibration devices in spaceborne receivers. Examples are given for the design of radiatively cooled thermal suspensions. Corrugated-horn antennas used to observe the cosmic background and to provide a cold-calibration source for spaceborne receivers are described.

  16. Clark Receives Ocean Sciences Award

    NASA Astrophysics Data System (ADS)

    Roman, Michael R.; Clark, H. Lawrence

    2008-09-01

    H. Lawrence Clark received the 2008 Ocean Sciences Award at the 2008 Ocean Sciences Meeting, held 2-7 March 2008 in Orlando, Fla. The award is given in recognition of outstanding and long-standing service to the ocean sciences.

  17. RFID receiver apparatus and method

    DOEpatents

    Scott, Jeffrey Wayne

    2006-12-26

    An RFID backscatter interrogator for transmitting data to an RFID tag, generating a carrier for the tag, and receiving data from the tag modulated onto the carrier, the interrogator including a single grounded-coplanar wave-guide circuit board and at least one surface mount integrated circuit supported by the circuit board.

  18. Vergano Receives David Perlman Award

    NASA Astrophysics Data System (ADS)

    Kelly, Sue

    2006-08-01

    Dan Vergano received the Perlman Award at the Joint Assembly Honors Ceremony, whichwas held on 25 May 2006 in Baltimore, Md. Vergano was honored for `The Debate's over:Globe is warming,' which describes the linkages between the science of climate change andthe complexity of technical and economic decisions facing its mitigation.

  19. Receivers for modulated digital signals

    NASA Astrophysics Data System (ADS)

    Troendle, K.; Huber, J.

    The realization principles for coherent and incoherent receivers for modulated digital signal transmission are presented. From these principles, the digital amplitude, phase, and frequency modulation are treated. Expressions for the error probabilities in these systems are given, and their required bandwidths and noise sensitivities are compared. Principles of system realization for time-variant channels and methods of clock and carrier recovery are explained.

  20. Scintillation-Hardened GPS Receiver

    NASA Technical Reports Server (NTRS)

    Stephens, Donald R.

    2015-01-01

    CommLargo, Inc., has developed a scintillation-hardened Global Positioning System (GPS) receiver that improves reliability for low-orbit missions and complies with NASA's Space Telecommunications Radio System (STRS) architecture standards. A software-defined radio (SDR) implementation allows a single hardware element to function as either a conventional radio or as a GPS receiver, providing backup and redundancy for platforms such as the International Space Station (ISS) and high-value remote sensing platforms. The innovation's flexible SDR implementation reduces cost, weight, and power requirements. Scintillation hardening improves mission reliability and variability. In Phase I, CommLargo refactored an open-source GPS software package with Kalman filter-based tracking loops to improve performance during scintillation and also demonstrated improved navigation during a geomagnetic storm. In Phase II, the company generated a new field-programmable gate array (FPGA)-based GPS waveform to demonstrate on NASA's Space Communication and Navigation (SCaN) test bed.

  1. Femtosecond Photon-Counting Receiver

    NASA Technical Reports Server (NTRS)

    Krainak, Michael A.; Rambo, Timothy M.; Yang, Guangning; Lu, Wei; Numata, Kenji

    2016-01-01

    An optical correlation receiver is described that provides ultra-precise distance and/or time/pulse-width measurements even for weak (single photons) and short (femtosecond) optical signals. A new type of optical correlation receiver uses a fourth-order (intensity) interferometer to provide micron distance measurements even for weak (single photons) and short (femtosecond) optical signals. The optical correlator uses a low-noise-integrating detector that can resolve photon number. The correlation (range as a function of path delay) is calculated from the variance of the photon number of the difference of the optical signals on the two detectors. Our preliminary proof-of principle data (using a short-pulse diode laser transmitter) demonstrates tens of microns precision.

  2. SAW correlator spread spectrum receiver

    DOEpatents

    Brocato, Robert W

    2014-04-01

    A surface acoustic wave (SAW) correlator spread-spectrum (SS) receiver is disclosed which utilizes a first demodulation stage with a chip length n and a second demodulation stage with a chip length m to decode a transmitted SS signal having a code length l=n.times.m which can be very long (e.g. up to 2000 chips or more). The first demodulation stage utilizes a pair of SAW correlators which demodulate the SS signal to generate an appropriate code sequence at an intermediate frequency which can then be fed into the second demodulation stage which can be formed from another SAW correlator, or by a digital correlator. A compound SAW correlator comprising two input transducers and a single output transducer is also disclosed which can be used to form the SAW correlator SS receiver, or for use in processing long code length signals.

  3. Thompson receives 1994 Bowen award

    NASA Astrophysics Data System (ADS)

    Green, David H.; Thompson, Alan Bruce

    At the Spring Meeting in Baltimore, May 23, 1994, Alan Bruce Thompson of the Eidgenossiche Technische Hochschule, Zurich, received the 1994 N. L. Bowen Award of the Volcanology, Geochemsitry, and Petrology section, which is given for a single outstanding contribution to volcanology, geochemistry, or petrology made during the preceding 5 years. The award was presented by David H. Green of the Research School of Earth Sciences. The citation and response are given here.

  4. Digital-data receiver synchronization

    DOEpatents

    Smith, Stephen F.; Turner, Gary W.

    2005-08-02

    Digital-data receiver synchronization is provided with composite phase-frequency detectors, mutually cross-connected comparison feedback or both to provide robust reception of digital data signals. A single master clock can be used to provide frequency signals. Advantages can include fast lock-up time in moderately to severely noisy conditions, greater tolerance to noise and jitter when locked, and improved tolerance to clock asymmetries.

  5. Chip Advancer For GPS Receiver

    NASA Technical Reports Server (NTRS)

    Meehan, Thomas K.; Srinivasan, Jeffrey M.; Thomas, J. Brooks

    1989-01-01

    Instrument errors made negligible. For each integration interval, both delay and rate of change of delay initialized to small fraction of chip - for example, to order of 10 to the negative 7th power - thereby making feedback control and extraction of delay highly accurate and flexible. With appropriate selection of sampling rate relative to chip rate, commensurability errors reduced to extremely small levels. In Global Positioning System (GPS) receiver, pseudorandom code sequence generated by simple digital logic incorporating effects of time, delay, and rate of change of delay. Flexibility in starting time and sum interval very useful in aligning correlation interval with beginnings and endings of data bits.

  6. Stennis group receives NESC award

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

  7. Digital receiver study and implementation

    NASA Technical Reports Server (NTRS)

    Fogle, D. A.; Lee, G. M.; Massey, J. C.

    1972-01-01

    Computer software was developed which makes it possible to use any general purpose computer with A/D conversion capability as a PSK receiver for low data rate telemetry processing. Carrier tracking, bit synchronization, and matched filter detection are all performed digitally. To aid in the implementation of optimum computer processors, a study of general digital processing techniques was performed which emphasized various techniques for digitizing general analog systems. In particular, the phase-locked loop was extensively analyzed as a typical non-linear communication element. Bayesian estimation techniques for PSK demodulation were studied. A hardware implementation of the digital Costas loop was developed.

  8. Front end for GPS receivers

    NASA Technical Reports Server (NTRS)

    Thomas, Jr., Jess Brooks (Inventor)

    1999-01-01

    The front end in GPS receivers has the functions of amplifying, down-converting, filtering and sampling the received signals. In the preferred embodiment, only two operations, A/D conversion and a sum, bring the signal from RF to filtered quadrature baseband samples. After amplification and filtering at RF, the L1 and L2 signals are each sampled at RF at a high selected subharmonic rate. The subharmonic sample rates are approximately 900 MHz for L1 and 982 MHz for L2. With the selected subharmonic sampling, the A/D conversion effectively down-converts the signal from RF to quadrature components at baseband. The resulting sample streams for L1 and L2 are each reduced to a lower rate with a digital filter, which becomes a straight sum in the simplest embodiment. The frequency subsystem can be very simple, only requiring the generation of a single reference frequency (e.g. 20.46 MHz minus a small offset) and the simple multiplication of this reference up to the subharmonic sample rates for L1 and L2. The small offset in the reference frequency serves the dual purpose of providing an advantageous offset in the down-converted carrier frequency and in the final baseband sample rate.

  9. Reconfigurable optical transmitters and receivers

    NASA Astrophysics Data System (ADS)

    Freude, Wolfgang; Schmogrow, René; Hillerkuss, David; Meyer, Joachim; Dreschmann, Michael; Nebendahl, Bernd; Huebner, Michael; Becker, Juergen; Koos, Christian; Leuthold, Juerg

    2012-01-01

    Recent advances in electronic data processing allow constructing reconfigurable optical transmitters and receivers, where modulation formats and symbol rates are set by software-controlled field programmable gate arrays (FPGA). We report on such a real-time optical transmitter for 8 modulation formats, which can be swapped in 5 ns without data loss. With single-polarization 64QAM symbols generated at 28 GBd, we transmit data at 168 Gbit/s in real time. A similar arrangement defines a single-polarization orthogonal frequency division multiplexing (OFDM) transmitter for a data rate of 101.5 Gbit/s, where 58 subcarriers are encoded with 16QAM data. With a different software setup, the FPGA realizes an optical 56 Gbit/s transmitter for sinc-shaped so-called Nyquist pulses, the spectrum of which is rectangular having the minimum theoretically achievable bandwidth (suitable for Nyquist wavelength division multiplexing, N-WDM). For terabit OFDM reception, optical pre-processing is required to demultiplex high-bitrate signals down to lower-bitrate tributaries, which then can be processed electronically. We discuss a 10.8 Tbit/s (26 Tbit/s) receiver employing an all-optical fast Fourier transform to demultiplex 75 (325) optical subcarriers modulated with 16QAM-formated symbols at a rate of 18 GBd (10 GBd). Groups with any number of subcarriers can be selected with a simple hardware reconfiguration step.

  10. Sheeley Receives 2009 Hale Prize

    NASA Astrophysics Data System (ADS)

    Tretkoff, Ernie

    2009-05-01

    Neil Sheeley Jr., of the Space Science Division of the Naval Research Laboratory (NRL), has been awarded the 2009 George Ellery Hale Prize by the Solar Physics Division of the American Astronomical Society (AAS). The international award recognizes work in solar astronomy done over an extended period of time. Sheeley will receive the award in June at the AAS meeting in Pasadena, Calif. Sheeley is cited "for his continuing outstanding contributions to our understanding of the solar magnetic field, coronal holes, and coronal mass ejections. His wide-ranging observational and theoretical work has laid the foundation for much current research in solar and heliospheric physics, and continues to have important applications in space weather prediction."

  11. POVM Receivers for Quantum Cryptography

    NASA Astrophysics Data System (ADS)

    Brandt, H. E.

    1997-04-01

    Positive operator valued measures (POVMs) are finding increasing use in quantum cryptography.(A. Peres, Quantum Theory: Concepts and Methods, Kluwer Academic Publishers, Boston (1993).) I present quantum circuit analyses of two recently proposed (H. E. Brandt, J. M. Myers, and S. J. Lomonaco Jr., "New Results in Entangled Translucent Eavesdropping in Quantum Cryptography," in Photonic Quantum Computing, S. P. Hotaling and A. R. Pirich, Editors, Proc. SPIE 3076 (1997)) all-optical designs for POVM receivers to be used in conjunction with Bennett's B92 protocol for key distribution based on two photon polarization states. Expectation values for the POVM operators are calculated and shown to be faithfully realized by the POVM detectors.

  12. A cryogenic receiver for EPR.

    PubMed

    Narkowicz, R; Ogata, H; Reijerse, E; Suter, D

    2013-12-01

    Cryogenic probes have significantly increased the sensitivity of NMR. Here, we present a compact EPR receiver design capable of cryogenic operation. Compared to room temperature operation, it reduces the noise by a factor of ≈2.5. We discuss in detail the design and analyze the resulting noise performance. At low microwave power, the input noise density closely follows the emission of a cooled 50Ω resistor over the whole measurement range from 20K up to room temperature. To minimize the influence of the microwave source noise, we use high microwave efficiency (≈1.1-1.7mTW(-1/2)) planar microresonators. Their efficient conversion of microwave power to magnetic field permits EPR measurements with very low power levels, typically ranging from a few μW down to fractions of nW.

  13. Preamplifier Noise in VLF Receivers

    NASA Technical Reports Server (NTRS)

    Burhans, R. W.

    1978-01-01

    Noise specifications for junction field-effect transistors are presented in different ways depending on the particular semiconductor manufacturer. Arithmetic involved in converting these specifications to equivalent RMS noise in microvolts developed at the preamplifier input terminal is reviewed. These methods were useful for estimating the noise performance of high input impedance preamplifiers used with E-field antennas operating in the range of 1 KHz to 10 MHz. Both the JFET MPF-102 transistor and the COS/MOS CA3600 transistor array provided amplification for VLF receivers where the internally generated noise was well below the atmospheric noise level. The CA3600 transistor array provided better performance because of the more symmetrical complementary MOS transistor transfer characteristics than a single N-type biased JFET transistor. The CMOS amplifier resulted in self-compensating gain characteristics over a very wide temperature range from -55 to +125 C.

  14. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  15. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  16. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  17. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  18. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  19. Fluid absorption solar energy receiver

    NASA Technical Reports Server (NTRS)

    Bair, Edward J.

    1993-01-01

    A conventional solar dynamic system transmits solar energy to the flowing fluid of a thermodynamic cycle through structures which contain the gas and thermal energy storage material. Such a heat transfer mechanism dictates that the structure operate at a higher temperature than the fluid. This investigation reports on a fluid absorption receiver where only a part of the solar energy is transmitted to the structure. The other part is absorbed directly by the fluid. By proportioning these two heat transfer paths the energy to the structure can preheat the fluid, while the energy absorbed directly by the fluid raises the fluid to its final working temperature. The surface temperatures need not exceed the output temperature of the fluid. This makes the output temperature of the gas the maximum temperature in the system. The gas can have local maximum temperatures higher than the output working temperature. However local high temperatures are quickly equilibrated, and since the gas does not emit radiation, local high temperatures do not result in a radiative heat loss. Thermal radiation, thermal conductivity, and heat exchange with the gas all help equilibrate the surface temperature.

  20. Recent developments in superconducting receivers

    SciTech Connect

    Richards, P.L.

    1990-09-01

    A description is given of recent work at Berkeley on superconducting mixers and detectors for infrared and millimeter wavelengths. The first report is a review article which summarizes the status of development of superconducting components for infrared and millimeter wave receivers. The next report describes accurate measurements and also theoretical modeling of an SIS quasiparticle waveguide mixer for W-band which uses very high quality Ta junctions. The best mixer noise is only 1.3 times the quantum limit. Both the mixer gain and the noise are in quantitative agreement with the quantum theory. Next, a report is given on measurements and theoretical modeling of the absorptivity (surface resistance) of high quality epitaxial films of the high {Tc} superconductor YBCO from 750 GHz to 21 THz. Finally, there are reports on the design and experimental performance of two different types of high {Tc} bolometric detectors. One is a conventional bolometer with a gold-black absorber. The other is an antenna coupled microbolometer.

  1. Lunar Receiving Laboratory Project History

    NASA Technical Reports Server (NTRS)

    Mangus, Susan; Larsen, William

    2004-01-01

    As early as 1959, the Working Group on Lunar Exploration within NASA advocated that 'one of the prime objectives of the first lunar landing mission should be the collection of samples for return to Earth, where they could be subjected to detailed study and analysis.' Within NASA, neither this group nor any other scientists working with the Agency were concerned about back contamination issues. Outside of NASA, back contamination concerns had been raised as early as 1960. Although NASA did not seem to pay any attention to the concerns at that time, the scientific community continued to be interested in the topic. In 1962 and again in 1963, as the Apollo Program loomed large, further discussions were held. These early discussions of back contamination did not make their way into NASA's administration, however, and when Manned Spacecraft Center personnel began to articulate early concepts for the Lunar Receiving Laboratory (LRL), the back contamination issue was not considered. Once this concern became a major focus, however, the LRL's development became increasingly complex. This is the history of that development.

  2. Thermal resistance model for CSP central receivers

    NASA Astrophysics Data System (ADS)

    de Meyer, O. A. J.; Dinter, F.; Govender, S.

    2016-05-01

    The receiver design and heliostat field aiming strategy play a vital role in the heat transfer efficiency of the receiver. In molten salt external receivers, the common operating temperature of the heat transfer fluid or molten salt ranges between 285°C to 565°C. The optimum output temperature of 565°C is achieved by adjusting the mass flow rate of the molten salt through the receiver. The reflected solar radiation onto the receiver contributes to the temperature rise in the molten salt by means of heat transfer. By investigating published work on molten salt external receiver operating temperatures, corresponding receiver tube surface temperatures and heat losses, a model has been developed to obtain a detailed thermographic representation of the receiver. The steady state model uses a receiver flux map as input to determine: i) heat transfer fluid mass flow rate through the receiver to obtain the desired molten salt output temperature of 565°C, ii) receiver surface temperatures iii) receiver tube temperatures iv) receiver efficiency v) pressure drop across the receiver and vi) corresponding tube strain per panel.

  3. Percentage of Surgical Patients Receiving Recommended Care

    MedlinePlus

    ... Recommended Care Percentage of Surgical Patients Receiving Recommended Care This is a composite measure based on individual ... Age Group Percentage of Surgical Patients Receiving Recommended Care by Age Group uzrc-9bvr Download these data » ...

  4. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Irwin, S. H.; NELSON; Roleyni, G.

    1977-01-01

    Optimal design studies of MLS angle-receivers and a theoretical design-study of MLS DME-receivers are reported. The angle-receiver results include an integration of the scan data processor and tracking filter components of the optimal receiver into a unified structure. An extensive simulation study comparing the performance of the optimal and threshold receivers in a wide variety of representative dynamical interference environments was made. The optimal receiver was generally superior. A simulation of the performance of the threshold and delay-and-compare receivers in various signal environments was performed. An analysis of combined errors due to lateral reflections from vertical structures with small differential path delays, specular ground reflections with neglible differential path delays, and thermal noise in the receivers is provided.

  5. The First Six ALMA Band 10 Receivers

    NASA Astrophysics Data System (ADS)

    Fujii, Y.; Gonzalez, A.; Kroug, M.; Kaneko, K.; Miyachi, A.; Yokoshima, T.; Kuroiwa, K.; Ogawa, H.; Makise, K.; Wang, Z.; Uzawa, Y.

    2013-01-01

    The first six Atacama Large Millimeter/submillimeter Array (ALMA) Band 10 (787-950 GHz) receivers have been developed and characterized during the receiver preproduction phase. State-of-the-art measurement systems at THz frequencies have been implemented and successfully used to measure the performance of the first six receivers. Extensive tests ranging from receiver sensitivity and stability to optical aperture efficiency on the secondary antenna have been performed. Performance of all six receivers is well within the stringent ALMA requirements. Moreover, our extensive tests have shown that there are no big performance differences between receivers. These results indicate that the ALMA Band 10 receiver is ready for the production phase, during which an additional 67 receivers will be produced and characterized.

  6. High speed receiver for capsule endoscope.

    PubMed

    Woo, S H; Yoon, K W; Moon, Y K; Lee, J H; Park, H J; Kim, T W; Choi, H C; Won, C H; Cho, J H

    2010-10-01

    In this study, a high-speed receiver for a capsule endoscope was proposed and implemented. The proposed receiver could receive 20 Mbps data that was sufficient to receive images with a higher resolution than conventional receivers. The receiver used a 1.2 GHz band to receive radio frequency (RF) signal, and demodulated the signal to an intermediate frequency (IF) stage (150 MHz). The demodulated signal was amplified, filtered, and under-sampled by a high-speed analog-to-digital converter (ADC). In order to decode the under-sampled data in real time, a simple frequency detection algorithm was selected and was implemented by using a FPGA. The implemented system could receive 20 Mbps data.

  7. Trough Receiver Heat Loss Testing (Presentation)

    SciTech Connect

    Lewandowski, A.; Feik, C.; Hansen, R.; Phillips, S.; Bingham, C.; Netter, J.; Forristal, R.; Burkholder, F.; Meglan, B.; Wolfrum, E.

    2006-02-01

    This presentation describes the design, fabrication, and qualification of an experimental capability for thermal loss testing of full-size trough receiver elements; and the testing on a variety of receivers.

  8. How To Improve You Shipping and Receiving.

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2001-01-01

    Discusses how two universities improved their shipping and receiving operations and cut costs. Examples from the University of Texas at Dallas and John Hopkins University, Baltimore, Maryland, illustrate how they established greater shipping and receiving department efficiencies. (GR)

  9. Telemetry Tests Of The Advanced Receiver II

    NASA Technical Reports Server (NTRS)

    Hinedi, Sami M.; Bevan, Roland P.; Marina, Miguel

    1993-01-01

    Report describes telemetry tests of Advanced Receiver II (ARX-II): digital radio receiving subsystem operating on intermediate-frequency output of another receiving subsystem called "multimission receiver" (MMR), detecting carrier, subcarrier, and data-symbol signals transmitted by spacecraft, and extracts Doppler information from signals. Analysis of data shows performance of MMR/ARX-II system comparable and sometimes superior to performances of Blk-III/BPA and Blk-III/SDA/SSA systems.

  10. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  11. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  12. Battle Keeps Solar Energy in Receiver

    NASA Technical Reports Server (NTRS)

    Mcdougal, A. R.; Hale, R. R.

    1982-01-01

    Mirror structure in solar concentrator reduces heat loss by reflection and reradiation. Baffle reflects entering rays back and forth in solar-concentrator receiver until they reach heat exchanger. Similarly, infrared energy reradiated by heat exchanger is prevented from leaving receiver. Surfaces of baffle and inside wall of receiver are polished and highly reflective at solar and infrared wavelengths.

  13. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Receiver. 80.1013 Section 80.1013 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be...

  14. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  15. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Television receivers. 1020.10 Section 1020.10...

  16. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Television receivers. 1020.10 Section 1020.10...

  17. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Television receivers. 1020.10 Section 1020.10...

  18. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  19. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  20. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  1. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  2. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  3. 49 CFR 236.730 - Coil, receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Coil, receiver. 236.730 Section 236.730 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Coil, receiver. Concentric layers of insulated wire wound around the core of a receiver of an...

  4. 49 CFR 236.730 - Coil, receiver.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Coil, receiver. 236.730 Section 236.730 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Coil, receiver. Concentric layers of insulated wire wound around the core of a receiver of an...

  5. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Receiver. 80.1013 Section 80.1013 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be...

  6. A zero-power radio receiver.

    SciTech Connect

    Brocato, Robert Wesley

    2004-09-01

    This report describes both a general methodology and some specific examples of passive radio receivers. A passive radio receiver uses no direct electrical power but makes sole use of the power available in the radio spectrum. These radio receivers are suitable as low data-rate receivers or passive alerting devices for standard, high power radio receivers. Some zero-power radio architectures exhibit significant improvements in range with the addition of very low power amplifiers or signal processing electronics. These ultra-low power radios are also discussed and compared to the purely zero-power approaches.

  7. More Efficient Solar Thermal-Energy Receiver

    NASA Technical Reports Server (NTRS)

    Dustin, M. O.

    1987-01-01

    Thermal stresses and reradiation reduced. Improved design for solar thermal-energy receiver overcomes three major deficiencies of solar dynamic receivers described in literature. Concentrator and receiver part of solar-thermal-energy system. Receiver divided into radiation section and storage section. Concentrated solar radiation falls on boiling ends of heat pipes, which transmit heat to thermal-energy-storage medium. Receiver used in number of applications to produce thermal energy directly for use or to store thermal energy for subsequent use in heat engine.

  8. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III

    1979-01-01

    The angle tracking problems in microwave landing system receivers along with a receiver design capable of optimal performance in the multipath environments found in air terminal areas were studied. Included were various theoretical and evaluative studies like: (1) signal model development; (2) derivation of optimal receiver structures; and (3) development and use of computer simulations for receiver algorithm evaluation. The development of an experimental receiver for flight testing is presented. An overview of the work and summary of principal results and conclusions are reported.

  9. A minimalist approach to receiver architecture

    NASA Technical Reports Server (NTRS)

    Collins, O.

    1991-01-01

    New signal processing techniques are described for Deep Space Network radios and a proposed receiver architecture is presented, as well as experimental results on this new receiver's analog front end. The receiver's design employs direct downconversion rather than high speed digitization, and it is just as suitable for use as a space based probe relay receiver as it is for installation at a ground antenna. The advantages of having an inexpensive, shoe box size receiver, which could be carried around to antennas of opportunity, used for spacecraft testing or installed in the base of every antenna in a large array are the force behind this project.

  10. Integration Window Position Estimation in TR Receivers

    SciTech Connect

    Nekoogar, F; Dowla, F; Spiridon, A

    2005-03-15

    Transmitted-reference (TR) receivers avoid the stringent synchronization requirements that exist in conventional pulse detection schemes. However, the performance of such receivers is highly sensitive to precise timing acquisition and tracking as well as the length of their integration window. This window in TR receivers defines the limits of the finite integrator prior to the final decision making block. In this paper, we propose a novel technique that allows us to extract the timing information of the integration window very accurately in UWB-TR receivers in the presence of channel noise. The principles of the method are presented and the BER performance of a modified UWB-TR receiver is investigated by computer simulation. Our studies show that the proposed estimation technique adds value to the conventional TR receiver structure with modest increase in complexity.

  11. RF subsystem design for microwave communication receivers

    NASA Astrophysics Data System (ADS)

    Bickford, W. J.; Brodsky, W. G.

    A system review of the RF subsystems of (IFF) transponders, tropscatter receivers and SATCOM receivers is presented. The quantity potential for S-band and X-band IFF transponders establishes a baseline requirement. From this, the feasibility of a common design for these and other receivers is evaluated. Goals are established for a GaAs MMIC (monolithic microwave integrated circuit) device and related local oscillator preselector and self-test components.

  12. Absolute flux density calibrations: Receiver saturation effects

    NASA Technical Reports Server (NTRS)

    Freiley, A. J.; Ohlson, J. E.; Seidel, B. L.

    1978-01-01

    The effect of receiver saturation was examined for a total power radiometer which uses an ambient load for calibration. Extension to other calibration schemes is indicated. The analysis shows that a monotonic receiver saturation characteristic could cause either positive or negative measurement errors, with polarity depending upon operating conditions. A realistic model of the receiver was made by using a linear-cubic voltage transfer characteristic. The evaluation of measurement error for this model provided a means for correcting radio source measurements.

  13. Costas loop analysis for coherent optical receivers

    NASA Astrophysics Data System (ADS)

    Hodgkinson, T. G.

    1986-03-01

    A homodyne Costas loop receiver is analyzed taking both shot and laser phase noise sources into acount. The reciever performance is compared with that of a heterodyne receiver using an electrical Costas loop and that of a coherent receiver using a pilot carrier phase-locked loop. It is shown that, to avoid large performance penalties, beat linewidth to bit-rate ratios smaller than 0.05 percent and 0.5 percent are needed for PSK homodyne and heterodyne systems, respectively.

  14. Ceramic high temperature receiver design and tests

    NASA Technical Reports Server (NTRS)

    Davis, S. B.

    1982-01-01

    The High Temperature Solar Thermal Receiver, which was tested a Edwards AFB, CA during the winter of 1980-1981, evolved from technologies developed over a five year period of work. This receiver was tested at the Army Solar Furnace at White Sands, NM in 1976. The receiver, was tested successfully at 1768 deg F and showed thermal efficiencies of 85%. The results were sufficiently promising to lead ERDA to fund our development and test of a 250 kW receiver to measure the efficiency of an open cavity receiver atop a central tower of a heliostat field. This receiver was required to be design scalable to 10, 50, and 100 MW-electric sizes to show applicability to central power tower receivers. That receiver employed rectagular silicon carbide panels and vertical stanchions to achieve scalability. The construction was shown to be fully scalable; and the receiver was operated at temperatures up to 2000 deg F to achieve the performance goals of the experiment during tests at the GIT advanced components test facility during the fall of 1978.

