Pozdniakov, Sergey; Tsang, Chin-Fu
2004-01-02
In this paper, we consider an approach for estimating the effective hydraulic conductivity of a 3D medium with a binary distribution of local hydraulic conductivities. The medium heterogeneity is represented by a combination of matrix medium conductivity with spatially distributed sets of inclusions. Estimation of effective conductivity is based on a self-consistent approach introduced by Shvidler (1985). The tensor of effective hydraulic conductivity is calculated numerically by using a simple system of equations for the main diagonal elements. Verification of the method is done by comparison with theoretical results for special cases and numerical results of Desbarats (1987) and our own numerical modeling. The method was applied to estimating the effective hydraulic conductivity of a 2D and 3D fractured porous medium. The medium heterogeneity is represented by a combination of matrix conductivity and a spatially distributed set of highly conductive fractures. The tensor of effective hydraulic conductivity is calculated for parallel- and random-oriented sets of fractures. The obtained effective conductivity values coincide with Romm's (1966) and Snow's (1969) theories for infinite fracture length. These values are also physically acceptable for the sparsely-fractured-medium case with low fracture spatial density and finite fracture length. Verification of the effective hydraulic conductivity obtained for a fractured porous medium is done by comparison with our own numerical modeling for a 3D case and with Malkovsky and Pek's (1995) results for a 2D case.
A Heterogeneous Medium Analytical Benchmark
Ganapol, B.D.
1999-09-27
A benchmark, called benchmark BLUE, has been developed for one-group neutral particle (neutron or photon) transport in a one-dimensional sub-critical heterogeneous plane parallel medium with surface illumination. General anisotropic scattering is accommodated through the Green's Function Method (GFM). Numerical Fourier transform inversion is used to generate the required Green's functions which are kernels to coupled integral equations that give the exiting angular fluxes. The interior scalar flux is then obtained through quadrature. A compound iterative procedure for quadrature order and slab surface source convergence provides highly accurate benchmark qualities (4- to 5- places of accuracy) results.
Fluorescence lifetime measurements in heterogeneous scattering medium
NASA Astrophysics Data System (ADS)
Nishimura, Goro; Awasthi, Kamlesh; Furukawa, Daisuke
2016-07-01
Fluorescence lifetime in heterogeneous multiple light scattering systems is analyzed by an algorithm without solving the diffusion or radiative transfer equations. The algorithm assumes that the optical properties of medium are constant in the excitation and emission wavelength regions. If the assumption is correct and the fluorophore is a single species, the fluorescence lifetime can be determined by a set of measurements of temporal point-spread function of the excitation light and fluorescence at two different concentrations of the fluorophore. This method is not dependent on the heterogeneity of the optical properties of the medium as well as the geometry of the excitation-detection on an arbitrary shape of the sample. The algorithm was validated by an indocyanine green fluorescence in phantom measurements and demonstrated by an in vivo measurement.
On fluid flow in a heterogeneous medium under nonisothermal conditions
D.W., Vasco
2010-11-01
An asymptotic technique, valid in the presence of smoothly-varying heterogeneity, provides explicit expressions for the velocity of a propagating pressure and temperature disturbance. The governing equations contain nonlinear terms due to the presence of temperature-dependent coefficients and due to the advection of fluids with differing temperatures. Two cases give well-defined expressions in terms of the parameters of the porous medium: the uncoupled propagation of a pressure disturbance and the propagation of a fully coupled temperature and pressure disturbance. The velocity of the coupled disturbance or front, depends upon the medium parameters and upon the change in temperature and pressure across the front. For uncoupled flow, the semi-analytic expression for the front velocity reduces to that associated with a linear diffusion equation. A comparison of the asymptotic travel time estimates with calculations from a numerical simulator indicates reasonably good agreement for both uncoupled and coupled disturbances.
Modeling flow in a pressure-sensitive, heterogeneous medium
Vasco, Donald W.; Minkoff, Susan E.
2009-06-01
Using an asymptotic methodology, including an expansion in inverse powers of {radical}{omega}, where {omega} is the frequency, we derive a solution for flow in a medium with pressure dependent properties. The solution is valid for a heterogeneous medium with smoothly varying properties. That is, the scale length of the heterogeneity must be significantly larger then the scale length over which the pressure increases from it initial value to its peak value. The resulting asymptotic expression is similar in form to the solution for pressure in a medium in which the flow properties are not functions of pressure. Both the expression for pseudo-phase, which is related to the 'travel time' of the transient pressure disturbance, and the expression for pressure amplitude contain modifications due to the pressure dependence of the medium. We apply the method to synthetic and observed pressure variations in a deforming medium. In the synthetic test we model one-dimensional propagation in a pressure-dependent medium. Comparisons with both an analytic self-similar solution and the results of a numerical simulation indicate general agreement. Furthermore, we are able to match pressure variations observed during a pulse test at the Coaraze Laboratory site in France.
Vigorous convection in a layered, heterogeneous porous medium
NASA Astrophysics Data System (ADS)
Hewitt, D.; Neufeld, J. A.; Lister, J. R.
2014-12-01
Convective flow in a porous medium plays an important role in numerous geophysical and industrial processes, and has recently been investigated in the context of geological CO2 sequestration. Previous studies of vigorous porous convection at high Rayleigh number Ra have focused on homogeneous porous media, whereas natural porous media are often highly heterogeneous. In particular, many geological porous formations are interspersed with thin, roughly horizontal, low-permeability layers. In order to gain understanding of the interaction of low-permeability layering with convective flow, and to develop simple parameterized models of the underlying physical processes, we have performed a numerical study of high-Ra convection in a two-dimensional porous medium that contains a thin, horizontal, low-permeability interior layer. The medium is heated at the lower boundary and cooled at the upper, which sets up statistically steady convective flow throughout the domain. This archetypal system is readily applicable to compositional convection, owing to an assumption of thermal equilibrium between solid and liquid phase in the medium. We show that, in the limit that both the dimensionless thickness h and permeability Π of the low-permeability layer are small, the flow is described solely by the impedance of the layer Ω= h/Π and by Ra. As Ω → 0 (i.e. h → 0), the system reduces to a homogeneous medium. We observe two notable features as Ω is increased: the dominant horizontal lengthscale of the flow increases; and, surprisingly, the heat flux through the cell, as measured by the Nusselt number Nu, can increase. For larger values of Ω, Nu always decreases. We explore the dependence of the flow on Ra, and develop simple theoretical models to describe some of the observed features of the relationship Nu(Ω). The theoretical models have implications for the simulation of convective dissolution of CO2 at reservoir scales, as heterogeneities can be much smaller than the grid
NASA Technical Reports Server (NTRS)
Zhu, P. Y.; Fung, A. K.
1986-01-01
The effective medium approximation (EMA) formalism developed for scalar wave calculations in solid state physics is generalized to electromagnetic wave scattering in a dense random medium. Results are applied to compute the effective propagation constant in a dense medium involving discrete spherical scatterers. When compared with a common quasicrystalline approximation (QCA), it is found that EMA accounts for backward scattering and the effect of correlation among three scatterers which are not available in QCA. It is also found that there is not much difference in the calculated normalized phase velocity between the use of these two approximations. However, there is a significant difference in the computed effective loss tangent in a nonabsorptive random medium. The computed effective loss tangent using EMA and measurements from a snow medium are compared, showing good agreement.
Calculation of antibody affinity in homogeneous and heterogeneous systems.
Chalquest, R R
1988-12-01
Antibody affinity is an important determinant of all antibody-antigen reactions. A new computer program, AFCRV, was developed to calculate binding constants with data from a radioimmunoassay on most microcomputers in the laboratory by using constant-ratio dilution curves. Evaluation of a homogeneous or heterogeneous antibody in the presence of a single antigen can be accomplished.
NASA Astrophysics Data System (ADS)
Rohan, Eduard; Naili, Salah; Nguyen, Vu-Hieu
2016-08-01
We study wave propagation in an elastic porous medium saturated with a compressible Newtonian fluid. The porous network is interconnected whereby the pores are characterized by two very different characteristic sizes. At the mesoscopic scale, the medium is described using the Biot model, characterized by a high contrast in the hydraulic permeability and anisotropic elasticity, whereas the contrast in the Biot coupling coefficient is only moderate. Fluid motion is governed by the Darcy flow model extended by inertia terms and by the mass conservation equation. The homogenization method based on the asymptotic analysis is used to obtain a macroscopic model. To respect the high contrast in the material properties, they are scaled by the small parameter, which is involved in the asymptotic analysis and characterized by the size of the heterogeneities. Using the estimates of wavelengths in the double-porosity networks, it is shown that the macroscopic descriptions depend on the contrast in the static permeability associated with pores and micropores and on the frequency. Moreover, the microflow in the double porosity is responsible for fading memory effects via the macroscopic poroviscoelastic constitutive law. xml:lang="fr"
Applicability of the effective-medium approximation to heterogeneous aerosol particles
NASA Astrophysics Data System (ADS)
Mishchenko, Michael I.; Dlugach, Janna M.; Liu, Li
2016-07-01
The effective-medium approximation (EMA) is based on the assumption that a heterogeneous particle can have a homogeneous counterpart possessing similar scattering and absorption properties. We analyze the numerical accuracy of the EMA by comparing superposition T-matrix computations for spherical aerosol particles filled with numerous randomly distributed small inclusions and Lorenz-Mie computations based on the Maxwell-Garnett mixing rule. We verify numerically that the EMA can indeed be realized for inclusion size parameters smaller than a threshold value. The threshold size parameter depends on the refractive-index contrast between the host and inclusion materials and quite often does not exceed several tenths, especially in calculations of the scattering matrix and the absorption cross section. As the inclusion size parameter approaches the threshold value, the scattering-matrix errors of the EMA start to grow with increasing the host size parameter and/or the number of inclusions. We confirm, in particular, the existence of the effective-medium regime in the important case of dust aerosols with hematite or air-bubble inclusions, but then the large refractive-index contrast necessitates inclusion size parameters of the order of a few tenths. Irrespective of the highly restricted conditions of applicability of the EMA, our results provide further evidence that the effective-medium regime must be a direct corollary of the macroscopic Maxwell equations under specific assumptions.
Heterogeneous reactivity effects in medium- and high-enriched uranium metal-water systems
Lichtenwalter, J.J.
1997-07-01
The effect of heterogeneity on reactivity of low-, medium-, and high-enriched, water-moderated uranium metal systems has been examined for various hydrogen-to-fissile (H/X) ratios using the CSAS1X sequence in SCALE and MCNP. For the calculations, an infinite array of close-packed unit cells was modeled which consisted of centered uranium metal spheres surrounded by water. The enrichments used correspond to the average enrichments of fragmented fuel plates in three proposed waste shipments from Oak Ridge National Laboratory. The analysis performed to obtain peak reactivity for each enrichment as a function of particle size and H/X ratio led to the development of the topic discussed in this paper.
Speckle decorrelation study of phase heterogeneous liquid medium
NASA Astrophysics Data System (ADS)
Pobiedina, Valentyna; Yakunov, Andrey
2016-04-01
In the paper de-correlation method was applied to study the dynamics of the laser-speckle pattern caused with the ground glass and layer of transparent liquid. According to the percolation model H-bonded liquids are characterized with nano-sized structural heterogeneities that cause the phase ones for the light wave. The temporary changing phase heterogeneities modulate the speckle field produced with the ground glass. The modifying of the speckle pattern causes the slow decaying of the central peak amplitude of the cross-correlation between the first images and each subsequent one. Proposed method likely could be a foundation of new methods for contactless exploring structural dynamics of liquid systems.
Calculations of a wideband metamaterial absorber using equivalent medium theory
NASA Astrophysics Data System (ADS)
Huang, Xiaojun; Yang, Helin; Wang, Danqi; Yu, Shengqing; Lou, Yanchao; Guo, Ling
2016-08-01
Metamaterial absorbers (MMAs) have drawn increasing attention in many areas due to the fact that they can achieve electromagnetic (EM) waves with unity absorptivity. We demonstrate the design, simulation, experiment and calculation of a wideband MMA based on a loaded double-square-loop (DSL) array of chip resisters. For a normal incidence EM wave, the simulated results show that the absorption of the full width at half maximum is about 9.1 GHz, and the relative bandwidth is 87.1%. Experimental results are in agreement with the simulations. More importantly, equivalent medium theory (EMT) is utilized to calculate the absorptions of the DSL MMA, and the calculated absorptions based on EMT agree with the simulated and measured results. The method based on EMT provides a new way to analysis the mechanism of MMAs.
Wave propagation in elastic medium with heterogeneous quadratic nonlinearity
Tang Guangxin; Jacobs, Laurence J.; Qu Jianmin
2011-06-23
This paper studies the one-dimensional wave propagation in an elastic medium with spatially non-uniform quadratic nonlinearity. Two problems are solved analytically. One is for a time-harmonic wave propagating in a half-space where the displacement is prescribed on the surface of the half-space. It is found that spatial non-uniformity of the material nonlinearity causes backscattering of the second order harmonic, which when combined with the forward propagating waves generates a standing wave in steady-state wave motion. The second problem solved is the reflection from and transmission through a layer of finite thickness embedded in an otherwise linearly elastic medium of infinite extent, where it is assumed that the layer has a spatially non-uniform quadratic nonlinearity. The results show that the transmission coefficient for the second order harmonic is proportional to the spatial average of the nonlinearity across the thickness of the layer, independent of the spatial distribution of the nonlinearity. On the other hand, the coefficient of reflection is proportional to a weighted average of the nonlinearity across the layer thickness. The weight function in this weighted average is related to the propagating phase, thus making the coefficient of reflection dependent on the spatial distribution of the nonlinearity. Finally, the paper concludes with some discussions on how to use the reflected and transmitted second harmonic waves to evaluate the variance and autocorrelation length of nonlinear parameter {beta} when the nonlinearity distribution in the layer is a stochastic process.
Velocities of guided ultrasonic waves in heterogeneous medium
NASA Technical Reports Server (NTRS)
Touratier, M.
1984-01-01
Experimental and theoretical examinations were performed of the longitudinal velocity characteristics of waves in trilaminar and encapsulated waveguides. The study was confined to waveguides with core material that featured transverse wave velocities much worse than the longitudinal wave velocities. The velocities were obtained using a dispersion equation, with consideration given to both the core and encapsulant. Asymptotic velocities were also calculated for bending and twisting in trilaminar waveguides. Trials were run with bimetallic waveguides for comparison with the theoretical predictions. Good agreement was found between the predicted velocity of the propagation of the fundamental mode and the measured velocities. The method was calculated valid for modes above four, confirming that the data were contained in either the core or outer layer, and were unsensitive to the encapsulant.
Dense, Viscous Brine Behavior in Heterogeneous Porous Medium Systems
Wright, D. Johnson; Pedit, J.A.; Gasda, S.E.; Farthing, M.W.; Murphy, L.L.; Knight, S.R.; Brubaker, G.R.
2010-01-01
The behavior of dense, viscous calcium bromide brine solutions used to remediate systems contaminated with dense nonaqueous phase liquids (DNAPLs) is considered in laboratory and field porous medium systems. The density and viscosity of brine solutions are experimentally investigated and functional forms fit over a wide range of mass fractions. A density of 1.7 times, and a corresponding viscosity of 6.3 times, that of water is obtained at a calcium bromide mass fraction of 0.53. A three-dimensional laboratory cell is used to investigate the establishment, persistence, and rate of removal of a stratified dense brine layer in a controlled system. Results from a field-scale experiment performed at the Dover National Test Site are used to investigate the ability to establish and maintain a dense brine layer as a component of a DNAPL recovery strategy, and to recover the brine at sufficiently high mass fractions to support the economical reuse of the brine. The results of both laboratory and field experiments show that a dense brine layer can be established, maintained, and recovered to a significant extent. Regions of unstable density profiles are shown to develop and persist in the field-scale experiment, which we attribute to regions of low hydraulic conductivity. The saturated-unsaturated, variable-density ground-water flow simulation code SUTRA is modified to describe the system of interest, and used to compare simulations to experimental observations and to investigate certain unobserved aspects of these complex systems. The model results show that the standard model formulation is not appropriate for capturing the behavior of sharp density gradients observed during the dense brine experiments. PMID:20444520
Dense, viscous brine behavior in heterogeneous porous medium systems.
Wright, D Johnson; Pedit, J A; Gasda, S E; Farthing, M W; Murphy, L L; Knight, S R; Brubaker, G R; Miller, C T
2010-06-25
The behavior of dense, viscous calcium bromide brine solutions used to remediate systems contaminated with dense nonaqueous phase liquids (DNAPLs) is considered in laboratory and field porous medium systems. The density and viscosity of brine solutions are experimentally investigated and functional forms fit over a wide range of mass fractions. A density of 1.7 times, and a corresponding viscosity of 6.3 times, that of water is obtained at a calcium bromide mass fraction of 0.53. A three-dimensional laboratory cell is used to investigate the establishment, persistence, and rate of removal of a stratified dense brine layer in a controlled system. Results from a field-scale experiment performed at the Dover National Test Site are used to investigate the ability to establish and maintain a dense brine layer as a component of a DNAPL recovery strategy, and to recover the brine at sufficiently high mass fractions to support the economical reuse of the brine. The results of both laboratory and field experiments show that a dense brine layer can be established, maintained, and recovered to a significant extent. Regions of unstable density profiles are shown to develop and persist in the field-scale experiment, which we attribute to regions of low hydraulic conductivity. The saturated-unsaturated, variable-density groundwater flow simulation code SUTRA is modified to describe the system of interest, and used to compare simulations to experimental observations and to investigate certain unobserved aspects of these complex systems. The model results show that the standard model formulation is not appropriate for capturing the behavior of sharp density gradients observed during the dense brine experiments.
Tissue heterogeneity in IMRT dose calculation for lung cancer.
Pasciuti, Katia; Iaccarino, Giuseppe; Strigari, Lidia; Malatesta, Tiziana; Benassi, Marcello; Di Nallo, Anna Maria; Mirri, Alessandra; Pinzi, Valentina; Landoni, Valeria
2011-01-01
The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulated radiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the γ function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the lung and in the tumor area. These differences are not always in DVH of the lung, although the Wilcoxon test indicated significant differences in 2 of 4 patients. Disagreement in the lung region was also found when the Γ analysis was performed. The effect on TCP is less important than for NTCP because of the slope of the curve at the level of the dose of interest. The effect of dose calculation inaccuracy is patient-dependent and strongly related to beam geometry and to the localization of the tumor. When multiple intensity-modulated beams are used, the effect of the presence of the heterogeneity on dose distribution may not always be easily predictable. PMID:20970989
A Thin Film of an Ni NiO Heterogeneous System for an Optical Recording Medium
NASA Astrophysics Data System (ADS)
Iida, Atsuko; Nishikawa, Reiji
1994-07-01
The authors have found a write once read many (WORM) type new optical recording medium of an Ni NiO heterogeneous system thin film. The structure of the recording medium is a single layer Ni NiO heterogeneous thin film on a transparent resin substrate. Irradiation of a converged laser diode beam causes a volume expansion of the film to form a swell. Information reading is done by using its reduction in reflectivity. The recordable composition region of this film is considered to be the transitive region from the metal to the oxide. The volume expansion is assumed to be induced by the oxidation of the Ni NiO heterogeneous thin film and the height of the swell is estimated. This value agrees well with the measured top height of the swell.
Temporal behavior of a solute cloud in a fractal heterogeneous porous medium at different scales
NASA Astrophysics Data System (ADS)
Ross, Katharina; Attinger, Sabine
2010-05-01
Water pollution is still a very real problem and the need for efficient models for flow and solute transport in heterogeneous porous or fractured media is evident. In our study we focus on solute transport in heterogeneous fractured media. In heterogeneous fractured media the shape of the pores and fractures in the subsurface might be modeled as a fractal network or a heterogeneous structure with infinite correlation length. To derive explicit results for larger scale or effective transport parameters in such structures is the aim of this work. To describe flow and transport we investigate the temporal behavior of transport coefficients of solute movement through a spatially heterogeneous medium. It is necessary to distinguish between two fundamentally different quantities characterizing the solute dispersion: The effective dispersion coefficient Deff(t) represents the physical (observable) dispersion in one given realization of the medium. It is conceptually different from the mathematically simpler ensemble dispersion coefficient Dens(t) which characterizes the (abstract) dispersion with respect to the set of all possible realizations of the medium. In the framework of a stochastic approach DENTZ ET AL. (2000 I[2] & II[3]) derive explicit expressions for the temporal behavior of the center-of-mass velocity and the dispersion of the concentration distribution, using a second order perturbation expansion. In their model the authors assume a finite correlation length of the heterogeneities and use a GAUSSIAN correlation function. In a first step, we model the fractured medium as a heterogeneous porous medium with infinite correlation length and neglect single fractures. ZHAN & WHEATCRAFT (1996[4]) analyze the macrodispersivity tensor in fractal porous media using a non-integer exponent which consists of the HURST coefficient and the fractal dimension D. To avoid this non-integer exponent for numerical reasons we extend the study of DENTZ ET AL. (2000 I[2] & II[3
TH-A-19A-01: An Open Source Software for Proton Treatment Planning in Heterogeneous Medium
Desplanques, M; Baroni, G; Wang, K; Phillips, J; Gueorguiev, G; Sharp, G
2014-06-15
Purpose: Due to its success in Radiation Oncology during the last decade, interest in proton therapy is on the rise. Unfortunately, despite the global enthusiasm in the field, there is presently no free, multiplatform and customizable Treatment Planning System (TPS) providing proton dose distributions in heterogenous medium. This restricts substantially the progress of clinical research for groups without access to a commercial Proton TPS. The latest implementation of our pencil beam dose calculation algorithm for proton beams within the 3D Slicer open-source environment fulfills all the conditions described above. Methods: The core dose calculation algorithm is based on the Hong algorithm (1), which was upgraded with the Kanematsu theory describing the evolution of the lateral scattering of proton beamlets in heterogeneous medium. This algorithm deals with both mono-energetic beams and Spread Out Bragg Peak (SOBP). In order to be user-friendly, we provide a graphical user interface implemented with the Qt libraries, and visualization with the 3D Slicer medical image analysis software. Two different pencil beam algorithms were developed, and the clinical proton beam line at our facility was modeled. Results: The dose distributions provided by our algorithms were compared to dose distributions coming from both commercialized XiO TPS and literature (dose measurements, GEANT4 and MCNPx) and turned out to be in a good agreement, with maximum dose discrepancies of 5% in homogeneous phantoms and 10% in heterogeneous phantoms. The algorithm of SOBP creation from an optimized weigthing of mono-energetic beams results in flat SOBP. Conclusion: We hope that our efforts in implementing this new, open-source proton TPS will help the research groups to have a free access to a useful, reliable proton dose calculation software.(1) L. Hong et al., A pencil beam algorithm for proton dose calculations, Phys. Med. Biol. 41 (1996) 1305–1330. This project is paid for by NCI
Dagrau, Franck; Rénier, Mathieu; Marchiano, Régis; Coulouvrat, François
2011-07-01
Numerical simulation of nonlinear acoustics and shock waves in a weakly heterogeneous and lossless medium is considered. The wave equation is formulated so as to separate homogeneous diffraction, heterogeneous effects, and nonlinearities. A numerical method called heterogeneous one-way approximation for resolution of diffraction (HOWARD) is developed, that solves the homogeneous part of the equation in the spectral domain (both in time and space) through a one-way approximation neglecting backscattering. A second-order parabolic approximation is performed but only on the small, heterogeneous part. So the resulting equation is more precise than the usual standard or wide-angle parabolic approximation. It has the same dispersion equation as the exact wave equation for all forward propagating waves, including evanescent waves. Finally, nonlinear terms are treated through an analytical, shock-fitting method. Several validation tests are performed through comparisons with analytical solutions in the linear case and outputs of the standard or wide-angle parabolic approximation in the nonlinear case. Numerical convergence tests and physical analysis are finally performed in the fully heterogeneous and nonlinear case of shock wave focusing through an acoustical lens.
Han Tao; Followill, David; Repchak, Roman; Molineu, Andrea; Howell, Rebecca; Salehpour, Mohammad; Mikell, Justin; Mourtada, Firas
2013-05-15
Purpose: The novel deterministic radiation transport algorithm, Acuros XB (AXB), has shown great potential for accurate heterogeneous dose calculation. However, the clinical impact between AXB and other currently used algorithms still needs to be elucidated for translation between these algorithms. The purpose of this study was to investigate the impact of AXB for heterogeneous dose calculation in lung cancer for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Methods: The thorax phantom from the Radiological Physics Center (RPC) was used for this study. IMRT and VMAT plans were created for the phantom in the Eclipse 11.0 treatment planning system. Each plan was delivered to the phantom three times using a Varian Clinac iX linear accelerator to ensure reproducibility. Thermoluminescent dosimeters (TLDs) and Gafchromic EBT2 film were placed inside the phantom to measure delivered doses. The measurements were compared with dose calculations from AXB 11.0.21 and the anisotropic analytical algorithm (AAA) 11.0.21. Two dose reporting modes of AXB, dose-to-medium in medium (D{sub m,m}) and dose-to-water in medium (D{sub w,m}), were studied. Point doses, dose profiles, and gamma analysis were used to quantify the agreement between measurements and calculations from both AXB and AAA. The computation times for AAA and AXB were also evaluated. Results: For the RPC lung phantom, AAA and AXB dose predictions were found in good agreement to TLD and film measurements for both IMRT and VMAT plans. TLD dose predictions were within 0.4%-4.4% to AXB doses (both D{sub m,m} and D{sub w,m}); and within 2.5%-6.4% to AAA doses, respectively. For the film comparisons, the gamma indexes ({+-}3%/3 mm criteria) were 94%, 97%, and 98% for AAA, AXB{sub Dm,m}, and AXB{sub Dw,m}, respectively. The differences between AXB and AAA in dose-volume histogram mean doses were within 2% in the planning target volume, lung, heart, and within 5% in the spinal cord
Han, Tao; Followill, David; Mikell, Justin; Repchak, Roman; Molineu, Andrea; Howell, Rebecca; Salehpour, Mohammad; Mourtada, Firas
2013-01-01
Purpose: The novel deterministic radiation transport algorithm, Acuros XB (AXB), has shown great potential for accurate heterogeneous dose calculation. However, the clinical impact between AXB and other currently used algorithms still needs to be elucidated for translation between these algorithms. The purpose of this study was to investigate the impact of AXB for heterogeneous dose calculation in lung cancer for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Methods: The thorax phantom from the Radiological Physics Center (RPC) was used for this study. IMRT and VMAT plans were created for the phantom in the Eclipse 11.0 treatment planning system. Each plan was delivered to the phantom three times using a Varian Clinac iX linear accelerator to ensure reproducibility. Thermoluminescent dosimeters (TLDs) and Gafchromic EBT2 film were placed inside the phantom to measure delivered doses. The measurements were compared with dose calculations from AXB 11.0.21 and the anisotropic analytical algorithm (AAA) 11.0.21. Two dose reporting modes of AXB, dose-to-medium in medium (Dm,m) and dose-to-water in medium (Dw,m), were studied. Point doses, dose profiles, and gamma analysis were used to quantify the agreement between measurements and calculations from both AXB and AAA. The computation times for AAA and AXB were also evaluated. Results: For the RPC lung phantom, AAA and AXB dose predictions were found in good agreement to TLD and film measurements for both IMRT and VMAT plans. TLD dose predictions were within 0.4%–4.4% to AXB doses (both Dm,m and Dw,m); and within 2.5%–6.4% to AAA doses, respectively. For the film comparisons, the gamma indexes (±3%/3 mm criteria) were 94%, 97%, and 98% for AAA, AXB_Dm,m, and AXB_Dw,m, respectively. The differences between AXB and AAA in dose–volume histogram mean doses were within 2% in the planning target volume, lung, heart, and within 5% in the spinal cord. However, differences up to 8
Application of Effective Medium Theory to the Three-Dimensional Heterogeneity of Mantle Anisotropy
NASA Astrophysics Data System (ADS)
Song, X.; Jordan, T. H.
2015-12-01
A self-consistent theory for the effective elastic parameters of stochastic media with small-scale 3D heterogeneities has been developed using a 2nd-order Born approximation to the scattered wavefield (T. H. Jordan, GJI, in press). Here we apply the theory to assess how small-scale variations in the local anisotropy of the upper mantle affect seismic wave propagation. We formulate a anisotropic model in which the local elastic properties are specified by a constant stiffness tensor with hexagonal symmetry of arbitrary orientation. This orientation is guided by a Gaussian random vector field with transversely isotropic (TI) statistics. If the outer scale of the statistical variability is small compared to a wavelength, then the effective seismic velocities are TI and depend on two parameters, a horizontal-to-vertical orientation ratio ξ and a horizontal-to-vertical aspect ratio, η. If ξ = 1, the symmetry axis is isotropically distributed; if ξ < 1, it is vertical biased (bipolar distribution), and if ξ > 1, it is horizontally biased (girdle distribution). If η = 1, the heterogeneity is geometrically isotropic; as η à∞, the medium becomes a horizontal stochastic laminate; as η à0, the medium becomes a vertical stochastic bundle. Using stiffness tensors constrained by laboratory measurements of mantle xenoliths, we explore the dependence of the effective P and S velocities on ξ and η. The effective velocities are strongly controlled by the orientation ratio ξ; e.g., if the hexagonal symmetry axis of the local anisotropy is the fast direction of propagation, then vPH > vPV and vSH > vSV for ξ > 1. A more surprising result is the 2nd-order insensitivity of the velocities to the heterogeneity aspect ratio η. Consequently, the geometrical anisotropy of upper-mantle heterogeneity significantly enhances seismic-wave anisotropy only through local variations in the Voigt-averaged velocities, which depend primarily on rock composition and not deformation
Benchmarking analytical calculations of proton doses in heterogeneous matter
Ciangaru, George; Polf, Jerimy C.; Bues, Martin; Smith, Alfred R.
2005-12-15
A proton dose computational algorithm, performing an analytical superposition of infinitely narrow proton beamlets (ASPB) is introduced. The algorithm uses the standard pencil beam technique of laterally distributing the central axis broad beam doses according to the Moliere scattering theory extended to slablike varying density media. The purpose of this study was to determine the accuracy of our computational tool by comparing it with experimental and Monte Carlo (MC) simulation data as benchmarks. In the tests, parallel wide beams of protons were scattered in water phantoms containing embedded air and bone materials with simple geometrical forms and spatial dimensions of a few centimeters. For homogeneous water and bone phantoms, the proton doses we calculated with the ASPB algorithm were found very comparable to experimental and MC data. For layered bone slab inhomogeneity in water, the comparison between our analytical calculation and the MC simulation showed reasonable agreement, even when the inhomogeneity was placed at the Bragg peak depth. There also was reasonable agreement for the parallelepiped bone block inhomogeneity placed at various depths, except for cases in which the bone was located in the region of the Bragg peak, when discrepancies were as large as more than 10%. When the inhomogeneity was in the form of abutting air-bone slabs, discrepancies of as much as 8% occurred in the lateral dose profiles on the air cavity side of the phantom. Additionally, the analytical depth-dose calculations disagreed with the MC calculations within 3% of the Bragg peak dose, at the entry and midway depths in the phantom. The distal depth-dose 20%-80% fall-off widths and ranges calculated with our algorithm and the MC simulation were generally within 0.1 cm of agreement. The analytical lateral-dose profile calculations showed smaller (by less than 0.1 cm) 20%-80% penumbra widths and shorter fall-off tails than did those calculated by the MC simulations. Overall
Benchmarking analytical calculations of proton doses in heterogeneous matter.
Ciangaru, George; Polf, Jerimy C; Bues, Martin; Smith, Alfred R
2005-12-01
A proton dose computational algorithm, performing an analytical superposition of infinitely narrow proton beamlets (ASPB) is introduced. The algorithm uses the standard pencil beam technique of laterally distributing the central axis broad beam doses according to the Moliere scattering theory extended to slablike varying density media. The purpose of this study was to determine the accuracy of our computational tool by comparing it with experimental and Monte Carlo (MC) simulation data as benchmarks. In the tests, parallel wide beams of protons were scattered in water phantoms containing embedded air and bone materials with simple geometrical forms and spatial dimensions of a few centimeters. For homogeneous water and bone phantoms, the proton doses we calculated with the ASPB algorithm were found very comparable to experimental and MC data. For layered bone slab inhomogeneity in water, the comparison between our analytical calculation and the MC simulation showed reasonable agreement, even when the inhomogeneity was placed at the Bragg peak depth. There also was reasonable agreement for the parallelepiped bone block inhomogeneity placed at various depths, except for cases in which the bone was located in the region of the Bragg peak, when discrepancies were as large as more than 10%. When the inhomogeneity was in the form of abutting air-bone slabs, discrepancies of as much as 8% occurred in the lateral dose profiles on the air cavity side of the phantom. Additionally, the analytical depth-dose calculations disagreed with the MC calculations within 3% of the Bragg peak dose, at the entry and midway depths in the phantom. The distal depth-dose 20%-80% fall-off widths and ranges calculated with our algorithm and the MC simulation were generally within 0.1 cm of agreement. The analytical lateral-dose profile calculations showed smaller (by less than 0.1 cm) 20%-80% penumbra widths and shorter fall-off tails than did those calculated by the MC simulations. Overall
Panchangam, Sri Chandana; Lin, Angela Yu-Chen; Shaik, Khaja Lateef; Lin, Cheng-Fang
2009-09-01
Decomposition of perfluorocarboxylic acids (PFCAs) is of prime importance since they are recognized as persistent organic pollutants and are widespread in the environment. PFCAs with longer carbon chain length are particularly of interest because of their noted recalcitrance, toxicity, and bioaccumulation. Here in this study, we demonstrate efficient decomposition of three important PFCAs such as perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) by heterogeneous photocatalysis with TiO(2) as a photocatalyst in acidic aqueous solutions. The PFCAs were decomposed into shorter carbon chain length PFCAs and fluoride ions. Photoholes of excited TiO(2) generated upon UV-irradiation are found to be the oxidation sites for PFCAs. Therefore, creation and sustenance of these photoholes in the acidic aqueous medium has enhanced the decomposition of PFCAs. Heterogeneous photocatalytic treatment achieved more than 99% decomposition and 38% complete mineralization of PFOA in 7h. The decomposition of other PFCAs was as high as 99% with a defluorination efficiency of 38% for PFDA and 54% for PFNA. The presence of perchloric acid was found to enhance the decomposition by facilitating the ionization of PFCAs. The oxygen present in the medium served both as an oxidant and an electron acceptor. The mechanistic details of PFCA decomposition and their corresponding mineralization are elaborated.
Oostrom, Martinus; Freedman, Vicky L.; Wietsma, Thomas W.; Dane, Jacob H.; Truex, Michael J.
2012-11-01
Soil desiccation (drying), involving water evaporation induced by dry gas injection, is a potentially robust vadose zone remediation process to limit contaminant transport through the vadose zone. A series of four intermediate-scale flow cell experiments was conducted in homogeneous and simple layered heterogeneous porous medium systems to investigate the effects of heterogeneity on desiccation of unsaturated porous media. The permeability ratios of porous medium layers ranged from about five to almost two orders of magnitude. The insulated flow cell was equipped with twenty humidity and temperature sensors and a dual-energy gamma system was used to determine water saturations at various times. The multiphase code STOMP was used to simulate the desiccation process. Results show that injected dry gas flowed predominantly in the higher permeability layer and delayed water removal from the lower permeability material. For the configurations tested, water vapor diffusion from the lower to the higher permeability zone was considerable over the duration of the experiments, resulting in much larger relative humidity values of the outgoing air than based on permeability ratios alone. Acceptable numerical matches with the experimental data were obtained when an extension of the saturation-capillary pressure relation below the residual water saturation was used. The agreements between numerical and experimental results suggest that the correct physics are implemented in the simulator and that the thermal and hydraulic properties of the porous media, flow cell wall and insulation materials were properly represented.
A Method for Correcting IMRT Optimizer Heterogeneity Dose Calculations
Zacarias, Albert S.; Brown, Mellonie F. Mills, Michael D.
2010-04-01
Radiation therapy treatment planning for volumes close to the patient's surface, in lung tissue and in the head and neck region, can be challenging for the planning system optimizer because of the complexity of the treatment and protected volumes, as well as striking heterogeneity corrections. Because it is often the goal of the planner to produce an isodose plan with uniform dose throughout the planning target volume (PTV), there is a need for improved planning optimization procedures for PTVs located in these anatomical regions. To illustrate such an improved procedure, we present a treatment planning case of a patient with a lung lesion located in the posterior right lung. The intensity-modulated radiation therapy (IMRT) plan generated using standard optimization procedures produced substantial dose nonuniformity across the tumor caused by the effect of lung tissue surrounding the tumor. We demonstrate a novel iterative method of dose correction performed on the initial IMRT plan to produce a more uniform dose distribution within the PTV. This optimization method corrected for the dose missing on the periphery of the PTV and reduced the maximum dose on the PTV to 106% from 120% on the representative IMRT plan.
Adaptations in Electronic Structure Calculations in Heterogeneous Environments
Talamudupula, Sai
2011-01-01
Modern quantum chemistry deals with electronic structure calculations of unprecedented complexity and accuracy. They demand full power of high-performance computing and must be in tune with the given architecture for superior e ciency. To make such applications resourceaware, it is desirable to enable their static and dynamic adaptations using some external software (middleware), which may monitor both system availability and application needs, rather than mix science with system-related calls inside the application. The present work investigates scienti c application interlinking with middleware based on the example of the computational chemistry package GAMESS and middleware NICAN. The existing synchronous model is limited by the possible delays due to the middleware processing time under the sustainable runtime system conditions. Proposed asynchronous and hybrid models aim at overcoming this limitation. When linked with NICAN, the fragment molecular orbital (FMO) method is capable of adapting statically and dynamically its fragment scheduling policy based on the computing platform conditions. Signi cant execution time and throughput gains have been obtained due to such static adaptations when the compute nodes have very di erent core counts. Dynamic adaptations are based on the main memory availability at run time. NICAN prompts FMO to postpone scheduling certain fragments, if there is not enough memory for their immediate execution. Hence, FMO may be able to complete the calculations whereas without such adaptations it aborts.
Influence investigation of a void region on modeling light propagation in a heterogeneous medium.
Yang, Defu; Chen, Xueli; Ren, Shenghan; Qu, Xiaochao; Tian, Jie; Liang, Jimin
2013-01-20
A void region exists in some biological tissues, and previous studies have shown that inaccurate images would be obtained if it were not processed. A hybrid radiosity-diffusion method (HRDM) that couples the radiosity theory and the diffusion equation has been proposed to deal with the void problem and has been well demonstrated in two-dimensional and three-dimensional (3D) simple models. However, the extent of the impact of the void region on the accuracy of modeling light propagation has not been investigated. In this paper, we first implemented and verified the HRDM in 3D models, including both the regular geometries and a digital mouse model, and then investigated the influences of the void region on modeling light propagation in a heterogeneous medium. Our investigation results show that the influence of the region can be neglected when the size of the void is less than a certain range, and other cases must be taken into account. PMID:23338186
Influence investigation of a void region on modeling light propagation in a heterogeneous medium.
Yang, Defu; Chen, Xueli; Ren, Shenghan; Qu, Xiaochao; Tian, Jie; Liang, Jimin
2013-01-20
A void region exists in some biological tissues, and previous studies have shown that inaccurate images would be obtained if it were not processed. A hybrid radiosity-diffusion method (HRDM) that couples the radiosity theory and the diffusion equation has been proposed to deal with the void problem and has been well demonstrated in two-dimensional and three-dimensional (3D) simple models. However, the extent of the impact of the void region on the accuracy of modeling light propagation has not been investigated. In this paper, we first implemented and verified the HRDM in 3D models, including both the regular geometries and a digital mouse model, and then investigated the influences of the void region on modeling light propagation in a heterogeneous medium. Our investigation results show that the influence of the region can be neglected when the size of the void is less than a certain range, and other cases must be taken into account.
Mashouf, Shahram; Lechtman, Eli; Beaulieu, Luc; Verhaegen, Frank; Keller, Brian M; Ravi, Ananth; Pignol, Jean-Philippe
2013-09-21
The American Association of Physicists in Medicine Task Group No. 43 (AAPM TG-43) formalism is the standard for seeds brachytherapy dose calculation. But for breast seed implants, Monte Carlo simulations reveal large errors due to tissue heterogeneity. Since TG-43 includes several factors to account for source geometry, anisotropy and strength, we propose an additional correction factor, called the inhomogeneity correction factor (ICF), accounting for tissue heterogeneity for Pd-103 brachytherapy. This correction factor is calculated as a function of the media linear attenuation coefficient and mass energy absorption coefficient, and it is independent of the source internal structure. Ultimately the dose in heterogeneous media can be calculated as a product of dose in water as calculated by TG-43 protocol times the ICF. To validate the ICF methodology, dose absorbed in spherical phantoms with large tissue heterogeneities was compared using the TG-43 formalism corrected for heterogeneity versus Monte Carlo simulations. The agreement between Monte Carlo simulations and the ICF method remained within 5% in soft tissues up to several centimeters from a Pd-103 source. Compared to Monte Carlo, the ICF methods can easily be integrated into a clinical treatment planning system and it does not require the detailed internal structure of the source or the photon phase-space.
NASA Astrophysics Data System (ADS)
Le Bihan, Nicolas; Margerin, Ludovic
2009-07-01
In this paper, we present a nonparametric method to estimate the heterogeneity of a random medium from the angular distribution of intensity of waves transmitted through a slab of random material. Our approach is based on the modeling of forward multiple scattering using compound Poisson processes on compact Lie groups. The estimation technique is validated through numerical simulations based on radiative transfer theory.
Le Bihan, Nicolas; Margerin, Ludovic
2009-07-01
In this paper, we present a nonparametric method to estimate the heterogeneity of a random medium from the angular distribution of intensity of waves transmitted through a slab of random material. Our approach is based on the modeling of forward multiple scattering using compound Poisson processes on compact Lie groups. The estimation technique is validated through numerical simulations based on radiative transfer theory.
NASA Astrophysics Data System (ADS)
Oostrom, M.; Dane, J. H.; Wietsma, T. W.
2004-12-01
An intermediate-scale flow cell experiment was conducted to study the behavior of a multicomponent DNAPL at structural interfaces and subsequent remediation using two different forms of the soil vapor extraction (SVE) technique. The flow cell (100-cm long, 5-cm wide, and 80 cm high), was packed under saturated conditions with sloped layers of Hanford silt and coarse sand, embedded in a matrix of a medium-grained laboratory sand. After packing, the water table was lowered to 2 cm above the bottom of the flow cell to establish variably saturated conditions. A finite amount of a volatile multicomponent DNAPL, mimicking the organic liquid disposed at the Hanford Site, was then injected from a small source zone. The infiltration and redistribution processes were visually recorded. In addition, a dual-energy gamma radiation system was used to determine DNAPL and water saturation at more than 1000 locations. Results indicate that lateral spreading of the DNAPL is greatly enhanced by the heterogeneities. The silt layers, by virtue of their substantial non-wetting fluid entry pressures and high water saturations, completely diverted the DNAPL laterally. The relatively dry coarse-sand layers forced some of the DNAPL to move laterally but also allowed some infiltration.
Quasi-heterogeneous efficient 3-D discrete ordinates CANDU calculations using Attila
Preeti, T.; Rulko, R.
2012-07-01
In this paper, 3-D quasi-heterogeneous large scale parallel Attila calculations of a generic CANDU test problem consisting of 42 complete fuel channels and a perpendicular to fuel reactivity device are presented. The solution method is that of discrete ordinates SN and the computational model is quasi-heterogeneous, i.e. fuel bundle is partially homogenized into five homogeneous rings consistently with the DRAGON code model used by the industry for the incremental cross-section generation. In calculations, the HELIOS-generated 45 macroscopic cross-sections library was used. This approach to CANDU calculations has the following advantages: 1) it allows detailed bundle (and eventually channel) power calculations for each fuel ring in a bundle, 2) it allows the exact reactivity device representation for its precise reactivity worth calculation, and 3) it eliminates the need for incremental cross-sections. Our results are compared to the reference Monte Carlo MCNP solution. In addition, the Attila SN method performance in CANDU calculations characterized by significant up scattering is discussed. (authors)
Trajectory-based modeling of fluid transport in a medium with smoothly varying heterogeneity
NASA Astrophysics Data System (ADS)
Vasco, D. W.; Pride, Steven R.; Commer, Michael
2016-04-01
Using an asymptotic methodology, valid in the presence of smoothly varying heterogeneity and prescribed boundaries, we derive a trajectory-based solution for tracer transport. The analysis produces a Hamilton-Jacobi partial differential equation for the phase of the propagating tracer front. The trajectories follow from the characteristic equations that are equivalent to the Hamilton-Jacobi equation. The paths are determined by the fluid velocity field, the total porosity, and the dispersion tensor. Due to their dependence upon the local hydrodynamic dispersion, they differ from conventional streamlines. This difference is borne out in numerical calculations for both uniform and dipole flow fields. In an application to the computational X-ray imaging of a saline tracer test, we illustrate that the trajectories may serve as the basis for a form of tracer tomography. In particular, we use the onset time of a change in attenuation for each volume element of the X-ray image as a measure of the arrival time of the saline tracer. The arrival times are used to image the spatial variation of the effective hydraulic conductivity within the laboratory sample.
NASA Astrophysics Data System (ADS)
Song, Y. M.; Li, J. W.; Cai, F. H.
2016-01-01
In near-infrared spectroscopy, fiber optic probe is usually applied to incident light into the bio-sample and detect the spatial and temporal resolved optical signal re-emitted from the turbid medium. In this point-source-point-detector measurement system, seed Perturbation Monte Carlo (Pmc) method is an effective model to perform the forward simulation. In our study, the integration of parallel computing with graphics processing units(GPU) into the existing seed Pmc method substantially accelerate the speed of the original simulation. The GPU based seed Pmc provide an excellent solution for the application of fiber optic probe in both homogeneous a heterogeneous turbid medium.
In-to-Out Body Antenna-Independent Path Loss Model for Multilayered Tissues and Heterogeneous Medium
Kurup, Divya; Vermeeren, Günter; Tanghe, Emmeric; Joseph, Wout; Martens, Luc
2015-01-01
In this paper, we investigate multilayered lossy and heterogeneous media for wireless body area networks (WBAN) to develop a simple, fast and efficient analytical in-to-out body path loss (PL) model at 2.45 GHz and, thus, avoid time-consuming simulations. The PL model is an antenna-independent model and is validated with simulations in layered medium, as well as in a 3D human model using electromagnetic solvers. PMID:25551483
Westerly, David C.; Mo Xiaohu; DeLuca, Paul M. Jr.; Tome, Wolfgang A.; Mackie, Thomas R.
2013-06-15
Purpose: Pencil beam algorithms are commonly used for proton therapy dose calculations. Szymanowski and Oelfke ['Two-dimensional pencil beam scaling: An improved proton dose algorithm for heterogeneous media,' Phys. Med. Biol. 47, 3313-3330 (2002)] developed a two-dimensional (2D) scaling algorithm which accurately models the radial pencil beam width as a function of depth in heterogeneous slab geometries using a scaled expression for the radial kernel width in water as a function of depth and kinetic energy. However, an assumption made in the derivation of the technique limits its range of validity to cases where the input expression for the radial kernel width in water is derived from a local scattering power model. The goal of this work is to derive a generalized form of 2D pencil beam scaling that is independent of the scattering power model and appropriate for use with any expression for the radial kernel width in water as a function of depth. Methods: Using Fermi-Eyges transport theory, the authors derive an expression for the radial pencil beam width in heterogeneous slab geometries which is independent of the proton scattering power and related quantities. The authors then perform test calculations in homogeneous and heterogeneous slab phantoms using both the original 2D scaling model and the new model with expressions for the radial kernel width in water computed from both local and nonlocal scattering power models, as well as a nonlocal parameterization of Moliere scattering theory. In addition to kernel width calculations, dose calculations are also performed for a narrow Gaussian proton beam. Results: Pencil beam width calculations indicate that both 2D scaling formalisms perform well when the radial kernel width in water is derived from a local scattering power model. Computing the radial kernel width from a nonlocal scattering model results in the local 2D scaling formula under-predicting the pencil beam width by as much as 1.4 mm (21%) at the depth
Westerly, David C.; Mo, Xiaohu; Tomé, Wolfgang A.; Mackie, Thomas R.; DeLuca, Paul M.
2013-01-01
Purpose: Pencil beam algorithms are commonly used for proton therapy dose calculations. Szymanowski and Oelfke [“Two-dimensional pencil beam scaling: An improved proton dose algorithm for heterogeneous media,” Phys. Med. Biol. 47, 3313–3330 (2002)10.1088/0031-9155/47/18/304] developed a two-dimensional (2D) scaling algorithm which accurately models the radial pencil beam width as a function of depth in heterogeneous slab geometries using a scaled expression for the radial kernel width in water as a function of depth and kinetic energy. However, an assumption made in the derivation of the technique limits its range of validity to cases where the input expression for the radial kernel width in water is derived from a local scattering power model. The goal of this work is to derive a generalized form of 2D pencil beam scaling that is independent of the scattering power model and appropriate for use with any expression for the radial kernel width in water as a function of depth. Methods: Using Fermi-Eyges transport theory, the authors derive an expression for the radial pencil beam width in heterogeneous slab geometries which is independent of the proton scattering power and related quantities. The authors then perform test calculations in homogeneous and heterogeneous slab phantoms using both the original 2D scaling model and the new model with expressions for the radial kernel width in water computed from both local and nonlocal scattering power models, as well as a nonlocal parameterization of Molière scattering theory. In addition to kernel width calculations, dose calculations are also performed for a narrow Gaussian proton beam. Results: Pencil beam width calculations indicate that both 2D scaling formalisms perform well when the radial kernel width in water is derived from a local scattering power model. Computing the radial kernel width from a nonlocal scattering model results in the local 2D scaling formula under-predicting the pencil beam width by as
Accounting for strong localized heterogeneities and local transport effect in core calculations
Ruggieri, J.M.; Doriath, J.Y.; Finck, P.J.; Boyer, R.
1996-09-01
Two methods based on the variational nodal transport method have been developed to account for localized heterogeneities and local transport effects in full core calculations. A local mesh refinement technique relies on using the projected partial ingoing surface currents produced during coarse-mesh iterations as boundary conditions for fine-mesh calculations embedded within the coarse-mesh calculations. The outgoing fine-mesh partial currents are averaged to serve in the coarse-mesh iterations. Then, a mixed transport-diffusion method using two levels of angular approximations for the surface partial currents depending on the node considered has been implemented to account for local transport effects in full core diffusion calculations. These methods have been tested for a model of the Superphenix complementary shutdown rods.
A new pencil beam model for photon dose calculations in heterogeneous media.
Zhang, P; Simon, A; De Crevoisier, R; Haigron, P; Nassef, M H; Li, B; Shu, H
2014-11-01
The pencil beam method is commonly used for dose calculations in intensity-modulated radiation therapy (IMRT). In this study, we have proposed a novel pencil model for calculating photon dose distributions in heterogeneous media. To avoid any oblique kernel-related bias and reduce computation time, dose distributions were computed in a spherical coordinate system based on the pencil kernels of different distances from source to surface (DSS). We employed two different dose calculation methods: the superposition method and the fast Fourier transform convolution (FFTC) method. In order to render the superposition method more accurate, we scaled the depth-directed component by moving the position of the entry point and altering the DSS value for a given beamlet. The lateral components were thus directly corrected by the density scaling method along the spherical shell without taking the densities from the previous layers into account. Significant computation time could be saved by performing the FFTC calculations on each spherical shell, disregarding density changes in the lateral direction. The proposed methods were tested on several phantoms, including lung- and bone-type heterogeneities. We compared them with Monte Carlo (MC) simulation for several field sizes with 6 MV photon beams. Our results revealed mean absolute deviations <1% for the proposed superposition method. Compared to the AAA algorithm, this method improved dose calculation accuracy by at least 0.3% in heterogeneous phantoms. The FFTC method was approximately 40 times faster than the superposition method. However, compared with MC, mean absolute deviations were <3% for the FFTC method.
Calculating alpha Eigenvalues in a Continuous-Energy Infinite Medium with Monte Carlo
Betzler, Benjamin R.; Kiedrowski, Brian C.; Brown, Forrest B.; Martin, William R.
2012-09-04
The {alpha} eigenvalue has implications for time-dependent problems where the system is sub- or supercritical. We present methods and results from calculating the {alpha}-eigenvalue spectrum for a continuous-energy infinite medium with a simplified Monte Carlo transport code. We formulate the {alpha}-eigenvalue problem, detail the Monte Carlo code physics, and provide verification and results. We have a method for calculating the {alpha}-eigenvalue spectrum in a continuous-energy infinite-medium. The continuous-time Markov process described by the transition rate matrix provides a way of obtaining the {alpha}-eigenvalue spectrum and kinetic modes. These are useful for the approximation of the time dependence of the system.
Punegov, V. I. Sivkov, D. V.
2015-03-15
Two independent approaches to calculate the angular distribution of X-ray diffusion scattering from a crystalline medium with spheroidal quantum dots (QDs) have been proposed. The first method is based on the analytical solution involving the multipole expansion of elastic strain fields beyond QDs. The second approach is based on calculations of atomic displacements near QDs by the Green’s function method. An analysis of the diffuse scattering intensity distribution in the reciprocal space within these two approaches shows that both methods yield similar results for the chosen models of QD spatial distribution.
Scholl, M.A.
2000-01-01
Numerical simulations were used to examine the effects of heterogeneity in hydraulic conductivity (K) and intrinsic biodegradation rate on the accuracy of contaminant plume-scale biodegradation rates obtained from field data. The simulations were based on a steady-state BTEX contaminant plume-scale biodegradation under sulfate-reducing conditions, with the electron acceptor in excess. Biomass was either uniform or correlated with K to model spatially variable intrinsic biodegradation rates. A hydraulic conductivity data set from an alluvial aquifer was used to generate three sets of 10 realizations with different degrees of heterogeneity, and contaminant transport with biodegradation was simulated with BIOMOC. Biodegradation rates were calculated from the steady-state contaminant plumes using decreases in concentration with distance downgradient and a single flow velocity estimate, as is commonly done in site characterization to support the interpretation of natural attenuation. The observed rates were found to underestimate the actual rate specified in the heterogeneous model in all cases. The discrepancy between the observed rate and the 'true' rate depended on the ground water flow velocity estimate, and increased with increasing heterogeneity in the aquifer. For a lognormal K distribution with variance of 0.46, the estimate was no more than a factor of 1.4 slower than the true rate. For aquifer with 20% silt/clay lenses, the rate estimate was as much as nine times slower than the true rate. Homogeneous-permeability, uniform-degradation rate simulations were used to generate predictions of remediation time with the rates estimated from heterogeneous models. The homogeneous models were generally overestimated the extent of remediation or underestimated remediation time, due to delayed degradation of contaminants in the low-K areas. Results suggest that aquifer characterization for natural attenuation at contaminated sites should include assessment of the presence
Calculation of Physicochemical Properties for Short- and Medium-Chain Chlorinated Paraffins
NASA Astrophysics Data System (ADS)
Glüge, Juliane; Bogdal, Christian; Scheringer, Martin; Buser, Andreas M.; Hungerbühler, Konrad
2013-06-01
Short- and medium-chain chlorinated paraffins are potential PBT chemicals (persistent, bioaccumulative, toxic) and short-chain chlorinated paraffins are under review for inclusion in the UNEP Stockholm Convention on Persistent Organic Pollutants. Despite their high production volume of more than one million metric tonnes per year, only few data on their physicochemical properties are available. We calculated subcooled-liquid vapor pressure, subcooled-liquid solubility in water and octanol, Henry's law constant for water and octanol, as well as the octanol-water partition coefficient with the property calculation methods COSMOtherm, SPARC, and EPI Suite™, and compared the results to experimental data from the literature. For all properties, good or very good agreement between calculated and measured data was obtained for COSMOtherm; results from SPARC were in good agreement with the measured data except for subcooled-liquid water solubility, whereas EPI Suite™ showed the largest discrepancies for all properties. After critical evaluation of the three property calculation methods, a final set of recommended property data for short- and medium-chain chlorinated paraffins was derived. The calculated property data show interesting relationships with chlorine content and carbon chain length. Increasing chlorine content does not cause pronounced changes in water solubility and octanol-water partition coefficient (KOW) as long as it is below 55%. Increasing carbon chain length leads to strong increases in KOW and corresponding decreases in subcooled-liquid water solubility. The present data set can be used in further studies to assess the environmental fate and human exposure of this relevant compound class.
Linda M. Abriola; Avery H. Demond
2005-01-10
Dense nonaqueous phase liquids (DNAPLs) pose a significant threat to soil and groundwater at Department of Energy (DOE) sites. Evidence suggests that subsurface wettability variations are present at many of these sites as a result of spatical and temporal variations in aqueous phase chemistry, contaminant aging, mineralogy and organic matter. The presence of such heterogeneity may significantly influence DNAPL migration and entrapment in the saturated zone.
Williams, Greg; Tobler, Matthew; Gaffney, David; Moeller, John; Leavitt, Dennis D
2002-01-01
Computerized tomography (CT) is used routinely in evaluating radiation therapy isodose plans. With the introduction of 3D algorithms such as the voxel raytrace, which determines inhomogeneity corrections from actual CT Hounsfield numbers, caution must be used when evaluating isodose calculations. Artifacts from contrast media and dental work, radiopaque markers placed by the treatment planner, and changing bowel and rectal air patterns all have the potential to introduce error into the calculation due to inaccurate assessment of high or low density. Radiopaque makers such as x-spot BB's or solder wire are placed externally on the patient. Barium contrast media introduced at the time of simulation may be necessary to visualize specific anatomical structures on the CT images. While these localization and visualization tools may be necessary, it is important to understand the effects they may introduce in the planning process. Other problems encountered are patient specific and out of the control of the treatment planner. These include high- and low-density streaking caused by dental work, which produce computational errors due to overestimation, and small bowel and rectal air, the patterns of which change on a daily basis and may result in underestimation of structure density. It is important for each treatment planner to have an understanding of how this potentially tainted CT information may be applied in dose calculations and the possible effects they may have. At our institution, the voxel raytrace calculation is automatically forced any time couch angle is introduced. Errors in the calculation from the above mentioned situations may be introduced if a heterogeneity correction is applied. Examples of potential calculation errors and the magnitude of each will be discussed. The methods used to minimize these errors and the possible solutions will also be evaluated.
Carrasco, P.; Jornet, N.; Duch, M. A.; Panettieri, V.; Weber, L.; Eudaldo, T.; Ginjaume, M.; Ribas, M.
2007-08-15
To evaluate the dose values predicted by several calculation algorithms in two treatment planning systems, Monte Carlo (MC) simulations and measurements by means of various detectors were performed in heterogeneous layer phantoms with water- and bone-equivalent materials. Percentage depth doses (PDDs) were measured with thermoluminescent dosimeters (TLDs), metal-oxide semiconductor field-effect transistors (MOSFETs), plane parallel and cylindrical ionization chambers, and beam profiles with films. The MC code used for the simulations was the PENELOPE code. Three different field sizes (10x10, 5x5, and 2x2 cm{sup 2}) were studied in two phantom configurations and a bone equivalent material. These two phantom configurations contained heterogeneities of 5 and 2 cm of bone, respectively. We analyzed the performance of four correction-based algorithms and one based on convolution superposition. The correction-based algorithms were the Batho, the Modified Batho, the Equivalent TAR implemented in the Cadplan (Varian) treatment planning system (TPS), and the Helax-TMS Pencil Beam from the Helax-TMS (Nucletron) TPS. The convolution-superposition algorithm was the Collapsed Cone implemented in the Helax-TMS. All the correction-based calculation algorithms underestimated the dose inside the bone-equivalent material for 18 MV compared to MC simulations. The maximum underestimation, in terms of root-mean-square (RMS), was about 15% for the Helax-TMS Pencil Beam (Helax-TMS PB) for a 2x2 cm{sup 2} field inside the bone-equivalent material. In contrast, the Collapsed Cone algorithm yielded values around 3%. A more complex behavior was found for 6 MV where the Collapsed Cone performed less well, overestimating the dose inside the heterogeneity in 3%-5%. The rebuildup in the interface bone-water and the penumbra shrinking in high-density media were not predicted by any of the calculation algorithms except the Collapsed Cone, and only the MC simulations matched the experimental values
Barbaras, Sean A.; Knight, Travis W.
2012-07-01
composition whereas U-238, Pu-242, and Pu-238 composition was not changed by taking into account the non-homogenous lattice effects. Heterogeneous lattice effects do change the calculated eigenvalue and transmutation rate in a non-uniform lattice of MOX fuel rods and UO{sub 2} fuel. However, the uncertainty in the ENDF data used by SCALE in these calculations is large enough that the infinite lattice assumption remains valid. (authors)
Necessity of using heterogeneous ellipsoidal Earth model with terrain to calculate co-seismic effect
NASA Astrophysics Data System (ADS)
Cheng, Huihong; Zhang, Bei; Zhang, Huai; Huang, Luyuan; Qu, Wulin; Shi, Yaolin
2016-04-01
Co-seismic deformation and stress changes, which reflect the elasticity of the earth, are very important in the earthquake dynamics, and also to other issues, such as the evaluation of the seismic risk, fracture process and triggering of earthquake. Lots of scholars have researched the dislocation theory and co-seismic deformation and obtained the half-space homogeneous model, half-space stratified model, spherical stratified model, and so on. Especially, models of Okada (1992) and Wang (2003, 2006) are widely applied in the research of calculating co-seismic and post-seismic effects. However, since both semi-infinite space model and layered model do not take the role of the earth curvature or heterogeneity or topography into consideration, there are large errors in calculating the co-seismic displacement of a great earthquake in its impacted area. Meanwhile, the computational methods of calculating the co-seismic strain and stress are different between spherical model and plane model. Here, we adopted the finite element method which could well deal with the complex characteristics (such as anisotropy, discontinuities) of rock and different conditions. We use the mash adaptive technique to automatically encrypt the mesh at the fault and adopt the equivalent volume force replace the dislocation source, which can avoid the difficulty in handling discontinuity surface with conventional (Zhang et al., 2015). We constructed an earth model that included earth's layered structure and curvature, the upper boundary was set as a free surface and the core-mantle boundary was set under buoyancy forces. Firstly, based on the precision requirement, we take a testing model - - a strike-slip fault (the length of fault is 500km and the width is 50km, and the slippage is 10m) for example. Because of the curvature of the Earth, some errors certainly occur in plane coordinates just as previous studies (Dong et al., 2014; Sun et al., 2012). However, we also found that: 1) the co
Berginc, G
2013-11-30
We have developed a general formalism based on Green's functions to calculate the coherent electromagnetic field scattered by a random medium with rough boundaries. The approximate expression derived makes it possible to determine the effective permittivity, which is generalised for a layer of an inhomogeneous random medium with different types of particles and bounded with randomly rough interfaces. This effective permittivity describes the coherent propagation of an electromagnetic wave in a random medium with randomly rough boundaries. We have obtained an expression, which contains the Maxwell – Garnett formula at the low-frequency limit, and the Keller formula; the latter has been proved to be in good agreement with experiments for particles whose dimensions are larger than a wavelength. (coherent light scattering)
Study of the Surface Heterogeneity of icy dwarf?planets and other medium size Kuiper Belt objects
NASA Astrophysics Data System (ADS)
Pinilla-Alonso, Noemi; Emery, Josh P.
2015-10-01
We propose a comprehensive analysis of the surface heterogeneity of a selected sample of dwarf-planets and candidates to be considered as dwarf-planets. The sample has been carefully selected to reach the scientific goals with a relative low cost in observing time. The research proposed here will be based on the analysis of the light-curve of these objects obtained using IRAC/Spitzer photometry. KBOs likely retain some of the most primitive material in the Solar System. Models of the retention of volatiles by small-bodies in the Solar System show that dwarf-planets can retain most of the original inventory of volatiles. A good example is Pluto. The surface of this body is formed by patches of CH4, N2 and CO and exhibits a large degree of surface heterogeneity. Our preliminary results of the IRAC/Spitzer light curves of Pluto, obtained by this group in 2004 and 2014, show the potential of these data to map the surface distribution of the different species of ices on the surface of KBOs. For this project we have selected six objects (out of a list of 15) that are ideal for this study using Spitzer photometry. Our sample covers two classes of bodies: Eris, Makemake and Haumea, all large enough to retain volatiles and so how signs of sublimation and condensation cycles on their surfaces; and Quaoar, Varuna and Ixion (D<1000 km) that may not have retained volatiles. If signs of heterogeneity are detected on IRAC data from these medium bodies (as suggested by previous studies) this could be due to a combination of collisions and irradiation. By addressing the compositional heterogeneity of this sample of KBOs the proposed work will address gaps in the scientific knowledge of the chemical and dynamical history of the outer Solar System as well as other planetary systems.}
Field-scale experiments of unsaturated flow and solute transport in a heterogeneous porous medium
NASA Astrophysics Data System (ADS)
Nichol, Craig; Smith, Leslie; Beckie, Roger
2005-05-01
A multiyear flow and conservative tracer test has been carried out in unsaturated mine waste rock to examine the physical mechanisms by which water moves through this coarse, heterogeneous, granular material. The experimental system has a footprint of 8 m × 8 m, is 5 m high, and is built on a contiguous grid of 16 zero-tension lysimeters. A chloride tracer was applied during a single rainfall event. Subsequently, the system has been subject to both natural and applied rainfall events in which no further tracer was added. Water flow and tracer transport is monitored using in situ measurements of moisture content, matric suction, and soil water solution samplers. Results demonstrate for transient infiltration conditions the influence and interaction of matrix flow in a heterogeneous granular matrix, preferential flow in macropores, and noncapillary pathways. Tracer migration through preferential flow paths dominates the initial and peak breakthrough concentrations. Point measurements of tracer concentration from in situ solution samplers yield a relatively poor indication of the flux-averaged transport of mass that is recorded at the base of the experiment, in addition to overestimating the stored mass and underestimating residence time.
Uncertainty estimation in one-dimensional heat transport model for heterogeneous porous medium.
