Sample records for high efficiency usc

  1. High-Performance Flexible Perovskite Solar Cells by Using a Combination of Ultrasonic Spray-Coating and Low Thermal Budget Photonic Curing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanjib, Das; Yang, Bin; Gu, Gong

    Realizing the commercialization of high-performance and robust perovskite solar cells urgently requires the development of economically scalable processing techniques. Here we report a high-throughput ultrasonic spray-coating (USC) process capable of fabricating perovskite film-based solar cells on glass substrates with power conversion efficiency (PCE) as high as 13.04%. Perovskite films with high uniformity, crystallinity, and surface coverage are obtained in a single step. Moreover, we report USC processing on TiOx/ITO-coated polyethylene terephthalate (PET) substrates to realize flexible perovskite solar cells with PCE as high as 8.02% that are robust under mechanical stress. In this case, an optical curing technique was usedmore » to achieve a highly-conductive TiOx layer on flexible PET substrates for the first time. The high device performance and reliability obtained by this combination of USC processing with optical curing appears very promising for roll-to-roll manufacturing of high-efficiency, flexible perovskite solar cells.« less

  2. 78 FR 44247 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... (energy efficiency standards) Distribution Transformers (energy efficiency standards) Residential... Sequence No. Title Identifier No. 130 Energy Efficiency 1904-AC04 Standards for Distribution Transformers... Transformers Legal Authority: 42 U.S.C. 6317(a); 42 U.S.C. 6313(a)(6)(C) Abstract: The current distribution...

  3. United States Advanced Ultra-Supercritical Component Test Facility for 760°C Steam Power Plants ComTest Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hack, Horst; Purgert, Robert Michael

    Following the successful completion of a 15-year effort to develop and test materials that would allow coal-fired power plants to be operated at advanced ultra-supercritical (A-USC) steam conditions, a United States-based consortium is presently engaged in a project to build an A-USC component test facility (ComTest). A-USC steam cycles have the potential to improve cycle efficiency, reduce fuel costs, and reduce greenhouse gas emissions. Current development and demonstration efforts are focused on enabling the construction of A-USC plants, operating with steam temperatures as high as 1400°F (760°C) and steam pressures up to 5000 psi (35 MPa), which can potentially increasemore » cycle efficiencies to 47% HHV (higher heating value), or approximately 50% LHV (lower heating value), and reduce CO 2 emissions by roughly 25%, compared to today’s U.S. fleet. A-USC technology provides a lower-cost method to reduce CO 2 emissions, compared to CO 2 capture technologies, while retaining a viable coal option for owners of coal generation assets. Among the goals of the ComTest facility are to validate that components made from advanced nickel-based alloys can operate and perform under A-USC conditions, to accelerate the development of a U.S.-based supply chain for the full complement of A-USC components, and to decrease the uncertainty of cost estimates for future A-USC power plants. The configuration of the ComTest facility would include the key A-USC technology components that were identified for expanded operational testing, including a gas-fired superheater, high-temperature steam piping, steam turbine valve, and cycling header component. Membrane walls in the superheater have been designed to operate at the full temperatures expected in a commercial A-USC boiler, but at a lower (intermediate) operating pressure. This superheater has been designed to increase the temperature of the steam supplied by the host utility boiler up to 1400°F (760°C). The steam turbine stop and control valve component has been designed to operate at full A-USC temperatures, and would be tested both in throttling operation and to accumulate accelerated, repetitive stroke cycles. A cycling header component has been designed to confirm the suitability of new high-temperature nickel alloys to cycling operation, expected of future coal-fired power plants. Current test plans would subject these components to A-USC operating conditions for at least 8,000 hours by September 2020. The ComTest project is managed by Energy Industries of Ohio, and technically directed by the Electric Power Research Institute, Inc., with General Electric designing the A-USC components. This consortium is completing the Detailed Engineering phase of the project, with procurement scheduled to begin in late 2017. The effort is primarily funded by the U.S. Department of Energy, through the National Energy Technology Laboratory, along with the Ohio Development Services Agency. This presentation outlines the motivation for the project, explains the project’s structure and schedule, and provides technical details on the design of the ComTest facility.« less

  4. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (33 U.S.C. 1251 et seq.); (iii) Safe Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  5. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  6. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  7. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  8. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  9. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b, 8262g...

  10. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b, 8262g...

  11. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b, 8262g...

  12. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b, 8262g...

  13. 48 CFR 23.201 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.201 Authorities. (a) Energy... U.S.C. 6901, et seq.). (b) National Energy Conservation Policy Act (42 U.S.C. 8253, 8259b, 8262g...

  14. 1300°F 800 MWe USC CFB Boiler Design Study

    NASA Astrophysics Data System (ADS)

    Robertson, Archie; Goidich, Steve; Fan, Zhen

    Concern about air emissions and the effect on global warming is one of the key factors for developing and implementing new advanced energy production solutions today. One state-of-the-art solution is circulating fluidized bed (CFB) combustion technology combined with a high efficiency once-through steam cycle. Due to this extremely high efficiency, the proven CFB technology offers a good solution for CO2 reduction. Its excellent fuel flexibility further reduces CO2 emissions by co-firing coal with biomass. Development work is under way to offer CFB technology up to 800MWe capacities with ultra-supercritical (USC) steam parameters. In 2009 a 460MWe once-through supercritical (OTSC) CFB boiler designed and constructed by Foster Wheeler will start up. However, scaling up the technology further to 600-800MWe with net efficiency of 45-50% is needed to meet the future requirements of utility operators. To support the move to these larger sizes, an 800MWe CFB boiler conceptual design study was conducted and is reported on herein. The use of USC conditions (˜11 00°F steam) was studied and then the changes, that would enable the unit to generate 1300°F steam, were identified. The study has shown that by using INTREX™ heat exchangers in a unique internal-external solids circulation arrangement, Foster Wheeler's CFB boiler configuration can easily accommodate 1300°F steam and will not require a major increase in heat transfer surface areas.

  15. Trends in the Types of Usual Sources of Care: A Shift from People to Places or Nothing at All.

    PubMed

    Liaw, Winston; Jetty, Anuradha; Petterson, Stephen; Bazemore, Andrew; Green, Larry

    2017-08-31

    (1) To examine usual source of care (USC) trends across four categories (No USC, Person USC, Person, in Facility USC, and Facility USC), and (2) to determine whether USC types are associated with emergency department (ED) visits and hospital admissions. 1996-2014 Medical Expenditure Panel Surveys. We stratified each USC category, by age, region, gender, poverty, insurance, race/ethnicity, and education and used regression to determine the characteristics associated with USC types, ED visits, and hospital admissions. Those with No USC and Facility USCs increased 10 and 18 percent, respectively, while those with Person USCs decreased by 43 percent. Compared to those in the lowest income bracket, those in the highest income bracket were less likely to have a Facility USC. Among those with low incomes, individuals with No USC, Person, in Facility, and Facility USCs were more likely to have ED visits than those with Person USCs. A growing number are reporting facilities as their USCs or none at all. The impact of these trends is uncertain, although we found that some USC types are associated with ED visits and hospital admissions. Tracking USCs will be crucial to measuring progress toward enhanced care efficiency. © Health Research and Educational Trust.

  16. 75 FR 71570 - Energy Conservation Program: Test Procedures for Fluorescent Lamp Ballasts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... improve energy efficiency. Part A of Title III (42 U.S.C. 6291-6309) establishes the ``Energy Conservation... ballasts (ballasts). (42 U.S.C. 6291(1), (2) and 6292(a)(13)) Under EPCA, the overall program consists... the public an opportunity to present oral and written comments on them. (42 U.S.C. 6293(b)(2)) Finally...

  17. Materials for Advanced Ultra-supercritical (A-USC) Steam Turbines – A-USC Component Demonstration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Purgert, Robert; Phillips, Jeffrey; Hendrix, Howard

    The work by the United States Department of Energy (U.S. DOE)/Ohio Coal Development Office (OCDO) advanced ultra-supercritical (A-USC) Steam Boiler and Turbine Materials Consortia from 2001 through September 2015 was primarily focused on lab scale and pilot scale materials testing. This testing included air- or steam-cooled “loops” that were inserted into existing utility boilers to gain exposure of these materials to realistic conditions of high temperature and corrosion due to the constituents in the coal. Successful research and development resulted in metallic alloy materials and fabrication processes suited for power generation applications with metal temperatures up to approximately 1472°F (800°C).more » These materials or alloys have shown, in extensive laboratory tests and shop fabrication studies, to have excellent applicability for high-efficiency low CO 2 transformational power generation technologies previously mentioned. However, as valuable as these material loops have been for obtaining information, their scale is significantly below that required to minimize the risk associated with a power company building a multi-billion dollar A-USC power plant. To decrease the identified risk barriers to full-scale implementation of these advanced materials, the U.S. DOE/OCDO A-USC Steam Boiler and Turbine Materials Consortia identified the key areas of the technology that need to be tested at a larger scale. Based upon the recommendations and outcome of a Consortia-sponsored workshop with the U.S.’s leading utilities, a Component Test (ComTest) Program for A-USC was proposed. The A-USC ComTest program would define materials performance requirements, plan for overall advanced system integration, design critical component tests, fabricate components for testing from advanced materials, and carry out the tests. The AUSC Component Test was premised on the program occurring at multiple facilities, with the operating temperatures, pressure and/or size of these components determining the optimum test location. The first step of the ComTest, the steam turbine test, was determined best suited for a site in Youngstown, Ohio. Efforts were also undertaken to identify and evaluate other potential sites for high pressure testing.« less

  18. 78 FR 73737 - Energy Efficiency Program for Consumer Products: Energy Conservation Standards for General...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ..., and time needed to revise sales and marketing strategies. (42 U.S.C. 6295(i)(6)(A)(iv)) Further, for... contracts, workers, raw materials, and time needed to revise sales and marketing strategies. (42 U.S.C. 6295...

  19. 77 FR 47897 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Granting Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... impact on efficiency, competition, and capital formation. See 15 U.S.C. 78c(f). \\8\\ 15 U.S.C. 78f(b)(5... that according to the ISE, each set of CMM quotes will have independent quoting obligations, and thus...

  20. Review of the coal-fired, over-supercritical and ultra-supercritical steam power plants

    NASA Astrophysics Data System (ADS)

    Tumanovskii, A. G.; Shvarts, A. L.; Somova, E. V.; Verbovetskii, E. Kh.; Avrutskii, G. D.; Ermakova, S. V.; Kalugin, R. N.; Lazarev, M. V.

    2017-02-01

    The article presents a review of developments of modern high-capacity coal-fired over-supercritical (OSC) and ultra-supercritical (USC) steam power plants and their implementation. The basic engineering solutions are reported that ensure the reliability, economic performance, and low atmospheric pollution levels. The net efficiency of the power plants is increased by optimizing the heat balance, improving the primary and auxiliary equipment, and, which is the main thing, by increasing the throttle conditions. As a result of the enhanced efficiency, emissions of hazardous substances into the atmosphere, including carbon dioxide, the "greenhouse" gas, are reduced. To date, the exhaust steam conditions in the world power industry are p 0 ≈ 30 MPa and t 0 = 610/620°C. The efficiency of such power plants reaches 47%. The OSC plants are being operated in Germany, Denmark, Japan, China, and Korea; pilot plants are being developed in Russia. Currently, a project of a power plant for the ultra-supercritical steam conditions p 0 ≈ 35 MPa and t 0 = 700/720°C with efficiency of approximately 50% is being studied in the EU within the framework of the Thermie AD700 program, project AD 700PF. Investigations in this field have also been launched in the United States, Japan, and China. Engineering solutions are also being sought in Russia by the All-Russia Thermal Engineering Research Institute (VTI) and the Moscow Power Engineering Institute. The stated steam parameter level necessitates application of new materials, namely, nickel-base alloys. Taking into consideration high costs of nickel-base alloys and the absence in Russia of technologies for their production and manufacture of products from these materials for steam-turbine power plants, the development of power plants for steam parameters of 32 MPa and 650/650°C should be considered to be the first stage in creating the USC plants as, to achieve the above parameters, no expensive alloys are require. To develop and construct OSC and USC head power plants, joint efforts of the government, experts in power industry and metallurgy, scientific institutions, and equipment manufacturers are required.

  1. 76 FR 16650 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving Proposed Rule Change To Amend...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... investors and the public interest; and are not designed to permit unfair discrimination among customers... proposed rule's impact on efficiency, competition, and capital formation. 15 U.S.C. 78c(f). \\9\\ 15 U.S.C... between customers based on the nature and profitability of their business. Currently under BOX's rules, an...

  2. 15 CFR 904.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Bass Conservation Act, 16 U.S.C. 1851 note; (9) Atlantic Tunas Convention Act of 1975, 16 U.S.C. 971... Seal Act Amendments of 1983, 16 U.S.C. 1151-1175; (18) High Seas Fishing Compliance Act, 16 U.S.C. 5506...

  3. 15 CFR 904.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Bass Conservation Act, 16 U.S.C. 1851 note; (9) Atlantic Tunas Convention Act of 1975, 16 U.S.C. 971... Seal Act Amendments of 1983, 16 U.S.C. 1151-1175; (18) High Seas Fishing Compliance Act, 16 U.S.C. 5506...

  4. Materials for advanced ultrasupercritical steam turbines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Purgert, Robert; Shingledecker, John; Saha, Deepak

    The U.S. Department of Energy (DOE) and the Ohio Coal Development Office (OCDO) have sponsored a project aimed at identifying, evaluating, and qualifying the materials needed for the construction of the critical components of coal-fired power plants capable of operating at much higher efficiencies than the current generation of supercritical plants. This increased efficiency is expected to be achieved principally through the use of advanced ultrasupercritical (A-USC) steam conditions. A limiting factor in this can be the materials of construction for boilers and for steam turbines. The overall project goal is to assess/develop materials technology that will enable achieving turbinemore » throttle steam conditions of 760°C (1400°F)/35MPa (5000 psi). This final technical report covers the research completed by the General Electric Company (GE) and Electric Power Research Institute (EPRI), with support from Oak Ridge National Laboratory (ORNL) and the National Energy Technology Laboratory (NETL) – Albany Research Center, to develop the A-USC steam turbine materials technology to meet the overall project goals. Specifically, this report summarizes the industrial scale-up and materials property database development for non-welded rotors (disc forgings), buckets (blades), bolting, castings (needed for casing and valve bodies), casting weld repair, and casting to pipe welding. Additionally, the report provides an engineering and economic assessment of an A-USC power plant without and with partial carbon capture and storage. This research project successfully demonstrated the materials technology at a sufficient scale and with corresponding materials property data to enable the design of an A-USC steam turbine. The key accomplishments included the development of a triple-melt and forged Haynes 282 disc for bolted rotor construction, long-term property development for Nimonic 105 for blading and bolting, successful scale-up of Haynes 282 and Nimonic 263 castings using traditional sand foundry practices, and a techno-economic study of an A-USC plant including cost estimates for an A-USC turbine which showed A-USC to be economically attractive for partial carbon and capture compared to today’s USC technology. Based on this successful materials research and a review with U.S. utility stakeholders, a new project to develop a component test facility (ComTest) including the world’s first A-USC turbine has been proposed to continue the technology development.« less

  5. Recent Achievements of the Collaboratory for the Study of Earthquake Predictability

    NASA Astrophysics Data System (ADS)

    Jackson, D. D.; Liukis, M.; Werner, M. J.; Schorlemmer, D.; Yu, J.; Maechling, P. J.; Zechar, J. D.; Jordan, T. H.