  15. Ceramic high temperature receiver design and tests

    SciTech Connect

    Davis, S.B.

    1982-07-01

    The High Temperature Solar Thermal Receiver, which was tested a Edwards AFB, CA during the winter of 1980-1981, evolved from technologies developed over a five year period of work. This receiver was tested at the Army Solar Furnace at White Sands, NM in 1976. The receiver, was tested successfully at 1768 deg F and showed thermal efficiencies of 85%. The results were sufficiently promising to lead ERDA to fund our development and test of a 250 kW receiver to measure the efficiency of an open cavity receiver atop a central tower of a heliostat field. This receiver was required to be design scalable to 10, 50, and 100 MW-electric sizes to show applicability to central power tower receivers. That receiver employed rectangular silicon carbide panels and vertical stanchions to achieve scalability. The construction was shown to be fully scalable, and the receiver was operated at temperatures up to 2000 deg F to achieve the performance goals of the experiment during tests at the GIT advanced components test facility during the fall of 1978.

  16. False lock performance of quadriphase receivers

    NASA Technical Reports Server (NTRS)

    Simon, M. K.

    1979-01-01

    Quadriphase receivers, like biphase receivers, have the ability to false lock on a sideband on the data modulation. The theory associated with this phenomenon for receivers of binary phase-shift-keying (BPSK), using Costas loop demodulation, has recently been documented in the literature. This paper considers the corresponding theory for receivers of balanced quadriphase-shift-keying (QPSK) employing a quadriphase Costas loop (or equivalent fourth-power loop) for demodulation. Specific closed form expressions for false lock performance are developed and numerically evaluated for the particular case of single pole arm filters and an NRZ data format for each of the two statistically independent quadrature modulations.

  17. Nursing process approach improves receivables management.

    PubMed

    Dias, K; Stockamp, D

    1992-09-01

    The "nursing process" is a systematic decision-making approach to problem solving based on open-system theory. This theory assumes that there is an on-going interchange between all system components. Components cannot be viewed in isolation, because decisions regarding one component will affect other components. Receivables management is similar to the nursing process, in that it involves constant diagnosis, assessment, and intervention in the work in process during all phases of the receivables cycle. In experiments that applied the nursing process concept to the management of accounts receivable in several hospitals, gross days in accounts receivable were reduced and cash flow was increased. PMID:10145682

  18. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed...

  19. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  20. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  1. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  2. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  3. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  4. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III; Irwin, S. H.; Padgett, J. E.

    1975-01-01

    A receiver is designed for aircraft (A/C), which, as a component of the proposed Microwave Landing System (MLS), is capable of optimal performance in the multipath environments found in air terminal areas. Topics discussed include: the angle-tracking problem of the MLS receiver; signal modeling; preliminary approaches to optimal design; suboptimal design; and simulation study.

  5. Liquid cooled fiber thermal radiation receiver

    DOEpatents

    Butler, Barry L.

    1987-01-01

    A radiation-to-thermal receiver apparatus for collecting radiation and converting it to thermal energy is disclosed. The invention includes a fibrous mat material which captures radiation striking the receiver. Captured radiation is removed from the fibrous mat material by a transparent fluid within which the material is bathed.

  6. Liquid cooled fiber thermal radiation receiver

    DOEpatents

    Butler, B.L.

    1985-03-29

    A radiation-to-thermal receiver apparatus for collecting radiation and converting it to thermal energy is disclosed. The invention includes a fibrous mat material which captures radiation striking the receiver. Captured radiation is removed from the fibrous mat material by a transparent fluid within which the material is bathed.

  7. Heat-Energy Analysis for Solar Receivers

    NASA Technical Reports Server (NTRS)

    Lansing, F. L.

    1982-01-01

    Heat-energy analysis program (HEAP) solves general heat-transfer problems, with some specific features that are "custom made" for analyzing solar receivers. Can be utilized not only to predict receiver performance under varying solar flux, ambient temperature and local heat-transfer rates but also to detect locations of hotspots and metallurgical difficulties and to predict performance sensitivity of neighboring component parameters.

  8. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  9. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  10. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  11. 17 CFR 256.143 - Accounts receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Accounts receivable. 256.143... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.143 Accounts receivable. This account...

  12. 17 CFR 256.143 - Accounts receivable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Accounts receivable. 256.143... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.143 Accounts receivable. This account...

  13. 29 CFR 1910.169 - Air receivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Compressed Gas and Compressed Air Equipment § 1910.169 Air receivers. (a) General requirements—(1) Application. This section applies to compressed air receivers, and other equipment used in providing and utilizing compressed air for performing operations such as...

  14. Advanced heat receiver conceptual design study

    NASA Technical Reports Server (NTRS)

    Kesseli, James; Saunders, Roger; Batchelder, Gary

    1988-01-01

    Solar Dynamic space power systems are candidate electrical power generating systems for future NASA missions. One of the key components of the solar dynamic power system is the solar receiver/thermal energy storage (TES) subsystem. Receiver development was conducted by NASA in the late 1960's and since then a very limited amount of work has been done in this area. Consequently the state of the art (SOA) receivers designed for the IOC space station are large and massive. The objective of the Advanced Heat Receiver Conceptual Design Study is to conceive and analyze advanced high temperature solar dynamic Brayton and Stirling receivers. The goal is to generate innovative receiver concepts that are half of the mass, smaller, and more efficient than the SOA. It is also necessary that these innovative receivers offer ease of manufacturing, less structural complexity and fewer thermal stress problems. Advanced Brayton and Stirling receiver storage units are proposed and analyzed in this study which can potentially meet these goals.

  15. 47 CFR 32.1170 - Receivables.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... enable the company to make the following analysis: (1) Amounts due from customers who are receiving... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.1170 Receivables. (a) This account shall include all amounts due from customers for services rendered or billed and...

  16. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  17. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  18. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  19. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  20. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  1. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... transportation applications as railways, vehicles or cranes. (b) Gauges and valves. (1) Air receivers shall be equipped with indicating pressure gauges and spring-loaded safety valves. Safety valves shall prevent receiver pressure from exceeding 110 percent of the maximum allowable working pressure. (2) No other...

  2. OMEGA timing receiver, design and system test

    NASA Technical Reports Server (NTRS)

    Wilson, J. J.; Britt, J. E.; Chi, A.

    1972-01-01

    The design of a two frequency OMEGA Timing Receiver is discussed. The receiver tracks the arrival time of the signals by precise phase matching at the receiving antenna. Provision is made for inserting a propagation delay correction for each signal path. Time is measured as the difference between the zero crossing coincidence of the corrected signals and the local time. This number is displayed on the front panel in microseconds. The receiver can also function as a precise phase tracking receiver for collection of propagation data essential to augmenting the propagation corrections. All phase and time information is made available in a BCD format for flexibility in interfacing with other equipment. Results of preliminary tests using experimental transmissions are given. Preliminary results indicate time may be transferred by this technique to an accuracy of a few microseconds.

  3. EHF low-noise FET receiver

    NASA Technical Reports Server (NTRS)

    Schellenberg, J. M.; Watkins, E. T.

    1983-01-01

    Extremely high frequency (EHF) receivers for military and NASA programs must be small, lightweight, and highly reliable. In connection with recent advances in the development of mm-wave FET devices and circuits, a basis has been obtained for the eventual replacement of diode mixer front-ends by FET preamplifiers in receivers up to 94 GHz. By placing a low noise amplifier in front of the mixer it is possible to achieve a lower system noise figure than that found in conventional mm-wave receivers. A broader bandwidth can also be provided. Attention is given to the receiver configuration, a low noise FET amplifier, an image rejection filter, a dual-gate FET mixer, a FET local oscillator, and a FET receiver.

  4. Temperature influences in receiver clock modelling

    NASA Astrophysics Data System (ADS)

    Wang, Kan; Meindl, Michael; Rothacher, Markus; Schoenemann, Erik; Enderle, Werner

    2016-04-01

    In Precise Point Positioning (PPP), hardware delays at the receiver site (receiver, cables, antenna, …) are always difficult to be separated from the estimated receiver clock parameters. As a result, they are partially or fully contained in the estimated "apparent" clocks and will influence the deterministic and stochastic modelling of the receiver clock behaviour. In this contribution, using three years of data, the receiver clock corrections of a set of high-precision Hydrogen Masers (H-Masers) connected to stations of the ESA/ESOC network and the International GNSS Service (IGS) are firstly characterized concerning clock offsets, drifts, modified Allan deviations and stochastic parameters. In a second step, the apparent behaviour of the clocks is modelled with the help of a low-order polynomial and a known temperature coefficient (Weinbach, 2013). The correlations between the temperature and the hardware delays generated by different types of antennae are then analysed looking at daily, 3-day and weekly time intervals. The outcome of these analyses is crucial, if we intend to model the receiver clocks in the ground station network to improve the estimation of station-related parameters like coordinates, troposphere zenith delays and ambiguities. References: Weinbach, U. (2013) Feasibility and impact of receiver clock modeling in precise GPS data analysis. Dissertation, Leibniz Universität Hannover, Germany.

  5. Terahertz Array Receivers with Integrated Antennas

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam; Llombart, Nuria; Lee, Choonsup; Jung, Cecile; Lin, Robert; Cooper, Ken B.; Reck, Theodore; Siles, Jose; Schlecht, Erich; Peralta, Alessandro; Thomas, Bertrand; Mehdi, Imran

    2011-01-01

    Highly sensitive terahertz heterodyne receivers have been mostly single-pixel. However, now there is a real need of multi-pixel array receivers at these frequencies driven by the science and instrument requirements. In this paper we explore various receiver font-end and antenna architectures for use in multi-pixel integrated arrays at terahertz frequencies. Development of wafer-level integrated terahertz receiver front-end by using advanced semiconductor fabrication technologies has progressed very well over the past few years. Novel stacking of micro-machined silicon wafers which allows for the 3-dimensional integration of various terahertz receiver components in extremely small packages has made it possible to design multi-pixel heterodyne arrays. One of the critical technologies to achieve fully integrated system is the antenna arrays compatible with the receiver array architecture. In this paper we explore different receiver and antenna architectures for multi-pixel heterodyne and direct detector arrays for various applications such as multi-pixel high resolution spectrometer and imaging radar at terahertz frequencies.

  6. The Los Alamos beacon receiver array

    SciTech Connect

    Carlos, R.C.; Massey, R.S. )

    1994-07-01

    The authors are interested in studying both the natural background of acoustic and acoustic-gravity waves, for which the sources are not generally known, as well as waves produced by known sources such as large explosions and launches of large rockets. The authors describe radio receivers that monitor transmissions from beacons on geosynchronous satellites. The receivers can detect perturbations of a 300--3,000 s period in the electron density integrated from beacon to receiver, for amplitudes as low as (1--2) [times] 10[sup 13] m[sup [minus]2]. Data are used in studies of atmospheric acoustic and acoustic-gravity waves.

  7. Global Positioning System receiver evaluation results

    SciTech Connect

    Byrne, R.H.

    1993-09-01

    A Sandia project currently uses an outdated Magnavox 6400 Global Positioning System (GPS) receiver as the core of its navigation system. The goal of this study was to analyze the performance of the current GPS receiver compared to newer, less expensive models and to make recommendations on how to improve the performance of the overall navigation system. This paper discusses the test methodology used to experimentally analyze the performance of different GPS receivers, the test results, and recommendations on how an upgrade should proceed. Appendices contain detailed information regarding the raw data, test hardware, and test software.

  8. 47 CFR 80.858 - Radiotelephone receiver.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... frequencies authorized pursuant to § 80.855(a). (b) One or more loudspeakers capable of being used to maintain... receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a signal-to-noise...

  9. 47 CFR 80.913 - Radiotelephone receivers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... public coast stations serving the area in which the vessel is navigated. (d) One or more loudspeakers... at the receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a...

  10. 47 CFR 80.913 - Radiotelephone receivers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... public coast stations serving the area in which the vessel is navigated. (d) One or more loudspeakers... at the receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a...

  11. 47 CFR 80.858 - Radiotelephone receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... frequencies authorized pursuant to § 80.855(a). (b) One or more loudspeakers capable of being used to maintain... receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a signal-to-noise...

  12. 47 CFR 80.858 - Radiotelephone receiver.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... frequencies authorized pursuant to § 80.855(a). (b) One or more loudspeakers capable of being used to maintain... receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a signal-to-noise...

  13. 47 CFR 80.913 - Radiotelephone receivers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... public coast stations serving the area in which the vessel is navigated. (d) One or more loudspeakers... at the receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a...

  14. 47 CFR 80.858 - Radiotelephone receiver.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... frequencies authorized pursuant to § 80.855(a). (b) One or more loudspeakers capable of being used to maintain... receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a signal-to-noise...

  15. 47 CFR 80.913 - Radiotelephone receivers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... public coast stations serving the area in which the vessel is navigated. (d) One or more loudspeakers... at the receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a...

  16. 47 CFR 80.913 - Radiotelephone receivers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... public coast stations serving the area in which the vessel is navigated. (d) One or more loudspeakers... at the receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a...

  17. 47 CFR 80.858 - Radiotelephone receiver.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... frequencies authorized pursuant to § 80.855(a). (b) One or more loudspeakers capable of being used to maintain... receiver input to produce an audio output of 50 milliwatts to the loudspeaker with a signal-to-noise...

  18. Collector/Receiver Characterization (Fact Sheet)

    SciTech Connect

    Not Available

    2010-08-01

    Fact sheet describing NREL CSP Program capabilities for collector/receiver characterization: determining optical efficiency, measuring heat loss, developing and testing concentrators, concentrating the sun's power, and optically characterizing CSP plants.

  19. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... components of the receiver except that portion of the neck and socket of the cathode-ray tube which normally... of a circuit or shield component. The warning label shall include the specification of operating...

  20. First Public Library Satellite Receiver System.

    ERIC Educational Resources Information Center

    Donaldson, Marion F.

    1982-01-01

    Description of video services at Lake County Public Library, Indiana, highlights the installation of a satellite receiver system and notes funding and justification, components of a satellite system, decisions and sources of assistance, programming available, and future considerations. (EJS)

  1. Digital Signal Processing Based Biotelemetry Receivers

    NASA Technical Reports Server (NTRS)

    Singh, Avtar; Hines, John; Somps, Chris

    1997-01-01

    This is an attempt to develop a biotelemetry receiver using digital signal processing technology and techniques. The receiver developed in this work is based on recovering signals that have been encoded using either Pulse Position Modulation (PPM) or Pulse Code Modulation (PCM) technique. A prototype has been developed using state-of-the-art digital signal processing technology. A Printed Circuit Board (PCB) is being developed based on the technique and technology described here. This board is intended to be used in the UCSF Fetal Monitoring system developed at NASA. The board is capable of handling a variety of PPM and PCM signals encoding signals such as ECG, temperature, and pressure. A signal processing program has also been developed to analyze the received ECG signal to determine heart rate. This system provides a base for using digital signal processing in biotelemetry receivers and other similar applications.

  2. A C-Band satellite receiver

    NASA Astrophysics Data System (ADS)

    Lupinetti, F.; Ingels, F.

    1985-12-01

    The design concept of a 24-channel C-band receiver for satellite TV signals is presented. The system comprises a low-noise amplifier, a 3.7-4.2-GHz/450-910-MHz block down converter, the receiver proper (a modified analog UNF tuner at IF = 45 MHz and a digital channel selector), and an RF modulator providing video and audio on channels 3 or 4. The operation of the receiver is described and illustrated with block diagrams and tables of specifications. A prototype receiver has been found to give good video quality and definition with clear 20-20,000-Hz audio when used with a 4-ft dish antenna.

  3. 49 CFR 236.788 - Receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.788 Receiver. A device on a locomotive, so placed that it is in position to be influenced inductively or actuated by...

  4. NASA Dryden Receives 'New' F-15Ds

    NASA Video Gallery

    NASA's Dryden Flight Research Center has received three F-15D Eagle aircraft from the U.S. Air Force for flight research and mission support duties. The demilitarized high-performance aircraft were...

  5. A 30 GHz monolithic receive module

    NASA Technical Reports Server (NTRS)

    Mondal, J.; Contolatis, T.; Geddes, J.; Bauhahn, P.; Sokolov, V.

    1990-01-01

    The technical achievements and deliveries made during the duration of the program to develop a 30 GHz monolithic receive module for communication feed array applications and to deliver submodules and 30 GHz monolithic receive modules for experimental evaluation are discussed. Key requirements include an overall receive module noise figure of 5 dB, a 30 dB RF-to-RF gain with six levels of intermediate gain control, a five bit phase shifter, and a maximum power consumption of 250 mW. In addition, the monolithic receive module design addresses a cost goal of less than one thousand dollars (1980 dollars) per module in unit buys of 5,000 or more, and a mechanical configuration that is applicable to a spaceborne phase array system. An additional task for the development and delivery of 32 GHz phase shifter integrated circuit (IC) for deep space communication is also described.

  6. High dynamic GPS receiver validation demonstration

    NASA Technical Reports Server (NTRS)

    Hurd, W. J.; Statman, J. I.; Vilnrotter, V. A.

    1985-01-01

    The Validation Demonstration establishes that the high dynamic Global Positioning System (GPS) receiver concept developed at JPL meets the dynamic tracking requirements for range instrumentation of missiles and drones. It was demonstrated that the receiver can track the pseudorange and pseudorange rate of vehicles with acceleration in excess of 100 g and jerk in excess of 100 g/s, dynamics ten times more severe than specified for conventional High Dynamic GPS receivers. These results and analytic extensions to a complete system configuration establish that all range instrumentation requirements can be met. The receiver can be implemented in the 100 cu in volume required by all missiles and drones, and is ideally suited for transdigitizer or translator applications.

  7. Stanley receives 2010 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Weiss, Benjamin P.

    2011-06-01

    Sabine Stanley received the William Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  8. Kirschvink receives 2011 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Weiss, Benjamin P.

    2012-04-01

    Joseph Kirschvink received the William Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  9. Kirschvink receives 2011 William Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Kirschvink, Joseph L.

    2012-04-01

    Joseph Kirschvink received the William Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  10. Dennis Kent Receives 2009 William Gilbert Award

    NASA Astrophysics Data System (ADS)

    Tauxe, Lisa; Kent, Dennis

    2010-06-01

    Dennis Kent received the William Gilbert Award at the 2009 AGU Fall Meeting, held 14-18 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  11. Lagroix Receives 2008 William Gilbert Award

    NASA Astrophysics Data System (ADS)

    Moskowitz, Bruce M.; Banerjee, Subir K.; Lagroix, France

    2009-04-01

    France Lagroix received the William Gilbert Award at the 2008 AGU Fall Meeting Honors Ceremony, held 17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  12. Stanley receives 2010 William Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Stanley, Sabine

    2011-06-01

    Sabine Stanley received the William Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  13. Go International! Build a Simplified Shortwave Receiver

    ERIC Educational Resources Information Center

    Homoly, Clarke

    2008-01-01

    This article presents a plan for building a shortwave receiver that is doable, educational and has reasonable performance. The project, says the author, can give students years of listening fun without a major financial investment. Potential project improvements are included.

  14. 47 CFR 32.1170 - Receivables.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.1170 Receivables. (a... of interest accrued to the date of the balance sheet on bonds, notes, and other commercial...

  15. Solar central receiver systems comparative economics

    SciTech Connect

    Eicker, P J

    1980-04-01

    Several major conceptual design studies of solar central receiver systems and components have been completed in the last year. The results of these studies are used to compare the projected cost of electric power generation using central receiver systems with that of more conventional power generation. The cost estimate for a molten salt central receiver system is given. Levelized busbar energy cost is shown as a function of annual capacity factor indicating the fraction of the cost due to each of the subsystems. The estimated levelized busbar energy cost for a central receiver (70 to 90 mills per kilowatt hour) is compared with the levelized busbar energy cost for a new coal fired Rankine cycle plant. Sensitivities to the initial cost of coal and the delta fuel escalation are shown. (WHK)

  16. Comparing Drug Use between Welfare-Receiving Arrestees and Non-Welfare-Receiving Arrestees.

    ERIC Educational Resources Information Center

    Yacoubian, George S., Jr.; Peters, Ronald J., Jr.; Urbach, Blake J.; Johnson, Regina J.

    2002-01-01

    Compares drug-positive rates between welfare-receiving arrestees, non-welfare receiving arrestees living below the poverty level, and non-welfare arrestees living above the poverty level. Welfare-receiving arrestees were more likely to be female, older, less educated, and to test positive for opiates and benzodiazepines than the other subgroups.…

  17. Flexible receiver adapter formal design review

    SciTech Connect

    Krieg, S.A.

    1995-06-13

    This memo summarizes the results of the Formal (90%) Design Review process and meetings held to evaluate the design of the Flexible Receiver Adapters, support platforms, and associated equipment. The equipment is part of the Flexible Receiver System used to remove, transport, and store long length contaminated equipment and components from both the double and single-shell underground storage tanks at the 200 area tank farms.

  18. Single-Receiver GPS Phase Bias Resolution

    NASA Technical Reports Server (NTRS)

    Bertiger, William I.; Haines, Bruce J.; Weiss, Jan P.; Harvey, Nathaniel E.

    2010-01-01

    Existing software has been modified to yield the benefits of integer fixed double-differenced GPS-phased ambiguities when processing data from a single GPS receiver with no access to any other GPS receiver data. When the double-differenced combination of phase biases can be fixed reliably, a significant improvement in solution accuracy is obtained. This innovation uses a large global set of GPS receivers (40 to 80 receivers) to solve for the GPS satellite orbits and clocks (along with any other parameters). In this process, integer ambiguities are fixed and information on the ambiguity constraints is saved. For each GPS transmitter/receiver pair, the process saves the arc start and stop times, the wide-lane average value for the arc, the standard deviation of the wide lane, and the dual-frequency phase bias after bias fixing for the arc. The second step of the process uses the orbit and clock information, the bias information from the global solution, and only data from the single receiver to resolve double-differenced phase combinations. It is called "resolved" instead of "fixed" because constraints are introduced into the problem with a finite data weight to better account for possible errors. A receiver in orbit has much shorter continuous passes of data than a receiver fixed to the Earth. The method has parameters to account for this. In particular, differences in drifting wide-lane values must be handled differently. The first step of the process is automated, using two JPL software sets, Longarc and Gipsy-Oasis. The resulting orbit/clock and bias information files are posted on anonymous ftp for use by any licensed Gipsy-Oasis user. The second step is implemented in the Gipsy-Oasis executable, gd2p.pl, which automates the entire process, including fetching the information from anonymous ftp

  19. A handbook for solar central receiver design

    SciTech Connect

    Falcone, P.K.

    1986-12-01

    This Handbook describes central receiver technology for solar thermal power plants. It contains a description and assessment of the major components in a central receiver system configured for utility scale production of electricity using Rankine-cycle steam turbines. It also describes procedures to size and optimize a plant and discussed examples from recent system analyses. Information concerning site selection criteria, cost estimation, construction, and operation and maintenance is also included, which should enable readers to perform design analyses for specific applications.

  20. Submillimeter-wave receivers - A status report

    NASA Technical Reports Server (NTRS)

    Wilson, W. J.

    1983-01-01

    A development status assessment is presented for the work of U.S. and Western European research groups on heterodyne sub-mm receivers in the 300-1000 GHz frequency range. The applications driving sub-mm receiver and local oscillator source technologies are radio astronomy, atmospheric measurements, plasma diagnostics, and laboratory spectroscopy. Progress is concentrated in two areas, cooled Schottky diode mixers and solid state local oscillators employing frequency multipliers.

  1. Adaptive Detector Arrays for Optical Communications Receivers

    NASA Technical Reports Server (NTRS)

    Vilnrotter, V.; Srinivasan, M.

    2000-01-01

    The structure of an optimal adaptive array receiver for ground-based optical communications is described and its performance investigated. Kolmogorov phase screen simulations are used to model the sample functions of the focal-plane signal distribution due to turbulence and to generate realistic spatial distributions of the received optical field. This novel array detector concept reduces interference from background radiation by effectively assigning higher confidence levels at each instant of time to those detector elements that contain significant signal energy and suppressing those that do not. A simpler suboptimum structure that replaces the continuous weighting function of the optimal receiver by a hard decision on the selection of the signal detector elements also is described and evaluated. Approximations and bounds to the error probability are derived and compared with the exact calculations and receiver simulation results. It is shown that, for photon-counting receivers observing Poisson-distributed signals, performance improvements of approximately 5 dB can be obtained over conventional single-detector photon-counting receivers, when operating in high background environments.

  2. Low-temperature volumetric receiver concept

    NASA Astrophysics Data System (ADS)

    Drost, M. K.

    1988-09-01

    This document describes an alternative solar central receiver concept that offers the potential for a substantial reduction in the cost of electrical energy. The concept consists of a low temperature volumetric receiver which supplies 1100 F air to a Kalina cycle heat engine. Hot air can also be supplied to a packed bed of Dresser basalt where the hot air is used to heat the bed. The thermal energy stored in the bed can be extracted and supplied to the Kalina cycle during periods of low insolation. Previous investigations of the volumetric receiver concentrated on high temperature applications. The results showed that the volumetric concept could be very efficient, but the receiver was expensive and there were significant technical problems. Areas of technical uncertainty included fiber durability, the feasibility of inducing a preswirl and cost effective applications. The use of the volumetric receiver to produce low temperature will avoid the problems identified in the high temperature studies. The attractiveness of the low temperature concept is enhanced by the availability of the Kalina cycle. This heat engine was developed as a bottoming cycle for Brayton and Rankine cycle power plants. The key feature of the Kalina cycle is its ability to efficiently utilize the energy in a relatively low temperature heat source. The combination of the low temperature volumetric receiver and the Kalina cycle is particularly interesting.

  3. Low-temperature volumetric receiver concept

    SciTech Connect

    Drost, M.K.

    1988-09-01

    This document describes an alternative solar central receiver concept that offers the potential for a substantial reduction in the cost of electrical energy. The concept consists of a low temperature volumetric receiver which supplies 1100/degree/F air to a Kalina cycle heat engine. Hot air can also be supplied to a packed bed of Dresser basalt where the hot air is used to heat the bed. The thermal energy stored in the bed can be extracted and supplied to the Kalina cycle during periods of low insolation. Previous investigations of the volumetric receiver concentrated on high temperature applications. The results showed that the volumetric concept could be very efficient, but the receiver was expensive and there were significant technical problems. Areas of technical uncertainty included fiber durability, the feasibility of inducing a preswirl and cost effective applications. The use of the volumetric receiver to produce low temperature will avoid the problems identified in the high temperature studies. The attractiveness of the low temperature concept is enhanced by the availability of the Kalina cycle. This heat engine was developed as a bottoming cycle for Brayton and Rankine cycle power plants. The key feature of the Kalina cycle is its ability to efficiently utilize the energy in a relatively low temperature heat source. The combination of the low temperature volumetric receiver and the Kalina cycle is particularly interesting. 7 refs., 2 figs., 3 tabs.

  4. Internal Film Receiver systems assessment study

    SciTech Connect

    Anderson, J.V.