Chang, Ching-Min; Yeh, Hund-Der
2014-01-01
In many practical applications, the rates for ground water recharge and discharge are determined based on the analytical solution developed by Bredehoeft and Papadopulos (1965) to the one-dimensional steady-state heat transport equation. Groundwater flow processes are affected by the heterogeneity of subsurface systems; yet, the details of which cannot be anticipated precisely. There exists a great deal of uncertainty (variability) associated with the application of Bredehoeft and Papadopulos' solution (1965) to the field-scale heat transport problems. However, the quantification of uncertainty involved in such application has so far not been addressed, which is the objective of this wok. In addition, the influence of the statistical properties of log hydraulic conductivity field on the variability in temperature field in a heterogeneous aquifer is also investigated. The results of the analysis demonstrate that the variability (or uncertainty) in the temperature field increases with the correlation scale of the log hydraulic conductivity covariance function and the variability of temperature field also depends positively on the position.
SU-E-J-60: Efficient Monte Carlo Dose Calculation On CPU-GPU Heterogeneous Systems
Xiao, K; Chen, D. Z; Hu, X. S; Zhou, B
2014-06-01
Purpose: It is well-known that the performance of GPU-based Monte Carlo dose calculation implementations is bounded by memory bandwidth. One major cause of this bottleneck is the random memory writing patterns in dose deposition, which leads to several memory efficiency issues on GPU such as un-coalesced writing and atomic operations. We propose a new method to alleviate such issues on CPU-GPU heterogeneous systems, which achieves overall performance improvement for Monte Carlo dose calculation. Methods: Dose deposition is to accumulate dose into the voxels of a dose volume along the trajectories of radiation rays. Our idea is to partition this procedure into the following three steps, which are fine-tuned for CPU or GPU: (1) each GPU thread writes dose results with location information to a buffer on GPU memory, which achieves fully-coalesced and atomic-free memory transactions; (2) the dose results in the buffer are transferred to CPU memory; (3) the dose volume is constructed from the dose buffer on CPU. We organize the processing of all radiation rays into streams. Since the steps within a stream use different hardware resources (i.e., GPU, DMA, CPU), we can overlap the execution of these steps for different streams by pipelining. Results: We evaluated our method using a Monte Carlo Convolution Superposition (MCCS) program and tested our implementation for various clinical cases on a heterogeneous system containing an Intel i7 quad-core CPU and an NVIDIA TITAN GPU. Comparing with a straightforward MCCS implementation on the same system (using both CPU and GPU for radiation ray tracing), our method gained 2-5X speedup without losing dose calculation accuracy. Conclusion: The results show that our new method improves the effective memory bandwidth and overall performance for MCCS on the CPU-GPU systems. Our proposed method can also be applied to accelerate other Monte Carlo dose calculation approaches. This research was supported in part by NSF under Grants CCF
NASA Astrophysics Data System (ADS)
Luquet, David; Marchiano, Régis; Coulouvrat, François
2015-10-01
Many situations involve the propagation of acoustical shock waves through flows. Natural sources such as lightning, volcano explosions, or meteoroid atmospheric entries, emit loud, low frequency, and impulsive sound that is influenced by atmospheric wind and turbulence. The sonic boom produced by a supersonic aircraft and explosion noises are examples of intense anthropogenic sources in the atmosphere. The Buzz-Saw-Noise produced by turbo-engine fan blades rotating at supersonic speed also propagates in a fast flow within the engine nacelle. Simulating these situations is challenging, given the 3D nature of the problem, the long range propagation distances relative to the central wavelength, the strongly nonlinear behavior of shocks associated to a wide-band spectrum, and finally the key role of the flow motion. With this in view, the so-called FLHOWARD (acronym for FLow and Heterogeneous One-Way Approximation for Resolution of Diffraction) method is presented with three-dimensional applications. A scalar nonlinear wave equation is established in the framework of atmospheric applications, assuming weak heterogeneities and a slow wind. It takes into account diffraction, absorption and relaxation properties of the atmosphere, quadratic nonlinearities including weak shock waves, heterogeneities of the medium in sound speed and density, and presence of a flow (assuming a mean stratified wind and 3D turbulent ? flow fluctuations of smaller amplitude). This equation is solved in the framework of the one-way method. A split-step technique allows the splitting of the non-linear wave equation into simpler equations, each corresponding to a physical effect. Each sub-equation is solved using an analytical method if possible, and finite-differences otherwise. Nonlinear effects are solved in the time domain, and others in the frequency domain. Homogeneous diffraction is handled by means of the angular spectrum method. Ground is assumed perfectly flat and rigid. Due to the 3D
Luquet, David; Marchiano, Régis; Coulouvrat, François
2015-10-28
Many situations involve the propagation of acoustical shock waves through flows. Natural sources such as lightning, volcano explosions, or meteoroid atmospheric entries, emit loud, low frequency, and impulsive sound that is influenced by atmospheric wind and turbulence. The sonic boom produced by a supersonic aircraft and explosion noises are examples of intense anthropogenic sources in the atmosphere. The Buzz-Saw-Noise produced by turbo-engine fan blades rotating at supersonic speed also propagates in a fast flow within the engine nacelle. Simulating these situations is challenging, given the 3D nature of the problem, the long range propagation distances relative to the central wavelength, the strongly nonlinear behavior of shocks associated to a wide-band spectrum, and finally the key role of the flow motion. With this in view, the so-called FLHOWARD (acronym for FLow and Heterogeneous One-Way Approximation for Resolution of Diffraction) method is presented with three-dimensional applications. A scalar nonlinear wave equation is established in the framework of atmospheric applications, assuming weak heterogeneities and a slow wind. It takes into account diffraction, absorption and relaxation properties of the atmosphere, quadratic nonlinearities including weak shock waves, heterogeneities of the medium in sound speed and density, and presence of a flow (assuming a mean stratified wind and 3D turbulent ? flow fluctuations of smaller amplitude). This equation is solved in the framework of the one-way method. A split-step technique allows the splitting of the non-linear wave equation into simpler equations, each corresponding to a physical effect. Each sub-equation is solved using an analytical method if possible, and finite-differences otherwise. Nonlinear effects are solved in the time domain, and others in the frequency domain. Homogeneous diffraction is handled by means of the angular spectrum method. Ground is assumed perfectly flat and rigid. Due to the 3D
Garcia-Herranz, Nuria; Cabellos, Oscar; Aragones, Jose M.; Ahnert, Carol
2003-05-15
In order to take into account in a more effective and accurate way the intranodal heterogeneities in coarse-mesh finite-difference (CMFD) methods, a new equivalent parameter generation methodology has been developed and tested. This methodology accounts for the dependence of the nodal homogeneized two-group cross sections and nodal coupling factors, with interface flux discontinuity (IFD) factors that account for heterogeneities on the flux-spectrum and burnup intranodal distributions as well as on neighbor effects.The methodology has been implemented in an analytic CMFD method, rigorously obtained for homogeneous nodes with transverse leakage and generalized now for heterogeneous nodes by including IFD heterogeneity factors. When intranodal mesh node heterogeneity vanishes, the heterogeneous solution tends to the analytic homogeneous nodal solution. On the other hand, when intranodal heterogeneity increases, a high accuracy is maintained since the linear and nonlinear feedbacks on equivalent parameters have been shown to be as a very effective way of accounting for heterogeneity effects in two-group multidimensional coarse-mesh diffusion calculations.
NASA Astrophysics Data System (ADS)
Mishra, S.; Schwab, Ch.; Šukys, J.
2016-05-01
We consider the very challenging problem of efficient uncertainty quantification for acoustic wave propagation in a highly heterogeneous, possibly layered, random medium, characterized by possibly anisotropic, piecewise log-exponentially distributed Gaussian random fields. A multi-level Monte Carlo finite volume method is proposed, along with a novel, bias-free upscaling technique that allows to represent the input random fields, generated using spectral FFT methods, efficiently. Combined together with a recently developed dynamic load balancing algorithm that scales to massively parallel computing architectures, the proposed method is able to robustly compute uncertainty for highly realistic random subsurface formations that can contain a very high number (millions) of sources of uncertainty. Numerical experiments, in both two and three space dimensions, illustrating the efficiency of the method are presented.
Munir, A.; Hensel, O.; Scheffler, W.
2010-08-15
Scheffler fixed focus concentrators are successfully used for medium temperature applications in different parts of the world. These concentrators are taken as lateral sections of paraboloids and provide fixed focus away from the path of incident beam radiations throughout the year. The paper presents a complete description about the design principle and construction details of an 8 m{sup 2} surface area Scheffler concentrator. The first part of the paper presents the mathematical calculations to design the reflector parabola curve and reflector elliptical frame with respect to equinox (solar declination = 0) by selecting a specific lateral part of a paraboloid. Crossbar equations and their ellipses, arc lengths and their radii are also calculated to form the required lateral section of the paraboloid. Thereafter, the seasonal parabola equations are calculated for two extreme positions of summer and winter in the northern hemisphere (standing reflectors). The slopes of the parabola equations for equinox (solar declination = 0), summer (solar declination = +23.5) and winter (solar declination = -23.5) for the Scheffler reflector (8 m{sup 2} surface area) are calculated to be 0.17, 0.28, and 0.13 respectively. The y-intercepts of the parabola equations for equinox, summer and winter are calculated as 0, 0.54, and -0.53 respectively. By comparing with the equinox parabola curve, the summer parabola is found to be smaller in size and uses the top part of the parabola curve while the winter parabola is bigger in size and uses the lower part of the parabola curve to give the fixed focus. For this purpose, the reflector assembly is composed of flexible crossbars and a frame to induce the required change of the parabola curves with the changing solar declination. The paper also presents the calculation procedure of seasonal parabola equations for standing reflectors in the southern hemisphere as well as for laying reflectors in the northern and southern hemispheres. Highly
Non local Lotka-Volterra system with cross-diffusion in an heterogeneous medium.
Fontbona, Joaquin; Méléard, Sylvie
2015-03-01
We introduce a stochastic individual model for the spatial behavior of an animal population of dispersive and competitive species, considering various kinds of biological effects, such as heterogeneity of environmental conditions, mutual attractive or repulsive interactions between individuals or competition between them for resources. As a consequence of the study of the large population limit, global existence of a nonnegative weak solution to a multidimensional parabolic strongly coupled model of competing species is proved. The main new feature of the corresponding integro-differential equation is the nonlocal nonlinearity appearing in the diffusion terms, which may depend on the spatial densities of all population types. Moreover, the diffusion matrix is generally not strictly positive definite and the cross-diffusion effect allows for influences growing linearly with the subpopulations' sizes. We prove uniqueness of the finite measure-valued solution and give conditions under which the solution takes values in a functional space. We then make the competition kernels converge to a Dirac measure and obtain the existence of a solution to a locally competitive version of the previous equation. The techniques are essentially based on the underlying stochastic flow related to the dispersive part of the dynamics, and the use of suitable dual distances in the space of finite measures.
Non local Lotka-Volterra system with cross-diffusion in an heterogeneous medium.
Fontbona, Joaquin; Méléard, Sylvie
2015-03-01
We introduce a stochastic individual model for the spatial behavior of an animal population of dispersive and competitive species, considering various kinds of biological effects, such as heterogeneity of environmental conditions, mutual attractive or repulsive interactions between individuals or competition between them for resources. As a consequence of the study of the large population limit, global existence of a nonnegative weak solution to a multidimensional parabolic strongly coupled model of competing species is proved. The main new feature of the corresponding integro-differential equation is the nonlocal nonlinearity appearing in the diffusion terms, which may depend on the spatial densities of all population types. Moreover, the diffusion matrix is generally not strictly positive definite and the cross-diffusion effect allows for influences growing linearly with the subpopulations' sizes. We prove uniqueness of the finite measure-valued solution and give conditions under which the solution takes values in a functional space. We then make the competition kernels converge to a Dirac measure and obtain the existence of a solution to a locally competitive version of the previous equation. The techniques are essentially based on the underlying stochastic flow related to the dispersive part of the dynamics, and the use of suitable dual distances in the space of finite measures. PMID:24710661
NASA Technical Reports Server (NTRS)
Rich, A.; Van House, J.; Hegstrom, R. A.
1982-01-01
A dynamical calculation is presented of the helicity induced in an initially unpolarized electron beam after elastic scattering from an optically active medium, a process analogous to the circular polarization induced in unpolarized light following Rayleigh scattering from chiral targets. The calculation is based on the bound helical electron model of a chiral molecule, according to which the major contribution to the helicity is provided by the perturbation of the electron bound state by the spin-orbit interaction of the bound electrons moving in the electric field of the molecular core. The net helicity acquired is found to depend directly on a molecular asymmetry factor and the square of the atomic number of the heaviest atom in an asymmetric environment. For the case of carbon, the induced helicity is on the order of 0.00001, which would account for its lack of observation in a recent experiment. Results may have implications for the origin of optical activity in biological molecules by the differential ionization of D and L isomers by beta-decay electrons.
SU-F-19A-01: APBI Brachytherapy Treatment Planning: The Impact of Heterogeneous Dose Calculations
Loupot, S; Han, T; Salehpour, M; Gifford, K
2014-06-15
Purpose: To quantify the difference in dose to PTV-EVAL and OARs (skin and rib) as calculated by (TG43) and heterogeneous calculations (CCC). Methods: 25 patient plans (5 Contura and 20 SAVI) were selected for analysis. Clinical dose distributions were computed with a commercially available treatment planning algorithm (TG43-D-(w,w)) and then recomputed with a pre-clinical collapsed cone convolution algorithm (CCCD-( m,m)). PTV-EVAL coverage (V90%, V95%), and rib and skin maximum dose were compared via percent difference. Differences in dose to normal tissue (V150cc, V200cc of PTV-EVAL) were also compared. Changes in coverage and maximum dose to organs at risk are reported in percent change, (100*(TG43 − CCC) / TG43)), and changes in maximum dose to normal tissue are absolute change in cc (TG43 − CCC). Results: Mean differences in V90, V95, V150, and V200 for the SAVI cases were −0.2%, −0.4%, −0.03cc, and −0.14cc, respectively, with maximum differences of −0.78%, −1.7%, 1.28cc, and 1.01cc, respectively. Mean differences in the 0.1cc dose to the rib and skin were −1.4% and −0.22%, respectively, with maximum differences of −4.5% and 16%, respectively. Mean differences in V90, V95, V150, and V200 for the Contura cases were −1.2%, −2.1%, −1.8cc, and −0.59cc, respectively, with maximum differences of −2.0%, −3.16%, −2.9cc, and −0.76cc, respectively. Mean differences in the 0.1cc dose to the rib and skin were −2.6% and −3.9%, respectively, with maximum differences of −3.2% and −5.7%, respectively. Conclusion: The effects of translating clinical knowledge based on D-(w,w) to plans reported in D-(m,m) are minimal (2% or less) on average, but vary based on the type and placement of the device, source, and heterogeneity information.
Comparison of theory and experiment for solute transport in highly heterogeneous porous medium
NASA Astrophysics Data System (ADS)
Golfier, Fabrice; Quintard, Michel; Cherblanc, Fabien; Zinn, Brendan A.; Wood, Brian D.
2007-11-01
In this work we compare the recently developed two-region mass transfer theory reported by Ahmadi et al. [A. Ahmadi, M. Quintard, S. Whitaker (1998), Transport in chemically and mechanically heterogeneous porous media, V, two-equation model for solute transport with adsorption, Adv. Water Resour. 1998;22:59-86] with experimental results reported by Zinn et al. [Zinn, B., L. C. Meigs, C. F. Harvey, R. Haggerty, W. J. Peplinski, C. F. Von Schwerin. Experimental visualization of solute transport and mass transfer processes in two-dimensional conductivity fields with connected regions of high conductivity. Environ Sci Technol 2004;38:3916-3926]. We find that the constant mass transfer coefficient predicted by the steady-state closure to the theory, when used with the macroscale transport equation, provides a reasonable prediction of the observed breakthrough curve. However, the use of a constant mass transfer coefficient does not allow good representation of the tailing that is observed in the data. We show that the mass transfer coefficient can be represented in terms of the eigenvalue expansion of a Green's function. For a steady solution to the closure problem, this expansion leads to the effective mass transfer coefficient being defined in terms of the harmonic average of the eigenvalues of the expansion; this is consistent with previous work on this topic. To further investigate the influence of using a single, constant value for the mass transfer coefficient, we examine the solution to the mass transfer problem in terms of a mixed model, where the eigenvalues of one region (the inclusions) are kept, while the second region (the matrix) is treated as a homogenized material. The results from this comparison indicate that the mass transfer coefficient predicted via volume averaging using a quasi-steady closure could potentially be improved upon by development of new methods that retain more of the eigenvalues of the system.
Kan, Monica W. K.; Leung, Lucullus H. T.; So, Ronald W. K.; Yu, Peter K. N.
2013-03-15
Purpose: To compare the doses calculated by the Acuros XB (AXB) algorithm and analytical anisotropic algorithm (AAA) with experimentally measured data adjacent to and within heterogeneous medium using intensity modulated radiation therapy (IMRT) and RapidArc{sup Registered-Sign} (RA) volumetric arc therapy plans for nasopharygeal carcinoma (NPC). Methods: Two-dimensional dose distribution immediately adjacent to both air and bone inserts of a rectangular tissue equivalent phantom irradiated using IMRT and RA plans for NPC cases were measured with GafChromic{sup Registered-Sign} EBT3 films. Doses near and within the nasopharygeal (NP) region of an anthropomorphic phantom containing heterogeneous medium were also measured with thermoluminescent dosimeters (TLD) and EBT3 films. The measured data were then compared with the data calculated by AAA and AXB. For AXB, dose calculations were performed using both dose-to-medium (AXB{sub Dm}) and dose-to-water (AXB{sub Dw}) options. Furthermore, target dose differences between AAA and AXB were analyzed for the corresponding real patients. The comparison of real patient plans was performed by stratifying the targets into components of different densities, including tissue, bone, and air. Results: For the verification of planar dose distribution adjacent to air and bone using the rectangular phantom, the percentages of pixels that passed the gamma analysis with the {+-} 3%/3mm criteria were 98.7%, 99.5%, and 97.7% on the axial plane for AAA, AXB{sub Dm}, and AXB{sub Dw}, respectively, averaged over all IMRT and RA plans, while they were 97.6%, 98.2%, and 97.7%, respectively, on the coronal plane. For the verification of planar dose distribution within the NP region of the anthropomorphic phantom, the percentages of pixels that passed the gamma analysis with the {+-} 3%/3mm criteria were 95.1%, 91.3%, and 99.0% for AAA, AXB{sub Dm}, and AXB{sub Dw}, respectively, averaged over all IMRT and RA plans. Within the NP region where
Fekete, Charles-Antoine Collins; Doolan, Paul; Dias, Marta F; Beaulieu, Luc; Seco, Joao
2015-07-01
To develop an accurate phenomenological model of the cubic spline path estimate of the proton path, accounting for the initial proton energy and water equivalent thickness (WET) traversed. Monte Carlo (MC) simulations were used to calculate the path of protons crossing various WET (10-30 cm) of different material (LN300, water and CB2-50% CaCO3) for a range of initial energies (180-330 MeV). For each MC trajectory, cubic spline trajectories (CST) were constructed based on the entrance and exit information of the protons and compared with the MC using the root mean square (RMS) metric. The CST path is dependent on the direction vector magnitudes (|P0,1|). First, |P0,1| is set to the proton path length (with factor Λ(Norm)(0,1) = 1.0). Then, two optimal factor Λ(0,1) are introduced in |P0,1|. The factors are varied to minimize the RMS difference with MC paths for every configuration. A set of Λ(opt)(0,1) factors, function of WET/water equivalent path length (WEPL), that minimizes the RMS are presented. MTF analysis is then performed on proton radiographs of a line-pair phantom reconstructed using the CST trajectories. Λ(opt)(0,1) was fitted to the WET/WEPL ratio using a quadratic function (Y = A + BX(2) where A = 1.01,0.99, B = 0.43,- 0.46 respectively for Λ(opt)(0), Λ(opt)(1)). The RMS deviation calculated along the path, between the CST and the MC, increases with the WET. The increase is larger when using Λ(Norm)(0,1) than Λ(opt)(0,1) (difference of 5.0% with WET/WEPL = 0.66). For 230/330 MeV protons, the MTF10% was found to increase by 40/16% respectively for a thin phantom (15 cm) when using the Λ(opt)(0,1) model compared to the Λ(Norm)(0,1) model. Calculation times for Λ(opt)(0,1) are scaled down compared to MLP and RMS deviation are similar within standard deviation.B ased on the results of this study, using CST with the Λ(opt)(0,1) factors reduces the RMS deviation and increases the spatial resolution when reconstructing proton
Fekete, Charles-Antoine Collins; Doolan, Paul; Dias, Marta F; Beaulieu, Luc; Seco, Joao
2015-07-01
To develop an accurate phenomenological model of the cubic spline path estimate of the proton path, accounting for the initial proton energy and water equivalent thickness (WET) traversed. Monte Carlo (MC) simulations were used to calculate the path of protons crossing various WET (10-30 cm) of different material (LN300, water and CB2-50% CaCO3) for a range of initial energies (180-330 MeV). For each MC trajectory, cubic spline trajectories (CST) were constructed based on the entrance and exit information of the protons and compared with the MC using the root mean square (RMS) metric. The CST path is dependent on the direction vector magnitudes (|P0,1|). First, |P0,1| is set to the proton path length (with factor Λ(Norm)(0,1) = 1.0). Then, two optimal factor Λ(0,1) are introduced in |P0,1|. The factors are varied to minimize the RMS difference with MC paths for every configuration. A set of Λ(opt)(0,1) factors, function of WET/water equivalent path length (WEPL), that minimizes the RMS are presented. MTF analysis is then performed on proton radiographs of a line-pair phantom reconstructed using the CST trajectories. Λ(opt)(0,1) was fitted to the WET/WEPL ratio using a quadratic function (Y = A + BX(2) where A = 1.01,0.99, B = 0.43,- 0.46 respectively for Λ(opt)(0), Λ(opt)(1)). The RMS deviation calculated along the path, between the CST and the MC, increases with the WET. The increase is larger when using Λ(Norm)(0,1) than Λ(opt)(0,1) (difference of 5.0% with WET/WEPL = 0.66). For 230/330 MeV protons, the MTF10% was found to increase by 40/16% respectively for a thin phantom (15 cm) when using the Λ(opt)(0,1) model compared to the Λ(Norm)(0,1) model. Calculation times for Λ(opt)(0,1) are scaled down compared to MLP and RMS deviation are similar within standard deviation.B ased on the results of this study, using CST with the Λ(opt)(0,1) factors reduces the RMS deviation and increases the spatial resolution when reconstructing proton
Mirbagheri, Seyed Amir; Fu, Henry Chien
2016-05-13
Helicobacter pylori swims through mucus gel by generating ammonia that locally neutralizes the acidic gastric environment, turning nearby gel into a fluid pocket. The size of the fluid zone is important for determining the physics of the motility: in a large zone swimming occurs as in a fluid through hydrodynamic principles, while in a very small zone the motility could be strongly influenced by nonhydrodynamic cell-mucus interactions including chemistry and adhesion. Here, we calculate the size of the fluid pocket. We model how swimming depends on the de-gelation range using a Taylor sheet swimming through a layer of Newtonian fluid bounded by a Brinkman fluid. Then, we model how the de-gelation range depends on the swimming speed by considering the advection-diffusion of ammonia exuded from a translating sphere. Self-consistency between both models determines the values of the swimming speed and the de-gelation range. We find that H. pylori swims through mucus as if unconfined, in a large pocket of Newtonian fluid. PMID:27232048
NASA Astrophysics Data System (ADS)
Mirbagheri, Seyed Amir; Fu, Henry Chien
2016-05-01
Helicobacter pylori swims through mucus gel by generating ammonia that locally neutralizes the acidic gastric environment, turning nearby gel into a fluid pocket. The size of the fluid zone is important for determining the physics of the motility: in a large zone swimming occurs as in a fluid through hydrodynamic principles, while in a very small zone the motility could be strongly influenced by nonhydrodynamic cell-mucus interactions including chemistry and adhesion. Here, we calculate the size of the fluid pocket. We model how swimming depends on the de-gelation range using a Taylor sheet swimming through a layer of Newtonian fluid bounded by a Brinkman fluid. Then, we model how the de-gelation range depends on the swimming speed by considering the advection-diffusion of ammonia exuded from a translating sphere. Self-consistency between both models determines the values of the swimming speed and the de-gelation range. We find that H. pylori swims through mucus as if unconfined, in a large pocket of Newtonian fluid.
NASA Astrophysics Data System (ADS)
Shanafield, M.; Cook, P. G.; McCallum, J.; Noorduijn, S.
2013-12-01
capturing and quantifying streambed heterogeneity at a medium scale.
Stavropoulou, Despoina Angeliki; Borremans, Wim; De Vuyst, Luc; De Smet, Stefaan; Leroy, Frédéric
2015-11-01
The ability of coagulase-negative staphylococci (CNS) to convert amino acids into volatile compounds and biogenic amines was investigated after 24h and 48 h of incubation in a rich medium (brain heart infusion). Volatile compounds were measured with static-headspace gas chromatography and mass spectrometry (SH-GC-MS); biogenic amine measurements were carried out with a newly developed method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). In total, 56 CNS strains from five different species were used, namely Staphylococcus carnosus, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus saprophyticus, and Staphylococcus xylosus. With respect to the production of volatile compounds, the leucine-derived 3-methyl butanol was produced over time by most CNS strains, up to 52 μM for S. xylosus W1-1 after 48 h of incubation. The average production by strains of S. xylosus was significantly higher than for strains of S. carnosus, whereas strains of S. epidermidis turned out to be poor producers. Yet, differences between species were blurred to a large degree because of the high strain variability. A few strains also produced 3-methyl butanal on top of the amount that was already present in the medium background, although most CNS led to a decrease of this compound. Concerning biogenic amines, the average total concentrations per species remained below 100 μM after 48 h of incubation. The most abundant variant was 2-phenylethylamine (PEA), especially within S. carnosus (average of 65 μM after 48 h of incubation). Yet, some individual strains were able to produce higher concentrations, as found for the PEA production of 295 μM by S. epidermidis ATCC 12228 after 48 h of incubation. The insights obtained during this study indicate heterogeneity and are of importance in view of both starter culture development and the evaluation of a spontaneously established CNS microbiota in artisan-type meat fermentations
NASA Technical Reports Server (NTRS)
Tanimoto, T.
1984-01-01
A simple modification of Gilbert's formula to account for slight lateral heterogeneity of the earth leads to a convenient formula to calculate synthetic long period seismograms. Partial derivatives are easily calculated, thus the formula is suitable for direct inversion of seismograms for lateral heterogeneity of the earth. Previously announced in STAR as N83-29893
NASA Technical Reports Server (NTRS)
Tanimoto, T.
1983-01-01
A simple modification of Gilbert's formula to account for slight lateral heterogeneity of the Earth leads to a convenient formula to calculate synthetic long period seismograms. Partial derivatives are easily calculated, thus the formula is suitable for direct inversion of seismograms for lateral heterogeneity of the Earth.
NASA Astrophysics Data System (ADS)
Oostrom, M.; Hofstee, C.; Walker, R. C.; Dane, J. H.
1999-04-01
An intermediate-scale flow cell experiment was conducted to remove a liquid trichloroethylene (TCE) spill from a saturated, heterogeneous porous medium using pump-and-treat (P&T) as well as surfactant flushing (SF) techniques. Dissolved TCE concentrations were measured at 20 locations, while fluid saturations were obtained with a dual-energy gamma scanner. The behavior of the TCE spill has been described by Oostrom et al. (1998b) [Oostrom, M., Hofstee, C., Walker, R.C., Dane, J.H., 1998b. Movement and remediation of TCE in a saturated heterogeneous porous medium: 1. Spill behavior and initial dissolution, this issue.]. A total of six alternating P&T and SF periods were used to remediate the flow cell. A two-well system, consisting of an injection and an extraction well, was used during the first five remediation periods. For the last SF period, a three-well system was employed with two injection wells and one extraction well. During the first P&T period, most entrapped TCE was removed, but TCE saturations in a substantial pool on top of a fine-grained sand layer were largely unaffected. During the first SF period, a dense plume was formed containing solubilized TCE which partially sank into the fine-grained sand. In addition, unstable fingers developed below the liquid TCE in the pool. In several samples, small TCE droplets were found, indicating mobilization of TCE. Most of the samples with concentrations larger than 5000 ppm had a milky, emulsion-like appearance. The SF considerably reduced the amount of TCE in the pool on top of the fine-grained sand. During the second P&T period, plume sinking and instabilities were not observed. After starting the second SF period, some unstable fingering and plume sinking resumed, starting at the upstream end of the TCE in the pool. The saturation distribution obtained after the second SF period was quite similar to the one obtained after the first SF period, indicating that additional removal of TCE through SF was difficult
ERIC Educational Resources Information Center
Luh, Wei-Ming; Guo, Jiin-Huarng
2011-01-01
Sample size determination is an important issue in planning research. In the context of one-way fixed-effect analysis of variance, the conventional sample size formula cannot be applied for the heterogeneous variance cases. This study discusses the sample size requirement for the Welch test in the one-way fixed-effect analysis of variance with…
NASA Astrophysics Data System (ADS)
RamReddy, Chetteti; Pradeepa, Teegala
2016-05-01
Based on the nonlinear variation of density with temperature (NDT) in the buoyancy term, the mixed convection flow along a vertical plate of a micropolar fluid saturated porous medium is considered. In addition, the effect of homogeneous-heterogeneous reaction and convective boundary condition has been taken into account. Using lie scaling group transformations, the similarity representation is attained for the system of partial differential equations, prior to being solved by a spectral quasilinearization method. The results show that in the presence of aiding and opposing flow situations, both the species concentration and mass transfer rate decreases when the strength of homogeneous and heterogeneous reaction parameters are enhanced.
NASA Astrophysics Data System (ADS)
Haija, A. J.; Larry Freeman, W.; Umbel, Rachel
2011-11-01
This article presents a review of several aspects of the characteristic effective medium approximation that has been used to calculate the optical properties of ultrathin multilayer systems treated as one uniform layer with a single set of effective optical constants. The method, applied for normal incidence, enables one to represent any layer stack by one characteristic matrix whose elements are functions of the structure effective optical constants, stack thickness, and wavelength of the incident light wave. The error between values of the optical properties of a layer system calculated by the standard characteristic matrix technique and those calculated by the characteristic effective matrix approximation can be used as a criterion for establishing a limit beyond which the validity of the approximation could be compromised. As part of this grand review, calculations of the optical properties for normal incidence for numerous layer systems that were reported earlier in separate communications, are reviewed and analyzed.
NASA Astrophysics Data System (ADS)
Maryana, Okky Fajar Tri; Hidayat, Rahmat
2016-08-01
Finite Difference Time Domain (FDTD) method has been much employed for studying light propagation in various structures, from simple one-dimensional structures up to three-dimensional complex structures. One of challenging problems is to implement this method for the case of light propagation in amplifying medium or structures, such as optical amplifier and lasers. The implementation is hindered by the fact that the dielectric constant becomes a complex number when optical gain parameter is involved in the calculation. In general, complex dielectric constant is related to complex susceptibility, in which the imaginary part is related to optical gain. Here, we then modify the formulation for updating electric field in the calculation algorithm. Using this approach, we then finally can calculate light amplification in laser active medium of Nd3+ ion doped glass. The calculation result shows an agreement with the result from the calculation using differential equation for intensity. Although this method is more time consuming, the method seem promising for optical complex micro- and nano-structures, such quantum dot lasers, micro-ring lasers, etc.
NASA Astrophysics Data System (ADS)
Ohkawauchi, K.; Takenaka, H.
2006-12-01
We propose a new method for the calculation of seismic wave propagation using the interpolated differential operator (IDO, Aoki,1997) which is a numerical method for solving the partial differential equations and is based on a high accurate interpolation of the profile for the independent variables over a local area. It improves the accuracy of wave computation with high accuracy because the local interpolation can represent high order behavior of wave field between grid points. In addition, locality of this approach makes possible treatment of boundary conditions exactly. In this study, we address computation of plane-wave responses of vertically heterogeneous structure models. We then solve the elastodynamic equation for plane wave derived by Tanaka and Takenaka (2005). The equations to be solved in our method are not only velocity-stress equations but also the corresponding ones integrated over each cell between adjacent grid points. We use two staggered-grid systems which can be non-uniform, and then discretize the governing equations using a finite-difference scheme of second-order accurate in time, and the second-order Hermite interpolation in space. In this method, the second-order Hermite interpolation of particle velocity or stress is obtained from the values at the adjacent two grid points and the integration value at the cell between the grid points. The time marching of the original and integrated quantities are proceeded, and in the following time step the quantities are computed on the alternative grid system to that used in the current time step. In implementation of a free-surface boundary condition, all field quantities locate just on the free surface. Their computational accuracy is the same order as those in the other spatial domain. We also implement the interface condition in a similarly way to the free surface condition. We used some simple models to test the scheme. The results showed that the waveforms calculated by our method fit the
Mikell, Justin K.; Klopp, Ann H.; Gonzalez, Graciela M.N.; Kisling, Kelly D.; Price, Michael J.; Berner, Paula A.; Eifel, Patricia J.; Mourtada, Firas
2012-07-01
Purpose: To investigate the dosimetric impact of the heterogeneity dose calculation Acuros (Transpire Inc., Gig Harbor, WA), a grid-based Boltzmann equation solver (GBBS), for brachytherapy in a cohort of cervical cancer patients. Methods and Materials: The impact of heterogeneities was retrospectively assessed in treatment plans for 26 patients who had previously received {sup 192}Ir intracavitary brachytherapy for cervical cancer with computed tomography (CT)/magnetic resonance-compatible tandems and unshielded colpostats. The GBBS models sources, patient boundaries, applicators, and tissue heterogeneities. Multiple GBBS calculations were performed with and without solid model applicator, with and without overriding the patient contour to 1 g/cm{sup 3} muscle, and with and without overriding contrast materials to muscle or 2.25 g/cm{sup 3} bone. Impact of source and boundary modeling, applicator, tissue heterogeneities, and sensitivity of CT-to-material mapping of contrast were derived from the multiple calculations. American Association of Physicists in Medicine Task Group 43 (TG-43) guidelines and the GBBS were compared for the following clinical dosimetric parameters: Manchester points A and B, International Commission on Radiation Units and Measurements (ICRU) report 38 rectal and bladder points, three and nine o'clock, and {sub D2cm3} to the bladder, rectum, and sigmoid. Results: Points A and B, D{sub 2} cm{sup 3} bladder, ICRU bladder, and three and nine o'clock were within 5% of TG-43 for all GBBS calculations. The source and boundary and applicator account for most of the differences between the GBBS and TG-43 guidelines. The D{sub 2cm3} rectum (n = 3), D{sub 2cm3} sigmoid (n = 1), and ICRU rectum (n = 6) had differences of >5% from TG-43 for the worst case incorrect mapping of contrast to bone. Clinical dosimetric parameters were within 5% of TG-43 when rectal and balloon contrast were mapped to bone and radiopaque packing was not overridden. Conclusions
NASA Astrophysics Data System (ADS)
Krieger, Thomas; Sauer, Otto A.
2005-03-01
The aim of this work was to evaluate the accuracy of dose predicted in heterogeneous media by a pencil beam (PB), a collapsed cone (CC) and a Monte Carlo (MC) algorithm. For this purpose, a simple multi-layer phantom composed of Styrofoam and white polystyrene was irradiated with 10 × 10 cm2 as well as 20 × 20 cm2 open 6 MV photon fields. The beam axis was aligned parallel to the layers and various field offsets were applied. Thereby, the amount of lateral scatter was controlled. Dose measurements were performed with an ionization chamber positioned both in the central layer of white polystyrene and the adjacent layers of Styrofoam. It was found that, in white polystyrene, both MC and CC calculations agreed satisfactorily with the measurements whereas the PB algorithm calculated 12% higher doses on average. By studying off-axis dose profiles the observed differences in the calculation results increased dramatically for the three algorithms. In the regions of low density CC calculated 10% (8%) lower doses for the 10 × 10 cm2 (20 × 20 cm2) fields than MC. The MC data on the other hand agreed well with the measurements, presuming that proper replacement correction for the ionization chamber embedded in Styrofoam was performed. PB results evidently did not account for the scattering geometry and were therefore not really comparable. Our investigations showed that the PB algorithm generates very large errors for the dose in the vicinity of interfaces and within low-density regions. We also found that for the used CC algorithm large deviations for the absolute dose (dose/monitor unit) occur in regions of electronic disequilibrium. The performance might be improved by better adapted parameters. Therefore, we recommend a careful investigation of the accuracy for dose calculations in heterogeneous media for each beam data set and algorithm.
SU-E-T-162: Evaluation of Dose Calculation of RayStation Planning System in Heterogeneous Media
Xu, H; Yi, B; Chung, H; Prado, K; Chen, S
2014-06-01
Purpose: To investigate the clinical reliability of heterogeneity-based dose algorithm using RayStation treatment planning system v.4.0. Methods: The collapsed cone dose calculations in RayStation (RaySearch, Sweden) were compared with the measurements (ion chamber and EBT2 film) and with an in-house Monte Carlo algorithm. A heterogeneous multi-layer phantom and CT images of 4 lung cancer patients were used here. The phantom, composed of multiple solid water slabs and Styrofoams, was irradiated with 6MV beams perpendicular to the layers. The MLC-defined field sizes were 5×5, 10×10, 15×15 and 20×20cm{sup 2}. The chamber was positioned at center of central solid water layer, and the films were placed at interfaces of solid water and Styrofoam. The RayStation dose and Monte Carlo dose were compared by performing absolute gamma analysis (3mm/3%): 1D gamma for PDD in the phantom and 3D gamma for patient volumes receiving dose above 10% of maximum dose. Results: The point dose differences between RayStation and ion chamber measurement were smaller than 1% for all of the field sizes. Between RayStation and film measurement, 5×5cm2 field had the maximum differences : <4mm for the penumbra and <0.3mm for the field width at all Styrofoam-and-solid-water interfaces. The absolute gamma analysis showed good agreement between RayStation and Monte Carlo. For PDD along beam axis in the phantom, the 1D gamma was 95.4, 98.6, 99.6 and 99.3% for field size 5×5, 10×10, 15×15 and 20×202 respectively. For dose comparison using patient CT images, 3D gamma was > 95% for all the patients. Conclusion: With respect to ion chamber/film measurement and Monte Carlo calculation, the collapsed cone algorithm in RayStation computed reasonable dose in both phantom and patient cases. Heterogeneity-based dose calculation of RayStation is clinically acceptable in heterogeneous media.
NASA Astrophysics Data System (ADS)
Jung, Hyunuk; Kum, Oyeon; Han, Youngyih; Park, Byungdo; Cheong, Kwang-Ho
2014-12-01
For a better understanding of the accuracy of state-of-the-art-radiation therapies, 2-dimensional dosimetry in a patient-like environment will be helpful. Therefore, the dosimetry of EBT3 films in non-water-equivalent tissues was investigated, and the accuracy of commercially-used dose-calculation algorithms was evaluated with EBT3 measurement. Dose distributions were measured with EBT3 films for an in-house-designed phantom that contained a lung or a bone substitute, i.e., an air cavity (3 × 3 × 3 cm3) or teflon (2 × 2 × 2 cm3 or 3 × 3 × 3 cm3), respectively. The phantom was irradiated with 6-MV X-rays with field sizes of 2 × 2, 3 × 3, and 5 × 5 cm2. The accuracy of EBT3 dosimetry was evaluated by comparing the measured dose with the dose obtained from Monte Carlo (MC) simulations. A dose-to-bone-equivalent material was obtained by multiplying the EBT3 measurements by the stopping power ratio (SPR). The EBT3 measurements were then compared with the predictions from four algorithms: Monte Carlo (MC) in iPlan, acuros XB (AXB), analytical anisotropic algorithm (AAA) in Eclipse, and superposition-convolution (SC) in Pinnacle. For the air cavity, the EBT3 measurements agreed with the MC calculation to within 2% on average. For teflon, the EBT3 measurements differed by 9.297% (±0.9229%) on average from the Monte Carlo calculation before dose conversion, and by 0.717% (±0.6546%) after applying the SPR. The doses calculated by using the MC, AXB, AAA, and SC algorithms for the air cavity differed from the EBT3 measurements on average by 2.174, 2.863, 18.01, and 8.391%, respectively; for teflon, the average differences were 3.447, 4.113, 7.589, and 5.102%. The EBT3 measurements corrected with the SPR agreed with 2% on average both within and beyond the heterogeneities with MC results, thereby indicating that EBT3 dosimetry can be used in heterogeneous media. The MC and the AXB dose calculation algorithms exhibited clinically-acceptable accuracy (<5%) in
Numerical Laplace transform density of states calculation for medium and large molecules
NASA Astrophysics Data System (ADS)
Romanini, D.; Lehmann, K. K.
1993-04-01
A novel implementation of the Laplace transform method for the calculation of the density of states of molecules, for which the partition function can be explicitly given is described. It consists of doing the inverse Laplace transform numerically after multiplying the integrand by a smoothing factor. This evaluation is more accurate than the method of steepest descent, and the computation can still be done on a PC in a few minutes. By first order expansion of the partition function in the anharmonic parameters we have been able to calculate the density of states for a model molecule composed by anharmonically coupled anharmonic oscillators, which cannot be treated by the well known Beyer-Swinehart algorithm.
NASA Astrophysics Data System (ADS)
Noh, Seunghyo; Kwak, Dohyun; Lee, Juseung; Kang, Joonhee; Han, Byungchan
2014-03-01
We utilized first-principles density-functional-theory (DFT) calculations to evaluate the thermodynamic feasibility of a pyroprocessing methodology for reducing the volume of high-level radioactive materials and recycling spent nuclear fuels. The thermodynamic properties of transuranium elements (Pu, Np and Cm) were obtained in electrochemical equilibrium with a LiCl-KCl molten salt as ionic phases and as adsorbates on a W(110) surface. To accomplish the goal, we rigorously calculated the double layer interface structures on an atomic resolution, on the thermodynamically most stable configurations on W(110) surfaces and the chemical activities of the transuranium elements for various coverages of those elements. Our results indicated that the electrodeposition process was very sensitive to the atomic level structures of Cl ions at the double-layer interface. Our studies are easily expandable to general electrochemical applications involving strong redox reactions of transition metals in non-aqueous solutions.
Guerin, P.; Baudron, A. M.; Lautard, J. J.
2006-07-01
This paper describes a new technique for determining the pin power in heterogeneous core calculations. It is based on a domain decomposition with overlapping sub-domains and a component mode synthesis technique for the global flux determination. Local basis functions are used to span a discrete space that allows fundamental global mode approximation through a Galerkin technique. Two approaches are given to obtain these local basis functions: in the first one (Component Mode Synthesis method), the first few spatial eigenfunctions are computed on each sub-domain, using periodic boundary conditions. In the second one (Factorized Component Mode Synthesis method), only the fundamental mode is computed, and we use a factorization principle for the flux in order to replace the higher order Eigenmodes. These different local spatial functions are extended to the global domain by defining them as zero outside the sub-domain. These methods are well-fitted for heterogeneous core calculations because the spatial interface modes are taken into account in the domain decomposition. Although these methods could be applied to higher order angular approximations - particularly easily to a SPN approximation - the numerical results we provide are obtained using a diffusion model. We show the methods' accuracy for reactor cores loaded with UOX and MOX assemblies, for which standard reconstruction techniques are known to perform poorly. Furthermore, we show that our methods are highly and easily parallelizable. (authors)
NASA Astrophysics Data System (ADS)
Tchitchekova, Deyana S.; Morthomas, Julien; Ribeiro, Fabienne; Ducher, Roland; Perez, Michel
2014-07-01
A novel method for accurate and efficient evaluation of the change in energy barriers for carbon diffusion in ferrite under heterogeneous stress is introduced. This method, called Linear Combination of Stress States, is based on the knowledge of the effects of simple stresses (uniaxial or shear) on these diffusion barriers. Then, it is assumed that the change in energy barriers under a complex stress can be expressed as a linear combination of these already known simple stress effects. The modifications of energy barriers by either uniaxial traction/compression and shear stress are determined by means of atomistic simulations with the Climbing Image-Nudge Elastic Band method and are stored as a set of functions. The results of this method are compared to the predictions of anisotropic elasticity theory. It is shown that, linear anisotropic elasticity fails to predict the correct energy barrier variation with stress (especially with shear stress) whereas the proposed method provides correct energy barrier variation for stresses up to ˜3 GPa. This study provides a basis for the development of multiscale models of diffusion under non-uniform stress.
Tchitchekova, Deyana S; Morthomas, Julien; Ribeiro, Fabienne; Ducher, Roland; Perez, Michel
2014-07-21
A novel method for accurate and efficient evaluation of the change in energy barriers for carbon diffusion in ferrite under heterogeneous stress is introduced. This method, called Linear Combination of Stress States, is based on the knowledge of the effects of simple stresses (uniaxial or shear) on these diffusion barriers. Then, it is assumed that the change in energy barriers under a complex stress can be expressed as a linear combination of these already known simple stress effects. The modifications of energy barriers by either uniaxial traction/compression and shear stress are determined by means of atomistic simulations with the Climbing Image-Nudge Elastic Band method and are stored as a set of functions. The results of this method are compared to the predictions of anisotropic elasticity theory. It is shown that, linear anisotropic elasticity fails to predict the correct energy barrier variation with stress (especially with shear stress) whereas the proposed method provides correct energy barrier variation for stresses up to ∼3 GPa. This study provides a basis for the development of multiscale models of diffusion under non-uniform stress.
Tchitchekova, Deyana S.; Morthomas, Julien; Perez, Michel; Ribeiro, Fabienne; Ducher, Roland
2014-07-21
A novel method for accurate and efficient evaluation of the change in energy barriers for carbon diffusion in ferrite under heterogeneous stress is introduced. This method, called Linear Combination of Stress States, is based on the knowledge of the effects of simple stresses (uniaxial or shear) on these diffusion barriers. Then, it is assumed that the change in energy barriers under a complex stress can be expressed as a linear combination of these already known simple stress effects. The modifications of energy barriers by either uniaxial traction/compression and shear stress are determined by means of atomistic simulations with the Climbing Image-Nudge Elastic Band method and are stored as a set of functions. The results of this method are compared to the predictions of anisotropic elasticity theory. It is shown that, linear anisotropic elasticity fails to predict the correct energy barrier variation with stress (especially with shear stress) whereas the proposed method provides correct energy barrier variation for stresses up to ∼3 GPa. This study provides a basis for the development of multiscale models of diffusion under non-uniform stress.
Strong, Randy; Miller, Richard A; Astle, Clinton M; Baur, Joseph A; de Cabo, Rafael; Fernandez, Elizabeth; Guo, Wen; Javors, Martin; Kirkland, James L; Nelson, James F; Sinclair, David A; Teter, Bruce; Williams, David; Zaveri, Nurulain; Nadon, Nancy L; Harrison, David E
2013-01-01
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.
A T-matrix calculation for in-medium heavy-quark gluon scattering
NASA Astrophysics Data System (ADS)
Huggins, K.; Rapp, R.
2012-12-01
The interactions of charm and bottom quarks in a quark-gluon plasma (QGP) are evaluated using a thermodynamic 2-body T-matrix. We specifically focus on heavy-quark (HQ) interactions with thermal gluons with an input potential motivated by lattice-QCD computations of the HQ free energy. The latter is implemented into a field-theoretic ansatz for color-Coulomb and (remnants of) confining interactions. This, in particular, enables to discuss corrections to the potential approach, specifically hard-thermal-loop corrections to the vertices, relativistic corrections deduced from pertinent Feynman diagrams, and a suitable projection on transverse thermal gluons. The resulting potentials are applied to compute scattering amplitudes in different color channels and utilized for a calculation of the corresponding HQ drag coefficient in the QGP. A factor of ˜2-3 enhancement over perturbative results is obtained, mainly driven by the resummation in the attractive color-channels.
Calculation of motion of a spherical drop in the Bingham medium
NASA Astrophysics Data System (ADS)
Pivovarov, Yu. V.
2012-07-01
Mathematical modeling of the experimentally observed process of approaching of two identical oil drops located in an alcohol-water solution (matrix) with an identical density is performed. It is found that the drop moves in cycles consisting of the state at rest, acceleration, and deceleration; the cycle time is about 10-2 s. Violation of the balance of forces on the drop boundary in the state at rest is caused by the fact that the shear stresses on this boundary cannot exceed the yield stress of the matrix, and the normal stresses are determined by solving the problem of the elasticity theory, because intermolecular bonds in the quiescent matrix make it similar to a solid. The results of drop motion calculations and experimental data agree well during the entire process of drop approaching, except for the final stage, which can be attributed to the neglect of hydrodynamic interaction of the drops.
Barth, G.R.; Hill, M.C.; Illangasekare, T.H.; Rajaram, H.
2001-01-01
As a first step toward understanding the role of sedimentary structures in flow and transport through porous media, this work deterministically examines how small-scale laboratory-measured values of hydraulic conductivity relate to in situ values of simple, artificial structures in an intermediate-scale (10 m long), two-dimensional, heterogeneous, laboratory experiment. Results were judged based on how well simulations using measured values of hydraulic conductivities matched measured hydraulic heads, net flow, and transport through the tank. Discrepancies were investigated using sensitivity analysis and nonlinear regression estimates of the in situ hydraulic conductivity that produce the best fit to measured hydraulic heads and net flow. Permeameter and column experiments produced laboratory measurements of hydraulic conductivity for each of the sands used in the intermediate-scale experiments. Despite explicit numerical representation of the heterogeneity the laboratory-measured values underestimated net flow by 12-14% and were distinctly smaller than the regression-estimated values. The significance of differences in measured hydraulic conductivity values was investigated by comparing variability of transport predictions using the different measurement methods to that produced by different realizations of the heterogeneous distribution. Results indicate that the variations in measured hydraulic conductivity were more important to transport than variations between realizations of the heterogeneous distribution of hydraulic conductivity.
Choi, Sunghwan; Kwon, Oh-Kyoung; Kim, Jaewook; Kim, Woo Youn
2016-09-15
We investigated the performance of heterogeneous computing with graphics processing units (GPUs) and many integrated core (MIC) with 20 CPU cores (20×CPU). As a practical example toward large scale electronic structure calculations using grid-based methods, we evaluated the Hartree potentials of silver nanoparticles with various sizes (3.1, 3.7, 4.9, 6.1, and 6.9 nm) via a direct integral method supported by the sinc basis set. The so-called work stealing scheduler was used for efficient heterogeneous computing via the balanced dynamic distribution of workloads between all processors on a given architecture without any prior information on their individual performances. 20×CPU + 1GPU was up to ∼1.5 and ∼3.1 times faster than 1GPU and 20×CPU, respectively. 20×CPU + 2GPU was ∼4.3 times faster than 20×CPU. The performance enhancement by CPU + MIC was considerably lower than expected because of the large initialization overhead of MIC, although its theoretical performance is similar with that of CPU + GPU. © 2016 Wiley Periodicals, Inc. PMID:27431905
Choi, Sunghwan; Kwon, Oh-Kyoung; Kim, Jaewook; Kim, Woo Youn
2016-09-15
We investigated the performance of heterogeneous computing with graphics processing units (GPUs) and many integrated core (MIC) with 20 CPU cores (20×CPU). As a practical example toward large scale electronic structure calculations using grid-based methods, we evaluated the Hartree potentials of silver nanoparticles with various sizes (3.1, 3.7, 4.9, 6.1, and 6.9 nm) via a direct integral method supported by the sinc basis set. The so-called work stealing scheduler was used for efficient heterogeneous computing via the balanced dynamic distribution of workloads between all processors on a given architecture without any prior information on their individual performances. 20×CPU + 1GPU was up to ∼1.5 and ∼3.1 times faster than 1GPU and 20×CPU, respectively. 20×CPU + 2GPU was ∼4.3 times faster than 20×CPU. The performance enhancement by CPU + MIC was considerably lower than expected because of the large initialization overhead of MIC, although its theoretical performance is similar with that of CPU + GPU. © 2016 Wiley Periodicals, Inc.
Efficient heterogeneous execution of Monte Carlo shielding calculations on a Beowulf cluster.
Dewar, David; Hulse, Paul; Cooper, Andrew; Smith, Nigel
2005-01-01
Recent work has been done in using a high-performance 'Beowulf' cluster computer system for the efficient distribution of Monte Carlo shielding calculations. This has enabled the rapid solution of complex shielding problems at low cost and with greater modularity and scalability than traditional platforms. The work has shown that a simple approach to distributing the workload is as efficient as using more traditional techniques such as PVM (Parallel Virtual Machine). In addition, when used in an operational setting this technique is fairer with the use of resources than traditional methods, in that it does not tie up a single computing resource but instead shares the capacity with other tasks. These developments in computing technology have enabled shielding problems to be solved that would have taken an unacceptably long time to run on traditional platforms. This paper discusses the BNFL Beowulf cluster and a number of tests that have recently been run to demonstrate the efficiency of the asynchronous technique in running the MCBEND program. The BNFL Beowulf currently consists of 84 standard PCs running RedHat Linux. Current performance of the machine has been estimated to be between 40 and 100 Gflop s(-1). When the whole system is employed on one problem up to four million particles can be tracked per second. There are plans to review its size in line with future business needs.
NASA Astrophysics Data System (ADS)
Lauridsen, Bente; Hedemann Jensen, Per
1987-03-01
The basic dosimetric quantity in ICRP-publication no. 30 is the aborbed fraction AF( T←S). This parameter is the fraction of energy absorbed in a target organ T per emission of radiation from activity deposited in the source organ S. Based upon this fraction it is possible to calculate the Specific Effective Energy SEE( T← S). From this, the committed effective dose equivalent from an intake of radioactive material can be found, and thus the annual limit of intake for given radionuclides can be determined. A male phantom has been constructed with the aim of measuring the Specific Effective Energy SEE(T←S) in various target organs. Impressions-of real human organs have been used to produce vacuum forms. Tissue equivalent plastic sheets were sucked into the vacuum forms producing a shell with a shape identical to the original organ. Each organ has been made of two shells. The same procedure has been used for the body. Thin tubes through the organs make it possible to place TL dose meters in a matrix so the dose distribution can be measured. The phantom has been supplied with lungs, liver, kidneys, spleen, stomach, bladder, pancreas, and thyroid gland. To select a suitable body liquid for the phantom, laboratory experiments have been made with different liquids and different radionuclides. In these experiments the change in dose rate due to changes in density and composition of the liquid was determined. Preliminary results of the experiments are presented.
Budowle, Bruce; Baechtel, F Samuel; Chakraborty, Ranajit
2009-01-01
Offender DNA databases have been highly successful tools for generating investigative leads. Due to their success, the database sizes have increased such that some have suggested using the DNA profiles in offender databases for empirical pairwise studies to provide inferences regarding the validity of the current practices for generating random match probability estimates. These critics use observations under the assumption of independence to suggest that the current forensic DNA statistical calculations are invalid. However, some of these databases, such as CODIS, are not appropriate for such studies because they contain duplicate profiles and profiles of close relatives and are highly heterogeneous (i.e., comprised of individuals from many different population groups with unknown proportions). Observed departures from expectations will occur using these databases, but would have no relevance for questioning the reliability of statistical practices because the very heterogeneous data sets would be expected to violate the basic assumptions of independence. In addition, 9-, 10-, 11-, and 12-locus (out of 13 loci) matching profiles have been observed, are expected, and do not call into question the reliability of statistical practices. The phenomenon of matching profiles is similar to the concept of the birthday scenario. Regardless, simple computations under the assumption of independence for guideline purposes only show that partial matches observed in offender databases are not inconsistent with expectations. Indeed, computed random match probabilities that explain the observed matching profiles from pairwise comparisons are smaller than those observed based on routine casework calculations. Data analyses from offender databases based on assumptions of independence do not provide any basis for questioning the legitimacy of computations of random match probability values of any specific target profile based on the modified product rule that are currently followed
Vasco, D.W.
2011-10-01
Using an asymptotic technique, valid when the medium properties are smoothly-varying, I derive a semi-analytic expression for the propagation velocity of a quasi-static disturbance traveling within a nonlinear-elastic porous medium. The phase, a function related to the propagation time, depends upon the properties of the medium, including the pressure-sensitivities of the medium parameters, and on pressure and displacement amplitude changes. Thus, the propagation velocity of a disturbance depends upon its amplitude, as might be expected for a nonlinear process. As a check, the expression for the phase function is evaluated for a poroelastic medium, when the material properties do not depend upon the fluid pressure. In that case, the travel time estimates agree with conventional analytic estimates, and with values calculated using a numerical simulator. For a medium with pressure-dependent permeability I find general agreement between the semi-analytic estimates and estimates from a numerical simulation. In this case the pressure amplitude changes are obtained from the numerical simulator.
Carrasco, P.; Jornet, N.; Duch, M.A.; Weber, L.; Ginjaume, M.; Eudaldo, T.; Jurado, D.; Ruiz, A.; Ribas, M.
2004-10-01
An extensive set of benchmark measurement of PDDs and beam profiles was performed in a heterogeneous layer phantom, including a lung equivalent heterogeneity, by means of several detectors and compared against the predicted dose values by different calculation algorithms in two treatment planning systems. PDDs were measured with TLDs, plane parallel and cylindrical ionization chambers and beam profiles with films. Additionally, Monte Carlo simulations by meansof the PENELOPE code were performed. Four different field sizes (10x10, 5x5, 2x2, and1x1 cm{sup 2}) and two lung equivalent materials (CIRS, {rho}{sub e}{sup w}=0.195 and St. Bartholomew Hospital, London, {rho}{sub e}{sup w}=0.244-0.322) were studied. The performance of four correction-based algorithms and one based on convolution-superposition was analyzed. The correction-based algorithms were the Batho, the Modified Batho, and the Equivalent TAR implemented in the Cadplan (Varian) treatment planning system and the TMS Pencil Beam from the Helax-TMS (Nucletron) treatment planning system. The convolution-superposition algorithm was the Collapsed Cone implemented in the Helax-TMS. The only studied calculation methods that correlated successfully with the measured values with a 2% average inside all media were the Collapsed Cone and the Monte Carlo simulation. The biggest difference between the predicted and the delivered dose in the beam axis was found for the EqTAR algorithm inside the CIRS lung equivalent material in a 2x2 cm{sup 2} 18 MV x-ray beam. In these conditions, average and maximum difference against the TLD measurements were 32% and 39%, respectively. In the water equivalent part of the phantom every algorithm correctly predicted the dose (within 2%) everywhere except very close to the interfaces where differences up to 24% were found for 2x2 cm{sup 2} 18 MV photon beams. Consistent values were found between the reference detector (ionization chamber in water and TLD in lung) and Monte Carlo
Brizuela, Alicia Beatriz; Castillo, María Victoria; Raschi, Ana Beatriz; Davies, Lilian; Romano, Elida; Brandán, Silvia Antonia
2014-03-31
In the present study, a complete assignment of the vibrational spectra of sucrose in aqueous medium was performed combining Pulay's Scaled Quantum Mechanics Force Field (SQMFF) methodology with self-consistent reaction field (SCRF) calculations. Aqueous saturated solutions of sucrose and solutions at different molar concentrations of sucrose in water were completely characterized by infrared, HATR, and Raman spectroscopies. In accordance with reported data of the literature for sucrose, the theoretical structures of sucrose penta and sucrose dihydrate were also optimized in gas and aqueous solution phases by using the density functional theory (DFT) calculations. The solvent effects for the three studied species were analyzed using the solvation PCM/SMD model and, then, their corresponding solvation energies were predicted. The presence of pure water, sucrose penta-hydrate, and sucrose dihydrate was confirmed by using theoretical calculations based on the hybrid B3LYP/6-31G(∗) method and the experimental vibrational spectra. The existence of both sucrose hydrate complexes in aqueous solution is evidenced in the IR and HATR spectra by means of the characteristic bands at 3388, 3337, 3132, 1648, 1375, 1241, 1163, 1141, 1001, 870, 851, 732, and 668cm(-1) while in the Raman spectrum, the groups of bands in the regions 3159-3053cm(-1), 2980, 2954, and 1749-1496cm(-1) characterize the vibration modes of those complexes. The inter and intra-molecular H bond formations in aqueous solution were studied by Natural Bond Orbital (NBO) and Atoms in Molecules theory (AIM) investigation. PMID:24632216
NASA Astrophysics Data System (ADS)
Cattania, C.; Khalid, F.
2016-09-01
The estimation of space and time-dependent earthquake probabilities, including aftershock sequences, has received increased attention in recent years, and Operational Earthquake Forecasting systems are currently being implemented in various countries. Physics based earthquake forecasting models compute time dependent earthquake rates based on Coulomb stress changes, coupled with seismicity evolution laws derived from rate-state friction. While early implementations of such models typically performed poorly compared to statistical models, recent studies indicate that significant performance improvements can be achieved by considering the spatial heterogeneity of the stress field and secondary sources of stress. However, the major drawback of these methods is a rapid increase in computational costs. Here we present a code to calculate seismicity induced by time dependent stress changes. An important feature of the code is the possibility to include aleatoric uncertainties due to the existence of multiple receiver faults and to the finite grid size, as well as epistemic uncertainties due to the choice of input slip model. To compensate for the growth in computational requirements, we have parallelized the code for shared memory systems (using OpenMP) and distributed memory systems (using MPI). Performance tests indicate that these parallelization strategies lead to a significant speedup for problems with different degrees of complexity, ranging from those which can be solved on standard multicore desktop computers, to those requiring a small cluster, to a large simulation that can be run using up to 1500 cores.
Hornberger, George M.; Mills, Aaron L.; Herman, Janet S.
2001-04-01
Among the demonstrated processes influencing the transport of bacteria through aquifers, the deposition of cells on mineral surfaces is one of the most important. Heterogeneous distribution of aquifer properties such as mineral-grain oxide coatings and preferred flow paths can control the numbers of microbes arriving a point down gradient from their injection, and these properties can also affect the distribution of the organisms remaining in the sedimentary matrix. The distribution of metal oxide coatings affects the final location of retained cells within the matrix but had no effect on total breakthrough of applied bacteria. We were able to demonstrate transverse mixing of both conservative tracers and bacteria between regions of differing hydraulic conductivity; the conservative tracer could be used to model the transverse mixing of the bacteria. We were able to show that the presence of metal oxide coatings on aquifer surfaces retarded a reactive tracer (SO{sub 4}{sup 2-}) that simulated bacterial retardation in the laboratory. When metal oxide coatings were absent (due to bacterial establishment of a reducing environment) the tracer and bacteria were not retarded. The effect was reproduced in a tracer experiment done in the field. The results suggest that bacterial transport in the subsurface is controlled by a number of interrelated and confounding factors that prevent accurate prediction of transport given the present state of knowledge.
Ganjehi, Lili; Marchiano, Régis; Coulouvrat, François; Thomas, Jean-Louis
2008-07-01
The influence of the planetary boundary layer on the sonic boom received at the ground level is known since the 1960s to be of major importance. Sonic boom propagation in a turbulent medium is characterized by an increase of the mean rise time and a huge variability. An experiment is conducted at a 1:100,000 scale in water to investigate ultrasonic shock wave interaction with a single heterogeneity. The experiment shows a very good scaling with sonic boom, concerning the size of the heterogeneities, the wave amplitude, and the rise time of the incident wave. The wave front folding associated with local focusing, and its link to the increase of the rise time, are evidenced by the experiment. The observed amplification of the peak pressure (by a factor up to 2), and increase of the rise time (by up to about one magnitude order), are in qualitative agreement with sonic boom observations. A nonlinear parabolic model is compared favorably to the experiment on axis, though the paraxial approximation turns out less precise off axis. Simulations are finally used to discriminate between nonlinear and linear propagations, showing nonlinearities affect mostly the higher harmonics that are in the audible range for sonic booms. PMID:18646955
Wang, Wei; Ma, Xuebing; Wan, Jingwei; Cao, Jun; Tang, Qian
2012-05-14
A series of novel porous zirconium phosphonate-supported 9-amino-9-deoxy-epi-cinchonidines of general formulae Zr(OH)(4-2x)(O(3)PR)(x)·nH(2)O and Zr(HPO(4))(2-x)(O(3)PR)(x)·nH(2)O with the different arm chain lengths (n = 2-6) and mean diameters of approximately 20-40 nm have been prepared as heterogeneous organocatalysts. The different microtextures of zirconium phosphonates were also obtained by using template guest molecules, such as Et(3)N, NaH(2)PO(4) and sodium dodecyl benzene sulfonate. In the heterogeneous asymmetric aldol addition of p-nitrobenzaldehyde to cyclohexanone, excellent catalytic properties were achieved, especially in an aqueous medium. After completing the reaction, those zirconium phosphonate-supported 9-amino-9-deoxy-epi-cinchonidine organocatalysts could be readily recovered in quantitative yield by centrifugation or filtration, and reused for five consecutive runs without significant loss in catalytic performance. In particular, due to the steric confinement effect of the inorganic backbone, the single different configuration among possible four stereo-isomers in aldol adducts were favorably obtained, respectively depending on the interaction between the o-, m- or p-position of nitrobenzaldehyde and the backbone, which was never observed in homogeneous aldol addition.
NASA Astrophysics Data System (ADS)
Berginc, G.
2016-08-01
In this paper, we consider the coherent component of the electromagnetic wave field inside random media. The subject of our interest concerns a random medium, consisting of a statistical ensemble of different scattering species and artificial material structures developed on base of dielectric or metallic resonant or non-resonant particles. The starting point of our theory is the multiple scattering theory, the averaged electric field satisfies a Dyson equation with a mass operator related to the effective dielectric permittivity of the homogenized structure. Quantum multiple scattering theory has been transposed into this electromagnetic case. We give a formal solution for the mass operator by introducing the T-matrix formalism. We show that the T-matrix satisfies a Lippman-Schwinger equation. Then, we introduce the Quasi-Crystalline Coherent Potential Approximation (QC-CPA), which takes into account the correlation between the particles with a pair-distribution function. The mass operator includes geometric effects, caused by resonant behavior due to the shape and size of particles, cluster effects because of correlations between particles. Significant modifications of particle scattering properties can be observed.