    2015-12-01

    Maria Liukis, SCEC, USC; Maximilian Werner, University of Bristol; Danijel Schorlemmer, GFZ Potsdam; John Yu, SCEC, USC; Philip Maechling, SCEC, USC; Jeremy Zechar, Swiss Seismological Service, ETH; Thomas H. Jordan, SCEC, USC, and the CSEP Working Group The Collaboratory for the Study of Earthquake Predictability (CSEP) supports a global program to conduct prospective earthquake forecasting experiments. CSEP testing centers are now operational in California, New Zealand, Japan, China, and Europe with 435 models under evaluation. The California testing center, operated by SCEC, has been operational since Sept 1, 2007, and currently hosts 30-minute, 1-day, 3-month, 1-year and 5-year forecasts, both alarm-based and probabilistic, for California, the Western Pacific, and worldwide. We have reduced testing latency, implemented prototype evaluation of M8 forecasts, and are currently developing formats and procedures to evaluate externally-hosted forecasts and predictions. These efforts are related to CSEP support of the USGS program in operational earthquake forecasting and a DHS project to register and test external forecast procedures from experts outside seismology. A retrospective experiment for the 2010-2012 Canterbury earthquake sequence has been completed, and the results indicate that some physics-based and hybrid models outperform purely statistical (e.g., ETAS) models. The experiment also demonstrates the power of the CSEP cyberinfrastructure for retrospective testing. Our current development includes evaluation strategies that increase computational efficiency for high-resolution global experiments, such as the evaluation of the Global Earthquake Activity Rate (GEAR) model. We describe the open-source CSEP software that is available to researchers as they develop their forecast models (http://northridge.usc.edu/trac/csep/wiki/MiniCSEP). We also discuss applications of CSEP infrastructure to geodetic transient detection and how CSEP procedures are being adapted to ground motion prediction experiments.

  6. 76 FR 40050 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... analyses: Energy Efficiency Standards for Certain Commercial and Industrial Electric Motors. Issued in... for Certain Commercial and Industrial Electric Motors. DEPARTMENT OF ENERGY (DOE) Energy Efficiency... and Industrial Electric Motors Legal Authority: 42 U.S.C. 6313(b)(4)(B) Abstract: The Energy...

  7. Department of Energy Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Water Heaters; and (2) Energy Efficiency Standards for Certain Commercial and Industrial Electric Motors... Standards for Certain Commercial and Industrial Electric Motors..... 1904-AC28 Energy Efficiency and... FOR CERTAIN COMMERCIAL AND INDUSTRIAL ELECTRIC MOTORS Legal Authority: 42 USC 6313(b)(4)(B) Abstract...

  8. 75 FR 79759 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Efficiency Standards for Certain Commercial and Industrial Electric Motors. The Plan appears in both the... Commercial and Industrial Electric Motors..... 1904-AC28 Energy Efficiency and Renewable Energy--Completed... COMMERCIAL AND INDUSTRIAL ELECTRIC MOTORS Legal Authority: 42 USC 6313(b)(4)(B) Abstract: The Energy Policy...

  9. Ultrasound-assisted extraction and quantitation of oils from Syzygium aromaticum flower bud (clove) with supercritical carbon dioxide.

    PubMed

    Yang, Yu-Chiao; Wei, Ming-Chi; Hong, Show-Jen

    2014-01-03

    This study evaluated ultrasound-assisted supercritical carbon dioxide (USC-CO2) extraction for determining the extraction yields of oils and the contents of eugenol, β-caryophyllene, eugenyl acetate and α-humulene from clove buds. Compared to traditional SC-CO2 extraction, USC-CO2 extraction might provide a 13.5% increase in the extraction yield for the oil while utilizing less severe operating parameters, such as temperature, pressure, CO2 flow rate and the time consumed by the process. Our results were comparable to those obtained using the heat reflux extraction method, though the yield was improved by 20.8% using USC-CO2. In kinetic studies, the USC-CO2 extraction of clove oil followed second-order kinetics. The activation energy for the oil extraction was 76.56kJ/mol. The USC-CO2 procedure facilitated the use of mild extraction conditions, improved extraction efficiency and the quality of products and is a potential method for industry. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. T-DM1, a novel antibody–drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo

    PubMed Central

    English, Diana P; Bellone, Stefania; Schwab, Carlton L; Bortolomai, Ileana; Bonazzoli, Elena; Cocco, Emiliano; Buza, Natalia; Hui, Pei; Lopez, Salvatore; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Santin, Alessandro D

    2014-01-01

    Amplification of c-erbB2 has been reported in over 30% of uterine serous carcinoma (USC) and found to confer poor survival because of high proliferation and increased resistance to therapy. In this study, we evaluated for the first time Trastuzumab emtansine (T-DM1), a novel antibody–drug conjugate, against multiple epidermal growth factor receptor-2 (HER2)-positive USC cells in vitro followed by developing a supportive in vivo model. Fifteen primary USC cell lines were assessed by immunohistochemistry (IHC) and flow cytometry for HER2 protein expression. C-erbB2 gene amplification was evaluated using fluorescent in situ hybridization. Sensitivity to T-DM1 and trastuzumab (T)-induced antibody-dependent cell-mediated cytotoxicity was evaluated in 5-h chromium release assays. T-DM1 and T cytostatic and apoptotic activities were evaluated using flow-cytometry-based proliferation assays. In vivo activity of T-DM1 versus T in USC xenografts in SCID mice was also evaluated. High levels of HER2 protein overexpression and HER2 gene amplification were detected in 33% of USC cell lines. T-DM1 was considerably more effective than trastuzumab in inhibiting cell proliferation and in causing apoptosis (P = 0.004) of USC showing HER2 overexpression. Importantly, T-DM1 was highly active at reducing tumor formation in vivo in USC xenografts overexpressing HER2 (P = 0.04) and mice treated with TDM-1 had significantly longer survival when compared to T-treated mice and control mice (P ≤ 0.0001). T-DM1 shows promising antitumor effect in HER2-positive USC cell lines and USC xenografts and its activity is significantly higher when compared to T. T-DM1 may represent a novel treatment option for HER2-positive USC patients with disease refractory to trastuzumab and traditional chemotherapy. PMID:24890382

  11. T-DM1, a novel antibody-drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo.

    PubMed

    English, Diana P; Bellone, Stefania; Schwab, Carlton L; Bortolomai, Ileana; Bonazzoli, Elena; Cocco, Emiliano; Buza, Natalia; Hui, Pei; Lopez, Salvatore; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Santin, Alessandro D

    2014-10-01

    Amplification of c-erbB2 has been reported in over 30% of uterine serous carcinoma (USC) and found to confer poor survival because of high proliferation and increased resistance to therapy. In this study, we evaluated for the first time Trastuzumab emtansine (T-DM1), a novel antibody-drug conjugate, against multiple epidermal growth factor receptor-2 (HER2)-positive USC cells in vitro followed by developing a supportive in vivo model. Fifteen primary USC cell lines were assessed by immunohistochemistry (IHC) and flow cytometry for HER2 protein expression. C-erbB2 gene amplification was evaluated using fluorescent in situ hybridization. Sensitivity to T-DM1 and trastuzumab (T)-induced antibody-dependent cell-mediated cytotoxicity was evaluated in 5-h chromium release assays. T-DM1 and T cytostatic and apoptotic activities were evaluated using flow-cytometry-based proliferation assays. In vivo activity of T-DM1 versus T in USC xenografts in SCID mice was also evaluated. High levels of HER2 protein overexpression and HER2 gene amplification were detected in 33% of USC cell lines. T-DM1 was considerably more effective than trastuzumab in inhibiting cell proliferation and in causing apoptosis (P = 0.004) of USC showing HER2 overexpression. Importantly, T-DM1 was highly active at reducing tumor formation in vivo in USC xenografts overexpressing HER2 (P = 0.04) and mice treated with TDM-1 had significantly longer survival when compared to T-treated mice and control mice (P ≤ 0.0001). T-DM1 shows promising antitumor effect in HER2-positive USC cell lines and USC xenografts and its activity is significantly higher when compared to T. T-DM1 may represent a novel treatment option for HER2-positive USC patients with disease refractory to trastuzumab and traditional chemotherapy. © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  12. Department of Energy Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...: Energy Efficiency Standards for Pool Heaters and Direct Heating Equipment and Water Heaters, and Test... EFFICIENCY STANDARDS FOR POOL HEATERS AND DIRECT HEATING EQUIPMENT AND WATER HEATERS Legal Authority: 42 USC... and direct heating equipment. This is the second review for water heaters. Timetable: Action Date FR...

  13. 75 FR 37287 - Privacy Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ...The Recovery Accountability and Transparency Board (Board) amends its regulations implementing the Privacy Act of 1974 (Privacy Act), Public Law 93-579, 5 U.S.C. 552a. This final rule adds 4 CFR 200.17 to exempt certain systems of records from certain sections of the Privacy Act (5 U.S.C. 552a) pursuant to 5 U.S.C. 552a(j) and (k). These exemptions will help ensure that the Board may efficiently and effectively compile investigatory material to prevent and detect fraud, waste, and abuse and perform its other authorized duties and activities relating to oversight of funds awarded pursuant to the American Recovery and Reinvestment Act of 2009, Public Law 111-5 (Feb. 17, 2009) (Recovery Act).

  14. 77 FR 38040 - Reestablishment of the Renewable Energy and Energy Efficiency Advisory Committee and Solicitation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... DEPARTMENT OF COMMERCE International Trade Administration Reestablishment of the Renewable Energy... of Reestablishment of the Renewable Energy and Energy Efficiency Advisory Committee and Solicitation... Act, 5 U.S.C. App., the Department of Commerce announces the reestablishment of the Renewable Energy...

  15. Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab.

    PubMed

    Todeschini, P; Cocco, E; Bellone, S; Varughese, J; Lin, K; Carrara, L; Guzzo, F; Buza, N; Hui, P; Silasi, D-A; Ratner, E; Azodi, M; Schwartz, P E; Rutherford, T J; Pecorelli, S; Santin, A D

    2011-10-11

    We evaluated shedding of epidermal growth factor type II receptor (Her2/neu) extracellular domain (ECD) in primary uterine serous carcinoma (USC) cell lines and in the serum of USC patients and its biological effects in experiments of trastuzumab-induced cytotoxicity in vitro. Her2/neu expression was evaluated by immunohistochemistry (IHC), real-time PCR and flow cytometry, while c-erbB2 gene amplification was assessed using fluorescent in situ hybridisation (FISH). Her2/neu ECD levels in the supernatants of USC cell lines and in the serum of 38 USC patients and 19 controls were tested using ELISA. The biologic effect of Her2/neu ECD on trastuzumab-induced antibody-dependent cell-mediated cytotoxicity (ADCC) was evaluated in 5-h chromium-release assays. Five out of ten USC cell lines overexpressed Her2/neu by IHC and showed amplification of the c-erbB2 gene. High levels of Her2/neu ECD were found in supernatants of all FISH-positive tumours. In contrast, FISH-negative USC was negative for Her2/neu ECD shedding. Serum Her2/neu ECD levels in patients harbouring 3+Her2/neu tumours were higher than those found in healthy women (P=0.02) or USC patients with 2+ or 1+/negative Her2/neu expression (P=0.02). In cytotoxicity experiments, trastuzumab-mediated ADCC was significantly decreased by the addition of Her2/neu ECD-containing supernatants (P=0.01). FISH-positive c-erbB2 USC cell lines shed high levels of Her2/neu ECD. High levels of Her2/neu ECD in USC patients may reduce trastuzumab-mediated ADCC in vitro and potentially neutralise its therapeutic effect in vivo.

  16. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... development of technologies identified as critical under 10 U.S.C. 2522. (6) Increase the development and promotion of efficient and effective applications of dual-use technologies. (7) Provide efficient and... and life-cycle costs of military systems. (3) Strengthen the defense industrial and technology base of...

  17. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... development of technologies identified as critical under 10 U.S.C. 2522. (6) Increase the development and promotion of efficient and effective applications of dual-use technologies. (7) Provide efficient and... and life-cycle costs of military systems. (3) Strengthen the defense industrial and technology base of...

  18. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... development of technologies identified as critical under 10 U.S.C. 2522. (6) Increase the development and promotion of efficient and effective applications of dual-use technologies. (7) Provide efficient and... and life-cycle costs of military systems. (3) Strengthen the defense industrial and technology base of...

  19. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... development of technologies identified as critical under 10 U.S.C. 2522. (6) Increase the development and promotion of efficient and effective applications of dual-use technologies. (7) Provide efficient and... and life-cycle costs of military systems. (3) Strengthen the defense industrial and technology base of...

  20. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... development of technologies identified as critical under 10 U.S.C. 2522. (6) Increase the development and promotion of efficient and effective applications of dual-use technologies. (7) Provide efficient and... and life-cycle costs of military systems. (3) Strengthen the defense industrial and technology base of...

