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Sample records for hierarchical multiple system

  1. OBSERVATIONS OF HIERARCHICAL SOLAR-TYPE MULTIPLE STAR SYSTEMS

    SciTech Connect

    Roberts, Lewis C. Jr.; Tokovinin, Andrei; Mason, Brian D.; Hartkopf, William I.; Riddle, Reed L.

    2015-10-15

    Twenty multiple stellar systems with solar-type primaries were observed at high angular resolution using the PALM-3000 adaptive optics system at the 5 m Hale telescope. The goal was to complement the knowledge of hierarchical multiplicity in the solar neighborhood by confirming recent discoveries by the visible Robo-AO system with new near-infrared observations with PALM-3000. The physical status of most, but not all, of the new pairs is confirmed by photometry in the Ks band and new positional measurements. In addition, we resolved for the first time five close sub-systems: the known astrometric binary in HIP 17129AB, companions to the primaries of HIP 33555, and HIP 118213, and the companions to the secondaries in HIP 25300 and HIP 101430. We place the components on a color–magnitude diagram and discuss each multiple system individually.

  2. Secular dynamics of hierarchical multiple systems composed of nested binaries, with an arbitrary number of bodies and arbitrary hierarchical structure. First applications to multiplanet and multistar systems

    NASA Astrophysics Data System (ADS)

    Hamers, Adrian S.; Portegies Zwart, Simon F.

    2016-07-01

    We present a method for studying the secular gravitational dynamics of hierarchical multiple systems consisting of nested binaries, which is valid for an arbitrary number of bodies and arbitrary hierarchical structure. We derive the Hamiltonian of the system and expand it in terms of the - assumed to be - small ratios xi of binary separations. At the lowest non-trivial expansion order (quadrupole order, second order in xi), the Hamiltonian consists of terms which, individually, depend on binary pairs. At higher orders, in addition to terms depending on binary pairs, we also find terms which, individually, depend on more than two binaries. In general, at order n in xi, individual terms depend on at most n - 1 binaries. We explicitly derive the Hamiltonian including all terms up and including third order in xi (octupole order), and including the binary pairwise terms up and including fifth order in xi. These terms are orbit averaged, and we present a new algorithm for efficiently solving the equations of motion. This algorithm is highly suitable for studying the secular evolution of hierarchical systems with complex hierarchies, making long-term integrations of such systems feasible. We show that accurate results are obtained for multiplanet systems with semimajor axis ratios as large as ≈0.4, provided that high-order terms are included. In addition to multiplanet systems with a single star, we apply our results to multistar systems with multiple planets.

  3. Application and Interpretation of Hierarchical Multiple Regression.

    PubMed

    Jeong, Younhee; Jung, Mi Jung

    2016-01-01

    The authors reported the association between motivation and self-management behavior of individuals with chronic low back pain after adjusting control variables using hierarchical multiple regression (). This article describes details of the hierarchical regression applying the actual data used in the article by , including how to test assumptions, run the statistical tests, and report the results. PMID:27648796

  4. HDS: Hierarchical Data System

    NASA Astrophysics Data System (ADS)

    Pearce, Dave; Walter, Anton; Lupton, W. F.; Warren-Smith, Rodney F.; Lawden, Mike; McIlwrath, Brian; Peden, J. C. M.; Jenness, Tim; Draper, Peter W.

    2015-02-01

    The Hierarchical Data System (HDS) is a file-based hierarchical data system designed for the storage of a wide variety of information. It is particularly suited to the storage of large multi-dimensional arrays (with their ancillary data) where efficient access is needed. It is a key component of the Starlink software collection (ascl:1110.012) and is used by the Starlink N-Dimensional Data Format (NDF) library (ascl:1411.023). HDS organizes data into hierarchies, broadly similar to the directory structure of a hierarchical filing system, but contained within a single HDS container file. The structures stored in these files are self-describing and flexible; HDS supports modification and extension of structures previously created, as well as functions such as deletion, copying, and renaming. All information stored in HDS files is portable between the machines on which HDS is implemented. Thus, there are no format conversion problems when moving between machines. HDS can write files in a private binary format (version 4), or be layered on top of HDF5 (version 5).

  5. Hierarchical regression for analyses of multiple outcomes.

    PubMed

    Richardson, David B; Hamra, Ghassan B; MacLehose, Richard F; Cole, Stephen R; Chu, Haitao

    2015-09-01

    In cohort mortality studies, there often is interest in associations between an exposure of primary interest and mortality due to a range of different causes. A standard approach to such analyses involves fitting a separate regression model for each type of outcome. However, the statistical precision of some estimated associations may be poor because of sparse data. In this paper, we describe a hierarchical regression model for estimation of parameters describing outcome-specific relative rate functions and associated credible intervals. The proposed model uses background stratification to provide flexible control for the outcome-specific associations of potential confounders, and it employs a hierarchical "shrinkage" approach to stabilize estimates of an exposure's associations with mortality due to different causes of death. The approach is illustrated in analyses of cancer mortality in 2 cohorts: a cohort of dioxin-exposed US chemical workers and a cohort of radiation-exposed Japanese atomic bomb survivors. Compared with standard regression estimates of associations, hierarchical regression yielded estimates with improved precision that tended to have less extreme values. The hierarchical regression approach also allowed the fitting of models with effect-measure modification. The proposed hierarchical approach can yield estimates of association that are more precise than conventional estimates when one wishes to estimate associations with multiple outcomes. PMID:26232395

  6. Hierarchical storage management system evaluation

    NASA Technical Reports Server (NTRS)

    Woodrow, Thomas S.

    1993-01-01

    The Numerical Aerodynamic Simulation (NAS) Program at NASA Ames Research Center has been developing a hierarchical storage management system, NAStore, for some 6 years. This evaluation compares functionality, performance, reliability, and other factors of NAStore and three commercial alternatives. FileServ is found to be slightly better overall than NAStore and DMF. UniTree is found to be severely lacking in comparison.

  7. Hierarchical Robot Control System and Method for Controlling Select Degrees of Freedom of an Object Using Multiple Manipulators

    NASA Technical Reports Server (NTRS)

    Abdallah, Muhammad E. (Inventor); Platt, Robert (Inventor); Wampler, II, Charles W. (Inventor)

    2013-01-01

    A robotic system includes a robot having manipulators for grasping an object using one of a plurality of grasp types during a primary task, and a controller. The controller controls the manipulators during the primary task using a multiple-task control hierarchy, and automatically parameterizes the internal forces of the system for each grasp type in response to an input signal. The primary task is defined at an object-level of control, e.g., using a closed-chain transformation, such that only select degrees of freedom are commanded for the object. A control system for the robotic system has a host machine and algorithm for controlling the manipulators using the above hierarchy. A method for controlling the system includes receiving and processing the input signal using the host machine, including defining the primary task at the object-level of control, e.g., using a closed-chain definition, and parameterizing the internal forces for each of grasp type.

  8. Hierarchical Data Assimilation for Multiple Source Uncertainty Estimation

    NASA Astrophysics Data System (ADS)

    Bastidas, L. A.; Tcherednichenko, I. A.; Hooten, M.

    2007-12-01

    Even the most intensive of today data-acquisition platforms cannot provide sufficient access to the spatial heterogeneity of geophysical system or the biological states of the environment and often are a source of conflicting information. Hydrologic models are laden, therefore, with a profusion of unobserved state variables. Reconciling model with observed behavior (inverse modeling) in order to improve understanding is quintessentially an issue of demonstrating, beyond reasonable doubt, that matching of the two approximations of the truth has not been achieved at the expense of imposing absurd values to the model parameters. We use a hierarchical data assimilation approach to provide a convenient mechanism for explicitly accounting for uncertainty by specifying manageable joint distributions that can be formulated by three separate components: Data Model, Process Model, and Parameter Model. In this way a quite complex joint statistical model can be specified in terms of a sequence of conditional models. For example, distinctly different data models can be specified so that they are conditioned on the same underlying process, and this underlying process can then be, in turn, specified so that it is conditioned on a set of model parameters. The hierarchical models also have the ability for explicit accounting of uncertainty in multiple components of the model. The specification of mechanistic models in the process component of a hierarchical framework explicitly assumes the model is wrong, but can account for this source of uncertainty by allowing for a quantifiable process model error term; at the same time, the framework allows the parameters pertaining to the distributional forms of the data models and process models to be random and directly accounts for their inherent uncertainty. The framework also allows for the incorporation of multiple data types within the same model (useful for simultaneous use of observations of natural processes in several distinct ways

  9. Hierarchical regression for epidemiologic analyses of multiple exposures.

    PubMed Central

    Greenland, S

    1994-01-01

    Many epidemiologic investigations are designed to study the effects of multiple exposures. Most of these studies are analyzed either by fitting a risk-regression model with all exposures forced in the model, or by using a preliminary-testing algorithm, such as stepwise regression, to produce a smaller model. Research indicates that hierarchical modeling methods can outperform these conventional approaches. These methods are reviewed and compared to two hierarchical methods, empirical-Bayes regression and a variant here called "semi-Bayes" regression, to full-model maximum likelihood and to model reduction by preliminary testing. The performance of the methods in a problem of predicting neonatal-mortality rates are compared. Based on the literature to date, it is suggested that hierarchical methods should become part of the standard approaches to multiple-exposure studies. PMID:7851328

  10. Analysis hierarchical model for discrete event systems

    NASA Astrophysics Data System (ADS)

    Ciortea, E. M.

    2015-11-01

    The This paper presents the hierarchical model based on discrete event network for robotic systems. Based on the hierarchical approach, Petri network is analysed as a network of the highest conceptual level and the lowest level of local control. For modelling and control of complex robotic systems using extended Petri nets. Such a system is structured, controlled and analysed in this paper by using Visual Object Net ++ package that is relatively simple and easy to use, and the results are shown as representations easy to interpret. The hierarchical structure of the robotic system is implemented on computers analysed using specialized programs. Implementation of hierarchical model discrete event systems, as a real-time operating system on a computer network connected via a serial bus is possible, where each computer is dedicated to local and Petri model of a subsystem global robotic system. Since Petri models are simplified to apply general computers, analysis, modelling, complex manufacturing systems control can be achieved using Petri nets. Discrete event systems is a pragmatic tool for modelling industrial systems. For system modelling using Petri nets because we have our system where discrete event. To highlight the auxiliary time Petri model using transport stream divided into hierarchical levels and sections are analysed successively. Proposed robotic system simulation using timed Petri, offers the opportunity to view the robotic time. Application of goods or robotic and transmission times obtained by measuring spot is obtained graphics showing the average time for transport activity, using the parameters sets of finished products. individually.

  11. A hierarchical modeling framework for multiple observer transect surveys.

    PubMed

    Conn, Paul B; Laake, Jeffrey L; Johnson, Devin S

    2012-01-01

    Ecologists often use multiple observer transect surveys to census animal populations. In addition to animal counts, these surveys produce sequences of detections and non-detections for each observer. When combined with additional data (i.e. covariates such as distance from the transect line), these sequences provide the additional information to estimate absolute abundance when detectability on the transect line is less than one. Although existing analysis approaches for such data have proven extremely useful, they have some limitations. For instance, it is difficult to extrapolate from observed areas to unobserved areas unless a rigorous sampling design is adhered to; it is also difficult to share information across spatial and temporal domains or to accommodate habitat-abundance relationships. In this paper, we introduce a hierarchical modeling framework for multiple observer line transects that removes these limitations. In particular, abundance intensities can be modeled as a function of habitat covariates, making it easier to extrapolate to unsampled areas. Our approach relies on a complete data representation of the state space, where unobserved animals and their covariates are modeled using a reversible jump Markov chain Monte Carlo algorithm. Observer detections are modeled via a bivariate normal distribution on the probit scale, with dependence induced by a distance-dependent correlation parameter. We illustrate performance of our approach with simulated data and on a known population of golf tees. In both cases, we show that our hierarchical modeling approach yields accurate inference about abundance and related parameters. In addition, we obtain accurate inference about population-level covariates (e.g. group size). We recommend that ecologists consider using hierarchical models when analyzing multiple-observer transect data, especially when it is difficult to rigorously follow pre-specified sampling designs. We provide a new R package, hierarchical

  12. Efficient hierarchical interconnection for multiprocessor systems

    NASA Technical Reports Server (NTRS)

    Wei, Sizheng; Levy, Saul

    1992-01-01

    The authors present a novel approach to the design of a class of hierarchical interconnection networks for multiprocessor systems. This approach, based on an architecture providing separate networks for each level, gives a general and flexible way to construct efficient hierarchical networks. The performance and cost-effectiveness of the resulting networks are analyzed and compared in detail, using both unbuffered and buffered network models. It is shown that, if the design parameters are determined based on the degree of locality, the cost-effectiveness of a hierarchical network can be significantly improved. In addition, the authors investigate how to construct a cost-effectiveness hierarchical network by determining appropriate design parameters. Two associated algorithms are developed for this purpose.

  13. From binaries to multiples. II. Hierarchical multiplicity of F and G dwarfs

    SciTech Connect

    Tokovinin, Andrei

    2014-04-01

    Statistics of hierarchical multiplicity among solar-type dwarfs are studied using the distance-limited sample of 4847 targets presented in the accompanying Paper I. Known facts about binaries (multiplicity fraction 0.46, lognormal period distribution with median period 100 yr and logarithmic dispersion 2.4, and nearly uniform mass-ratio distribution independent of the period) are confirmed with a high statistical significance. The fraction of hierarchies with three or more components is 0.13 ± 0.01, and the fractions of targets with n = 1, 2, 3, ... components are 54:33:8:4:1. Subsystems in the secondary components are almost as frequent as in the primary components, but in half of such cases both inner pairs are present. The high frequency of those 2+2 hierarchies (4%) suggests that both inner pairs were formed by a common process. The statistics of hierarchies can be reproduced by simulations, assuming that the field is a mixture coming from binary-rich and binary-poor environments. Periods of the outer and inner binaries are selected recursively from the same lognormal distribution, subject to the stability constraint and accounting for the correlation between inner subsystems. The simulator can be used to evaluate the frequency of multiple systems with specified parameters. However, it does not reproduce the observed excess of inner periods shorter than 10 days, caused by tidal evolution.

  14. Multiple System Atrophy

    MedlinePlus

    ... Enhancing Diversity Find People About NINDS NINDS Multiple System Atrophy Information Page Condensed from Multiple System Atrophy ... Trials Organizations Publicaciones en Español What is Multiple System Atrophy? Multiple system atrophy (MSA) is a progressive ...

  15. A self-defining hierarchical data system

    NASA Technical Reports Server (NTRS)

    Bailey, J.

    1992-01-01

    The Self-Defining Data System (SDS) is a system which allows the creation of self-defining hierarchical data structures in a form which allows the data to be moved between different machine architectures. Because the structures are self-defining they can be used for communication between independent modules in a distributed system. Unlike disk-based hierarchical data systems such as Starlink's HDS, SDS works entirely in memory and is very fast. Data structures are created and manipulated as internal dynamic structures in memory managed by SDS itself. A structure may then be exported into a caller supplied memory buffer in a defined external format. This structure can be written as a file or sent as a message to another machine. It remains static in structure until it is reimported into SDS. SDS is written in portable C and has been run on a number of different machine architectures. Structures are portable between machines with SDS looking after conversion of byte order, floating point format, and alignment. A Fortran callable version is also available for some machines.

  16. Modeling urban air pollution with optimized hierarchical fuzzy inference system.

    PubMed

    Tashayo, Behnam; Alimohammadi, Abbas

    2016-10-01

    Environmental exposure assessments (EEA) and epidemiological studies require urban air pollution models with appropriate spatial and temporal resolutions. Uncertain available data and inflexible models can limit air pollution modeling techniques, particularly in under developing countries. This paper develops a hierarchical fuzzy inference system (HFIS) to model air pollution under different land use, transportation, and meteorological conditions. To improve performance, the system treats the issue as a large-scale and high-dimensional problem and develops the proposed model using a three-step approach. In the first step, a geospatial information system (GIS) and probabilistic methods are used to preprocess the data. In the second step, a hierarchical structure is generated based on the problem. In the third step, the accuracy and complexity of the model are simultaneously optimized with a multiple objective particle swarm optimization (MOPSO) algorithm. We examine the capabilities of the proposed model for predicting daily and annual mean PM2.5 and NO2 and compare the accuracy of the results with representative models from existing literature. The benefits provided by the model features, including probabilistic preprocessing, multi-objective optimization, and hierarchical structure, are precisely evaluated by comparing five different consecutive models in terms of accuracy and complexity criteria. Fivefold cross validation is used to assess the performance of the generated models. The respective average RMSEs and coefficients of determination (R (2)) for the test datasets using proposed model are as follows: daily PM2.5 = (8.13, 0.78), annual mean PM2.5 = (4.96, 0.80), daily NO2 = (5.63, 0.79), and annual mean NO2 = (2.89, 0.83). The obtained results demonstrate that the developed hierarchical fuzzy inference system can be utilized for modeling air pollution in EEA and epidemiological studies.

  17. Hierarchical organization of macaque and cat cortical sensory systems explored with a novel network processor.

    PubMed Central

    Hilgetag, C C; O'Neill, M A; Young, M P

    2000-01-01

    subdivision of FST into two distinct areas, whose connectivity we predict, and the abolition of at least one of the less reliable rule constraints. Our analyses showed that the future collection of the same type of laminar constraints, or the inclusion of new hierarchical constraints from thalamocortical connections, will not resolve the problem of multiple optimal hierarchical representations for the primate visual system. Further data, however, may help to specify the relative ordering of some more areas. This indeterminacy of the visual hierarchy is in part due to the reported absence of some connections between cortical areas. These absences are consistent with limited cross-talk between differentiated processing streams in the system. Hence, hierarchical representation of the visual system is affected by, and must take into account, other organizational features, such as processing streams. PMID:10703045

  18. Hierarchical structure of noncanonical Hamiltonian systems

    NASA Astrophysics Data System (ADS)

    Yoshida, Z.; Morrison, P. J.

    2016-02-01

    Topological constraints play a key role in the self-organizing processes that create structures in macro systems. In fact, if all possible degrees of freedom are actualized on equal footing without constraint, the state of ‘equipartition’ may bear no specific structure. Fluid turbulence is a typical example—while turbulent mixing seems to increase entropy, a variety of sustained vortical structures can emerge. In Hamiltonian formalism, some topological constraints are represented by Casimir invariants (for example, helicities of a fluid or a plasma), and then, the effective phase space is reduced to the Casimir leaves. However, a general constraint is not necessarily integrable, which precludes the existence of an appropriate Casimir invariant; the circulation is an example of such an invariant. In this work, we formulate a systematic method to embed a Hamiltonian system in an extended phase space; we introduce phantom fields and extend the Poisson algebra. A phantom field defines a new Casimir invariant, a cross helicity, which represents a topological constraint that is not integrable in the original phase space. Changing the perspective, a singularity of the extended system may be viewed as a subsystem on which the phantom fields (though they are actual fields, when viewed from the extended system) vanish, i.e., the original system. This hierarchical relation of degenerate Poisson manifolds enables us to see the ‘interior’ of a singularity as a sub Poisson manifold. The theory can be applied to describe bifurcations and instabilities in a wide class of general Hamiltonian systems (Yoshida and Morrison 2014 Fluid Dyn. Res. 46 031412).

  19. Multi-scale 2D tracking of articulated objects using hierarchical spring systems.

    PubMed

    Artner, Nicole M; Ion, Adrian; Kropatsch, Walter G

    2011-04-01

    This paper presents a flexible framework to build a target-specific, part-based representation for arbitrary articulated or rigid objects. The aim is to successfully track the target object in 2D, through multiple scales and occlusions. This is realized by employing a hierarchical, iterative optimization process on the proposed representation of structure and appearance. Therefore, each rigid part of an object is described by a hierarchical spring system represented by an attributed graph pyramid. Hierarchical spring systems encode the spatial relationships of the features (attributes of the graph pyramid) describing the parts and enforce them by spring-like behavior during tracking. Articulation points connecting the parts of the object allow to transfer position information from reliable to ambiguous parts. Tracking is done in an iterative process by combining the hypotheses of simple trackers with the hypotheses extracted from the hierarchical spring systems.

  20. Approaching Expert Results Using a Hierarchical Cerebellum Parcellation Protocol for Multiple Inexpert Human Raters

    PubMed Central

    Bogovic, John A.; Jedynak, Bruno; Rigg, Rachel; Du, Annie; Landman, Bennett A.; Prince, Jerry L.; Ying, Sarah H.

    2012-01-01

    Volumetric measurements obtained from image parcellation have been instrumental in uncovering structure-function relationships. However, anatomical study of the cerebellum is a challenging task. Because of its complex structure, expert human raters have been necessary for reliable and accurate segmentation and parcellation. Such delineations are time-consuming and prohibitively expensive for large studies. Therefore, we present a three-part cerebellar parcellation system that utilizes multiple inexpert human raters that can efficiently and expediently produce results nearly on par with those of experts. This system includes a hierarchical delineation protocol, a rapid verification and evaluation process, and statistical fusion of the inexpert rater parcellations. The quality of the raters’ and fused parcellations was established by examining their Dice similarity coefficient, region of interest (ROI) volumes, and the intraclass correlation coefficient of region volume. The intra-rater ICC was found to be 0.93 at the finest level of parcellation. PMID:22975160

  1. Orbits of Subsystems in Four Hierarchical Multiple Stars

    NASA Astrophysics Data System (ADS)

    Tokovinin, Andrei

    2016-07-01

    Seven spectroscopic orbits in nearby solar-type multiple stars are presented. The primary of the chromospherically active star HIP 9642 is a 4.8 day double-lined pair; the outer 420 year visual orbit is updated, but remains poorly constrained. HIP 12780 is a quadruple system consisting of the resolved 6.7 year pair FIN 379 Aa,Ab, for which the combined orbit, masses, and orbital parallax are determined here, and the single-lined binary Ba,Bb with a period of 27.8 days. HIP 28790 is a young quintuple system composed of two close binaries, Aa,Ab and Ba,Bb, with periods of 221 and 13 days, respectively, and a single distant component C. Its subsystem Ba,Bb is peculiar, having a spectroscopic mass ratio of 0.89 but a magnitude difference of ˜2.2 mag. HIP 64478 also contains five stars: the A-component is a 29 year visual pair with a previously known 4 day twin subsystem, while the B-component is a contact binary with a period of 5.8 hr, seen nearly pole-on.

  2. Multiple Object Retrieval in Image Databases Using Hierarchical Segmentation Tree

    ERIC Educational Resources Information Center

    Chen, Wei-Bang

    2012-01-01

    The purpose of this research is to develop a new visual information analysis, representation, and retrieval framework for automatic discovery of salient objects of user's interest in large-scale image databases. In particular, this dissertation describes a content-based image retrieval framework which supports multiple-object retrieval. The…

  3. What Is Wrong with ANOVA and Multiple Regression? Analyzing Sentence Reading Times with Hierarchical Linear Models

    ERIC Educational Resources Information Center

    Richter, Tobias

    2006-01-01

    Most reading time studies using naturalistic texts yield data sets characterized by a multilevel structure: Sentences (sentence level) are nested within persons (person level). In contrast to analysis of variance and multiple regression techniques, hierarchical linear models take the multilevel structure of reading time data into account. They…

  4. Standardization of a Hierarchical Transactive Control System

    SciTech Connect

    Hammerstrom, Donald J.; Oliver, Terry V.; Melton, Ronald B.; Ambrosio, Ron

    2010-12-03

    The authors describe work they have conducted toward the generalization and standardization of the transactive control approach that was first demonstrated in the Olympic Peninsula Project for the management of a transmission constraint. The newly generalized approach addresses several potential shortfalls of the prior approach: First, the authors have formalized a hierarchical node structure which defines the nodes and the functional signal pathways between these nodes. Second, by fully generalizing the inputs, outputs, and functional responsibilities of each node, the authors make the approach available to a much wider set of responsive assets and operational objectives. Third, the new, generalized approach defines transactive signals that include the predicted day-ahead future. This predictive feature allows the market-like bids and offers to become resolved iteratively over time, thus allowing the behaviors of responsive assets to be called upon both for the present and as future dispatch decisions are being made. The hierarchical transactive control approach is a key feature of a proposed Pacific Northwest smart grid demonstration.

  5. Hierarchical Discrete Event Supervisory Control of Aircraft Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Yasar, Murat; Tolani, Devendra; Ray, Asok; Shah, Neerav; Litt, Jonathan S.

    2004-01-01

    This paper presents a hierarchical application of Discrete Event Supervisory (DES) control theory for intelligent decision and control of a twin-engine aircraft propulsion system. A dual layer hierarchical DES controller is designed to supervise and coordinate the operation of two engines of the propulsion system. The two engines are individually controlled to achieve enhanced performance and reliability, necessary for fulfilling the mission objectives. Each engine is operated under a continuously varying control system that maintains the specified performance and a local discrete-event supervisor for condition monitoring and life extending control. A global upper level DES controller is designed for load balancing and overall health management of the propulsion system.

  6. Optimization by decomposition: A step from hierarchic to non-hierarchic systems

    NASA Technical Reports Server (NTRS)

    Sobieszczanski-Sobieski, Jaroslaw

    1988-01-01

    A new, non-hierarchic decomposition is formulated for system optimization that uses system analysis, system sensitivity analysis, temporary decoupled optimizations performed in the design subspaces corresponding to the disciplines and subsystems, and a coordination optimization concerned with the redistribution of responsibility for the constraint satisfaction and design trades among the disciplines and subsystems. The approach amounts to a variation of the well-known method of subspace optimization modified so that the analysis of the entire system is eliminated from the subspace optimization and the subspace optimizations may be performed concurrently.

  7. Linking landscape characteristics to local grizzly bear abundance using multiple detection methods in a hierarchical model

    USGS Publications Warehouse

    Graves, T.A.; Kendall, K.C.; Royle, J. Andrew; Stetz, J.B.; Macleod, A.C.

    2011-01-01

    Few studies link habitat to grizzly bear Ursus arctos abundance and these have not accounted for the variation in detection or spatial autocorrelation. We collected and genotyped bear hair in and around Glacier National Park in northwestern Montana during the summer of 2000. We developed a hierarchical Markov chain Monte Carlo model that extends the existing occupancy and count models by accounting for (1) spatially explicit variables that we hypothesized might influence abundance; (2) separate sub-models of detection probability for two distinct sampling methods (hair traps and rub trees) targeting different segments of the population; (3) covariates to explain variation in each sub-model of detection; (4) a conditional autoregressive term to account for spatial autocorrelation; (5) weights to identify most important variables. Road density and per cent mesic habitat best explained variation in female grizzly bear abundance; spatial autocorrelation was not supported. More female bears were predicted in places with lower road density and with more mesic habitat. Detection rates of females increased with rub tree sampling effort. Road density best explained variation in male grizzly bear abundance and spatial autocorrelation was supported. More male bears were predicted in areas of low road density. Detection rates of males increased with rub tree and hair trap sampling effort and decreased over the sampling period. We provide a new method to (1) incorporate multiple detection methods into hierarchical models of abundance; (2) determine whether spatial autocorrelation should be included in final models. Our results suggest that the influence of landscape variables is consistent between habitat selection and abundance in this system. ?? 2011 The Authors. Animal Conservation ?? 2011 The Zoological Society of London.

  8. Latent Variable Regression 4-Level Hierarchical Model Using Multisite Multiple-Cohorts Longitudinal Data. CRESST Report 801

    ERIC Educational Resources Information Center

    Choi, Kilchan

    2011-01-01

    This report explores a new latent variable regression 4-level hierarchical model for monitoring school performance over time using multisite multiple-cohorts longitudinal data. This kind of data set has a 4-level hierarchical structure: time-series observation nested within students who are nested within different cohorts of students. These…

  9. Control of discrete event systems modeled as hierarchical state machines

    NASA Technical Reports Server (NTRS)

    Brave, Y.; Heymann, M.

    1991-01-01

    The authors examine a class of discrete event systems (DESs) modeled as asynchronous hierarchical state machines (AHSMs). For this class of DESs, they provide an efficient method for testing reachability, which is an essential step in many control synthesis procedures. This method utilizes the asynchronous nature and hierarchical structure of AHSMs, thereby illustrating the advantage of the AHSM representation as compared with its equivalent (flat) state machine representation. An application of the method is presented where an online minimally restrictive solution is proposed for the problem of maintaining a controlled AHSM within prescribed legal bounds.

  10. Hierarchical structure of biological systems: a bioengineering approach.

    PubMed

    Alcocer-Cuarón, Carlos; Rivera, Ana L; Castaño, Victor M

    2014-01-01

    A general theory of biological systems, based on few fundamental propositions, allows a generalization of both Wierner and Berthalanffy approaches to theoretical biology. Here, a biological system is defined as a set of self-organized, differentiated elements that interact pair-wise through various networks and media, isolated from other sets by boundaries. Their relation to other systems can be described as a closed loop in a steady-state, which leads to a hierarchical structure and functioning of the biological system. Our thermodynamical approach of hierarchical character can be applied to biological systems of varying sizes through some general principles, based on the exchange of energy information and/or mass from and within the systems.

  11. An hierarchical approach to performance evaluation of expert systems

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Kavi, Srinu

    1985-01-01

    The number and size of expert systems is growing rapidly. Formal evaluation of these systems - which is not performed for many systems - increases the acceptability by the user community and hence their success. Hierarchical evaluation that had been conducted for computer systems is applied for expert system performance evaluation. Expert systems are also evaluated by treating them as software systems (or programs). This paper reports many of the basic concepts and ideas in the Performance Evaluation of Expert Systems Study being conducted at the University of Southwestern Louisiana.

  12. P2MP MPLS-Based Hierarchical Service Management System

    NASA Astrophysics Data System (ADS)

    Kumaki, Kenji; Nakagawa, Ikuo; Nagami, Kenichi; Ogishi, Tomohiko; Ano, Shigehiro

    This paper proposes a point-to-multipoint (P2MP) Multi-Protocol Label Switching (MPLS) based hierarchical service management system. Traditionally, general management systems deployed in some service providers control MPLS Label Switched Paths (LSPs) (e.g., RSVP-TE and LDP) and services (e.g., L2VPN, L3VPN and IP) separately. In order for dedicated management systems for MPLS LSPs and services to cooperate with each other automatically, a hierarchical service management system has been proposed with the main focus on point-to-point (P2P) TE LSPs in MPLS path management. In the case where P2MP TE LSPs and services are deployed in MPLS networks, the dedicated management systems for P2MP TE LSPs and services must work together automatically. Therefore, this paper proposes a new algorithm that uses a correlation between P2MP TE LSPs and multicast VPN services based on a P2MP MPLS-based hierarchical service management architecture. Also, the capacity and performance of the proposed algorithm are evaluated by simulations, which are actually based on certain real MPLS production networks, and are compared to that of the algorithm for P2P TE LSPs. Results show this system is very scalable within real MPLS production networks. This system, with the automatic correlation, appears to be deployable in real MPLS production networks.

  13. Heuristic decomposition for non-hierarchic systems

    NASA Technical Reports Server (NTRS)

    Bloebaum, Christina L.; Hajela, P.

    1991-01-01

    Design and optimization is substantially more complex in multidisciplinary and large-scale engineering applications due to the existing inherently coupled interactions. The paper introduces a quasi-procedural methodology for multidisciplinary optimization that is applicable for nonhierarchic systems. The necessary decision-making support for the design process is provided by means of an embedded expert systems capability. The method employs a decomposition approach whose modularity allows for implementation of specialized methods for analysis and optimization within disciplines.

  14. Proposal for hierarchical description of software systems

    NASA Technical Reports Server (NTRS)

    Thauboth, H.

    1973-01-01

    The programming of digital computers has developed into a new dimension full of diffculties, because the hardware of computers has become so powerful that more complex applications are entrusted to computers. The costs of software development, verification, and maintenance are outpacing those of the hardware and the trend is toward futher increase of sophistication of application of computers and consequently of sophistication of software. To obtain better visibility into software systems and to improve the structure of software systems for better tests, verification, and maintenance, a clear, but rigorous description and documentation of software is needed. The purpose of the report is to extend the present methods in order to obtain a documentation that better reflects the interplay between the various components and functions of a software system at different levels of detail without losing the precision in expression. This is done by the use of block diagrams, sequence diagrams, and cross-reference charts. In the appendices, examples from an actual large sofware system, i.e. the Marshall System for Aerospace Systems Simulation (MARSYAS), are presented. The proposed documentation structure is compatible to automation of updating significant portions of the documentation for better software change control.

  15. Hierarchical security system using real-valued data and orthogonal code in Fourier domain

    NASA Astrophysics Data System (ADS)

    Kim, Hyun-Jun; Seo, Dong-Hoan; Hwang, Kwang-Il; Lim, Tae-Woo

    2014-02-01

    We propose a novel hierarchical encryption scheme using orthogonal code in Fourier domain and decryption based on interferometer system. The proposed system is composed of hierarchical ciphertexts with positive real values which can be applied for practical transmission such as Internet, and decryption keys with real valued function which has orthogonal characteristic in the decryption system. Since the original information is encrypted on the Fourier plane, the proposed encryption is more tolerant to loss of key information by scratching or cutting than encryption in a spatial domain. The resulting image using Fourier transform and an interferometer system with constant phase retarder is then decrypted by use of a ciphertext with different security level and each of decryption keys made from the multiplication of orthogonal code and random phase code in order to enhance the level of security. We demonstrate the efficiency of the proposed method and the fault-tolerance properties of data loss through several simulations.

  16. Hierarchical Dynamical Information Systems With a Focus on Biology

    NASA Astrophysics Data System (ADS)

    Collier, John

    2003-06-01

    A system of a number of relatively stable units that can combine more or less freely to form somewhat less stable structures has a capacity to carry information in a more or less arbitrary way. I call such a system a physical information system if its properties are dynamically specified. All physical information systems have certain general dynamical properties. DNA can form such a system, but so can, to a lesser degree, RNA, proteins, cells and cellular subsystems, various immune system elements, organisms in populations and in ecosystems, as well as other higher-level phenomena. These systems are hierarchical structures with respect to the expression of lower level information at higher levels. This allows a distinction between macro and microstates within the system, with resulting statistical (entropy driven) dynamics, including the possibility of self-organization, system bifurcation, and the formation of higher levels of information expression. Although lower-level information is expressed in an information hierarchy, this in itself is not sufficient for reference, function, or meaning. Nonetheless, the expression of information is central to the realization of all of these. 'Biological information' is thus ambiguous between syntactic information in a hierarchical modular system, and functional information. However, the dynamics of hierarchical physical information systems is of interest to the study of how functional information might be embodied physically. I will address 1) how to tighten the relative terms in the characterizations of 'information system' and 'informational hierarchy' above, 2) how to distinguish between components of an information system combining to form more complex informational modules and the expression of information, 3) some aspects of the dynamics of such systems that are of biological interest, 4) why information expression in such systems is not sufficient for functional information, and 5) what further might be required for

  17. Distribution system reliability assessment using hierarchical Markov modeling

    SciTech Connect

    Brown, R.E.; Gupta, S.; Christie, R.D.; Venkata, S.S.; Fletcher, R.

    1996-10-01

    Distribution system reliability assessment is concerned with power availability and power quality at each customer`s service entrance. This paper presents a new method, termed Hierarchical Markov Modeling (HMM), which can perform predictive distribution system reliability assessment. HMM is unique in that it decomposes the reliability model based on system topology, integrated protection systems, and individual protection devices. This structure, which easily accommodates the effects of backup protection, fault isolation, and load restoration, is compared to simpler reliability models. HMM is then used to assess the reliability of an existing utility distribution system and to explore the reliability impact of several design improvement options.

  18. A Hierarchical Systems Approach to Model Validation

    NASA Astrophysics Data System (ADS)

    Easterbrook, S. M.

    2011-12-01

    Existing approaches to the question of how climate models should be evaluated tend to rely on either philosophical arguments about the status of models as scientific tools, or on empirical arguments about how well runs from a given model match observational data. These have led to quantitative approaches expressed in terms of model bias or forecast skill, and ensemble approaches where models are assessed according to the extent to which the ensemble brackets the observational data. Unfortunately, such approaches focus the evaluation on models per se (or more specifically, on the simulation runs they produce) as though the models can be isolated from their context. Such approach may overlook a number of important aspects of the use of climate models: - the process by which models are selected and configured for a given scientific question. - the process by which model outputs are selected, aggregated and interpreted by a community of expertise in climatology. - the software fidelity of the models (i.e. whether the running code is actually doing what the modellers think it's doing). - the (often convoluted) history that begat a given model, along with the modelling choices long embedded in the code. - variability in the scientific maturity of different model components within a coupled system. These omissions mean that quantitative approaches cannot assess whether a model produces the right results for the wrong reasons, or conversely, the wrong results for the right reasons (where, say the observational data is problematic, or the model is configured to be unlike the earth system for a specific reason). Hence, we argue that it is a mistake to think that validation is a post-hoc process to be applied to an individual "finished" model, to ensure it meets some criteria for fidelity to the real world. We are therefore developing a framework for model validation that extends current approaches down into the detailed codebase and the processes by which the code is built

  19. Random walk on p-adics and hierarchical systems

    SciTech Connect

    Lukierska-Walasek, K.; Topolski, K.

    2006-02-01

    We show that p-adic analysis provides a quite natural basis for the description of relaxation in hierarchical systems. For our purposes, we specify the Markov stochastic process considered by Albeverio and Karwowski. As a result we have obtained a random walk on the p-adic integer numbers, which provides the generalization of Cayley tree proposed by Ogielski and Stein. The temperature-dependent power-law decay and the Kohlrausch law are derived.

  20. A Petri net controller for distributed hierarchical systems. Thesis

    NASA Technical Reports Server (NTRS)

    Peck, Joseph E.

    1991-01-01

    The solutions to a wide variety of problems are often best organized as a distributed hierarchical system. These systems can be graphically and mathematically modeled through the use of Petri nets, which can easily represent synchronous, asynchronous, and concurrent operations. This thesis presents a controller implementation based on Petri nets and a design methodology for the interconnection of distributed Petri nets. Two case studies are presented in which the controller operates a physical system, the Center for Intelligent Robotic Systems for Space Exploration Dual Arm Robotic Testbed.

  1. Reimplementing the Hierarchical Data System using HDF5

    NASA Astrophysics Data System (ADS)

    Jenness, Tim

    2015-09-01

    The Starlink Hierarchical Data System has been a very successful niche astronomy file format and library for over 30 years. Development of the library was frozen ten years ago when funding for Starlink was stopped and almost no-one remains who understands the implementation details. To ensure the long-term sustainability of the Starlink application software and to make the extensible N-Dimensional Data Format accessible to a broader range of users, we propose to re-implement the HDS library application interface as a layer on top of the Hierarchical Data Format version 5. We present an overview of the new implementation of version 5 of the HDS file format and describe differences between the expectations of the HDS and HDF5 library interfaces. We finish by comparing the old and new HDS implementations by looking at a comparison of file sizes and by comparing performance benchmarks.

  2. Compiler-Directed File Layout Optimization for Hierarchical Storage Systems

    DOE PAGESBeta

    Ding, Wei; Zhang, Yuanrui; Kandemir, Mahmut; Son, Seung Woo

    2013-01-01

    File layout of array data is a critical factor that effects the behavior of storage caches, and has so far taken not much attention in the context of hierarchical storage systems. The main contribution of this paper is a compiler-driven file layout optimization scheme for hierarchical storage caches. This approach, fully automated within an optimizing compiler, analyzes a multi-threaded application code and determines a file layout for each disk-resident array referenced by the code, such that the performance of the target storage cache hierarchy is maximized. We tested our approach using 16 I/O intensive application programs and compared its performancemore » against two previously proposed approaches under different cache space management schemes. Our experimental results show that the proposed approach improves the execution time of these parallel applications by 23.7% on average.« less

  3. Hierarchical fuzzy control of low-energy building systems

    SciTech Connect

    Yu, Zhen; Dexter, Arthur

    2010-04-15

    A hierarchical fuzzy supervisory controller is described that is capable of optimizing the operation of a low-energy building, which uses solar energy to heat and cool its interior spaces. The highest level fuzzy rules choose the most appropriate set of lower level rules according to the weather and occupancy information; the second level fuzzy rules determine an optimal energy profile and the overall modes of operation of the heating, ventilating and air-conditioning system (HVAC); the third level fuzzy rules select the mode of operation of specific equipment, and assign schedules to the local controllers so that the optimal energy profile can be achieved in the most efficient way. Computer simulation is used to compare the hierarchical fuzzy control scheme with a supervisory control scheme based on expert rules. The performance is evaluated by comparing the energy consumption and thermal comfort. (author)

  4. Modelling habitat associations with fingernail clam (Family: Sphaeriidae) counts at multiple spatial scales using hierarchical count models

    USGS Publications Warehouse

    Gray, B.R.; Haro, R.J.; Rogala, J.T.; Sauer, J.S.

    2005-01-01

    1. Macroinvertebrate count data often exhibit nested or hierarchical structure. Examples include multiple measurements along each of a set of streams, and multiple synoptic measurements from each of a set of ponds. With data exhibiting hierarchical structure, outcomes at both sampling (e.g. Within stream) and aggregated (e.g. Stream) scales are often of interest. Unfortunately, methods for modelling hierarchical count data have received little attention in the ecological literature. 2. We demonstrate the use of hierarchical count models using fingernail clam (Family: Sphaeriidae) count data and habitat predictors derived from sampling and aggregated spatial scales. The sampling scale corresponded to that of a standard Ponar grab (0.052 m(2)) and the aggregated scale to impounded and backwater regions within 38-197 km reaches of the Upper Mississippi River. Impounded and backwater regions were resampled annually for 10 years. Consequently, measurements on clams were nested within years. Counts were treated as negative binomial random variates, and means from each resampling event as random departures from the impounded and backwater region grand means. 3. Clam models were improved by the addition of covariates that varied at both the sampling and regional scales. Substrate composition varied at the sampling scale and was associated with model improvements, and reductions (for a given mean) in variance at the sampling scale. Inorganic suspended solids (ISS) levels, measured in the summer preceding sampling, also yielded model improvements and were associated with reductions in variances at the regional rather than sampling scales. ISS levels were negatively associated with mean clam counts. 4. Hierarchical models allow hierarchically structured data to be modelled without ignoring information specific to levels of the hierarchy. In addition, information at each hierarchical level may be modelled as functions of covariates that themselves vary by and within levels. As

  5. Discrete synchronization of massively connected systems using hierarchical couplings

    NASA Astrophysics Data System (ADS)

    Poignard, Camille

    2016-04-01

    We study the synchronization of massively connected dynamical systems for which the interactions come from the succession of couplings forming a global hierarchical coupling process. Motivations of this work come from the growing necessity of understanding properties of complex systems that often exhibit a hierarchical structure. Starting with a set of 2n systems, the couplings we consider represent a two-by-two matching process that gather them in larger and larger groups of systems, providing to the whole set a structure in n stages, corresponding to n scales of hierarchy. This leads us naturally to the synchronization of a Cantor set of systems, indexed by { 0 , 1 } N, using the closed-open sets defined by n-tuples of 0 and 1 that permit us to make the link with the finite previous situation of 2n systems: we obtain a global synchronization result generalizing this case. In the same context, we deal with this question when some defects appear in the hierarchy, that is to say when some couplings among certain systems do not happen at a given stage of the hierarchy. We prove we can accept an infinite number of broken links inside the hierarchy while keeping a local synchronization, under the condition that these defects are present at the N smallest scales of the hierarchy (for a fixed integer N) and they be enough spaced out in those scales.

  6. A Hierarchical Security Architecture for Cyber-Physical Systems

    SciTech Connect

    Quanyan Zhu; Tamer Basar

    2011-08-01

    Security of control systems is becoming a pivotal concern in critical national infrastructures such as the power grid and nuclear plants. In this paper, we adopt a hierarchical viewpoint to these security issues, addressing security concerns at each level and emphasizing a holistic cross-layer philosophy for developing security solutions. We propose a bottom-up framework that establishes a model from the physical and control levels to the supervisory level, incorporating concerns from network and communication levels. We show that the game-theoretical approach can yield cross-layer security strategy solutions to the cyber-physical systems.

  7. Hierarchical Multiple Regression Modelling on Predictors of Behavior and Sexual Practices at Takoradi Polytechnic, Ghana

    PubMed Central

    Turkson, Anthony Joe; Otchey, James Eric

    2015-01-01

    Introduction: Various psychosocial studies on health related lifestyles lay emphasis on the fact that the perception one has of himself as being at risk of HIV/AIDS infection was a necessary condition for preventive behaviors to be adopted. Hierarchical Multiple Regression models was used to examine the relationship between eight independent variables and one dependent variable to isolate predictors which have significant influence on behavior and sexual practices. Methods: A Cross-sectional design was used for the study. Structured close-ended interviewer-administered questionnaire was used to collect primary data. Multistage stratified technique was used to sample views from 380 students from Takoradi Polytechnic, Ghana. A Hierarchical multiple regression model was used to ascertain the significance of certain predictors of sexual behavior and practices. Results: The variables that were extracted from the multiple regression were; for the constant; β=14.202, t=2.279, p=0.023, variable is significant; for the marital status; β=0.092, t=1.996, p<0.05, variable is significant; for the knowledge on AIDs; β= 0.090, t=1.996, p<0.05, variable is significant; for the attitude towards HIV/AIDs; β=0.486, t=10.575, p<0.001, variable is highly significant. Thus, the best fitting model for predicting behavior and sexual practices was a linear combination of the constant, one’s marital status, knowledge on HIV/AIDs and Attitude towards HIV/AIDs., Y (Behavior and sexual practices) = β0 + β1 (Marital status) + β2 (Knowledge on HIV AIDs issues) + β3 (Attitude towards HIV AIDs issues) β0, β1, β2 and β3 are respectively 14.201, 2.038, 0.148 and 0.486; the higher the better. Conclusions: Attitude and behavior change education on HIV/AIDs should be intensified in the institution so that students could adopt better lifestyles. PMID:25946917

  8. Virial statistical description of non-extensive hierarchical systems

    NASA Astrophysics Data System (ADS)

    Pfenniger, Daniel

    2006-04-01

    In a first part the scope of classical thermodynamics and statistical mechanics is discussed in the broader context of formal dynamical systems, including computer programmes. In this context classical thermodynamics appears as a particular theory suited to a subset of all dynamical systems. A statistical mechanics similar to the one derived with the microcanonical ensemble emerges from dynamical systems provided it contains, (1) a finite non-integrable part of its phase space which is, (2) ergodic at a satisfactory degree after a finite time. The integrable part of phase space provides the constraints that shape the particular system macroscopical properties, and the chaotic part provides well behaved statistical properties over a relevant finite time. More generic semi-ergodic systems lead to intermittent behaviour, thus may be unsuited for a statistical description of steady states. Following these lines of thought, in a second part non-extensive hierarchical systems with statistical scale-invariance and power law interactions are explored. Only the virial constraint, consistent with their microdynamics, is included. No assumptions of classical thermodynamics are used, in particular extensivity and local homogeneity. In the limit of a large hierarchical range new constraints emerge in some conditions that depend on the interaction law range. In particular for the gravitational case, a velocity-size scaling relation is derived which is consistent with the ones empirically observed in the fractal interstellar medium. To cite this article: D. Pfenniger, C. R. Physique 7 (2006).

  9. Bayesian Hierarchical Model for Multiple Repeated Measures and Survival Data: an application to Parkinson's Disease

    PubMed Central

    Luo, Sheng; Wang, Jue

    2014-01-01

    Multilevel item response theory (MLIRT) models have been increasingly used to analyze the multivariate longitudinal data of mixed types (e.g., continuous and categorical) in clinical studies. To address the possible correlation between multivariate longitudinal measures and time to terminal events (e.g., death and dropout), joint models that consist of a MLIRT submodel and a survival submodel have been previously developed. However, in multisite studies, multiple patients are recruited and treated by the same clinical site. There can be a significant site correlation because of common environmental and socioeconomic status, and similar quality of care within site. In this article, we develop and study several hierarchical joint models with the hazard of terminal events dependent on shared random effects from various levels. We conduct extensive simulation study to evaluate the performance of various models under different scenarios. The proposed hierarchical joint models are applied to the motivating DATATOP study to investigate the effect of tocopherol in slowing PD progression. PMID:24935619

  10. Stress generation and hierarchical fracturing in reactive systems

    NASA Astrophysics Data System (ADS)

    Jamtveit, B.; Iyer, K.; Royne, A.; Malthe-Sorenssen, A.; Mathiesen, J.; Feder, J.

    2007-12-01

    Hierarchical fracture patterns are the result of a slowly driven fracturing process that successively divides the rocks into smaller domains. In quasi-2D systems, such fracture patterns are characterized by four sided domains, and T-junctions where new fractures stop at right angles to pre-existing fractures. We describe fracturing of mm to dm thick enstatite layers in a dunite matrix from the Leka ophiolite complex in Norway. The fracturing process is driven by expansion of the dunite matrix during serpentinization. The cumulative distributions of fracture lengths show a scaling behavior that lies between a log - normal and power law (fractal) distribution. This is consistent with a simple fragmentation model in which domains are divided according to a 'top hat' distribution of new fracture positions within unfractured domains. Reaction-assisted hierarchical fracturing is also likely to be responsible for other (3-D) structures commonly observed in serpentinized ultramafic rocks, including the mesh-textures observed in individual olivine grains, and the high abundance of rectangular domains at a wide range of scales. Spectacular examples of 3-D hierarchical fracture patterns also form during the weathering of basaltic intrusions (dolerites). Incipient chemical weathering of dolerites in the Karoo Basin in South Africa occurs around water- filled fractures, originally produced by thermal contraction or by externally imposed stresses. This chemical weathering causes local expansion of the rock matrix and generates elastic stresses. On a mm to cm scale, these stresses lead to mechanical layer-by-layer spalling, producing the characteristic spheroidal weathering patterns. However, our field observations and computer simulations demonstrate that in confined environments, the spalling process alone is unable to relieve the elastic stresses. In such cases, chemical weathering drives a much larger scale hierarchical fracturing process in which fresh dolerite undergoes a

  11. DISTURBANCE PATTERNS IN A SOCIO-ECOLOGICAL SYSTEM AT MULTIPLE SCALES

    EPA Science Inventory

    Ecological systems with hierarchical organization and non-equilibrium dynamics require multiple-scale analyses to comprehend how a system is structured and to formulate hypotheses about regulatory mechanisms. Characteristic scales in real landscapes are determined by, or at least...

  12. Coalescence-Induced Jumping of Multiple Condensate Droplets on Hierarchical Superhydrophobic Surfaces

    PubMed Central

    Chen, Xuemei; Patel, Ravi S.; Weibel, Justin A.; Garimella, Suresh V.

    2016-01-01

    Coalescence-induced jumping of condensate droplets from a superhydrophobic surface with hierarchical micro/nanoscale roughness is quantitatively characterized. Experimental observations show that the condensate droplet jumping is induced by coalescence of multiple droplets of different sizes, and that the coalesced droplet trajectories typically deviate from the surface normal. A depth-from-defocus image processing technique is developed to track the out-of-plane displacement of the jumping droplets, so as to accurately measure the droplet size and velocity. The results demonstrate that the highest jumping velocity is achieved when two droplets coalesce. The jumping velocity decreases gradually with an increase in the number of coalescing droplets, despite the greater potential surface energy released upon coalescence. A general theoretical model that accounts for viscous dissipation, surface adhesion, line tension, the initial droplet wetting states, and the number and sizes of the coalescing droplets is developed to explain the trends of droplet jumping velocity observed in the experiments. PMID:26725512

  13. Accelerated multiplicative updates and hierarchical ALS algorithms for nonnegative matrix factorization.

    PubMed

    Gillis, Nicolas; Glineur, François

    2012-04-01

    Nonnegative matrix factorization (NMF) is a data analysis technique used in a great variety of applications such as text mining, image processing, hyperspectral data analysis, computational biology, and clustering. In this letter, we consider two well-known algorithms designed to solve NMF problems: the multiplicative updates of Lee and Seung and the hierarchical alternating least squares of Cichocki et al. We propose a simple way to significantly accelerate these schemes, based on a careful analysis of the computational cost needed at each iteration, while preserving their convergence properties. This acceleration technique can also be applied to other algorithms, which we illustrate on the projected gradient method of Lin. The efficiency of the accelerated algorithms is empirically demonstrated on image and text data sets and compares favorably with a state-of-the-art alternating nonnegative least squares algorithm. PMID:22168561

  14. Combining information from multiple flood projections in a hierarchical Bayesian framework

    NASA Astrophysics Data System (ADS)

    Le Vine, Nataliya

    2016-04-01

    This study demonstrates, in the context of flood frequency analysis, the potential of a recently proposed hierarchical Bayesian approach to combine information from multiple models. The approach explicitly accommodates shared multimodel discrepancy as well as the probabilistic nature of the flood estimates, and treats the available models as a sample from a hypothetical complete (but unobserved) set of models. The methodology is applied to flood estimates from multiple hydrological projections (the Future Flows Hydrology data set) for 135 catchments in the UK. The advantages of the approach are shown to be: (1) to ensure adequate "baseline" with which to compare future changes; (2) to reduce flood estimate uncertainty; (3) to maximize use of statistical information in circumstances where multiple weak predictions individually lack power, but collectively provide meaningful information; (4) to diminish the importance of model consistency when model biases are large; and (5) to explicitly consider the influence of the (model performance) stationarity assumption. Moreover, the analysis indicates that reducing shared model discrepancy is the key to further reduction of uncertainty in the flood frequency analysis. The findings are of value regarding how conclusions about changing exposure to flooding are drawn, and to flood frequency change attribution studies.

  15. The Formation of Hierarchical Systems in Star Clusters

    NASA Astrophysics Data System (ADS)

    Aarseth, S. J.

    Results of star cluster simulations on HARP show that hierarchical systems play an important role for the overall dynamics. Models with 8000 single stars and 2000 primordial binaries reveal a gradual build-up and more than 20 such systems may exist during the later stages of evolution. We concentrate on the formation of hierarchies and their stability. This analysis is facilitated by the use of chain regularization which provides a natural tool for investigating the formation mechanism. Although hierarchies can be considered as newly formed binaries, their mode of formation often leads directly to hard binding energies. Most of these systems are formed by close two-body encounters between binaries, whereas standard binaries form by the classical three-body process and their appearance is therefore coinsiderably less pronounced. Finally, we discuss the implications of persistent higher-order systems for direct N-body simulations of globular clusters.

  16. Hierarchical Modeling and Robust Synthesis for the Preliminary Design of Large Scale Complex Systems

    NASA Technical Reports Server (NTRS)

    Koch, Patrick N.

    1997-01-01

    Large-scale complex systems are characterized by multiple interacting subsystems and the analysis of multiple disciplines. The design and development of such systems inevitably requires the resolution of multiple conflicting objectives. The size of complex systems, however, prohibits the development of comprehensive system models, and thus these systems must be partitioned into their constituent parts. Because simultaneous solution of individual subsystem models is often not manageable iteration is inevitable and often excessive. In this dissertation these issues are addressed through the development of a method for hierarchical robust preliminary design exploration to facilitate concurrent system and subsystem design exploration, for the concurrent generation of robust system and subsystem specifications for the preliminary design of multi-level, multi-objective, large-scale complex systems. This method is developed through the integration and expansion of current design techniques: Hierarchical partitioning and modeling techniques for partitioning large-scale complex systems into more tractable parts, and allowing integration of subproblems for system synthesis; Statistical experimentation and approximation techniques for increasing both the efficiency and the comprehensiveness of preliminary design exploration; and Noise modeling techniques for implementing robust preliminary design when approximate models are employed. Hierarchical partitioning and modeling techniques including intermediate responses, linking variables, and compatibility constraints are incorporated within a hierarchical compromise decision support problem formulation for synthesizing subproblem solutions for a partitioned system. Experimentation and approximation techniques are employed for concurrent investigations and modeling of partitioned subproblems. A modified composite experiment is introduced for fitting better predictive models across the ranges of the factors, and an approach for

  17. Secular motion in a hierarchic triple stellar system

    NASA Astrophysics Data System (ADS)

    Breiter, S.; Vokrouhlický, D.

    2015-05-01

    A system of equations is derived for the secular motion of a hierarchic triple stellar system. Mean anomalies of the inner binary system and of the outer star orbit are eliminated up to order 9 in the ratio of their Delaunay momenta. Thanks to the use of vectorial elements (angular momenta and Laplace vectors) the equations are non-singular, compact, and independent on the choice of the reference frame axes directions. In the limit of circular outer orbit, the secular Hamiltonian agrees with the forgotten solution by Brown. Being more complete, yet simpler, the present model differs from that of Krymolowski & Mazeh, except for the circular outer orbit limit. A simple extension of the secular equations of motion describing tidal friction is also provided.

  18. Hierarchical Regression for Multiple Comparisons in a Case-Control Study of Occupational Risks for Lung Cancer

    PubMed Central

    Corbin, Marine; Richiardi, Lorenzo; Vermeulen, Roel; Kromhout, Hans; Merletti, Franco; Peters, Susan; Simonato, Lorenzo; Steenland, Kyle; Pearce, Neil; Maule, Milena

    2012-01-01

    Background Occupational studies often involve multiple comparisons and therefore suffer from false positive findings. Semi-Bayes adjustment methods have sometimes been used to address this issue. Hierarchical regression is a more general approach, including Semi-Bayes adjustment as a special case, that aims at improving the validity of standard maximum-likelihood estimates in the presence of multiple comparisons by incorporating similarities between the exposures of interest in a second-stage model. Methodology/Principal Findings We re-analysed data from an occupational case-control study of lung cancer, applying hierarchical regression. In the second-stage model, we included the exposure to three known lung carcinogens (asbestos, chromium and silica) for each occupation, under the assumption that occupations entailing similar carcinogenic exposures are associated with similar risks of lung cancer. Hierarchical regression estimates had smaller confidence intervals than maximum-likelihood estimates. The shrinkage toward the null was stronger for extreme, less stable estimates (e.g., “specialised farmers”: maximum-likelihood OR: 3.44, 95%CI 0.90–13.17; hierarchical regression OR: 1.53, 95%CI 0.63–3.68). Unlike Semi-Bayes adjustment toward the global mean, hierarchical regression did not shrink all the ORs towards the null (e.g., “Metal smelting, converting and refining furnacemen”: maximum-likelihood OR: 1.07, Semi-Bayes OR: 1.06, hierarchical regression OR: 1.26). Conclusions/Significance Hierarchical regression could be a valuable tool in occupational studies in which disease risk is estimated for a large amount of occupations when we have information available on the key carcinogenic exposures involved in each occupation. With the constant progress in exposure assessment methods in occupational settings and the availability of Job Exposure Matrices, it should become easier to apply this approach. PMID:22701732

  19. A hierarchically distributed architecture for fault isolation expert systems on the space station

    NASA Technical Reports Server (NTRS)

    Miksell, Steve; Coffer, Sue

    1987-01-01

    The Space Station Axiomatic Fault Isolating Expert Systems (SAFTIES) system deals with the hierarchical distribution of control and knowledge among independent expert systems doing fault isolation and scheduling of Space Station subsystems. On its lower level, fault isolation is performed on individual subsystems. These fault isolation expert systems contain knowledge about the performance requirements of their particular subsystem and corrective procedures which may be involved in repsonse to certain performance errors. They can control the functions of equipment in their system and coordinate system task schedules. On a higher level, the Executive contains knowledge of all resources, task schedules for all systems, and the relative priority of all resources and tasks. The executive can override any subsystem task schedule in order to resolve use conflicts or resolve errors that require resources from multiple subsystems. Interprocessor communication is implemented using the SAFTIES Communications Interface (SCI). The SCI is an application layer protocol which supports the SAFTIES distributed multi-level architecture.

  20. Beyond the basics: preschool children label objects flexibly at multiple hierarchical levels.

    PubMed

    Waxman, S R; Hatch, T

    1992-02-01

    Although preschoolers typically accept the basic level label for an object (e.g. dog) and tend to resist all others (e.g. collie, animal), this tendency is not inviolable. Under certain circumstances, children accept more than one label per object. In this experiment, with 20 three- and 20 four-year-old children, we extended this body of research in three ways. We examined (I) children's production of multiple, hierarchically related labels; (2) the pragmatic consequences of the inherent asymmetry of inclusion relations; and (3) the influence of morphology (modifier+noun constructions vs. simple lexemes) at the subordinate level. Children labelled objects most frequently at the basic level, but also readily produced many non-basic level terms. Children, like adults, may prefer to label objects at the basic level, but they exhibit no general prohibition against also labelling at other, non-basic levels. Their performance challenges the notion that the ability to label objects flexibly at multiple levels is beyond the young child's capacity.

  1. Compiling software for a hierarchical distributed processing system

    DOEpatents

    Archer, Charles J; Blocksome, Michael A; Ratterman, Joseph D; Smith, Brian E

    2013-12-31

    Compiling software for a hierarchical distributed processing system including providing to one or more compiling nodes software to be compiled, wherein at least a portion of the software to be compiled is to be executed by one or more nodes; compiling, by the compiling node, the software; maintaining, by the compiling node, any compiled software to be executed on the compiling node; selecting, by the compiling node, one or more nodes in a next tier of the hierarchy of the distributed processing system in dependence upon whether any compiled software is for the selected node or the selected node's descendents; sending to the selected node only the compiled software to be executed by the selected node or selected node's descendent.

  2. A hierarchical distributed control model for coordinating intelligent systems

    NASA Technical Reports Server (NTRS)

    Adler, Richard M.

    1991-01-01

    A hierarchical distributed control (HDC) model for coordinating cooperative problem-solving among intelligent systems is described. The model was implemented using SOCIAL, an innovative object-oriented tool for integrating heterogeneous, distributed software systems. SOCIAL embeds applications in 'wrapper' objects called Agents, which supply predefined capabilities for distributed communication, control, data specification, and translation. The HDC model is realized in SOCIAL as a 'Manager'Agent that coordinates interactions among application Agents. The HDC Manager: indexes the capabilities of application Agents; routes request messages to suitable server Agents; and stores results in a commonly accessible 'Bulletin-Board'. This centralized control model is illustrated in a fault diagnosis application for launch operations support of the Space Shuttle fleet at NASA, Kennedy Space Center.

  3. Requirements for implementing real-time control functional modules on a hierarchical parallel pipelined system

    NASA Technical Reports Server (NTRS)

    Wheatley, Thomas E.; Michaloski, John L.; Lumia, Ronald

    1989-01-01

    Analysis of a robot control system leads to a broad range of processing requirements. One fundamental requirement of a robot control system is the necessity of a microcomputer system in order to provide sufficient processing capability.The use of multiple processors in a parallel architecture is beneficial for a number of reasons, including better cost performance, modular growth, increased reliability through replication, and flexibility for testing alternate control strategies via different partitioning. A survey of the progression from low level control synchronizing primitives to higher level communication tools is presented. The system communication and control mechanisms of existing robot control systems are compared to the hierarchical control model. The impact of this design methodology on the current robot control systems is explored.

  4. Dynamic Non-Hierarchical File Systems for Exascale Storage

    SciTech Connect

    Long, Darrell E.; Miller, Ethan L

    2015-02-24

    This constitutes the final report for “Dynamic Non-Hierarchical File Systems for Exascale Storage”. The ultimate goal of this project was to improve data management in scientific computing and high-end computing (HEC) applications, and to achieve this goal we proposed: to develop the first, HEC-targeted, file system featuring rich metadata and provenance collection, extreme scalability, and future storage hardware integration as core design goals, and to evaluate and develop a flexible non-hierarchical file system interface suitable for providing more powerful and intuitive data management interfaces to HEC and scientific computing users. Data management is swiftly becoming a serious problem in the scientific community – while copious amounts of data are good for obtaining results, finding the right data is often daunting and sometimes impossible. Scientists participating in a Department of Energy workshop noted that most of their time was spent “...finding, processing, organizing, and moving data and it’s going to get much worse”. Scientists should not be forced to become data mining experts in order to retrieve the data they want, nor should they be expected to remember the naming convention they used several years ago for a set of experiments they now wish to revisit. Ideally, locating the data you need would be as easy as browsing the web. Unfortunately, existing data management approaches are usually based on hierarchical naming, a 40 year-old technology designed to manage thousands of files, not exabytes of data. Today’s systems do not take advantage of the rich array of metadata that current high-end computing (HEC) file systems can gather, including content-based metadata and provenance1 information. As a result, current metadata search approaches are typically ad hoc and often work by providing a parallel management system to the “main” file system, as is done in Linux (the locate utility), personal computers, and enterprise search

  5. Secular Orbital Dynamics of Hierarchical Two-planet Systems

    NASA Astrophysics Data System (ADS)

    Veras, Dimitri; Ford, Eric B.