    1988-03-01

    This report documents SERI's Internal Film Receiver (IFR) design study and system assessment effort; and it compares the performance and economic potential of this system to conventional salt-in-tube receivers and to systems with the direct absorption receiver (DAR). SPECO, Inc., under contract to SERI, performed the receiver configuration work and their final report is included as Appendix A. The IFR is similar to the DAR in that both use films flowing over nearly vertical plates to absorb the solar energy. However, in the IFR the radiation strikes the outside of the absorber plate and the working fluid flows down the inside. The results of the system-level assessment indicate that the IFR concept has the potential to deliver levelized energy costs (LEC) on the order of 5%--7% lower than the salt-in-tube receiver. Although the potential economic benefits of the IFR are not as great as those for the DAR, which shows more than a 15% improvement in LEC over the salt-in-tube receiver system, this may be offset by the lower technical risks with the IFR. 3 refs., 2 figs., 7 tabs.

  5. Receiver functions: An exploration seismic perspective

    NASA Astrophysics Data System (ADS)

    van Manen, Dirk-Jan; Curtis, Andrew; Robertsson, Johan

    2015-04-01

    The receiver function technique is arguably the most successful technique in seismology for crustal and upper mantle characterisation. Prompted by the successful application of the receiver function method to multi-component seabed seismic data to derive shear-wave statics, we explore to what extent the receiver function method can be used for general multi-component reflection seismic data processing and vice-versa. We show that the work in the seismological community on moveout correction and stacking of receiver functions can be extended significantly, building on results from the exploration seismic community. We introduce a novel type of space-time domain receiver function, computed by 2D deconvolution, which treats the spatial aspects of mode-conversion completely analogously to the temporal aspects. Thus, the receiver function becomes a two-dimensional transfer function, which shows how far the P-waves have to be shifted in space and delayed in time to match the corresponding PS-converted waves. In addition, series expansions of the traveltime differences lead naturally to two-term moveout approximations and Dix-Krey-type velocity inversion formulae for both the conventional (i.e., time difference as a function of slowness) as well as novel (i.e., time difference as a function of offset) receiver functions. The two approaches, and the required data pre-processing, are illustrated using synthetic multi-component seismic data. We also introduce a model-independent method for reflection receiver function computation, based on stationary phase analysis, which can be used for deconvolution of anelastic and all other propagation effects. This method is inspired by, and closely related to, interferometry and relies on matching the slowness of a particular PP-reflected wave to the slowness of the corresponding PS-converted wave on the source side, and exploiting the fact that the traveltime difference is stationary for the PP- and PS-wave that is reflected and mode

  6. Performance outlook of the SCRAP receiver

    NASA Astrophysics Data System (ADS)

    Lubkoll, Matti; von Backström, Theodor W.; Harms, Thomas M.

    2016-05-01

    A combined cycle (CC) concentrating solar power (CSP) plant provides significant potential to achieve an efficiency increase and an electricity cost reduction compared to current single-cycle plants. A CC CSP system requires a receiver technology capable of effectively transferring heat from concentrated solar irradiation to a pressurized air stream of a gas turbine. The small number of pressurized air receivers demonstrated to date have practical limitations, when operating at high temperatures and pressures. As yet, a robust, scalable and efficient system has to be developed and commercialized. A novel receiver system, the Spiky Central Receiver Air Pre-heater (SCRAP) concept has been proposed to comply with these requirements. The SCRAP system is conceived as a solution for an efficient and robust pressurized air receiver that could be implemented in CC CSP concepts or standalone solar Brayton cycles without a bottoming Rankine cycle. The presented work expands on previous publications on the thermal modeling of the receiver system. Based on the analysis of a single heat transfer element (spike), predictions for its thermal performance can be made. To this end the existing thermal model was improved by heat transfer characteristics for the jet impingement region of the spike tip as well as heat transfer models simulating the interaction with ambient. While the jet impingement cooling effect was simulated employing a commercial CFD code, the ambient heat transfer model was based on simplifying assumptions in order to employ empirical and analytical equations. The thermal efficiency of a spike under design conditions (flux 1.0 MW/m2, air outlet temperature just below 800 °C) was calculated at approximately 80 %, where convective heat losses account for 16.2 % of the absorbed radiation and radiative heat losses for a lower 2.9 %. This effect is due to peak surface temperatures occurring at the root of the spikes. It can thus be concluded that the geometric

  7. Sexual function in women receiving maintenance dialysis.

    PubMed

    Seethala, Srikanth; Hess, Rachel; Bossola, Maurizio; Unruh, Mark L; Weisbord, Steven D

    2010-01-01

    While substantial attention has been paid to the issue of sexual dysfunction in men on chronic dialysis, less is known about this problem in women with end-stage renal disease. We sought to assess sexual dysfunction in women on chronic dialysis and determine whether patients discuss this problem with their providers and receive treatment. We prospectively enrolled women receiving chronic hemodialysis or peritoneal dialysis in Pittsburgh, PA. We asked patients to complete the 19-item Female Sexual Function Index (FSFI) to assess sexual function and a 5-item survey that assessed whether patients had discussed sexual dysfunction with their providers and/or received treatment for this problem in the past. We enrolled 66 patients; 59 (89%) on hemodialysis and 7 (11%) on peritoneal dialysis. All patients completed the FSFI, of whom 53 (80%) had FSFI scores <26.55, consistent with the presence of sexual dysfunction. Of 37 patients who were married or residing with a significant other, 27 (73%) had sexual dysfunction. Among 24 participants who reported having been sexually active over the previous 4 weeks, 11 (46%) had sexual dysfunction. Only 21% of patients with sexual dysfunction had discussed this problem with their gynecologist, renal or primary provider, and 3 (6%) reported having received treatment. Sexual dysfunction is common in women on dialysis, even among patients who are married or residing with a significant other and those who are sexually active. However, few women discuss this issue with their providers or receive treatment.

  8. GPS high dynamic receiver tracking demonstration results

    NASA Technical Reports Server (NTRS)

    Hurd, W. J.; Statman, J. I.; Vilnrotter, V. A.

    1985-01-01

    Demonstration results are presented for a high dynamic GPS receiver. The receiver tested is a breadboard unit capable of tracking one simulated satellite signal in pseudorange and range rate. The receiver makes approximate maximum likelihood estimates of pseudorange and range rate each 20 ms, and tracks these observables using a third order filter with a time constant of 0.14 s. Carrier phase is not tracked, which eliminates the typical failure mode of loss of carrier lock associated with PLLs at high dynamics. The receiver tracks with pseudorange lag errors of under 0.06 m when subjected to simulated 50 g turns with 40 g/s peak jerk. Pseudorange errors due to receiver noise alone are approximately 0.6 m rms at a carrier power to noise spectral density ratio of 34 dB-Hz. The tracking threshold SNR is approximately 28 dB-Hz, which provides 12 dB margin relative to the 40 dB-Hz that occurs with minimum specified satellite signal strength, 3.5 dB system noise figure, and 0 dBi antenna gain.

  9. Dish/stirling hybrid-receiver

    DOEpatents

    Mehos, Mark S.; Anselmo, Kenneth M.; Moreno, James B.; Andraka, Charles E.; Rawlinson, K. Scott; Corey, John; Bohn, Mark S.

    2002-01-01

    A hybrid high-temperature solar receiver is provided which comprises a solar heat-pipe-receiver including a front dome having a solar absorber surface for receiving concentrated solar energy, a heat pipe wick, a rear dome, a sidewall joining the front and the rear dome, and a vapor and a return liquid tube connecting to an engine, and a fossil fuel fired combustion system in radial integration with the sidewall for simultaneous operation with the solar heat pipe receiver, the combustion system comprising an air and fuel pre-mixer, an outer cooling jacket for tangentially introducing and cooling the mixture, a recuperator for preheating the mixture, a burner plenum having an inner and an outer wall, a porous cylindrical metal matrix burner firing radially inward facing a sodium vapor sink, the mixture ignited downstream of the matrix forming combustion products, an exhaust plenum, a fossil-fuel heat-input surface having an outer surface covered with a pin-fin array, the combustion products flowing through the array to give up additional heat to the receiver, and an inner surface covered with an extension of the heat-pipe wick, a pin-fin shroud sealed to the burner and exhaust plenums, an end seal, a flue-gas diversion tube and a flue-gas valve for use at off-design conditions to limit the temperature of the pre-heated air and fuel mixture, preventing pre-ignition.

  10. Direct broadcast satellite-radio, receiver development

    NASA Astrophysics Data System (ADS)

    Vaisnys, A.; Bell, D.; Gevargiz, J.; Golshan, Nasser

    The status of the ongoing Direct Broadcast Satellite-Radio (DBS-R) Receiver Development Task being performed at the Jet Propulsion Laboratory, California Institute of Technology (JPL) is reported. This work is sponsored by the Voice of America/U.S. Information Agency through an agreement with NASA. The objective of this task is to develop, build, test, and demonstrate a prototype receiver that is compatible with reception of digital audio programs broadcast via satellites. The receiver is being designed to operate under a range of reception conditions, including fixed, portable, and mobile, as well as over a sufficiently wide range of bit rates to accommodate broadcasting systems with different cost/audio quality objectives. While the requirements on the receiver are complex, the eventual goal of the design effort is to make the design compatible with low cost production as a consumer product. One solution may be a basic low cost core design suitable for a majority of reception conditions, with optional enhancements for reception in especially difficult environments. Some of the receiver design parameters were established through analysis, laboratory tests, and a prototype satellite experiment accomplished in late 1991. Many of the necessary design trades will be made during the current simulation effort, while a few of the key design options will be incorporated into the prototype for evaluation during the planned satellite field trials.

  11. Schottky Heterodyne Receivers With Full Waveguide Bandwidth

    NASA Technical Reports Server (NTRS)

    Hesler, Jeffrey; Crowe, Thomas

    2011-01-01

    Compact THz receivers with broad bandwidth and low noise have been developed for the frequency range from 100 GHz to 1 THz. These receivers meet the requirements for high-resolution spectroscopic studies of planetary atmospheres (including the Earth s) from spacecraft, as well as airborne and balloon platforms. The ongoing research is significant not only for the development of Schottky mixers, but also for the creation of a receiver system, including the LO chain. The new receivers meet the goals of high sensitivity, compact size, low total power requirement, and operation across complete waveguide bands. The exceptional performance makes these receivers ideal for the broader range of scientific and commercial applications. These include the extension of sophisticated test and measurement equipment to 1 THz and the development of low-cost imaging systems for security applications and industrial process monitoring. As a particular example, a WR-1.9SHM (400-600 GHz) has been developed (see Figure 1), with state-of-the-art noise temperature ranging from 1,000-1,800 K (DSB) over the full waveguide band. Also, a Vector Network Analyzer extender has been developed (see Figure 2) for the WR1.5 waveguide band (500 750 GHz) with 100-dB dynamic range.

  12. Direct broadcast satellite-radio, receiver development

    NASA Technical Reports Server (NTRS)

    Vaisnys, A.; Bell, D.; Gevargiz, J.; Golshan, Nasser

    1993-01-01

    The status of the ongoing Direct Broadcast Satellite-Radio (DBS-R) Receiver Development Task being performed at the Jet Propulsion Laboratory, California Institute of Technology (JPL) is reported. This work is sponsored by the Voice of America/U.S. Information Agency through an agreement with NASA. The objective of this task is to develop, build, test, and demonstrate a prototype receiver that is compatible with reception of digital audio programs broadcast via satellites. The receiver is being designed to operate under a range of reception conditions, including fixed, portable, and mobile, as well as over a sufficiently wide range of bit rates to accommodate broadcasting systems with different cost/audio quality objectives. While the requirements on the receiver are complex, the eventual goal of the design effort is to make the design compatible with low cost production as a consumer product. One solution may be a basic low cost core design suitable for a majority of reception conditions, with optional enhancements for reception in especially difficult environments. Some of the receiver design parameters were established through analysis, laboratory tests, and a prototype satellite experiment accomplished in late 1991. Many of the necessary design trades will be made during the current simulation effort, while a few of the key design options will be incorporated into the prototype for evaluation during the planned satellite field trials.

  13. Liquid cooled, linear focus solar cell receiver

    DOEpatents

    Kirpich, A.S.

    1983-12-08

    Separate structures for electrical insulation and thermal conduction are established within a liquid cooled, linear focus solar cell receiver for use with parabolic or Fresnel optical concentrators. The receiver includes a V-shaped aluminum extrusion having a pair of outer faces each formed with a channel receiving a string of solar cells in thermal contact with the extrusion. Each cell string is attached to a continuous glass cover secured within the channel with spring clips to isolate the string from the external environment. Repair or replacement of solar cells is effected simply by detaching the spring clips to remove the cover/cell assembly without interrupting circulation of coolant fluid through the receiver. The lower surface of the channel in thermal contact with the cells of the string is anodized to establish a suitable standoff voltage capability between the cells and the extrusion. Primary electrical insulation is provided by a dielectric tape disposed between the coolant tube and extrusion. Adjacent solar cells are soldered to interconnect members designed to accommodate thermal expansion and mismatches. The coolant tube is clamped into the extrusion channel with a releasably attachable clamping strip to facilitate easy removal of the receiver from the coolant circuit.

  14. Liquid cooled, linear focus solar cell receiver

    DOEpatents

    Kirpich, Aaron S.

    1985-01-01

    Separate structures for electrical insulation and thermal conduction are established within a liquid cooled, linear focus solar cell receiver for use with parabolic or Fresnel optical concentrators. The receiver includes a V-shaped aluminum extrusion having a pair of outer faces each formed with a channel receiving a string of solar cells in thermal contact with the extrusion. Each cell string is attached to a continuous glass cover secured within the channel with spring clips to isolate the string from the external environment. Repair or replacement of solar cells is effected simply by detaching the spring clips to remove the cover/cell assembly without interrupting circulation of coolant fluid through the receiver. The lower surface of the channel in thermal contact with the cells of the string is anodized to establish a suitable standoff voltage capability between the cells and the extrusion. Primary electrical insulation is provided by a dielectric tape disposed between the coolant tube and extrusion. Adjacent solar cells are soldered to interconnect members designed to accommodate thermal expansion and mismatches. The coolant tube is clamped into the extrusion channel with a releasably attachable clamping strip to facilitate easy removal of the receiver from the coolant circuit.

  15. Evolution of clinical understanding: paroxysmal nocturnal hemoglobinuria as a paradigm.

    PubMed

    Rosse, W F

    1993-01-01

    In recounting the history of the development of knowledge about PNH, the roles of the clinician, the basic scientist, and the clinician-investigator are apparent. Without the observations of the clinicians, the problem could not be posed. Without the contributions from basic science (the biochemistry of complement, the biology of glycosyl-phosphatidylinositol anchors, etc), the information necessary to the solution of the problem would not be available. Without the synthesis of the clinician-investigator, the two elements would not be fused to result in knowledge about the disease.

  16. The ARSQ: the athletes' received support questionnaire.

    PubMed

    Freeman, Paul; Coffee, Pete; Moll, Tjerk; Rees, Tim; Sammy, Nadine

    2014-04-01

    To address calls for context-specific measurement of social support, this article reports the development of the Athletes' Received Support Questionnaire (ARSQ) and demonstrates initial evidence for its validity. Across four studies there was support for a four-dimensional structure reflecting emotional, esteem, informational, and tangible received support. There was also support for unidimensional and higher-order models. Further, Study 3 provided some support for convergent validity, with significant correlations between the corresponding dimensions of the ARSQ and the Inventory of Socially Supportive Behaviors. Study 4 provided evidence for the nomological validity of the ARSQ. Emotional and esteem support significantly predicted self-confidence and positive affect, and tangible support significantly moderated the relationship between stress and negative affect. Collectively, these results provide initial evidence for the validity of the ARSQ, and offer researchers flexibility to adopt either a multidimensional or aggregated approach to measuring received support. PMID:24686955

  17. Optical Receiver Based On Luminescent Light Trapping

    NASA Technical Reports Server (NTRS)

    Perry, Joseph W.; Cole, Terry; Zewail, Ahmed H.

    1991-01-01

    Experiment demonstrates feasibility of optical-communication receiver based on luminescent light trapping. Light-gathering element plate of transparent material impregnated with laser dye. Light from distant laser transmitter falls on plate and absorbed by dye molecules, which become excited and reradiate. Reradiated light confined within plate by total internal reflection as it propagates toward edge of plate. Light arriving at edge escapes from plate and detected by small, high-speed, high-gain photomultiplier tubes or other photosensitive devices. Simple, inexpensive, and accepts light from almost any angle. Receiver of this configuration supports reception of data at rate of 13 MHz and higher.

  18. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III

    1976-01-01

    The design of a microwave landing system (MLS) aircraft receiver, capable of optimal performance in multipath environments found in air terminal areas, is reported. Special attention was given to the angle tracking problem of the receiver and includes tracking system design considerations, study and application of locally optimum estimation involving multipath adaptive reception and then envelope processing, and microcomputer system design. Results show processing is competitive in this application with i-f signal processing performance-wise and is much more simple and cheaper. A summary of the signal model is given.

  19. Avalanche Photodiode Arrays for Optical Communications Receivers

    NASA Technical Reports Server (NTRS)

    Srinivasan, M.; Vilnrotter, V.

    2001-01-01

    An avalanche photodiode (APD) array for ground-based optical communications receivers is investigated for the reception of optical signals through the turbulent atmosphere. Kolmogorov phase screen simulations are used to generate realistic spatial distributions of the received optical field. It is shown that use of an APD array for pulse-position modulation detection can improve performance by up to 4 dB over single APD detection in the presence of turbulence, but that photon-counting detector arrays yield even greater gains.

  20. Infrared receiver having a cooled radiation detector

    SciTech Connect

    Van Antwerpen, H. C.

    1985-04-09

    An infrared receiver having an infrared radiation detector cooled by means of a cold-gas engine, the thermal contact between a cooling surface of the cold-gas engine and the radiation detector being obtained by an elastic thermally conducting bridge. The cylindrical bridge is comprised of a plurality of turns of a metal strip. Due to the presence of the bridge, a good thermal conduction and further a compensation for differences in thermal expansion coefficients of the materials used are obtained. The infrared receiver is particularly suitable for night vision apparatus.

  1. Turbulent flow inside a solar concentrator receiver

    NASA Astrophysics Data System (ADS)

    Ramirez, Manuel; Ramos, Eduardo

    2014-11-01

    A solar concentrator receiver is a heat exchanger designed to absorb a beam of radiant heat coming from a field of heliostats. Inside the device, a slow forced flow generated bye an external pressure gradient is present, together with a natural convective a turbulent flow produced by the large temperature gradients due to intense heating. We present a model of this device based on the numerical solution of the mass, momentum and energy conservation equations. We consider heating conditions that lead to turbulence convective flow. For this season, a large eddy simulation model is incorporated. The results are potentially useful for the design of solar concentrator receivers.

  2. Downhole receiver function: A case study

    USGS Publications Warehouse

    Mehta, K.; Snieder, R.; Graizer, V.

    2007-01-01

    Receiver function is defined as the spectral ratio of the radial component and the vertical component of the ground motion. It is used to characterize converted waves. We extend the use of the receiver function to downhole data using waves recorded in a borehole, excited by an earthquake of magnitude 4.0 near San Francisco, California, on 26 June 1994. The focal depth of the event was 6.6 km and the epicenter was located at a distance of 12.6 km from the borehole array. Six three-component sensors were located at different depths in a borehole. To extract a coherent response of the near-surface from the incoherent earthquake waves, we deconvolve the waves recorded by the sensors at different depths with the waves recorded by the sensor on the surface. Deconvolution applied to the waves in the S-time window recorded by the radial component result in an upgoing and a downgoing wave propagating with S-wave velocity. For the waves in the P-time window recorded by the radial component, deconvolution also gives an upgoing and a down-going wave propagating with S-wave velocity. This interesting result suggests a P-to-S conversion at a depth below the deepest sensor. To diagnose this we compute the receiver function for the borehole recording of the earthquake waves. The receiver function shows an upgoing wave with an arrival close to time t = 0 for the deepest sensor. The agreement of the upgoing wave in the receiver function with the travel-time curve for the P-to-S converted wave, calculated using the P- and the S-wave velocity profile, supports the hypothesis of a pronounced P-to-S conversion. We present a synthetic example to illustrate that the first arrival of the receiver function applied to borehole data gives the upward-propagating P-to-S converted wave. To corroborate the observation of the mode conversion, we apply receiver function to a different earthquake data recorded by the same borehole array in 1998. The focal depth of the event was 6.9 km and the

  3. PiVoT GPS Receiver

    NASA Technical Reports Server (NTRS)

    Wennersten, Miriam Dvorak; Banes, Anthony Vince; Boegner, Gregory J.; Dougherty, Lamar; Edwards, Bernard L.; Roman, Joseph; Bauer, Frank H. (Technical Monitor)

    2001-01-01

    NASA Goddard Space Flight Center has built an open architecture, 24 channel space flight GPS receiver. The CompactPCI PiVoT GPS receiver card is based on the Mitel/GEC Plessey Builder-2 board. PiVoT uses two Plessey 2021 correlators to allow tracking of up to 24 separate GPS SV's on unique channels. Its four front ends can support four independent antennas, making it a useful card for hosting GPS attitude determination algorithms. It has been built using space quality, radiation tolerant parts. The PiVoT card will track a weaker signal than the original Builder 2 board. It also hosts an improved clock oscillator. The PiVoT software is based on the original Plessey Builder 2 software ported to the Linux operating system. The software is POSIX complaint and can easily be converted to other POSIX operating systems. The software is open source to anyone with a licensing agreement with Plessey. Additional tasks can be added to the software to support GPS science experiments or attitude determination algorithms. The next generation PiVoT receiver will be a single radiation hardened CompactPCI card containing the microprocessor and the GPS receiver optimized for use above the GPS constellation. PiVoT was flown successfully on a balloon in July, 2001, for its first non-simulated flight.

  4. 7 CFR 29.42 - Receiving station.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.42 Receiving station. Points at which producer tobacco is offered for marketing (other than sale at auction on a designated market), including tobacco auction warehouses,...

  5. Reasons Parents Exempt Children from Receiving Immunizations

    ERIC Educational Resources Information Center

    Luthy, Karlen E.; Beckstrand, Renea L.; Callister, Lynn C.; Cahoon, Spencer

    2012-01-01

    School nurses are on the front lines of educational efforts to promote childhood vaccinations. However, some parents still choose to exempt their children from receiving vaccinations for personal reasons. Studying the beliefs of parents who exempt vaccinations allows health care workers, including school nurses, to better understand parental…

  6. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... extends beyond the plane surfaces of the enclosure. (2) Maximum test voltage means 130 root mean square volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources... nominal 110 to 120 root mean square volts, maximum test voltage means 110 percent of the nominal root...

  7. Hybrid receiver conceptual design and test report

    NASA Technical Reports Server (NTRS)

    Klare, S. W.; Crawford, J. J.

    1978-01-01

    The Hybrid Receiver described uses an acquisition and demodulation scheme tailored to the Jovian environment. The large Doppler offsets expected during initial acquisition led to development of the Hilbert Acquisition Aid, which provides for rapid acquisition for low signal to noise densities.

  8. Developmental trends in radio receiver design

    NASA Astrophysics Data System (ADS)

    Chistyakov, N. I.

    1984-03-01

    A historical review of the development of shortwave receiver design is followed by an enumeration of the characteristics of the state of the art in shortwave reception equipment: (1) the problem of band coverage, for example in marine receivers from 10 KHz to 30 MHz, has been resolved by the use of infradyne circuits with an IF of 40 to 80 MHz and a broadband preselector; such designs also make it possible to base the local oscillator on a phase-locked loop; (20 suppression of spurious frequencies is improved by placing them outside the working band through the use of a high first IF; (3) enhanced linearity of the broadband RF amplifier and converter has extended the dynamic range of receivers, and eliminated the need for a narrow band preselector with the use of simple suboctave filters and low pass filters at the input; and (4) the use of a decade frequency synthesizer based on a variable divisor frequency divider, highly stable master crystal oscillators, electronic varactor tuning of the local oscillator and Phase-locked loops provide for precise tuning to the requisite frequency, which is also improved by digital tuning and displays. A major aspect of present design work is the application of microprocessors to automatic tuning, programmed frequency setting and the performance of a variety of diagnostic functions in the receiver.

  9. Global lithospheric imaging using teleseismic receiver functions

    NASA Astrophysics Data System (ADS)

    Rondenay, S.; Spieker, K.; Halpaap, F.; Farestveit, M.; Sawade, L.; Zijerveld, L.

    2015-12-01

    Project GLImER (Global Lithospheric Imagining using Earthquake Recordings) aims to conduct a global survey of lithospheric interfaces using converted teleseismic body waves. Data from permanent and temporary seismic networks worldwide will be processed automatically to produce global maps of key interfaces (Moho, intra-lithospheric interfaces, lithosphere-asthenosphere boundary). In this presentation, we discuss the challenges associated with automating the analysis of converted waves and the potential of the resulting data products to be used in novel imaging approaches. With regards to automation, we address in particular the search for an optimal deconvolution method in receiver function analysis. To do so, we carry out a systematic comparison of various commonly used deconvolution methods and find that all methods produce equally robust receiver functions provided that a suitable regularization parameter is found. We further note that a suitable regularization can be found objectively for most approaches, thus challenging the belief that only time-domain deconvolution is a viable option for receiver function automation. With regards to imaging applications, we investigate how the resulting global database of receiver functions will be amenable to existing processing approaches as well as new approaches adapted from seismic exploration, including industry-based interpretation tools.

  10. Kopp Receives 2012 William Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Kirschvink, Joseph L.

    2013-10-01

    Robert E. Kopp received the 2012 William Gilbert Award at the 2012 AGU Fall Meeting, held 3-7 December in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  11. Determining the response of an FM receiver

    NASA Technical Reports Server (NTRS)

    Perry, J. C.

    1979-01-01

    Frequency response to frequency-modulation (FM) receiver is measured with aid of phase-modulation (PM) transmitter by applying correction to output power level. As modulating frequency is increased, output level obtained in response to PM input is reduced by 6 db per octane.

  12. Antennas For Receiving Signals Broadcast Via Satellites

    NASA Technical Reports Server (NTRS)

    Wu, Te-Kao; Huang, John

    1996-01-01

    Four different antennas designed for use in receiving radio AM and FM signals broadcast via Earth-orbiting satellites at carrier frequency of 2.05 GHz in right-hand circular polarization. Antennas small, lightweight, inexpensive units with low-to-medium-gain, quasi-omnidirectional radiation patterns. Designed for outdoor and indoor uses.

  13. The new MTLRS-1 receiving system

    NASA Technical Reports Server (NTRS)

    Sperber, Peter; Hessels, U.; Motz, R.; Guether, H.-M.

    1993-01-01

    In this report, we are giving a detailed description of the new receiving system of the German Modular Transportable Laser Ranging System MTLRS-1, consisting of a spectral time and field of view filter and a Single Photon Avalanche Diode (SPAD) as a single photon detector. The system gives full day and night ranging capability to all satellites with cm accuracy.

  14. Vulcan: A deep-towed CSEM receiver

    NASA Astrophysics Data System (ADS)

    Constable, Steven; Kannberg, Peter K.; Weitemeyer, Karen

    2016-03-01

    We have developed a three-axis electric field receiver designed to be towed behind a marine electromagnetic transmitter for the purpose of mapping the electrical resistivity in the upper 1000 m of seafloor geology. By careful adjustment of buoyancy and the use of real-time monitoring of depth and altitude, we are able to deep-tow multiple receivers on arrays up to 1200 m long within 50 m of the seafloor, thereby obtaining good coupling to geology. The rigid body of the receiver is designed to reduce noise associated with lateral motion of flexible antennas during towing, and allows the measurement of the vertical electric field component, which modeling shows to be particularly sensitive to near-seafloor resistivity variations. The positions and orientations of the receivers are continuously measured, and realistic estimates of positioning errors can be used to build an error model for the data. During a test in the San Diego Trough, offshore California, inversions of the data were able to fit amplitude and phase of horizontal electric fields at three frequencies on three receivers to about 1% in amplitude and 1° in phase and vertical fields to about 5% in amplitude and 5° in phase. The geological target of the tests was a known cold seep and methane vent in 1000 m water depth, which inversions show to be associated with a 1 km wide resistor at a depth between 50 and 150 m below seafloor. Given the high resistivity (30 Ωm) and position within the gas hydrate stability field, we interpret this to be massive methane hydrate.