  1. Annual Report on Federal Government Energy Management and Conservation Programs, Fiscal Year 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  2. Federal Government Energy Management and Conservation Programs Fiscal Year 2009

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  3. Annual Report on Federal Government Energy Management and Conservation Programs, Fiscal Year 2011

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  4. Federal Government Energy Management and Conservation Programs Fiscal Year 2008

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  5. Annual Report on Federal Government Energy Management and Conservation Programs, Fiscal Year 2010

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  6. Annual Report on Federal Government Energy Management and Conservation Programs, Fiscal Year 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Annual reports on Federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in Federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities conducted by Federal agencies under the: Energy management and energy consumption requirements of section 543 of NECPA, as amended (42 U.S.C. § 8253); Energy savings performance contract authority of section 801 of NECPA, Pub. L. No. 95-619, as amended (42 U.S.C. §§ 8287-8287d); Renewable energy purchase goal of section 203 of the Energymore » Policy Act (EPAct) of 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 15852); Federal building performance standard requirements under Section 109 of EPAct 2005, Pub. L. No. 109-58 (codified at 42 U.S.C. § 6834(a)); Requirements on the procurement and identification of energy efficient products under section 161 of EPAct 1992, Pub. L. No. 102-486 (codified at 42 U.S.C. § 8262g); Sections 431, 432, and 434 of the Energy Independence and Security Act of 2007 (EISA), Pub. L. No. 110-140 (42 U.S.C. § 8253) and section 527 of EISA (42 U.S.C. § 17143); Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, 72 Fed. Reg. 3,919 (Jan. 26, 2007); Executive Order 13514, Federal Leadership in Environmental, Energy, and Economic Performance, 74 Fed. Reg. 52,117 (Oct. 5, 2009).« less

  7. Human urine-derived stem cells play a novel role in the treatment of STZ-induced diabetic mice.

    PubMed

    Zhao, Tianxue; Luo, Deng; Sun, Yun; Niu, Xin; Wang, Yang; Wang, Chen; Jia, Weiping

    2018-04-19

    Human urine-derived stem cells (hUSCs) are a potential stem cell source for cell therapy. However, the effect of hUSCs on glucose metabolism regulation in type 1 diabetes was not clear. Therefore, the aim of the study was to evaluate whether hUSCs have protective effect on streptozotocin (STZ)-induced diabetes. hUSCs were extracted and cultivated with a special culture medium. Flow cytometry analysis was applied to detect cell surface markers. BALB/c male nude mice were either injected with high-dose STZ (HD-STZ) or multiple low-dose STZ (MLD-STZ). Serum and pancreatic insulin were measured, islet morphology and its vascularization were investigated. hUSCs highly expressed CD29, CD73, CD90 and CD146, and could differentiate into, at least, bone and fat in vitro. Transplantation of hUSCs into HD-STZ treated mice prolonged the median survival time and improved their blood glucose, and into those with MLD-STZ improved the glucose tolerance, islet morphology and increased the serum and pancreas insulin content. Furthermore, CD31 expression increased significantly in islets of BALB/c nude mice treated with hUSCs compared to those of un-transplanted MLD-STZ mice. hUSCs could improve the median survival time and glucose homeostasis in STZ-treated mice through promoting islet vascular regeneration and pancreatic beta-cell survival.

  8. The USC Epigenome Center.

    PubMed

    Laird, Peter W

    2009-10-01

    The University of Southern California (USC, CA, USA) has a long tradition of excellence in epigenetics. With the recent explosive growth and technological maturation of the field of epigenetics, it became clear that a dedicated high-throughput epigenomic data production facility would be needed to remain at the forefront of epigenetic research. To address this need, USC launched the USC Epigenome Center as the first large-scale center in academics dedicated to epigenomic research. The Center is providing high-throughput data production for large-scale genomic and epigenomic studies, and developing novel analysis tools for epigenomic research. This unique facility promises to be a valuable resource for multidisciplinary research, education and training in genomics, epigenomics, bioinformatics, and translational medicine.

  9. 48 CFR 23.502 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.502 Authority. 41 U.S.C. chapter 81, Drug-Free Workplace. [79 FR 24208, Apr...

  10. BRCA germline mutations in women with uterine serous carcinoma--still a debate.

    PubMed

    Lavie, Ofer; Ben-Arie, Alon; Segev, Yakir; Faro, Jonathan; Barak, Frida; Haya, Nir; Auslender, Ron; Gemer, Ofer

    2010-12-01

    To determine the incidence of BRCA1 and BRCA2 mutations in an enlarged series of uterine serous carcinoma (USC) patients and to determine whether patients with USC are associated with a personal or familial history of breast or ovarian carcinoma. A cohort of all consecutive patients with diagnosed USC was identified for 9 years. Family pedigrees were drawn as far back and laterally as possible. In all patients, genomic DNA was extracted from peripheral blood samples and analyzed for the 3 mutations common in Ashkenazi Jewish patients. All patients went through total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Tubal, ovarian, and peritoneal carcinoma were ruled out clinically and pathologically in all patients. Of 51 consecutive patients with USC in Ashkenazi Jews studied, we identified 13 patients (25.5%) who were previously found to have breast carcinoma, 17 patients (33.3%) who had a first-degree relative with breast or ovarian carcinoma, and 8 patients (15.7%) who were found to be carriers of 1 of the 3 BRCA germline mutations. This series of USC patients, the largest consecutive series to date, suggests a higher incidence of BRCA carriers among Ashkenazi Jews as compared with the general population. This high rate of BRCA germline mutations in USC patients coupled with a high rate of personal and familial cancer histories may suggest that USC is associated with the hereditary breast-ovarian syndrome. This potential association of USC to the BRCA-associated cancer spectrum may have implications for the clinical management and intervention of unaffected BRCA1-2 germline mutation carriers. However, at the current time, there are insufficient data to provide evidence-based guidelines regarding the optimal timing or specific intervention to prevent cancers in these high-risk women.

  11. 75 FR 10873 - Energy Conservation Program: Energy Conservation Standards for Small Electric Motors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... design option to be technologically feasible if it is in use by the respective industry or if research.... Baseline Motor Performance 3. Higher Efficiency Motor Designs a. Electrical Steel b. Thermal Analysis c... a variety of provisions designed to improve energy efficiency. Part A of Title III (42 U.S.C. 6291...

  12. Human Urine Derived Stem Cells in Combination with β-TCP Can Be Applied for Bone Regeneration.

    PubMed

    Guan, Junjie; Zhang, Jieyuan; Li, Haiyan; Zhu, Zhenzhong; Guo, Shangchun; Niu, Xin; Wang, Yang; Zhang, Changqing

    2015-01-01

    Bone tissue engineering requires highly proliferative stem cells that are easy to isolate. Human urine stem cells (USCs) are abundant and can be easily harvested without using an invasive procedure. In addition, in our previous studies, USCs have been proved to be able to differentiate into osteoblasts, chondrocytes, and adipocytes. Therefore, USCs may have great potential and advantages to be applied as a cell source for tissue engineering. However, there are no published studies that describe the interactions between USCs and biomaterials and applications of USCs for bone tissue engineering. Therefore, the objective of the present study was to evaluate the interactions between USCs with a typical bone tissue engineering scaffold, beta-Tricalcium Phosphate (β-TCP), and to determine whether the USCs seeded onto β-TCP scaffold can promote bone regeneration in a segmental femoral defect of rats. Primary USCs were isolated from urine and seeded on β-TCP scaffolds. Results showed that USCs remained viable and proliferated within β-TCP. The osteogenic differentiation of USCs within the scaffolds was demonstrated by increased alkaline phosphatase activity and calcium content. Furthermore, β-TCP with adherent USCs (USCs/β-TCP) were implanted in a 6-mm critical size femoral defect of rats for 12 weeks. Bone regeneration was determined using X-ray, micro-CT, and histologic analyses. Results further demonstrated that USCs in the scaffolds could enhance new bone formation, which spanned bone defects in 5 out of 11 rats while β-TCP scaffold alone induced modest bone formation. The current study indicated that the USCs can be used as a cell source for bone tissue engineering as they are compatible with bone tissue engineering scaffolds and can stimulate the regeneration of bone in a critical size bone defect.

  13. Durability of Flexible Ureteroscopes: A Prospective Evaluation of Longevity, the Factors that Affect it, and Damage Mechanisms.

    PubMed

    Legemate, Jaap D; Kamphuis, Guido M; Freund, Jan Erik; Baard, Joyce; Zanetti, Stefano P; Catellani, Michele; Oussoren, Harry W; de la Rosette, Jean J

    2018-03-10

    Flexible ureteroscopy is an established treatment modality for evaluating and treating abnormalities in the upper urinary tract. Reusable ureteroscope (USC) durability is a significant concern. To evaluate the durability of the latest generation of digital and fiber optic reusable flexible USCs and the factors affecting it. Six new flexible USCs from Olympus and Karl Storz were included. The primary endpoint for each USC was its first repair. Data on patient and treatment characteristics, accessory device use, ureteroscopy time, image quality, USC handling, disinfection cycles, type of damage, and deflection loss were collected prospectively. Ureteroscopy. USC durability was measured as the total number of uses and ureteroscopy time before repair. USC handling and image quality were scored. After every procedure, maximal ventral and dorsal USC deflection were documented on digital images. A total of 198 procedures were performed. The median number of procedures was 27 (IQR 16-48; 14h) for the six USCs overall, 27 (IQR 20-56; 14h) for the digital USCs, and 24 (range 10-37; 14h) for the fiber optic USCs. Image quality remained high throughout the study for all six USCs. USC handling and the range of deflection remained good under incremental use. Damage to the distal part of the shaft and shaft coating was the most frequent reason for repair, and was related to intraoperative manual forcing. A limitation of this study is its single-center design. The durability of the latest reusable flexible USCs in the current study was limited to 27 uses (14h). Damage to the flexible shaft was the most important limitation to the durability of the USCs evaluated. Prevention of intraoperative manual forcing of flexible USCs maximizes their overall durability. Current flexible ureteroscopes proved to be durable. Shaft vulnerability was the most important limiting factor affecting durability. Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  14. 43 CFR 20.506 - Appropriations, legislation and lobbying.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., telephone, letter, printed or written matter, or other device, intended or designed to influence in any... appropriations which they deem necessary for the efficient conduct of the public business (18 U.S.C. 1913). (b...

  15. Linking uterine serous carcinoma to BRCA1/2-associated cancer syndrome: A meta-analysis and case report.

    PubMed

    de Jonge, M M; Mooyaart, A L; Vreeswijk, M P G; de Kroon, C D; van Wezel, T; van Asperen, C J; Smit, V T H B M; Dekkers, O M; Bosse, T

    2017-02-01

    Uterine serous carcinoma (USC) shows greater morphological, clinical and molecular similarities to high-grade ovarian tubal serous carcinoma than to other types of endometrial cancer. As high-grade ovarian tubal serous carcinoma is known to be associated with BRCA1/2 pathogenic germline mutations (PMs), we aimed to explore whether USC is also a constituent of hereditary breast and ovarian cancer syndrome. Pubmed, EMBASE and Web of Science were searched in July 2016 for articles assessing the association between USC and germline BRCA1/2-PMs. Pooled analysis and comparisons were performed using a random effects logistic model, stratifying for ethnicity (Ashkenazi versus non-Ashkenazi). In addition, tumour tissue from an USC case with a hereditary BRCA1-PM was analysed for loss of heterozygosity at the BRCA1 locus and was functionally analysed for homologous recombination proficiency. The search yielded 1893 citations, 10 studies were included describing 345 USC patients. For Ashkenazi Jews, the pooled odds ratio of having a germline BRCA1/2-PM was increased in USC patients compared with the general Ashkenazi population: odds ratio 5.4 (95%confidence interval: 2.2-13.1). In the patient with USC, we identified the known germline BRCA1-PM in the tumour DNA. Furthermore, we showed both loss of heterozygosity of the wild-type allele and a deficiency of homologous recombination. This study suggests that USC may be an overlooked component of BRCA1/2-associated hereditary breast and ovarian cancer syndrome. Screening for germline BRCA1/2-PMs should be considered in patients diagnosed with USC, especially in cases with a positive first-degree family history for breast and/or ovarian cancer. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis.

    PubMed

    Chen, Chun-Yuan; Rao, Shan-Shan; Ren, Lu; Hu, Xiong-Ke; Tan, Yi-Juan; Hu, Yin; Luo, Juan; Liu, Yi-Wei; Yin, Hao; Huang, Jie; Cao, Jia; Wang, Zhen-Xing; Liu, Zheng-Zhao; Liu, Hao-Ming; Tang, Si-Yuan; Xu, Ran; Xie, Hui

    2018-01-01

    Chronic non-healing wounds represent one of the most common complications of diabetes and need advanced treatment strategies. Exosomes are key mediators of cell paracrine action and can be directly utilized as therapeutic agents for tissue repair and regeneration. Here, we explored the effects of exosomes from human urine-derived stem cells (USC-Exos) on diabetic wound healing and the underlying mechanism. Methods: USCs were characterized by flow cytometry and multipotent differentiation potential analyses. USC-Exos were isolated from the conditioned media of USCs and identified by transmission electron microscopy and flow cytometry. A series of functional assays in vitro were performed to assess the effects of USC-Exos on the activities of wound healing-related cells. Protein profiles in USC-Exos and USCs were examined to screen the candidate molecules that mediate USC-Exos function. The effects of USC-Exos on wound healing in streptozotocin-induced diabetic mice were tested by measuring wound closure rates, histological and immunofluorescence analyses. Meanwhile, the role of the candidate protein in USC-Exos-induced regulation of angiogenic activities of endothelial cells and diabetic wound healing was assessed. Results: USCs were positive for CD29, CD44, CD73 and CD90, but negative for CD34 and CD45. USCs were able to differentiate into osteoblasts, adipocytes and chondrocytes. USC-Exos exhibited a cup- or sphere-shaped morphology with a mean diameter of 51.57 ± 2.93 nm and positive for CD63 and TSG101. USC-Exos could augment the functional properties of wound healing-related cells including the angiogenic activities of endothelial cells. USC-Exos were enriched in the proteins that are involved in regulation of wound healing-related biological processes. Particularly, a pro-angiogenic protein called deleted in malignant brain tumors 1 (DMBT1) was highly expressed in USC-Exos. Further functional assays showed that DMBT1 protein was required for USC-Exos-induced promotion of angiogenic responses of cultured endothelial cells, as well as angiogenesis and wound healing in diabetic mice. Conclusion: Our findings suggest that USC-Exos may represent a promising strategy for diabetic soft tissue wound healing by promoting angiogenesis via transferring DMBT1 protein.

  17. 78 FR 68042 - Petition for Waiver and Notice of Granting the Application for Interim Waiver of Indesit Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ..., Part B of the Energy Policy and Conservation Act of 1975 (EPCA), Public Law 94-163 (42 U.S.C. 6291-6309... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy [Case No. CD-009] Petition... Residential Clothes Dryer Test Procedure AGENCY: Office of Energy Efficiency and Renewable Energy, Department...