    2010-06-01

    The discovery of multi-planet extrasolar systems has kindled interest in using their orbital evolution as a probe of planet formation. Accurate descriptions of planetary orbits identify systems that could hide additional planets or be in a special dynamical state, and inform targeted follow-up observations. We combine published radial velocity data with Markov Chain Monte Carlo analyses in order to obtain an ensemble of masses, semimajor axes, eccentricities, and orbital angles for each of the five dynamically active multi-planet systems: HD 11964, HD 38529, HD 108874, HD 168443, and HD 190360. We dynamically evolve these systems using 52,000 long-term N-body integrations that sample the full range of possible line-of-sight and relative inclinations, and we report on the system stability, secular evolution, and the extent of the resonant interactions. We find that planetary orbits in hierarchical systems exhibit complex dynamics and can become highly eccentric and maybe significantly inclined. Additionally, we incorporate the effects of general relativity in the long-term simulations and demonstrate that it can qualitatively affect the dynamics of some systems with high relative inclinations. The simulations quantify the likelihood of different dynamical regimes for each system and highlight the dangers of restricting simulation phase space to a single set of initial conditions or coplanar orbits.

  6. A Hierarchical Statistic Methodology for Advanced Memory System Evaluation

    SciTech Connect

    Sun, X.-J.; He, D.; Cameron, K.W.; Luo, Y.

    1999-04-12

    Advances in technology have resulted in a widening of the gap between computing speed and memory access time. Data access time has become increasingly important for computer system design. Various hierarchical memory architectures have been developed. The performance of these advanced memory systems, however, varies with applications and problem sizes. How to reach an optimal cost/performance design eludes researchers still. In this study, the authors introduce an evaluation methodology for advanced memory systems. This methodology is based on statistical factorial analysis and performance scalability analysis. It is two fold: it first determines the impact of memory systems and application programs toward overall performance; it also identifies the bottleneck in a memory hierarchy and provides cost/performance comparisons via scalability analysis. Different memory systems can be compared in terms of mean performance or scalability over a range of codes and problem sizes. Experimental testing has been performed extensively on the Department of Energy's Accelerated Strategic Computing Initiative (ASCI) machines and benchmarks available at the Los Alamos National Laboratory to validate this newly proposed methodology. Experimental and analytical results show this methodology is simple and effective. It is a practical tool for memory system evaluation and design. Its extension to general architectural evaluation and parallel computer systems are possible and should be further explored.

  7. Automated control of hierarchical systems using value-driven methods

    NASA Technical Reports Server (NTRS)

    Pugh, George E.; Burke, Thomas E.

    1990-01-01

    An introduction is given to the Value-driven methodology, which has been successfully applied to solve a variety of difficult decision, control, and optimization problems. Many real-world decision processes (e.g., those encountered in scheduling, allocation, and command and control) involve a hierarchy of complex planning considerations. For such problems it is virtually impossible to define a fixed set of rules that will operate satisfactorily over the full range of probable contingencies. Decision Science Applications' value-driven methodology offers a systematic way of automating the intuitive, common-sense approach used by human planners. The inherent responsiveness of value-driven systems to user-controlled priorities makes them particularly suitable for semi-automated applications in which the user must remain in command of the systems operation. Three examples of the practical application of the approach in the automation of hierarchical decision processes are discussed: the TAC Brawler air-to-air combat simulation is a four-level computerized hierarchy; the autonomous underwater vehicle mission planning system is a three-level control system; and the Space Station Freedom electrical power control and scheduling system is designed as a two-level hierarchy. The methodology is compared with rule-based systems and with other more widely-known optimization techniques.

  8. Hierarchical brain tissue segmentation and its application in multiple sclerosis and Alzheimer's disease

    NASA Astrophysics Data System (ADS)

    Lei, Tianhu; Udupa, Jayaram K.; Moonis, Gul; Schwartz, Eric; Balcer, Laura

    2005-04-01

    Based on Fuzzy Connectedness (FC) object delineation principles and algorithms, a hierarchical brain tissue segmentation technique has been developed for MR images. After MR image background intensity inhomogeneity correction and intensity standardization, three FC objects for cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) are generated via FC object delineation, and an intracranial (IC) mask is created via morphological operations. Then, the IC mask is decomposed into parenchymal (BP) and CSF masks, while the BP mask is separated into WM and GM masks. WM mask is further divided into pure and dirty white matter masks (PWM and DWM). In Multiple Sclerosis studies, a severe white matter lesion (LS) mask is defined from DWM mask. Based on the segmented brain tissue images, a histogram-based method has been developed to find disease-specific, image-based quantitative markers for characterizing the macromolecular manifestation of the two diseases. These same procedures have been applied to 65 MS (46 patients and 19 normal subjects) and 25 AD (15 patients and 10 normal subjects) data sets, each of which consists of FSE PD- and T2-weighted MR images. Histograms representing standardized PD and T2 intensity distributions and their numerical parameters provide an effective means for characterizing the two diseases. The procedures are systematic, nearly automated, robust, and the results are reproducible.

  9. The Stability and Fates of Hierarchical Two-planet Systems

    NASA Astrophysics Data System (ADS)

    Petrovich, Cristobal

    2015-08-01

    We study the dynamical stability and fates of hierarchical (in semimajor axis) two-planet systems with arbitrary eccentricities and mutual inclinations. We run a large number of long-term numerical integrations and use the Support Vector Machine algorithm to search for an empirical boundary that best separates stable systems from systems experiencing either ejections or collisions with the star. We propose the following new criterion for dynamical stability: {a}{out}(1-{e}{out}){/[a}{in} (1+{e}{in})]\\gt 2.4 {≤ft[{max}({μ }{in},{μ }{out})\\right]}1/3 {({a}{out}{/a}{in})}1/2+1.15, which should be applicable to planet-star mass ratios {μ }{in},{μ }{out}={10}-4-{10}-2, integration times up to 108 orbits of the inner planet, and mutual inclinations ≲ 40^\\circ . Systems that do not satisfy this condition by a margin of ≳ 0.5 are expected to be unstable, mostly leading to planet ejections if {μ }{in}\\gt {μ }{out}, while slightly favoring collisions with the star for {μ }{in}\\lt {μ }{out}. We use our numerical integrations to test other stability criteria that have been proposed in the literature and show that our stability criterion performs significantly better for the range of system parameters that we have explored.

  10. HiCoDG: A Hierarchical Data-Gathering Scheme Using Cooperative Multiple Mobile Elements †

    PubMed Central

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-01-01

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption. PMID:25526356

  11. HiCoDG: a hierarchical data-gathering scheme using cooperative multiple mobile elements.

    PubMed

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-12-17

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption.

  12. Multiple system atrophy.

    PubMed

    Peeraully, Tasneem

    2014-04-01

    Multiple system atrophy (MSA) is a rare adult-onset synucleinopathy associated with dysautonomia and the variable presence of poorly levodopa-responsive parkinsonism and/or cerebellar ataxia. Other clinical symptoms that can be associated with MSA include hyperreflexia, stridor, sleep apnea, and rapid eye movement sleep behavior disorder (RBD). Mean survival from time of diagnosis ranges between 6 to 10 years, and definitive diagnosis is made on autopsy with demonstration of oligodendroglial cytoplasmic inclusions consisting of fibrillar α-synuclein. Magnetic resonance imaging (MRI) may be positive for cruciform T2 hyperintensity within the pons (the "hot cross bun sign"), volume loss in the pons and cerebellum, and T2 signal loss in the dorsolateral putamen with hyperintense rim on fluid attenuated inversion recovery (FLAIR) sequencing. Although most cases are sporadic, genetic polymorphisms have been identified both in familial and sporadic cases of MSA, and influence observed phenotypes. Treatment is symptomatic, with both pharmacological and nonpharmacological strategies. There are currently no consensus guidelines on management. Current and future research is aimed at identifying biomarkers and developing disease-modifying therapies.

  13. Photodynamical modeling of hierarchical stellar system KOI-126

    NASA Astrophysics Data System (ADS)

    Earl, Nicholas Michael

    The power and precision of the Kepler space telescope has provided the astrophysical field with a valuable insight into the dynamics of extra-solar systems. KOI-126 represents the first eclipsing hierarchical triple stellar system identified in the Kepler mission's photometry. The dynamics of the system are such that ascertaining the parameters of each body accurately (better than a few percent) is possible from the photometry alone. This allows determination of the characteristics while avoiding biases inherent in traditional studies of low-mass eclipsing systems. The parameter set for KOI-126 was originally reported on by Carter et al. and is uniquely composed of a low-mass binary, KOI-126 B and KOI-126 C. This pair orbits a third, more massive star KOI-126 A. The original analysis employed a full dynamical-photometric model, utilizing a Levenberg-Marquardt algorithm and least-squares minimization, to fit the short-cadence (i.e. successive 58.84 second cadence exposures) photometric data from the Kepler spacecraft captured over a period of 247 days. The updated catalog of short-cadence data now covers a span of 1,300 days. In light of the new data, and the valuable contribution accurately sampled fully-convective stars offer to theoretical stellar models, it is therefore relevant to refine the parameters of this system. Furthermore, with the ubiquity of multi-stellar systems, a well documented, portable, scalable computer modeling code for N-body systems is introduced. Thus, a new analysis is done on KOI-126 using this parallelized dynamical-photometric modeling package written in Python, based on Carter et al.'s original code, titled Pynamic. Pynamic allows the use of several fitting algorithms, but in this analysis utilizes the affine-invariant Markov chain Monte Carlo ensemble.

  14. Tensegrity I. Cell structure and hierarchical systems biology

    NASA Technical Reports Server (NTRS)

    Ingber, Donald E.

    2003-01-01

    In 1993, a Commentary in this journal described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (J. Cell Sci. 104, 613-627). The cellular tensegrity model can now be revisited and placed in context of new advances in our understanding of cell structure, biological networks and mechanoregulation that have been made over the past decade. Recent work provides strong evidence to support the use of tensegrity by cells, and mathematical formulations of the model predict many aspects of cell behavior. In addition, development of the tensegrity theory and its translation into mathematical terms are beginning to allow us to define the relationship between mechanics and biochemistry at the molecular level and to attack the larger problem of biological complexity. Part I of this two-part article covers the evidence for cellular tensegrity at the molecular level and describes how this building system may provide a structural basis for the hierarchical organization of living systems--from molecule to organism. Part II, which focuses on how these structural networks influence information processing networks, appears in the next issue.

  15. A hierarchical stochastic model of large-scale atmospheric circulation patterns and multiple station daily precipitation

    NASA Astrophysics Data System (ADS)

    Wilson, Larry L.; Lettenmaier, Dennis P.; Skyllingstad, Eric

    1992-02-01

    A stochastic model of weather states and concurrent daily precipitation at multiple precipitation stations is described. Four algorithms are investigated for classification of daily weather states: k-means clustering, fuzzy clustering, principal components, and principal components coupled with k-means clustering. A semi-Markov model with a geometric distribution for within-class lengths of stay is used to describe the evolution of weather classes. A hierarchical modified Pólya urn model is used to simulate precipitation conditioned on the regional weather type. An information measure that considers both the probability of weather class occurrence and conditional precipitation probabilities is developed to quantify the extent to which each of the weather classification schemes discriminates the precipitation states (rain-no rain) at the precipitation stations. Evaluation of the four algorithms using the information measure shows that all methods performed equally well. The principal components method is chosen due to its ability to incorporate information from larger spatial fields. Precipitation amount distributions are assumed to be drawn from spatially correlated mixed exponential distributions, whose parameters varied by season and weather class. The model is implemented using National Meteorological Center historical atmospheric observations for the period 1964-1988 mapped to 5° × 5° grid cells over the eastern North Pacific, and three precipitation stations west of the Cascade mountain range in the state of Washington. Comparison of simulated weather class-station precipitation time series with observational data shows that the model preserved weather class statistics and mean daily precipitation quite well, especially for stations highest in the hierarchy. Precipitation amounts for the lowest precipitation station in the hierarchy, and for precipitation extremes, are not as well preserved.

  16. Hierarchical and Parallelizable Direct Volume Rendering for Irregular and Multiple Grids

    NASA Technical Reports Server (NTRS)

    Wilhelms, Jane; VanGelder, Allen; Tarantino, Paul; Gibbs, Jonathan

    1996-01-01

    A general volume rendering technique is described that efficiently produces images of excellent quality from data defined over irregular grids having a wide variety of formats. Rendering is done in software, eliminating the need for special graphics hardware, as well as any artifacts associated with graphics hardware. Images of volumes with about one million cells can be produced in one to several minutes on a workstation with a 150 MHz processor. A significant advantage of this method for applications such as computational fluid dynamics is that it can process multiple intersecting grids. Such grids present problems for most current volume rendering techniques. Also, the wide range of cell sizes (by a factor of 10,000 or more), which is typical of such applications, does not present difficulties, as it does for many techniques. A spatial hierarchical organization makes it possible to access data from a restricted region efficiently. The tree has greater depth in regions of greater detail, determined by the number of cells in the region. It also makes it possible to render useful 'preview' images very quickly (about one second for one-million-cell grids) by displaying each region associated with a tree node as one cell. Previews show enough detail to navigate effectively in very large data sets. The algorithmic techniques include use of a kappa-d tree, with prefix-order partitioning of triangles, to reduce the number of primitives that must be processed for one rendering, coarse-grain parallelism for a shared-memory MIMD architecture, a new perspective transformation that achieves greater numerical accuracy, and a scanline algorithm with depth sorting and a new clipping technique.

  17. Predictability of extremes in non-linear hierarchically organized systems

    NASA Astrophysics Data System (ADS)

    Kossobokov, V. G.; Soloviev, A.

    2011-12-01

    Understanding the complexity of non-linear dynamics of hierarchically organized systems progresses to new approaches in assessing hazard and risk of the extreme catastrophic events. In particular, a series of interrelated step-by-step studies of seismic process along with its non-stationary though self-organized behaviors, has led already to reproducible intermediate-term middle-range earthquake forecast/prediction technique that has passed control in forward real-time applications during the last two decades. The observed seismic dynamics prior to and after many mega, great, major, and strong earthquakes demonstrate common features of predictability and diverse behavior in course durable phase transitions in complex hierarchical non-linear system of blocks-and-faults of the Earth lithosphere. The confirmed fractal nature of earthquakes and their distribution in space and time implies that many traditional estimations of seismic hazard (from term-less to short-term ones) are usually based on erroneous assumptions of easy tractable analytical models, which leads to widespread practice of their deceptive application. The consequences of underestimation of seismic hazard propagate non-linearly into inflicted underestimation of risk and, eventually, into unexpected societal losses due to earthquakes and associated phenomena (i.e., collapse of buildings, landslides, tsunamis, liquefaction, etc.). The studies aimed at forecast/prediction of extreme events (interpreted as critical transitions) in geophysical and socio-economical systems include: (i) large earthquakes in geophysical systems of the lithosphere blocks-and-faults, (ii) starts and ends of economic recessions, (iii) episodes of a sharp increase in the unemployment rate, (iv) surge of the homicides in socio-economic systems. These studies are based on a heuristic search of phenomena preceding critical transitions and application of methodologies of pattern recognition of infrequent events. Any study of rare

  18. Hierarchical pore structure of calcium phosphate scaffolds by a combination of gel-casting and multiple tape-casting methods.

    PubMed

    Sánchez-Salcedo, S; Werner, J; Vallet-Regí, M

    2008-07-01

    The objective of this work was to design hierarchical pore structure scaffolds with potential applications in bone tissue regeneration. For that purpose, a bioceramic material such as biphasic calcium phosphate, which consists of a mixture of hydroxyapatite and beta-tricalcium phosphate, was selected. Multilayer pieces (MLP) with hierarchical pore structure were developed employing a new technique that combines gel casting and adding porogens, using multiple tape-casting methods. Pieces with functionally graded porosity were fabricated using porogens with different sizes. The porogens used were Porlat K85 and Porlat K86 with diameters <150 microm and 150-300 microm, respectively. Two types of sintered tapes, with different porosity, no cracking and enough interconnection size were selected. MLP with hierarchical pore structure were designed by the multiple tape-casting method. Interconnected pores whose sizes increase from interior tapes (1.6-3.6 microm) towards exterior tapes (20-51.5 microm) and interpenetration between tapes were achieved. Delamination or cracking were not observed after heat treatment. The flexural strength of pieces was investigated by the three-point bending test. This new combination of methods offers the possibility of manufacturing scaffolds with interconnected pore sizes ranging from 1.6 to 51.5 microm.

  19. Incorporating Usability Criteria into the Development of Animated Hierarchical Maps

    ERIC Educational Resources Information Center

    Shih, Yu-Cheng; Huang, Pei-Ren; Chen, Sherry Y.

    2013-01-01

    Nowadays, Web-based learning systems have become popular because they can provide multiple tools, among which hierarchical maps are widely used to support teaching and learning. However, traditional hierarchical maps may let learners easily get lost within large information space. This study proposes an animated hierarchical map to address this…

  20. Hierarchical Self-Assembly of Peptide Amphiphiles: Form and Function at Multiple Length Scales

    NASA Astrophysics Data System (ADS)

    Zha, Runye Helen

    Hierarchical self-assembly, the organization of molecules into supramolecular structures of increasing size and complexity, is a potent tool for materials synthesis and requires understanding the connections of structure across multiple length scales. Herein, self-assembly of peptide amphiphiles (PAs) into nanoscopic and macroscopic materials is explored, and their anti-cancer applications are investigated. First, nanoscale assembly is examined in the context of an anti-angiogenic PA bearing the G-helix motif of maspin, a tumor suppressor protein. Assembly of this maspin-mimetic PA (MMPA) stabilizes the native G-helix conformation and improves binding to endothelial cells. Furthermore, PA nanostructures significantly increase cell adhesion to fibronectin as compared to G-helix peptide alone. Combined with its inhibitory effect on cell migration, MMPA nanostructures thus show anti-angiogenic activity on par with maspin protein in vitro and in vivo. Second, assembly of cationic PAs with hyaluronic acid (HA), an anionic polyelectrolyte, into macroscopic membranes is explored using PAs with identical formal charge but systematically varied self-assembly domains. Results suggest that membrane formation is dictated by the initial moments of component aggregation and is highly sensitive to PA molecular structure via nanoscale assembly. Specifically, PAs with beta-sheet forming residues are nanofibrous and have high surface charge density, leading to robust membranes with aligned-fiber microstructure. PAs without beta-sheet forming residues are nanospherical and have low surface charge density, leading to weak membranes with non-fibrous finger-like microstructure. Lastly, the principles of PA-HA membrane assembly are applied towards development of anti-cancer therapeutic biomaterials. Here, cytotoxic PAs bearing the epitope (KLAKLAKbeta)2 are co-assembled with non-bioactive cationic PA in order to achieve varying nanoscale morphology. These nanostructures are then

  1. Kepler's Multiple Planet Systems

    NASA Technical Reports Server (NTRS)

    Lissauer, Jack J.

    2012-01-01

    Among the 1800 Kepler targets that have candidate planets, 20% have two or more candidate planets. While most of these objects have not yet been confirmed as true planets, several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Virtually all candidate systems are stable, as tested by numerical integrations (assuming a nominal mass-radius relationship). Statistical studies performed on these candidates reveal a great deal about the architecture of planetary systems, including the typical spacing of orbits and flatness of planetary systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. The characteristics of the confirmed Kepler multi-planet systems will also be discussed.

  2. Hierarchical fractal Weyl laws for chaotic resonance states in open mixed systems.

    PubMed

    Körber, M J; Michler, M; Bäcker, A; Ketzmerick, R

    2013-09-13

    In open chaotic systems the number of long-lived resonance states obeys a fractal Weyl law, which depends on the fractal dimension of the chaotic saddle. We study the generic case of a mixed phase space with regular and chaotic dynamics. We find a hierarchy of fractal Weyl laws, one for each region of the hierarchical decomposition of the chaotic phase-space component. This is based on our observation of hierarchical resonance states localizing on these regions. Numerically this is verified for the standard map and a hierarchical model system.

  3. Multiple system atrophy

    MedlinePlus

    ... nervous system that controls important functions such as heart rate, blood pressure, and sweating. ... A pacemaker that is programmed to stimulate the heart to beat at a rapid rate (faster than 100 beats per minute) may increase ...

  4. Hierarchical Multiple Regression in Counseling Research: Common Problems and Possible Remedies.

    ERIC Educational Resources Information Center

    Petrocelli, John V.

    2003-01-01

    A brief content analysis was conducted on the use of hierarchical regression in counseling research published in the "Journal of Counseling Psychology" and the "Journal of Counseling & Development" during the years 1997-2001. Common problems are cited and possible remedies are described. (Contains 43 references and 3 tables.) (Author)

  5. Bottom-up GGM algorithm for constructing multiple layered hierarchical gene regulatory networks

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Multilayered hierarchical gene regulatory networks (ML-hGRNs) are very important for understanding genetics regulation of biological pathways. However, there are currently no computational algorithms available for directly building ML-hGRNs that regulate biological pathways. A bottom-up graphic Gaus...

  6. Optimizing Blocking and Nonblocking Reduction Operations for Multicore Systems: Hierarchical Design and Implementation

    SciTech Connect

    Gorentla Venkata, Manjunath; Shamis, Pavel; Graham, Richard L; Ladd, Joshua S; Sampath, Rahul S

    2013-01-01

    Many scientific simulations, using the Message Passing Interface (MPI) programming model, are sensitive to the performance and scalability of reduction collective operations such as MPI Allreduce and MPI Reduce. These operations are the most widely used abstractions to perform mathematical operations over all processes that are part of the simulation. In this work, we propose a hierarchical design to implement the reduction operations on multicore systems. This design aims to improve the efficiency of reductions by 1) tailoring the algorithms and customizing the implementations for various communication mechanisms in the system 2) providing the ability to configure the depth of hierarchy to match the system architecture, and 3) providing the ability to independently progress each of this hierarchy. Using this design, we implement MPI Allreduce and MPI Reduce operations (and its nonblocking variants MPI Iallreduce and MPI Ireduce) for all message sizes, and evaluate on multiple architectures including InfiniBand and Cray XT5. We leverage and enhance our existing infrastructure, Cheetah, which is a framework for implementing hierarchical collective operations to implement these reductions. The experimental results show that the Cheetah reduction operations outperform the production-grade MPI implementations such as Open MPI default, Cray MPI, and MVAPICH2, demonstrating its efficiency, flexibility and portability. On Infini- Band systems, with a microbenchmark, a 512-process Cheetah nonblocking Allreduce and Reduce achieves a speedup of 23x and 10x, respectively, compared to the default Open MPI reductions. The blocking variants of the reduction operations also show similar performance benefits. A 512-process nonblocking Cheetah Allreduce achieves a speedup of 3x, compared to the default MVAPICH2 Allreduce implementation. On a Cray XT5 system, a 6144-process Cheetah Allreduce outperforms the Cray MPI by 145%. The evaluation with an application kernel, Conjugate

  7. Some physical applications of random hierarchical matrices

    SciTech Connect

    Avetisov, V. A.; Bikulov, A. Kh.; Vasilyev, O. A.; Nechaev, S. K.; Chertovich, A. V.

    2009-09-15

    The investigation of spectral properties of random block-hierarchical matrices as applied to dynamic and structural characteristics of complex hierarchical systems with disorder is proposed for the first time. Peculiarities of dynamics on random ultrametric energy landscapes are discussed and the statistical properties of scale-free and polyscale (depending on the topological characteristics under investigation) random hierarchical networks (graphs) obtained by multiple mapping are considered.

  8. The Case for A Hierarchal System Model for Linux Clusters

    SciTech Connect

    Seager, M; Gorda, B

    2009-06-05

    The computer industry today is no longer driven, as it was in the 40s, 50s and 60s, by High-performance computing requirements. Rather, HPC systems, especially Leadership class systems, sit on top of a pyramid investment mode. Figure 1 shows a representative pyramid investment model for systems hardware. At the base of the pyramid is the huge investment (order 10s of Billions of US Dollars per year) in semiconductor fabrication and process technologies. These costs, which are approximately doubling with every generation, are funded from investments multiple markets: enterprise, desktops, games, embedded and specialized devices. Over and above these base technology investments are investments for critical technology elements such as microprocessor, chipsets and memory ASIC components. Investments for these components are spread across the same markets as the base semiconductor processes investments. These second tier investments are approximately half the size of the lower level of the pyramid. The next technology investment layer up, tier 3, is more focused on scalable computing systems such as those needed for HPC and other markets. These tier 3 technology elements include networking (SAN, WAN and LAN), interconnects and large scalable SMP designs. Above these is tier 4 are relatively small investments necessary to build very large, scalable systems high-end or Leadership class systems. Primary among these are the specialized network designs of vertically integrated systems, etc.

  9. Hierarchical flight control system synthesis for rotorcraft-based unmanned aerial vehicles

    NASA Astrophysics Data System (ADS)

    Shim, Hyunchul

    The Berkeley Unmanned Aerial Vehicle (UAV) research aims to design, implement, and analyze a group of autonomous intelligent UAVs and UGVs (Unmanned Ground Vehicles). The goal of this dissertation is to provide a comprehensive procedural methodology to design, implement, and test rotorcraft-based unmanned aerial vehicles (RUAVs). We choose the rotorcraft as the base platform for our aerial agents because it offers ideal maneuverability for our target scenarios such as the pursuit-evasion game. Aided by many enabling technologies such as lightweight and powerful computers, high-accuracy navigation sensors and communication devices, it is now possible to construct RUAVs capable of precise navigation and intelligent behavior by the decentralized onboard control system. Building a fully functioning RUAV requires a deep understanding of aeronautics, control theory and computer science as well as a tremendous effort for implementation. These two aspects are often inseparable and therefore equally highlighted throughout this research. The problem of multiple vehicle coordination is approached through the notion of a hierarchical system. The idea behind the proposed architecture is to build a hierarchical multiple-layer system that gradually decomposes the abstract mission objectives into the physical quantities of control input. Each RUAV incorporated into this system performs the given tasks and reports the results through the hierarchical communication channel back to the higher-level coordinator. In our research, we provide a theoretical and practical approach to build a number of RUAVs based on commercially available navigation sensors, computer systems, and radio-controlled helicopters. For the controller design, the dynamic model of the helicopter is first built. The helicopter exhibits a very complicated multi-input multi-output, nonlinear, time-varying and coupled dynamics, which is exposed to severe exogenous disturbances. This poses considerable difficulties for

  10. Entity grammar systems: a grammatical tool for studying the hierarchical structures of biological systems.

    PubMed

    Wang, Yun

    2004-05-01

    The hierarchical structures of biological systems are the typical complex hierarchical dynamical structures in the physical world, the effective investigations on which could not be performed with the existing formal grammar systems. To meet the needs of the investigation on these kinds of systems, especially the emerging field of system biology, a grammatical tool was proposed in the present article. Because the grammatical tool mainly deals with the systems composed of structured entities, they are called entity grammar systems (EGSs). The structure of entities in EGSs have the general form of the objects in the physical world, which means EGSs could be used as a tool to study the complex system composed of many objects with different structures, just like the biological systems. The article contains the formal definition of EGSs and the hierarchy of EGSs, which is congruent with the Chomsky hierarchy. The relationship between EGSs and array grammar systems, graph grammar systems, tree grammar systems, multi-set grammar systems are discussed to show the generative power of EGSs. At the end of the present article, the steps to define new grammar systems with the form of EGS are provided and the possible applicable fields of EGSs are discussed. PMID:15006443

  11. MAD (Multi-Agent-Delivery) Nanolayer: Delivering Multiple Therapeutics from Hierarchical Assembled Surface Coatings

    PubMed Central

    Kim, Byeong-Su; Smith, Renée C.; Poon, Zhiyong; Hammond, Paula T.

    2014-01-01

    We present the hydrolytically degradable polymeric multilayer films that can co-deliver multiple therapeutics of differing chemical characteristics (charged biomacromolecules and neutral hydrophobic small molecules) from a surface. This multi-agent-delivery (MAD) nanolayer system integrates the hydrolytically degradable poly(β-amino ester) as a structural component to control the degradation of the multilayers to release active therapeutic macromolecules, as well as hydrophobic drugs imbedded within amphiphilic block copolymer micellar carriers within layer-by-layer (LbL) films, which would otherwise be difficult to include within the multilayers. By varying the anionic therapeutic agents (heparin and dextran sulfate) within the multilayer, we examine how different structural components can be used to control the release kinetics of multiple therapeutics from MAD nanolayers. Controlled release profiles and the in vitro efficacy of the MAD nanolayers in suppressing the growth of human smooth muscle cell lines were evaluated. The dual delivery of a charged macromolecular heparin and a small hydrophobic drug, paclitaxel, is found to be synergistic and beneficial toward effective therapeutic activity. Furthermore, we compared the classical dipping method we employed here with an automated spray-LbL technique. Spray-LbL significantly facilitates film processing time while preserving the characteristic release profiles of the MAD nanolayers. With the highly versatile and tunable nature of LbL assembly, we anticipate that MAD nanolayers can provide a unique platform for delivering multiple therapeutics from macromolecular to small molecules with distinct release profiles for applications in biological and biomedical surface coatings. PMID:19630389

  12. Typical motions in multiple systems

    NASA Technical Reports Server (NTRS)

    Anosova, Joanna P.

    1990-01-01

    In very old times, people counted - one, two, many. The author wants to show that they were right. Consider the motions of isolated bodies: (1) N = 1 - simple motion; (2) N = 2 - Keplerian orbits; and (3) N = 3 - this is the difficult problem. In general, this problem can be studied only by computer simulations. The author studied this problem over many years (see, e.g., Agekian and Anosova, 1967; Anosova, 1986, 1989 a,b). The principal result is that two basic types of dynamics take place in triple systems. The first special type is the stable hierarchical systems with two almost Keplerian orbits. The second general type is the unstable triple systems with complicated motions of the bodies. By random choice of the initial conditions, by the Monte-Carlo method, the stable systems comprised about approx. 10% of the examined cases; the unstable systems comprised the other approx. 90% of cases under consideration. In N greater than 3, the studies of dynamics of such systems by computer simulations show that we have in general also the motions roughly as at the cases 1 - 3 with the relative negative or positive energies of the bodies. In the author's picture, the typical trajectories of the bodies in unstable triple systems of the general type of dynamics are seen. Such systems are disrupted always after close triple approaches of the bodies. These approaches play a role like the gravitational slingshot. Often, the velocities of escapers are very large. On the other hand, the movie also shows the dynamical processes of a formation, dynamical evolution and disruption of the temporary wide binaries in triples and a formation of final hard massive binaries in the final evolution of triples.

  13. EMIR: a configurable hierarchical system for event monitoring and incident response

    NASA Astrophysics Data System (ADS)

    Deich, William T. S.

    2014-07-01

    The Event Monitor and Incident Response system (emir) is a flexible, general-purpose system for monitoring and responding to all aspects of instrument, telescope, and general facility operations, and has been in use at the Automated Planet Finder telescope for two years. Responses to problems can include both passive actions (e.g. generating alerts) and active actions (e.g. modifying system settings). Emir includes a monitor-and-response daemon, plus graphical user interfaces and text-based clients that automatically configure themselves from data supplied at runtime by the daemon. The daemon is driven by a configuration file that describes each condition to be monitored, the actions to take when the condition is triggered, and how the conditions are aggregated into hierarchical groups of conditions. Emir has been implemented for the Keck Task Library (KTL) keyword-based systems used at Keck and Lick Observatories, but can be readily adapted to many event-driven architectures. This paper discusses the design and implementation of Emir , and the challenges in balancing the competing demands for simplicity, flexibility, power, and extensibility. Emir 's design lends itself well to multiple purposes, and in addition to its core monitor and response functions, it provides an effective framework for computing running statistics, aggregate values, and summary state values from the primitive state data generated by other subsystems, and even for creating quick-and-dirty control loops for simple systems.

  14. Self-assembled hierarchically structured organic-inorganic composite systems.

    PubMed

    Tritschler, Ulrich; Cölfen, Helmut

    2016-06-01

    Designing bio-inspired, multifunctional organic-inorganic composite materials is one of the most popular current research objectives. Due to the high complexity of biocomposite structures found in nacre and bone, for example, a one-pot scalable and versatile synthesis approach addressing structural key features of biominerals and affording bio-inspired, multifunctional organic-inorganic composites with advanced physical properties is highly challenging. This article reviews recent progress in synthesizing organic-inorganic composite materials via various self-assembly techniques and in this context highlights a recently developed bio-inspired synthesis concept for the fabrication of hierarchically structured, organic-inorganic composite materials. This one-step self-organization concept based on simultaneous liquid crystal formation of anisotropic inorganic nanoparticles and a functional liquid crystalline polymer turned out to be simple, fast, scalable and versatile, leading to various (multi-)functional composite materials, which exhibit hierarchical structuring over several length scales. Consequently, this synthesis approach is relevant for further progress and scientific breakthrough in the research field of bio-inspired and biomimetic materials. PMID:27175790

  15. Design, fabrication and testing of hierarchical micro-optical structures and systems

    NASA Astrophysics Data System (ADS)

    Cannistra, Aaron Thomas

    Micro-optical systems are becoming essential components in imaging, sensing, communications, computing, and other applications. Optically based designs are replacing electronic, chemical and mechanical systems for a variety of reasons, including low power consumption, reduced maintenance, and faster operation. However, as the number and variety of applications increases, micro-optical system designs are becoming smaller, more integrated, and more complicated. Micro and nano-optical systems found in nature, such as the imaging systems found in many insects and crustaceans, can have highly integrated optical structures that vary in size by orders of magnitude. These systems incorporate components such as compound lenses, anti-reflective lens surface structuring, spectral filters, and polarization selective elements. For animals, these hybrid optical systems capable of many optical functions in a compact package have been repeatedly selected during the evolutionary process. Understanding the advantages of these designs gives motivation for synthetic optical systems with comparable functionality. However, alternative fabrication methods that deviate from conventional processes are needed to create such systems. Further complicating the issue, the resulting device geometry may not be readily compatible with existing measurement techniques. This dissertation explores several nontraditional fabrication techniques for optical components with hierarchical geometries and measurement techniques to evaluate performance of such components. A micro-transfer molding process is found to produce high-fidelity micro-optical structures and is used to fabricate a spectral filter on a curved surface. By using a custom measurement setup we demonstrate that the spectral filter retains functionality despite the nontraditional geometry. A compound lens is fabricated using similar fabrication techniques and the imaging performance is analyzed. A spray coating technique for photoresist

  16. Multiple pass laser amplifier system

    DOEpatents

    Brueckner, Keith A.; Jorna, Siebe; Moncur, N. Kent

    1977-01-01

    A laser amplification method for increasing the energy extraction efficiency from laser amplifiers while reducing the energy flux that passes through a flux limited system which includes apparatus for decomposing a linearly polarized light beam into multiple components, passing the components through an amplifier in delayed time sequence and recombining the amplified components into an in phase linearly polarized beam.

  17. Multiple scales of patchiness and patch structure: a hierarchical framework for the study of heterogeneity

    USGS Publications Warehouse

    Kotliar, Natasha B.; Wiens, John A.

    1990-01-01

    We develop a hierarchical model of heterogeneity that provides a framework for classifying patch structure across a range of scales. Patches at lower levels in the hierarchy are more simplistic and correspond to the traditional view of patches. At levels approaching the upper bounds of the hierarchy the internal structure becomes more heterogeneous and boundaries more ambiguous. At each level in the hierarchy, patch structure will be influenced by both contrast among patches as well as the degree of aggregation of patches at lower levels in the hierarchy. We apply this model to foraging theory, but it has wider applications as in the study of habitat selection, population dynamics, and habitat fragmentation. It may also be useful in expanding the realm of landscape ecology beyond the current focus on anthropocentric scales.

  18. Cellular Decomposition Based Hybrid-Hierarchical Control Systems with Applications to Flight Management Systems

    NASA Technical Reports Server (NTRS)

    Caines, P. E.

    1999-01-01

    The work in this research project has been focused on the construction of a hierarchical hybrid control theory which is applicable to flight management systems. The motivation and underlying philosophical position for this work has been that the scale, inherent complexity and the large number of agents (aircraft) involved in an air traffic system imply that a hierarchical modelling and control methodology is required for its management and real time control. In the current work the complex discrete or continuous state space of a system with a small number of agents is aggregated in such a way that discrete (finite state machine or supervisory automaton) controlled dynamics are abstracted from the system's behaviour. High level control may then be either directly applied at this abstracted level, or, if this is in itself of significant complexity, further layers of abstractions may be created to produce a system with an acceptable degree of complexity at each level. By the nature of this construction, high level commands are necessarily realizable at lower levels in the system.

  19. Multi-scale Properties and Processes in Hierarchically-Structured Organic-Inorganic Solids and Surface-Based Microfluidic Systems

    NASA Astrophysics Data System (ADS)

    Messinger, Robert James

    Hierarchically-structured materials and surface-based microfluidic systems exhibit diverse properties that are inherently multi-scale in origin. In particular, different molecular, mesoscopic, and micron-scale properties and processes are often correlated and collectively account for many properties of interest, such as bulk catalytic activities or electrokinetic flow rates. However, such properties and processes often exhibit complex relationships over the different length scales that are not well understood, and consequently, difficult to control. Establishing correlations between them has been challenging, in part due to the difficulty of rigorously characterizing complex, heterogeneous materials and surface-based microfluidic experiments over multiple length scales, particularly at the molecular and mesoscopic levels. Herein, new multi-scale understanding and correlations have been established for different hierarchically-structured organic-inorganic solids or surface-based microfluidic systems, enabling control of material or device properties over discrete length scales. The molecular-level compositions, structures, interactions, and dynamics have been measured in diverse hierarchically-structured materials, such as mesostructured zeolites, mesostructured organosilicas, and organosiloxane foams, and subsequently correlated with their meso- and macroscopic material structures and properties. The results reveal new insights on the molecular-level interactions that govern their syntheses, the resulting local compositions and material structures, and the relationships among material properties over multiple characteristic length scales. Multi-dimensional solid-state nuclear magnetic resonance (NMR) spectroscopy is a cornerstone of these investigations, which enables correlative measurements in multiple frequency dimensions of the through-space or through-bond interactions between the constituent nuclei within the different materials. Other multi

  20. Multiple memory systems as substrates for multiple decision systems.

    PubMed

    Doll, Bradley B; Shohamy, Daphna; Daw, Nathaniel D

    2015-01-01

    It has recently become widely appreciated that value-based decision making is supported by multiple computational strategies. In particular, animal and human behavior in learning tasks appears to include habitual responses described by prominent model-free reinforcement learning (RL) theories, but also more deliberative or goal-directed actions that can be characterized by a different class of theories, model-based RL. The latter theories evaluate actions by using a representation of the contingencies of the task (as with a learned map of a spatial maze), called an "internal model." Given the evidence of behavioral and neural dissociations between these approaches, they are often characterized as dissociable learning systems, though they likely interact and share common mechanisms. In many respects, this division parallels a longstanding dissociation in cognitive neuroscience between multiple memory systems, describing, at the broadest level, separate systems for declarative and procedural learning. Procedural learning has notable parallels with model-free RL: both involve learning of habits and both are known to depend on parts of the striatum. Declarative memory, by contrast, supports memory for single events or episodes and depends on the hippocampus. The hippocampus is thought to support declarative memory by encoding temporal and spatial relations among stimuli and thus is often referred to as a relational memory system. Such relational encoding is likely to play an important role in learning an internal model, the representation that is central to model-based RL. Thus, insofar as the memory systems represent more general-purpose cognitive mechanisms that might subserve performance on many sorts of tasks including decision making, these parallels raise the question whether the multiple decision systems are served by multiple memory systems, such that one dissociation is grounded in the other. Here we investigated the relationship between model-based RL and

  1. 1SWASP J093010.78+533859.5: A possible hierarchical quintuple system

    SciTech Connect

    Koo, Jae-Rim; Lee, Jae Woo; Lee, Byeong-Cheol; Kim, Seung-Lee; Lee, Chung-Uk; Hong, Kyeongsoo; Lee, Dong-Joo; Rey, Soo-Chang

    2014-05-01

    Among quadruples or higher multiplicity stars, only a few doubly eclipsing binary systems have been discovered. They are important targets for understanding the formation and evolution of multiple stellar systems because we can obtain accurate stellar parameters from photometric and spectroscopic studies. We present the observational results of this kind of rare object, 1SWASP J093010.78+533859.5, for which the doubly eclipsing feature had been detected previously from the SuperWASP photometric archive. Individual point-spread function photometry for two objects with a separation of about 1.''9 was performed for the first time in this study. Our time-series photometric data confirms the finding of Lohr et al. that the bright object A is an Algol-type detached eclipsing binary and the fainter B is a W UMa-type contact eclipsing. Using high-resolution optical spectra, we obtained well-defined radial velocity variations of system A. Furthermore, stationary spectral lines were detected that must have originated from a further, previously unrecognized stellar component. It was confirmed by the third object contribution from the light-curve analysis. No spectral feature of system B was detected, probably due to motion blur by long exposure times. We obtained the binary parameters and the absolute dimensions of systems A and B from light-curve synthesis with and without radial velocities, respectively. The primary and secondary components of system A have a spectral type of K1 and K5 main sequences, respectively. Two components of system B have nearly the same type of K3 main sequence. Light variations for both binaries are satisfactorily modeled by using two-spot models with one starspot on each component. We estimated the distances to systems A and B individually. Two systems may have similar distances of about 70 pc and seem to be gravitationally bound with a separation of about 130 AU. In conclusion, we suggest that 1SWASP J093010.78+533859.5 is a quintuple stellar

  2. Distributed Hierarchical Control of Multi-Area Power Systems with Improved Primary Frequency Regulation

    SciTech Connect

    Lian, Jianming; Marinovici, Laurentiu D.; Kalsi, Karanjit; Du, Pengwei; Elizondo, Marcelo A.

    2012-12-12

    The conventional distributed hierarchical control architecture for multi-area power systems is revisited. In this paper, a new distributed hierarchical control architecture is proposed. In the proposed architecture, pilot generators are selected in each area to be equipped with decentralized robust control as a supplementary to the conventional droop speed control. With the improved primary frequency control, the system frequency can be restored to the nominal value without the help of secondary frequency control, which reduces the burden of the automatic generation control for frequency restoration. Moreover, the low frequency inter-area electromechanical oscillations can also be effectively damped. The effectiveness of the proposed distributed hierarchical control architecture is validated through detailed simulations.

  3. HD 181068: a red giant in a triply eclipsing compact hierarchical triple system.

    PubMed

    Derekas, A; Kiss, L L; Borkovits, T; Huber, D; Lehmann, H; Southworth, J; Bedding, T R; Balam, D; Hartmann, M; Hrudkova, M; Ireland, M J; Kovács, J; Mezo, Gy; Moór, A; Niemczura, E; Sarty, G E; Szabó, Gy M; Szabó, R; Telting, J H; Tkachenko, A; Uytterhoeven, K; Benko, J M; Bryson, S T; Maestro, V; Simon, A E; Stello, D; Schaefer, G; Aerts, C; ten Brummelaar, T A; De Cat, P; McAlister, H A; Maceroni, C; Mérand, A; Still, M; Sturmann, J; Sturmann, L; Turner, N; Tuthill, P G; Christensen-Dalsgaard, J; Gilliland, R L; Kjeldsen, H; Quintana, E V; Tenenbaum, P; Twicken, J D

    2011-04-01

    Hierarchical triple systems comprise a close binary and a more distant component. They are important for testing theories of star formation and of stellar evolution in the presence of nearby companions. We obtained 218 days of Kepler photometry of HD 181068 (magnitude of 7.1), supplemented by ground-based spectroscopy and interferometry, which show it to be a hierarchical triple with two types of mutual eclipses. The primary is a red giant that is in a 45-day orbit with a pair of red dwarfs in a close 0.9-day orbit. The red giant shows evidence for tidally induced oscillations that are driven by the orbital motion of the close pair. HD 181068 is an ideal target for studies of dynamical evolution and testing tidal friction theories in hierarchical triple systems. PMID:21474755

  4. HD 181068: a red giant in a triply eclipsing compact hierarchical triple system.

    PubMed

    Derekas, A; Kiss, L L; Borkovits, T; Huber, D; Lehmann, H; Southworth, J; Bedding, T R; Balam, D; Hartmann, M; Hrudkova, M; Ireland, M J; Kovács, J; Mezo, Gy; Moór, A; Niemczura, E; Sarty, G E; Szabó, Gy M; Szabó, R; Telting, J H; Tkachenko, A; Uytterhoeven, K; Benko, J M; Bryson, S T; Maestro, V; Simon, A E; Stello, D; Schaefer, G; Aerts, C; ten Brummelaar, T A; De Cat, P; McAlister, H A; Maceroni, C; Mérand, A; Still, M; Sturmann, J; Sturmann, L; Turner, N; Tuthill, P G; Christensen-Dalsgaard, J; Gilliland, R L; Kjeldsen, H; Quintana, E V; Tenenbaum, P; Twicken, J D

    2011-04-01

    Hierarchical triple systems comprise a close binary and a more distant component. They are important for testing theories of star formation and of stellar evolution in the presence of nearby companions. We obtained 218 days of Kepler photometry of HD 181068 (magnitude of 7.1), supplemented by ground-based spectroscopy and interferometry, which show it to be a hierarchical triple with two types of mutual eclipses. The primary is a red giant that is in a 45-day orbit with a pair of red dwarfs in a close 0.9-day orbit. The red giant shows evidence for tidally induced oscillations that are driven by the orbital motion of the close pair. HD 181068 is an ideal target for studies of dynamical evolution and testing tidal friction theories in hierarchical triple systems.

  5. HERB: A production system for programming with hierarchical expert rule bases: User's manual, HERB Version 1. 0

    SciTech Connect

    Hummel, K.E.

    1987-12-01

    Expert systems are artificial intelligence programs that solve problems requiring large amounts of heuristic knowledge, based on years of experience and tradition. Production systems are domain-independent tools that support the development of rule-based expert systems. This document describes a general purpose production system known as HERB. This system was developed to support the programming of expert systems using hierarchically structured rule bases. HERB encourages the partitioning of rules into multiple rule bases and supports the use of multiple conflict resolution strategies. Multiple rule bases can also be placed on a system stack and simultaneously searched during each interpreter cycle. Both backward and forward chaining rules are supported by HERB. The condition portion of each rule can contain both patterns, which are matched with facts in a data base, and LISP expressions, which are explicitly evaluated in the LISP environment. Properties of objects can also be stored in the HERB data base and referenced within the scope of each rule. This document serves both as an introduction to the principles of LISP-based production systems and as a user's manual for the HERB system. 6 refs., 17 figs.

  6. MULTIPLE ECH LAUNCHER CONTROL SYSTEM

    SciTech Connect

    GREEN,M.T; PONCE,D; GRUNLOH,H.J; ELLIS,R.A; GROSNICKLE,W.H; HUMPHREY,R.L

    2003-10-01

    OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future.

  7. Application of automatic parallel fracturing system on hierarchical and large data structure

    NASA Astrophysics Data System (ADS)

    Tsujimoto, Eiji; Watanabe, Takahiro; Katabuchi, Keitaro; Nogami, Akihiro; Shibayama, Shuji; Sambayashi, Hirokazu; Takaku, Shozo; Takase, Norihiko

    2002-03-01

    TO enable efficient transformation of layout data to Electron Beam lithography drawing data in production, we have developed an automatic parallel-processing fracturing system named Tribune. Tribune can effectively use both parallel and hierarchical processing together to maximize the fracturing performance to easily handle large amounts of layout data. Tribune is designed to effectively use both parallel and hierarchical methods with the aid of cell information known by layout designers. A new fracturing algorithm is employed which fractures patterns whose width is wider than specified critical dimensions to minimize the number of tiny geometries for the improvement of pattern fidelity.

  8. A novel 3D constellation-masked method for physical security in hierarchical OFDMA system.

    PubMed

    Zhang, Lijia; Liu, Bo; Xin, Xiangjun; Liu, Deming

    2013-07-01

    This paper proposes a novel 3D constellation-masked method to ensure the physical security in hierarchical optical orthogonal frequency division multiplexing access (OFDMA) system. The 3D constellation masking is executed on the two levels of hierarchical modulation and among different OFDM subcarriers, which is realized by the masking vectors. The Lorenz chaotic model is adopted for the generation of masking vectors in the proposed scheme. A 9.85 Gb/s encrypted hierarchical QAM OFDM signal is successfully demonstrated in the experiment. The performance of illegal optical network unit (ONU) with different masking vectors is also investigated. The proposed method is demonstrated to be secure and efficient against the commonly known attacks in the experiment.

  9. Multiple testing on standardized mortality ratios: a Bayesian hierarchical model for FDR estimation.

    PubMed

    Ventrucci, Massimo; Scott, E Marian; Cocchi, Daniela

    2011-01-01

    The analysis of large data sets of standardized mortality ratios (SMRs), obtained by collecting observed and expected disease counts in a map of contiguous regions, is a first step in descriptive epidemiology to detect potential environmental risk factors. A common situation arises when counts are collected in small areas, that is, where the expected count is very low, and disease risks underlying the map are spatially correlated. Traditional p-value-based methods, which control the false discovery rate (FDR) by means of Poisson p-values, might achieve small sensitivity in identifying risk in small areas. This problem is the focus of the present work, where a Bayesian approach which performs a test to evaluate the null hypothesis of no risk over each SMR and controls the posterior FDR is proposed. A Bayesian hierarchical model including spatial random effects to allow for extra-Poisson variability is implemented providing estimates of the posterior probabilities that the null hypothesis of absence of risk is true. By means of such posterior probabilities, an estimate of the posterior FDR conditional on the data can be computed. A conservative estimation is needed to achieve the control which is checked by simulation. The availability of this estimate allows the practitioner to determine nonarbitrary FDR-based selection rules to identify high-risk areas according to a preset FDR level. Sensitivity and specificity of FDR-based rules are studied via simulation and a comparison with p-value-based rules is also shown. A real data set is analyzed using rules based on several FDR levels.

  10. Multilevel Compression of Random Walks on Networks Reveals Hierarchical Organization in Large Integrated Systems

    PubMed Central

    Rosvall, Martin; Bergstrom, Carl T.

    2011-01-01

    To comprehend the hierarchical organization of large integrated systems, we introduce the hierarchical map equation, which reveals multilevel structures in networks. In this information-theoretic approach, we exploit the duality between compression and pattern detection; by compressing a description of a random walker as a proxy for real flow on a network, we find regularities in the network that induce this system-wide flow. Finding the shortest multilevel description of the random walker therefore gives us the best hierarchical clustering of the network — the optimal number of levels and modular partition at each level — with respect to the dynamics on the network. With a novel search algorithm, we extract and illustrate the rich multilevel organization of several large social and biological networks. For example, from the global air traffic network we uncover countries and continents, and from the pattern of scientific communication we reveal more than 100 scientific fields organized in four major disciplines: life sciences, physical sciences, ecology and earth sciences, and social sciences. In general, we find shallow hierarchical structures in globally interconnected systems, such as neural networks, and rich multilevel organizations in systems with highly separated regions, such as road networks. PMID:21494658

  11. A Hierarchical Competing Systems Model of the Emergence and Early Development of Executive Function

    ERIC Educational Resources Information Center

    Marcovitch, Stuart; Zelazo, Philip David

    2009-01-01

    The hierarchical competing systems model (HCSM) provides a framework for understanding the emergence and early development of executive function--the cognitive processes underlying the conscious control of behavior--in the context of search for hidden objects. According to this model, behavior is determined by the joint influence of a…

  12. Automating Multiple Software Packages in Simulation Research for Structural Equation Modeling and Hierarchical Linear Modeling

    ERIC Educational Resources Information Center

    Gagne, Phill; Furlow, Carolyn F.

    2009-01-01

    Simulation researchers are sometimes faced with the need to use multiple statistical software packages in the process of conducting their research, potentially having to go between software packages manually. This can be a tedious and time-consuming process that generally motivates researchers to use fewer replications in their simulations than…

  13. Two-stage hierarchical group testing for multiple infections with application to the Infertility Prevention Project

    PubMed Central

    Tebbs, Joshua M.; McMahan, Christopher S.; Bilder, Christopher R.

    2015-01-01

    Summary Screening for sexually transmitted diseases has benefited greatly from the use of group testing (pooled testing) to lower costs. With the development of assays that detect multiple infections, screening practices now involve testing pools of individuals for multiple infections simultaneously. Building on the research for single infection group testing procedures, we examine the performance of group testing for multiple infections. Our work is motivated by chlamydia and gonorrhea testing for the Infertility Prevention Project (IPP), a national program in the United States. We consider a two-stage pooling algorithm currently used to perform testing for the IPP. We first derive the operating characteristics of this algorithm for classification purposes (e.g., expected number of tests, misclassification probabilities, etc.) and identify pool sizes that minimize the expected number of tests. We then develop an expectation-maximization algorithm to estimate probabilities of infection using both group and individual retest responses. Our research shows that group testing can offer large cost savings when classifying individuals for multiple infections and can provide prevalence estimates that are actually more efficient than those from individual testing. PMID:24117173

  14. Effects of fatigue on synergies in a hierarchical system

    PubMed Central

    Singh, Tarkeshwar; Zatsiorsky, Vladimir M.; Latash, Mark L.

    2013-01-01

    We investigated the effect of fatigue produced by timed maximal voluntary contraction (MVC) of the index finger of one of the hands on performance in MVC and accurate cyclic force production tasks in right-handed subjects. Based on earlier studies, we hypothesized that fatigue would produce an increase in the indices of force-stabilizing synergies in both hands as well as between the hands in two-hand tasks. Synergies were defined as co-varied adjustments of commands to fingers (modes) across cycles that stabilized total force. Fatigue caused a significant reduction in the MVC of the exercised as well as the non-exercised hand. Indices of finger enslaving (lack of individuation) increased with fatigue in both hands, although the increase was significant in the exercised hand only. In contrast to the significant effects of fatigue on MVC forces performed by the non-exercised hand, there were no comparable transfer effects on the root mean square errors during accurate force production. During one-hand tasks, both hands showed high indices of force-stabilizing synergies. These indices were larger in the left hand. Fatigue led to a general increase in synergy indices. Exercise by the left hand had stronger effects on synergy indices seen in both hands. Exercise by the right hand showed ipsilateral effects only. Smaller effects of fatigue were observed on accuracy of performance of the force-down segments of the force cycles compared to the force-up segments. For the bimanual tasks, synergies were analyzed at two hierarchical levels, two-hand (four-finger) and within-a-hand (two-finger). An increase in the synergy index with fatigue was observed at the lower (two-finger) level of the hierarchy only. We interpret the lack of effects of fatigue at the upper (two-hand) level as a consequence of a trade-off between synergies at different levels of the hierarchy. The differences between the hands are discussed within the dynamic dominance hypothesis. PMID:23182434

  15. Effects of fatigue on synergies in a hierarchical system.

    PubMed

    Singh, Tarkeshwar; Zatsiorsky, Vladimir M; Latash, Mark L

    2012-12-01

    We investigated the effect of fatigue produced by timed maximal voluntary contraction (MVC) of the index finger of one of the hands on performance in MVC and accurate cyclic force production tasks in right-handed subjects. Based on earlier studies, we hypothesized that fatigue would produce an increase in the indices of force-stabilizing synergies in both hands as well as between the hands in two-hand tasks. Synergies were defined as co-varied adjustments of commands to fingers (modes) across cycles that stabilized total force. Fatigue caused a significant reduction in the MVC of the exercised as well as the non-exercised hand. Indices of finger enslaving (lack of individuation) increased with fatigue in both hands, although the increase was significant in the exercised hand only. In contrast to the significant effects of fatigue on MVC forces performed by the non-exercised hand, there were no comparable transfer effects on the root mean square errors during accurate force production. During one-hand tasks, both hands showed high indices of force-stabilizing synergies. These indices were larger in the left hand. Fatigue led to a general increase in synergy indices. Exercise by the left hand had stronger effects on synergy indices seen in both hands. Exercise by the right hand showed ipsilateral effects only. Smaller effects of fatigue were observed on accuracy of performance of the force-down segments of the force cycles compared to the force-up segments. For the bimanual tasks, synergies were analyzed at two hierarchical levels, two-hand (four-finger) and within-a-hand (two-finger). An increase in the synergy index with fatigue was observed at the lower (two-finger) level of the hierarchy only. We interpret the lack of effects of fatigue at the upper (two-hand) level as a consequence of a trade-off between synergies at different levels of the hierarchy. The differences between the hands are discussed within the dynamic dominance hypothesis. PMID:23182434

  16. Heredity in multiple system atrophy.

    PubMed

    Soma, Hiroyuki; Yabe, Ichiro; Takei, Asako; Fujiki, Naoto; Yanagihara, Tetsuro; Sasaki, Hidenao

    2006-01-15

    We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary spinocerebellar ataxia with a similar clinical phenotype to MSA. The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background.

  17. Bayesian Non-Parametric Hierarchical Modeling for Multiple Membership Data in Grouped Attendance Interventions.

    PubMed

    Savitsky, Terrance D; Paddock, Susan M

    2013-06-01

    We develop a dependent Dirichlet process (DDP) model for repeated measures multiple membership (MM) data. This data structure arises in studies under which an intervention is delivered to each client through a sequence of elements which overlap with those of other clients on different occasions. Our interest concentrates on study designs for which the overlaps of sequences occur for clients who receive an intervention in a shared or grouped fashion whose memberships may change over multiple treatment events. Our motivating application focuses on evaluation of the effectiveness of a group therapy intervention with treatment delivered through a sequence of cognitive behavioral therapy session blocks, called modules. An open-enrollment protocol permits entry of clients at the beginning of any new module in a manner that may produce unique MM sequences across clients. We begin with a model that composes an addition of client and multiple membership module random effect terms, which are assumed independent. Our MM DDP model relaxes the assumption of conditionally independent client and module random effects by specifying a collection of random distributions for the client effect parameters that are indexed by the unique set of module attendances. We demonstrate how this construction facilitates examining heterogeneity in the relative effectiveness of group therapy modules over repeated measurement occasions. PMID:24273629

  18. Bayesian Non-Parametric Hierarchical Modeling for Multiple Membership Data in Grouped Attendance Interventions

    PubMed Central

    Savitsky, Terrance D.; Paddock, Susan M.

    2012-01-01

    We develop a dependent Dirichlet process (DDP) model for repeated measures multiple membership (MM) data. This data structure arises in studies under which an intervention is delivered to each client through a sequence of elements which overlap with those of other clients on different occasions. Our interest concentrates on study designs for which the overlaps of sequences occur for clients who receive an intervention in a shared or grouped fashion whose memberships may change over multiple treatment events. Our motivating application focuses on evaluation of the effectiveness of a group therapy intervention with treatment delivered through a sequence of cognitive behavioral therapy session blocks, called modules. An open-enrollment protocol permits entry of clients at the beginning of any new module in a manner that may produce unique MM sequences across clients. We begin with a model that composes an addition of client and multiple membership module random effect terms, which are assumed independent. Our MM DDP model relaxes the assumption of conditionally independent client and module random effects by specifying a collection of random distributions for the client effect parameters that are indexed by the unique set of module attendances. We demonstrate how this construction facilitates examining heterogeneity in the relative effectiveness of group therapy modules over repeated measurement occasions. PMID:24273629

  19. HIERARCHICAL METHODOLOGY FOR MODELING HYDROGEN STORAGE SYSTEMS. PART I: SCOPING MODELS

    SciTech Connect

    Hardy, B; Donald L. Anton, D

    2008-12-22

    Detailed models for hydrogen storage systems provide essential design information about flow and temperature distributions, as well as, the utilization of a hydrogen storage media. However, before constructing a detailed model it is necessary to know the geometry and length scales of the system, along with its heat transfer requirements, which depend on the limiting reaction kinetics. More fundamentally, before committing significant time and resources to the development of a detailed model, it is necessary to know whether a conceptual storage system design is viable. For this reason, a hierarchical system of models progressing from scoping models to detailed analyses was developed. This paper, which discusses the scoping models, is the first in a two part series that presents a collection of hierarchical models for the design and evaluation of hydrogen storage systems.

  20. Priming Effects Associated with the Hierarchical Levels of Classification Systems

    ERIC Educational Resources Information Center

    Loehrlein, Aaron J.

    2012-01-01

    The act of categorization produces conceptual representations in memory while knowledge organization (KO) systems provide conceptual representations that are used in information storage and retrieval systems. Previous research has explored how KO systems can be designed to resemble the user's internal conceptual structures. However, the more…

  1. Multiple channel data acquisition system

    DOEpatents

    Crawley, H. Bert; Rosenberg, Eli I.; Meyer, W. Thomas; Gorbics, Mark S.; Thomas, William D.; McKay, Roy L.; Homer, Jr., John F.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

  2. Multiple channel data acquisition system

    DOEpatents

    Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

  3. TOWARD HIGHLY SECURE AND AUTONOMIC COMPUTING SYSTEMS: A HIERARCHICAL APPROACH

    SciTech Connect

    Lee, Hsien-Hsin S

    2010-05-11

    The overall objective of this research project is to develop novel architectural techniques as well as system software to achieve a highly secure and intrusion-tolerant computing system. Such system will be autonomous, self-adapting, introspective, with self-healing capability under the circumstances of improper operations, abnormal workloads, and malicious attacks. The scope of this research includes: (1) System-wide, unified introspection techniques for autonomic systems, (2) Secure information-flow microarchitecture, (3) Memory-centric security architecture, (4) Authentication control and its implication to security, (5) Digital right management, (5) Microarchitectural denial-of-service attacks on shared resources. During the period of the project, we developed several architectural techniques and system software for achieving a robust, secure, and reliable computing system toward our goal.

  4. Detailed Modeling of Higher Order Hierarchical Kepler Star Systems

    NASA Astrophysics Data System (ADS)

    Gore, Joanna; Orosz, Jerome A.

    2016-06-01

    Most stars have stellar companions (i.e. they exist in double, triple, or higher order configurations). Binary star systems are those which contain two stars. These systems are valued scientifically because they allow for the measurement of fundamental stellar properties such as masses and radii. These properties in turn allow for detailed studies of stellar evolution. The Kepler space telescope has discovered roughly 2900 eclipsing binary stars in its field of view. Various studies have shown that roughly 20% of the Kepler eclipsing binaries contain companions are are most likely triple star systems. We present a preliminary survey of the orbital properties of the tertiary bodies in a sample of thirty triple systems. In addition, a small number of the triple systems show eclipse events due to the third star. We present the results of detailed modeling of two of these systems, and discuss how in some cases these triple systems allow for extremely precise measurements of the fundamental stellar parameters.

  5. Determining the Bayesian optimal sampling strategy in a hierarchical system.

    SciTech Connect

    Grace, Matthew D.; Ringland, James T.; Boggs, Paul T.; Pebay, Philippe Pierre

    2010-09-01

    Consider a classic hierarchy tree as a basic model of a 'system-of-systems' network, where each node represents a component system (which may itself consist of a set of sub-systems). For this general composite system, we present a technique for computing the optimal testing strategy, which is based on Bayesian decision analysis. In previous work, we developed a Bayesian approach for computing the distribution of the reliability of a system-of-systems structure that uses test data and prior information. This allows for the determination of both an estimate of the reliability and a quantification of confidence in the estimate. Improving the accuracy of the reliability estimate and increasing the corresponding confidence require the collection of additional data. However, testing all possible sub-systems may not be cost-effective, feasible, or even necessary to achieve an improvement in the reliability estimate. To address this sampling issue, we formulate a Bayesian methodology that systematically determines the optimal sampling strategy under specified constraints and costs that will maximally improve the reliability estimate of the composite system, e.g., by reducing the variance of the reliability distribution. This methodology involves calculating the 'Bayes risk of a decision rule' for each available sampling strategy, where risk quantifies the relative effect that each sampling strategy could have on the reliability estimate. A general numerical algorithm is developed and tested using an example multicomponent system. The results show that the procedure scales linearly with the number of components available for testing.