Moignier, C; Huet, C; Barraux, V; Loiseau, C; Sebe-Mercier, K; Batalla, A; Makovicka, L
2014-06-15
Purpose: Advanced stereotactic radiotherapy (SRT) treatments require accurate dose calculation for treatment planning especially for treatment sites involving heterogeneous patient anatomy. The purpose of this study was to evaluate the accuracy of dose calculation algorithms, Raytracing and Monte Carlo (MC), implemented in the MultiPlan treatment planning system (TPS) in presence of heterogeneities. Methods: First, the LINAC of a CyberKnife radiotherapy facility was modeled with the PENELOPE MC code. A protocol for the measurement of dose distributions with EBT3 films was established and validated thanks to comparison between experimental dose distributions and calculated dose distributions obtained with MultiPlan Raytracing and MC algorithms as well as with the PENELOPE MC model for treatments planned with the homogenous Easycube phantom. Finally, bones and lungs inserts were used to set up a heterogeneous Easycube phantom. Treatment plans with the 10, 7.5 or the 5 mm field sizes were generated in Multiplan TPS with different tumor localizations (in the lung and at the lung/bone/soft tissue interface). Experimental dose distributions were compared to the PENELOPE MC and Multiplan calculations using the gamma index method. Results: Regarding the experiment in the homogenous phantom, 100% of the points passed for the 3%/3mm tolerance criteria. These criteria include the global error of the method (CT-scan resolution, EBT3 dosimetry, LINAC positionning …), and were used afterwards to estimate the accuracy of the MultiPlan algorithms in heterogeneous media. Comparison of the dose distributions obtained in the heterogeneous phantom is in progress. Conclusion: This work has led to the development of numerical and experimental dosimetric tools for small beam dosimetry. Raytracing and MC algorithms implemented in MultiPlan TPS were evaluated in heterogeneous media.
Bolton, E.W.; Lasaga, A.C.; Rye, D.M.
1999-01-01
The kinetics of dissolution and precipitation is of central importance to understanding the long-term evolution of fluid flows in crustal environments, with implications for problems as diverse as nuclear waste disposal and crustal evolution. The authors examine the dynamics of such evolution for several geologically relevant permeability distributions (models for en-echelon cracks, an isolated sloping fractured zone, and two sloping high-permeability zones that are close enough together to interact). Although the focus is on a simple quartz matrix system, generic features emerge from this study that can aid in the broader goal of understanding the long-term feedback between flow and chemistry, where dissolution and precipitation is under kinetic control. Examples of thermal convection in a porous medium with spatially variable permeability reveal features of central importance to water-rock interaction. After a transient phase, an accelerated rate of change of porosity may be used with care to decrease computational time, as an alternative to the quasi-stationary state approximation (Lichtner, 1988). Kinetic effects produce features not expected by traditional assumptions made on the basis of equilibrium, for example, that cooling fluids are oversaturated and heating fluids are undersaturated with respect to silicic acid equilibrium. Indeed, the authors observe regions of downwelling oversaturated fluid experiencing heating and regions of upwelling, yet cooling, undersaturated fluid. When oscillatory convection is present, the amplitudes of oscillation generally increase with time in near-surface environments, whereas amplitudes tend to decrease over long times near the heated lower boundary. The authors examine the scaling behavior of characteristic length scales, of terms in the solute equation, and of the typical deviation from equilibrium, each as a function of the kinetic rate parameters.
NASA Astrophysics Data System (ADS)
Zhang, Y.; Chen, W.; Li, J.
2013-12-01
Climate change may alter the spatial distribution, composition, structure, and functions of plant communities. Transitional zones between biomes, or ecotones, are particularly sensitive to climate change. Ecotones are usually heterogeneous with sparse trees. The dynamics of ecotones are mainly determined by the growth and competition of individual plants in the communities. Therefore it is necessary to calculate solar radiation absorbed by individual plants for understanding and predicting their responses to climate change. In this study, we developed an individual plant radiation model, IPR (version 1.0), to calculate solar radiation absorbed by individual plants in sparse heterogeneous woody plant communities. The model is developed based on geometrical optical relationships assuming crowns of woody plants are rectangular boxes with uniform leaf area density. The model calculates the fractions of sunlit and shaded leaf classes and the solar radiation absorbed by each class, including direct radiation from the sun, diffuse radiation from the sky, and scattered radiation from the plant community. The solar radiation received on the ground is also calculated. We tested the model by comparing with the analytical solutions of random distributions of plants. The tests show that the model results are very close to the averages of the random distributions. This model is efficient in computation, and is suitable for ecological models to simulate long-term transient responses of plant communities to climate change.
NASA Technical Reports Server (NTRS)
Armstrong, T. W.; Bishop, B. L.
1972-01-01
Monte Carlo calculations have been carried out to determine the absorbed dose and dose equivalent for 592-MeV protons incident on a cylindrical phantom and for neutrons from 580-MeV proton-Be collisions incident on a semi-infinite phantom. For both configurations, the calculated depth dependence of the absorbed dose is in good agreement with experimental data.
NASA Astrophysics Data System (ADS)
Perez, F.; Mügler, C.; Jean-Baptiste, P.; Charlou, J. L.
2012-04-01
Hydrothermal activity at the axis of mid-ocean ridges is a key driver for energy and matter transfer from the interior of the Earth to the ocean floor. At mid-ocean ridges, seawater penetrates through the permeable young crust, warms at depth and exchanges chemicals with the surrounding rocks. This hot fluid focuses and flows upwards, then is expelled from the crust at hydrothermal vent sites in the form of black or white smokers completed by diffusive emissions. We developed a new numerical tool in the Cast3M software framework to model such hydrothermal circulations. Thermodynamic properties of one-phase pure water were calculated from the IAPWS formulation. This new numerical tool was validated on several test cases of convection in closed-top and open-top boxes. Simulations of hydrothermal circulation in a homogeneous-permeability porous medium also gave results in good agreement with already published simulations. We used this new numerical tool to construct a geometric and physical model configuration of the Rainbow Vent site at 36°14'N on the Mid-Atlantic Ridge. In this presentation, several configurations will be discussed, showing that high temperatures and high mass fluxes measured at the Rainbow site cannot be modelled with hydrothermal circulation in a homogeneous-permeability porous medium. We will show that these high values require the presence of a fault or a preferential pathway right below the venting site. We will propose and discuss a 2-D one-path model that allows us to simulate both high temperatures and high mass fluxes. This modelling of the hydrothermal circulation at the Rainbow site constitutes a first but necessary step to understand the origin of high concentrations of hydrogen issued from this ultramafic-hosted vent field.
Gibson, N. A.; Forget, B.
2012-07-01
The Discrete Generalized Multigroup (DGM) method uses discrete Legendre orthogonal polynomials to expand the energy dependence of the multigroup neutron transport equation. This allows a solution on a fine energy mesh to be approximated for a cost comparable to a solution on a coarse energy mesh. The DGM method is applied to an ultra-fine energy mesh (14,767 groups) to avoid using self-shielding methodologies without introducing the cost usually associated with such energy discretization. Results show DGM to converge to the reference ultra-fine solution after a small number of recondensation steps for multiple infinite medium compositions. (authors)
Betzler, Benjamin R.; Kiedrowski, Brian C.; Brown, Forrest B.; Martin, William R.
2015-01-01
The time-dependent behavior of the energy spectrum in neutron transport was investigated with a formulation, based on continuous-time Markov processes, for computing α eigenvalues and eigenvectors in an infinite medium. In this study, a research Monte Carlo code called “TORTE” (To Obtain Real Time Eigenvalues) was created and used to estimate elements of a transition rate matrix. TORTE is capable of using both multigroup and continuous-energy nuclear data, and verification was performed. Eigenvalue spectra for infinite homogeneous mixtures were obtained, and an eigenfunction expansion was used to investigate transient behavior of the neutron energy spectrum.
Li Jun; Galvin, James; Harrison, Amy; Timmerman, Robert; Yu Yan; Xiao Ying
2012-10-01
Purpose: The recently activated Radiation Therapy Oncology Group (RTOG) studies of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) require tissue density heterogeneity correction, where the high and intermediate dose compliance criteria were established based on superposition algorithm dose calculations. The study was aimed at comparing superposition algorithm dose calculations with Monte Carlo (MC) dose calculations for SBRT for NSCLC and to evaluate whether compliance criteria need to be adjusted for MC dose calculations. Methods and Materials: Fifteen RTOG 0236 study sets were used. The planning tumor volumes (PTV) ranged from 10.7 to 117.1 cm{sup 3}. SBRT conformal treatment plans were generated using XiO (CMS Inc.) treatment planning software with superposition algorithm to meet the dosimetric high and intermediate compliance criteria recommended by the RTOG 0813 protocol. Plans were recalculated using the MC algorithm of a Monaco (CMS, Inc.) treatment planning system. Tissue density heterogeneity correction was applied in both calculations. Results: Overall, the dosimetric quantities of the MC calculations have larger magnitudes than those of the superposition calculations. On average, R{sub 100%} (ratio of prescription isodose volume to PTV), R{sub 50%} (ratio of 50% prescription isodose volume to PTV), D{sub 2cm} (maximal dose 2 cm from PTV in any direction as a percentage of prescription dose), and V{sub 20} (percentage of lung receiving dose equal to or larger than 20 Gy) increased by 9%, 12%, 7%, and 18%, respectively. In the superposition plans, 3 cases did not meet criteria for R{sub 50%} or D{sub 2cm}. In the MC-recalculated plans, 8 cases did not meet criteria for R{sub 100%}, R{sub 50%}, or D{sub 2cm}. After reoptimization with MC calculations, 5 cases did not meet the criteria for R{sub 50%} or D{sub 2cm}. Conclusions: Results indicate that the dosimetric criteria, e.g., the criteria for R{sub 50%} recommended by
Folman, M.; Fastow, M.; Kozirovski, Y.
1997-03-05
In our recent investigation of the IR spectrum of CO physically adsorbed on C{sub 60} films, two well-resolved absorption bands at 2135 and 2128 cm{sup -1} were found, suggesting that the molecule is adsorbed on two different sites. To determine the nature of these adsorption sites, calculations of adsorption potentials and spectral shifts for the CO/C{sub 60} system were performed. The calculations were done for the fcc (100), fcc (111) hcp (001), and hcp (111) surface planes. In the calculations the 6-exponential and the Lennard-Jones potentials were used. A number of adsorption sites were chosen. These included the void space between four, three, and two neighboring C{sub 60} molecules and the center of the hexagon and the pentagon on the C{sub 60} surface. The calculated potentials and spectral shifts clearly indicate that adsorption sites in the voids between the C{sub 60} molecules are energetically preferred over sites on top of single C{sub 60} molecules. Comparison is made between results obtained with the two potentials and with results obtained previously with the two other carbon allotropes: graphite and diamond. 11 refs., 4 figs., 3 tabs.
NASA Astrophysics Data System (ADS)
Sörgel, M.; Trebs, I.; Wu, D.; Held, A.
2015-08-01
Vertical mixing ratio profiles of nitrous acid (HONO) were measured in a clearing and on the forest floor in a rural forest environment. For the forest floor, HONO was found to predominantly deposit, whereas for the clearing, net deposition dominated only during nighttime and net emissions were observed during daytime. For selected days, net fluxes of HONO were calculated from the measured profiles using the aerodynamic gradient method. The emission fluxes were in the range of 0.02 to 0.07 nmol m-2 s-1 and thus were in the lower range of previous observations. These fluxes were compared to the strengths of postulated HONO sources. Laboratory measurements of different soil samples from both sites revealed an upper limit for soil biogenic HONO emission fluxes of 0.025 nmol m-2 s-1. HONO formation by light-induced NO2 conversion was calculated to be below 0.03 nmol m-2 s-1 for the investigated days, which is comparable to the potential soil fluxes. Due to light saturation at low irradiance, this reaction pathway was largely found to be independent of light intensity, i.e. it was only dependent on ambient NO2. We used three different approaches based on measured leaf nitrate loadings for calculating HONO formation from HNO3 photolysis. While the first two approaches based on empirical HONO formation rates yielded values in the same order of magnitude as the estimated fluxes, the third approach based on available kinetic data of the postulated pathway failed to produce noticeable amounts of HONO. Estimates based on reported cross sections of adsorbed HNO3 indicate that the lifetime of adsorbed HNO3 was only about 15 min, which would imply a substantial renoxification. Although the photolysis of HNO3 was significantly enhanced at the surface, the subsequent light-induced conversion of the photolysis product NO2 did not produce considerable amounts of HONO. Consequently, this reaction might occur via an alternative mechanism. By explicitly calculating HONO formation based
Laberge, M; Köhler, M; Vanderkooi, J M; Friedrich, J
1999-01-01
We report on a comparative investigation of the heme pocket fields of two Zn-substituted c-type cytochromes-namely yeast and horse heart cytochromes c-using a combination of hole burning Stark spectroscopy and electrostatic calculations. The spectral hole burning experiments are consistent with different pocket fields experienced at the hemes of the respective cytochromes. In the case of horse heart Zn-cytochrome c, two distinguishable electronic origins with different electrostatic properties are observed. The yeast species, on the other hand, displays a single electronic origin. Electrostatic calculations and graphics modeling using the linearized finite-difference Poisson-Boltzmann equation performed at selected time intervals on nanosecond-molecular dynamics trajectories show that the hemes of the respective cytochromes sample different potentials as they explore conformational space. The electrostatic potentials generated by the protein matrix at the heme show different patterns in both cytochromes, and we suggest that the cytochromes differ by the number of "electrostatic substates" that they can sample, thus accounting for the different spectral populations observed in the two cytochromes. PMID:10585951
NASA Astrophysics Data System (ADS)
Potekaev, A. I.; Bubenchikov, A. M.; Bubenchikov, M. A.
2013-05-01
New ideas and a new approach to the motion of small-including nanosized-particles are presented, resting on basic concepts of the molecular kinetic theory of gases, statistical physics, and classical mechanics. Two new concepts are introduced: the λ-layer and "counter-moving" pairs of molecules. The first makes it possible to limit the number of molecules under consideration and ignore their collisions with each other. The second makes it possible to exclude Brownian motion of the molecules. It is established that the action of potential van der Waals forces is localized in the vicinity of the small particle in such a way that it is possible in the statistical calculations to assume that the trajectories of the molecules consist of line segments and that impact of a molecule is perfectly elastic and equivalent to impact on an "effective particle" with linear dimension 40% higher than the actual diameter of the particle. Good agreement is obtained with the experimental Cunningham-Millikan-Davies (CMD) approximation, and also with extrapolated values of this approximation.
1980-05-19
FANTOM calculates the response of a 20-cm-diameter phoswich (3 mm NaI(Tl) primary detector) to a source of low energy photons distributed in the lungs of a heterogeneous MIRD phantom, approximating ICRP Reference Man. The program considers the trunk region of the MIRD phantom which is made up of three types of tissues with different densities: skeletal tissue (1.85), lung tissue (0.3) and soft tissue (1). Each organ in the thorax region is described by simplemore » quadratic equations, with respect to a Cartesian coordinate system (X,Y,Z), the origin of which is located at the center of the base of the trunk, with positive Z-axis, Y-axis, and X-axis directed toward the head, posterior, and left side of the phantom, respectively.« less
NASA Astrophysics Data System (ADS)
Min, Y.; Yao, K. L.; Liu, Z. L.; Cheng, H. G.; Zhu, S. C.; Gao, G. Y.
2009-02-01
We report on first-principles calculations of spin-dependent quantum transport in a CrAs(0 0 1)/AlAs(0 0 1) heterogeneous junction and predict a strong diode effect of charge and spin current. The minority spin current is absolutely inhibited when the bias voltage is applied to the terminals of both CrAs and AlAs. The majority spin current is inhibited when the bias voltage is applied to the terminal of CrAs and "relaxed" when the bias voltage is applied to the terminal of AlAs. The charge and spin current diode are promising for reprogrammable logic applications in the field of spintronics.
NASA Astrophysics Data System (ADS)
Zhu, X. L.; Zeng, X. C.; Lei, Y. A.; Pan, B.
2004-05-01
Ab initio all-electron molecular-orbital calculations are carried out to study the structures and relative stability of low-energy silicon clusters (Sin,n=12-20). Selected geometric isomers include those predicted by Ho et al. [Nature (London) 392, 582 (1998)] based on an unbiased search with tight-binding/genetic algorithm, as well as those found by Rata et al. [Phys. Rev. Lett. 85, 546 (2000)] based on density-functional tight-binding/single-parent evolution algorithm. These geometric isomers are optimized at the Møller-Plesset (MP2) MP2/6-31G(d) level. The single-point energy at the coupled-cluster single and double substitutions (including triple excitations) [CCSD(T)] CCSD(T)/6-31G(d) level for several low-lying isomers are further computed. Harmonic vibrational frequency analysis at the MP2/6-31G(d) level of theory is also undertaken to assure that the optimized geometries are stable. For Si12-Si17 and Si19 the isomer with the lowest-energy at the CCSD(T)/6-31G(d) level is the same as that predicted by Ho et al., whereas for Si18 and Si20, the same as predicted by Rata et al. However, for Si14 and Si15, the vibrational frequency analysis indicates that the isomer with the lowest CCSD(T)/6-31G(d) single-point energy gives rise to imaginary frequencies. Small structural perturbation onto the Si14 and Si15 isomers can remove the imaginary frequencies and results in new isomers with slightly lower MP2/6-31G(d) energy; however the new isomers have a higher single-point energy at the CCSD(T)/6-31G(d) level. For most Sin (n=12-18,20) the low-lying isomers are prolate in shape, whereas for Si19 a spherical-like isomer is slightly lower in energy at the CCSD(T)/6-31G(d) level than low-lying prolate isomers.
Fukuda, Ryoichi; Ehara, Masahiro
2014-11-15
The efficiency and accuracy of the perturbation-selection used in the symmetry-adapted cluster-configuration interaction (SAC-CI) calculations are investigated for several low-lying valence excited states of 21 medium-size molecules, including typical chromophores with heterocyclic macrocycles (free-base porphine, coumarin, indole, and BODIPY), nucleobases, amino acids (tyrosine and tryptophan), polycyclic aromatic hydrocarbons, and organometallics (ferrocene and Re(bpy)(CO)4+1). Benchmark SAC-CI calculations with up to 110 million operators are performed. The efficiency of the perturbation-selection depends on the molecular orbitals (MOs); therefore, the canonical MO and localized MO (LMO) obtained by Pipek-Mezey's method are examined. Except for the highly symmetric molecules, using LMOs improves the efficiency and accuracy of the perturbation-selection. With using LMOs and perturbation-selection, sufficiently reliable results can be obtained in less than 10% of the computational costs required for the full-dimensional calculations. The perturbation-selection with LMOs is suggested to be a promising method for excited states in larger molecular systems.
NASA Astrophysics Data System (ADS)
Yan, Kun
2007-04-01
In this paper, by discussing the basic hypotheses about the continuous orbit and discrete orbit in two research directions of the background medium theory for celestial body motion, the concrete equation forms and their summary of the theoretic frame of celestial body motion are introduced. Future more, by discussing the general form of Binet's equation of celestial body motion orbit and it's solution of the advance of the perihelion of planets, the relations and differences between the continuous orbit theory and Newton's gravitation theory and Einstein's general relativity are given. And by discussing the fractional-dimension expanded equation for the celestial body motion orbits, the concrete equations and the prophesy data of discrete orbit or stable orbits of celestial bodies which included the planets in the Solar system, satellites in the Uranian system, satellites in the Earth system and satellites obtaining the Moon obtaining from discrete orbit theory are given too. Especially, as the preliminary exploration and inference to the gravitation curve of celestial bodies in broadly range, the concept for the ideal black hole with trend to infinite in mass density difficult to be formed by gravitation only is explored. By discussing the position hypothesis of fractional-dimension derivative about general function and the formula form the hypothesis of fractional-dimension derivative about power function, the concrete equation formulas of fractional-dimension derivative, differential and integral are described distinctly further, and the difference between the fractional-dimension derivative and the fractional-order derivative are given too. Subsequently, the concrete forms of measure calculation equations of self-similar fractal obtaining by based on the definition of form in fractional-dimension calculus about general fractal measure are discussed again, and the differences with Hausdorff measure method or the covering method at present are given. By applying
Kuppusamy, Vijayalakshmi; Nagarajan, Vivekanandan; Jeevanandam, Prakash; Murugan, Lavanya
2016-02-01
The study was aimed to compare two different monitor unit (MU) or dose verification software in volumetric modulated arc therapy (VMAT) using modified Clarkson's integration technique for 6 MV photons beams. In-house Excel Spreadsheet based monitor unit verification calculation (MUVC) program and PTW's DIAMOND secondary check software (SCS), version-6 were used as a secondary check to verify the monitor unit (MU) or dose calculated by treatment planning system (TPS). In this study 180 patients were grouped into 61 head and neck, 39 thorax and 80 pelvic sites. Verification plans are created using PTW OCTAVIUS-4D phantom and also measured using 729 detector chamber and array with isocentre as the suitable point of measurement for each field. In the analysis of 154 clinically approved VMAT plans with isocentre at a region above -350 HU, using heterogeneity corrections, In-house Spreadsheet based MUVC program and Diamond SCS showed good agreement TPS. The overall percentage average deviations for all sites were (-0.93% + 1.59%) and (1.37% + 2.72%) for In-house Excel Spreadsheet based MUVC program and Diamond SCS respectively. For 26 clinically approved VMAT plans with isocentre at a region below -350 HU showed higher variations for both In-house Spreadsheet based MUVC program and Diamond SCS. It can be concluded that for patient specific quality assurance (QA), the In-house Excel Spreadsheet based MUVC program and Diamond SCS can be used as a simple and fast accompanying to measurement based verification for plans with isocentre at a region above -350 HU.
NASA Astrophysics Data System (ADS)
Suzuki, W.; Aoi, S.; Maeda, T.; Sekiguchi, H.; Kunugi, T.
2013-12-01
Source inversion analysis using near-source strong-motion records with an assumption of 1-D underground structure models has revealed the overall characteristics of the rupture process of the 2011 Tohoku-Oki mega-thrust earthquake. This assumption for the structure model is acceptable because the seismic waves radiated during the Tohoku-Oki event were rich in the very-low-frequency contents lower than 0.05 Hz, which are less affected by the small-scale heterogeneous structure. The analysis using more reliable Green's functions even in the higher-frequency range considering complex structure of the subduction zone will illuminate more detailed rupture process in space and time and the transition of the frequency dependence of the wave radiation for the Tohoku-Oki earthquake. In this study, we calculate the near-source Green's functions using a 3-D underground structure model and perform the source inversion analysis using them. The 3-D underground structure model used in this study is the Japan Integrated Velocity Structure Model (Headquarters for Earthquake Research Promotion, 2012). A curved fault model on the Pacific plate interface is discretized into 287 subfaults at ~20 km interval. The Green's functions are calculated using GMS (Aoi et al., 2004), which is a simulation program package for the seismic wave field by the finite difference method using discontinuous grids (Aoi and Fujiwara, 1999). Computational region is 136-146.2E in longitude, 34-41.6N in latitude, and 0-100 km in depth. The horizontal and vertical grid intervals are 200 m and 100 m, respectively, for the shallower region and those for the deeper region are tripled. The number of the total grids is 2.1 billion. We derive 300-s records by calculating 36,000 steps with a time interval of 0.0083 second (120 Hz sampling). It takes nearly one hour to compute one case using 48 Graphics Processing Units (GPU) on TSUBAME2.0 supercomputer owned by Tokyo Institute of Technology. In total, 574 cases are
NASA Astrophysics Data System (ADS)
Lazarev, Y.; Petrov, P.; Tartakovsky, D. M.
2002-12-01
In this paper the problem of vacuum-incompressible fluid interface moving in a porous medium by treating conductivity of a medium as a random field with known statistics is considered. The flow is described by a combination of mass conservation and Darcy' law. The use of a coordinate system tied with the moving fluid allows reducing the problem to the well-explored class of problems with fixed boundaries and an effective conductivity tensor instead of the initial scalar conductivity. The hydraulic head is represented as a series in powers of effective conductivity fluctuations. The applied procedure is close to the perturbation theory procedure in the amplitude of the hydraulic conductivity fluctuations ˜ K when searching the solution with accuracy up to ˜ K2 . In both cases physical quantity variance is considered to be proportional to its reason: ˜ V = A ṡ ˜ K ( A is a linear operator). Yet unlike perturbation theory, where it is considered that A depends only on undisturbed flow parameters A = A(¯ K), in the approach being used A is considered to be dependent on averaged flow parameters A = A( ¯ K,< ˜ K2 > ). Equations of the mean hydraulic head and mean flux and expressions for respective variances as well are derived in the 2-D case. For 1-D flow the derived solution agrees with the exact one within terms of σ K2 -order at any free surface fluctuations. Within this approach the free surface moving, evolution in time of the mean hydraulic head spatial distribution, mean flux and relative correlation functions are described by the set of first-order partial differential equations. The conjugate gradient method with preconditioning is proposed to be used as the general method of equation numerical solving to find hydraulic head statistic moments. The problem matrix symmetry and its positive definiteness serve the foundation of the method applicability. RFLOW code has been elaborated to solve this set of equations numerically. Testing data of the
Leshchinskii, V.M.; Blokhin, A.G.; Stoyanov, A.A.
1995-01-01
We have studied the effect of the technological parameters on the molding process during shear compression of powder composites. An algorithm has been developed for the design of the technological processes. The correspondence between the continuum model of the uniform shear of a layer of powder and the actual behavior of the medium is analyzed and the physical sense of the compaction rate, which characterizes the sensitivity of the given medium to hydrostatic pressure, is determined.
NASA Astrophysics Data System (ADS)
Forbes Inskip, Nathaniel; Meredith, Philip; Gudmundsson, Agust
2016-04-01
While considerable effort has been expended on the study of fracture propagation in rocks in recent years, our understanding of how fractures propagate through layered sedimentary rocks with different mechanical and elastic properties remains poorly constrained. Yet this is a key issue controlling the propagation of both natural and anthropogenic hydraulic fractures in layered sequences. Here we report measurements of the contrasting mechanical and elastic properties of the Lower Lias at Nash Point, South Wales, which comprises an interbedded sequence of shale and limestone layers, and how those properties may influence fracture propagation. Elastic properties of both materials have been characterised via ultrasonic wave velocity measurements as a function of azimuth on samples cored both normal and parallel to bedding. The shale is highly anisotropic, with P-wave velocities varying from 2231 to 3890 m s-1, giving an anisotropy of ~55%. By contrast, the limestone is essentially isotropic, with a mean P-wave velocity of 5828 m s-1 and an anisotropy of ~2%. The dynamic Young's modulus of the shale, calculated from P- and S-wave velocity data, is also anisotropic with a value of 36 GPa parallel to bedding and 12 GPa normal to bedding. The modulus of the limestone is again isotropic with a value of 80 GPa. It follows that for a vertical fracture propagating (i.e. normal to bedding) the modulus contrast is 6.6. This is important because the contrast in elastic properties is a key factor in controlling whether fractures arrest, deflect, or propagate across interfaces between layers in a sequence. There are three principal mechanisms by which a fracture may deflect across or along an interface, namely: Cook-Gordon debonding, stress barrier, and elastic mismatch. Preliminary numerical modelling results (using a Finite Element Modelling software) of induced fractures at Nash Point suggest that all three are important. The results demonstrate a rotation of the maximum
ERIC Educational Resources Information Center
Shieh, Gwowen; Jan, Show-Li
2015-01-01
The general formulation of a linear combination of population means permits a wide range of research questions to be tested within the context of ANOVA. However, it has been stressed in many research areas that the homogeneous variances assumption is frequently violated. To accommodate the heterogeneity of variance structure, the…
Walker Diffusion Method for Calculation of Transport Properties of Finite Composite Systems
Van Siclen, Clinton D
2002-01-01
A heterogeneous medium may be represented by a scalar field of local transport coefficients (e.g., conductivity) or by a “resistor network” derived from that scalar field. In either case the effective (macroscopic) and local (microscopic) transport properties may be calculated by the walker diffusion method. Some sample calculations for disordered systems are presented to demonstrate the method.
Thermal properties of heterogeneous grains
NASA Technical Reports Server (NTRS)
Lien, David J.
1988-01-01
Cometary dust is not spherical nor homogeneous, yet these are the assumptions used to model its thermal, optical, and dynamical properties. To better understand the effects of heterogeneity on the thermal and optical properties of dust grains, the effective dielectric constant for an admixture of magnetite and a silicate were calculated using two different effective medium theories: the Maxwell-Garnett theory and the Bruggeman theory. In concept, the MG theory describes the effective dielectric constant of a matrix material into which is embedded a large number of very small inclusions of a second material. The Bruggeman theory describes the dielectric constant of a well mixed aggregate of two or more types of materials. Both theories assume that the individual particles are much smaller than the wavelength of the incident radiation. The refractivity for a heterogeneous grain using the MG theory is very similar to the refractivity of the matrix material, even for large volume fractions of the inclusion. The equilibrium grain temperature for spherical particles sized from .001 to 100 microns in radius at 1 astronomical unit from the sun was calculated. Further explanation is given.
NASA Astrophysics Data System (ADS)
Zhou, Huai-Chun; Cheng, Qiang; Huang, Zhi-Feng; He, Cheng
2007-03-01
Even though there have been many ways to treat complex anisotropic scattering problems, in most of the cases only the radiation flux or its dimensionless data were provided, and radiative intensity with high directional resolution could merely be seen. In this paper, a comprehensive formulation for the DRESOR method was proposed to deal with the anisotropic scattering, emitting, absorbing, plane-parallel media with different boundary conditions. The method was validated by the data from literature and the integral formulation of RTE. The DRESOR value plays an important role in the DRESOR method, and how it is determined by the anisotropic scattering was demonstrated by some typical results. The intensities with high directional resolution at any point can be given by the present method. It was found that the scattering phase function has little effect on the intensity for thin optical thickness, for example, 0.1. And there is the largest boundary intensity for the medium with the largest forward scattering capability, and the smallest one with the largest backward scattering capability. An attractive phenomenon was observed that the scattering of the medium makes the intensity at boundary can not reach the blackbody emission capability with the same temperature, even if the optical thickness tends to very large. It was also revealed that the scattering of the medium does not mean it cannot alter the magnitude of the energy; actually, stronger scattering causes the energy to have more chance to be absorbed by the medium, and indirectly changes the energy magnitude in the medium. Finally, it is easy to deduce all the associated quantities such as the radiation flux, the incident radiation and the heat source from the intensity, just as done in literature.
Optimization of permanent breast seed implant dosimetry incorporating tissue heterogeneity
NASA Astrophysics Data System (ADS)
Mashouf, Shahram
Seed brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose around brachytherapy sources is based on the AAPM TG43 formalism, which generates the dose in homogeneous water medium. Recently, AAPM task group no. 186 (TG186) emphasized the importance of accounting for heterogeneities. In this work we introduce an analytical dose calculation algorithm in heterogeneous media using CT images. The advantages over other methods are computational efficiency and the ease of integration into clinical use. An Inhomogeneity Correction Factor (ICF) is introduced as the ratio of absorbed dose in tissue to that in water medium. ICF is a function of tissue properties and independent of the source structure. The ICF is extracted using CT images and the absorbed dose in tissue can then be calculated by multiplying the dose as calculated by the TG43 formalism times ICF. To evaluate the methodology, we compared our results with Monte Carlo simulations as well as experiments in phantoms with known density and atomic compositions. The dose distributions obtained through applying ICF to TG43 protocol agreed very well with those of Monte Carlo simulations and experiments in all phantoms. In all cases, the mean relative error was reduced by at least a factor of two when ICF correction factor was applied to the TG43 protocol. In conclusion we have developed a new analytical dose calculation method, which enables personalized dose calculations in heterogeneous media using CT images. The methodology offers several advantages including the use of standard TG43 formalism, fast calculation time and extraction of the ICF parameters directly from Hounsfield Units. The methodology was implemented into our clinical treatment planning system where a cohort of 140 patients were processed to study the clinical benefits of a heterogeneity corrected dose.
Deng, Banglin; Jiang, Gang; Zhang, Chuanyu
2014-09-15
In this work, the multi-configuration Dirac–Fock and relativistic configuration-interaction methods have been used to calculate the transition wavelengths, electric dipole transition probabilities, line strengths, and absorption oscillator strengths for the 2s–3p, 2p–3s, and 2p–3d transitions in Li-like ions with nuclear charge Z=7–30. Our calculated values are in good agreement with previous experimental and theoretical results. We took the contributions from Breit interaction, finite nuclear mass corrections, and quantum electrodynamics corrections to the initial and final levels into account, and also found that the contributions from Breit interaction, self-energy, and vacuum polarization grow fast with increasing nuclear charge for a fixed configuration. The ratio of the velocity to length form of the transition rate (A{sub v}/A{sub l}) was used to estimate the accuracy of our calculations.
NASA Astrophysics Data System (ADS)
Garland, Ryan; Irwin, Patrick Gerard Joseph
2016-10-01
Exoplanetary and brown dwarf atmospheres are extremely diverse environments ranging over many different temperatures, pressures, and compositions. In order to model the spectra produced by the these objects, a commonplace approach in exoplanetary science is to use cross-sections of individual gases to quickly calculate the atmospheric opacities. However, when combining multiple gases with non-monochromatic absorption coefficients, the multiplication property of transmission does not hold. The resulting spectra are hence unreliable. Extensive work was carried out on Solar System radiative transfer models to find an efficient alternative to line-by-line calculations of opacity which was more accurate than combining cross-sections, resulting in many band models and the correlated-k method. Here we illustrate the effect of using cross-sections to model typical brown dwarf and exoplanetary atmospheres (e.g. HD189733b), and compare them to the spectra calculated using the correlated-k method. We verify our correlated-k method using a line-by-line model. For the same objects, we also present the effects of pressure broadening on the resulting spectra. Considering both the method of calculation (i.e. cross-section or correlated-k) and the treatment of pressure broadening, we show that the differences in the spectra are immediately obvious and hugely significant. Entire spectral features can appear or disappear, changing the morphology of the spectra. For the inspected brown dwarfs, these spectral features can vary by up to three orders of magnitude in luminosity. For our exoplanets, the transit depth can vary by up to 1%. We conclude that each effect would change the retrieved system parameters (i.e. temperature and abundances) considerably.
NASA Astrophysics Data System (ADS)
Rouge, C.; Lhémery, A.; Aristégui, C.; Walaszek, H.
2014-02-01
ElectroMagnetic Acoustic Transducers (EMATs) are contactless transducers generating ultrasonic waves in conductive media, notably shear horizontal and torsional waves (in plates and pipes, respectively), possibly in hostile environments. In a ferromagnetic part, the elastic strain and the magnetic field couple through magnetostriction phenomena, so that a magnetostriction and magnetization forces add up to the Lorentz force created in any conductive medium. Here, a model is proposed to predict these forces for an arbitrary bias field due to the EMAT permanent magnet and whatever the current intensity in its electric circuit, whereas the usual assumption of high bias field and low intensity current leads to important model simplifications. To handle the nonlinear behavior of all the three forces when the usual assumption cannot be made, forces are expressed in the time domain. In particular, magnetostriction force generates waves at several harmonic frequencies of the driving current frequency. Forces are then transformed into equivalent surface stresses readily usable as source terms in existing models of ultrasonic radiation, under the assumption that ultrasonic wavelengths are much longer than force penetration depths, (which is generally true in NDT applications of EMATs). Force spectra computed in various EMAT configurations are compared for illustration.
Rouge, C.; Lhémery, A.; Aristégui, C.; Walaszek, H.
2014-02-18
ElectroMagnetic Acoustic Transducers (EMATs) are contactless transducers generating ultrasonic waves in conductive media, notably shear horizontal and torsional waves (in plates and pipes, respectively), possibly in hostile environments. In a ferromagnetic part, the elastic strain and the magnetic field couple through magnetostriction phenomena, so that a magnetostriction and magnetization forces add up to the Lorentz force created in any conductive medium. Here, a model is proposed to predict these forces for an arbitrary bias field due to the EMAT permanent magnet and whatever the current intensity in its electric circuit, whereas the usual assumption of high bias field and low intensity current leads to important model simplifications. To handle the nonlinear behavior of all the three forces when the usual assumption cannot be made, forces are expressed in the time domain. In particular, magnetostriction force generates waves at several harmonic frequencies of the driving current frequency. Forces are then transformed into equivalent surface stresses readily usable as source terms in existing models of ultrasonic radiation, under the assumption that ultrasonic wavelengths are much longer than force penetration depths, (which is generally true in NDT applications of EMATs). Force spectra computed in various EMAT configurations are compared for illustration.
Gao, Yangyang; Müller-Plathe, Florian
2016-02-25
By employing reverse nonequilibrium molecular dynamics simulations in a full atomistic resolution, the effect of surface-grafted chains on the thermal conductivity of graphene-polyamide-6.6 (PA) nanocomposites has been investigated. The interfacial thermal conductivity perpendicular to the graphene plane is proportional to the grafting density, while it first increases and then saturates with the grafting length. Meanwhile, the intrinsic in-plane thermal conductivity of graphene drops sharply as the grafting density increases. The maximum overall thermal conductivity of nanocomposites appears at an intermediate grafting density because of these two competing effects. The thermal conductivity of the composite parallel to the graphene plane increases with the grafting density and grafting length which is attributed to better interfacial coupling between graphene and PA. There exists an optimal balance between grafting density and grafting length to obtain the highest interfacial and parallel thermal conductivity. Two empirical formulas are suggested, which quantitatively account for the effects of grafting length and density on the interfacial and parallel thermal conductivity. Combined with effective medium approximation, for ungrafted graphene in random orientation, the model overestimates the thermal conductivity at low graphene volume fraction (f < 10%) compared with experiments, while it underestimates it at high graphene volume fraction (f > 10%). For unoriented grafted graphene, the model matches the experimental results well. In short, this work provides some valuable guides to obtain the nanocomposites with high thermal conductivity by grafting chain on the surface of graphene.
Gao, Yangyang; Müller-Plathe, Florian
2016-02-25
By employing reverse nonequilibrium molecular dynamics simulations in a full atomistic resolution, the effect of surface-grafted chains on the thermal conductivity of graphene-polyamide-6.6 (PA) nanocomposites has been investigated. The interfacial thermal conductivity perpendicular to the graphene plane is proportional to the grafting density, while it first increases and then saturates with the grafting length. Meanwhile, the intrinsic in-plane thermal conductivity of graphene drops sharply as the grafting density increases. The maximum overall thermal conductivity of nanocomposites appears at an intermediate grafting density because of these two competing effects. The thermal conductivity of the composite parallel to the graphene plane increases with the grafting density and grafting length which is attributed to better interfacial coupling between graphene and PA. There exists an optimal balance between grafting density and grafting length to obtain the highest interfacial and parallel thermal conductivity. Two empirical formulas are suggested, which quantitatively account for the effects of grafting length and density on the interfacial and parallel thermal conductivity. Combined with effective medium approximation, for ungrafted graphene in random orientation, the model overestimates the thermal conductivity at low graphene volume fraction (f < 10%) compared with experiments, while it underestimates it at high graphene volume fraction (f > 10%). For unoriented grafted graphene, the model matches the experimental results well. In short, this work provides some valuable guides to obtain the nanocomposites with high thermal conductivity by grafting chain on the surface of graphene. PMID:26800434
Grant, C.; Mollerach, R.; Leszczynski, F.; Serra, O.; Marconi, J.; Fink, J.
2006-07-01
In 2005 the Argentine Government took the decision to complete the construction of the Atucha-II nuclear power plant, which has been progressing slowly during the last ten years. Atucha-II is a 745 MWe nuclear station moderated and cooled with heavy water, of German (Siemens) design located in Argentina. It has a pressure vessel design with 451 vertical coolant channels and the fuel assemblies (FA) are clusters of 37 natural UO{sub 2} rods with an active length of 530 cm. For the reactor physics area, a revision and update of reactor physics calculation methods and models was recently carried out covering cell, supercell (control rod) and core calculations. This paper presents benchmark comparisons of core parameters of a slightly idealized model of the Atucha-I core obtained with the PUMA reactor code with MCNP5. The Atucha-I core was selected because it is smaller, similar from a neutronic point of view, more symmetric than Atucha-II, and has some experimental data available. To validate the new models benchmark comparisons of k-effective, channel power and axial power distributions obtained with PUMA and MCNP5 have been performed. In addition, a simple cell heterogeneity correction recently introduced in PUMA is presented, which improves significantly the agreement of calculated channel powers with MCNP5. To complete the validation, the calculation of some of the critical configurations of the Atucha-I reactor measured during the experiments performed at first criticality is also presented. (authors)
Dibetsoe, Masego; Olasunkanmi, Lukman O; Fayemi, Omolola E; Yesudass, Sasikumar; Ramaganthan, Baskar; Bahadur, Indra; Adekunle, Abolanle S; Kabanda, Mwadham M; Ebenso, Eno E
2015-08-28
The effects of seven macrocyclic compounds comprising four phthalocyanines (Pcs) namely 1,4,8,11,15,18,22,25-octabutoxy-29H,31H-phthalocyanine (Pc1), 2,3,9,10,16,17,23,24-octakis(octyloxy)-29H,31H-phthalocyanine (Pc2), 2,9,16,23-tetra-tert-butyl-29H,31H-phthalocyanine (Pc3) and 29H,31H-phthalocyanine (Pc4), and three naphthalocyanines namely 5,9,14,18,23,27,32,36-octabutoxy-2,3-naphthalocyanine (nPc1), 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine (nPc2) and 2,3-naphthalocyanine (nP3) were investigated on the corrosion of aluminium (Al) in 1 M HCl using a gravimetric method, potentiodynamic polarization technique, quantum chemical calculations and quantitative structure activity relationship (QSAR). Synergistic effects of KI on the corrosion inhibition properties of the compounds were also investigated. All the studied compounds showed appreciable inhibition efficiencies, which decrease with increasing temperature from 30 °C to 70 °C. At each concentration of the inhibitor, addition of 0.1% KI increased the inhibition efficiency compared to the absence of KI indicating the occurrence of synergistic interactions between the studied molecules and I(-) ions. From the potentiodynamic polarization studies, the studied Pcs and nPcs are mixed type corrosion inhibitors both without and with addition of KI. The adsorption of the studied molecules on Al surface obeys the Langmuir adsorption isotherm, while the thermodynamic and kinetic parameters revealed that the adsorption of the studied compounds on Al surface is spontaneous and involves competitive physisorption and chemisorption mechanisms. The experimental results revealed the aggregated interactions between the inhibitor molecules and the results further indicated that the peripheral groups on the compounds affect these interactions. The calculated quantum chemical parameters and the QSAR results revealed the possibility of strong interactions between the studied inhibitors and metal surface. QSAR analysis on the
Dibetsoe, Masego; Olasunkanmi, Lukman O; Fayemi, Omolola E; Yesudass, Sasikumar; Ramaganthan, Baskar; Bahadur, Indra; Adekunle, Abolanle S; Kabanda, Mwadham M; Ebenso, Eno E
2015-01-01
The effects of seven macrocyclic compounds comprising four phthalocyanines (Pcs) namely 1,4,8,11,15,18,22,25-octabutoxy-29H,31H-phthalocyanine (Pc1), 2,3,9,10,16,17,23,24-octakis(octyloxy)-29H,31H-phthalocyanine (Pc2), 2,9,16,23-tetra-tert-butyl-29H,31H-phthalocyanine (Pc3) and 29H,31H-phthalocyanine (Pc4), and three naphthalocyanines namely 5,9,14,18,23,27,32,36-octabutoxy-2,3-naphthalocyanine (nPc1), 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine (nPc2) and 2,3-naphthalocyanine (nP3) were investigated on the corrosion of aluminium (Al) in 1 M HCl using a gravimetric method, potentiodynamic polarization technique, quantum chemical calculations and quantitative structure activity relationship (QSAR). Synergistic effects of KI on the corrosion inhibition properties of the compounds were also investigated. All the studied compounds showed appreciable inhibition efficiencies, which decrease with increasing temperature from 30 °C to 70 °C. At each concentration of the inhibitor, addition of 0.1% KI increased the inhibition efficiency compared to the absence of KI indicating the occurrence of synergistic interactions between the studied molecules and I(-) ions. From the potentiodynamic polarization studies, the studied Pcs and nPcs are mixed type corrosion inhibitors both without and with addition of KI. The adsorption of the studied molecules on Al surface obeys the Langmuir adsorption isotherm, while the thermodynamic and kinetic parameters revealed that the adsorption of the studied compounds on Al surface is spontaneous and involves competitive physisorption and chemisorption mechanisms. The experimental results revealed the aggregated interactions between the inhibitor molecules and the results further indicated that the peripheral groups on the compounds affect these interactions. The calculated quantum chemical parameters and the QSAR results revealed the possibility of strong interactions between the studied inhibitors and metal surface. QSAR analysis on the
ERIC Educational Resources Information Center
Miranda, R.
1989-01-01
Described is a heterogeneous catalysis course which has elements of materials processing embedded in the classical format of catalytic mechanisms and surface chemistry. A course outline and list of examples of recent review papers written by students are provided. (MVL)
Molecular Dynamics Simulations for Neutrino Scattering in Heterogeneous High Dense Media
Caballero, O. L.
2008-03-13
The dynamics of core-collapse supernovae is sensitive to neutrino scattering. Using molecular dynamics simulations, we calculated ion static structure factors and neutrino mean free paths. We simulated the stellar medium as composed in one case by single ion specie, and in the other by a mixture of ions. For the heterogeneous plasma we used two different models and systematically found the neutrino mean free path is shorter for an ion mixture.
Charge heterogeneity of surfaces: mapping and effects on surface forces.
Drelich, Jaroslaw; Wang, Yu U
2011-07-11
The DLVO theory treats the total interaction force between two surfaces in a liquid medium as an arithmetic sum of two components: Lifshitz-van der Waals and electric double layer forces. Despite the success of the DLVO model developed for homogeneous surfaces, a vast majority of surfaces of particles and materials in technological systems are of a heterogeneous nature with a mosaic structure composed of microscopic and sub-microscopic domains of different surface characteristics. In such systems, the heterogeneity of the surface can be more important than the average surface character. Attractions can be stronger, by orders of magnitude, than would be expected from the classical mean-field DLVO model when area-averaged surface charge or potential is employed. Heterogeneity also introduces anisotropy of interactions into colloidal systems, vastly ignored in the past. To detect surface heterogeneities, analytical tools which provide accurate and spatially resolved information about material surface chemistry and potential - particularly at microscopic and sub-microscopic resolutions - are needed. Atomic force microscopy (AFM) offers the opportunity to locally probe not only changes in material surface characteristic but also charges of heterogeneous surfaces through measurements of force-distance curves in electrolyte solutions. Both diffuse-layer charge densities and potentials can be calculated by fitting the experimental data with a DLVO theoretical model. The surface charge characteristics of the heterogeneous substrate as recorded by AFM allow the charge variation to be mapped. Based on the obtained information, computer modeling and simulation can be performed to study the interactions among an ensemble of heterogeneous particles and their collective motions. In this paper, the diffuse-layer charge mapping by the AFM technique is briefly reviewed, and a new Diffuse Interface Field Approach to colloid modeling and simulation is briefly discussed.
The imprint of crustal density heterogeneities on seismic wave propagation
NASA Astrophysics Data System (ADS)
Plonka, A.; Fichtner, A.
2015-12-01
We present the results of a set of numerical experiments designed to observe the imprint of three-dimensional density heterogeneities on a seismogram. To compute the full seismic wavefield in a three-dimensional heterogeneous medium, we use numerical wave propagation based on a spectral-element discretization of the seismic wave equation. We consider a 2000 by 1000 km wide and 500 km deep spherical section, with the one-dimensional Earth model PREM, altered so that the crust is 40 km thick and all the parameters in the crust are constant, as a background. Onto the uppermost 40 km of the underlying one-dimensional model we superimpose three-dimensional randomly generated velocity and density heterogeneities of various correlation lengths. We use different random realizations of heterogeneity distribution. We compare the synthetic seismograms for three-dimensional velocity and density structure with three-dimensional velocity structure and one-dimensional density kept as PREM, calculating relative amplitude differences and time shifts as functions of time and frequency. The misfits in time shift and amplitude for different frequency bands, epicentral distances and medium complexities are then stacked into histograms and statistically analysed. We observe strong dependency on frequency of density-related amplitude difference. We also conclude potential sensitivity to distant density structures, and that scattering is essential to observe significant density imprint on a seismogram. The possible density-related bias in velocity and attenuation for regional tomographic models is calculated using mean misfit values for given epicentral distances. Whereas the bias in velocity does not exceed 0.5% of the model value, the density-related change in attenuation may be as big as 71% of the model value for the mean amplitude difference in the highest frequency band. The results suggest that density imprint on a seismogram is not negligible and with further theoretical
Scales of mantle heterogeneity
NASA Astrophysics Data System (ADS)
Moore, J. C.; Akber-Knutson, S.; Konter, J.; Kellogg, J.; Hart, S.; Kellogg, L. H.; Romanowicz, B.
2004-12-01
A long-standing question in mantle dynamics concerns the scale of heterogeneity in the mantle. Mantle convection tends to both destroy (through stirring) and create (through melt extraction and subduction) heterogeneity in bulk and trace element composition. Over time, these competing processes create variations in geochemical composition along mid-oceanic ridges and among oceanic islands, spanning a range of scales from extremely long wavelength (for example, the DUPAL anomaly) to very small scale (for example, variations amongst melt inclusions). While geochemical data and seismic observations can be used to constrain the length scales of mantle heterogeneity, dynamical mixing calculations can illustrate the processes and timescales involved in stirring and mixing. At the Summer 2004 CIDER workshop on Relating Geochemical and Seismological Heterogeneity in the Earth's Mantle, an interdisciplinary group evaluated scales of heterogeneity in the Earth's mantle using a combined analysis of geochemical data, seismological data and results of numerical models of mixing. We mined the PetDB database for isotopic data from glass and whole rock analyses for the Mid-Atlantic Ridge (MAR) and the East Pacific Rise (EPR), projecting them along the ridge length. We examined Sr isotope variability along the East Pacific rise by looking at the difference in Sr ratio between adjacent samples as a function of distance between the samples. The East Pacific Rise exhibits an overall bowl shape of normal MORB characteristics, with higher values in the higher latitudes (there is, however, an unfortunate gap in sampling, roughly 2000 km long). These background characteristics are punctuated with spikes in values at various locations, some, but not all of which are associated with off-axis volcanism. A Lomb-Scargle periodogram for unevenly spaced data was utilized to construct a power spectrum of the scale lengths of heterogeneity along both ridges. Using the same isotopic systems (Sr, Nd
Rana, Suresh B.
2013-01-01
Purpose: It is well known that photon beam radiation therapy requires dose calculation algorithms. The objective of this study was to measure and assess the ability of pencil beam convolution (PBC) and anisotropic analytical algorithm (AAA) to predict doses beyond high density heterogeneity. Materials and Methods: An inhomogeneous phantom of five layers was created in Eclipse planning system (version 8.6.15). Each layer of phantom was assigned in terms of water (first or top), air (second), water (third), bone (fourth), and water (fifth or bottom) medium. Depth doses in water (bottom medium) were calculated for 100 monitor units (MUs) with 6 Megavoltage (MV) photon beam for different field sizes using AAA and PBC with heterogeneity correction. Combinations of solid water, Poly Vinyl Chloride (PVC), and Styrofoam were then manufactured to mimic phantoms and doses for 100 MUs were acquired with cylindrical ionization chamber at selected depths beyond high density heterogeneity interface. The measured and calculated depth doses were then compared. Results: AAA's values had better agreement with measurements at all measured depths. Dose overestimation by AAA (up to 5.3%) and by PBC (up to 6.7%) was found to be higher in proximity to the high-density heterogeneity interface, and the dose discrepancies were more pronounced for larger field sizes. The errors in dose estimation by AAA and PBC may be due to improper beam modeling of primary beam attenuation or lateral scatter contributions or combination of both in heterogeneous media that include low and high density materials. Conclusions: AAA is more accurate than PBC for dose calculations in treating deep-seated tumor beyond high-density heterogeneity interface. PMID:24455541
NASA Astrophysics Data System (ADS)
Lokajíček, T.; Kern, H.; Svitek, T.; Ivankina, T.
2014-06-01
Ultrasonic measurements of the 3D velocity distribution of P- and S-waves were performed on a spherical sample of a biotite gneiss from the Outokumpu scientific drill hole. Measurements were done at room temperature and pressures up to 400 and 70 MPa, respectively, in a pressure vessel with oil as a pressure medium. A modified transducer/sample assembly and the installation of a new mechanical system allowed simultaneous measurements of P- and S-wave velocities in 132 independent directions of the sphere on a net in steps of 15°. Proper signals for P- and S-waves could be recorded by coating the sample surface with a high-viscosity shear wave gel and by temporal point contacting of the transmitter and receiver transducers with the sample surface during the measurements. The 3D seismic measurements revealed a strong foliation-related directional dependence (anisotropy) of P- and S-wave velocities, which is confirmed by measurements in a multi-anvil apparatus on a cube-shaped specimen of the same rock. Both experimental approaches show a marked pressure sensitivity of P- and S-wave velocities and velocity anisotropies. With increasing pressure, P- and S-wave velocities increase non-linearly due to progressive closure of micro-cracks. The reverse is true for velocity anisotropy. 3D velocity calculations based on neutron diffraction measurements of crystallographic preferred orientation (CPO) of major minerals show that the intrinsic bulk anisotropy is basically caused by the CPO of biotite constituting about 23 vol.% of the rock. Including the shape of biotite grains and oriented low-aspect ratio microcracks into the modelling increases bulk anisotropy. An important finding from this study is that the measurements on the sample sphere and on the sample cube displayed distinct differences, particularly in shear wave velocities. It is assumed that the differences are due to the different geometries of the samples and the configuration of the transducer-sample assembly
Dynamical quorum-sensing in oscillators coupled through an external medium
NASA Astrophysics Data System (ADS)
Schwab, David J.; Baetica, Ania; Mehta, Pankaj
2012-11-01
Many biological and physical systems exhibit population-density-dependent transitions to synchronized oscillations in a process often termed “dynamical quorum sensing”. Synchronization frequently arises through chemical communication via signaling molecules distributed through an external medium. We study a simple theoretical model for dynamical quorum sensing: a heterogenous population of limit-cycle oscillators diffusively coupled through a common medium. We show that this model exhibits a rich phase diagram with four qualitatively distinct physical mechanisms that can lead to a loss of coherent population-level oscillations, including a novel mechanism arising from effective time-delays introduced by the external medium. We derive a single pair of analytic equations that allow us to calculate phase boundaries as a function of population density and show that the model reproduces many of the qualitative features of recent experiments on Belousov-Zhabotinsky catalytic particles as well as synthetically engineered bacteria.
Reaction Selectivity in Heterogeneous Catalysis
Somorjai, Gabor A.; Kliewer, Christopher J.
2009-02-02
The understanding of selectivity in heterogeneous catalysis is of paramount importance to our society today. In this review we outline the current state of the art in research on selectivity in heterogeneous catalysis. Current in-situ surface science techniques have revealed several important features of catalytic selectivity. Sum frequency generation vibrational spectroscopy has shown us the importance of understanding the reaction intermediates and mechanism of a heterogeneous reaction, and can readily yield information as to the effect of temperature, pressure, catalyst geometry, surface promoters, and catalyst composition on the reaction mechanism. DFT calculations are quickly approaching the ability to assist in the interpretation of observed surface spectra, thereby making surface spectroscopy an even more powerful tool. HP-STM has revealed three vitally important parameters in heterogeneous selectivity: adsorbate mobility, catalyst mobility, and selective site-blocking. The development of size controlled nanoparticles from 0.8 to 10 nm, of controlled shape, and of controlled bimetallic composition has revealed several important variables for catalytic selectivity. Lastly, DFT calculations may be paving the way to guiding the composition choice for multi-metallic heterogeneous catalysis for the intelligent design of catalysts incorporating the many factors of selectivity we have learned.
Heterogeneity in Sedimentary Aquifers: Effects on Chlorinated Solvent Mass Storage
NASA Astrophysics Data System (ADS)
Kalinovich, I. K.; Allen-King, R.; Carlone, D.; Clarke, D.; George, S. S.; Weissmann, G. S.; McNamara, K. C.; Frechette, J. D.
2011-12-01
Dynamic mass storage of hydrophobic organic contaminants (HOC) is affected by physical and geochemical aquifer heterogeneities, creating a need for targeted remediation. In glacially-derived aquifers (such as the well-known Borden study site), sedimentary lithocomponents contain varying types and quantities of highly-sorbing carbonaceous matter. These lithocomponents are distributed throughout the aquifer through transport and depositional processes. Compared to fine-grained lithofacies, lithofacies with greater texture have increased magnitudes and variability of Kd (equilibrium sorption coefficient) due to lithocomponent variety and deposition. Sedimentological features with greater physical and geochemical heterogeneity (such as scours and troughs) are potential areas for mass storage of HOCs, requiring targeted remediation efforts. In this study, a spatial data set collected from the Borden study site is combined with a nearby outcrop analogue to investigate how geochemical and physical heterogeneity influences the mass storage of HOCs. Outcrop analogue-derived lithofacies from a nearby sand quarry allow us to quantify geochemical heterogeneity in the sedimentary architectural context. Each scour feature consists of several sediment facies layered on top of one another in identifiable and predictable patterns. These patterns extend beyond the massive packages of medium grained facies; they include fine grained facies toward the top of the scour. Outcrop investigations of spatial deposition of lithocomponents and Kd analysis shows that areas of increased lateral heterogeneity and overall Kd magnitude are associated with the sharp contact at the bottom of these scours with fine-grained facies. Both lateral heterogeneity and Kd are associated with the abundance of dark and light carbonaceous lithocomponents. Particle size, lithocomponent analysis and distinct cumulative density functions for Kd (of chlorinated volatile organic compounds) were derived for
Farzad Rahnema
2003-09-30
Most modern nodal methods in use by the reactor vendors and utilities are based on the generalized equivalence theory (GET) that uses homogenized cross sections and flux discontinuity factors. These homogenized parameters, referred to as infinite medium parameters, are precomputed by performing single bundle fine-mesh calculations with zero current boundary conditions. It is known that for configurations in which the node-to-node leakage (e.g., surface current-to-flux ratio) is large the use of the infinite medium parameters could lead to large errors in the nodal solution. This would be the case for highly heterogeneous core configurations, typical of modern reactor core designs.
Dispersivity in heterogeneous permeable media
Chesnut, D.A.
1994-01-01
When one fluid displaces another through a one-dimensional porous medium, the composition changes from pure displacing fluid at the inlet to pure displaced fluid some distance downstream. The distance over which an arbitrary percentage of this change occurs is defined as the mixing zone length, which increases with increasing average distance traveled by the displacement front. For continuous injection, the mixing zone size can be determined from a breakthrough curve as the time required for the effluent displacing fluid concentration to change from, say, 10% to 90%. In classical dispersion theory, the mixing zone grows in proportion to the square root of the mean distance traveled, or, equivalently, to the square root of the mean breakthrough time. In a multi-dimensional heterogeneous medium, especially at field scales, the size of the mixing zone grows almost linearly with mean distance or travel time. If an observed breakthrough curve is forced to fit the, clinical theory, the resulting effective dispersivity, instead of being constant, also increases almost linearly with the spatial or temporal scale of the problem. This occurs because the heterogeneity in flow properties creates a corresponding velocity distribution along the different flow pathways from the inlet to the outlet of the system. Mixing occurs mostly at the outlet, or wherever the fluid is sampled, rather than within the medium. In this paper, we consider the effects. of this behavior on radionuclide or other contaminant migration.
Disordered hyperuniform heterogeneous materials
NASA Astrophysics Data System (ADS)
Torquato, Salvatore
2016-10-01
Disordered hyperuniform many-body systems are distinguishable states of matter that lie between a crystal and liquid: they are like perfect crystals in the way they suppress large-scale density fluctuations and yet are like liquids or glasses in that they are statistically isotropic with no Bragg peaks. These systems play a vital role in a number of fundamental and applied problems: glass formation, jamming, rigidity, photonic and electronic band structure, localization of waves and excitations, self-organization, fluid dynamics, quantum systems, and pure mathematics. Much of what we know theoretically about disordered hyperuniform states of matter involves many-particle systems. In this paper, we derive new rigorous criteria that disordered hyperuniform two-phase heterogeneous materials must obey and explore their consequences. Two-phase heterogeneous media are ubiquitous; examples include composites and porous media, biological media, foams, polymer blends, granular media, cellular solids, and colloids. We begin by obtaining some results that apply to hyperuniform two-phase media in which one phase is a sphere packing in d-dimensional Euclidean space {{{R}}d} . Among other results, we rigorously establish the requirements for packings of spheres of different sizes to be ‘multihyperuniform’. We then consider hyperuniformity for general two-phase media in {{{R}}d} . Here we apply realizability conditions for an autocovariance function and its associated spectral density of a two-phase medium, and then incorporate hyperuniformity as a constraint in order to derive new conditions. We show that some functional forms can immediately be eliminated from consideration and identify other forms that are allowable. Specific examples and counterexamples are described. Contact is made with well-known microstructural models (e.g. overlapping spheres and checkerboards) as well as irregular phase-separation and Turing-type patterns. We also ascertain a family of
Disordered hyperuniform heterogeneous materials.
Torquato, Salvatore
2016-10-19
Disordered hyperuniform many-body systems are distinguishable states of matter that lie between a crystal and liquid: they are like perfect crystals in the way they suppress large-scale density fluctuations and yet are like liquids or glasses in that they are statistically isotropic with no Bragg peaks. These systems play a vital role in a number of fundamental and applied problems: glass formation, jamming, rigidity, photonic and electronic band structure, localization of waves and excitations, self-organization, fluid dynamics, quantum systems, and pure mathematics. Much of what we know theoretically about disordered hyperuniform states of matter involves many-particle systems. In this paper, we derive new rigorous criteria that disordered hyperuniform two-phase heterogeneous materials must obey and explore their consequences. Two-phase heterogeneous media are ubiquitous; examples include composites and porous media, biological media, foams, polymer blends, granular media, cellular solids, and colloids. We begin by obtaining some results that apply to hyperuniform two-phase media in which one phase is a sphere packing in d-dimensional Euclidean space [Formula: see text]. Among other results, we rigorously establish the requirements for packings of spheres of different sizes to be 'multihyperuniform'. We then consider hyperuniformity for general two-phase media in [Formula: see text]. Here we apply realizability conditions for an autocovariance function and its associated spectral density of a two-phase medium, and then incorporate hyperuniformity as a constraint in order to derive new conditions. We show that some functional forms can immediately be eliminated from consideration and identify other forms that are allowable. Specific examples and counterexamples are described. Contact is made with well-known microstructural models (e.g. overlapping spheres and checkerboards) as well as irregular phase-separation and Turing-type patterns. We also ascertain a family
Microswimmers in Complex Environments with Heterogeneous Microstructure
NASA Astrophysics Data System (ADS)
Hyon, Yunkyong; Fu, Henry
2011-11-01
We will discuss the swimming of microorganisms in complex and heterogeneous environments. Microswimmers in biological complex fluids, for instance, bacteria and sperm, are often greatly influenced by heterogeneous medium microstructure with length scales comparable to themselves. We characterize the interaction between the microswimmer and the medium microstructure using the model Golestanian three-sphere swimmer, treating the hydrodynamic interaction with the microstructure through the Oseen tensor. In this investigation, the microstructure of the heterogeneous environment is modeled by fixed spheres representing obstacles, or chains consisting of spheres connected with elastic springs. We find that the swimming speed of the swimmer depends on the force and deformation exerted on micro-structure. Furthermore, we find that while short freely suspended chains and short chains anchored at their ends interact with swimmer quite differently, long enough chains interact similarly, that is, a long mobile chain acts like a anchored chain. We discuss the implications for swimmer interactions with polymer solutions and compliant networks.
Heterogeneous Responses of Chinese Cities' Housing Prices to Monetary Policies
NASA Astrophysics Data System (ADS)
Yan, Yan; Wang, Yan-Ting; Zhu, Xiao-Wu
2011-10-01
This works examine the responses of housing prices to the monetary policies in various Chinese cities. Thirty-five large and medium sized Chinese cities are classified into six clusters applying the minimum variance clustering method according to the calculated correlation coefficients between the housing price indices of every two cities. Time difference correlation analysis is then employed to quantify the relations between the housing price indices of the six clusters and the monetary policies. It is suggested that the housing prices of various cities evolved at different paces and their responses to the monetary policies are heterogeneous, and local economic features are more important than geographic distances in determining the housing price trends.
NASA Astrophysics Data System (ADS)
Paiva Fonseca, Gabriel; Carlsson Tedgren, Åsa; Reniers, Brigitte; Nilsson, Josef; Persson, Maria; Yoriyaz, Hélio; Verhaegen, Frank
2015-06-01
Dose calculation in high dose rate brachytherapy with 192Ir is usually based on the TG-43U1 protocol where all media are considered to be water. Several dose calculation algorithms have been developed that are capable of handling heterogeneities with two possibilities to report dose: dose-to-medium-in-medium (Dm,m) and dose-to-water-in-medium (Dw,m). The relation between Dm,m and Dw,m for 192Ir is the main goal of this study, in particular the dependence of Dw,m on the dose calculation approach using either large cavity theory (LCT) or small cavity theory (SCT). A head and neck case was selected due to the presence of media with a large range of atomic numbers relevant to tissues and mass densities such as air, soft tissues and bone interfaces. This case was simulated using a Monte Carlo (MC) code to score: Dm,m, Dw,m (LCT), mean photon energy and photon fluence. Dw,m (SCT) was derived from MC simulations using the ratio between the unrestricted collisional stopping power of the actual medium and water. Differences between Dm,m and Dw,m (SCT or LCT) can be negligible (<1%) for some tissues e.g. muscle and significant for other tissues with differences of up to 14% for bone. Using SCT or LCT approaches leads to differences between Dw,m (SCT) and Dw,m (LCT) up to 29% for bone and 36% for teeth. The mean photon energy distribution ranges from 222 keV up to 356 keV. However, results obtained using mean photon energies are not equivalent to the ones obtained using the full, local photon spectrum. This work concludes that it is essential that brachytherapy studies clearly report the dose quantity. It further shows that while differences between Dm,m and Dw,m (SCT) mainly depend on tissue type, differences between Dm,m and Dw,m (LCT) are, in addition, significantly dependent on the local photon energy fluence spectrum which varies with distance to implanted sources.