  18. 1999 Federal Radionavigation Plan

    DOT National Transportation Integrated Search

    2000-01-28

    The Federal Radionavigation Plan (FRP) is published in accordance with 10 U.S.C. 2281(c) and delineates policies and plans for radionavigation services provided by the U.S. Government to ensure efficient use of resources and full protection of nation...

  19. 75 FR 52383 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Order Approving Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... material: principal and interest payment delinquencies; non- payment related defaults; unscheduled draws on... considered the proposed rule's impact on efficiency, competition and capital formation. 15 U.S.C. 78c(f). \\13...

  20. Iron-Air Rechargeable Battery: A Robust and Inexpensive Iron-Air Rechargeable Battery for Grid-Scale Energy Storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2010-10-01

    GRIDS Project: USC is developing an iron-air rechargeable battery for large-scale energy storage that could help integrate renewable energy sources into the electric grid. Iron-air batteries have the potential to store large amounts of energy at low cost—iron is inexpensive and abundant, while oxygen is freely obtained from the air we breathe. However, current iron-air battery technologies have suffered from low efficiency and short life spans. USC is working to dramatically increase the efficiency of the battery by placing chemical additives on the battery’s iron-based electrode and restructuring the catalysts at the molecular level on the battery’s air-based electrode. Thismore » can help the battery resist degradation and increase life span. The goal of the project is to develop a prototype iron-air battery at significantly cost lower than today’s best commercial batteries.« less

  1. 48 CFR 23.702 - Authorities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Contracting for Environmentally Preferable Products and Services 23.702 Authorities. (a) Resource Conservation and Recovery Act (RCRA) (42 U.S.C. 6901, et seq.). (b) National Energy...

  2. 48 CFR 23.702 - Authorities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Contracting for Environmentally Preferable Products and Services 23.702 Authorities. (a) Resource Conservation and Recovery Act (RCRA) (42 U.S.C. 6901, et seq.). (b) National Energy...

  3. 48 CFR 23.702 - Authorities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Contracting for Environmentally Preferable Products and Services 23.702 Authorities. (a) Resource Conservation and Recovery Act (RCRA) (42 U.S.C. 6901, et seq.). (b) National Energy...

  4. State transportation improvement program

    DOT National Transportation Integrated Search

    1996-07-01

    In accordance with 23 U.S.C. Section 135 as amended by the Intermodal Surface Transportation Efficiency Act of 1991 (ISTEA), all highway, bikeway, and transit projects in the state funded under Title 23 and the Federal Transit Act must be included in...

  5. 16 CFR 305.1 - Scope of the regulations in this part.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Act, 42 U.S.C. 6295; (b) Including in printed matter displayed or distributed at the point of sale of..., energy efficiency, or energy cost; and (d) Making representations, in writing or in broadcast advertising...

  6. Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis

    PubMed Central

    Chen, Chun-Yuan; Rao, Shan-Shan; Ren, Lu; Hu, Xiong-Ke; Tan, Yi-Juan; Hu, Yin; Luo, Juan; Liu, Yi-Wei; Yin, Hao; Huang, Jie; Cao, Jia; Wang, Zhen-Xing; Liu, Zheng-Zhao; Liu, Hao-Ming; Tang, Si-Yuan; Xu, Ran; Xie, Hui

    2018-01-01

    Chronic non-healing wounds represent one of the most common complications of diabetes and need advanced treatment strategies. Exosomes are key mediators of cell paracrine action and can be directly utilized as therapeutic agents for tissue repair and regeneration. Here, we explored the effects of exosomes from human urine-derived stem cells (USC-Exos) on diabetic wound healing and the underlying mechanism. Methods: USCs were characterized by flow cytometry and multipotent differentiation potential analyses. USC-Exos were isolated from the conditioned media of USCs and identified by transmission electron microscopy and flow cytometry. A series of functional assays in vitro were performed to assess the effects of USC-Exos on the activities of wound healing-related cells. Protein profiles in USC-Exos and USCs were examined to screen the candidate molecules that mediate USC-Exos function. The effects of USC-Exos on wound healing in streptozotocin-induced diabetic mice were tested by measuring wound closure rates, histological and immunofluorescence analyses. Meanwhile, the role of the candidate protein in USC-Exos-induced regulation of angiogenic activities of endothelial cells and diabetic wound healing was assessed. Results: USCs were positive for CD29, CD44, CD73 and CD90, but negative for CD34 and CD45. USCs were able to differentiate into osteoblasts, adipocytes and chondrocytes. USC-Exos exhibited a cup- or sphere-shaped morphology with a mean diameter of 51.57 ± 2.93 nm and positive for CD63 and TSG101. USC-Exos could augment the functional properties of wound healing-related cells including the angiogenic activities of endothelial cells. USC-Exos were enriched in the proteins that are involved in regulation of wound healing-related biological processes. Particularly, a pro-angiogenic protein called deleted in malignant brain tumors 1 (DMBT1) was highly expressed in USC-Exos. Further functional assays showed that DMBT1 protein was required for USC-Exos-induced promotion of angiogenic responses of cultured endothelial cells, as well as angiogenesis and wound healing in diabetic mice. Conclusion: Our findings suggest that USC-Exos may represent a promising strategy for diabetic soft tissue wound healing by promoting angiogenesis via transferring DMBT1 protein. PMID:29556344

  7. USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

    PubMed

    Toth, Karoly; Spencer, Jacqueline F; Ying, Baoling; Tollefson, Ann E; Hartline, Caroll B; Richard, Eric T; Fan, Jiajun; Lyu, Jinglei; Kashemirov, Boris A; Harteg, Cheryl; Reyna, Dawn; Lipka, Elke; Prichard, Mark N; McKenna, Charles E; Wold, William S M

    2018-05-01

    Human adenoviruses (AdV) cause generally mild infections of the respiratory and GI tracts as well as some other tissues. However, AdV can cause serious infection in severely immunosuppressed individuals, especially pediatric patients undergoing allogeneic hematopoietic stem cell transplantation, where mortality rates are up to 80% with disseminated disease. Despite the seriousness of AdV disease, there are no drugs approved specifically to treat AdV infections. We report here that USC-087, an N-alkyl tyrosinamide phosphonate ester prodrug of HPMPA, the adenine analog of cidofovir, is highly effective against multiple AdV types in cell culture. USC-087 is also effective against AdV-C6 in our immunosuppressed permissive Syrian hamster model. In this model, hamsters are immunosuppressed by treatment with high dose cyclophosphamide. Injection of AdV-C6 (or AdV-C5) intravenously leads to a disseminated infection that resembles the disease seen in humans, including death. We have tested the efficacy of orally-administered USC-087 against the median lethal dose of intravenously administered AdV-C6. USC-087 completely prevented or significantly decreased mortality when administered up to 4 days post challenge. USC-087 also prevented or significantly decreased liver damage caused by AdV-C6 infection, and suppressed virus replication even when administered 4 days post challenge. These results imply that USC-087 is a promising candidate for drug development against HAdV infections. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression.

    PubMed

    Black, Jonathan; Menderes, Gulden; Bellone, Stefania; Schwab, Carlton L; Bonazzoli, Elena; Ferrari, Francesca; Predolini, Federica; De Haydu, Christopher; Cocco, Emiliano; Buza, Natalia; Hui, Pei; Wong, Serena; Lopez, Salvatore; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Litkouhi, Babak; Schwartz, Peter E; Goedings, Peter; Beusker, Patrick H; van der Lee, Miranda M C; Timmers, C Marco; Dokter, Wim H A; Santin, Alessandro D

    2016-08-01

    Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer. Up to 35% of USC may overexpress the HER2/neu oncogene at strong (i.e., 3+) levels by IHC while an additional 40% to 50% express HER2/neu at moderate (2+) or low (1+) levels. We investigated the efficacy of SYD985, (Synthon Biopharmaceuticals), a novel HER2-targeting antibody-drug conjugate (ADC) composed of the mAb trastuzumab linked to a highly potent DNA-alkylating agent (i.e., duocarmycin) in USC. We also compared the antitumor activity of SYD985 in head-to-head experiments to trastuzumab emtansine (T-DM1), a FDA-approved ADC, against multiple primary USC cell lines expressing different levels of HER2/neu in in vitro and in vivo experiments. Using antibody-dependent cellular cytotoxicity (ADCC), proliferation, viability, and bystander killing assays as well as propidium iodide-based flow cytometry assays and multiple in vivo USC mouse xenograft models, we demonstrate for the first time that SYD985 is a novel ADC with activity against USC with strong (3+) as well as low to moderate (i.e., 1+/2+) HER2/neu expression. SYD985 is 10- to 70-fold more potent than T-DM1 in comparative experiments and, unlike T-DM1, it is active against USC demonstrating moderate/low or heterogeneous HER2/neu expression. Clinical studies with SYD985 in patients harboring chemotherapy-resistant USC with low, moderate, and high HER2 expression are warranted. Mol Cancer Ther; 15(8); 1900-9. ©2016 AACR. ©2016 American Association for Cancer Research.

  9. 48 CFR 23.500 - Scope of subpart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.500 Scope of subpart. This subpart implements 41 U.S.C. chapter 81, Drug-Free Workplace. [79 FR 24208, Apr. 29, 2014] ...

  10. Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.

    PubMed

    Groeneweg, Jolijn W; Hall, Tracilyn R; Zhang, Ling; Kim, Minji; Byron, Virginia F; Tambouret, Rosemary; Sathayanrayanan, Sriram; Foster, Rosemary; Rueda, Bo R; Growdon, Whitfield B

    2014-06-01

    Uterine serous carcinoma (USC) represents an aggressive subtype of endometrial cancer. We sought to understand Notch pathway activity in USC and determine if pathway inhibition has anti-tumor activity. Patient USC tissue blocks were obtained and used to correlate clinical outcomes with Notch1 expression. Three established USC cell lines were treated with gamma-secretase inhibitor (GSI) in vitro. Mice harboring cell line derived or patient derived USC xenografts (PDXs) were treated with vehicle, GSI, paclitaxel and carboplatin (P/C), or combination GSI and P/C. Levels of cleaved Notch1 protein and Hes1 mRNA were determined in GSI treated samples. Statistical analysis was performed using the Wilcoxon rank sum and Kaplan-Meier methods. High nuclear Notch1 protein expression was observed in 58% of USC samples with no correlation with overall survival. GSI induced dose-dependent reductions in cell number and decreased levels of cleaved Notch1 protein and Hes1 mRNA in vitro. Treatment of mice with GSI led to decreased Hes1 mRNA expression in USC xenografts. In addition, GSI impeded tumor growth of cell line xenografts as well as UT1 USC PDXs. When GSI and P/C were combined, synergistic anti-tumor activity was observed in UT1 xenografts. Notch1 is expressed in a large subset of USC. GSI-mediated Notch pathway inhibition led to both reduced cell numbers in vitro and decreased tumor growth of USC some xenograft models. When combined with conventional chemotherapy, GSI augmented anti-tumor activity in one USC PDX line suggesting that targeting of the Notch signaling pathway is a potential therapeutic strategy for future investigation. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. 33 CFR 148.737 - What environmental statutes must an applicant follow?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (ESA), Pub. L. 93-205, 16 U.S.C. 1531, et. seq.; Energy Efficiency and Water Conservation at Federal... Agencies to Protect Migratory Birds, E.O. 13186, 66 FR 3853; Safe Drinking Water Act (SDWA), Pub. L. 93-523...

  12. 33 CFR 148.737 - What environmental statutes must an applicant follow?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Species Act of 1973 (ESA), Pub. L. 93-205, 16 U.S.C. 1531, et. seq.; Energy Efficiency and Water... Agencies to Protect Migratory Birds, E.O. 13186, 66 FR 3853; Safe Drinking Water Act (SDWA), Pub. L. 93-523...

  13. Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endometrioid adenocarcinoma.

    PubMed

    Mhawech-Fauceglia, Paulette; Wang, Dan; Kesterson, Joshua; Syriac, Susanna; Clark, Kimberly; Frederick, Peter J; Lele, Shashikant; Liu, Song

    2011-03-23

    Endometrial cancer is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine serous carcinoma (USC) has outcomes similar to early stage high grade endometrioid adenocarcinoma (EAC-G3) than to early stage low grade endometrioid adenocarcinoma (EAC-G1). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n = 11) relative to stage I EAC-G3 (n = 11) and stage I EAC-G1 (n = 11), respectively. We found that the expression difference between USC and EAC-G3, as measured by the number of differentially expressed genes (DEGs), is consistently less than that found between USC and EAC-G1. Pathway enrichment analyses suggested that DEGs specific to USC vs. EAC-G3 are enriched for genes involved in signaling transduction, while DEGs specific to USC vs. EAC-G1 are enriched for genes involved in cell cycle. Gene expression differences for selected DEGs are confirmed by quantitative RT-PCR with a high validation rate. This data, although preliminary, indicates that stage I USC is genetically similar to stage I EAC-G3 compared to stage I EAC-G1. DEGs identified from this study might provide an insight in to the potential mechanisms that influence the clinical outcome differences between endometrial cancer subtypes. They might also have potential prognostic and therapeutic impacts on patients diagnosed with uterine cancer.

  14. The effect of the Family Health Strategy on usual source of care in Brazil: data from the 2013 National Health Survey (PNS 2013).

    PubMed

    Dourado, Inês; Medina, Maria Guadalupe; Aquino, Rosana

    2016-11-17

    A usual source of care (USC) has been conceptualized as having a health provider or place available for patients to consult when sick or in need of medical care. Having a USC is a means to achieve longitudinality of care with Primary Health Care (PHC) providers. Brazil has made enormous progress in PHC and thus provides an important opportunity to investigate USC in a middle-income country context. This study uses data from a nationally representative household survey, the 2013 National Health Survey (n = 62,986), to describe the prevalence of having a USC in Brazil and to investigate to what extent the Family Health Strategy (FHS) has contributed to USC prevalence. Analyses include descriptive, bivariate and multivariable Poisson regression. Show very high rates of people reporting any type of USC (74.4 %) and more than one third reporting PHC as their USC. Household enrolment in the FHS was positively associated with having any USC (PR:1.09; 95 % CI: 1.07-1.12) and a stronger association with having PHC as the regular source of care (PR:1.63;95 % CI:1.54-1.73). FHS enrolment was negatively associated with reporting emergency/urgent care facilities as one's USC (PR: 0.67; 95 % CI: 0.59-0.76). The association between the more consolidated FHS with having a USC was strongest in the poorest regions of the country (North, Northeast and Central-West). Having PHC as one's USC showed a positive dose-response relationship with the FHS in all regions, especially in the Central-West. Our results have important implications for the health care model in Brazil and in other countries, especially those seeking to base their national health systems more strongly on primary health care. The study suggests expanding primary health care can increase the establishment of a USC which can help assure better monitoring of chronic conditions and attention to patient needs.