  6. Estimating the prevalence of multiple diseases from two-stage hierarchical pooling.

    PubMed

    Warasi, Md S; Tebbs, Joshua M; McMahan, Christopher S; Bilder, Christopher R

    2016-09-20

    Testing protocols in large-scale sexually transmitted disease screening applications often involve pooling biospecimens (e.g., blood, urine, and swabs) to lower costs and to increase the number of individuals who can be tested. With the recent development of assays that detect multiple diseases, it is now common to test biospecimen pools for multiple infections simultaneously. Recent work has developed an expectation-maximization algorithm to estimate the prevalence of two infections using a two-stage, Dorfman-type testing algorithm motivated by current screening practices for chlamydia and gonorrhea in the USA. In this article, we have the same goal but instead take a more flexible Bayesian approach. Doing so allows us to incorporate information about assay uncertainty during the testing process, which involves testing both pools and individuals, and also to update information as individuals are tested. Overall, our approach provides reliable inference for disease probabilities and accurately estimates assay sensitivity and specificity even when little or no information is provided in the prior distributions. We illustrate the performance of our estimation methods using simulation and by applying them to chlamydia and gonorrhea data collected in Nebraska. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27090057

  7. The two stages hierarchical unsupervised learning system for complex dynamic scene recognition

    NASA Astrophysics Data System (ADS)

    Graham, James; O'Connor, Alan; Ternovskiy, Igor V.; Ilin, Roman

    2013-06-01

    The two stage hierarchical unsupervised learning system has been proposed for modeling complex dynamic surveillance and cyberspace systems. Using a modification of the expectation maximization learning approach, we introduced a three layer approach to learning concepts from input data: features, objects, and situations. Using the Bernoulli model, this approach models each situation as a collection of objects, and each object as a collection of features. Further complexity is added with the addition of clutter features and clutter objects. During the learning process, at the lowest level, only binary feature information (presence or absence) is provided. The system attempts to simultaneously determine the probabilities of the situation and presence of corresponding objects from the detected features. The proposed approach demonstrated robust performance after a short training period. This paper discusses this hierarchical learning system in a broader context of different feedback mechanisms between layers and highlights challenges on the road to practical applications.

  8. Set-point changes in hierarchically-arranged thermogenic systems

    NASA Technical Reports Server (NTRS)

    Horowitz, J. M.

    1984-01-01

    Rats acclimated to either 23 or 5 C were concurrently exposed to cold and hypergravic fields to test the proposal that mammals have parallel controllers for thermoregulation. The two groups of rats were used to evaluate the different relative contributions of shivering and nonshivering thermogenesis to the increased oxygen consumption of the cold-exposed rats in hypergravic fields. The lower magnitude of the cold-induced oxygen consumption observed when cold-exposed rats are moved from 1 G to hypergravic fields is probably due to an inactivation of shivering rather than nonshivering thermogenesis. The observation that shivering, but not nonshivering thermogenesis, appears to be impaired by hypergravic fields is consistent with the representation of central thermoregulation by multiple controllers.

  9. [Hormonal activity of the hypophysis-gonadal system in male hamadryas baboons in relationship to their hierarchical position].

    PubMed

    Taranov, A G; Shashk-ogly, L K; Goncharov, N P

    1986-03-01

    Hierarchic status-dependent hormonal activity of pituitary-gonadal system was studied in an isolated group of hamadryas baboons. Testosterone level was higher in dominating males. The level of sex hormone was higher in aged animals with great muscle mass. No correlation was observed between hierarchic status of hamadryas baboon males and the blood level of luteinizing hormone.

  10. Effect of stiffness of multi-level hierarchical attachment system on adhesion enhancement.

    PubMed

    Kim, Tae Wan; Bhushan, Bharat

    2007-10-01

    Geckos are known for their remarkable ability to cling on and detach from ceilings and walls using a unique attachment system. Their foot pads are covered by a large number of small hair (setae) that contain many branches per seta with a lower level of spatulae. This hierarchical structure gives the gecko adaptability to create a large real area of contact with rough surfaces. In this study, using the three-level hierarchical model recently developed to simulate a gecko seta contacting with random rough surface, the effects of spring stiffness and number of springs on the adhesion enhancement of multi-level hierarchical model are investigated. One- and three-level hierarchically structured spring models with different spring stiffnesses and number of springs on each level in contact with various rough surfaces are considered. The efficiency of attachment-the adhesion coefficient, the adhesion force, the number of contacts and the adhesion energy-for the three-level models with different stiffness is investigated in contact with different rough surfaces.

  11. Hierarchical system for autonomous sensing-healing of delamination in large-scale composite structures

    NASA Astrophysics Data System (ADS)

    Minakuchi, Shu; Sun, Denghao; Takeda, Nobuo

    2014-10-01

    This study combines our hierarchical fiber-optic-based delamination detection system with a microvascular self-healing material to develop the first autonomous sensing-healing system applicable to large-scale composite structures. In this combined system, embedded vascular modules are connected through check valves to a surface-mounted supply tube of a pressurized healing agent while fiber-optic-based sensors monitor the internal pressure of these vascular modules. When delamination occurs, the healing agent flows into the vascular modules breached by the delamination and infiltrates the damage for healing. At the same time, the pressure sensors identify the damaged modules by detecting internal pressure changes. This paper begins by describing the basic concept of the combined system and by discussing the advantages that arise from its hierarchical nature. The feasibility of the system is then confirmed through delamination infiltration tests. Finally, the hierarchical system is validated in a plate specimen by focusing on the detection and infiltration of the damage. Its self-diagnostic function is also demonstrated.

  12. Performance Modeling of Network-Attached Storage Device Based Hierarchical Mass Storage Systems

    NASA Technical Reports Server (NTRS)

    Menasce, Daniel A.; Pentakalos, Odysseas I.

    1995-01-01

    Network attached storage devices improve I/O performance by separating control and data paths and eliminating host intervention during the data transfer phase. Devices are attached to both a high speed network for data transfer and to a slower network for control messages. Hierarchical mass storage systems use disks to cache the most recently used files and a combination of robotic and manually mounted tapes to store the bulk of the files in the file system. This paper shows how queuing network models can be used to assess the performance of hierarchical mass storage systems that use network attached storage devices as opposed to host attached storage devices. Simulation was used to validate the model. The analytic model presented here can be used, among other things, to evaluate the protocols involved in 1/0 over network attached devices.

  13. Hierarchical Bayesian regularization of reconstructions for diffuse optical tomography using multiple priors

    PubMed Central

    Abdelnour, Farras; Genovese, Christopher; Huppert, Theodore

    2010-01-01

    Diffuse optical tomography (DOT) is a non-invasive brain imaging technique that uses low-levels of near-infrared light to measure optical absorption changes due to regional blood flow and blood oxygen saturation in the brain. By arranging light sources and detectors in a grid over the surface of the scalp, DOT studies attempt to spatially localize changes in oxy- and deoxy-hemoglobin in the brain that result from evoked brain activity during functional experiments. However, the reconstruction of accurate spatial images of hemoglobin changes from DOT data is an ill-posed linearized inverse problem, which requires model regularization to yield appropriate solutions. In this work, we describe and demonstrate the application of a parametric restricted maximum likelihood method (ReML) to incorporate multiple statistical priors into the recovery of optical images. This work is based on similar methods that have been applied to the inverse problem for magnetoencephalography (MEG). Herein, we discuss the adaptation of this model to DOT and demonstrate that this approach provides a means to objectively incorporate reconstruction constraints and demonstrate this approach through a series of simulated numerical examples. PMID:21258532

  14. Hierarchical spin-orbital polarization of a giant Rashba system.

    PubMed

    Bawden, Lewis; Riley, Jonathan M; Kim, Choong H; Sankar, Raman; Monkman, Eric J; Shai, Daniel E; Wei, Haofei I; Lochocki, Edward B; Wells, Justin W; Meevasana, Worawat; Kim, Timur K; Hoesch, Moritz; Ohtsubo, Yoshiyuki; Le Fèvre, Patrick; Fennie, Craig J; Shen, Kyle M; Chou, Fangcheng; King, Phil D C

    2015-09-01

    The Rashba effect is one of the most striking manifestations of spin-orbit coupling in solids and provides a cornerstone for the burgeoning field of semiconductor spintronics. It is typically assumed to manifest as a momentum-dependent splitting of a single initially spin-degenerate band into two branches with opposite spin polarization. Combining polarization-dependent and resonant angle-resolved photoemission measurements with density functional theory calculations, we show that the two "spin-split" branches of the model giant Rashba system BiTeI additionally develop disparate orbital textures, each of which is coupled to a distinct spin configuration. This necessitates a reinterpretation of spin splitting in Rashba-like systems and opens new possibilities for controlling spin polarization through the orbital sector. PMID:26601268

  15. Hierarchical spin-orbital polarization of a giant Rashba system

    PubMed Central

    Bawden, Lewis; Riley, Jonathan M.; Kim, Choong H.; Sankar, Raman; Monkman, Eric J.; Shai, Daniel E.; Wei, Haofei I.; Lochocki, Edward B.; Wells, Justin W.; Meevasana, Worawat; Kim, Timur K.; Hoesch, Moritz; Ohtsubo, Yoshiyuki; Le Fèvre, Patrick; Fennie, Craig J.; Shen, Kyle M.; Chou, Fangcheng; King, Phil D. C.

    2015-01-01

    The Rashba effect is one of the most striking manifestations of spin-orbit coupling in solids and provides a cornerstone for the burgeoning field of semiconductor spintronics. It is typically assumed to manifest as a momentum-dependent splitting of a single initially spin-degenerate band into two branches with opposite spin polarization. Combining polarization-dependent and resonant angle-resolved photoemission measurements with density functional theory calculations, we show that the two “spin-split” branches of the model giant Rashba system BiTeI additionally develop disparate orbital textures, each of which is coupled to a distinct spin configuration. This necessitates a reinterpretation of spin splitting in Rashba-like systems and opens new possibilities for controlling spin polarization through the orbital sector. PMID:26601268

  16. INTERFEROMETRIC OBSERVATIONS OF THE HIERARCHICAL TRIPLE SYSTEM ALGOL

    SciTech Connect

    Csizmadia, Sz.; Borkovits, T.; Paragi, Zs.; Abraham, P.; Szabados, L.; Mosoni, L.; Sturmann, L.; Sturmann, J.; Farrington, C.; McAlister, H. A.; Brummelaar, T. A. ten; Turner, N. H.; Klagyivik, P.

    2009-11-01

    Algol is a triple stellar system consisting of a close semidetached binary orbited by a third object. Due to the disputed spatial orientation of the close pair, the third body perturbation of this pair is a subject of much research. In this study, we determine the spatial orientation of the close pair orbital plane using the CHARA Array, a six-element optical/IR interferometer located on Mount Wilson, and state-of-the-art e-EVN interferometric techniques. We find that the longitude of the line of nodes for the close pair is OMEGA{sub 1} = 48 deg. +- 2 deg. and the mutual inclination of the orbital planes of the close and the wide pairs is 95 deg. +- 3 deg. This latter value differs by 5{sup 0} from the formerly known 100 deg., which would imply a very fast inclination variation of the system, not borne out by the photometric observations. We also investigated the dynamics of the system with numerical integration of the equations of motions using our result as an initial condition. We found large variations in the inclination of the close pair (its amplitude approx170{sup 0}) with a period of about 20 millennia. This result is in good agreement with the photometrically observed change of amplitude in Algol's primary minimum.

  17. The structure of non-hierarchical triple system stability regions

    NASA Astrophysics Data System (ADS)

    Martynova, A. I.; Orlov, V. V.; Rubinov, A. V.

    2009-08-01

    A detailed study of the two-dimensional initial conditions region section in the planar three-body problem is performed. The initial conditions for the three well-known stable periodic orbits (the Schubart’s orbit, the Broucke’s orbit and the eight-like orbit) belong to this section. Continuous stability regions (for the fixed integration interval) generated by these periodic orbits are found. Zones of the quick stability violation are outlined. The analysis of some concrete trajectories coming from various stability regions is performed. In particular, trajectories possessing varying number of “eights” formed by moving triple system components are discovered. Orbits with librations are also found. The new periodic orbit originated from the zone siding with the Schubart’s orbit region is discovered. This orbit has reversibility points (each of the outer bodies possess a reversibility point) and two points of close double approach of the central body to each of the outer bodies. The influence of the numerical integration accuracy on the results is studied. The stability regions structure is preserved during calculations with different values of the precision parameter, numerical integration methods and regularization algorithms of the equations of motion.

  18. Inventory and Billing Systems for Multiple Users.

    ERIC Educational Resources Information Center

    Frazier, Lavon

    1985-01-01

    Washington State University developed a comprehensive supplies inventory system and a generalized billing system with multiple users in mind. The inventory management system and the service center billing system are described. (Author/MLW)

  19. Dynamical structure of the multiple stellar system HD164492

    NASA Astrophysics Data System (ADS)

    González, J. F.; Veramendi, M. E.

    2016-08-01

    HD 164492 is a Trapezium-like stellar system with one O-type and several early B-type components immersed in an active star forming region (M20). The relevance of this system has increased after the recent discovery that one of its visual components, HD 164492C, is a spectroscopic triple with a remarkable magnetic field. As a complement of those spectro-polarimetric studies, we present here a survey of the stellar components in the region using available Hubble Space Telescope images. By applying aperture and point spread function (PSF) photometry, we measure accurate separations of close visual pairs and detect new visual companions. Combining these results with previous spectroscopic and photometric studies, we estimate physical separations for 20 probable members of this high-order multiple system. The most interesting feature is that even though it has a global Trapezium-like structure, some of its components are stable binary subsystems organized hierarchically.

  20. Models of Multiple System Atrophy

    PubMed Central

    Fellner, Lisa; Wenning, Gregor K.; Stefanova, Nadia

    2016-01-01

    Multiple system atrophy (MSA) is a predominantly sporadic, adult-onset, fatal neurodegenerative disease of unknown etiology. MSA is characterized by autonomic failure, levodopa-unresponsive parkinsonism, cerebellar ataxia and pyramidal signs in any combination. MSA belongs to a group of neurodegenerative disorders termed α-synucleinopathies, which also include Parkinson’s disease and dementia with Lewy bodies. Their common pathological feature is the occurrence of abnormal α-synuclein positive inclusions in neurons or glial cells. In MSA, the main cell type presenting aggregates composed of α-synuclein are oligodendroglial cells. This pathological hallmark, also called glial cytoplasmic inclusions (GCIs), is associated with progressive and profound neuronal loss in various regions of the brain. The development of animal models of MSA is justified by the limited understanding of the mechanisms of neurodegeneration and GCIs formation, which is paralleled by a lack of therapeutic strategies. Two main types of rodent models have been generated to replicate different features of MSA neuropathology. On one hand, neurotoxin-based models have been produced to reproduce neuronal loss in substantia nigra pars compacta and striatum. On the other hand, transgenic mouse models with overexpression of α-synuclein in oligodendroglia have been used to reproduce GCIs-related pathology. This chapter gives an overview of the atypical Parkinson’s syndrome MSA and summarizes the currently available MSA animal models and their relevance for pre-clinical testing of disease-modifying therapies. PMID:24338664

  1. Assessing Short-Term Voltage Stability of Electric Power Systems by a Hierarchical Intelligent System.

    PubMed

    Xu, Yan; Zhang, Rui; Zhao, Junhua; Dong, Zhao Yang; Wang, Dianhui; Yang, Hongming; Wong, Kit Po

    2016-08-01

    In the smart grid paradigm, growing integration of large-scale intermittent renewable energies has introduced significant uncertainties to the operations of an electric power system. This makes real-time dynamic security assessment (DSA) a necessity to enable enhanced situational-awareness against the risk of blackouts. Conventional DSA methods are mainly based on the time-domain simulation, which are insufficiently fast and knowledge-poor. In recent years, the intelligent system (IS) strategy has been identified as a promising approach to facilitate real-time DSA. While previous works mainly concentrate on the rotor angle stability, this paper focuses on another yet increasingly important dynamic insecurity phenomenon-the short-term voltage instability, which involves fast and complex load dynamics. The problem is modeled as a classification subproblem for transient voltage collapse and a prediction subproblem for unacceptable dynamic voltage deviation. A hierarchical IS is developed to address the two subproblems sequentially. The IS is based on ensemble learning of random-weights neural networks and is implemented in an offline training, a real-time application, and an online updating pattern. The simulation results on the New England 39-bus system verify its superiority in both learning speed and accuracy over some state-of-the-art learning algorithms.

  2. Assessing Short-Term Voltage Stability of Electric Power Systems by a Hierarchical Intelligent System.

    PubMed

    Xu, Yan; Zhang, Rui; Zhao, Junhua; Dong, Zhao Yang; Wang, Dianhui; Yang, Hongming; Wong, Kit Po

    2016-08-01

    In the smart grid paradigm, growing integration of large-scale intermittent renewable energies has introduced significant uncertainties to the operations of an electric power system. This makes real-time dynamic security assessment (DSA) a necessity to enable enhanced situational-awareness against the risk of blackouts. Conventional DSA methods are mainly based on the time-domain simulation, which are insufficiently fast and knowledge-poor. In recent years, the intelligent system (IS) strategy has been identified as a promising approach to facilitate real-time DSA. While previous works mainly concentrate on the rotor angle stability, this paper focuses on another yet increasingly important dynamic insecurity phenomenon-the short-term voltage instability, which involves fast and complex load dynamics. The problem is modeled as a classification subproblem for transient voltage collapse and a prediction subproblem for unacceptable dynamic voltage deviation. A hierarchical IS is developed to address the two subproblems sequentially. The IS is based on ensemble learning of random-weights neural networks and is implemented in an offline training, a real-time application, and an online updating pattern. The simulation results on the New England 39-bus system verify its superiority in both learning speed and accuracy over some state-of-the-art learning algorithms. PMID:26441430

  3. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle.

    PubMed

    Peng, Jiankun; He, Hongwen; Liu, Wei; Guo, Hongqiang

    2015-01-01

    This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved.

  4. Hierarchical graphs for better annotations of rule-based models of biochemical systems

    SciTech Connect

    Hu, Bin; Hlavacek, William

    2009-01-01

    In the graph-based formalism of the BioNetGen language (BNGL), graphs are used to represent molecules, with a colored vertex representing a component of a molecule, a vertex label representing the internal state of a component, and an edge representing a bond between components. Components of a molecule share the same color. Furthermore, graph-rewriting rules are used to represent molecular interactions, with a rule that specifies addition (removal) of an edge representing a class of association (dissociation) reactions and with a rule that specifies a change of vertex label representing a class of reactions that affect the internal state of a molecular component. A set of rules comprises a mathematical/computational model that can be used to determine, through various means, the system-level dynamics of molecular interactions in a biochemical system. Here, for purposes of model annotation, we propose an extension of BNGL that involves the use of hierarchical graphs to represent (1) relationships among components and subcomponents of molecules and (2) relationships among classes of reactions defined by rules. We illustrate how hierarchical graphs can be used to naturally document the structural organization of the functional components and subcomponents of two proteins: the protein tyrosine kinase Lck and the T cell receptor (TCR)/CD3 complex. Likewise, we illustrate how hierarchical graphs can be used to document the similarity of two related rules for kinase-catalyzed phosphorylation of a protein substrate. We also demonstrate how a hierarchical graph representing a protein can be encoded in an XML-based format.

  5. Dystonia in multiple system atrophy

    PubMed Central

    Boesch, S; Wenning, G; Ransmayr, G; Poewe, W

    2002-01-01

    Objective: To delineate the frequency and nature of dystonia in multiple system atrophy (MSA). Methods: a cohort of 24 patients with clinically probable MSA over the past 10 years were prospectively followed up. Motor features were either dominated by parkinsonism (MSA-P subtype, n=18) or cerebellar ataxia (MSA-C, n=6). Classification of dystonic features and their changes with time was based on clinical observation during 6–12 monthly follow up visits. Parkinsonian features and complications of drug therapy were assessed. Most patients (22/24) died during the observation period. Neuropathological examination was confirmatory in all of the five necropsied patients. Results: At first neurological visit dystonia was present in 11 (46%) patients all of whom had been levodopa naive at this time point. Six patients (25%) exhibited cervical dystonia (antecollis) (MSA-P n=4, MSA-C n=2), five patients (21%) showed unilateral limb dystonia (MSA-P n=4; MSA-C n=1). A definite initial response to levodopa treatment was seen in 15/18 patients with MSA-P, but in none of the six patients with MSA-C. A subgroup of 12 patients with MSA-P developed levodopa induced dyskinesias 2.3 years (range 0.5–4) after initiation of levodopa therapy. Most patients had peak dose craniocervical dystonia; however, some patients experienced limb or generalised dystonia. Isolated peak dose limb chorea occurred in only one patient. Conclusion: The prospective clinical study suggests that dystonia is common in untreated MSA-P. This finding may reflect younger age at disease onset and putaminal pathology in MSA-P. Levodopa induced dyskinesias were almost exclusively dystonic affecting predominantly craniocervical musculature. Future studies are required to elucidate the underlying pathophysiology of dystonia in MSA. PMID:11861684

  6. Obliquities of Kepler stars: comparison of single- and multiple-transit systems

    SciTech Connect

    Morton, Timothy D.; Winn, Joshua N.

    2014-11-20

    The stellar obliquity of a transiting planetary system can be constrained by combining measurements of the star's rotation period, radius, and projected rotational velocity. Here, we present a hierarchical Bayesian technique for recovering the obliquity distribution of a population of transiting planetary systems and apply it to a sample of 70 Kepler objects of interest. With ≈95% confidence, we find that the obliquities of stars with only a single detected transiting planet are systematically larger than those with multiple detected transiting planets. This suggests that a substantial fraction of Kepler's single-transiting systems represent dynamically hotter, less orderly systems than the 'pancake-flat' multiple-transiting systems.

  7. Search process evaluation for a hierarchical menu system by Markov chains

    NASA Astrophysics Data System (ADS)

    Takagi, Hideaki; Kitajima, Muneo; Yamamoto, Tetsuo; Zhang, Yongbing

    2001-07-01

    When computers are used to execute tasks, it is often necessary for the user to locate a target item in a menu or a list. For example, users of word processors and spreadsheet applications select appropriate commands in a hierarchical menu to display dialog boxes and edit file or table attributes. To locate the desired information on the World Wide Web, users select the most appropriate candidate out of those presented by a search engine, and proceed through a series of hyperlinks that appear to be related to the task. This paper applies a cognitive model of the user's item selection process to the task of target search in a hierarchical menu system that contains one or more of the following four operations: (1) item selection on the basis of similarity to the task, (2) consideration in various ways of the selection history when making the next selection, (3) backtracking when an appropriate item is not present among those selectable at a given point in time, and (4) abandoning the task unachieved. We model this selection process with Markov chains. We calculate the probability that task goals are achieved and the average number of selections to make until the task goals are achieved. Finally we use these results to propose a method of evaluating the structures of hierarchical menus and links on a website.

  8. A debugging system for azimuthally acoustic logging tools based on modular and hierarchical design ideas

    NASA Astrophysics Data System (ADS)

    Zhang, K.; Ju, X. D.; Lu, J. Q.; Men, B. Y.

    2016-08-01

    On the basis of modular and hierarchical design ideas, this study presents a debugging system for an azimuthally sensitive acoustic bond tool (AABT). The debugging system includes three parts: a personal computer (PC), embedded front-end machine and function expansion boards. Modular and hierarchical design ideas are conducted in all design and debug processes. The PC communicates with the front-end machine via the Internet, and the front-end machine and function expansion boards connect each other by the extended parallel bus. In this method, the three parts of the debugging system form stable and high-speed data communication. This study not only introduces the system-level debugging and sub-system level debugging of the tool but also the debugging of the analogue signal processing board, which is important and greatly used in logging tools. Experiments illustrate that the debugging system can greatly improve AABT verification and calibration efficiency and that, board-level debugging can examine and improve analogue signal processing boards. The design thinking is clear and the design structure is reasonable, thus making it easy to extend and upgrade the debugging system.

  9. Risk Assessment for Mobile Systems Through a Multilayered Hierarchical Bayesian Network.

    PubMed

    Li, Shancang; Tryfonas, Theo; Russell, Gordon; Andriotis, Panagiotis

    2016-08-01

    Mobile systems are facing a number of application vulnerabilities that can be combined together and utilized to penetrate systems with devastating impact. When assessing the overall security of a mobile system, it is important to assess the security risks posed by each mobile applications (apps), thus gaining a stronger understanding of any vulnerabilities present. This paper aims at developing a three-layer framework that assesses the potential risks which apps introduce within the Android mobile systems. A Bayesian risk graphical model is proposed to evaluate risk propagation in a layered risk architecture. By integrating static analysis, dynamic analysis, and behavior analysis in a hierarchical framework, the risks and their propagation through each layer are well modeled by the Bayesian risk graph, which can quantitatively analyze risks faced to both apps and mobile systems. The proposed hierarchical Bayesian risk graph model offers a novel way to investigate the security risks in mobile environment and enables users and administrators to evaluate the potential risks. This strategy allows to strengthen both app security as well as the security of the entire system. PMID:27076477

  10. The stability of tidal equilibrium for hierarchical star-planet-moon systems

    NASA Astrophysics Data System (ADS)

    Adams, Fred C.; Bloch, Anthony M.

    2016-11-01

    Motivated by the current search for exomoons, this paper considers the stability of tidal equilibrium for hierarchical three-body systems containing a star, a planet, and a moon. In this treatment, the energy and angular momentum budgets include contributions from the planetary orbit, lunar orbit, stellar spin, planetary spin, and lunar spin. The goal is to determine the optimized energy state of the system subject to the constraint of constant angular momentum. Because of the lack of a closed form solution for the full three-body problem, however, we must use an approximate description of the orbits. We first consider the Keplerian limit and find that the critical energy states are saddle points, rather than minima, so that these hierarchical systems have no stable tidal equilibrium states. We then generalize the calculation so that the lunar orbit is described by a time-averaged version of the circular restricted three-body problem. In this latter case, the critical energy state is a shallow minimum, so that a tidal equilibrium state exists. In both cases, however, the lunar orbit for the critical point lies outside the boundary (roughly half the Hill radius) where (previous) numerical simulations indicate dynamical instability. These results suggest that star-planet-moon systems have no viable long-term stable states analogous to those found for two-body systems.

  11. Design of integrated flight/fire control system for armed helicopters: multi-strata hierarchical control

    NASA Astrophysics Data System (ADS)

    Zhao, Jia; Yu, Zhi; Sheng, Gongzhang

    2006-11-01

    Traditional Integrated Flight/Fire Control (IFFC) system using the flight/fire coupler made the system functional uncoupling difficult. Based on the multi-strata hierarchical control theory, a new IFFC system of armed helicopter for air-to-ground gunnery mode was designed. It consisted of two level loops: the Space Pointing Track Loop and Tactical Mission Loop. In the first loop, two-degree-of-freedom (TDF) H∞ method was applied to realize the uncouple control of tree attitude channels of helicopter. In the second loop, the target state estimator and fire control algorithm were designed to provide the first loop with expected attitude pointing. The system discards the flight/fire coupler and decreases the coupling effect of the level loops. Simulation results show that the system can achieve the automatic tracking and aiming process with good performance and strong robustness in different target maneuvers. This design method can also be generalized to the fixed-wing IFFC system.

  12. Multiple target laser ablation system

    DOEpatents

    Mashburn, Douglas N.

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  13. Multiple target laser ablation system

    DOEpatents

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  14. Constructive Multiple-Choice Testing System

    ERIC Educational Resources Information Center

    Park, Jooyong

    2010-01-01

    The newly developed computerized Constructive Multiple-choice Testing system is introduced. The system combines short answer (SA) and multiple-choice (MC) formats by asking examinees to respond to the same question twice, first in the SA format, and then in the MC format. This manipulation was employed to collect information about the two…

  15. An Intrusion Detection System Based on Multi-Level Clustering for Hierarchical Wireless Sensor Networks.

    PubMed

    Butun, Ismail; Ra, In-Ho; Sankar, Ravi

    2015-01-01

    In this work, an intrusion detection system (IDS) framework based on multi-level clustering for hierarchical wireless sensor networks is proposed. The framework employs two types of intrusion detection approaches: (1) "downward-IDS (D-IDS)" to detect the abnormal behavior (intrusion) of the subordinate (member) nodes; and (2) "upward-IDS (U-IDS)" to detect the abnormal behavior of the cluster heads. By using analytical calculations, the optimum parameters for the D-IDS (number of maximum hops) and U-IDS (monitoring group size) of the framework are evaluated and presented. PMID:26593915

  16. An Intrusion Detection System Based on Multi-Level Clustering for Hierarchical Wireless Sensor Networks

    PubMed Central

    Butun, Ismail; Ra, In-Ho; Sankar, Ravi

    2015-01-01

    In this work, an intrusion detection system (IDS) framework based on multi-level clustering for hierarchical wireless sensor networks is proposed. The framework employs two types of intrusion detection approaches: (1) “downward-IDS (D-IDS)” to detect the abnormal behavior (intrusion) of the subordinate (member) nodes; and (2) “upward-IDS (U-IDS)” to detect the abnormal behavior of the cluster heads. By using analytical calculations, the optimum parameters for the D-IDS (number of maximum hops) and U-IDS (monitoring group size) of the framework are evaluated and presented. PMID:26593915

  17. Use of a Hierarchical Oligonucleotide Primer Extension Approach for Multiplexed Relative Abundance Analysis of Methanogens in Anaerobic Digestion Systems

    PubMed Central

    Chuang, Hui-Ping; Hsu, Mao-Hsuan; Chen, Wei-Yu

    2013-01-01

    In this study, we established a rapid multiplex method to detect the relative abundances of amplified 16S rRNA genes from known cultivatable methanogens at hierarchical specificities in anaerobic digestion systems treating industrial wastewater and sewage sludge. The method was based on the hierarchical oligonucleotide primer extension (HOPE) technique and combined with a set of 27 primers designed to target the total archaeal populations and methanogens from 22 genera within 4 taxonomic orders. After optimization for their specificities and detection sensitivity under the conditions of multiple single-nucleotide primer extension reactions, the HOPE approach was applied to analyze the methanogens in 19 consortium samples from 7 anaerobic treatment systems (i.e., 513 reactions). Among the samples, the methanogen populations detected with order-level primers accounted for >77.2% of the PCR-amplified 16S rRNA genes detected using an Archaea-specific primer. The archaeal communities typically consisted of 2 to 7 known methanogen genera within the Methanobacteriales, Methanomicrobiales, and Methanosarcinales and displayed population dynamic and spatial distributions in anaerobic reactor operations. Principal component analysis of the HOPE data further showed that the methanogen communities could be clustered into 3 distinctive groups, in accordance with the distribution of the Methanosaeta, Methanolinea, and Methanomethylovorans, respectively. This finding suggested that in addition to acetotrophic and hydrogenotrophic methanogens, the methylotrophic methanogens might play a key role in the anaerobic treatment of industrial wastewater. Overall, the results demonstrated that the HOPE approach is a specific, rapid, and multiplexing platform to determine the relative abundances of targeted methanogens in PCR-amplified 16S rRNA gene products. PMID:24077716

  18. Evolutionary Processes in Multiple Systems

    SciTech Connect

    Eggleton, P P; Kisseleva-Eggleton, L

    2006-02-14

    There are several ways in which triple stars can evolve in somewhat unusual ways. They discuss two situations where Case A Roche-lobe overflow, followed by a merger, can produce anomalous wide binaries such as {gamma} Per; and Kozai cycles in triples with non-parallel orbits, which can produce merged rapidly-rotating stars like AB Dor, and which can also lead to the delayed ejection of one component of a multiple, as may have been observed in T Tau in 1998.

  19. Marine and Human Systems: Addressing Multiple Scales and Multiple Stressors

    NASA Astrophysics Data System (ADS)

    Hofmann, E. E.; Bundy, A.; Chuenpagdee, R.; Maddison, L.; Svendsen, E.

    2015-12-01

    The Integrated Marine Biogeochemistry and Ecosystem Research (IMBER) project aims to develop a comprehensive understanding of, and predictive capacity of ocean responses to accelerating global change and the consequent effects on the Earth System and human society. Understanding the changing ecology and biogeochemistry of marine ecosystems and their sensitivity and resilience to multiple drivers, pressures and stressors is critical to developing responses that will help reduce the vulnerability of marine-dependent human communities. The cumulative pressure of anthropogenic activities on marine systems is already apparent and is projected to increase in the next decades. Policy- and decision-makers need assessments of the status and trends of marine habitats, species, and ecosystems to promote sustainable human activities in the marine environment, particularly in light of global environmental change and changing social systems and human pressures. The IMBER community recently undertook a synthesis and evaluation of approaches for ecosystem-based marine governance, integrated modeling of marine social-ecological systems, and the social and ecological consequences of changing marine ecosystems. The outcomes of this activity provide assessments of current understanding, indicate approaches needed to predict the effects of multiple stressors, at multiple scales, on marine ecosystems and dependent human populations, and highlight approaches for developing innovative societal responses to changing marine ecosystems.

  20. Regions, systems, and the brain: hierarchical measures of functional integration in fMRI.

    PubMed

    Marrelec, Guillaume; Bellec, Pierre; Krainik, Alexandre; Duffau, Hugues; Pélégrini-Issac, Mélanie; Lehéricy, Stéphane; Benali, Habib; Doyon, Julien

    2008-08-01

    In neuroscience, the notion has emerged that the brain abides by two principles: segregation and integration. Segregation into functionally specialized systems and integration of information flow across systems are basic principles that are thought to shape the functional architecture of the brain. A measure called integration, originating from information theory and derived from mutual information, has been proposed to characterize the global integrative state of a network. In this paper, we show that integration can be applied in a hierarchical fashion to quantify functional interactions between compound systems, each system being composed of several regions. We apply this method to fMRI datasets from patients with low-grade glioma and show how it can efficiently extract information related to both intra- and interhemispheric reorganization induced by lesional brain plasticity.

  1. A proof-of-concept implementation of persistence in a hierarchical storage system

    NASA Technical Reports Server (NTRS)

    Grossman, Robert; Qin, Xiao; Lifka, Dave

    1992-01-01

    The concept of providing transparent access to a collection of files in a mass storage system is a familiar one. The goal of this project was to investigate the feasibility of providing similar access to a collection of persistent, complex objects. We describe an architecture for interfacing a persistent store of complex objects to a hierarchical storage system. Persistent object stores support the uniform creation, storage, and access of complex objects, regardless of their lifetimes. In other words, a mechanism is provided so that persistent objects outlive the processes which create them and can be accessed in a uniform manner by other processes. We validated this architecture by implementing a proof-of-concept system and testing the system on two stores of data. These tests indicate that this architecture supports the creation, storage, and access of very large persistent object stores.

  2. Hierarchical Ada robot programming system (HARPS)- A complete and working telerobot control system based on the NASREM model

    NASA Technical Reports Server (NTRS)

    Leake, Stephen; Green, Tom; Cofer, Sue; Sauerwein, Tim

    1989-01-01

    HARPS is a telerobot control system that can perform some simple but useful tasks. This capability is demonstrated by performing the ORU exchange demonstration. HARPS is based on NASREM (NASA Standard Reference Model). All software is developed in Ada, and the project incorporates a number of different CASE (computer-aided software engineering) tools. NASREM was found to be a valid and useful model for building a telerobot control system. Its hierarchical and distributed structure creates a natural and logical flow for implementing large complex robust control systems. The ability of Ada to create and enforce abstraction enhanced the implementation of such control systems.

  3. Minimax terminal approach problem in two-level hierarchical nonlinear discrete-time dynamical system

    SciTech Connect

    Shorikov, A. F.

    2015-11-30

    We consider a discrete–time dynamical system consisting of three controllable objects. The motions of all objects are given by the corresponding vector nonlinear or linear discrete–time recurrent vector relations, and control system for its has two levels: basic (first or I level) that is dominating and subordinate level (second or II level) and both have different criterions of functioning and united a priori by determined informational and control connections defined in advance. For the dynamical system in question, we propose a mathematical formalization in the form of solving a multistep problem of two-level hierarchical minimax program control over the terminal approach process with incomplete information and give a general scheme for its solving.

  4. Generic-type hierarchical multi digital signal processor system for hard-field tomography.

    PubMed

    Garcia Castillo, Sergio; Ozanyan, Krikor B

    2007-05-01

    This article introduces the design and implementation of a hierarchical multi digital signal processor system aimed to perform parallel multichannel measurements and data processing of the type widely used in hard-field tomography. Details are presented of a complete tomography system with modular and expandable architecture, capable of accommodating a variety of data processing modalities, configured by software. The configuration of the acquisition and processing circuits and the management of the data flow allow a data frame rate of up to 250 kHz. Results of a case study, guided path tomography for temperature mapping, are shown as a direct demonstration of the system's capabilities. Digital lock-in detection is employed for data processing to extract the information from ac measurements of the temperature-induced resistance changes in an array of 32 noninteracting transducers, which is further exported for visualization.

  5. Pre-main sequence multiple systems

    NASA Astrophysics Data System (ADS)

    Bouy, Hervé

    2011-04-01

    It is now well established that the majority of young stars are found in multiple systems, so that any theory of stellar formation must account for their existence and properties. Studying the properties of multiple star systems therefore represents a very powerful approach to place observational constraints on star formation theories. Additionally, multiple systems offer other advantages. They provide the most accurate and unambiguous way to measure masses, using orbital fitting and Kepler's laws, and even the stellar radius in the special case of eclipsing binaries. They also allow to compare the properties of 2 coeval objects with different masses, providing important tests for the evolutionary models.

  6. Hierarchal clustering yields insight into multidrug-resistant bacteria isolated from a cattle feedlot wastewater treatment system.

    PubMed

    Jahne, Michael A; Rogers, Shane W; Ramler, Ivan P; Holder, Edith; Hayes, Gina

    2015-01-01

    Forty-two percent of Escherichia coli and 58% of Enterococcus spp. isolated from cattle feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22% of E. coli and 37% of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant E. coli isolates that included cephalosporins (ceftiofur, cefoxitin, and ceftriaxone), aminoglycosides (gentamycin, kanamycin, and amikacin), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among vancomycin, linezolid, and daptomycin was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. Vancomycin resistance (n = 49) only occurred when isolates were resistant to linezolid, daptomycin, and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested (tylosin, erythromycin, lincomycin, and quinipristin/dalfopristin). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and oxazolidinones may result in resistance to vancomycin as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health.

  7. Hierarchal clustering yields insight into multidrug-resistant bacteria isolated from a cattle feedlot wastewater treatment system.

    PubMed

    Jahne, Michael A; Rogers, Shane W; Ramler, Ivan P; Holder, Edith; Hayes, Gina

    2015-01-01

    Forty-two percent of Escherichia coli and 58% of Enterococcus spp. isolated from cattle feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22% of E. coli and 37% of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant E. coli isolates that included cephalosporins (ceftiofur, cefoxitin, and ceftriaxone), aminoglycosides (gentamycin, kanamycin, and amikacin), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among vancomycin, linezolid, and daptomycin was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. Vancomycin resistance (n = 49) only occurred when isolates were resistant to linezolid, daptomycin, and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested (tylosin, erythromycin, lincomycin, and quinipristin/dalfopristin). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and oxazolidinones may result in resistance to vancomycin as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health. PMID:25504186

  8. A neurodynamical model of visual attention: feedback enhancement of spatial resolution in a hierarchical system.

    PubMed

    Deco, G; Zihl, J

    2001-01-01

    Human beings have the capacity to recognize objects in natural visual scenes with high efficiency despite the complexity of such scenes, which usually contain multiple objects. One possible mechanism for dealing with this problem is selective attention. Psychophysical evidence strongly suggests that selective attention can enhance the spatial resolution in the input region corresponding to the focus of attention. In this work we adopt a computational neuroscience perspective to analyze the attentional enhancement of spatial resolution in the area containing the objects of interest. We extend and apply the computational model of Deco and Schürmann (2000), which consists of several modules with feedforward and feedback interconnections describing the mutual links between different areas of the visual cortex. Each module analyses the visual input with different spatial resolution and can be thought of as a hierarchical predictor at a given level of resolution. Moreover, each hierarchical predictor has a submodule that consists of a group of neurons performing a biologically based 2D Gabor wavelet transformation at a given resolution level. The attention control decides in which local regions the spatial resolution should be enhanced in a serial fashion. In this sense, the scene is first analyzed at a coarse resolution level, and the focus of attention enhances iteratively the resolution at the location of an object until the object is identified. We propose and simulate new psychophysical experiments where the effect of the attentional enhancement of spatial resolution can be demonstrated by predicting different reaction time profiles in visual search experiments where the target and distractors are defined at different levels of resolution.

  9. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle.

    PubMed

    Peng, Jiankun; He, Hongwen; Liu, Wei; Guo, Hongqiang

    2015-01-01

    This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved. PMID:26236772

  10. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle

    PubMed Central

    Peng, Jiankun; He, Hongwen; Liu, Wei; Guo, Hongqiang

    2015-01-01

    This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved. PMID:26236772

  11. A hierarchical modeling approach for estimating national distributions of chemicals in public drinking water systems.

    PubMed

    Qian, Song S; Schulman, Andrew; Koplos, Jonathan; Kotros, Alison; Kellar, Penny

    2004-02-15

    Water quality studies often include the analytical challenge of incorporating censored data and quantifying error of estimation. Many analytical methods exist for estimating distribution parameters when censored data are present. This paper presents a Bayesian-based hierarchical model for estimating the national distribution of the mean concentrations of chemicals occurring in U.S. public drinking water systems using fluoride and thallium as examples. The data used are Safe Drinking Water Act compliance monitoring data (with a significant proportion of left-censored data). The model, which assumes log-normality, was evaluated using simulated data sets generated from a series of Weibull distributions to illustrate the robustness of the model. The hierarchical model is easily implemented using the Markov chain Monte Carlo simulation method. In addition, the Bayesian method is able to quantify the uncertainty in the estimated cumulative density function. The estimated fluoride and thallium national distributions are presented. Results from this study can be used to develop prior distributions for future U.S. drinking water regulatory studies of contaminant occurrence. PMID:14998034

  12. Self-assembly of hierarchically ordered structures in DNA nanotube systems

    NASA Astrophysics Data System (ADS)

    Glaser, Martin; Schnauß, Jörg; Tschirner, Teresa; Schmidt, B. U. Sebastian; Moebius-Winkler, Maximilian; Käs, Josef A.; Smith, David M.

    2016-05-01

    The self-assembly of molecular and macromolecular building blocks into organized patterns is a complex process found in diverse systems over a wide range of size and time scales. The formation of star- or aster-like configurations, for example, is a common characteristic in solutions of polymers or other molecules containing multi-scaled, hierarchical assembly processes. This is a recurring phenomenon in numerous pattern-forming systems ranging from cellular constructs to solutions of ferromagnetic colloids or synthetic plastics. To date, however, it has not been possible to systematically parameterize structural properties of the constituent components in order to study their influence on assembled states. Here, we circumvent this limitation by using DNA nanotubes with programmable mechanical properties as our basic building blocks. A small set of DNA oligonucleotides can be chosen to hybridize into micron-length DNA nanotubes with a well-defined circumference and stiffness. The self-assembly of these nanotubes to hierarchically ordered structures is driven by depletion forces caused by the presence of polyethylene glycol. This trait allowed us to investigate self-assembly effects while maintaining a complete decoupling of density, self-association or bundling strength, and stiffness of the nanotubes. Our findings show diverse ranges of emerging structures including heterogeneous networks, aster-like structures, and densely bundled needle-like structures, which compare to configurations found in many other systems. These show a strong dependence not only on concentration and bundling strength, but also on the underlying mechanical properties of the nanotubes. Similar network architectures to those caused by depletion forces in the low-density regime are obtained when an alternative hybridization-based bundling mechanism is employed to induce self-assembly in an isotropic network of pre-formed DNA nanotubes. This emphasizes the universal effect inevitable

  13. A Test of Stellar Cohabitation in Multiple Transiting Planet Systems

    NASA Astrophysics Data System (ADS)

    Morehead, Robert C.; Ford, E. B.

    2013-01-01

    The Kepler mission has discovered over 2,300 exoplanet candidates, including more than 885 associated with target stars with multiple transiting planet candidates. While these putative multiple planet systems are predicted to have an extremely low false positive rate, it is important to test what fraction are indeed transiting a single star and what fraction are some sort of blend (e.g., one transiting planet and an eclipsing binary, or two planet-hosting stars blended within the photometric aperture). We perform such a test for stellar cohabitation using the observed distribution of ξ, the period-normalized transit duration ratio of pairs of transiting planet candidates. We developed a Bayesian framework to estimate the probability that two candidates orbit the target star based on the observed orbital periods and light curve properties with an emphasis on ξ. For priors distributions, we use empirical planet, binary star, and hierarchical triple star occurrence rates and galactic population synthesis models. Using Monte Carlo simulations, we calculate the implied distributions of ξ for all plausible blend scenarios; i.e., a planet around the target star and a background or physically associated eclipsing binary star, a planet around the the target star and a planet around a background or physically associated secondary star, as well as a single star with two planets and no blend. Finally, we compute the posterior probability that a given pair of transiting planet candidates are indeed a pair of planets in orbit around the target star given the observed values. We present the results of our test for a selection Kepler multiple planet candidates and for systems confirmed through other methods, such as transit timing variations. We demonstrate the utility of this technique for the confirmation and characterization of multiple transiting planet systems.

  14. Genetics Home Reference: multiple system atrophy

    MedlinePlus

    ... OPCA progressive autonomic failure with multiple system atrophy SDS Shy-Drager syndrome sporadic olivopontocerebellar atrophy Related Information ... A, Hulot JS, Morrison KE, Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, ...

  15. Multiple microprocessor systems: what, why, and when

    SciTech Connect

    Fathi, E.T.; Krieger, M.

    1983-03-01

    For many applications-especially those requiring diversified computations in real time or high reliability without massive redundancy-multiple micons-especially those requiring diversified computations in real time or high reliability without massive redundancy-multiple microprocessor systems are the logical choice. Multiple microprocessor systems can provide an appropriate solution to the demand for additional computing power to meet new requirements and to support complex applications. To clarify the concept and its associated terminology, this article considers the what, why, and when of multiple microprocessor systems. Aspects that apply to all processors, regardless of size, are presented in general terms. However, since the main interest lies with microprocessor-based systems, aspects that depend on processor power and input/output flexibility are related specifically to microprocessors. 38 references.

  16. Distributed Hierarchical Control Architecture for Transient Dynamics Improvement in Power Systems

    SciTech Connect

    Marinovici, Laurentiu D.; Lian, Jianming; Kalsi, Karanjit; Du, Pengwei; Elizondo, Marcelo A.

    2013-08-24

    In this paper, a novel distributed hierarchical coordinated control architecture is proposed for large scale power systems. The newly considered architecture facilitates frequency restoration and power balancing functions to be decoupled and implemented at different levels. At the local level, decentralized robust generator controllers are designed to quickly restore frequency after large faults and disturbances in the system. The controllers presented herein are shown to improve transient stability performance, as compared to conventional governor and excitation control. At the area level, Automatic Generation Control (AGC) is modified and coordinates with the decentralized robust controllers to reach the interchange schedule in the tie lines. The interaction of local and zonal controllers is validated through detailed simulations.

  17. A Framework for a Decision Support System in a Hierarchical Extended Enterprise Decision Context

    NASA Astrophysics Data System (ADS)

    Boza, Andrés; Ortiz, Angel; Vicens, Eduardo; Poler, Raul

    Decision Support System (DSS) tools provide useful information to decision makers. In an Extended Enterprise, a new goal, changes in the current objectives or small changes in the extended enterprise configuration produce a necessary adjustment in its decision system. A DSS in this context must be flexible and agile to make suitable an easy and quickly adaptation to this new context. This paper proposes to extend the Hierarchical Production Planning (HPP) structure to an Extended Enterprise decision making context. In this way, a framework for DSS in Extended Enterprise context is defined using components of HPP. Interoperability details have been reviewed to identify the impact in this framework. The proposed framework allows overcoming some interoperability barriers, identifying and organizing components for a DSS in Extended Enterprise context, and working in the definition of an architecture to be used in the design process of a flexible DSS in Extended Enterprise context which can reuse components for futures Extended Enterprise configurations.

  18. Photo-driven autonomous hydrogen generation system based on hierarchically shelled ZnO nanostructures

    SciTech Connect

    Kim, Heejin; Yong, Kijung

    2013-11-25

    A quantum dot semiconductor sensitized hierarchically shelled one-dimensional ZnO nanostructure has been applied as a quasi-artificial leaf for hydrogen generation. The optimized ZnO nanostructure consists of one dimensional nanowire as a core and two-dimensional nanosheet on the nanowire surface. Furthermore, the quantum dot semiconductors deposited on the ZnO nanostructures provide visible light harvesting properties. To realize the artificial leaf, we applied the ZnO based nanostructure as a photoelectrode with non-wired Z-scheme system. The demonstrated un-assisted photoelectrochemical system showed the hydrogen generation properties under 1 sun condition irradiation. In addition, the quantum dot modified photoelectrode showed 2 mA/cm{sup 2} current density at the un-assisted condition.

  19. Resilient control of cyber-physical systems against intelligent attacker: a hierarchal stackelberg game approach

    NASA Astrophysics Data System (ADS)

    Yuan, Yuan; Sun, Fuchun; Liu, Huaping

    2016-07-01

    This paper is concerned with the resilient control under denial-of-service attack launched by the intelligent attacker. The resilient control system is modelled as a multi-stage hierarchical game with a corresponding hierarchy of decisions made at cyber and physical layer, respectively. Specifically, the interaction in the cyber layer between different security agents is modelled as a static infinite Stackelberg game, while in the underlying physical layer the full-information H∞ minimax control with package drops is modelled as a different Stackelberg game. Both games are solved sequentially, which is consistent with the actual situations. Finally, the proposed method is applied to the load frequency control of the power system, which demonstrates its effectiveness.

  20. Planet formation in multiple stellar systems: GG Tau A

    NASA Astrophysics Data System (ADS)

    Di Folco, E.; Dutrey, A.; Guilloteau, S.; Le Bouquin, J.-B.; Lacour, S.; Berger, J.-P.; Köhler, R.; Piétu, V.

    2014-12-01

    GG Tau is a hierarchical quadruple system of young, low-mass stars. Because of its well-studied bright circumbinary ring of dust and gas surrounding the main binary GG Tau A, it is a unique laboratory to study planet formation in the disturbed environment of binary/multiple stellar systems. We have started a large observing program of GG Tau A that combines several high-resolution instruments in a multi-wavelength approach. We have recently reported the detection of a new low-mass companion in GG Tau A that turns out to itself be a triple system. This discovery was possible thanks to the very high angular resolution of the near-IR instrument PIONIER on the VLT interferometer, and was confirmed with sub-aperture masking techniques on VLT/NaCo. The detected close binary GG Tau Ab (ρ = 0.032'', or about 5 AU) provides a natural explanation for two enigmas: the discrepancy between the dynamical mass and the spectral type estimates in GG Tau A, and the absence of dust thermal emission in the vicinity of the Ab component. GRAVITY will provide the adequate angular resolution to complete the astrometric characterization of the close binary in the next 10 years. With now 5 coeval low-mass stars, GG Tau is an ideal laboratory to calibrate stellar evolution tracks at young ages (few Myr). Beyond this peculiar system, GRAVITY also has a strong potential to study the impact of multiplicity on the existence of disks, and in fine on planet formation mechanisms in multiple systems.

  1. Inventory and Billing Systems for Multiple Users.

    ERIC Educational Resources Information Center

    Frazier, Lavon

    Washington State University developed a comprehensive supplies inventory system and a generalized billing system with multiple users in mind. The supplies inventory control system developed for Central Stores, a self-sustaining service center that purchases and warehouses office, laboratory, and hardware supplies, was called AIMS, An Inventory…

  2. Hand-held multiple system gas chromatograph

    DOEpatents

    Yu, Conrad M.

    2001-01-01

    A multiple parallel hand-held gas chromatograph (GC) system which includes several independent GCs. Each independent GC has its own injector, separation column, detector and oven and the GCs are mounted in a light weight hand-held assembly. Each GC operates independently and simultaneously. Because of different coatings in different separation columns, different retention times for the same gas will be measured. Thus, for a GC system with multiple parallel GCs, the system can measure, in a short period, different retention times and provide a cross-reference in the determination of the measured gas and to become a two-dimensional system for direct field use.

  3. Biological Chitin-MOF Composites with Hierarchical Pore Systems for Air-Filtration Applications.

    PubMed

    Wisser, Dorothea; Wisser, Florian M; Raschke, Silvia; Klein, Nicole; Leistner, Matthias; Grothe, Julia; Brunner, Eike; Kaskel, Stefan

    2015-10-19

    Metal-organic frameworks (MOFs) are promising materials for gas-separation and air-filtration applications. However, for these applications, MOF crystallites need to be incorporated in robust and manageable support materials. We used chitin-based networks from a marine sponge as a non-toxic, biodegradable, and low-weight support material for MOF deposition. The structural properties of the material favor predominant nucleation of the MOF crystallites at the inside of the hollow fibers. This composite has a hierarchical pore system with surface areas up to 800 m(2)  g(-1) and pore volumes of 3.6 cm(3)  g(-1) , allowing good transport kinetics and a very high loading of the active material. Ammonia break-through experiments highlight the accessibility of the MOF crystallites and the adsorption potential of the composite indicating their high potential for filtration applications for toxic industrial gases.

  4. Secular dynamics in hierarchical three-body systems with mass loss and mass transfer

    SciTech Connect

    Michaely, Erez; Perets, Hagai B.

    2014-10-20

    Recent studies have shown that secular evolution of triple systems can play a major role in the evolution and interaction of their inner binaries. Very few studies explored the stellar evolution of triple systems, and in particular the mass-loss phase of the evolving stellar components. Here we study the dynamical secular evolution of hierarchical triple systems undergoing mass loss. We use the secular evolution equations and include the effects of mass loss and mass transfer, as well as general relativistic effects. We present various evolutionary channels taking place in such evolving triples, and discuss both the effects of mass loss and mass transfer in the inner binary system, as well as the effects of mass loss/transfer from an outer third companion. We discuss several distinct types/regimes of triple secular evolution, where the specific behavior of a triple system can sensitively depend on its hierarchy and the relative importance of classical and general relativistic effects. We show that the orbital changes due to mass-loss and/or mass-transfer processes can effectively transfer a triple system from one dynamical regime to another. In particular, mass loss/transfer can both induce and quench high-amplitude (Lidov-Kozai) variations in the eccentricity and inclination of the inner binaries of evolving triples. They can also change the system dynamics from an orderly periodic behavior to a chaotic one, and vice versa.

  5. Kramers' rate for systems with multiplicative noise.

    PubMed

    Rosas, Alexandre; Pinto, Italo'Ivo Lima Dias; Lindenberg, Katja

    2016-07-01

    Kramers' rate for the passage of trajectories X(t) over an energy barrier due to thermal or other fluctuations is usually associated with additive noise. We present a generalization of Kramers' rate for systems with multiplicative noise. We show that the expression commonly used in the literature for multiplicative noise is not correct, and we present results of numerical integrations of the Langevin equation for dX(t)/dt evolving in a quartic bistable potential which corroborate our claim. PMID:27575071

  6. Kramers' rate for systems with multiplicative noise

    NASA Astrophysics Data System (ADS)

    Rosas, Alexandre; Pinto, Italo'Ivo Lima Dias; Lindenberg, Katja

    2016-07-01

    Kramers' rate for the passage of trajectories X (t ) over an energy barrier due to thermal or other fluctuations is usually associated with additive noise. We present a generalization of Kramers' rate for systems with multiplicative noise. We show that the expression commonly used in the literature for multiplicative noise is not correct, and we present results of numerical integrations of the Langevin equation for d X (t )/d t evolving in a quartic bistable potential which corroborate our claim.

  7. Application of Bayesian inference to the study of hierarchical organization in self-organized complex adaptive systems

    NASA Astrophysics Data System (ADS)

    Knuth, K. H.

    2001-05-01

    We consider the application of Bayesian inference to the study of self-organized structures in complex adaptive systems. In particular, we examine the distribution of elements, agents, or processes in systems dominated by hierarchical structure. We demonstrate that results obtained by Caianiello [1] on Hierarchical Modular Systems (HMS) can be found by applying Jaynes' Principle of Group Invariance [2] to a few key assumptions about our knowledge of hierarchical organization. Subsequent application of the Principle of Maximum Entropy allows inferences to be made about specific systems. The utility of the Bayesian method is considered by examining both successes and failures of the hierarchical model. We discuss how Caianiello's original statements suffer from the Mind Projection Fallacy [3] and we restate his assumptions thus widening the applicability of the HMS model. The relationship between inference and statistical physics, described by Jaynes [4], is reiterated with the expectation that this realization will aid the field of complex systems research by moving away from often inappropriate direct application of statistical mechanics to a more encompassing inferential methodology.

  8. Insensitivity of the human sentence-processing system to hierarchical structure.

    PubMed

    Frank, Stefan L; Bod, Rens

    2011-06-01

    Although it is generally accepted that hierarchical phrase structures are instrumental in describing human language, their role in cognitive processing is still debated. We investigated the role of hierarchical structure in sentence processing by implementing a range of probabilistic language models, some of which depended on hierarchical structure, and others of which relied on sequential structure only. All models estimated the occurrence probabilities of syntactic categories in sentences for which reading-time data were available. Relating the models' probability estimates to the data showed that the hierarchical-structure models did not account for variance in reading times over and above the amount of variance accounted for by all of the sequential-structure models. This suggests that a sentence's hierarchical structure, unlike many other sources of information, does not noticeably affect the generation of expectations about upcoming words.

  9. Graph-theoretic quantum system modelling for neuronal microtubules as hierarchical clustered quantum Hopfield networks

    NASA Astrophysics Data System (ADS)

    Srivastava, D. P.; Sahni, V.; Satsangi, P. S.

    2014-08-01

    Graph-theoretic quantum system modelling (GTQSM) is facilitated by considering the fundamental unit of quantum computation and information, viz. a quantum bit or qubit as a basic building block. Unit directional vectors "ket 0" and "ket 1" constitute two distinct fundamental quantum across variable orthonormal basis vectors, for the Hilbert space, specifying the direction of propagation of information, or computation data, while complementary fundamental quantum through, or flow rate, variables specify probability parameters, or amplitudes, as surrogates for scalar quantum information measure (von Neumann entropy). This paper applies GTQSM in continuum of protein heterodimer tubulin molecules of self-assembling polymers, viz. microtubules in the brain as a holistic system of interacting components representing hierarchical clustered quantum Hopfield network, hQHN, of networks. The quantum input/output ports of the constituent elemental interaction components, or processes, of tunnelling interactions and Coulombic bidirectional interactions are in cascade and parallel interconnections with each other, while the classical output ports of all elemental components are interconnected in parallel to accumulate micro-energy functions generated in the system as Hamiltonian, or Lyapunov, energy function. The paper presents an insight, otherwise difficult to gain, for the complex system of systems represented by clustered quantum Hopfield network, hQHN, through the application of GTQSM construct.

  10. Satellite multiple access systems for mobile communication

    NASA Technical Reports Server (NTRS)

    Lewis, J. L.

    1979-01-01

    This paper considers multiple access techniques for a mobile radio system which incorporates a geosynchronous orbiting satellite repeater through which mobile terminals communicate. The communication capacities of FDMA, TDMA and CDMA systems are examined for a 4 MHz bandwidth system to serve up to 10,000 users. An FDMA system with multibeam coverage is analyzed in detail. The system includes an order-wire network for demand-access control and reassignment of satellite channels. Satellite and terminal configurations are developed to a block diagram level and system costs and implementation requirements are discussed.

  11. Multiple System Atrophy with Orthostatic Hypotension (Shy-Drager Syndrome)

    MedlinePlus

    ... Enhancing Diversity Find People About NINDS NINDS Multiple System Atrophy with Orthostatic Hypotension Information Page Synonym(s): Shy- ... being done? Clinical Trials Organizations What is Multiple System Atrophy with Orthostatic Hypotension? Multiple system atrophy with ...

  12. Hierarchical Auxetic Mechanical Metamaterials

    PubMed Central

    Gatt, Ruben; Mizzi, Luke; Azzopardi, Joseph I.; Azzopardi, Keith M.; Attard, Daphne; Casha, Aaron; Briffa, Joseph; Grima, Joseph N.

    2015-01-01

    Auxetic mechanical metamaterials are engineered systems that exhibit the unusual macroscopic property of a negative Poisson's ratio due to sub-unit structure rather than chemical composition. Although their unique behaviour makes them superior to conventional materials in many practical applications, they are limited in availability. Here, we propose a new class of hierarchical auxetics based on the rotating rigid units mechanism. These systems retain the enhanced properties from having a negative Poisson's ratio with the added benefits of being a hierarchical system. Using simulations on typical hierarchical multi-level rotating squares, we show that, through design, one can control the extent of auxeticity, degree of aperture and size of the different pores in the system. This makes the system more versatile than similar non-hierarchical ones, making them promising candidates for industrial and biomedical applications, such as stents and skin grafts. PMID:25670400

  13. Multiple robot system for decentralized SLAM investigations

    NASA Astrophysics Data System (ADS)

    Deaves, Rob H.; Nicholson, David; Gough, David W.; Binns, Lewis A.; Vangasse, Paul; Greenway, Phil

    2000-10-01

    Technical details of laboratory based robotic system for researching decentralized Simultaneous Localization and Map building (SLAM) are provided. The main components of the system are Pioneer (ActivMedia) robots, laboratory environment for mapping, laser tracking system for testing the SLAM accuracy and a suite of SLAM software algorithms. The system is used to provide a demonstration and initial practical results of decentralized multiple-platform SLAM. The paper concludes that useful system has been set-up for researching this technology area. Further, the demonstration highlights important benefits of multiple- platform decentralized SLAM over a single platform approach. These include an increase in map accuracy, an improvement in the completeness and timeliness of the map, and an increase in platform accuracy although that platform was not extrinsically sensed. Future research areas are discussed.

  14. Multiple Fault Isolation in Redundant Systems

    NASA Technical Reports Server (NTRS)

    Pattipati, Krishna R.; Patterson-Hine, Ann; Iverson, David

    1997-01-01

    Fault diagnosis in large-scale systems that are products of modern technology present formidable challenges to manufacturers and users. This is due to large number of failure sources in such systems and the need to quickly isolate and rectify failures with minimal down time. In addition, for fault-tolerant systems and systems with infrequent opportunity for maintenance (e.g., Hubble telescope, space station), the assumption of at most a single fault in the system is unrealistic. In this project, we have developed novel block and sequential diagnostic strategies to isolate multiple faults in the shortest possible time without making the unrealistic single fault assumption.

  15. Multiple Fault Isolation in Redundant Systems

    NASA Technical Reports Server (NTRS)

    Pattipati, Krishna R.

    1997-01-01

    Fault diagnosis in large-scale systems that are products of modem technology present formidable challenges to manufacturers and users. This is due to large number of failure sources in such systems and the need to quickly isolate and rectify failures with minimal down time. In addition, for fault-tolerant systems and systems with infrequent opportunity for maintenance (e.g., Hubble telescope, space station), the assumption of at most a single fault in the system is unrealistic. In this project, we have developed novel block and sequential diagnostic strategies to isolate multiple faults in the shortest possible time without making the unrealistic single fault assumption.

  16. Eccentricity growth and orbit flip in near-coplanar hierarchical three-body systems

    SciTech Connect

    Li, Gongjie; Naoz, Smadar; Kocsis, Bence; Loeb, Abraham

    2014-04-20

    The secular dynamical evolution of a hierarchical three-body system in which a distant third object orbits around a binary has been studied extensively, demonstrating that the inner orbit can undergo large eccentricity and inclination oscillations. It was shown before that starting with a circular inner orbit, large mutual inclination (40°-140°) can produce long timescale modulations that drive the eccentricity to extremely large values and can flip the orbit. Here, we demonstrate that starting with an almost coplanar configuration, for eccentric inner and outer orbits, the eccentricity of the inner orbit can still be excited to high values, and the orbit can flip by ∼180°, rolling over its major axis. The ∼180° flip criterion and the flip timescale are described by simple analytic expressions that depend on the initial orbital parameters. With tidal dissipation, this mechanism can produce counter-orbiting exoplanetary systems. In addition, we also show that this mechanism has the potential to enhance the tidal disruption or collision rates for different systems. Furthermore, we explore the entire e {sub 1} and i {sub 0} parameter space that can produce flips.