Abdallah, Batoul Y; Horne, Steven D; Stevens, Joshua B; Liu, Guo; Ying, Andrew Y; Vanderhyden, Barbara; Krawetz, Stephen A; Gorelick, Root; Heng, Henry HQ
2013-01-01
Multi-level heterogeneity is a fundamental but underappreciated feature of cancer. Most technical and analytical methods either completely ignore heterogeneity or do not fully account for it, as heterogeneity has been considered noise that needs to be eliminated. We have used single-cell and population-based assays to describe an instability-mediated mechanism where genome heterogeneity drastically affects cell growth and cannot be accurately measured using conventional averages. First, we show that most unstable cancer cell populations exhibit high levels of karyotype heterogeneity, where it is difficult, if not impossible, to karyotypically clone cells. Second, by comparing stable and unstable cell populations, we show that instability-mediated karyotype heterogeneity leads to growth heterogeneity, where outliers dominantly contribute to population growth and exhibit shorter cell cycles. Predictability of population growth is more difficult for heterogeneous cell populations than for homogenous cell populations. Since “outliers” play an important role in cancer evolution, where genome instability is the key feature, averaging methods used to characterize cell populations are misleading. Variances quantify heterogeneity; means (averages) smooth heterogeneity, invariably hiding it. Cell populations of pathological conditions with high genome instability, like cancer, behave differently than karyotypically homogeneous cell populations. Single-cell analysis is thus needed when cells are not genomically identical. Despite increased attention given to single-cell variation mediated heterogeneity of cancer cells, continued use of average-based methods is not only inaccurate but deceptive, as the “average” cancer cell clearly does not exist. Genome-level heterogeneity also may explain population heterogeneity, drug resistance, and cancer evolution. PMID:24091732
Mashouf, S; Lai, P; Karotki, A; Keller, B; Beachey, D; Pignol, J
2014-06-01
Purpose: Seed brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose surrounding the brachytherapy seeds is based on American Association of Physicist in Medicine Task Group No. 43 (TG-43 formalism) which generates the dose in homogeneous water medium. Recently, AAPM Task Group No. 186 emphasized the importance of accounting for tissue heterogeneities. This can be done using Monte Carlo (MC) methods, but it requires knowing the source structure and tissue atomic composition accurately. In this work we describe an efficient analytical dose inhomogeneity correction algorithm implemented using MIM Symphony treatment planning platform to calculate dose distributions in heterogeneous media. Methods: An Inhomogeneity Correction Factor (ICF) is introduced as the ratio of absorbed dose in tissue to that in water medium. ICF is a function of tissue properties and independent of source structure. The ICF is extracted using CT images and the absorbed dose in tissue can then be calculated by multiplying the dose as calculated by the TG-43 formalism times ICF. To evaluate the methodology, we compared our results with Monte Carlo simulations as well as experiments in phantoms with known density and atomic compositions. Results: The dose distributions obtained through applying ICF to TG-43 protocol agreed very well with those of Monte Carlo simulations as well as experiments in all phantoms. In all cases, the mean relative error was reduced by at least 50% when ICF correction factor was applied to the TG-43 protocol. Conclusion: We have developed a new analytical dose calculation method which enables personalized dose calculations in heterogeneous media. The advantages over stochastic methods are computational efficiency and the ease of integration into clinical setting as detailed source structure and tissue segmentation are not needed. University of Toronto, Natural Sciences and
A simplified analytical random walk model for proton dose calculation
NASA Astrophysics Data System (ADS)
Yao, Weiguang; Merchant, Thomas E.; Farr, Jonathan B.
2016-10-01
We propose an analytical random walk model for proton dose calculation in a laterally homogeneous medium. A formula for the spatial fluence distribution of primary protons is derived. The variance of the spatial distribution is in the form of a distance-squared law of the angular distribution. To improve the accuracy of dose calculation in the Bragg peak region, the energy spectrum of the protons is used. The accuracy is validated against Monte Carlo simulation in water phantoms with either air gaps or a slab of bone inserted. The algorithm accurately reflects the dose dependence on the depth of the bone and can deal with small-field dosimetry. We further applied the algorithm to patients’ cases in the highly heterogeneous head and pelvis sites and used a gamma test to show the reasonable accuracy of the algorithm in these sites. Our algorithm is fast for clinical use.
Effects of ionization chamber construction on dose measurements in a heterogeneity
Mauceri, T.; Kase, K.
1987-07-01
Traditionally, measurements have been made in heterogeneous phantoms to determine the factors which should be applied to dose calculations, when calculating a dose to a heterogeneous medium. Almost all measurements have relied on relatively thin-walled ion chambers, with no attempt to match ion chamber wall material to the measuring medium. The recent AAPM dosimetry protocol has established that a mismatch between ion chamber wall and phantom material can have an effect on dose measurement. To investigate the affect of this mismatch of ion chamber wall material to phantom material, two parallel-plate ion chambers were constructed. One ion chamber from solid water, for measurements in a solid water phantom and the other from plastic lung material, for measurements in a plastic lung material phantom. Correction factors measured by matching ion chamber to media were compared to correction factors measured by using a thin-walled cavity ion chamber with no regard for matching wall and media for cobalt-60, 6-, 10- and 20-MV photon beams. The results demonstrated that the matching of ion chamber to measuring media can be ignored, provided that a small, approximately tissue-equivalent, thin-walled ion chamber is used for measuring the correction factors.
Phenotypically heterogeneous populations in spatially heterogeneous environments
NASA Astrophysics Data System (ADS)
Patra, Pintu; Klumpp, Stefan
2014-03-01
The spatial expansion of a population in a nonuniform environment may benefit from phenotypic heterogeneity with interconverting subpopulations using different survival strategies. We analyze the crossing of an antibiotic-containing environment by a bacterial population consisting of rapidly growing normal cells and slow-growing, but antibiotic-tolerant persister cells. The dynamics of crossing is characterized by mean first arrival times and is found to be surprisingly complex. It displays three distinct regimes with different scaling behavior that can be understood based on an analytical approximation. Our results suggest that a phenotypically heterogeneous population has a fitness advantage in nonuniform environments and can spread more rapidly than a homogeneous population.
Vesnov, I G
2010-06-23
An improved mathematical model describing the dissociation and regenerations kinetics of carbon dioxide in the active medium of sealed-off transverse RF-excited CO{sub 2} lasers is presented. It is shown that the calculation of the active medium composition of such lasers requires the equations of the gas-mixture kinetics to take into account the diffuse flow of oxygen atoms on metal electrodes and on the surface of heterogeneous catalysts used to reduce the degree of the carbon dioxide dissociation. The rate constants of the heterogeneous recombination reaction CO + O {yields} CO{sub 2} on the surface of alumina ceramics and Al{sub 2}O{sub 3} are determined. (active media)
Patterns of Emphysema Heterogeneity
Valipour, Arschang; Shah, Pallav L.; Gesierich, Wolfgang; Eberhardt, Ralf; Snell, Greg; Strange, Charlie; Barry, Robert; Gupta, Avina; Henne, Erik; Bandyopadhyay, Sourish; Raffy, Philippe; Yin, Youbing; Tschirren, Juerg; Herth, Felix J.F.
2016-01-01
Background Although lobar patterns of emphysema heterogeneity are indicative of optimal target sites for lung volume reduction (LVR) strategies, the presence of segmental, or sublobar, heterogeneity is often underappreciated. Objective The aim of this study was to understand lobar and segmental patterns of emphysema heterogeneity, which may more precisely indicate optimal target sites for LVR procedures. Methods Patterns of emphysema heterogeneity were evaluated in a representative cohort of 150 severe (GOLD stage III/IV) chronic obstructive pulmonary disease (COPD) patients from the COPDGene study. High-resolution computerized tomography analysis software was used to measure tissue destruction throughout the lungs to compute heterogeneity (≥ 15% difference in tissue destruction) between (inter-) and within (intra-) lobes for each patient. Emphysema tissue destruction was characterized segmentally to define patterns of heterogeneity. Results Segmental tissue destruction revealed interlobar heterogeneity in the left lung (57%) and right lung (52%). Intralobar heterogeneity was observed in at least one lobe of all patients. No patient presented true homogeneity at a segmental level. There was true homogeneity across both lungs in 3% of the cohort when defining heterogeneity as ≥ 30% difference in tissue destruction. Conclusion Many LVR technologies for treatment of emphysema have focused on interlobar heterogeneity and target an entire lobe per procedure. Our observations suggest that a high proportion of patients with emphysema are affected by interlobar as well as intralobar heterogeneity. These findings prompt the need for a segmental approach to LVR in the majority of patients to treat only the most diseased segments and preserve healthier ones. PMID:26430783
Gay, Laura; Baker, Ann-Marie; Graham, Trevor A.
2016-01-01
The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment. PMID:26973786
Quantifying lateral tissue heterogeneities in hadron therapy
Pflugfelder, D.; Wilkens, J. J.; Szymanowski, H.; Oelfke, U.
2007-04-15
In radiotherapy with scanned particle beams, tissue heterogeneities lateral to the beam direction are problematic in two ways: they pose a challenge to dose calculation algorithms, and they lead to a high sensitivity to setup errors. In order to quantify and avoid these problems, a heterogeneity number H{sub i} as a method to quantify lateral tissue heterogeneities of single beam spot i is introduced. To evaluate this new concept, two kinds of potential errors were investigated for single beam spots: First, the dose calculation error has been obtained by comparing the dose distribution computed by a simple pencil beam algorithm to more accurate Monte Carlo simulations. The resulting error is clearly correlated with H{sub i}. Second, the analysis of the sensitivity to setup errors of single beam spots also showed a dependence on H{sub i}. From this data it is concluded that H{sub i} can be used as a criterion to assess the risks of a compromised delivered dose due to lateral tissue heterogeneities. Furthermore, a method how to incorporate this information into the inverse planning process for intensity modulated proton therapy is presented. By suppressing beam spots with a high value of H{sub i}, the unfavorable impact of lateral tissue heterogeneities can be reduced, leading to treatment plans which are more robust to dose calculation errors of the pencil beam algorithm. Additional possibilities to use the information of H{sub i} are outlined in the discussion.
Shock velocity increase due to a heterogeneity produced by a two-gas layer.
Elbaz, Déborah; Jourdan, Georges; Houas, Lazhar; Jaouen, Stéphane; Ballereau, Philippe; Dias, Frédéric; Canaud, Benoit
2012-06-01
Shock tube experiments are performed in order to study shock propagation along a two-gas layer in a confined geometry and to compare it to the case of a homogeneous density equivalent mixture. The analysis of the homogeneous case gives values for the adiabatic coefficient and density of the mixture of both gases, while the comparison between heterogeneous and homogeneous media with the same averaged density shows modifications of the shock front shape and velocity. In the two-gas layer, the shock propagates faster than in the homogeneous medium. The shock front is curved with a triple point which appears close to the shock-tube wall, in the slow medium, while it stays planar during its whole propagation in the homogeneous mixture. A correlation is found between the angle of curvature and the shock velocity increase. It is confirmed by two-dimensional Eulerian numerical calculations. Experiments and calculations exhibit very good agreement on all the measurements when molecular diffusion is taken into account in the numerical calculations. A sustained irregular refraction pattern of the shock front at the diffuse interface of both gases is obtained experimentally and confirmed by the calculations.
Medium modifications with recoil polarization
Brand, J.F.J. van den; Ent, R.
1994-04-01
The authors show that the virtual Compton scattering process allows for a precise study of the off-shell electron-nucleon vertex. In a separable model, they show the sensitivity to new unconstrained structure functions of the nucleon, beyond the usual Dirac and Pauli form factors. In addition, they show the sensitivity to bound nucleon form factors using the reaction 4He({rvec e},e{prime},{rvec p}){sup 3}H. A nucleon embedded in a nucleus represents a complex system. Firstly, the bound nucleon is necessarily off-shell and in principle a complete understanding of the dynamical structure of the nucleon is required in order to calculate its off-shell electromagnetic interaction. Secondly, one faces the possibility of genuine medium effects, such as for example quark-exchange contributions. Furthermore, the electromagnetic coupling to the bound nucleon is dependent on the nuclear dynamics through the self-energy of the nucleon in the nuclear medium.
NASA Astrophysics Data System (ADS)
Yang, X.; Zhu, P.; Gu, Y.; Xu, Z.
2015-12-01
Small scale heterogeneities of subsurface medium can be characterized conveniently and effectively using a few simple random medium parameters (RMP), such as autocorrelation length, angle and roughness factor, etc. The estimation of these parameters is significant in both oil reservoir prediction and metallic mine exploration. Poor accuracy and low stability existed in current estimation approaches limit the application of random medium theory in seismic exploration. This study focuses on improving the accuracy and stability of RMP estimation from post-stacked seismic data and its application in the seismic inversion. Experiment and theory analysis indicate that, although the autocorrelation of random medium is related to those of corresponding post-stacked seismic data, the relationship is obviously affected by the seismic dominant frequency, the autocorrelation length, roughness factor and so on. Also the error of calculation of autocorrelation in the case of finite and discrete model decreases the accuracy. In order to improve the precision of estimation of RMP, we design two improved approaches. Firstly, we apply region growing algorithm, which often used in image processing, to reduce the influence of noise in the autocorrelation calculated by the power spectrum method. Secondly, the orientation of autocorrelation is used as a new constraint in the estimation algorithm. The numerical experiments proved that it is feasible. In addition, in post-stack seismic inversion of random medium, the estimated RMP may be used to constrain inverse procedure and to construct the initial model. The experiment results indicate that taking inversed model as random medium and using relatively accurate estimated RMP to construct initial model can get better inversion result, which contained more details conformed to the actual underground medium.
Interstellar medium simulations
NASA Astrophysics Data System (ADS)
Breitschwerdt, D.; de Avillez, M. A.; Feige, J.; Dettbarn, C.
2012-06-01
In this review we critically assess numerical simulations of the interstellar medium (ISM), and argue that 3D high resolution calculations are the most promising method to determine the structure of the interstellar gas and follow its evolution well into the nonlinear regime. Based on a Riemann solver adaptive mesh refinement code, we present a model, which fulfills the basic requirements of running it sufficiently long in order to erase memory effects of the initial conditions, set up a disk-halo fountain flow cycle, for converging solutions with increasing mesh refinement. We obtain the following results: (i) in a supernova driven ISM, high Reynolds number turbulence generates structures on all scales, (ii) the volume filling factor of the hot gas is substantially reduced due to the fountain flow, (iii) gas clouds are transient shock compressed layers, (iv) more than half of the gas mass resides in thermally unstable regimes, (v) O VI is distributed in patchy mixing layers, with the derived column densities being in agreement with FUSE and Copernicus observations, (vi) the electron density distribution up to distances of 8 kpc in the disk is consistent with pulsar dispersion measure observations, provided that the electron and ionization structure are not in equilibrium, (vii) the interstellar cooling function depends both on space and time (and not only on temperature and metallicity), (viii) the Local Bubble has been produced by 14-20 supernovae about 14 Myr ago, exploding in a moving group on its path through the local ISM, (ix) the nearest supernova explosion to Earth occurred 2.2 {×} 106 yr ago at a distance of {˜} 85 pc, in agreement with measurements of the radionuclide 60Fe found in the ferromanganese crust on the ocean floor.
Heterogeneous atmospheric chemistry
NASA Technical Reports Server (NTRS)
Schryer, D. R.
1982-01-01
The present conference on heterogeneous atmospheric chemistry considers such topics concerning clusters, particles and microparticles as common problems in nucleation and growth, chemical kinetics, and catalysis, chemical reactions with aerosols, electron beam studies of natural and anthropogenic microparticles, and structural studies employing molecular beam techniques, as well as such gas-solid interaction topics as photoassisted reactions, catalyzed photolysis, and heterogeneous catalysis. Also discussed are sulfur dioxide absorption, oxidation, and oxidation inhibition in falling drops, sulfur dioxide/water equilibria, the evidence for heterogeneous catalysis in the atmosphere, the importance of heterogeneous processes to tropospheric chemistry, soot-catalyzed atmospheric reactions, and the concentrations and mechanisms of formation of sulfate in the atmospheric boundary layer.
Teaching Heterogeneous Classes.
ERIC Educational Resources Information Center
Millrood, Radislav
2002-01-01
Discusses an approach to teaching heterogeneous English-as-a-Second/Foreign-Language classes. Draws on classroom research data to describe the features of a success-building lesson context. (Author/VWL)
Stokowski, Stanley E.
1989-01-01
A laser medium is particularly useful in high average power solid state lasers. The laser medium includes a chormium dopant and preferably neodymium ions as codopant, and is primarily a gadolinium scandium gallium garnet, or an analog thereof. Divalent cations inhibit spiral morphology as large boules from which the laser medium is derived are grown, and a source of ions convertible between a trivalent state and a tetravalent state at a low ionization energy are in the laser medium to reduce an absorption coefficient at about one micron wavelength otherwise caused by the divalent cations. These divalent cations and convertible ions are dispersed in the laser medium. Preferred convertible ions are provided from titanium or cerium sources.
Stokowski, S.E.
1987-10-20
A laser medium is particularly useful in high average power solid state lasers. The laser medium includes a chromium dopant and preferably neodymium ions as codopant, and is primarily a gadolinium scandium gallium garnet, or an analog thereof. Divalent cations inhibit spiral morphology as large boules from which the laser medium is derived are grown, and a source of ions convertible between a trivalent state and a tetravalent state at a low ionization energy are in the laser medium to reduce an absorption coefficient at about one micron wavelength otherwise caused by the divalent cations. These divalent cations and convertible ions are dispersed in the laser medium. Preferred convertible ions are provided from titanium or cerium sources.
Dose heterogeneity correction for low-energy brachytherapy sources using dual-energy CT images.
Mashouf, S; Lechtman, E; Lai, P; Keller, B M; Karotki, A; Beachey, D J; Pignol, J P
2014-09-21
Permanent seed implant brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose around brachytherapy sources is based on the AAPM TG-43 formalism, which generates the dose in a homogeneous water medium. Recently, AAPM TG-186 emphasized the importance of accounting for tissue heterogeneities. We have previously reported on a methodology where the absorbed dose in tissue can be obtained by multiplying the dose, calculated by the TG-43 formalism, by an inhomogeneity correction factor (ICF). In this work we make use of dual energy CT (DECT) images to extract ICF parameters. The advantage of DECT over conventional CT is that it eliminates the need for tissue segmentation as well as assignment of population based atomic compositions. DECT images of a heterogeneous phantom were acquired and the dose was calculated using both TG-43 and TG-43 [Formula: see text] formalisms. The results were compared to experimental measurements using Gafchromic films in the mid-plane of the phantom. For a seed implant configuration of 8 seeds spaced 1.5 cm apart in a cubic structure, the gamma passing score for 2%/2 mm criteria improved from 40.8% to 90.5% when ICF was applied to TG-43 dose distributions.
Dose heterogeneity correction for low-energy brachytherapy sources using dual-energy CT images
NASA Astrophysics Data System (ADS)
Mashouf, S.; Lechtman, E.; Lai, P.; Keller, B. M.; Karotki, A.; Beachey, D. J.; Pignol, J. P.
2014-09-01
Permanent seed implant brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose around brachytherapy sources is based on the AAPM TG-43 formalism, which generates the dose in a homogeneous water medium. Recently, AAPM TG-186 emphasized the importance of accounting for tissue heterogeneities. We have previously reported on a methodology where the absorbed dose in tissue can be obtained by multiplying the dose, calculated by the TG-43 formalism, by an inhomogeneity correction factor (ICF). In this work we make use of dual energy CT (DECT) images to extract ICF parameters. The advantage of DECT over conventional CT is that it eliminates the need for tissue segmentation as well as assignment of population based atomic compositions. DECT images of a heterogeneous phantom were acquired and the dose was calculated using both TG-43 and TG-43 × \\text{ICF} formalisms. The results were compared to experimental measurements using Gafchromic films in the mid-plane of the phantom. For a seed implant configuration of 8 seeds spaced 1.5 cm apart in a cubic structure, the gamma passing score for 2%/2 mm criteria improved from 40.8% to 90.5% when ICF was applied to TG-43 dose distributions.
Contaminant Detection in Heterogeneous Aquifers: Sampling Frequency and Number of Monitoring Wells
NASA Astrophysics Data System (ADS)
Paleologos, E.; Papapetridis, K.
2012-04-01
A Monte Carlo stochastic model was developed to simulate contaminant transport from an instantaneous source into a heterogeneous, two-dimensional aquifer in order to evaluate the effectiveness of contaminant detection by a network of monitoring wells. Successful detection is influenced by many uncertainty factors, where the heterogeneity of the geologic environment and inherent contamination dispersion into the geologic medium are the most important. Additional uncertainty arises from the lack of information about the quantity and nature of the contaminants, the time of leakage, the number and location of the contamination sources and monitoring wells, as well as the frequency of sampling. The heterogeneity of the geologic environment was addressed through the hydraulic conductivity, which was simulated as a log-normal, stationary, second order, isotropic stochastic process. The second source of uncertainty arises from the way a pollutant is transported into the subsurface heterogeneous environment. The particle tracking method based on the 'random walk' approach was adopted to simulate a plume's advective and dispersive movement. In this study a conservative and fully water soluble contaminant was assumed, considering different cases of initially released quantities, single or dual random sources inside landfill's boundaries and different facility's dimensions. Several numerical experiments were conducted in order to determine the detection probabilities Pd achieved by monitoring networks, to evaluate the effectiveness of various sampling frequencies and to calculate the contaminated groundwater areas. It was shown that detection decreases as heterogeneity increases. Monitoring with 20 wells provides high detection, while 3 wells result in four out of five contamination cases to remain undetected. For fixed heterogeneity, for each well arrangement, Pd increases up to a certain value with increasing transverse dispersion coefficient and then it decreases. The
Characterization of Paper Heterogeneity
NASA Astrophysics Data System (ADS)
Considine, John M.
Paper and paperboard are the most widely-used green materials in the world because they are renewable, recyclable, reusable, and compostable. Continued and expanded use of these materials and their potential use in new products requires a comprehensive understanding of the variability of their mechanical properties. This work develops new methods to characterize the mechanical properties of heterogeneous materials through a combination of techniques in experimental mechanics, materials science and numerical analysis. Current methods to analyze heterogeneous materials focus on crystalline materials or polymer-crystalline composites, where material boundaries are usually distinct. This work creates a methodology to analyze small, continuously-varying stiffness gradients in 100% polymer systems and is especially relevant to paper materials where factors influencing heterogeneity include local mass, fiber orientation, individual pulp fiber properties, local density, and drying restraint. A unique approach was used to understand the effect of heterogeneity on paper tensile strength. Additional variation was intentionally introduced, in the form of different size holes, and their effect on strength was measured. By modifying two strength criteria, an estimate of strength in the absence of heterogeneity was determined. In order to characterize stiffness heterogeneity, a novel load fixture was developed to excite full-field normal and shear strains for anisotropic stiffness determination. Surface strains were measured with digital image correlation and were analyzed with the VFM (Virtual Fields Method). This approach led to VFM-identified stiffnesses that were similar to values determined by conventional tests. The load fixture and VFM analyses were used to measure local stiffness and local stiffness variation on heterogeneous anisotropic materials. The approach was validated on simulated heterogeneous materials and was applied experimentally to three different paperboards
Anisotropy and Heterogeneity Interaction in Shear Zones
NASA Astrophysics Data System (ADS)
Dabrowski, M.; Schmid, D. W.
2009-04-01
Rocks are heterogeneous on many different scales and deformation may introduce a coexistence of heterogeneity and anisotropy in shear zones. A competent inclusion embedded in a laminated matrix is a typical example. Indisputably, the presence of a mechanical heterogeneity leads to a flow perturbation and consequently to a deflection of the lamination in its vicinity. Assuming a passive response of the matrix phase, the pattern formation around rigid objects has been modeled in two and three dimensions using analytical solutions. Yet, the laminas may be mechanically distinct, leading to an effectively anisotropic rheology of the matrix. The feedback of an evolving matrix structure on the inclusion motion cannot be precluded in this case. In our study elliptical inclusions of varying aspect ratios are embedded in a laminated linear viscous host and subject to a large simple shear deformation in finite element numerical simulations. Increasing the viscosity ratio of the weak and strong lamina significantly changes the pattern characteristics in the matrix. The structural evolution around an inclusion proves to have a major impact on the inclusion motion, leading to the stabilization of elongated inclusions at antithetic orientations. We provide a comparison of two different modeling approaches. In the first approach discrete layers are introduced in the matrix and the large strain evolution of individual minute layers is resolved. Next, the matrix is modeled as an anisotropic medium using an evolving director field that locally describes the anisotropy direction. The length scale of layering can be restored in this model using the micropolar medium formulation.
Green's Function Retrieval and Marchenko Imaging in a Dissipative Acoustic Medium
NASA Astrophysics Data System (ADS)
Slob, Evert
2016-04-01
Single-sided Marchenko equations for Green's function construction and imaging relate the measured reflection response of a lossless heterogeneous medium to an acoustic wave field inside this medium. I derive two sets of single-sided Marchenko equations for the same purpose, each in a heterogeneous medium, with one medium being dissipative and the other a corresponding medium with negative dissipation. Double-sided scattering data of the dissipative medium are required as input to compute the surface reflection response in the corresponding medium with negative dissipation. I show that each set of single-sided Marchenko equations leads to Green's functions with a virtual receiver inside the medium: one exists inside the dissipative medium and one in the medium with negative dissipation. This forms the basis of imaging inside a dissipative heterogeneous medium. I relate the Green's functions to the reflection response inside each medium, from which the image can be constructed. I illustrate the method with a one-dimensional example that shows the image quality. The method has a potentially wide range of imaging applications where the material under test is accessible from two sides.
Simple heterogeneity parametrization for sea surface temperature and chlorophyll
NASA Astrophysics Data System (ADS)
Skákala, Jozef; Smyth, Timothy J.
2016-06-01
Using satellite maps this paper offers a complex analysis of chlorophyll & SST heterogeneity in the shelf seas around the southwest of the UK. The heterogeneity scaling follows a simple power law and is consequently parametrized by two parameters. It is shown that in most cases these two parameters vary only relatively little with time. The paper offers a detailed comparison of field heterogeneity between different regions. How much heterogeneity is in each region preserved in the annual median data is also determined. The paper explicitly demonstrates how one can use these results to calculate representative measurement area for in situ networks.
NASA Technical Reports Server (NTRS)
Kinnison, Douglas E.; Wuebbles, Donald J.
1994-01-01
Preliminary calculations suggest that heterogeneous reactions are important in calculating the impact on ozone from emissions of trace gases from aircraft fleets. In this study, three heterogeneous chemical processes that occur on background sulfuric acid aerosols are included and their effects on O3, NO(x), Cl(x), HCl, N2O5, ClONO2 are calculated.
Transmissivity of a heterogeneous formation
NASA Astrophysics Data System (ADS)
Dykaar, Bruce B.; Kitanidis, Peter K.
1993-04-01
The objective of this paper is to derive the transmissivity of an equivalent homogeneous medium having the same macroscopic flow behavior as the actual heterogeneous formation. We apply generalized Taylor-Ans moment analysis in order to determine the phenomenological coefficient of transmissivity for the case of saturated flow confined in a heterogeneous permeable formation with variable thickness. The generalized Taylor-Aris moment analysis yields a two-step procedure for determining the constant two-dimensional transmissivity tensor from the three-dimensional spatially variable conductivity tensor: solve a flow problem and then perform an integration. For the special case that the conductivity is locally isotropic and the impermeable confining surfaces are parallel, the equations governing transmissivity are discretized using a pseudospectral Fourier-Galerkin scheme. The resultant system of linear algebraic equations is solved efficiently, using preconditioned conjugate gradients, in order Nt In (Nt) operations, where Nt is the number of spatial discretization points. The numerical method is used in several examples to compute the transmissivity of lognormally distributed hydraulic conductivity, and the results are compared with the transmissivity found using the usual depth-averaging approach and another method suggested in the literature. The numerical results show that the averaging volume required to obtain an effective value of transmissivity is about 10 horizontal integral scales. When the flow field has a significant three-dimensional character, the standard method of finding transmissivities by depth averaging can lead to significant errors in the prediction of global scale flows. It is shown that depth averaging consistently overestimates transmissivities. An example illustrates how in the case of tilted strata, anisotropic transmissivities arise and how the degree of transmissivity anisotropy depends on the angle of the dip and the horizontal to
National Institute of Standards and Technology Data Gateway
SRD 166 MEMS Calculator (Web, free access) This MEMS Calculator determines the following thin film properties from data taken with an optical interferometer or comparable instrument: a) residual strain from fixed-fixed beams, b) strain gradient from cantilevers, c) step heights or thicknesses from step-height test structures, and d) in-plane lengths or deflections. Then, residual stress and stress gradient calculations can be made after an optical vibrometer or comparable instrument is used to obtain Young's modulus from resonating cantilevers or fixed-fixed beams. In addition, wafer bond strength is determined from micro-chevron test structures using a material test machine.
Ring-closing metathesis in aqueous micellar medium.
Laville, Lionel; Charnay, Clarence; Lamaty, Frédéric; Martinez, Jean; Colacino, Evelina
2012-01-16
Underwater exploration: The ring-closing metathesis of N,N-diallyltosylamine (DATs) and diallyldiethyl malonate has been studied in aqueous micellar medium, at room temperature, in the presence of four different gemini cationic surfactants and various ruthenium catalysts. For the first time, the adsorption mechanisms and the reaction steps involved in this heterogeneous catalytic process were elucidated.
NASA Astrophysics Data System (ADS)
Pruhs, Kirk
A particularly important emergent technology is heterogeneous processors (or cores), which many computer architects believe will be the dominant architectural design in the future. The main advantage of a heterogeneous architecture, relative to an architecture of identical processors, is that it allows for the inclusion of processors whose design is specialized for particular types of jobs, and for jobs to be assigned to a processor best suited for that job. Most notably, it is envisioned that these heterogeneous architectures will consist of a small number of high-power high-performance processors for critical jobs, and a larger number of lower-power lower-performance processors for less critical jobs. Naturally, the lower-power processors would be more energy efficient in terms of the computation performed per unit of energy expended, and would generate less heat per unit of computation. For a given area and power budget, heterogeneous designs can give significantly better performance for standard workloads. Moreover, even processors that were designed to be homogeneous, are increasingly likely to be heterogeneous at run time: the dominant underlying cause is the increasing variability in the fabrication process as the feature size is scaled down (although run time faults will also play a role). Since manufacturing yields would be unacceptably low if every processor/core was required to be perfect, and since there would be significant performance loss from derating the entire chip to the functioning of the least functional processor (which is what would be required in order to attain processor homogeneity), some processor heterogeneity seems inevitable in chips with many processors/cores.
Shock Initiation of Heterogeneous Explosives
Reaugh, J E
2004-05-10
The fundamental picture that shock initiation in heterogeneous explosives is caused by the linking of hot spots formed at inhomogeneities was put forward by several researchers in the 1950's and 1960's, and more recently. Our work uses the computer hardware and software developed in the Advanced Simulation and Computing (ASC) program of the U.S. Department of Energy to explicitly include heterogeneities at the scale of the explosive grains and to calculate the consequences of realistic although approximate models of explosive behavior. Our simulations are performed with ALE-3D, a three-dimensional, elastic-plastic-hydrodynamic Arbitrary Lagrange-Euler finite-difference program, which includes chemical kinetics and heat transfer, and which is under development at this laboratory. We developed the parameter values for a reactive-flow model to describe the non-ideal detonation behavior of an HMX-based explosive from the results of grain-scale simulations. In doing so, we reduced the number of free parameters that are inferred from comparison with experiment to a single one - the characteristic defect dimension. We also performed simulations of the run to detonation in small volumes of explosive. These simulations illustrate the development of the reaction zone and the acceleration of the shock front as the flame fronts start from hot spots, grow, and interact behind the shock front. In this way, our grain-scale simulations can also connect to continuum experiments directly.
ERIC Educational Resources Information Center
Chenery, Gordon
1991-01-01
Uses chaos theory to investigate the nonlinear phenomenon of population growth fluctuation. Illustrates the use of computers and computer programs to make calculations in a nonlinear difference equation system. (MDH)
Wetting of a Chemically Heterogeneous Surface
Frink, L.J.D.; Salinger, A.G.
1998-11-20
Theories for inhomogeneous fluids have focused in recent years on wetting, capillary conden- sation, and solvation forces for model systems where the surface(s) is(are) smooth homogeneous parallel plates, cylinders, or spherical drops. Unfortunately natural systems are more likely to be hetaogeneous both in surt%ce shape and surface chemistry. In this paper we discuss the conse- quences of chemical heterogeneity on wetting. Specifically, a 2-dimensional implementation of a nonlocal density functional theory is solved for a striped surface model. Both the strength and range of the heterogeneity are varied. Contact angles are calculated, and phase transitions (both the wetting transition and a local layering transition) are located. The wetting properties of the surface ase shown to be strongly dependent on the nature of the surface heterogeneity. In addition highly ordered nanoscopic phases are found, and the operational limits for formation of ordered or crystalline phases of nanoscopic extent are discussed.
Heterogeneous Catalytic Chemistry by Example of Industrial Applications
ERIC Educational Resources Information Center
Heveling, Josef
2012-01-01
Worldwide, more than 85% of all chemical products are manufactured with the help of catalysts. Virtually all transition metals of the periodic table are active as catalysts or catalyst promoters. Catalysts are divided into homogeneous catalysts, which are soluble in the reaction medium, and heterogeneous catalysts, which remain in the solid state.…
Heterogeneous waste processing
Vanderberg, Laura A.; Sauer, Nancy N.; Brainard, James R.; Foreman, Trudi M.; Hanners, John L.
2000-01-01
A combination of treatment methods are provided for treatment of heterogeneous waste including: (1) treatment for any organic compounds present; (2) removal of metals from the waste; and, (3) bulk volume reduction, with at least two of the three treatment methods employed and all three treatment methods emplyed where suitable.
Lenormand, R.; Thiele, M.R.
1997-08-01
The paper describes the method and presents preliminary results for the calculation of homogenized relative permeabilities
Jiang, Xu; Deng, Yong; Luo, Zhaoyang; Wang, Kan; Lian, Lichao; Yang, Xiaoquan; Meglinski, Igor; Luo, Qingming
2014-12-29
The path-history-based fluorescence Monte Carlo method used for fluorescence tomography imaging reconstruction has attracted increasing attention. In this paper, we first validate the standard fluorescence Monte Carlo (sfMC) method by experimenting with a cylindrical phantom. Then, we describe a path-history-based decoupled fluorescence Monte Carlo (dfMC) method, analyze different perturbation fluorescence Monte Carlo (pfMC) methods, and compare the calculation accuracy and computational efficiency of the dfMC and pfMC methods using the sfMC method as a reference. The results show that the dfMC method is more accurate and efficient than the pfMC method in heterogeneous medium.
NASA Technical Reports Server (NTRS)
Dede, Christopher J.
1990-01-01
Claims and rebuttals that hypermedia (the associative, nonlinear interconnection of multimedia materials) is a fundamentally innovative means of thinking and communicating are described. This representational architecture has many advantages that make it a major advance over other media; however, it also has several intrinsic problems that severly limits its effectiveness as a medium. These advantages and limits in applications are discussed.
NASA Technical Reports Server (NTRS)
Gange, Robert Allen (Inventor)
1977-01-01
A holographic recording medium comprising a conductive substrate, a photoconductive layer and an electrically alterable layer of a linear, low molecular weight hydrocarbon polymer has improved fatigue resistance. An acrylic barrier layer can be interposed between the photoconductive and electrically alterable layers.
Gravitational lensing in plasmic medium
Bisnovatyi-Kogan, G. S. Tsupko, O. Yu.
2015-07-15
The influence of plasma on different effects of gravitational lensing is reviewed. Using the Hamiltonian approach for geometrical optics in a medium in the presence of gravity, an exact formula for the photon deflection angle by a black hole (or another body with a Schwarzschild metric) embedded in plasma with a spherically symmetric density distribution is derived. The deflection angle in this case is determined by the mutual combination of different factors: gravity, dispersion, and refraction. While the effects of deflection by the gravity in vacuum and the refractive deflection in a nonhomogeneous medium are well known, the new effect is that, in the case of a homogeneous plasma, in the absence of refractive deflection, the gravitational deflection differs from the vacuum deflection and depends on the photon frequency. In the presence of a plasma nonhomogeneity, the chromatic refractive deflection also occurs, so the presence of plasma always makes gravitational lensing chromatic. In particular, the presence of plasma leads to different angular positions of the same image if it is observed at different wavelengths. It is discussed in detail how to apply the presented formulas for the calculation of the deflection angle in different situations. Gravitational lensing in plasma beyond the weak deflection approximation is also considered.
Gravitational lensing in plasmic medium
NASA Astrophysics Data System (ADS)
Bisnovatyi-Kogan, G. S.; Tsupko, O. Yu.
2015-07-01
The influence of plasma on different effects of gravitational lensing is reviewed. Using the Hamiltonian approach for geometrical optics in a medium in the presence of gravity, an exact formula for the photon deflection angle by a black hole (or another body with a Schwarzschild metric) embedded in plasma with a spherically symmetric density distribution is derived. The deflection angle in this case is determined by the mutual combination of different factors: gravity, dispersion, and refraction. While the effects of deflection by the gravity in vacuum and the refractive deflection in a nonhomogeneous medium are well known, the new effect is that, in the case of a homogeneous plasma, in the absence of refractive deflection, the gravitational deflection differs from the vacuum deflection and depends on the photon frequency. In the presence of a plasma nonhomogeneity, the chromatic refractive deflection also occurs, so the presence of plasma always makes gravitational lensing chromatic. In particular, the presence of plasma leads to different angular positions of the same image if it is observed at different wavelengths. It is discussed in detail how to apply the presented formulas for the calculation of the deflection angle in different situations. Gravitational lensing in plasma beyond the weak deflection approximation is also considered.
NASA Astrophysics Data System (ADS)
Masuda, Naoki; Gibert, N.; Redner, S.
2010-07-01
We introduce the heterogeneous voter model (HVM), in which each agent has its own intrinsic rate to change state, reflective of the heterogeneity of real people, and the partisan voter model (PVM), in which each agent has an innate and fixed preference for one of two possible opinion states. For the HVM, the time until consensus is reached is much longer than in the classic voter model. For the PVM in the mean-field limit, a population evolves to a preference-based state, where each agent tends to be aligned with its internal preference. For finite populations, discrete fluctuations ultimately lead to consensus being reached in a time that scales exponentially with population size.
Atmospheric Heterogeneous Stereochemistry
NASA Astrophysics Data System (ADS)
Stokes, G. Y.; Buchbinder, A. M.; Geiger, F. M.
2009-12-01
This paper addresses the timescale and mechanism of heterogeneous interactions of laboratory models of organic-coated mineral dust and ozone. We are particularly interested in investigating the role of stereochemistry in heterogeneous oxidation reactions involving chiral biogenic VOCs. Using the surface-specific nonlinear optical spectroscopy, sum frequency generation, we tracked terpene diastereomers during exposure to 10^11 to 10^13 molecules of ozone per cm^3 in 1 atm helium to model ozone-limited and ozone-rich tropospheric conditions. Our kinetic data indicate that the diastereomers which orient their reactive C=C double bonds towards the gas phase exhibit heterogeneous ozonolysis rate constants that are two times faster than diastereomers that orient their C=C double bonds away from the gas phase. Insofar as our laboratory model studies are representative of real world environments, our studies suggest that the propensity of aerosol particles coated with chiral semivolatile organic compounds to react with ozone may depend on stereochemistry. Implications of these results for chiral markers that would allow for source appointment of anthropogenic versus biogenic carbon emissions will be discussed.
Measuring habitat heterogeneity reveals new insights into bird community composition.
Stirnemann, Ingrid A; Ikin, Karen; Gibbons, Philip; Blanchard, Wade; Lindenmayer, David B
2015-03-01
Fine-scale vegetation cover is a common variable used to explain animal occurrence, but we know less about the effects of fine-scale vegetation heterogeneity. Theoretically, fine-scale vegetation heterogeneity is an important driver of biodiversity because it captures the range of resources available in a given area. In this study we investigated how bird species richness and birds grouped by various ecological traits responded to vegetation cover and heterogeneity. We found that both fine-scale vegetation cover (of tall trees, medium-sized trees and shrubs) and heterogeneity (of tall trees, and shrubs) were important predictors of bird richness, but the direction of the response of bird richness to shrub heterogeneity differed between sites with different proportions of tall tree cover. For example, bird richness increased with shrub heterogeneity in sites with high levels of tall tree cover, but declined in sites with low levels of tall tree cover. Our findings indicated that an increase in vegetation heterogeneity will not always result in an increase in resources and niches, and associated higher species richness. We also found birds grouped by traits responded in a predictable way to vegetation heterogeneity. For example, we found small birds benefited from increased shrub heterogeneity supporting the textual discontinuity hypothesis and non-arboreal (ground or shrub) nesting species were associated with high vegetation cover (low heterogeneity). Our results indicated that focusing solely on increasing vegetation cover (e.g. through restoration) may be detrimental to particular animal groups. Findings from this investigation can help guide habitat management for different functional groups of birds.
Beaulieu, Luc; Carlsson Tedgren, Asa; Carrier, Jean-Francois; and others
2012-10-15
The charge of Task Group 186 (TG-186) is to provide guidance for early adopters of model-based dose calculation algorithms (MBDCAs) for brachytherapy (BT) dose calculations to ensure practice uniformity. Contrary to external beam radiotherapy, heterogeneity correction algorithms have only recently been made available to the BT community. Yet, BT dose calculation accuracy is highly dependent on scatter conditions and photoelectric effect cross-sections relative to water. In specific situations, differences between the current water-based BT dose calculation formalism (TG-43) and MBDCAs can lead to differences in calculated doses exceeding a factor of 10. MBDCAs raise three major issues that are not addressed by current guidance documents: (1) MBDCA calculated doses are sensitive to the dose specification medium, resulting in energy-dependent differences between dose calculated to water in a homogeneous water geometry (TG-43), dose calculated to the local medium in the heterogeneous medium, and the intermediate scenario of dose calculated to a small volume of water in the heterogeneous medium. (2) MBDCA doses are sensitive to voxel-by-voxel interaction cross sections. Neither conventional single-energy CT nor ICRU/ICRP tissue composition compilations provide useful guidance for the task of assigning interaction cross sections to each voxel. (3) Since each patient-source-applicator combination is unique, having reference data for each possible combination to benchmark MBDCAs is an impractical strategy. Hence, a new commissioning process is required. TG-186 addresses in detail the above issues through the literature review and provides explicit recommendations based on the current state of knowledge. TG-43-based dose prescription and dose calculation remain in effect, with MBDCA dose reporting performed in parallel when available. In using MBDCAs, it is recommended that the radiation transport should be performed in the heterogeneous medium and, at minimum, the dose to
Shock and Rarefaction Waves in a Heterogeneous Mantle
NASA Astrophysics Data System (ADS)
Jordan, J.; Hesse, M. A.
2012-12-01
We explore the effect of heterogeneities on partial melting and melt migration during active upwelling in the Earth's mantle. We have constructed simple, explicit nonlinear models in one dimension to examine heterogeneity and its dynamic affects on porosity, temperature and the magnesium number in a partially molten, porous medium comprised of olivine. The composition of the melt and solid are defined by a closed, binary phase diagram for a simplified, two-component olivine system. The two-component solid solution is represented by a phase loop where concentrations 0 and 1 to correspond to fayalite and forsterite, respectively. For analysis, we examine an advective system with a Riemann initial condition. Chromatographic tools and theory have primarily been used to track large, rare earth elements as tracers. In our case, we employ these theoretical tools to highlight the importance of the magnesium number, enthalpy and overall heterogeneity in the dynamics of melt migration. We calculate the eigenvectors and eigenvalues in the concentration-enthalpy space in order to glean the characteristics of the waves emerging the Riemann step. Analysis on Riemann problems of this nature shows us that the composition-enthalpy waves can be represented by self-similar solutions. The eigenvalues of the composition-enthalpy system represent the characteristic wave propagation speeds of the compositions and enthalpy through the domain. Furthermore, the corresponding eigenvectors are the directions of variation, or ``pathways," in concentration-enthalpy space that the characteristic waves follow. In the two-component system, the Riemann problem yields two waves connected by an intermediate concentration-enthalpy state determined by the intersections of the integral curves of the eigenvectors emanating from both the initial and boundary states. The first wave, ``slow path," and second wave, ``fast path," follow the aformentioned pathways set by the eigenvectors. The slow path wave
Wang, Zhengwen; van Kleunen, Mark; During, Heinjo J.; Werger, Marinus J. A.
2013-01-01
Background Plastic root-foraging responses have been widely recognized as an important strategy for plants to explore heterogeneously distributed resources. However, the benefits and costs of root foraging have received little attention. Methodology/Principal Findings In a greenhouse experiment, we grew pairs of connected ramets of 22 genotypes of the stoloniferous plant Potentilla reptans in paired pots, between which the contrast in nutrient availability was set as null, medium and high, but with the total nutrient amount kept the same. We calculated root-foraging intensity of each individual ramet pair as the difference in root mass between paired ramets divided by the total root mass. For each genotype, we then calculated root-foraging ability as the slope of the regression of root-foraging intensity against patch contrast. For all genotypes, root-foraging intensity increased with patch contrast and the total biomass and number of offspring ramets were lowest at high patch contrast. Among genotypes, root-foraging intensity was positively related to production of offspring ramets and biomass in the high patch-contrast treatment, which indicates an evolutionary benefit of root foraging in heterogeneous environments. However, we found no significant evidence that the ability of plastic foraging imposes costs under homogeneous conditions (i.e. when foraging is not needed). Conclusions/Significance Our results show that plants of P. reptans adjust their root-foraging intensity according to patch contrast. Moreover, the results show that the root foraging has an evolutionary advantage in heterogeneous environments, while costs of having the ability of plastic root foraging were absent or very small. PMID:23472211
Soft random solids and their heterogeneous elasticity.
Mao, Xiaoming; Goldbart, Paul M; Xing, Xiangjun; Zippelius, Annette
2009-09-01
Spatial heterogeneity in the elastic properties of soft random solids is examined via vulcanization theory. The spatial heterogeneity in the structure of soft random solids is a result of the fluctuations locked-in at their synthesis, which also brings heterogeneity in their elastic properties. Vulcanization theory studies semimicroscopic models of random-solid-forming systems and applies replica field theory to deal with their quenched disorder and thermal fluctuations. The elastic deformations of soft random solids are argued to be described by the Goldstone sector of fluctuations contained in vulcanization theory, associated with a subtle form of spontaneous symmetry breaking that is associated with the liquid-to-random-solid transition. The resulting free energy of this Goldstone sector can be reinterpreted as arising from a phenomenological description of an elastic medium with quenched disorder. Through this comparison, we arrive at the statistics of the quenched disorder of the elasticity of soft random solids in terms of residual stress and Lamé-coefficient fields. In particular, there are large residual stresses in the equilibrium reference state, and the disorder correlators involving the residual stress are found to be long ranged and governed by a universal parameter that also gives the mean shear modulus. PMID:19905095
Soft random solids and their heterogeneous elasticity
NASA Astrophysics Data System (ADS)
Mao, Xiaoming; Goldbart, Paul M.; Xing, Xiangjun; Zippelius, Annette
2009-09-01
Spatial heterogeneity in the elastic properties of soft random solids is examined via vulcanization theory. The spatial heterogeneity in the structure of soft random solids is a result of the fluctuations locked-in at their synthesis, which also brings heterogeneity in their elastic properties. Vulcanization theory studies semimicroscopic models of random-solid-forming systems and applies replica field theory to deal with their quenched disorder and thermal fluctuations. The elastic deformations of soft random solids are argued to be described by the Goldstone sector of fluctuations contained in vulcanization theory, associated with a subtle form of spontaneous symmetry breaking that is associated with the liquid-to-random-solid transition. The resulting free energy of this Goldstone sector can be reinterpreted as arising from a phenomenological description of an elastic medium with quenched disorder. Through this comparison, we arrive at the statistics of the quenched disorder of the elasticity of soft random solids in terms of residual stress and Lamé-coefficient fields. In particular, there are large residual stresses in the equilibrium reference state, and the disorder correlators involving the residual stress are found to be long ranged and governed by a universal parameter that also gives the mean shear modulus.
Soil Particle Heterogeneity Affects the Growth of a Rhizomatous Wetland Plant
Xue, Wei; Peng, Yi-Ke; Zhang, Ming-Xiang; Yu, Fei-Hai
2013-01-01
Soil is commonly composed of particles of different sizes, and soil particle size may greatly affect the growth of plants because it affects soil physical and chemical properties. However, no study has tested the effects of soil particle heterogeneity on the growth of clonal plants. We conducted a greenhouse experiment in which individual ramets of the wetland plant Bolboschoenus planiculmis were grown in three homogeneous soil treatments with uniformly sized quartz particles (small: 0.75 mm, medium: 1.5 mm, or large: 3 mm), one homogeneous treatment with an even mixture of large and medium particles, and two heterogeneous treatments consisting of 16 or 4 patches of large and medium particles. Biomass, ramet number, rhizome length and spacer length were significantly greater in the treatment with only medium particles than in the one with only large particles. Biomass, ramet number, rhizome length and tuber number in the patchy treatments were greater in patches of medium than of large particles; this difference was more pronounced when patches were small than when they were large. Soil particle size and soil particle heterogeneity can greatly affect the growth of clonal plants. Thus, studies to test the effects of soil heterogeneity on clonal plants should distinguish the effects of nutrient heterogeneity from those of particle heterogeneity. PMID:23936110
Liquid chromatographic extraction medium
Horwitz, E. Philip; Dietz, Mark L.
1994-01-01
A method and apparatus for extracting strontium and technetium values from biological, industrial and environmental sample solutions using a chromatographic column is described. An extractant medium for the column is prepared by generating a solution of a diluent containing a Crown ether and dispersing the solution on a resin substrate material. The sample solution is highly acidic and is introduced directed to the chromatographic column and strontium or technetium is eluted using deionized water.
Liquid chromatographic extraction medium
Horwitz, E.P.; Dietz, M.L.
1994-09-13
A method and apparatus are disclosed for extracting strontium and technetium values from biological, industrial and environmental sample solutions using a chromatographic column. An extractant medium for the column is prepared by generating a solution of a diluent containing a Crown ether and dispersing the solution on a resin substrate material. The sample solution is highly acidic and is introduced directed to the chromatographic column and strontium or technetium is eluted using deionized water. 1 fig.
Hunter, Charles H.
2000-05-22
This software calculates a Wet Bulb Globe Temperature (WBGT) using standard measurements from a meteorological station. WBGT is used by Industrial Hygenists (IH) to determine heat stress potential to outdoor workers. Through the mid 1990''s, SRS technicians were dispatched several times daily to measure WBGT with a custom hand held instrument and results were dessiminated via telephone. Due to workforce reductions, the WSRC IH Department asked for the development of an automated method to simulate the WBGT measurement using existing real time data from the Atmospheric Technologies Group''s meteorological monitoring network.
2000-05-22
This software calculates a Wet Bulb Globe Temperature (WBGT) using standard measurements from a meteorological station. WBGT is used by Industrial Hygenists (IH) to determine heat stress potential to outdoor workers. Through the mid 1990''s, SRS technicians were dispatched several times daily to measure WBGT with a custom hand held instrument and results were dessiminated via telephone. Due to workforce reductions, the WSRC IH Department asked for the development of an automated method to simulatemore » the WBGT measurement using existing real time data from the Atmospheric Technologies Group''s meteorological monitoring network.« less
Positron annihilation in the interstellar medium
NASA Technical Reports Server (NTRS)
Guessoum, Nidhal; Ramaty, Reuven; Lingenfelter, Richard E.
1991-01-01
Positronium formation and annihilation are studied in a model for the interstellar medium consisting of cold cloud cores, warm partially ionized cloud envelopes, and hot intercloud gas. The gamma-ray spectra resulting from positron annihilation in these components of the interstellar medium are calculated. The spectra from the individual components are then combined, using two limiting assumptions for the propagation of the positrons, namely, that the positrons propagate freely throughout the interstellar medium, and that the positrons are excluded from the cold cloud cores. In the first case, the bulk of the positrons annihilate in the cloud cores and the annihilation line exhibits broad wings resulting from the annihilation of positronium formed by charge exchange in flight. In the second case, the positrons annihilate mainly in the warm envelopes, and the line wings are suppressed.
Intratumor Heterogeneity in Breast Cancer.
Beca, Francisco; Polyak, Kornelia
2016-01-01
Intratumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. Both genetic and epigenetic sources of intratumor heterogeneity are well recognized and several technologies have been developed for their characterization. With the technological advances in recent years, investigators are now elucidating intratumor heterogeneity at the single cell level and in situ. However, translating the accumulated knowledge about intratumor heterogeneity to clinical practice has been slow. We are certain that better understanding of the composition and evolution of tumors during disease progression and treatment will improve cancer diagnosis and the design of therapies. Here we review some of the most important considerations related to intratumor heterogeneity. We discuss both genetic and epigenetic sources of intratumor heterogeneity and review experimental approaches that are commonly used to quantify it. We also discuss the impact of intratumor heterogeneity on cancer diagnosis and treatment and share our perspectives on the future of this field. PMID:26987535
Yan, Jun-xia; Liang, Ya-nan; Li, Hong-jian; Li, Jun-jian
2015-12-01
Based on observations of soil respiration rate (Rs) and both biotic and abiotic factors in Pangquangou Nature Reserve at three sampling scales (4, 2, and 1 m), we studied the spatial heterogeneity of Rs and the factors, and analyzed impacts of soil temperature at the 5, 10 and 15 cm depth (T5, T10, T15), soil moisture over the depth of 0-10 cm (Ws), and soil total nitrogen (N), soil total organic carbon (C), ratio of carbon and nitrogen (C/N), soil total sulfur (S), litter fall mass (Lw) and litter fall moisture (Lm) on the spatial heterogeneity of Rs, respectively. We also calculated the minimum sampling number of all the factors at different confidence levels and under the responding estimation accuracy. The results showed that: (1) the spatial heterogeneity of C/N at 4 m sampling scale, Ws at 2 m sampling scale and T10, T15 at 1 m sampling scale had low variability, while the spatial variation of Rs and other related factors had medium variability. Coefficients of variation of Rs, C/N and S decreased with the increase of the sampling scales, but those of N, C, Ws, T₅, T₁₀, T₁₅, Lw and Lm showed contrary trend; (2) the spatial autocorrelation of Rs, Ws, T₅, T₁₀, T₁₅, Lw and Lm decreased with the decrease of sampling scales but the spatial autocorrelation of C, N, C/N increased with the decrease of sampling scales, and the spatial autocorrelation of S decreased with the decrease of the sampling scales at initial stage and then increased; (3) the key factors that influenced the spatial heterogeneity of soil respiration were different at different sampling scales. Soil temperature was the key factor influencing the spatial heterogeneity of Rs at a larger scale. However, at a smaller scale, the spatial heterogeneity of Rs was influenced by C, Lw and Lm; (4) the minimum sampling number for soil respiration measurement and its influencing factors reduced greatly with the decrease of confidence level and responding estimation accuracy. The sampling
Pore scale heterogeneity in the mineral distribution and surface area of porous rocks
NASA Astrophysics Data System (ADS)
Lai, Peter; Moulton, Kevin; Krevor, Samuel
2014-05-01
There are long-standing challenges in characterizing reactive transport in porous media at scales larger than individual pores. This hampers the prediction of the field-scale impact of geochemical processes on fluid flow [1]. This is a source of uncertainty for carbon dioxide injection, which results in a reactive fluid-rock system, particularly in carbonate rock reservoirs. A potential cause is the inability of the continuum approach to incorporate the impact of heterogeneity in pore-scale reaction rates. This results in part from pore-scale heterogeneities in surface area of reactive minerals [2,3]. The objective of this study was to quantify heterogeneity in reactive surface and observe the extent of its non-normal character. In this study we describe our work in using micron-scale x-ray imaging and other spectroscopic techniques for the purpose of describing the statistical distribution of reactive surface area within a porous medium, and identifying specific mineral phases and their distribution in 3-dimensions. Using in-house image processing techniques and auxilary charactersation with thin section, electron microscope and spectroscopic techniques we quantified the surface area of each mineral phase in the x-ray CT images. This quantification was validated against nitrogen BET surface area and backscattered electron imaging measurements of the CT-imaged samples. Distributions in reactive surface area for each mineral phase were constructed by calculating surface areas in thousands of randomly selected subvolume images of the total sample, each normalized to the pore volume in that image. In all samples, there is little correlation between the reactive surface area fraction and the volumetric fraction of a mineral in a bulk rock. Berea sandstone was far less heterogeneous and has a characteristic pore size at which a surface area distribution may be used to quantify heterogeneity. In carbonates, heterogeneity is more complex and surface area must be
Yan, Jun-xia; Liang, Ya-nan; Li, Hong-jian; Li, Jun-jian
2015-12-01
Based on observations of soil respiration rate (Rs) and both biotic and abiotic factors in Pangquangou Nature Reserve at three sampling scales (4, 2, and 1 m), we studied the spatial heterogeneity of Rs and the factors, and analyzed impacts of soil temperature at the 5, 10 and 15 cm depth (T5, T10, T15), soil moisture over the depth of 0-10 cm (Ws), and soil total nitrogen (N), soil total organic carbon (C), ratio of carbon and nitrogen (C/N), soil total sulfur (S), litter fall mass (Lw) and litter fall moisture (Lm) on the spatial heterogeneity of Rs, respectively. We also calculated the minimum sampling number of all the factors at different confidence levels and under the responding estimation accuracy. The results showed that: (1) the spatial heterogeneity of C/N at 4 m sampling scale, Ws at 2 m sampling scale and T10, T15 at 1 m sampling scale had low variability, while the spatial variation of Rs and other related factors had medium variability. Coefficients of variation of Rs, C/N and S decreased with the increase of the sampling scales, but those of N, C, Ws, T₅, T₁₀, T₁₅, Lw and Lm showed contrary trend; (2) the spatial autocorrelation of Rs, Ws, T₅, T₁₀, T₁₅, Lw and Lm decreased with the decrease of sampling scales but the spatial autocorrelation of C, N, C/N increased with the decrease of sampling scales, and the spatial autocorrelation of S decreased with the decrease of the sampling scales at initial stage and then increased; (3) the key factors that influenced the spatial heterogeneity of soil respiration were different at different sampling scales. Soil temperature was the key factor influencing the spatial heterogeneity of Rs at a larger scale. However, at a smaller scale, the spatial heterogeneity of Rs was influenced by C, Lw and Lm; (4) the minimum sampling number for soil respiration measurement and its influencing factors reduced greatly with the decrease of confidence level and responding estimation accuracy. The sampling
Unravelling mononuclear phagocyte heterogeneity
Geissmann, Frédéric; Gordon, Siamon; Hume, David A.; Mowat, Allan M.; Randolph, Gwendalyn J.
2011-01-01
When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research. PMID:20467425
Seismic waves in a three-dimensional block medium
NASA Astrophysics Data System (ADS)
Aleksandrova, N. I.
2016-08-01
We study numerically the propagation of seismic waves in a three-dimensional block medium. The medium is modelled by a spatial lattice of masses connected by elastic springs and viscous dampers. We study Lamb's problem under a surface point vertical load. The cases of both step and pulse load are considered. The displacements and velocities are calculated for surface masses. The influence of the viscosity of the dampers on the attenuation of perturbations is studied. We compare our numerical results for the block medium with known analytical solutions for the elastic medium.
Heterogeneous broadband network
NASA Astrophysics Data System (ADS)
Dittmann, Lars
1995-11-01
Although the vision for the future Integrated Broadband Communication Network (IBCN) is an all optical network, it is certain that for a long period to come, the network will remain very heterogeneous, with a mixture of different physical media (fiber, coax and twisted pair), transmission systems (PDH, SDH, ADSL) and transport protocols (TCP/IP, AAL/ATM, frame relay). In the current work towards the IBCN, the ATM concept is considered the generic network protocol for both public and private network, with the ability to use different underlying transmission protocols and, through adaptation protocols, provide the appropriate services (old as well as new) to the customer. One of the major difficulties of heterogeneous network is the restriction that is usually given by the lowest common denominator, e.g. in terms of single channel capacity. A possible way to overcome these limitations is by extending the ATM concept with a multilink capability, that allows us to use separate resources as one common. The improved flexibility obtained by this protocol extension further allows a real time optimization of network and call configuration, without any impact on the quality of service seen from the user. This paper describes an example of an ATM based multilink protocol that has been experimentally implemented within the RACE project 'STRATOSPHERIC'. The paper outlines the complexity of introducing an extra network functionality compared with the added value, such as an improved ability to recover an error due to a malfunctioning network component.
NASA Astrophysics Data System (ADS)
Ferlet, Roger
Substantial progress in the field of the Local Interstellar Medium has been largely due to recent launches of space missions, mostly in the UV and X-ray domains, but also to ground-based observations, mainly in high resolution spectroscopy. However, a clear gap seems to remain between the wealth of new data and the theoretical understanding. This paper gives an overview of some observational aspects, with no attempt of completeness or doing justice to all the people involved in the field. As progress rarely evolves in straight paths, we can expect that our present picture of the solar system surroundings is not definitive.
Large epidemic thresholds emerge in heterogeneous networks of heterogeneous nodes
NASA Astrophysics Data System (ADS)
Yang, Hui; Tang, Ming; Gross, Thilo
2015-08-01
One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower the epidemic threshold at which epidemics can invade the system. Network heterogeneity can thus allow diseases with lower transmission probabilities to persist and spread. However, it has been pointed out that networks in which the properties of nodes are intrinsically heterogeneous can be very resilient to disease spreading. Heterogeneity in structure can enhance or diminish the resilience of networks with heterogeneous nodes, depending on the correlations between the topological and intrinsic properties. Here, we consider a plausible scenario where people have intrinsic differences in susceptibility and adapt their social network structure to the presence of the disease. We show that the resilience of networks with heterogeneous connectivity can surpass those of networks with homogeneous connectivity. For epidemiology, this implies that network heterogeneity should not be studied in isolation, it is instead the heterogeneity of infection risk that determines the likelihood of outbreaks.
DENSE MEDIUM CYCLONE OPTIMIZATON
Gerald H. Luttrell; Chris J. Barbee; Peter J. Bethell; Chris J. Wood
2005-06-30
Dense medium cyclones (DMCs) are known to be efficient, high-tonnage devices suitable for upgrading particles in the 50 to 0.5 mm size range. This versatile separator, which uses centrifugal forces to enhance the separation of fine particles that cannot be upgraded in static dense medium separators, can be found in most modern coal plants and in a variety of mineral plants treating iron ore, dolomite, diamonds, potash and lead-zinc ores. Due to the high tonnage, a small increase in DMC efficiency can have a large impact on plant profitability. Unfortunately, the knowledge base required to properly design and operate DMCs has been seriously eroded during the past several decades. In an attempt to correct this problem, a set of engineering tools have been developed to allow producers to improve the efficiency of their DMC circuits. These tools include (1) low-cost density tracers that can be used by plant operators to rapidly assess DMC performance, (2) mathematical process models that can be used to predict the influence of changes in operating and design variables on DMC performance, and (3) an expert advisor system that provides plant operators with a user-friendly interface for evaluating, optimizing and trouble-shooting DMC circuits. The field data required to develop these tools was collected by conducting detailed sampling and evaluation programs at several industrial plant sites. These data were used to demonstrate the technical, economic and environmental benefits that can be realized through the application of these engineering tools.
The lunar seismic tomography and internal heterogeneity
NASA Astrophysics Data System (ADS)
Zhao, N.; Zhu, P.; Yuan, Y.; Zhang, J.
2012-12-01
A seismic tomography is presented to show the internal lateral heterogeneities of moon. The lunar seismic tomography is made from the moonquake arrival-time data acquired by the Apollo program during 1971 to 1977. The seismic records obtained from the four seismic station of Apollo Lunar Surface Experiments Package on the moon. The research target covers the surround of Apollo-12, 14, 15 and 16 landing sites. A preliminary image of three-dimensional P- and S-wave velocity structures of lunar interior have been calculated using hundreds of arrival-times of moonquake events from surface to deep mantle. These results show that some evidences of lateral heterogeneities in the lunar mantle and crust, which implies the existence of complex structure inside the moon.
40 CFR 86.244-94 - Calculations; exhaust emissions.
Code of Federal Regulations, 2012 CFR
2012-07-01
... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.244-94 Calculations; exhaust.... Should NOX measurements be calculated, note that the humidity correction factor is not valid at...
40 CFR 86.244-94 - Calculations; exhaust emissions.
Code of Federal Regulations, 2013 CFR
2013-07-01
... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.244-94 Calculations; exhaust.... Should NOX measurements be calculated, note that the humidity correction factor is not valid at...
Thermodynamic equilibrium at heterogeneous pressure
NASA Astrophysics Data System (ADS)
Vrijmoed, J. C.; Podladchikov, Y. Y.