  15. 48 CFR 23.702 - Authorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Executive Order 13148 of April 21, 2000, Greening the Government through Leadership in Environmental Management. (e) Executive Order 13101 of September 14, 1998, Greening the Government through Waste Prevention... through Efficient Energy Management. (g) Farm Security and Rural Investment Act of 2002 (FSRIA) (7 U.S.C...

  16. Comparative analysis of gas and coal-fired power generation in ultra-low emission condition using life cycle assessment (LCA)

    NASA Astrophysics Data System (ADS)

    Yin, Libao; Liao, Yanfen; Liu, Guicai; Liu, Zhichao; Yu, Zhaosheng; Guo, Shaode; Ma, Xiaoqian

    2017-05-01

    Energy consumption and pollutant emission of natural gas combined cycle power-generation (NGCC), liquefied natural gas combined cycle power-generation (LNGCC), natural gas combined heat and power generation (CHP) and ultra-supercritical power generation with ultra-low gas emission (USC) were analyzed using life cycle assessment method, pointing out the development opportunity and superiority of gas power generation in the period of coal-fired unit ultra-low emission transformation. The results show that CO2 emission followed the order: USC>LNGCC>NGCC>CHP the resource depletion coefficient of coal-fired power generation was lower than that of gas power generation, and the coal-fired power generation should be the main part of power generation in China; based on sensitivity analysis, improving the generating efficiency or shortening the transportation distance could effectively improve energy saving and emission reduction, especially for the coal-fired units, and improving the generating efficiency had a great significance for achieving the ultra-low gas emission.

  17. Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo.

    PubMed

    Schwab, C L; Bellone, S; English, D P; Roque, D M; Lopez, S; Cocco, E; Nicoletti, R; Bortolomai, I; Bonazzoli, E; Ratner, E; Silasi, D-A; Azodi, M; Schwartz, P E; Rutherford, T J; Santin, A D

    2014-10-28

    Uterine serous carcinomas (USCs) are an aggressive form of uterine cancer that may rely on HER2/neu amplification as a driver of proliferation. The objective of this paper is to assess the sensitivity of USC cell lines with and without HER2/neu gene amplification to afatinib, an irreversible ErbB tyrosine kinase inhibitor, and to test the efficacy of afatinib in the treatment of HER2-amplified USC xenografts. Eight of fifteen primary USC cell lines (four with HER2 amplification and four without) demonstrating similar in vitro growth rates were treated with scalar concentrations of afatinib. Effects on cell growth, signalling and cell cycle distribution were determined by flow cytometry assays. Mice harbouring xenografts of HER2/neu-amplified USC were treated with afatinib by gavage to determine the effect on tumour growth and overall survival. Primary chemotherapy-resistant USC cell lines harbouring HER2/neu gene amplification were exquisitely sensitive to afatinib exposure (mean ± s.e.m. IC50=0.0056 ± 0.0006 μM) and significantly more sensitive than HER2/neu-non-amplified USC cell lines (mean ± s.e.m. IC50=0.563 ± 0.092 μM, P<0.0001). Afatinib exposure resulted in abrogation of cell survival, inhibition of HER2/neu autophosphorylation and S6 transcription factor phosphorylation in HER2/neu overexpressing USC and inhibited the growth of HER2-amplified tumour xenografts improving overall survival (P=0.0017). Afatinib may be highly effective against HER2/neu-amplified chemotherapy-resistant USC. The investigation of afatinib in patients harbouring HER2/neu-amplified USC is warranted.

  18. Quantification of Uncertainty in Extreme Scale Computations (QUEST)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ghanem, Roger

    QUEST was a SciDAC Institute comprising Sandia National Laboratories, Los Alamos National Laboratory, the University of Southern California, the Massachusetts Institute of Technology, the University of Texas at Austin, and Duke University. The mission of QUEST is to: (1) develop a broad class of uncertainty quantification (UQ) methods/tools, and (2) provide UQ expertise and software to other SciDAC projects, thereby enabling/guiding their UQ activities. The USC effort centered on the development of reduced models and efficient algorithms for implementing various components of the UQ pipeline. USC personnel were responsible for the development of adaptive bases, adaptive quadrature, and reduced modelsmore » to be used in estimation and inference.« less

  19. USC-HN2, A NEW MODEL CELL LINE FOR RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA WITH IMMUNOSUPPRESSIVE CHARACTERISTICS

    PubMed Central

    Russell, Sarah M; Lechner, Melissa G; Gong, Lucy; Megiel, Carolina; Liebertz, Daniel J.; Masood, Rizwan; Correa, Adrian J; Han, Jing; Puri, Raj K; Sinha, Uttam K; Epstein, Alan L

    2011-01-01

    Objectives Head and neck squamous cell carcinomas (HNSCC) are common and aggressive tumors that have not seen an improvement in survival rates in decades. These tumors are believed to evade the immune system through a variety of mechanisms and are therefore highly immune modulatory. In order to elucidate their interaction with the immune system and develop new therapies targeting immune escape, new pre-clinical models are needed. Materials and Methods A novel human cell line, USC-HN2, was established from a patient biopsy specimen of invasive, recurrent buccal HNSCC and characterized by morphology, heterotransplantation, cytogenetics, phenotype, gene expression and immune modulation studies and compared to a similar HNSCC cell line; SCCL-MT1. Results and Conclusion Characterization studies confirmed the HNSCC origin of USC-HN2 and demonstrated a phenotype similar to the original tumor and typical of aggressive oral cavity HNSCC (EGFR+CD44v6+FABP5+Keratin+ and HPV−). Gene and protein expression studies revealed USC-HN2 to have highly immune-modulatory cytokine production (IL-1β, IL-6, IL-8, GM-CSF, and VEGF) and strong regulatory T and myeloid derived suppressor cell (MDSC) induction capacity in vitro. Of note, both USC-HN2 and SCCL-MT1 were found to have a more robust cytokine profile and MDSC induction capacity when compared to 7 previously established HNSCC cell lines. Additionally, microarray gene expression profiling of both cell lines demonstrate up-regulation of antigen presenting genes. Because USC-HN2 is therefore highly immunogenic, it also induces strong immune suppression to evade immunologic destruction. Based upon these results, both cell lines provide an excellent model for the development of new suppressor cell-targeted immunotherapies. PMID:21719345

  20. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics.

    PubMed

    Russell, Sarah M; Lechner, Melissa G; Gong, Lucy; Megiel, Carolina; Liebertz, Daniel J; Masood, Rizwan; Correa, Adrian J; Han, Jing; Puri, Raj K; Sinha, Uttam K; Epstein, Alan L

    2011-09-01

    Head and neck squamous cell carcinomas (HNSCC) are common and aggressive tumors that have not seen an improvement in survival rates in decades. These tumors are believed to evade the immune system through a variety of mechanisms and are therefore highly immune modulatory. In order to elucidate their interaction with the immune system and develop new therapies targeting immune escape, new pre-clinical models are needed. A novel human cell line, USC-HN2, was established from a patient biopsy specimen of invasive, recurrent buccal HNSCC and characterized by morphology, heterotransplantation, cytogenetics, phenotype, gene expression, and immune modulation studies and compared to a similar HNSCC cell line; SCCL-MT1. Characterization studies confirmed the HNSCC origin of USC-HN2 and demonstrated a phenotype similar to the original tumor and typical of aggressive oral cavity HNSCC (EGFR(+)CD44v6(+)FABP5(+)Keratin(+) and HPV(-)). Gene and protein expression studies revealed USC-HN2 to have highly immune-modulatory cytokine production (IL-1β, IL-6, IL-8, GM-CSF, and VEGF) and strong regulatory T and myeloid derived suppressor cell (MDSC) induction capacity in vitro. Of note, both USC-HN2 and SCCL-MT1 were found to have a more robust cytokine profile and MDSC induction capacity when compared to seven previously established HNSCC cell lines. Additionally, microarray gene expression profiling of both cell lines demonstrate up-regulation of antigen presenting genes. Because USC-HN2 is therefore highly immunogenic, it also induces strong immune suppression to evade immunologic destruction. Based upon these results, both cell lines provide an excellent model for the development of new suppressor cell-targeted immunotherapies. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy.

    PubMed

    Bellone, S; Roque, D; Cocco, E; Gasparrini, S; Bortolomai, I; Buza, N; Abu-Khalaf, M; Silasi, D-A; Ratner, E; Azodi, M; Schwartz, P E; Rutherford, T J; Pecorelli, S; Santin, A D

    2012-04-24

    We evaluated the expression of CD46, CD55 and CD59 membrane-bound complement-regulatory proteins (mCRPs) in primary uterine serous carcinoma (USC) and the ability of small interfering RNA (siRNA) against these mCRPs to sensitise USC to complement-dependent cytotoxicity (CDC) and antibody (trastuzumab)-dependent cellular cytotoxicity (ADCC) in vitro. Membrane-bound complement-regulatory proteins expression was evaluated using real-time PCR (RT-PCR) and flow cytometry, whereas Her2/neu expression and c-erbB2 gene amplification were assessed using immunohistochemistry, flow cytometry and fluorescent in-situ hybridisation. The biological effect of siRNA-mediated knockdown of mCRPs on HER2/neu-overexpressing USC cell lines was evaluated in CDC and ADCC 4-h chromium-release assays. High expression of mCRPs was found in USC cell lines when compared with normal endometrial cells (P<0.05). RT-PCR and FACS analyses demonstrated that anti-mCRP siRNAs were effective in reducing CD46, CD55 and CD59 expression on USC (P<0.05). Baseline complement-dependent cytotoxicity (CDC) against USC cell lines was low (mean ± s.e.m.=6.8 ± 0.9%) but significantly increased upon CD55 and CD59 knockdown (11.6 ± 0.8% and 10.7 ± 0.9%, respectively, P<0.05). Importantly, in the absence of complement, both CD55 and CD59, but not CD46, knockdowns significantly augmented ADCC against USC overexpressing Her2/neu. Uterine serous carcinoma express high levels of the mCRPs CD46, CD55 and CD59. Small interfering RNA inhibition of CD55 and CD59, but not CD46, sensitises USC to both CDC and ADCC in vitro, and if specifically targeted to tumour cells, may significantly increase trastuzumab-mediated therapeutic effect in vivo.

  2. Gene Expression Profiles in Stage I Uterine Serous Carcinoma in Comparison to Grade 3 and Grade 1 Stage I Endometrioid Adenocarcinoma

    PubMed Central

    Mhawech-Fauceglia, Paulette; Wang, Dan; Kesterson, Joshua; Syriac, Susanna; Clark, Kimberly; Frederick, Peter J.; Lele, Shashikant; Liu, Song

    2011-01-01

    Background Endometrial cancer is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine serous carcinoma (USC) has outcomes similar to early stage high grade endometrioid adenocarcinoma (EAC-G3) than to early stage low grade endometrioid adenocarcinoma (EAC-G1). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n = 11) relative to stage I EAC-G3 (n = 11) and stage I EAC-G1 (n = 11), respectively. Methodology/Principal Finding We found that the expression difference between USC and EAC-G3, as measured by the number of differentially expressed genes (DEGs), is consistently less than that found between USC and EAC-G1. Pathway enrichment analyses suggested that DEGs specific to USC vs. EAC-G3 are enriched for genes involved in signaling transduction, while DEGs specific to USC vs. EAC-G1 are enriched for genes involved in cell cycle. Gene expression differences for selected DEGs are confirmed by quantitative RT-PCR with a high validation rate. Conclusion This data, although preliminary, indicates that stage I USC is genetically similar to stage I EAC-G3 compared to stage I EAC-G1. DEGs identified from this study might provide an insight in to the potential mechanisms that influence the clinical outcome differences between endometrial cancer subtypes. They might also have potential prognostic and therapeutic impacts on patients diagnosed with uterine cancer. PMID:21448288

  3. 48 CFR 719.273-3 - Incentives for prime contractor participation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The U.S. Agency for International...) Under the Small Business Act, 15 U.S.C. 637(d)(4)(E), USAID is authorized to provide appropriate incentives to encourage subcontracting opportunities for small business consistent with the efficient and...

  4. Creep Strength of Dissimilar Welded Joints Using High B-9Cr Steel for Advanced USC Boiler

    NASA Astrophysics Data System (ADS)

    Tabuchi, Masaaki; Hongo, Hiromichi; Abe, Fujio

    2014-10-01

    The commercialization of a 973 K (700 °C) class pulverized coal power system, advanced ultra-supercritical (A-USC) pressure power generation, is the target of an ongoing research project initiated in Japan in 2008. In the A-USC boiler, Ni or Ni-Fe base alloys are used for high-temperature parts at 923 K to 973 K (650 °C to 700 °C), and advanced high-Cr ferritic steels are planned to be used at temperatures lower than 923 K (650 °C). In the dissimilar welds between Ni base alloys and high-Cr ferritic steels, Type IV failure in the heat-affected zone (HAZ) is a concern. Thus, the high B-9Cr steel developed at the National Institute for Materials Science, which has improved creep strength in weldments, is a candidate material for the Japanese A-USC boiler. In the present study, creep tests were conducted on the dissimilar welded joints between Ni base alloys and high B-9Cr steels. Microstructures and creep damage in the dissimilar welded joints were investigated. In the HAZ of the high B-9Cr steels, fine-grained microstructures were not formed and the grain size of the base metal was retained. Consequently, the creep rupture life of the dissimilar welded joints using high B-9Cr steel was 5 to 10 times longer than that of the conventional 9Cr steel welded joints at 923 K (650 °C).

  5. 7 CFR 1780.57 - Design policies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... et seq.). (c) Energy/environment. Facility design should consider cost effective energy-efficient and... distribution system water losses do not exceed reasonable levels. (g) Conformity with State drinking water... title XIV of the Public Health Service Act (commonly known as the ‘Safe Drinking Water Act’) (42 U.S.C...

  6. 7 CFR 1780.57 - Design policies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... et seq.). (c) Energy/environment. Facility design should consider cost effective energy-efficient and... distribution system water losses do not exceed reasonable levels. (g) Conformity with State drinking water... title XIV of the Public Health Service Act (commonly known as the ‘Safe Drinking Water Act’) (42 U.S.C...

  7. 7 CFR 1780.57 - Design policies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... et seq.). (c) Energy/environment. Facility design should consider cost effective energy-efficient and... distribution system water losses do not exceed reasonable levels. (g) Conformity with State drinking water... title XIV of the Public Health Service Act (commonly known as the ‘Safe Drinking Water Act’) (42 U.S.C...