  17. Stickiness in Hamiltonian systems: from sharply divided to hierarchical phase space.

    PubMed

    Altmann, Eduardo G; Motter, Adilson E; Kantz, Holger

    2006-02-01

    We investigate the dynamics of chaotic trajectories in simple yet physically important Hamiltonian systems with nonhierarchical borders between regular and chaotic regions with positive measures. We show that the stickiness to the border of the regular regions in systems with such a sharply divided phase space occurs through one-parameter families of marginally unstable periodic orbits and is characterized by an exponent gamma=2 for the asymptotic power-law decay of the distribution of recurrence times. Generic perturbations lead to systems with hierarchical phase space, where the stickiness is apparently enhanced due to the presence of infinitely many regular islands and Cantori. In this case, we show that the distribution of recurrence times can be composed of a sum of exponentials or a sum of power laws, depending on the relative contribution of the primary and secondary structures of the hierarchy. Numerical verification of our main results are provided for area-preserving maps, mushroom billiards, and the newly defined magnetic mushroom billiards. PMID:16605429

  18. A high performance hierarchical storage management system for the Canadian tier-1 centre at TRIUMF

    NASA Astrophysics Data System (ADS)

    Deatrich, D. C.; Liu, S. X.; Tafirout, R.

    2010-04-01

    We describe in this paper the design and implementation of Tapeguy, a high performance non-proprietary Hierarchical Storage Management (HSM) system which is interfaced to dCache for efficient tertiary storage operations. The system has been successfully implemented at the Canadian Tier-1 Centre at TRIUMF. The ATLAS experiment will collect a large amount of data (approximately 3.5 Petabytes each year). An efficient HSM system will play a crucial role in the success of the ATLAS Computing Model which is driven by intensive large-scale data analysis activities that will be performed on the Worldwide LHC Computing Grid infrastructure continuously. Tapeguy is Perl-based. It controls and manages data and tape libraries. Its architecture is scalable and includes Dataset Writing control, a Read-back Queuing mechanism and I/O tape drive load balancing as well as on-demand allocation of resources. A central MySQL database records metadata information for every file and transaction (for audit and performance evaluation), as well as an inventory of library elements. Tapeguy Dataset Writing was implemented to group files which are close in time and of similar type. Optional dataset path control dynamically allocates tape families and assign tapes to it. Tape flushing is based on various strategies: time, threshold or external callbacks mechanisms. Tapeguy Read-back Queuing reorders all read requests by using an elevator algorithm, avoiding unnecessary tape loading and unloading. Implementation of priorities will guarantee file delivery to all clients in a timely manner.

  19. Multiple Intelligences Theory in Turkish Education System

    ERIC Educational Resources Information Center

    Kaya, Osman Nafiz

    2006-01-01

    Turkey can be regarded as a cultural bridge between the East and the West. After Turkish Republic was established by Ataturk in 1923, many radical revolutions, including the Turkish Education System, were made in order for Turkey to reach the level of contemporary civilizations. In the last two decades, Multiple Intelligences (MI) theory has been…

  20. Orbits of Four Young Triple-lined Multiple Systems

    NASA Astrophysics Data System (ADS)

    Tokovinin, Andrei

    2016-07-01

    Each of the nearby triple systems HIP 7601, 13498, 23824, and 113597 (HD 10800, 18198, 35877, 217379) consist of solar-type dwarfs with comparable masses, where all three components are resolved spectrally, while the outer pairs are resolved both visually and spectrally. These stars are relatively young (between 100 and 600 Myr) and chromospherically active (X-ray sources), although they rotate slowly. I determine the spectroscopic orbits of the inner subsystems (periods 19.4, 14.1, 5.6, 20.3 days) and the orbits of the outer systems (periods 1.75, 51, 27, 500 years, respectively). For HIP 7601 and 13498, the combined spectro-interferometric outer orbits produce direct measurement of the masses of all of the components, allowing for a comparison with stellar models. The 6708 Å lithium line is present and its strength is measured in each component individually by subtracting the contributions of the other components. The inner and outer orbits of HIP 7601 are nearly circular, likely co-planar, and have a modest period ratio of 1:33. This study contributes to the characterization of hierarchical multiplicity in the solar neighborhood and provides data for testing stellar evolutionary models and chronology.

  1. Secular dynamics of hierarchical quadruple systems: the case of a triple system orbited by a fourth body

    NASA Astrophysics Data System (ADS)

    Hamers, Adrian S.; Perets, Hagai B.; Antonini, Fabio; Portegies Zwart, Simon F.

    2015-06-01

    We study the secular gravitational dynamics of quadruple systems consisting of a hierarchical triple system orbited by a fourth body. These systems can be decomposed into three binary systems with increasing semimajor axes, binaries A, B and C. The Hamiltonian of the system is expanded in ratios of the three binary separations, and orbit averaged. Subsequently, we numerically solve the equations of motion. We study highly hierarchical systems that are well described by the lowest order terms in the Hamiltonian. We find that the qualitative behaviour is determined by the ratio {R}_0 of the initial Kozai-Lidov (KL) time-scales of the binary pairs AB and BC. If {R}_0≪ 1, binaries AB remain coplanar if this is initially the case, and KL eccentricity oscillations in binary B are efficiently quenched. If {R}_0≫ 1, binaries AB become inclined, even if initially coplanar. However, there are no induced KL eccentricity oscillations in binary A. Lastly, if {R}_0˜ 1, complex KL eccentricity oscillations can occur in binary A that are coupled with the KL eccentricity oscillations in B. Even if binaries A and B are initially coplanar, the induced inclination can result in very high eccentricity oscillations in binary A. These extreme eccentricities could have significant implications for strong interactions such as tidal interactions, gravitational wave dissipation, and collisions and mergers of stars and compact objects. As an example, we apply our results to a planet+moon system orbiting a central star, which in turn is orbited by a distant and inclined stellar companion or planet, and to observed stellar quadruples.

  2. Stress Effects on Multiple Memory System Interactions

    PubMed Central

    Ness, Deborah; Calabrese, Pasquale

    2016-01-01

    Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory systems, we review recent animal and human studies exploring the effects of stress on multiple memory systems. Apart from discussing the interaction between distinct memory systems in stressful situations, we will also outline the fundamental role of the amygdala in mediating such stress effects. Additionally, based on the methods applied in the herein discussed studies, we will discuss how memory translates into behaviour. PMID:27034845

  3. RESONANT POST-NEWTONIAN ECCENTRICITY EXCITATION IN HIERARCHICAL THREE-BODY SYSTEMS

    SciTech Connect

    Naoz, Smadar; Kocsis, Bence; Loeb, Abraham; Yunes, Nicolas

    2013-08-20

    We study the secular, hierarchical three-body problem to first-order in a post-Newtonian expansion of general relativity (GR). We expand the first-order post-Newtonian Hamiltonian to leading-order in the ratio of the semi-major axis of the two orbits. In addition to the well-known terms that correspond to the GR precession of the inner and outer orbits, we find a new secular post-Newtonian interaction term that can affect the long-term evolution of the triple. We explore the parameter space for highly inclined and eccentric systems, where the Kozai-Lidov mechanism can produce large-amplitude oscillations in the eccentricities. The standard lore, i.e., that GR effects suppress eccentricity, is only consistent with the parts of phase space where the GR timescales are several orders of magnitude shorter than the secular Newtonian one. In other parts of phase space, however, post-Newtonian corrections combined with the three-body ones can excite eccentricities. In particular, for systems where the GR timescale is comparable to the secular Newtonian timescales, the three-body interactions give rise to a resonant-like eccentricity excitation. Furthermore, for triples with a comparable-mass inner binary, where the eccentric Kozai-Lidov mechanism is suppressed, post-Newtonian corrections can further increase the eccentricity and lead to orbital flips even when the timescale of the former is much longer than the timescale of the secular Kozai-Lidov quadrupole perturbations.

  4. Formation of Black Hole Low-mass X-Ray Binaries in Hierarchical Triple Systems

    NASA Astrophysics Data System (ADS)

    Naoz, Smadar; Fragos, Tassos; Geller, Aaron; Stephan, Alexander P.; Rasio, Frederic A.

    2016-05-01

    The formation of black hole (BH) low-mass X-ray binaries (LMXB) poses a theoretical challenge, as low-mass companions are not expected to survive the common-envelope scenario with the BH progenitor. Here we propose a formation mechanism that skips the common-envelope scenario and relies on triple-body dynamics. We study the evolution of hierarchical triples following the secular dynamical evolution up to the octupole-level of approximation, including general relativity, tidal effects, and post-main-sequence evolution such as mass loss, changes to stellar radii, and supernovae. During the dynamical evolution of the triple system the “eccentric Kozai-Lidov” mechanism can cause large eccentricity excitations in the LMXB progenitor, resulting in three main BH-LMXB formation channels. Here we define BH-LMXB candidates as systems where the inner BH-companion star crosses its Roche limit. In the “eccentric” channel (˜81% of the LMXBs in our simulations) the donor star crosses its Roche limit during an extreme eccentricity excitation while still on a wide orbit. Second, we find a “giant” LMXB channel (˜11%), where a system undergoes only moderate eccentricity excitations but the donor star fills its Roche-lobe after evolving toward the giant branch. Third, we identify a “classical” channel (˜8%), where tidal forces and magnetic braking shrink and circularize the orbit to short periods, triggering mass-transfer. Finally, for the giant channel we predict an eccentric (˜0.3-0.6) preferably inclined (˜40°, ˜140°) tertiary, typically on a wide enough orbit (˜104 au) to potentially become unbound later in the triple evolution. While this initial study considers only one representative system and neglects BH natal kicks, we expect our scenario to apply across a broad region of parameter space for triple-star systems.

  5. An effective and secure key-management scheme for hierarchical access control in E-medicine system.

    PubMed

    Odelu, Vanga; Das, Ashok Kumar; Goswami, Adrijit

    2013-04-01

    Recently several hierarchical access control schemes are proposed in the literature to provide security of e-medicine systems. However, most of them are either insecure against 'man-in-the-middle attack' or they require high storage and computational overheads. Wu and Chen proposed a key management method to solve dynamic access control problems in a user hierarchy based on hybrid cryptosystem. Though their scheme improves computational efficiency over Nikooghadam et al.'s approach, it suffers from large storage space for public parameters in public domain and computational inefficiency due to costly elliptic curve point multiplication. Recently, Nikooghadam and Zakerolhosseini showed that Wu-Chen's scheme is vulnerable to man-in-the-middle attack. In order to remedy this security weakness in Wu-Chen's scheme, they proposed a secure scheme which is again based on ECC (elliptic curve cryptography) and efficient one-way hash function. However, their scheme incurs huge computational cost for providing verification of public information in the public domain as their scheme uses ECC digital signature which is costly when compared to symmetric-key cryptosystem. In this paper, we propose an effective access control scheme in user hierarchy which is only based on symmetric-key cryptosystem and efficient one-way hash function. We show that our scheme reduces significantly the storage space for both public and private domains, and computational complexity when compared to Wu-Chen's scheme, Nikooghadam-Zakerolhosseini's scheme, and other related schemes. Through the informal and formal security analysis, we further show that our scheme is secure against different attacks and also man-in-the-middle attack. Moreover, dynamic access control problems in our scheme are also solved efficiently compared to other related schemes, making our scheme is much suitable for practical applications of e-medicine systems.

  6. An effective and secure key-management scheme for hierarchical access control in E-medicine system.

    PubMed

    Odelu, Vanga; Das, Ashok Kumar; Goswami, Adrijit

    2013-04-01

    Recently several hierarchical access control schemes are proposed in the literature to provide security of e-medicine systems. However, most of them are either insecure against 'man-in-the-middle attack' or they require high storage and computational overheads. Wu and Chen proposed a key management method to solve dynamic access control problems in a user hierarchy based on hybrid cryptosystem. Though their scheme improves computational efficiency over Nikooghadam et al.'s approach, it suffers from large storage space for public parameters in public domain and computational inefficiency due to costly elliptic curve point multiplication. Recently, Nikooghadam and Zakerolhosseini showed that Wu-Chen's scheme is vulnerable to man-in-the-middle attack. In order to remedy this security weakness in Wu-Chen's scheme, they proposed a secure scheme which is again based on ECC (elliptic curve cryptography) and efficient one-way hash function. However, their scheme incurs huge computational cost for providing verification of public information in the public domain as their scheme uses ECC digital signature which is costly when compared to symmetric-key cryptosystem. In this paper, we propose an effective access control scheme in user hierarchy which is only based on symmetric-key cryptosystem and efficient one-way hash function. We show that our scheme reduces significantly the storage space for both public and private domains, and computational complexity when compared to Wu-Chen's scheme, Nikooghadam-Zakerolhosseini's scheme, and other related schemes. Through the informal and formal security analysis, we further show that our scheme is secure against different attacks and also man-in-the-middle attack. Moreover, dynamic access control problems in our scheme are also solved efficiently compared to other related schemes, making our scheme is much suitable for practical applications of e-medicine systems. PMID:23392626

  7. Multiple memory systems, development and conditioning.

    PubMed

    Stanton, M E

    2000-06-01

    A century of behavioral and neurobiological research suggests that Pavlovian conditioning involves three component memory systems: sensorimotor, affective and cognitive. In classical eyeblink conditioning, there is evidence that these three memory systems involve, respectively, the cerebellum, amygdala and hippocampus. This article reviews developmental research on eyeblink conditioning in rodents that is beginning to characterize ontogenetic dissociations and interactions among these memory systems. This research shows that the functional development of the affective system (conditioned fear response) precedes that of the sensorimotor system (conditioned eyeblink reflex). Modulation of these two systems by cognitive processes also seems to emerge at different points in ontogeny. Implications for cognitive development and research on multiple memory systems are discussed.

  8. Synchronization of chaotic systems and identification of nonlinear systems by using recurrent hierarchical type-2 fuzzy neural networks.

    PubMed

    Mohammadzadeh, Ardashir; Ghaemi, Sehraneh

    2015-09-01

    This paper proposes a novel approach for training of proposed recurrent hierarchical interval type-2 fuzzy neural networks (RHT2FNN) based on the square-root cubature Kalman filters (SCKF). The SCKF algorithm is used to adjust the premise part of the type-2 FNN and the weights of defuzzification and the feedback weights. The recurrence property in the proposed network is the output feeding of each membership function to itself. The proposed RHT2FNN is employed in the sliding mode control scheme for the synchronization of chaotic systems. Unknown functions in the sliding mode control approach are estimated by RHT2FNN. Another application of the proposed RHT2FNN is the identification of dynamic nonlinear systems. The effectiveness of the proposed network and its learning algorithm is verified by several simulation examples. Furthermore, the universal approximation of RHT2FNNs is also shown.

  9. MPACT Fast Neutron Multiplicity System Prototype Development

    SciTech Connect

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  10. MODEM: a multi-agent hierarchical structure to model the human motor control system.

    PubMed

    Emadi Andani, Mehran; Bahrami, Fariba; Jabehdar Maralani, Parviz; Ijspeert, Auke Jan

    2009-12-01

    In this study, based on behavioral and neurophysiological facts, a new hierarchical multi-agent architecture is proposed to model the human motor control system. Performance of the proposed structure is investigated by simulating the control of sit to stand movement. To develop the model, concepts of mixture of experts, modular structure, and some aspects of equilibrium point hypothesis were brought together. We have called this architecture MODularized Experts Model (MODEM). Human motor system is modeled at the joint torque level and the role of the muscles has been embedded in the function of the joint compliance characteristics. The input to the motor system, i.e., the central command, is the reciprocal command. At the lower level, there are several experts to generate the central command to control the task according to the details of the movement. The number of experts depends on the task to be performed. At the higher level, a "gate selector" block selects the suitable subordinate expert considering the context of the task. Each expert consists of a main controller and a predictor as well as several auxiliary modules. The main controller of an expert learns to control the performance of a given task by generating appropriate central commands under given conditions and/or constraints. The auxiliary modules of this expert learn to scrutinize the generated central command by the main controller. Auxiliary modules increase their intervention to correct the central command if the movement error is increased due to an external disturbance. Each auxiliary module acts autonomously and can be interpreted as an agent. Each agent is responsible for one joint and, therefore, the number of the agents of each expert is equal to the number of joints. Our results indicate that this architecture is robust against external disturbances, signal-dependent noise in sensory information, and changes in the environment. We also discuss the neurophysiological and behavioral basis of

  11. Accurate crop classification using hierarchical genetic fuzzy rule-based systems

    NASA Astrophysics Data System (ADS)

    Topaloglou, Charalampos A.; Mylonas, Stelios K.; Stavrakoudis, Dimitris G.; Mastorocostas, Paris A.; Theocharis, John B.

    2014-10-01

    This paper investigates the effectiveness of an advanced classification system for accurate crop classification using very high resolution (VHR) satellite imagery. Specifically, a recently proposed genetic fuzzy rule-based classification system (GFRBCS) is employed, namely, the Hierarchical Rule-based Linguistic Classifier (HiRLiC). HiRLiC's model comprises a small set of simple IF-THEN fuzzy rules, easily interpretable by humans. One of its most important attributes is that its learning algorithm requires minimum user interaction, since the most important learning parameters affecting the classification accuracy are determined by the learning algorithm automatically. HiRLiC is applied in a challenging crop classification task, using a SPOT5 satellite image over an intensively cultivated area in a lake-wetland ecosystem in northern Greece. A rich set of higher-order spectral and textural features is derived from the initial bands of the (pan-sharpened) image, resulting in an input space comprising 119 features. The experimental analysis proves that HiRLiC compares favorably to other interpretable classifiers of the literature, both in terms of structural complexity and classification accuracy. Its testing accuracy was very close to that obtained by complex state-of-the-art classification systems, such as the support vector machines (SVM) and random forest (RF) classifiers. Nevertheless, visual inspection of the derived classification maps shows that HiRLiC is characterized by higher generalization properties, providing more homogeneous classifications that the competitors. Moreover, the runtime requirements for producing the thematic map was orders of magnitude lower than the respective for the competitors.

  12. Computer graphics: Programmers's Hierarchical Interactive Graphics System (PHIGS). Language bindings (Part 3. Ada). Category: Software standard. Subcategory: Graphics. Final report

    SciTech Connect

    Benigni, D.R.

    1990-01-01

    The publication announces the adoption of the American National Standard Programmer's Hierarchical Interactive Graphics System, ANSI X3.144-1988, as a Federal Information Processing Standard (FIPS). The standard specifies the control and data interchange between an application program and its graphic support system. It provides a set of functions and programming language bindings, (or toolbox package) for the definition, display and modification of two-dimensional (2D) or three-dimensional (3D) graphical data. In addition, the standard supports highly interactive processing and geometric articulation, multi-level or hierarchical graphics data, and rapid modification of both the graphics data and the relationships between the graphical data. The purpose of the standard is to promote portability of graphics application programs between different installations.

  13. An efficient algorithm for finding optimal gain-ratio multiple-split tests on hierarchical attributes in decision tree learning

    SciTech Connect

    Almuallim, H.; Akiba, Yasuhiro; Kaneda, Shigeo

    1996-12-31

    Given a set of training examples S and a tree-structured attribute x, the goal in this work is to find a multiple-split test defined on x that maximizes Quinlan`s gain-ratio measure. The number of possible such multiple-split tests grows exponentially in the size of the hierarchy associated with the attribute. It is, therefore, impractical to enumerate and evaluate all these tests in order to choose the best one. We introduce an efficient algorithm for solving this problem that guarantees maximizing the gain-ratio over all possible tests. For a training set of m examples and an attribute hierarchy of height d, our algorithm runs in time proportional to dm, which makes it efficient enough for practical use.

  14. Multiple system atrophy: pathogenic mechanisms and biomarkers.

    PubMed

    Jellinger, Kurt A; Wenning, Gregor K

    2016-06-01

    Multiple system atrophy (MSA) is a unique proteinopathy that differs from other α-synucleinopathies since the pathological process resulting from accumulation of aberrant α-synuclein (αSyn) involves the oligodendroglia rather than neurons, although both pathologies affect multiple parts of the brain, spinal cord, autonomic and peripheral nervous system. Both the etiology and pathogenesis of MSA are unknown, although animal models have provided insight into the basic molecular changes of this disorder. Accumulation of aberrant αSyn in oligodendroglial cells and preceded by relocation of p25α protein from myelin to oligodendroglia results in the formation of insoluble glial cytoplasmic inclusions that cause cell dysfunction and demise. These changes are associated with proteasomal, mitochondrial and lipid transport dysfunction, oxidative stress, reduced trophic transport, neuroinflammation and other noxious factors. Their complex interaction induces dysfunction of the oligodendroglial-myelin-axon-neuron complex, resulting in the system-specific pattern of neurodegeneration characterizing MSA as a synucleinopathy with oligodendroglio-neuronopathy. Propagation of modified toxic αSyn species from neurons to oligodendroglia by "prion-like" transfer and its spreading associated with neuronal pathways result in a multi-system involvement. No reliable biomarkers are currently available for the clinical diagnosis and prognosis of MSA. Multidisciplinary research to elucidate the genetic and molecular background of the deleterious cycle of noxious processes, to develop reliable diagnostic biomarkers and to deliver targets for effective treatment of this hitherto incurable disorder is urgently needed.

  15. Toward Scalable Fabrication of Hierarchical Silica Capsules with Integrated Micro-, Meso-, and Macropores.

    PubMed

    Zhou, Weizheng; Tong, Gangsheng; Wang, Dali; Zhu, Bangshang; Ren, Yu; Butler, Michael; Pelan, Eddie; Yan, Deyue; Zhu, Xinyuan; Stoyanov, Simeon D

    2016-04-01

    Hierarchical porous structures are ubiquitous in biological organisms and inorganic systems. Although such structures have been replicated, designed, and fabricated, they are often inferior to naturally occurring analogues. Apart from the complexity and multiple functionalities developed by the biological systems, the controllable and scalable production of hierarchically porous structures and building blocks remains a technological challenge. Herein, a facile and scalable approach is developed to fabricate hierarchical hollow spheres with integrated micro-, meso-, and macropores ranging from 1 nm to 100 μm (spanning five orders of magnitude). (Macro)molecules, micro-rods (which play a key role for the creation of robust capsules), and emulsion droplets have been successfully employed as multiple length scale templates, allowing the creation of hierarchical porous macrospheres. Thanks to their specific mechanical strength, these hierarchical porous spheres could be incorporated and assembled as higher level building blocks in various novel materials. PMID:26863934

  16. Controlled fabrication of SrMoO{sub 4} hierarchical nanosheets in a surfactant-assisted nonaqueous system

    SciTech Connect

    Lei, Shuijin; Peng, Xiaomin; Li, Xiuping; Liang, Zhihong; Yang, Yi; Cheng, Baochang; Xiao, Yanhe; Zhou, Lang

    2011-04-15

    Research highlights: {yields} An imitated nonaqueous microemulsion system was developed. {yields} Various hierarchical architectures of SrMoO{sub 4} nanosheets were fabricated. {yields} The solvent, surfactant, reaction temperature and reaction time were important. {yields} The products emit a strong blue (474 nm) and weak green (573 nm) luminescence. -- Abstract: Various hierarchical architectures of SrMoO{sub 4} nanosheets (thickness of 8-9 nm) have been successfully prepared in nonaqueous system by a surfactant-assisted solvothermal method. X-ray powder diffraction, scanning electron microscopy and transmission electron microscopy were employed to study the crystal structure and morphologies of the products. Experiments showed that the solvent, surfactant, reaction temperature and reaction time were crucial for the oriented aggregation of the SrMoO{sub 4} nanosheets. Morphological control of these parameters resulted in platelet, column, interlaced multilayer and nest of nanosheets. A possible growth mechanism for these hierarchical architectures has also been proposed according to the morphological evolution with the reaction time. The optical properties of the products were also examined by means of photoluminescence and excitation spectroscopy. Photoluminescence studies revealed that these SrMoO{sub 4} nanocrystals exhibited a greatly strong blue emission under 325-nm excitation with different intensities but centered at the same position of 474 nm.

  17. The Hierarchical Ordering of Conceptual Systems in Biology: Problems of Student Teachers.

    ERIC Educational Resources Information Center

    Boschhuizen, Robert

    1988-01-01

    This article illustrates some problems faced by student teachers of biology when they try to realize the process of "didactic transformation" while planning their classes. To address these problems, a method of subject-matter analysis, utilizing hierarchical concept-maps, was introduced into the teacher training component at the Free University in…

  18. Multiple Bifurcations of a Cylindrical Dynamical System

    NASA Astrophysics Data System (ADS)

    Han, Ning; Cao, Qingjie

    2016-03-01

    This paper focuses on multiple bifurcations of a cylindrical dynamical system, which is evolved from a rotating pendulum with SD oscillator. The rotating pendulum system exhibits the coupling dynamics property of the bistable state and conventional pendulum with the ho- moclinic orbits of the first and second type. A double Andronov-Hopf bifurcation, two saddle-node bifurcations of periodic orbits and a pair of homoclinic bifurcations are detected by using analytical analysis and nu- merical calculation. It is found that the homoclinic orbits of the second type can bifurcate into a pair of rotational limit cycles, coexisting with the oscillating limit cycle. Additionally, the results obtained herein, are helpful to explore different types of limit cycles and the complex dynamic bifurcation of cylindrical dynamical system.

  19. A multispecialist teleconsultation system using multiple unicasting.

    PubMed

    Yoo, Sun K; Kim, Sun H; Jung, S M; Park, In-Cheol; Chun, Hye J; Seo, Kuk-Jin

    2007-10-01

    Multispecialist teleconsultation systems can be particularly useful in obtaining a second opinion from remote medical specialists. In this paper, a multispecialist teleconsultation (MST) system was designed by using multiple unicasting to enable operability over the existing Internet infrastructure and the support of reliable data transmission. The MST was tested over Asynchronous Digital Subscriber Line (ADSL), Very high speed Digital Subscriber Line (VDSL), Wireless Local Area Network (WLAN), and the hospital Local Area Network (LAN) to demonstrate the operability of the designed system over popularly deployed networks that together make up the current Internet. Also, subjective evaluation using induced delay and low quality video coding of sample brain surgery testing videos and two cases of clinical experimentations demonstrated the limiting factors of the MST in terms of quality and delay differences as well as the feasibility of the MST in a real clinical setting.

  20. [Susceptibility gene in multiple system atrophy (MSA)].

    PubMed

    Tsuji, Shoji

    2014-01-01

    To elucidate molecular bases of multiple system atrophy (MSA), we first focused on recently identified MSA multiplex families. Though linkage analyses followed by whole genome resequencing, we have identified a causative gene, COQ2, for MSA. We then conducted comprehensive nucleotide sequence analysis of COQ2 of sporadic MSA cases and controls, and found that functionally deleterious COQ2 variants confer a strong risk for developing MSA. COQ2 encodes an enzyme in the biosynthetic pathway of coenzyme Q10. Decreased synthesis of coenzyme Q10 is considered to be involved in the pathogenesis of MSA through decreased electron transport in mitochondria and increased vulnerability to oxidative stress. PMID:25672683

  1. Performance of random multiple access transmission system

    NASA Technical Reports Server (NTRS)

    Phinainitisart, N.; Wu, W. W.

    1990-01-01

    The performance of the Random Multiple Access (RMA) technique, applied to a direct terminal-to-terminal link with a large number of potential users, is determined. The average signal-to-noise ratio (SNR) is derived. Under Gaussian assumption, the approximation of the probability of error is given. The analysis shows that the system performance is affected by the sequence length, the number of simultaneous users, and the number of cochannel symbols, but is not sensitive to the thermal noise. The performance of using very small aperture antenna for both transmitting and receiving without a hub station is given.

  2. Systemic Sclerosis with Multiple Pulmonary Manifestations

    PubMed Central

    Suresh, Parinita; Reddy, Venkata Siva Prasad; Sharma, Tarun; Salim, Nabil Ahmed

    2016-01-01

    Systemic sclerosis (SSc) is a chronic autoimmune multisystem disorder characterized by endothelial dysfunction and fibroblast dysfunction, which results in progressive fibrosis of the skin and internal organs more frequently the lungs and gastro intestinal tract. Pulmonary involvement is common in the course of SSc, with Interstitial Lung Disease (ILD) and Pulmonary Arterial Hypertension (PAH) being the leading causes of death. Here we report, case of an elderly female patient presenting with Diffuse SSc with multiple uncommon pulmonary manifestations like ILD with Usual Interstitial Pneumonia (UIP) pattern (usually less common), PAH and right sided pleural effusion. PMID:27504339

  3. Multiple System Atrophy: Genetic or Epigenetic?

    PubMed Central

    Sturm, Edith

    2014-01-01

    Multiple system atrophy (MSA) is a rare, late-onset and fatal neurodegenerative disease including multisystem neurodegeneration and the formation of α-synuclein containing oligodendroglial cytoplasmic inclusions (GCIs), which present the hallmark of the disease. MSA is considered to be a sporadic disease; however certain genetic aspects have been studied during the last years in order to shed light on the largely unknown etiology and pathogenesis of the disease. Epidemiological studies focused on the possible impact of environmental factors on MSA disease development. This article gives an overview on the findings from genetic and epigenetic studies on MSA and discusses the role of genetic or epigenetic factors in disease pathogenesis. PMID:25548529

  4. QSO Metal Absorption Systems at High Redshift and the Signature of Hierarchical Galaxy Formation

    NASA Astrophysics Data System (ADS)

    Rauch, Michael; Haehnelt, Martin G.; Steinmetz, Matthias

    1997-05-01

    In a hierarchical cosmogony, galaxies build up by continuous merging of smaller structures. At z = 3, the matter content of a typical present-day galaxy is dispersed over several individual clumps embedded in sheetlike structures, often aligned along filaments. We have used hydrodynamical simulations to investigate the spatial distribution and absorption properties of metal-enriched gas in such regions of ongoing galaxy formation. The metal and hydrogen absorption features produced by the collapsing structures closely resemble observed QSO absorption systems over a wide range in H I column density. Strong C II and Si IV absorption occurs for lines of sight passing the densest regions close to the center of the protogalactic clumps, while C IV is a good tracer of the prominent filamentary structures and O VI becomes the strongest absorption feature for lines of sight passing through low-density regions far away from fully collapsed objects. The observed column density ratios of the different ionic species at z = 3 can be well reproduced if a mean metallicity [Z/H] = -2.5, relative abundances as found in metal-poor stars, a UV background with intensity J-22 = 3 at the Lyman limit, and either a power-law spectrum (J ~ ν-1.5) or the spectral shape proposed by Haardt & Madau are assumed. The observed scatter in [C/H] is about a magnitude larger than that in the simulations, which suggests an inhomogeneous metal distribution. Observed and simulated Doppler parameter distributions of H I and C IV absorption lines are in good agreement, which indicates that shock heating due to gravitational collapse is a second important heating agent in addition to photoionization heating. The large velocity spreads seen in some C IV systems may be due to the occasional alignments of the observer's line of sight with expanding large-scale filaments. Both high-ionization multicomponent heavy-element absorbers and damped Lyα systems can arise from groups of moderately sized protogalactic

  5. Dynamics of Kepler's Multiple Planet Systems

    NASA Astrophysics Data System (ADS)

    Lissauer, Jack J.; Kepler Science Team

    2012-10-01

    Among the 1800 Kepler targets that have candidate planets, 20% have two or more candidate planets. While most of these objects have not yet been confirmed as true planets, several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Virtually all candidate systems are stable, as tested by numerical integrations (assuming a physically motivated mass-radius relationship). The number of candidates in multiple candidate systems is more than 100 times as large as would be expected if planet candidates were distributed randomly among target stars, as would be the case for most types of false positives. Statistical studies performed on these candidate systems reveal a great deal about the architecture of planetary systems, including the typical spacing of orbits and flatness. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. The characteristics of some of the confirmed Kepler multi-planet systems will also be discussed.

  6. Hierarchical photocatalysts.

    PubMed

    Li, Xin; Yu, Jiaguo; Jaroniec, Mietek

    2016-05-01

    As a green and sustainable technology, semiconductor-based heterogeneous photocatalysis has received much attention in the last few decades because it has potential to solve both energy and environmental problems. To achieve efficient photocatalysts, various hierarchical semiconductors have been designed and fabricated at the micro/nanometer scale in recent years. This review presents a critical appraisal of fabrication methods, growth mechanisms and applications of advanced hierarchical photocatalysts. Especially, the different synthesis strategies such as two-step templating, in situ template-sacrificial dissolution, self-templating method, in situ template-free assembly, chemically induced self-transformation and post-synthesis treatment are highlighted. Finally, some important applications including photocatalytic degradation of pollutants, photocatalytic H2 production and photocatalytic CO2 reduction are reviewed. A thorough assessment of the progress made in photocatalysis may open new opportunities in designing highly effective hierarchical photocatalysts for advanced applications ranging from thermal catalysis, separation and purification processes to solar cells.

  7. HD 35502: a hierarchical triple system with a magnetic B5IVpe primary

    NASA Astrophysics Data System (ADS)

    Sikora, J.; Wade, G. A.; Bohlender, D. A.; Shultz, M.; Adelman, S. J.; Alecian, E.; Hanes, D.; Monin, D.; Neiner, C.; MiMeS Collaboration; BinaMIcS Collaboration

    2016-08-01

    We present our analysis of HD 35502 based on high- and medium-resolution spectropolarimetric observations. Our results indicate that the magnetic B5IVsnp star is the primary component of a spectroscopic triple system and that it has an effective temperature of 18.4 ± 0.6 kK, a mass of 5.7 ± 0.6 M⊙, and a polar radius of 3.0^{+1.1}_{-0.5} R_{odot }. The two secondary components are found to be essentially identical A-type stars for which we derive effective temperatures (8.9 ± 0.3 kK), masses (2.1 ± 0.2 M⊙), and radii (2.1 ± 0.4 R⊙). We infer a hierarchical orbital configuration for the system in which the secondary components form a tight binary with an orbital period of 5.668 66(6) d that orbits the primary component with a period of over 40 yr. Least-Squares Deconvolution profiles reveal Zeeman signatures in Stokes V indicative of a longitudinal magnetic field produced by the B star ranging from approximately -4 to 0 kG with a median uncertainty of 0.4 kG. These measurements, along with the line variability produced by strong emission in Hα, are used to derive a rotational period of 0.853 807(3) d. We find that the measured v sin i = 75 ± 5 km s-1 of the B star then implies an inclination angle of the star's rotation axis to the line of sight of 24^{+6}_{-10}{}^circ. Assuming the Oblique Rotator Model, we derive the magnetic field strength of the B star's dipolar component (14^{+9}_{-3} kG) and its obliquity (63± 13deg). Furthermore, we demonstrate that the calculated Alfvén radius (41^{+17}_{-6}R_ast) and Kepler radius (2.1^{+0.4}_{-0.7}R_ast) place HD 35502's central B star well within the regime of centrifugal magnetosphere-hosting stars.

  8. Force regulation in multiple-manipulator systems

    NASA Technical Reports Server (NTRS)

    Wen, John T.; Murphy, Steve H.

    1992-01-01

    A new intuitively appealing interpretation of the internal force in a multiple-arm system is presented. The static gravity-free case is considered where internal force has a well-founded physical meaning. The case is extended to the general dynamic case by removing the inertial force through balancing it with the minimum amount of contact force. The remaining component in the contact force is considered to be the sole contributor to the inertial force. Existing techniques for force control can be used to obtain various stabilizing force set point control laws. Particular attention is given to the motion control strategy for multiple arm systems. Three types of control laws, feedback linearization, arms-as-actuators, and passive control, are addressed. The first two techniques provide simplified control tuning but require much model information. The latter approach is considered to be very robust with respect to the model, but good transient performance is more challenging to obtain. It is suggested to combine one of the model-based approaches with the passive control approach.

  9. Multiple channel optical data acquisition system

    DOEpatents

    Fasching, G.E.; Goff, D.R.

    1985-02-22

    A multiple channel optical data acquisition system is provided in which a plurality of remote sensors monitoring specific process variable are interrogated by means of a single optical fiber connecting the remote station/sensors to a base station. The remote station/sensors derive all power from light transmitted through the fiber from the base station. Each station/sensor is individually accessed by means of a light modulated address code sent over the fiber. The remote station/sensors use a single light emitting diode to both send and receive light signals to communicate with the base station and provide power for the remote station. The system described can power at least 100 remote station/sensors over an optical fiber one mile in length.

  10. Multiple Cellulase System from Streptomyces antibioticus1

    PubMed Central

    Enger, M. D.; Sleeper, B. P.

    1965-01-01

    Enger, M. D. (North Dakota State University, Fargo), and B. P. Sleeper. Multiple cellulase system from Streptomyces antibioticus. J. Bacteriol. 89:23–27. 1965.—Starch-block zone electrophoresis was used to isolate five electrophoretically distinct, active cellulolytic components (I to V) from the crude extracellular cellulase system of Streptomyces antibioticus (strain C2A). Agar diffusion precipitin analyses demonstrated the immunological identity of components I, II, and III, and the nonidentity of IV and V with each other and with I to III. Kinetic studies of the purified enzymes showed a sharp decrease in the viscosity of the substrate, carboxymethylcellulose, with only a small increase in reducing sugars. These results indicated that all five enzymes are endocellulases. PMID:14255670

  11. Multiple beam antenna/switch system study

    NASA Technical Reports Server (NTRS)

    1989-01-01

    In the study of the Multiple Beam Antenna/Switch for the space to ground link (SGL) uplink and downlink services, several issues related to system engineering, antenna, transmit/receive, and switch systems were addressed and the results are provided. Bandwidth allocation at Ku band is inadequate to serve the data rate requirements for the forward and return services. Rain and depolarization effects at EHF, especially at Ka band, pose a significant threat to the link availabilities at heavy rain areas. Hardware induced effects such as the nonlinear characteristics of the power amplifier may necessitate the use of linearizers and limiters. It is also important to identify the components that are susceptible to the space radiation effects and shield or redesign them with rad-hard technologies for meeting the requirements of the space environment.

  12. A Descriptive Decision Process Model for Hierarchical Management of Interconnected Reservoir Systems

    NASA Astrophysics Data System (ADS)

    Adigüzel, R. Ä.°Lker; CoşKunoǧLu, Osman

    1984-07-01

    A significant limitation of prescriptive optimization models is that their formulation is disassociated from the behavioral and organizational attributes of the problem addressed. In an attempt to alleviate this limitation a decision process model is formulated directly within a framework of decision agents involved in integrated long- and short-term planning and management of multipurpose and multireservoir system operations. The resulting model is ierarchical, multilevel, multilayer, and decentralized. As such it is descriptive of a reservoir system managed and operated by geographically separated multiple agents with different authorities and responsibilities. Robustness and performance of the model is investigated by using the Shasta-Trinity system of California as an example. Results are encouraging for the descriptive as well as prescriptive relevance of the model.

  13. Definitions of state variables and state space for brain-computer interface : Part 1. Multiple hierarchical levels of brain function.

    PubMed

    Freeman, Walter J

    2007-03-01

    Neocortical state variables are defined and evaluated at three levels: microscopic using multiple spike activity (MSA), mesoscopic using local field potentials (LFP) and electrocorticograms (ECoG), and macroscopic using electroencephalograms (EEG) and brain imaging. Transactions between levels occur in all areas of cortex, upwardly by integration (abstraction, generalization) and downwardly by differentiation (speciation). The levels are joined by circular causality: microscopic activity upwardly creates mesoscopic order parameters, which downwardly constrain the microscopic activity that creates them. Integration dominates in sensory cortices. Microscopic activity evoked by receptor input in sensation induces emergence of mesoscopic activity in perception, followed by integration of perceptual activity into macroscopic activity in concept formation. The reverse process dominates in motor cortices, where the macroscopic activity embodying the concepts supports predictions of future states as goals. These macroscopic states are conceived to order mesoscopic activity in patterns that constitute plans for actions to achieve the goals. These planning patterns are conceived to provide frames in which the microscopic activity evolves in trajectories that adapted to the immediate environmental conditions detected by new stimuli. This circular sequence forms the action-perception cycle. Its upward limb is understood through correlation of sensory cortical activity with behavior. Now brain-machine interfaces (BMI) offer a means to understand the downward sequence through correlation of behavior with motor cortical activity, beginning with macroscopic goal states and concluding with recording of microscopic MSA trajectories that operate neuroprostheses. Part 1 develops a hypothesis that describes qualitatively the neurodynamics that supports the action-perception cycle and derivative reflex arc. Part 2 describes episodic, "cinematographic" spatial pattern formation and

  14. A hierarchical-multiobjective framework for risk management

    NASA Technical Reports Server (NTRS)

    Haimes, Yacov Y.; Li, Duan

    1991-01-01

    A broad hierarchical-multiobjective framework is established and utilized to methodologically address the management of risk. United into the framework are the hierarchical character of decision-making, the multiple decision-makers at separate levels within the hierarchy, the multiobjective character of large-scale systems, the quantitative/empirical aspects, and the qualitative/normative/judgmental aspects. The methodological components essentially consist of hierarchical-multiobjective coordination, risk of extreme events, and impact analysis. Examples of applications of the framework are presented. It is concluded that complex and interrelated forces require an analysis of trade-offs between engineering analysis and societal preferences, as in the hierarchical-multiobjective framework, to successfully address inherent risk.

  15. Image Information Mining Utilizing Hierarchical Segmentation

    NASA Technical Reports Server (NTRS)

    Tilton, James C.; Marchisio, Giovanni; Koperski, Krzysztof; Datcu, Mihai

    2002-01-01

    The Hierarchical Segmentation (HSEG) algorithm is an approach for producing high quality, hierarchically related image segmentations. The VisiMine image information mining system utilizes clustering and segmentation algorithms for reducing visual information in multispectral images to a manageable size. The project discussed herein seeks to enhance the VisiMine system through incorporating hierarchical segmentations from HSEG into the VisiMine system.

  16. Robot motion tracking system with multiple views

    NASA Astrophysics Data System (ADS)

    Yamano, Hiroshi; Saito, Hideo

    2001-10-01

    In such a space where human workers and industrial robots work together, it has become necessary to monitor a robot motion for the safety. For such robot surveillance, we propose a robot tracking system from multiple view images. In this system, we treat tracking robot movement problem as an estimation problem of each pose parameter through all frames. This tracking algorithm consists of four stages, image generating stage, estimation stage, parameter searching stage, and prediction stage. At the first stage, robot area of real image is extracted by background subtraction. Here, Yuv color system is used because of reducing the change of lighting condition. By calibrating extrinsic and intrinsic parameters of all cameras with Tsai's method, we can project 3D model of the robot onto each camera. In the next stage, correlation of the input image and projected model image is calculated, which is defined by the area of robots in real and 3D images. At third stage, the pose parameters of the robot are estimated by maximizing the correlation. For computational efficiency, a high dimensional pose parameter space is divided into many low dimensional sub-spaces in accordance with the predicted pose parameters in the previous flame. We apply the proposed system for pose estimation of 5-axis robot manipulator. The estimated pose parameters are successfully matched with the actual pose of the robots.

  17. MPACT Fast Neutron Multiplicity System Design Concepts

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; J. L. Dolan; M. T. Kinlaw; A. C. Kaplan; M. Flaska; A. Enqvist; J. T. Johnsom; S. M. Watson

    2012-10-01

    This report documents work performed by Idaho National Laboratory and the University of Michigan in fiscal year (FY) 2012 to examine design parameters related to the use of fast-neutron multiplicity counting for assaying plutonium for materials protection, accountancy, and control purposes. This project seeks to develop a new type of neutron-measurement-based plutonium assay instrument suited for assaying advanced fuel cycle materials. Some current-concept advanced fuels contain high concentrations of plutonium; some of these concept fuels also contain other fissionable actinides besides plutonium. Because of these attributes the neutron emission rates of these new fuels may be much higher, and more difficult to interpret, than measurements made of plutonium-only materials. Fast neutron multiplicity analysis is one approach for assaying these advanced nuclear fuels. Studies have been performed to assess the conceptual performance capabilities of a fast-neutron multiplicity counter for assaying plutonium. Comparisons have been made to evaluate the potential improvements and benefits of fast-neutron multiplicity analyses versus traditional thermal-neutron counting systems. Fast-neutron instrumentation, using for example an array of liquid scintillators such as EJ-309, have the potential to either a) significantly reduce assay measurement times versus traditional approaches, for comparable measurement precision values, b) significantly improve assay precision values, for measurement durations comparable to current-generation technology, or c) moderating improve both measurement precision and measurement durations versus current-generation technology. Using the MCNPX-PoliMi Monte Carlo simulation code, studies have been performed to assess the doubles-detection efficiency for a variety of counter layouts of cylindrical liquid scintillator detector cells over one, two, and three rows. Ignoring other considerations, the best detector design is the one with the most

  18. Hierarchical modelling of mobile, seeing robots

    NASA Technical Reports Server (NTRS)

    Luh, Cheng-Jye; Zeigler, Bernard P.

    1990-01-01

    This paper describes the implementation of a hierarchical robot simulation which supports the design of robots with vision and mobility. A seeing robot applies a classification expert system for visual identification of laboratory objects. The visual data acquisition algorithm used by the robot vision system has been developed to exploit multiple viewing distances and perspectives. Several different simulations have been run testing the visual logic in a laboratory environment. Much work remains to integrate the vision system with the rest of the robot system.

  19. Resilient model approximation for Markov jump time-delay systems via reduced model with hierarchical Markov chains

    NASA Astrophysics Data System (ADS)

    Zhu, Yanzheng; Zhang, Lixian; Sreeram, Victor; Shammakh, Wafa; Ahmad, Bashir

    2016-10-01

    In this paper, the resilient model approximation problem for a class of discrete-time Markov jump time-delay systems with input sector-bounded nonlinearities is investigated. A linearised reduced-order model is determined with mode changes subject to domination by a hierarchical Markov chain containing two different nonhomogeneous Markov chains. Hence, the reduced-order model obtained not only reflects the dependence of the original systems but also model external influence that is related to the mode changes of the original system. Sufficient conditions formulated in terms of bilinear matrix inequalities for the existence of such models are established, such that the resulting error system is stochastically stable and has a guaranteed l2-l∞ error performance. A linear matrix inequalities optimisation coupled with line search is exploited to solve for the corresponding reduced-order systems. The potential and effectiveness of the developed theoretical results are demonstrated via a numerical example.

  20. Probabilistic deployment for multiple sensor systems

    NASA Astrophysics Data System (ADS)

    Qian, Ming; Ferrari, Silvia

    2005-05-01

    The performance of many multi-sensor systems can be significantly improved by using a priori environmental information and sensor data to plan the movements of sensor platforms that are later deployed with the purpose of improving the quality of the final detection and classification results. However, existing path planning algorithms and ad-hoc data processing (e.g., fusion) techniques do not allow for the systematic treatment of multiple and heterogeneous sensors and their platforms. This paper presents a method that combines Bayesian network inference with probabilistic roadmap (PRM) planners to utilize the information obtained by different sensors and their level of uncertainty. The uncertainty of prior sensed information is represented by entropy values obtained from the Bayesian network (BN) models of the respective sensor measurement processes. The PRM algorithm is modified to utilize the entropy distribution in optimizing the path of posterior sensor platforms that have the following objectives: (1) improve the quality of the sensed information, i.e., through fusion, (2) minimize the distance traveled by the platforms, and (3) avoid obstacles. This so-called Probabilistic Deployment (PD) method is applied to a demining system comprised of ground-penetrating radars (GPR), electromagnetic (EMI), and infrared sensors (IR) installed on ground platforms, to detect and classify buried mines. Numerical simulations show that PD is more efficient than path planning techniques that do not utilize a priori information, such as complete coverage, random coverage method, or PRM methods that do not utilize Bayesian inference.

  1. Parallel hierarchical radiosity rendering

    SciTech Connect

    Carter, M.

    1993-07-01

    In this dissertation, the step-by-step development of a scalable parallel hierarchical radiosity renderer is documented. First, a new look is taken at the traditional radiosity equation, and a new form is presented in which the matrix of linear system coefficients is transformed into a symmetric matrix, thereby simplifying the problem and enabling a new solution technique to be applied. Next, the state-of-the-art hierarchical radiosity methods are examined for their suitability to parallel implementation, and scalability. Significant enhancements are also discovered which both improve their theoretical foundations and improve the images they generate. The resultant hierarchical radiosity algorithm is then examined for sources of parallelism, and for an architectural mapping. Several architectural mappings are discussed. A few key algorithmic changes are suggested during the process of making the algorithm parallel. Next, the performance, efficiency, and scalability of the algorithm are analyzed. The dissertation closes with a discussion of several ideas which have the potential to further enhance the hierarchical radiosity method, or provide an entirely new forum for the application of hierarchical methods.

  2. The Challenge of Multiple Perspectives: Multiple Solution Tasks for Students Incorporating Diverse Tools and Representation Systems

    ERIC Educational Resources Information Center

    Kordaki, Maria

    2015-01-01

    This study focuses on the role of multiple solution tasks (MST) incorporating multiple learning tools and representation systems (MTRS) in encouraging each student to develop multiple perspectives on the learning concepts under study and creativity of thought. Specifically, two types of MST were used, namely tasks that allowed and demanded…

  3. Spatiotemporal antibiotic resistance pattern monitoring using geographical information system based hierarchical cluster analysis.

    PubMed

    Hewapathirana, Roshan; Wijayarathna, Gamini

    2010-01-01

    Bacterial antimicrobial resistance in both the medical and agricultural fields has become a serious problem worldwide. Antibiotic resistant strains of bacteria are an increasing threat to human health, with resistance mechanisms having been described to all known antimicrobials currently available for clinical use. Monitoring the geotemporal variations of antibiotic resistance pattern is crucial factor in planning a successful therapeutic guidelines preventing further emergence of antibiotic resistance. This study is based on the retrospective spatiotemporal analysis of laboratory results of Antibiotic Sensitivity Tests, time stamped with the date and time of the microbiological specimen dispatched to the laboratory. Geographic location of the isolated bacterial colony is specified with the latitude and the longitude of the patient's location. Agglomerative Hierarchical Clustering was performed on antimicrobial resistance findings based on the geographic locations generating series of Heatmaps to visualize the extent of the resistance pattern. Sequential Hierarchical cluster analysis was proven to be effective in visualization of antibiotic resistance using Heatmaps demonstrating the temporal variations of the antibiotic resistance patterns.

  4. Hierarchical control of ride height system for electronically controlled air suspension based on variable structure and fuzzy control theory

    NASA Astrophysics Data System (ADS)

    Xu, Xing; Zhou, Kongkang; Zou, Nannan; Jiang, Hong; Cui, Xiaoli

    2015-09-01

    The current research of air suspension mainly focuses on the characteristics and design of the air spring. In fact, electronically controlled air suspension (ECAS) has excellent performance in flexible height adjustment during different driving conditions. However, the nonlinearity of the ride height adjusting system and the uneven distribution of payload affect the control accuracy of ride height and the body attitude. Firstly, the three-point measurement system of three height sensors is used to establish the mathematical model of the ride height adjusting system. The decentralized control of ride height and the centralized control of body attitude are presented to design the ride height control system for ECAS. The exact feedback linearization method is adopted for the nonlinear mathematical model of the ride height system. Secondly, according to the hierarchical control theory, the variable structure control (VSC) technique is used to design a controller that is able to adjust the ride height for the quarter-vehicle anywhere, and each quarter-vehicle height control system is independent. Meanwhile, the three-point height signals obtained by three height sensors are tracked to calculate the body pitch and roll attitude over time, and then by calculating the deviation of pitch and roll and its rates, the height control correction is reassigned based on the fuzzy algorithm. Finally, to verify the effectiveness and performance of the proposed combined control strategy, a validating test of ride height control system with and without road disturbance is carried out. Testing results show that the height adjusting time of both lifting and lowering is over 5 s, and the pitch angle and the roll angle of body attitude are less than 0.15°. This research proposes a hierarchical control method that can guarantee the attitude stability, as well as satisfy the ride height tracking system.

  5. Intelligent multiagent coordination based on reinforcement hierarchical neuro-fuzzy models.

    PubMed

    Mendoza, Leonardo Forero; Vellasco, Marley; Figueiredo, Karla

    2014-12-01

    This paper presents the research and development of two hybrid neuro-fuzzy models for the hierarchical coordination of multiple intelligent agents. The main objective of the models is to have multiple agents interact intelligently with each other in complex systems. We developed two new models of coordination for intelligent multiagent systems, which integrates the Reinforcement Learning Hierarchical Neuro-Fuzzy model with two proposed coordination mechanisms: the MultiAgent Reinforcement Learning Hierarchical Neuro-Fuzzy with a market-driven coordination mechanism (MA-RL-HNFP-MD) and the MultiAgent Reinforcement Learning Hierarchical Neuro-Fuzzy with graph coordination (MA-RL-HNFP-CG). In order to evaluate the proposed models and verify the contribution of the proposed coordination mechanisms, two multiagent benchmark applications were developed: the pursuit game and the robot soccer simulation. The results obtained demonstrated that the proposed coordination mechanisms greatly improve the performance of the multiagent system when compared with other strategies.

  6. Microparticles with hierarchical porosity

    SciTech Connect

    Petsev, Dimiter N; Atanassov, Plamen; Pylypenko, Svitlana; Carroll, Nick; Olson, Tim

    2012-12-18

    The present disclosure provides oxide microparticles with engineered hierarchical porosity and methods of manufacturing the same. Also described are structures that are formed by templating, impregnating, and/or precipitating the oxide microparticles and method for forming the same. Suitable applications include catalysts, electrocatalysts, electrocatalysts support materials, capacitors, drug delivery systems, sensors and chromatography.

  7. [Multiple system atrophy - synuclein and neuronal degeneration].

    PubMed

    Yoshida, Mari

    2011-11-01

    Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that encompasses olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy-Drager syndrome (SDS). The histopathological hallmarks are α-synuclein (AS) positive glial cytoplasmic inclusions (GCIs) in oligodendroglias. AS aggregation is also found in glial nuclear inclusions (GNIs), neuronal cytoplasmic inclusions (NCIs), neuronal nuclear inclusions (NNIs) and dystrophic neurties. Reviewing the pathological features of 102 MSA cases, OPCA-type was relatively more frequent and SND-type was less frequent in Japanese MSA cases, which suggested different phenotypic pattern of MSA might exist between races, compared to the relatively high frequency of SND-type in western countries. In early stage of MSA, NNIs, NCIs and diffuse homogenous stain of AS in neuronal nuclei and cytoplasm were observed in various vulnerable lesions including the pontine nuclei, putamen, substantia nigra, locus ceruleus, inferior olivary nucleus, intermediolateral column of thoracic cord, lower motor neurons and cortical pyramidal neurons, in additions to GCIs. These findings indicated that the primary nonfibrillar and fibrillar AS aggregation also occurred in neurons. Therefore both the direct involvement of neurons themselves and the oligodendroglia-myelin-axon mechanism may synergistically accelerate the degenerative process of MSA. PMID:22277386

  8. Novel Therapeutic Approaches in Multiple System Atrophy

    PubMed Central

    Palma, Jose-Alberto; Kaufmann, Horacio

    2014-01-01

    Multiple system atrophy (MSA) is a sporadic, adult onset, relentlessly, progressive neurodegenerative disease characterized by autonomic abnormalities associated with parkinsonism, cerebellar dysfunction, pyramidal signs, or combinations thereof. Treatments that can halt or reverse the progression of MSA have not yet been identified. MSA is neuropathologically defined by the presence of α-synuclein–containing inclusions, particularly in the cytoplasm of oligodendrocytes (glial cytoplasmic inclusions, GCIs), which are associated with neurodegeneration. The mechanisms by which oligodendrocytic α-synuclein inclusions cause neuronal death in MSA are not completely understood. The MSA neurodegenerative process likely comprise cell-to-cell transmission of α-synuclein in a prion-like manner, α-synuclein aggregation, increased oxidative stress, abnormal expression of tubulin proteins, decreased expression of neurotrophic factors, excitotoxicity and microglial activation, and neuroinflammation. In an attempt to block each of these pathogenic mechanisms, several pharmacologic approaches have been tried and shown to exert neuroprotective effects in transgenic mouse or cellular models of MSA. These include sertraline, paroxetine, and lithium, which hamper arrival of α-synuclein to oligodendroglia; rifampicin, lithium, and non-steroidal anti-inflamatory drugs, which inhibit α-synuclein aggregation in oligodendrocytes; riluzole, rasagiline, fluoxetine and mesenchimal stem cells, which exert neuroprotective actions; and minocycline and intravenous immunoglobulins, which reduce neuroinflammation and microglial activation. These and other potential therapeutic strategies for MSA are summarized in this review. PMID:24928797

  9. Towards translational therapies for multiple system atrophy

    PubMed Central

    Kuzdas-Wood, Daniela; Stefanova, Nadia; Jellinger, Kurt A.; Seppi, Klaus; Schlossmacher, Michael G.; Poewe, Werner; Wenning, Gregor K.

    2014-01-01

    Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disorder of uncertain etiopathogenesis manifesting with autonomic failure, parkinsonism, and ataxia in any combination. The underlying neuropathology affects central autonomic, striatonigral and olivopontocerebellar pathways and it is associated with distinctive glial cytoplasmic inclusions (GCIs, Papp-Lantos bodies) that contain aggregates of α-synuclein. Current treatment options are very limited and mainly focused on symptomatic relief, whereas disease modifying options are lacking. Despite extensive testing, no neuroprotective drug treatment has been identified up to now; however, a neurorestorative approach utilizing autologous mesenchymal stem cells has shown remarkable beneficial effects in the cerebellar variant of MSA. Here, we review the progress made over the last decade in defining pathogenic targets in MSA and summarize insights gained from candidate disease-modifying interventions that have utilized a variety of well-established preclinical MSA models. We also discuss the current limitations that our field faces and suggest solutions for possible approaches in cause-directed therapies of MSA. PMID:24598411

  10. ξTauri: a unique laboratory to study the dynamic interaction in a compact hierarchical quadruple system

    NASA Astrophysics Data System (ADS)

    Nemravová, J. A.; Harmanec, P.; Brož, M.; Vokrouhlický, D.; Mourard, D.; Hummel, C. A.; Cameron, C.; Matthews, J. M.; Bolton, C. T.; Božić, H.; Chini, R.; Dembsky, T.; Engle, S.; Farrington, C.; Grunhut, J. H.; Guenther, D. B.; Guinan, E. F.; Korčáková, D.; Koubský, P.; Kříček, R.; Kuschnig, R.; Mayer, P.; McCook, G. P.; Moffat, A. F. J.; Nardetto, N.; Prša, A.; Ribeiro, J.; Rowe, J.; Rucinski, S.; Škoda, P.; Šlechta, M.; Tallon-Bosc, I.; Votruba, V.; Weiss, W. W.; Wolf, M.; Zasche, P.; Zavala, R. T.

    2016-10-01

    Context. Compact hierarchical systems are important because the effects caused by the dynamical interaction among its members occur ona human timescale. These interactions play a role in the formation of close binaries through Kozai cycles with tides. One such system is ξ Tauri: it has three hierarchical orbits: 7.14 d (eclipsing components Aa, Ab), 145 d (components Aa+Ab, B), and 51 yr (components Aa+Ab+B, C). Aims: We aim to obtain physical properties of the system and to study the dynamical interaction between its components. Methods: Our analysis is based on a large series of spectroscopic photometric (including space-borne) observations and long-baseline optical and infrared spectro-interferometric observations. We used two approaches to infer the system properties: a set of observation-specific models, where all components have elliptical trajectories, and an N-body model, which computes the trajectory of each component by integrating Newton's equations of motion. Results: The triple subsystem exhibits clear signs of dynamical interaction. The most pronounced are the advance of the apsidal line and eclipse-timing variations. We determined the geometry of all three orbits using both observation-specific and N-body models. The latter correctly accounted for observed effects of the dynamical interaction, predicted cyclic variations of orbital inclinations, and determined the sense of motion of all orbits. Using perturbation theory, we demonstrate that prominent secular and periodic dynamical effects are explainable with a quadrupole interaction. We constrained the basic properties of all components, especially of members of the inner triple subsystem and detected rapid low-amplitude light variations that we attribute to co-rotating surface structures of component B. We also estimated the radius of component B. Properties of component C remain uncertain because of its low relative luminosity. We provide an independent estimate of the distance to the system

  11. A Decentralized Approach to the Formulation of Hypotheses: A Hierarchical Structural Model for a Prion Self-Assembled System

    NASA Astrophysics Data System (ADS)

    Wang, Mingyang; Zhang, Feifei; Song, Chao; Shi, Pengfei; Zhu, Jin

    2016-07-01

    Innovation in hypotheses is a key transformative driver for scientific development. The conventional centralized hypothesis formulation approach, where a dominant hypothesis is typically derived from a primary phenomenon, can, inevitably, impose restriction on the range of conceivable experiments and legitimate hypotheses, and ultimately impede understanding of the system of interest. We report herein the proposal of a decentralized approach for the formulation of hypotheses, through initial preconception-free phenomenon accumulation and subsequent reticular logical reasoning processes. The two-step approach can provide an unbiased, panoramic view of the system and as such should enable the generation of a set of more coherent and therefore plausible hypotheses. As a proof-of-concept demonstration of the utility of this open-ended approach, a hierarchical model has been developed for a prion self-assembled system, allowing insight into hitherto elusive static and dynamic features associated with this intriguing structure.

  12. Minimax approach problem with incomplete information for the two-level hierarchical discrete-time dynamical system

    SciTech Connect

    Shorikov, A. F.

    2014-11-18

    We consider a discrete-time dynamical system consisting of three controllable objects. The motions of all objects are given by the corresponding vector linear or convex discrete-time recurrent vector relations, and control system for its has two levels: basic (first or I level) that is dominating and subordinate level (second or II level) and both have different criterions of functioning and united a priori by determined informational and control connections defined in advance. For the dynamical system in question, we propose a mathematical formalization in the form of solving a multistep problem of two-level hierarchical minimax program control over the terminal approach process with incomplete information and give a general scheme for its solution.

  13. A Decentralized Approach to the Formulation of Hypotheses: A Hierarchical Structural Model for a Prion Self-Assembled System

    PubMed Central

    Wang, Mingyang; Zhang, Feifei; Song, Chao; Shi, Pengfei; Zhu, Jin

    2016-01-01

    Innovation in hypotheses is a key transformative driver for scientific development. The conventional centralized hypothesis formulation approach, where a dominant hypothesis is typically derived from a primary phenomenon, can, inevitably, impose restriction on the range of conceivable experiments and legitimate hypotheses, and ultimately impede understanding of the system of interest. We report herein the proposal of a decentralized approach for the formulation of hypotheses, through initial preconception-free phenomenon accumulation and subsequent reticular logical reasoning processes. The two-step approach can provide an unbiased, panoramic view of the system and as such should enable the generation of a set of more coherent and therefore plausible hypotheses. As a proof-of-concept demonstration of the utility of this open-ended approach, a hierarchical model has been developed for a prion self-assembled system, allowing insight into hitherto elusive static and dynamic features associated with this intriguing structure. PMID:27464832

  14. Chemical Enrichment at High Redshifts: Understanding the Nature of Damped Lyα Systems in Hierarchical Models

    NASA Astrophysics Data System (ADS)

    Tissera, Patricia B.; Lambas, Diego G.; Mosconi, Mirta B.; Cora, Sofia

    2001-08-01

    We use cosmological hydrodynamical simulations including star formation and metal enrichment to study the evolution of the chemical properties of galaxy-like objects at high redshift in the range 0.25hierarchical clustering scenario. We find that as the galactic objects are assembled, their gaseous components exhibit neutral hydrogen column densities with abundances and scatter comparable to those observed in damped Lyα systems (DLAs). The unweighted mean of abundance ratios and least-square linear regressions through the simulated DLAs yield intrinsic metallicity evolution for [Zn/H] and [Fe/H] consistent with results obtained from similar analyses of available observations. Our model statistically reproduces the mild evolution detected in the metallicity of the neutral hydrogen content of the universe, given by mass-weighted means, if observational constraints are considered (as suggested in 1998 by Boissée and co-workers). For the α-elements in the simulated DLAs, we find neither enhancement nor dependence on metallicity. Our results support the hypotheses that DLAs trace a variety of galactic objects with different formation histories and that both Type I and Type II supernovae are contributing to the chemical enrichment of the gas component, at least since z~2. This study indicates that DLAs could be understood as the building blocks that merged to form current normal galaxies within a hierarchical clustering scenario.

  15. Multiple-channel Streaming Delivery for Omnidirectional Vision System

    NASA Astrophysics Data System (ADS)

    Iwai, Yoshio; Nagahara, Hajime; Yachida, Masahiko

    An omnidirectional vision is an imaging system that can capture a surrounding image in whole direction by using a hyperbolic mirror and a conventional CCD camera. This paper proposes a streaming server that can efficiently transfer movies captured by an omnidirectional vision system through the Internet. The proposed system uses multiple channels to deliver multiple movies synchronously. Through this method, the system enables clients to view the different direction of omnidirectional movies and also support the function to change the view are during playback period. Our evaluation experiments show that our proposed streaming server can effectively deliver multiple movies via multiple channels.