2015-07-01
Recent advances in metamorphic petrology point out the importance of grain-scale pressure variations in high-temperature metamorphic rocks. Pressure derived from chemical zonation using unconventional geobarometry based on equal chemical potentials fits mechanically feasible pressure variations. Here, a thermodynamic equilibrium method is presented that predicts chemical zoning as a result of pressure variations by Gibbs energy minimization. Equilibrium thermodynamic prediction of the chemical zoning in the case of pressure heterogeneity is done by constrained Gibbs minimization using linear programming techniques. In addition to constraining the system composition, a certain proportion of the system is constrained at a specified pressure. Input pressure variations need to be discretized, and each discrete pressure defines an additional constraint for the minimization. The Gibbs minimization method provides identical results to a geobarometry approach based on chemical potentials, thus validating the inferred pressure gradient. The thermodynamic consistency of the calculation is supported by the similar result obtained from two different approaches. In addition, the method can be used for multi-component, multi-phase systems of which several applications are given. A good fit to natural observations in multi-phase, multi-component systems demonstrates the possibility to explain phase assemblages and zoning by spatial pressure variations at equilibrium as an alternative to pressure variation in time due to disequilibrium.
Adaptation Driven by Spatial Heterogeneities
NASA Astrophysics Data System (ADS)
Hermsen, Rutger
2011-03-01
Biological evolution and ecology are intimately linked, because the reproductive success or ``fitness'' of an organism depends crucially on its ecosystem. Yet, most models of evolution (or population genetics) consider homogeneous, fixed-size populations subjected to a constant selection pressure. To move one step beyond such ``mean field'' descriptions, we discuss stochastic models of evolution driven by spatial heterogeneity. We imagine a population whose range is limited by a spatially varying environmental parameter, such as a temperature or the concentration of an antibiotic drug. Individuals in the population replicate, die and migrate stochastically. Also, by mutation, they can adapt to the environmental stress and expand their range. This way, adaptation and niche expansion go hand in hand. This mode of evolution is qualitatively different from the usual notion of a population climbing a fitness gradient. We analytically calculate the rate of adaptation by solving a first passage time problem. Interestingly, the joint effects of reproduction, death, mutation and migration result in two distinct parameter regimes depending on the relative time scales of mutation and migration. We argue that the proposed scenario may be relevant for the rapid evolution of antibiotic resistance. This work was supported by the Center for Theoretical Biological Physics sponsored by the National Science Foundation (NSF) (Grant PHY-0822283).
Heterogeneity in Waardenburg syndrome.
Hageman, M J; Delleman, J W
1977-01-01
Heterogeneity of Waardenburg syndrome is demonstrated in a review of 1,285 patients from the literature and 34 previously unreported patients in five families in the Netherlands. The syndrome seems to consist of two genetically distinct entities that can be differentiated clinically: type I, Waardenburg syndrome with dystopia canthorum; and type II, Waardenburg syndrome without dystopia canthorum. Both types have an autosomal dominant mode of inheritance. The incidence of bilateral deafness in the two types of the syndrome was found in one-fourth with type I and about half of the patients with type II. This difference has important consequences for genetic counseling. Images Fig. 7 Fig. 8 Fig. 9 PMID:331943
Multipartite entanglement in heterogeneous systems
NASA Astrophysics Data System (ADS)
Goyeneche, Dardo; Bielawski, Jakub; Życzkowski, Karol
2016-07-01
Heterogeneous bipartite quantum pure states, composed of two subsystems with a different number of levels, cannot have both reductions maximally mixed. In this work, we demonstrate the existence of a wide range of highly entangled states of heterogeneous multipartite systems consisting of N >2 parties such that every reduction to one and two parties is maximally mixed. Two constructions of generating genuinely multipartite maximally entangled states of heterogeneous systems for an arbitrary number of subsystems are presented. Such states are related to quantum error correction codes over mixed alphabets and mixed orthogonal arrays. Additionally, we show the advantages of considering heterogeneous systems in practical implementations of multipartite steering.
Wang, Pu; Lei, Jing-Pin; Li, Mai-He; Yu, Fei-Hai
2012-01-01
Spatial heterogeneity in light supply is common in nature. Many studies have examined the effects of heterogeneous light supply on growth, morphology, physiology and biomass allocation of clonal plants, but few have tested those effects on intraspecific competition. In a greenhouse experiment, we grew one (no competition) or nine ramets (with intraspecific competition) of a stoloniferous clonal plant, Duchesnea indica, in three homogeneous light conditions (high, medium and low light intensity) and two heterogeneous ones differing in patch size (large and small patch treatments). The total light in the two heterogeneous treatments was the same as that in the homogeneous medium light treatment. Both decreasing light intensity and intraspecific competition significantly decreased the growth (biomass, number of ramets and total stolon length) of D. indica. As compared with the homogeneous medium light treatment, the large patch treatment significantly increased the growth of D. indica without intraspecific competition. However, the growth of D. indica with competition did not differ among the homogeneous medium light, the large and the small patch treatments. Consequently, light heterogeneity significantly increased intraspecific competition intensity, as measured by the decreased log response ratio. These results suggest that spatial heterogeneity in light supply can alter intraspecific interactions of clonal plants.
Stability Test for Transient-Temperature Calculations
NASA Technical Reports Server (NTRS)
Campbell, W.
1984-01-01
Graphical test helps assure numerical stability of calculations of transient temperature or diffusion in composite medium. Rectangular grid forms basis of two-dimensional finite-difference model for heat conduction or other diffusion like phenomena. Model enables calculation of transient heat transfer among up to four different materials that meet at grid point.
Chibani, Omar C-M Ma, Charlie
2014-05-15
Purpose: To present a new accelerated Monte Carlo code for CT-based dose calculations in high dose rate (HDR) brachytherapy. The new code (HDRMC) accounts for both tissue and nontissue heterogeneities (applicator and contrast medium). Methods: HDRMC uses a fast ray-tracing technique and detailed physics algorithms to transport photons through a 3D mesh of voxels representing the patient anatomy with applicator and contrast medium included. A precalculated phase space file for the{sup 192}Ir source is used as source term. HDRM is calibrated to calculated absolute dose for real plans. A postprocessing technique is used to include the exact density and composition of nontissue heterogeneities in the 3D phantom. Dwell positions and angular orientations of the source are reconstructed using data from the treatment planning system (TPS). Structure contours are also imported from the TPS to recalculate dose-volume histograms. Results: HDRMC was first benchmarked against the MCNP5 code for a single source in homogenous water and for a loaded gynecologic applicator in water. The accuracy of the voxel-based applicator model used in HDRMC was also verified by comparing 3D dose distributions and dose-volume parameters obtained using 1-mm{sup 3} versus 2-mm{sup 3} phantom resolutions. HDRMC can calculate the 3D dose distribution for a typical HDR cervix case with 2-mm resolution in 5 min on a single CPU. Examples of heterogeneity effects for two clinical cases (cervix and esophagus) were demonstrated using HDRMC. The neglect of tissue heterogeneity for the esophageal case leads to the overestimate of CTV D90, CTV D100, and spinal cord maximum dose by 3.2%, 3.9%, and 3.6%, respectively. Conclusions: A fast Monte Carlo code for CT-based dose calculations which does not require a prebuilt applicator model is developed for those HDR brachytherapy treatments that use CT-compatible applicators. Tissue and nontissue heterogeneities should be taken into account in modern HDR
Mixing, spreading and reaction in heterogeneous media: a brief review.
Dentz, Marco; Le Borgne, Tanguy; Englert, Andreas; Bijeljic, Branko
2011-03-01
Geological media exhibit heterogeneities in their hydraulic and chemical properties, which can lead to enhanced spreading and mixing of the transported species and induce an effective reaction behavior that is different from the one for a homogeneous medium. Chemical heterogeneities such as spatially varying adsorption properties and specific reactive surface areas can act directly on the chemical reaction dynamics and lead to different effective reaction laws. Physical heterogeneities affect mixing-limited chemical reactions in an indirect way by their impact on spreading and mixing of dissolved species. To understand and model large-scale reactive transport the interactions of these coupled processes need to be understood and quantified. This paper provides a brief review on approaches of non-reactive and reactive transport modeling in geological media.
Effect of geometry on concentration polarization in realistic heterogeneous permselective systems
NASA Astrophysics Data System (ADS)
Green, Yoav; Shloush, Shahar; Yossifon, Gilad
2014-04-01
This study extends previous analytical solutions of concentration polarization occurring solely in the depleted region, to the more realistic geometry consisting of a three-dimensional (3D) heterogeneous ion-permselective medium connecting two opposite microchambers (i.e., a three-layer system). Under the local electroneutrality approximation, the separation of variable methods is used to derive an analytical solution of the electrodiffusive problem for the two opposing asymmetric microchambers. The assumption of an ideal permselective medium allows for the analytic calculation of the 3D concentration and electric potential distributions as well as a current-voltage relation. It is shown that any asymmetry in the microchamber geometries will result in current rectification. Moreover, it is demonstrated that for non-negligible microchamber resistances, the conductance does not exhibit the expected saturation at low concentrations but instead shows a continuous decrease. The results are intended to facilitate a more direct comparison between theory and experiments, as now the voltage drop is across a realistic 3D and three-layer system.
SIMULATE-4 pin power calculations
Bahadir, T.; Lindahl, S. Oe
2006-07-01
A new pin power reconstruction module has been implemented in Studsvik Scandpower's next generation nodal code, SIMULATE-4. Heterogeneous pin powers are calculated by modulating multi-group pin powers from the sub-mesh solver of SIMULATE-4 with pin form factors from single-assembly CASMO-5 lattice calculations. The multi-group pin power model captures instantaneous spectral effects, and actinide tracking on the assembly sub-mesh describes exposure-induced pin power variations. Model details and verification tests against high order multi-assembly transport methods are presented. The accuracy of the new methods is also demonstrated by comparing SIMULATE-4 calculations with measured critical experiment pin powers. (authors)
Scattering characteristics in heterogeneously fractured reservoirs from waveform estimation
NASA Astrophysics Data System (ADS)
Shen, Feng; Toksöz, M. Nafi
2000-02-01
Offset-dependent characteristics of seismic scattering are useful for characterizing fractured reservoirs. We use two models that have different background medium properties and different azimuthal AVO responses to study elastic wave propagation and scattering in gas-saturated, heterogeneously fractured reservoirs. Heterogeneous fracture density distributions are built through stochastic modelling. Synthetic seismograms are generated by 3-D finite difference modelling, and waveforms along crack-normal and strike directions are considered in this paper. The multiple signal classification (MUSIC) frequency estimator is used in waveform estimation to provide frequency-domain attributes related to seismic wave scattering by fracture heterogeneity. Our results indicate that the strength of the scattering field is a function of the background medium. The strength also increases with increasing fracture scatterer density and with decreasing correlation length of spatial variations of fracture density. The scattering field is weak at the top of the fractured reservoir. The first-order results are dominated by velocity anisotropy of the mean fracture density field. However, the base of the fractured reservoir corresponds to a strong scattering field on which fracture heterogeneity has a larger effect and is characterized by the loss of coherence.
NASA Astrophysics Data System (ADS)
Ganesh, V.; Farzana, S.; Berchmans, Sheela
In this work, the direct electrochemical oxidation of carbohydrates using nickel hydroxide modified indium tin oxide (ITO) electrodes in alkaline medium is demonstrated; suggesting the feasibility of using carbohydrates as a novel fuel in alkaline fuel cells applications. The chosen monosaccharides are namely glucose and fructose; disaccharides such as sucrose and lactose; and sugar acid like ascorbic acid for this study. ITO electrodes are chemically modified using a hexagonal lyotropic liquid crystalline phase template electrodeposition of nickel. Structural morphology, growth, orientation and electrochemical behaviour of Ni deposits are characterized using SEM, XRD, XPS and cyclic voltammetry (CV), respectively. Further electrochemical potential cycling process in alkaline medium is employed to convert these Ni deposits into corresponding nickel hydroxide modified electrodes. These electrodes are used as novel platform to perform the electrocatalytic oxidation of various carbohydrates in alkaline medium. It was found that bare and Ni coated ITO electrodes are inactive towards carbohydrates oxidation. The heterogeneous rate constant values are determined and calculated to be two orders of magnitude higher in the case of template method when compared to non-template technique. The observed effect is attributed to the synergistic effect of higher surface area of these deposits and catalytic ability of Ni(II)/Ni(III) redox couple.
Massively Parallel Geostatistical Inversion of Coupled Processes in Heterogeneous Porous Media
NASA Astrophysics Data System (ADS)
Ngo, A.; Schwede, R. L.; Li, W.; Bastian, P.; Ippisch, O.; Cirpka, O. A.
2012-04-01
The quasi-linear geostatistical approach is an inversion scheme that can be used to estimate the spatial distribution of a heterogeneous hydraulic conductivity field. The estimated parameter field is considered to be a random variable that varies continuously in space, meets the measurements of dependent quantities (such as the hydraulic head, the concentration of a transported solute or its arrival time) and shows the required spatial correlation (described by certain variogram models). This is a method of conditioning a parameter field to observations. Upon discretization, this results in as many parameters as elements of the computational grid. For a full three dimensional representation of the heterogeneous subsurface it is hardly sufficient to work with resolutions (up to one million parameters) of the model domain that can be achieved on a serial computer. The forward problems to be solved within the inversion procedure consists of the elliptic steady-state groundwater flow equation and the formally elliptic but nearly hyperbolic steady-state advection-dominated solute transport equation in a heterogeneous porous medium. Both equations are discretized by Finite Element Methods (FEM) using fully scalable domain decomposition techniques. Whereas standard conforming FEM is sufficient for the flow equation, for the advection dominated transport equation, which rises well known numerical difficulties at sharp fronts or boundary layers, we use the streamline diffusion approach. The arising linear systems are solved using efficient iterative solvers with an AMG (algebraic multigrid) pre-conditioner. During each iteration step of the inversion scheme one needs to solve a multitude of forward and adjoint problems in order to calculate the sensitivities of each measurement and the related cross-covariance matrix of the unknown parameters and the observations. In order to reduce interprocess communications and to improve the scalability of the code on larger clusters
Political Jurisdictions in Heterogeneous Communities.
ERIC Educational Resources Information Center
Alesina, Alberto; Baqir, Reza; Hoxby, Caroline
2004-01-01
We investigate whether political jurisdictions form in response to the trade-off between economies of scale and the costs of a heterogeneous population. We consider heterogeneity in income, race, ethnicity, and religion, and we test the model using American school districts, school attendance areas, municipalities, and special districts. We find…
Query Expansion Using Heterogeneous Thesauri.
ERIC Educational Resources Information Center
Mandala, Rila; Tokunaga, Takenobu; Tanaka, Hozumi
2000-01-01
Proposes a method to improve the performance of information retrieval systems by expanding queries using heterogeneous thesauri. Experiments show that using heterogeneous thesauri with an appropriate weighting method results in better retrieval performance than using only one type of thesaurus. (Author/LRW)
Reference Point Heterogeneity.
Terzi, Ayse; Koedijk, Kees; Noussair, Charles N; Pownall, Rachel
2016-01-01
It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income. PMID:27672374
Terzi, Ayse; Koedijk, Kees; Noussair, Charles N.; Pownall, Rachel
2016-01-01
It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income. PMID:27672374
NASA Astrophysics Data System (ADS)
Sukhanov, Vitaly I.
1991-02-01
The paper summarizes the results of investigations performed to obtain deep 3-D holograms with 102 i0 mkm physical thickness allowing the postexposure amplification and the a posteriori changing of the grating parameters. This aim has been achieved by developing heterogeneous systems on the basis of porous glass with light-sensitive compositions introduced into it. 1. INTRODUCTION. LIGHT-SENSITIVE MEDIA FOR 3-D HOLOGRAMS RECORDING. The 3-D holograms have many useful properties: very high diffraction efficiency angular and spectral selectivity but low level of noise. It shoud be noted that in this case deep 3-D holograms are dealt with whose physical thickness is as high as 102 -i mkm. Such hologram recording is usually done using homogeneous light-sensitive media for example dyed acid-halide and electrooptical crystals photochrome glass photostructurized polimer compositions and so on. The nature of photophisical and photochemical processes responsible for the light sensitivity of these materials exclude the possibility of post-exposure treatment. This does not allow to enhance the recorded holograms and considerably hampers their fixing or makes it practically impossible. The object of our work is to create the media which are quite suitable for two-stage processes of the deep hologram formation with post-exposure processing. Such material must satisfy the following requirements: a)they must have high permeability for the developing substances in order to make the development duration suitable for practical applications b)they must be shrinkproof to prevent deformation of the
On Heterogeneous Covert Networks
NASA Astrophysics Data System (ADS)
Lindelauf, Roy; Borm, Peter; Hamers, Herbert
Covert organizations are constantly faced with a tradeoff between secrecy and operational efficiency. Lindelauf, Borm and Hamers [13] developed a theoretical framework to determine optimal homogeneous networks taking the above mentioned considerations explicitly into account. In this paper this framework is put to the test by applying it to the 2002 Jemaah Islamiyah Bali bombing. It is found that most aspects of this covert network can be explained by the theoretical framework. Some interactions however provide a higher risk to the network than others. The theoretical framework on covert networks is extended to accommodate for such heterogeneous interactions. Given a network structure the optimal location of one risky interaction is established. It is shown that the pair of individuals in the organization that should conduct the interaction that presents the highest risk to the organization, is the pair that is the least connected to the remainder of the network. Furthermore, optimal networks given a single risky interaction are approximated and compared. When choosing among a path, star and ring graph it is found that for low order graphs the path graph is best. When increasing the order of graphs under consideration a transition occurs such that the star graph becomes best. It is found that the higher the risk a single interaction presents to the covert network the later this transition from path to star graph occurs.
Terzi, Ayse; Koedijk, Kees; Noussair, Charles N.; Pownall, Rachel
2016-01-01
It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income.
Angiotensin II receptor heterogeneity
Herblin, W.F.; Chiu, A.T.; McCall, D.E.; Ardecky, R.J.; Carini, D.J.; Duncia, J.V.; Pease, L.J.; Wong, P.C.; Wexler, R.R.; Johnson, A.L. )
1991-04-01
The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of the authors earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes. Autoradiographic studies demonstrated that all of the labeling of the rat adrenal was blocked by unlabeled AII or saralasin, but not by DuP 753. The predominant receptor in the rat adrenal cortex (80%) is sensitive to dithiothreitol (DTT) and DuP 753, and is designated AII-1. The residual sites in the adrenal cortex and almost all of the sites in the rat adrenal medulla are insensitive to both DTT and DuP 753, but were blocked by EXP655. These sites have been confirmed by ligand binding studies and are designated AII-2. The rabbit adrenal cortex is unique in yielding a nonuniform distribution of AII-2 sites around the outer layer of glomerulosa cells. In the rabbit kidney, the sites on the glomeruli are AII-1, but the sites on the kidney capsule are AII-2. Angiotensin III appears to have a higher affinity for AII-2 sites since it inhibits the binding to the rabbit kidney capsule but not the glomeruli. Elucidation of the distribution and function of these diverse sites should permit the development of more selective and specific therapeutic strategies.
Acar, Hilal; Chiu-Tsao, Sou-Tung; Oezbay, Ismail; Kemikler, Goenuel; Tuncer, Samuray
2013-01-15
Purpose: (1) To measure absolute dose distributions in eye phantom for COMS eye plaques with {sup 125}I seeds (model I25.S16) using radiochromic EBT film dosimetry. (2) To determine the dose correction function for calculations involving the TG-43 formalism to account for the presence of the COMS eye plaque using Monte Carlo (MC) method specific to this seed model. (3) To test the heterogeneous dose calculation accuracy of the new version of Plaque Simulator (v5.3.9) against the EBT film data for this seed model. Methods: Using EBT film, absolute doses were measured for {sup 125}I seeds (model I25.S16) in COMS eye plaques (1) along the plaque's central axis for (a) uniformly loaded plaques (14-20 mm in diameter) and (b) a 20 mm plaque with single seed, and (2) in off-axis direction at depths of 5 and 12 mm for all four plaque sizes. The EBT film calibration was performed at {sup 125}I photon energy. MC calculations using MCNP5 code for a single seed at the center of a 20 mm plaque in homogeneous water and polystyrene medium were performed. The heterogeneity dose correction function was determined from the MC calculations. These function values at various depths were entered into PS software (v5.3.9) to calculate the heterogeneous dose distributions for the uniformly loaded plaques (of all four sizes). The dose distributions with homogeneous water assumptions were also calculated using PS for comparison. The EBT film measured absolute dose rate values (film) were compared with those calculated using PS with homogeneous assumption (PS Homo) and heterogeneity correction (PS Hetero). The values of dose ratio (film/PS Homo) and (film/PS Hetero) were obtained. Results: The central axis depth dose rate values for a single seed in 20 mm plaque measured using EBT film and calculated with MCNP5 code (both in ploystyrene phantom) were compared, and agreement within 9% was found. The dose ratio (film/PS Homo) values were substantially lower than unity (mostly between 0.8 and 0
Geometrical ambiguity of pair statistics. II. Heterogeneous media
NASA Astrophysics Data System (ADS)
Jiao, Yang; Stillinger, Frank H.; Torquato, Salvatore
2010-07-01
In the first part of this series of two papers [Y. Jiao, F. H. Stillinger, and S. Torquato, Phys. Rev. E 81, 011105 (2010)10.1103/PhysRevE.81.011105], we considered the geometrical ambiguity of pair statistics associated with point configurations. Here we focus on the analogous problem for heterogeneous media (materials). Heterogeneous media are ubiquitous in a host of contexts, including composites and granular media, biological tissues, ecological patterns, and astrophysical structures. The complex structures of heterogeneous media are usually characterized via statistical descriptors, such as the n -point correlation function Sn . An intricate inverse problem of practical importance is to what extent a medium can be reconstructed from the two-point correlation function S2 of a target medium. Recently, general claims of the uniqueness of reconstructions using S2 have been made based on numerical studies, which implies that S2 suffices to uniquely determine the structure of a medium within certain numerical accuracy. In this paper, we provide a systematic approach to characterize the geometrical ambiguity of S2 for both continuous two-phase heterogeneous media and their digitized representations in a mathematically precise way. In particular, we derive the exact conditions for the case where two distinct media possess identical S2 , i.e., they form a degenerate pair. The degeneracy conditions are given in terms of integral and algebraic equations for continuous media and their digitized representations, respectively. By examining these equations and constructing their rigorous solutions for specific examples, we conclusively show that in general S2 is indeed not sufficient information to uniquely determine the structure of the medium, which is consistent with the results of our recent study on heterogeneous-media reconstruction [Y. Jiao, F. H. Stillinger, and S. Torquato, Proc. Natl. Acad. Sci. U.S.A. 106, 17634 (2009)10.1073/pnas.0905919106]. The analytical
Medium modification of hadronic distributions in SIDIS
NASA Astrophysics Data System (ADS)
Avagyan, Harut
2014-09-01
Medium modifications of spin-orbit correlations in Semi-Inclusive Deep Inelastic Scattering (SIDIS) processes with polarized leptons and targets provide access to studies of partonic distributions in nucleons and nuclei. Measurements of multiplicities and different spin and azimuthal asymmetries can be used to extract the quark transverse momentum broadening Δ2 F and/or quark transport parameter \\qcirc studied theoretically in the corresponding cases. We will present ongoing studies of medium modifications of SIDIS observables at Jefferson Lab, and proposed future measurement to study the transverse momentum broadening and some spin and azimuthal asymmetries in reactions using polarized lepton and polarized and unpolarized nuclei. Calculations have been preformed assuming factorized Gaussian dependence on intrinsic momenta for the TMD distributions and a Gaussian dilution from the fragmentation functions.
Node assignment in heterogeneous computing
NASA Technical Reports Server (NTRS)
Som, Sukhamoy
1993-01-01
A number of node assignment schemes, both static and dynamic, are explored for the Algorithm to Architecture Mapping Model (ATAMM). The architecture under consideration consists of heterogeneous processors and implements dataflow models of real-time applications. Terminology is developed for heterogeneous computing. New definitions are added to the ATAMM for token and assignment classifications. It is proved that a periodic execution is possible for dataflow graphs. Assignment algorithms are developed and proved. A design procedure is described for satisfying an objective function in an heterogeneous architecture. Several examples are provided for illustration.
Heterogeneous Oxidation of Catechol.
Pillar, Elizabeth A; Zhou, Ruixin; Guzman, Marcelo I
2015-10-15
Natural and anthropogenic emissions of aromatic hydrocarbons from biomass burning, agro-industrial settings, and fossil fuel combustion contribute precursors to secondary aerosol formation (SOA). How these compounds are processed under humid tropospheric conditions is the focus of current attention to understand their environmental fate. This work shows how catechol thin films, a model for oxygenated aromatic hydrocarbons present in biomass burning and combustion aerosols, undergo heterogeneous oxidation at the air-solid interface under variable relative humidity (RH = 0-90%). The maximum reactive uptake coefficient of O3(g) by catechol γO3 = (7.49 ± 0.35) × 10(-6) occurs for 90% RH. Upon exposure of ca. 104-μm thick catechol films to O3(g) mixing ratios between 230 ppbv and 25 ppmv, three main reaction pathways are observed. (1) The cleavage of the 1,2 carbon-carbon bond at the air-solid interface resulting in the formation of cis,cis-muconic acid via primary ozonide and hydroperoxide intermediates. Further direct ozonolysis of cis,cis-muconic yields glyoxylic, oxalic, crotonic, and maleic acids. (2) A second pathway is evidenced by the presence of Baeyer-Villiger oxidation products including glutaconic 4-hydroxy-2-butenoic and 5-oxo-2-pentenoic acids during electrospray ionization mass spectrometry (MS) and ion chromatography MS analyses. (3) Finally, indirect oxidation by in situ produced hydroxyl radical (HO(•)) results in the generation of semiquinone radical intermediates toward the synthesis of polyhydoxylated aromatic rings such as tri-, tetra-, and penta-hydroxybenzene. Remarkably, heavier polyhydroxylated biphenyl and terphenyl products present in the extracted oxidized films result from coupling reactions of semiquinones of catechol and its polyhydroxylated rings. The direct ozonolysis of 1,2,3- and 1,2,4-trihydroxybenezene yields 2- and 3-hydroxy-cis,cis-muconic acid, respectively. The production of 2,4- or 3,4-dihdroxyhex-2-enedioic acid is
New medium licensed for campylobacter
Technology Transfer Automated Retrieval System (TEKTRAN)
A medium, “Campy-Cefex”, has been licensed by the ARS Office of Technology Transfer with Becton Dickinson (No. 1412-002) and Neogen (No. 1412-001) based on patent No. 5,891,709, “Campy-Cefex Selective and Differential Medium for Campylobacter” by Dr. Norman Stern of the Poultry Microbiological Safet...
Homogeneous, Heterogeneous, and Enzymatic Catalysis.
ERIC Educational Resources Information Center
Oyama, S. Ted; Somorjai, Gabor A.
1988-01-01
Discusses three areas of catalysis: homegeneous, heterogeneous, and enzymatic. Explains fundamentals and economic impact of catalysis. Lists and discusses common industrial catalysts. Provides a list of 107 references. (MVL)
Heterogeneity in motor driven transport
NASA Astrophysics Data System (ADS)
Tabei, Ali
2015-03-01
I will discuss quantitative analysis of particle tracking data for motor driven vesicles inside an insulin secreting cell. We use this method to study the dynamical and structural heterogeneity inside the cell. I will discuss our effort to explain the origin of observed heterogeneity in intracellular transport. Finally, I will explain how analyzing directional correlations in transport trajectories reveals self-similarity in the diffusion media.
NASA Astrophysics Data System (ADS)
Song, Yongjia; Hu, Hengshan; Rudnicki, John W.; Duan, Yunda
2016-06-01
An exact analytical solution is presented for the effective dynamic transverse shear modulus in a heterogeneous fluid-filled porous solid containing cylindrical inclusions. The complex and frequency-dependent properties of the dynamic shear modulus are caused by the physical mechanism of mesoscopic-scale wave-induced fluid flow whose scale is smaller than wavelength but larger than the size of pores. Our model consists of three phases: a long cylindrical inclusion, a cylindrical shell of poroelastic matrix material with different mechanical and/or hydraulic properties than the inclusion and an outer region of effective homogeneous medium of laterally infinite extent. The behavior of both the inclusion and the matrix is described by Biot's consolidation equations, whereas the surrounding effective medium which is used to describe the effective transverse shear properties of the inner poroelastic composite is assumed to be a viscoelastic solid whose complex transverse shear modulus needs to be determined. The determined effective transverse shear modulus is used to quantify the S-wave attenuation and velocity dispersion in heterogeneous fluid-filled poroelastic rocks. The calculation shows the relaxation frequency and relative position of various fluid saturation dispersion curves predicted by this study exhibit very good agreement with those of a previous two-dimensional finite-element simulation. For the double-porosity model (inclusions having a different solid frame than the matrix but the same pore fluid as the matrix) the effective shear modulus also exhibits a size-dependent characteristic that the relaxation frequency moves to lower frequencies by two orders of magnitude if the radius of the cylindrical poroelastic composite increases by one order of magnitude. For the patchy-saturation model (inclusions having the same solid frame as the matrix but with a different pore fluid from the matrix), the heterogeneity in pore fluid cannot cause any attenuation in
NASA Astrophysics Data System (ADS)
Song, Yongjia; Hu, Hengshan; Rudnicki, John W.; Duan, Yunda
2016-09-01
An exact analytical solution is presented for the effective dynamic transverse shear modulus in a heterogeneous fluid-filled porous solid containing cylindrical inclusions. The complex and frequency-dependent properties of the dynamic shear modulus are caused by the physical mechanism of mesoscopic-scale wave-induced fluid flow whose scale is smaller than wavelength but larger than the size of pores. Our model consists of three phases: a long cylindrical inclusion, a cylindrical shell of poroelastic matrix material with different mechanical and/or hydraulic properties than the inclusion and an outer region of effective homogeneous medium of laterally infinite extent. The behavior of both the inclusion and the matrix is described by Biot's consolidation equations, whereas the surrounding effective medium which is used to describe the effective transverse shear properties of the inner poroelastic composite is assumed to be a viscoelastic solid whose complex transverse shear modulus needs to be determined. The determined effective transverse shear modulus is used to quantify the S-wave attenuation and velocity dispersion in heterogeneous fluid-filled poroelastic rocks. The calculation shows the relaxation frequency and relative position of various fluid saturation dispersion curves predicted by this study exhibit very good agreement with those of a previous 2-D finite-element simulation. For the double-porosity model (inclusions having a different solid frame than the matrix but the same pore fluid as the matrix) the effective shear modulus also exhibits a size-dependent characteristic that the relaxation frequency moves to lower frequencies by two orders of magnitude if the radius of the cylindrical poroelastic composite increases by one order of magnitude. For the patchy-saturation model (inclusions having the same solid frame as the matrix but with a different pore fluid from the matrix), the heterogeneity in pore fluid cannot cause any attenuation in the
Tezuka, K; Hayashi, M; Ishihara, H; Onozaki, K; Nishimura, M; Takahashi, N
1993-03-01
The N-linked oligosaccharide moieties of sycamore (Acer pseudoplatanus L.) laccase are known to be highly heterogeneous. We confirmed that this oligosaccharide heterogeneity was caused not only during the oligosaccharide biosynthesis in Golgi apparatus, but also after the excretion of laccase protein into a culture medium. The culture medium for the sycamore cells (Acer pseudoplatanus L.) contained beta-galactosidase, alpha-L-fucosidase, beta-N-acetylglucosaminidase, alpha-mannosidase and beta-xylosidase activities. We showed that the largest sugar chain in laccase, oligosaccharide F, [formula: see text] was degraded to [formula: see text] by a crude exoglycosidase mixture in the culture medium.
PUNCH: Population Characterization of Heterogeneity.
Tunc, Birkan; Ghanbari, Yasser; Smith, Alex R; Pandey, Juhi; Browne, Aaron; Schultz, Robert T; Verma, Ragini
2014-09-01
Neuropsychiatric disorders are notoriously heterogeneous in their presentation, which precludes straightforward and objective description of the differences between affected and typical populations that therefore makes finding reliable biomarkers a challenge. This difficulty underlines the need for reliable methods to capture sample characteristics of heterogeneity using a single continuous measure, incorporating the multitude of scores used to describe different aspects of functioning. This study addresses this challenge by proposing a general method of identifying and quantifying the heterogeneity of any clinical population using a severity measure called the PUNCH (Population Characterization of Heterogeneity). PUNCH is a decision level fusion technique to incorporate decisions of various phenotypic scores, while providing interpretable weights for scores. We provide applications of our framework to simulated datasets and to a large sample of youth with Autism Spectrum Disorder (ASD). Next we stratify PUNCH scores in our ASD sample and show how severity moderates findings of group differences in diffusion weighted brain imaging data; more severely affected subgroups of ASD show expanded differences compared to age and gender matched healthy controls. Results demonstrate the ability of our measure in quantifying the underlying heterogeneity of the clinical samples, and suggest its utility in providing researchers with reliable severity assessments incorporating population heterogeneity.
Analysis of active renin heterogeneity.
Katz, S A; Malvin, R L; Lee, J; Kim, S H; Murray, R D; Opsahl, J A; Abraham, P A
1991-09-01
Active renin is a heterogeneous enzyme that can be separated into multiple forms with high-resolution isoelectric focusing. The isoelectric heterogeneity may result from differences in glycosylation between the different forms. In order to determine the relationship between active renin heterogeneity and differences in composition or attachment of oligosaccharides, two separate experiments were performed: (i) Tunicamycin, which interferes with normal glycosylation processing, increased the proportion of relatively basic renin forms secreted into the incubation media by rat renal cortical slices. (ii) Endoglycosidase F, which enzymatically removes carbohydrate from some classes of glycoprotein, similarly increased the proportion of relatively basic forms when incubated with active human recombinant renin. In addition, further studies with inhibitors of human renin activity revealed that the heterogeneous renin forms were similarly inhibited by two separate renin inhibitors. These results are consistent with the hypothesis that renin isoelectric heterogeneity is due in part to differences in carbohydrate moiety attachment and that the heterogeneity of renin does not influence access of direct renin inhibitors to the active site of renin.
Analysis of active renin heterogeneity.
Katz, S A; Malvin, R L; Lee, J; Kim, S H; Murray, R D; Opsahl, J A; Abraham, P A
1991-09-01
Active renin is a heterogeneous enzyme that can be separated into multiple forms with high-resolution isoelectric focusing. The isoelectric heterogeneity may result from differences in glycosylation between the different forms. In order to determine the relationship between active renin heterogeneity and differences in composition or attachment of oligosaccharides, two separate experiments were performed: (i) Tunicamycin, which interferes with normal glycosylation processing, increased the proportion of relatively basic renin forms secreted into the incubation media by rat renal cortical slices. (ii) Endoglycosidase F, which enzymatically removes carbohydrate from some classes of glycoprotein, similarly increased the proportion of relatively basic forms when incubated with active human recombinant renin. In addition, further studies with inhibitors of human renin activity revealed that the heterogeneous renin forms were similarly inhibited by two separate renin inhibitors. These results are consistent with the hypothesis that renin isoelectric heterogeneity is due in part to differences in carbohydrate moiety attachment and that the heterogeneity of renin does not influence access of direct renin inhibitors to the active site of renin. PMID:1908097
Discriminating cellular heterogeneity using microwell-based RNA cytometry
Dimov, Ivan K.; Lu, Rong; Lee, Eric P.; Seita, Jun; Sahoo, Debashis; Park, Seung-min; Weissman, Irving L.; Lee, Luke P.
2014-01-01
Discriminating cellular heterogeneity is important for understanding cellular physiology. However, it is limited by the technical difficulties of single-cell measurements. Here, we develop a two-stage system to determine cellular heterogeneity. In the first stage, we perform multiplex single-cell RNA-cytometry in a microwell array containing over 60,000 reaction chambers. In the second stage, we use the RNA-cytometry data to determine cellular heterogeneity by providing a heterogeneity likelihood score. Moreover, we use Monte-Carlo simulation and RNA-cytometry data to calculate the minimum number of cells required for detecting heterogeneity. We applied this system to characterize the RNA distributions of aging related genes in a highly purified mouse hematopoietic stem cell population. We identified genes that reveal novel heterogeneity of these cells. We also show that changes in expression of genes such as Birc6 during aging can be attributed to the shift of relative portions of cells in the high-expressing subgroup versus low-expressing subgroup. PMID:24667995
High performance simulation of environmental tracers in heterogeneous domains.
Gardner, William P; Hammond, Glenn; Lichtner, Peter
2015-04-01
In this study, we use PFLOTRAN, a highly scalable, parallel, flow, and reactive transport code to simulate the concentrations of 3H, 3He, CFC-11, CFC-12, CFC-113, SF6, 39Ar, and the mean groundwater age in heterogeneous fields on grids with an excess of 10 million nodes. We utilize this computational platform to simulate the concentration of multiple tracers in high-resolution, heterogeneous 2D and 3D domains, and calculate tracer-derived ages. Tracer-derived ages show systematic biases toward younger ages when the groundwater age distribution contains water older than the maximum tracer age. The deviation of the tracer-derived age distribution from the true groundwater age distribution increases with increasing heterogeneity of the system. However, the effect of heterogeneity is diminished as the mean travel time gets closer to the tracer age limit. Age distributions in 3D domains differ significantly from 2D domains. 3D simulations show decreased mean age, and less variance in age distribution for identical heterogeneity statistics. High-performance computing allows for investigation of tracer and groundwater age systematics in high-resolution domains, providing a platform for understanding and utilizing environmental tracer and groundwater age information in heterogeneous 3D systems. PMID:24372403
High performance simulation of environmental tracers in heterogeneous domains.
Gardner, William P; Hammond, Glenn; Lichtner, Peter
2015-04-01
In this study, we use PFLOTRAN, a highly scalable, parallel, flow, and reactive transport code to simulate the concentrations of 3H, 3He, CFC-11, CFC-12, CFC-113, SF6, 39Ar, and the mean groundwater age in heterogeneous fields on grids with an excess of 10 million nodes. We utilize this computational platform to simulate the concentration of multiple tracers in high-resolution, heterogeneous 2D and 3D domains, and calculate tracer-derived ages. Tracer-derived ages show systematic biases toward younger ages when the groundwater age distribution contains water older than the maximum tracer age. The deviation of the tracer-derived age distribution from the true groundwater age distribution increases with increasing heterogeneity of the system. However, the effect of heterogeneity is diminished as the mean travel time gets closer to the tracer age limit. Age distributions in 3D domains differ significantly from 2D domains. 3D simulations show decreased mean age, and less variance in age distribution for identical heterogeneity statistics. High-performance computing allows for investigation of tracer and groundwater age systematics in high-resolution domains, providing a platform for understanding and utilizing environmental tracer and groundwater age information in heterogeneous 3D systems.
NASA Astrophysics Data System (ADS)
Mishchenko, Michael I.; Dlugach, Janna M.; Yurkin, Maxim A.; Bi, Lei; Cairns, Brian; Liu, Li; Panetta, R. Lee; Travis, Larry D.; Yang, Ping; Zakharova, Nadezhda T.
2016-05-01
A discrete random medium is an object in the form of a finite volume of a vacuum or a homogeneous material medium filled with quasi-randomly and quasi-uniformly distributed discrete macroscopic impurities called small particles. Such objects are ubiquitous in natural and artificial environments. They are often characterized by analyzing theoretically the results of laboratory, in situ, or remote-sensing measurements of the scattering of light and other electromagnetic radiation. Electromagnetic scattering and absorption by particles can also affect the energy budget of a discrete random medium and hence various ambient physical and chemical processes. In either case electromagnetic scattering must be modeled in terms of appropriate optical observables, i.e., quadratic or bilinear forms in the field that quantify the reading of a relevant optical instrument or the electromagnetic energy budget. It is generally believed that time-harmonic Maxwell's equations can accurately describe elastic electromagnetic scattering by macroscopic particulate media that change in time much more slowly than the incident electromagnetic field. However, direct solutions of these equations for discrete random media had been impracticable until quite recently. This has led to a widespread use of various phenomenological approaches in situations when their very applicability can be questioned. Recently, however, a new branch of physical optics has emerged wherein electromagnetic scattering by discrete and discretely heterogeneous random media is modeled directly by using analytical or numerically exact computer solutions of the Maxwell equations. Therefore, the main objective of this Report is to formulate the general theoretical framework of electromagnetic scattering by discrete random media rooted in the Maxwell-Lorentz electromagnetics and discuss its immediate analytical and numerical consequences. Starting from the microscopic Maxwell-Lorentz equations, we trace the development of
Diffusion of hidden charm mesons in hadronic medium
NASA Astrophysics Data System (ADS)
Mitra, Sukanya; Ghosh, Sabyasachi; Das, Santosh K.; Sarkar, Sourav; Alam, Jan-e.
2016-07-01
The drag and diffusion coefficients of a hot hadronic medium have been evaluated by using hidden charm mesons as probes. The scattering amplitudes required for the evaluation of these coefficients are calculated using an effective theory and scattering lengths obtained from lattice QCD calculations. It is found that although the magnitude of the transport coefficients are small their temperature variation is strong. The insignificant momentum diffusion of J / ψ in the hadronic medium keeps their momentum distribution largely unaltered. Therefore, the task of characterization of quark gluon plasma by using the observed suppression of J / ψ at high momentum will be comparatively easier.
Huang, Yuheng; Tran, Ivan; Agrawal, Aneil F
2016-07-01
Environmental heterogeneity helps maintain genetic variation in fitness. Therefore, one might predict that populations living in heterogeneous environments have higher adaptive potential than populations living in homogeneous environments. Such a prediction could be useful in guiding conservation priorities without requiring detailed genetic studies. However, this prediction will be true only if the additional genetic variation maintained by environmental heterogeneity can be used to respond to novel selection. Here we examine the effect of environmental heterogeneity on future adaptability using replicated experimental Drosophila melanogaster populations that had previously evolved for ∼100 generations under one of four selective regimes: constant salt-enriched larvae medium, constant cadmium-enriched larvae medium, and two heterogeneous regimes that vary either temporally or spatially between the two media. Replicates of these experimental populations were subjected to a novel heat stress while being maintained in their original larval diet selection regimes. Adaptation to increased temperature was measured with respect to female productivity and male siring success after ∼20 generations. For female productivity, there was evidence of adaptation overall and heterogeneous populations had a larger adaptive response than homogeneous populations. There was less evidence of adaptation overall for male siring success and no support for faster adaptation in heterogeneous populations. PMID:27322119
Ono, Kaoru; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu; Hirokawa, Yutaka
2010-08-15
Purpose: In this study, the authors evaluated the accuracy of dose calculations performed by the convolution/superposition based anisotropic analytical algorithm (AAA) in lung equivalent heterogeneities with and without bone equivalent heterogeneities. Methods: Calculations of PDDs using the AAA and Monte Carlo simulations (MCNP4C) were compared to ionization chamber measurements with a heterogeneous phantom consisting of lung equivalent and bone equivalent materials. Both 6 and 10 MV photon beams of 4x4 and 10x10 cm{sup 2} field sizes were used for the simulations. Furthermore, changes of energy spectrum with depth for the heterogeneous phantom using MCNP were calculated. Results: The ionization chamber measurements and MCNP calculations in a lung equivalent phantom were in good agreement, having an average deviation of only 0.64{+-}0.45%. For both 6 and 10 MV beams, the average deviation was less than 2% for the 4x4 and 10x10 cm{sup 2} fields in the water-lung equivalent phantom and the 4x4 cm{sup 2} field in the water-lung-bone equivalent phantom. Maximum deviations for the 10x10 cm{sup 2} field in the lung equivalent phantom before and after the bone slab were 5.0% and 4.1%, respectively. The Monte Carlo simulation demonstrated an increase of the low-energy photon component in these regions, more for the 10x10 cm{sup 2} field compared to the 4x4 cm{sup 2} field. Conclusions: The low-energy photon by Monte Carlo simulation component increases sharply in larger fields when there is a significant presence of bone equivalent heterogeneities. This leads to great changes in the build-up and build-down at the interfaces of different density materials. The AAA calculation modeling of the effect is not deemed to be sufficiently accurate.
Intra-tumor Genetic Heterogeneity in Rectal Cancer
Hardiman, Karin M.; Ulintz, Peter J.; Kuick, Rork; Hovelson, Daniel H.; Gates, Christopher M.; Bhasi, Ashwini; Grant, Ana Rodrigues; Liu, Jianhua; Cani, Andi K.; Greenson, Joel; Tomlins, Scott; Fearon, Eric R.
2015-01-01
Colorectal cancer arises in part from the cumulative effects of multiple gene lesions. Recent studies in selected cancer types have revealed significant intra-tumor genetic heterogeneity and highlighted its potential role in disease progression and resistance to therapy. We hypothesized the existence of significant intra-tumor genetic heterogeneity in rectal cancers involving variations in localized somatic mutations and copy number abnormalities. Two or three spatially disparate regions from each of six rectal tumors were dissected and subjected to next-generation whole exome DNA sequencing, Oncoscan SNP arrays, and targeted confirmatory sequencing and analysis. The resulting data were integrated to define subclones using SciClone. Mutant-allele tumor heterogeneity (MATH) scores, mutant allele frequency correlation, and mutation percent concordance were calculated, and copy number analysis including measurement of correlation between samples was performed. Somatic mutations profiles in individual cancers were similar to prior studies, with some variants found in previously reported significantly mutated genes and many patient-specific mutations in each tumor. Significant intra-tumor heterogeneity was identified in the spatially disparate regions of individual cancers. All tumors had some heterogeneity but the degree of heterogeneity was quite variable in the samples studied. We found that 67–97% of exonic somatic mutations were shared among all regions of an individual’s tumor. The SciClone computational method identified 2 to 8 shared and unshared subclones in the spatially disparate areas in each tumor. MATH scores ranged from 7 to 41. Allele frequency correlation scores ranged from R2 = 0.69 to 0.96. Measurements of correlation between samples for copy number changes varied from R2 = 0.74 to 0.93. All tumors had some heterogeneity, but the degree was highly variable in the samples studied. The occurrence of significant intra-tumor heterogeneity may allow
A simple analytical method for heterogeneity corrections in low dose rate prostate brachytherapy
NASA Astrophysics Data System (ADS)
Hueso-González, Fernando; Vijande, Javier; Ballester, Facundo; Perez-Calatayud, Jose; Siebert, Frank-André
2015-07-01
In low energy brachytherapy, the presence of tissue heterogeneities contributes significantly to the discrepancies observed between treatment plan and delivered dose. In this work, we present a simplified analytical dose calculation algorithm for heterogeneous tissue. We compare it with Monte Carlo computations and assess its suitability for integration in clinical treatment planning systems. The algorithm, named as RayStretch, is based on the classic equivalent path length method and TG-43 reference data. Analytical and Monte Carlo dose calculations using Penelope2008 are compared for a benchmark case: a prostate patient with calcifications. The results show a remarkable agreement between simulation and algorithm, the latter having, in addition, a high calculation speed. The proposed analytical model is compatible with clinical real-time treatment planning systems based on TG-43 consensus datasets for improving dose calculation and treatment quality in heterogeneous tissue. Moreover, the algorithm is applicable for any type of heterogeneities.
Random lasing in a nanocomposite medium
Smetanin, Sergei N; Basiev, Tasoltan T
2013-01-31
The characteristics of a random laser based on a nanocomposite medium consisting of a transparent dielectric and scattering doped nanocrystals are calculated. It is proposed to use ytterbium laser media with a high concentration of active ions as nanocrystals and to use gases, liquids, or solid dielectrics with a refractive index lower than that of nanocrystals as dielectric matrices for nanocrystals. Based on the concept of nonresonant distributed feedback due to the Rayleigh scattering, an expression is obtained for the minimum length of a nanocomposite laser medium at which the random lasing threshold is overcome. Expressions are found for the critical (maximum) and the optimal size of nanocrystals, as well as for the optimal relative refractive index of nanocomposites that corresponds not only to the maximum gain but also to the minimum of the medium threshold length at the optimal size of nanocrystals. It is shown that the optimal relative refractive index of a nanocomposite increases with increasing pump level, but is independent of the other nanocomposite parameters. (nanocomposites)
Medium energy charged particle data for evaluation
Pearlstein, S.
1989-01-01
Medium energy charged particles incident on targets can cause a variety of nuclear reactions. Charged particle transport calculations require access to a large body of cross-section data which results in interest in an evaluated charge particle data library. Developing an evaluated data library can involve several steps. An index to the literature on measurements and theory is useful to locate information relevant to data evaluation. A computerized compilation of measurements facilitates the intercomparison of different experiments and the determination of how well data are known. Nuclear models, based on theory or phenonological evidence, are compared with experiment and where validated, are used to fill in regions where experimental data are not available. Finally, the selected data is placed into computer readable formats for use in transport calculations. 16 refs.
Aggregation effects of surface heterogeneity in land surface processes
NASA Astrophysics Data System (ADS)
Su, Z.; Pelgrum, H.; Menenti, M.
In order to investigate the aggregation effects of surface heterogeneity in land surface processes we have adapted a theory of aggregation. Two strategies have been adopted: 1) Aggregation of radiative fluxes. The aggregated radiative fluxes are used to derive input parameters that are then used to calculate the aerodynamic fluxes at different aggregation levels. This is equivalent to observing the same area at different resolutions using a certain remote sensor, and then calculating the aerodynamic fluxes correspondingly. 2) Aggregation of aerodynamic fluxes calculated at the original observation scale to different aggregation levels. A case study has been conducted to identify the effects of aggregation on areal estimates of sensible and latent heat fluxes. The length scales of surface variables in heterogeneous landscapes are estimated by means of wavelet analysis.
Dealing with spatial heterogeneity
NASA Astrophysics Data System (ADS)
Marsily, Gh.; Delay, F.; Gonçalvès, J.; Renard, Ph.; Teles, V.; Violette, S.
2005-03-01
Heterogeneity can be dealt with by defining homogeneous equivalent properties, known as averaging, or by trying to describe the spatial variability of the rock properties from geologic observations and local measurements. The techniques available for these descriptions are mostly continuous Geostatistical models, or discontinuous facies models such as the Boolean, Indicator or Gaussian-Threshold models and the Markov chain model. These facies models are better suited to treating issues of rock strata connectivity, e.g. buried high permeability channels or low permeability barriers, which greatly affect flow and, above all, transport in aquifers. Genetic models provide new ways to incorporate more geology into the facies description, an approach that has been well developed in the oil industry, but not enough in hydrogeology. The conclusion is that future work should be focused on improving the facies models, comparing them, and designing new in situ testing procedures (including geophysics) that would help identify the facies geometry and properties. A world-wide catalog of aquifer facies geometry and properties, which could combine site genesis and description with methods used to assess the system, would be of great value for practical applications. On peut aborder le problème de l'hétérogénéité en s'efforçant de définir une perméabilité équivalente homogène, par prise de moyenne, ou au contraire en décrivant la variation dans l'espace des propriétés des roches à partir des observations géologiques et des mesures locales. Les techniques disponibles pour une telle description sont soit continues, comme l'approche Géostatistique, soit discontinues, comme les modèles de faciès, Booléens, ou bien par Indicatrices ou Gaussiennes Seuillées, ou enfin Markoviens. Ces modèles de faciès sont mieux capables de prendre en compte la connectivité des strates géologiques, telles que les chenaux enfouis à forte perméabilité, ou au contraire les faci
Dealing with spatial heterogeneity
NASA Astrophysics Data System (ADS)
Marsily, Gh.; Delay, F.; Gonçalvès, J.; Renard, Ph.; Teles, V.; Violette, S.
2005-03-01
Heterogeneity can be dealt with by defining homogeneous equivalent properties, known as averaging, or by trying to describe the spatial variability of the rock properties from geologic observations and local measurements. The techniques available for these descriptions are mostly continuous Geostatistical models, or discontinuous facies models such as the Boolean, Indicator or Gaussian-Threshold models and the Markov chain model. These facies models are better suited to treating issues of rock strata connectivity, e.g. buried high permeability channels or low permeability barriers, which greatly affect flow and, above all, transport in aquifers. Genetic models provide new ways to incorporate more geology into the facies description, an approach that has been well developed in the oil industry, but not enough in hydrogeology. The conclusion is that future work should be focused on improving the facies models, comparing them, and designing new in situ testing procedures (including geophysics) that would help identify the facies geometry and properties. A world-wide catalog of aquifer facies geometry and properties, which could combine site genesis and description with methods used to assess the system, would be of great value for practical applications. On peut aborder le problème de l'hétérogénéité en s'efforçant de définir une perméabilité équivalente homogène, par prise de moyenne, ou au contraire en décrivant la variation dans l'espace des propriétés des roches à partir des observations géologiques et des mesures locales. Les techniques disponibles pour une telle description sont soit continues, comme l'approche Géostatistique, soit discontinues, comme les modèles de faciès, Booléens, ou bien par Indicatrices ou Gaussiennes Seuillées, ou enfin Markoviens. Ces modèles de faciès sont mieux capables de prendre en compte la connectivité des strates géologiques, telles que les chenaux enfouis à forte perméabilité, ou au contraire les faci
Monheit, G D
2001-07-01
The combination medium-depth chemical peel (Jessner's solution +35% TCA) has been accepted as a safe, reliable, and effective method for the treatment of moderate photoaging skin. This article discusses the procedure in detail, including postoperative considerations. PMID:11599398
An improved holographic recording medium
NASA Technical Reports Server (NTRS)
Gange, R. A.
1973-01-01
Solid, linear chain hydrocarbons with molecular weight ranging from about 300 to 2000 can serve as long-lived recording medium in optical memory system. Suitable recording hydrocarbons include microcrystalline waxes and low molecular weight polymers or ethylene.
On-Site was developed to provide modelers and model reviewers with prepackaged tools ("calculators") for performing site assessment calculations. The philosophy behind OnSite is that the convenience of the prepackaged calculators helps provide consistency for simple calculations,...
Treeby, Bradley E; Jaros, Jiri; Rendell, Alistair P; Cox, B T
2012-06-01
The simulation of nonlinear ultrasound propagation through tissue realistic media has a wide range of practical applications. However, this is a computationally difficult problem due to the large size of the computational domain compared to the acoustic wavelength. Here, the k-space pseudospectral method is used to reduce the number of grid points required per wavelength for accurate simulations. The model is based on coupled first-order acoustic equations valid for nonlinear wave propagation in heterogeneous media with power law absorption. These are derived from the equations of fluid mechanics and include a pressure-density relation that incorporates the effects of nonlinearity, power law absorption, and medium heterogeneities. The additional terms accounting for convective nonlinearity and power law absorption are expressed as spatial gradients making them efficient to numerically encode. The governing equations are then discretized using a k-space pseudospectral technique in which the spatial gradients are computed using the Fourier-collocation method. This increases the accuracy of the gradient calculation and thus relaxes the requirement for dense computational grids compared to conventional finite difference methods. The accuracy and utility of the developed model is demonstrated via several numerical experiments, including the 3D simulation of the beam pattern from a clinical ultrasound probe. PMID:22712907
Pollitz, F.F.
2002-01-01
I present a new algorithm for calculating seismic wave propagation through a three-dimensional heterogeneous medium using the framework of mode coupling theory originally developed to perform very low frequency (f < ???0.01-0.05 Hz) seismic wavefield computation. It is a Greens function approach for multiple scattering within a defined volume and employs a truncated traveling wave basis set using the locked mode approximation. Interactions between incident and scattered wavefields are prescribed by mode coupling theory and account for the coupling among surface waves, body waves, and evanescent waves. The described algorithm is, in principle, applicable to global and regional wave propagation problems, but I focus on higher frequency (typically f ??????0.25 Hz) applications at regional and local distances where the locked mode approximation is best utilized and which involve wavefields strongly shaped by propagation through a highly heterogeneous crust. Synthetic examples are shown for P-SV-wave propagation through a semi-ellipsoidal basin and SH-wave propagation through a fault zone.
Resource heterogeneity can facilitate cooperation.
Kun, Ádám; Dieckmann, Ulf
2013-01-01
Although social structure is known to promote cooperation, by locally exposing selfish agents to their own deeds, studies to date assumed that all agents have access to the same level of resources. This is clearly unrealistic. Here we find that cooperation can be maintained when some agents have access to more resources than others. Cooperation can then emerge even in populations in which the temptation to defect is so strong that players would act fully selfishly if their resources were distributed uniformly. Resource heterogeneity can thus be crucial for the emergence and maintenance of cooperation. We also show that resource heterogeneity can hinder cooperation once the temptation to defect is significantly lowered. In all cases, the level of cooperation can be maximized by managing resource heterogeneity.
Static heterogeneities in liquid water
NASA Astrophysics Data System (ADS)
Stanley, H. Eugene; Buldyrev, Sergey V.; Giovambattista, Nicolas
2004-10-01
The thermodynamic behavior of water seems to be closely related to static heterogeneities. These static heterogeneities are related to the local structure of water molecules, and when properly characterized, may offer an economical explanation of thermodynamic data. The key feature of liquid water is not so much that the existence of hydrogen bonds, first pointed out by Linus Pauling, but rather the local geometry of the liquid molecules is not spherical or oblong but tetrahedral. In the consideration of static heterogeneities, this local geometry is critical. Recent experiments suggested more than one phase of amorphous solid water, while simulations suggest that one of these phases is metastable with respect to another, so that in fact there are only two stable phases.
Simulator for heterogeneous dataflow architectures
NASA Technical Reports Server (NTRS)
Malekpour, Mahyar R.
1993-01-01
A new simulator is developed to simulate the execution of an algorithm graph in accordance with the Algorithm to Architecture Mapping Model (ATAMM) rules. ATAMM is a Petri Net model which describes the periodic execution of large-grained, data-independent dataflow graphs and which provides predictable steady state time-optimized performance. This simulator extends the ATAMM simulation capability from a heterogenous set of resources, or functional units, to a more general heterogenous architecture. Simulation test cases show that the simulator accurately executes the ATAMM rules for both a heterogenous architecture and a homogenous architecture, which is the special case for only one processor type. The simulator forms one tool in an ATAMM Integrated Environment which contains other tools for graph entry, graph modification for performance optimization, and playback of simulations for analysis.
40 CFR 86.244-94 - Calculations; exhaust emissions.
Code of Federal Regulations, 2011 CFR
2011-07-01
... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.244-94 Calculations; exhaust.... Should NOX measurements be calculated, note that the humidity correction factor is not valid at colder temperatures. Light-duty vehicles and light-duty trucks must calculate and report the weighted mass of...
Structures of medium-sized silicon clusters
NASA Astrophysics Data System (ADS)
Ho, Kai-Ming; Shvartsburg, Alexandre A.; Pan, Bicai; Lu, Zhong-Yi; Wang, Cai-Zhuang; Wacker, Jacob G.; Fye, James L.; Jarrold, Martin F.
1998-04-01
Silicon is the most important semiconducting material in the microelectronics industry. If current miniaturization trends continue, minimum device features will soon approach the size of atomic clusters. In this size regime, the structure and properties of materials often differ dramatically from those of the bulk. An enormous effort has been devoted to determining the structures of free silicon clusters. Although progress has been made for Sin with n < 8, theoretical predictions for larger clusters are contradictory and none enjoy any compelling experimental support. Here we report geometries calculated for medium-sized silicon clusters using an unbiased global search with a genetic algorithm. Ion mobilities determined for these geometries by trajectory calculations are in excellent agreement with the values that we measure experimentally. The cluster geometries that we obtain do not correspond to fragments of the bulk. For n = 12-18 they are built on a structural motif consisting of a stack of Si9 tricapped trigonal prisms. For n >= 19, our calculations predict that near-spherical cage structures become the most stable. The transition to these more spherical geometries occurs in the measured mobilities for slightly larger clusters than in the calculations, possibly because of entropic effects.
Heterogeneous photocatalytic reactions of sulfur aromatic compounds.
Samokhvalov, Alexander
2011-11-18
Sulfur aromatic compounds, such as mono-, di-, tri-, and tetraalkyl-substituted thiophene, benzothiophenes, dibenzothiophenes, are the molecular components of many fossils (petroleum, oil shale, tar sands, bitumen). Structural units of natural, cross-linked heteroaromatic polymers present in brown coals, turf, and soil are similar to those of sulfur aromatic compounds. Many sulfur aromatic compounds are found in the streams of petroleum refining and upgrading (naphthas, gas oils) and in the consumer products (gasoline, diesel, jet fuels, heating fuels). Besides fossils, the structural fragments of sulfur aromatic compounds are present in molecules of certain organic semiconductors, pesticides, small molecule drugs, and in certain biomolecules present in human body (pheomelanin pigments). Photocatalysis is the frontier area of physical chemistry that studies chemical reactions initiated by absorption of photons by photocatalysts, that is, upon electronic rather than thermal activation, under "green" ambient conditions. This review provides systematization and critical review of the fundamental chemical and physicochemical information on heterogeneous photocatalysis of sulfur aromatic compounds accumulated in the last 20-30 years. Specifically, the following topics are covered: physicochemical properties of sulfur aromatic compounds, major classes of heterogeneous photocatalysts, mechanisms and reactive intermediates of photocatalytic reactions of sulfur aromatic compounds, and the selectivity of these reactions. Quantum chemical calculations of properties and structures of sulfur aromatic compounds, their reactive intermediates, and the structure of adsorption complexes formed on the surface of the photocatalysts are also discussed.
OH initiated heterogeneous degradation of organophosphorus compounds
NASA Astrophysics Data System (ADS)
Liggio, J.; Liu, Y.; Harner, T.; Jantunen, L.; Shoeib, M.; Li, S.
2013-12-01
Organophosphorus compounds (OPs) have been extensively used worldwide as flame retardants, plasticizers, antifoaming agents, and additives because of their favorable physicochemical characteristics. The global consumption of OPs is likely to greatly increase due to the phasing out of bromine-containing flame retardants (BFRs) with OPs identified as possible substitutes. In most applications, OPs easily leach out of the material into the environment via volatilization, abrasion, and dissolution and have been observed widely in atmospheric particles even in polar regions. However, little is known about their atmospheric fate. The Canadian Chemicals Management Plan (CMP) has targeted OP FRs for risk assessment, including assessing stability and atmospheric transport potential of OP FRs and other priority chemicals that are associated primarily with particles. In the current study, OH initiated heterogeneous reaction kinetics of tris(1,3-dichloro-2-propyl) phosphate (TDCPP), tris-2-ethylhexyl-phosphate (TEHP), tris-2-butoxyethyl-phosphate (TBEP), and tri-phenyl phosphate (TPhP) coated on (NH4)2SO4 were investigated using a photo-chemical flow tube which was coupled to an Aerosol Mass Spectrometer (AMS) and Proton Transfer Reaction Mass Spectrometer (PTR-MS). second-order rate constants (k2) for the heterogeneous loss of TPhP, TEHP and TDCPP were (2.07×0.19)×10-12, (2.69×0.63)×10-12 and (9.22×0.92)×10-13 cm3 molecule-1 s-1, respectively, from which approximate atmospheric lifetimes were estimated to be 5.6 (5.2-6.0), 4.3 (3.5-5.6), and 12.6 (11.4-14.0) days. These results represent the first reported estimates of heterogeneous rate constants for these species, and suggest that particle bound OPEs will be highly persistent in the atmosphere, supporting the assumption that OPEs can undergo medium or long-range transport, as proposed on the basis of field measurements.
Verification of Internal Dose Calculations.
NASA Astrophysics Data System (ADS)
Aissi, Abdelmadjid
The MIRD internal dose calculations have been in use for more than 15 years, but their accuracy has always been questionable. There have been attempts to verify these calculations; however, these attempts had various shortcomings which kept the question of verification of the MIRD data still unanswered. The purpose of this research was to develop techniques and methods to verify the MIRD calculations in a more systematic and scientific manner. The research consisted of improving a volumetric dosimeter, developing molding techniques, and adapting the Monte Carlo computer code ALGAM to the experimental conditions and vice versa. The organic dosimetric system contained TLD-100 powder and could be shaped to represent human organs. The dosimeter possessed excellent characteristics for the measurement of internal absorbed doses, even in the case of the lungs. The molding techniques are inexpensive and were used in the fabrication of dosimetric and radioactive source organs. The adaptation of the computer program provided useful theoretical data with which the experimental measurements were compared. The experimental data and the theoretical calculations were compared for 6 source organ-7 target organ configurations. The results of the comparison indicated the existence of an agreement between measured and calculated absorbed doses, when taking into consideration the average uncertainty (16%) of the measurements, and the average coefficient of variation (10%) of the Monte Carlo calculations. However, analysis of the data gave also an indication that the Monte Carlo method might overestimate the internal absorbed doses. Even if the overestimate exists, at least it could be said that the use of the MIRD method in internal dosimetry was shown to lead to no unnecessary exposure to radiation that could be caused by underestimating the absorbed dose. The experimental and the theoretical data were also used to test the validity of the Reciprocity Theorem for heterogeneous
A theoretical analysis of colloid attachment and straining in chemically heterogeneous porous media
Technology Transfer Automated Retrieval System (TEKTRAN)
A balance of applied hydrodynamic (TH) and resisting adhesive (TA) torques was conducted over a chemically heterogeneous porous medium that contained random roughness of height hr to determine the fraction of the solid surface area that contributes to colloid immobilization (Sf*) under unfavorable a...
Polypeptide heterogeneity of hamster and calf fibronectins.
Pena, S D; Mills, G; Hughes, R C; Aplin, J D
1980-01-01
The adhesive glycoprotein fibronectin has been isolated from fresh hamster plasma by affinity chromatography on gelatin coupled to Sepharose beads by the method of Engvall & Ruoslahti [Int. J. Cancer (1979) 20, 1-5]. Polyacrylamide-gel electrophoresis of material heated in sodium dodecyl sulphate and 2-mercaptoethanol shows two prominent polypeptide subunits of approx. mol.wts. 215 000 and 200 000, with variable amounts of lower-molecular-weight fragments. The unexpected polypeptide heterogeneity of different preparations of hamster fibronectins and bovine serum fibronectin is shown to be partly an artefact and is generated during isolation and storage of purified fibronectin. Treatment of each hamster fibronectin subunit or a smaller fragment of approx. mol.wt. 140 000 with thermolysin or trypsin after radioiodination produces similar patterns of tyrpsine-containing peptides, indicating similar primary amino-acid sequences. Antibodies raised against the major subunits of hamster plasma fibronectin were coupled to Sepharose beads and used in conjunction with gelatin affinity chromatography to isolate fibronectins extracted with urea from baby-hamster kidney (BHK) cells and present in the long-term culture medium of these cells. The cell and medium fibronectins are similar to hamster plasma fibronectin in amino-acid and carbohydrate composition and also produce very similar peptide 'maps'. We conclude that the various forms of hamster fibronectins are structurally analogous in agreement with indistinguishable biological properties in mediating the substance adhesion of BKH cells [Pena & Hughes (1978) Cell Biol. Int. Rep. 3, 339-344]. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. Fig. 6. Fig. 7. PMID:7458916
Monte Carlo Code System for Electron (Positron) Dose Kernel Calculations.