  15. The 30-GHz monolithic receive module

    NASA Technical Reports Server (NTRS)

    Bauhahn, P.; Geddes, J.; Sokolov, V.; Contolatis, T.

    1988-01-01

    The fourth year progress is described on a program to develop a 27.5 to 30 GHz GaAs monolithic receive module for spaceborne-communication antenna feed array applications, and to deliver submodules for experimental evaluation. Program goals include an overall receive module noise figure of 5 dB, a 30 dB RF to IF gain with six levels of intermediate gain control, a five bit phase shifter, and a maximum power consumption of 250 mW. Submicron gate length single and dual gate FETs are described and applied in the development of monolithic gain control amplifiers and low noise amplifiers. A two-stage monolithic gain control amplifier based on ion implanted dual gate MESFETs was designed and fabricated. The gain control amplifier has a gain of 12 dB at 29 GHz with a gain control range of over 13 dB. A two-stage monolithic low noise amplifier based on ion implanted MESFETs which provides 7 dB gain with 6.2 dB noise figure at 29 GHz was also developed. An interconnected receive module containing LNA, gain control, and phase shifter submodules was built using the LNA and gain control ICs as well as a monolithic phase shifter developed previously under this program. The design, fabrication, and evaluation of this interconnected receiver is presented. Progress in the development of an RF/IF submodule containing a unique ion implanted diode mixer diode and a broadband balanced mixer monolithic IC with on-chip IF amplifier and the initial design of circuits for the RF portion of a two submodule receiver are also discussed.

  16. Second-generation central receiver technology comparison

    NASA Astrophysics Data System (ADS)

    Klimas, P. C.; Becker, M.

    Fifteen years of solar thermal technology development have produced a considerable amount of knowledge relating to the production of electricity from central receiver power plants. This body of knowledge is under examination by researchers from the United States and the Federal Republic of Germany for the purpose of defining the next generation central receiver electricity producers. This second generation power plant is expected to represent a significant step towards commercialization of these systems. During the course of the study, specific activities needed to realize this next-step technology are being defined. The study is an international team effort. Under the International Energy Agency Small Solar Power Systems project, researchers from DLR, Interatom, Sandia National Laboratories, and Bechtel have designed a study in which technologies relating to existing systems are quantified, logical next-step systems are characterized, and future potential advances are identified. The receiver concepts under investigation are: salt-in-tube, volumetric, and direct absorption. Two plant performance levels are examined, 30 and 100 MW(sub e). Each concept is applied with common capacity factors, solar multiples, and types and sizes of heliostats at each performance level. Availability and uncertainty analyses are also performed. Annual energy production figures are calculated using the SOLERGY computer code. Capital and Operation and Maintenance cost methodologies are mutually agreed upon in order that levelized energy cost calculations will be consistent for each power plant. During the course of this effort, further potential advances in central receiver technology have continued to become apparent. These possible areas for improvement will be described. An additional comparison is being made between central receivers and trough-based systems.

  17. Social effects of migration in receiving countries.

    PubMed

    Ohndorf, W

    1989-06-01

    This paper examines the impact of post-1945 migration into Western, Middle, and Northern Europe from Southern Europe, Turkey, and Northern Africa, and migration to the traditional immigration countries by Asian and Latin American immigrants, on the social structures of receiving countries. Between 1955 and 1974, 1) traditional migration to the US and Australia became less important for European countries while traditional receiving countries accepted many immigrants from developing countries; and 2) rapid economic revival in Western and Northern Europe caused a considerable labor shortage which was filled by migrant workers especially from Southern Europe, Turkey, and Northern Africa, who stayed only until they reached their economic goals. Since 1974, job vacancies have declined and unemployment has soared. This employment crisis caused some migrants 1) to return to their countries of origin, 2) to bring the rest of their families to the receiving country, or 3) to lengthen their stay considerably. The number of refugees has also significantly increased since the mid-970s, as has the number of illegal migrants. After the mid-1970s, Europe began to experience integration problems. The different aspects of the impact of migration on social structures include 1) improvement of the housing situation for foreigners, 2) teaching migrants the language of the receiving country, 3) solving the unemployment problem of unskilled migrants, 4) improvement of educational and vocational qualifications of 2nd generation migrants, 5) development of programs to help unemployed wives of migrants to learn the language and meet indigenous women, 6) encouraging migrants to maintain their cultural identity and assisting them with reintegration if they return to their original country, 7) coping with the problems of refugees, and 8) solving the problems of illegal migration. Almost all receiving countries now severely restrict further immigration. [Those policies should result in

  18. A GPS Receiver for Lunar Missions

    NASA Technical Reports Server (NTRS)

    Bamford, William A.; Heckler, Gregory W.; Holt, Greg N.; Moreau, Michael C.

    2008-01-01

    Beginning with the launch of the Lunar Reconnaissance Orbiter (LRO) in October of 2008, NASA will once again begin its quest to land humans on the Moon. This effort will require the development of new spacecraft which will safely transport people from the Earth to the Moon and back again, as well as robotic probes tagged with science, re-supply, and communication duties. In addition to the next-generation spacecraft currently under construction, including the Orion capsule, NASA is also investigating and developing cutting edge navigation sensors which will allow for autonomous state estimation in low Earth orbit (LEO) and cislunar space. Such instruments could provide an extra layer of redundancy in avionics systems and reduce the reliance on support and on the Deep Space Network (DSN). One such sensor is the weak-signal Global Positioning System (GPS) receiver "Navigator" being developed at NASA's Goddard Space Flight Center (GSFC). At the heart of the Navigator is a Field Programmable Gate Array (FPGA) based acquisition engine. This engine allows for the rapid acquisition/reacquisition of strong GPS signals, enabling the receiver to quickly recover from outages due to blocked satellites or atmospheric entry. Additionally, the acquisition algorithm provides significantly lower sensitivities than a conventional space-based GPS receiver, permitting it to acquire satellites well above the GPS constellation. This paper assesses the performance of the Navigator receiver based upon three of the major flight regimes of a manned lunar mission: Earth ascent, cislunar navigation, and entry. Representative trajectories for each of these segments were provided by NASA. The Navigator receiver was connected to a Spirent GPS signal generator, to allow for the collection of real-time, hardware-in-the-loop results for each phase of the flight. For each of the flight segments, the Navigator was tested on its ability to acquire and track GPS satellites under the dynamical

  19. Integrated Microphotonic Receiver for Ka-Band

    NASA Technical Reports Server (NTRS)

    Levi, A. F. J.

    2005-01-01

    This report consists of four main sections. Part I: LiNbO3 microdisk resonant optical modulator. Brief review of microdisk optical resonator and RF ring resonator. Microwave and photonic design challenges for achieving simultaneous RF-optical resonance are addressed followed by our solutions. Part II: Experimental demonstration of LiNbO3 microdisk modulator performance in wired and wireless RF-optical links. Part III: Microphotonic RF receiver architecture that exploits the nonlinear modulation in the LiNbO3 microdisk modulator to achieve direct photonic down-conversion from RF carrier without using any high-speed electronic elements. Part IV: Ultimate sensitivity of the microdisk photonic receiver and the future road map toward a practical device.

  20. Cryogenic Amplifier Based Receivers at Submillimeter Wavelengths

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam; Reck, Theodore and; Schlecht, Erich; Lin, Robert; Deal, William

    2012-01-01

    The operating frequency of InP high electron mobility transistor (HEMT) based amplifiers has moved well in the submillimeter-wave frequencies over the last couple of years. Working amplifiers with usable gain in waveguide packages has been reported beyond 700 GHz. When cooled cryogenically, they have shown substantial improvement in their noise temperature. This has opened up the real possibility of cryogenic amplifier based heterodyne receivers at submillimeter wavelengths for ground-based, air-borne, and space-based instruments for astrophysics, planetary, and Earth science applications. This paper provides an overview of the science applications at submillimeter wavelengths that will benefit from this technology. It also describes the current state of the InP HEMT based cryogenic amplifier receivers at submillimeter wavelengths.

  1. Hyperammonemia in neonates receiving intravenous nutrition.

    PubMed

    Thomas, D W; Sinatra, F R; Hack, S L; Smith, T M; Platzker, A C; Merritt, R J

    1982-01-01

    Inadequate arginine intake has been suggested as an etiology for hyperammonemia in neonates on parenteral nutrition. We randomized 26 nonasphyxiated neonates to receive amino acid solutions containing either 3.6 or 10.4% of total nitrogen as arginine when intravenous nutrition (IVN) therapy was initiated. Neonates in both amino acid solution study groups were observed to have significantly elevated blood ammonia (BA) concentrations during IVN (p less than 0.01) as compared to pre-IVN levels. Blood ammonia concentrations tended to be higher in infants receiving the 3.6% arginine amino acid solution. Septic infants were at particular risk for hyperammonemia as compared to nonseptic patients (p less than 0.025). Other clinical parameters including birth weight, gestational age, oxygen requirements, enteral nutritional intake, congenital anomalies, and heart disease did not appear to be related to BA concentration.

  2. Fused silica windows for solar receiver applications

    NASA Astrophysics Data System (ADS)

    Hertel, Johannes; Uhlig, Ralf; Söhn, Matthias; Schenk, Christian; Helsch, Gundula; Bornhöft, Hansjörg

    2016-05-01

    A comprehensive study of optical and mechanical properties of quartz glass (fused silica) with regard to application in high temperature solar receivers is presented. The dependence of rupture strength on different surface conditions as well as high temperature is analyzed, focussing particularly on damage by devitrification and sandblasting. The influence of typical types of contamination in combination with thermal cycling on the optical properties of fused silica is determined. Cleaning methods are compared regarding effectiveness on contamination-induced degradation for samples with and without antireflective coating. The FEM-aided design of different types of receiver windows and their support structure is presented. A large-scale production process has been developed for producing fused silica dome shaped windows (pressurized window) up to a diameter of 816 mm. Prototypes were successfully pressure-tested in a test bench and certified according to the European Pressure Vessel Directive.

  3. Sense and sensitivity: How ALMA receivers work

    NASA Astrophysics Data System (ADS)

    Wilson, T. L.; Mauersberger, R.; Hales, A.

    2010-09-01

    In previous articles, we described how electromagnetic waves emitted from objects in the sky are collected by the ALMA antennas (Anatomy of ALMA), and how they are combined in order to produce images. Before these images can be processed, they are picked up by the antennas and concentrated by the large main mirror and a smaller secondary mirror in the so called focal point of each antenna. In order to process the data they must be first converted to electromagnetic waves of a lower frequency and amplified. This is the role of the ALMA receivers. In principle they work like a normal FM receiver, but at much higher frequencies. Here we describe how they work and what makes them special.

  4. Screen-printed flexible MRI receive coils

    NASA Astrophysics Data System (ADS)

    Corea, Joseph R.; Flynn, Anita M.; Lechêne, Balthazar; Scott, Greig; Reed, Galen D.; Shin, Peter J.; Lustig, Michael; Arias, Ana C.

    2016-03-01

    Magnetic resonance imaging is an inherently signal-to-noise-starved technique that limits the spatial resolution, diagnostic image quality and results in typically long acquisition times that are prone to motion artefacts. This limitation is exacerbated when receive coils have poor fit due to lack of flexibility or need for padding for patient comfort. Here, we report a new approach that uses printing for fabricating receive coils. Our approach enables highly flexible, extremely lightweight conforming devices. We show that these devices exhibit similar to higher signal-to-noise ratio than conventional ones, in clinical scenarios when coils could be displaced more than 18 mm away from the body. In addition, we provide detailed material properties and components performance analysis. Prototype arrays are incorporated within infant blankets for in vivo studies. This work presents the first fully functional, printed coils for 1.5- and 3-T clinical scanners.

  5. Screen-printed flexible MRI receive coils.

    PubMed

    Corea, Joseph R; Flynn, Anita M; Lechêne, Balthazar; Scott, Greig; Reed, Galen D; Shin, Peter J; Lustig, Michael; Arias, Ana C

    2016-01-01

    Magnetic resonance imaging is an inherently signal-to-noise-starved technique that limits the spatial resolution, diagnostic image quality and results in typically long acquisition times that are prone to motion artefacts. This limitation is exacerbated when receive coils have poor fit due to lack of flexibility or need for padding for patient comfort. Here, we report a new approach that uses printing for fabricating receive coils. Our approach enables highly flexible, extremely lightweight conforming devices. We show that these devices exhibit similar to higher signal-to-noise ratio than conventional ones, in clinical scenarios when coils could be displaced more than 18 mm away from the body. In addition, we provide detailed material properties and components performance analysis. Prototype arrays are incorporated within infant blankets for in vivo studies. This work presents the first fully functional, printed coils for 1.5- and 3-T clinical scanners. PMID:26961073

  6. Graphene radio frequency receiver integrated circuit.

    PubMed

    Han, Shu-Jen; Garcia, Alberto Valdes; Oida, Satoshi; Jenkins, Keith A; Haensch, Wilfried

    2014-01-01

    Graphene has attracted much interest as a future channel material in radio frequency electronics because of its superior electrical properties. Fabrication of a graphene integrated circuit without significantly degrading transistor performance has proven to be challenging, posing one of the major bottlenecks to compete with existing technologies. Here we present a fabrication method fully preserving graphene transistor quality, demonstrated with the implementation of a high-performance three-stage graphene integrated circuit. The circuit operates as a radio frequency receiver performing signal amplification, filtering and downconversion mixing. All circuit components are integrated into 0.6 mm(2) area and fabricated on 200 mm silicon wafers, showing the unprecedented graphene circuit complexity and silicon complementary metal-oxide-semiconductor process compatibility. The demonstrated circuit performance allow us to use graphene integrated circuit to perform practical wireless communication functions, receiving and restoring digital text transmitted on a 4.3-GHz carrier signal.

  7. North Dakota geology school receives major gift

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-10-01

    Petroleum geology and related areas of study at the University of North Dakota (UND) received a huge financial boost with the announcement on 24 September of $14 million in private and public partnership funding. The university announced the naming of the Harold Hamm School of Geology and Geological Engineering, formerly a department within the College of Engineering and Mines, in recognition of $10 million provided as a gift by oilman Harold Hamm and Continental Resources, Inc. Hamm is the chair and chief executive officer of Continental, the largest leaseholder in the Bakken Play oil formation in North Dakota and Montana, and he is also an energy policy advisor to Republican presidential candidate Mitt Romney. UND also received $4 million from the Oil and Gas Research Program of the North Dakota Industrial Commission to support geology and geological engineering education and research.

  8. ICESat-2 / ATLAS Flight Science Receiver Algorithms

    NASA Astrophysics Data System (ADS)

    Mcgarry, J.; Carabajal, C. C.; Degnan, J. J.; Mallama, A.; Palm, S. P.; Ricklefs, R.; Saba, J. L.

    2013-12-01

    NASA's Advanced Topographic Laser Altimeter System (ATLAS) will be the single instrument on the ICESat-2 spacecraft which is expected to launch in 2016 with a 3 year mission lifetime. The ICESat-2 orbital altitude will be 500 km with a 92 degree inclination and 91-day repeat tracks. ATLAS is a single photon detection system transmitting at 532nm with a laser repetition rate of 10 kHz and a 6 spot pattern on the Earth's surface. Without some method of eliminating solar background noise in near real-time, the volume of ATLAS telemetry would far exceed the normal X-band downlink capability. To reduce the data volume to an acceptable level a set of onboard Receiver Algorithms has been developed. These Algorithms limit the daily data volume by distinguishing surface echoes from the background noise and allow the instrument to telemeter only a small vertical region about the signal. This is accomplished through the use of an onboard Digital Elevation Model (DEM), signal processing techniques, and an onboard relief map. Similar to what was flown on the ATLAS predecessor GLAS (Geoscience Laser Altimeter System) the DEM provides minimum and maximum heights for each 1 degree x 1 degree tile on the Earth. This information allows the onboard algorithm to limit its signal search to the region between minimum and maximum heights (plus some margin for errors). The understanding that the surface echoes will tend to clump while noise will be randomly distributed led us to histogram the received event times. The selection of the signal locations is based on those histogram bins with statistically significant counts. Once the signal location has been established the onboard Digital Relief Map (DRM) is used to determine the vertical width of the telemetry band about the signal. The ATLAS Receiver Algorithms are nearing completion of the development phase and are currently being tested using a Monte Carlo Software Simulator that models the instrument, the orbit and the environment

  9. External ground monitoring v. receiver monitoring

    NASA Astrophysics Data System (ADS)

    Johannessen, R.

    1991-01-01

    The high levels of integrity required by civil aviation in the use of satellite navigation entails that satellite warning messages be augmented by some secondary form of monitoring. The alternatives presently considered are (1) ground monitoring, in which a monitor at some fixed and surveyed ground location broadcasts a warning to the navigating aircraft when there is a malfunction; and (2) 'receiver autonomous integrity monitoring' (RAIM), in which the navigating receiver conducts its own internal monitoring. While the former can be achieved with fewer navigation satellites, RAIM has the singular advantage of requiring no additional investment for a ground-monitoring system. The present evaluation of the alternatives discusses the factors of satellite visibility, the definition of 'good' geometry, and the duration of integrity outages and their significance.

  10. VLBI2010 Receiver Back End Comparison

    NASA Technical Reports Server (NTRS)

    Petrachenko, Bill

    2013-01-01

    VLBI2010 requires a receiver back-end to convert analog RF signals from the receiver front end into channelized digital data streams to be recorded or transmitted electronically. The back end functions are typically performed in two steps: conversion of analog RF inputs into IF bands (see Table 2), and conversion of IF bands into channelized digital data streams (see Tables 1a, 1b and 1c). The latter IF systems are now completely digital and generically referred to as digital back ends (DBEs). In Table 2 two RF conversion systems are compared, and in Tables 1a, 1b, and 1c nine DBE systems are compared. Since DBE designs are advancing rapidly, the data in these tables are only guaranteed to be current near the update date of this document.

  11. Solar receiver performance of point focusing collector system

    NASA Technical Reports Server (NTRS)

    Wu, Y. C.; Wen, L. C.

    1978-01-01

    The solar receiver performance of cavity receivers and external receivers used in dispersed solar power systems was evaluated for the temperature range 300-1300 C. Several parameters of receiver and concentrator are examined. It was found that cavity receivers are generally more efficient than external receivers, especially at high temperatures which require a large heat transfer area. The effects of variation in the ratio of receiver area to aperture area are considered.

  12. Digital Signal Processor For GPS Receivers

    NASA Technical Reports Server (NTRS)

    Thomas, J. B.; Meehan, T. K.; Srinivasan, J. M.

    1989-01-01

    Three innovative components combined to produce all-digital signal processor with superior characteristics: outstanding accuracy, high-dynamics tracking, versatile integration times, lower loss-of-lock signal strengths, and infrequent cycle slips. Three components are digital chip advancer, digital carrier downconverter and code correlator, and digital tracking processor. All-digital signal processor intended for use in receivers of Global Positioning System (GPS) for geodesy, geodynamics, high-dynamics tracking, and ionospheric calibration.

  13. Counterrotator And Correlator For GPS Receivers

    NASA Technical Reports Server (NTRS)

    Thomas, J. Brooks; Srinivasan, Jeffrey M.; Meehan, Thomas K.

    1989-01-01

    Accurate, all-digital, high-speed processor comprising correlator and down-converter developed for receivers in Global Positioning System (GPS). Processor reduces roundoff and commensurability errors to extremely small values. Use of digital chip and phase advancers provides outstanding control and accuracy in phase and feedback. Great flexibility imparted by provision for arbitrary starting time and integration length. Minimum-bit design requires minimum number of logical elements, thereby reducing size, power, and cost.

  14. Integrated solar upper stage alternate receiver

    SciTech Connect

    Streckert, H.H.; Begg, L.L.; Heffernan, T.F.; Horner, M.H.

    1997-12-31

    The Integrated Solar Upper Stage (ISUS) receiver is a compact orbital transfer vehicle designed to generate thrust to boost transfer payloads from low earth orbit to Molniya or geosynchronous orbits. It can provide thrust by collecting and concentrating solar flux and heating hydrogen to {approximately} 2,500 K. Simultaneously, the ISUS receiver radiates heat into an array of thermionic converters to produce electrical power. The central component consists of a graphite body with rhenium lined internal passages. The alternate receiver relies on wrought rhenium that is rolled, machined and electron-beam welded to form a complex rhenium liner system within the graphite body. All machining operations were performed by molybdenum wire electron discharge machining. The tube forming procedure was performed to minimize the amount of cold work before annealing. Electron-beam welding was performed at a current density range of {approximately} 2 to 10 A/cm{sup 2} depending on material thickness, which melts the rhenium locally and results in a fine grained weld zone. A simplified Demonstration Test Assembly was fabricated and tested. The unit consisted of an inlet structure welded to a manifold with a simplified exhaust nozzle system and contained in a machined graphite body. The external graphite surfaces were coated with plasma sprayed rhenium for protection from graphite erosion. Testing included a hot hydrogen flow test to {approximately} 2,500 K. The main ISUS Alternate Receiver was designed and built according to the same procedures as the demonstration unit. However, the inlet and outlet plenums are more complex and are connected by 195 channels to efficiently transfer heat to the flowing hydrogen. An outlet tube containing a sonic orifice mates to the exhaust plenum.

  15. Armstrong Receives Space Medal of Honor

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Astronaut Neil A. Armstrong receives the first Congressional Space Medal of Honor from President Jimmy Carter, assisted by Captain Robert Peterson. Armstrong, one of six astronauts to be presented the medal during ceremonies held in the Vehicle Assembly Building (VAB), was awarded for his performance during the Gemini 8 mission and the Apollo 11 mission when he became the first human to set foot upon the Moon.

  16. Optical antenna gain. II - Receiving antennas

    NASA Technical Reports Server (NTRS)

    Degnan, J. J.; Klein, B. J.

    1974-01-01

    Expressions are developed for the gain of a centrally obscured, circular optical antenna used as the collecting and focusing optics in a laser receiver, involving losses due to (1) incoming light blockage by central obscuration, (2) energy spillover at the detector, and (3) the effect of local oscillator distribution in the case of heterodyne or homodyne detection. Numerical results are presented for direct detection and for three types of local oscillator distribution (uniform, Gaussian, and matched).

  17. Solar central receiver integration with Hoover Dam

    SciTech Connect

    Remmers, H.E.; Zelenka, R.L.; Kitchen, J.H.

    1980-01-01

    The technical and economic feasibility of integrating a 100 MWe solar central receiver powerplant located in Yuma, Arizona with the Hoover Dam hydroelectric power system is discussed. Technical feasibility was determined by evaluating the effects of integration on the hydrologic and power operations of the existing hydro system. Economic feasibility was determined by comparing the costs of the integrated system with that of the most likely alternative source of power generation--an oil-fired,combined-cycle plant.

  18. Hansen receives 2001 Roger Revelle Medal

    NASA Astrophysics Data System (ADS)

    Prather, Michael J.; Hansen, James E.

    James E. Hansen received the Roger Revelle Medal at the 2001 Fall Meeting Honors Ceremony on 12 December in San Francisco, California. The medal is given for outstanding contributions toward an understanding of the Earth's atmospheric processes, including its dynamics, chemistry, and radiation; the roles of atmosphere, atmosphere-ocean coupling, or atmosphere-land coupling in determining the climate, biogeochemical cycles, or other key elements of the integrated climate system.

  19. Air Brayton Solar Receiver, phase 1

    NASA Technical Reports Server (NTRS)

    Zimmerman, D. K.

    1979-01-01

    A six month analysis and conceptual design study of an open cycle Air Brayton Solar Receiver (ABSR) for use on a tracking, parabolic solar concentrator are discussed. The ABSR, which includes a buffer storage system, is designed to provide inlet air to a power conversion unit. Parametric analyses, conceptual design, interface requirements, and production cost estimates are described. The design features were optimized to yield a zero maintenance, low cost, high efficiency concept that will provide a 30 year operational life.

  20. Robust quantum receivers for coherent state discrimination

    NASA Astrophysics Data System (ADS)

    Becerra, Francisco Elohim

    2014-05-01

    Quantum state discrimination is a central task for quantum information and is a fundamental problem in quantum mechanics. Nonorthogonal states, such as coherent states which have intrinsic quantum noise, cannot be discriminated with total certainty because of their intrinsic overlap. This nonorthogonality is at the heart of quantum key distribution for ensuring absolute secure communications between a transmitter and a receiver, and can enable many quantum information protocols based on coherent states. At the same time, while coherent states are used for communications because of their robustness to loss and simplicity of generation and detection, their nonorthogonality inherently produces errors in the process of decoding the information. The minimum error probability in the discrimination of nonorthogonal coherent states measured by an ideal lossless and noiseless conventional receiver is given by the standard quantum limit (SQL). This limit sets strict bounds on the ultimate performance of coherent communications and many coherent-state-based quantum information protocols. However, measurement strategies based on the quantum properties of these states can allow for better measurements that surpass the SQL and approach the ultimate measurement limits allowed by quantum mechanics. These measurement strategies can allow for optimally extracting information encoded in these states for coherent and quantum communications. We present the demonstration of a receiver based on adaptive measurements and single-photon counting that unconditionally discriminates multiple nonorthogonal coherent states below the SQL. We also discuss the potential of photon-number-resolving detection to provide robustness and high sensitivity under realistic conditions for an adaptive coherent receiver with detectors with finite photon-number resolution.

  1. Anticoagulation: monitoring of patients receiving anticoagulation.

    PubMed

    Hawes, Emily M; Viera, Anthony J

    2014-07-01

    For patients with acute venous thromboembolism treated with warfarin, parenteral anticoagulation should be continued for a minimum of 5 days and until the international normalized ratio (INR) is 2 or greater for at least 24 hours. Early initiation of warfarin therapy is recommended. The goal therapeutic INR range for patients treated with warfarin is most commonly 2 to 3. During maintenance warfarin therapy, validated decision-support tools should be used to guide dosing. For patients with stable INRs, frequency of INR testing can be extended from every 4 weeks to up to 12 weeks. Self-testing and self-management can be safe options for patients receiving warfarin who are motivated and show competence. Patients starting anticoagulation therapy should receive education on treatment goals, adverse effects, and monitoring strategy. Physicians deciding whether to prescribe one of the new oral anticoagulants instead of warfarin should assess for possible drug interactions and for renal and hepatic impairment and should consider the financial cost to the patient. No routine coagulation assay monitoring is required for patients receiving apixaban, dabigatran, or rivaroxaban. Physicians who oversee oral anticoagulation therapy should do so in a systematic and coordinated fashion.

  2. Transient simulation of molten salt central receiver

    NASA Astrophysics Data System (ADS)

    Doupis, Dimitri; Wang, Chuan; Carcorze-Soto, Jorge; Chen, Yen-Ming; Maggi, Andrea; Losito, Matteo; Clark, Michael

    2016-05-01

    Alstom is developing concentrated solar power (CSP) utilizing 60/40wt% NaNO3-KNO3 molten salt as the working fluid in a tower receiver for the global renewable energy market. In the CSP power generation cycle, receivers undergo a daily cyclic operation due to the transient nature of solar energy. Development of robust and efficient start-up and shut-down procedures is critical to avoiding component failures due to mechanical fatigue resulting from thermal transients, thus maintaining the performance and availability of the CSP plant. The Molten Salt Central Receiver (MSCR) is subject to thermal transients during normal daily operation, a cycle that includes warmup, filling, operation, draining, and shutdown. This paper describes a study to leverage dynamic simulation and finite element analysis (FEA) in development of start-up, shutdown, and transient operation concepts for the MSCR. The results of the FEA also verify the robustness of the MSCR design to the thermal transients anticipated during the operation of the plant.