  16. Hierarchical multisensor analysis for robotic exploration

    NASA Technical Reports Server (NTRS)

    Eberlein, Susan; Yates, Gigi; Majani, Eric

    1991-01-01

    Robotic vehicles for lunar and Mars exploration will carry an array of complex instruments requiring real-time data interpretation and fusion. The system described here uses hierarchical multiresolution analysis of visible and multispectral images to extract information on mineral composition, texture and object shape. This information is used to characterize the site geology and choose interesting samples for acquisition. Neural networks are employed for many data analysis steps. A decision tree progressively integrates information from multiple instruments and performs goal-driven decision making. The system is designed to incorporate more instruments and data types as they become available.

  17. Deterministic hierarchical networks

    NASA Astrophysics Data System (ADS)

    Barrière, L.; Comellas, F.; Dalfó, C.; Fiol, M. A.

    2016-06-01

    It has been shown that many networks associated with complex systems are small-world (they have both a large local clustering coefficient and a small diameter) and also scale-free (the degrees are distributed according to a power law). Moreover, these networks are very often hierarchical, as they describe the modularity of the systems that are modeled. Most of the studies for complex networks are based on stochastic methods. However, a deterministic method, with an exact determination of the main relevant parameters of the networks, has proven useful. Indeed, this approach complements and enhances the probabilistic and simulation techniques and, therefore, it provides a better understanding of the modeled systems. In this paper we find the radius, diameter, clustering coefficient and degree distribution of a generic family of deterministic hierarchical small-world scale-free networks that has been considered for modeling real-life complex systems.

  18. Defining and enabling resiliency of electric distribution systems with multiple microgrids

    DOE PAGESBeta

    Chanda, Sayonsom; Srivastava, Anurag K.

    2016-05-02

    This paper presents a method for quantifying and enabling the resiliency of a power distribution system (PDS) using analytical hierarchical process and percolation theory. Using this metric, quantitative analysis can be done to analyze the impact of possible control decisions to pro-actively enable the resilient operation of distribution system with multiple microgrids and other resources. Developed resiliency metric can also be used in short term distribution system planning. The benefits of being able to quantify resiliency can help distribution system planning engineers and operators to justify control actions, compare different reconfiguration algorithms, develop proactive control actions to avert power systemmore » outage due to impending catastrophic weather situations or other adverse events. Validation of the proposed method is done using modified CERTS microgrids and a modified industrial distribution system. Furthermore, simulation results show topological and composite metric considering power system characteristics to quantify the resiliency of a distribution system with the proposed methodology, and improvements in resiliency using two-stage reconfiguration algorithm and multiple microgrids.« less

  19. The Dynamical Evolution of the Multiple Stellar System α Gem

    NASA Astrophysics Data System (ADS)

    Andrade, M.; Docobo, J. A.

    2015-07-01

    The sextuple system Castor (α Gem) comprises of a visual binary (Castor A and B) with an orbital period of approximately 460 years. Each of these components is a single-lined spectroscopic binary with an orbital period of only a few days. In addition, a distant double-lined spectroscopic eclipsing binary (Castor C, or YY Gem), with an orbital period of less than 1 day, is considered to be in orbit around them with a period of roughly 14 000 years or more. In this contribution, we study the long-term dynamics of this hierarchical system. Many orbital elements still remain unknown, mainly those regarding the AB-C system. Apart from the direct integration of the equations of motion for the quadruple (Aa,Ab)-(Ba,Bb) system, we also perform a qualitative analysis of the global system by means of numerical techniques in order to find the most distinctive features of its dynamics.

  20. Multiple operating system rotation environment moving target defense

    DOEpatents

    Evans, Nathaniel; Thompson, Michael

    2016-03-22

    Systems and methods for providing a multiple operating system rotation environment ("MORE") moving target defense ("MTD") computing system are described. The MORE-MTD system provides enhanced computer system security through a rotation of multiple operating systems. The MORE-MTD system increases attacker uncertainty, increases the cost of attacking the system, reduces the likelihood of an attacker locating a vulnerability, and reduces the exposure time of any located vulnerability. The MORE-MTD environment is effectuated by rotation of the operating systems at a given interval. The rotating operating systems create a consistently changing attack surface for remote attackers.

  1. Hierarchical structure in a self-created communication system: Building nominal constituents in homesign

    PubMed Central

    Hunsicker, Dea; Goldin-Meadow, Susan

    2013-01-01

    Deaf children whose hearing losses are so severe that they cannot acquire spoken language and whose hearing parents have not exposed them to sign language nevertheless use gestures, called homesigns, to communicate. Homesigners have been shown to refer to entities by pointing at that entity (a demonstrative, that). They also use iconic gestures and category points that refer, not to a particular entity, but to its class (a noun, bird). We used longitudinal data from a homesigner called David to test the hypothesis that these different types of gestures are combined to form larger, multi-gesture nominal constituents (that bird). We verified this hypothesis by showing that David's multi-gesture combinations served the same semantic and syntactic functions as demonstrative gestures or noun gestures used on their own. In other words, the larger unit substituted for the smaller units and, in this way, functioned as a nominal constituent. Children are thus able to refer to entities using multi-gesture units that contain both nouns and demonstratives, even when they do not have a conventional language to provide a model for this type of hierarchical constituent structure.* PMID:23626381

  2. Hierarchical patch dynamics and animal movement pattern.

    PubMed

    Fauchald, Per; Tveraa, Torkild

    2006-09-01

    In hierarchical patch systems, small-scale patches of high density are nested within large-scale patches of low density. The organization of multiple-scale hierarchical systems makes non-random strategies for dispersal and movement particularly important. Here, we apply a new method based on first-passage time on the pathway of a foraging seabird, the Antarctic petrel (Thalassoica antarctica), to quantify its foraging pattern and the spatial dynamics of its foraging areas. Our results suggest that Antarctic petrels used a nested search strategy to track a highly dynamic hierarchical patch system where small-scale patches were congregated within patches at larger scales. The birds searched for large-scale patches by traveling fast and over long distances. Once within a large-scale patch, the birds concentrated their search to find smaller scale patches. By comparing the pathway of different birds we were able to quantify the spatial scale and turnover of their foraging areas. On the largest scale we found foraging areas with a characteristic scale of about 400 km. Nested within these areas we found foraging areas with a characteristic scale of about 100 km. The large-scale areas disappeared or moved within a time frame of weeks while the nested small-scale areas disappeared or moved within days. Antarctic krill (Euphausia superba) is the dominant food item of Antarctic petrels and we suggest that our findings reflect the spatial dynamics of krill in the area. PMID:16794832

  3. Multiple channel secure communication using chaotic system encoding

    SciTech Connect

    Miller, S.L.

    1996-12-31

    fA new method to encrypt signals using chaotic systems has been developed that offers benefits over conventional chaotic encryption methods. The method simultaneously encodes multiple plaintext streams using a chaotic system; a key is required to extract the plaintext from the chaotic cipertext. A working prototype demonstrates feasibility of the method by simultaneously encoding and decoding multiple audio signals using electrical circuits.

  4. On Decision-Making Among Multiple Rule-Bases in Fuzzy Control Systems

    NASA Technical Reports Server (NTRS)

    Tunstel, Edward; Jamshidi, Mo

    1997-01-01

    Intelligent control of complex multi-variable systems can be a challenge for single fuzzy rule-based controllers. This class of problems cam often be managed with less difficulty by distributing intelligent decision-making amongst a collection of rule-bases. Such an approach requires that a mechanism be chosen to ensure goal-oriented interaction between the multiple rule-bases. In this paper, a hierarchical rule-based approach is described. Decision-making mechanisms based on generalized concepts from single-rule-based fuzzy control are described. Finally, the effects of different aggregation operators on multi-rule-base decision-making are examined in a navigation control problem for mobile robots.

  5. A User Interface for Multiple Retrieval Systems.

    ERIC Educational Resources Information Center

    Teskey, Niall; And Others

    1987-01-01

    Reviews current systems designed to help end-users search online databases without the assistance of an intermediary and describes a prototype system which emulates the Deco (the text storage and retrieval system used by Unilever) interface on Dialog and Data-Star. Initial trials of the prototype system are reported. (15 references) (MES)

  6. The hierarchical algorithms--theory and applications

    NASA Astrophysics Data System (ADS)

    Su, Zheng-Yao

    Monte Carlo simulations are one of the most important numerical techniques for investigating statistical physical systems. Among these systems, spin models are a typical example which also play an essential role in constructing the abstract mechanism for various complex systems. Unfortunately, traditional Monte Carlo algorithms are afflicted with "critical slowing down" near continuous phase transitions and the efficiency of the Monte Carlo simulation goes to zero as the size of the lattice is increased. To combat critical slowing down, a very different type of collective-mode algorithm, in contrast to the traditional single-spin-flipmode, was proposed by Swendsen and Wang in 1987 for Potts spin models. Since then, there has been an explosion of work attempting to understand, improve, or generalize it. In these so-called "cluster" algorithms, clusters of spin are regarded as one template and are updated at each step of the Monte Carlo procedure. In implementing these algorithms the cluster labeling is a major time-consuming bottleneck and is also isomorphic to the problem of computing connected components of an undirected graph seen in other application areas, such as pattern recognition.A number of cluster labeling algorithms for sequential computers have long existed. However, the dynamic irregular nature of clusters complicates the task of finding good parallel algorithms and this is particularly true on SIMD (single-instruction-multiple-data machines. Our design of the Hierarchical Cluster Labeling Algorithm aims at alleviating this problem by building a hierarchical structure on the problem domain and by incorporating local and nonlocal communication schemes. We present an estimate for the computational complexity of cluster labeling and prove the key features of this algorithm (such as lower computational complexity, data locality, and easy implementation) compared with the methods formerly known. In particular, this algorithm can be viewed as a generalized

  7. Method and system of integrating information from multiple sources

    DOEpatents

    Alford, Francine A.; Brinkerhoff, David L.

    2006-08-15

    A system and method of integrating information from multiple sources in a document centric application system. A plurality of application systems are connected through an object request broker to a central repository. The information may then be posted on a webpage. An example of an implementation of the method and system is an online procurement system.

  8. Multiple IMU system development, volume 1

    NASA Technical Reports Server (NTRS)

    Landey, M.; Mckern, R.

    1974-01-01

    A redundant gimballed inertial system is described. System requirements and mechanization methods are defined and hardware and software development is described. Failure detection and isolation algorithms are presented and technology achievements described. Application of the system as a test tool for shuttle avionics concepts is outlined.

  9. Dynamical configurations of celestial systems comprised of multiple irregular bodies

    NASA Astrophysics Data System (ADS)

    Jiang, Yu; Zhang, Yun; Baoyin, Hexi; Li, Junfeng

    2016-09-01

    This manuscript considers the main features of the nonlinear dynamics of multiple irregular celestial body systems. The gravitational potential, static electric potential, and magnetic potential are considered. Based on the three established potentials, we show that three conservative values exist for this system, including a Jacobi integral. The equilibrium conditions for the system are derived and their stability analyzed. The equilibrium conditions of a celestial system comprised of n irregular bodies are reduced to 12n - 9 equations. The dynamical results are applied to simulate the motion of multiple-asteroid systems. The simulation is useful for the study of the stability of multiple irregular celestial body systems and for the design of spacecraft orbits to triple-asteroid systems discovered in the solar system. The dynamical configurations of the five triple-asteroid systems 45 Eugenia, 87 Sylvia, 93 Minerva, 216 Kleopatra, and 136617 1994CC, and the six-body system 134340 Pluto are calculated and analyzed.

  10. Multiple system modelling of waste management.

    PubMed

    Eriksson, Ola; Bisaillon, Mattias

    2011-12-01

    Due to increased environmental awareness, planning and performance of waste management has become more and more complex. Therefore waste management has early been subject to different types of modelling. Another field with long experience of modelling and systems perspective is energy systems. The two modelling traditions have developed side by side, but so far there are very few attempts to combine them. Waste management systems can be linked together with energy systems through incineration plants. The models for waste management can be modelled on a quite detailed level whereas surrounding systems are modelled in a more simplistic way. This is a problem, as previous studies have shown that assumptions on the surrounding system often tend to be important for the conclusions. In this paper it is shown how two models, one for the district heating system (MARTES) and another one for the waste management system (ORWARE), can be linked together. The strengths and weaknesses with model linking are discussed when compared to simplistic assumptions on effects in the energy and waste management systems. It is concluded that the linking of models will provide a more complete, correct and credible picture of the consequences of different simultaneous changes in the systems. The linking procedure is easy to perform and also leads to activation of project partners. However, the simulation procedure is a bit more complicated and calls for the ability to run both models.

  11. Multiple system modelling of waste management

    SciTech Connect

    Eriksson, Ola; Bisaillon, Mattias

    2011-12-15

    Highlights: > Linking of models will provide a more complete, correct and credible picture of the systems. > The linking procedure is easy to perform and also leads to activation of project partners. > The simulation procedure is a bit more complicated and calls for the ability to run both models. - Abstract: Due to increased environmental awareness, planning and performance of waste management has become more and more complex. Therefore waste management has early been subject to different types of modelling. Another field with long experience of modelling and systems perspective is energy systems. The two modelling traditions have developed side by side, but so far there are very few attempts to combine them. Waste management systems can be linked together with energy systems through incineration plants. The models for waste management can be modelled on a quite detailed level whereas surrounding systems are modelled in a more simplistic way. This is a problem, as previous studies have shown that assumptions on the surrounding system often tend to be important for the conclusions. In this paper it is shown how two models, one for the district heating system (MARTES) and another one for the waste management system (ORWARE), can be linked together. The strengths and weaknesses with model linking are discussed when compared to simplistic assumptions on effects in the energy and waste management systems. It is concluded that the linking of models will provide a more complete, correct and credible picture of the consequences of different simultaneous changes in the systems. The linking procedure is easy to perform and also leads to activation of project partners. However, the simulation procedure is a bit more complicated and calls for the ability to run both models.

  12. Dynamics of Kepler's Multiple Planet Systems

    NASA Astrophysics Data System (ADS)

    Lissauer, Jack J.; Kepler Science Team

    2012-05-01

    Among the 1800 Kepler targets that have candidate planets, 20% have two or more candidate planets. While most of these objects have not yet been confirmed as true planets, several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Virtually all candidate systems are stable, as tested by numerical integrations (assuming a nominal mass-radius relationship). Statistical studies performed on these candidates reveal a great deal about the architecture of planetary systems, including the typical spacing of orbits and flatness of planetary systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance.

  13. Hierarchical distance-based fuzzy approach to evaluate urban water supply systems in a semi-arid region.

    PubMed

    Yekta, Tahereh Sadeghi; Khazaei, Mohammad; Nabizadeh, Ramin; Mahvi, Amir Hossein; Nasseri, Simin; Yari, Ahmad Reza

    2015-01-01

    Hierarchical distance-based fuzzy multi-criteria group decision making was served as a tool to evaluate the drinking water supply systems of Qom, a semi-arid city located in central part of Iran. A list of aspects consisting of 6 criteria and 35 sub-criteria were evaluated based on a linguistic term set by five decision-makers. Four water supply alternatives including "Public desalinated distribution system", "PET Bottled Drinking Water", "Private desalinated water suppliers" and "Household desalinated water units" were assessed based on criteria and sub-criteria. Data were aggregated and normalized to apply Performance Ratings of Alternatives. Also, the Performance Ratings of Alternatives were aggregated again to achieve the Aggregate Performance Ratings. The weighted distances from ideal solution and anti-ideal solution were calculated after secondary normalization. The proximity of each alternative to the ideal solution was determined as the final step. The alternatives were ranked based on the magnitude of ideal solutions. Results showed that "Public desalinated distribution system" was the most appropriate alternative to supply the drinking needs of Qom population. Also, "PET Bottled Drinking Water" was the second acceptable option. A novel classification of alternatives to satisfy the drinking water requirements was proposed which is applicable for the other cities located in semi-arid regions of Iran. The health issues were considered as independent criterion, distinct from the environmental issues. The constraints of high-tech alternatives were also considered regarding to the level of dependency on overseas.

  14. Hierarchical distance-based fuzzy approach to evaluate urban water supply systems in a semi-arid region.

    PubMed

    Yekta, Tahereh Sadeghi; Khazaei, Mohammad; Nabizadeh, Ramin; Mahvi, Amir Hossein; Nasseri, Simin; Yari, Ahmad Reza

    2015-01-01

    Hierarchical distance-based fuzzy multi-criteria group decision making was served as a tool to evaluate the drinking water supply systems of Qom, a semi-arid city located in central part of Iran. A list of aspects consisting of 6 criteria and 35 sub-criteria were evaluated based on a linguistic term set by five decision-makers. Four water supply alternatives including "Public desalinated distribution system", "PET Bottled Drinking Water", "Private desalinated water suppliers" and "Household desalinated water units" were assessed based on criteria and sub-criteria. Data were aggregated and normalized to apply Performance Ratings of Alternatives. Also, the Performance Ratings of Alternatives were aggregated again to achieve the Aggregate Performance Ratings. The weighted distances from ideal solution and anti-ideal solution were calculated after secondary normalization. The proximity of each alternative to the ideal solution was determined as the final step. The alternatives were ranked based on the magnitude of ideal solutions. Results showed that "Public desalinated distribution system" was the most appropriate alternative to supply the drinking needs of Qom population. Also, "PET Bottled Drinking Water" was the second acceptable option. A novel classification of alternatives to satisfy the drinking water requirements was proposed which is applicable for the other cities located in semi-arid regions of Iran. The health issues were considered as independent criterion, distinct from the environmental issues. The constraints of high-tech alternatives were also considered regarding to the level of dependency on overseas. PMID:26221535

  15. Supporting multiple control systems at Fermilab

    SciTech Connect

    Nicklaus, Dennis J.; /Fermilab

    2009-10-01

    The Fermilab control system, ACNET, is used for controlling the Tevatron and all of its pre-accelerators. However, other smaller experiments at Fermilab have been using different controls systems, in particular DOOCS and EPICS. This paper reports some of the steps taken at Fermilab to integrate support for these outside systems. We will describe specific tools that we have built or adapted to facilitate interaction between the architectures. We also examine some of the difficulties that arise from managing this heterogeneous environment. Incompatibilities as well as common elements will be described.

  16. Seismic isolation systems with distinct multiple frequencies

    DOEpatents

    Wu, Ting-shu; Seidensticker, Ralph W.

    1990-01-01

    A method and apparatus for isolating a building or other structure from smic vibratory motion which provides increased assurance that large horizontal motion of the structure will not occur than is provided by other isolation systems. Increased assurance that large horizontal motion will not occur is achieved by providing for change of the natural frequency of the support and structure system in response to displacement of the structure beyond a predetermined value. The natural frequency of the support and structure system may be achieved by providing for engaging and disengaging of the structure and some supporting members in response to motion of the supported structure.

  17. Multiple-laser-energy detection system

    NASA Technical Reports Server (NTRS)

    Jarrett, O., Jr.; Northam, G. B.

    1977-01-01

    Technique monitors energy output of each of four sequentially-pulsed dye lasers for the Airborne LIDAR Oceanographic Probing Experiment system. Fiber optics attached to output mirrors transmit optical signal proportional to output energy.

  18. Adaptable Transponder for Multiple Telemetry Systems

    NASA Technical Reports Server (NTRS)

    Sims, William Herbert, III (Inventor); Varnavas, Kosta A. (Inventor)

    2014-01-01

    The present invention is a stackable telemetry circuit board for use in telemetry systems for satellites and other purposes. The present invention incorporates previously-qualified interchangeable circuit boards, or "decks," that perform functions such as power, signal receiving and transmission, and processing. Each deck is adapted to serve a range of telemetry applications. This provides flexibility in the construction of the stackable telemetry circuit board and significantly reduces the cost and time necessary to develop a telemetry system.

  19. A Decision Support System for Solving Multiple Criteria Optimization Problems

    ERIC Educational Resources Information Center

    Filatovas, Ernestas; Kurasova, Olga

    2011-01-01

    In this paper, multiple criteria optimization has been investigated. A new decision support system (DSS) has been developed for interactive solving of multiple criteria optimization problems (MOPs). The weighted-sum (WS) approach is implemented to solve the MOPs. The MOPs are solved by selecting different weight coefficient values for the criteria…

  20. The Use of Multiple Communication in Systemic Couples Therapy.

    ERIC Educational Resources Information Center

    Keeney, Bradford P.; Siegel, Stanley

    1986-01-01

    Presents a clinical technique for working with troubled couples based on a particular theory of multiple communication in therapy. The technique, a "systemic couples reversal," prescribes a way of managing the multiple communications of stability, change, and meaningful Rorschach. Provides a theoretical map, clinical procedure, and clinical case…

  1. Distributed PACS using distributed file system with hierarchical meta data servers.

    PubMed

    Hiroyasu, Tomoyuki; Minamitani, Yoshiyuki; Miki, Mitsunori; Yokouchi, Hisatake; Yoshimi, Masato

    2012-01-01

    In this research, we propose a new distributed PACS (Picture Archiving and Communication Systems) which is available to integrate several PACSs that exist in each medical institution. The conventional PACS controls DICOM file into one data-base. On the other hand, in the proposed system, DICOM file is separated into meta data and image data and those are stored individually. Using this mechanism, since file is not always accessed the entire data, some operations such as finding files, changing titles, and so on can be performed in high-speed. At the same time, as distributed file system is utilized, accessing image files can also achieve high-speed access and high fault tolerant. The introduced system has a more significant point. That is the simplicity to integrate several PACSs. In the proposed system, only the meta data servers are integrated and integrated system can be constructed. This system also has the scalability of file access with along to the number of file numbers and file sizes. On the other hand, because meta-data server is integrated, the meta data server is the weakness of this system. To solve this defect, hieratical meta data servers are introduced. Because of this mechanism, not only fault--tolerant ability is increased but scalability of file access is also increased. To discuss the proposed system, the prototype system using Gfarm was implemented. For evaluating the implemented system, file search operating time of Gfarm and NFS were compared.

  2. Software simulator for multiple computer simulation system

    NASA Technical Reports Server (NTRS)

    Ogrady, E. P.

    1983-01-01

    A description is given of the structure and use of a computer program that simulates the operation of a parallel processor simulation system. The program is part of an investigation to determine algorithms that are suitable for simulating continous systems on a parallel processor configuration. The simulator is designed to accurately simulate the problem-solving phase of a simulation study. Care has been taken to ensure the integrity and correctness of data exchanges and to correctly sequence periods of computation and periods of data exchange. It is pointed out that the functions performed during a problem-setup phase or a reset phase are not simulated. In particular, there is no attempt to simulate the downloading process that loads object code into the local, transfer, and mapping memories of processing elements or the memories of the run control processor and the system control processor. The main program of the simulator carries out some problem-setup functions of the system control processor in that it requests the user to enter values for simulation system parameters and problem parameters. The method by which these values are transferred to the other processors, however, is not simulated.

  3. Resilient 3D hierarchical architected metamaterials.

    PubMed

    Meza, Lucas R; Zelhofer, Alex J; Clarke, Nigel; Mateos, Arturo J; Kochmann, Dennis M; Greer, Julia R

    2015-09-15

    Hierarchically designed structures with architectural features that span across multiple length scales are found in numerous hard biomaterials, like bone, wood, and glass sponge skeletons, as well as manmade structures, like the Eiffel Tower. It has been hypothesized that their mechanical robustness and damage tolerance stem from sophisticated ordering within the constituents, but the specific role of hierarchy remains to be fully described and understood. We apply the principles of hierarchical design to create structural metamaterials from three material systems: (i) polymer, (ii) hollow ceramic, and (iii) ceramic-polymer composites that are patterned into self-similar unit cells in a fractal-like geometry. In situ nanomechanical experiments revealed (i) a nearly theoretical scaling of structural strength and stiffness with relative density, which outperforms existing nonhierarchical nanolattices; (ii) recoverability, with hollow alumina samples recovering up to 98% of their original height after compression to ≥ 50% strain; (iii) suppression of brittle failure and structural instabilities in hollow ceramic hierarchical nanolattices; and (iv) a range of deformation mechanisms that can be tuned by changing the slenderness ratios of the beams. Additional levels of hierarchy beyond a second order did not increase the strength or stiffness, which suggests the existence of an optimal degree of hierarchy to amplify resilience. We developed a computational model that captures local stress distributions within the nanolattices under compression and explains some of the underlying deformation mechanisms as well as validates the measured effective stiffness to be interpreted as a metamaterial property.

  4. Resilient 3D hierarchical architected metamaterials

    PubMed Central

    Meza, Lucas R.; Zelhofer, Alex J.; Clarke, Nigel; Mateos, Arturo J.; Kochmann, Dennis M.; Greer, Julia R.

    2015-01-01

    Hierarchically designed structures with architectural features that span across multiple length scales are found in numerous hard biomaterials, like bone, wood, and glass sponge skeletons, as well as manmade structures, like the Eiffel Tower. It has been hypothesized that their mechanical robustness and damage tolerance stem from sophisticated ordering within the constituents, but the specific role of hierarchy remains to be fully described and understood. We apply the principles of hierarchical design to create structural metamaterials from three material systems: (i) polymer, (ii) hollow ceramic, and (iii) ceramic–polymer composites that are patterned into self-similar unit cells in a fractal-like geometry. In situ nanomechanical experiments revealed (i) a nearly theoretical scaling of structural strength and stiffness with relative density, which outperforms existing nonhierarchical nanolattices; (ii) recoverability, with hollow alumina samples recovering up to 98% of their original height after compression to ≥50% strain; (iii) suppression of brittle failure and structural instabilities in hollow ceramic hierarchical nanolattices; and (iv) a range of deformation mechanisms that can be tuned by changing the slenderness ratios of the beams. Additional levels of hierarchy beyond a second order did not increase the strength or stiffness, which suggests the existence of an optimal degree of hierarchy to amplify resilience. We developed a computational model that captures local stress distributions within the nanolattices under compression and explains some of the underlying deformation mechanisms as well as validates the measured effective stiffness to be interpreted as a metamaterial property. PMID:26330605

  5. Resilient 3D hierarchical architected metamaterials.

    PubMed

    Meza, Lucas R; Zelhofer, Alex J; Clarke, Nigel; Mateos, Arturo J; Kochmann, Dennis M; Greer, Julia R

    2015-09-15

    Hierarchically designed structures with architectural features that span across multiple length scales are found in numerous hard biomaterials, like bone, wood, and glass sponge skeletons, as well as manmade structures, like the Eiffel Tower. It has been hypothesized that their mechanical robustness and damage tolerance stem from sophisticated ordering within the constituents, but the specific role of hierarchy remains to be fully described and understood. We apply the principles of hierarchical design to create structural metamaterials from three material systems: (i) polymer, (ii) hollow ceramic, and (iii) ceramic-polymer composites that are patterned into self-similar unit cells in a fractal-like geometry. In situ nanomechanical experiments revealed (i) a nearly theoretical scaling of structural strength and stiffness with relative density, which outperforms existing nonhierarchical nanolattices; (ii) recoverability, with hollow alumina samples recovering up to 98% of their original height after compression to ≥ 50% strain; (iii) suppression of brittle failure and structural instabilities in hollow ceramic hierarchical nanolattices; and (iv) a range of deformation mechanisms that can be tuned by changing the slenderness ratios of the beams. Additional levels of hierarchy beyond a second order did not increase the strength or stiffness, which suggests the existence of an optimal degree of hierarchy to amplify resilience. We developed a computational model that captures local stress distributions within the nanolattices under compression and explains some of the underlying deformation mechanisms as well as validates the measured effective stiffness to be interpreted as a metamaterial property. PMID:26330605

  6. Multiple strategies of reasoning for expert systems

    SciTech Connect

    Yao Yuchuan; Kulikowski, C.A.

    1983-01-01

    In expert systems the heuristics used for combining the weight of evidence can be based on probabilistic, fuzzy set, or subjective confidence factors. Although the underlying assumptions for each of the methods differ, it can be shown that there are correspondences between them and that it is possible to develop a model of expert reasoning for medical consultation using any one of the methods. The authors have developed a system for representing expert knowledge, called ESMES, which is an outgrowth of the expert scheme developed earlier at Rutgers. ESMES allows the use of alternative strategies in the solution of a consultation problem. The authors report on the performance of ESMES for a prototype glaucoma consultation model, using reasoning mechanisms similar to those of the expert, MYCIN, Internist I, and Prospector systems. 9 references.

  7. Optoelectronic System Measures Distances to Multiple Targets

    NASA Technical Reports Server (NTRS)

    Liebe, Carl Christian; Abramovici, Alexander; Bartman, Randall; Chapsky, Jacob; Schmalz, John; Coste, Keith; Litty, Edward; Lam, Raymond; Jerebets, Sergei

    2007-01-01

    An optoelectronic metrology apparatus now at the laboratory-prototype stage of development is intended to repeatedly determine distances of as much as several hundred meters, at submillimeter accuracy, to multiple targets in rapid succession. The underlying concept of optoelectronic apparatuses that can measure distances to targets is not new; such apparatuses are commonly used in general surveying and machining. However, until now such apparatuses have been, variously, constrained to (1) a single target or (2) multiple targets with a low update rate and a requirement for some a priori knowledge of target geometry. When fully developed, the present apparatus would enable measurement of distances to more than 50 targets at an update rate greater than 10 Hz, without a requirement for a priori knowledge of target geometry. The apparatus (see figure) includes a laser ranging unit (LRU) that includes an electronic camera (photo receiver), the field of view of which contains all relevant targets. Each target, mounted at a fiducial position on an object of interest, consists of a small lens at the output end of an optical fiber that extends from the object of interest back to the LRU. For each target and its optical fiber, there is a dedicated laser that is used to illuminate the target via the optical fiber. The targets are illuminated, one at a time, with laser light that is modulated at a frequency of 10.01 MHz. The modulated laser light is emitted by the target, from where it returns to the camera (photodetector), where it is detected. Both the outgoing and incoming 10.01-MHz laser signals are mixed with a 10-MHz local-oscillator to obtain beat notes at 10 kHz, and the difference between the phases of the beat notes is measured by a phase meter. This phase difference serves as a measure of the total length of the path traveled by light going out through the optical fiber and returning to the camera (photodetector) through free space. Because the portion of the path

  8. Exoplanet orbital eccentricity: multiplicity relation and the Solar System.

    PubMed

    Limbach, Mary Anne; Turner, Edwin L

    2015-01-01

    The known population of exoplanets exhibits a much wider range of orbital eccentricities than Solar System planets and has a much higher average eccentricity. These facts have been widely interpreted to indicate that the Solar System is an atypical member of the overall population of planetary systems. We report here on a strong anticorrelation of orbital eccentricity with multiplicity (number of planets in the system) among cataloged radial velocity (RV) systems. The mean, median, and rough distribution of eccentricities of Solar System planets fits an extrapolation of this anticorrelation to the eight-planet case rather precisely despite the fact that no more than two Solar System planets would be detectable with RV data comparable to that in the exoplanet sample. Moreover, even if regarded as a single or double planetary system, the Solar System lies in a reasonably heavily populated region of eccentricity-multiplicity space. Thus, the Solar System is not anomalous among known exoplanetary systems with respect to eccentricities when its multiplicity is taken into account. Specifically, as the multiplicity of a system increases, the eccentricity decreases roughly as a power law of index -1.20. A simple and plausible but ad hoc and model-dependent interpretation of this relationship implies that ∼ 80% of the one-planet and 25% of the two-planet systems in our sample have additional, as yet undiscovered, members but that systems of higher observed multiplicity are largely complete (i.e., relatively rarely contain additional undiscovered planets). If low eccentricities indeed favor high multiplicities, habitability may be more common in systems with a larger number of planets. PMID:25512527

  9. Exoplanet orbital eccentricity: multiplicity relation and the Solar System.

    PubMed

    Limbach, Mary Anne; Turner, Edwin L

    2015-01-01

    The known population of exoplanets exhibits a much wider range of orbital eccentricities than Solar System planets and has a much higher average eccentricity. These facts have been widely interpreted to indicate that the Solar System is an atypical member of the overall population of planetary systems. We report here on a strong anticorrelation of orbital eccentricity with multiplicity (number of planets in the system) among cataloged radial velocity (RV) systems. The mean, median, and rough distribution of eccentricities of Solar System planets fits an extrapolation of this anticorrelation to the eight-planet case rather precisely despite the fact that no more than two Solar System planets would be detectable with RV data comparable to that in the exoplanet sample. Moreover, even if regarded as a single or double planetary system, the Solar System lies in a reasonably heavily populated region of eccentricity-multiplicity space. Thus, the Solar System is not anomalous among known exoplanetary systems with respect to eccentricities when its multiplicity is taken into account. Specifically, as the multiplicity of a system increases, the eccentricity decreases roughly as a power law of index -1.20. A simple and plausible but ad hoc and model-dependent interpretation of this relationship implies that ∼ 80% of the one-planet and 25% of the two-planet systems in our sample have additional, as yet undiscovered, members but that systems of higher observed multiplicity are largely complete (i.e., relatively rarely contain additional undiscovered planets). If low eccentricities indeed favor high multiplicities, habitability may be more common in systems with a larger number of planets.

  10. Exoplanet orbital eccentricity: Multiplicity relation and the Solar System

    PubMed Central

    Limbach, Mary Anne; Turner, Edwin L.

    2015-01-01

    The known population of exoplanets exhibits a much wider range of orbital eccentricities than Solar System planets and has a much higher average eccentricity. These facts have been widely interpreted to indicate that the Solar System is an atypical member of the overall population of planetary systems. We report here on a strong anticorrelation of orbital eccentricity with multiplicity (number of planets in the system) among cataloged radial velocity (RV) systems. The mean, median, and rough distribution of eccentricities of Solar System planets fits an extrapolation of this anticorrelation to the eight-planet case rather precisely despite the fact that no more than two Solar System planets would be detectable with RV data comparable to that in the exoplanet sample. Moreover, even if regarded as a single or double planetary system, the Solar System lies in a reasonably heavily populated region of eccentricity−multiplicity space. Thus, the Solar System is not anomalous among known exoplanetary systems with respect to eccentricities when its multiplicity is taken into account. Specifically, as the multiplicity of a system increases, the eccentricity decreases roughly as a power law of index –1.20. A simple and plausible but ad hoc and model-dependent interpretation of this relationship implies that ∼80% of the one-planet and 25% of the two-planet systems in our sample have additional, as yet undiscovered, members but that systems of higher observed multiplicity are largely complete (i.e., relatively rarely contain additional undiscovered planets). If low eccentricities indeed favor high multiplicities, habitability may be more common in systems with a larger number of planets. PMID:25512527

  11. Multiple Viewpoints System/ Software Engineering for Space

    NASA Astrophysics Data System (ADS)

    Blondelle, Gael; Panunzio, Marco; Pequery, Jerome; Bats, Melanie; Garcia, Gerald; Brun, Cedric

    2013-08-01

    This paper presents a return of experience on using viewpoint-oriented modeling to design on-board software for satellites. First, we demonstrate the interest of integrating heterogeneous viewpoints in a tool to cover the development process of an embedded system. Then, we recall the Space Component Model, its implementation with Obeo Designer, and the capability to extend it with specific purpose Domain Specific Languages. Last, we expose further viewpoints that could be implemented to address new aspects like safety or interoperability.

  12. Belt-hierarchic structure of th ring, satellite and planet systems: prediction S/2001 U1 and others objects in Solar system

    NASA Astrophysics Data System (ADS)

    Barkin, Yu. V.

    2003-04-01

    BELT-HIERARCHIC STRUCTURE OF THE RING, SATELLITE AND PLANET SYSTEMS: PREDICTION S/2001 U1 AND OTHERS OBJECTS IN SOLAR SYSTEM Yu.V.Barkin Sternberg Astronomical Institute, Moscow, Russia, barkin@sai.msu.ru Structure regularities of the planet and satellite systems have been studied. Statistic analysis of the distribution of the major semi-axes of the orbits of the planets, comets and centaurs of the Solar system, satellite and ring systems of Jupiter, Saturn, Neptune and Uran, exoplanet systems of the pulsars PSR 1257+12, PSR 1828-11 and of the main consequence star Ups And was fulfilled. The following empirical regularities were described [1]: 1) the bodies of systems are combined into hierarchic groups and main from them combine 5 companions; 2) differences of the major semi-axes of the neighboring orbits for bodies of every group are constant; 4) for main neighboring hierarchic group these distances are distinguished in 6 times increasing to external grope; 5) the filling of the gropes and some present changes in their structure are caused by the past catastrophes in corresponding systems. The special method of reconstruction of the catastrophes which had place in the life of the Solar system (SS) was developed. Suggested method has let us to explain uniformly observed values of the major semi-axes and average values of eccentricities of the planets. In particular the Pancul’s hypothesis about Jupiter formation from two giant protoplanets (Jupiter I and Jupiter II) was confirmed. The new empirical law of the filling of the orbits of the regular groups of the planets or satellites (or rings structures) of the hierarchic ordered systems of celestial bodies was established. It was shown that sum number of bodies is proportional to the value of catastrophic value of the eccentricities which are same for first, second ,.... and fifth orbits of all gropes. The theoretical numbers of bodies for pointed orbits practically coincide with their observed numbers in main

  13. ARCHITECTURE AND DYNAMICS OF KEPLER'S CANDIDATE MULTIPLE TRANSITING PLANET SYSTEMS

    SciTech Connect

    Lissauer, Jack J.; Jenkins, Jon M.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B.; Ragozzine, Darin; Holman, Matthew J.; Carter, Joshua A.; Fabrycky, Daniel C.; Fortney, Jonathan J.; Steffen, Jason H.; Ford, Eric B.; Shporer, Avi; Rowe, Jason F.; Quintana, Elisa V.; Caldwell, Douglas A.; Ciardi, David; Gautier, Thomas N. III; and others

    2011-11-01

    About one-third of the {approx}1200 transiting planet candidates detected in the first four months of Kepler data are members of multiple candidate systems. There are 115 target stars with two candidate transiting planets, 45 with three, 8 with four, and 1 each with five and six. We characterize the dynamical properties of these candidate multi-planet systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean-motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. We find that virtually all candidate systems are stable, as tested by numerical integrations that assume a nominal mass-radius relationship. Several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Using the observed multiplicity frequencies, we find that a single population of planetary systems that matches the higher multiplicities underpredicts the number of singly transiting systems. We provide constraints on the true multiplicity and mutual inclination distribution of the multi-candidate systems, revealing a population of systems with multiple super-Earth-size and Neptune-size planets with low to moderate mutual inclinations.

  14. Under-sampling in a Multiple-Channel Laser Vibrometry System

    SciTech Connect

    Corey, Jordan

    2007-03-01

    Laser vibrometry is a technique used to detect vibrations on objects using the interference of coherent light with itself. Most vibrometry systems process only one target location at a time, but processing multiple locations simultaneously provides improved detection capabilities. Traditional laser vibrometry systems employ oversampling to sample the incoming modulated-light signal, however as the number of channels increases in these systems, certain issues arise such a higher computational cost, excessive heat, increased power requirements, and increased component cost. This thesis describes a novel approach to laser vibrometry that utilizes undersampling to control the undesirable issues associated with over-sampled systems. Undersampling allows for significantly less samples to represent the modulated-light signals, which offers several advantages in the overall system design. These advantages include an improvement in thermal efficiency, lower processing requirements, and a higher immunity to the relative intensity noise inherent in laser vibrometry applications. A unique feature of this implementation is the use of a parallel architecture to increase the overall system throughput. This parallelism is realized using a hierarchical multi-channel architecture based on off-the-shelf programmable logic devices (PLDs).

  15. Advanced multiple access concepts in mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Ananasso, Fulvio

    1990-01-01

    Some multiple access strategies for Mobile Satellite Systems (MSS) are discussed. These strategies were investigated in the context of three separate studies conducted for the International Maritime Satellite Organization (INMARSAT) and the European Space Agency (ESA). Satellite-Switched Frequency Division Multiple Access (SS-FDMA), Code Division Multiple Access (CDMA), and Frequency-Addressable Beam architectures are addressed, discussing both system and technology aspects and outlining advantages and drawbacks of either solution with associated relevant hardware issues. An attempt is made to compare the considered option from the standpoint of user terminal/space segment complexity, synchronization requirements, spectral efficiency, and interference rejection.

  16. MULTIPLE PROJECTIONS SYSTEM (MPS): USER'S MANUAL VERSION 2.0

    EPA Science Inventory

    The document is a user's manual for Multiple Projections System (MPS) Version 2.0, based on the 3% reasonable further progress (RFP) tracking system that was developed in FY92/FY93. The 3% RFP tracking system is a Windows application, and enhancements to convert the 3% RFP track...

  17. The NP Draconii Multiple Star System

    NASA Astrophysics Data System (ADS)

    Castelaz, Michael W.; Barker, Thurburn; McNaughton, Abby; Robertson, Rachel; Smith, Matt

    2016-01-01

    Otero and Dubovsky used the ASAS-3 (Pojmanski 2002), Hipparcos (Perryman et al 1997) and Northern Sky Variability Survey (NSVS; Wozniak et al 2004) databases to determine elements for 80 eclipsing binaries. NP Draconii (NSV 22984) was identified by Otero and Dubovsky (IBVS Number 5557, 2004) as a possible Algol type variable with an ephemeris of HJD Min I = 2448604.780+3.10886E days based on 84 observations over 326 days with about 2 to 4 observations on any one night. We decided to further refine the ephemeris and observe NP Dra in VRI filters, with the goal of determining the elements of the system.NP Dra is a V = 9.0 system located at J2000 = 17h 35m 16s and +55d 00' 12". We observed NP Dra August 2, 3 and September 15, 16, 17, 18, and 19 2015 UT using the Pisgah Astronomical Research Institute 0.4-m telescope in V, R, and I with 20 second exposure times in each filter. Observations in each filter were repeated about every 3 minutes each night of observing.From our light curves we determined the period using the Date Compensated Discrete Fourier Transform function (Ferraz-Mello 1981) which is part of the open source code VSTAR (AAVSO). The period derived from the observations is 2.2755 days. Superimposed on this period is another period of 0.6398 days. We will present the V, R, and I light curves, period determination and implication

  18. Multiple fiber Bragg grating sensor system using code-division multiple access.

    PubMed

    Lee, Hojoon

    2002-09-01

    We propose and demonstrate experimentally a multiple fiber Bragg grating sensor system that uses a LED as a light source and adapts the code-division multiple access method to separate individual sensor signals. We measured static and dynamic strains and cross-talk levels among sensor signals. With our proposed scheme, a low-cost sensor system can be designed with a fast response speed. Cross-talk levels between sensor signals are found to be below the -30-dB level.

  19. Single and Multiple Visual Systems in Arthropods

    PubMed Central

    Wald, George

    1968-01-01

    Extraction of two visual pigments from crayfish eyes prompted an electrophysiological examination of the role of visual pigments in the compound eyes of six arthropods. The intact animals were used; in crayfishes isolated eyestalks also. Thresholds were measured in terms of the absolute or relative numbers of photons per flash at various wavelengths needed to evoke a constant amplitude of electroretinogram, usually 50 µv. Two species of crayfish, as well as the green crab, possess blue- and red-sensitive receptors apparently arranged for color discrimination. In the northern crayfish, Orconectes virilis, the spectral sensitivity of the dark-adapted eye is maximal at about 550 mµ, and on adaptation to bright red or blue lights breaks into two functions with λmax respectively at about 435 and 565 mµ, apparently emanating from different receptors. The swamp crayfish, Procambarus clarkii, displays a maximum sensitivity when dark-adapted at about 570 mµ, that breaks on color adaptation into blue- and red-sensitive functions with λmax about 450 and 575 mµ, again involving different receptors. Similarly the green crab, Carcinides maenas, presents a dark-adapted sensitivity maximal at about 510 mµ that divides on color adaptation into sensitivity curves maximal near 425 and 565 mµ. Each of these organisms thus possesses an apparatus adequate for at least two-color vision, resembling that of human green-blinds (deuteranopes). The visual pigments of the red-sensitive systems have been extracted from the crayfish eyes. The horse-shoe crab, Limulus, and the lobster each possesses a single visual system, with λmax respectively at 520 and 525 mµ. Each of these is invariant with color adaptation. In each case the visual pigment had already been identified in extracts. The spider crab, Libinia emarginata, presents another variation. It possesses two visual systems apparently differentiated, not for color discrimination but for use in dim and bright light, like

  20. A GUI for Modeling Multiple Planet Systems

    NASA Astrophysics Data System (ADS)

    Giguere, Matthew J.; Ader, T.; Barnes, R.; Barranco, J. A.; Fischer, D.

    2009-01-01

    We developed an IDL widget interface (MPF Widget) to model planetary systems using combined astrometric and radial velocity data. MPF Widget drives a Levenberg-Marquardt fitting algorithm to simultaneously fit data for parallax, proper motion and up to seven planets. This visualization tool is helpful for locating good initial guesses that allow the Levenberg-Marquardt fitting algorithm to converge on the global minimum chi squared value. It also includes tools for periodogram analysis and the capability to fit planets sequentially working with the residual data from each preceding model. MPF Widget was developed to test simulated data for the Space Interferometry Mission (SIM) and would be a useful tool for teaching the effects of each Keplerian parameter on observational data. We thank NASA and SIM for supporting this project.

  1. Molecular and mesoscale mechanism for hierarchical self-assembly of dipeptide and porphyrin light-harvesting system.

    PubMed

    Liu, Kai; Kang, Yu; Ma, Guanghui; Möhwald, Helmuth; Yan, Xuehai

    2016-06-22

    A multi-scale theoretical investigation of dipeptide-porphyrin co-assembly systems has been carried out to establish such understanding, where two different types of the dipeptides, dilysine (KK(3+)) and diphenylalanine (FF(+)) are compared on tuning the porphyrin organization. Density functional theory results reveal that the electrostatic attraction between different functional groups has significantly strengthened the hydrogen bonds between them, which are considered as the driving force of the self-assembly at the molecular level. All-atom molecular dynamics (MD) simulation further indicates that the formation of the core-shell nanorods is driven and stabilized by the hydrophobic interaction between dipeptides and negatively charged porphyrin (H2TPPS(2-)), where the packed porphyrins stay inside as the core of the nanorods and the hydrophilic groups (amino- and carboxyl-groups) as the shell. With stronger hydrophobicity, FF(+) is more likely to insert into the porphyrin aggregates and build crosslinks than KK(3+). Moreover, dissipative particle dynamics (DPD) simulation suggests equilibrium morphologies with different dipeptides, where KK(3+)-H2TPPS(2-) assembled in fiber bundles, whereas FF(+)-H2TPPS(2-) assembled as microspheres, corresponding to the different packing behavior in MD simulations. The consistency of these results at different scales is discussed. The method used in this work could be extended for studying similar issues in hierarchical self-assembly of building blocks such biomaterials. PMID:27270974

  2. Hierarchical Nanostructures Self-Assembled from a Mixture System Containing Rod-Coil Block Copolymers and Rigid Homopolymers

    PubMed Central

    Li, Yongliang; Jiang, Tao; Lin, Shaoliang; Lin, Jiaping; Cai, Chunhua; Zhu, Xingyu

    2015-01-01

    Self-assembly behavior of a mixture system containing rod-coil block copolymers and rigid homopolymers was investigated by using Brownian dynamics simulations. The morphologies of formed hierarchical self-assemblies were found to be dependent on the Lennard-Jones (LJ) interaction εRR between rod blocks, lengths of rod and coil blocks in copolymer, and mixture ratio of block copolymers to homopolymers. As the εRR value decreases, the self-assembled structures of mixtures are transformed from an abacus-like structure to a helical structure, to a plain fiber, and finally are broken into unimers. The order parameter of rod blocks was calculated to confirm the structure transition. Through varying the length of rod and coil blocks, the regions of thermodynamic stability of abacus, helix, plain fiber, and unimers were mapped. Moreover, it was discovered that two levels of rod block ordering exist in the helices. The block copolymers are helically wrapped on the homopolymer bundles to form helical string, while the rod blocks are twistingly packed inside the string. In addition, the simulation results are in good agreement with experimental observations. The present work reveals the mechanism behind the formation of helical (experimentally super-helical) structures and may provide useful information for design and preparation of the complex structures. PMID:25965726

  3. Hierarchical Nanostructures Self-Assembled from a Mixture System Containing Rod-Coil Block Copolymers and Rigid Homopolymers

    NASA Astrophysics Data System (ADS)

    Li, Yongliang; Jiang, Tao; Lin, Shaoliang; Lin, Jiaping; Cai, Chunhua; Zhu, Xingyu

    2015-05-01

    Self-assembly behavior of a mixture system containing rod-coil block copolymers and rigid homopolymers was investigated by using Brownian dynamics simulations. The morphologies of formed hierarchical self-assemblies were found to be dependent on the Lennard-Jones (LJ) interaction ɛRR between rod blocks, lengths of rod and coil blocks in copolymer, and mixture ratio of block copolymers to homopolymers. As the ɛRR value decreases, the self-assembled structures of mixtures are transformed from an abacus-like structure to a helical structure, to a plain fiber, and finally are broken into unimers. The order parameter of rod blocks was calculated to confirm the structure transition. Through varying the length of rod and coil blocks, the regions of thermodynamic stability of abacus, helix, plain fiber, and unimers were mapped. Moreover, it was discovered that two levels of rod block ordering exist in the helices. The block copolymers are helically wrapped on the homopolymer bundles to form helical string, while the rod blocks are twistingly packed inside the string. In addition, the simulation results are in good agreement with experimental observations. The present work reveals the mechanism behind the formation of helical (experimentally super-helical) structures and may provide useful information for design and preparation of the complex structures.

  4. Hierarchical nanostructures self-assembled from a mixture system containing rod-coil block copolymers and rigid homopolymers.

    PubMed

    Li, Yongliang; Jiang, Tao; Lin, Shaoliang; Lin, Jiaping; Cai, Chunhua; Zhu, Xingyu

    2015-05-12

    Self-assembly behavior of a mixture system containing rod-coil block copolymers and rigid homopolymers was investigated by using Brownian dynamics simulations. The morphologies of formed hierarchical self-assemblies were found to be dependent on the Lennard-Jones (LJ) interaction εRR between rod blocks, lengths of rod and coil blocks in copolymer, and mixture ratio of block copolymers to homopolymers. As the εRR value decreases, the self-assembled structures of mixtures are transformed from an abacus-like structure to a helical structure, to a plain fiber, and finally are broken into unimers. The order parameter of rod blocks was calculated to confirm the structure transition. Through varying the length of rod and coil blocks, the regions of thermodynamic stability of abacus, helix, plain fiber, and unimers were mapped. Moreover, it was discovered that two levels of rod block ordering exist in the helices. The block copolymers are helically wrapped on the homopolymer bundles to form helical string, while the rod blocks are twistingly packed inside the string. In addition, the simulation results are in good agreement with experimental observations. The present work reveals the mechanism behind the formation of helical (experimentally super-helical) structures and may provide useful information for design and preparation of the complex structures.

  5. In₂S₃/carbon nanofibers/Au ternary synergetic system: hierarchical assembly and enhanced visible-light photocatalytic activity.

    PubMed

    Zhang, Xin; Shao, Changlu; Li, Xinghua; Lu, Na; Wang, Kexin; Miao, Fujun; Liu, Yichun

    2015-01-01

    In this paper, carbon nanofibers (CNFs) were successfully synthesized by electrospinning technique. Next, Au nanoparticles (NPs) were assembled on the electrospun CNFs through in situ reduction method. By using the obtained Au NPs modified CNFs (CNFs/Au) as hard template, the In2S3/CNFs/Au composites were synthesized through hydrothermal technique. The results showed that the super long one-dimensional (1D) CNFs (about 306 nm in average diameter) were well connected to form a nanofibrous network; and, the Au NPs with 18 nm in average diameter and In2S3 nanosheets with 5-10nm in thickness were uniformly grown onto the surface of CNFs. Photocatalytic studies revealed that the In2S3/CNFs/Au composites exhibited highest visible-light photocatalytic activities for the degradation of Rhodamine B (RB) compared with pure In2S3 and In2S3/CNFs. The enhanced photocatalytic activity might arise from the high separation efficiency of photogenerated electron-hole pairs based on the positive synergetic effect between In2S3, CNFs and Au components in this ternary photocatalytic system. Meanwhile, the In2S3/CNFs/Au composites with hierarchical structure possess a strong adsorption ability towards organic dyes, which also contributed to the enhancement of photocatalytic activity. Moreover, the In2S3/CNFs/Au composites could be recycled easily by sedimentation due to their nanofibrous network structure. PMID:25464301

  6. Integrated flight/propulsion control system design based on a decentralized, hierarchical approach

    NASA Technical Reports Server (NTRS)

    Mattern, Duane; Garg, Sanjay; Bullard, Randy

    1989-01-01

    A sample integrated flight/propulsion control system design is presented for the piloted longitiudinal landing task with a modern, statistically unstable fighter aircraft. The design procedure is summarized, the vehicle model used in the sample study is described, and the procedure for partitioning the integrated system is presented along with a description of the subsystems. The high-level airframe performance specifications and control design are presented and the control performance is evaluated. The generation of the low-level (engine) subsystem specifications from the airframe requirements are discussed, and the engine performance specifications are presented along with the subsystem control design. A compensator to accommodate the influence of airframe outputs on the engine subsystem is also considered. Finally, the entire closed loop system performance and stability characteristics are examined.

  7. Remarks on Hierarchic Control for a Linearized Micropolar Fluids System in Moving Domains

    SciTech Connect

    Jesus, Isaías Pereira de

    2015-12-15

    We study a Stackelberg strategy subject to the evolutionary linearized micropolar fluids equations in domains with moving boundaries, considering a Nash multi-objective equilibrium (non necessarily cooperative) for the “follower players” (as is called in the economy field) and an optimal problem for the leader player with approximate controllability objective. We will obtain the following main results: the existence and uniqueness of Nash equilibrium and its characterization, the approximate controllability of the linearized micropolar system with respect to the leader control and the existence and uniqueness of the Stackelberg–Nash problem, where the optimality system for the leader is given.

  8. An efficient key-management scheme for hierarchical access control in e-medicine system.

    PubMed

    Wu, Shuhua; Chen, Kefei

    2012-08-01

    In e-medicine system, the sharing of patients' medical histories scattered among medical institutions through the Internet is highly desirable. The most immediate cryptographic need certainly is an efficient key management method to solve dynamic access problems in a user hierarchy. In this paper, we propose a practical solution for dynamic access problem in a user hierarchy based on hybrid cryptosystems. When compared with Nikooghadam et al.'s scheme proposed most recently, the time complexity and the required storage space is reduced significantly. Moreover, it provides provable security, and is easy to implement. Therefore, our scheme is more suitable for e-medicine system.

  9. An intelligent decomposition approach for efficient design of non-hierarchic systems

    NASA Technical Reports Server (NTRS)

    Bloebaum, Christina L.

    1992-01-01

    The design process associated with large engineering systems requires an initial decomposition of the complex systems into subsystem modules which are coupled through transference of output data. The implementation of such a decomposition approach assumes the ability exists to determine what subsystems and interactions exist and what order of execution will be imposed during the analysis process. Unfortunately, this is quite often an extremely complex task which may be beyond human ability to efficiently achieve. Further, in optimizing such a coupled system, it is essential to be able to determine which interactions figure prominently enough to significantly affect the accuracy of the optimal solution. The ability to determine 'weak' versus 'strong' coupling strengths would aid the designer in deciding which couplings could be permanently removed from consideration or which could be temporarily suspended so as to achieve computational savings with minimal loss in solution accuracy. An approach that uses normalized sensitivities to quantify coupling strengths is presented. The approach is applied to a coupled system composed of analysis equations for verification purposes.

  10. Hierarchical, decentralized control system for large-scale smart-structures

    NASA Astrophysics Data System (ADS)

    Algermissen, Stephan; Fröhlich, Tim; Monner, Hans Peter

    2014-08-01

    Active control of sound and vibration has gained much attention in all kinds of industries in the past decade. Future prospects for maximizing airline passenger comfort are especially promising. The objectives of recent research projects in this area are the reduction of noise transmission through thin walled structures such as fuselages, linings or interior elements. Besides different external noise sources, such as the turbulent boundary layer, rotor or jet noise, the actuator and sensor placement as well as different control concepts are addressed. Mostly, the work is focused on a single panel or section of the fuselage, neglecting the fact that for effective noise reduction the entire fuselage has to be taken into account. Nevertheless, extending the scope of an active system from a single panel to the entire fuselage increases the effort for control hardware dramatically. This paper presents a control concept for large structures using distributed control nodes. Each node has the capability to execute a vibration or noise controller for a specific part or section of the fuselage. For maintenance, controller tuning or performance measurement, all nodes are connected to a host computer via Universal Serial Bus (USB). This topology allows a partitioning and distributing of tasks. The nodes execute the low-level control functions. High-level tasks like maintenance, system identification and control synthesis are operated by the host using streamed data from the nodes. By choosing low-price nodes, a very cost effective way of implementing an active system for large structures is realized. Besides the system identification and controller synthesis on the host computer, a detailed view on the hardware and software concept for the nodes is given. Finally, the results of an experimental test of a system running a robust vibration controller at an active panel demonstrator are shown.

  11. Exoplanet as Third Bodies of Multiple Systems (A Quantization Method)

    NASA Astrophysics Data System (ADS)

    El Fady Morcos, Abd; Awadalla, Nabil; Hanna, Magdy

    2016-07-01

    Third bodies in some multiple systems are considered as exoplanets. Many authors have been expected that, the majority of solar-type stars exist in binary or multiple systems having planets (Duquennoy& Mayor, 1991). The planetary formation in binary systems has become an important issue. In This work, we are aiming to differentiate between the natures of a third bodies, are they stars or a planets. The formula derived by Morcos (2013), has been adapted and used to find the quantum numbers of some third bodies of some multiple stars systems. The observed date of some triple systems, from outer space and in the Interactive Extra-solar Planets Catalog", for W-type , W-subtypes contact binaries, W- Uma binaries eclipsing detached binaries and Algol semidetached types have been used. The expected quantum numbers of the third bodies are obtained. The calculated quantum numbers may be used as indicator for exoplanets.

  12. A pollutant load hierarchical allocation method integrated in an environmental capacity management system for Zhushan Bay, Taihu Lake.

    PubMed

    Liang, Shidong; Jia, Haifeng; Yang, Cong; Melching, Charles; Yuan, Yongping

    2015-11-15

    An environmental capacity management (ECM) system was developed to help practically implement a Total Maximum Daily Load (TMDL) for a key bay in a highly eutrophic lake in China. The ECM system consists of a simulation platform for pollutant load calculation and a pollutant load hierarchical allocation (PLHA) system. The simulation platform was developed by linking the Environmental Fluid Dynamics Code (EFDC) and Water Quality Analysis Simulation Program (WASP). In the PLHA, pollutant loads were allocated top-down in several levels based on characteristics of the pollutant sources. Different allocation methods could be used for the different levels with the advantages of each method combined over the entire allocation. Zhushan Bay of Taihu Lake, one of the most eutrophic lakes in China, was selected as a case study. The allowable loads of total nitrogen, total phosphorus, ammonia, and chemical oxygen demand were found to be 2122.2, 94.9, 1230.4, and 5260.0 t·yr(-1), respectively. The PLHA for the case study consists of 5 levels. At level 0, loads are allocated to those from the lakeshore direct drainage, atmospheric deposition, internal release, and tributary inflows. At level 1 the loads allocated to tributary inflows are allocated to the 3 tributaries. At level 2, the loads allocated to one inflow tributary are allocated to upstream areas and local sources along the tributary. At level 3, the loads allocated to local sources are allocated to the point and non-point sources from different towns. At level 4, the loads allocated to non-point sources in each town are allocated to different villages. Compared with traditional forms of pollutant load allocation methods, PLHA can combine the advantages of different methods which put different priority weights on equity and efficiency, and the PLHA is easy to understand for stakeholders and more flexible to adjust when applied in practical cases. PMID:26172589

  13. Scalable Hierarchical Network Management System for Displaying Network Information in Three Dimensions

    NASA Technical Reports Server (NTRS)

    George, Jude (Inventor); Schlecht, Leslie (Inventor); McCabe, James D. (Inventor); LeKashman, John Jr. (Inventor)

    1998-01-01

    A network management system has SNMP agents distributed at one or more sites, an input output module at each site, and a server module located at a selected site for communicating with input output modules, each of which is configured for both SNMP and HNMP communications. The server module is configured exclusively for HNMP communications, and it communicates with each input output module according to the HNMP. Non-iconified, informationally complete views are provided of network elements to aid in network management.

  14. Implementation of multiple information hiding & real-time extraction system

    NASA Astrophysics Data System (ADS)

    Choi, Jin-Hyug; Kim, Jung-Jin; Cho, Byung-Chul; Lee, Maeng-Ho; Kim, Eun-Soo

    2002-12-01

    In this paper, a new optodigital multiple information hiding and real-time extraction system is suggested. In the process of multiple information hiding, stego keys are generated by combined use of PRS (pseudo-random sequence) and HM (Hadamard matrix) and then, they are used to hide multiple data in an arbitrary cover image without crosstalks. To extract multiple information hidden in the stego image in real-time, a new optical NJTC(nonlinear joint transform correlator)-based extraction system is introduced. In this optical extraction system, both the stego image and each of stego keys are placed at the input plane of the correlator and jointly Fourier transformed. And, the power spectrum of the jointly Fourier transformed signal is detected at the spatial frequency domain and inversely Fourier transformed again. Then, the final correlation peaks between them can be found in the correlation plane as an authentic signal. From good experimental results on multiple information hiding and optical extraction using Arabic numerials of "1", "2" and "3", a possibility of implementation of a new optodigital multiple information hiding and real-time extraction system is suggested.

  15. Methodology on high ratio multiple configuration systems in image sensor

    NASA Astrophysics Data System (ADS)

    Liu, Hua; Ding, Quanxin; Zhou, Liwei

    2014-12-01

    The method of a multiple configuration on high ratio systems in image sensor is an important subject. In such an experimental configuration, for aim to break through to large ratio multiple configuration systems bottlenecks, achieve the field of continuous transformation, effect system close to the theoretical limit and configuration dexterity, such as the purpose, method in the design of the integrated sensor system process, the core technology of such a system are thoroughly analyzed and the factors important to the compromise. Theory is studied based on the theory of Gaussian optical system error distribution and comprehensive balancing algorithm; Global optimization method, developed at a system design thought and the optimization model. Results solved the MTF matching problem, research and evaluations shows that the zoom ratio of more than one hundred results in system MTF and so on as qualitative criterion to achieve requirements.

  16. Design of a Hierarchical System Using PID Control with an Intelligent Sequence Controller and Its Application to Ethylene Plants in Unsteady State

    NASA Astrophysics Data System (ADS)

    Tani, Tetsuji; Takeuchi, Takeshi

    A hierarchical system is developed that consists of an intelligent sequence controller and a PID controller, where the intelligent sequence controller supervises the PID controller. In other words, the intelligent sequence controller plays the role of a well-experienced operator and mimics the operator's procedures. In an ethylene plant, the decoking operation of the cracking furnace makes the ethylene plant highly unstable. We apply this hierarchical system to the decoking process in an ethylene plant in order to demonstrate its effectiveness. As a result, the number of operational interventions in the decoking process is reduced by 95%, and the levels of the towers and the overhead temperatures of the towers can be satisfactorily stabilized during the decoking process.

  17. Using Multiple Unmanned Systems for a Site Security Task

    SciTech Connect

    Matthew O. Anderson; Curtis W. Nielsen; Mark D. McKay; Derek C. Wadsworth; Ryan C. Hruska; John A. Koudelka

    2009-04-01

    Unmanned systems are often used to augment the ability of humans to perform challenging tasks. While the value of individual unmanned vehicles have been proven for a variety of tasks, it is less understood how multiple unmanned systems should be used together to accomplish larger missions such as site security. The purpose of this paper is to discuss efforts by researchers at the Idaho National Laboratory (INL) to explore the utility and practicality of operating multiple unmanned systems for a site security mission. This paper reviews the technology developed for a multi-agent mission and summarizes the lessons-learned from a technology demonstration.