CHIBANI, OMAR
1999-05-12
Version 00 KERNEL performs dose kernel calculations for an electron (positron) isotropic point source in an infinite homogeneous medium. First, the auxiliary code PRELIM is used to prepare cross section data for the considered medium. Then the KERNEL code simulates the transport of electrons and bremsstrahlung photons through the medium until all particles reach their cutoff energies. The deposited energy is scored in concentric spherical shells at a radial distance ranging from zero to twice the source particle range.
Heterogeneous Interactions of Acetaldehyde and Sulfuric Acid
NASA Technical Reports Server (NTRS)
Michelsen, R. R.; Ashbourn, S. F. M.; Iraci, L. T.
2004-01-01
The uptake of acetaldehyde [CH3CHO] by aqueous sulfuric acid has been studied via Knudsen cell experiments over ranges of temperature (210-250 K) and acid concentration (40-80 wt. %) representative of the upper troposphere. The Henry's law constants for acetaldehyde calculated from these data range from 6 x 10(exp 2) M/atm for 40 wt. % H2SO4 at 228 K to 2 x 10(exp 5) M/atm for 80 wt. % H2SO4 at 212 K. In some instances, acetaldehyde uptake exhibits apparent steady-state loss. The possible sources of this behavior, including polymerization, will be explored. Furthermore, the implications for heterogeneous reactions of aldehydes in sulfate aerosols in the upper troposphere will be discussed.
Li, Zhen-Xing; Xue, Wei; Guan, Bing-Tao; Shi, Fu-Bo; Shi, Zhang-Jie; Jiang, Hong; Yan, Chun-Hua
2013-02-01
Translation of homogeneous catalysis into heterogeneous catalysis is a promising solution to green and sustainable development in chemical industry. For this purpose, noble metal nanoparticles represent a new frontier in catalytic transformations. Many challenges remain for researchers to transform noble metal nanoparticles of heterogeneous catalytic active sites into ionic species of homogeneous catalytic active sites. We report here a successful design on translating homogeneous gold catalysis into a heterogeneous system with a clear understanding of the catalytic pathway. This study initiates a novel concept to immobilize a homogeneous catalyst based on electron transfer between supporting base and supported nanoparticles. Meanwhile, on the basis of theoretical calculation, it has deepened the understanding of the interactions between noble metal nanoparticles and the catalyst support.
A theoretical analysis of colloid attachment and straining in chemically heterogeneous porous media.
Bradford, Scott A; Torkzaban, Saeed; Shapiro, Alexander
2013-06-11
A balance of applied hydrodynamic (T(H)) and resisting adhesive (T(A)) torques was conducted over a chemically heterogeneous porous medium that contained random roughness of height h(r) to determine the fraction of the solid surface area that contributes to colloid immobilization (S(f)*) under unfavorable attachment conditions. This model considers resistance due to deformation and the horizontal component of the adhesive force (F(AT)), spatial variations in the pore scale velocity distribution, and the influence of hr on lever arms for T(H) and T(A). Values of S(f)* were calculated for a wide range of physicochemical properties to gain insight into mechanisms and factors influencing colloid immobilization. Colloid attachment processes were demonstrated to depend on solution ionic strength (IS), the colloid radius (r(c)), the Young's modulus (K), the amount of chemical heterogeneity (P+), and the Darcy velocity (q). Colloid immobilization was also demonstrated to occur on a rough surface in the absence of attachment. In this case, S(f)* depended on IS, r(c), the roughness fraction (f0), h(r), and q. Roughness tended to enhance T(A) and diminish T(H). Consequently, the effect of IS on S(f)* was enhanced by h(r) relative to attachment. In contrast, the effects of r(c) and q on S(f)* were diminished by hr in comparison to attachment. Colloid immobilization adjacent to macroscopic roughness locations shares many similarities to grain-grain contact points and may be viewed as a type of straining process. In general, attachment was more important for higher IS and variance in the secondary minimum, and for smaller r(c), q, and K, but diffusion decreased these values. Conversely, straining was dominant for the opposite conditions. Discrepancies in the literature on mechanisms of colloid retention are likely due to a lack of consideration of all of these factors.
Parallelizing N-Body Simulations on a Heterogeneous Cluster
NASA Astrophysics Data System (ADS)
Stenborg, T. N.
2009-10-01
This thesis evaluates quantitatively the effectiveness of a new technique for parallelising direct gravitational N-body simulations on a heterogeneous computing cluster. In addition to being an investigation into how a specific computational physics task can be optimally load balanced across the heterogeneity factors of a distributed computing cluster, it is also, more generally, a case study in effective heterogeneous parallelisation of an all-pairs programming task. If high-performance computing clusters are not designed to be heterogeneous initially, they tend to become so over time as new nodes are added, or existing nodes are replaced or upgraded. As a result, effective techniques for application parallelisation on heterogeneous clusters are needed if maximum cluster utilisation is to be achieved and is an active area of research. A custom C/MPI parallel particle-particle N-body simulator was developed, validated and deployed for this evaluation. Simulation communication proceeds over cluster nodes arranged in a logical ring and employs nonblocking message passing to encourage overlap of communication with computation. Redundant calculations arising from force symmetry given by Newton's third law are removed by combining chordal data transfer of accumulated forces with ring passing data transfer. Heterogeneity in node computation speed is addressed by decomposing system data across nodes in proportion to node computation speed, in conjunction with use of evenly sized communication buffers. This scheme is shown experimentally to have some potential in improving simulation performance in comparison with an even decomposition of data across nodes. Techniques for further heterogeneous cluster load balancing are discussed and remain an opportunity for further work.
Upstream reciprocity in heterogeneous networks.
Iwagami, Akio; Masuda, Naoki
2010-08-01
Many mechanisms for the emergence and maintenance of altruistic behavior in social dilemma situations have been proposed. Indirect reciprocity is one such mechanism, where other-regarding actions of a player are eventually rewarded by other players with whom the original player has not interacted. The upstream reciprocity (also called generalized indirect reciprocity) is a type of indirect reciprocity and represents the concept that those helped by somebody will help other unspecified players. In spite of the evidence for the enhancement of helping behavior by upstream reciprocity in rats and humans, theoretical support for this mechanism is not strong. In the present study, we numerically investigate upstream reciprocity in heterogeneous contact networks, in which the players generally have different number of neighbors. We show that heterogeneous networks considerably enhance cooperation in a game of upstream reciprocity. In heterogeneous networks, the most generous strategy, by which a player helps a neighbor on being helped and in addition initiates helping behavior, first occupies hubs in a network and then disseminates to other players. The scenario to achieve enhanced altruism resembles that seen in the case of the Prisoner's Dilemma game in heterogeneous networks.
Heterogeneous catalytic alcoholysis of benzonitrile
Kagarlitskii, A.D.; Dmumakaev, K.Kh.; Bekova, N.S.
1986-04-01
The authors investigate the possibility of the direct heterogeneous catalytic synthesis of ethylbenzoate from benzonitrile. The catalysts tested were oxides of aluminium, titanium, and vanadium. The main conversion product detected chromatographically was ethylbenzoate; benzaldehyde, benzamide, and benzanilide were also identified. Aluminium oxide was found to be the most effective catalyst.
Heterogeneity in the gingival fibromatoses.
Takagi, M; Yamamoto, H; Mega, H; Hsieh, K J; Shioda, S; Enomoto, S
1991-11-15
Forty-nine cases of isolated familial and idiopathic gingival fibromatoses, consisting of 12 cases from six families and 37 cases of idiopathic gingival fibromatosis, were reviewed. Pedigrees of five families revealed various penetrances and genetic heterogeneity as suggested by the presence of both autosomal dominant and autosomal recessive inheritances. Ultrastructurally, the lesions were composed of fibroblast-like cells and myofibroblast-like cells, with the former being the predominant cell type. The 267 cases of familial and idiopathic gingival fibromatoses were analyzed, and they with or without hypertrichosis, mental retardation, and/or epilepsy. These included 49 cases seen by the authors, 50 cases from the Japanese literature, and 168 cases from non-Japanese literature. Isolated gingival fibromatosis occurred more frequently after age of 12 years (P less than 0.0074). There was no significant difference in age of onset between generalized and localized forms of the idiopathic gingival fibromatosis. Gingival fibromatosis with hypertrichosis and mental retardation and/or epilepsy occurred frequently before 12 years (P less than 0.069). It has been shown that heterogeneity of the gingival fibromatosis is a result of either histologic heterogeneity, genetic heterogeneity, or a combination with other systemic disorders.
Social Capital and Community Heterogeneity
ERIC Educational Resources Information Center
Coffe, Hilde
2009-01-01
Recent findings indicate that more pronounced community heterogeneity is associated with lower levels of social capital. These studies, however, concentrate on specific aspects in which people differ (such as income inequality or ethnic diversity). In the present paper, we introduce the number of parties in the local party system as a more…
Teaching about Heterogeneous Response Models
ERIC Educational Resources Information Center
Murray, Michael P.
2014-01-01
Individuals vary in their responses to incentives and opportunities. For example, additional education will affect one person differently than another. In recent years, econometricians have given increased attention to such heterogeneous responses and to the consequences of such responses for interpreting regression estimates, especially…
Flammability of Heterogeneously Combusting Metals
NASA Technical Reports Server (NTRS)
Jones, Peter D.
1998-01-01
Most engineering materials, including some metals, most notably aluminum, burn in homogeneous combustion. 'Homogeneous' refers to both the fuel and the oxidizer being in the same phase, which is usually gaseous. The fuel and oxidizer are well mixed in the combustion reaction zone, and heat is released according to some relation like q(sub c) = delta H(sub c)c[((rho/rho(sub 0))]exp a)(exp -E(sub c)/RT), Eq. (1) where the pressure exponent a is usually close to unity. As long as there is enough heat released, combustion is sustained. It is useful to conceive of a threshold pressure beyond which there is sufficient heat to keep the temperature high enough to sustain combustion, and beneath which the heat is so low that temperature drains away and the combustion is extinguished. Some materials burn in heterogeneous combustion, in which the fuel and oxidizer are in different phases. These include iron and nickel based alloys, which burn in the liquid phase with gaseous oxygen. Heterogeneous combustion takes place on the surface of the material (fuel). Products of combustion may appear as a solid slag (oxide) which progressively covers the fuel. Propagation of the combustion melts and exposes fresh fuel. Heterogeneous combustion heat release also follows the general form of Eq.(1), except that the pressure exponent a tends to be much less than 1. Therefore, the increase in heat release with increasing pressure is not as dramatic as it is in homogeneous combustion. Although the concept of a threshold pressure still holds in heterogeneous combustion, the threshold is more difficult to identify experimentally, and pressure itself becomes less important relative to the heat transfer paths extant in any specific application. However, the constants C, a, and E(sub c) may still be identified by suitable data reduction from heterogeneous combustion experiments, and may be applied in a heat transfer model to judge the flammability of a material in any particular actual
Integrated Structural/Acoustic Modeling of Heterogeneous Panels
NASA Technical Reports Server (NTRS)
Bednarcyk, Brett, A.; Aboudi, Jacob; Arnold, Steven, M.; Pennline, James, A.
2012-01-01
A model for the dynamic response of heterogeneous media is presented. A given medium is discretized into a number of subvolumes, each of which may contain an elastic anisotropic material, void, or fluid, and time-dependent boundary conditions are applied to simulate impact or incident pressure waves. The full time-dependent displacement and stress response throughout the medium is then determined via an explicit solution procedure. The model is applied to simulate the coupled structural/acoustic response of foam core sandwich panels as well as aluminum panels with foam inserts. Emphasis is placed on the acoustic absorption performance of the panels versus weight and the effects of the arrangement of the materials and incident wave frequency.
Nonlocal reactive transport with physical, chemical, and biological heterogeneity
NASA Astrophysics Data System (ADS)
Hu, Bill X.; Cushman, John H.; Deng, Fei-Wen
When a natural porous medium is viewed from an eulerian perspective, incomplete characterization of the hydraulic conductivity, chemical reactivity, and biological activity leads to nonlocal constitutive theories, irrespective of whether the medium has evolving heterogeneity with fluctuations over all scales. Within this framework a constitutive theory involving nonlocal dispersive and convective fluxes and nonlocal sources/sinks is developed for chemicals undergoing random linear nonequilibrium reactions and random equilibrium first-order decay in a random conductivity field. The resulting transport equations are solved exactly in Fourier-Laplace space and then numerically inverted to real space. Mean concentration contours and various spatial moments are presented graphically for several covariance structures. 1997 Published by Elsevier Science Ltd. All rights reserved
Magnetic heterogeneity of biological systems.
Piruzyan, L A; Kuznetsov, A A; Chikov, V M
1980-01-01
In biological systems nonuniformity of magnetic susceptibility, magnetic heterogeneity, is a reflection of their physical-chemical and morphological heterogeneity, A characteristic value of heterogeneity is delta K approximately 10(-6)-10(-7) CGS units, a quantitative measurement of susceptibility of cells and other small objects, may give qualitatively new information about their life processes. Patterns and features of movement of small biological objects and liquids affected by magnetic forces were studied. A method was developed for measuring magnetic susceptibility of single microobjects based on observation of movement of the objects in a strong heterogeneous field with parameters (formula: see text) grad H2/2 approximately 10(9)-10(10) Oe2/cm. This method does not require knowing the distribution of the field along the path of movement of the particles, and does not require preliminary calibration. Movement of human erythrocytes, rat hepatocytes, and starch granules in liquids at a point of entry into a gap with the field was observed experimentally. With sufficiently large fields Ho approximately (1-2) x 10(4) Oe, the value of the magnetic force was enough to change the rate of sedimentation movement of the objects appreciably (up to stopping it). This made it possible to compute the value delta K for cells approximately 10(-7)-10(-8) CGS units and to obtain the value of K for starch granules (-0.80 x 10(-6) cGS units). In connection with the fact that sensitivity to gravity in plants is coupled with a disturbance of the intracellular starch granules under the influence of gravity, certain problems of stimulating the effect of gravity on plants by magnetic forces were studied. Noncontact force effect on magnetically heterogeneous biological objects is a promising instrument for biophysical studies.
The strength of heterogeneous volcanic rocks: A 2D approximation
NASA Astrophysics Data System (ADS)
Heap, Michael J.; Wadsworth, Fabian B.; Xu, Tao; Chen, Chong-feng; Tang, Chun'an
2016-06-01
Volcanic rocks typically contain heterogeneities in the form of crystals and pores. We investigate here the influence of such heterogeneity on the strength of volcanic rocks using an elastic damage mechanics model in which we numerically deform two-dimensional samples comprising low-strength elements representing crystals and zero-strength elements representing pores. These circular elements are stochastically generated so that there is no overlap in a medium representing the groundmass. Our modelling indicates that increasing the fraction of pores and/or crystals reduces the strength of volcanic rocks, and that increasing the pore fraction results in larger strength reductions than increasing the crystal fraction. The model also highlights an important weakening role for pore diameter, but finds that crystal diameter has a less significant influence for strength. To account for heterogeneity (pores and crystals), we propose an effective medium approach where we define an effective pore fraction ϕp‧ = Vp/(Vp + Vg) where Vp and Vg are the pore and groundmass fractions, respectively. Highly heterogeneous samples (containing high pore and/or crystal fractions) will therefore have high values of ϕp‧, and vice-versa. When we express our numerical samples (more than 200 simulations spanning a wide range of crystal and pore fractions) in terms of ϕp‧, we find that their strengths can be described by a single curve for a given pore diameter. To provide a predictive tool for the strength of heterogeneous volcanic rocks, we propose a modified version of 2D solution for the Sammis and Ashby (1986) pore-emanating crack model, a micromechanical model designed to estimate strength using microstructural attributes such as porosity, pore radius, and fracture toughness. The model, reformulated to include ϕp‧ (and therefore crystal fraction), captures the strength curves for our numerical simulations over a sample heterogeneity range relevant to volcanic systems. We find
NASA Astrophysics Data System (ADS)
Cherblanc, F.; Ahmadi, A.; Quintard, M.
2007-05-01
This paper deals with two-equation models describing solute transport in highly heterogeneous porous systems and more particularly dual permeability structures composed of high- and low-permeability regions. A macroscopic two-equation model has been previously proposed in the literature based on the volume averaging technique [Ahmadi A, Quintard M, Whitaker S. Transport in chemically and mechanically heterogeneous porous media V: two-equation model for solute transport with adsorption, Adv Water Resour 1998;22:59-86; Cherblanc F, Ahmadi A, Quintard M. Two-medium description of dispersion in heterogeneous porous media: calculation of macroscopic properties. Water Resour Res 2003;39(6):1154-73]. Through this theoretical upscaling method, both convection and dispersion mechanisms are taken into account in both regions, allowing one to deal with a large range of heterogeneous systems. In this paper, the numerical tools associated with this model are developed in order to test the theory by comparing macroscopic concentration fields to those obtained by Darcy-scale numerical experiments. The heterogeneous structures considered are made up of low-permeability nodules embedded in a continuous high-permeability region. Several permeability ratios are used, leading to very different macroscopic behaviours. Taking advantage of the Darcy-scale simulations, the role of convection and dispersion in the mass exchange between the two regions is investigated. Large-scale averaged concentration fields and elution curves are extracted from the Darcy-scale numerical experiments and compared to the theoretical predictions given by the two-equation model. Very good agreement is found between experimental and theoretical results. A permeability ratio around 100 presents a behaviour characteristic of "mobile-mobile" systems emphasizing the relevance of this two-equation description. Eventually, the theory is used to set-up a criterion for the existence of local equilibrium conditions
Adaptive heterogeneous multi-robot teams
Parker, L.E.
1998-11-01
This research addresses the problem of achieving fault tolerant cooperation within small- to medium-sized teams of heterogeneous mobile robots. The author describes a novel behavior-based, fully distributed architecture, called ALLIANCE, that utilizes adaptive action selection to achieve fault tolerant cooperative control in robot missions involving loosely coupled, largely independent tasks. The robots in this architecture possess a variety of high-level functions that they can perform during a mission, and must at all times select an appropriate action based on the requirements of the mission, the activities of other robots, the current environmental conditions, and their own internal states. Since such cooperative teams often work in dynamic and unpredictable environments, the software architecture allows the team members to respond robustly and reliably to unexpected environmental changes and modifications in the robot team that may occur due to mechanical failure, the learning of new skills, or the addition or removal of robots from the team by human intervention. After presenting ALLIANCE, the author describes in detail the experimental results of an implementation of this architecture on a team of physical mobile robots performing a cooperative box pushing demonstration. These experiments illustrate the ability of ALLIANCE to achieve adaptive, fault-tolerant cooperative control amidst dynamic changes in the capabilities of the robot team.
Lizard locomotion in heterogeneous granular media
NASA Astrophysics Data System (ADS)
Schiebel, Perrin; Goldman, Daniel
2014-03-01
Locomotion strategies in heterogeneous granular environments (common substrates in deserts), are relatively unexplored. The zebra-tailed lizard (C. draconoides) is a useful model organism for such studies owing to its exceptional ability to navigate a variety of desert habitats at impressive speed (up to 50 body-lengths per second) using both quadrapedal and bidepal gaits. In laboratory experiments, we challenge the lizards to run across a field of boulders (2.54 cm diameter glass spheres or 3.8 cm 3D printed spheres) placed in a lattice pattern and embedded in a loosely packed granular medium of 0.3 mm diameter glass particles. Locomotion kinematics of the lizard are recorded using high speed cameras, with and without the scatterers. The data reveals that unlike the lizard's typical quadrupedal locomotion using a diagonal gait, when scatterers are present the lizard is most successful when using a bipedal gait, with a raised center of mass (CoM). We propose that the kinematics of bipedal running in conjunction with the lizard's long toes and compliant hind foot are the keys to this lizard's successful locomotion in the presence of such obstacles. NSF PoLS
How snowpack heterogeneity affects diurnal streamflow timing
Lundquist, J.D.; Dettinger, M.D.
2005-01-01
Diurnal cycles of streamflow in snow-fed rivers can be used to infer the average time a water parcel spends in transit from the top of the snowpack to a stream gauge in the river channel. This travel time, which is measured as the difference between the hour of peak snowmelt in the afternoon and the hour of maximum discharge each day, ranges from a few hours to almost a full day later. Travel times increase with longer percolation times through deeper snowpacks, and prior studies of small basins have related the timing of a stream's diurnal peak to the amount of snow stored in a basin. However, in many larger basins the time of peak flow is nearly constant during the first half of the melt season, with little or no variation between years. This apparent self-organization at larger scales can be reproduced by employing heterogeneous observations of snow depths and melt rates in a model that couples porous medium flow through an evolving snowpack with free surface flow in a channel. Copyright 2005 by the American Geophysical Union.
Filiatrault, Marie-Lou; Chauny, Jean-Marc; Daoust, Raoul; Roy, Marie-Pier; Denis, Ronald; Lavigne, Gilles
2016-01-01
Study Objective: Opioids are associated with higher risk for ataxic breathing and sleep apnea. We conducted a systematic literature review and meta-analysis to assess the influence of long-term opioid use on the apnea-hypopnea and central apnea indices (AHI and CAI, respectively). Methods: A systematic review protocol (Cochrane Handbook guidelines) was developed for the search and analysis. We searched Embase, Medline, ACP Journal Club, and Cochrane Database up to November 2014 for three topics: (1) narcotics, (2) sleep apnea, and (3) apnea-hypopnea index. The outcome of interest was the variation in AHI and CAI in opioid users versus non-users. Two reviewers performed the data search and extraction, and disagreements were resolved by discussion. Results were combined by standardized mean difference using a random effect model, and heterogeneity was tested by χ2 and presented as I2 statistics. Results: Seven studies met the inclusion criteria, for a total of 803 patients with obstructive sleep apnea (OSA). We compared 2 outcomes: AHI (320 opioid users and 483 non-users) and 790 patients with CAI (315 opioid users and 475 non-users). The absolute effect size for opioid use was a small increased in apnea measured by AHI = 0.25 (95% CI: 0.02–0.49) and a medium for CAI = 0.45 (95% CI: 0.27–0.63). Effect consistency across studies was calculated, showing moderate heterogeneity at I2 = 59% and 29% for AHI and CAI, respectively. Conclusions: The meta-analysis results suggest that long-term opioid use in OSA patients has a medium effect on central sleep apnea. Citation: Filiatrault ML, Chauny JM, Daoust R, Roy MP, Denis R, Lavigne G. Medium increased risk for central sleep apnea but not obstructive sleep apnea in long-term opioid users: a systematic review and meta-analysis. J Clin Sleep Med 2016;12(4):617–625. PMID:26943709
The Role of Thermal Instability in Interstellar Medium
NASA Astrophysics Data System (ADS)
Inutsuka, Shu-Ichiro; Koyama, Hiroshi; Inoue, Tsuyoshi
2005-09-01
Our understanding on the physical processes in the transition between warm neutral medium (WNM) and cold neutral medium (CNM) is dramatically increased in the last few years. This article reviews the role of thermal instability in interstellar medium. First we explain the basic property of thermal instability in terms of linear stability analysis. Then we analyze the propagation of a shock wave into WNM or CNM by taking into account radiative heating/cooling, thermal conduction, and physical viscosity, in one-, two-, and three-dimensional magnetohydrodynamical simulations. The results show that the thermal instability in the post-shock gas produces high-density molecular cloudlets embedded in warm neutral medium. The molecular cloudlets have velocity dispersion which is supersonic with respect to the sound speed of the cold medium but is sub-sonic with respect to the warm medium. The dynamical evolution driven by thermal instability in the post-shock layer is an important basic process for the transition from warm gases to cold molecular gases, because the shock waves are frequently generated by supernovae in the Galaxy. The mechanism for maintaining the turbulent motion in two-phase medium is analyzed further by identifying the dynamical instability of the transition layer between WNM and CNM, that has analogy to Darrieus-Landau Instability of flame fronts and the corrugation instability of MHD slow shocks. Once the total column density of the ensemble of cold clouds becomes larger than the critical value (~ 1021cm-2), the two-phase medium is expected to become one phase medium with the cooling timescale. This process is not well understood and remains to be studied. Attempts to compare the numerical results of dynamical calculations with observation are suggested.
Properties of the nuclear medium.
Baldo, M; Burgio, G F
2012-02-01
We review our knowledge on the properties of the nuclear medium that have been studied, over many years, on the basis of many-body theory, laboratory experiments and astrophysical observations. Throughout the presentation particular emphasis is placed on the possible relationship and links between the nuclear medium and the structure of nuclei, including the limitations of such an approach. First we consider the realm of phenomenological laboratory data and astrophysical observations and the hints they can give on the characteristics that the nuclear medium should possess. The analysis is based on phenomenological models, that however have a strong basis on physical intuition and an impressive success. More microscopic models are also considered, and it is shown that they are able to give invaluable information on the nuclear medium, in particular on its equation of state. The interplay between laboratory experiments and astrophysical observations is particularly stressed, and it is shown how their complementarity enormously enriches our insights into the structure of the nuclear medium. We then introduce the nucleon-nucleon interaction and the microscopic many-body theory of nuclear matter, with a critical discussion about the different approaches and their results. The Landau-Fermi liquid theory is introduced and briefly discussed, and it is shown how fruitful it can be in discussing the macroscopic and low-energy properties of the nuclear medium. As an illustrative example, we discuss neutron matter at very low density, and it is shown how it can be treated within the many-body theory. The general bulk properties of the nuclear medium are reviewed to indicate at which stage of our knowledge we stand, taking into account the most recent developments both in theory and experiments. A section is dedicated to the pairing problem. The connection with nuclear structure is then discussed, on the basis of the energy density functional method. The possibility of linking
Properties of the nuclear medium
NASA Astrophysics Data System (ADS)
Baldo, M.; Burgio, G. F.
2012-02-01
We review our knowledge on the properties of the nuclear medium that have been studied, over many years, on the basis of many-body theory, laboratory experiments and astrophysical observations. Throughout the presentation particular emphasis is placed on the possible relationship and links between the nuclear medium and the structure of nuclei, including the limitations of such an approach. First we consider the realm of phenomenological laboratory data and astrophysical observations and the hints they can give on the characteristics that the nuclear medium should possess. The analysis is based on phenomenological models, that however have a strong basis on physical intuition and an impressive success. More microscopic models are also considered, and it is shown that they are able to give invaluable information on the nuclear medium, in particular on its equation of state. The interplay between laboratory experiments and astrophysical observations is particularly stressed, and it is shown how their complementarity enormously enriches our insights into the structure of the nuclear medium. We then introduce the nucleon-nucleon interaction and the microscopic many-body theory of nuclear matter, with a critical discussion about the different approaches and their results. The Landau-Fermi liquid theory is introduced and briefly discussed, and it is shown how fruitful it can be in discussing the macroscopic and low-energy properties of the nuclear medium. As an illustrative example, we discuss neutron matter at very low density, and it is shown how it can be treated within the many-body theory. The general bulk properties of the nuclear medium are reviewed to indicate at which stage of our knowledge we stand, taking into account the most recent developments both in theory and experiments. A section is dedicated to the pairing problem. The connection with nuclear structure is then discussed, on the basis of the energy density functional method. The possibility of linking
Vorticity and upscaled dispersion in 3D heterogeneous porous media
NASA Astrophysics Data System (ADS)
Di Dato, Mariaines; Chiogna, Gabriele; de Barros, Felipe; Bellin, Alberto; Fiori, Aldo
2015-04-01
Modeling flow in porous media is relevant for many environmental, energy and industrial applications. From an environmental perspective, the relevance of porous media flow becomes evident in subsurface hydrology. In general, flow in natural porous media is creeping, yet the large variability in the hydraulic conductivity values encountered in natural aquifers leads to highly heterogeneous flow fields. This natural variability in the conductivity field will affect both dilution rates of chemical species and reactive mixing. A physical consequence of this heterogeneity is also the presence of a various localized kinematical features such as straining, shearing and vorticity in aquifers, which will influence the shape of solute clouds and its fate and transport. This work aims in fundamentally characterizing the vorticity field in spatially heterogeneous flow fields as a function of their statistical properties in order to analyze the impact on transport processes. In our study, three-dimensional porous formations are constructed with an ensemble of N independent, non-overlapping spheroidal inclusions submerged into an homogeneous matrix, of conductivity K0. The inclusions are randomly located in a domain of volume W and are fully characterized by the geometry of spheroid (oblate or prolate), their conductivity K (random and drawn from a given probability density function fκ), the centroid location ¯x, the axes ratio e, the orientation of the rotational axis (α1,α2) and the volume w. Under the assumption of diluted medium, the flow problem is solved analitically by means of only two parameters: the conductivity contrast κ = K/K0 and the volume fraction n = Nw/W . Through the variation of these parameters of the problem, it is possible to approximate the structure of natural heterogeneous porous media. Using a random distribution of the orientation of the inclusions, we create media defined by the same global anisotropy f = Iz/Ix but different micro
Enhancing the Flexibility of TCP in Heterogeneous Network
Hui, Wang; Zhihui, Fan; Zheqing, Li; Xuhui, Wei
2016-01-01
Due to a set of constant initial values, the performance of conventional TCP drops significantly encountering heterogeneous network, showing low throughput and unfairness. This paper firstly demonstrates the chaotic character of TCP congestion control in heterogeneous network, especially the sensitivity to initial value. Inspired by merit of nature-inspired algorithm, a novel structure of TCP congestion control (IPPM, Internet Prey-Predator Model) is proposed. Parameters such as available link capacity(C), congestion window (W) and queue length (Q) are collected by IPPM, which calculates the max value of C according to the interacting relationship existing in C, W and Q, and IPPM initiates the TCP ssthresh with the calculated value. Plenty of simulation results show that the modified TCP can effectively avoid network congestion and packet loss. Besides, it holds high resource utilization, convergence speeds, fairness and stability. PMID:27657890
The dangers of heterogeneous network computing: heterogeneous networks considered harmful
Demmel, J.; Stanley, K.; Dongarra, J.; Hammarling, S.; Osstrouchov, S.
1996-12-31
This report addresses the issue of writing reliable numerical software for networks of heterogeneous computers. Much software has been written for distributed memory parallel computers and in principal such software could readily be ported to networks of machines, such as a collection of workstations connected by Ethernet, but if such a network is not homogeneous there are special challenges that need to be addressed. The symptoms can range from erroneous results returned without warning to deadlock. Some of the problems are straightforward to solve, but for others the solutions are not so obvious and indeed in some cases, such as the method of bisection which we shall discuss in the report, we have not yet decided upon a satisfactory solution that does not incur an unacceptable overhead. Making software robust on heterogeneous systems often requires additional communication. In this report we describe and illustrate the problems and, where possible, suggest solutions so that others may be aware of the potential pitfalls and either avoid them or, if that is not possible, ensure that their software is not used on heterogeneous networks.
Interaction of dynamic rupture with small-scale heterogeneities
NASA Astrophysics Data System (ADS)
Galis, Martin; Mai, P. Martin
2014-05-01
Broadband ground motion simulations, with frequencies up to 10Hz, are important for engineering purposes, in particular for seismic hazard assessment for critical facilities. One problem in such simulations is the generation of high frequency radiation emitted during the dynamic rupture process. Ad-hoc kinematic rupture characterizations can be tweaked through empirical models to radiate over the desired frequency range, but their physical consistency remains questionable. In contrast, for physically self-consistent dynamic rupture modeling, controlled by friction, material parameters and the adopted physical laws, the mechanism that may lead to appropriate high-frequency radiation require heterogeneity in friction, stress, or fault geometry (or even all three quantities) at unknown but small length scales. Dunham at al. (2011) studied dynamic rupture propagation on rough faults in 2D, and described how fault roughness excites high-frequency radiation. In our study, we focus on the interaction of the dynamic rupture with small-scale heterogeneities on planar faults in 3D. We study effects of the interaction of dynamic rupture with 1) small-scale heterogeneities in the medium (that is, randomized 3D wave speed and density variations), and 2) small-scale heterogeneities in the frictional parameters. Our numerical results show significant variations in rupture velocity or peak slip velocity if small-scale heterogeneities are present. This indicates that the dynamic rupture is sensitive to both types of spatial inhomogeneity. At the same time we observe that the resulting near-source seismic wave fields are not very sensitive to these rupture variations, indicating that wavefront healing effects may "simplify" the complex seismic radiation once the waves propagated several wave-lengths away from the fault.
Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium
NASA Astrophysics Data System (ADS)
Chayen, Naomi E.; Saridakis, Emmanuel; Sear, Richard P.
2006-01-01
The determination of high-resolution structures of proteins requires crystals of suitable quality. Because of the new impetus given to structural biology by structural genomics/proteomics, the problem of crystallizing proteins is becoming increasingly acute. There is therefore an urgent requirement for the development of new efficient methods to aid crystal growth. Nucleation is the crucial step that determines the entire crystallization process. Hence, the holy grail is to design a "universal nucleant," a substrate that induces the nucleation of crystals of any protein. We report a theory for nucleation on disordered porous media and its experimental testing and validation using a mesoporous bioactive gel-glass. This material induced the crystallization of the largest number of proteins ever crystallized using a single nucleant. The combination of the model and the experimental results opens up the scope for the rational design of nucleants, leading to alternative means of controlling crystallization. protein crystallization | phase diagram | microbatch | vapor diffusion
Steinmann, Casper; Kongsted, Jacob
2015-09-01
Theoretical prediction of transport and optical properties of protein-pigment complexes is of significant importance when aiming at understanding the structure-function relationship in such systems. Electronic energy transfer (EET) couplings represent a key property in this respect since such couplings provide important insight into the strength of interaction between photoactive pigments in protein-pigment complexes. Recently, attention has been payed to how the environment modifies or even controls the electronic couplings. To enable such theoretical predictions, a fully polarizable embedding model has been suggested (Curutchet, C., et al. J. Chem. Theory Comput., 2009, 5, 1838-1848). In this work, we further develop this computational model by extending it with an ab initio derived polarizable force field including higher-order multipole moments. We use this extended model to systematically examine three different ways of obtaining EET couplings in a heterogeneous medium ranging from use of the exact transition density to a point-dipole approximation. Several interesting observations are made, for example, the explicit use of transition densities in the calculation of the electronic couplings, and also when including the explicit environment contribution, can be replaced by a much simpler transition point charge description without comprising the quality of the model predictions. PMID:26575923
Steinmann, Casper; Kongsted, Jacob
2015-09-01
Theoretical prediction of transport and optical properties of protein-pigment complexes is of significant importance when aiming at understanding the structure-function relationship in such systems. Electronic energy transfer (EET) couplings represent a key property in this respect since such couplings provide important insight into the strength of interaction between photoactive pigments in protein-pigment complexes. Recently, attention has been payed to how the environment modifies or even controls the electronic couplings. To enable such theoretical predictions, a fully polarizable embedding model has been suggested (Curutchet, C., et al. J. Chem. Theory Comput., 2009, 5, 1838-1848). In this work, we further develop this computational model by extending it with an ab initio derived polarizable force field including higher-order multipole moments. We use this extended model to systematically examine three different ways of obtaining EET couplings in a heterogeneous medium ranging from use of the exact transition density to a point-dipole approximation. Several interesting observations are made, for example, the explicit use of transition densities in the calculation of the electronic couplings, and also when including the explicit environment contribution, can be replaced by a much simpler transition point charge description without comprising the quality of the model predictions.
Composite catalyst surfaces: Effect of inert and active heterogeneities on pattern formation
Baer, M.; Bangia, A.K.; Kevrekidis, I.G.; Haas, G.; Rotermund, H.H.; Ertl, G.
1996-12-05
Spatiotemporal dynamics in reaction-diffusion systems can be altered through the properties (reactivity, diffusivity) of the medium in which they occur. We construct active heterogeneous media (composite catalytic surfaces with inert as well as active illusions) using microelectronics fabrication techniques and study the spatiotemporal dynamics of heterogeneous catalytic reactions on these catalysts. In parallel, we perform simulations as well as numerical stability and bifurcation analysis of these patterns using mechanistic models. At the limit of large heterogeneity `grain size` (compared to the wavelength of spontaneously arising structures) the interaction patterns with inert or active boundaries dominates (e.g., pinning, transmission, and boundary breakup of spirals, interaction of pulses with corners, `pacemaker` effects). At the opposite limit of very small or very finely distributed heterogeneity, effective behavior is observed (slight modulation of pulses, nearly uniform oscillations, effective spirals). Some representative studies of transitions between the two limits are presented. 48 refs., 11 figs.
Distillation Calculations with a Programmable Calculator.
ERIC Educational Resources Information Center
Walker, Charles A.; Halpern, Bret L.
1983-01-01
Describes a three-step approach for teaching multicomponent distillation to undergraduates, emphasizing patterns of distribution as an aid to understanding the separation processes. Indicates that the second step can be carried out by programmable calculators. (A more complete set of programs for additional calculations is available from the…
Elastic Waves Green Functions For Stratified Medium
NASA Astrophysics Data System (ADS)
Albuquerque, E. L.; Ferreira, E. C.; Mauriz, P. W.
Multiple scattering analysis of elastic waves propagating in a stratified medium is a powerful method to model seismic reflection signals, widely used in the exploration for oil and gas reservoirs. Reflection imaging and inversion method derive their exis- tence from the presence of singularities in the Earth's material properties that support the waves. Considering a Green's function formalism based on the {it frequency distri- bution} of the elastic wave spectra, we study their propagation within a model in which the Earth is treated as a stratified medium. The calculations are based on the linear response function approach, which is very convenient to deal with this kind of prob- lem. Both the displacement ({it space}) and the wavevector ({it space-time}) Green's functions are determined. A damping term gamma is included in a phenomenolog- ical way into the wavevector expression. In order to examine the waves' excitation, we also determine, by using the fluctuation-dissipation theorem, their power spectra, which have many interesting properties.
Formation of benzene in the interstellar medium
Jones, Brant M.; Zhang, Fangtong; Kaiser, Ralf I.; Jamal, Adeel; Mebel, Alexander M.; Cordiner, Martin A.; Charnley, Steven B.
2011-01-01
Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block—the aromatic benzene molecule—has remained elusive for decades. Here we demonstrate in crossed molecular beam experiments combined with electronic structure and statistical calculations that benzene (C6H6) can be synthesized via the barrierless, exoergic reaction of the ethynyl radical and 1,3-butadiene, C2H + H2CCHCHCH2 → C6H6 + H, under single collision conditions. This reaction portrays the simplest representative of a reaction class in which aromatic molecules with a benzene core can be formed from acyclic precursors via barrierless reactions of ethynyl radicals with substituted 1,3-butadiene molecules. Unique gas-grain astrochemical models imply that this low-temperature route controls the synthesis of the very first aromatic ring from acyclic precursors in cold molecular clouds, such as in the Taurus Molecular Cloud. Rapid, subsequent barrierless reactions of benzene with ethynyl radicals can lead to naphthalene-like structures thus effectively propagating the ethynyl-radical mediated formation of aromatic molecules in the interstellar medium. PMID:21187430
Formation of benzene in the interstellar medium.
Jones, Brant M; Zhang, Fangtong; Kaiser, Ralf I; Jamal, Adeel; Mebel, Alexander M; Cordiner, Martin A; Charnley, Steven B
2011-01-11
Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block--the aromatic benzene molecule--has remained elusive for decades. Here we demonstrate in crossed molecular beam experiments combined with electronic structure and statistical calculations that benzene (C(6)H(6)) can be synthesized via the barrierless, exoergic reaction of the ethynyl radical and 1,3-butadiene, C(2)H + H(2)CCHCHCH(2) → C(6)H(6) + H, under single collision conditions. This reaction portrays the simplest representative of a reaction class in which aromatic molecules with a benzene core can be formed from acyclic precursors via barrierless reactions of ethynyl radicals with substituted 1,3-butadiene molecules. Unique gas-grain astrochemical models imply that this low-temperature route controls the synthesis of the very first aromatic ring from acyclic precursors in cold molecular clouds, such as in the Taurus Molecular Cloud. Rapid, subsequent barrierless reactions of benzene with ethynyl radicals can lead to naphthalene-like structures thus effectively propagating the ethynyl-radical mediated formation of aromatic molecules in the interstellar medium.
Medium Effects in Single Molecule Electronics
NASA Astrophysics Data System (ADS)
Higgins, Simon
2010-03-01
We use STM-based techniques for measuring the electrical properties of metal|molecule|metal junctions. For a family of molecules HS(CH2)6-Ar-(CH2)6SH (Ar = substituted benzene), we found that the single molecule conductances varied significantly with substituent, being higher for electron-donating substituents [1]. Later, we studied the effect of increasing conjugation on this system by examining oligothiophenes HS(CH2)6-[C4H4S]x-(CH2)6SH (x = 1, 2, 3, 5). We found that the conductances of junctions involving these molecules depended upon the medium in which the measurements were made. In fact, for x = 3, the conductance was two orders of magnitude higher in the presence of water than in anhydrous conditions [2]. This presentation will outline these studies, together with the results of transport calculations that rationalise these unusual findings, and will set the results in the context of existing literature on medium effects in single molecule conductance determinations. In collaboration with Edmund Leary and Richard Nichols, University of Liverpool; Colin Lambert, Iain Grace, and Chris Finch, University of Lancaster; and Wolfgang Haiss, University of Liverpool.
Formation of Benzene in the Interstellar Medium
NASA Technical Reports Server (NTRS)
Jones, Brant M.; Zhang, Fangtong; Kaiser, Ralf I.; Jamal, Adeel; Mebel, Alexander M.; Cordiner, Martin A.; Charnley, Steven B.; Crim, F. Fleming (Editor)
2010-01-01
Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block-the aromatic benzene molecule-has remained elusive for decades. Here we demonstrate in crossed molecular beam experiments combined with electronic structure and statistical calculations that benzene (C6H6) can be synthesized via the barrierless, exoergic reaction of the ethynyl radical and 1,3- butadiene, C2H + H2CCHCHCH2 --> C6H6, + H, under single collision conditions. This reaction portrays the simplest representative of a reaction class in which aromatic molecules with a benzene core can be formed from acyclic precursors via barrierless reactions of ethynyl radicals with substituted 1,3-butadlene molecules. Unique gas-grain astrochemical models imply that this low-temperature route controls the synthesis of the very first aromatic ring from acyclic precursors in cold molecular clouds, such as in the Taurus Molecular Cloud. Rapid, subsequent barrierless reactions of benzene with ethynyl radicals can lead to naphthalene-like structures thus effectively propagating the ethynyl-radical mediated formation of aromatic molecules in the interstellar medium.
Danoix, F; Danoix, R; Akre, J; Grellier, A; Delagnes, D
2011-12-01
A medium carbon martensitic steel containing nanometer scale secondary hardening carbides and intermetallic particles is investigated by field ion microscopy and atom probe tomography. The interaction between the concomitant precipitations of both types of particles is investigated. It is shown that the presence of the intermetallic phase affects the nucleation mechanism and the spatial distribution of the secondary hardening carbides, which shifts from heterogeneous on dislocations to heterogeneous on the intermetallic particles.
Heterogeneous, weakly coupled map lattices
NASA Astrophysics Data System (ADS)
Sotelo Herrera, M.^{a.} Dolores; San Martín, Jesús; Porter, Mason A.
2016-07-01
Coupled map lattices (CMLs) are often used to study emergent phenomena in nature. It is typically assumed (unrealistically) that each component is described by the same map, and it is important to relax this assumption. In this paper, we characterize periodic orbits and the laminar regime of type-I intermittency in heterogeneous weakly coupled map lattices (HWCMLs). We show that the period of a cycle in an HWCML is preserved for arbitrarily small coupling strengths even when an associated uncoupled oscillator would experience a period-doubling cascade. Our results characterize periodic orbits both near and far from saddle-node bifurcations, and we thereby provide a key step for examining the bifurcation structure of heterogeneous CMLs.
The structure of the interstellar medium
NASA Technical Reports Server (NTRS)
Bregman, Joel N.; Ashe, Gregory A.
1991-01-01
We have compared theoretical H I models to a large area H I channel map centered at 1 = 205 deg, b = 0 deg. One set of models were calculated in which uncorrelated clouds of H I populate space. Of the cloud models considered, which include 'Spitzer'-type clouds and the McKee-Ostriker formulation, none were able to reproduce the data successfully. In another class of models, holes and holes with shells permeate an otherwise continuous H I medium. Although not entirely successful, these models contain characteristics that are similar to the data. In order to reproduce the amplitude of the H I variations on angular scales of over 1 deg, the volume occupied by ionized gas must be less than 30 percent, in sharp conflict with the models that suggest that the volume of the ISM is dominated by hot gas.
The opacity of an expanding medium
NASA Astrophysics Data System (ADS)
Blinnikov, S. I.
1996-01-01
Based on heuristic arguments, Karp et al. (1977) derived their well-known expression for the line opacity that allows for the effect of expansion. We use the general solution and Hilbert-type asymptotic expansions of the Boltzmann equation for photons to derive an expression for this "expansion opacity" rigorously. The difference between our result and the published results on this subject is discussed, as is the applicability of the expression for the expansion opacity to calculations of radiative transfer in a comoving frame in the moment approximation. For the zeroth moment (i.e., the energy equation), there is no need to take the expansion effect into account, and the absorption coefficient can be averaged just as in the case of a static medium. We also show how to properly average the expansion opacity in the flux equation.
Code System for Radionuclide Migration Calculations.
1988-02-26
Version: 00 IONMIG is used to calculate the far-field transport of decaying radionuclides through a porous medium by diffusion and convection. It was specifically developed in support of the U. S. Subseabed Disposal program. For user specified velocity and temperature fields the convection-diffusion equation is solved in a sorbing porous medium. The sorption may be a function of species type, concentration, vertical position and local temperature. The formulation used is applicable to two-dimensional planar ormore » axisymmetric geometries. Zero flux conditions are assumed at all but the upper boundaries.« less
NASA GSFC Perspective on Heterogeneous Processing
NASA Technical Reports Server (NTRS)
Powell, Wesley A.
2016-01-01
This presentation provides an overview of NASA GSFC, our onboard processing applications, the applicability heterogeneous processing to these applications, and necessary developments to enable heterogeneous processing to be infused into our missions.
Sterpin, E.; Salvat, F.; Olivera, G.; Vynckier, S.
2009-05-15
The reliability of the convolution/superposition (C/S) algorithm of the Hi-Art tomotherapy system is evaluated by using the Monte Carlo model TomoPen, which has been already validated for homogeneous phantoms. The study was performed in three stages. First, measurements with EBT Gafchromic film for a 1.25x2.5 cm{sup 2} field in a heterogeneous phantom consisting of two slabs of polystyrene separated with Styrofoam were compared to simulation results from TomoPen. The excellent agreement found in this comparison justifies the use of TomoPen as the reference for the remaining parts of this work. Second, to allow analysis and interpretation of the results in clinical cases, dose distributions calculated with TomoPen and C/S were compared for a similar phantom geometry, with multiple slabs of various densities. Even in conditions of lack of lateral electronic equilibrium, overall good agreement was obtained between C/S and TomoPen results, with deviations within 3%/2 mm, showing that the C/S algorithm accounts for modifications in secondary electron transport due to the presence of a low density medium. Finally, calculations were performed with TomoPen and C/S of dose distributions in various clinical cases, from large bilateral head and neck tumors to small lung tumors with diameter of <3 cm. To ensure a ''fair'' comparison, identical dose calculation grid and dose-volume histogram calculator were used. Very good agreement was obtained for most of the cases, with no significant differences between the DVHs obtained from both calculations. However, deviations of up to 4% for the dose received by 95% of the target volume were found for the small lung tumors. Therefore, the approximations in the C/S algorithm slightly influence the accuracy in small lung tumors even though the C/S algorithm of the tomotherapy system shows very good overall behavior.
Temperature chaos and quenched heterogeneities
NASA Astrophysics Data System (ADS)
Barucca, Paolo; Parisi, Giorgio; Rizzo, Tommaso
2014-03-01
We present a treatable generalization of the Sherrington-Kirkpatrick (SK) model which introduces correlations in the elements of the coupling matrix through multiplicative disorder on the single variables and investigate the consequences on the phase diagram. We define a generalized qEA parameter and test the structural stability of the SK results in this correlated case evaluating the de Almeida-Thouless line of the model. As a main result we demonstrate the increase of temperature chaos effects due to heterogeneities.
Analyzing and modeling heterogeneous behavior
NASA Astrophysics Data System (ADS)
Lin, Zhiting; Wu, Xiaoqing; He, Dongyue; Zhu, Qiang; Ni, Jixiang
2016-05-01
Recently, it was pointed out that the non-Poisson statistics with heavy tail existed in many scenarios of human behaviors. But most of these studies claimed that power-law characterized diverse aspects of human mobility patterns. In this paper, we suggest that human behavior may not be driven by identical mechanisms and can be modeled as a Semi-Markov Modulated Process. To verify our suggestion and model, we analyzed a total of 1,619,934 records of library visitations (including undergraduate and graduate students). It is found that the distribution of visitation intervals is well fitted with three sections of lines instead of the traditional power law distribution in log-log scale. The results confirm that some human behaviors cannot be simply expressed as power law or any other simple functions. At the same time, we divided the data into groups and extracted period bursty events. Through careful analysis in different groups, we drew a conclusion that aggregate behavior might be composed of heterogeneous behaviors, and even the behaviors of the same type tended to be different in different period. The aggregate behavior is supposed to be formed by "heterogeneous groups". We performed a series of experiments. Simulation results showed that we just needed to set up two states Semi-Markov Modulated Process to construct proper representation of heterogeneous behavior.
Heterogeneous nucleation or homogeneous nucleation?
NASA Astrophysics Data System (ADS)
Liu, X. Y.
2000-06-01
The generic heterogeneous effect of foreign particles on three dimensional nucleation was examined both theoretically and experimentally. It shows that the nucleation observed under normal conditions includes a sequence of progressive heterogeneous processes, characterized by different interfacial correlation function f(m,x)s. At low supersaturations, nucleation will be controlled by the process with a small interfacial correlation function f(m,x), which results from a strong interaction and good structural match between the foreign bodies and the crystallizing phase. At high supersaturations, nucleation on foreign particles having a weak interaction and poor structural match with the crystallizing phase (f(m,x)→1) will govern the kinetics. This frequently leads to the false identification of homogeneous nucleation. Genuine homogeneous nucleation, which is the up-limit of heterogeneous nucleation, may not be easily achievable under gravity. In order to check these results, the prediction is confronted with nucleation experiments of some organic and inorganic crystals. The results are in excellent agreement with the theory.
Wave propagation through a random medium - The random slab problem
NASA Technical Reports Server (NTRS)
Acquista, C.
1978-01-01
The first-order smoothing approximation yields integral equations for the mean and the two-point correlation function of a wave in a random medium. A method is presented for the approximate solution of these equations that combines features of the eiconal approximation and of the Born expansion. This method is applied to the problem of reflection and transmission of a plane wave by a slab of a random medium. Both the mean wave and the covariance are calculated to determine the reflected and transmitted amplitudes and intensities.
Nucleon QCD sum rules in the instanton medium
Ryskin, M. G.; Drukarev, E. G. Sadovnikova, V. A.
2015-09-15
We try to find grounds for the standard nucleon QCD sum rules, based on a more detailed description of the QCD vacuum. We calculate the polarization operator of the nucleon current in the instanton medium. The medium (QCD vacuum) is assumed to be a composition of the small-size instantons and some long-wave gluon fluctuations. We solve the corresponding QCD sum rule equations and demonstrate that there is a solution with the value of the nucleon mass close to the physical one if the fraction of the small-size instantons contribution is w{sub s} ≈ 2/3.
Active microwave remote sensing of an anisotropic random medium layer
NASA Technical Reports Server (NTRS)
Lee, J. K.; Kong, J. A.
1985-01-01
A two-layer anisotropic random medium model has been developed to study the active remote sensing of the earth. The dyadic Green's function for a two-layer anisotropic medium is developed and used in conjunction with the first-order Born approximation to calculate the backscattering coefficients. It is shown that strong cross-polarization occurs in the single scattering process and is indispensable in the interpretation of radar measurements of sea ice at different frequencies, polarizations, and viewing angles. The effects of anisotropy on the angular responses of backscattering coefficients are also illustrated.
Investigating Population Heterogeneity With Factor Mixture Models
ERIC Educational Resources Information Center
Lubke, Gitta H.; Muthen, Bengt
2005-01-01
Sources of population heterogeneity may or may not be observed. If the sources of heterogeneity are observed (e.g., gender), the sample can be split into groups and the data analyzed with methods for multiple groups. If the sources of population heterogeneity are unobserved, the data can be analyzed with latent class models. Factor mixture models…
Autistic Savant Calendar Calculators.
ERIC Educational Resources Information Center
Patti, Paul J.
This study identified 10 savants with developmental disabilities and an exceptional ability to calculate calendar dates. These "calendar calculators" were asked to demonstrate their abilities, and their strategies were analyzed. The study found that the ability to calculate dates into the past or future varied widely among these calculators. Three…
The influence of relative sediment supply on riverine habitat heterogeneity
NASA Astrophysics Data System (ADS)
Yarnell, Sarah M.; Mount, Jeffrey F.; Larsen, Eric W.
2006-10-01
The diversity of aquatic habitats in streams is linked to physical processes that act at various spatial and temporal scales. Two components of many that contribute to creating habitat heterogeneity in streams are the interaction between sediment supply and transport capacity and the presence of local in-stream structures, such as large woody debris and boulders. Data from previously published flume and field studies and a new field study on tributaries to the South Yuba River in Nevada County, California, USA, were used to evaluate the relationship between habitat heterogeneity, local in-stream structural features and relative sediment supply. Habitat heterogeneity was quantified using spatial heterogeneity measures from the field of landscape ecology. Relative sediment supply, as expressed by the sediment supply/transport capacity ratio, which controls channel morphology and substrate textures, two key physical habitat characteristics, was quantified using a dimensionless bedload transport ratio, q*. Calculated q* values were plotted against an ecologically meaningful heterogeneity index, Shannon's Diversity Index, measured for each study reach, as well as the percent area of in-stream structural elements. The results indicate two potential mechanisms for how relative sediment supply may drive geomorphic diversity in natural river systems at the reach scale. When less mobile structural elements form a small proportion of the reach landscape, the supply/capacity ratio dictates the range of sediment textures and geomorphic features observed within the reach. In these settings, channels with a moderate relative sediment supply exhibit the highest textural and geomorphic diversity. In contrast, when less mobile structural elements are abundant, forced local scour and deposition creates high habitat heterogeneity, even in the presence of high relative sediment supply.
Advanced fiber information systems seed coat neps baseline response from diverse mediums
Technology Transfer Automated Retrieval System (TEKTRAN)
An extensive literature search has revealed that no papers have been published regarding selectivity calculation of the AFIS seed coat neps (SCN) determination over interfering material in cotton. A prerequisite to selectivity measurements is to identify suitable fiber medium(s) that give baseline ...
Wheat Transpiration Response to Soil Heterogeneity
NASA Astrophysics Data System (ADS)
Langensiepen, M.; Kupisch, M.; Cai, G.; Vanderborght, J.; Stadler, A.; Hüging, H.; Ewert, F.
2014-12-01
Measuring sap-flow in thin wheat tillers has been difficult so far due to technical difficulties associated with the application of the heat-balance method for this purpose. We developed a new method which solved this problem (Langensiepen et al. 2014) and applied it during four consecutive vegetation seasons for determining tiller transpiration rates in a wheat field with strong soil heterogeneity. The transpiration rates differed insignificantly between different field sections characterized by strong differences in physical soil conditions, regardless whether the crop was irrigated or supplied with variable rainwater. Tiller transpiration in a sheltered section was slightly reduced. Maximum leaf vapor conductance didn't differ among these different conditions, except under severe water stress conditions. Leaf water potential varied considerably during daily cycles under all circumstances. These responses are typical for plants with anisohydric behaviors which are characterized by small sensitivities of guard cells to critical leaf water potential thresholds and high photosynthetic productivity under absent or mild water stress. Recent studies conducted in Eucalyptus, tomato, and Arabidopsis plants have shown that the transition from mild to severe stress in anisohydric plants is marked by an increasing sensitivity of stomatal control to the transpiration rate. The results of this study demonstrate that this also seems to be the case for wheat. This practically implies that the parameterization of models calculating wheat canopy flux responses to soil heterogeneity patterns must not only account for the crop-type specific soil-vegetation pattern interaction under absent or mild stress, but also for additional mechanisms which kick in when water stress becomes severe. Langensiepen, M., Kupisch, M., Graf, A., Schmidt, M., Ewert, F. (2014) Improving the stem heat balance method for determining sap-flow in wheat. Agric. For. Met. 186: 34-42
Probabilistic models for reactive behaviour in heterogeneous condensed phase media
NASA Astrophysics Data System (ADS)
Baer, M. R.; Gartling, D. K.; DesJardin, P. E.
2012-02-01
This work presents statistically-based models to describe reactive behaviour in heterogeneous energetic materials. Mesoscale effects are incorporated in continuum-level reactive flow descriptions using probability density functions (pdfs) that are associated with thermodynamic and mechanical states. A generalised approach is presented that includes multimaterial behaviour by treating the volume fraction as a random kinematic variable. Model simplifications are then sought to reduce the complexity of the description without compromising the statistical approach. Reactive behaviour is first considered for non-deformable media having a random temperature field as an initial state. A pdf transport relationship is derived and an approximate moment approach is incorporated in finite element analysis to model an example application whereby a heated fragment impacts a reactive heterogeneous material which leads to a delayed cook-off event. Modelling is then extended to include deformation effects associated with shock loading of a heterogeneous medium whereby random variables of strain, strain-rate and temperature are considered. A demonstrative mesoscale simulation of a non-ideal explosive is discussed that illustrates the joint statistical nature of the strain and temperature fields during shock loading to motivate the probabilistic approach. This modelling is derived in a Lagrangian framework that can be incorporated in continuum-level shock physics analysis. Future work will consider particle-based methods for a numerical implementation of this modelling approach.
Medium Modification of Vector Mesons
Chaden Djalali, Michael Paolone, Dennis Weygand, Michael H. Wood, Rakhsha Nasseripour
2011-03-01
The theory of the strong interaction, Quantum Chromodynamics (QCD), has been remarkably successful in describing high-energy and short-distance-scale experiments involving quarks and gluons. However, applying QCD to low energy and large-distance scale experiments has been a major challenge. Various QCD-inspired models predict a partial restoration of chiral symmetry in nuclear matter with modifications of the properties of hadrons from their free-space values. Measurable changes such as a shift in mass and/or a change of width are predicted at normal nuclear density. Photoproduction of vector mesons off nuclei have been performed at different laboratories. The properties of the ρ, ω and φ mesons are investigated either directly by measuring their mass spectra or indirectly through transparency ratios. The latest results regarding medium modifications of the vector mesons in the nuclear medium will be discussed.
NASA Astrophysics Data System (ADS)
Nurlybek, A. Ispulov; Abdul, Qadir; M, A. Shah; Ainur, K. Seythanova; Tanat, G. Kissikov; Erkin, Arinov
2016-03-01
The thermoelastic wave propagation in a tetragonal syngony anisotropic medium of classes 4, 4/m having heterogeneity along z axis has been investigated by employing matrizant method. This medium has an axis of second-order symmetry parallel to z axis. In the case of the fourth-order matrix coefficients, the problems of wave refraction and reflection on the interface of homogeneous anisotropic thermoelastic mediums are solved analytically.
Frequency-dependent effective hydraulic conductivity of strongly heterogeneous media.
Caspari, E; Gurevich, B; Müller, T M
2013-10-01
The determination of the transport properties of heterogeneous porous rocks, such as an effective hydraulic conductivity, arises in a range of geoscience problems, from groundwater flow analysis to hydrocarbon reservoir modeling. In the presence of formation-scale heterogeneities, nonstationary flows, induced by pumping tests or propagating elastic waves, entail localized pressure diffusion processes with a characteristic frequency depending on the pressure diffusivity and size of the heterogeneity. Then, on a macroscale, a homogeneous equivalent medium exists, which has a frequency-dependent effective conductivity. The frequency dependence of the conductivity can be analyzed with Biot's equations of poroelasticity. In the quasistatic frequency regime of this framework, the slow compressional wave is a proxy for pressure diffusion processes. This slow compressional wave is associated with the out-of-phase motion of the fluid and solid phase, thereby creating a relative fluid-solid displacement vector field. Decoupling of the poroelasticity equations gives a diffusion equation for the fluid-solid displacement field valid in a poroelastic medium with spatial fluctuations in hydraulic conductivity. Then, an effective conductivity is found by a Green's function approach followed by a strong-contrast perturbation theory suggested earlier in the context of random dielectrics. This theory leads to closed-form expressions for the frequency-dependent effective conductivity as a function of the one- and two-point probability functions of the conductivity fluctuations. In one dimension, these expressions are consistent with exact solutions in both low- and high-frequency limits for arbitrary conductivity contrast. In 3D, the low-frequency limit depends on the details of the microstructure. However, the derived approximation for the effective conductivity is consistent with the Hashin-Shtrikman bounds.
Dose calculation for electron therapy
NASA Astrophysics Data System (ADS)
Gebreamlak, Wondesen T.
The dose delivered by electron beams has a complex dependence on the shape of the field; any field shaping shields, design of collimator systems, and energy of the beam. This complicated dependence is due to multiple scattering of the electron beam as the beam travels from the accelerator head to the patient. The dosimetry of only regular field shapes (circular, square, or rectangular) is well developed. However, most tumors have irregular shapes and their dosimetry is calculated by direct measurement. This is laborious and time consuming. In addition, error can be introduced during measurements. The lateral build up ratio method (LBR), which is based on the Fermi-Eyges multiple scattering theory, calculates the dosimetry of irregular electron beam shapes. The accuracy of this method depends on the function sigma r(r,E) (the mean square radial displacement of the electron beam in the medium) used in the calculation. This research focuses on improving the accuracy of electron dose calculations using lateral build up ratio method by investigating the properties of sigmar(r,E). The percentage depth dose curves of different circular cutouts were measured using four electron beam energies (6, 9, 12, and 15 MeV), four electron applicator sizes (6x6, 10x10, 14x14, and 20x20 cm), three source-surface distance values (100, 105, 110 cm). The measured percentage depth dose curves were normalized at a depth of 0.05 cm. Using the normalized depth dose, the lateral build up ratio curves were determined. Using the cutout radius and the lateral build up ratio values, sigmar(z,E) were determined. It is shown that the sigma value increases linearly with cutout size until the cutout radius reaches the equilibrium range of the electron beam. The sigma value of an arbitrary circular cutout was determined from the interpolation of sigma versus cutout curve. The corresponding LBR value of the circular cutout was determined using its radius and sigma values. The depth dose distribution of
Ganusov, Vitaly V
2008-01-01
Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo. Inferring these rates from labeling and delabeling curves has been subject to considerable debate with different groups suggesting different mathematical models for that purpose. We show that the three models that are most commonly used are in fact mathematically identical and differ only in their interpretation of the estimated parameters. By extending these previous models, we here propose a more mechanistic approach for the analysis of data from deuterium labeling experiments. We construct a model of 'kinetic heterogeneity' in which the total cell population consists of many sub-populations with different rates of cell turnover. In this model, for a given distribution of the rates of turnover, the predicted fraction of labeled DNA accumulated and lost can be calculated. Our model reproduces several previously made experimental observations, such as a negative correlation between the length of the labeling period and the rate at which labeled DNA is lost after label cessation. We demonstrate the reliability of the new explicit kinetic heterogeneity model by applying it to artificially generated datasets, and illustrate its usefulness by fitting experimental data. In contrast to previous models, the explicit kinetic heterogeneity model (1) provides a mechanistic way of interpreting labeling data; (2) allows for a non-exponential loss of labeled cells during delabeling, and (3) can be used to describe data with variable labeling length.
Gao, Kai; Chung, Eric T.; Gibson, Richard L.; Fu, Shubin; Efendiev, Yalchin
2015-06-05
The development of reliable methods for upscaling fine scale models of elastic media has long been an important topic for rock physics and applied seismology. Several effective medium theories have been developed to provide elastic parameters for materials such as finely layered media or randomly oriented or aligned fractures. In such cases, the analytic solutions for upscaled properties can be used for accurate prediction of wave propagation. However, such theories cannot be applied directly to homogenize elastic media with more complex, arbitrary spatial heterogeneity. We therefore propose a numerical homogenization algorithm based on multiscale finite element methods for simulating elastic wave propagation in heterogeneous, anisotropic elastic media. Specifically, our method used multiscale basis functions obtained from a local linear elasticity problem with appropriately defined boundary conditions. Homogenized, effective medium parameters were then computed using these basis functions, and the approach applied a numerical discretization that is similar to the rotated staggered-grid finite difference scheme. Comparisons of the results from our method and from conventional, analytical approaches for finely layered media showed that the homogenization reliably estimated elastic parameters for this simple geometry. Additional tests examined anisotropic models with arbitrary spatial heterogeneity where the average size of the heterogeneities ranged from several centimeters to several meters, and the ratio between the dominant wavelength and the average size of the arbitrary heterogeneities ranged from 10 to 100. Comparisons to finite-difference simulations proved that the numerical homogenization was equally accurate for these complex cases.