  8. 7 CFR 1780.57 - Design policies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... et seq.). (c) Energy/environment. Facility design should consider cost effective energy-efficient and... distribution system water losses do not exceed reasonable levels. (g) Conformity with State drinking water... title XIV of the Public Health Service Act (commonly known as the ‘Safe Drinking Water Act’) (42 U.S.C...

  9. 7 CFR 1780.57 - Design policies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... et seq.). (c) Energy/environment. Facility design should consider cost effective energy-efficient and... distribution system water losses do not exceed reasonable levels. (g) Conformity with State drinking water... title XIV of the Public Health Service Act (commonly known as the ‘Safe Drinking Water Act’) (42 U.S.C...

  10. 10 CFR 431.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Definitions. 431.2 Section 431.2 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT... Section 340 of the Act. Act means the Energy Policy and Conservation Act of 1975, as amended, 42 U.S.C...

  11. 10 CFR 501.51 - Prohibitions by order-electing powerplants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 501.51 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS... minimum amount necessary to maintain reliability of operation consistent with reasonable fuel efficiency....); Powerplant and Industrial Fuel Use Act of 1978, Pub. L. 95-620, 92 Stat. 3269 (42 U.S.C. 8301 et seq...

  12. 10 CFR 501.50 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Prohibition Rules and Orders § 501.50... operation consistent with reasonable fuel efficiency in an existing installation unless and until OFE adopts... Act, Pub. L. 95-91, 91 Stat. 565 (42 U.S.C. 7101 et seq.); Powerplant and Industrial Fuel Use Act of...

  13. 46 CFR 501.5 - Functions of the organizational components of the Federal Maritime Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... activities designed to promote economy, efficiency, and effectiveness in the administration of, and to...(8) of the Shipping Act of 1984 (46 U.S.C. 40102(8)), researches their status, and makes... include: Conducting IT management studies and surveys; managing data and voice telecommunications...

  14. 46 CFR 501.5 - Functions of the organizational components of the Federal Maritime Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and recommends policies for activities designed to promote economy, efficiency, and effectiveness in...(8) of the Shipping Act of 1984 (46 U.S.C. 40102(8)), researches their status, and makes... Commission. The Office's functions include: Conducting IT management studies and surveys; managing data and...

  15. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... drawback, as well as for drawback involving the substitution of finished petroleum derivatives (19 U.S.C. 1313(a), (b), (c), (j), or (p)). It is intended to improve administrative efficiency. (b) Format of... Chronological Summary of Exports to the appropriate documentary evidence of exportation (for example, Bill of...

  16. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... drawback, as well as for drawback involving the substitution of finished petroleum derivatives (19 U.S.C. 1313(a), (b), (c), (j), or (p)). It is intended to improve administrative efficiency. (b) Format of... Chronological Summary of Exports to the appropriate documentary evidence of exportation (for example, Bill of...

  17. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... drawback, as well as for drawback involving the substitution of finished petroleum derivatives (19 U.S.C. 1313(a), (b), (c), (j), or (p)). It is intended to improve administrative efficiency. (b) Format of... Chronological Summary of Exports to the appropriate documentary evidence of exportation (for example, Bill of...

  18. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... drawback, as well as for drawback involving the substitution of finished petroleum derivatives (19 U.S.C. 1313(a), (b), (c), (j), or (p)). It is intended to improve administrative efficiency. (b) Format of... Chronological Summary of Exports to the appropriate documentary evidence of exportation (for example, Bill of...

  19. 77 FR 39795 - Notice of Final Federal Agency Actions on the Interstate 395 High Occupancy (HOV) Vehicle Ramp at...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... actions subject to 23 U.S.C. 139(l)(1). A claim seeking judicial review of the Federal agency actions on...: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Limitation on Claims for Judicial Review of... meaning of 23 U.S.C. 139(l)(1). The actions relate to the Interstate 395 High Occupancy Vehicle (HOV) Ramp...

  20. MGH-USC Human Connectome Project Datasets with Ultra-High b-Value Diffusion MRI

    PubMed Central

    Fan, Qiuyun; Witzel, Thomas; Nummenmaa, Aapo; Van Dijk, Koene R.A.; Van Horn, John D.; Drews, Michelle K.; Somerville, Leah H.; Sheridan, Margaret A.; Santillana, Rosario M.; Snyder, Jenna; Hedden, Trey; Shaw, Emily E.; Hollinshead, Marisa O.; Renvall, Ville; Zanzonico, Roberta; Keil, Boris; Cauley, Stephen; Polimeni, Jonathan R.; Tisdall, Dylan; Buckner, Randy L.; Wedeen, Van J.; Wald, Lawrence L.; Toga, Arthur W.; Rosen, Bruce R.

    2015-01-01

    The MGH-USC CONNECTOM MRI scanner housed at the Massachusetts General Hospital (MGH) is a major hardware innovation of the Human Connectome Project (HCP). The 3T CONNECTOM scanner is capable of producing magnetic field gradient of up to 300 mT/m strength for in vivo human brain imaging, which greatly shortens the time spent on diffusion encoding, and decreases the signal loss due to T2 decay. To demonstrate the capability of the novel gradient system, data of healthy adult participants were acquired for this MGH-USC Adult Diffusion Dataset (N=35), minimally preprocessed, and shared through the Laboratory of Neuro Imaging Image Data Archive (LONI IDA) and the WU-Minn Connectome Database (ConnecomeDB). Another purpose of sharing the data is to facilitate methodological studies of diffusion MRI (dMRI) analyses utilizing high diffusion contrast, which perhaps is not easily feasible with standard MR gradient system. In addition, acquisition of the MGH-Harvard-USC Lifespan Dataset is currently underway to include 120 healthy participants ranging from 8 to 90 years old, which will also be shared through LONI IDA and ConnectomeDB. Here we describe the efforts of the MGH-USC HCP consortium in acquiring and sharing the ultra-high b-value diffusion MRI data and provide a report on data preprocessing and access. We conclude with a demonstration of the example data, along with results of standard diffusion analyses, including q-ball Orientation Distribution Function (ODF) reconstruction and tractography. PMID:26364861

  1. 75 FR 66119 - Proposed Information Collection; International Conservation Grant Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ..., great apes, elephants, and many other highly cherished species. The Division of International Conservation administers 11 competitive grant programs funded under the: African Elephant Conservation Act (16 U.S.C. 4201-4245). Asian Elephant Conservation Act of 1997 (16 U.S.C. 4261). Great Apes Conservation...

  2. Having a Physician Rather than a Place as a Usual Source of Care Would Be Better - from 2012 Korea Health Panel Data.

    PubMed

    Kim, Kyeong Min; Jeon, Hyunsoo; Lee, Jae Ho

    2017-01-01

    A usual source of care (USC) in primary care improves health care quality and can result in improved health. However, current research about the type of USC (place only vs. physician with a place) is insufficient as an evidence to support the value of primary care. We analyzed data from the 2012 Korea Health Panel survey of adults aged 18 years or older (n = 11,873) who reported whether having a USC or not to compare the effects by type of USC on medical care use and out-of-pocket costs. Descriptive analysis showed significant differences in the distributions of sociodemographic and health status factors except frequency of outpatient visit by type of USC. Adjusted odds ratios (ORs) of having a physician with a place compared to not having a USC were 4.05 for age 65 ≥ years (vs. < 35 years), 1.33 for females (vs. males), 0.63 for the fifth (highest) quintile (vs. the first) of household income, 1.62 for medical aid (vs. employee) health insurance, and 4.46 for having a chronic disease (vs. not). For those having a physician with a place (vs. only a place) as a USC, adjusted ORs of hospital admission and emergency room (ER) visit were 0.77 and 0.71 with out-of-pocket costs not significantly high. Those having a physician with a place (vs. only a place) as a USC included more patients with chronic diseases, but they had fewer hospital admissions and ER visits. When designing a plan for health care reform in Korea, promoting having a physician rather than a place as a USC would be a better policy.

  3. Having a Physician Rather than a Place as a Usual Source of Care Would Be Better - from 2012 Korea Health Panel Data

    PubMed Central

    2017-01-01

    A usual source of care (USC) in primary care improves health care quality and can result in improved health. However, current research about the type of USC (place only vs. physician with a place) is insufficient as an evidence to support the value of primary care. We analyzed data from the 2012 Korea Health Panel survey of adults aged 18 years or older (n = 11,873) who reported whether having a USC or not to compare the effects by type of USC on medical care use and out-of-pocket costs. Descriptive analysis showed significant differences in the distributions of sociodemographic and health status factors except frequency of outpatient visit by type of USC. Adjusted odds ratios (ORs) of having a physician with a place compared to not having a USC were 4.05 for age 65 ≥ years (vs. < 35 years), 1.33 for females (vs. males), 0.63 for the fifth (highest) quintile (vs. the first) of household income, 1.62 for medical aid (vs. employee) health insurance, and 4.46 for having a chronic disease (vs. not). For those having a physician with a place (vs. only a place) as a USC, adjusted ORs of hospital admission and emergency room (ER) visit were 0.77 and 0.71 with out-of-pocket costs not significantly high. Those having a physician with a place (vs. only a place) as a USC included more patients with chronic diseases, but they had fewer hospital admissions and ER visits. When designing a plan for health care reform in Korea, promoting having a physician rather than a place as a USC would be a better policy. PMID:27914125

  4. Microstructural evolution in advanced boiler materials for ultra-supercritical coal power plants

    NASA Astrophysics Data System (ADS)

    Wu, Quanyan

    The goal of improving the efficiency of pulverized coal powerplants has been pursued for decades. The need for greater efficiency and reduced environmental impact is pushing utilities to ultra supercritical conditions (USC), i.e. steam temperatures approaching 760°C under a stress of 35 MPa. The long-term creep strength and environmental resistance requirements imposed by these conditions are clearly beyond the capacity of the currently used ferritic steels and other conventional alloys. As part of a large DOE-funded consortium, new and existing materials based on advanced austenitic stainless steels and nickel base superalloys are being evaluated for these very demanding applications. In the present work, the nickel base superalloys of Inconel 617, CCA617, Haynes 230 and Inconel 740, and austenitic alloys Super 304H and HR6W, were evaluated on their microstructural properties over elevated temperature ageing and creep rupture conditions. The materials were aged for different lengths of time at temperatures relevant to USC applications, i.e., in the range from 700 to 800°C. The precipitation behaviors, namely of the gamma', carbides and eta phase in some conditions in nickel base superalloys, carbides in Haynes 230, Cu-rich precipitates in Super 304H and Laves phase particles in HR6W, were studied in detail using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and related analytical techniques. Particular attention has been given on the structure, morphology and compositional distinctiveness of various phases (including gamma, gamma', carbides, secondary phase precipitates, and other types of particles) and their nature, dislocation structures and other types of defects. The results were presented and discussed in light of associated changes in microhardness in the cases of aged samples, and in close reference to mechanical testing (including tensile and creep rupture tests) wherever available. Several mechanical strengthening mechanisms were proposed and the results were calculated using the corresponding modeling equations. They were then compared to the mechanical properties recorded separately. These findings documented the microstructural responses of candidate alloys for USC applications from sample treatments that were related to the conditions of that from USC, and thus provided inputs to both assessment and predictions of mechanical behaviors of these alloys under USC service conditions.

  5. Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance.

    PubMed

    Carvajal-Hausdorf, Daniel E; Schalper, Kurt A; Bai, Yalai; Black, Jonathan; Santin, Alessandro D; Rimm, David L

    2017-04-01

    HER2 overexpression/amplification is identified in up to 40% of uterine serous carcinomas (USC) and 10% of ovarian serous carcinomas (OSC). However, clinical trials using various HER2-targeted agents failed to show significant responses. FDA-approved HER2 assays target only the protein's intracellular domain (ICD) and not the extracellular domain (ECD). Previous quantitative studies in breast cancer by our group have shown that ICD of HER2 is expressed in some cases that do not express the HER2 ECD. We measured HER2 ICD and ECD in USC and OSC samples, and determined their relationship with clinico-pathologic characteristics and survival. We measured HER2 ICD and ECD levels in 2 cohorts of USC and OSC comprising 102 and 175 patients, respectively. HER2 antibodies targeting ICD (CB11) and ECD (SP3) were validated and standardized using the AQUA® method of quantitative immunofluorescence (QIF) and a previously reported HER2 standardization tissue microarray (TMA). Objective, population-based cut-points were used to stratify patients according to HER2 ICD/ECD status. In USC, 8% of patients with high HER2 ICD had low ECD levels (6/75 patients). In OSC, 42% of patients with high HER2 ICD had low ECD levels (29/69 patients). HER2 ICD/ECD status in USC and OSC was not significantly associated with major clinico-pathological features or survival. Using objective, domain-specific HER2 measurement, 8% of USC and 42% of OSC patients with high HER2 ICD levels do not show uniform overexpression of the ECD. This may be related to the presence of p95 HER2, an oncogenic fragment generated by full protein cleavage or alternative initiation of translation. These observations raise the possibility that USC/OSCs expressing low ECD despite being HER2-positive by ICD measurement, may benefit from therapies directed against the intracellular domain (e.g. lapatinib or afatinib) alone or in combination with extracellular domain-directed drugs (e.g. trastuzumab, pertuzumab, T-DM1). Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. 77 FR 37324 - Safety Zone; Major Motion Picture Filming, Cape Fear River; Wilmington, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... vessels from a portion of the Cape Fear River due to the filming of a movie involving high speed boat..., given the high risks of injury and damage that will be created during the filming of the movie, a delay...; 46 U.S.C. Chapter 701, 3306, 3703; 50 U.S.C. 191, 195; 33 CFR 1.05-1, 6.04-1, 6.04-6, 160.5; Pub. L...