  18. Hierarchically nanostructured materials for sustainable environmental applications

    PubMed Central

    Ren, Zheng; Guo, Yanbing; Liu, Cai-Hong; Gao, Pu-Xian

    2013-01-01

    This review presents a comprehensive overview of the hierarchical nanostructured materials with either geometry or composition complexity in environmental applications. The hierarchical nanostructures offer advantages of high surface area, synergistic interactions, and multiple functionalities toward water remediation, biosensing, environmental gas sensing and monitoring as well as catalytic gas treatment. Recent advances in synthetic strategies for various hierarchical morphologies such as hollow spheres and urchin-shaped architectures have been reviewed. In addition to the chemical synthesis, the physical mechanisms associated with the materials design and device fabrication have been discussed for each specific application. The development and application of hierarchical complex perovskite oxide nanostructures have also been introduced in photocatalytic water remediation, gas sensing, and catalytic converter. Hierarchical nanostructures will open up many possibilities for materials design and device fabrication in environmental chemistry and technology. PMID:24790946

  19. Hierarchical random cellular neural networks for system-level brain-like signal processing.

    PubMed

    Kozma, Robert; Puljic, Marko

    2013-09-01

    Sensory information processing and cognition in brains are modeled using dynamic systems theory. The brain's dynamic state is described by a trajectory evolving in a high-dimensional state space. We introduce a hierarchy of random cellular automata as the mathematical tools to describe the spatio-temporal dynamics of the cortex. The corresponding brain model is called neuropercolation which has distinct advantages compared to traditional models using differential equations, especially in describing spatio-temporal discontinuities in the form of phase transitions. Phase transitions demarcate singularities in brain operations at critical conditions, which are viewed as hallmarks of higher cognition and awareness experience. The introduced Monte-Carlo simulations obtained by parallel computing point to the importance of computer implementations using very large-scale integration (VLSI) and analog platforms.

  20. MOOSES: Multiple Option Observation System for Experimental Studies.

    ERIC Educational Resources Information Center

    Tapp, Jon; Wehby, Joseph

    The Multiple Option Observation System for Experimental Studies (MOOSES) is a flexible data collection and analysis package for applied behavioral research that addresses the needs of researchers interested in live coding of observational data. MOOSES allows the researcher to design a coding system for a particular research question. General types…

  1. MULTIPLE PROJECTIONS SYSTEM (MPS) - USER'S MANUAL VERSION 1.0

    EPA Science Inventory

    The report is a user's manual for version 1.0 of the Multiple Projections Systems (MPS), a computer system that can perform "what if" scenario analysis and report the final results (i.e., Rate of Further Progress - ROP - inventories) to EPA (i.e., the Aerometric Information Retri...

  2. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  3. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  4. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  5. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  6. Hierarchical Gene Selection and Genetic Fuzzy System for Cancer Microarray Data Classification

    PubMed Central

    Nguyen, Thanh; Khosravi, Abbas; Creighton, Douglas; Nahavandi, Saeid

    2015-01-01

    This paper introduces a novel approach to gene selection based on a substantial modification of analytic hierarchy process (AHP). The modified AHP systematically integrates outcomes of individual filter methods to select the most informative genes for microarray classification. Five individual ranking methods including t-test, entropy, receiver operating characteristic (ROC) curve, Wilcoxon and signal to noise ratio are employed to rank genes. These ranked genes are then considered as inputs for the modified AHP. Additionally, a method that uses fuzzy standard additive model (FSAM) for cancer classification based on genes selected by AHP is also proposed in this paper. Traditional FSAM learning is a hybrid process comprising unsupervised structure learning and supervised parameter tuning. Genetic algorithm (GA) is incorporated in-between unsupervised and supervised training to optimize the number of fuzzy rules. The integration of GA enables FSAM to deal with the high-dimensional-low-sample nature of microarray data and thus enhance the efficiency of the classification. Experiments are carried out on numerous microarray datasets. Results demonstrate the performance dominance of the AHP-based gene selection against the single ranking methods. Furthermore, the combination of AHP-FSAM shows a great accuracy in microarray data classification compared to various competing classifiers. The proposed approach therefore is useful for medical practitioners and clinicians as a decision support system that can be implemented in the real medical practice. PMID:25823003

  7. System-wide assembly of pathways and modules hierarchically reveal metabolic mechanism of cerebral ischemia

    PubMed Central

    Zhu, Yan; Guo, Zhili; Zhang, Liangxiao; Zhang, Yingying; Chen, Yinying; Nan, Jingyi; Zhao, Buchang; Xiao, Hongbin; Wang, Zhong; Wang, Yongyan

    2015-01-01

    The relationship between cerebral ischemia and metabolic disorders is poorly understood, which is partly due to the lack of comparative fusing data for larger complete systems and to the complexity of metabolic cascade reactions. Based on the fusing maps of comprehensive serum metabolome, fatty acid and amino acid profiling, we identified 35 potential metabolic biomarkers for ischemic stroke. Our analyses revealed 8 significantly altered pathways by MetPA (Metabolomics Pathway Analysis, impact score >0.10) and 15 significantly rewired modules in a complex ischemic network using the Markov clustering (MCL) method; all of these pathways became more homologous as the number of overlapping nodes was increased. We then detected 24 extensive pathways based on the total modular nodes from the network analysis, 12 of which were new discovery pathways. We provided a new perspective from the viewpoint of abnormal metabolites for the overall study of ischemic stroke as well as a new method to simplify the network analysis by selecting the more closely connected edges and nodes to build a module map of stroke. PMID:26621314

  8. WASP-22 b: A TRANSITING 'HOT JUPITER' PLANET IN A HIERARCHICAL TRIPLE SYSTEM

    SciTech Connect

    Maxted, P. F. L.; Anderson, D. R.; Hellier, C.; Smalley, B.; Wilson, D. M.; Bentley, S. J.; Cegla, H.; Gillon, M.; Queloz, D.; Triaud, A. H. M. J.; Mayor, M.; Pepe, F.; West, R. G.; Collier Cameron, A.; Enoch, B.; Hebb, L.; Horne, K.; Parley, N.; Irwin, J.; Lister, T. A.

    2010-12-15

    We report the discovery of a transiting planet orbiting the star TYC 6446-326-1. The star, WASP-22, is a moderately bright (V = 12.0) solar-type star (T{sub eff} = 6000 {+-} 100 K, [Fe/H] = -0.05 {+-} 0.08). The light curve of the star obtained with the WASP-South instrument shows periodic transit-like features with a depth of about 1% and a duration of 0.14 days. The presence of a transit-like feature in the light curve is confirmed using z-band photometry obtained with Faulkes Telescope South. High-resolution spectroscopy obtained with the CORALIE and HARPS spectrographs confirms the presence of a planetary mass companion with an orbital period of 3.533 days in a near-circular orbit. From a combined analysis of the spectroscopic and photometric data assuming that the star is a typical main-sequence star we estimate that the planet has a mass M{sub p} = 0.56 {+-} 0.02M{sub Jup} and a radius R{sub p} = 1.12 {+-} 0.04R{sub Jup}. In addition, there is a linear trend of 40 m s{sup -1} yr{sup -1} in the radial velocities measured over 16 months, from which we infer the presence of a third body with a long-period orbit in this system. The companion may be a low mass M-dwarf, a white dwarf, or a second planet.

  9. HIP 3678: a hierarchical triple stellar system in the centre of the planetary nebula NGC 246

    NASA Astrophysics Data System (ADS)

    Adam, C.; Mugrauer, M.

    2014-11-01

    We report the detection of a new low-mass stellar companion to the white dwarf HIP 3678 A, the central star of the planetary nebula NGC 246. The newly found companion is located about 1 arcsec (at projected separation of about 500 au) north-east of HIP 3678 A, and shares a common proper motion with the white dwarf and its known comoving companion HIP 3678 B. The hypothesis that the newly detected companion is a non-moving background object can be rejected on a significance level of more than 8σ, by combining astrometric measurements from the literature with follow-up astrometry, obtained with Wide Field Planetary Camera 2/Hubble Space Telescope and NACO/Very Large Telescope. From our deep NACO imaging data, we can rule out additional stellar companions of the white dwarf with projected separations between 130 up to 5500 au. In the deepest high-contrast NACO observation, we achieve a detection limit in the Ks band of about 20 mag, which allows the detection of brown dwarf companions with masses down to 36 Mjup at an assumed age of the system of 260 Myr. To approximate the masses of the companions HIP 3678 B and C, we use the evolutionary Baraffe et al. models and obtain about 0.85 M⊙ for HIP 3678 B and about 0.1 M⊙ for HIP 3678 C. According to the derived absolute photometry, HIP 3678 B should be a early to mid-K dwarf (K2-K5), while HIP 3678 C should be a mid M dwarf with a spectral type in the range between M5 and M6.

  10. Multiple sex chromosome systems in howler monkeys (Platyrrhini, Alouatta)

    PubMed Central

    Steinberg, Eliana Ruth; Nieves, Mariela; Mudry, Marta Dolores

    2014-01-01

    Abstract In light of the multiple sex chromosome systems observed in howler monkeys (Alouatta Lacépède, 1799) a combined cladistic analysis using chromosomal and molecular characters was applied to discuss the possible origin of these systems. Mesoamerican and South American howlers were karyologically compared. FISH analysis using the chromosome painting probes for the #3 and #15 human chromosomes was applied to corroborate the homeology of the sexual systems. We found that the HSA3/15 syntenic association, present in the sex chromosome systems of South American Howlers, is not present in those of Mesoamerican ones. The autosomes involved in the translocation that formed the sexual systems in the Mesoamerican and South American species are different, thus suggesting an independent origin. Parsimony analysis resolved the phylogenetic relationships among howler species, demonstrating utility of the combined approach. A hypothesis for the origin of the multiple sex chromosome systems for the genus is proposed. PMID:24744833

  11. Large eccentricity, low mutual inclination: the three-dimensional architecture of a hierarchical system of giant planets

    SciTech Connect

    Dawson, Rebekah I.; Clubb, Kelsey I.; Johnson, John Asher; Murray-Clay, Ruth A.; Fabrycky, Daniel C.; Foreman-Mackey, Daniel; Buchhave, Lars A.; Cargile, Phillip A.; Fulton, Benjamin J.; Howard, Andrew W.; Hebb, Leslie; Huber, Daniel; Shporer, Avi; Valenti, Jeff A.

    2014-08-20

    We establish the three-dimensional architecture of the Kepler-419 (previously KOI-1474) system to be eccentric yet with a low mutual inclination. Kepler-419b is a warm Jupiter at semi-major axis a=0.370{sub −0.006}{sup +0.007} AU with a large eccentricity (e = 0.85{sub −0.07}{sup +0.08}) measured via the 'photoeccentric effect'. It exhibits transit timing variations (TTVs) induced by the non-transiting Kepler-419c, which we uniquely constrain to be a moderately eccentric (e = 0.184 ± 0.002), hierarchically separated (a = 1.68 ± 0.03 AU) giant planet (7.3 ± 0.4 M {sub Jup}). We combine 16 quarters of Kepler photometry, radial-velocity (RV) measurements from the HIgh Resolution Echelle Spectrometer on Keck, and improved stellar parameters that we derive from spectroscopy and asteroseismology. From the RVs, we measure the mass of the inner planet to be 2.5 ± 0.3 M {sub Jup} and confirm its photometrically measured eccentricity, refining the value to e = 0.83 ± 0.01. The RV acceleration is consistent with the properties of the outer planet derived from TTVs. We find that despite their sizable eccentricities, the planets are coplanar to within 9{sub −6}{sup +8} degrees, and therefore the inner planet's large eccentricity and close-in orbit are unlikely to be the result of Kozai migration. Moreover, even over many secular cycles, the inner planet's periapse is most likely never small enough for tidal circularization. Finally, we present and measure a transit time and impact parameter from four simultaneous ground-based light curves from 1 m class telescopes, demonstrating the feasibility of ground-based follow-up of Kepler giant planets exhibiting large TTVs.

  12. Dynamical systems with multiple long-delayed feedbacks: Multiscale analysis and spatiotemporal equivalence.

    PubMed

    Yanchuk, Serhiy; Giacomelli, Giovanni

    2015-10-01

    Dynamical systems with multiple, hierarchically long-delayed feedback are introduced and studied extending our previous work [Yanchuk and Giacomelli, Phys. Rev. Lett. 112, 174103 (2014)]. Focusing on the phenomenological model of a Stuart-Landau oscillator with two feedbacks, we show the multiscale properties of its dynamics and demonstrate them by means of a space-time representation. For sufficiently long delays, we derive a normal form describing the system close to the destabilization. The space and temporal variables, which are involved in the space-time representation, correspond to suitable time scales of the original system. The physical meaning of the results, together with the interpretation of the description at different scales, is presented and discussed. In particular, it is shown how this representation uncovers hidden multiscale patterns such as spirals or spatiotemporal chaos. The effect of the delay size and the features of the transition between small and large delays is also analyzed. Finally, we comment on the application of the method and on its extension to an arbitrary, but finite, number of delayed feedback terms. PMID:26565300

  13. Genetic Network Inference Using Hierarchical Structure

    PubMed Central

    Kimura, Shuhei; Tokuhisa, Masato; Okada-Hatakeyama, Mariko

    2016-01-01

    Many methods for inferring genetic networks have been proposed, but the regulations they infer often include false-positives. Several researchers have attempted to reduce these erroneous regulations by proposing the use of a priori knowledge about the properties of genetic networks such as their sparseness, scale-free structure, and so on. This study focuses on another piece of a priori knowledge, namely, that biochemical networks exhibit hierarchical structures. Based on this idea, we propose an inference approach that uses the hierarchical structure in a target genetic network. To obtain a reasonable hierarchical structure, the first step of the proposed approach is to infer multiple genetic networks from the observed gene expression data. We take this step using an existing method that combines a genetic network inference method with a bootstrap method. The next step is to extract a hierarchical structure from the inferred networks that is consistent with most of the networks. Third, we use the hierarchical structure obtained to assign confidence values to all candidate regulations. Numerical experiments are also performed to demonstrate the effectiveness of using the hierarchical structure in the genetic network inference. The improvement accomplished by the use of the hierarchical structure is small. However, the hierarchical structure could be used to improve the performances of many existing inference methods. PMID:26941653

  14. Multiple-User, Multitasking, Virtual-Memory Computer System

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R.; Roth, Don J.; Stang, David B.

    1993-01-01

    Computer system designed and programmed to serve multiple users in research laboratory. Provides for computer control and monitoring of laboratory instruments, acquisition and anlaysis of data from those instruments, and interaction with users via remote terminals. System provides fast access to shared central processing units and associated large (from megabytes to gigabytes) memories. Underlying concept of system also applicable to monitoring and control of industrial processes.

  15. Multiple-state quantum Otto engine, 1D box system

    SciTech Connect

    Latifah, E.; Purwanto, A.

    2014-03-24

    Quantum heat engines produce work using quantum matter as their working substance. We studied adiabatic and isochoric processes and defined the general force according to quantum system. The processes and general force are used to evaluate a quantum Otto engine based on multiple-state of one dimensional box system and calculate the efficiency. As a result, the efficiency depends on the ratio of initial and final width of system under adiabatic processes.

  16. Systemic Multiple Aneurysms Caused by Vascular Ehlers-Danlos Syndrome.

    PubMed

    Gui, Xinyu; Li, Fangda; Wu, Lingeer; Zheng, Yuehong

    2016-07-01

    Systemic multiple aneurysms are rare and usually associated with collagen tissue disease, such as Ehlers-Danlos syndrome (EDS) or Marfan syndrome. In the present case, we describe a 39-year-old male patient with systemic multiple aneurysms and acute intraperitoneal hemorrhage who was clinically diagnosed with vascular EDS. Coil embolization of the distal segment of the common hepatic artery was performed, which resolved the patient's symptoms. With this case presentation, we aim to increase the awareness of vascular EDS among clinicians and emphasize the extreme fragility of the arteries in patients with vascular EDS.

  17. System For Research On Multiple-Arm Robots

    NASA Technical Reports Server (NTRS)

    Backes, Paul G.; Hayati, Samad; Tso, Kam S.; Hayward, Vincent

    1991-01-01

    Kali system of computer programs and equipment provides environment for research on distributed programming and distributed control of coordinated-multiple-arm robots. Suitable for telerobotics research involving sensing and execution of low level tasks. Software and configuration of hardware designed flexible so system modified easily to test various concepts in control and programming of robots, including multiple-arm control, redundant-arm control, shared control, traded control, force control, force/position hybrid control, design and integration of sensors, teleoperation, task-space description and control, methods of adaptive control, control of flexible arms, and human factors.

  18. Systemic Multiple Aneurysms Caused by Vascular Ehlers-Danlos Syndrome.

    PubMed

    Gui, Xinyu; Li, Fangda; Wu, Lingeer; Zheng, Yuehong

    2016-07-01

    Systemic multiple aneurysms are rare and usually associated with collagen tissue disease, such as Ehlers-Danlos syndrome (EDS) or Marfan syndrome. In the present case, we describe a 39-year-old male patient with systemic multiple aneurysms and acute intraperitoneal hemorrhage who was clinically diagnosed with vascular EDS. Coil embolization of the distal segment of the common hepatic artery was performed, which resolved the patient's symptoms. With this case presentation, we aim to increase the awareness of vascular EDS among clinicians and emphasize the extreme fragility of the arteries in patients with vascular EDS. PMID:27206743

  19. M-dwarf rapid rotators and the detection of relatively young multiple M-star systems

    SciTech Connect

    Rappaport, S.; Joss, M.; Sanchis-Ojeda, R. E-mail: mattjoss@mit.edu; and others

    2014-06-20

    We have searched the Kepler light curves of ∼3900 M-star targets for evidence of periodicities that indicate, by means of the effects of starspots, rapid stellar rotation. Several analysis techniques, including Fourier transforms, inspection of folded light curves, 'sonograms', and phase tracking of individual modulation cycles, were applied in order to distinguish the periodicities due to rapid rotation from those due to stellar pulsations, eclipsing binaries, or transiting planets. We find 178 Kepler M-star targets with rotation periods, P {sub rot}, of <2 days, and 110 with P {sub rot} < 1 day. Some 30 of the 178 systems exhibit two or more independent short periods within the same Kepler photometric aperture, while several have 3 or more short periods. Adaptive optics imaging and modeling of the Kepler pixel response function for a subset of our sample support the conclusion that the targets with multiple periods are highly likely to be relatively young physical binary, triple, and even quadruple M star systems. We explore in detail the one object with four incommensurate periods all less than 1.2 days, and show that two of the periods arise from one of a close pair of stars, while the other two arise from the second star, which itself is probably a visual binary. If most of these M-star systems with multiple periods turn out to be bound M stars, this could prove a valuable way discovering young hierarchical M-star systems; the same approach may also be applicable to G and K stars. The ∼5% occurrence rate of rapid rotation among the ∼3900 M star targets is consistent with spin evolution models that include an initial contraction phase followed by magnetic braking, wherein a typical M star can spend several hundred Myr before spinning down to periods longer than 2 days.

  20. Possible planet formation in the young, low-mass, multiple stellar system GG Tau A.

    PubMed

    Dutrey, Anne; Di Folco, Emmanuel; Guilloteau, Stéphane; Boehler, Yann; Bary, Jeff; Beck, Tracy; Beust, Hervé; Chapillon, Edwige; Gueth, Fredéric; Huré, Jean-Marc; Pierens, Arnaud; Piétu, Vincent; Simon, Michal; Tang, Ya-Wen

    2014-10-30

    The formation of planets around binary stars may be more difficult than around single stars. In a close binary star (with a separation of less than a hundred astronomical units), theory predicts the presence of circumstellar disks around each star, and an outer circumbinary disk surrounding a gravitationally cleared inner cavity around the stars. Given that the inner disks are depleted by accretion onto the stars on timescales of a few thousand years, any replenishing material must be transferred from the outer reservoir to fuel planet formation (which occurs on timescales of about one million years). Gas flowing through disk cavities has been detected in single star systems. A circumbinary disk was discovered around the young low-mass binary system GG Tau A (ref. 7), which has recently been shown to be a hierarchical triple system. It has one large inner disk around the single star, GG Tau Aa, and shows small amounts of shocked hydrogen gas residing within the central cavity, but other than a single weak detection, the distribution of cold gas in this cavity or in any other binary or multiple star system has not hitherto been determined. Here we report imaging of gas fragments emitting radiation characteristic of carbon monoxide within the GG Tau A cavity. From the kinematics we conclude that the flow appears capable of sustaining the inner disk (around GG Tau Aa) beyond the accretion lifetime, leaving time for planet formation to occur there. These results show the complexity of planet formation around multiple stars and confirm the general picture predicted by numerical simulations.

  1. Possible planet formation in the young, low-mass, multiple stellar system GG Tau A

    NASA Astrophysics Data System (ADS)

    Dutrey, Anne; di Folco, Emmanuel; Guilloteau, Stéphane; Boehler, Yann; Bary, Jeff; Beck, Tracy; Beust, Hervé; Chapillon, Edwige; Gueth, Fredéric; Huré, Jean-Marc; Pierens, Arnaud; Piétu, Vincent; Simon, Michal; Tang, Ya-Wen

    2014-10-01

    The formation of planets around binary stars may be more difficult than around single stars. In a close binary star (with a separation of less than a hundred astronomical units), theory predicts the presence of circumstellar disks around each star, and an outer circumbinary disk surrounding a gravitationally cleared inner cavity around the stars. Given that the inner disks are depleted by accretion onto the stars on timescales of a few thousand years, any replenishing material must be transferred from the outer reservoir to fuel planet formation (which occurs on timescales of about one million years). Gas flowing through disk cavities has been detected in single star systems. A circumbinary disk was discovered around the young low-mass binary system GG Tau A (ref. 7), which has recently been shown to be a hierarchical triple system. It has one large inner disk around the single star, GG Tau Aa, and shows small amounts of shocked hydrogen gas residing within the central cavity, but other than a single weak detection, the distribution of cold gas in this cavity or in any other binary or multiple star system has not hitherto been determined. Here we report imaging of gas fragments emitting radiation characteristic of carbon monoxide within the GG Tau A cavity. From the kinematics we conclude that the flow appears capable of sustaining the inner disk (around GG Tau Aa) beyond the accretion lifetime, leaving time for planet formation to occur there. These results show the complexity of planet formation around multiple stars and confirm the general picture predicted by numerical simulations.

  2. Credit networks and systemic risk of Chinese local financing platforms: Too central or too big to fail?. -based on different credit correlations using hierarchical methods

    NASA Astrophysics Data System (ADS)

    He, Fang; Chen, Xi

    2016-11-01

    The accelerating accumulation and risk concentration of Chinese local financing platforms debts have attracted wide attention throughout the world. Due to the network of financial exposures among institutions, the failure of several platforms or regions of systemic importance will probably trigger systemic risk and destabilize the financial system. However, the complex network of credit relationships in Chinese local financing platforms at the state level remains unknown. To fill this gap, we presented the first complex networks and hierarchical cluster analysis of the credit market of Chinese local financing platforms using the "bottom up" method from firm-level data. Based on balance-sheet channel, we analyzed the topology and taxonomy by applying the analysis paradigm of subdominant ultra-metric space to an empirical data in 2013. It is remarked that we chose to extract the network of co-financed financing platforms in order to evaluate the effect of risk contagion from platforms to bank system. We used the new credit similarity measure by combining the factor of connectivity and size, to extract minimal spanning trees (MSTs) and hierarchical trees (HTs). We found that: (1) the degree distributions of credit correlation backbone structure of Chinese local financing platforms are fat tailed, and the structure is unstable with respect to targeted failures; (2) the backbone is highly hierarchical, and largely explained by the geographic region; (3) the credit correlation backbone structure based on connectivity and size is significantly heterogeneous; (4) key platforms and regions of systemic importance, and contagion path of systemic risk are obtained, which are contributed to preventing systemic risk and regional risk of Chinese local financing platforms and preserving financial stability under the framework of macro prudential supervision. Our approach of credit similarity measure provides a means of recognizing "systemically important" institutions and regions

  3. Hierarchical Spatio-Temporal Probabilistic Graphical Model with Multiple Feature Fusion for Binary Facial Attribute Classification in Real-World Face Videos.

    PubMed

    Demirkus, Meltem; Precup, Doina; Clark, James J; Arbel, Tal

    2016-06-01

    Recent literature shows that facial attributes, i.e., contextual facial information, can be beneficial for improving the performance of real-world applications, such as face verification, face recognition, and image search. Examples of face attributes include gender, skin color, facial hair, etc. How to robustly obtain these facial attributes (traits) is still an open problem, especially in the presence of the challenges of real-world environments: non-uniform illumination conditions, arbitrary occlusions, motion blur and background clutter. What makes this problem even more difficult is the enormous variability presented by the same subject, due to arbitrary face scales, head poses, and facial expressions. In this paper, we focus on the problem of facial trait classification in real-world face videos. We have developed a fully automatic hierarchical and probabilistic framework that models the collective set of frame class distributions and feature spatial information over a video sequence. The experiments are conducted on a large real-world face video database that we have collected, labelled and made publicly available. The proposed method is flexible enough to be applied to any facial classification problem. Experiments on a large, real-world video database McGillFaces [1] of 18,000 video frames reveal that the proposed framework outperforms alternative approaches, by up to 16.96 and 10.13%, for the facial attributes of gender and facial hair, respectively.

  4. Hierarchical multilayer perceptron network-based fusion algorithms for detection/classification of mines using multiple acoustic images and magnetic data

    NASA Astrophysics Data System (ADS)

    Bello, Martin G.

    1996-05-01

    Hierarchical neural network approaches have been developed first for combining high and low frequency (HF and LF) Side Scan Sonar imagery, and then for the combination of both acoustic images and Magnetic data. The adopted acoustic data fusion approach consists in a image-screening/HF, LF blob matching stage, followed by an information fusion/classification stage. Three variants of the information fusion/classification algorithm were conceived and evaluated based on `aggregate-feature-combining', `neural-network-discriminant-combining', and individual classifier `decision-based-combining', respectively. The `discriminant- combining' case yielded the best classification performance, and when compared with individual HF, LF classifier performance resulted in at least an order of magnitude reduction in the density of false alarms. Next, results are obtained for combining both acoustic and magnetic data using the described high and low frequency side scan sonar discriminant combining fusion algorithm as a starting point. In the next step, acoustic image pair `tokens' are associated with magnetic `tokens', resulting in three classes of resulting `tokens': `associated' acoustic-pair and magnetic tokens, isolated acoustic-pair tokens, and isolated magnetic `tokens'. Neural network output discriminants are derived for each of the three types of tokens mentioned above, and are employed to make classification decisions. The resulting Detection/Classification Algorithm is evaluated based on a combined ground truth obtained from both acoustic and magnetic sources.

  5. Hierarchical Spatio-Temporal Probabilistic Graphical Model with Multiple Feature Fusion for Binary Facial Attribute Classification in Real-World Face Videos.

    PubMed

    Demirkus, Meltem; Precup, Doina; Clark, James J; Arbel, Tal

    2016-06-01

    Recent literature shows that facial attributes, i.e., contextual facial information, can be beneficial for improving the performance of real-world applications, such as face verification, face recognition, and image search. Examples of face attributes include gender, skin color, facial hair, etc. How to robustly obtain these facial attributes (traits) is still an open problem, especially in the presence of the challenges of real-world environments: non-uniform illumination conditions, arbitrary occlusions, motion blur and background clutter. What makes this problem even more difficult is the enormous variability presented by the same subject, due to arbitrary face scales, head poses, and facial expressions. In this paper, we focus on the problem of facial trait classification in real-world face videos. We have developed a fully automatic hierarchical and probabilistic framework that models the collective set of frame class distributions and feature spatial information over a video sequence. The experiments are conducted on a large real-world face video database that we have collected, labelled and made publicly available. The proposed method is flexible enough to be applied to any facial classification problem. Experiments on a large, real-world video database McGillFaces [1] of 18,000 video frames reveal that the proposed framework outperforms alternative approaches, by up to 16.96 and 10.13%, for the facial attributes of gender and facial hair, respectively. PMID:26415152

  6. A Hierarchical Multiple-Level Approach to the Assessment of Interpersonal Relatedness and Self-Definition: Implications for Research, Clinical Practice, and DSM Planning.

    PubMed

    Luyten, Patrick; Blatt, Sidney J

    2016-01-01

    Extant research suggests there is considerable overlap between so-called 2-polarities models of personality development; that is, models that propose that personality development evolves through a dialectic synergistic interaction between 2 key developmental tasks across the life span-the development of self-definition on the one hand and of relatedness on the other. These models have attracted considerable research attention and play a central role in DSM planning. This article provides a researcher- and clinician-friendly guide to the assessment of these personality theories. We argue that current theoretical models focus on issues of relatedness and self-definition at different hierarchically organized levels of analysis; that is (a) at the level of broad personality features, (b) at the motivational level (i.e., the motivational processes underlying the development of these dimensions), and (c) at the level of underlying internal working models or cognitive affective schemas, and the specific interpersonal features and problems in which they are expressed. Implications for further research and DSM planning are outlined.

  7. Detection and location of multiple events by MARS. Final report. [Multiple Arrival Recognition System

    SciTech Connect

    Wang, J.; Masso, J.F.; Archambeau, C.B.; Savino, J.M.

    1980-09-01

    Seismic data from two explosions was processed using the Systems Science and Software MARS (Multiple Arrival Recognition System) seismic event detector in an effort to determine their relative spatial and temporal separation on the basis of seismic data alone. The explosions were less than 1.0 kilometer apart and were separated by less than 0.5 sec in origin times. The seismic data consisted of nine local accelerograms (r < 1.0 km) and four regional (240 through 400 km) seismograms. The MARS processing clearly indicates the presence of multiple explosions, but the restricted frequency range of the data inhibits accurate time picks and hence limits the precision of the event location.

  8. COMPLEX ADAPTIVE HIERARCHICAL SYSTEMS

    EPA Science Inventory

    One of the most powerful images of our time, an image that has changed the way we think of ourselves and the way we think about our relationship to our environment, is the image of Earth viewed from the surface of the moon. As we view "spaceship Earth" we sense that the complexit...

  9. MIMD (multiple instruction multiple data) multiprocessor system for real-time image processing

    NASA Astrophysics Data System (ADS)

    Pirsch, Peter; Jeschke, Hartwig

    1991-06-01

    Anovel MIMD (Multiple Instruction Multiple Data) based architecture consisting of multiple processing elements (PE) has been developed. This architecture is adapted to real-time processing of sequences of different tasks for local image segments. Each PE contains an arithmetic processing unit (APU), adapted to parallel processing of low level operations, and a high level and control processor (HLCP) for medium and high level operations and control of the PE. This HLCP can be a standard signal processor or a RISC processor. Because of the local control of each PE by the HLCP and a SIMD structure of the APU, the overall system architecture is characterized as MIMD based with a local SIMD structure for low level processing. Due to an overlapped computation and communication the multiprocessor system achieves a linear speedup compared to a single processing element. Main parts of the PE have been realized as two ASICs in a 1.5 jim CMOS-Process. With a system clock rate of 25MHz, each PE provides a peak performance of 400 Mega operations per second (MOPS).

  10. On the relationship between cyclic and hierarchical three-species predator-prey systems and the two-species Lotka-Volterra model

    NASA Astrophysics Data System (ADS)

    He, Q.; Täuber, U. C.; Zia, R. K. P.

    2012-04-01

    Stochastic spatial predator-prey competition models represent paradigmatic systems to understand the emergence of biodiversity and the stability of ecosystems. We aim to clarify the relationship and connections between interacting three-species models and the classic two-species Lotka-Volterra (LV) model that entails predator-prey coexistence with long-lived population oscillations. To this end, we utilize mean-field theory and Monte Carlo simulations on two-dimensional square lattices to explore the temporal evolution characteristics of two different interacting three-species predator-prey systems, namely: (1) a cyclic rock-paper-scissors (RPS) model with conserved total particle number but strongly asymmetric reaction rates that lets the system evolve towards one "corner" of configuration space; (2) a hierarchical "food chain" where an additional intermediate species is inserted between the predator and prey in the LV model. For the asymmetric cyclic model variant (1), we demonstrate that the evolutionary properties of both minority species in the (quasi-)steady state of this stochastic spatial three-species "corner" RPS model are well approximated by the two-species LV system, with its emerging characteristic features of localized population clustering, persistent oscillatory dynamics, correlated spatio-temporal patterns, and fitness enhancement through quenched spatial disorder in the predation rates. In contrast, we could not identify any regime where the hierarchical three-species model (2) would reduce to the two-species LV system. In the presence of pair exchange processes, the system remains essentially well-mixed, and we generally find the Monte Carlo simulation results for the spatially extended hierarchical model (2) to be consistent with the predictions from the corresponding mean-field rate equations. If spreading occurs only through nearest-neighbor hopping, small population clusters emerge; yet the requirement of an intermediate species cluster

  11. SENTINEL: A Multiple Engine Information Retrieval and Visualization System.

    ERIC Educational Resources Information Center

    Fox, Kevin L.; Frieder, Ophir; Knepper, Margaret M.; Snowberg, Eric J.

    1999-01-01

    Describes SENTINEL, a prototype information-retrieval system that is a fusion of multiple information-retrieval technologies, integrating n-grams, a vector space model, and a neural network training rule. Discusses three-dimensional visualization capability, precision and recall, mathematical representation of a document, query building, and…

  12. A multiple objective optimization approach to aircraft control systems design

    NASA Technical Reports Server (NTRS)

    Tabak, D.; Schy, A. A.; Johnson, K. G.; Giesy, D. P.

    1979-01-01

    The design of an aircraft lateral control system, subject to several performance criteria and constraints, is considered. While in the previous studies of the same model a single criterion optimization, with other performance requirements expressed as constraints, has been pursued, the current approach involves a multiple criteria optimization. In particular, a Pareto optimal solution is sought.

  13. A Summarization System for Chinese News from Multiple Sources.

    ERIC Educational Resources Information Center

    Chen, Hsin-Hsi; Kuo, June-Jei; Huang, Sheng-Jie; Lin, Chuan-Jie; Wung, Hung-Chia

    2003-01-01

    Proposes a summarization system for multiple documents that employs named entities and other signatures to cluster news from different sources, as well as punctuation marks, linking elements, and topic chains to identify the meaningful units (MUs). Using nouns and verbs to identify similar MUs, focusing and browsing models are applied to represent…

  14. Magnetochirality in hierarchical magnetoplasmonic clusters

    NASA Astrophysics Data System (ADS)

    Yannopapas, Vassilios

    2015-09-01

    We show theoretically that finite hierarchical assemblies of clusters consisting magnetic (magnetite) and plasmonic (gold) nanoparticles show dramatically increased values of the magnetochiral dichroism compared to those measured in conventional materials exhibiting this phenomenon (liquid molecular systems, anisotropic crystals and chiral ferromagnets). These values are attributed to the strong interaction of the magnetite nanoparticles within the clusters as well as by the excitation of surface-plasmons in the gold nanoparticles. Along with the magnetochiral dichroism, in the studied hierarchical magnetoplasmonic designs, magneto-optical phenomena such as magnetic dichroism and Faraday rotation are also enhanced relative to the case of purely magnetic nanostructures.

  15. (3749) BALAM: A VERY YOUNG MULTIPLE ASTEROID SYSTEM

    SciTech Connect

    Vokrouhlicky, David

    2009-11-20

    Binaries and multiple systems among small bodies in the solar system have received wide attention over the past decade. This is because their observations provide a wealth of data otherwise inaccessible for single objects. We use numerical integration to prove that the multiple asteroid system (3749) Balam is very young, in contrast to its previously assumed age of 0.5-1 Gyr related to the formation of the Flora family. This work is enabled by a fortuitous discovery of a paired component to (3749) Balam. We first show that the proximity of the (3749) Balam and 2009 BR60 orbits is not a statistical fluke of otherwise quasi-uniform distribution. Numerical integrations then strengthen the case and allow us to prove that 2009 BR60 separated from the Balam system less than a million years ago. This is the first time the age of a binary asteroid can be estimated with such accuracy.

  16. Building a cognitive map by assembling multiple path integration systems.

    PubMed

    Wang, Ranxiao Frances

    2016-06-01

    Path integration and cognitive mapping are two of the most important mechanisms for navigation. Path integration is a primitive navigation system which computes a homing vector based on an animal's self-motion estimation, while cognitive map is an advanced spatial representation containing richer spatial information about the environment that is persistent and can be used to guide flexible navigation to multiple locations. Most theories of navigation conceptualize them as two distinctive, independent mechanisms, although the path integration system may provide useful information for the integration of cognitive maps. This paper demonstrates a fundamentally different scenario, where a cognitive map is constructed in three simple steps by assembling multiple path integrators and extending their basic features. The fact that a collection of path integration systems can be turned into a cognitive map suggests the possibility that cognitive maps may have evolved directly from the path integration system.

  17. NEXT Propellant Management System Integration With Multiple Ion Thrusters

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Soulas, George C.; Herman, Daniel A.

    2011-01-01

    As a critical part of the NEXT test validation process, a multiple-string integration test was performed on the NEXT propellant management system and ion thrusters. The objectives of this test were to verify that the PMS is capable of providing stable flow control to multiple thrusters operating over the NEXT system throttling range and to demonstrate to potential users that the NEXT PMS is ready for transition to flight. A test plan was developed for the sub-system integration test for verification of PMS and thruster system performance and functionality requirements. Propellant management system calibrations were checked during the single and multi-thruster testing. The low pressure assembly total flow rates to the thruster(s) were within 1.4 percent of the calibrated support equipment flow rates. The inlet pressures to the main, cathode, and neutralizer ports of Thruster PM1R were measured as the PMS operated in 1-thruster, 2-thruster, and 3-thruster configurations. It was found that the inlet pressures to Thruster PM1R for 2-thruster and 3-thruster operation as well as single thruster operation with the PMS compare very favorably indicating that flow rates to Thruster PM1R were similar in all cases. Characterizations of discharge losses, accelerator grid current, and neutralizer performance were performed as more operating thrusters were added to the PMS. There were no variations in these parameters as thrusters were throttled and single and multiple thruster operations were conducted. The propellant management system power consumption was at a fixed voltage to the DCIU and a fixed thermal throttle temperature of 75 C. The total power consumed by the PMS was 10.0, 17.9, and 25.2 W, respectively, for single, 2-thruster, and 3-thruster operation with the PMS. These sub-system integration tests of the PMS, the DCIU Simulator, and multiple thrusters addressed, in part, the NEXT PMS and propulsion system performance and functionality requirements.

  18. Multiple-etalon systems for the Advanced Technology Solar Telescope

    NASA Technical Reports Server (NTRS)

    Gary, G. Allen; Balasubramaniam, K. S.; Sigwarth, Michael

    2003-01-01

    Multiple etalon systems are discussed that meet the science requirements for a narrow-passband imaging system for the 4-meter National Solar Observatory (NSO)/Advance Technology Solar Telescope (ATST). A multiple etalon system can provide an imaging interferometer that works in four distinct modes: as a spectro-polarimeter, a filter-vector magnetograph, an intermediate-band imager, and broadband high-resolution imager. Specific dual and triple etalon configurations are described that provide a spectrographic passband of 2.0-3.5 micron and reduce parasitic light levels to 10(exp -4) as required for precise polarization measurement, e.g., Zeeman measurements of magnetic sensitive lines. A TESOS-like (Telecentric Etalon SOlar Spectrometer) triple etalon system provides a spectral purity of 10(exp -5). The triple designs have the advantage of reducing the finesse requirement on each etalon; allow the use of more stable blocking filters, and have very high spectral purity. A dual-etalon double-pass (Cavallini-like) system can provide a competing configuration. Such a dual-etalon design can provide high contrast. The selection of the final focal plane instrument will depend on a trade-off between an ideal instrument and practical reality. The trade study will include the number of etalons, their aperture sizes, complexities of the optical train, number of blocking filters, configuration of the electronic control system, computer interfaces, temperature controllers, etalon controllers, and their associated feedback electronics. The heritage of single and multiple etalon systems comes from their use in several observatories, including the Marshall Space Flight Center (MSFC) Solar Observatory, Sacramento Peak Observatory (NSO), and Kiepenheuer-Institut fur Sonnenphysik (KIS, Germany), Mees Solar Observatory (University of Hawaii), and Arcetri Astrophysical Observatory (Italy). The design of the ATST multiple etalon system will benefit from the experience gained at these

  19. System Configured For Applying Multiple Modifying Agents To A Substrate.

    DOEpatents

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2005-11-08

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  20. System configured for applying multiple modifying agents to a substrate

    DOEpatents

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2003-11-25

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  1. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System.

    PubMed

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-01-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well. PMID:27146453

  2. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System

    NASA Astrophysics Data System (ADS)

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-05-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well.

  3. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System

    PubMed Central

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-01-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well. PMID:27146453

  4. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System.

    PubMed

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-01-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well.

  5. Multiple Etalon Systems for the Advanced Technology Solar Telescope

    NASA Technical Reports Server (NTRS)

    Gary, G. Allen; Balasubramaniam, K. S.; Sigwarth, Michael; Six, N. Frank (Technical Monitor)

    2002-01-01

    Multiple etalons systems are discussed that meet the 4-meter NSO/Advance Technology Solar Telescope (http://www.nso.edu/ATST/index.html) instrument and science requirements for a narrow bandpass imaging system. A multiple etalon system can provide an imaging interferometer working in four distinct modes: as a spectro-polarimeter, a filter-vector magnetograph, and a wide-band and broad-band high-resolution imager. Specific dual and triple etalon configurations will be described that provides spectrographic passband of 2.0-3.5nm and reduces parasitic light levels to 1/10000 as required by precise polarization measurement, e.g., Zeeman measurements of magnetic sensitive lines. A TESOS-like triple etalon system provides for spectral purity of 100 thousandths. The triple designs have the advantage of reducing the finesse requirement on each etalon, allowing much more stable blocking filters, and can have very high spectral purity. A dual-etalon double-pass Cavallini-like configuration can provide a competing configuration. This design can provide high contrast with only a double etalon. The selection of the final focal plan instrument will depend on a trade-off of the ideal instrument versus reality, the number of etalons, the aperture of etalons, the number of blocking filters the electronic control system and computer interfaces, the temperature control and controllers for the etalons and the electronics. The use of existing experience should provide significant cost savings. The heritage of use of etalons and multiple etalon systems in solar physics come from a number of observatories, which includes MSFC Solar Observatory (NASA), Sac Peak Observatory (NSO), and Kiepenheuer Institute for Solar Physics (Germany), Mees Solar Observatory (University of Hawaii), and Arcetri Astrophysical Observatory (Italy). The design of the ATST multiple etalon system will reply on the existing experience from these observatories.

  6. Multiple kink solutions and multiple singular kink solutions for two systems of coupled Burgers-type equations

    NASA Astrophysics Data System (ADS)

    Wazwaz, Abdul-Majid

    2009-07-01

    Two systems of integrable coupled Burgers-type equations are investigated. The Cole-Hopf transformation combined with the Hirota's bilinear sense are employed for a reliable treatment of these two systems. Multiple kink solutions and multiple singular kink solutions are formally derived for each system.

  7. Galerkin projection methods for solving multiple related linear systems

    SciTech Connect

    Chan, T.F.; Ng, M.; Wan, W.L.

    1996-12-31

    We consider using Galerkin projection methods for solving multiple related linear systems A{sup (i)}x{sup (i)} = b{sup (i)} for 1 {le} i {le} s, where A{sup (i)} and b{sup (i)} are different in general. We start with the special case where A{sup (i)} = A and A is symmetric positive definite. The method generates a Krylov subspace from a set of direction vectors obtained by solving one of the systems, called the seed system, by the CG method and then projects the residuals of other systems orthogonally onto the generated Krylov subspace to get the approximate solutions. The whole process is repeated with another unsolved system as a seed until all the systems are solved. We observe in practice a super-convergence behaviour of the CG process of the seed system when compared with the usual CG process. We also observe that only a small number of restarts is required to solve all the systems if the right-hand sides are close to each other. These two features together make the method particularly effective. In this talk, we give theoretical proof to justify these observations. Furthermore, we combine the advantages of this method and the block CG method and propose a block extension of this single seed method. The above procedure can actually be modified for solving multiple linear systems A{sup (i)}x{sup (i)} = b{sup (i)}, where A{sup (i)} are now different. We can also extend the previous analytical results to this more general case. Applications of this method to multiple related linear systems arising from image restoration and recursive least squares computations are considered as examples.

  8. Distributed magnetic field positioning system using code division multiple access

    NASA Technical Reports Server (NTRS)

    Prigge, Eric A. (Inventor)

    2003-01-01

    An apparatus and methods for a magnetic field positioning system use a fundamentally different, and advantageous, signal structure and multiple access method, known as Code Division Multiple Access (CDMA). This signal architecture, when combined with processing methods, leads to advantages over the existing technologies, especially when applied to a system with a large number of magnetic field generators (beacons). Beacons at known positions generate coded magnetic fields, and a magnetic sensor measures a sum field and decomposes it into component fields to determine the sensor position and orientation. The apparatus and methods can have a large `building-sized` coverage area. The system allows for numerous beacons to be distributed throughout an area at a number of different locations. A method to estimate position and attitude, with no prior knowledge, uses dipole fields produced by these beacons in different locations.

  9. Alternative multiple-access techniques for mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Smith, Patrick O.; Geraniotis, Evaggelos

    1989-01-01

    The use of Code Division Multiple Access (CDMA) to satisfy the diverse requirements of a generic (land, maritime, aeronautical) mobile satellite system (MSS) network design is discussed. Comparisons between CDMA and Frequency Division Multiple Access (FDMA) show that a CDMA network design can support significantly more voice channel allocations than FDMA when relatively simple CDMA correlation receivers are employed, provided that there is sufficient space segment equivalent isotropically radiated power (EIRP). The use of more advanced CDMA receivers can improve the spectral and power efficiency. Although the use of CDMA may not gain immediate and widespread support in the international MSS community, provision for the use of CDMA for a domestic system in the U.S., and possibly for a regional system throughout North America, is likely.

  10. Multiple-input, multiple-output system identification for characterization of limb stiffness dynamics.

    PubMed

    Perreault, E J; Kirsch, R F; Acosta, A M

    1999-05-01

    This study presents time-domain and frequency-domain, multiple-input, multiple-output (MIMO) linear system identification techniques that can be used to estimate the dynamic endpoint stiffness of a multijoint limb. The stiffness of a joint or limb arises from a number of physiological mechanisms and is thought to play a fundamental role in the control of posture and movement. Estimates of endpoint stiffness can therefore be used to characterize its modulation during physiological tasks and may provide insight into how the nervous system normally controls motor behavior. Previous MIMO stiffness estimates have focused upon the static stiffness components only or assumed simple parametric models with elastic, viscous, and inertial components. The method presented here captures the full stiffness dynamics during a relatively short experimental trial while assuming only that the system is linear for small perturbations. Simulation studies were performed to investigate the performance of this approach under typical experimental conditions. It was found that a linear MIMO description of endpoint stiffness dynamics was sufficient to describe the displacement responses to small stochastic force perturbations. Distortion of these linear estimates by nonlinear centripetal and Coriolis forces was virtually undetectable for these perturbations. The system identification techniques were also found to be robust in the presence of significant output measurement noise and input coupling. These results indicate that the approach described here will allow the estimation of endpoint stiffness dynamics in an experimentally efficient manner with minimal assumptions about the specific form of these properties. PMID:10365425

  11. Studies on the formation of hierarchical zeolite T aggregates with well-defined morphology in different template systems

    NASA Astrophysics Data System (ADS)

    Yin, Xiaoyan; Chu, Naibo; Lu, Xuewei; Li, Zhongfang; Guo, Hong

    2016-01-01

    In this paper, the disk-like and pumpkin-like hierarchical zeolite T aggregates consisted of primary nano-grains have been hydrothermally synthesized with and without the aid of the second template. The first template is used with tetramethylammonium hydroxide (TMAOH) and the second template is used with triethanolamine (TEA) or polyving akohol (PVA). A combination of characterization techniques, including XRD, SEM, TEM and N2 adsorption-desorption to examine the crystal crystallinity, morphology and surface properties of hierarchical zeolite T aggregates. In the single-template preparation process, the two-step varying-temperature treatment has been used to improve the meso-porosity of zeolite T aggregates. In the double-template preparation process, the amounts of PVA or TEA on the crystallinity, morphology and meso-porosity of zeolite T aggregates have been studied. It has been proved that the interstitial voids between the primary grains of aggregates are the origin of additional mesopores of samples. The micro- and meso-porosities of samples prepared with and without the second template have been contrasted in detail at last. In particular, the sample synthesized with the addition of PVA presents a hierarchical pore structure with the highest Sext value of 122 m2/g and Vmeso value of 0.255 cm3/g.

  12. Hierarchical Cluster Analysis of Three-Dimensional Reconstructions of Unbiased Sampled Microglia Shows not Continuous Morphological Changes from Stage 1 to 2 after Multiple Dengue Infections in Callithrix penicillata

    PubMed Central

    Diniz, Daniel G.; Silva, Geane O.; Naves, Thaís B.; Fernandes, Taiany N.; Araújo, Sanderson C.; Diniz, José A. P.; de Farias, Luis H. S.; Sosthenes, Marcia C. K.; Diniz, Cristovam G.; Anthony, Daniel C.; da Costa Vasconcelos, Pedro F.; Picanço Diniz, Cristovam W.

    2016-01-01

    It is known that microglial morphology and function are related, but few studies have explored the subtleties of microglial morphological changes in response to specific pathogens. In the present report we quantitated microglia morphological changes in a monkey model of dengue disease with virus CNS invasion. To mimic multiple infections that usually occur in endemic areas, where higher dengue infection incidence and abundant mosquito vectors carrying different serotypes coexist, subjects received once a week subcutaneous injections of DENV3 (genotype III)-infected culture supernatant followed 24 h later by an injection of anti-DENV2 antibody. Control animals received either weekly anti-DENV2 antibodies, or no injections. Brain sections were immunolabeled for DENV3 antigens and IBA-1. Random and systematic microglial samples were taken from the polymorphic layer of dentate gyrus for 3-D reconstructions, where we found intense immunostaining for TNFα and DENV3 virus antigens. We submitted all bi- or multimodal morphological parameters of microglia to hierarchical cluster analysis and found two major morphological phenotypes designated types I and II. Compared to type I (stage 1), type II microglia were more complex; displaying higher number of nodes, processes and trees and larger surface area and volumes (stage 2). Type II microglia were found only in infected monkeys, whereas type I microglia was found in both control and infected subjects. Hierarchical cluster analysis of morphological parameters of 3-D reconstructions of random and systematic selected samples in control and ADE dengue infected monkeys suggests that microglia morphological changes from stage 1 to stage 2 may not be continuous. PMID:27047345

  13. Hierarchical Cluster Analysis of Three-Dimensional Reconstructions of Unbiased Sampled Microglia Shows not Continuous Morphological Changes from Stage 1 to 2 after Multiple Dengue Infections in Callithrix penicillata.

    PubMed

    Diniz, Daniel G; Silva, Geane O; Naves, Thaís B; Fernandes, Taiany N; Araújo, Sanderson C; Diniz, José A P; de Farias, Luis H S; Sosthenes, Marcia C K; Diniz, Cristovam G; Anthony, Daniel C; da Costa Vasconcelos, Pedro F; Picanço Diniz, Cristovam W

    2016-01-01

    It is known that microglial morphology and function are related, but few studies have explored the subtleties of microglial morphological changes in response to specific pathogens. In the present report we quantitated microglia morphological changes in a monkey model of dengue disease with virus CNS invasion. To mimic multiple infections that usually occur in endemic areas, where higher dengue infection incidence and abundant mosquito vectors carrying different serotypes coexist, subjects received once a week subcutaneous injections of DENV3 (genotype III)-infected culture supernatant followed 24 h later by an injection of anti-DENV2 antibody. Control animals received either weekly anti-DENV2 antibodies, or no injections. Brain sections were immunolabeled for DENV3 antigens and IBA-1. Random and systematic microglial samples were taken from the polymorphic layer of dentate gyrus for 3-D reconstructions, where we found intense immunostaining for TNFα and DENV3 virus antigens. We submitted all bi- or multimodal morphological parameters of microglia to hierarchical cluster analysis and found two major morphological phenotypes designated types I and II. Compared to type I (stage 1), type II microglia were more complex; displaying higher number of nodes, processes and trees and larger surface area and volumes (stage 2). Type II microglia were found only in infected monkeys, whereas type I microglia was found in both control and infected subjects. Hierarchical cluster analysis of morphological parameters of 3-D reconstructions of random and systematic selected samples in control and ADE dengue infected monkeys suggests that microglia morphological changes from stage 1 to stage 2 may not be continuous. PMID:27047345

  14. DEVELOPMENT OF A WIRELINE CPT SYSTEM FOR MULTIPLE TOOL USAGE

    SciTech Connect

    Stephen P. Farrington; Martin L. Gildea; J. Christopher Bianchi

    1999-08-01

    The first phase of development of a wireline cone penetrometer system for multiple tool usage was completed under DOE award number DE-AR26-98FT40366. Cone penetrometer technology (CPT) has received widespread interest and is becoming more commonplace as a tool for environmental site characterization activities at several Department of Energy (DOE) facilities. Although CPT already offers many benefits for site characterization, the wireline system can improve CPT technology by offering greater utility and increased cost savings. Currently the use of multiple CPT tools during a site characterization (i.e. piezometric cone, chemical sensors, core sampler, grouting tool) must be accomplished by withdrawing the entire penetrometer rod string to change tools. This results in multiple penetrations being required to collect the data and samples that may be required during characterization of a site, and to subsequently seal the resulting holes with grout. The wireline CPT system allows multiple CPT tools to be interchanged during a single penetration, without withdrawing the CPT rod string from the ground. The goal of the project is to develop and demonstrate a system by which various tools can be placed at the tip of the rod string depending on the type of information or sample desired. Under the base contract, an interchangeable piezocone and grouting tool was designed, fabricated, and evaluated. The results of the evaluation indicate that success criteria for the base contract were achieved. In addition, the wireline piezocone tool was validated against ASTM standard cones, the depth capability of the system was found to compare favorably with that of conventional CPT, and the reliability and survivability of the system were demonstrated.

  15. Multiple-Agent Air/Ground Autonomous Exploration Systems

    NASA Technical Reports Server (NTRS)

    Fink, Wolfgang; Chao, Tien-Hsin; Tarbell, Mark; Dohm, James M.

    2007-01-01

    Autonomous systems of multiple-agent air/ground robotic units for exploration of the surfaces of remote planets are undergoing development. Modified versions of these systems could be used on Earth to perform tasks in environments dangerous or inaccessible to humans: examples of tasks could include scientific exploration of remote regions of Antarctica, removal of land mines, cleanup of hazardous chemicals, and military reconnaissance. A basic system according to this concept (see figure) would include a unit, suspended by a balloon or a blimp, that would be in radio communication with multiple robotic ground vehicles (rovers) equipped with video cameras and possibly other sensors for scientific exploration. The airborne unit would be free-floating, controlled by thrusters, or tethered either to one of the rovers or to a stationary object in or on the ground. Each rover would contain a semi-autonomous control system for maneuvering and would function under the supervision of a control system in the airborne unit. The rover maneuvering control system would utilize imagery from the onboard camera to navigate around obstacles. Avoidance of obstacles would also be aided by readout from an onboard (e.g., ultrasonic) sensor. Together, the rover and airborne control systems would constitute an overarching closed-loop control system to coordinate scientific exploration by the rovers.

  16. Expanding the spectrum of neuronal pathology in multiple system atrophy

    PubMed Central

    Cykowski, Matthew D.; Coon, Elizabeth A.; Powell, Suzanne Z.; Jenkins, Sarah M.; Benarroch, Eduardo E.; Low, Phillip A.; Schmeichel, Ann M.

    2015-01-01

    Multiple system atrophy is a sporadic alpha-synucleinopathy that typically affects patients in their sixth decade of life and beyond. The defining clinical features of the disease include progressive autonomic failure, parkinsonism, and cerebellar ataxia leading to significant disability. Pathologically, multiple system atrophy is characterized by glial cytoplasmic inclusions containing filamentous alpha-synuclein. Neuronal inclusions also have been reported but remain less well defined. This study aimed to further define the spectrum of neuronal pathology in 35 patients with multiple system atrophy (20 male, 15 female; mean age at death 64.7 years; median disease duration 6.5 years, range 2.2 to 15.6 years). The morphologic type, topography, and frequencies of neuronal inclusions, including globular cytoplasmic (Lewy body-like) neuronal inclusions, were determined across a wide spectrum of brain regions. A correlation matrix of pathologic severity also was calculated between distinct anatomic regions of involvement (striatum, substantia nigra, olivary and pontine nuclei, hippocampus, forebrain and thalamus, anterior cingulate and neocortex, and white matter of cerebrum, cerebellum, and corpus callosum). The major finding was the identification of widespread neuronal inclusions in the majority of patients, not only in typical disease-associated regions (striatum, substantia nigra), but also within anterior cingulate cortex, amygdala, entorhinal cortex, basal forebrain and hypothalamus. Neuronal inclusion pathology appeared to follow a hierarchy of region-specific susceptibility, independent of the clinical phenotype, and the severity of pathology was duration-dependent. Neuronal inclusions also were identified in regions not previously implicated in the disease, such as within cerebellar roof nuclei. Lewy body-like inclusions in multiple system atrophy followed the stepwise anatomic progression of Lewy body-spectrum disease inclusion pathology in 25.7% of patients

  17. Mean-field limit of systems with multiplicative noise.

    PubMed

    Muñoz, Miguel A; Colaiori, Francesca; Castellano, Claudio

    2005-11-01

    A detailed study of the mean-field solution of Langevin equations with multiplicative noise is presented. Three different regimes depending on noise intensity (weak, intermediate, and strong noise) are identified by performing a self-consistent calculation on a fully connected lattice. The most interesting, strong-noise, regime is shown to be intrinsically unstable with respect to the inclusion of fluctuations, as a Ginzburg criterion shows. On the other hand, the self-consistent approach is shown to be valid only in the thermodynamic limit, while for finite systems the critical behavior is found to be different. In this last case, the self-consistent field itself is broadly distributed rather than taking a well defined mean value; its fluctuations, described by an effective zero-dimensional multiplicative noise equation, govern the critical properties. These findings are obtained analytically for a fully connected graph, and verified numerically both on fully connected graphs and on random regular networks. The results presented here shed some doubt on what is the validity and meaning of a standard mean-field approach in systems with multiplicative noise in finite dimensions, where each site does not see an infinite number of neighbors, but a finite one. The implications of all this on the existence of a finite upper critical dimension for multiplicative noise and Kardar-Parisi-Zhang problems are briefly discussed.

  18. Application of a hierarchical structure stochastic learning automation

    NASA Technical Reports Server (NTRS)

    Neville, R. G.; Chrystall, M. S.; Mars, P.

    1979-01-01

    A hierarchical structure automaton was developed using a two state stochastic learning automato (SLA) in a time shared model. Application of the hierarchical SLA to systems with multidimensional, multimodal performance criteria is described. Results of experiments performed with the hierarchical SLA using a performance index with a superimposed noise component of ? or - delta distributed uniformly over the surface are discussed.

  19. A hierarchical approach to the sustainable management of controlled ecological life support systems: part 2, systems realization and analysis.

    PubMed

    Pawlowski, C W; Auslander, D M

    2000-01-01

    The second in a series of two articles exploring the sustainable management of a controlled ecological life support system (CELSS), this article examines the feasibility of the approach outlined in Part 1 using a simple, abstract CELSS representation comprising buffers and pumps. We develop a two-level management hierarchy in which the top level imposes constraints on the operation of the lower level. The compartments can operate freely within these constraints. This freedom can be used to enhance system performance and robustness. Additionally, the higher level does not require detailed subsystem representations. Our approach to sustainable management of CELSS allows for the active distribution of system mass, taking into account component constraints and system dynamics.

  20. Sensing using eigenchannels in radio-frequency multiple-input, multiple-output communication systems

    NASA Astrophysics Data System (ADS)

    Bikhazi, Nicolas; Young, William F.; Nguyen, Hung

    2011-06-01

    This paper describes the use of multiple-input, multiple-output (MIMO) communication technology as a radio frequency (RF) sensor. We suggest some possible measures for determining how the changes in MIMO channel are related to objects moving through the MIMO channel. Initially, we examine the singular values of the channel matrix. We further demonstrate the effects of the signal-to-noise ratio (SNR) in conjunction with the target physical properties in the creation of eigenchannels. These eigenchannels represent the key factor in the ability of a MIMO system to perform as an effective sensor. Another important feature of MIMO technology is that it allows us to capture spatial information about the target, beyond the typical time and frequency information. Preliminary experimental results at 750 MHz demonstrate that targets can be detected and distinguished based on these simple measures. For example, a vehicular target is distinguishable from a person or groups of people. Our concept is closely related to a MIMO radar approach. However, a key difference is that we make use of the natural process of establishing a MIMO communication link rather than interrogate a specific physical region via a pulsed RF waveform. MIMO communications requires sounding of the physical environment and the creation of a channel matrix in order to maximize data throughput. We leverage this information about the area of interest already captured by the communication system. This allows the use of a MIMO system for both sensing and communication.

  1. Orbital Stability of Spacecraft Exploring Multiple Asteroid Systems

    NASA Astrophysics Data System (ADS)

    Burns, Keaton; Marchis, F.; Bellerose, J.

    2011-05-01

    Space missions to study the composition and formation histories of multiple asteroid systems require the identification of safe orbits for the observing spacecraft. To identify regions of orbital stability, we developed an n-body simulation and Monte Carlo scheme to test a large selection of orbits around the components of multiple asteroid systems. Our n-body program integrates the equations of motion of the spacecraft, asteroid system components, and the sun for 20 days, taking into account solar radiation pressure on the spacecraft and modeling asteroids as systems of rigid points when their shape model is known. We utilized a Monte Carlo scheme to test the stability of polar and retrograde orbits from uniformly distributed starting positions with normally distributed tangential velocities around each component. We present preliminary results of simulations testing hundreds of thousands of polar and retrograde orbits around the components of the 2001 SN263 near-earth triple asteroid system, and the (90) Antiope doublet and (45) Eugenia triple systems in the main-belt. These systems are potential targets for several space mission concepts, including: the Amor mission to visit and land on the components of 2001 SN263, Jones et al. (LPSC 42, #2695, 2011), the Diversity mission to explore several asteroid systems including (45) Eugenia and (90) Antiope, Marchis et al. (LPSC 42, #2062, 2011), and the ASTER mission to visit a NEA multiple asteroid, Sukhanov et al. (Cosmic Research 48-5, p. 443-450, 2010). Analysis of stable regions in position and velocity may assist in planning scientific orbits and instrumental specifications for such missions.

  2. Forever Alone? Testing Single Eccentric Planetary Systems for Multiple Companions

    NASA Astrophysics Data System (ADS)

    Wittenmyer, Robert A.; Wang, Songhu; Horner, Jonathan; Tinney, C. G.; Butler, R. P.; Jones, H. R. A.; O'Toole, S. J.; Bailey, J.; Carter, B. D.; Salter, G. S.; Wright, D.; Zhou, Ji-Lin

    2013-09-01

    Determining the orbital eccentricity of an extrasolar planet is critically important for understanding the system's dynamical environment and history. However, eccentricity is often poorly determined or entirely mischaracterized due to poor observational sampling, low signal-to-noise, and/or degeneracies with other planetary signals. Some systems previously thought to contain a single, moderate-eccentricity planet have been shown, after further monitoring, to host two planets on nearly circular orbits. We investigate published apparent single-planet systems to see if the available data can be better fit by two lower-eccentricity planets. We identify nine promising candidate systems and perform detailed dynamical tests to confirm the stability of the potential new multiple-planet systems. Finally, we compare the expected orbits of the single- and double-planet scenarios to better inform future observations of these interesting systems.

  3. FOREVER ALONE? TESTING SINGLE ECCENTRIC PLANETARY SYSTEMS FOR MULTIPLE COMPANIONS

    SciTech Connect

    Wittenmyer, Robert A.; Horner, Jonathan; Tinney, C. G.; Bailey, J.; Salter, G. S.; Wright, D.; Wang Songhu; Zhou Jilin; Butler, R. P.; Jones, H. R. A.; O'Toole, S. J.; Carter, B. D.

    2013-09-15

    Determining the orbital eccentricity of an extrasolar planet is critically important for understanding the system's dynamical environment and history. However, eccentricity is often poorly determined or entirely mischaracterized due to poor observational sampling, low signal-to-noise, and/or degeneracies with other planetary signals. Some systems previously thought to contain a single, moderate-eccentricity planet have been shown, after further monitoring, to host two planets on nearly circular orbits. We investigate published apparent single-planet systems to see if the available data can be better fit by two lower-eccentricity planets. We identify nine promising candidate systems and perform detailed dynamical tests to confirm the stability of the potential new multiple-planet systems. Finally, we compare the expected orbits of the single- and double-planet scenarios to better inform future observations of these interesting systems.