Gao, Kai; Chung, Eric T.; Gibson, Richard L.; Fu, Shubin; Efendiev, Yalchin
2015-06-05
The development of reliable methods for upscaling fine scale models of elastic media has long been an important topic for rock physics and applied seismology. Several effective medium theories have been developed to provide elastic parameters for materials such as finely layered media or randomly oriented or aligned fractures. In such cases, the analytic solutions for upscaled properties can be used for accurate prediction of wave propagation. However, such theories cannot be applied directly to homogenize elastic media with more complex, arbitrary spatial heterogeneity. We therefore propose a numerical homogenization algorithm based on multiscale finite element methods for simulating elasticmore » wave propagation in heterogeneous, anisotropic elastic media. Specifically, our method used multiscale basis functions obtained from a local linear elasticity problem with appropriately defined boundary conditions. Homogenized, effective medium parameters were then computed using these basis functions, and the approach applied a numerical discretization that is similar to the rotated staggered-grid finite difference scheme. Comparisons of the results from our method and from conventional, analytical approaches for finely layered media showed that the homogenization reliably estimated elastic parameters for this simple geometry. Additional tests examined anisotropic models with arbitrary spatial heterogeneity where the average size of the heterogeneities ranged from several centimeters to several meters, and the ratio between the dominant wavelength and the average size of the arbitrary heterogeneities ranged from 10 to 100. Comparisons to finite-difference simulations proved that the numerical homogenization was equally accurate for these complex cases.« less
Feasibility of a Multigroup Deterministic Solution Method for 3D Radiotherapy Dose Calculations
Vassiliev, Oleg N.; Wareing, Todd A.; Davis, Ian M.; McGhee, John; Barnett, Douglas; Horton, John L.; Gifford, Kent; Failla, Gregory; Titt, Uwe; Mourtada, Firas
2008-01-01
Purpose To investigate the potential of a novel deterministic solver, Attila, for external photon beam radiotherapy dose calculations. Methods and Materials Two hypothetical cases for prostate and head and neck cancer photon beam treatment plans were calculated using Attila and EGSnrc Monte Carlo simulations. Open beams were modeled as isotropic photon point sources collimated to specified field sizes (100 cm SSD). The sources had a realistic energy spectrum calculated by Monte Carlo for a Varian Clinac 2100 operated in a 6MV photon mode. The Attila computational grids consisted of 106,000 elements, or 424,000 spatial degrees of freedom, for the prostate case, and 123,000 tetrahedral elements, or 492,000 spatial degrees of freedom, for the head and neck cases. Results For both cases, results demonstrate excellent agreement between Attila and EGSnrc in all areas, including the build-up regions, near heterogeneities, and at the beam penumbra. Dose agreement for 99% of the voxels was within 3% (relative point-wise difference) or 3mm distance-to-agreement criterion. Localized differences between the Attila and EGSnrc results were observed at bone and soft tissue interfaces, and are attributable to the effect of voxel material homogenization in calculating dose-to-medium in EGSnrc. For both cases, Attila calculation times were under 20 CPU minutes on a single 2.2 GHz AMD Opteron processor. Conclusions The methods in Attila have the potential to be the basis for an efficient dose engine for patient specific treatment planning, providing accuracy similar to that obtained by Monte Carlo. PMID:18722273
Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthma.
Downie, Sue R; Salome, Cheryl M; Verbanck, Sylvia; Thompson, Bruce R; Berend, Norbert; King, Gregory G
2013-03-15
The forced oscillation technique (FOT) and multiple-breath nitrogen washout (MBNW) are noninvasive tests that are potentially sensitive to peripheral airways, with MBNW indexes being especially sensitive to heterogeneous changes in ventilation. The objective was to study methacholine-induced changes in the lung periphery of asthmatic patients and determine how changes in FOT variables of respiratory system reactance (Xrs) and resistance (Rrs) and frequency dependence of resistance (Rrs5-Rrs19) can be linked to changes in ventilation heterogeneity. The contributions of air trapping and airway closure, as extreme forms of heterogeneity, were also investigated. Xrs5, Rrs5, Rrs19, Rrs5-Rrs19, and inspiratory capacity (IC) were calculated from the FOT. Ventilation heterogeneity in acinar and conducting airways, and trapped gas (percent volume of trapped gas at functional residual capacity/vital capacity), were calculated from the MBNW. Measurements were repeated following methacholine. Methacholine-induced airway closure (percent change in forced vital capacity) and hyperinflation (change in IC) were also recorded. In 40 mild to moderate asthmatic patients, increase in Xrs5 after methacholine was predicted by increases in ventilation heterogeneity in acinar airways and forced vital capacity (r(2) = 0.37, P < 0.001), but had no correlation with ventilation heterogeneity in conducting airway increase or IC decrease. Increases in Rrs5 and Rrs5-Rrs19 after methacholine were not correlated with increases in ventilation heterogeneity, trapped gas, hyperinflation, or airway closure. Increased reactance in asthmatic patients after methacholine was indicative of heterogeneous changes in the lung periphery and airway closure. By contrast, increases in resistance and frequency dependence of resistance were not related to ventilation heterogeneity or airway closure and were more indicative of changes in central airway caliber than of heterogeneity. PMID:23372144
Desseroit, M; Cheze Le Rest, C; Tixier, F; Majdoub, M; Visvikis, D; Hatt, M; Guillevin, R; Perdrisot, R
2014-06-15
Purpose: Previous studies have shown that CT or 18F-FDG PET intratumor heterogeneity features computed using texture analysis may have prognostic value in Non-Small Cell Lung Cancer (NSCLC), but have been mostly investigated separately. The purpose of this study was to evaluate the potential added value with respect to prognosis regarding the combination of non-enhanced CT and 18F-FDG PET heterogeneity textural features on primary NSCLC tumors. Methods: One hundred patients with non-metastatic NSCLC (stage I–III), treated with surgery and/or (chemo)radiotherapy, that underwent staging 18F-FDG PET/CT images, were retrospectively included. Morphological tumor volumes were semi-automatically delineated on non-enhanced CT using 3D SlicerTM. Metabolically active tumor volumes (MATV) were automatically delineated on PET using the Fuzzy Locally Adaptive Bayesian (FLAB) method. Intratumoral tissue density and FDG uptake heterogeneities were quantified using texture parameters calculated from co-occurrence, difference, and run-length matrices. In addition to these textural features, first order histogram-derived metrics were computed on the whole morphological CT tumor volume, as well as on sub-volumes corresponding to fine, medium or coarse textures determined through various levels of LoG-filtering. Association with survival regarding all extracted features was assessed using Cox regression for both univariate and multivariate analysis. Results: Several PET and CT heterogeneity features were prognostic factors of overall survival in the univariate analysis. CT histogram-derived kurtosis and uniformity, as well as Low Grey-level High Run Emphasis (LGHRE), and PET local entropy were independent prognostic factors. Combined with stage and MATV, they led to a powerful prognostic model (p<0.0001), with median survival of 49 vs. 12.6 months and a hazard ratio of 3.5. Conclusion: Intratumoral heterogeneity quantified through textural features extracted from both CT and FDG PET
Peeling of elastic thin films on heterogeneous solids
NASA Astrophysics Data System (ADS)
Ponson, Laurent; Xia, Shuman; Ravichandran, Guruswamy; Bhattacharya, Kaushik
2010-03-01
Thin film adhesives have become increasingly important in various applications such as packaging and coating, and we benefit daily of their adhesion properties by using various kinds of tape. Here, we study the effect of heterogeneities on their peeling properties. From the theoretical side, we show how perturbations of the peeling front induced by heterogeneities of fracture energy at the film-substrate interface result in additional bending and stretching of the thin film. The energetical cost associated with these deformations is balanced by the wandering of the peeling front that takes advantage of area of lower interfacial fracture energy. This leads to various peeling front geometries that are calculated as a function of the landscape of fracture energy. These predictions are confronted with experimental measurements performed on a model system where we follow in real time the adhesion front during the peeling of an elastic thin film on a rigid substrate with controlled heterogeneous properties. A PDMS thin film produced by spin coating is peeled from a rigid solid on which patterns are designed by using a regular printer, taking advantage of the high adhesion energy of the ink-PDMS interface. The measured peeling front geometry is compared with the theoretical predictions and the toughening effect induced by the heterogeneities is finally discussed.
Measure of Landscape Heterogeneity by Agent-Based Methodology
NASA Astrophysics Data System (ADS)
Wirth, E.; Szabó, Gy.; Czinkóczky, A.
2016-06-01
With the rapid increase of the world's population, the efficient food production is one of the key factors of the human survival. Since biodiversity and heterogeneity is the basis of the sustainable agriculture, the authors tried to measure the heterogeneity of a chosen landscape. The EU farming and subsidizing policies (EEA, 2014) support landscape heterogeneity and diversity, nevertheless exact measurements and calculations apart from statistical parameters (standard deviation, mean), do not really exist. In the present paper the authors' goal is to find an objective, dynamic method that measures landscape heterogeneity. It is achieved with the so called agent-based modelling, where randomly dispatched dynamic scouts record the observed land cover parameters and sum up the features of a new type of land. During the simulation the agents collect a Monte Carlo integral as a diversity landscape potential which can be considered as the unit of the `greening' measure. As a final product of the ABM method, a landscape potential map is obtained that can serve as a tool for objective decision making to support agricultural diversity.
Electrostatic interaction of heterogeneously charged surfaces with semipermeable membranes.
Maduar, Salim R; Lobaskin, Vladimir; Vinogradova, Olga I
2013-01-01
In this paper we study the electrostatic interaction of a heterogeneously charged wall with a neutral semipermeable membrane. The wall consists of periodic stripes, where the charge density varies in one direction. The membrane is in contact with a bulk reservoir of an electrolyte solution and separated from the wall by a thin film of salt-free liquid. One type of ions (small counterions) permeates into the gap. This gives rise to a distance-dependent membrane potential, which translates into a repulsive electrostatic disjoining pressure due to an overlap of counterion clouds in the gap. To quantify it we use two complementary approaches. First, we propose a mean-field theory based on a linearized Poisson-Boltzmann equation and Fourier analysis. These calculations allow us to estimate the effect of a heterogeneous charge pattern at the wall on the induced heterogeneous membrane potential, and the value of the disjoining pressure as a function of the gap. Second, we perform Langevin dynamics simulations of the same system with explicit ions. The results of the two approaches are in good agreement with each other at low surface charges and small gaps, but differ due to nonlinearity at higher charges. These results demonstrate that a heterogeneity of the wall charge can lead to a huge reduction in the electrostatic repulsion, which could dramatically facilitate self-assembly in complex synthetic and biological systems.
Post-seismic relaxation theory on laterally heterogeneous viscoelastic model
Pollitz, F.F.
2003-01-01
Investigation was carried out into the problem of relaxation of a laterally heterogeneous viscoelastic Earth following an impulsive moment release event. The formal solution utilizes a semi-analytic solution for post-seismic deformation on a laterally homogeneous Earth constructed from viscoelastic normal modes, followed by application of mode coupling theory to derive the response on the aspherical Earth. The solution is constructed in the Laplace transform domain using the correspondence principle and is valid for any linear constitutive relationship between stress and strain. The specific implementation described in this paper is a semi-analytic discretization method which assumes isotropic elastic structure and a Maxwell constitutive relation. It accounts for viscoelastic-gravitational coupling under lateral variations in elastic parameters and viscosity. For a given viscoelastic structure and minimum wavelength scale, the computational effort involved with the numerical algorithm is proportional to the volume of the laterally heterogeneous region. Examples are presented of the calculation of post-seismic relaxation with a shallow, laterally heterogeneous volume following synthetic impulsive seismic events, and they illustrate the potentially large effect of regional 3-D heterogeneities on regional deformation patterns.
Root Patterns in Heterogeneous Soils
NASA Astrophysics Data System (ADS)
Dara, A.; Moradi, A. B.; Carminati, A.; Oswald, S. E.
2010-12-01
Heterogeneous water availability is a typical characteristic of soils in which plant roots grow. Despite the intrinsic heterogeneity of soil-plant water relations, we know little about the ways how plants respond to local environmental quality. Furthermore, increasing use of soil amendments as partial water reservoirs in agriculture calls for a better understanding of plant response to soil heterogeneity. Neutron radiography is a non-invasive imaging that is highly sensitive to water and root distribution and that has high capability for monitoring spatial and temporal soil-plant water relations in heterogeneous systems. Maize plants were grown in 25 x 30 x 1 cm aluminum slabs filled with sandy soil. On the right side of the compartments a commercial water absorbent (Geohumus) was mixed with the soil. Geohumus was distributed with two patterns: mixed homogeneously with the soil, and arranged as 1-cm diameter aggregates (Fig. 1). Two irrigation treatments were applied: sufficient water irrigation and moderate water stress. Neutron radiography started 10 days after planting and has been performed twice a day for one week. At the end of the experiment, the containers were opened, the root were removed and dry root weight in different soil segments were measured. Neutron radiography showed root growth tendency towards Geohumus treated parts and preferential water uptake from Geohumus aggregates. Number and length of fine lateral roots were lower in treated areas compared to the non-treated zone and to control soil. Although corn plants showed an overall high proliferation towards the soil water sources, they decreased production of branches and fine root when water was more available near the main root parts. However there was 50% higher C allocation in roots grown in Geohumus compartments, as derived by the relative dry weight of root. The preferential C allocation in treated regions was higher when plants grew under water stress. We conclude that in addition to the
Synchronization in growing heterogeneous media
NASA Astrophysics Data System (ADS)
Chen, W.; Cheng, S. C.; Avalos, E.; Drugova, O.; Osipov, G.; Lai, Pik-Yin; Chan, C. K.
2009-04-01
Synchronization of heterogeneous systems that consist of oscillatory and passive elements are studied in cardiac myocytes/fibroblasts co-cultures. It is found that beating clusters of cardiac myocytes surrounded by fibroblasts will be formed. The beatings of the cardiac myocyte clusters are not correlated at early times, but get synchronized as the cultures mature. This synchronization can be understood by a Kuramoto model with a time-increasing coupling strength. Our findings show that the growth of the coupling strength between clusters is linear, while the overall wave dynamics of the system is controlled by the passive fibroblast in the system which presumably is growing exponentially.
Cellulose conversion under heterogeneous catalysis.
Dhepe, Paresh L; Fukuoka, Atsushi
2008-01-01
In view of current problems such as global warming, high oil prices, food crisis, stricter environmental laws, and other geopolitical scenarios surrounding the use of fossil feedstocks and edible resources, the efficient conversion of cellulose, a non-food biomass, into energy, fuels, and chemicals has received much attention. The application of heterogeneous catalysis could allow researchers to develop environmentally benign processes that lead to selective formation of value-added products from cellulose under relatively mild conditions. This Minireview gives insight into the importance of biomass utilization, the current status of cellulose conversion, and further transformation of the primary products obtained.
Heterogeneous reaction mechanisms and kinetics relevant to the CVD of semiconductor materials
Creighton, J.R.; Coltrin, M.E.
1994-03-01
This report documents the state of the art in experimental and theoretical techniques for determining reaction mechanisms and chemical kinetics of heterogeneous reactions relevant to the chemical vapor deposition of semiconductor materials. It summarizes the most common ultra-high vacuum experimental techniques that are used and the types of rate information available from each. Several case studies of specific chemical systems relevant to the microelectronics industry are described. Theoretical methods for calculating heterogeneous reaction rate constants are also summarized.
40 CFR 86.244-94 - Calculations; exhaust emissions.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Calculations; exhaust emissions. 86.244-94 Section 86.244-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.244-94 Calculations;...
Calculation of drift seepage for alternative emplacementdesigns
Li, Guomin; Tsang, Chin-Fu; Birkholzer, Jens
1999-07-30
The calculations presented in this report are performed to obtain seepage rates into drift and boreholes for two alternative designs of drift and waste emplacement at Yucca Mountain. The two designs are defined according to the Scope of Work 14012021M1, activity 399621, drafted October 6, 1998, and further refined in a conference telephone call on October 13, 1998, between Mark Balady, Jim Blink, Rob Howard and Chin-Fu Tsang. The 2 designs considered are: (1) Design A--Horizontal boreholes 1.0 m in diameter on both sides of the drift, with each borehole 8 m long and inclined to the drift axis by 30 degrees. The pillar between boreholes, measured parallel to the drift axis, is 3.3 m. In the current calculations, a simplified model of an isolated horizontal borehole 8 m long will be simulated. The horizontal borehole will be located in a heterogeneous fracture continuum representing the repository layer. Three different realizations will be taken from the heterogeneous field, representing three different locations in the rock. Seepage for each realization is calculated as a function of the percolation flux. Design B--Vertical boreholes, 1.0 m in diameter and 8.0 m deep, drilled from the bottom of an excavated 8.0 m diameter drift. Again, the drift with the vertical borehole will be assumed to be located in a heterogeneous fracture continuum, representing the rock at the repository horizon. Two realizations are considered, and seepage is calculated for the 8-m drift with and without the vertical 1-m borehole at its bottom.
2016-09-01
Numeracy and calculation are key skills for nurses. As nurses are directly accountable for ensuring medicines are prescribed, dispensed and administered safely, they must be able to understand and calculate drug doses. PMID:27615351
Moment tensors of a dislocation in a porous medium
NASA Astrophysics Data System (ADS)
Wang, Zhi; Hu, Hengshan
2016-06-01
A dislocation can be represented by a moment tensor for calculating seismic waves. However, the moment tensor expression was derived in an elastic medium and cannot completely describe a dislocation in a porous medium. In this paper, effective moment tensors of a dislocation in a porous medium are derived. It is found that the dislocation is equivalent to two independent moment tensors, i.e., the bulk moment tensor acting on the bulk of the porous medium and the isotropic fluid moment tensor acting on the pore fluid. Both of them are caused by the solid dislocation as well as the fluid-solid relative motion corresponding to fluid injection towards the surrounding rocks (or fluid outflow) through the fault plane. For a shear dislocation, the fluid moment tensor is zero, and the dislocation is equivalent to a double couple acting on the bulk; for an opening dislocation or fluid injection, the two moment tensors are needed to describe the source. The fluid moment tensor only affects the radiated compressional waves. By calculating the ratio of the radiation fields generated by unit fluid moment tensor and bulk moment tensor, it is found that the fast compressional wave radiated by the bulk moment tensor is much stronger than that radiated by the fluid moment tensor, while the slow compressional wave radiated by the fluid moment tensor is several times stronger than that radiated by the bulk moment tensor.
Sugita, Shukei; Matsumoto, Takeo
2013-01-01
There is growing evidence of heterogeneous distribution of collagen fibers in the aortic wall. To investigate the effects of collagen microstructure on local aortic wall deformation, porcine thoracic aortas were sliced into 100 μm-thick sections perpendicular to their radial direction and stretched biaxially with a laboratory-made tensile tester under a microscope equipped with a birefringence imaging system. Strain tensor components were calculated from fluorescent images of the cell nuclei for each 50 × 50 μm² area. Retardance Ret and slow axis azimuth θ were measured as indices of collagen density and fiber direction, respectively. Aortic wall deformation was highly heterogeneous: standard deviations of strains were significantly larger, by 3-5 times, in aortic slices than in homogeneous silicone sheets. A significant negative correlation was found between maximum principal strain and Ret (R=-0.077), and a positive correlation between minimum principal strain direction and θ (R=0.345). These indicate that the aorta is less distensible in areas with higher collagen density and in the direction of collagen fiber alignment. Microscopic heterogeneity may induce heterogeneous responses of smooth muscle cells and have crucial effects on mechanical homeostasis in the aortic wall. PMID:24165548
Socially Aware Heterogeneous Wireless Networks
Kosmides, Pavlos; Adamopoulou, Evgenia; Demestichas, Konstantinos; Theologou, Michael; Anagnostou, Miltiades; Rouskas, Angelos
2015-01-01
The development of smart cities has been the epicentre of many researchers’ efforts during the past decade. One of the key requirements for smart city networks is mobility and this is the reason stable, reliable and high-quality wireless communications are needed in order to connect people and devices. Most research efforts so far, have used different kinds of wireless and sensor networks, making interoperability rather difficult to accomplish in smart cities. One common solution proposed in the recent literature is the use of software defined networks (SDNs), in order to enhance interoperability among the various heterogeneous wireless networks. In addition, SDNs can take advantage of the data retrieved from available sensors and use them as part of the intelligent decision making process contacted during the resource allocation procedure. In this paper, we propose an architecture combining heterogeneous wireless networks with social networks using SDNs. Specifically, we exploit the information retrieved from location based social networks regarding users’ locations and we attempt to predict areas that will be crowded by using specially-designed machine learning techniques. By recognizing possible crowded areas, we can provide mobile operators with recommendations about areas requiring datacell activation or deactivation. PMID:26110402
Groundwater pumping by heterogeneous users
NASA Astrophysics Data System (ADS)
Saak, Alexander E.; Peterson, Jeffrey M.
2012-08-01
Farm size is a significant determinant of both groundwater-irrigated farm acreage and groundwater-irrigation-application rates per unit land area. This paper analyzes the patterns of groundwater exploitation when resource users in the area overlying a common aquifer are heterogeneous. In the presence of user heterogeneity, the common resource problem consists of inefficient dynamic and spatial allocation of groundwater because it impacts income distribution not only across periods but also across farmers. Under competitive allocation, smaller farmers pump groundwater faster if farmers have a constant marginal periodic utility of income. However, it is possible that larger farmers pump faster if the Arrow-Pratt coefficient of relative risk-aversion is sufficiently decreasing in income. A greater farm-size inequality may either moderate or amplify income inequality among farmers. Its effect on welfare depends on the curvature properties of the agricultural output function and the farmer utility of income. Also, it is shown that a flat-rate quota policy that limits the quantity of groundwater extraction per unit land area may have unintended consequences for the income distribution among farmers.
Socially Aware Heterogeneous Wireless Networks.
Kosmides, Pavlos; Adamopoulou, Evgenia; Demestichas, Konstantinos; Theologou, Michael; Anagnostou, Miltiades; Rouskas, Angelos
2015-06-11
The development of smart cities has been the epicentre of many researchers' efforts during the past decade. One of the key requirements for smart city networks is mobility and this is the reason stable, reliable and high-quality wireless communications are needed in order to connect people and devices. Most research efforts so far, have used different kinds of wireless and sensor networks, making interoperability rather difficult to accomplish in smart cities. One common solution proposed in the recent literature is the use of software defined networks (SDNs), in order to enhance interoperability among the various heterogeneous wireless networks. In addition, SDNs can take advantage of the data retrieved from available sensors and use them as part of the intelligent decision making process contacted during the resource allocation procedure. In this paper, we propose an architecture combining heterogeneous wireless networks with social networks using SDNs. Specifically, we exploit the information retrieved from location based social networks regarding users' locations and we attempt to predict areas that will be crowded by using specially-designed machine learning techniques. By recognizing possible crowded areas, we can provide mobile operators with recommendations about areas requiring datacell activation or deactivation.
Heterogeneous Transmutation Sodium Fast Reactor
S. E. Bays
2007-09-01
The threshold-fission (fertile) nature of Am-241 is used to destroy this minor actinide by capitalizing upon neutron capture instead of fission within a sodium fast reactor. This neutron-capture and its subsequent decay chain leads to the breeding of even neutron number plutonium isotopes. A slightly moderated target design is proposed for breeding plutonium in an axial blanket located above the active “fast reactor” driver fuel region. A parametric study on the core height and fuel pin diameter-to-pitch ratio is used to explore the reactor and fuel cycle aspects of this design. This study resulted in both non-flattened and flattened core geometries. Both of these designs demonstrated a high capacity for removing americium from the fuel cycle. A reactivity coefficient analysis revealed that this heterogeneous design will have comparable safety aspects to a homogeneous reactor of comparable size. A mass balance analysis revealed that the heterogeneous design may reduce the number of fast reactors needed to close the current once-through light water reactor fuel cycle.
Socially Aware Heterogeneous Wireless Networks.
Kosmides, Pavlos; Adamopoulou, Evgenia; Demestichas, Konstantinos; Theologou, Michael; Anagnostou, Miltiades; Rouskas, Angelos
2015-01-01
The development of smart cities has been the epicentre of many researchers' efforts during the past decade. One of the key requirements for smart city networks is mobility and this is the reason stable, reliable and high-quality wireless communications are needed in order to connect people and devices. Most research efforts so far, have used different kinds of wireless and sensor networks, making interoperability rather difficult to accomplish in smart cities. One common solution proposed in the recent literature is the use of software defined networks (SDNs), in order to enhance interoperability among the various heterogeneous wireless networks. In addition, SDNs can take advantage of the data retrieved from available sensors and use them as part of the intelligent decision making process contacted during the resource allocation procedure. In this paper, we propose an architecture combining heterogeneous wireless networks with social networks using SDNs. Specifically, we exploit the information retrieved from location based social networks regarding users' locations and we attempt to predict areas that will be crowded by using specially-designed machine learning techniques. By recognizing possible crowded areas, we can provide mobile operators with recommendations about areas requiring datacell activation or deactivation. PMID:26110402
Dynamic Heterogeneity in Lipid Structures
NASA Astrophysics Data System (ADS)
Othon, Christina; Dadashvand, Neda
2015-03-01
We have characterized the temperature and pressure dependent scaling of dynamic heterogeneity in a homogenous liquid phase of a lipid monolayer using time-resolved fluorescence anisotropy (TRFA) microscopy. Rotational diffusion is far more sensitive to highly correlated motions than translational diffusion due to the enhanced influence of nearest neighbor interactions. Highly correlated motion results in regions of high-density, low mobility lipids, and low-density, high mobility lipids; and are observed as the bimodal distribution of rotational correlation times. For biological lipid membranes the presence of highly correlated motion will greatly influence the rates of protein sorting and self-assembly, as particles suspended in the fluid can become kinetically trapped. Rotational diffusion timescales (~ ns) are far shorter than the lifetime of dynamic clusters and lipid raft-like structures (~ 10 μs), and thus the distribution of rotational correlation times can provide critical insight into the presence of these structures. We have characterized rotational dynamic distributions for a variety of phosphocholine moieties, and found dynamics consistent with highly correlated motion. Using the proximity to the phase transition, and the scaling of the temperature dependence of the heterogeneity we apply theoretical models developed for other condensed matter systems help us define limits on the size and lifetime of dynamic clusters in lipid structures. corresponding author
Ground movement analysis based on stochastic medium theory.
Fei, Meng; Wu, Li-chun; Zhang, Jia-sheng; Deng, Guo-dong; Ni, Zhi-hui
2014-01-01
In order to calculate the ground movement induced by displacement piles driven into horizontal layered strata, an axisymmetric model was built and then the vertical and horizontal ground movement functions were deduced using stochastic medium theory. Results show that the vertical ground movement obeys normal distribution function, while the horizontal ground movement is an exponential function. Utilizing field measured data, parameters of these functions can be obtained by back analysis, and an example was employed to verify this model. Result shows that stochastic medium theory is suitable for calculating the ground movement in pile driving, and there is no need to consider the constitutive model of soil or contact between pile and soil. This method is applicable in practice. PMID:24701184
ERIC Educational Resources Information Center
Crow, Tracy, Ed.; Harris, Julia, Ed.
1997-01-01
This journal contains brief descriptions of calculator-active materials that were found using Resource Finder, the searchable online catalog of curriculum resources from the Eisenhower National Clearinghouse (ENC). It features both the calculators themselves and the activity books that are used with them. Among the calculators included are those…
ERIC Educational Resources Information Center
Threlfall, John
2002-01-01
Suggests that strategy choice is a misleading characterization of efficient mental calculation and that teaching mental calculation methods as a whole is not conducive to flexibility. Proposes an alternative in which calculation is thought of as an interaction between noticing and knowledge. Presents an associated teaching approach to promote…
Not simply more of the same: distinguishing between patient heterogeneity and parameter uncertainty.
Vemer, Pepijn; Goossens, Lucas M A; Rutten-van Mölken, Maureen P M H
2014-11-01
In cost-effectiveness (CE) Markov models, heterogeneity in the patient population is not automatically taken into account. We aimed to compare methods of dealing with heterogeneity on estimates of CE, using a case study in chronic obstructive pulmonary disease (COPD). We first present a probabilistic sensitivity analysis (PSA) in which we sampled only from distributions representing parameter uncertainty. This ignores any heterogeneity. Next, we explored heterogeneity by presenting results for subgroups, using a method that samples parameter uncertainty simultaneously with heterogeneity in a single-loop PSA. Finally, we distinguished parameter uncertainty from heterogeneity in a double-loop PSA by performing a nested simulation within each PSA iteration. Point estimates and uncertainty differed substantially between methods. The incremental CE ratio (ICER) ranged from € 4900 to € 13,800. The single-loop PSA led to a substantially different shape of the CE plane and an overestimation of the uncertainty compared with the other 3 methods. The CE plane for the double-loop PSA showed substantially less uncertainty and a stronger negative correlation between the difference in costs and the difference in effects compared with the other methods. This came at the cost of higher calculation times. Not accounting for heterogeneity, subgroup analysis and the double-loop PSA can be viable options, depending on the decision makers' information needs. The single-loop PSA should not be used in CE research. It disregards the fundamental differences between heterogeneity and sampling uncertainty and overestimates uncertainty as a result. PMID:25216723
Not simply more of the same: distinguishing between patient heterogeneity and parameter uncertainty.
Vemer, Pepijn; Goossens, Lucas M A; Rutten-van Mölken, Maureen P M H
2014-11-01
In cost-effectiveness (CE) Markov models, heterogeneity in the patient population is not automatically taken into account. We aimed to compare methods of dealing with heterogeneity on estimates of CE, using a case study in chronic obstructive pulmonary disease (COPD). We first present a probabilistic sensitivity analysis (PSA) in which we sampled only from distributions representing parameter uncertainty. This ignores any heterogeneity. Next, we explored heterogeneity by presenting results for subgroups, using a method that samples parameter uncertainty simultaneously with heterogeneity in a single-loop PSA. Finally, we distinguished parameter uncertainty from heterogeneity in a double-loop PSA by performing a nested simulation within each PSA iteration. Point estimates and uncertainty differed substantially between methods. The incremental CE ratio (ICER) ranged from € 4900 to € 13,800. The single-loop PSA led to a substantially different shape of the CE plane and an overestimation of the uncertainty compared with the other 3 methods. The CE plane for the double-loop PSA showed substantially less uncertainty and a stronger negative correlation between the difference in costs and the difference in effects compared with the other methods. This came at the cost of higher calculation times. Not accounting for heterogeneity, subgroup analysis and the double-loop PSA can be viable options, depending on the decision makers' information needs. The single-loop PSA should not be used in CE research. It disregards the fundamental differences between heterogeneity and sampling uncertainty and overestimates uncertainty as a result.
Assessing the scale of tumor heterogeneity by complete hierarchical segmentation of MRI
NASA Astrophysics Data System (ADS)
Gensheimer, Michael F.; Hawkins, Douglas S.; Ermoian, Ralph P.; Trister, Andrew D.
2015-02-01
In many cancers, intratumoral heterogeneity has been found in histology, genetic variation and vascular structure. We developed an algorithm to interrogate different scales of heterogeneity using clinical imaging. We hypothesize that heterogeneity of perfusion at coarse scale may correlate with treatment resistance and propensity for disease recurrence. The algorithm recursively segments the tumor image into increasingly smaller regions. Each dividing line is chosen so as to maximize signal intensity difference between the two regions. This process continues until the tumor has been divided into single voxels, resulting in segments at multiple scales. For each scale, heterogeneity is measured by comparing each segmented region to the adjacent region and calculating the difference in signal intensity histograms. Using digital phantom images, we showed that the algorithm is robust to image artifacts and various tumor shapes. We then measured the primary tumor scales of contrast enhancement heterogeneity in MRI of 18 rhabdomyosarcoma patients. Using Cox proportional hazards regression, we explored the influence of heterogeneity parameters on relapse-free survival. Coarser scale of maximum signal intensity heterogeneity was prognostic of shorter survival (p = 0.05). By contrast, two fractal parameters and three Haralick texture features were not prognostic. In summary, our algorithm produces a biologically motivated segmentation of tumor regions and reports the amount of heterogeneity at various distance scales. If validated on a larger dataset, this prognostic imaging biomarker could be useful to identify patients at higher risk for recurrence and candidates for alternative treatment.
Medium Modifications of Hadron Properties and Partonic Processes
Brooks, W. K.; Strauch, S.; Tsushima, K.
2011-06-01
Chiral symmetry is one of the most fundamental symmetries in QCD. It is closely connected to hadron properties in the nuclear medium via the reduction of the quark condensate
Medium Effects in Parton Distributions
William Detmold, Huey-Wen Lin
2011-12-01
A defining experiment of high-energy physics in the 1980s was that of the EMC collaboration where it was first observed that parton distributions in nuclei are non-trivially related to those in the proton. This result implies that the presence of the nuclear medium plays an important role and an understanding of this from QCD has been an important goal ever since Here we investigate analogous, but technically simpler, effects in QCD and examine how the lowest moment of the pion parton distribution is modified by the presence of a Bose-condensed gas of pions or kaons.
Vertical ascending electrophoresis of cells with a minimal stabilizing medium
NASA Technical Reports Server (NTRS)
Omenyi, S. N.; Snyder, R. S.
1983-01-01
Vertical fractionation of a mixture of fixed horse and human red blood cells layered over a stabilizing support medium was done to give a valid comparison with proposed space experiments. In particular, the effects of sample thickness and concentration on zone migration rate were investigated. Electrophoretic mobilities of horse and human cells calculated from zone migration rates were compatible with those obtained by microelectrophoresis. Complete cell separation was observed when low power and effective cooling were employed.
Hydromagnetic wave heating of the low-density interstellar medium
NASA Technical Reports Server (NTRS)
Ferriere, Katia M.; Zweibel, Ellen G.; Shull, J. Michael
1988-01-01
A simple model for supernova remnant sources of MHD waves is used to calculate the energy spectrum of waves in the intercloud medium and the heating rate resulting from their dissipation. Models of thermal phases of interstellar gas in ionization and thermal equilibrium are then constructed, and it is demonstrated that wave dissipation can be an important heating mechanism which can account for the observed high H I temperatures in low-density (intercloud) neutral gas.
A note on a selective agar medium for the enumeration of Flavobacterium species in water.
Flint, K P
1985-12-01
A selective nutrient agar medium containing kanamycin at 50 micrograms/ml was developed for the isolation and enumeration of yellow-pigmented colonies from the River Sowe, Coventry. Such organisms were shown to be members of the heterogeneous genus Flavobacterium. Typically, yellow pigmented colonies constituted less than 10% of the colonies on nutrient agar alone but up to 70% on nutrient agar plus kanamycin. This medium is a useful addition to the range of media available for the isolation and further ecological study of particular species of this important group of micro-organisms.
Dosimetric effect of tissue heterogeneity for 125I prostate implants
Oliveira, Susana Maria; Teixeira, Nuno José; Fernandes, Lisete; Teles, Pedro; Vaz, Pedro
2014-01-01
Aim To use Monte Carlo (MC) together with voxel phantoms to analyze the tissue heterogeneity effect in the dose distributions and equivalent uniform dose (EUD) for 125I prostate implants. Background Dose distribution calculations in low dose-rate brachytherapy are based on the dose deposition around a single source in a water phantom. This formalism does not take into account tissue heterogeneities, interseed attenuation, or finite patient dimensions effects. Tissue composition is especially important due to the photoelectric effect. Materials and methods The computed tomographies (CT) of two patients with prostate cancer were used to create voxel phantoms for the MC simulations. An elemental composition and density were assigned to each structure. Densities of the prostate, vesicles, rectum and bladder were determined through the CT electronic densities of 100 patients. The same simulations were performed considering the same phantom as pure water. Results were compared via dose–volume histograms and EUD for the prostate and rectum. Results The mean absorbed doses presented deviations of 3.3–4.0% for the prostate and of 2.3–4.9% for the rectum, when comparing calculations in water with calculations in the heterogeneous phantom. In the calculations in water, the prostate D90 was overestimated by 2.8–3.9% and the rectum D0.1cc resulted in dose differences of 6–8%. The EUD resulted in an overestimation of 3.5–3.7% for the prostate and of 7.7–8.3% for the rectum. Conclusions The deposited dose was consistently overestimated for the simulation in water. In order to increase the accuracy in the determination of dose distributions, especially around the rectum, the introduction of the model-based algorithms is recommended. PMID:25337412
Development of Channeled Flow in Partially Molten Medium
NASA Astrophysics Data System (ADS)
Takashima, S.; Kumagai, I.; Kurita, K.
2002-12-01
There exist two contrasting models as to the style of melt migration in the partially molten medium; homogeneous permeable flow on grain scale and heterogeneous localized one (channeled flow on larger scale than the grain scale). It is considered that the style evolves from the homogeneous flow to the heterogeneous one as the degree of melting increases, but the physics responsible for this flow organization is not yet clarified. Several models as to this process and the melt segregation are proposed based on numerical simulation, though the experimental verification is not given yet. Here we present simple experimental results on the flow organization. We utilized highly deformable transparent gel as the solid phase. Due to this high deformability the matrix composed of the gel is easy to vary its internal structure. We have conducted the following experiments; the gel (about 5mm in diameter) is mingled with methyl-cellulose solution (MS) with almost same density as the gel, 1.01g/cm3, packed in a rectangular parallelepiped case (2.4cm*18cm*14.4cm), and a compaction state is realized by covering with wire netting at the upper boundary. Gel fraction of this mixture system is controlled by changing the ratio of the gel to MS (about 100% to 60%). Glycerol solution (GS) with density of 1.2g/cm3 is poured at the upper boundary. This is a kind of Rayleigh-Taylor Instability and the dense GS flows downward through the mixture. The flow pattern of the GS is analyzed. A series of these procedures is carried out at various gel fractions (from about 100% to 60%), and how the flow style varies with the gel fraction is investigated. At median fraction of the gel about 80% to 70% the evolution from homogeneous permeable flow to heterogeneous localized flow was observed. At higher gel fraction, liquid phase flows as homogeneous permeable flow. Fragility of the solid frame is a most important factor for flow organization. The structure of the partially molten medium can be easily
How Does the Medium Affect the Message?
ERIC Educational Resources Information Center
Dommermuth, William P.
1974-01-01
This experimental comparison of the advertising effectiveness of television, movies, radio, and print finds no support for McLuhan's idea that television is a "cool" medium and movies are a "hot" medium. (RB)
Wave propagation in a medium with cavities
NASA Astrophysics Data System (ADS)
Adler, Pierre; Pazdniakou, Aliaksei
2016-04-01
The detection and imaging of cavities is still difficult, but it generates a lot of interest because of its potential applications. We have developed a code based on Lattice Springs and Lattice Boltzmann which can calculate wave propagation through a three dimensional composite medium. The theoretical background of these techniques will only be briefly addressed during the talk. The solid phase may have properties which are variable in space; the solid matrix may contain voids of arbitrary shapes which are filled or not with a mixture of air and water. In addition some of the voids may be empty. The surface of the ground is also arbitrary and it may be hilly. The source may be either a disturbance applied to a region of the solid phase or an overpressure applied to a particular cavity. In both cases, the disturbance and the overpressure can be arbitrary in time. Several sources can be simultaneously employed. Any region can be recorded, but a particular attention is paid to surface signals since they are the ones which are usually measured. The code is parallelized. Systematic applications of this tool have been done in order to analyse the response of a medium containing cavities to various signals. This complete parametric study has analyzed the most important parameters. The shape and the nature of the source have been addressed first; step functions of a limited or of an infinite duration have been studied and they are shown to result in simpler outputs than Ricker functions. The position of the source with respect to the ground surface has been varied. If it is deep, the reflection of the initial signal with the surface complicates the analysis of the surface measurements. The distance between the source and the cavity does not appear to be a critical parameter as long as the signal remains sufficiently large when it interacts with the cavity. Moreover, when this distance is large, the signal is transformed into a plane wave. The influence of the shape of the
Optimization of contaminant removal for heterogeneous systems by soil venting
Walton, J.C.; Casey, D.; Anker, C.; LeMone, D.
1996-12-31
The efficiency of remediation of vadose zone organic compounds can be enhanced by refinement of methods for soil venting and bioventing in complex heterogeneous systems. This can be accomplished by (a) identification of physical and chemical conditions (e.g., soil temperature, moisture content, flow rates) required for rapid contaminant removal rates, (b) precise engineering control of identified parameters in the subsurface, and (c) development of knowledge-based operational strategies providing greater removal efficiencies at low cost. One method with promise is to moderately heat and humidify the input/replacement air during venting. Initial calculations indicate that this strategy may be quite effective in enhancing remediation of heterogeneous systems with diffusional control of cleanup time.
The heterogeneous anti-radiation shield for spacecraft*
NASA Astrophysics Data System (ADS)
Telegin, S. V.; Draganyuk, O. N.
2016-04-01
The paper deals with modeling of elemental composition and properties of heterogeneous layers in multilayered shields to protect spacecraft onboard equipment from radiation emitted by the natural Earth’s radiation belt. This radiation causes malfunctioning of semiconductor elements in electronic equipment and may result in a failure of the spacecraft as a whole. We consider four different shield designs and compare them to the most conventional radiation-protective material for spacecraft - aluminum. Out of light and heavy chemical elements we chose the materials with high reaction cross sections and low density. The mass attenuation coefficient of boron- containing compounds is 20% higher than that of aluminum. Heterogeneous shields consist of three layers: a glass cloth, borated material, and nickel. With a protective shield containing heavy metal the output bremsstrahlung can be reduced. The amount of gamma rays that succeed to penetrate the shield is 4 times less compared to aluminum. The shields under study have the thicknesses of 5.95 and 6.2 mm. A comparative analysis of homogeneous and multilayered protective coatings of the same chemical composition has been performed. A heterogeneous protective shield has been found to be advantageous in weight and shielding properties over its homogeneous counterparts and aluminum. The dose characteristics and transmittance were calculated by the Monte Carlo method. The results of our study lead us to conclude that a three-layer boron carbide shield provides the most effective protection from radiation. This shield ensures twice as low absorbed dose and 4 times less the number of penetrated gamma-ray photons compared to its aluminum analogue. Moreover, a heterogeneous shield will have a weight 10% lighter than aluminum, with the same attenuation coefficient of the electron flux. Such heterogeneous shields can be used to protect spacecraft launched to geostationary orbit. Furthermore, a protective boron-containing and
Volkov, E M; Sabirova, A R; Nurullin, L F; Zefirov, A L
2006-12-01
Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemide, and removal of Cl(-) or Ca(2+) from the medium. Functional heterogeneity of electrogenic ionic pumps is hypothesized implying the existence of two components: "stationary" (not regulated extracellularly) and "regulatory" (controlled and directly related to active Cl(-) transfer). PMID:17603680
Coordinated Collaboration between Heterogeneous Distributed Energy Resources
Abdollahy, Shahin; Lavrova, Olga; Mammoli, Andrea
2014-01-01
A power distribution feeder, where a heterogeneous set of distributed energy resources is deployed, is examined by simulation. The energy resources include PV, battery storage, natural gas GenSet, fuel cells, and active thermal storage for commercial buildings. The resource scenario considered is one that may exist in a not too distant future. Two cases of interaction between different resources are examined. One interaction involves a GenSet used to partially offset the duty cycle of a smoothing battery connected to a large PV system. The other example involves the coordination of twenty thermal storage devices, each associated with a commercial building.more » Storage devices are intended to provide maximum benefit to the building, but it is shown that this can have a deleterious effect on the overall system, unless the action of the individual storage devices is coordinated. A network based approach is also introduced to calculate some type of effectiveness metric to all available resources which take part in coordinated operation. The main finding is that it is possible to achieve synergy between DERs on a system; however this required a unified strategy to coordinate the action of all devices in a decentralized way.« less
Shape-controlled nanostructures in heterogeneous catalysis.
Zaera, Francisco
2013-10-01
Nanotechnologies have provided new methods for the preparation of nanomaterials with well-defined sizes and shapes, and many of those procedures have been recently implemented for applications in heterogeneous catalysis. The control of nanoparticle shape in particular offers the promise of a better definition of catalytic activity and selectivity through the optimization of the structure of the catalytic active site. This extension of new nanoparticle synthetic procedures to catalysis is in its early stages, but has shown some promising leads already. Here, we survey the major issues associated with this nanotechnology-catalysis synergy. First, we discuss new possibilities associated with distinguishing between the effects originating from nanoparticle size versus those originating from nanoparticle shape. Next, we survey the information available to date on the use of well-shaped metal and non-metal nanoparticles as active phases to control the surface atom ensembles that define the catalytic site in different catalytic applications. We follow with a brief review of the use of well-defined porous materials for the control of the shape of the space around that catalytic site. A specific example is provided to illustrate how new selective catalysts based on shape-defined nanoparticles can be designed from first principles by using fundamental mechanistic information on the reaction of interest obtained from surface-science experiments and quantum-mechanics calculations. Finally, we conclude with some thoughts on the state of the field in terms of the advances already made, the future potentials, and the possible limitations to be overcome.
Kinnison, D.E.; Connell, P.S.
1996-02-27
Currently, there is a widespread search for additional heterogeneous reactions or combination of heterogeneous and homogeneous (gas-phase) reactions that could catalytically reduce ozone to observed levels. In 1992, Burley and Johnston proposed that nitrosyl sulfuric acid (NSA) NOHSO{sub 4}, is a promising heterogeneous reactant for activating HCl in sulfuric acid particles. They list several sources for producing it in the stratosphere and they carried out thermodynamic and chemical kinetic calculations at one stratospheric altitude and at one latitude. NSA has been overlooked in all previous stratospheric model calculations, even though it has been observed in stratospheric sulfate aerosols. This study makes large scale atmospheric model calculations to test the proposal by Burley and Johnston that a promising heterogeneous process for activating HCl in sulfuric acid particles is a catalytic coupled based on nitrosyl sulfuric acid (NSA). This mechanism is examined under non-volcanic and volcanic conditions representative of the recent eruption of Mt. Pinatubo. The calculations set firm limits on the range of kinetic parameters over which this heterogeneous processes would be important in the global ozone balance, and thus is a guide for where laboratory work is needed. In addition, they have derived a preliminary time-dependent integration (1980--1994) to represent the observed trend in ozone. Comparison between model-derived and the observed ozone trend will be compared.
Vassiliadis, P.; Kalapothaki, V.; Mavrommati, C.; Trichopoulos, D.
1984-01-01
The Rappaport-Vassiliadis enrichment medium (RV medium) in 10 ml quantities (RV/43 degrees C, 10 ml) inoculated with 0.1 ml of pre-enrichment medium (P medium) was found more efficient in the isolation of salmonellae from 409 pre-enriched samples (mainly meat products), than the original Rappaport medium incubated at 43 degrees C (R/43 degrees C) and the RV medium in 5 ml quantities (RV/43 degrees C, 5 ml) inoculated with 0.01 ml of P medium (P less than 0.001, in both instances). Therefore, the inoculum from pre-enriched foods should not be less than 0.1 ml in 10 ml of RV medium. The RV/43 degrees, 10 ml was also better (P less than 0.01) in detecting samples containing salmonellas than the original Rappaport medium incubated at 37 degrees C (R/37 degrees C, 10 ml) and the modification R25 of R medium incubated at 37 degrees C. The R25 modification was used in 10 ml quantities (R25/37 degrees C, 10 ml) inoculated with 0.1 ml of P medium and in 5 ml quantities (R25/37 degrees, 5 ml) inoculated with 0.01 ml of P medium. The last two R25 procedures were of the same efficiency in isolating salmonellas from meat products. PMID:6747286
Code of Federal Regulations, 2014 CFR
2014-10-01
... 49 Transportation 3 2014-10-01 2014-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines,...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 49 Transportation 3 2012-10-01 2012-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines,...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 49 Transportation 3 2011-10-01 2011-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines,...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 49 Transportation 3 2013-10-01 2013-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines,...
27 CFR 19.914 - Medium plants.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Medium plants. 19.914 Section 19.914 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Medium plants. Any person wishing to establish a medium plant shall make application for and obtain...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 3 2010-10-01 2010-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines,...
Weakly bound states in heterogeneous waveguides
NASA Astrophysics Data System (ADS)
Amore, Paolo; Fernández, Francisco M.; Hofmann, Christoph P.
2016-07-01
We study the spectrum of the Helmholtz equation in a two-dimensional infinite waveguide, containing a weak heterogeneity localized at an internal point, and obeying Dirichlet boundary conditions at its border. We use the variational theorem to derive the condition for which the lowest eigenvalue of the spectrum falls below the continuum threshold and a bound state appears, localized at the heterogeneity. We devise a rigorous perturbation scheme and derive the exact expression for the energy to third order in the heterogeneity.
Data Integration for Heterogenous Datasets
2014-01-01
Abstract More and more, the needs of data analysts are requiring the use of data outside the control of their own organizations. The increasing amount of data available on the Web, the new technologies for linking data across datasets, and the increasing need to integrate structured and unstructured data are all driving this trend. In this article, we provide a technical overview of the emerging “broad data” area, in which the variety of heterogeneous data being used, rather than the scale of the data being analyzed, is the limiting factor in data analysis efforts. The article explores some of the emerging themes in data discovery, data integration, linked data, and the combination of structured and unstructured data. PMID:25553272
Genetic heterogeneity of hepatocellular carcinoma
Unsal, H.; Isselbacher, K.J. ); Yakicier, C.; Marcais, C.; Ozturk, M. ); Kew, M. ); Volkmann, M. ); Zentgraf, H. )
1994-01-18
The authors studied 80 hepatocellular carcinomas from three continents for p53 gene (TP53) mutations and hepatitis B virus (HBV) sequences. p53 mutations were frequent in tumors from Mozambique but not in tumors from South Africa, China, and Germany. Independent of geographic origin, most tumors were positive for HBV sequences. X gene coding sequences of HBV were detected in 78% of tumors, whereas viral sequences in the surface antigen- and core antigen-encoding regions were present in less than 35% of tumors. These observations indicate that hepatocellular carcinomas are genetically heterogeneous. Mozambican-types of hepatocellular carcinomas are characterized by a high incidence of p53 mutations related to aflatoxins. In other tumors, the rarity of p53 mutations combined with the frequent presence of viral X gene coding sequences suggests a possible interference of HBV with the wild-type p53 function.
Mesoscale poroelasticity of heterogeneous media
NASA Astrophysics Data System (ADS)
Monfared, Siavash; Laubie, Hadrien; Radjai, Farhang; Pellenq, Roland; Ulm, Franz-Josef
Poroelastic behavior of heterogeneous media is revisited. Lattice Element Method (LEM) is used to model interaction between solid constituents due to a pressurized pore space. Exploring beyond mean-field based theories in continuum microporomechanics, local textural variations and its contribution to the global anisotropic poroelastic behavior of real multiphase porous media are captured. To this end, statistical distributions of mesoscale poroelastic coefficients from numerical simulations on X-ray microscopy scans of two different organic-rich shales with different microtextures are presented. The results are compared with predictions using mean-field based tools of continuum micromechanics. The textural dependency of strain localization and stress chain formation captured in this framework promises a powerful tool for modeling poroelastic response of complex porous composites and a path to incorporate local textural and elastic variations into a continuum description. Visiting Scientist, CNRS-MIT, MIT.
HETEROGENEOUS REBURNING BY MIXED FUELS
Wei-Yin Chen; Benson B. Gathitu
2005-01-14
Recent studies of heterogeneous reburning, i.e., reburning involving a coal-derived char, have elucidated its variables, kinetics and mechanisms that are valuable to the development of a highly efficient reburning process. Young lignite chars contain catalysts that not only reduce NO, but they also reduce HCN that is an important intermediate that recycles to NO in the burnout zone. Gaseous CO scavenges the surface oxides that are formed during NO reduction, regenerating the active sites on the char surface. Based on this mechanistic information, cost-effective mixed fuels containing these multiple features has been designed and tested in a simulated reburning apparatus. Remarkably high reduction of NO and HCN has been observed and it is anticipated that mixed fuel will remove 85% of NO in a three-stage reburning process.
Heterogeneous fuel for hybrid rocket
NASA Technical Reports Server (NTRS)
Stickler, David B. (Inventor)
1996-01-01
Heterogeneous fuel compositions suitable for use in hybrid rocket engines and solid-fuel ramjet engines, The compositions include mixtures of a continuous phase, which forms a solid matrix, and a dispersed phase permanently distributed therein. The dispersed phase or the matrix vaporizes (or melts) and disperses into the gas flow much more rapidly than the other, creating depressions, voids and bumps within and on the surface of the remaining bulk material that continuously roughen its surface, This effect substantially enhances heat transfer from the combusting gas flow to the fuel surface, producing a correspondingly high burning rate, The dispersed phase may include solid particles, entrained liquid droplets, or gas-phase voids having dimensions roughly similar to the displacement scale height of the gas-flow boundary layer generated during combustion.
Heterogeneous Reburning By Mixed Fuels
Anderson Hall
2009-03-31
Recent studies of heterogeneous reburning, i.e., reburning involving a coal-derived char, have elucidated its variables, kinetics and mechanisms that are valuable to the development of a highly efficient reburning process. Young lignite chars contain catalysts that not only reduce NO, but they also reduce HCN that is an important intermediate that recycles to NO in the burnout zone. Gaseous CO scavenges the surface oxides that are formed during NO reduction, regenerating the active sites on the char surface. Based on this mechanistic information, cost-effective mixed fuels containing these multiple features has been designed and tested in a simulated reburning apparatus. Remarkably high reduction of NO and HCN has been observed and it is anticipated that mixed fuel will remove 85% of NO in a three-stage reburning process.
ERIC Educational Resources Information Center
Björklund, Mikaela
2013-01-01
Finnish society, including the Swedish-medium school, has traditionally been considered linguistically and culturally homogeneous. During the last twenty years there has been a distinct development towards increasingly heterogeneous municipalities and schools, but with great local variations. The aim of his article is to present some teacher…
Evaporation from heterogeneous soil surfaces
NASA Astrophysics Data System (ADS)
Lehmann, P.; Or, D.
2009-04-01
Evaporation rate is a key process of water exchange between soil surfaces and atmosphere and is controlled by both atmospheric demand and soil hydraulic properties. Initially high evaporation rates are sustained by capillary-induced water flow from receding drying front to evaporating surface. In heterogeneous soils air invades preferentially coarse-textured regions whereas fine textured surface regions remain water saturated. We investigated experimentally and numerically effects of hydraulic coupling on drying rate of heterogeneous porous media. Laboratory experiments with vertical contrasts between fine (0.1-0.5 mm) and coarse sand (0.3-0.9 mm) showed that the period of high drying rate was extended compared to evaporation from homogeneous materials. Water flow from coarse material to supply water evaporated from fine textured surface was monitored by neutron radiography imaging. Due to the high hydraulic conductivity of the coarse material the viscous head loss could be neglected for flow distances analyzed in the experiments (< 600 mm). We proposed a model to explore effects of hydraulic coupling on evaporation for a wide range of soil textural classes at plot scale. When the drying front in the coarse reaches a certain characteristic depth (defined by the pore size distribution) no water evaporates from the coarse surface, yet, subsurface flow from coarse to the fine textured inclusion persists and feeds enhanced evaporation rate. Assuming energy input was not limiting, evaporation from the fine textured inclusion may increase to compensate reduction of evaporating surface. For loam or silt as inclusion in sandy material, water was extracted from regions with more than 10 m in distance before flow was limited by viscous effects. In case of clay inclusions the radius of water extraction was smaller due to enhanced viscous resistance. The findings of the numerical study can be applied as well to assess the effect of shrubs or compacted trafficked zones on the
Toward understanding and exploiting tumor heterogeneity
Alizadeh, Ash A; Aranda, Victoria; Bardelli, Alberto; Blanpain, Cedric; Bock, Christoph; Borowski, Christine; Caldas, Carlos; Califano, Andrea; Doherty, Michael; Elsner, Markus; Esteller, Manel; Fitzgerald, Rebecca; Korbel, Jan O; Lichter, Peter; Mason, Christopher E; Navin, Nicholas; Pe’er, Dana; Polyak, Kornelia; Roberts, Charles W M; Siu, Lillian; Snyder, Alexandra; Stower, Hannah; Swanton, Charles; Verhaak, Roel G W; Zenklusen, Jean C; Zuber, Johannes; Zucman-Rossi, Jessica
2016-01-01
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here. PMID:26248267
Toward understanding and exploiting tumor heterogeneity.
Alizadeh, Ash A; Aranda, Victoria; Bardelli, Alberto; Blanpain, Cedric; Bock, Christoph; Borowski, Christine; Caldas, Carlos; Califano, Andrea; Doherty, Michael; Elsner, Markus; Esteller, Manel; Fitzgerald, Rebecca; Korbel, Jan O; Lichter, Peter; Mason, Christopher E; Navin, Nicholas; Pe'er, Dana; Polyak, Kornelia; Roberts, Charles W M; Siu, Lillian; Snyder, Alexandra; Stower, Hannah; Swanton, Charles; Verhaak, Roel G W; Zenklusen, Jean C; Zuber, Johannes; Zucman-Rossi, Jessica
2015-08-01
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here. PMID:26248267
Learning Heterogeneous Hidden Markov Random Fields
Liu, Jie; Zhang, Chunming; Burnside, Elizabeth; Page, David
2014-01-01
Hidden Markov random fields (HMRFs) are conventionally assumed to be homogeneous in the sense that the potential functions are invariant across different sites. However in some biological applications, it is desirable to make HMRFs heterogeneous, especially when there exists some background knowledge about how the potential functions vary. We formally define heterogeneous HMRFs and propose an EM algorithm whose M-step combines a contrastive divergence learner with a kernel smoothing step to incorporate the background knowledge. Simulations show that our algorithm is effective for learning heterogeneous HMRFs and outperforms alternative binning methods. We learn a heterogeneous HMRF in a real-world study. PMID:25404989
RESEARCH NOTE: Propagators and Feynman diagrams for laterally heterogeneous elastic media
NASA Astrophysics Data System (ADS)
Park, Minkyu; Odom, Robert I.
2005-01-01
The propagator for coupled-mode elastic waves can be cast into a number of different representations, which emphasize particular aspects of the wave propagation in a laterally heterogeneous medium. One representation has the form of a generalized scattering operator and contains a quantity that can be interpreted as the lateral impedance. Another representation reduces naturally to the JWKB approximation for smoothly varying media with no mode coupling. The propagator solution for the fields in a laterally heterogeneous elastic medium with weak random boundary fluctuations leads naturally to the application of Feynman diagram techniques for the derivation of Dyson's equation and the Bethe-Salpeter equation for the propagator mean and covariance, respectively. The diagram techniques are reviewed and their utility for solution of random media elastic wave problems is demonstrated.
Naff, R.L.
1998-01-01
The late-time macrodispersion coefficients are obtained for the case of flow in the presence of a small-scale deterministic transient in a three-dimensional anisotropic, heterogeneous medium. The transient is assumed to affect only the velocity component transverse to the mean flow direction and to take the form of a periodic function. For the case of a highly stratified medium, these late-time macrodispersion coefficients behave largely as the standard coefficients used in the transport equation. Only in the event that the medium is isotropic is it probable that significant deviations from the standard coefficients would occur.
Sintered composite medium and filter
Bergman, Werner
1987-01-01
A particulate filter medium is formed of a sintered composite of 0.5 micron diameter quartz fibers and 2 micron diameter stainless steel fibers. A preferred composition is about 40 vol. % quartz and about 60 vol. % stainless steel fibers. The media is sintered at about 1100.degree. C. to bond the stainless steel fibers into a cage network which holds the quartz fibers. High filter efficiency and low flow resistance are provided by the smaller quartz fibers. High strength is provided by the stainless steel fibers. The resulting media has a high efficiency and low pressure drop similar to the standard HEPA media, with tensile strength at least four times greater, and a maximum operating temperature of about 550.degree. C. The invention also includes methods to form the composite media and a HEPA filter utilizing the composite media. The filter media can be used to filter particles in both liquids and gases.
Medium consumption in holographic memories.
Ayres, Mark R; McLeod, Robert R
2009-07-01
The dynamic range of holographic storage media is traditionally characterized in terms of M/#. However, this is a system parameter that assumes simple, uniform plane-wave holograms. Realistic architectures violate this assumption so that M/# measured with plane waves cannot be used to predict system diffraction efficiency. Thus, there currently is no systematic method predicting signal strength and medium consumption for holographic storage architectures a priori. We define a new material parameter, the modulation integral, M(I), and show how this may be used for dynamic range budgeting and diffraction efficiency prediction in complex storage systems. The method is illustrated by applying it to two architectures, collinear and angle polytopic, in order to estimate the M/# required for achieving a target storage density in the presence of empirical optical scatter noise.
Theory of interstellar medium diagnostics
NASA Technical Reports Server (NTRS)
Fahr, H. J.
1983-01-01
The theoretical interpretation of observed interplanetary resonance luminescence patterns is used as one of the must promising methods to determine the state of the local interstellar medium (LISM). However, these methods lead to discrepant results that would be hard to understand in the framework of any physical LISM scenario. Assuming that the observational data are reliable, two possibilities which could help to resolve these discrepancies are discussed: (1) the current modeling of resonance luminescence patterns is unsatisfactory and has to be improved, and (2) the extrapolated interstellar parameters are not indicative of the unperturbed LISM state, but rather designate an intermediate state attained in the outer regions of the solar system. It is shown that a quantitative treatment of the neutral gas-plasma interaction effects in the interface between the heliospheric and the interstellar plasmas is of major importance for the correct understanding of the whole complex.
Multiphase flow calculation software
Fincke, James R.
2003-04-15
Multiphase flow calculation software and computer-readable media carrying computer executable instructions for calculating liquid and gas phase mass flow rates of high void fraction multiphase flows. The multiphase flow calculation software employs various given, or experimentally determined, parameters in conjunction with a plurality of pressure differentials of a multiphase flow, preferably supplied by a differential pressure flowmeter or the like, to determine liquid and gas phase mass flow rates of the high void fraction multiphase flows. Embodiments of the multiphase flow calculation software are suitable for use in a variety of applications, including real-time management and control of an object system.
Waste Package Lifting Calculation
H. Marr
2000-05-11
The objective of this calculation is to evaluate the structural response of the waste package during the horizontal and vertical lifting operations in order to support the waste package lifting feature design. The scope of this calculation includes the evaluation of the 21 PWR UCF (pressurized water reactor uncanistered fuel) waste package, naval waste package, 5 DHLW/DOE SNF (defense high-level waste/Department of Energy spent nuclear fuel)--short waste package, and 44 BWR (boiling water reactor) UCF waste package. Procedure AP-3.12Q, Revision 0, ICN 0, calculations, is used to develop and document this calculation.
NASA Astrophysics Data System (ADS)
Di Labbio, G.; Kiyanda, C. B.; Mi, X.; Higgins, A. J.; Nikiforakis, N.; Ng, H. D.
2016-06-01
In this study, the applicability of the Chapman-Jouguet (CJ) criterion is tested numerically for heterogeneous explosive media using a simple detonation analog. The analog system consists of a reactive Burgers' equation coupled with an Arrhenius type reaction wave, and the heterogeneity of the explosive media is mimicked using a discrete energy source approach. The governing equation is solved using a second order, finite-volume approach and the average propagation velocity of the discrete detonation is determined by tracking the leading shock front. Consistent with previous studies, the averaged velocity of the leading shock front from the unsteady numerical simulations is also found to be in good agreement with the velocity of a CJ detonation in a uniform medium wherein the energy source is spatially homogenized. These simulations have thus implications for whether the CJ criterion is valid to predict the detonation velocity in heterogeneous explosive media.
Effects of capillary heterogeneity on vapor-liquid counterflow in porous media
Stubos, A.K.; Satik, C.; Yortsos, Y.C.
1992-06-01
Based on a continuum description, the effect of capillary heterogeneity, induced by variation in permeability, on the steady state, countercurrent, vapor-liquid flow in porous media is analyzed. It is shown that the heterogeneity acts as a body force, that may enhance or diminish gravity effects on heat pipes. Selection rules that determine the steady states reached in homogeneous, gravity-driven heat pipes are also formulated. It is shown that the ``infinite`` two-phase zone may terminate by a substantial change in the permeability somewhere in the medium. The two possible sequences, liquid - liquid dominated - dry, or liquid - vapor dominated - dry find applications in geothermal systems. Finally, it is shown that although weak heterogeneity affects only gravity controlled flows, stronger variations in permeability can give rise to significant capillary effects.
Medium-Based Design: Extending a Medium to Create an Exploratory Learning Environment
ERIC Educational Resources Information Center
Rick, Jochen; Lamberty, K. K.
2005-01-01
This article introduces "medium-based" design -- an approach to creating "exploratory learning environments" using the method of "extending a medium". First, the characteristics of exploratory learning environments and medium-based design are described and grounded in related work. Particular attention is given to "extending a medium" --…
A discrete model for compressible flows in heterogeneous media
Le Metayer, O.; Massol, A.; Hank, S.
2011-04-01
This work deals with the building of a discrete model able to describe and to predict the evolution of complex gas flows in heterogeneous media. In many physical applications, large scales numerical simulation is no longer possible because of a lack of computing resources. Indeed the medium topology may be complex due to the presence of many obstacles (walls, pipes, equipments, geometric singularities etc.). Aircraft powerplant compartments are examples where topology is complex due to the presence of pipes, ducts, coolers and other equipment. Other important examples are gas explosions and large scale dispersion of hazardous materials in urban places, cities or underground involving obstacles such as buildings and various infrastructures. In all cases efficient safety responses are required. Then a new discrete model is built and solved in reasonable execution times for large cells volumes including such obstacles. Quantitative comparisons between experimental and numerical results are shown for different significant test cases, showing excellent agreement.
Time-dependent ion transport in heterogeneous permselective systems
NASA Astrophysics Data System (ADS)
Green, Yoav; Yossifon, Gilad
2015-06-01
The current study extends previous analytical and numerical solutions of chronopotentiometric response of one-dimensional systems consisting of three layers to the more realistic two-dimensional (2D) heterogeneous ion-permselective medium. An analytical solution for the transient concentration-polarization problem, under the local electroneutrality approximation and assumption of ideal permselectivity, was obtained using the Laplace transform and separation of variables technique. Then the 2D electric potential was obtained numerically and was compared to the full Poisson-Nernst-Planck solution. It was then shown that the resultant voltage drop across the system varies between the initial Ohmic response and that of the steady state accounting for concentration polarization. Also, the field-focusing effect in a 2D system is shown to result in a faster depletion of ions at the permselective interface.
Time-dependent ion transport in heterogeneous permselective systems.