  7. Self-Renewal and Differentiation Capacity of Urine-Derived Stem Cells after Urine Preservation for 24 Hours

    PubMed Central

    Shi, Yingai; Bharadwaj, Shantaram; Leng, Xiaoyan; Zhou, Xiaobo; Liu, Hong; Atala, Anthony; Zhang, Yuanyuan

    2013-01-01

    Despite successful approaches to preserve organs, tissues, and isolated cells, the maintenance of stem cell viability and function in body fluids during storage for cell distribution and transportation remains unexplored. The aim of this study was to characterize urine-derived stem cells (USCs) after optimal preservation of urine specimens for up to 24 hours. A total of 415 urine specimens were collected from 12 healthy men (age range 20–54 years old). About 6×104 cells shed off from the urinary tract system in 24 hours. At least 100 USC clones were obtained from the stored urine specimens after 24 hours and maintained similar biological features to fresh USCs. The stored USCs had a “rice grain” shape in primary culture, and expressed mesenchymal stem cell surface markers, high telomerase activity, and normal karyotypes. Importantly, the preserved cells retained bipotent differentiation capacity. Differentiated USCs expressed myogenic specific proteins and contractile function when exposed to myogenic differentiation medium, and they expressed urothelial cell-specific markers and barrier function when exposed to urothelial differentiation medium. These data demonstrated that up to 75% of fresh USCs can be safely persevered in urine for 24 hours and that these cells stored in urine retain their original stem cell properties, indicating that preserved USCs could be available for potential use in cell-based therapy or clinical diagnosis. PMID:23349776

  8. Securities and Exchange Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... USC 78n(d)(4); 15 USC 78o(c)(3); 15 USC 78o(c)(6); 15 USC 78q-1(a); 15 USC 78q- 1(d)(1); 15 USC 78w(a...: 15 USC 78b; 15 USC 78c(b); 15 USC 78j; 15 USC 78o(c); 15 USC 78o-4; 15 USC 78q; 15 USC 78w(a)(1... official business days between the hours of 10:00 a.m. and 3:00 p.m. All comments received will be posted...

  9. Women's self-efficacy perceptions in mathematics and science: Investigating USC-MESA students

    NASA Astrophysics Data System (ADS)

    Hong, Rebecca Cheng-Shun

    This study is an investigation into female high school seniors in the USC-MESA program and how the role of self-efficacy perceptions in mathematics and science relates to their college major choice. Bandura's theory on self-efficacy provides the backdrop for this study. This study is qualitative and takes an ethnographic approach incorporating 23 interviews, 2 focus groups, 49.5 hours of observation, and document analysis. Results show that female high school seniors participating in the USC-MESA program demonstrate a strong self-efficacy perception in mathematics and science through their academic choices and pursuits in high school and beyond. This finding confirms a linear approach in understanding how courses taken in high school contribute to the trajectory of college academic choices. It also challenges the theory of self-efficacy in math and science to examine historically underrepresented populations in the field and the external factors that play a key role in their persistence to pursue STEM fields in college and beyond.

  10. 78 FR 79637 - Energy Conservation Program: Test Procedure for Set-Top Boxes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... Energy Conservation Program: Test Procedure for Set-Top Boxes AGENCY: Office of Energy Efficiency and... Energy (DOE) withdraws a proposed rule published January 23, 2013 to establish a test procedure to... additional types of consumer products as covered products. (42 U.S.C. 6292(a)(20)) DOE may prescribe test...

  11. 16 CFR 305.1 - Scope of the regulations in this part.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OTHER PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Scope... Policy and Conservation Act, 42 U.S.C. 6291, with respect to: (a) Labeling and/or marking the products..., respecting the water use, energy consumption, or energy efficiency of the products, or the cost of water used...

  12. 16 CFR 305.1 - Scope of the regulations in this part.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OTHER PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Scope... Policy and Conservation Act, 42 U.S.C. 6291, with respect to: (a) Labeling and/or marking the products..., respecting the water use, energy consumption, or energy efficiency of the products, or the cost of water used...

  13. 16 CFR 305.1 - Scope of the regulations in this part.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OTHER PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Scope... Policy and Conservation Act, 42 U.S.C. 6291, with respect to: (a) Labeling and/or marking the products..., respecting the water use, energy consumption, or energy efficiency of the products, or the cost of water used...

  14. 75 FR 17078 - Agency Information Collection: Energy Conservation Program: Compliance and Certification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... Certification information collection request for certain 1 through 200 horsepower electric motors covered under... efficiency standards for certain commercial and industrial electric motors. 42 U.S.C. 6316(c) and 10 CFR 431...: Comments must identify the information collection for electric motors and provide the docket number EERE...

  15. Energy and Energy Cost Savings Analysis of the 2015 IECC for Commercial Buildings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Jian; Xie, YuLong; Athalye, Rahul A.

    As required by statute (42 USC 6833), DOE recently issued a determination that ANSI/ASHRAE/IES Standard 90.1-2013 would achieve greater energy efficiency in buildings subject to the code compared to the 2010 edition of the standard. Pacific Northwest National Laboratory (PNNL) conducted an energy savings analysis for Standard 90.1-2013 in support of its determination . While Standard 90.1 is the model energy standard for commercial and multi-family residential buildings over three floors (42 USC 6833), many states have historically adopted the International Energy Conservation Code (IECC) for both residential and commercial buildings. This report provides an assessment as to whether buildingsmore » constructed to the commercial energy efficiency provisions of the 2015 IECC would save energy and energy costs as compared to the 2012 IECC. PNNL also compared the energy performance of the 2015 IECC with the corresponding Standard 90.1-2013. The goal of this analysis is to help states and local jurisdictions make informed decisions regarding model code adoption.« less

  16. MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI.

    PubMed

    Fan, Qiuyun; Witzel, Thomas; Nummenmaa, Aapo; Van Dijk, Koene R A; Van Horn, John D; Drews, Michelle K; Somerville, Leah H; Sheridan, Margaret A; Santillana, Rosario M; Snyder, Jenna; Hedden, Trey; Shaw, Emily E; Hollinshead, Marisa O; Renvall, Ville; Zanzonico, Roberta; Keil, Boris; Cauley, Stephen; Polimeni, Jonathan R; Tisdall, Dylan; Buckner, Randy L; Wedeen, Van J; Wald, Lawrence L; Toga, Arthur W; Rosen, Bruce R

    2016-01-01

    The MGH-USC CONNECTOM MRI scanner housed at the Massachusetts General Hospital (MGH) is a major hardware innovation of the Human Connectome Project (HCP). The 3T CONNECTOM scanner is capable of producing a magnetic field gradient of up to 300 mT/m strength for in vivo human brain imaging, which greatly shortens the time spent on diffusion encoding, and decreases the signal loss due to T2 decay. To demonstrate the capability of the novel gradient system, data of healthy adult participants were acquired for this MGH-USC Adult Diffusion Dataset (N=35), minimally preprocessed, and shared through the Laboratory of Neuro Imaging Image Data Archive (LONI IDA) and the WU-Minn Connectome Database (ConnectomeDB). Another purpose of sharing the data is to facilitate methodological studies of diffusion MRI (dMRI) analyses utilizing high diffusion contrast, which perhaps is not easily feasible with standard MR gradient system. In addition, acquisition of the MGH-Harvard-USC Lifespan Dataset is currently underway to include 120 healthy participants ranging from 8 to 90 years old, which will also be shared through LONI IDA and ConnectomeDB. Here we describe the efforts of the MGH-USC HCP consortium in acquiring and sharing the ultra-high b-value diffusion MRI data and provide a report on data preprocessing and access. We conclude with a demonstration of the example data, along with results of standard diffusion analyses, including q-ball Orientation Distribution Function (ODF) reconstruction and tractography. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. NTCP modelling of lung toxicity after SBRT comparing the universal survival curve and the linear quadratic model for fractionation correction.

    PubMed

    Wennberg, Berit M; Baumann, Pia; Gagliardi, Giovanna; Nyman, Jan; Drugge, Ninni; Hoyer, Morten; Traberg, Anders; Nilsson, Kristina; Morhed, Elisabeth; Ekberg, Lars; Wittgren, Lena; Lund, Jo-Åsmund; Levin, Nina; Sederholm, Christer; Lewensohn, Rolf; Lax, Ingmar

    2011-05-01

    In SBRT of lung tumours no established relationship between dose-volume parameters and the incidence of lung toxicity is found. The aim of this study is to compare the LQ model and the universal survival curve (USC) to calculate biologically equivalent doses in SBRT to see if this will improve knowledge on this relationship. Toxicity data on radiation pneumonitis grade 2 or more (RP2+) from 57 patients were used, 10.5% were diagnosed with RP2+. The lung DVHs were corrected for fractionation (LQ and USC) and analysed with the Lyman- Kutcher-Burman (LKB) model. In the LQ-correction α/β = 3 Gy was used and the USC parameters used were: α/β = 3 Gy, D(0) = 1.0 Gy, [Formula: see text] = 10, α = 0.206 Gy(-1) and d(T) = 5.8 Gy. In order to understand the relative contribution of different dose levels to the calculated NTCP the concept of fractional NTCP was used. This might give an insight to the questions of whether "high doses to small volumes" or "low doses to large volumes" are most important for lung toxicity. NTCP analysis with the LKB-model using parameters m = 0.4, D(50) = 30 Gy resulted for the volume dependence parameter (n) with LQ correction n = 0.87 and with USC correction n = 0.71. Using parameters m = 0.3, D(50) = 20 Gy n = 0.93 with LQ correction and n = 0.83 with USC correction. In SBRT of lung tumours, NTCP modelling of lung toxicity comparing models (LQ,USC) for fractionation correction, shows that low dose contribute less and high dose more to the NTCP when using the USC-model. Comparing NTCP modelling of SBRT data and data from breast cancer, lung cancer and whole lung irradiation implies that the response of the lung is treatment specific. More data are however needed in order to have a more reliable modelling.

  18. Experimentally simulating the dynamics of quantum light and matter at ultrastrong coupling using circuit QED (2) - light dynamics and light-matter entanglement -

    NASA Astrophysics Data System (ADS)

    Sagastizabal, R.; Langford, N. K.; Kounalakis, M.; Dickel, C.; Bruno, A.; Luthi, F.; Thoen, D. J.; Endo, A.; Dicarlo, L.

    Light-matter interaction can lead to large photon build-up and hybrid atom-photon entanglement in the ultrastrong coupling (USC) regime, where the coupling strength becomes comparable to the eigenenergies of the system. Accessing the cavity degree of freedom, however, is an outstanding challenge in natural USC systems. In this talk, we directly probe light field dynamics in the USC regime using a digital simulation of the quantum Rabi model in a planar circuit QED chip with a transmon moderately coupled to a resonator. We produce high-accuracy USC light-matter dynamics, using second-order Trotterisation and up to 90 Trotter steps. We probe the average photon number, photon parity and perform Wigner tomography of the simulated field. Finally, we combine tomography of the resonator with qubit measurements to evidence the Schrödinger-cat-like atom-photon entanglement which is a key signature of light-matter dynamics in the USC regime. Funding from the EU FP7 Project ScaleQIT, the ERC Synergy Grant QC-lab, the Netherlands Organization of Scientic Research (NWO), and Microsoft Research.

  19. PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas

    PubMed Central

    Black, Jonathan D; Lopez, Salvatore; Cocco, Emiliano; Bellone, Stefania; Altwerger, Gary; Schwab, Carlton L; English, Diana P; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Santin, Alessandro D

    2015-01-01

    Objectives: We evaluated the role of PIK3CA-mutations as mechanism of resistance to trastuzumab in primary HER2/neu-amplified uterine-serous-carcinoma (USC) cell lines. Methods: Fifteen whole-exome-sequenced USC cell lines were tested for HER2/neu-amplification and PIK3CA-mutations. Four HER2/neu-amplified USC (2-harbouring wild-type-PIK3CA-genes and 2-harbouring oncogenic-PIK3CA-mutations) were evaluated in in vitro dose-titration-proliferation-assays, cell-viability and HER2 and S6-protein-phosphorylation after exposure to trastuzumab. USC harbouring wild-type-PIK3CA were transfected with plasmids encoding oncogenic PIK3CA-mutations (i.e., H1047R/R93Q) and exposed to trastuzumab. Finally, trastuzumab efficacy was tested by using two USC xenograft mouse models. Results: Seven out of fifteen (46%) of the USC cell lines were HER2/neu-amplified by fluorescence in situ hybridisation. Within these tumours four out of seven (57%) were found to harbour oncogenic PIK3CA-mutations vs two out of eight (25%) of the HER2/neu not amplified cell lines (P=0.01). HER2/neu-amplified/PIK3CA-mutated USC were highly resistant to trastuzumab when compared with HER2/neu-amplified/wild-type-PIK3CA cell lines (P=0.02). HER2/neu-amplified/PIK3CA wild-type cell lines transfected with oncogenic PIK3CA-mutations increased their resistance to trastuzumab (P<0.0001). Trastuzumab was effective in reducing tumour growth (P=0.001) and improved survival (P=0.0001) in mouse xenografts harbouring HER2-amplified/PIK3CA wild-type USC but not in HER2-amplified/PIK3CA-mutated tumours. Conclusions: Oncogenic PIK3CA mutations are common in HER2/neu-amplified USC and may constitute a major mechanism of resistance to trastuzumab treatment. PMID:26325104

  20. PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.

    PubMed

    Black, Jonathan D; Lopez, Salvatore; Cocco, Emiliano; Bellone, Stefania; Altwerger, Gary; Schwab, Carlton L; English, Diana P; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Santin, Alessandro D

    2015-09-29

    We evaluated the role of PIK3CA-mutations as mechanism of resistance to trastuzumab in primary HER2/neu-amplified uterine-serous-carcinoma (USC) cell lines. Fifteen whole-exome-sequenced USC cell lines were tested for HER2/neu-amplification and PIK3CA-mutations. Four HER2/neu-amplified USC (2-harbouring wild-type-PIK3CA-genes and 2-harbouring oncogenic-PIK3CA-mutations) were evaluated in in vitro dose-titration-proliferation-assays, cell-viability and HER2 and S6-protein-phosphorylation after exposure to trastuzumab. USC harbouring wild-type-PIK3CA were transfected with plasmids encoding oncogenic PIK3CA-mutations (i.e., H1047R/R93Q) and exposed to trastuzumab. Finally, trastuzumab efficacy was tested by using two USC xenograft mouse models. Seven out of fifteen (46%) of the USC cell lines were HER2/neu-amplified by fluorescence in situ hybridisation. Within these tumours four out of seven (57%) were found to harbour oncogenic PIK3CA-mutations vs two out of eight (25%) of the HER2/neu not amplified cell lines (P=0.01). HER2/neu-amplified/PIK3CA-mutated USC were highly resistant to trastuzumab when compared with HER2/neu-amplified/wild-type-PIK3CA cell lines (P=0.02). HER2/neu-amplified/PIK3CA wild-type cell lines transfected with oncogenic PIK3CA-mutations increased their resistance to trastuzumab (P<0.0001). Trastuzumab was effective in reducing tumour growth (P=0.001) and improved survival (P=0.0001) in mouse xenografts harbouring HER2-amplified/PIK3CA wild-type USC but not in HER2-amplified/PIK3CA-mutated tumours. Oncogenic PIK3CA mutations are common in HER2/neu-amplified USC and may constitute a major mechanism of resistance to trastuzumab treatment.