  4. Controlling dynamical systems using multiple delay feedback control

    NASA Astrophysics Data System (ADS)

    Ahlborn, Alexander; Parlitz, Ulrich

    2005-07-01

    Multiple delay feedback control (MDFC) with two, three, or four different and independent delay times is used to stabilize steady states of various chaotic dynamical systems. A comparison with delayed feedback control methods that are based on a single (fundamental) delay time [Pyragas’ time delay auto synchronization (TDAS) and extended TDAS] shows that MDFC is more effective for fixed point stabilization in terms of stability and flexibility, in particular for large delay times.

  5. System and process for pulsed multiple reaction monitoring

    DOEpatents

    Belov, Mikhail E

    2013-05-17

    A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.

  6. Computation of subsonic flow around airfoil systems with multiple separation

    NASA Technical Reports Server (NTRS)

    Jacob, K.

    1982-01-01

    A numerical method for computing the subsonic flow around multi-element airfoil systems was developed, allowing for flow separation at one or more elements. Besides multiple rear separation also sort bubbles on the upper surface and cove bubbles can approximately be taken into account. Also, compressibility effects for pure subsonic flow are approximately accounted for. After presentation the method is applied to several examples and improved in some details. Finally, the present limitations and desirable extensions are discussed.

  7. Advancing drug delivery systems for the treatment of multiple sclerosis.

    PubMed

    Tabansky, Inna; Messina, Mark D; Bangeranye, Catherine; Goldstein, Jeffrey; Blitz-Shabbir, Karen M; Machado, Suly; Jeganathan, Venkatesh; Wright, Paul; Najjar, Souhel; Cao, Yonghao; Sands, Warren; Keskin, Derin B; Stern, Joel N H

    2015-12-01

    Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. It is characterized by demyelination of neurons and loss of neuronal axons and oligodendrocytes. In MS, auto-reactive T cells and B cells cross the blood-brain barrier (BBB), causing perivenous demyelinating lesions that form multiple discrete inflammatory demyelinated plaques located primarily in the white matter. In chronic MS, cortical demyelination and progressive axonal transections develop. Treatment for MS can be stratified into disease-modifying therapies (DMTs) and symptomatic therapy. DMTs aim to decrease circulating immune cells or to prevent these cells from crossing the BBB and reduce the inflammatory response. There are currently 10 DMTs approved for the relapsing forms of MS; these vary with regard to their efficacy, route and frequency of administration, adverse effects, and toxicity profile. Better drug delivery systems are being developed in order to decrease adverse effects, increase drug efficacy, and increase patient compliance through the direct targeting of pathologic cells. Here, we address the uses and benefits of advanced drug delivery systems, including nanoparticles, microparticles, fusion antibodies, and liposomal formulations. By altering the properties of therapeutic particles and enhancing targeting, breakthrough drug delivery technologies potentially applicable to multiple disease treatments may rapidly emerge.

  8. Emergy evaluation of contrasting dairy systems at multiple levels.

    PubMed

    Vigne, Mathieu; Peyraud, Jean-Louis; Lecomte, Philippe; Corson, Michael S; Wilfart, Aurélie

    2013-11-15

    Emergy accounting (EmA) was applied to a range of dairy systems, from low-input smallholder systems in South Mali (SM), to intermediate-input systems in two regions of France, Poitou-Charentes (PC) and Bretagne (BR), to high-input systems on Reunion Island (RI). These systems were studied at three different levels: whole-farm (dairy system and cropping system), dairy-system (dairy herd and forage land), and herd (animals only). Dairy farms in SM used the lowest total emergy at all levels and was the highest user of renewable resources. Despite the low quality of resources consumed (crop residues and natural pasture), efficiency of their use was similar to that of industrialised inputs by intensive systems in RI, PC and BR. In addition, among the systems studied, SM dairy farms lay closest to environmental sustainability, contradicting the usual image of high environmental impact of cattle production in developing countries. EmA also revealed characteristics of the three intensive systems. Systems from RI and PC had lower resource transformation efficiency and higher environmental impacts than those from BR, due mainly to feeding strategies that differed due to differing socio-climatic constraints. Application of EmA at multiple levels revealed the importance of a multi-level analysis. While the whole-farm level assesses the overall contribution of the system to its environment, the dairy-system level is suitable for comparison of multi-product systems. In contrast, the herd level focuses on herd management and bypasses debates about definition of system boundaries by excluding land management. Combining all levels highlights the contribution of livestock to the global agricultural system and identifies inefficiencies and influences of system components on the environment. PMID:23792889

  9. Hierarchical features of large-scale cortical connectivity

    NASA Astrophysics Data System (ADS)

    da F. Costa, L.; Sporns, O.

    2005-12-01

    The analysis of complex networks has revealed patterns of organization in a variety of natural and artificial systems, including neuronal networks of the brain at multiple scales. In this paper, we describe a novel analysis of the large-scale connectivity between regions of the mammalian cerebral cortex, utilizing a set of hierarchical measurements proposed recently. We examine previously identified functional clusters of brain regions in macaque visual cortex and cat cortex and find significant differences between such clusters in terms of several hierarchical measures, revealing differences in how these clusters are embedded in the overall cortical architecture. For example, the ventral cluster of visual cortex maintains structurally more segregated, less divergent connections than the dorsal cluster, which may point to functionally different roles of their constituent brain regions.

  10. Performance analysis of commercial multiple-input-multiple-output access point in distributed antenna system.

    PubMed

    Fan, Yuting; Aighobahi, Anthony E; Gomes, Nathan J; Xu, Kun; Li, Jianqiang

    2015-03-23

    In this paper, we experimentally investigate the throughput of IEEE 802.11n 2x2 multiple-input-multiple-output (MIMO) signals in a radio-over-fiber-based distributed antenna system (DAS) with different fiber lengths and power imbalance. Both a MIMO-supported access point (AP) and a spatial-diversity-supported AP were separately employed in the experiments. Throughput measurements were carried out with wireless users at different locations in a typical office environment. For the different fiber length effect, the results indicate that MIMO signals can maintain high throughput when the fiber length difference between the two remote antenna units (RAUs) is under 100 m and falls quickly when the length difference is greater. For the spatial diversity signals, high throughput can be maintained even when the difference is 150 m. On the other hand, the separation of the MIMO antennas allows additional freedom in placing the antennas in strategic locations for overall improved system performance, although it may also lead to received power imbalance problems. The results show that the throughput performance drops in specific positions when the received power imbalance is above around 13 dB. Hence, there is a trade-off between the extent of the wireless coverage for moderate bit-rates and the area over which peak bit-rates can be achieved. PMID:25837089

  11. [The Multiple Sclerosis Documentation System MSDS. Discussion of a documentation standard for multiple sclerosis].

    PubMed

    Pette, M; Eulitz, M

    2002-02-01

    The MSDS (multiple sclerosis documentation system) has been developed at the Department of Neurology, Technical University of Dresden, Germany, during the last 4 years. The first version of this database application has been in use since October 2000. The MSDS manages information on MS patients, their treating physicians, patient history (symptoms, other diseases, biographical history, family history, habits, medication), clinical signs, results of laboratory examinations (blood chemistry, autoantibodies, borrelia serology, evoked potentials, cranial and spinal cord magnetic resonance imaging), clinical scores relevant for MS, and biosamples. In principle, MSDS allows online data input and semiautomatically generates reports to all general practitioners and neurologists treating the respective patient. Patient information sheets and internal treatment guidelines are part of the system. During a 3-month evaluation, the first version of MSDS was tested at eight university multiple sclerosis ambulatory care units and one general neurology hospital. The overall judgement was favorable. Suggestions for changes and improvements, as well as practical experiences, were considered when developing MSDS 2.0, which will be available by the end of 2001. PMID:11975090

  12. Performance analysis of commercial multiple-input-multiple-output access point in distributed antenna system.

    PubMed

    Fan, Yuting; Aighobahi, Anthony E; Gomes, Nathan J; Xu, Kun; Li, Jianqiang

    2015-03-23

    In this paper, we experimentally investigate the throughput of IEEE 802.11n 2x2 multiple-input-multiple-output (MIMO) signals in a radio-over-fiber-based distributed antenna system (DAS) with different fiber lengths and power imbalance. Both a MIMO-supported access point (AP) and a spatial-diversity-supported AP were separately employed in the experiments. Throughput measurements were carried out with wireless users at different locations in a typical office environment. For the different fiber length effect, the results indicate that MIMO signals can maintain high throughput when the fiber length difference between the two remote antenna units (RAUs) is under 100 m and falls quickly when the length difference is greater. For the spatial diversity signals, high throughput can be maintained even when the difference is 150 m. On the other hand, the separation of the MIMO antennas allows additional freedom in placing the antennas in strategic locations for overall improved system performance, although it may also lead to received power imbalance problems. The results show that the throughput performance drops in specific positions when the received power imbalance is above around 13 dB. Hence, there is a trade-off between the extent of the wireless coverage for moderate bit-rates and the area over which peak bit-rates can be achieved.

  13. Power margin improvement for OFDMA-PON using hierarchical modulation.

    PubMed

    Cao, Pan; Hu, Xiaofeng; Zhuang, Zhiming; Zhang, Liang; Chang, Qingjiang; Yang, Qi; Hu, Rong; Su, Yikai

    2013-04-01

    We propose and experimentally demonstrate a hierarchical modulation scheme to improve power margin for orthogonal frequency division multiple access-passive optical networks (OFDMA-PONs). In a PON system, under the same launched optical power, optical network units (ONUs) have different power margins due to unequal distribution fiber lengths. The power margin of the PON system is determined by the ONU with the lowest power margin. In our proposed scheme, ONUs with long and short distribution fibers are grouped together, and downstream signals for the paired ONUs are mapped onto the same OFDM subcarriers using hierarchical modulation. In a pair of ONUs, part of the power margin of the ONU with short distribution fiber is re-allocated to the ONU with long distribution fiber. Therefore, the power margin of the ONU with the longest distribution fiber can be increased, leading to the power margin improvement of the PON system. Experimental results show that the hierarchical modulation scheme improves the power margin by 2.7 dB for an OFDMA-PON system, which can be used to support more users or extend transmission distance.

  14. Presenting Multiple Drug Alerts in an Ambulatory Electronic Prescribing System

    PubMed Central

    Weinger, M.B.; Gregg, W.M.; Johnson, K.B.

    2014-01-01

    Summary Objective This study explores alternative approaches to the display of drug alerts, and examines whether and how human-factors based interface design can be used to improve the prescriber’s perception about drug alert presentation, signal detection from noisy alert data, and their comprehension of clinical decision support during electronic prescribing. Methods We reviewed issues with presenting multiple drug alerts in electronic prescribing systems. User-centered design, consisting of iterative usability and prototype testing was applied. After an iterative design phase, we proposed several novel drug alert presentation interfaces; expert evaluation and formal usability testing were applied to access physician prescribers’ perceptions of the tools. We mapped drug alert attributes to different interface constructs. We examined four different interfaces for presenting multiple drug alerts. Results A TreeDashboard View was better perceived than a text-based ScrollText View with respect to the ability to detect critical information, the ability to accomplish tasks, and the perceptional efficacy of finding information. Conclusion A robust model for studying multiple drug-alert presentations was developed. Several drug alert presentation interfaces were proposed. The TreeDashboard View was better perceived than the text-based ScrollText View in delivering multiple drug alerts during a simulation of electronic prescribing. PMID:25024753

  15. A comparison of hierarchical cluster analysis and league table rankings as methods for analysis and presentation of district health system performance data in Uganda.

    PubMed

    Tashobya, Christine K; Dubourg, Dominique; Ssengooba, Freddie; Speybroeck, Niko; Macq, Jean; Criel, Bart

    2016-03-01

    In 2003, the Uganda Ministry of Health introduced the district league table for district health system performance assessment. The league table presents district performance against a number of input, process and output indicators and a composite index to rank districts. This study explores the use of hierarchical cluster analysis for analysing and presenting district health systems performance data and compares this approach with the use of the league table in Uganda. Ministry of Health and district plans and reports, and published documents were used to provide information on the development and utilization of the Uganda district league table. Quantitative data were accessed from the Ministry of Health databases. Statistical analysis using SPSS version 20 and hierarchical cluster analysis, utilizing Wards' method was used. The hierarchical cluster analysis was conducted on the basis of seven clusters determined for each year from 2003 to 2010, ranging from a cluster of good through moderate-to-poor performers. The characteristics and membership of clusters varied from year to year and were determined by the identity and magnitude of performance of the individual variables. Criticisms of the league table include: perceived unfairness, as it did not take into consideration district peculiarities; and being oversummarized and not adequately informative. Clustering organizes the many data points into clusters of similar entities according to an agreed set of indicators and can provide the beginning point for identifying factors behind the observed performance of districts. Although league table ranking emphasize summation and external control, clustering has the potential to encourage a formative, learning approach. More research is required to shed more light on factors behind observed performance of the different clusters. Other countries especially low-income countries that share many similarities with Uganda can learn from these experiences.

  16. Wireline system for multiple direct push tool usage

    SciTech Connect

    Bratton, Wesley L.; Farrington, Stephen P.; Shinn, II, James D.; Nolet, Darren C.

    2003-11-11

    A tool latching and retrieval system allows the deployment and retrieval of a variety of direct push subsurface characterization tools through an embedded rod string during a single penetration without requiring withdrawal of the string from the ground. This enables the in situ interchange of different tools, as well as the rapid retrieval of soil core samples from multiple depths during a single direct push penetration. The system includes specialized rods that make up the rod string, a tool housing which is integral to the rod string, a lock assembly, and several tools which mate to the lock assembly.

  17. Solutions on high-resolution multiple configuration system sensors

    NASA Astrophysics Data System (ADS)

    Liu, Hua; Ding, Quanxin; Guo, Chunjie; Zhou, Liwei

    2014-11-01

    For aim to achieve an improved resolution in modern image domain, a method of continuous zoom multiple configuration, with a core optics is attempt to establish model by novel principle on energy transfer and high accuracy localization, by which the system resolution can be improved with a level in nano meters. A comparative study on traditional vs modern methods can demonstrate that the dialectical relationship and their balance is important, among Merit function, Optimization algorithms and Model parameterization. The effect of system evaluated criterion that MTF, REA, RMS etc. can support our arguments qualitatively.

  18. Tunable multiple mode-splitting in coupled graphene resonators system

    NASA Astrophysics Data System (ADS)

    Wang, Jicheng; Xia, Xiushan; Wang, Xiaosai; Liu, Shutian

    2016-05-01

    We investigate a coupled graphene resonator system which exhibits multiple mode-splitting effects and electromagnetically-induced-absorption-like transmission. The finite element method has been employed to study the transmission and electromagnetic responses of our designs at mid-infrared frequency. According to simulation results, the mode-splitting effects are mainly dependent on the destructive interference between two graphene resonators. By varying the chemical potential of graphene or the coupling gap, we are accessible to achieve a dynamically controllable mode-splitting system serving as a sensing application.

  19. Multiple well systems with non-Darcy flow.

    PubMed

    Mijic, Ana; Mathias, Simon A; LaForce, Tara C

    2013-01-01

    Optimization of groundwater and other subsurface resources requires analysis of multiple-well systems. The usual modeling approach is to apply a linear flow equation (e.g., Darcy's law in confined aquifers). In such conditions, the composite response of a system of wells can be determined by summating responses of the individual wells (the principle of superposition). However, if the flow velocity increases, the nonlinear losses become important in the near-well region and the principle of superposition is no longer valid. This article presents an alternative method for applying analytical solutions of non-Darcy flow for a single- to multiple-well systems. The method focuses on the response of the central injection well located in an array of equally spaced wells, as it is the well that exhibits the highest pressure change within the system. This critical well can be represented as a single well situated in the center of a closed square domain, the width of which is equal to the well spacing. It is hypothesized that a single well situated in a circular region of the equivalent plan area adequately represents such a system. A test case is presented and compared with a finite-difference solution for the original problem, assuming that the flow is governed by the nonlinear Forchheimer equation. PMID:23039097

  20. Multiple parallel memory systems in the brain of the rat.

    PubMed

    White, Norman M; McDonald, Robert J

    2002-03-01

    A theory of multiple parallel memory systems in the brain of the rat is described. Each system consists of a series of interconnected neural structures. The "central structures" of the three systems described are the hippocampus, the matrix compartment of the dorsal striatum (caudate-putamen), and the amygdala. Information, coded as neural signals, flows independently through each system. All systems have access to the same information from situations in which learning occurs, but each system is specialized to represent a different kind of relationship among the elements (stimulus events, responses, reinforcers) of the information that flows through it. The speed and accuracy with which a system forms a coherent representation of a learning situation depend on the correspondence between the specialization of the system and the relationship among the elements of the situation. The coherence of these stored representations determines the degree of control exerted by each system on behavior in the situation. Although they process information independently the systems interact in at least two ways: by simultaneous parallel influence on behavioral output and by directly influencing each other. These interactions can be cooperative (leading to similar behaviors) or competitive (leading to different behaviors). Experimental findings consistent with these ideas, mostly from experiments with rats, are reviewed.

  1. Hierarchical Linked Views

    SciTech Connect

    Erbacher, Robert; Frincke, Deb

    2007-07-02

    Coordinated views have proven critical to the development of effective visualization environments. This results from the fact that a single view or representation of the data cannot show all of the intricacies of a given data set. Additionally, users will often need to correlate more data parameters than can effectively be integrated into a single visual display. Typically, development of multiple-linked views results in an adhoc configuration of views and associated interactions. The hierarchical model we are proposing is geared towards more effective organization of such environments and the views they encompass. At the same time, this model can effectively integrate much of the prior work on interactive and visual frameworks. Additionally, we expand the concept of views to incorporate perceptual views. This is related to the fact that visual displays can have information encoded at various levels of focus. Thus, a global view of the display provides overall trends of the data while focusing in on individual elements provides detailed specifics. By integrating interaction and perception into a single model, we show how one impacts the other. Typically, interaction and perception are considered separately, however, when interaction is being considered at a fundamental level and allowed to direct/modify the visualization directly we must consider them simultaneously and how they impact one another.

  2. Bioerodible System for Sequential Release of Multiple Drugs

    PubMed Central

    Sundararaj, Sharath C.; Thomas, Mark V.; Dziubla, Thomas D.; Puleo, David A.

    2013-01-01

    Because many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P). After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices. Drug release from single-layered CAPP films followed zero-order kinetics related to surface erosion of the association polymer. Release studies from multilayered CAPP devices showed the possibility of achieving intermittent release of one type of drug as well as sequential release of more than one type of drug. Mathematical modeling accurately predicted the release profiles for both single layer and multilayered devices. The present CAPP association polymer-based multilayer devices can be used for localized, sequential delivery of multiple drugs for the possible treatment of complex disease conditions, and perhaps for tissue engineering applications, that require delivery of more than one type of biomolecule. PMID:24096151

  3. Bioerodible system for sequential release of multiple drugs.

    PubMed

    Sundararaj, Sharath C; Thomas, Mark V; Dziubla, Thomas D; Puleo, David A

    2014-01-01

    Because many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P). After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices. Drug release from single-layered CAPP films followed zero-order kinetics related to surface erosion of the association polymer. Release studies from multilayered CAPP devices showed the possibility of achieving intermittent release of one type of drug as well as sequential release of more than one type of drug. Mathematical modeling accurately predicted the release profiles for both single layer and multilayered devices. The present CAPP association polymer-based multilayer devices can be used for localized, sequential delivery of multiple drugs for the possible treatment of complex disease conditions, and perhaps for tissue engineering applications, that require delivery of more than one type of biomolecule. PMID:24096151

  4. Problem of two-level hierarchical minimax program control the final state of regional social and economic system in the presence of risks

    SciTech Connect

    Shorikov, A. F.

    2015-11-30

    This article discusses a discrete-time dynamical system consisting of a set a controllable objects (region and forming it municipalities). The dynamics each of these is described by the corresponding vector nonlinear discrete-time recurrent vector equations and its control system consist from two levels: basic (control level I) that is dominating and subordinate level (control level II). Both levels have different criterions of functioning and united a priori by determined informational and control connections defined in advance. In this paper we study the problem of optimization of guaranteed result for program control by the final state of regional social and economic system in the presence of risks. For this problem we proposed in this work an economical and mathematical model of two-level hierarchical minimax program control the final state of regional social and economic system in the presence of risks and the general scheme for its solving.

  5. Effective field theories for superconducting systems with multiple Fermi surfaces

    NASA Astrophysics Data System (ADS)

    Braga, P. R.; Granado, D. R.; Guimaraes, M. S.; Wotzasek, C.

    2016-11-01

    In this work we investigate the description of superconducting systems with multiple Fermi surfaces. For the case of one Fermi surface we re-obtain the result that the superconductor is more precisely described as a topological state of matter. Studying the case of more than one Fermi surface, we obtain the effective theory describing a time reversal symmetric topological superconductor. These results are obtained by employing a general procedure to construct effective low energy actions describing states of electromagnetic systems interacting with charges and defects. The procedure consists in taking into account the proliferation or dilution of these charges and defects and its consequences for the low energy description of the electromagnetic response of the system. We find that the main ingredient entering the low energy characterization of the system with more than one Fermi surface is a non-conservation of the canonical supercurrent triggered by particular vortex configurations.

  6. System and method for inventorying multiple remote objects

    DOEpatents

    Carrender, Curtis L.; Gilbert, Ronald W.

    2009-12-29

    A system and method of inventorying multiple objects utilizing a multi-level or a chained radio frequency identification system. The system includes a master tag and a plurality of upper level tags and lower level tags associated with respective objects. The upper and lower level tags communicate with each other and the master tag so that reading of the master tag reveals the presence and absence of upper and lower level tags. In the chained RF system, the upper and lower level tags communicate locally with each other in a manner so that more remote tags that are out of range of some of the upper and lower level tags have their information relayed through adjacent tags to the master tag and thence to a controller.

  7. System and method for inventorying multiple remote objects

    DOEpatents

    Carrender, Curtis L.; Gilbert, Ronald W.

    2007-10-23

    A system and method of inventorying multiple objects utilizing a multi-level or a chained radio frequency identification system. The system includes a master tag and a plurality of upper level tags and lower level tags associated with respective objects. The upper and lower level tags communicate with each other and the master tag so that reading of the master tag reveals the presence and absence of upper and lower level tags. In the chained RF system, the upper and lower level tags communicate locally with each other in a manner so that more remote tags that are out of range of some of the upper and lower level tags have their information relayed through adjacent tags to the master tag and thence to a controller.

  8. Multiple fuel supply system for an internal combustion engine

    DOEpatents

    Crothers, William T.

    1977-01-01

    A multiple fuel supply or an internal combustion engine wherein phase separation of components is deliberately induced. The resulting separation permits the use of a single fuel tank to supply components of either or both phases to the engine. Specifically, phase separation of a gasoline/methanol blend is induced by the addition of a minor amount of water sufficient to guarantee separation into an upper gasoline phase and a lower methanol/water phase. A single fuel tank holds the two-phase liquid with separate fuel pickups and separate level indicators for each phase. Either gasoline or methanol, or both, can be supplied to the engine as required by predetermined parameters. A fuel supply system for a phase-separated multiple fuel supply contained in a single fuel tank is described.

  9. Simultaneous real-time monitoring of multiple cortical systems

    NASA Astrophysics Data System (ADS)

    Gupta, Disha; Hill, N. Jeremy; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Schalk, Gerwin

    2014-10-01

    Objective. Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach. We study these questions using electrocorticographic signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (six for offline parameter optimization, six for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results. Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelopes. These decoders were trained separately and executed simultaneously in real time. Significance. This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple

  10. MACSIMS : multiple alignment of complete sequences information management system

    PubMed Central

    Thompson, Julie D; Muller, Arnaud; Waterhouse, Andrew; Procter, Jim; Barton, Geoffrey J; Plewniak, Frédéric; Poch, Olivier

    2006-01-01

    Background In the post-genomic era, systems-level studies are being performed that seek to explain complex biological systems by integrating diverse resources from fields such as genomics, proteomics or transcriptomics. New information management systems are now needed for the collection, validation and analysis of the vast amount of heterogeneous data available. Multiple alignments of complete sequences provide an ideal environment for the integration of this information in the context of the protein family. Results MACSIMS is a multiple alignment-based information management program that combines the advantages of both knowledge-based and ab initio sequence analysis methods. Structural and functional information is retrieved automatically from the public databases. In the multiple alignment, homologous regions are identified and the retrieved data is evaluated and propagated from known to unknown sequences with these reliable regions. In a large-scale evaluation, the specificity of the propagated sequence features is estimated to be >99%, i.e. very few false positive predictions are made. MACSIMS is then used to characterise mutations in a test set of 100 proteins that are known to be involved in human genetic diseases. The number of sequence features associated with these proteins was increased by 60%, compared to the features available in the public databases. An XML format output file allows automatic parsing of the MACSIM results, while a graphical display using the JalView program allows manual analysis. Conclusion MACSIMS is a new information management system that incorporates detailed analyses of protein families at the structural, functional and evolutionary levels. MACSIMS thus provides a unique environment that facilitates knowledge extraction and the presentation of the most pertinent information to the biologist. A web server and the source code are available at . PMID:16792820

  11. Charging system with galvanic isolation and multiple operating modes

    DOEpatents

    Kajouke, Lateef A.; Perisic, Milun; Ransom, Ray M.

    2013-01-08

    Systems and methods are provided for operating a charging system with galvanic isolation adapted for multiple operating modes. A vehicle charging system comprises a DC interface, an AC interface, a first conversion module coupled to the DC interface, and a second conversion module coupled to the AC interface. An isolation module is coupled between the first conversion module and the second conversion module. The isolation module comprises a transformer and a switching element coupled between the transformer and the second conversion module. The transformer and the switching element are cooperatively configured for a plurality of operating modes, wherein each operating mode of the plurality of operating modes corresponds to a respective turns ratio of the transformer.

  12. Thermodynamics of quantum systems with multiple conserved quantities

    NASA Astrophysics Data System (ADS)

    Guryanova, Yelena; Popescu, Sandu; Short, Anthony J.; Silva, Ralph; Skrzypczyk, Paul

    2016-07-01

    Recently, there has been much progress in understanding the thermodynamics of quantum systems, even for small individual systems. Most of this work has focused on the standard case where energy is the only conserved quantity. Here we consider a generalization of this work to deal with multiple conserved quantities. Each conserved quantity, which, importantly, need not commute with the rest, can be extracted and stored in its own battery. Unlike the standard case, in which the amount of extractable energy is constrained, here there is no limit on how much of any individual conserved quantity can be extracted. However, other conserved quantities must be supplied, and the second law constrains the combination of extractable quantities and the trade-offs between them. We present explicit protocols that allow us to perform arbitrarily good trade-offs and extract arbitrarily good combinations of conserved quantities from individual quantum systems.

  13. Thermodynamics of quantum systems with multiple conserved quantities.

    PubMed

    Guryanova, Yelena; Popescu, Sandu; Short, Anthony J; Silva, Ralph; Skrzypczyk, Paul

    2016-01-01

    Recently, there has been much progress in understanding the thermodynamics of quantum systems, even for small individual systems. Most of this work has focused on the standard case where energy is the only conserved quantity. Here we consider a generalization of this work to deal with multiple conserved quantities. Each conserved quantity, which, importantly, need not commute with the rest, can be extracted and stored in its own battery. Unlike the standard case, in which the amount of extractable energy is constrained, here there is no limit on how much of any individual conserved quantity can be extracted. However, other conserved quantities must be supplied, and the second law constrains the combination of extractable quantities and the trade-offs between them. We present explicit protocols that allow us to perform arbitrarily good trade-offs and extract arbitrarily good combinations of conserved quantities from individual quantum systems. PMID:27384384

  14. Multiple pulmonary hyalinizing granulomas associated with systemic idiopathic fibrosis.

    PubMed

    Kuramochi, S; Kawai, T; Yakumaru, K; Mikata, A; Torikata, C; Kasuga, Y; Fujiwara, T

    1991-05-01

    A 41-year-old man with progressive nodular infiltration of the lung of about 2 years' duration died of cardiac and respiratory failure. Autopsy revealed bilateral multiple pulmonary hyalinizing granulomas (PHGs) diagnosed on the basis of the characteristic dense hyaline collagen bundles with nonspecific inflammatory infiltration. Constrictive pericarditis, retroperitoneal fibrosis, mediastinal fibrosis, fibrous thickening of the peritoneal and pleural surfaces, and fibrosis of soft tissue of the neck, flank, and hepatic hilar region were present, therefore, a diagnosis of systemic idiopathic fibrosis was made. The patient had anti-thyroglobulin and anti-thyroid microsomal antibodies and lymphocytic thyroiditis. The inflammatory process of PHG of the present case was active and the clinical course was progressive. PHG seems to be a lesion belonging to the systemic idiopathic fibrosis complex. Immunologic abnormalities may be related to PHG and systemic idiopathic fibrosis. PMID:1714226

  15. Comparing fault susceptibility of multiple ISAs and operating systems

    NASA Astrophysics Data System (ADS)

    Chyłek, Sławomir

    2015-09-01

    This paper presents a research that aims to compare effects of faults on different configurations of computer systems. The study covers comparison of susceptibility to faults of x86, AMD64, ARM, PowerPC, MIPS architectures and Linux, FreeBSD, Minix operating systems. An emulation based software implemented fault injection technique was used to perform experiments. The problem of choosing an adequate number of tests in experiments is followed by report with collected results where multiple aspects of test runs were analyzed: providing correct computation result, availability of the system under test and error messages. The research allows to determine characteristics of susceptibility to faults of each platform and is a first step towards designing new fault tolerance solutions and assessing their effectiveness.

  16. Thermodynamics of quantum systems with multiple conserved quantities

    PubMed Central

    Guryanova, Yelena; Popescu, Sandu; Short, Anthony J.; Silva, Ralph; Skrzypczyk, Paul

    2016-01-01

    Recently, there has been much progress in understanding the thermodynamics of quantum systems, even for small individual systems. Most of this work has focused on the standard case where energy is the only conserved quantity. Here we consider a generalization of this work to deal with multiple conserved quantities. Each conserved quantity, which, importantly, need not commute with the rest, can be extracted and stored in its own battery. Unlike the standard case, in which the amount of extractable energy is constrained, here there is no limit on how much of any individual conserved quantity can be extracted. However, other conserved quantities must be supplied, and the second law constrains the combination of extractable quantities and the trade-offs between them. We present explicit protocols that allow us to perform arbitrarily good trade-offs and extract arbitrarily good combinations of conserved quantities from individual quantum systems. PMID:27384384

  17. Multiple-Point Mass Flux Measurement System Using Rayleigh Scattering

    NASA Technical Reports Server (NTRS)

    Mielke, Amy F.; Elam, Kristie A.; Clem, Michelle M.

    2009-01-01

    A multiple-point Rayleigh scattering diagnostic is being developed to provide mass flux measurements in gas flows. Spectroscopic Rayleigh scattering is an established flow diagnostic that has the ability to provide simultaneous density, temperature, and velocity measurements. Rayleigh scattered light from a focused 18 Watt continuous-wave laser beam is directly imaged through a solid Fabry-Perot etalon onto a CCD detector which permits spectral analysis of the light. The spatial resolution of the measurements is governed by the locations of interference fringes, which can be changed by altering the etalon characteristics. A prototype system has been used to acquire data in a Mach 0.56 flow to demonstrate feasibility of using this system to provide mass flux measurements. Estimates of measurement uncertainty and recommendations for system improvements are presented

  18. Multiple brain atlas database and atlas-based neuroimaging system.

    PubMed

    Nowinski, W L; Fang, A; Nguyen, B T; Raphel, J K; Jagannathan, L; Raghavan, R; Bryan, R N; Miller, G A

    1997-01-01

    For the purpose of developing multiple, complementary, fully labeled electronic brain atlases and an atlas-based neuroimaging system for analysis, quantification, and real-time manipulation of cerebral structures in two and three dimensions, we have digitized, enhanced, segmented, and labeled the following print brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach and Tournoux, Atlas for Stereotaxy of the Human Brain by Schaltenbrand and Wahren, Referentially Oriented Cerebral MRI Anatomy by Talairach and Tournoux, and Atlas of the Cerebral Sulci by Ono, Kubik, and Abernathey. Three-dimensional extensions of these atlases have been developed as well. All two- and three-dimensional atlases are mutually preregistered and may be interactively registered with an actual patient's data. An atlas-based neuroimaging system has been developed that provides support for reformatting, registration, visualization, navigation, image processing, and quantification of clinical data. The anatomical index contains about 1,000 structures and over 400 sulcal patterns. Several new applications of the brain atlas database also have been developed, supported by various technologies such as virtual reality, the Internet, and electronic publishing. Fusion of information from multiple atlases assists the user in comprehensively understanding brain structures and identifying and quantifying anatomical regions in clinical data. The multiple brain atlas database and atlas-based neuroimaging system have substantial potential impact in stereotactic neurosurgery and radiotherapy by assisting in visualization and real-time manipulation in three dimensions of anatomical structures, in quantitative neuroradiology by allowing interactive analysis of clinical data, in three-dimensional neuroeducation, and in brain function studies.

  19. The role of information system in multiple sclerosis management

    PubMed Central

    Ajami, Sima; Ahmadi, Golchehreh; Etemadifar, Masoud

    2014-01-01

    Multiple sclerosis (MS) is a chronic disease of central nervous system. The multiple sclerosis information system (MSIS), such as other information system (IS), depends on identification, collection and processing of data for producing useful information. Lack of the integrated IS for collecting standard data causes undesirable effects on exchanging, comparing, and managing. The aim of this study was to recognize the role of the IS in the MS management and determine the advantages and barriers in implementing of the MSIS. The present study was a nonsystematized review that was done in order to recognize the role of the IS in the MS management. In this study, electronic scientific resources such as scientific magazines and books and published topics at conferences were used. We used key words (IS, chronic disease management, and multiple sclerosis), their combination or their synonyms in title, key words, abstracts, and text of English articles and published reports from 1980 until 2013, and by using search engines such as Google, Google Scholar and scientific databases and electronic issues such as iPubMed, sufficiently important difference, Scopus, Medlib, and Magiran for gathering information. More than 200 articles and reports were collected and assessed and 139 of them. Findings showed that the MSIS can reduce of disease expenses through continuously collecting correct, accurate, sufficient, and timely patients and disease nature information; recoding; editing; processing; exchanging, and distributing among different health care centers. Although the MSIS has many advantages; but, we cannot ignore cultural, economic, technical, organizational, and managerial barriers. Therefore, it is necessary to do studies for preventing, reducing, and controlling them. One of the ways is to recognize the advantages of the MSIS and usage information technology in optimizing disease management. PMID:25709660

  20. The role of information system in multiple sclerosis management.

    PubMed

    Ajami, Sima; Ahmadi, Golchehreh; Etemadifar, Masoud

    2014-12-01

    Multiple sclerosis (MS) is a chronic disease of central nervous system. The multiple sclerosis information system (MSIS), such as other information system (IS), depends on identification, collection and processing of data for producing useful information. Lack of the integrated IS for collecting standard data causes undesirable effects on exchanging, comparing, and managing. The aim of this study was to recognize the role of the IS in the MS management and determine the advantages and barriers in implementing of the MSIS. The present study was a nonsystematized review that was done in order to recognize the role of the IS in the MS management. In this study, electronic scientific resources such as scientific magazines and books and published topics at conferences were used. We used key words (IS, chronic disease management, and multiple sclerosis), their combination or their synonyms in title, key words, abstracts, and text of English articles and published reports from 1980 until 2013, and by using search engines such as Google, Google Scholar and scientific databases and electronic issues such as iPubMed, sufficiently important difference, Scopus, Medlib, and Magiran for gathering information. More than 200 articles and reports were collected and assessed and 139 of them. Findings showed that the MSIS can reduce of disease expenses through continuously collecting correct, accurate, sufficient, and timely patients and disease nature information; recoding; editing; processing; exchanging, and distributing among different health care centers. Although the MSIS has many advantages; but, we cannot ignore cultural, economic, technical, organizational, and managerial barriers. Therefore, it is necessary to do studies for preventing, reducing, and controlling them. One of the ways is to recognize the advantages of the MSIS and usage information technology in optimizing disease management.

  1. Lung function measurement with multiple-breath-helium washout system.

    PubMed

    Wang, J-Y; Suddards, M E; Mellor, C J; Owers-Bradley, J R

    2013-04-01

    Multiple-breath-washout (MBW) measurements are regarded as a sensitive technique which can reflect the ventilation inhomogeneity of respiratory airways. Typically nitrogen is used as the tracer gas and is washed out by pure oxygen in multiple-breath-nitrogen washout (MBNW) tests. In this study, instead of using nitrogen, (4)He is used as the tracer gas with smaller gas density which may be able to reach deeper into our lungs in a given time and the helium washout results may be more sensitive to the ventilation inhomogeneity in small airways. A multiple-breath-helium-washout (MBHW) system developed for the lung function study is also presented. Quartz tuning forks with a resonance frequency of 32,768Hz have been used for detecting the change of the respiratory gas density. The resonance frequency of the quartz tuning fork decreases linearly with increasing density of the surrounding gas. Knowing the CO2 concentration from the infrared carbon dioxide detector, the helium concentration can be determined. Results from 14 volunteers (3 mild asthmatics, 4 tobacco smokers, 1 with asthma history, 1 with COPD history, 5 normal) have shown that mild asthmatics have higher ventilation inhomogeneity in either conducting or acinar airways (or both). A feature has been found in washout curve of single breaths from 4 tobacco smokers with different length of smoking history which may indicate the early stage of respiratory ventilation inhomogeneity in acinar airways.

  2. A color based face detection system using multiple templates.

    PubMed

    Wang, Tao; Bu, Jia-Jun; Chen, Chun

    2003-01-01

    A color based system using multiple templates was developed and implemented for detecting human faces in color images. The algorithm consists of three image processing steps. The first step is human skin color statistics. Then it separates skin regions from non-skin regions. After that, it locates the frontal human face(s) within the skin regions. In the first step, 250 skin samples from persons of different ethnicities are used to determine the color distribution of human skin in chromatic color space in order to get a chroma chart showing likelihoods of skin colors. This chroma chart is used to generate, from the original color image, a gray scale image whose gray value at a pixel shows its likelihood of representing the skin. The algorithm uses an adaptive thresholding process to achieve the optimal threshold value for dividing the gray scale image into separate skin regions from non skin regions. Finally, multiple face templates matching is used to determine if a given skin region represents a frontal human face or not. Test of the system with more than 400 color images showed that the resulting detection rate was 83%, which is better than most color-based face detection systems. The average speed for face detection is 0.8 second/image (400 x 300 pixels) on a Pentium 3 (800MHz) PC.

  3. Multiprocessor system with multiple concurrent modes of execution

    SciTech Connect

    Ahn, Daniel; Ceze, Luis H; Chen, Dong; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

    2013-12-31

    A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

  4. Hierarchical Nanoceramics for Industrial Process Sensors

    SciTech Connect

    Ruud, James, A.; Brosnan, Kristen, H.; Striker, Todd; Ramaswamy, Vidya; Aceto, Steven, C.; Gao, Yan; Willson, Patrick, D.; Manoharan, Mohan; Armstrong, Eric, N., Wachsman, Eric, D.; Kao, Chi-Chang

    2011-07-15

    This project developed a robust, tunable, hierarchical nanoceramics materials platform for industrial process sensors in harsh-environments. Control of material structure at multiple length scales from nano to macro increased the sensing response of the materials to combustion gases. These materials operated at relatively high temperatures, enabling detection close to the source of combustion. It is anticipated that these materials can form the basis for a new class of sensors enabling widespread use of efficient combustion processes with closed loop feedback control in the energy-intensive industries. The first phase of the project focused on materials selection and process development, leading to hierarchical nanoceramics that were evaluated for sensing performance. The second phase focused on optimizing the materials processes and microstructures, followed by validation of performance of a prototype sensor in a laboratory combustion environment. The objectives of this project were achieved by: (1) synthesizing and optimizing hierarchical nanostructures; (2) synthesizing and optimizing sensing nanomaterials; (3) integrating sensing functionality into hierarchical nanostructures; (4) demonstrating material performance in a sensing element; and (5) validating material performance in a simulated service environment. The project developed hierarchical nanoceramic electrodes for mixed potential zirconia gas sensors with increased surface area and demonstrated tailored electrocatalytic activity operable at high temperatures enabling detection of products of combustion such as NOx close to the source of combustion. Methods were developed for synthesis of hierarchical nanostructures with high, stable surface area, integrated catalytic functionality within the structures for gas sensing, and demonstrated materials performance in harsh lab and combustion gas environments.

  5. NASA Thesaurus. Volume 1: Hierarchical listing

    NASA Technical Reports Server (NTRS)

    1982-01-01

    There are 16,713 postable terms and 3,716 nonpostable terms approved for use in the NASA scientific and technical information system in the Hierarchical Listing of the NASA Thesaurus. The generic structure is presented for many terms. The broader term and narrower term relationships are shown in an indented fashion that illustrates the generic structure better than the more widely used BT and NT listings. Related terms are generously applied, thus enhancing the usefulness of the Hierarchical Listing. Greater access to the Hierarchical Listing may be achieved with the collateral use of Volume 2 - Access Vocabulary.

  6. NASA thesaurus. Volume 1: Hierarchical listing

    NASA Technical Reports Server (NTRS)

    1985-01-01

    There are 16,835 postable terms and 3,765 nonpostable terms approved for use in the NASA scientific and technical information system in the Hierarchical Listing of the NASA Thesaurus. The generic structure is presented for many terms. The broader term and narrower term relationships are shown in an indented fashion that illustrates the generic structure better than the more widely used BT and NT listings. Related terms are generously applied, thus enhancing the usefulness of the Hierarchical Listing. Greater access to the Hierarchical Listing may be achieved with the collateral use of Volume 2 - Access Vocabulary.

  7. NASA thesaurus. Volume 1: Hierarchical Listing

    NASA Technical Reports Server (NTRS)

    1988-01-01

    There are over 17,000 postable terms and nearly 4,000 nonpostable terms approved for use in the NASA scientific and technical information system in the Hierarchical Listing of the NASA Thesaurus. The generic structure is presented for many terms. The broader term and narrower term relationships are shown in an indented fashion that illustrates the generic structure better than the more widely used BT and NT listings. Related terms are generously applied, thus enhancing the usefulness of the Hierarchical Listing. Greater access to the Hierarchical Listing may be achieved with the collateral use of Volume 2 - Access Vocabulary and Volume 3 - Definitions.

  8. Onboard hierarchical network

    NASA Astrophysics Data System (ADS)

    Tunesi, Luca; Armbruster, Philippe

    2004-02-01

    The objective of this paper is to demonstrate a suitable hierarchical networking solution to improve capabilities and performances of space systems, with significant recurrent costs saving and more efficient design & manufacturing flows. Classically, a satellite can be split in two functional sub-systems: the platform and the payload complement. The platform is in charge of providing power, attitude & orbit control and up/down-link services, whereas the payload represents the scientific and/or operational instruments/transponders and embodies the objectives of the mission. One major possibility to improve the performance of payloads, by limiting the data return to pertinent information, is to process data on board thanks to a proper implementation of the payload data system. In this way, it is possible to share non-recurring development costs by exploiting a system that can be adopted by the majority of space missions. It is believed that the Modular and Scalable Payload Data System, under development by ESA, provides a suitable solution to fulfil a large range of future mission requirements. The backbone of the system is the standardised high data rate SpaceWire network http://www.ecss.nl/. As complement, a lower speed command and control bus connecting peripherals is required. For instance, at instrument level, there is a need for a "local" low complexity bus, which gives the possibility to command and control sensors and actuators. Moreover, most of the connections at sub-system level are related to discrete signals management or simple telemetry acquisitions, which can easily and efficiently be handled by a local bus. An on-board hierarchical network can therefore be defined by interconnecting high-speed links and local buses. Additionally, it is worth stressing another important aspect of the design process: Agencies and ESA in particular are frequently confronted with a big consortium of geographically spread companies located in different countries, each one

  9. Studies of multiple stellar systems - IV. The triple-lined spectroscopic system Gliese 644

    NASA Astrophysics Data System (ADS)

    Mazeh, Tsevi; Latham, David W.; Goldberg, Elad; Torres, Guillermo; Stefanik, Robert P.; Henry, Todd J.; Zucker, Shay; Gnat, Orly; Ofek, Eran O.

    2001-07-01

    We present a radial velocity study of the triple-lined system Gliese 644 and derive spectroscopic elements for the inner and outer orbits with periods of 2.9655 and 627d. We also utilize old visual data, as well as modern speckle and adaptive optics observations, to derive a new astrometric solution for the outer orbit. These two orbits together allow us to derive masses for each of the three components in the system: MA=0.410+/-0.028 (6.9 per cent), MBa=0.336+/-0.016 (4.7 per cent), and MBb=0.304+/-0.014 (4.7 per cent)Msolar. We suggest that the relative inclination of the two orbits is very small. Our individual masses and spectroscopic light ratios for the three M stars in the Gliese 644 system provide three points for the mass-luminosity relation near the bottom of the main sequence, where the relation is poorly determined. These three points agree well with theoretical models for solar metallicity and an age of 5Gyr. Our radial velocities for Gliese 643 and vB 8, two common proper motion companions of Gliese 644, support the interpretation that all five M stars are moving together in a physically bound group. We discuss possible scenarios for the formation and evolution of this configuration, such as the formation of all five stars in a sequence of fragmentation events leading directly to the hierarchical configuration now observed, versus formation in a small N cluster with subsequent dynamical evolution into the present hierarchical configuration.

  10. Multiple-Flat-Panel System Displays Multidimensional Data

    NASA Technical Reports Server (NTRS)

    Gundo, Daniel; Levit, Creon; Henze, Christopher; Sandstrom, Timothy; Ellsworth, David; Green, Bryan; Joly, Arthur

    2006-01-01

    The NASA Ames hyperwall is a display system designed to facilitate the visualization of sets of multivariate and multidimensional data like those generated in complex engineering and scientific computations. The hyperwall includes a 77 matrix of computer-driven flat-panel video display units, each presenting an image of 1,280 1,024 pixels. The term hyperwall reflects the fact that this system is a more capable successor to prior computer-driven multiple-flat-panel display systems known by names that include the generic term powerwall and the trade names PowerWall and Powerwall. Each of the 49 flat-panel displays is driven by a rack-mounted, dual-central-processing- unit, workstation-class personal computer equipped with a hig-hperformance graphical-display circuit card and with a hard-disk drive having a storage capacity of 100 GB. Each such computer is a slave node in a master/ slave computing/data-communication system (see Figure 1). The computer that acts as the master node is similar to the slave-node computers, except that it runs the master portion of the system software and is equipped with a keyboard and mouse for control by a human operator. The system utilizes commercially available master/slave software along with custom software that enables the human controller to interact simultaneously with any number of selected slave nodes. In a powerwall, a single rendering task is spread across multiple processors and then the multiple outputs are tiled into one seamless super-display. It must be noted that the hyperwall concept subsumes the powerwall concept in that a single scene could be rendered as a mosaic image on the hyperwall. However, the hyperwall offers a wider set of capabilities to serve a different purpose: The hyperwall concept is one of (1) simultaneously displaying multiple different but related images, and (2) providing means for composing and controlling such sets of images. In place of elaborate software or hardware crossbar switches, the

  11. A hierarchical two-phase framework for selecting genes in cancer datasets with a neuro-fuzzy system.

    PubMed

    Lim, Jongwoo; Wang, Bohyun; Lim, Joon S

    2016-04-29

    Finding the minimum number of appropriate biomarkers for specific targets such as a lung cancer has been a challenging issue in bioinformatics. We propose a hierarchical two-phase framework for selecting appropriate biomarkers that extracts candidate biomarkers from the cancer microarray datasets and then selects the minimum number of appropriate biomarkers from the extracted candidate biomarkers datasets with a specific neuro-fuzzy algorithm, which is called a neural network with weighted fuzzy membership function (NEWFM). In this context, as the first phase, the proposed framework is to extract candidate biomarkers by using a Bhattacharyya distance method that measures the similarity of two discrete probability distributions. Finally, the proposed framework is able to reduce the cost of finding biomarkers by not receiving medical supplements and improve the accuracy of the biomarkers in specific cancer target datasets.

  12. Hierarchical drivers of reef-fish metacommunity structure.

    PubMed

    MacNeil, M Aaron; Graham, Nicholas A J; Polunin, Nicholas V C; Kulbicki, Michel; Galzin, René; Harmelin-Vivien, Mireille; Rushton, Steven P

    2009-01-01

    Coral reefs are highly complex ecological systems, where multiple processes interact across scales in space and time to create assemblages of exceptionally high biodiversity. Despite the increasing frequency of hierarchically structured sampling programs used in coral-reef science, little progress has been made in quantifying the relative importance of processes operating across multiple scales. The vast majority of reef studies are conducted, or at least analyzed, at a single spatial scale, ignoring the implicitly hierarchical structure of the overall system in favor of small-scale experiments or large-scale observations. Here we demonstrate how alpha (mean local number of species), beta diversity (degree of species dissimilarity among local sites), and gamma diversity (overall species richness) vary with spatial scale, and using a hierarchical, information-theoretic approach, we evaluate the relative importance of site-, reef-, and atoll-level processes driving the fish metacommunity structure among 10 atolls in French Polynesia. Process-based models, representing well-established hypotheses about drivers of reef-fish community structure, were assembled into a candidate set of 12 hierarchical linear models. Variation in fish abundance, biomass, and species richness were unevenly distributed among transect, reef, and atoll levels, establishing the relative contribution of variation at these spatial scales to the structure of the metacommunity. Reef-fish biomass, species richness, and the abundance of most functional-groups corresponded primarily with transect-level habitat diversity and atoll-lagoon size, whereas detritivore and grazer abundances were largely correlated with potential covariates of larval dispersal. Our findings show that (1) within-transect and among-atoll factors primarily drive the relationship between alpha and gamma diversity in this reef-fish metacommunity; (2) habitat is the primary correlate with reef-fish metacommunity structure at

  13. Hierarchical Ensemble Methods for Protein Function Prediction

    PubMed Central

    2014-01-01

    Protein function prediction is a complex multiclass multilabel classification problem, characterized by multiple issues such as the incompleteness of the available annotations, the integration of multiple sources of high dimensional biomolecular data, the unbalance of several functional classes, and the difficulty of univocally determining negative examples. Moreover, the hierarchical relationships between functional classes that characterize both the Gene Ontology and FunCat taxonomies motivate the development of hierarchy-aware prediction methods that showed significantly better performances than hierarchical-unaware “flat” prediction methods. In this paper, we provide a comprehensive review of hierarchical methods for protein function prediction based on ensembles of learning machines. According to this general approach, a separate learning machine is trained to learn a specific functional term and then the resulting predictions are assembled in a “consensus” ensemble decision, taking into account the hierarchical relationships between classes. The main hierarchical ensemble methods proposed in the literature are discussed in the context of existing computational methods for protein function prediction, highlighting their characteristics, advantages, and limitations. Open problems of this exciting research area of computational biology are finally considered, outlining novel perspectives for future research. PMID:25937954

  14. Hierarchical Strategy for Rapid Analysis Environment

    NASA Technical Reports Server (NTRS)

    Whitcomb, John

    2003-01-01

    A new philosophy is developed wherein the hierarchical definition of data is made use of in creating a better environment to conduct analyses of practical problems. This system can be adapted to conduct virtually any type of analysis, since this philosophy is not bound to any specific kind of analysis. It provides a framework to manage different models and its results and more importantly, the interaction between the different models. Thus, it is ideal for many types of finite element analyses like globalAoca1 analysis and those that involve multiple scales and fields. The system developed during the course of this work is just a demonstrator of the basic concepts. A complete implementation of this strategy could potentially make a major impact on the way analyses are conducted. It could considerably reduce the time frame required to conduct the analysis of real-life problems by efficient management of the data involved and reducing the human effort involved. It also helps in better decision making because of more ways to interpret the results. The strategy has been currently implemented for structural analysis, but with more work it could be extended to other fields of science when the finite element method is used to solve the differential equations numerically. This report details the work that has been done during the course of this project and its achievements and results. The following section discusses the meaning of the word hierarchical and the different references to the term in the literature. It talks about the development of the finite element method, its different versions and how hierarchy has been used to improve the methodology. The next section describes the hierarchical philosophy in detail and explains the different concepts and terms associated with it. It goes on to describe the implementation and the features of the demonstrator. A couple of problems are analyzed using the demonstrator program to show the working of the system. The two

  15. Microprocessor Based Real-Time Monitoring of Multiple ECG Signals

    PubMed Central

    Nasipuri, M.; Basu, D.K.; Dattagupta, R.; Kundu, M.; Banerjee, S.

    1987-01-01

    A microprocessor based system capable of realtime monitoring of multiple ECG signals has been described. The system consists of a number of microprocessors connected in a hierarchical fashion and capable of working concurrently on ECG data collected from different channels. The system can monitor different arrhythmic abnormalities for at least 36 patients even for a heart rate of 500 beats/min.

  16. Metal halogen battery system with multiple outlet nozzle for hydrate

    DOEpatents

    Bjorkman, Jr., Harry K.

    1983-06-21

    A metal halogen battery system, including at least one cell having a positive electrode and a negative electrode contacted by aqueous electrolyte containing the material of said metal and halogen, store means whereby halogen hydrate is formed and stored as part of an aqueous material, means for circulating electrolyte through the cell and to the store means, and conduit means for transmitting halogen gas formed in the cell to a hydrate former whereby the hydrate is formed in association with the store means, said store means being constructed in the form of a container which includes a filter means, said filter means being inoperative to separate the hydrate formed from the electrolyte, said system having, a hydrate former pump means associated with the store means and being operative to intermix halogen gas with aqueous electrolyte to form halogen hydrate, said hydrate former means including, multiple outlet nozzle means connected with the outlet side of said pump means and being operative to minimize plugging, said nozzle means being comprised of at least one divider means which is generally perpendicular to the rotational axes of gears within the pump means, said divider means acting to divide the flow from the pump means into multiple outlet flow paths.

  17. Reward-related learning via multiple memory systems

    PubMed Central

    Delgado, Mauricio R.; Dickerson, Kathryn C.

    2013-01-01

    The application of a neuroeconomic approach to the study of reward-related processes has provided significant insights in our understanding of human learning and decision-making. Much of this research has primarily focused on the contributions of the cortico-striatal circuitry, involved in trial and error reward learning. As a result, less consideration has been allotted to the potential influence of different neural mechanisms such as the hippocampus, or to more common ways in human society in which information is acquired and utilized to reach a decision, such as through explicit instruction rather than trial and error learning. This review examines the basic and applied value of examining the individual contributions of multiple learning and memory neural systems and their interactions during human decision-making in normal individuals and neuropsychiatric populations. Specifically, the anatomical and functional connectivity across multiple memory systems are highlighted to suggest that probing the role of the hippocampus and its interactions with the cortico-striatal circuitry via the application of model-based neuroeconomic approaches may provide novel insights into several neuropsychiatric populations who suffer from damage to one of these structures, and as a consequence have deficits in learning, memory, or decision-making. PMID:22365667

  18. Inference and learning in sparse systems with multiple states

    SciTech Connect

    Braunstein, A.; Ramezanpour, A.; Zhang, P.; Zecchina, R.

    2011-05-15

    We discuss how inference can be performed when data are sampled from the nonergodic phase of systems with multiple attractors. We take as a model system the finite connectivity Hopfield model in the memory phase and suggest a cavity method approach to reconstruct the couplings when the data are separately sampled from few attractor states. We also show how the inference results can be converted into a learning protocol for neural networks in which patterns are presented through weak external fields. The protocol is simple and fully local, and is able to store patterns with a finite overlap with the input patterns without ever reaching a spin-glass phase where all memories are lost.

  19. The nature of the autonomic dysfunction in multiple system atrophy

    NASA Technical Reports Server (NTRS)

    Parikh, Samir M.; Diedrich, Andre; Biaggioni, Italo; Robertson, David

    2002-01-01

    The concept that multiple system atrophy (MSA, Shy-Drager syndrome) is a disorder of the autonomic nervous system is several decades old. While there has been renewed interest in the movement disorder associated with MSA, two recent consensus statements confirm the centrality of the autonomic disorder to the diagnosis. Here, we reexamine the autonomic pathophysiology in MSA. Whereas MSA is often thought of as "autonomic failure", new evidence indicates substantial persistence of functioning sympathetic and parasympathetic nerves even in clinically advanced disease. These findings help explain some of the previously poorly understood features of MSA. Recognition that MSA entails persistent, constitutive autonomic tone requires a significant revision of our concepts of its diagnosis and therapy. We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure.

  20. Simultaneous Real-Time Monitoring of Multiple Cortical Systems

    PubMed Central

    Gupta, Disha; Hill, N. Jeremy; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Schalk, Gerwin

    2014-01-01

    Objective Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor, or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach We study these questions using electrocorticographic (ECoG) signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (6 for offline parameter optimization, 6 for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelope. These decoders were trained separately and executed simultaneously in real time. Significance This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple

  1. Multiple Chaos Synchronization System for Power Quality Classification in a Power System

    PubMed Central

    Huang, Cong-Hui; Lin, Chia-Hung

    2014-01-01

    This document proposes multiple chaos synchronization (CS) systems for power quality (PQ) disturbances classification in a power system. Chen-Lee based CS systems use multiple detectors to track the dynamic errors between the normal signal and the disturbance signal, including power harmonics, voltage fluctuation phenomena, and voltage interruptions. Multiple detectors are used to monitor the dynamic errors between the master system and the slave system and are used to construct the feature patterns from time-domain signals. The maximum likelihood method (MLM), as a classifier, performs a comparison of the patterns of the features in the database. The proposed method can adapt itself without the need for adjustment of parameters or iterative computation. For a sample power system, the test results showed accurate discrimination, good robustness, and faster processing time for the detection of PQ disturbances. PMID:24764771

  2. Hierarchical Approximate Bayesian Computation

    PubMed Central

    Turner, Brandon M.; Van Zandt, Trisha

    2013-01-01

    Approximate Bayesian computation (ABC) is a powerful technique for estimating the posterior distribution of a model’s parameters. It is especially important when the model to be fit has no explicit likelihood function, which happens for computational (or simulation-based) models such as those that are popular in cognitive neuroscience and other areas in psychology. However, ABC is usually applied only to models with few parameters. Extending ABC to hierarchical models has been difficult because high-dimensional hierarchical models add computational complexity that conventional ABC cannot accommodate. In this paper we summarize some current approaches for performing hierarchical ABC and introduce a new algorithm called Gibbs ABC. This new algorithm incorporates well-known Bayesian techniques to improve the accuracy and efficiency of the ABC approach for estimation of hierarchical models. We then use the Gibbs ABC algorithm to estimate the parameters of two models of signal detection, one with and one without a tractable likelihood function. PMID:24297436

  3. Handheld camera 3D modeling system using multiple reference panels

    NASA Astrophysics Data System (ADS)

    Fujimura, Kouta; Oue, Yasuhiro; Terauchi, Tomoya; Emi, Tetsuichi

    2002-03-01

    A novel 3D modeling system in which a target object is easily captured and modeled by using a hand-held camera with several reference panels is presented in this paper. The reference panels are designed to be able to obtain the camera position and discriminate between each other. A conventional 3D modeling system using a reference panel has several restrictions regarding the target object, specifically the size and its location. Our system uses multiple reference panels, which are set around the target object to remove these restrictions. The main features of this system are as follows: 1) The whole shape and photo-realistic textures of the target object can be digitized based on several still images or a movie captured by using a hand-held camera; as well as each location of the camera that can be calculated using the reference panels. 2) Our system can be provided as a software product only. That means there are no special requirements for hardware; even the reference panels , because they can be printed from image files or software. 3) This system can be applied to digitize a larger object. In the experiments, we developed and used an interactive region selection tool to detect the silhouette on each image instead of using the chroma -keying method. We have tested our system with a toy object. The calculation time is about 10 minutes (except for the capturing the images and extracting the silhouette by using our tool) on a personal computer with a Pentium-III processor (600MHz) and 320MB memory. However, it depends on how complex the images are and how many images you use. Our future plan is to evaluate the system with various kind of objects, specifically, large ones in outdoor environments.

  4. The high multiplicity systems Gliese 667C and KOI 3158

    NASA Astrophysics Data System (ADS)

    Van Laerhoven, Christa L.; Fabrycky, D.; Greenberg, R.

    2013-10-01

    High multiplicity extra-solar systems display a wealth of planetary interactions which can constrain the orbital properties of the system as well as the physical nature of the planets (e.g, rocky vs. volatile rich). These systems may also serve as analogues for our own high-multiplicity solar system. One example is KOI 3158, a metal-poor, high-proper-motion star for which has been identified in the Kepler data set evidence for five small planets. Given the probable stellar type, K0V (Wilson 1962), we infer that the planets range in size from 0.3 to 0.5 Earth radii. The star's high proper motion and radial velocity are compatible with membership in the Milky Way's thick disk. The orbital architecture of this system includes proximity to several mean motion resonances, which allow us to constrain the mass and eccentricities of the planets. Gliese 667C, another metal poor star, hosts a system of 6 or 7 planets, 3 of which are potentially in the habitable zone. Classical secular theory of non-resonant interactions, coupled with standard tidal evolution theory, can constrain the tidal dissipation parameters Q for each of the planets. The eccentricities and pericenter longitudes from Anglada-Escude et al.’s (2013) currently-most-stable 6-planet solution (S6, their Table 6) imply that the one of the two large-amplitude secular eigenmodes is controlled by the innermost planet. Therefore, if the innermost planet's Q is < 104, going backwards in time the amplitude of this already high-amplitude mode increases, so < 2 Gyr ago (the minimum age of the star) the planets would have been too close for stability. Tides on the other planets only affect eigenmodes that are currently of low amplitude. As a result, the Qs of these planets could be very low and still be consistent with the past stability of the system. Thus, the orbital solution that is currently the most stable indicates that the inner planet cannot be rocky, while the other planets can be. In particular, the

  5. Topological properties of hierarchical networks

    NASA Astrophysics Data System (ADS)

    Agliari, Elena; Barra, Adriano; Galluzzi, Andrea; Guerra, Francesco; Tantari, Daniele; Tavani, Flavia

    2015-06-01

    Hierarchical networks are attracting a renewal interest for modeling the organization of a number of biological systems and for tackling the complexity of statistical mechanical models beyond mean-field limitations. Here we consider the Dyson hierarchical construction for ferromagnets, neural networks, and spin glasses, recently analyzed from a statistical-mechanics perspective, and we focus on the topological properties of the underlying structures. In particular, we find that such structures are weighted graphs that exhibit a high degree of clustering and of modularity, with a small spectral gap; the robustness of such features with respect to the presence of thermal noise is also studied. These outcomes are then discussed and related to the statistical-mechanics scenario in full consistency. Last, we look at these weighted graphs as Markov chains and we show that in the limit of infinite size, the emergence of ergodicity breakdown for the stochastic process mirrors the emergence of metastabilities in the corresponding statistical mechanical analysis.

  6. Incorporation of a subacute test with zebra fish into a hierarchical system for evaluating the effect of toxicants in the aquatic environment

    SciTech Connect

    Neilson, A.H.; Allard, A.S.; Fischer, S.; Malmberg, M.; Viktor, T. )

    1990-08-01

    Single-species laboratory tests were used to assess the acute toxicity of halogenated phenolic compounds. No single test system was most sensitive to all of the compounds examined, substantial variations in the sensitivity of the various organisms were noted, and there was no correlation between the toxicities assayed with different test systems. The zebra fish (Brachydanio rerio) embryo/larvae system was used to examine subacute effects using two of the compounds, and a protocol was developed with 6 weeks preexposure to the toxicant. Preexposure decreased the lowest observable effect concentration by a factor of about 4, and the effect was completely reversible during a 6-week postexposure period in the absence of the toxicant. An enclosed system for carrying out the zebra fish embryo/larvae test was developed and evaluated with three neutral volatile compounds: the median survival time and the frequency of occurrence of deformation were examined as end points. The effect of pH on toxicity was evaluated in buffered media for four of the test systems: toxicity increased markedly at the lower pH values, and it could be shown that the ionized forms of the phenols were not the only contributors to toxicity. It is proposed that the zebra fish system incorporating preexposure could be incorporated into a hierarchical system using a range of organisms for assessing acute toxicity in single species under laboratory conditions and multicomponent systems simulating natural ecosystems.

  7. Two Suns in The Sky: Stellar Multiplicity in Exoplanet Systems

    NASA Astrophysics Data System (ADS)

    Raghavan, D. R.; Henry, T. J.; Mason, B. D.; Subasavage, J. P.; Jao, W. C.; Beaulieu, T. D.; Hambly, N. C.