Green, Yoav; Yossifon, Gilad
2015-06-01
The current study extends previous analytical and numerical solutions of chronopotentiometric response of one-dimensional systems consisting of three layers to the more realistic two-dimensional (2D) heterogeneous ion-permselective medium. An analytical solution for the transient concentration-polarization problem, under the local electroneutrality approximation and assumption of ideal permselectivity, was obtained using the Laplace transform and separation of variables technique. Then the 2D electric potential was obtained numerically and was compared to the full Poisson-Nernst-Planck solution. It was then shown that the resultant voltage drop across the system varies between the initial Ohmic response and that of the steady state accounting for concentration polarization. Also, the field-focusing effect in a 2D system is shown to result in a faster depletion of ions at the permselective interface.
Monte Carlo Code System for Electron (Positron) Dose Kernel Calculations.
1999-05-12
Version 00 KERNEL performs dose kernel calculations for an electron (positron) isotropic point source in an infinite homogeneous medium. First, the auxiliary code PRELIM is used to prepare cross section data for the considered medium. Then the KERNEL code simulates the transport of electrons and bremsstrahlung photons through the medium until all particles reach their cutoff energies. The deposited energy is scored in concentric spherical shells at a radial distance ranging from zero to twicemore » the source particle range.« less
Neutrino oscillations in low density medium.
Ioannisian, A N; Smirnov, A Y
2004-12-10
We have solved the evolution equation for neutrinos in a low density medium, V
Calculators and Polynomial Evaluation.
ERIC Educational Resources Information Center
Weaver, J. F.
The intent of this paper is to suggest and illustrate how electronic hand-held calculators, especially non-programmable ones with limited data-storage capacity, can be used to advantage by students in one particular aspect of work with polynomial functions. The basic mathematical background upon which calculator application is built is summarized.…
ERIC Educational Resources Information Center
Phillips-Bey, Carol K.
2004-01-01
This article describes TI-73 calculator activities appropriate for middle school students. It was found that the use of the calculator allowed for higher-level thinking and a richer exploration of mathematical ideas by students. [Included with this article are "Dice Roll Worksheet" and "Transforming Tree Worksheet".] (Contains 9 figures.)
Heterogeneous Factor Analysis Models: A Bayesian Approach.
ERIC Educational Resources Information Center
Ansari, Asim; Jedidi, Kamel; Dube, Laurette
2002-01-01
Developed Markov Chain Monte Carlo procedures to perform Bayesian inference, model checking, and model comparison in heterogeneous factor analysis. Tested the approach with synthetic data and data from a consumption emotion study involving 54 consumers. Results show that traditional psychometric methods cannot fully capture the heterogeneity in…
Understanding the Executive Functioning Heterogeneity in Schizophrenia
ERIC Educational Resources Information Center
Raffard, Stephane; Bayard, Sophie
2012-01-01
Schizophrenia is characterized by heterogeneous brain abnormalities involving cerebral regions implied in the executive functioning. The dysexecutive syndrome is one of the most prominent and functionally cognitive features of schizophrenia. Nevertheless, it is not clear to what extend executive deficits are heterogeneous in schizophrenia…
Improving tumour heterogeneity MRI assessment with histograms
Just, N
2014-01-01
By definition, tumours are heterogeneous. They are defined by marked differences in cells, microenvironmental factors (oxygenation levels, pH, VEGF, VPF and TGF-α) metabolism, vasculature, structure and function that in turn translate into heterogeneous drug delivery and therapeutic outcome. Ways to estimate quantitatively tumour heterogeneity can improve drug discovery, treatment planning and therapeutic responses. It is therefore of paramount importance to have reliable and reproducible biomarkers of cancerous lesions' heterogeneity. During the past decade, the number of studies using histogram approaches increased drastically with various magnetic resonance imaging (MRI) techniques (DCE-MRI, DWI, SWI etc.) although information on tumour heterogeneity remains poorly exploited. This fact can be attributed to a poor knowledge of the available metrics and of their specific meaning as well as to the lack of literature references to standardised histogram methods with which surrogate markers of heterogeneity can be compared. This review highlights the current knowledge and critical advances needed to investigate and quantify tumour heterogeneity. The key role of imaging techniques and in particular the key role of MRI for an accurate investigation of tumour heterogeneity is reviewed with a particular emphasis on histogram approaches and derived methods. PMID:25268373
Characterizing heterogeneous cellular responses to perturbations.
Slack, Michael D; Martinez, Elisabeth D; Wu, Lani F; Altschuler, Steven J
2008-12-01
Cellular populations have been widely observed to respond heterogeneously to perturbation. However, interpreting the observed heterogeneity is an extremely challenging problem because of the complexity of possible cellular phenotypes, the large dimension of potential perturbations, and the lack of methods for separating meaningful biological information from noise. Here, we develop an image-based approach to characterize cellular phenotypes based on patterns of signaling marker colocalization. Heterogeneous cellular populations are characterized as mixtures of phenotypically distinct subpopulations, and responses to perturbations are summarized succinctly as probabilistic redistributions of these mixtures. We apply our method to characterize the heterogeneous responses of cancer cells to a panel of drugs. We find that cells treated with drugs of (dis-)similar mechanism exhibit (dis-)similar patterns of heterogeneity. Despite the observed phenotypic diversity of cells observed within our data, low-complexity models of heterogeneity were sufficient to distinguish most classes of drug mechanism. Our approach offers a computational framework for assessing the complexity of cellular heterogeneity, investigating the degree to which perturbations induce redistributions of a limited, but nontrivial, repertoire of underlying states and revealing functional significance contained within distinct patterns of heterogeneous responses.
Heterogeneity in Health Care Computing Environments
Sengupta, Soumitra
1989-01-01
This paper discusses issues of heterogeneity in computer systems, networks, databases, and presentation techniques, and the problems it creates in developing integrated medical information systems. The need for institutional, comprehensive goals are emphasized. Using the Columbia-Presbyterian Medical Center's computing environment as the case study, various steps to solve the heterogeneity problem are presented.
Functional Heterogeneity and Senior Management Team Effectiveness
ERIC Educational Resources Information Center
Benoliel, Pascale; Somech, Anit
2016-01-01
Purpose: There has been an increasing trend toward the creation of senior management teams (SMTs) which are characterized by a high degree of functional heterogeneity. Although such teams may create better linkages to information, along with the benefits of functional heterogeneity comes the potential for conflicts that stem from the value…
Variance of phase fluctuations of waves propagating through a random medium
NASA Technical Reports Server (NTRS)
Chu, Nelson C.; Kong, Jin AU; Yueh, Simon H.; Nghiem, Son V.; Fleischman, Jack G.; Ayasli, Serpil; Shin, Robert T.
1992-01-01
As an electromagnetic wave propagates through a random scattering medium, such as a forest, its energy is attenuated and random phase fluctuations are induced. The magnitude of the random phase fluctuations induced is important in estimating how well a Synthetic Aperture Radar (SAR) can image objects within the scattering medium. The two-layer random medium model, consisting of a scattering layer between free space and ground, is used to calculate the variance of the phase fluctuations induced between a transmitter located above the random medium and a receiver located below the random medium. The scattering properties of the random medium are characterized by a correlation function of the random permittivity fluctuations. The effective permittivity of the random medium is first calculated using the strong fluctuation theory, which accounts for large permittivity fluctuations of the scatterers. The distorted Born approximation is used to calculate the first-order scattered field. A perturbation series for the phase of the received field in the Rytov approximation is then introduced and the variance of the phase fluctuations is also calculated assuming that the transmitter and receiver are in the paraxial limit of the random medium, which allows an analytic solution to be obtained. Results are compared using the paraxial approximation, scalar Green's function formulation, and dyadic Green's function formulation. The effects studied are the dependence of the variance of the phase fluctuations on receiver location in lossy and lossless regions, medium thickness, correlation length and fractional volume of scatterers, depolarization of the incident wave, ground layer permittivity, angle of incidence, and polarization.
Relativistic shell model calculations
NASA Astrophysics Data System (ADS)
Furnstahl, R. J.
1986-06-01
Shell model calculations are discussed in the context of a relativistic model of nuclear structure based on renormalizable quantum field theories of mesons and baryons (quantum hadrodynamics). The relativistic Hartree approximation to the full field theory, with parameters determined from bulk properties of nuclear matter, predicts a shell structure in finite nuclei. Particle-hole excitations in finite nuclei are described in an RPA calculation based on this QHD ground state. The particle-hole interaction is prescribed by the Hartree ground state, with no additional parameters. Meson retardation is neglected in deriving the RPA equations, but it is found to have negligible effects on low-lying states. The full Dirac matrix structure is maintained throughout the calculation; no nonrelativistic reductions are made. Despite sensitive cancellations in the ground state calculation, reasonable excitation spectra are obtained for light nuclei. The effects of including charged mesons, problems with heavy nuclei, and prospects for improved and extended calculations are discussed.
The constant displacement scheme for tracking particles in heterogeneous aquifers
Wen, X.H.; Gomez-Hernandez, J.J.
1996-01-01
Simulation of mass transport by particle tracking or random walk in highly heterogeneous media may be inefficient from a computational point of view if the traditional constant time step scheme is used. A new scheme which adjusts automatically the time step for each particle according to the local pore velocity, so that each particle always travels a constant distance, is shown to be computationally faster for the same degree of accuracy than the constant time step method. Using the constant displacement scheme, transport calculations in a 2-D aquifer model, with nature log-transmissivity variance of 4, can be 8.6 times faster than using the constant time step scheme.
The Three-Dimensional Combustion of Heterogeneous Propellants
NASA Technical Reports Server (NTRS)
Massa, L.; Jackson, T. L.; Buckmaster, J.; Campbell, M.
2002-01-01
A numerical framework is described which permits the calculation of the 3-D combustion field supported by a heterogeneous propellant, allowing for complete coupling between the condensed phase physics, the gas-phase physics, and the unsteady, uneven, regressing surface. A random packing algorithm is used to construct models of ammonium-perchlorate in hydroxyl-terminated-polybutadiene propellants which mimic experimental propellants designed by R. Miller, and these are numerically burnt. Mean burning rates are compared with experimental data for four packs, over a pressure range of 7-200atm.
WE-E-17A-06: Assessing the Scale of Tumor Heterogeneity by Complete Hierarchical Segmentation On MRI
Gensheimer, M; Trister, A; Ermoian, R; Hawkins, D
2014-06-15
Purpose: In many cancers, intratumoral heterogeneity exists in vascular and genetic structure. We developed an algorithm which uses clinical imaging to interrogate different scales of heterogeneity. We hypothesize that heterogeneity of perfusion at large distance scales may correlate with propensity for disease recurrence. We applied the algorithm to initial diagnosis MRI of rhabdomyosarcoma patients to predict recurrence. Methods: The Spatial Heterogeneity Analysis by Recursive Partitioning (SHARP) algorithm recursively segments the tumor image. The tumor is repeatedly subdivided, with each dividing line chosen to maximize signal intensity difference between the two subregions. This process continues to the voxel level, producing segments at multiple scales. Heterogeneity is measured by comparing signal intensity histograms between each segmented region and the adjacent region. We measured the scales of contrast enhancement heterogeneity of the primary tumor in 18 rhabdomyosarcoma patients. Using Cox proportional hazards regression, we explored the influence of heterogeneity parameters on relapse-free survival (RFS). To compare with existing methods, fractal and Haralick texture features were also calculated. Results: The complete segmentation produced by SHARP allows extraction of diverse features, including the amount of heterogeneity at various distance scales, the area of the tumor with the most heterogeneity at each scale, and for a given point in the tumor, the heterogeneity at different scales. 10/18 rhabdomyosarcoma patients suffered disease recurrence. On contrast-enhanced MRI, larger scale of maximum signal intensity heterogeneity, relative to tumor diameter, predicted for shorter RFS (p=0.05). Fractal dimension, fractal fit, and three Haralick features did not predict RFS (p=0.09-0.90). Conclusion: SHARP produces an automatic segmentation of tumor regions and reports the amount of heterogeneity at various distance scales. In rhabdomyosarcoma, RFS was
NASA Astrophysics Data System (ADS)
Santoro, Ylenia; Leproux, Anaïs; Cerussi, Albert; Tromberg, Bruce; Gratton, Enrico
2011-09-01
We describe an algorithm to calculate an index that characterizes spatial differences in broadband near-infrared [(NIR), 650-1000 nm] absorption spectra of tumor-containing breast tissue. Patient-specific tumor spatial heterogeneities are visualized through a heterogeneity spectrum function (HS). HS is a biomarker that can be attributed to different molecular distributions within the tumor. To classify lesion heterogeneities, we built a heterogeneity index (HI) derived from the HS by weighing the HS in specific NIR absorption bands. It is shown that neoadjuvant chemotherapy (NAC) response is potentially related to the tumor heterogeneity. Therefore, we correlate the heterogeneity index obtained prior to treatment with the final response to NAC. From a pilot study of 15 cancer patients treated with NAC, pathological complete responders (pCR) were separated from non-pCR according to their HI (-44 +/- 12 and 43 +/- 17, p = 3 × 10-8, respectively). We conclude that the HS function is a biomarker that can be used to visualize spatial heterogeneities in lesions, and the baseline HI prior to therapy correlates with chemotherapy pathological response.
NASA Astrophysics Data System (ADS)
Leidi, Tiziano; Scocchi, Giulio; Grossi, Loris; Pusterla, Simone; D'Angelo, Claudio; Thiran, Jean-Philippe; Ortona, Alberto
2012-11-01
In recent decades, finite element (FE) techniques have been extensively used for predicting effective properties of random heterogeneous materials. In the case of very complex microstructures, the choice of numerical methods for the solution of this problem can offer some advantages over classical analytical approaches, and it allows the use of digital images obtained from real material samples (e.g., using computed tomography). On the other hand, having a large number of elements is often necessary for properly describing complex microstructures, ultimately leading to extremely time-consuming computations and high memory requirements. With the final objective of reducing these limitations, we improved an existing freely available FE code for the computation of effective conductivity (electrical and thermal) of microstructure digital models. To allow execution on hardware combining multi-core CPUs and a GPU, we first translated the original algorithm from Fortran to C, and we subdivided it into software components. Then, we enhanced the C version of the algorithm for parallel processing with heterogeneous processors. With the goal of maximizing the obtained performances and limiting resource consumption, we utilized a software architecture based on stream processing, event-driven scheduling, and dynamic load balancing. The parallel processing version of the algorithm has been validated using a simple microstructure consisting of a single sphere located at the centre of a cubic box, yielding consistent results. Finally, the code was used for the calculation of the effective thermal conductivity of a digital model of a real sample (a ceramic foam obtained using X-ray computed tomography). On a computer equipped with dual hexa-core Intel Xeon X5670 processors and an NVIDIA Tesla C2050, the parallel application version features near to linear speed-up progression when using only the CPU cores. It executes more than 20 times faster when additionally using the GPU.
Annous, B A; Kozempel, M F
1998-05-01
Pediococcus sp. is a nonpathogenic heat-resistant spoilage organism that has been used as a test organism in milk pasteurization studies. These characteristics make this bacterium an attractive test organism to study the mode of bacterial thermal inactivation in a food pilot plant. We report here the effect of growth medium on the thermal D value of this organism in skim milk, whole liquid egg, 10% glucose solution, pineapple juice, apple juice, tomato juice, and water at 60 degrees C. Thermal inactivation was done in a submerged coil; D values were calculated from the linear portion of the survival curves by linear regression analysis. The range of D values of stationary-phase cells grown at 28 degrees C in tryptone glucose yeast extract (TGY) or tryptic soy broth (TSB) was 0.14 to 12.05 min in all heating menstrua tested. The TSB-grown cells exhibited the highest thermal resistance with skim milk and 10% glucose solution as the heating menstrua. Survival curves of the TGY-grown cells indicated the presence of a cell population heterogeneous in thermal resistance. The TSB-grown cells exhibited a cell population uniform in thermal resistance and with a lag time for thermal inactivation. When compared to TGY-grown cells, Pediococcus sp. grown in TSB showed a significant (P < 0.05) increase in D values by up to eightfold in all heating menstrua. Results from this study suggested that thermal inactivation of Pediococcus sp. was dependent on the growth medium and on the heating menstruum with respect to both pH and composition.
Spin crossover in ferropericlase and velocity heterogeneities in the lower mantle.
Wu, Zhongqing; Wentzcovitch, Renata M
2014-07-22
Deciphering the origin of seismic velocity heterogeneities in the mantle is crucial to understanding internal structures and processes at work in the Earth. The spin crossover in iron in ferropericlase (Fp), the second most abundant phase in the lower mantle, introduces unfamiliar effects on seismic velocities. First-principles calculations indicate that anticorrelation between shear velocity (VS) and bulk sound velocity (Vφ) in the mantle, usually interpreted as compositional heterogeneity, can also be produced in homogeneous aggregates containing Fp. The spin crossover also suppresses thermally induced heterogeneity in longitudinal velocity (VP) at certain depths but not in VS. This effect is observed in tomography models at conditions where the spin crossover in Fp is expected in the lower mantle. In addition, the one-of-a-kind signature of this spin crossover in the RS/P (∂ ln VS/∂ ln VP) heterogeneity ratio might be a useful fingerprint to detect the presence of Fp in the lower mantle. PMID:25002507
Anatomical heterogeneity of Alzheimer disease
Noh, Young; Jeon, Seun; Seo, Sang Won; Kim, Geon Ha; Cho, Hanna; Ye, Byoung Seok; Yoon, Cindy W.; Kim, Hee Jin; Chin, Juhee; Park, Kee Hyung; Heilman, Kenneth M.
2014-01-01
Objective: Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, the goal of this study was to use 3-dimensional MRI to examine the various patterns of cortical atrophy that can be associated with dementia of AD type, and to investigate whether AD dementia can be categorized into anatomical subtypes. Methods: High-resolution T1-weighted volumetric MRIs were taken of 152 patients in their earlier stages of AD dementia. The images were processed to measure cortical thickness, and hierarchical agglomerative cluster analysis was performed using Ward's clustering linkage. The identified clusters of patients were compared with an age- and sex-matched control group using a general linear model. Results: There were several distinct patterns of cortical atrophy and the number of patterns varied according to the level of cluster analyses. At the 3-cluster level, patients were divided into (1) bilateral medial temporal–dominant atrophy subtype (n = 52, ∼34.2%), (2) parietal-dominant subtype (n = 28, ∼18.4%) in which the bilateral parietal lobes, the precuneus, along with bilateral dorsolateral frontal lobes, were atrophic, and (3) diffuse atrophy subtype (n = 72, ∼47.4%) in which nearly all association cortices revealed atrophy. These 3 subtypes also differed in their demographic and clinical features. Conclusions: This cluster analysis of cortical thickness of the entire brain showed that AD dementia in the earlier stages can be categorized into various anatomical subtypes, with distinct clinical features. PMID:25344382
NMR Measures of Heterogeneity Length
NASA Astrophysics Data System (ADS)
Spiess, Hans W.
2002-03-01
Advanced solid state NMR spectroscopy provides a wealth of information about structure and dynamics of complex systems. On a local scale, multidimensional solid state NMR has elucidated the geometry and the time scale of segmental motions at the glass transition. The higher order correlation functions which are provided by this technique led to the notion of dynamic heterogeneities, which have been characterized in detail with respect to their rate memory and length scale. In polymeric and low molar mass glass formers of different fragility, length scales in the range 2 to 4 nm are observed. In polymeric systems, incompatibility of backbone and side groups as in polyalkylmethacrylates leads to heteogeneities on the nm scale, which manifest themselves in unusual chain dynamics at the glass transition involving extended chain conformations. References: K. Schmidt-Rohr and H.W. Spiess, Multidimensional Solid-State NMR and Polymers,Academic Press, London (1994). U. Tracht, M. Wilhelm, A. Heuer, H. Feng, K. Schmidt-Rohr, H.W. Spiess, Phys. Rev. Lett. 81, 2727 (1998). S.A. Reinsberg, X.H. Qiu, M. Wilhelm, M.D. Ediger, H.W. Spiess, J.Chem.Phys. 114, 7299 (2001). S.A. Reinsberg, A. Heuer, B. Doliwa, H. Zimmermann, H.W. Spiess, J. Non-Crystal. Solids, in press (2002)
Genetic heterogeneity in osteogenesis imperfecta.
Sillence, D O; Senn, A; Danks, D M
1979-01-01
An epidemiological and genetical study of osteogenesis imperfecta (OI) in Victoria, Australia confirmed that there are at least four distinct syndromes at present called OI. The largest group of patients showed autosomal dominant inheritance of osteoporosis leading to fractures and distinctly blue sclerae. A large proportion of adults had presenile deafness or a family history of presenile conductive hearing loss. A second group, who comprised the majority of newborns with neonatal fractures, all died before or soon after birth. These had characteristic broad, crumpled femora and beaded ribs in skeletal x-rays. Autosomal recessive inheritance was likely for some, if not all, of these cases. A third group, two thirds of whom had fractures at birth, showed severe progressive deformity of limbs and spine. The density of scleral blueness appeared less than that seen in the first group of patients and approximated that seen in normal children and adults. Moreover, the blueness appeared to decrease with age. All patients in this group were sporadic cases. The mode of inheritance was not resolved by the study, but it is likely that the group is heterogeneous with both dominant and recessive genotypes responsible for the syndrome. The fourth group of patients showed dominant inheritance of osteoporosis leading to fractures, with variable deformity of long bones, but normal sclerae. Images PMID:458828
Distributional Scaling in Heterogeneous Aquifers
NASA Astrophysics Data System (ADS)
Polsinelli, J. F.
2015-12-01
An investigation is undertaken into the fractal scaling properties of the piezometric head in a heterogeneous unconfined aquifer. The governing equations for the unconfined flow are derived from conservation of mass and the Darcy law. The Dupuit approximation will be used to model the dynamics. The spatially varying nature of the tendency to conduct flow (e.g. the hydraulic conductivity) is represented as a stochastic process. Experimental studies in the literature have indicated that the conductivity belongs to a class of non-stationary stochastic fields, called H-ss fields. The uncertainty in the soil parameters is imparted onto the flow variables; in groundwater investigations the potentiometric head will be a random function. The structure of the head field will be analyzed with an emphasis on the scaling properties. The scaling scheme for the modeling equations and the simulation procedure for the saturated hydraulic conductivity process will be explained, then the method will be validated through numerical experimentation using the USGS Modflow-2005 software. The results of the numerical simulations demonstrate that the head will exhibit multi-fractal scaling if the hydraulic conductivity exhibits multi-fractal scaling and the differential equations for the groundwater equation satisfy a particular set of scale invariance conditions.
Bedload sheets in heterogeneous sediment
Whiting, P.J.; Dietrich, W.E.; Leopold, L.B.; Drake, T.G.; Shreve, R.L.
1988-02-01
Field observations in streams with beds of coarse sand and fine gravel have revealed that bedload moves primarily as thin, migrating accumulations of sediment, and coarse grains cluster at their leading edge. These accumulations are one or two coarse grains high and are much longer (0.2-0.6 m long in sand; 0.5-2.0 m in fine gravel) than their height. The authors propose the term bedload sheet for these features, and the authors argue that they result from an instability inherent to bedload movement of moderately and poorly sorted sediment. In essence, coarse particles in the bedload slow or stop each other, trap finer particles in their interstices, and thus cause the coarse particles to become mobile again. Bedload sheets develop on the stoss side of dunes, causing the dune to advance incrementally with the arrival of each sheet. Successive deposition of coarse sediment from the leading edge followed by fine sediment may generate the grain-size sorting that distinguishes cross-bedding. Available flume experiments and field observations indicate that bedload sheets are a common, but generally unrecognized, feature of heterogeneous sediment transport.
Collective foraging in heterogeneous landscapes
Bhattacharya, Kunal; Vicsek, Tamás
2014-01-01
Animals foraging alone are hypothesized to optimize the encounter rates with resources through Lévy walks. However, the issue of how the interactions between multiple foragers influence their search efficiency is still not completely understood. To address this, we consider a model to study the optimal strategy for a group of foragers searching for targets distributed heterogeneously. In our model, foragers move on a square lattice containing immobile but regenerative targets. At any instant, a forager is able to detect only those targets that happen to be in the same site. However, we allow the foragers to have information about the state of other foragers. A forager who has not detected any target walks towards the nearest location, where another forager has detected a target, with a probability exp(−αd), where d is the distance between the foragers and α is a parameter characterizing the propensity of the foragers to aggregate. The model reveals that neither overcrowding (α → 0) nor independent searching (α → ∞) is beneficial for the foragers. For a patchy distribution of targets, the efficiency is maximum for intermediate values of α. In addition, in the limit α → 0, the length of the walks can become scale-free. PMID:25165596
Aggregation of Heterogeneously Charged Colloids.
Dempster, Joshua M; Olvera de la Cruz, Monica
2016-06-28
Patchy colloids are attractive as programmable building blocks for metamaterials. Inverse patchy colloids, in which a charged surface is decorated with patches of the opposite charge, are additionally noteworthy as models for heterogeneously charged biological materials such as proteins. We study the phases and aggregation behavior of a single charged patch in an oppositely charged colloid with a single-site model. This single-patch inverse patchy colloid model shows a large number of phases when varying patch size. For large patch sizes we find ferroelectric crystals, while small patch sizes produce cross-linked gels. Intermediate values produce monodisperse clusters and unusual worm structures that preserve finite ratios of area to volume. The polarization observed at large patch sizes is robust under extreme disorder in patch size and shape. We examine phase-temperature dependence and coexistence curves and find that large patch sizes produce polarized liquids, in contrast to mean-field predictions. Finally, we introduce small numbers of unpatched charged colloids. These can either suppress or encourage aggregation depending on their concentration and the size of the patches on the patched colloids. These effects can be exploited to control aggregation and to measure effective patch size.
The Heterogeneity of Juvenile Myositis
Rider, Lisa G.
2007-01-01
Juvenile myositis is a heterogeneous group of systemic autoimmune diseases, in which clinical and serologic subgroups result in subsets of patients with distinct clinical manifestations, disease courses, immunogenetic associations, responses to therapy, and prognoses. A newly identified autoantibody of unknown specificity, anti-p155, is myositis-associated and seen in up to 20 – 30% of juvenile and adult DM patients. HLA DRB1*0301 and its linked allele DQA1*0501 have been identified as the major immunogenetic risk factor for juvenile and adult DM in both European- and African- American patients, and DQA1*0301 is an additional risk factor in European American patients. Several DQA1 alleles also are protective for juvenile DM. Environmental risk factors are poorly understood, but growing evidence suggests a role for infectious agents and ultraviolet radiation. The current therapy of juvenile DM consists of corticosteroids and other immunosuppressive agents, with the adjunctive treatment of cutaneous manifestations and rehabilitation. Therapeutic trials of biologic agents, including anti-TNFα and anti-CD20, may aid in developing promising new therapies for these disorders. PMID:17317616
Genetic heterogeneity in juvenile NCL
Hart, Y.M.; Andermann, E.; Mitchison, H.M.
1994-09-01
The neuronal ceroid lipofuscinoses (NCL) are a group of related lysosomal storage diseases classified according to the age of onset, clinical syndrome, and pathology. The clinical syndromes include myoclonus, visual failure, progressive dementia, ataxia and generalized tonic clonic seizures in varying combinations depending on the age of onset and pathology. The mode of inheritance is autosomal recessive in most cases, except for several families with the adult form (Kufs` disease) which have autosomal dominant inheritance. Linkage for the infantile (Halatia-Santavuori) form (CLN1), characterized ultrastructurally by lysosomal granular osmiophilic deposits (GROD), has been demonstrated with markers on chromosome lp, while the gene for the typical juvenile (Spielmeyer-Vogt) form (CLN3), characterized by fingerprint-profile inclusions, has been linked to chromosome 16p. The gene locations of the late infantile (Jansky-Bielschowsky) and adult (Kufs` disease) forms are unknown, although it has recently been shown that the late infantile form does not link to chromosome 16p. We describe three siblings, including a pair of monozygotic twins, with juvenile onset NCL with GROD in whom linkage to the CLN3 region of chromsome 16p has been excluded. This would suggest that there is genetic heterogeneity not only among the different clinical syndromes, but also among identical clinical syndromes with different ultrastructural characteristics. Preliminary studies of linkage to chromosome 1p employing the microsatellite marker HY-TM1 have been uninformative. Further studies with other chromosome 1 markers are underway.
Quantification of heterogeneity observed in medical images
2013-01-01
Background There has been much recent interest in the quantification of visually evident heterogeneity within functional grayscale medical images, such as those obtained via magnetic resonance or positron emission tomography. In the case of images of cancerous tumors, variations in grayscale intensity imply variations in crucial tumor biology. Despite these considerable clinical implications, there is as yet no standardized method for measuring the heterogeneity observed via these imaging modalities. Methods In this work, we motivate and derive a statistical measure of image heterogeneity. This statistic measures the distance-dependent average deviation from the smoothest intensity gradation feasible. We show how this statistic may be used to automatically rank images of in vivo human tumors in order of increasing heterogeneity. We test this method against the current practice of ranking images via expert visual inspection. Results We find that this statistic provides a means of heterogeneity quantification beyond that given by other statistics traditionally used for the same purpose. We demonstrate the effect of tumor shape upon our ranking method and find the method applicable to a wide variety of clinically relevant tumor images. We find that the automated heterogeneity rankings agree very closely with those performed visually by experts. Conclusions These results indicate that our automated method may be used reliably to rank, in order of increasing heterogeneity, tumor images whether or not object shape is considered to contribute to that heterogeneity. Automated heterogeneity ranking yields objective results which are more consistent than visual rankings. Reducing variability in image interpretation will enable more researchers to better study potential clinical implications of observed tumor heterogeneity. PMID:23453000
Estimation of Porous Medium Tortuosity Directly from Flow Path Lines
NASA Astrophysics Data System (ADS)
Pakalapati, Suryanarayana; Celik, Ismail
2013-11-01
A thorough understanding of transport processes inside porous materials is vital for improving the efficiency of energy devices such as fuel cells and batteries. Continuum simulations of porous media make use of parameters such as porosity and tortuosity to account for the influence of the actual pore geometry and orientation on the transport processes. In most studies the tortuosity is treated as an adjustable parameter which is calibrated to match the predictions with the experiments. In this study a direct method is utilized to estimate the tortuosity of a porous medium. The actual geometry of a fuel cell electrode is obtained from an experimental study where the porous structure is reconstructed from slice images. The detailed geometry of porous medium is used to simulate fully resolved fluid flow through the pores. Stream lines are then generated which show the actual paths taken by the fluid flowing through the porous medium. The lengths of these path lines are then used to calculate the tortuosity of the porous medium by employing the actual definition of the tortuosity. It is shown that the tortuosities obtained in this way are smaller than the typical values reported in literature.
Modeling variations of medium porosity in rotating drum biofilter.
Yang, Chunping; Chen, Hong; Zeng, Guangming; Yu, Guanlong; Liu, Xianfeng; Zhang, Xiaoming
2009-01-01
Rotating drum biofilters (RDBs) mounted with reticulated polyurethane sponge media has showed high removal efficiencies over a long period of time when used for volatile organic compound (VOC) removal. Due to the accumulation of biomass within the sponge medium, the porosity of a filter bed usually changes dynamically, which makes it difficult to predict and to control. In this paper, the porosity of a multi-layer RDB bed was investigated by a diffusion-reaction model in which biofilm growth and decay were taken into account at the pore scale of the sponge medium. Temporal and spatial changes of porosity were studied under various organic loadings and gas empty bed contact times (EBCTs). The porosity of the biofilter bed was assumed to be a function of biofilm thickness, and all the pores were assumed to be uniform. Toluene was selected as the model VOC. The model was solved using numerical methods through the MATLAB software. Results show that the porosity decreased with increased time of operation, increased toluene loading, or decreased gas EBCT value. The porosity in the outermost medium layer was less than that in the inner medium layers. Toluene removal efficiencies and porosities calculated from this model correlated with the experimental data well. Porosity variation was proposed to be an indicator for prediction of biofilter performance in biofilters as a consequence. PMID:18951611
Medium Modification of the Light Vector Mesons in Nuclei
Nasseripour, R.; Djalali, C.; Wood, M.; Weygand, D.
2008-10-13
Theoretical calculations predict the modification of properties of vector mesons, such as a shift in their masses and/or broadening of their widths in dense nuclear matter. These effects can be related to partial restoration of chiral symmetry at high density or temperature. Photoproduction of vector mesons off nuclei were performed at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). The data were taken with a beam of tagged photons with energies up to 4 GeV on various nuclear targets. The properties of the {rho} vector mesons were investigated via their rare leptonic decay to e+e{sup -}. This decay channel is preferred over hadronic modes in order to eliminate final state interactions in the nuclear matter. The combinatorial background in the mass spectrum was removed by a self-normalizing mixed-event technique. The {rho} meson mass distributions were extracted for each of the targets. Statistically significant results regarding medium modification of the rho meson in the nuclear medium rule out large medium effects. Transparency studies of the {omega} and {phi} vector mesons allows a determination of their widths in the medium.
Propagation of a finite optical beam in an inhomogeneous medium.
Lutomirski, R F; Yura, H T
1971-07-01
The first part of this paper is devoted to extending the Huygens-Fresnel principle to a medium that exhibits a spatial (but not temporal) variation in index of refraction. Utilizing a reciprocity theorem for a monochromatic disturbance in a weakly inhomogeneous medium, it is shown that the secondary wave-front will be determined by the envelope of spherical wavelets from the primary wavefront, as in the vacuum problem, but that each wavelet is now determined by the propagation of a spherical wave in the refractive medium. In the second part, the above development is applied to the case in which the index of refraction is a random variable; a further application of the reciprocity theorem results in a formula for the mean intensity distribution from a finite aperture in terms of the complex disturbance in the aperture and the modulation transfer function (MTF) for a spherical wave in the medium. The results are applicable for an arbitrary complex disturbance in the transmitting aperture in both the Fresnel and Fraunhofer regions of the aperture. Using a Kolmogorov spectrum for the index of refraction fluctuations and a second-order expression for the MTF, the formula is used to calculate the mean intensity distribution for a plane wave diffracting from a circular aperture and to give approximate expressions for the beam spreading at various ranges. PMID:20111181
Scale-Dependent Dispersivity Explained Without Scale-Dependent Heterogeneity
NASA Astrophysics Data System (ADS)
Dhaliwal, P.; Engdahl, N. B.; Fogg, G. E.
2011-12-01
The observed scale-dependence of dispersivity has often been attributed to the scale-dependence of porous media heterogeneity. However, mass transfer between areas of high and low hydraulic conductivity and preferential solute migration may provide an alternative explanation for this phenomenon. To illustrate this point, we used geostatistical models representing the heterogeneity and interconnectedness of a typical aquifer system and plume modeling via a highly accurate random walk particle tracking method. The apparent dispersivity values were calculated using the statistical moments of the plumes. Apparent dispersivity was seen to grow from 0.01(m)to 100(m) over length scales of 0.06(m) to 500(m) even though heterogeneity scales and facies proportions were stationary and invariant with scale in the simulations. The results suggest that the increase in dispersivity was due solely to a stretching of the plume by two mechanisms. The first mechanism results from the diffusion of solute into areas of low conductivity and the second comes from the movement of solute through well-connected high K zone channels. Under such conditions, an "asymptotic dispersivity" may never be reached.
Dielectric analysis of heterogeneous biological tissues based on mixing rule.
Zhang, Liang; Liu, Peiguo; Dong, Xiuzhen; Zhou, Dongming; Shi, Xuetao
2015-01-01
Thus far, the measurement of dielectric properties of biological tissues has been achieved on the assumption that the biological tissues are homogeneous. In fact, most tissues should be heterogeneous because there are many small structures included in these tissues, such as blood vessel, nerve fiber and so on. When the dielectric properties of these tissues are measured by conventional sensor, the results are not the dielectric properties of tissues but the effective dielectric properties of the mixture. In this paper, the influence of the inclusion in tissues on the measurement of dielectric properties of heterogeneous biological tissues is studied and the analysis of the effective dielectric properties of heterogeneous tissues based on the mixing rule is proposed. When the coaxial probe is used to measure the dielectric properties of tissue, the results are relative to the dielectric properties of inclusion, dielectric properties of background tissue and the effective volume fraction of inclusion. Therefore, the dielectric properties of inclusion could be calculated according to mixing rule, after the effective dielectric properties are measured and the effective volume fraction of inclusion is estimated.
Dielectric analysis of heterogeneous biological tissues based on mixing rule.
Zhang, Liang; Liu, Peiguo; Dong, Xiuzhen; Zhou, Dongming; Shi, Xuetao
2015-01-01
Thus far, the measurement of dielectric properties of biological tissues has been achieved on the assumption that the biological tissues are homogeneous. In fact, most tissues should be heterogeneous because there are many small structures included in these tissues, such as blood vessel, nerve fiber and so on. When the dielectric properties of these tissues are measured by conventional sensor, the results are not the dielectric properties of tissues but the effective dielectric properties of the mixture. In this paper, the influence of the inclusion in tissues on the measurement of dielectric properties of heterogeneous biological tissues is studied and the analysis of the effective dielectric properties of heterogeneous tissues based on the mixing rule is proposed. When the coaxial probe is used to measure the dielectric properties of tissue, the results are relative to the dielectric properties of inclusion, dielectric properties of background tissue and the effective volume fraction of inclusion. Therefore, the dielectric properties of inclusion could be calculated according to mixing rule, after the effective dielectric properties are measured and the effective volume fraction of inclusion is estimated. PMID:26406034
The Circumgalactic Medium of Quasars
NASA Astrophysics Data System (ADS)
Hennawi, Joe
2014-07-01
I will argue that observations of the diffuse gas in the outskirts of quasar host galaxies, or the so called circumgalactic medium, are essential for understanding how luminous quasars evolve in a cosmological context. Such observations also provide a fruitful comparison to theory, because hydrodynamics at moderate overdensities is much easier to simulate than the complicated processes which trigger quasar activity. A novel technique will be introduced, whereby a foreground quasar can be studied in absorption against a background quasar, resolving scales as small as 30 kpc. This experiment reveals a rich absorption spectrum which contains a wealth of information about the physical conditions of diffuse gas around quasars. Hydrodynamical simulations of the massive dark matter halos which host luminous quasars under predict the amount of cool gas observed in quasar environs by a large factor, challenging our understanding of how massive galaxies form. I will also discuss a very sensitive search for Ly-alpha emission from the same gas which we study in absorption.
Studies in medium energy physics
Green, A.; Hoffmann, G.W.; McDonough, J.; Purcell, M.J.; Ray, R.L.; Read, D.E.; Worn, S.D.
1991-12-01
This document constitutes the (1991--1992) technical progress report and continuation proposal for the ongoing medium energy nuclear physics research program supported by the US Department of Energy through special Research Grant DE-FG05-88ER40444. The experiments discussed are conducted at the Los Alamos National Laboratory's (LANL) Clinton P. Anderson Meson Physics Facility (LAMPF) and the Alternating Gradient Synchrotron (AGS) facility of the Brookhaven National Laboratory (BNL). The overall motivation for the work discussed in this document is driven by three main objectives: (1) provide hadron-nucleon and hadron-nucleus scattering data which serve to facilitate the study of effective two-body interactions, test (and possibly determine) nuclear structure, and help study reaction mechanisms and dynamics; (2) provide unique, first-of-a-kind exploratory'' hadron-nucleus scattering data in the hope that such data will lead to discovery of new phenomena and new physics; and (3) perform precision tests of fundamental interactions, such as rare decay searches, whose observation would imply fundamental new physics.
1997-06-10
VENTSAR XL is an EXCEL Spreadsheet that can be used to calculate downwind doses as a result of a hypothetical atmospheric release. Both building effects and plume rise may be considered. VENTSAR XL will run using any version of Microsoft EXCEL version 4.0 or later. Macros (the programming language of EXCEL) was used to automate the calculations. The user enters a minimal amount of input and the code calculates the resulting concentrations and doses atmore » various downwind distances as specified by the user.« less
Mathematical models of tumor heterogeneity and drug resistance
NASA Astrophysics Data System (ADS)
Greene, James
transition rates as a function of global density. Finally, we extend the model of cell-cycle heterogeneity to include spatial variables. Cells are modeled as soft spheres and exhibit attraction/repulsion/random forces. A fundamental hypothesis is that cell-cycle length increases with local density, thus producing a distribution of observed division lengths. Apoptosis occurs primarily through an extended period of unsuccessful proliferation, and the explicit mechanism of the drug (Paclitaxel) is modeled as an increase in cell-cycle duration. We show that the distribution of cell-cycle lengths is highly time-dependent, with close time-averaged agreement with the distribution used in the previous work. Furthermore, survival curves are calculated and shown to qualitatively agree with experimental data in different densities and geometries, thus relating the cellular microenvironment to drug resistance.
Genetic linkage heterogeneity in the fragile X syndrome.
Brown, W T; Gross, A C; Chan, C B; Jenkins, E C
1985-01-01
Genetic linkage between a factor IX DNA restriction fragment length polymorphism (RFLP) and the fragile X chromosome marker was analyzed in eight fragile X pedigrees and compared to eight previously reported pedigrees. A large pedigree with apparently full penetrance in all male members showed a high frequency of recombination. A lod score of -7.39 at theta = 0 and a maximum score of 0.26 at theta = 0.32 were calculated. A second large pedigree with a nonpenetrant male showed tight linkage with a maximum lod score of 3.13 at theta = 0, a result similar to one large pedigree with a nonpenetrant male previously reported. The differences in lod scores seen in these large pedigrees suggested there was genetic heterogeneity in linkage between families which appeared to relate to the presence of nonpenetrant males. The combined lod score for the three pedigrees with nonpenetrant males was 6.84 at theta = 0. For the 13 other pedigrees without nonpenetrant males the combined lod score was -21.81 at theta = 0, with a peak of 0.98 at theta = 0.28. When lod scores from all 16 families were combined, the value was -15.14 at theta = 0 and the overall maximum was 5.13 at theta = 0.17. To determine whether genetic heterogeneity was present, three statistical tests for heterogeneity were employed. First, a "predivided-sample" test was used. The 16 pedigrees were divided into two classes, NP and P, based upon whether or not any nonpenetrant males were detected in the pedigree. This test gave evidence for significant genetic heterogeneity whether the three large pedigrees with seven or more informative males (P less than 0.005), the eight pedigrees with three informative males (P less than 0.001), or all 16 pedigrees (P less than 0.001) were included in the analysis. Second, Morton's large sample test was employed. Significant heterogeneity was present when the analysis was restricted to the three large pedigrees (P less than 0.025), or to the eight pedigrees with informative males
Additional waves in the graphene layered medium.
Chern, Ruey-Lin; Han, Dezhuan; Zhang, Z Q; Chan, C T
2014-12-29
We investigate the features of additional waves that arise in the graphene layered medium, within the framework of nonlocal effective medium model. The additional wave is manifest on the biquadratic dispersion relation of the medium and represents as a distinctive nonlocal character at long wavelength. In particular, the reflection and transmission coefficients for the nonlocal medium are underdetermined by Maxwell's boundary conditions. An additional boundary condition based on modal expansions is proposed to derive the generalized Fresnel equations, based on which the additional wave in the graphene layered medium is determined. The additional wave tends to be significant near the effective plasma frequency, near which the graphene plasmons are excited inside the medium. PMID:25607138
The geometric mean concept for interpreting the permeability of heterogeneous geomaterials
NASA Astrophysics Data System (ADS)
Selvadurai, Patrick; Selvadurai, Paul
2015-04-01
Naturally occurring geomaterials are heterogeneous and the estimation of the effective permeability characteristics of such geomaterials presents a challenge not only in terms of the experimental procedures that should be used to ensure flow through the porous medium but also in the correct use of the theoretical concepts needed to accurately interpret the data. The general consensus is that the flow path in a test needs to be drastically reduced if steady state tests are considered as a suitable experimental technique. The disadvantage of flow path reduction is that the tested volume may not be altogether representative of the rock, particularly if it displays heterogeneity in the scale of the sample being tested. Also, if the sample is not correctly restrained, the differential pressures needed to initiate steady flow can introduce damage in the sample leading to erroneous estimates of permeability. The alternative approach is to use large enough samples that can capture the spatial heterogeneity but develop testing procedures that can test examine the steady state flow process as a problem in three-dimensional fluid flow that can capture the spatial distribution of permeability. The paper discusses theoretical and computational approaches that have been developed for the estimation of the spatial distribution of permeability in a cuboidal Indiana Limestone sample measuring 450 mm. The "Patch Permeability Test" developed in connection with the research allows the measurements of the surface permeability of the block and through kriging techniques estimate the permeability within the block sample. The research promotes the use of the "Geometric Mean" concept for the description of the effective permeability of the heterogeneous porous medium where the spatial distribution conforms to a lognormal pattern. The effectiveness of the approach is that the techniques can be applied to examine the effective permeability of heterogeneous low permeability materials such as
Cooling rate calculations for silicate glasses.
NASA Astrophysics Data System (ADS)
Birnie, D. P., III; Dyar, M. D.
1986-03-01
Series solution calculations of cooling rates are applied to a variety of samples with different thermal properties, including an analog of an Apollo 15 green glass and a hypothetical silicate melt. Cooling rates for the well-studied green glass and a generalized silicate melt are tabulated for different sample sizes, equilibration temperatures and quench media. Results suggest that cooling rates are heavily dependent on sample size and quench medium and are less dependent on values of physical properties. Thus cooling histories for glasses from planetary surfaces can be estimated on the basis of size distributions alone. In addition, the variation of cooling rate with sample size and quench medium can be used to control quench rate.
The performance of dense medium processes
Horsfall, D.W.
1993-12-31
Dense medium washing in baths and cyclones is widely carried out in South Africa. The paper shows the reason for the preferred use of dense medium processes rather than gravity concentrators such as jigs. The factors leading to efficient separation in baths are listed and an indication given of the extent to which these factors may be controlled and embodied in the deployment of baths and dense medium cyclones in the planning stages of a plant.
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The CIPW Normative Calculation.
ERIC Educational Resources Information Center
Bickel, Charles
1979-01-01
The author has rewritten rules for CIPW norm calculation and has written FORTRAN IV programs to assist the student in this procedure. Includes a set of problems utilizing the CIPW norm to illustrate principles of chemical petrology. (MA)
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PHYSICOCHEMICAL PROPERTY CALCULATIONS
Computer models have been developed to estimate a wide range of physical-chemical properties from molecular structure. The SPARC modeling system approaches calculations as site specific reactions (pKa, hydrolysis, hydration) and `whole molecule' properties (vapor pressure, boilin...
More Experiments and Calculations.
ERIC Educational Resources Information Center
Siddons, J. C.
1984-01-01
Describes two experiments that illustrate basic ideas but would be difficult to carry out. Also presents activities and experiments on rainbow cups, electrical charges, electrophorus calculation, pulse electrometer, a skidding car, and on the Oersted effect. (JN)
NASA Technical Reports Server (NTRS)
Bauschlicher, Charles W.; Arnold, James O. (Technical Monitor)
1997-01-01
The current methods of quantum chemical calculations will be reviewed. The accent will be on the accuracy that can be achieved with these methods. The basis set requirements and computer resources for the various methods will be discussed. The utility of the methods will be illustrated with some examples, which include the calculation of accurate bond energies for SiF$_n$ and SiF$_n^+$ and the modeling of chemical data storage.
Source and replica calculations
Whalen, P.P.
1994-02-01
The starting point of the Hiroshima-Nagasaki Dose Reevaluation Program is the energy and directional distributions of the prompt neutron and gamma-ray radiation emitted from the exploding bombs. A brief introduction to the neutron source calculations is presented. The development of our current understanding of the source problem is outlined. It is recommended that adjoint calculations be used to modify source spectra to resolve the neutron discrepancy problem.
Systematics and limit calculations
Fisher, Wade; /Fermilab
2006-12-01
This note discusses the estimation of systematic uncertainties and their incorporation into upper limit calculations. Two different approaches to reducing systematics and their degrading impact on upper limits are introduced. An improved {chi}{sup 2} function is defined which is useful in comparing Poisson distributed data with models marginalized by systematic uncertainties. Also, a technique using profile likelihoods is introduced which provides a means of constraining the degrading impact of systematic uncertainties on limit calculations.
Frictional Heterogeneities Along Carbonate Faults
NASA Astrophysics Data System (ADS)
Collettini, C.; Carpenter, B. M.; Scuderi, M.; Tesei, T.
2014-12-01
The understanding of fault-slip behaviour in carbonates has an important societal impact as a) a significant number of earthquakes nucleate within or propagate through these rocks, and b) half of the known petroleum reserves occur within carbonate reservoirs, which likely contain faults that experience fluid pressure fluctuations. Field studies on carbonate-bearing faults that are exhumed analogues of currently active structures of the seismogenic crust, show that fault rock types are systematically controlled by the lithology of the faulted protolith: localization associated with cataclasis, thermal decomposition and plastic deformation commonly affect fault rocks in massive limestone, whereas distributed deformation, pressure-solution and frictional sliding along phyllosilicates are observed in marly rocks. In addition, hydraulic fractures, indicating cyclic fluid pressure build-ups during the fault activity, are widespread. Standard double direct friction experiments on fault rocks from massive limestones show high friction, velocity neutral/weakening behaviour and significant re-strengthening during hold periods, on the contrary, phyllosilicate-rich shear zones are characterized by low friction, significant velocity strengthening behavior and no healing. We are currently running friction experiments on large rock samples (20x20 cm) in order to reproduce and characterize the interaction of fault rock frictional heterogeneities observed in the field. In addition we have been performing experiments at near lithostatic fluid pressure in the double direct shear configuration within a pressure vessel to test the Rate and State friction stability under these conditions. Our combination of structural observations and mechanical data have been revealing the processes and structures that are at the base of the broad spectrum of fault slip behaviors recently documented by high-resolution geodetic and seismological data.
Graphene-Si heterogeneous nanotechnology
NASA Astrophysics Data System (ADS)
Akinwande, Deji; Tao, Li
2013-05-01
It is widely envisioned that graphene, an atomic sheet of carbon that has generated very broad interest has the largest prospects for flexible smart systems and for integrated graphene-silicon (G-Si) heterogeneous very large-scale integrated (VLSI) nanoelectronics. In this work, we focus on the latter and elucidate the research progress that has been achieved for integration of graphene with Si-CMOS including: wafer-scale graphene growth by chemical vapor deposition on Cu/SiO2/Si substrates, wafer-scale graphene transfer that afforded the fabrication of over 10,000 devices, wafer-scalable mitigation strategies to restore graphene's device characteristics via fluoropolymer interaction, and demonstrations of graphene integrated with commercial Si- CMOS chips for hybrid nanoelectronics and sensors. Metrology at the wafer-scale has led to the development of custom Raman processing software (GRISP) now available on the nanohub portal. The metrology reveals that graphene grown on 4-in substrates have monolayer quality comparable to exfoliated flakes. At room temperature, the high-performance passivated graphene devices on SiO2/Si can afford average mobilities 3000cm2/V-s and gate modulation that exceeds an order of magnitude. The latest growth research has yielded graphene with high mobilities greater than 10,000cm2/V-s on oxidized silicon. Further progress requires track compatible graphene-Si integration via wafer bonding in order to translate graphene research from basic to applied research in commercial R and D laboratories to ultimately yield a viable nanotechnology.
Interoperability of heterogeneous distributed systems
NASA Astrophysics Data System (ADS)
Zaschke, C.; Essendorfer, B.; Kerth, C.
2016-05-01
To achieve knowledge superiority in today's operations interoperability is the key. Budget restrictions as well as the complexity and multiplicity of threats combined with the fact that not single nations but whole areas are subject to attacks force nations to collaborate and share information as appropriate. Multiple data and information sources produce different kinds of data, real time and non-real time, in different formats that are disseminated to the respective command and control level for further distribution. The data is most of the time highly sensitive and restricted in terms of sharing. The question is how to make this data available to the right people at the right time with the right granularity. The Coalition Shared Data concept aims to provide a solution to these questions. It has been developed within several multinational projects and evolved over time. A continuous improvement process was established and resulted in the adaptation of the architecture as well as the technical solution and the processes it supports. Coming from the idea of making use of existing standards and basing the concept on sharing of data through standardized interfaces and formats and enabling metadata based query the concept merged with a more sophisticated service based approach. The paper addresses concepts for information sharing to facilitate interoperability between heterogeneous distributed systems. It introduces the methods that were used and the challenges that had to be overcome. Furthermore, the paper gives a perspective how the concept could be used in the future and what measures have to be taken to successfully bring it into operations.
Mechanical heterogeneities and lithospheric extension
NASA Astrophysics Data System (ADS)
Duretz, Thibault; Petri, Benoit; Mohn, Geoffroy; Schenker, Filippo L.; Schmalholz, Stefan
2016-04-01
Detailed geological and geophysical studies of passive margins have highlighted the multi-stage and depth-dependent aspect of lithospheric thinning. Lithospheric thinning involves a variety of structures (normal faults, low angle detachments, extensional shear zones, extraction faults) and leads to a complex architecture of passive margins (with e.g. necking zone, mantle exhumation, continental allochthons). The processes controlling the generation and evolution of these structures as well as the impact of pre-rift inheritance are so far incompletely understood. In this study, we investigate the impact of pre-rift inheritance on the development of rifted margins using two-dimensional thermo-mechanical models of lithospheric thinning. To first order, we represent the pre-rift mechanical heterogeneities with lithological layering. The rheologies are kept simple (visco-plastic) and do not involve any strain softening mechanism. Our models show that mechanical layering causes multi-stage and depth-dependent extension. In the initial rifting phase, lithospheric extension is decoupled: as the crust undergoes thinning by brittle (frictional-plastic) faults, the lithospheric mantle accommodates extension by symmetric ductile necking. In a second rifting phase, deformation in the crust and lithospheric mantle is coupled and marks the beginning of an asymmetric extension stage. Low angle extensional shear zones develop across the lithosphere and exhume subcontinental mantle. Furthemore, crustal allochthons and adjacent basins develop coevally. We describe as well the thermal evolution predicted by the numerical models and discuss the first-order implications of our results in the context of the Alpine geological history.
Chemically defined medium and Caenorhabditis elegans
NASA Technical Reports Server (NTRS)
Szewczyk, Nathaniel J.; Kozak, Elena; Conley, Catharine A.
2003-01-01
BACKGROUND: C. elegans has been established as a powerful genetic system. Use of a chemically defined medium (C. elegans Maintenance Medium (CeMM)) now allows standardization and systematic manipulation of the nutrients that animals receive. Liquid cultivation allows automated culturing and experimentation and should be of use in large-scale growth and screening of animals. RESULTS: We find that CeMM is versatile and culturing is simple. CeMM can be used in a solid or liquid state, it can be stored unused for at least a year, unattended actively growing cultures may be maintained longer than with standard techniques, and standard C. elegans protocols work well with animals grown in defined medium. We also find that there are caveats to using defined medium. Animals in defined medium grow more slowly than on standard medium, appear to display adaptation to the defined medium, and display altered growth rates as they change the composition of the defined medium. CONCLUSIONS: As was suggested with the introduction of C. elegans as a potential genetic system, use of defined medium with C. elegans should prove a powerful tool.
NASA Astrophysics Data System (ADS)
Atchley, Adam L.; Navarre-Sitchler, Alexis K.; Maxwell, Reed M.
2014-09-01
The role of coupled physical and geochemical heterogeneities in hydro-geochemical transport is investigated by simulating three-dimensional transport in a heterogeneous system with kinetic mineral reactions. Ensembles of 100 physically heterogeneous realizations were simulated for three geochemical conditions: 1) spatially homogeneous reactive mineral surface area, 2) reactive surface area positively correlated to hydraulic heterogeneity, and 3) reactive surface area negatively correlated to hydraulic heterogeneity. Groundwater chemistry and the corresponding effective reaction rates were calculated at three transverse planes to quantify differences in plume evolution due to heterogeneity in mineral reaction rates and solute residence time (τ). The model is based on a hypothetical CO2 intrusion into groundwater from a carbon capture utilization and storage (CCUS) operation where CO2 dissolution and formation of carbonic acid created geochemical dis-equilibrium between fluids and the mineral galena that resulted in increased aqueous lead (Pb2 +) concentrations. Calcite dissolution buffered the pH change and created conditions of galena oversaturation, which then reduced lead concentrations along the flow path. Near the leak kinetic geochemical reactions control the release of solutes into the fluid, but further along the flow path mineral solubility controls solute concentrations. Simulation results demonstrate the impact of heterogeneous distribution of geochemical reactive surface area in coordination with physical heterogeneity on the effective reaction rate (Krxn,eff) and Pb2 + concentrations within the plume. Dissimilarities between ensemble Pb2 + concentration and Krxn,eff are attributed to how geochemical heterogeneity affects the time (τeq) and therefore advection distance (Leq) required for the system to re-establish geochemical equilibrium. Only after geochemical equilibrium is re-established, Krxn,eff and Pb2 + concentrations are the same for all three
Emergence of Collagen Orientation Heterogeneity in Healing Infarcts and an Agent-Based Model.
Richardson, William J; Holmes, Jeffrey W
2016-05-24
Spatial heterogeneity of matrix structure can be an important determinant of tissue function. Although bulk properties of collagen structure in healing myocardial infarcts have been characterized previously, regional heterogeneity in infarct structure has received minimal attention. Herein, we quantified regional variations of collagen and nuclear orientations over the initial weeks of healing after infarction in rats, and employed a computational model of infarct remodeling to test potential explanations for the heterogeneity we observed in vivo. Fiber and cell orientation maps were generated from infarct samples acquired previously at 1, 2, 3, and 6 weeks postinfarction in a rat ligation model. We analyzed heterogeneity by calculating the dot product of each fiber or cell orientation vector with every other fiber or cell orientation vector, and plotting that dot product versus distance between the fibers or cells. This analysis revealed prominent regional heterogeneity, with alignment of both fibers and cell nuclei in local pockets far exceeding the global average. Using an agent-based model of fibroblast-mediated collagen remodeling, we found that similar levels of heterogeneity can spontaneously emerge from initially isotropic matrix via locally reinforcing cell-matrix interactions. Specifically, cells that sensed fiber orientation at a distance or remodeled fibers at a distance by traction-mediated reorientation or aligned deposition gave rise to regionally heterogeneous structures. However, only the simulations in which cells deposited collagen fibers aligned with their own orientation reproduced experimentally measured patterns of heterogeneity across all time points. These predictions warrant experimental follow-up to test the role of such mechanisms in vivo and identify opportunities to control heterogeneity for therapeutic benefit. PMID:27224491
Atchley, Adam L; Navarre-Sitchler, Alexis K; Maxwell, Reed M
2014-09-01
The role of coupled physical and geochemical heterogeneities in hydro-geochemical transport is investigated by simulating three-dimensional transport in a heterogeneous system with kinetic mineral reactions. Ensembles of 100 physically heterogeneous realizations were simulated for three geochemical conditions: 1) spatially homogeneous reactive mineral surface area, 2) reactive surface area positively correlated to hydraulic heterogeneity, and 3) reactive surface area negatively correlated to hydraulic heterogeneity. Groundwater chemistry and the corresponding effective reaction rates were calculated at three transverse planes to quantify differences in plume evolution due to heterogeneity in mineral reaction rates and solute residence time (τ). The model is based on a hypothetical CO2 intrusion into groundwater from a carbon capture utilization and storage (CCUS) operation where CO2 dissolution and formation of carbonic acid created geochemical dis-equilibrium between fluids and the mineral galena that resulted in increased aqueous lead (Pb(2+)) concentrations. Calcite dissolution buffered the pH change and created conditions of galena oversaturation, which then reduced lead concentrations along the flow path. Near the leak kinetic geochemical reactions control the release of solutes into the fluid, but further along the flow path mineral solubility controls solute concentrations. Simulation results demonstrate the impact of heterogeneous distribution of geochemical reactive surface area in coordination with physical heterogeneity on the effective reaction rate (Krxn,eff) and Pb(2+) concentrations within the plume. Dissimilarities between ensemble Pb(2+) concentration and Krxn,eff are attributed to how geochemical heterogeneity affects the time (τeq) and therefore advection distance (Leq) required for the system to re-establish geochemical equilibrium. Only after geochemical equilibrium is re-established, Krxn,eff and Pb(2+) concentrations are the same for all
Feedback-induced phase transitions in active heterogeneous conductors.
Ocko, Samuel A; Mahadevan, L
2015-04-01
An active conducting medium is one where the resistance (conductance) of the medium is modified by the current (flow) and in turn modifies the flow, so that the classical linear laws relating current and resistance, e.g., Ohm's law or Darcy's law, are modified over time as the system itself evolves. We consider a minimal model for this feedback coupling in terms of two parameters that characterize the way in which addition or removal of matter follows a simple local (or nonlocal) feedback rule corresponding to either flow-seeking or flow-avoiding behavior. Using numerical simulations and a continuum mean field theory, we show that flow-avoiding feedback causes an initially uniform system to become strongly heterogeneous via a tunneling (channel-building) phase separation; flow-seeking feedback leads to an immuring (wall-building) phase separation. Our results provide a qualitative explanation for the patterning of active conducting media in natural systems, while suggesting ways to realize complex architectures using simple rules in engineered systems.
Feedback-Induced Phase Transitions in Active Heterogeneous Conductors
NASA Astrophysics Data System (ADS)
Ocko, Samuel A.; Mahadevan, L.
2015-04-01
An active conducting medium is one where the resistance (conductance) of the medium is modified by the current (flow) and in turn modifies the flow, so that the classical linear laws relating current and resistance, e.g., Ohm's law or Darcy's law, are modified over time as the system itself evolves. We consider a minimal model for this feedback coupling in terms of two parameters that characterize the way in which addition or removal of matter follows a simple local (or nonlocal) feedback rule corresponding to either flow-seeking or flow-avoiding behavior. Using numerical simulations and a continuum mean field theory, we show that flow-avoiding feedback causes an initially uniform system to become strongly heterogeneous via a tunneling (channel-building) phase separation; flow-seeking feedback leads to an immuring (wall-building) phase separation. Our results provide a qualitative explanation for the patterning of active conducting media in natural systems, while suggesting ways to realize complex architectures using simple rules in engineered systems.
Small scale flow processes in aqueous heterogeneous porous media
Rashidi, M.; Dickenson, E.
1996-04-01
Small scale flow processes in aqueous heterogeneous porous systems have been studied experimentally via novel nonintrusive fluorescence imaging techniques. The techniques involve 3D visualization and quantification of flow fields within a refractive index-matched transparent porous column. The refractive index-matching yields a transparent porous medium, free from any scattering and refraction at the solid-liquid interfaces, as a result allowing direct optical probing at any point within the porous system. By illuminating the porous regions within the column with a planar sheet of laser beam, flow processes through the porous medium can be observed microscopically, and qualitative and quantitative in-pore transport information can be obtained at a good resolution and a good accuracy. A CCD camera is used to record the fluorescent images at every vertical plane location while sweeping back and forth across the column. These digitized flow images are then analyzed and accumulated over a 3D volume within the column. Series of flow experiments in aqueous, refractive index-matched, porous systems packed with natural mineral particles have been performed successfully in these laboratories.
On the cosmic ray diffusion in a violent interstellar medium
NASA Astrophysics Data System (ADS)
Bykov, A. M.; Toptygin, I. N.
1985-08-01
A variety of the available observational data on the cosmic ray (CR) spectrum, anisotropy and composition are in good agreement with a suggestion on the diffusion propagation of CR with energy below 10(15) eV in the interstellar medium. The magnitude of the CR diffusion coefficient and its energy dependence are determined by interstellar medium (ISM) magnetic field spectra. Direct observational data on magnetic field spectra are still absent. A theoretical model to the turbulence generation in the multiphase ISM is resented. The model is based on the multiple generation of secondary shocks and concomitant large-scale rarefactions due to supernova shock interactions with interstellar clouds. The distribution function for ISM shocks are derived to include supernova statistics, diffuse cloud distribution, and various shock wave propagation regimes. This permits calculation of the ISM magnetic field fluctuation spectrum and CR diffusion coefficient for the hot phase of ISM.
Laser ablation of a turbid medium: Modeling and experimental results
Brygo, F.; Semerok, A.; Weulersse, J.-M.; Thro, P.-Y.; Oltra, R.
2006-08-01
Q-switched Nd:YAG laser ablation of a turbid medium (paint) is studied. The optical properties (absorption coefficient, scattering coefficient, and its anisotropy) of a paint are determined with a multiple scattering model (three-flux model), and from measurements of reflection-transmission of light through thin layers. The energy deposition profiles are calculated at wavelengths of 532 nm and 1.064 {mu}m. They are different from those described by a Lambert-Beer law. In particular, the energy deposition of the laser beam is not maximum on the surface but at some depth inside the medium. The ablated rate was measured for the two wavelengths and compared with the energy deposition profile predicted by the model. This allows us to understand the evolution of the ablated depth with the wavelength: the more the scattering coefficient is higher, the more the ablated depth and the threshold fluence of ablation decrease.
Spheroidizing of medium carbon steels
NASA Astrophysics Data System (ADS)
O'Brien, James Michael
2000-11-01
An investigation has been made of spheroidization of medium carbon steels used in the bolt industry. Two process cycles were considered. One was the intercritical cycle, widely used in industry, in which the steel was heated above the A1 temperature for approximately 2 hours and then cooled to 688°C (1270°F) and held for various periods. The other was a subcritical cycle that involved heating to 704°C (1300°F) for various times. Wire samples were 0.4-in. diameter AISI 1541, considered high in manganese and difficult to spheroidize. Although AISI 4037 is considered easier to spheroidize, this alloy was also tested due to its extensive industrial use. It was found that the intercritical cycle produced a somewhat faster drop in hardness. However, one hour of the subcritical cycle yielded greater ductility than 32 hours of the intercritical process, as measured by tensile tests. Similar ductility results were achieved using a new flare test. The level of spheroidization was defined in this study to be the percentage of carbide particles with aspect ratios less than 3. The subcritical cycle produced the same level of spheroidization in 1/2 hour as that reached by the intercritical cycle in 32 hours. Faster spheroidization of cementite plates in the subcritical process appears to be due to the fine pearlite generated by the current practice of rapid cooling off the hot mill. This advantage is lost in the intercritical process because the original pearlite is dissolved above the A1 temperature.