  3. On the nonuniqueness of receiver function inversions

    SciTech Connect

    Ammon, C.J. ); Randall, G.E. ); Zandt, G. )

    1990-09-10

    To study the resolving power of teleseismic P waveforms for receiver structure, the authors model synthetic waveforms using a time domain waveform inversion scheme beginning with a range of initial models to estimate the range of acceptable velocity structures. To speed up the waveform inversions, they implement Randall's (1989) efficient algorithms for calculating differential seismograms and include a smoothness constraint on all the resulting velocity models utilizing the jumping inversion technique of Shaw and Orcutt (1985). They present the results of more than 235 waveform inversions for one-dimensional velocity structures that indicate that the primary sensitivity of a receiver function is to high wavenumber velocity changes, and a depth-velocity product, not simply velocity. The range of slownesses in a typical receiver function study does not appear to be broad enough to remove the depth-velocity ambiguity; the inclusion of a priori information is necessary. They also present inversion results for station RSCP, located in the Cumberland Plateau, Tennessee. The results are similar to those from a previous study by Owens et al. (1984) and demonstrate the uncertainties in the resulting velocity estimate more clearly.

  4. Radio Astronomy Software Defined Receiver Project

    SciTech Connect

    Vacaliuc, Bogdan; Leech, Marcus; Oxley, Paul; Flagg, Richard; Fields, David

    2011-01-01

    The paper describes a Radio Astronomy Software Defined Receiver (RASDR) that is currently under development. RASDR is targeted for use by amateurs and small institutions where cost is a primary consideration. The receiver will operate from HF thru 2.8 GHz. Front-end components such as preamps, block down-converters and pre-select bandpass filters are outside the scope of this development and will be provided by the user. The receiver includes RF amplifiers and attenuators, synthesized LOs, quadrature down converters, dual 8 bit ADCs and a Signal Processor that provides firmware processing of the digital bit stream. RASDR will interface to a user s PC via a USB or higher speed Ethernet LAN connection. The PC will run software that provides processing of the bit stream, a graphical user interface, as well as data analysis and storage. Software should support MAC OS, Windows and Linux platforms and will focus on such radio astronomy applications as total power measurements, pulsar detection, and spectral line studies.

  5. Terahertz Superconducting Hot Electron Bolometer Heterodyne Receivers

    NASA Astrophysics Data System (ADS)

    Gao, J. R.; Hajenius, M..; Yang, Z. Q.; Baselmans, J. J. A.; Khosropanah, P..; Barends, R..; Klapwijk, T. M.

    2007-06-01

    We highlight the progress on NbN hot electron bolometer (HEB) mixers achieved through fruitful collaboration between SRON Netherlands Institute for Space Research and Delft University of Technology, the Netherlands. This includes the best receiver noise temperatures of 700 K at 1.63 THz using a twin-slot antenna mixer and 1050 K at 2.84 THz using a spiral antenna coupled HEB mixer. The mixers are based on thin NbN films on Si and fabricated with a new contact-process and-structure. By reducing their areas HEB mixers have shown an LO power requirement as low as 30 nW. Those small HEB mixers have demonstrated equivalent sensitivity as those with large areas provided the direct detection effect due to broadband radiation is removed. To manifest that a HEB based heterodyne receiver can in practice be used at arbitrary frequencies above 2 THz, we demonstrate a 2.8 THz receiver using a THz quantum cascade laser (QCL) as local oscillator.

  6. Towards Self-Clocked Gated OCDMA Receiver

    NASA Astrophysics Data System (ADS)

    Idris, S.; Osadola, T.; Glesk, I.

    2013-02-01

    A novel incoherent OCDMA receiver with incorporated all-optical clock recovery for self-synchronization of a time gate for the multi access interferences (MAI) suppression and minimizing the effect of data time jitter in incoherent OCDMA system was successfully developed and demonstrated. The solution was implemented and tested in a multiuser environment in an out of the laboratory OCDMA testbed with two-dimensional wavelength-hopping time-spreading coding scheme and OC-48 (2.5 Gbp/s) data rate. The self-clocked all-optical time gate uses SOA-based fibre ring laser optical clock, recovered all-optically from the received OCDMA traffic to control its switching window for cleaning the autocorrelation peak from the surrounding MAI. A wider eye opening was achieved when the all-optically recovered clock from received data was used for synchronization if compared to a static approach with the RF clock being generated by a RF synthesizer. Clean eye diagram was also achieved when recovered clock is used to drive time gating.

  7. Submillimeter heterodyne receiver for the CSO telescope

    NASA Technical Reports Server (NTRS)

    Gulkis, S.

    1988-01-01

    This task is to build a cryogenically cooled 620 to 700 GHz astronomical receiver that will be used as a facility instrument at the CalTech Submillimeter Observatory (CSO) on Mauna Kea, Hawaii. The receiver will have applications as a very high resolution spectrometer to investigate spectral lines in planetary and satellite atmospheres, and comets. The receiver will also be used to make continuum measurements of planets, satellites, and asteroids. During FY88, a scale model (200 GHz) SIS mixer radiometer was built and intrgrated into a cryostat designed for use on the CSO telescope. This system will serve as a model to guide the work on the higher frequency mixer. A solid state local oscillator source that covers two bands in the 600 to 700 GHz has been developed under contract JPL and will be delivered before the end of the year. Work has continued on the SIS materials needed for the 620 to 700 GHz mixer. Test hardware has been developed which allow the 1 to 5 curves for SIS material to be easily measured.

  8. TDRSS S-shuttle unique receiver equipment

    NASA Technical Reports Server (NTRS)

    Weinberg, A.; Schwartz, J. J.; Spearing, R.

    1985-01-01

    Beginning with STS-9, the Tracking and Date Relay Satellite system (TDRSS) will start providing S- and Ku-band communications and tracking support to the Space Shuttle and its payloads. The most significant element of this support takes place at the TDRSS White Sands Ground Terminal, which processes the Shuttle return link S- and Ku-band signals. While Ku-band hardware available to other TDRSS users is also applied to Ku-Shuttle, stringent S-Shuttle link margins have precluded the application of the standard TDRSS S-band processing equipment to S-Shuttle. It was therfore found necessary to develop a unique S-Shuttle Receiver that embodies state-of-the-art digital technology and processing techniques. This receiver, developed by Motorola, Inc., enhances link margins by 1.5 dB relative to the standard S-band equipment and its bit error rate performance is within a few tenths of a dB of theory. An overview description of the Space Shuttle Receiver Equipment (SSRE) is presented which includes the presentation of block diagrams and salient design features. Selected, measured performance results are also presented.

  9. Sensitive Broadband Receivers for Microwave Limb Sounding

    NASA Astrophysics Data System (ADS)

    Ward, J. S.; Lee, K. A.; Kawamura, J.; Chattopadhyay, G.; Stek, P. C.

    2007-12-01

    Microwave limb sounding is a proven remote-sensing technique that resolves the spectra of microwave thermal emission along a limb view of the earth's atmosphere with a cold space background. The temperature and composition of the atmosphere as a function of altitude is retrieved by analyzing the spectra returned from a vertical scan of the limb. The Microwave Limb Sounder (MLS) instrument on the NASA Upper Atmosphere Research Satellite (UARS) was the first experiment to study the microwave limb from space, and was followed by the current EOS MLS instrument on the Aura spacecraft. We are developing a new class of highly-sensitive broadband receivers for a next-generation microwave limb sounder that scans the limb in elevation and azimuth to generate a 3-D map of atmospheric composition. Sensitive receivers are needed to reduce integration times to allow the addition of rapid horizontal scanning while maintaining high measurement precision. The Scanning Microwave Limb Sounder (SMLS) will sample a 6000 km cross track swath with 50 km resolution while doubling the vertical resolution of its predecessor, Aura MLS. The wide swath allows for six or more daily samples for most of the mid latitudes. These frequent measurements, combined with the good horizontal and high vertical resolution of SMLS are key to enabling the study of fast processes in the upper troposphere affecting chemistry, climate, and air quality. Two receivers are being developed for SMLS: a 230 GHz channel will be used to study the upper troposphere and a 640 GHz channel will focus on measurements of the stratosphere. Both receivers feature broad tunable bandwidth (100 GHz each) to enable measurements of many important species including water, ozone, CO, HCN, NO, SO2, and acetone. Each receiver will downconvert the signal using a superconductor-insulator- superconductor (SIS) heterodyne mixer to achieve sensitivities of 100 K and 200 K for the 230 GHz and 640 GHz channels, respectively. The high spectral

  10. Cryogenic 160-GHz MMIC Heterodyne Receiver Module

    NASA Technical Reports Server (NTRS)

    Samoska, Lorene A.; Soria, Mary M.; Owen, Heather R.; Dawson, Douglas E.; Kangaslahti, Pekka P.; Gaier, Todd C.; Voll, Patricia; Lau, Judy; Sieth, Matt; Church, Sarah

    2011-01-01

    A cryogenic 160-GHz MMIC heterodyne receiver module has demonstrated a system noise temperature of 100 K or less at 166 GHz. This module builds upon work previously described in Development of a 150-GHz MMIC Module Prototype for Large-Scale CMB Radiation (NPO-47664), NASA Tech Briefs, Vol. 35, No. 8 (August 2011), p. 27. In the original module, the local oscillator signal was saturating the MMIC low-noise amplifiers (LNAs) with power. In order to suppress the local oscillator signal from reaching the MMIC LNAs, the W-band (75 110 GHz) signal had to be filtered out before reaching 140 170 GHz. A bandpass filter was developed to cover 120 170 GHz, using microstrip parallel-coupled lines to achieve the desired filter bandwidth, and ensure that the unwanted W-band local oscillator signal would be sufficiently suppressed. With the new bandpass filter, the entire receiver can work over the 140 180-GHz band, with a minimum system noise temperature of 460 K at 166 GHz. The module was tested cryogenically at 20 K ambient temperature, and it was found that the receiver had a noise temperature of 100 K over an 8-GHz bandwidth. The receiver module now includes a microstrip bandpass filter, which was designed to have a 3-dB bandwidth of approximately 120-170 GHz. The filter was fabricated on a 3-mil-thick alumina substrate. The filter design was based on a W-band filter design made at JPL and used in the QUIET (Q/U Imaging ExperimenT) radiometer modules. The W-band filter was scaled for a new center frequency of 150 GHz, and the microstrip segments were changed accordingly. Also, to decrease the bandwidth of the resulting scaled design, the center gaps between the microstrip lines were increased (by four micrometers in length) compared to the gaps near the edges. The use of the 150-GHz bandpass filter has enabled the receiver module to function well at room temperature. The system noise temperature was measured to be less than 600 K (at room temperature) from 154 to 168 GHz

  11. 24 CFR 982.355 - Portability: Administration by receiving PHA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... receiving PHA, the receiving PHA must promptly inform the initial PHA whether the receiving PHA will bill... §§ 982.552 and 982.553. (10) When the family has a right to lease a unit in the receiving PHA... portable family, the receiving PHA may bill the initial PHA for housing assistance payments...

  12. Receivers Gather Data for Climate, Weather Prediction

    NASA Technical Reports Server (NTRS)

    2012-01-01

    Signals from global positioning system (GPS) satellites are now being used for more than just location and navigation information. By looking at the radio waves from GPS satellites, a technology developed at NASA s Jet Propulsion Laboratory (JPL) not only precisely calculates its position, but can also use a technique known as radio occultation to help scientists study the Earth s atmosphere and gravity field to improve weather forecasts, monitor climate change, and enhance space weather research. The University Corporation for Atmospheric Research (UCAR), a nonprofit group of universities in Boulder, Colorado, compares radio occultation to the appearance of a pencil when viewed though a glass of water. The water molecules change the path of visible light waves so that the pencil appears bent, just like molecules in the air bend GPS radio signals as they pass through (or are occulted by) the atmosphere. Through measurements of the amount of bending in the signals, scientists can construct detailed images of the ionosphere (the energetic upper part of the atmosphere) and also gather information about atmospheric density, pressure, temperature, and moisture. Once collected, this data can be input into weather forecasting and climate models for weather prediction and climate studies. Traditionally, such information is obtained through the use of weather balloons. In 1998, JPL started developing a new class of GPS space science receivers, called Black Jack, that could take precise measurements of how GPS signals are distorted or delayed along their way to the receiver. By 2006, the first demonstration of a GPS radio occultation constellation was launched through a collaboration among Taiwan s National Science Council and National Space Organization, the U.S. National Science Foundation, NASA, the National Oceanic and Atmospheric Administration (NOAA), and other Federal entities. Called the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC

  13. Carboplatin pharmacokinetics in a patient receiving hemodialysis.

    PubMed

    Fong, Mei Ka; Fetterly, Gerald J; McDougald, Lori J; Iyer, Renuka V

    2014-02-01

    With refinements and advances in hemodialysis techniques, survival for patients with end-stage renal disease has improved significantly. To our knowledge, however, no prospective trials have been performed in patients receiving hemodialysis who are also diagnosed with cancer and are candidates for chemotherapy. We describe a 73-year-old man who was diagnosed with high-grade neuroendocrine carcinoma, metastatic to the bone and lymph nodes, and was undergoing hemodialysis. Although cisplatin is more commonly used in the treatment of metastatic neuroendocrine cancers, it may not be the best option in patients who suffer from renal insufficiency. Carboplatin is a second-generation, nonnephrotoxic platinum analog that can be hemodialyzed, although no formal guidelines are available regarding the dosing for patients receiving hemodialysis. This case describes a patient who was treated with five cycles of combination carboplatin 115 mg/m(2) on day 1 and etoposide 50 mg/m(2) on day 1 and day 3 of a 28-day cycle. Dialysis was performed for 3.5 hours starting 90 minutes after completion of carboplatin on day 1. Pharmacokinetic assessments were performed at 1, 2, 4, and 12 hours after chemotherapy infusion on day 1 of cycle 1. Total carboplatin concentrations in plasma and platinum ultrafiltrate were measured. The plasma concentration of free platinum at the end of the infusion was 31,000 ng/ml, and the area under the plasma concentration-time curve was 2.9 minute·mg/ml. No significant carboplatin-related toxicities were reported. This case report indicates that carboplatin can be safely administered in patients receiving hemodialysis.

  14. 47 CFR 15.121 - Scanning receivers and frequency converters used with scanning receivers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; replacing a plug-in semiconductor chip; or programming a semiconductor chip using special access codes or an external device, such as a personal computer. Scanning receivers, and frequency converters designed for...

  15. 47 CFR 15.121 - Scanning receivers and frequency converters used with scanning receivers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; replacing a plug-in semiconductor chip; or programming a semiconductor chip using special access codes or an external device, such as a personal computer. Scanning receivers, and frequency converters designed for...

  16. 47 CFR 15.121 - Scanning receivers and frequency converters used with scanning receivers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...; replacing a plug-in semiconductor chip; or programming a semiconductor chip using special access codes or an external device, such as a personal computer. Scanning receivers, and frequency converters designed for...

  17. 47 CFR 15.121 - Scanning receivers and frequency converters used with scanning receivers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; replacing a plug-in semiconductor chip; or programming a semiconductor chip using special access codes or an external device, such as a personal computer. Scanning receivers, and frequency converters designed for...

  18. 47 CFR 15.121 - Scanning receivers and frequency converters used with scanning receivers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...; replacing a plug-in semiconductor chip; or programming a semiconductor chip using special access codes or an external device, such as a personal computer. Scanning receivers, and frequency converters designed for...

  19. Line Focus Receiver Infrared Temperature Survey System

    SciTech Connect

    Wendelin, Tim

    2010-06-01

    For ongoing maintenance and performance purposes, solar parabolic trough field operators desire to know that the Heat Collection Elements (HCEs) are performing properly. Measuring their temperature is one way of doing this One 30MW field can contain approximately 10,000 HCE's. This software interfaces with a GPS receiver and an infrared camera. It takes global positioning data from the GPS and uses this information to automate the infrared image capture and temperature analysis of individual solar parabolic HCEs in a solar parabolic trough field With this software system an entire 30MW field can be surveyed in 2-3 days.

  20. Reconfigurable Advanced Receiver Design and Implementation

    NASA Technical Reports Server (NTRS)

    Xu, Jianjing

    2005-01-01

    While the demand for real-time broadband information access has grown and continues to grow at a rapid Pace, the need for a reconfigurable receiver system has increased. To achieve the goal to communicate with multiple shuttles at a time, a filter bank in polyphase structure is introduced. This paper presents the design and implementation for high-speed, high-performance, and fixed-point polyphase filter banks. The polyphase filter structure is designed such that the use of a fixed-point system has minimum impact on the performance of the filter. The final hardware implementation is done on a Xilinx FPGA chip.

  1. Thatcher Receives 2004 Charles A. Whitten Medal

    NASA Astrophysics Data System (ADS)

    Stein, Ross

    2005-02-01

    Wayne Thatcher received the Whitten Medal at the 2004 Fall Meeting Honors Ceremony on 15 December, in San Francisco, California. The medal is given for outstanding achievement in research on the form and dynamics of the Earth and planets. Citation. Armed with geodesy, Wayne Thatcher has probed the behavior of great earthquakes, concentrating on the two sites where large events are frequent and the geodetic record is lush: the western United States and Japan. From this, he has garnered deep insights into the earthquake cycle-the pattern of strain accumulation and release of which an earthquake is only the most visible part.

  2. Line Focus Receiver Infrared Temperature Survey System

    2010-06-01

    For ongoing maintenance and performance purposes, solar parabolic trough field operators desire to know that the Heat Collection Elements (HCEs) are performing properly. Measuring their temperature is one way of doing this One 30MW field can contain approximately 10,000 HCE's. This software interfaces with a GPS receiver and an infrared camera. It takes global positioning data from the GPS and uses this information to automate the infrared image capture and temperature analysis of individual solarmore » parabolic HCEs in a solar parabolic trough field With this software system an entire 30MW field can be surveyed in 2-3 days.« less

  3. Advanced motor driven clamped borehole seismic receiver

    DOEpatents

    Engler, Bruce P.; Sleefe, Gerard E.; Striker, Richard P.

    1993-01-01

    A borehole seismic tool including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric meter in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

  4. Advanced motor driven clamped borehole seismic receiver

    DOEpatents

    Engler, B.P.; Sleefe, G.E.; Striker, R.P.

    1993-02-23

    A borehole seismic tool is described including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric motor in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

  5. Solar energy receiver for a Stirling engine

    NASA Technical Reports Server (NTRS)

    Selcuk, M. K. (Inventor)

    1980-01-01

    A solar energy receiver includes a separable endless wall formed of a ceramic material in which a cavity of substantially cylindrical configuration is defined for entrapping solar flux. An acceptance aperture is adapted to admit to the cavity a concentrated beam of solar energy. The wall is characterized by at least one pair of contiguously related segments separated by lines of cleavage intercepting the aperture. At least one of the segments is supported for pivotal displacement. A thermal-responsive actuator is adapted to respond to excessive temperatures within the cavity for initiating pivoted displacement of one segment, whereby thermal flux is permitted to escape from the cavity.

  6. Evaluation of advanced sodium receiver losses during operation of the IEA/SSPS central receiver system

    SciTech Connect

    Carmona, R.; Rosa, F.; Jacobs, H.; Sanchez, M.

    1989-02-01

    This article presents the measurements and experiments conducted on the external receiver: the so-called Advanced Sodium Receiver (ASR) of the Small Solar Power Systems (SSPS) Project of the International Energy Agency (IEA) in southern Spain. The basis of this experiment was to provide loss measurements for later use in determining receiver performance. The tests to evaluate thermal losses consisted in operating the receiver with the doors open and circulating the sodium in normal and reverse flow without providing any incident power from the heliostat field (flux-off technique). In this way, total thermal losses are calculated as the energy lost by the sodium. Radiative losses have been calculated based on theoretical calculations and some results have been compared with infrared thermography measurements. Conductive losses are small and have been estimated by flux-off experiments with the receiver doors closed. Convective losses were evaluated subtracting radiative and conductive losses from the total thermal losses. Optical losses were assessed using absorptance measurements of the receiver coating. A simplified analytical model has been developed to calculate losses and ASR efficiency during operation. In spite of the method's simplicity, the results are very similar to those found by other investigators, verified simulation programs and test results.

  7. Full-wave receiver architecture for the homodyne motion sensor

    SciTech Connect

    Haugen, Peter C; Dallum, Gregory E; Welsh, Patrick A; Romero, Carlos E

    2013-11-19

    A homodyne motion sensor or detector based on ultra-wideband radar utilizes the entire received waveform through implementation of a voltage boosting receiver. The receiver includes a receiver input and a receiver output. A first diode is connected to the receiver output. A first charge storage capacitor is connected from between the first diode and the receiver output to ground. A second charge storage capacitor is connected between the receiver input and the first diode. A second diode is connected from between the second charge storage capacitor and the first diode to ground. The dual diode receiver performs voltage boosting of a RF signal received at the receiver input, thereby enhancing receiver sensitivity.

  8. Full-wave receiver architecture for the homodyne motion sensor

    SciTech Connect

    Haugen, Peter C.; Dallum, Gregory E.; Welsh, Patrick A.; Romero, Carlos E.

    2015-09-29

    A homodyne motion sensor or detector based on ultra-wideband radar utilizes the entire received waveform through implementation of a voltage boosting receiver. The receiver includes a receiver input and a receiver output. A first diode is connected to the receiver output. A first charge storage capacitor is connected from between the first diode and the receiver output to ground. A second charge storage capacitor is connected between the receiver input and the first diode. A second diode is connected from between the second charge storage capacitor and the first diode to ground. The dual diode receiver performs voltage boosting of a RF signal received at the receiver input, thereby enhancing receiver sensitivity.

  9. The 30-GHz monolithic receive module

    NASA Technical Reports Server (NTRS)

    Sokolov, V.; Geddes, J.; Bauhahn, P.

    1983-01-01

    Key requirements for a 30 GHz GaAs monolithic receive module for spaceborne communication antenna feed array applications include an overall receive module noise figure of 5 dB, a 30 dB RF to IF gain with six levels of intermediate gain control, a five-bit phase shifter, and a maximum power consumption of 250 mW. The RF designs for each of the four submodules (low noise amplifier, some gain control, phase shifter, and RF to IF sub-module) are presented. Except for the phase shifter, high frequency, low noise FETs with sub-half micron gate lengths are employed in the submodules. For the gain control, a two stage dual gate FET amplifier is used. The phase shifter is of the passive switched line type and consists of 5-bits. It uses relatively large gate width FETs (with zero drain to source bias) as the switching elements. A 20 GHz local oscillator buffer amplifier, a FET compatible balanced mixer, and a 5-8 GHz IF amplifier constitute the RF/IF sub-module. Phase shifter fabrication using ion implantation and a self-aligned gate technique is described. Preliminary RF results obtained on such phase shifters are included.

  10. Woese on the received view of evolution.

    PubMed

    Sarkar, Sahotra

    2014-01-01

    As part of his attempt to reconstruct the earliest phase of the evolution of life on Earth, Woese produced a compelling critique of the received view of evolution from the 20th century. This paper explicitly articulates two related features of that critique that are fundamental but the first of which has not been sufficiently clearly recognized in the context of evolutionary theorizing: (1) according to Woese's scenario of communal evolution during life's earliest phase (roughly, the first billion years of life on Earth), well-defined biological individuals (and, thus, individual lineages) did not exist; and (2) during that phase, evolutionary change took place through ubiquitous horizontal gene transfer (HGT) rather than through vertical transmission of features (including genes) and the combinatorics of HGT was the dominant mechanism of evolutionary change. Both factors present serious challenges to the received view of evolution and that framework would have to be radically altered to incorporate these factors. The extent to which this will be necessary will depend on whether Woese's scenario of collective early evolution is correct.

  11. Advanced Stirling receiver development program, phase 1

    NASA Technical Reports Server (NTRS)

    Lurio, Charles A.

    1990-01-01

    Critical technology experiments were designed and developed to evaluate the Stirling cavity heat pipe receiver for a space solar power system. Theoretical criteria were applied to the design of a module for containing energy storage phase change material while avoiding thermal ratcheting. Zero-g drop tower tests, without phase change, were conducted to affirm that the bubble location required to avoid ratcheting could be achieved without the use of container materials that are wetted by the phase change material. A full scale module was fabricated, but not tested. A fabrication method was successfully developed for the sodium evaporator dome, with a sintered screen wick, to be used as the focal point for the receiver. Crushing of the screen during hydroforming was substantially reduced over the results of other researchers by using wax impregnation. Superheating of the sodium in the wick under average flux conditions is expected to be under 10K. A 2000K furnace which will simulate solar flux conditions for testing the evaporator dome was successfully built and tested.

  12. Solar central receiver heliostat reflector assembly

    DOEpatents

    Horton, Richard H.; Zdeb, John J.

    1980-01-01

    A heliostat reflector assembly for a solar central receiver system comprises a light-weight, readily assemblable frame which supports a sheet of stretchable reflective material and includes mechanism for selectively applying tension to and positioning the sheet to stretch it to optical flatness. The frame is mounted on and supported by a pipe pedestal assembly that, in turn, is installed in the ground. The frame is controllably driven in a predetermined way by a light-weight drive system so as to be angularly adjustable in both elevation and azimuth to track the sun and efficiently continuously reflect the sun's rays to a focal zone, i.e. central receiver, which forms part of a solar energy utilization system, such as a solar energy fueled electrical power generation system. The frame may include a built-in system for testing for optical flatness of the reflector. The preferable geometric configuration of the reflector is octagonal; however, it may be other shapes, such as hexagonal, pentagonal or square. Several different embodiments of means for tensioning and positioning the reflector to achieve optical flatness are disclosed. The reflector assembly is based on the stretch frame concept which provides an extremely light-weight, simple, low-cost reflector assembly that may be driven for positioning and tracking by a light-weight, inexpensive drive system.

  13. Woese on the received view of evolution

    PubMed Central

    Sarkar, Sahotra

    2014-01-01

    As part of his attempt to reconstruct the earliest phase of the evolution of life on Earth, Woese produced a compelling critique of the received view of evolution from the 20th century. This paper explicitly articulates two related features of that critique that are fundamental but the first of which has not been sufficiently clearly recognized in the context of evolutionary theorizing: (1) according to Woese’s scenario of communal evolution during life’s earliest phase (roughly, the first billion years of life on Earth), well-defined biological individuals (and, thus, individual lineages) did not exist; and (2) during that phase, evolutionary change took place through ubiquitous horizontal gene transfer (HGT) rather than through vertical transmission of features (including genes) and the combinatorics of HGT was the dominant mechanism of evolutionary change. Both factors present serious challenges to the received view of evolution and that framework would have to be radically altered to incorporate these factors. The extent to which this will be necessary will depend on whether Woese’s scenario of collective early evolution is correct. PMID:24572738

  14. Woese on the received view of evolution.

    PubMed

    Sarkar, Sahotra

    2014-01-01

    As part of his attempt to reconstruct the earliest phase of the evolution of life on Earth, Woese produced a compelling critique of the received view of evolution from the 20th century. This paper explicitly articulates two related features of that critique that are fundamental but the first of which has not been sufficiently clearly recognized in the context of evolutionary theorizing: (1) according to Woese's scenario of communal evolution during life's earliest phase (roughly, the first billion years of life on Earth), well-defined biological individuals (and, thus, individual lineages) did not exist; and (2) during that phase, evolutionary change took place through ubiquitous horizontal gene transfer (HGT) rather than through vertical transmission of features (including genes) and the combinatorics of HGT was the dominant mechanism of evolutionary change. Both factors present serious challenges to the received view of evolution and that framework would have to be radically altered to incorporate these factors. The extent to which this will be necessary will depend on whether Woese's scenario of collective early evolution is correct. PMID:24572738

  15. Steam Rankine Solar Receiver, phase 2

    NASA Technical Reports Server (NTRS)

    Deanda, L. E.; Faust, M.