    2005-12-01

    We present results of a reconnaissance for stellar companions to all 131 radial-velocity-detected candidate extrasolar planetary systems known as of July 1, 2005. Common proper motion (CPM) companions were investigated using the multi-epoch STScI Digitized Sky Surveys (DSS), and confirmed by matching the trigonometric parallax distances of the primaries to companion distances estimated photometrically using SuperCOSMOS plate, CCD optical and 2MASS infrared photometry. We evaluate whether the ``companions" listed in the Washington Double Star Catalog (WDS) are gravitationally bound to the primary or coincidental alignments in the sky. We also attempt to confirm or refute companions listed in the Catalog of Nearby Stars (CNS), Hipparcos, and Duquennoy & Mayor, 1991. Our findings indicate that a lower limit of 29 (22%) of the 131 exoplanet systems have stellar companions, and an additional 7 (5%) have candidate companions. We report a previously unknown stellar companion to planet host HD 38529, and identify a companion candidate to HD 188015. We confirm 16 previously reported stellar companions to exoplanet hosts, and report 8 additional companions --- these are known stellar companions, but previously not recognized to be in exoplanet systems. In addition, we have confirmed the gravitational connection for a WDS entry for HD 222582. We have also found evidence for 20 entries in WDS that are not gravitationally bound companions --- they do not show any related proper motion in the DSS plates. At least three, and possibly five of the exoplanet systems are contained within triple star systems, and of these, HD 38529 may have a fourth stellar companion as well. Two of the exoplanet systems contain white dwarf companions. These results indicate that solar systems are found in a variety of stellar multiplicity environments -- singles, binaries, triples, and possibly quadruples; and that planets survive post-main-sequence evolution of companion stars.

  8. Using Approximate Bayesian Computation to Probe Multiple Transiting Planet Systems

    NASA Astrophysics Data System (ADS)

    Morehead, Robert C.

    2015-08-01

    The large number of multiple transiting planet systems (MTPS) uncovered with Kepler suggest a population of well-aligned planetary systems. Previously, the distribution of transit duration ratios in MTPSs has been used to place constraints on the distributions of mutual orbital inclinations and orbital eccentricities in these systems. However, degeneracies with the underlying number of planets in these systems pose added challenges and make explicit likelihood functions intractable. Approximate Bayesian computation (ABC) offers an intriguing path forward. In its simplest form, ABC proposes from a prior on the population parameters to produce synthetic datasets via a physically-motivated model. Samples are accepted or rejected based on how close they come to reproducing the actual observed dataset to some tolerance. The accepted samples then form a robust and useful approximation of the true posterior distribution of the underlying population parameters. We will demonstrate the utility of ABC in exoplanet populations by presenting new constraints on the mutual inclination and eccentricity distributions in the Kepler MTPSs. We will also introduce Simple-ABC, a new open-source Python package designed for ease of use and rapid specification of general models, suitable for use in a wide variety of applications in both exoplanet science and astrophysics as a whole.

  9. Dynamic status of the wide multiple system α Centauri + Proxima

    NASA Astrophysics Data System (ADS)

    Matvienko, A. S.; Orlov, V. V.

    2014-04-01

    We study the dynamics of a wide multiple system α Centauri + Proxima. The total energy of the system was estimated according to the available observational data on masses, coordinates, proper motions, and radial velocities of its components. To account for the effect of the observational data errors on the result, we have implemented the Monte Carlo method. From N = 106 statistical tests we show that with the probability of about 90% the motion is hyperbolic, i.e., α Cen AB and Proxima will after a while diverge from each other by a considerable distance. We also perform numerical modeling of dynamic evolution of the wide pair α Cen AB + Proxima in the regular field of the Galaxy. The trajectory of relative motion is constructed. The components diverge from each other by a distance of 20 pc over the time scale of about 200 Myr. The critical parameter for determining the dynamic status of the system is the radial velocity of the C component (Proxima), known with an error of 200 ms-1. For a reliable determination of the nature of motions in the system, we have to decrease the radial velocity error by at least an order of magnitude.

  10. Supporting Multiple Cognitive Processing Styles Using Tailored Support Systems

    SciTech Connect

    Tuan Q. Tran; Karen M. Feigh; Amy R. Pritchett

    2007-08-01

    According to theories of cognitive processing style or cognitive control mode, human performance is more effective when an individual’s cognitive state (e.g., intuition/scramble vs. deliberate/strategic) matches his/her ecological constraints or context (e.g., utilize intuition to strive for a "good-enough" response instead of deliberating for the "best" response under high time pressure). Ill-mapping between cognitive state and ecological constraints are believed to lead to degraded task performance. Consequently, incorporating support systems which are designed to specifically address multiple cognitive and functional states e.g., high workload, stress, boredom, and initiate appropriate mitigation strategies (e.g., reduce information load) is essential to reduce plant risk. Utilizing the concept of Cognitive Control Models, this paper will discuss the importance of tailoring support systems to match an operator's cognitive state, and will further discuss the importance of these ecological constraints in selecting and implementing mitigation strategies for safe and effective system performance. An example from the nuclear power plant industry illustrating how a support system might be tailored to support different cognitive states is included.

  11. Systemic Mastocytosis with Smoldering Multiple Myeloma: Report of a Case

    PubMed Central

    Garcia, Gwenalyn; Ying, Liu; Hurford, Matthew; Odaimi, Marcel

    2016-01-01

    Systemic mastocytosis (SM) is a disease characterized by a clonal infiltration of mast cells affecting various tissues of the body. It is grouped into six different subtypes according to the World Health Organization classification. It is called indolent systemic mastocytosis (ISM) when there is no evidence of end organ dysfunction, while the presence of end organ dysfunction defines aggressive systemic mastocytosis (ASM). When SM coexists with a clonal hematological disorder, it is classified as systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD). Over 80% of SM-AHNMD cases involve disorders of the myeloid cell lines. To our knowledge, there are only 8 reported cases to date of SM associated with a plasma cell disorder. We report a patient with ISM who was found to have concomitant smoldering multiple myeloma. His disease later progressed to ASM. We discuss this rare association between SM and a plasma cell disorder, and potential common pathophysiologic mechanisms linking the two disorders will be reviewed. We also discuss prognostic factors in SM as well as the management options considered during the evolution of the patient's disease. PMID:27293930

  12. Hierarchical Analysis of the Omega Ontology

    SciTech Connect

    Joslyn, Cliff A.; Paulson, Patrick R.

    2009-12-01

    Initial delivery for mathematical analysis of the Omega Ontology. We provide an analysis of the hierarchical structure of a version of the Omega Ontology currently in use within the US Government. After providing an initial statistical analysis of the distribution of all link types in the ontology, we then provide a detailed order theoretical analysis of each of the four main hierarchical links present. This order theoretical analysis includes the distribution of components and their properties, their parent/child and multiple inheritance structure, and the distribution of their vertical ranks.

  13. A genome-wide association study in multiple system atrophy

    PubMed Central

    Sailer, Anna; Nalls, Michael A.; Schulte, Claudia; Federoff, Monica; Price, T. Ryan; Lees, Andrew; Ross, Owen A.; Dickson, Dennis W.; Mok, Kin; Mencacci, Niccolo E.; Schottlaender, Lucia; Chelban, Viorica; Ling, Helen; O'Sullivan, Sean S.; Wood, Nicholas W.; Traynor, Bryan J.; Ferrucci, Luigi; Federoff, Howard J.; Mhyre, Timothy R.; Morris, Huw R.; Deuschl, Günther; Quinn, Niall; Widner, Hakan; Albanese, Alberto; Infante, Jon; Bhatia, Kailash P.; Poewe, Werner; Oertel, Wolfgang; Höglinger, Günter U.; Wüllner, Ullrich; Goldwurm, Stefano; Pellecchia, Maria Teresa; Ferreira, Joaquim; Tolosa, Eduardo; Bloem, Bastiaan R.; Rascol, Olivier; Meissner, Wassilios G.; Hardy, John A.; Revesz, Tamas; Holton, Janice L.; Gasser, Thomas; Wenning, Gregor K.; Singleton, Andrew B.

    2016-01-01

    Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. Results: We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10−6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA. Conclusions: We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps. PMID:27629089

  14. Multiple classifier system for remote sensing image classification: a review.

    PubMed

    Du, Peijun; Xia, Junshi; Zhang, Wei; Tan, Kun; Liu, Yi; Liu, Sicong

    2012-01-01

    Over the last two decades, multiple classifier system (MCS) or classifier ensemble has shown great potential to improve the accuracy and reliability of remote sensing image classification. Although there are lots of literatures covering the MCS approaches, there is a lack of a comprehensive literature review which presents an overall architecture of the basic principles and trends behind the design of remote sensing classifier ensemble. Therefore, in order to give a reference point for MCS approaches, this paper attempts to explicitly review the remote sensing implementations of MCS and proposes some modified approaches. The effectiveness of existing and improved algorithms are analyzed and evaluated by multi-source remotely sensed images, including high spatial resolution image (QuickBird), hyperspectral image (OMISII) and multi-spectral image (Landsat ETM+). Experimental results demonstrate that MCS can effectively improve the accuracy and stability of remote sensing image classification, and diversity measures play an active role for the combination of multiple classifiers. Furthermore, this survey provides a roadmap to guide future research, algorithm enhancement and facilitate knowledge accumulation of MCS in remote sensing community.

  15. Multiple Classifier System for Remote Sensing Image Classification: A Review

    PubMed Central

    Du, Peijun; Xia, Junshi; Zhang, Wei; Tan, Kun; Liu, Yi; Liu, Sicong

    2012-01-01

    Over the last two decades, multiple classifier system (MCS) or classifier ensemble has shown great potential to improve the accuracy and reliability of remote sensing image classification. Although there are lots of literatures covering the MCS approaches, there is a lack of a comprehensive literature review which presents an overall architecture of the basic principles and trends behind the design of remote sensing classifier ensemble. Therefore, in order to give a reference point for MCS approaches, this paper attempts to explicitly review the remote sensing implementations of MCS and proposes some modified approaches. The effectiveness of existing and improved algorithms are analyzed and evaluated by multi-source remotely sensed images, including high spatial resolution image (QuickBird), hyperspectral image (OMISII) and multi-spectral image (Landsat ETM+). Experimental results demonstrate that MCS can effectively improve the accuracy and stability of remote sensing image classification, and diversity measures play an active role for the combination of multiple classifiers. Furthermore, this survey provides a roadmap to guide future research, algorithm enhancement and facilitate knowledge accumulation of MCS in remote sensing community. PMID:22666057

  16. Hierarchically Structured Nanomaterials for Electrochemical Energy Conversion.

    PubMed

    Trogadas, Panagiotis; Ramani, Vijay; Strasser, Peter; Fuller, Thomas F; Coppens, Marc-Olivier

    2016-01-01

    Hierarchical nanomaterials are highly suitable as electrocatalysts and electrocatalyst supports in electrochemical energy conversion devices. The intrinsic kinetics of an electrocatalyst are associated with the nanostructure of the active phase and the support, while the overall properties are also affected by the mesostructure. Therefore, both structures need to be controlled. A comparative state-of-the-art review of catalysts and supports is provided along with detailed synthesis methods. To further improve the design of these hierarchical nanomaterials, in-depth research on the effect of materials architecture on reaction and transport kinetics is necessary. Inspiration can be derived from nature, which is full of very effective hierarchical structures. Developing fundamental understanding of how desired properties of biological systems are related to their hierarchical architecture can guide the development of novel catalytic nanomaterials and nature-inspired electrochemical devices. PMID:26549054

  17. Multiple system atrophy--the nature of the beast.

    PubMed Central

    Quinn, N

    1989-01-01

    Multiple system atrophy (MSA) is generally considered a rare disease, but may account for up to 10% of patients with Parkinsonism. The profusion of names for this disease, which may present to general physicians, psychiatrists, cardiologists, autonomic specialists, general neurologists and those with a special interest in Parkinsonism (this author's own perspective) or cerebellar disorders, together with ignorance of its protean manifestations, may account for its underrecognition and misdiagnosis. In this article, the history and nosology of the condition are considered, and provisional diagnostic criteria are advanced. The usefulness (or otherwise) of ancillary investigations is addressed, and the shortcomings of current methods of treatment are stressed. As with idiopathic Parkinson's disease, the ultimate goal of eradicating the disease entails better diagnosis in order to establish the cause, and thence to develop a radical treatment capable of preventing or arresting the disease process. PMID:2666581

  18. Multiple delivery cesium oven system for negative ion sources

    SciTech Connect

    Bansal, G.; Bhartiya, S.; Pandya, K.; Bandyopadhyay, M.; Singh, M. J.; Soni, J.; Gahlaut, A.; Parmar, K. G.; Chakraborty, A.

    2012-02-15

    Distribution of cesium in large negative ion beam sources to be operational in ITER, is presently based on the use of three or more cesium ovens, which operate simultaneously and are controlled remotely. However, use of multiple Cs ovens simultaneously is likely to pose difficulties in operation and maintenance of the ovens. An alternate method of Cs delivery, based on a single oven distribution system is proposed as one which could reduce the need of simultaneous operation of many ovens. A proof of principle experiment verifying the concept of a multinozzle distributor based Cs oven has been carried out at Institute for Plasma Research. It is also observed that the Cs flux is not controlled by Cs reservoir temperature after few hours of operation but by the temperature of the distributor which starts behaving as a Cs reservoir.

  19. Single transmission line interrogated multiple channel data acquisition system

    DOEpatents

    Fasching, George E.; Keech, Jr., Thomas W.

    1980-01-01

    A single transmission line interrogated multiple channel data acquisition system is provided in which a plurality of remote station/sensor circuits each monitors a specific process variable and each transmits measurement values over a single transmission line to a master interrogating station when addressed by said master interrogating station. Typically, as many as 330 remote stations may be parallel connected to the transmission line which may exceed 7,000 feet. The interrogation rate is typically 330 stations/second. The master interrogating station samples each station according to a shared, charging transmit-receive cycle. All remote station address signals, all data signals from the remote stations/sensors and all power for all of the remote station/sensors are transmitted via a single continuous terminated coaxial cable. A means is provided for periodically and remotely calibrating all remote sensors for zero and span. A provision is available to remotely disconnect any selected sensor station from the main transmission line.

  20. Operational effectiveness of a Multiple Aquila Control System (MACS)

    NASA Technical Reports Server (NTRS)

    Brown, R. W.; Flynn, J. D.; Frey, M. R.

    1983-01-01

    The operational effectiveness of a multiple aquila control system (MACS) was examined under a variety of remotely piloted vehicle (RPV) mission configurations. The set of assumptions and inputs used to form the rules under which a computerized simulation of MACS was run is given. The characteristics that are to govern MACS operations include: the battlefield environment that generates the requests for RPV missions, operating time-lines of the RPV-peculiar equipment, maintenance requirements, and vulnerability to enemy fire. The number of RPV missions and the number of operation days are discussed. Command, control, and communication data rates are estimated by determining how many messages are passed and what information is necessary in them to support ground coordination between MACS sections.

  1. Simultaneous multiple degrees of freedom (DoF) measurement system

    NASA Astrophysics Data System (ADS)

    Molnar, G.; Strube, S.; Köchert, P.; Danzebrink, H.-U.; Flügge, J.

    2016-08-01

    This paper presents a newly developed highly accurate interferometric 6° of freedom (DoF) measurement system with Ångström resolution for displacement and μrad resolution for angle measurement, respectively. The new interferometer is based on a modified homodyne Twyman-Green interferometer concept. It uses a novel signal acquisition and processing approach whereby a spatial interferogram is captured by a CMOS camera and the registered fringe pattern is transformed into its frequency spectrum [1]. The spectral representation of a movement of e.g. a positioning stage is analyzed for its major components: the phase information directly correlates with the displacement of the stage, while a possible rotational motion causes a shift in the frequency spectrum. The developed compact 6 DoF head uses multiple rays in parallel to detect x-y-z displacements and roll-pitch-yaw movements.

  2. Digital Image Encryption Scheme Based on Multiple Chaotic Systems

    NASA Astrophysics Data System (ADS)

    Abd El-Latif, Ahmed A.; Li, Li; Zhang, Tiejun; Wang, Ning; Song, Xianhua; Niu, Xiamu

    2012-06-01

    Image encryption is a challenging task due to the significant level of sophistication achieved by forgerers and other cybercriminals. Advanced encryption methods for secure transmission, storage, and retrieval of digital images are increasingly needed for a number of military, medical, homeland security, and other applications. In this paper, we introduce a new digital image encryption algorithm. The new algorithm employs multiple chaotic systems and cryptographic primitive operations within the encryption process, which are efficiently implemented on modern processors, and adopts round keys for encryption using a chaotic map. Experiments conducted show that the proposed algorithm possesses robust security features such as fairly uniform distribution, high sensitivity to both keys and plainimages, almost ideal entropy, and the ability to highly de-correlate adjacent pixels in the cipherimages. Furthermore, it has a large key space, which greatly increases its security for image encryption applications.

  3. Multiple automated minibioreactor system for multifunctional screening in biotechnology.

    PubMed

    Fontova, A; Soley, A; Gálvez, J; Sarró, E; Lecina, M; Rosell, J; Riu, P; Cairó, J; Gòdia, F; Bragós, R

    2006-01-01

    The current techniques applied in biotechnology allow to obtain many types of molecules that must be tested on cell cultures (high throughput screening HTS). Although such tests are usually carried out automatically on mini or microwell plates, the procedures in the preindustrial stage are performed almost manually on higher volume recipients known as bioreactors. The growth conditions in both stages are completely different. The screening system presented in this work is based on the multiwell test plates philosophy, a disposable multiple minibioreactor that allows reproduction of industrial bioreactor culture conditions: aeration, stirring, temperature, O2, pH and visible range optical absorbance measurements. It is possible to reproduce the growth conditions for both suspended and adherent animal cell types using 1 to 10 ml vol. bioreactors. In the case of bacteria or yeast, it is not possible to achieve a high biomass concentration, due to the reduced head volume air supply.

  4. Multiple system atrophy: current and future approaches to management

    PubMed Central

    Flabeau, Olivier; Meissner, Wassilios G.; Tison, François

    2010-01-01

    Multiple system atrophy (MSA) is a rare neurodegenerative disorder without any effective treatment in slowing or stopping disease progression. It is characterized by poor levodopa responsive Parkinsonism, cerebellar ataxia, pyramidal signs and autonomic failure in any combination. Current therapeutic strategies are primarily based on dopamine replacement and improvement of autonomic failure. However, symptomatic management remains disappointing and no curative treatment is yet available. Recent experimental evidence has confirmed the key role of alpha-synuclein aggregation in the pathogenesis of MSA. Referring to this hypothesis, transgenic and toxic animal models have been developed to assess candidate drugs for MSA. The standardization of diagnosis criteria and assessment procedures will allow large multicentre clinical trials to be conducted. In this article we review the available symptomatic treatment, recent results of studies investigating potential neuroprotective drugs, and future approaches for the management in MSA. PMID:21179616

  5. Simultaneous multiple degrees of freedom (DoF) measurement system

    NASA Astrophysics Data System (ADS)

    Molnar, G.; Strube, S.; Köchert, P.; Danzebrink, H.-U.; Flügge, J.

    2016-08-01

    This paper presents a newly developed highly accurate interferometric 6° of freedom (DoF) measurement system with Ångström resolution for displacement and μrad resolution for angle measurement, respectively. The new interferometer is based on a modified homodyne Twyman–Green interferometer concept. It uses a novel signal acquisition and processing approach whereby a spatial interferogram is captured by a CMOS camera and the registered fringe pattern is transformed into its frequency spectrum [1]. The spectral representation of a movement of e.g. a positioning stage is analyzed for its major components: the phase information directly correlates with the displacement of the stage, while a possible rotational motion causes a shift in the frequency spectrum. The developed compact 6 DoF head uses multiple rays in parallel to detect x–y–z displacements and roll-pitch-yaw movements.

  6. A Spectroscopic and Mineralogical Study of Multiple Asteroid Systems

    NASA Astrophysics Data System (ADS)

    Lindsay, Sean S.; Emery, J. P.; Marchis, F.; Enriquez, J.; Assafin, M.

    2013-10-01

    There are currently ~200 identified multiple asteroid systems (MASs). These systems display a large diversity in heliocentric distance, size/mass ratio, system angular momentum, mutual orbital parameters, and taxonomic class. These characteristics are simplified under the nomenclature of Descamps and Marchis (2008), which divides MASs into four types: Type-1 - large asteroids with small satellites; Type-2 - similar size double asteroids; Type-3 - small asynchronous systems; and Type-4 - contact-binary asteroids. The large MAS diversity suggests multiple formation mechanisms are required to understand their origins. There are currently three broad formation scenarios: 1) ejecta from impacts; 2) catastrophic disruption followed by rotational fission; and 3) tidal disruption. The taxonomic class and mineralogy of the MASs coupled with the average density and system angular momentum provide a potential means to discriminate between proposed formation mechanisms. We present visible and near-infrared (NIR) spectra spanning 0.45 - 2.45 μm for 23 Main Belt MASs. The data were primarily obtained using the Southern Astrophysical Research Telescope (SOAR) Goodman High Throughput Spectrograph (August 2011 - July 2012) for the visible data and the InfraRed Telescope Facility (IRTF) SpeX Spectrograph (August 2008 - May 2013) for the IR data. Our data were supplemented using previously published data when necessary. The asteroids' Bus-DeMeo taxonomic classes are determined using the MIT SMASS online classification routines. Our sample includes 3 C-types, 1 X-type, 1 K-type, 1 L-type, 4 V-types, 10 S-types, 2 Sq- or Q-types, and 1 ambiguous classification. We calculate the 1- and 2-μm band centers, depths, and areas to determine the pyroxene mineralogy (molar Fs and Wo) of the surfaces using empirically derived equations. The NIR band analysis allows us to determine the S-type subclasses, S(I) - S(VII), which roughly tracks olivine-pyroxene chemistry. A comparison of the orbital

  7. Design of a wavelength frame multiplication system using acceptance diagrams

    NASA Astrophysics Data System (ADS)

    Nekrassov, D.; Zendler, C.; Lieutenant, K.

    2013-07-01

    The concept of Wavelength Frame Multiplication (WFM) was developed to extend the usable wavelength range on long pulse neutron sources for instruments using pulse shaping choppers. For some instruments, it is combined with a pulse shaping double chopper, which defines a constant wavelength resolution, and a set of frame overlap choppers that prevent spurious neutrons from reaching the detector thus avoiding systematic errors in the calculation of wavelength from time of flight. Due to its complexity, the design of such a system is challenging and there are several criteria that need to be accounted for. In this work, the design of the WFM chopper system for a potential future liquids reflectometer at the European Spallation Source (ESS) is presented, which makes use of acceptance diagrams. They prove to be a powerful tool for understanding the work principle of the system and recognizing potential problems. The authors assume that the presented study can be useful for design or upgrade of further instruments, in particular the ones planned for the ESS.

  8. Resonant transmission through a multiple periodic scattering system

    NASA Astrophysics Data System (ADS)

    Okita, Taishi; Tanaka, Hiroya

    2012-08-01

    We investigate the propagation and transmission of electromagnetic (EM) waves in the subwavelength regime when a multiple periodic scattering system (MPSS) is illuminated by a monochromatic plane wave. This system has a cascaded structure with square hole arrays periodically perforated on a metal slab with arbitrary slab thickness and arbitrary air-gap. The framework of this paper is based on a modal expansion theory, in which the EM fields in pure vacuum are expanded in terms of plane waves, while those in the holes of the slab are expressed in terms of waveguide modes. The boundary conditions for the EM waves lead to a system of equations whose solution can be obtained quasianalytically in a monomodal approximation method. We study the transmission spectrum and field distribution in the MPSS, varying geometrical parameters such as the air-gap and/or number N of slabs in the context of symmetrical and asymmetrical geometries. We find that an MPSS with N ≥ 2 provides discrete transmission windows whose resonance order linearly increases against N and the associated resonance wavelengths are confined to a specific finite band for large N. The EM fields at the resonance states are quite uniquely distributed in the MPSS, depending not only on the resonance wavelength, but also either on even N or on odd N. We also demonstrate that the transmission of the EM energy is strongly boosted by the evanescent electric fields mirror-symmetrically distributed in the air-gaps of the MPSS.

  9. A Multiple-Channel Sub-Band Transient Detection System

    SciTech Connect

    David A. Smith

    1998-11-01

    We have developed a unique multiple-channel sub-band transient detection system to record transient electromagnetic signals in carrier-dominated radio environments; the system has been used to make unique observations of weak, transient HF signals. The detection system has made these observations possible through improved sensitivity compared to conventional broadband transient detection systems; the sensitivity improvement is estimated to be at least 20 dB. The increase in sensitivity has been achieved through subdivision of the band of interest (an 18 MHz tunable bandwidth) into eight sub-band independent detection channels, each with a 400 kHz bandwidth and its own criteria. The system generates a system trigger signal when a predetermined number of channels (typically five) trigger within a predetermined window of time (typically 100 ~s). Events are recorded with a broadband data acquisition system sampling at 50 or 100 Msample/s, so despite the fact that the detection system operates on portions of the signal confined to narrow bands, data acquisition is broadband. Between May and September of 1994, the system was used to detect and record over six thousand transient events in the frequency band from 3 to 30 MHz. Approximately 500 of the events have been characterized as paired bursts of radio noise with individual durations of 2 to 10 ps and separations between the bursts of 5 to 160 ps. The paired transients are typically 5 to 40 dB brighter than the background electromagnetic spectrum between carrier signals. We have termed these events SubIonospheric Pulse Pairs (SIPPS) and presently have no explanation as to their source. Our observations of SIPPS resemble observations of TransIonospheric Pulse Pairs (TIPPs) recorded by the Blackboard instrument on the ALEXIS satellite; the source of TIPP events is also unknown. Most of the recorded SIPP events do not exhibit frequency dispersion, implying propagation along a line-of-sight (groundwave) path; but seven of

  10. Music recommendation system for biofied building considering multiple residents

    NASA Astrophysics Data System (ADS)

    Ito, Takahiro; Mita, Akira

    2012-04-01

    This research presents a music recommendation system based on multiple users' communication excitement and productivity. Evaluation is conducted on following two points. 1, Does songA recommended by the system improve the situation of dropped down communication excitement? 2, Does songB recommended by the system improve the situation of dropped down and productivity of collaborative work? The objective of this system is to recommend songs which shall improve the situation of dropped down communication excitement and productivity. Songs are characterized according to three aspects; familiarity, relaxing and BPM(Beat Per Minutes). Communication excitement is calculated from speech data obtained by an audio sensor. Productivity of collaborative brainstorming is manually calculated by the number of time-series key words during mind mapping. First experiment was music impression experiment to 118 students. Based on 1, average points of familiarity, relaxing and BPM 2, cronbach alpha factor, songA(high familiarity, high relaxing and high BPM song) and songB(high familiarity, high relaxing and low BPM) are selected. Exploratory experiment defined dropped down communication excitement and dropped down and productivity of collaborative work. Final experiment was conducted to 32 first meeting students divided into 8 groups. First 4 groups had mind mapping 1 while listening to songA, then had mind mapping 2 while listening songB. Following 4 groups had mind mapping 1 while listening to songB, then had mind mapping 2 while listening songA. Fianl experiment shows two results. Firstly, ratio of communication excitement between music listening section and whole brain storming is 1.27. Secondly, this system increases 69% of average productivity.

  11. Statistical label fusion with hierarchical performance models

    PubMed Central

    Asman, Andrew J.; Dagley, Alexander S.; Landman, Bennett A.

    2014-01-01

    Label fusion is a critical step in many image segmentation frameworks (e.g., multi-atlas segmentation) as it provides a mechanism for generalizing a collection of labeled examples into a single estimate of the underlying segmentation. In the multi-label case, typical label fusion algorithms treat all labels equally – fully neglecting the known, yet complex, anatomical relationships exhibited in the data. To address this problem, we propose a generalized statistical fusion framework using hierarchical models of rater performance. Building on the seminal work in statistical fusion, we reformulate the traditional rater performance model from a multi-tiered hierarchical perspective. This new approach provides a natural framework for leveraging known anatomical relationships and accurately modeling the types of errors that raters (or atlases) make within a hierarchically consistent formulation. Herein, we describe several contributions. First, we derive a theoretical advancement to the statistical fusion framework that enables the simultaneous estimation of multiple (hierarchical) performance models within the statistical fusion context. Second, we demonstrate that the proposed hierarchical formulation is highly amenable to the state-of-the-art advancements that have been made to the statistical fusion framework. Lastly, in an empirical whole-brain segmentation task we demonstrate substantial qualitative and significant quantitative improvement in overall segmentation accuracy. PMID:24817809

  12. Rotating dipole and quadrupole field for a multiple cathode system

    SciTech Connect

    Chang, X.; Ben-Zvi, I.; Kewisch, J.; Litvinenko, V.; Meng, W.; Pikin, A.; Ptitsyn, V.; Rao, T.; Sheehy, B.; Skarita, J.; Wang, E.; Wu, Q.; Xin, T.

    2011-03-28

    A multiple cathode system has been designed to provide the high average current polarized electron bunches for the future electron-ion collider eRHIC [1]. One of the key research topics in this design is the technique to generate a combined dipole and quadrupole rotating field at high frequency (700 kHz). This type of field is necessary for combining bunches from different cathodes to the same axis with minimum emittance growth. Our simulations and the prototype test results to achieve this will be presented. The future eRHIC project, next upgrade of EHIC, will be the first electron-heavy ion collider in the world. For polarized-electron and polarized proton collisions, it requires a polarized electron source with high average current ({approx}50 mA), short bunch ({approx}3 mm), emittance of about 20 {micro}m and energy spread of {approx}1% at 10 MeV. The state-of-art polarized electron cathode can generate average current of about more than 1 mA, but much less than 50 mA. The current is limited by the quantum efficiency, lifetime, space charge and ultra-high vacuum requirement of the polarized cathode. A possible approach to achieve the 50 mA beam is to employ multiple cathodes, such as 20 cathodes, and combine the multiple bunched beams from cathodes to the same axis. We name it as 'Gatling gun' because its operations bear similarity to a multi-barrel Gatling gun. The electron spin direction is not affected by electric field but will follow to the direction of the magnetic bending. This requires that, to preserve the spin polarization from cathode, the fixed bending field after the solenoid and the rotating bending field in combiner must be either a pair of electric bendings or a pair of magnetic bendings. We choose the scheme with a pair of magnetic bendings because it is much easier than the scheme with a pair of electric bendings at our 200 keV electron energy level.

  13. Fractal image perception provides novel insights into hierarchical cognition.

    PubMed

    Martins, M J; Fischmeister, F P; Puig-Waldmüller, E; Oh, J; Geissler, A; Robinson, S; Fitch, W T; Beisteiner, R

    2014-08-01

    Hierarchical structures play a central role in many aspects of human cognition, prominently including both language and music. In this study we addressed hierarchy in the visual domain, using a novel paradigm based on fractal images. Fractals are self-similar patterns generated by repeating the same simple rule at multiple hierarchical levels. Our hypothesis was that the brain uses different resources for processing hierarchies depending on whether it applies a "fractal" or a "non-fractal" cognitive strategy. We analyzed the neural circuits activated by these complex hierarchical patterns in an event-related fMRI study of 40 healthy subjects. Brain activation was compared across three different tasks: a similarity task, and two hierarchical tasks in which subjects were asked to recognize the repetition of a rule operating transformations either within an existing hierarchical level, or generating new hierarchical levels. Similar hierarchical images were generated by both rules and target images were identical. We found that when processing visual hierarchies, engagement in both hierarchical tasks activated the visual dorsal stream (occipito-parietal cortex, intraparietal sulcus and dorsolateral prefrontal cortex). In addition, the level-generating task specifically activated circuits related to the integration of spatial and categorical information, and with the integration of items in contexts (posterior cingulate cortex, retrosplenial cortex, and medial, ventral and anterior regions of temporal cortex). These findings provide interesting new clues about the cognitive mechanisms involved in the generation of new hierarchical levels as required for fractals.

  14. A Putative Multiple-Demand System in the Macaque Brain

    PubMed Central

    Bell, Andrew H.; Buckley, Mark J.; Mitchell, Anna S.; Sallet, Jerome; Duncan, John

    2016-01-01

    In humans, cognitively demanding tasks of many types recruit common frontoparietal brain areas. Pervasive activation of this “multiple-demand” (MD) network suggests a core function in supporting goal-oriented behavior. A similar network might therefore be predicted in nonhuman primates that readily perform similar tasks after training. However, an MD network in nonhuman primates has not been described. Single-cell recordings from macaque frontal and parietal cortex show some similar properties to human MD fMRI responses (e.g., adaptive coding of task-relevant information). Invasive recordings, however, come from limited prespecified locations, so they do not delineate a macaque homolog of the MD system and their positioning could benefit from knowledge of where MD foci lie. Challenges of scanning behaving animals mean that few macaque fMRI studies specifically contrast levels of cognitive demand, so we sought to identify a macaque counterpart to the human MD system using fMRI connectivity in 35 rhesus macaques. Putative macaque MD regions, mapped from frontoparietal MD regions defined in humans, were found to be functionally connected under anesthesia. To further refine these regions, an iterative process was used to maximize their connectivity cross-validated across animals. Finally, whole-brain connectivity analyses identified voxels that were robustly connected to MD regions, revealing seven clusters across frontoparietal and insular cortex comparable to human MD regions and one unexpected cluster in the lateral fissure. The proposed macaque MD regions can be used to guide future electrophysiological investigation of MD neural coding and in task-based fMRI to test predictions of similar functional properties to human MD cortex. SIGNIFICANCE STATEMENT In humans, a frontoparietal “multiple-demand” (MD) brain network is recruited during a wide range of cognitively demanding tasks. Because this suggests a fundamental function, one might expect a similar

  15. Multiple System Atrophy. Using Clinical Pharmacology to Reveal Pathophysiology

    PubMed Central

    Jordan, Jens; Shibao, Cyndya; Biaggioni, Italo

    2015-01-01

    Despite similarities in their clinical presentation, patients with multiple system atrophy (MSA) have residual sympathetic tone and intact post-ganglionic noradrenergic fibers, whereas patients with pure autonomic failure (PAF) and Parkinson’s disease (PD) have efferent post-ganglionic autonomic denervation. These differences are apparent biochemically, with near normal plasma norepinephrine in MSA but very low levels in PAF, and in neurophysiological testing. These differences are also reflected in the response patients have to drugs that interact with the autonomic nervous system. E.g., the ganglionic blocker trimethaphan reduce residual sympathetic tone and lower blood pressure in MSA but less so in PAF. Conversely, the α2-antagonist yohimbine produces a greater increase in blood pressure in MSA compared to PAF, although significant overlap exists. In normal subjects the norepinephrine reuptake (NET) inhibitor atomoxetine has little effect on blood pressure because the peripheral effects of NET inhibition that result in noradrenergic vasoconstriction, are counteracted by the increase in brain norepinephrine which reduces sympathetic outflow (a clonidine-like effect). In patients with autonomic failure and intact peripheral noradrenergic fibers only the peripheral vasoconstriction is apparent. This translates to a significant pressor effect of atomoxetine in MSA, but not in PAF patients. Thus, pharmacological probes can be used to understand the pathophysiology of the different forms of autonomic failure, assist in the diagnosis, and aid in the management of orthostatic hypotension. PMID:25757803

  16. Design of a Multiple Drug Delivery System Directed at Periodontitis

    PubMed Central

    Sundararaj, Sharath C.; Thomas, Mark V.; Peyyala, Rebecca; Dziubla, Thomas D.; Puleo, David A.

    2013-01-01

    Periodontal disease is highly prevalent, with 90% of the world population affected by either periodontitis or its preceding condition, gingivitis. These conditions are caused by bacterial biofilms on teeth, which stimulate a chronic inflammatory response that leads to loss of alveolar bone and, ultimately, the tooth. Current treatment methods for periodontitis address specific parts of the disease, with no individual treatment serving as a complete therapy. The present research sought to demonstrate development of a multiple drug delivery system for stepwise treatment of different stages of periodontal disease. More specifically, multilayered films were fabricated from an association polymer comprising cellulose acetate phthalate and Pluronic F-127 to achieve sequential release of drugs. The four types of drugs used were metronidazole, ketoprofen, doxycycline, and simvastatin to eliminate infection, inhibit inflammation, prevent tissue destruction, and aid bone regeneration, respectively. Different erosion times and adjustable sequential release profiles were achieved by modifying the number of layers or by inclusion of a slower-eroding polymer layer. Analysis of antibiotic and anti-inflammatory bioactivity showed that drugs released from the devices retained 100% bioactivity. The multilayered CAPP delivery system offers a versatile approach for releasing different drugs based on the pathogenesis of periodontitis and other conditions. PMID:23948165

  17. The Influence of Number of A Trials on 2-Year-Olds' Behavior in Two A-Not-B-Type Search Tasks: A Test of the Hierarchical Competing Systems Model

    ERIC Educational Resources Information Center

    Marcovitch, Stuart; Zelazo, Philip David

    2006-01-01

    Age-appropriate modifications of the A-not-B task were used to examine 2-year-olds' search behavior. Several theories predict that A-not-B errors will increase as a function of number of A trials. However, the hierarchical competing systems model (Marcovitch & Zelazo, 1999) predicts that although the ratio of perseverative to nonperseverative…

  18. Designing an Electronic Patient Management System for Multiple Sclerosis: Building a Next Generation Multiple Sclerosis Documentation System

    PubMed Central

    Kern, Raimar; Haase, Rocco; Eisele, Judith Christina; Thomas, Katja

    2016-01-01

    Background Technologies like electronic health records or telemedicine devices support the rapid mediation of health information and clinical data independent of time and location between patients and their physicians as well as among health care professionals. Today, every part of the treatment process from diagnosis, treatment selection, and application to patient education and long-term care may be enhanced by a quality-assured implementation of health information technology (HIT) that also takes data security standards and concerns into account. In order to increase the level of effectively realized benefits of eHealth services, a user-driven needs assessment should ensure the inclusion of health care professional perspectives into the process of technology development as we did in the development process of the Multiple Sclerosis Documentation System 3D. After analyzing the use of information technology by patients suffering from multiple sclerosis, we focused on the needs of neurological health care professionals and their handling of health information technology. Objective Therefore, we researched the status quo of eHealth adoption in neurological practices and clinics as well as health care professional opinions about potential benefits and requirements of eHealth services in the field of multiple sclerosis. Methods We conducted a paper-and-pencil–based mail survey in 2013 by sending our questionnaire to 600 randomly chosen neurological practices in Germany. The questionnaire consisted of 24 items covering characteristics of participating neurological practices (4 items), the current use of network technology and the Internet in such neurological practices (5 items), physicians’ attitudes toward the general and MS-related usefulness of eHealth systems (8 items) and toward the clinical documentation via electronic health records (4 items), and physicians’ knowledge about the Multiple Sclerosis Documentation System (3 items). Results From 600 mailed

  19. Multiple mean motion resonances in the HR 8799 planetary system

    NASA Astrophysics Data System (ADS)

    Goździewski, Krzysztof; Migaszewski, Cezary

    2014-06-01

    HR 8799 is a nearby star hosting at least four ˜10 mJup planets in wide orbits up to ˜70 au, detected through the direct, high-contrast infrared imaging. Large companions and debris discs reported interior to ˜10 au, and exterior to ˜100 au indicate massive protoplanetary disc in the past. The dynamical state of the HR 8799 system is not yet fully resolved, due to limited astrometric data covering tiny orbital arcs. We construct a new orbital model of the HR 8799 system, assuming rapid migration of the planets after their formation in wider orbits. We found that the HR 8799 planets are likely involved in double Laplace resonance, 1e:2d:4c:8b MMR. Quasi-circular planetary orbits are coplanar with the stellar equator and inclined by ˜25° to the sky plane. This best-fitting orbital configuration matches astrometry, debris disc models, and mass estimates from cooling models. The multiple mean motion resonance (MMR) is stable for the age of the star ˜160 Myr, for at least 1 Gyr unless significant perturbations to the N-body dynamics are present. We predict four configurations with the fifth hypothetical innermost planet HR 8799f in ˜9.7 au, or ˜7.5 au orbit, extending the MMR chain to triple Laplace resonance 1f:2e:4d:8c:16b MMR or to the 1f:3e:6d:12c:24b MMR, respectively. Our findings may establish strong boundary conditions for the system formation and its early history.

  20. Identification of limit cycles in multi-nonlinearity, multiple path systems

    NASA Technical Reports Server (NTRS)

    Mitchell, J. R.; Barron, O. L.

    1979-01-01

    A method of analysis which identifies limit cycles in autonomous systems with multiple nonlinearities and multiple forward paths is presented. The FORTRAN code for implementing the Harmonic Balance Algorithm is reported. The FORTRAN code is used to identify limit cycles in multiple path and nonlinearity systems while retaining the effects of several harmonic components.

  1. Interest rates hierarchical structure

    NASA Astrophysics Data System (ADS)

    Di Matteo, T.; Aste, T.; Hyde, S. T.; Ramsden, S.

    2005-09-01

    We propose a general method to study the hierarchical organization of financial data by embedding the structure of their correlations in metric graphs in multi-dimensional spaces. An application to two different sets of interest rates is discussed by constructing triangular embeddings on the sphere. Three-dimensional representations of these embeddings with the correct metric geometry are constructed and visualized. The resulting graphs contain the minimum spanning tree as a sub-graph and they preserve its hierarchical structure. This produces a clear cluster differentiation and allows us to compute new local and global topological quantities.

  2. Blind decorrelation and deconvolution algorithm for multiple-input multiple-output system: II. Analysis and simulation

    NASA Astrophysics Data System (ADS)

    Chen, Da-Ching; Yu, Tommy; Yao, Kung; Pottie, Gregory J.

    1999-11-01

    For single-input multiple-output (SIMO) systems blind deconvolution based on second-order statistics has been shown promising given that the sources and channels meet certain assumptions. In our previous paper we extend the work to multiple-input multiple-output (MIMO) systems by introducing a blind deconvolution algorithm to remove all channel dispersion followed by a blind decorrelation algorithm to separate different sources from their instantaneous mixture. In this paper we first explore more details embedded in our algorithm. Then we present simulation results to show that our algorithm is applicable to MIMO systems excited by a broad class of signals such as speech, music and digitally modulated symbols.

  3. Kinematics and dynamics of robotic systems with multiple closed loops

    NASA Astrophysics Data System (ADS)

    Zhang, Chang-De

    The kinematics and dynamics of robotic systems with multiple closed loops, such as Stewart platforms, walking machines, and hybrid manipulators, are studied. In the study of kinematics, focus is on the closed-form solutions of the forward position analysis of different parallel systems. A closed-form solution means that the solution is expressed as a polynomial in one variable. If the order of the polynomial is less than or equal to four, the solution has analytical closed-form. First, the conditions of obtaining analytical closed-form solutions are studied. For a Stewart platform, the condition is found to be that one rotational degree of freedom of the output link is decoupled from the other five. Based on this condition, a class of Stewart platforms which has analytical closed-form solution is formulated. Conditions of analytical closed-form solution for other parallel systems are also studied. Closed-form solutions of forward kinematics for walking machines and multi-fingered grippers are then studied. For a parallel system with three three-degree-of-freedom subchains, there are 84 possible ways to select six independent joints among nine joints. These 84 ways can be classified into three categories: Category 3:3:0, Category 3:2:1, and Category 2:2:2. It is shown that the first category has no solutions; the solutions of the second category have analytical closed-form; and the solutions of the last category are higher order polynomials. The study is then extended to a nearly general Stewart platform. The solution is a 20th order polynomial and the Stewart platform has a maximum of 40 possible configurations. Also, the study is extended to a new class of hybrid manipulators which consists of two serially connected parallel mechanisms. In the study of dynamics, a computationally efficient method for inverse dynamics of manipulators based on the virtual work principle is developed. Although this method is comparable with the recursive Newton-Euler method for

  4. Hierarchical Model Validation of Symbolic Performance Models of Scientific Kernels

    SciTech Connect

    Alam, Sadaf R; Vetter, Jeffrey S

    2006-08-01

    Multi-resolution validation of hierarchical performance models of scientific applications is critical primarily for two reasons. First, the step-by-step validation determines the correctness of all essential components or phases in a science simulation. Second, a model that is validated at multiple resolution levels is the very first step to generate predictive performance models, for not only existing systems but also for emerging systems and future problem sizes. We present the design and validation of hierarchical performance models of two scientific benchmarks using a new technique called the modeling assertions (MA). Our MA prototype framework generates symbolic performance models that can be evaluated efficiently by generating the equivalent model representations in Octave and MATLAB. The multi-resolution modeling and validation is conducted on two contemporary, massively-parallel systems, XT3 and Blue Gene/L system. The workload distribution and the growth rates predictions generated by the MA models are confirmed by the experimental data collected on the MPP platforms. In addition, the physical memory requirements that are generated by the MA models are verified by the runtime values on the Blue Gene/L system, which has 512 MBytes and 256 MBytes physical memory capacity in its two unique execution modes.

  5. Retinal thinning correlates with clinical severity in multiple system atrophy.

    PubMed

    Ahn, Jeeyun; Lee, Jee-Young; Kim, Tae Wan

    2016-10-01

    To analyze retinal thickness changes in multiple system atrophy (MSA) and correlate changes with disease severity and subtypes of MSA. A total of 36 MSA (27 MSA-P and 9 MSA-C) patients and 71 healthy control subjects underwent general ophthalmologic examination and optical coherence tomography (OCT) scans. Peripapillary retinal nerve fiber layer (RNFL) thickness and perifoveal retinal thickness were analyzed separately. The generalized estimating equation model was used with age as a covariate to adjust for within-patient inter-eye correlations and the effect of age on retinal or RNFL thickness. Correlation analysis between RNFL, perifoveal thickness, and clinical parameters, the Unified MSA Rating Scale (UMSARS) and Global Disability Score (GDS), was also done. MSA patients showed significantly decreased peripapillary RNFL thickness in the inferior (P = 0.047) and inferotemporal (P = 0.017) sectors and significant perifoveal thinning in the superior outer sector (P = 0.042) compared to healthy controls. Both RNFL and perifoveal thinning were more marked and widespread in MSA-P than MSA-C patients. The UMSARS and GDS showed significant negative correlation with center and total macular perifoveal thickness and also the inferior and nasal outer sectors. Peripapillary RNFL and perifoveal retinal thinning were observed in MSA patients and retinal thinning correlated with the clinical severity of MSA. Structural changes in the retina may reflect the degree and pattern of neurodegeneration occurring in MSA.

  6. [Mechanism of neuronal degeneration of multiple system atrophy].

    PubMed

    Yoshida, Mari; Sone, Mie

    2009-09-01

    Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that encompasses olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy-Drager syndrome (SDS). The histopathological hallmarks are alpha-synuclein (AS) positive glial cytoplasmic inclusions (GCIs) in oligodendroglias. AS aggregation is also found in glial nuclear inclusions (GNIs), neuronal cytoplasmic inclusions (NCIs), neuronal nuclear inclusions (NNIs) and dystrophic neurites. Reviewing the pathological features in 102 MSA cases revealed that the, OPCA-type was relatively more frequent and SND-type was less frequent in Japanese MSA cases. The frequency of the SND-type is relatively high in Western countries. This different in the dominant type suggests that the phenotypic patterns of MSA may vary with the race. In early stages of MSA, in addition to GCIs, NNIs, NCIs, and diffuse homogenous stain of AS in neuronal nuclei and cytoplasm were observed in various vulnerable lesions including the pontine nuclei, putamen, substantia nigra, locus ceruleus, inferior olivary nucleus, intermediolateral column of the thoracic cord, lower motor neurons, and cortical pyramidal neurons. These findings indicated that the primary nonfibrillar and fibrillar AS aggregation also occurred in neurons. Therefore, both the direct involvement of neurons themselves and the oligodendroglia-myelin-axon mechanism may synergistically accelerate the degenerative process of MSA. PMID:19803404

  7. Lorentz symmetric n-particle systems without ``multiple times''

    NASA Astrophysics Data System (ADS)

    Smith, Felix

    2013-05-01

    The need for multiple times in relativistic n-particle dynamics is a consequence of Minkowski's postulated symmetry between space and time coordinates in a space-time s = [x1 , . . ,x4 ] = [ x , y , z , ict ] , Eq. (1). Poincaré doubted the need for this space-time symmetry, believing Lorentz covariance could also prevail in some geometries with a three-dimensional position space and a quite different time coordinate. The Hubble expansion observed later justifies a specific geometry of this kind, a negatively curved position 3-space expanding with time at the Hubble rate lH (t) =lH , 0 + cΔt (F. T. Smith, Ann. Fond. L. de Broglie, 30, 179 (2005) and 35, 395 (2010)). Its position 4-vector is not s but q = [x1 , . . ,x4 ] = [ x , y , z , ilH (t) ] , and shows no 4-space symmetry. What is observed is always a difference 4-vector Δq = [ Δx , Δy , Δz , icΔt ] , and this displays the structure of Eq. (1) perfectly. Thus we find the standard 4-vector of special relativity in a geometry that does not require a Minkowski space-time at all, but a quite different geometry with a expanding 3-space symmetry and an independent time. The same Lorentz symmetry with but a single time extends to 2 and n-body systems.

  8. Neural Computations in a Dynamical System with Multiple Time Scales.

    PubMed

    Mi, Yuanyuan; Lin, Xiaohan; Wu, Si

    2016-01-01

    Neural systems display rich short-term dynamics at various levels, e.g., spike-frequency adaptation (SFA) at the single-neuron level, and short-term facilitation (STF) and depression (STD) at the synapse level. These dynamical features typically cover a broad range of time scales and exhibit large diversity in different brain regions. It remains unclear what is the computational benefit for the brain to have such variability in short-term dynamics. In this study, we propose that the brain can exploit such dynamical features to implement multiple seemingly contradictory computations in a single neural circuit. To demonstrate this idea, we use continuous attractor neural network (CANN) as a working model and include STF, SFA and STD with increasing time constants in its dynamics. Three computational tasks are considered, which are persistent activity, adaptation, and anticipative tracking. These tasks require conflicting neural mechanisms, and hence cannot be implemented by a single dynamical feature or any combination with similar time constants. However, with properly coordinated STF, SFA and STD, we show that the network is able to implement the three computational tasks concurrently. We hope this study will shed light on the understanding of how the brain orchestrates its rich dynamics at various levels to realize diverse cognitive functions. PMID:27679569

  9. Diffusion tensor imaging in the characterization of multiple system atrophy

    PubMed Central

    Rulseh, Aaron Michael; Keller, Jiri; Rusz, Jan; Syka, Michael; Brozova, Hana; Rusina, Robert; Havrankova, Petra; Zarubova, Katerina; Malikova, Hana; Jech, Robert; Vymazal, Josef

    2016-01-01

    Purpose Multiple system atrophy (MSA) is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI). Materials and methods Twenty MSA subjects, ten parkinsonian dominant (MSA-P), ten cerebellar dominant (MSA-C), and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values. Results We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA-P subgroups. Altered DTI metrics in the putamen and middle cerebellar peduncles were associated with a positive parkinsonian and cerebellar phenotype, respectively. Concerning clinical applicability, we achieved high classification performance on mean diffusivity data in the combined bilateral putamen and middle cerebellar peduncle (accuracy 90.3%±9%, sensitivity 86.5%±11%, and specificity 99.3%±4%). Conclusion DTI in the middle cerebellar peduncle and putamen may be used in the diagnosis of MSA with a high degree of accuracy.

  10. Therapeutic advances in multiple system atrophy and progressive supranuclear palsy.

    PubMed

    Poewe, Werner; Mahlknecht, Philipp; Krismer, Florian

    2015-09-15

    Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are relentlessly progressive neurodegenerative diseases leading to severe disability and ultimately death within less than 10 y. Despite increasing efforts in basic and clinical research, effective therapies for these atypical parkinsonian disorders are lacking. Although earlier small clinical studies in MSA and PSP mainly focused on symptomatic treatment, advances in the understanding of the molecular underpinnings of these diseases and in the search for biomarkers have paved the way for the first large and well-designed clinical trials aiming at disease modification. Targets of intervention in these trials have included α-synuclein inclusion pathology in the case of MSA and tau-related mechanisms in PSP. Since 2013, four large randomized, placebo-controlled, double-blind disease-modification trials have been completed and published, using rasagiline (MSA), rifampicin (MSA), tideglusib (PSP), or davunetide (PSP). All of these failed to demonstrate signal efficacy with regard to the primary outcome measures. In addition, two randomized, placebo-controlled, double-blind trials have studied the efficacy of droxidopa in the symptomatic treatment of neurogenic orthostatic hypotension, including patients with MSA, with positive results in one trial. This review summarizes the design and the outcomes of these and other smaller trials published since 2013 and attempts to highlight priority areas of future therapeutic research in MSA and PSP. © 2015 International Parkinson and Movement Disorder Society.

  11. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum.

    PubMed

    Barca, Emanuele; Kleiner, Giulio; Tang, Guomei; Ziosi, Marcello; Tadesse, Saba; Masliah, Eliezer; Louis, Elan D; Faust, Phyllis; Kang, Un J; Torres, Jose; Cortes, Etty P; Vonsattel, Jean-Paul G; Kuo, Sheng-Han; Quinzii, Catarina M

    2016-07-01

    In familial and sporadic multiple system atrophy (MSA) patients, deficiency of coenzyme Q10 (CoQ10) has been associated with mutations in COQ2, which encodes the second enzyme in the CoQ10 biosynthetic pathway. Cerebellar ataxia is the most common presentation of CoQ10 deficiency, suggesting that the cerebellum might be selectively vulnerable to low levels of CoQ10 To investigate whether CoQ10 deficiency represents a common feature in the brains of MSA patients independent of the presence of COQ2 mutations, we studied CoQ10 levels in postmortem brains of 12 MSA, 9 Parkinson disease (PD), 9 essential tremor (ET) patients, and 12 controls. We also assessed mitochondrial respiratory chain enzyme activities, oxidative stress, mitochondrial mass, and levels of enzymes involved in CoQ biosynthesis. Our studies revealed CoQ10 deficiency in MSA cerebellum, which was associated with impaired CoQ biosynthesis and increased oxidative stress in the absence of COQ2 mutations. The levels of CoQ10 in the cerebella of ET and PD patients were comparable or higher than in controls. These findings suggest that CoQ10 deficiency may contribute to the pathogenesis of MSA. Because no disease modifying therapies are currently available, increasing CoQ10 levels by supplementation or upregulation of its biosynthesis may represent a novel treatment strategy for MSA patients.

  12. Neural Computations in a Dynamical System with Multiple Time Scales

    PubMed Central

    Mi, Yuanyuan; Lin, Xiaohan; Wu, Si

    2016-01-01

    Neural systems display rich short-term dynamics at various levels, e.g., spike-frequency adaptation (SFA) at the single-neuron level, and short-term facilitation (STF) and depression (STD) at the synapse level. These dynamical features typically cover a broad range of time scales and exhibit large diversity in different brain regions. It remains unclear what is the computational benefit for the brain to have such variability in short-term dynamics. In this study, we propose that the brain can exploit such dynamical features to implement multiple seemingly contradictory computations in a single neural circuit. To demonstrate this idea, we use continuous attractor neural network (CANN) as a working model and include STF, SFA and STD with increasing time constants in its dynamics. Three computational tasks are considered, which are persistent activity, adaptation, and anticipative tracking. These tasks require conflicting neural mechanisms, and hence cannot be implemented by a single dynamical feature or any combination with similar time constants. However, with properly coordinated STF, SFA and STD, we show that the network is able to implement the three computational tasks concurrently. We hope this study will shed light on the understanding of how the brain orchestrates its rich dynamics at various levels to realize diverse cognitive functions.

  13. Diffusion tensor imaging in the characterization of multiple system atrophy

    PubMed Central

    Rulseh, Aaron Michael; Keller, Jiri; Rusz, Jan; Syka, Michael; Brozova, Hana; Rusina, Robert; Havrankova, Petra; Zarubova, Katerina; Malikova, Hana; Jech, Robert; Vymazal, Josef

    2016-01-01

    Purpose Multiple system atrophy (MSA) is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI). Materials and methods Twenty MSA subjects, ten parkinsonian dominant (MSA-P), ten cerebellar dominant (MSA-C), and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values. Results We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA-P subgroups. Altered DTI metrics in the putamen and middle cerebellar peduncles were associated with a positive parkinsonian and cerebellar phenotype, respectively. Concerning clinical applicability, we achieved high classification performance on mean diffusivity data in the combined bilateral putamen and middle cerebellar peduncle (accuracy 90.3%±9%, sensitivity 86.5%±11%, and specificity 99.3%±4%). Conclusion DTI in the middle cerebellar peduncle and putamen may be used in the diagnosis of MSA with a high degree of accuracy. PMID:27616888

  14. Skin vasodilator response to local heating in multiple system atrophy.

    PubMed

    Yamanaka, Yoshitaka; Asahina, Masato; Mathias, Christopher J; Akaogi, Yuichi; Koyama, Yu; Hattori, Takamichi

    2007-12-01

    Local heating of nonglabrous skin increases skin blood flow (SkBF) in two phases. The initial peak (P1) is mediated by a sensory-axon reflex and the plateau phase (P2) by local production of substances such as nitric oxide. We evaluated the SkBF response to local heating in 15 multiple system atrophy (MSA) patients with autonomic failure and 12 age-matched healthy controls. The mean ratio of SkBF at P1 to that at baseline (SkBF(P1)/SkBF(base) ratio) in MSA was significantly lower than that in controls (P < 0.01). The mean ratio of SkBF at P2 seemed to be slightly reduced in the MSA patients, compared with controls, although there was no significant difference. The P1 phase is thought to be mediated by a sensory-axon reflex modulated by sympathetic nerve activity. These findings are indicative of the skin sympathetic vasomotor dysfunction in MSA.

  15. Neural Computations in a Dynamical System with Multiple Time Scales

    PubMed Central

    Mi, Yuanyuan; Lin, Xiaohan; Wu, Si

    2016-01-01

    Neural systems display rich short-term dynamics at various levels, e.g., spike-frequency adaptation (SFA) at the single-neuron level, and short-term facilitation (STF) and depression (STD) at the synapse level. These dynamical features typically cover a broad range of time scales and exhibit large diversity in different brain regions. It remains unclear what is the computational benefit for the brain to have such variability in short-term dynamics. In this study, we propose that the brain can exploit such dynamical features to implement multiple seemingly contradictory computations in a single neural circuit. To demonstrate this idea, we use continuous attractor neural network (CANN) as a working model and include STF, SFA and STD with increasing time constants in its dynamics. Three computational tasks are considered, which are persistent activity, adaptation, and anticipative tracking. These tasks require conflicting neural mechanisms, and hence cannot be implemented by a single dynamical feature or any combination with similar time constants. However, with properly coordinated STF, SFA and STD, we show that the network is able to implement the three computational tasks concurrently. We hope this study will shed light on the understanding of how the brain orchestrates its rich dynamics at various levels to realize diverse cognitive functions. PMID:27679569

  16. Comparison of PSF maxima and minima of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems

    NASA Astrophysics Data System (ADS)

    Ratnam, Challa; Lakshmana Rao, Vadlamudi; Lachaa Goud, Sivagouni

    2006-10-01

    In the present paper, and a series of papers to follow, the Fourier analytical properties of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems are investigated. First, the transmission function for MACA and CMACA is derived using Fourier methods and, based on the Fresnel-Kirchoff diffraction theory, the formulae for the point spread function are formulated. The PSF maxima and minima are calculated for both the MACA and CMACA systems. The dependence of these properties on the number of zones is studied and reported in this paper.

  17. Multiple system atrophy: alpha-synuclein and neuronal degeneration.

    PubMed

    Yoshida, Mari

    2007-10-01

    Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that encompasses olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy-Drager syndrome (SDS). The histopathological hallmark is the formation of alpha-synuclein-positive glial cytoplasmic inclusions (GCIs) in oligodendroglia. alpha-synuclein aggregation is also found in glial nuclear inclusions, neuronal cytoplasmic inclusions (NCIs), neuronal nuclear inclusions (NNIs) and dystrophic neurites. We evaluated the pathological features of 102 MSA cases, and presented the pathological spectrum of MSA and initial features of alpha-synuclein accumulation. We found that 39% of the 102 cases showed equivalent SND and OPCA pathologies, 33% showed OPCA- and 22% showed SND-predominant pathology, whereas 6% showed extremely mild changes. Our pathological analysis indicated that OPCA-type was relatively more frequent and SND-type was less frequent in Japanese MSA cases, compared to the relatively high frequency of SND-type in Western countries, suggesting that different phenotypic patterns of MSA may exist between races. In the early stage, in addition to GCIs, NNIs and diffuse homogenous alpha-synuclein staining in neuronal nuclei and cytoplasm were observed in lesions in the pontine nuclei, putamen, substantia nigra, locus ceruleus, inferior olivary nucleus, intermediolateral column of thoracic spinal cord, lower motor neurons and cortical pyramidal neurons. A subgroup of MSA cases with severe temporal atrophy showed numerous NCIs, particularly in the limbic system. These findings suggest that primary non-fibrillar and fibrillar alpha-synuclein aggregation also occur in neurons. The oligo-myelin-axon-neuron complex mechanism, along with the direct involvement of neurons themselves, may synergistically accelerate the degenerative process of MSA. PMID:18018485

  18. TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis

    PubMed Central

    García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Suardíaz, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Álvarez-Lafuente, Roberto; Urcelay, Elena

    2011-01-01

    The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10−4, OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10−5, OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS. PMID:21814551

  19. CoRoT LRa02_E2_0121: Neptune-size planet candidate turns into a hierarchical triple system with a giant primary

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Santerne, A.; Mazeh, T.; Bouchy, F.; Moutou, C.; Alonso, R.; Gandolfi, D.; Aigrain, S.; Auvergne, M.; Barge, P.; Bonomo, A. S.; Bordé, P.; Deeg, H.; Ferraz-Mello, S.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Tsodikovich, Y.; Wuchterl, G.

    2011-10-01

    This paper presents the case of CoRoT LRa02_E2_0121, which was initially classified as a Neptune-size transiting-planet candidate on a relatively wide orbit of 36.3 days. Follow-up observations were performed with UVES, Sandiford, SOPHIE, and HARPS. These observations revealed a faint companion in the spectra. To find the true nature of the system we derived the radial velocities of the faint companion using TODMOR - a two-dimensional correlation technique, applied to the SOPHIE spectra. Modeling the lightcurve with EBAS we discovered a secondary eclipse with a depth of ~0.07%, indicating a diluted eclipsing binary. Combined MCMC modeling of the lightcurve and the radial velocities suggested that CoRoT LRa02_E2_0121 is a hierarchical triple system with an evolved G-type primary and an A-type:F-type grazing eclipsing binary. Such triple systems are difficult to discover. Based on observations made with the 1.93-m telescope at Observatoire de Haute-Provence (CNRS), France, the 3.6-m telescope at La Silla Observatory (ESO), Chile (program 184.C-0639), the VLT at Paranal Observatory (ESO), Chile (program 083.C-0690), and the 2.1-m Otto Struve telescope at McDonald Observatory, Texas, USA.

  20. A hierarchical approach to fisheries planning and modeling in the Columbia River Basin

    NASA Astrophysics Data System (ADS)

    Lee, Danny C.; Grant, William E.

    1995-01-01

    The Columbia River Basin is the scene of a massive effort to restore populations of Pacific salmon ( Oncorhynchus spp.) and steelhead ( O. mykiss). Efficient restoration is confounded by a high level of complexity, competing sociopolitical goals and values, and uncertainty about key system properties. Simulation models and other tools of systems analysis are important to development of a comprehensive, regionally acceptable strategy. Hierarchy theory provides a useful paradigm for organized complexity within the Columbia Basin and the basis for a trilevel hierarchical structure for organizing and integrating models. Life-stage models compose the most basic simulation units at the lowest level in the proposed hierarchical modeling structure. Each life-stage model simulates a distinct period in the life cycle of anadromous salmonids. Population models at the intermediate level simulate the complete life cycles of salmon and steelhead populations. At the highest level in the hierarchy, interpopulation models simulate extensive, long-term processes that affect multiple species and stocks. A hierarchical system of models is preferable to a single model or to a group of models lacking formal structure. A principal advantage is that models have the correct spatial and temporal resolution for analyzing questions at different scales. A hierarchical structure also facilitates the flow of information among models, and aids in understanding the impacts of uncertainty. Constructing a hierarchy of models should involve both bottom-up and top-down perspectives that maintain logical consistency among models, while allowing unique model structures appropriate for each level in the hierarchy.