    1981-01-01

    A steam rankine solar receiver (SRSR) based on a tubular concept was designed and developed. The SRSR is an insulated, cylindrical coiled tube boiler which is mounted at the focal plane of a fully tracking parabolic solar reflector. The concentrated solar energy received at the focal plane is then transformed to thermal energy through steam generation. The steam is used in a small Rankine cycle heat engine to drive a generator for the production of electrical energy. The SRSR was designed to have a dual mode capability, performing as a once through boiler with and without reheat. This was achieved by means of two coils which constitute the boiler. The boiler core size of the SRSR is 17.0 inches in diameter and 21.5 inches long. The tube size is 7/16 inch I.D. by 0.070 inch wall for the primary, and 3/4 inch I.D. by 0.125 inch wall for the reheat section. The materials used were corrosion resistant steel (CRES) type 321 and type 347 stainless steel. The core is insulated with 6 inches of cerablanket insulation wrapped around the outer wall. The aperture end and the reflector back plate at the closed end section are made of silicon carbide. The SRSR accepts 85 kwth and has a design life of 10,000 hrs when producing steam at 1400 F and 2550 psig.

  16. Agile multiple aperture imager receiver development

    NASA Astrophysics Data System (ADS)

    Lees, David E. B.; Dillon, Robert F.

    1990-02-01

    A variety of unconventional imaging schemes have been investigated in recent years that rely on small, unphased optical apertures (subaperture) to measure properties of an incoming optical wavefront and recover images of distant objects without using precisely figured, large aperture optical elements. Such schemes offer several attractive features. They provide the potential to create very lare effective aperture that are expandable over time and can be launched into space in small pieces. Since the subapertures are identical in construction, they may be mass producible at potentially low cost. A preliminary design for a practical low cost optical receiver is presented. The multiple aperture design has high sensitivity, wide field-of-view, and is lightweight. A combination of spectral, temporal, and spatial background suppression are used to achieve daytime operation at low signal levels. Modular packaging to make the number of receiver subapertures conveniently scalable is also presented. The design is appropriate to a ground-base proof-of-concept experiment for long range active speckle imaging.

  17. Three Specialized Innovations for FAST Wideband Receiver

    NASA Astrophysics Data System (ADS)

    Zhang, Xia; Yu, Xinying; Duan, Ran; Hao, Jie; Li, Di

    2015-08-01

    The National Astronomical Observatories of the Chinese Academy of Sciences (NAOC) will soon finish the largest antenna in the world. Known as FAST, the Five-hundred-meter Aperture Spherical Radio Telescope will be the most sensitive single-dish radio telescope in the low frequency radio bands between 70 MHz and 3 GHz.To take advantage of its giant aperture, all relevant cutting-edge technology should be applied to FAST to ensure that it achieves the best possible overall performance. The wideband receiver that is currently under development can not only be directly applied to FAST, but also used for other Chinese radio telescopes, such as the Shanghai 65-meter telescope and the Xinjiang 110-meter telescope, to ensure that these telescopes are among the best in the world. Recently, rapid development related to this wideband receiver has been underway. In this paper, we will introduce three key aspects of the FAST wideband receiver project. First is the use of a high-performance analog-to-digital converter (ADC). With the cooperation of Hao Jie’s team from the Institute of Automation of the Chinese Academy of Sciences(CASIA), we have developed 3-Gsps,12-bit ADCs, which have not been used previously in astronomy, and we expect to realize the 3-GHz bandwidth in a single step by covering the entire bandwidth via interleaving or a complex fast Fourier transform (FFT).Second is the front-end analog signal integrated circuit board. We wish to achieve a series of amplification, attenuation, and mixing filtering operations on a single small board, thereby achieving digital control of the bandpass behavior both flexibly and highly-efficiently. This design will not only greatly reduce the required cost and power but will also make the best use of the digital-system’s flexibility. Third is optimization of the FFT: the existing FFT is not very efficient; therefore, we will optimize the FFT for large-scale operation. For this purpose, we intend to cascade two FFTs. Another

  18. Ceramic technology for solar thermal receivers

    NASA Technical Reports Server (NTRS)

    Kudirka, A. A.; Smoak, R. H.

    1981-01-01

    The high-temperature capability, resistance to corrosive environments and non-strategic nature of ceramics have prompted applications in the solar thermal field whose advantages over metallic devices of comparable performance may begin to be assessed. It is shown by a survey of point-focusing receiver designs employing a variety of ceramic compositions and fabrication methods that the state-of-the-art in structural ceramics is not sufficiently advanced to fully realize the promised benefits of higher temperature capabilities at lower cost than metallic alternatives. The ceramics considered include alumina, berylia, magnesia, stabilized zirconia, fused silica, silicon nitride, silicon carbide, mullite and cordierite, processed by such methods as isostatic pressing, dry pressing, slip casting, extrusion, calendaring and injection molding.

  19. Morel Receives 2005 Maurice Ewing Medal

    NASA Astrophysics Data System (ADS)

    Schrag, Daniel P.; Morel, François M. M.

    2006-02-01

    François M. M. Morel received the Ewing Medal at the AGU Fall Meeting Honors Ceremony, which was held on 7 December 2005, in San Francisco, Calif. The medal is given for significant original contributions to the scientific understanding of the processes in the ocean; for the advancement of oceanographic engineering, technology, and instrumentation; and for outstanding service to marine sciences. François Morel has led the search to understand the role of metals in the ocean, starting with a focus on inorganic processes and aquatic chemistry, and leading to a blend of geochemistry, microbiology, biochemistry, and genetics. His influence comes from his research and from the way he has educated an entire community of scientists with his textbooks, with his teaching, and through his former students and postdocs who hold faculty positions at universities throughout the world.

  20. New Packing Structure of Concentration Solar Receiver

    SciTech Connect

    Tsai, Shang-Yu; Lee, Yueh-Mu; Shih, Zun-Hao; Hong, Hwen-Fen; Shin, Hwa-Yuh; Kuo, Cherng-Tsong

    2010-10-14

    This paper presents a solution to the temperature issue in High Concentration Photovoltaic (HCPV) module device by using different thermal conductive material and packing structure. In general, the open-circuited voltage of a device reduces with the increase of temperature and therefore degrades its efficiency. The thermal conductive material we use in this paper, silicon, has a high thermal conductive coefficient (149 W/m{center_dot}K) and steady semiconductor properties which are suitable for the application of solar receiver in HCPV module. Solar cell was soldered on a metal-plated Si substrate with a thicker SiO{sub 2} film which acts as an insulating layer. Then it was mounted on an Al-based plate to obtain a better heat dissipating result.

  1. Modular design of receiver coil arrays.

    PubMed

    De Zanche, Nicola; Massner, Jurek A; Leussler, Christoph; Pruessmann, Klaas P

    2008-07-01

    We describe a modular and hence flexible system for connecting MR surface coils to create a receiver array. Up to 16 individual coils of different size and shape depending on the application are plugged into a connector box that houses the control electronics. Preamplification, matching and detuning circuitry are housed on a circuit board directly attached to each coil loop. Electrical adjustments for tuning or decoupling for each coil configuration are not needed thanks to effective preamplifier decoupling provided through a Pi matching network. Radio-frequency safety and electrically stable cabling are ensured by multiple radio-frequency traps. Array modules for 1.5 and 3 T have been simulated, constructed, tested, and used for imaging experiments.

  2. Sleep Issues with Patients Receiving Hemodialysis.

    PubMed

    Tocco, Kathleen; Rowder, Cheryl; VanNoord, Mary

    2015-01-01

    Poor sleep among the general population is understudied, unrecognized, and often not assessed This is especially true for patients receiving hemodialysis. This study used a case study design to examine the impact of hemodialysis treatments on the sleep of two patients as measured by actigraphy and self-reported sleep logs. Patient 1 experienced an average sleep efficiency of 82.3% on non-hemodialysis days compared to 75.0% on dialysis days, which resulted in a 7.3 percentage point change and 9.7% better sleep efficiency on non-hemodialysis days. Patient 2 reported sleep efficiency 76.6% on non-hemodialysis days compared to 70.5% dialysis on days, resulting in a 6.1 percentage point change and 8.7% better sleep efficiency on non-hemodialysis days. Actigraphy sleep patterns provided an initial move toward best practice for sleep evaluation in this population.

  3. Kopp Receives 2012 William Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Kopp, Robert E.

    2013-10-01

    I have many people to thank for the honor of receiving the William Gilbert Award. Joe Kirschvink must sit at the top of the list, not just for the generosity—I hope at least partially deserved!—of his citation but also for his role as my Ph.D. mentor. During the 5 years I spent working with him at Caltech, Joe was always supportive; was as generous with his time as he has been in his words; and served as a role model for me in the way he fearlessly marched through our planet's history, building bridges between magnetism and our understanding of climate, the biosphere, and the Earth system as a whole.

  4. Remote bistatic receiver synchronization using DLL techniques

    NASA Astrophysics Data System (ADS)

    Aguasca, A.; Broquetas, A.; Fdez de Muniain, J.; Ambros, A.

    An experimental staggered pulse repetition frequency synchronizer, based on a delay-lock loop (DLL) was tested using a transmitter signal simulator that simulates the staggering sequence windowed by the antenna beam. The measured system performance ensures synchronization with a 30-ms direct illumination, with an accumulated delay error in the order of the resolution cell positioning error in range. An artificial time expansion of the received pulses is performed in order to reduce the acquisition time synchronization. A bistatic radar synchronization method based on DLL was is analyzed by linearization of the different parts and signals involved. The parameters that degrade system performance are obtained. And some solutions are represented in order to minimize their effects.

  5. Partitioned-Interval Quantum Optical Communications Receiver

    NASA Technical Reports Server (NTRS)

    Vilnrotter, Victor A.

    2013-01-01

    The proposed quantum receiver in this innovation partitions each binary signal interval into two unequal segments: a short "pre-measurement" segment in the beginning of the symbol interval used to make an initial guess with better probability than 50/50 guessing, and a much longer segment used to make the high-sensitivity signal detection via field-cancellation and photon-counting detection. It was found that by assigning as little as 10% of the total signal energy to the pre-measurement segment, the initial 50/50 guess can be improved to about 70/30, using the best available measurements such as classical coherent or "optimized Kennedy" detection.

  6. Receiver for digital radio broadcasting via satellite

    NASA Astrophysics Data System (ADS)

    Degraaf, C. R.

    1984-10-01

    Quadrature Phase Shift Keying (QPSK) demodulators were investigated; a differential-coherent demodulator (with delay-line) for a 20.48 Mbit/sec and 118 MHz medium frequency was developed. A modified professional coherent demodulator (With Costas-loop carrier wave regaining) (CD), was compared with the DQPSK. At the cost of higher circuit complexity and more adjustings, the CD shows better performances; both demodulators show deviation values 2dB. Applied bit error detection and correction methods were investigated and decoding tables were developed. In cases of high system reserves (e.g., central antenna installations of TV-receiver installations) the cheaper DQPSK is recommended. A prefabricated delay-line (and medium frequency filter) in surface acoustic wave technique is recommended to avoid complicated adjusting procedures.

  7. Sleep Issues with Patients Receiving Hemodialysis.

    PubMed

    Tocco, Kathleen; Rowder, Cheryl; VanNoord, Mary

    2015-01-01

    Poor sleep among the general population is understudied, unrecognized, and often not assessed This is especially true for patients receiving hemodialysis. This study used a case study design to examine the impact of hemodialysis treatments on the sleep of two patients as measured by actigraphy and self-reported sleep logs. Patient 1 experienced an average sleep efficiency of 82.3% on non-hemodialysis days compared to 75.0% on dialysis days, which resulted in a 7.3 percentage point change and 9.7% better sleep efficiency on non-hemodialysis days. Patient 2 reported sleep efficiency 76.6% on non-hemodialysis days compared to 70.5% dialysis on days, resulting in a 6.1 percentage point change and 8.7% better sleep efficiency on non-hemodialysis days. Actigraphy sleep patterns provided an initial move toward best practice for sleep evaluation in this population. PMID:26875228

  8. Listeriosis in patients receiving biologic therapies.

    PubMed

    Bodro, M; Paterson, D L

    2013-09-01

    The evolution of inflammatory diseases has radically changed since the introduction of biologic therapies, such as tumour necrosis factor alpha inhibitors (anti-TNFα). They, therefore, represent a widely used therapeutic modality. Nevertheless, post-marketing studies reveal an increased risk of infection in patients taking these drugs, especially granulomatous infections such as listeriosis. We aimed to evaluate the reported cases of listeriosis in patients treated with biologic treatments. We used the United States Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) from 2004 to 2011. We also perform a literature review of previously reported cases of listeriosis in patients taking biologic therapies. We identified 266 cases of Listeria monocytogenes infection associated with biologic therapies. The majority of patients were receiving infliximab (77.1 %), followed by etanercept (11.7 %), adalimumab (9.8 %), rituximab (4.1 %), abatacept (0.4 %) and golimumab (0.4 %). Indications for the use of biologics were as follows: 47.7 % for rheumatologic diseases, 38 % for inflammatory bowel diseases, 3.4 % for haematological diseases and 10.5 % for other indications. Seventy-three percent of the patients were receiving concomitant immunosuppressant drugs, especially steroids (56 %) and methotrexate (31.6 %). The median time to the onset of infection was 184 days. Mortality rates range from 11.1 % in adalimumab-treated patients to 27.3 % in rituximab-treated patients (p = 0.7). Listeriosis is common in biologics-treated patients, especially related to infliximab use given concomitantly with other immunosuppressive therapies. Infections after treatment with biologics mostly occurred in the first year after initiating treatment. PMID:23568606

  9. Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future.

    PubMed

    Risitano, Antonio M; Marotta, Serena

    2016-06-01

    The introduction in the clinic of anti-complement agents represented a major achievement which gave to physicians a novel etiologic treatment for different human diseases. Indeed, the first anti-complement agent eculizumab has changed the treatment paradigm of paroxysmal nocturnal hemoglobinuria (PNH), dramatically impacting its severe clinical course. In addition, eculizumab is the first agent approved for atypical Hemolytic Uremic Syndrome (aHUS), a life-threatening inherited thrombotic microangiopathy. Nevertheless, such remarkable milestone in medicine has brought to the fore additional challenges for the scientific community. Indeed, the list of complement-mediated anemias is not limited to PNH and aHUS, and other human diseases can be considered for anti-complement treatment. They include other thrombotic microangiopathies, as well as some antibody-mediated hemolytic anemias. Furthermore, more than ten years of experience with eculizumab led to a better understanding of the individual steps of the complement cascade involved in the pathophysiology of different human diseases. Based on this, new unmet clinical needs are emerging; a number of different strategies are currently under development to improve current anti-complement treatment, trying to address these specific clinical needs. They include: (i) alternative anti-C5 agents, which may improve the heaviness of eculizumab treatment; (ii) broad-spectrum anti-C3 agents, which may improve the efficacy of anti-C5 treatment by intercepting the complement cascade upstream (i.e., preventing C3-mediated extravascular hemolysis in PNH); (iii) targeted inhibitors of selective complement activating pathways, which may prevent early pathogenic events of specific human diseases (e.g., anti-classical pathway for antibody-mediated anemias, or anti-alternative pathway for PNH and aHUS). Here we briefly summarize the status of art of current and future complement inhibition for different complement-mediated anemias

  10. 47 CFR 15.117 - TV broadcast receivers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false TV broadcast receivers. 15.117 Section 15.117... TV broadcast receivers. (a) All TV broadcast receivers shipped in interstate commerce or imported... receivers also includes devices, such as TV interface devices and set-top devices that are intended...

  11. 47 CFR 15.117 - TV broadcast receivers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false TV broadcast receivers. 15.117 Section 15.117... TV broadcast receivers. (a) All TV broadcast receivers shipped in interstate commerce or imported... receivers also includes devices, such as TV interface devices and set-top devices that are intended...

  12. 47 CFR 15.117 - TV broadcast receivers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false TV broadcast receivers. 15.117 Section 15.117... TV broadcast receivers. (a) All TV broadcast receivers shipped in interstate commerce or imported... receivers also includes devices, such as TV interface devices and set-top devices that are intended...

  13. Integrated Submm Wave Receiver: Development and Applications

    NASA Astrophysics Data System (ADS)

    Koshelets, Valery P.; Birk, Manfred; Boersma, Dick; Dercksen, Johannes; Dmitriev, Pavel; Ermakov, Andrey B.; Filippenko, Lyudmila V.; Golstein, Hans; Hoogeveen, Ruud W. M.; de Jong, Leo; Khudchenko, Andrey V.; Kinev, Nickolay V.; Kiselev, Oleg S.; Kudryashov, Pavel V.; Van Kuik, Bart; de Lange, Arno; de Lange, Gert; L. Lapitsky, Irina; I. Pripolzin, Sergey; van Rantwijk, Joris; Selig, Avri M.; Sobolev, Alexander S.; Torgashin, Mikhail Yu; Vaks, Vladimir L.; de Vries, Ed; Wagner, Georg; Yagoubov, Pavel A.

    A superconducting integrated receiver (SIR) comprises in a single chip a planar antenna combined with a superconductor-insulator-superconductor (SIS) mixer, a superconducting Flux Flow Oscillator (FFO) acting as a Local Oscillator (LO) and a second SIS harmonic mixer (HM) for the FFO phase locking. In this report, an overview of the SIR and FFO developments and optimizations is presented. Improving on the fully Nb-based SIR we have developed and studied Nb-AlN-NbN circuits, which exhibit an extended operation frequency range. Continuous tuning of the phase locked frequency has been experimentally demonstrated at any frequency in the range 350-750 GHz. The FFO free-running linewidth has been measured between 1 and 5 MHz, which allows to phase lock up to 97% of the emitted FFO power. The output power of the FFO is sufficient to pump the matched SIS mixer. Therefore, it is concluded that the Nb-AlN-NbN FFOs are mature enough for practical applications.These achievements enabled the development of a 480-650 GHz integrated receiver for the atmospheric-research instrument TErahertz and submillimeter LImb Sounder (TELIS). This balloon-borne instrument is a three-channel superconducting heterodyne spectrometer for the detection of spectral emission lines of stratospheric trace gases that have their rotational transitions at THz frequencies. One of the channels is based on the SIR technology. We demonstrate for the first time the capabilities of the SIR technology for heterodyne spectroscopy in general, and atmospheric limb sounding in particular. We also show that the application of SIR technology is not limited to laboratory environments, but that it is well suited for remote operation under harsh environmental conditions. Light weight and low power consumption combined with broadband operation and nearly quantum limited sensitivity make the SIR a perfect candidate for future airborne and space-borne missions. The noise temperature of the SIR was measured to be as low as

  14. Animal choruses emerge from receiver psychology

    PubMed Central

    Greenfield, Michael D.; Esquer-Garrigos, Yareli; Streiff, Réjane; Party, Virginie

    2016-01-01

    Synchrony and alternation in large animal choruses are often viewed as adaptations by which cooperating males increase their attractiveness to females or evade predators. Alternatively, these seemingly composed productions may simply emerge by default from the receiver psychology of mate choice. This second, emergent property hypothesis has been inferred from findings that females in various acoustic species ignore male calls that follow a neighbor’s by a brief interval, that males often adjust the timing of their call rhythm and reduce the incidence of ineffective, following calls, and from simulations modeling the collective outcome of male adjustments. However, the purported connection between male song timing and female preference has never been tested experimentally, and the emergent property hypothesis has remained speculative. Studying a distinctive katydid species genetically structured as isolated populations, we conducted a comparative phylogenetic analysis of the correlation between male call timing and female preference. We report that across 17 sampled populations male adjustments match the interval over which females prefer leading calls; moreover, this correlation holds after correction for phylogenetic signal. Our study is the first demonstration that male adjustments coevolved with female preferences and thereby confirms the critical link in the emergent property model of chorus evolution. PMID:27670673

  15. Social Interactions Receive Priority to Conscious Perception.

    PubMed

    Su, Junzhu; van Boxtel, Jeroen J A; Lu, Hongjing

    2016-01-01

    Humans are social animals, constantly engaged with other people. The importance of social thought and action is hard to overstate. However, is social information so important that it actually determines which stimuli are promoted to conscious experience and which stimuli are suppressed as invisible? To address this question, we used a binocular rivalry paradigm, in which the two eyes receive different action stimuli. In two experiments we measured the conscious percept of rival actions and found that actions engaged in social interactions are granted preferential access to visual awareness over non-interactive actions. Lastly, an attentional task that presumably engaged the mentalizing system enhanced the priority assigned to social interactions in reaching conscious perception. We also found a positive correlation between human identification of interactive activity and the promotion of socially-relevant information to visual awareness. The present findings suggest that the visual system amplifies socially-relevant sensory information and actively promotes it to consciousness, thereby facilitating inferences about social interactions. PMID:27509028

  16. Harrison Receives 2006 William Gilbert Award

    NASA Astrophysics Data System (ADS)

    McEnroe, Suzanne A.; Harrison, Richard J.

    2007-04-01

    Richard J. Harrison received the William Gilbert Award at the 2006 AGU Fall Meeting. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets. This year the Gilbert Award is given to an outstanding young scientist under the age of 35. Richard Harrison easily fulfills the first criterion and just makes the second. He is now 34. As I reviewed Richard's accomplishments, I was once again impressed with his scope and level of research. He has 50 papers published, or in press, and all of them are of the same high scientific caliber. Many of you know Richard's cutting-edge research with electron holography showing magnetic interactions across magnetite-ulvospinel intergrowths, and are familiar with his groundbreaking research on lamellar magnetism. His TEM observations, combined with extensive Monte Carlo simulations of atomic interactions in hematite-ilmenite interfaces, which took both electrostatic and magnetic interactions into consideration, have developed the idea of contact layers as a magnetic substructure of defect moments at the interfaces. This was followed by work that showed that contact layers reduce charge imbalance at the interfaces.

  17. Social Interactions Receive Priority to Conscious Perception

    PubMed Central

    Su, Junzhu; van Boxtel, Jeroen J. A.; Lu, Hongjing

    2016-01-01

    Humans are social animals, constantly engaged with other people. The importance of social thought and action is hard to overstate. However, is social information so important that it actually determines which stimuli are promoted to conscious experience and which stimuli are suppressed as invisible? To address this question, we used a binocular rivalry paradigm, in which the two eyes receive different action stimuli. In two experiments we measured the conscious percept of rival actions and found that actions engaged in social interactions are granted preferential access to visual awareness over non-interactive actions. Lastly, an attentional task that presumably engaged the mentalizing system enhanced the priority assigned to social interactions in reaching conscious perception. We also found a positive correlation between human identification of interactive activity and the promotion of socially-relevant information to visual awareness. The present findings suggest that the visual system amplifies socially-relevant sensory information and actively promotes it to consciousness, thereby facilitating inferences about social interactions. PMID:27509028

  18. Dish stirling solar receiver combustor test program

    NASA Technical Reports Server (NTRS)

    Bankston, C. P.; Back, L. H.

    1981-01-01

    The operational and energy transfer characteristics of the Dish Stirling Solar Receiver (DSSR) combustor/heat exchanger system was evaluated. The DSSR is designed to operate with fossil fuel augmentation utilizing a swirl combustor and cross flow heat exchanger consisting of a single row of 4 closely spaced tubes that are curved into a conical shape. The performance of the combustor/heat exchanger system without a Stirling engine was studied over a range of operating conditions and output levels using water as the working fluid. Results show that the combustor may be started under cold conditions, controlled safety, and operated at a constant air/fuel ratio (10 percent excess air) over the required range of firing rates. Furthermore, nondimensional heat transfer coefficients based on total heat transfer are plotted versus Reynolds number and compared with literature data taken for single rows of closely spaced tubes perpendicular to cross flow. The data show enhanced heat transfer for the present geometry and test conditions. Analysis of the results shows that the present system meets specified thermal requirements, thus verifying the feasibility of the DSSR combustor design for final prototype fabrication.

  19. 41 CFR 302-6.16 - May I receive a TQSE allowance if I am receiving another subsistence expenses allowance?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false May I receive a TQSE allowance if I am receiving another subsistence expenses allowance? 302-6.16 Section 302-6.16 Public... SUBSISTENCE EXPENSES General Rules § 302-6.16 May I receive a TQSE allowance if I am receiving...

  20. Turcotte Receives 2003 William Bowie Medal

    NASA Astrophysics Data System (ADS)

    Cathles, Lawrence M.; Turcotte, Donald L.

    2004-01-01

    ``Few have contributed more to fundamental geophysics, or been better at encouraging others to contribute, than Donald L. Turcotte. Don trained as an engineer, receiving a Ph.D. in Aeronautics and Physics from the California Institute of Technology in 1958. After a year at the Naval Postgraduate School in Monterey, he joined the Cornell Graduate School of Aeronautical Engineering, rising to full professor. He established expertise on seeded combustion, magnetohydrodynamic and electrical phenomena in turbulent boundary layers, and shock waves and authored a book, Space Propulsion, and co-authored a textbook, Statistical Thermodynamics. ``In 1965 he went on sabbatical to Oxford and returned an Earth scientist. The catalyst was Ron Oxburgh. Plate tectonics was just on the horizon, and Don joined his quantitative abilities and physical intuition with Ron's skills and knowledge of geology to produce over the next decade a remarkable series of 24 papers that explored topics such as the many implications of the Earth's thermal boundary layer, ridge melting, subduction zone volcanism, and intraplate tectonics and magmatism, and established the physical bases for many of the processes operating on our planet. Shifting to the Cornell Department of Geological Sciences in 1973, Don explored virtually every aspect of physical Earth geology and became an expert on planetary remote sensing and geophysical interpretation. He published over 150 papers on thermal subsidence in sedimentary basins, two-phase hydrothermal porous media convection, lithosphere flexure, cyclic sedimentation, and stick-slip earthquakes and the lithospheres and mantles of the other planets. He worked and published with outstanding students and colleagues including Ken Torrance, Gerald Schubert, David Spence, Marc Parmentier, Bill Haxby, John Ockendon, Kevin Burke, Jud Ahern, Steve Emerman, and Charlie Angevine. In 1982 he published Geodynamics with Jerry Schubert, a book that became the primary reference in

  1. Hypocupremia in patients receiving total parenteral nutrition.

    PubMed

    Bozzetti, F; Inglese, M G; Terno, G; Pupa, A; Sequeira, C; Migliavacca, S

    1983-01-01

    Although hypocupremia is a well-known consequence of long-term total parenteral nutrition (TPN), its incidence as well as the duration of TPN necessary to induce it are still unsettled. The purpose of this study is to review the changes in serum copper level in 25 patients receiving TPN for a period longer than 2 wk (mean duration 6 wk) at the Istituto Nazionale Tumori of Milan and to evaluate the possible relationship of cupremia with the basic disease. Main indications for TPN included enterocutaneous fistulas (11 patients), cancer cachexia (10 patients), radiation enteropathy (two patients), and severe postoperative stricture following esophagogastric resection (two patients). Mean value of serum copper at the beginning of the study was 143 micrograms/100 ml (normal value 65-165 micrograms/100 ml), and the regression analysis showed a mean fall of 5.64 micrograms/100 ml/wk. Hypocupremia occurred in four patients (three with intestinal fistulas and one with radiation obstructive enteritis) at 5th, 6th, 9th, and 6th wk of TPN, respectively. No patient with cancer cachexia developed hypocupremia. No patient with hypocupremia had clinical evidence of a copper deficiency syndrome. We conclude that 1) hypocupremia does not occur within the first month of TPN; 2) its incidence is about 16% in patients intravenously fed for period longer than 2 wk; 3) it is more frequent in patients with enterocutaneous fistulas, whereas it never occurs in patients with cancer cachexia, and 4) it is not necessarily associated to a clinicometabolic syndrome of copper deficiency. Finally, the "nutritional" meaning of serum copper should be questioned in cancer patients since it could represent a "tumor marker."

  2. Social effects of migration in receiving countries.

    PubMed

    Bergman, E

    1989-06-01

    Using a theoretical approach, this paper discusses the treatment of different aspects of the social effects of migration in receiving countries which centers around key issues such as ethnicity, discrimination, and the impact of general policy measures upon ethnic relations. Countries may be classified with respect to relations between ethnic groups in the following ways: 1) those that are either plural or multi-ethnic, 2) those consisting of mainly immigrants and their offspring, 3) those that have a fairly homogenous population and ethnic minorities resulting from post-war immigration, and 4) those that have a fairly homogenous population and 1 or more native minorities. International migration requires nations to formulate immigration, immigrant, and ethnic relations policies. Ethnic conflict often stems from a situation of need within competition for such facilities as education, housing, and employment. The underlying factors are mostly economic. The unequal distribution of influence and resources can be reduced by government policies designed to redistribute such influence and resources, and by providing better opportunities for individuals to gain influence and resources. Policy measures in the fields of general economic policy, labor market policy, housing policy, social policy, and educational policy probably affect ethnic relations more deeply than measures in the field of ethnic relations policy. Discrimination on ethnic, racial, or similar grounds is against the constitution of many countries. However, many difficulties arise in trying to use anti-discrimination laws in practice. Ethnicity is probably the most widespread cause of conflict in the world. The ethnic homogeneity of many countries has been reduced by the immigration of new ethnic elements. Can truly multicultural societies emerge from international migration? 3 possibilities exist: 1) unitary social systems will prevail where they 1st existed, 2) ethnic groups may segregate from each other

  3. Receiver concepts for data transmission at 10 microns

    NASA Astrophysics Data System (ADS)

    Scholtz, A. L.; Philipp, H. K.; Leeb, W. R.

    1984-05-01

    Receivers for digitally modulated CO2 laser signals are compared. Incoherent heterodyne receivers and coherent homodyne setups, including the linear phase locked loop (PLL) receiver, the low intermediate frequency translation loop, and the Costas loop receiver were studied. Experiments covered the homodyne systems, emphasizing the linear PLL receiver. Reliable phase lock of the receiver is achieved at carrier levels as low as 3 nW. Reception of signals phase shift keyed with a data rate of up to 150 Mbit/sec is demonstrated at subnanowatt sideband power levels.

  4. Testing (HIV). Quick test receives Singapore approval.

    PubMed

    1996-04-22

    Hema-Strip HIV 1/2 is a rapid HIV antibody immunoassay developed by Saliva Diagnostic Systems, Inc. (SDS) which can be used by anyone who can read the product insert. The test kit is comprised of a small lancet for a finger stick, a cylindrical tube with a capillary tip and a SDS diagnostic strip inside, and a vial of buffer. Once blood is drawn by the lancet, the capillary tip is placed upon the blood droplet and the blood is automatically drawn into the tube. The tube is then inserted tip first into the vial of buffer. The buffer and blood migrate over the diagnostic strip inside, yielding stable results within 15 minutes. Studies have found Hema-Strip HIV 1/2 to have a sensitivity and specificity greater than 99.4%, as accurate as most conventional HIV tests which require the use of laboratory equipment and trained staff, and possibly hours to produce results. Moreover, the test kit requires neither refrigeration nor special storage. Hema-Strip HIV 1/2 has received a certificate of free sale from the Ministry of Health in Singapore and is now being submitted for regulatory approval in Brazil, China, Russia, India, Malaysia, Thailand, and the UK. SDS products in production include Sero-Strip HIV 1/2, a rapid serum-based HIV antibody test; Omni-SAL, a saliva collector which is the principal sample collection device used by British insurance companies for HIV testing with other confirmatory tests; Omni-Swab, a serrated swab which collects body fluids or cells; Saliva-Sampler, a saliva collection device used for general testing purposes; and Saliva Check, a test which checks the composition of saliva samples. SDS is in the final stages of developing Saliva-Strip HIV-1/2, a rapid saliva-based HIV antibody test. The company also intends to complete development in 1996 of a rapid blood-based antibody test for the Helicobacter pylori bacteria, a pathogen linked to 80% of peptic ulcers and gastric cancers. PMID:12290908

  5. 47 CFR 32.6790 - Provision for uncollectible notes receivable.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions for Expense Accounts § 32.6790 Provision for uncollectible notes receivable. This account shall be charged with amounts concurrently credited to Account 1170, Receivables....

  6. 3. DETAIL OF ORE RECEIVING PLATFORM AND GRIZZLY, VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. DETAIL OF ORE RECEIVING PLATFORM AND GRIZZLY, VIEW TO WEST. - Vanadium Corporation of America (VCA) Naturita Mill, Sampling Building & Ore Receiving Platform, 3 miles Northwest of Naturita, between Highway 141 & San Miguel River, Naturita, Montrose County, CO

  7. 1. VIEW TO SOUTH (RETAINING WALL OF ORE RECEIVING PLATFORM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW TO SOUTH (RETAINING WALL OF ORE RECEIVING PLATFORM TO LEFT). - Vanadium Corporation of America (VCA) Naturita Mill, Sampling Building & Ore Receiving Platform, 3 miles Northwest of Naturita, between Highway 141 & San Miguel River, Naturita, Montrose County, CO

  8. 2. VIEW TO NORTHEAST (ORE RECEIVING PLATFORM OUT OF VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW TO NORTHEAST (ORE RECEIVING PLATFORM OUT OF VIEW TO RIGHT). - Vanadium Corporation of America (VCA) Naturita Mill, Sampling Building & Ore Receiving Platform, 3 miles Northwest of Naturita, between Highway 141 & San Miguel River, Naturita, Montrose County, CO

  9. 4. DETAIL OF ORE RECEIVING PLATFORM AND GRIZZLY, VIEW TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. DETAIL OF ORE RECEIVING PLATFORM AND GRIZZLY, VIEW TO EAST. - Vanadium Corporation of America (VCA) Naturita Mill, Sampling Building & Ore Receiving Platform, 3 miles Northwest of Naturita, between Highway 141 & San Miguel River, Naturita, Montrose County, CO

  10. Percentage of Adults Who Receive Colorectal Cancer Screening as Appropriate

    MedlinePlus

    ... Appropriate Percentage of Adults Who Receive Colorectal Cancer Screening as Appropriate Colorectal cancer is the second leading ... Percentage of Adults Who Receive Recommended Colorectal Cancer Screening by Age Group 78pm-ubty Download these data » ...

  11. 47 CFR 15.117 - TV broadcast receivers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... sensitivity of a TV broadcast receiver averaged for all channels between 14 and 69 inclusive shall not be more than 8dB larger than the peak picture sensitivity of that receiver averaged for all channels between...

  12. Processing In A GPS Receiver To Reduce Multipath Errors

    NASA Technical Reports Server (NTRS)

    Meehan, Thomas K.

    1994-01-01

    Four techniques of ancillary real-time digital processing of signals in Global Positioning System, GPS, receiver introduced reducing effects of multipath propagation of signals on position estimates produced by receiver. Multipath range errors halved. Applied in addition to other signal-processing techniques and to other techniques designing as receiving antenna to make it insensitive to reflections of GPS signals from nearby objects.

  13. Communications Satellite Receiver Systems for Public Schools: A Technical Primer.

    ERIC Educational Resources Information Center

    Texas Education Agency, Austin.

    Designed to aid school districts contemplating use of some of the telecommunications services now available by satellite, this document contains information on home satellite receiving dishes (Television Receive-Only--TVROs), which can receive radio signals carrying television, sound, and data. This information includes: some factors involved in…

  14. 30 CFR 56.13011 - Air receiver tanks.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Air receiver tanks. 56.13011 Section 56.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more automatic...

  15. 30 CFR 56.13011 - Air receiver tanks.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Air receiver tanks. 56.13011 Section 56.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more automatic...

  16. 30 CFR 57.13011 - Air receiver tanks.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Air receiver tanks. 57.13011 Section 57.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more...

  17. 30 CFR 57.13011 - Air receiver tanks.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Air receiver tanks. 57.13011 Section 57.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air and Boilers § 57.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more...

  18. 30 CFR 56.13011 - Air receiver tanks.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Air receiver tanks. 56.13011 Section 56.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Compressed Air and Boilers § 56.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more automatic...

  19. An organic Rankine receiver for the SCSTPE program

    NASA Technical Reports Server (NTRS)

    Osborn, D. B.

    1980-01-01

    The organic Rankine cycle receiver which is presently being developed is described. The receiver employs an integrated cavity/pool boiler which permits the design of a small, lightweight, low cost and efficient moderate temperature receiver for use in a dish-Rankine solar thermal system.

  20. 47 CFR 80.290 - Auxiliary receiving antenna.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not...

  1. 47 CFR 80.290 - Auxiliary receiving antenna.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not...

  2. 47 CFR 80.290 - Auxiliary receiving antenna.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not...

  3. 47 CFR 80.290 - Auxiliary receiving antenna.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not...

  4. 47 CFR 80.290 - Auxiliary receiving antenna.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not...

  5. 24 CFR 982.355 - Portability: Administration by receiving PHA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... terminate assistance for family action or inaction in accordance with §§ 982.552 and 982.553. (d) Absorption... receiving PHA voucher program. After absorption, the family is assisted with funds available under the... units) to the receiving PHA for absorption of portable families. (4) HUD may require the receiving...

  6. 26 CFR 1.1502-26 - Consolidated dividends received deduction.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 12 2011-04-01 2011-04-01 false Consolidated dividends received deduction. 1... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Computation of Consolidated Items § 1.1502-26 Consolidated dividends received deduction. (a) In general. (1) The consolidated dividends received...

  7. 26 CFR 1.1502-26 - Consolidated dividends received deduction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Consolidated dividends received deduction. 1... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Computation of Consolidated Items § 1.1502-26 Consolidated dividends received deduction. (a) In general. (1) The consolidated dividends received deduction for...

  8. 49 CFR 220.33 - Receiving a radio transmission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Receiving a radio transmission. 220.33 Section 220... § 220.33 Receiving a radio transmission. (a) Upon receiving a radio call, an employee shall promptly... a transmission shall repeat it to the transmitting party unless the communication: (1) Relates...

  9. 49 CFR 220.33 - Receiving a radio transmission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Receiving a radio transmission. 220.33 Section 220... § 220.33 Receiving a radio transmission. (a) Upon receiving a radio call, an employee shall promptly... a transmission shall repeat it to the transmitting party unless the communication: (1) Relates...

  10. 5 CFR 551.425 - Time spent receiving medical attention.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Time spent receiving medical attention... Relation to Other Activities § 551.425 Time spent receiving medical attention. (a) Time spent waiting for and receiving medical attention for illness or injury shall be considered hours of work if: (1)...

  11. 49 CFR 236.555 - Repaired or rewound receiver coil.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Repaired or rewound receiver coil. 236.555 Section 236.555 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... or rewound receiver coil. Receiver coil which has been repaired or rewound shall have the...

  12. 49 CFR 236.555 - Repaired or rewound receiver coil.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Repaired or rewound receiver coil. 236.555 Section 236.555 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... or rewound receiver coil. Receiver coil which has been repaired or rewound shall have the...

  13. 49 CFR 220.33 - Receiving a radio transmission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Receiving a radio transmission. 220.33 Section 220... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD COMMUNICATIONS Radio and Wireless Communication Procedures § 220.33 Receiving a radio transmission. (a) Upon receiving a radio call, an employee shall...

  14. Micropower RF transponder with superregenerative receiver and RF receiver with sampling mixer

    DOEpatents

    McEwan, Thomas E.

    1997-01-01

    A micropower RF transdponder employs a novel adaptation of the superregenerative receiver wherein the quench oscillator is external to the regenerative transistor. The quench oscillator applies an exponentially decaying waveform rather than the usual sinewave to achieve high sensitivity at microampere current levels. Further improvements include circuit simplifications for antenna coupling, extraction of the detected signal, and a low-voltage bias configuration that allows operation with less than a 1-volt rail voltage. The inventive transponder is expected to operate as long as the battery shelf life.

  15. Micropower RF transponder with superregenerative receiver and RF receiver with sampling mixer

    DOEpatents

    McEwan, T.E.

    1997-05-13

    A micropower RF transponder employs a novel adaptation of the superregenerative receiver wherein the quench oscillator is external to the regenerative transistor. The quench oscillator applies an exponentially decaying waveform rather than the usual sinewave to achieve high sensitivity at microampere current levels. Further improvements include circuit simplifications for antenna coupling, extraction of the detected signal, and a low-voltage bias configuration that allows operation with less than a 1-volt rail voltage. The inventive transponder is expected to operate as long as the battery shelf life. 13 figs.

  16. Moments Of Microdiversity EGC Receivers And Macrodiversity SC Receiver Output Signal Over Gamma Shadowed Nakagami-m Multipath Fading Channel

    NASA Astrophysics Data System (ADS)

    Djordjević, Nebojša; Jaksić, Branimir S.; Matović, Ana; Matović, Marija; Smilić, Marko

    2015-11-01

    A system with macrodiversity selection combining (SC) receiver and for microdiversity equal gain combining (EGC) receivers is considered. Received signal is subjected, simultaneously to multipath fading and shadowing, resulting in signal envelope and signal power variation. Closed form expressions for moments of macrodiversity SC receiver output signal envelope are calculated. Numerical expressions are plotted to present the influences of Gamma shadowing severity and Nakagami-m severity on moments of proposed system output signal.

  17. Spread Spectrum Receiver Electromagnetic Interference (EMI) Test Guide

    NASA Technical Reports Server (NTRS)

    Wheeler, Mark L.

    1998-01-01

    This program consisted of: (1) a study to define appropriate EMI test guidelines and test methods for direct sequence (DS) spread spectrum receivers; and (2) preparation of a written test guide to document the recommended test methods. The scope of this test guide includes: (1) a discussion of generic DS receiver performance characteristics; (2) a summary of S-band TDRSS receiver operation; (3) a discussion of DS receiver EMI susceptibility mechanisms and characteristics; (4) a summary of military standard test guidelines; (5) recommended test approach and methods; and (6) general conclusions and recommendations for future studies in the area of spread spectrum receiver testing.

  18. Hybrid lidar radar receiver for underwater imaging applications

    NASA Astrophysics Data System (ADS)

    Seetamraju, Madhavi; Gurjar, Rajan; Squillante, Michael; Derderian, Jeffrey P.

    2009-05-01

    In this work, we present research performed to improve the receiver characteristics for underwater imaging applications using the hybrid lidar-radar detection technique. We report the development of the next-generation coherent heterodyne receiver using modulation of the optical receiver's amplifier gain. Significant advantages in the receiver specifications are achieved using a large-area, high gain, low-noise silicon avalanche photodiode (APD) as the photodetector cum frequency mixer-demodulator. We demonstrate that heterodyne detection by gain modulation of APD can be used to increase the signal-to-noise ratio, detection sensitivity and bandwidth for the hybrid receiver system.

  19. Ultracompact 100 Gbps coherent receiver monolithically integrated on silicon

    NASA Astrophysics Data System (ADS)

    Tu, Zhijuan; Gong, Pan; Zhou, Zhiping; Wang, Xingjun

    2016-04-01

    This work describes an ultracompact coherent receiver monolithically integrated on silicon. The coherent receiver integrates one 1D grating coupler, one 2D grating coupler, two 90° hybrids, and eight Ge photodetectors in an area of only 1.3 × 1.4 mm2, which is about half the size of the smallest previously reported receiver. The design and performances of the components and the integrated coherent receiver are presented. The receiving of 100 Gbps polarization-division-multiplexed quadrature phase-shift keying (PDM-QPSK) signals is also successfully demonstrated.

  20. Multistage estimation of received carrier signal parameters under very high dynamic conditions of the receiver

    NASA Technical Reports Server (NTRS)

    Kumar, Rajendra (Inventor)

    1990-01-01

    A multistage estimator is provided for the parameters of a received carrier signal possibly phase-modulated by unknown data and experiencing very high Doppler, Doppler rate, etc., as may arise, for example, in the case of Global Positioning Systems (GPS) where the signal parameters are directly related to the position, velocity and jerk of the GPS ground-based receiver. In a two-stage embodiment of the more general multistage scheme, the first stage, selected to be a modified least squares algorithm referred to as differential least squares (DLS), operates as a coarse estimator resulting in higher rms estimation errors but with a relatively small probability of the frequency estimation error exceeding one-half of the sampling frequency, provides relatively coarse estimates of the frequency and its derivatives. The second stage of the estimator, an extended Kalman filter (EKF), operates on the error signal available from the first stage refining the overall estimates of the phase along with a more refined estimate of frequency as well and in the process also reduces the number of cycle slips.

  1. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume III. Appendices

    SciTech Connect

    1980-01-01

    The overall, long term objective of the Solar Central Receiver Hybrid Power System is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumpton, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume contains appendices to the conceptual design and systems analysis studies gien in Volume II, Books 1 and 2. (WHK)

  2. Multistage estimation of received carrier signal parameters under very high dynamic conditions of the receiver

    NASA Technical Reports Server (NTRS)

    Kumar, Rajendra (Inventor)

    1991-01-01

    A multistage estimator is provided for the parameters of a received carrier signal possibly phase-modulated by unknown data and experiencing very high Doppler, Doppler rate, etc., as may arise, for example, in the case of Global Positioning Systems (GPS) where the signal parameters are directly related to the position, velocity and jerk of the GPS ground-based receiver. In a two-stage embodiment of the more general multistage scheme, the first stage, selected to be a modified least squares algorithm referred to as differential least squares (DLS), operates as a coarse estimator resulting in higher rms estimation errors but with a relatively small probability of the frequency estimation error exceeding one-half of the sampling frequency, provides relatively coarse estimates of the frequency and its derivatives. The second stage of the estimator, an extended Kalman filter (EKF), operates on the error signal available from the first stage refining the overall estimates of the phase along with a more refined estimate of frequency as well and in the process also reduces the number of cycle slips.

  3. Effect of High Receiver Thermal Loss Per Unit Area on the Performance of Solar Central Receiver Systems Having Optimum Heliostat Fields and Optimum Receiver Aperture Areas.

    NASA Astrophysics Data System (ADS)

    Pitman, Charles L.

    Recent efforts in solar central receiver research have been directed toward high temperature applications. Associated with high temperature processes are greater receiver thermal losses due to reradiation and convection. This dissertation examines the performance of central receiver systems having optimum heliostate fields and receiver aperture areas as a function of receiver thermal loss per unit area of receiver aperture. The results address the problem of application optimization (loss varies) as opposed to the problem of optimization of a design for a specific application (loss fixed). A reasonable range of values for the primary independent variable L (the average reradiative and convective loss per unit area of receiver aperture) and a reasonable set of design assumptions were first established. The optimum receiver aperture area, number and spacings of heliostats, and field boundary were then determined for two tower focal heights and for each value of L. From this, the solar subsystem performance for each optimized system was calculated. Heliostat field analysis and optimization required a detailed computational analysis. A significant modification to the standard method of solving the optimization equations, effectively a decoupling of the solution process into collector and receiver subsystem parts, greatly aided the analysis. Results are presented for tower focal heights of 150 and 180 m. Values of L ranging from 0.04 to 0.50 MW m('-2) were considered, roughly corresponding to working fluid temperatures (at receiver exit) in the range of 650 to 1650 C. As L increases over this range, the receiver thermal efficiency and the receiver interception factor decrease. The optimal power level drops by almost half, and the cost per unit of energy produced increases by about 25% for the base case set of design assumptions. The resulting decrease in solar subsystem efficiency (relative to the defined annual input energy) from 0.57 to 0.35 is about 40% and is a

  4. A pseudolite-based positioning system for legacy GNSS receivers.

    PubMed

    Kim, Chongwon; So, Hyoungmin; Lee, Taikjin; Kee, Changdon

    2014-03-27

    The ephemeris data format of legacy GPS receivers is improper for positioning stationary pseudolites on the ground. Therefore, to utilize pseudolites for navigation, GPS receivers must be modified so that they can handle the modified data formats of the pseudolites. Because of this problem, the practical use of pseudolites has so far been limited. This paper proposes a pseudolite-based positioning system that can be used with unmodified legacy GPS receivers. In the proposed system, pseudolites transmit simulated GPS signals. The signals use standard GPS ephemeris data format and contain ephemeris data of simulated GPS satellites, not those of pseudolites. The use of the standard format enables the GPS receiver to process pseudolite signals without any modification. However, the position output of the GPS receiver is not the correct position in this system, because there are additional signal delays from each pseudolite to the receiver. A post-calculation process was added to obtain the correct receiver position using GPS receiver output. This re-estimation is possible because it is based on known information about the simulated signals, pseudolites, and positioning process of the GPS receiver. Simulations using generated data and live GPS data are conducted for various geometries to verify the proposed system. The test results show that the proposed system provides the desired user position using pseudolite signals without requiring any modifications to the legacy GPS receiver. In this initial study, a pseudolite-only indoor system was assumed. However, it can be expanded to a GPS-pseudolite system outdoors.

  5. Development of a digital receiver for range imaging atmospheric radar

    NASA Astrophysics Data System (ADS)

    Yamamoto, Masayuki K.; Fujita, Toshiyuki; Abdul Aziz, Noor Hafizah Binti; Gan, Tong; Hashiguchi, Hiroyuki; Yu, Tian-You; Yamamoto, Mamoru

    2014-10-01

    In this paper, we describe a new digital receiver developed for a 1.3-GHz range imaging atmospheric radar. The digital receiver comprises a general-purpose software-defined radio receiver referred to as the Universal Software Radio Peripheral 2 (USRP2) and a commercial personal computer (PC). The receiver is designed to collect received signals at an intermediate frequency (IF) of 130 MHz with a sample rate of 10 MS s-1. The USRP2 digitizes IF received signals, produces IQ time series, and then transfers the IQ time series to the PC through Gigabit Ethernet. The PC receives the IQ time series, performs range sampling, carries out filtering in the range direction, decodes the phase-modulated received signals, integrates the received signals in time, and finally saves the processed data to the hard disk drive (HDD). Because only sequential data transfer from the USRP2 to the PC is available, the range sampling is triggered by transmitted pulses leaked to the receiver. For range imaging, the digital receiver performs real-time signal processing for each of the time series collected at different frequencies. Further, the receiver is able to decode phase-modulated oversampled signals. Because the program code for real-time signal processing is written in a popular programming language (C++) and widely used libraries, the signal processing is easy to implement, reconfigure, and reuse. From radar experiments using a 1-μs subpulse width and 1-MHz frequency span (i.e., 2-MHz frequency bandwidth), we demonstrate that range imaging in combination with oversampling, which was implemented for the first time by the digital receiver, is able to resolve the fine-scale structure of turbulence with a vertical scale as small as 100 m or finer.

  6. Radiant energy receiver having improved coolant flow control means

    DOEpatents

    Hinterberger, H.

    1980-10-29

    An improved coolant flow control for use in radiant energy receivers of the type having parallel flow paths is disclosed. A coolant performs as a temperature dependent valve means, increasing flow in the warmer flow paths of the receiver, and impeding flow in the cooler paths of the receiver. The coolant has a negative temperature coefficient of viscosity which is high enough such that only an insignificant flow through the receiver is experienced at the minimum operating temperature of the receiver, and such that a maximum flow is experienced at the maximum operating temperature of the receiver. The valving is accomplished by changes in viscosity of the coolant in response to the coolant being heated and cooled. No remotely operated valves, comparators or the like are needed.

  7. Sensitivity loss of digital optical receivers caused by intersymbol interference

    NASA Astrophysics Data System (ADS)

    Chen, F. S.; Chen, Y. S.

    1980-12-01

    This paper describes studies of the dependence of optical receiver sensitivity on the launched-pulse width, pulse rise and fall times, and fiber dispersion for nonequalizing receivers. For pulse widths less than a time slot T in the return-to-zero (RZ) format and for small fiber dispersion sigma sub f, it is shown that the receiver sensitivity depends principally on the number of photons received per time slot and only weakly on the pulse width and rise and fall times of the launched pulses. For pulse widths equal to or greater than a time slot and/or with increased fiber dispersion (sigma sub f/T greater than 0.2), the receiver sensitivity degrades rapidly. Thus the sensitivity of receivers improves by use of reduced-width launched pulses in RZ format, particularly if the fiber dispersion is large.

  8. Interference-Detection Module in a Digital Radar Receiver

    NASA Technical Reports Server (NTRS)

    Fischman, Mark; Berkun, Andrew; Chu, Anhua; Freedman, Adam; Jourdan, Michael; McWatters, Dalia; Paller, Mimi

    2009-01-01

    A digital receiver in a 1.26-GHz spaceborne radar scatterometer now undergoing development includes a module for detecting radio-frequency interference (RFI) that could contaminate scientific data intended to be acquired by the scatterometer. The role of the RFI-detection module is to identify time intervals during which the received signal is likely to be contaminated by RFI and thereby to enable exclusion, from further scientific data processing, of signal data acquired during those intervals. The underlying concepts of detection of RFI and rejection of RFI-contaminated signal data are also potentially applicable in advanced terrestrial radio receivers, including software-defined radio receivers in general, receivers in cellular telephones and other wireless consumer electronic devices, and receivers in automotive collision-avoidance radar systems.

  9. 16. SECOND FLOOR RCA COMMUNICATION RECEIVING STATION FORMERLY THE POINTTOPOINT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. SECOND FLOOR RCA COMMUNICATION RECEIVING STATION FORMERLY THE POINT-TO-POINT RECEIVERS WERE LOCATED HERE. (SOUTHEAST ARCHIVAL PHOTOS AND RCA LOGO ON FLOOR AS A REFERENCE). DURING THE LAST PHASE OF THE RCA ERA AND DURING GENERAL ELECTRIC-AMERITRON OWNERSHIP THIS ROOM HOUSED SATELLITE OPERATING EQUIPMENT. WHEN BOUGHT BY MCI EQUIPMENT (HI TECH) WAS REMOVED. AREA IS NOW USED FOR NATIONAL PARK SERVICE LAW ENFORCEMENT PERSONNEL. - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  10. An RZ DPSK receiver design with significantly improved dispersion tolerance.

    PubMed

    Govan, Donald S; Doran, Nick

    2007-12-10

    We show an improved DPSK receiver design which can increase useful dispersion tolerance by up to a factor of two. The increased dispersion tolerance is achieved through optimization of the optical filter at the receiver and the delay of the Mach-Zehnder interferometer. In this paper we fully explain the concept, quantify the gain and provide an explanation for the operation of the receiver.

  11. 7. DETAIL, WINDOWS AND SAFETY LADDER AT RECEIVING DEPARTMENT, NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. DETAIL, WINDOWS AND SAFETY LADDER AT RECEIVING DEPARTMENT, NORTH SIDE, NEAR WEST END. - United Engineering Company Shipyard, Inspection & Repair Shops, 2900 Main Street, Alameda, Alameda County, CA

  12. Microwave and millimetre-wave receivers with integral antenna

    NASA Astrophysics Data System (ADS)

    Alder, C. J.; Brewitt-Taylor, C. R.; Dixon, M.; Hodges, R. D.; Irving, L. D.

    1991-06-01

    A family of microwave receivers is described which consists of antennas integrated with a balanced mixer and IF amplifier on a common substrate. Each receiver is small enough to enable two-dimensional arrays to be fabricated monolithically within a single semiconductor chip. The antenna pattern of each receiver is suitable for feeding via a dielectric immersion lens, thereby creating a high-gain array of beams in the farfield. Such receivers have been built to operate at 10 and 35 GHz, and show conversion loss similar to more conventional designs.

  13. Reduction of convective losses in solar cavity receivers

    NASA Astrophysics Data System (ADS)

    Hughes, Graham; Pye, John; Kaufer, Martin; Abbasi-Shavazi, Ehsan; Zhang, Jack; McIntosh, Adam; Lindley, Tim

    2016-05-01

    Two design innovations are reported that can help improve the thermal performance of a solar cavity receiver. These innovations utilise the natural variation of wall temperature inside the cavity and active management of airflow in the vicinity of the receiver. The results of computational fluid dynamics modelling and laboratory-scale experiments suggest that the convective loss from a receiver can be reduced substantially by either mechanism. A further benefit is that both radiative and overall thermal losses from the cavity may be reduced. Further work to assess the performance of such receiver designs under operational conditions is discussed.

  14. Frequency Estimator Performance for a Software-Based Beacon Receiver

    NASA Technical Reports Server (NTRS)

    Zemba, Michael J.; Morse, Jacquelynne Rose; Nessel, James A.; Miranda, Felix

    2014-01-01

    As propagation terminals have evolved, their design has trended more toward a software-based approach that facilitates convenient adjustment and customization of the receiver algorithms. One potential improvement is the implementation of a frequency estimation algorithm, through which the primary frequency component of the received signal can be estimated with a much greater resolution than with a simple peak search of the FFT spectrum. To select an estimator for usage in a QV-band beacon receiver, analysis of six frequency estimators was conducted to characterize their effectiveness as they relate to beacon receiver design.

  15. Frequency Estimator Performance for a Software-Based Beacon Receiver

    NASA Technical Reports Server (NTRS)

    Zemba, Michael J.; Morse, Jacquelynne R.; Nessel, James A.

    2014-01-01

    As propagation terminals have evolved, their design has trended more toward a software-based approach that facilitates convenient adjustment and customization of the receiver algorithms. One potential improvement is the implementation of a frequency estimation algorithm, through which the primary frequency component of the received signal can be estimated with a much greater resolution than with a simple peak search of the FFT spectrum. To select an estimator for usage in a Q/V-band beacon receiver, analysis of six frequency estimators was conducted to characterize their effectiveness as they relate to beacon receiver design.

  16. 7 CFR 1956.71 - Settling uncollectible recapture receivables.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF... Multi-Family Housing § 1956.71 Settling uncollectible recapture receivables. The settlement...

  17. Support and maneuvering apparatus for solar energy receivers

    DOEpatents

    Murphy, L.M.

    1988-07-28

    A support and maneuvering apparatus is disclosed for a solar energy receiving device adapted for receiving and concentrating solar energy and having a central axis extending through the center thereof. The apparatus includes a frame for mounting the perimeter of said solar energy receiving device. A support member extends along the central axis of the receiving device and has a base end passing through the center of the receiving device and an outer distal end adapted for carrying a solar energy receiving and conversion mechanism. A variable tension mechanism interconnects the support member with the frame to provide stiffening for the support member and the frame and to assist in the alignment of the frame to optimize the optical efficiency of the solar energy receiving device. A rotatable base is provided, and connecting members extend from the base for pivotable attachment to the frame at spaced positions therealong. Finally, an elevation assembly is connected to the receiving device for selectively pivoting the receiving about an axis defined between the attachment positions of the connecting members on the frame. 4 figs.

  18. Support and maneuvering apparatus for solar energy receivers

    DOEpatents

    Murphy, Lawrence M.

    1989-01-01

    A support and maneuvering apparatus is disclosed for a solar energy receiving device adpated for receiving and concentrating solar energy and having a central axis extending through the center thereof. The apparatus includes a frame for mounting the perimeter of said solar energy receiving device. A support member extends along the central axis of the receiving device and has a base end passing through the center of the receiving device and an outer distal end adapted for carrying a solar energy receiving and conversion mechanism. A variable tension mechanism interconnects the support member with the frame to provide stiffening for the support member and the frame and to assist in the alignment of the frame to optimize the optical efficiency of the solar energy receiving device. A rotatable base is provided, and connecting members extend from the base for pivotable attachment to the frame at spaced positions therealong. Finally, an elevation assembly is connected to the receiving device for selectively pivoting the receiving device about an axis defined between the attachment positions of the connecting members on the frame.

  19. Flexible All-Digital Receiver for Bandwidth Efficient Modulations

    NASA Technical Reports Server (NTRS)

    Gray, Andrew; Srinivasan, Meera; Simon, Marvin; Yan, Tsun-Yee

    2000-01-01

    An all-digital high data rate parallel receiver architecture developed jointly by Goddard Space Flight Center and the Jet Propulsion Laboratory is presented. This receiver utilizes only a small number of high speed components along with a majority of lower speed components operating in a parallel frequency domain structure implementable in CMOS, and can currently process up to 600 Mbps with standard QPSK modulation. Performance results for this receiver for bandwidth efficient QPSK modulation schemes such as square-root raised cosine pulse shaped QPSK and Feher's patented QPSK are presented, demonstrating the flexibility of the receiver architecture.

  20. Signal-processing theory for the TurboRogue receiver

    NASA Technical Reports Server (NTRS)

    Thomas, J. B.

    1995-01-01

    Signal-processing theory for the TurboRogue receiver is presented. The signal form is traced from its formation at the GPS satellite, to the receiver antenna, and then through the various stages of the receiver, including extraction of phase and delay. The analysis treats the effects of ionosphere, troposphere, signal quantization, receiver components, and system noise, covering processing in both the 'code mode' when the P code is not encrypted and in the 'P-codeless mode' when the P code is encrypted. As a possible future improvement to the current analog front end, an example of a highly digital front end is analyzed.

  1. 25 CFR 175.22 - Requirements for receiving electrical service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... POWER UTILITIES Utility Service Administration § 175.22 Requirements for receiving electrical service... service, shall enter into a written service agreement or special contract for electrical power services. ... 25 Indians 1 2011-04-01 2011-04-01 false Requirements for receiving electrical service....

  2. 25 CFR 175.22 - Requirements for receiving electrical service.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... POWER UTILITIES Utility Service Administration § 175.22 Requirements for receiving electrical service... service, shall enter into a written service agreement or special contract for electrical power services. ... 25 Indians 1 2012-04-01 2011-04-01 true Requirements for receiving electrical service....

  3. 25 CFR 175.22 - Requirements for receiving electrical service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... POWER UTILITIES Utility Service Administration § 175.22 Requirements for receiving electrical service... service, shall enter into a written service agreement or special contract for electrical power services. ... 25 Indians 1 2010-04-01 2010-04-01 false Requirements for receiving electrical service....

  4. 25 CFR 175.22 - Requirements for receiving electrical service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... POWER UTILITIES Utility Service Administration § 175.22 Requirements for receiving electrical service... service, shall enter into a written service agreement or special contract for electrical power services. ... 25 Indians 1 2013-04-01 2013-04-01 false Requirements for receiving electrical service....

  5. 25 CFR 175.22 - Requirements for receiving electrical service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... POWER UTILITIES Utility Service Administration § 175.22 Requirements for receiving electrical service... service, shall enter into a written service agreement or special contract for electrical power services. ... 25 Indians 1 2014-04-01 2014-04-01 false Requirements for receiving electrical service....

  6. 7 CFR 400.209 - Electronic transmission and receiving system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Electronic transmission and receiving system. 400.209... Contract-Standards for Approval § 400.209 Electronic transmission and receiving system. Any Contractor...; (b) Maintain an electronic system which must be tested and approved by the Corporation; (c)...

  7. 30 CFR 57.13011 - Air receiver tanks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... exceeding the maximum allowable working pressure in a receiver tank by not more than 10 percent. Air... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Air receiver tanks. 57.13011 Section 57.13011... SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Compressed Air...

  8. 78 FR 68135 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www... related to handling hazmat (including but not limited to acceptance, rejection, handling, storage... individuals used by Atlas and received hazmat training from a foreign air carrier issued...

  9. Receiving versus being denied an abortion and subsequent tobacco use.

    PubMed

    Roberts, Sarah C M; Foster, Diana Greene

    2015-03-01

    The negative health consequences of tobacco use are well documented. Some research finds women receiving abortions are at increased risk of subsequent tobacco use. This literature has methodological problems, most importantly, inappropriate comparison groups. This study uses data from the Turnaway Study, a longitudinal study of women who all sought, but did not all receive, abortions at 30 facilities across the United States. Participants included women presenting just before an abortion facility's gestational age limit who received abortions (Near Limit Abortion Group, n = 452), just after the gestational limit who were denied abortions (Turnaways, n = 231), and who received first trimester abortions (First Trimester Abortion Group, n = 273). This study examined the association between receiving versus being denied an abortion and subsequent tobacco use over 2-years. Trajectories of tobacco use over 2 years were compared using multivariate mixed effects regression. Women receiving abortion maintained their level of tobacco use over 2 years. Women denied abortion initially had lower levels of tobacco use than women receiving abortion, but increased their tobacco use from 1 week through 12-18 months post-abortion seeking and then decreased their use by 2 years post-abortion seeking. Baseline parity modified these associations. Receiving an abortion was not associated with an increase in tobacco use over time. Overall, women who carry unwanted pregnancies to term appear to demonstrate similar cessation and resumption patterns to other pregnant women.

  10. Polarisation-insensitive optical heterodyne receiver for coherent FSK communications

    NASA Astrophysics Data System (ADS)

    Kreit, D.; Youngquist, R. C.

    1987-02-01

    An optical FSK heterodyne communications receiver is proposed using a polarization diversity technique which has a reduced level of complexity. The proposed receiver is constructed and tested at 100 kbit/s and shown to have a maximum fluctuation in sensitivity of 17 percent over conditions of originally complete polarization fading.

  11. Qualification test for the flexible receiver. Revision 2

    SciTech Connect

    Tedeschi, D.J.

    1994-12-12

    This document provides the test plan and procedures to certify and design verify the 42{double_prime} and 4{double_prime}-6{double_prime} Flexible Receiver as a safety class 3 system. The Flexible Receiver will be used by projects W-151 and W-320 for removing equipment from tanks C-106 and AZ-101.

  12. 10. VIEW EAST (93 DEGREES) OF RCA COMMUNICATION RECEIVING STATION. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW EAST (93 DEGREES) OF RCA COMMUNICATION RECEIVING STATION. WOOD FRAMING SUPPORTED STANDOFF INSULATORS AND ANTENNA WIRES COMING FROM THE FIELD INTO THE BUILDING. BOLT ON FOUNDATION POLES SUPPORTED SATELLITE ANTENNAS, METAL CAP AND POSTS AT LEFT PROTECTED CONDUIT SUPPLYING POWER TO SATELLITE ANTENNA MOTORS. - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  13. Combined software GPS/Galileo receiver and applications

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoli; Liu, Jingnan; Li, Tao; McLeod, Robert D.

    2005-11-01

    Modernized GPS and Galileo will be available to civil users at the end of this decade, thus there is a need for unified platform that can receive multi-frequency signal of GPS/Galileo to develop and test for growing variety of diverse applications. The unified platform for various applications will speed the design process and reduce its cost. Such a platform need an open architecture and design flexibility so that modifications and testing can be done conveniently and efficiently. The flexible, reconfigurable, combined and software based Global Navigation Satellite Systems (GNSS) receiver will allow development, test and measurement of a variety of receiver architectures. This paper proposes a structure of combined multi-frequency software GPS/Galileo receiver for future GNSS receiver, which can utilize the planned GPS and Galileo publicly available signals. The receiver consists of a hardware multi-frequency front end responsible for both capturing all planned civil satellite-based radio-navigation signals. A followed programmable processor performs signal correlation. The correlator output then goes on signal processing totally using software. The correlator can be implemented either completely in software or using Field Programmable Gate Array (FPGA) for real time processing. The software modules for signal processing are easily updated. Improvements in accuracy and integrity are also achieved by GPS/Galileo Receiver Autonomous Integrity Monitoring (RAIM). The combined software implementation of processing modules makes this system a truly versatile GNSS receiver suitable for various applications.

  14. Satellite Receiving Station Handbook for Rural School Districts.

    ERIC Educational Resources Information Center

    Adams, James C.; And Others

    This handbook gives the historical background of a 2-year project conducted in a rural Wisconsin school district, outlining the planning and actual construction of a high school satellite receiving station. It is written to aid rural school districts in purchasing, installing, and using a satellite receiving station to improve the quality of…

  15. 14 CFR 221.162 - Receiver shall file adoption notices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A...

  16. 14 CFR 221.162 - Receiver shall file adoption notices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A...

  17. 14 CFR 221.162 - Receiver shall file adoption notices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A...

  18. 14 CFR 221.162 - Receiver shall file adoption notices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A...

  19. 14 CFR 221.162 - Receiver shall file adoption notices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Receiver shall file adoption notices. 221... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.162 Receiver shall file adoption notices. A...

  20. 7 CFR 400.209 - Electronic transmission and receiving system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Electronic transmission and receiving system. 400.209... Contract-Standards for Approval § 400.209 Electronic transmission and receiving system. Any Contractor... Corporation approval of the electronic system as a condition to the electronic transmission and reception...

  1. 7 CFR 400.209 - Electronic transmission and receiving system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Electronic transmission and receiving system. 400.209... Contract-Standards for Approval § 400.209 Electronic transmission and receiving system. Any Contractor... Corporation approval of the electronic system as a condition to the electronic transmission and reception...

  2. 27 CFR 24.315 - Materials received and used record.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... grapes (or other fruit) received on wine premises are used in producing juice to be stored for future use or for removal, the record will show the quantity used and juice produced. (b) Concentrated fruit juice. When concentrated fruit juice or must is produced or received, the record will show the...

  3. 27 CFR 24.315 - Materials received and used record.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... grapes (or other fruit) received on wine premises are used in producing juice to be stored for future use or for removal, the record will show the quantity used and juice produced. (b) Concentrated fruit juice. When concentrated fruit juice or must is produced or received, the record will show the...

  4. Design of a hybrid receiver for the OLYMPUS spacecraft beacons

    NASA Technical Reports Server (NTRS)

    Sweeney, D. G.; Mckeeman, J. C.

    1990-01-01

    The theory and design of a hybrid analogue/digital receiver which acquires and monitors the OLYMPUS satellite beacons is presented. The analogue portion of this receiver uses a frequency locked loop for signal tracking. A digital sampling detector operating at IF is used to obtain the I and Q outputs.

  5. Numerical modeling of dish-Stirling reflux solar receivers

    SciTech Connect

    Hogan, R.E.

    1990-01-01

    Using reflux solar receivers to collect solar energy for dish-Stirling electric power generation systems is currently being investigated by several organizations, including Sandia National Laboratories, Albuquerque, New Mexico. In support of this program, Sandia has developed two numerical models describing the energy transfer within and thermal performance of pool-boiler and heat-pipe receivers. Both models are applicable to axisymmetric geometries and they both consider the radiative and convective energy transfer within the receiver cavity, the conductive and convective energy transfer within the receiver cavity, the conductive and convective energy transfer from the receiver housing, and the energy transfer to the receiver working fluid. In these models, the radiative transfer within the receiver is analyzed using a two-band (solar and infrared) net-radiation formulation for enclosure radiation. Empirical convective correlations describe the convective heat transfer from the cavity to the surroundings. The primary difference between the models is the level of detail in modeling the heat conduction through the receiver walls. The more detailed model uses a two-dimensional finite control volume method, whereas the simpler model uses a one-dimensional thermal resistance approach. 20 refs., 7 figs., 2 tabs.

  6. 17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. VIEW OF RCA COMMUNICATIONS RECEIVING STATION DOWN AVENUE OF MONTEREY CYPRESS. THE TREES WERE CAREFULLY CULTIVATED TO FORM A LANDSCAPED APPROACH TO THE STATION. NOTE ANTENNA FIELD AT LEFT VIEW 312 DEGREES NORTHWEST. - Marconi Radio Sites, Receiving, Point Reyes Station, Marin County, CA

  7. 48 CFR 1446.670 - Inspection, receiving and acceptance reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... acceptance reports. 1446.670 Section 1446.670 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT QUALITY ASSURANCE Material Inspection and Receiving Reports 1446.670 Inspection, receiving and acceptance reports. (a) Except for simplified acquisitions (See FAR 46.404)...

  8. Low cost airborne microwave landing system receiver, task 3

    NASA Technical Reports Server (NTRS)

    Hager, J. B.; Vancleave, J. R.

    1979-01-01

    Work performed on the low cost airborne Microwave Landing System (MLS) receiver is summarized. A detailed description of the prototype low cost MLS receiver is presented. This detail includes block diagrams, schematics, board assembly drawings, photographs of subassemblies, mechanical construction, parts lists, and microprocessor software. Test procedures are described and results are presented.

  9. 42 CFR 435.120 - Individuals receiving SSI.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CFR 416.260 through 416.269 contain requirements governing determinations of eligibility under this... 42 Public Health 4 2010-10-01 2010-10-01 false Individuals receiving SSI. 435.120 Section 435.120..., Blind, and Disabled § 435.120 Individuals receiving SSI. Except as allowed under § 435.121, the...

  10. Treatment Services Received in the CASAWORKS for Families Program

    ERIC Educational Resources Information Center

    Mckay, James R.; Gutman, Marjorie; Mclellan, A. Thomas; Lynch, Kevin G.; Ketterlinus, Robert

    2003-01-01

    This article presents information on treatment services received by women participating in an initial multistate evaluation of CASAWORKS families. Results indicated most women received services to address medical, employment, basic needs, alcohol and drug, family, and psychiatric problems during the first six months of the program. The clients…

  11. A digital-receiver for the MurchisonWidefield Array

    NASA Astrophysics Data System (ADS)

    Prabu, Thiagaraj; Srivani, K. S.; Roshi, D. Anish; Kamini, P. A.; Madhavi, S.; Emrich, David; Crosse, Brian; Williams, Andrew J.; Waterson, Mark; Deshpande, Avinash A.; Shankar, N. Udaya; Subrahmanyan, Ravi; Briggs, Frank H.; Goeke, Robert F.; Tingay, Steven J.; Johnston-Hollitt, Melanie; R, Gopalakrishna M.; Morgan, Edward H.; Pathikulangara, Joseph; Bunton, John D.; Hampson, Grant; Williams, Christopher; Ord, Stephen M.; Wayth, Randall B.; Kumar, Deepak; Morales, Miguel F.; deSouza, Ludi; Kratzenberg, Eric; Pallot, D.; McWhirter, Russell; Hazelton, Bryna J.; Arcus, Wayne; Barnes, David G.; Bernardi, Gianni; Booler, T.; Bowman, Judd D.; Cappallo, Roger J.; Corey, Brian E.; Greenhill, Lincoln J.; Herne, David; Hewitt, Jacqueline N.; Kaplan, David L.; Kasper, Justin C.; Kincaid, Barton B.; Koenig, Ronald; Lonsdale, Colin J.; Lynch, Mervyn J.; Mitchell, Daniel A.; Oberoi, Divya; Remillard, Ronald A.; Rogers, Alan E.; Salah, Joseph E.; Sault, Robert J.; Stevens, Jamie B.; Tremblay, S.; Webster, Rachel L.; Whitney, Alan R.; Wyithe, Stuart B.

    2015-03-01

    An FPGA-based digital-receiver has been developed for a low-frequency imaging radio interferometer, the Murchison Widefield Array (MWA). The MWA, located at the Murchison Radio-astronomy Observatory (MRO) in Western Australia, consists of 128 dual-polarized aperture-array elements (tiles) operating between 80 and 300 MHz, with a total processed bandwidth of 30.72 MHz for each polarization. Radio-frequency signals from the tiles are amplified and band limited using analog signal conditioning units; sampled and channelized by digital-receivers. The signals from eight tiles are processed by a single digital-receiver, thus requiring 16 digital-receivers for the MWA. The main function of the digital-receivers is to digitize the broad-band signals from each tile, channelize them to form the sky-band, and transport it through optical fibers to a centrally located correlator for further processing. The digital-receiver firmware also implements functions to measure the signal power, perform power equalization across the band, detect interference-like events, and invoke diagnostic modes. The digital-receiver is controlled by high-level programs running on a single-board-computer. This paper presents the digital-receiver design, implementation, current status, and plans for future enhancements.

  12. 20 CFR 663.220 - Who may receive intensive services?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) ADULT AND DISLOCATED WORKER ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Intensive Services § 663.220 Who may receive intensive services? There are two categories of adults and dislocated workers who may receive intensive services: (a) Adults and dislocated workers who are unemployed,...

  13. Proceedings of the First Semiannual Distributed Receiver Program Review

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Point focus and line focus distributed receiver solar thermal technology for the production of electric power and of industrial process heat is addressed. Concentrator, receiver, and power conversion development are covered along with hardware tests and evaluation. Mass production costing, parabolic dish applications, and trough and bowl systems are included.

  14. Low-distortion receiver for bilevel, baseband PCM waveforms

    NASA Technical Reports Server (NTRS)

    Proch, G. E.

    1974-01-01

    Digital receiver improves discrimination between information signals and noise and provides order to magnitude reduction in systematic distortion. Receiver combines advantages of band-limiting prefilter and high-amplitude thresholds to provide asynchronous discrimination between information signals and spurious signals.

  15. 12 CFR 614.4700 - Financing foreign trade receivables.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... reputation and financial strength of the exporter. (e) The banks may establish foreign trade receivable... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Financing foreign trade receivables. 614.4700 Section 614.4700 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES...

  16. 12 CFR 614.4700 - Financing foreign trade receivables.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... reputation and financial strength of the exporter. (e) The banks may establish foreign trade receivable... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Financing foreign trade receivables. 614.4700 Section 614.4700 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES...

  17. 12 CFR 614.4700 - Financing foreign trade receivables.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... reputation and financial strength of the exporter. (e) The banks may establish foreign trade receivable... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Financing foreign trade receivables. 614.4700 Section 614.4700 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES...

  18. 12 CFR 614.4700 - Financing foreign trade receivables.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... reputation and financial strength of the exporter. (e) The banks may establish foreign trade receivable... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Financing foreign trade receivables. 614.4700 Section 614.4700 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES...

  19. 12 CFR 614.4700 - Financing foreign trade receivables.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... reputation and financial strength of the exporter. (e) The banks may establish foreign trade receivable... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Financing foreign trade receivables. 614.4700 Section 614.4700 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES...

  20. 7 CFR 981.472 - Report of almonds received.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Report of almonds received. 981.472 Section 981.472... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.472 Report of almonds received. (a) Each handler shall report to...

  1. 7 CFR 981.472 - Report of almonds received.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Report of almonds received. 981.472 Section 981.472... AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.472 Report of almonds received. (a) Each handler shall report to...

  2. 7 CFR 981.472 - Report of almonds received.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Report of almonds received. 981.472 Section 981.472... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.472 Report of almonds received. (a) Each handler shall report to...

  3. 7 CFR 981.472 - Report of almonds received.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Report of almonds received. 981.472 Section 981.472... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.472 Report of almonds received. (a) Each handler shall report to...

  4. 7 CFR 981.472 - Report of almonds received.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Report of almonds received. 981.472 Section 981.472... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.472 Report of almonds received. (a) Each handler shall report to...

  5. 21 CFR 870.2920 - Telephone electrocardiograph transmitter and receiver.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Telephone electrocardiograph transmitter and... § 870.2920 Telephone electrocardiograph transmitter and receiver. (a) Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it...

  6. 21 CFR 870.2920 - Telephone electrocardiograph transmitter and receiver.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Telephone electrocardiograph transmitter and... § 870.2920 Telephone electrocardiograph transmitter and receiver. (a) Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it...

  7. 21 CFR 870.2920 - Telephone electrocardiograph transmitter and receiver.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Telephone electrocardiograph transmitter and... § 870.2920 Telephone electrocardiograph transmitter and receiver. (a) Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it...

  8. 21 CFR 870.2920 - Telephone electrocardiograph transmitter and receiver.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Telephone electrocardiograph transmitter and... § 870.2920 Telephone electrocardiograph transmitter and receiver. (a) Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it...

  9. 78 FR 21702 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ... Federal holidays. Privacy: We will post all comments we receive, without change, to http://www.regulations... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www... sought would allow Flight Safety International, Inc., to re-qualify an Embraer Flight Simulation...

  10. Optical superheterodyne receiver uses laser for local oscillator

    NASA Technical Reports Server (NTRS)

    Lucy, R. F.

    1966-01-01

    Optical superheterodyne receiver uses a laser coupled to a frequency translator to supply both the incident signal and local oscillator signal and thus permit reception of amplitude modulated video bandwidth signals through the atmosphere. This receiver is useful in scientific propagation experiments, tracking experiments, and communication experiments.

  11. 37 CFR 1.412 - The United States Receiving Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false The United States Receiving Office. 1.412 Section 1.412 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Information § 1.412 The United States Receiving Office. (a) The United States Patent and Trademark Office is...

  12. 48 CFR 1446.671 - Inspection, receiving and acceptance certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Inspection, receiving and acceptance certification. 1446.671 Section 1446.671 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT QUALITY ASSURANCE Material Inspection and Receiving Reports §...

  13. 48 CFR 1846.672-7 - Receiving instructions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Receiving instructions. 1846.672-7 Section 1846.672-7 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Material Inspection and Receiving Reports...

  14. 20 CFR 663.220 - Who may receive intensive services?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) ADULT AND DISLOCATED WORKER ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Intensive Services § 663.220 Who may receive intensive services? There are two categories of adults and dislocated workers who may receive intensive services: (a) Adults and dislocated workers who are unemployed,...

  15. 43 CFR 418.7 - Who may receive irrigation deliveries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Conditions of Water Delivery § 418.7 Who may receive irrigation deliveries. Project irrigation water... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Who may receive irrigation deliveries. 418... individual water right holder indicating the number of eligible acres irrigated and the amount of...

  16. 43 CFR 418.7 - Who may receive irrigation deliveries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Conditions of Water Delivery § 418.7 Who may receive irrigation deliveries. Project irrigation water... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Who may receive irrigation deliveries. 418... individual water right holder indicating the number of eligible acres irrigated and the amount of...

  17. 43 CFR 418.7 - Who may receive irrigation deliveries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Conditions of Water Delivery § 418.7 Who may receive irrigation deliveries. Project irrigation water... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Who may receive irrigation deliveries. 418... individual water right holder indicating the number of eligible acres irrigated and the amount of...

  18. An algorithm for the automatic synchronization of Omega receivers

    NASA Technical Reports Server (NTRS)

    Stonestreet, W. M.; Marzetta, T. L.

    1977-01-01

    The Omega navigation system and the requirement for receiver synchronization are discussed. A description of the synchronization algorithm is provided. The numerical simulation and its associated assumptions were examined and results of the simulation are presented. The suggested form of the synchronization algorithm and the suggested receiver design values were surveyed. A Fortran of the synchronization algorithm used in the simulation was also included.

  19. 21 CFR 870.2920 - Telephone electrocardiograph transmitter and receiver.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Telephone electrocardiograph transmitter and... § 870.2920 Telephone electrocardiograph transmitter and receiver. (a) Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it...

  20. 30 CFR 56.13011 - Air receiver tanks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... tanks also shall be equipped with indicating pressure gauges which accurately measure the pressure... § 56.13011 Air receiver tanks. Air receiver tanks shall be equipped with one or more automatic pressure-relief valves. The total relieving capacity of the relief valves shall prevent pressure from...