  1. 41 CFR 102-192.170 - What are GSA's responsibilities in mail management?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... guidance and assistance to Federal agencies to ensure economical and efficient records management. 44 U.S.C. § 2901(2) and (4) (C) define the processing of mail by Federal agencies as part of records management. In... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What are GSA's...

  2. 41 CFR 102-192.170 - What are GSA's responsibilities in mail management?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... guidance and assistance to Federal agencies to ensure economical and efficient records management. 44 U.S.C. § 2901(2) and (4) (C) define the processing of mail by Federal agencies as part of records management. In... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are GSA's...

  3. 77 FR 25522 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... trades with final money calculations on the night of Auction Date, after the Treasury auction results... end of day netting process. However, when Interactive Messaging was implemented in 2000, this... efficiency, competition, and capital formation. See 15 U.S.C. 78c(f). \\9\\ 17 CFR 200.30-3(a)(12). For the...

  4. 3 CFR 13496 - Executive Order 13496 of January 30, 2009. Notification of Employee Rights Under Federal Labor Laws

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...' productivity is enhanced when workers are well informed of their rights under Federal labor laws, including the... are informed of such rights under Federal labor laws facilitates the efficient and economical... collective bargaining agreements as defined in 5 U.S.C. 7103(a)(8) and purchases under the simplified...

  5. 76 FR 20394 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... uniformity regarding decisions to pause trading and continue to reduce the negative impacts of sudden, unanticipated price movements in Circuit Breaker Securities. The Exchange believes that the pilot is working... the proposed rule's impact on efficiency, competition, and capital formation. See 15 U.S.C. 78c(f). At...

  6. 78 FR 54899 - Draft Guidance for Industry on Specification of the Unique Facility Identifier System for Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... 1995 (the PRA) (44 U.S.C. 3501-3520), Federal Agencies must obtain approval from the Office of... collection to OMB for approval. To comply with this requirement, FDA is publishing this notice of the... submission process functions most efficiently and effectively when the information is provided in a...

  7. 75 FR 79873 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Legal Authority: 40 USC 121(c); 10 USC ch 137; 42 USC 2473(c) Abstract: The Civilian Agency Acquisition... REPORTING PROCEDURES Legal Authority: 40 USC 121(c); 10 USC ch 137; 42 USC 2473(c) Abstract: The Civilian... EXECUTIVE COMPENSATION AND FIRST-TIER SUBCONTRACT AWARDS Legal Authority: 40 USC 121(c); 10 USC ch 137; 42...

  8. USC/School Performance Dashboard 2013. A Report from the Center on Educational Governance/University of Southern California

    ERIC Educational Resources Information Center

    Center on Educational Governance, 2013

    2013-01-01

    The USC School Performance Dashboard, now in its seventh year, draws on California school data from 2003-2012 to rate charter schools on academic and financial measures of performance. It also provides an accompanying interactive site at www.uscrossier.org/ceg/. Unlike other school databases, this one assigns values--high, medium, low--to the…

  9. 32 CFR 750.25 - Scope of liability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Scope of liability. 750.25 Section 750.25... Federal Tort Claims Act § 750.25 Scope of liability. (a) Territorial limitations. The FTCA does not apply... 46 U.S.C. 741-752 or 781-790. Claims under the Death on the High Seas Act (46 U.S.C. 761), however...

  10. Two-Year Stability and Change in Access to and Reasons for Lacking a Usual Source of Care Among Working-Age US Adults.

    PubMed

    Stransky, Michelle L

    The objective of this study was to investigate usual source of care (USC) over time. A nationally representative sample of working-age adults in the Medical Expenditure Panel Survey (Panels 16 [2011-2012] and 17 [2012-2013]) was divided into 3 groups based on USC questions asked during 2 waves: (1) those having a USC during both waves (always USC), (2) those not having a USC during either wave (never USC), and (3) those who gained or lost a USC between the 2 waves (changed USC). The study examined the sociodemographic and health characteristics associated with these groups and the main reasons for not having a USC among those who never had a USC and those who changed their USC. Of the 10 792 adults in the analysis, a longitudinally weighted 18.8% reported that their USC changed during the period. Among adults in the changed USC group, those with private (odds ratio [OR] = 2.0, P = .001) or public (OR = 2.2, P = .001) health insurance and 1 (OR = 1.7, P = .04) or ≥2 (OR = 3.1, P = .02) chronic health conditions were more likely to transition to having a USC from not having a USC, compared with those who had no insurance and no chronic conditions. Compared with those in the changed USC group, those in the never USC group were more likely to report preferring not to have a USC (57.9% vs 80.1%, P < .001). Insurance and public health policies and programs are needed to reduce short-term changes in USC and increase the number of adults with ongoing, consistent USC.

  11. 10 CFR Appendix A to Part 1040 - Federal Financial Assistance of the Department of Energy to Which This Part Applies

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Act, 42 U.S.C. 7101; Public Law 95-91. 12. Nuclear industry seminars. Atomic Energy Act of 1954, as... Non-Nuclear Energy Research and Development Act of 1974; Public Law 93-577; 68 Stat. 1894; 42 U.S.C... energy sciences, high energy and nuclear physics, and advanced technology and assessment projects. Atomic...

  12. 10 CFR Appendix A to Part 1040 - Federal Financial Assistance of the Department of Energy to Which This Part Applies

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Act, 42 U.S.C. 7101; Public Law 95-91. 12. Nuclear industry seminars. Atomic Energy Act of 1954, as... Non-Nuclear Energy Research and Development Act of 1974; Public Law 93-577; 68 Stat. 1894; 42 U.S.C... energy sciences, high energy and nuclear physics, and advanced technology and assessment projects. Atomic...

  13. 10 CFR Appendix A to Part 1040 - Federal Financial Assistance of the Department of Energy to Which This Part Applies

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Act, 42 U.S.C. 7101; Public Law 95-91. 12. Nuclear industry seminars. Atomic Energy Act of 1954, as... Non-Nuclear Energy Research and Development Act of 1974; Public Law 93-577; 68 Stat. 1894; 42 U.S.C... energy sciences, high energy and nuclear physics, and advanced technology and assessment projects. Atomic...

  14. 10 CFR Appendix A to Part 1040 - Federal Financial Assistance of the Department of Energy to Which This Part Applies

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Act, 42 U.S.C. 7101; Public Law 95-91. 12. Nuclear industry seminars. Atomic Energy Act of 1954, as... Non-Nuclear Energy Research and Development Act of 1974; Public Law 93-577; 68 Stat. 1894; 42 U.S.C... energy sciences, high energy and nuclear physics, and advanced technology and assessment projects. Atomic...

  15. 75 FR 35003 - Commission Information Collection Activities (FERC Form No. 580); Request; Submitted for OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...'', OMB Control No. 1902-0137. The Public Utility Regulatory Policies Act (PURPA), enacted November 8... adjustment clauses ``to insure efficient use of resources under such clauses.'' \\1\\ In response to the PURPA... review requirement is set forth in two paragraphs of Section 208 of PURPA, 49 Stat. 851; 16 U.S.C. 824d...

  16. Impact of a Usual Source of Care on Health Care Use, Spending, and Quality Among Adults With Mental Health Conditions.

    PubMed

    Fullerton, Catherine A; Witt, Whitney P; Chow, Clifton M; Gokhale, Manjusha; Walsh, Christine E; Crable, Erika L; Naeger, Sarah

    2018-05-01

    Physical comorbidities associated with mental health conditions contribute to high health care costs. This study examined the impact of having a usual source of care (USC) for physical health on health care utilization, spending, and quality for adults with a mental health condition using Medicaid administrative data. Having a USC decreased the probability of inpatient admissions and readmissions. It decreased expenditures on emergency department visits for physical health, 30-day readmissions, and behavioral health inpatient admissions. It also had a positive effect on several quality measures. Results underscore the importance of a USC for physical health and integrated care for adults with mental health conditions.

  17. p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy.

    PubMed

    Attias-Geva, Zohar; Bentov, Itay; Kidron, Dvora; Amichay, Keren; Sarfstein, Rive; Fishman, Ami; Bruchim, Ilan; Werner, Haim

    2012-07-01

    The role of the insulin-like growth factors (IGF) in endometrial cancer has been well established. The IGF-I receptor (IGF-IR), which mediates the biological actions of IGF-I, is usually overexpressed in endometrial tumours. Uterine serous carcinoma (USC) constitutes a defined histological category among endometrial cancers. Mutation of the p53 gene appears early in the course of the disease and is considered a key event in the initiation of USC. The aim of the present study was to evaluate the potential interactions between p53 and the IGF-IR in USC. In addition, we investigated the role of p53 as a biomarker in IGF-IR targeted therapies. Immunohistochemical analysis in a collection of 35 USC specimens revealed that IGF-IR is highly expressed in primary and metastatic USC. Likewise, p53 was expressed in 85.7% of primary tumours and 100% of metastases. A significant negative correlation between p53 expression and survival was noticed. In addition, using USC-derived cell lines we provide evidence that p53 regulates IGF-IR gene expression via a mechanism that involves repression of the IGF-IR promoter. We show that the mechanism of action of p53 involves interaction with zinc finger protein Sp1, a potent transactivator of the IGF-IR gene. Finally, we demonstrate that USC tumours overexpressing p53 are more likely to benefit from anti-IGF-IR therapies. In summary, we provide evidence that p53 regulates IGF-IR gene expression in USC cells via a mechanism that involves repression of the IGF-IR promoter. The interplay between the p53 and IGF-I signalling pathways is of major basic and translational relevance. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. HER2/neu gene amplification determines the sensitivity of uterine serous carcinoma cell lines to AZD8055, a novel dual mTORC1/2 inhibitor.

    PubMed

    English, Diana P; Roque, Dana M; Carrara, Luisa; Lopez, Salvatore; Bellone, Stefania; Cocco, Emiliano; Bortolomai, Ileana; Schwartz, Peter E; Rutherford, Thomas; Santin, Alessandro D

    2013-12-01

    To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. Twenty-two primary USC cell lines were evaluated for c-erbB2 oncogene amplification by FISH assays. In vitro sensitivity to AZD8055 was evaluated by flow-cytometry-based viability and proliferation assays. Cell cycle profile and downstream cellular responses to AZD8055 were assessed by measuring the DNA content of cells and by phosphorylation of the S6 protein by flow-cytometry. Nine of 22 (40.9%) USC cell lines demonstrated c-erbB2 gene amplification by FISH. AZD8055 caused a strong differential growth inhibition in USC cell lines, with high HER-2/neu-expressors demonstrating significantly higher sensitivity when compared to low HER-2/neu-expressors (AZD-8055 IC50 mean±SEM=0.27±0.05μM in c-erbB2 amplified versus 1.67±0.68μM in c-erbB2 not amplified tumors, P=0.03). AZD8055 growth-inhibition was associated with a significant and dose-dependent increase in the percentage of cells blocked in the G0/G1 cell cycle phase and a dose-dependent decline in pS6 levels in both c-erbB2 amplified vs c-erbB2 not amplified USC cell lines. AZD8055 may represent a novel targeted therapeutic agent in patients harboring advanced/recurrent/refractory USC. c-erbB2 gene amplification may represent a biomarker to identify USC patients who may benefit most from the use of AZD8055. © 2013.

  19. 7 CFR 1.183 - Proceedings covered.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Act of 1937 (7 U.S.C. 608c(15)(A)) Animal Health Protection Act, sections 10414 and 10415 (7 U.S.C... Information Act (7 U.S.C. 2912) Capper-Volstead Act (7 U.S.C. 292) Cotton Research and Promotion Act (7 U.S.C... Research and Promotion Act (7 U.S.C. 2620) Poultry Products Inspection Act (21 U.S.C. 455, 456, 457(d), 467...

  20. BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines.

    PubMed

    Amichay, Keren; Kidron, Debora; Attias-Geva, Zohar; Schayek, Hagit; Sarfstein, Rive; Fishman, Ami; Werner, Haim; Bruchim, Ilan

    2012-06-01

    The insulin-like growth factor I receptor (IGF-IR) and BRCA1 affect cell growth and apoptosis. Little information is available about BRCA1 activity on the IGF signaling pathway. This study evaluated the effect of BRCA1 on IGF-IR expression. BRCA1 and IGF-IR immunohistochemistry on archival tissues (35 uterine serous carcinomas [USCs] and 17 metastases) were performed. USPC1 and USPC2 cell lines were transiently cotransfected with an IGF-IR promoter construct driving a luciferase reporter gene and a BRCA1 expression plasmid. Endogenous IGF-IR levels were evaluated by Western immunoblotting. We found high BRCA1 and IGF-IR protein expression in primary and metastatic USC tumors. All samples were immunostained for BRCA1-71% strongly stained; and 33/35 (94%) were stained positive for IGF-IR-2 (6%) strongly stained. No difference in BRCA1 and IGF-IR staining intensity was noted between BRCA1/2 mutation carriers and noncarriers. Metastatic tumors stained more intensely for BRCA1 than did the primary tumor site (P = 0.041) and with borderline significance for IGF-IR (P = 0.069). BRCA1 and IGF-IR staining did not correlate to survival. BRCA1 expression led to 35% and 54% reduction in IGF-IR promoter activity in the USPC1 and USCP2 cell lines, respectively. Western immunoblotting showed a decline in phosphorylated IGF-IR and phosphorylated AKT in both transiently and stably transfected cells. BRCA1 and IGF-IR are highly expressed in USC tumors. BRCA1 suppresses IGF-IR gene expression and activity. These findings suggest a possible biological link between the BRCA1 and the IGF-I signaling pathways in USC. The clinical implications of this association need to be explored.

  1. 42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

  2. 42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

  3. 42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

  4. 42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

  5. 42 CFR 137.290 - What additional provisions of law are related to NEPA and NHPA?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Archeological Resources Protection Act [16 U.S.C. 470aa]; (3) Clean Air Act [42 U.S.C. 7401]; (4) Clean Water Act [33 U.S.C. 1251]; (5) Coastal Barrier Improvement Act [42 U.S.C. 4028 and 16 U.S.C. Sec. 3501]; (6) Coastal Barrier Resources Act [16 U.S.C. 3501]; (7) Coastal Zone Management Act [16 U.S.C. 1451]; (8...

  6. Department of Defense / General Services Administration / National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... ADMINISTRATION (FAR) Final Rule Stage 492. FAR CASE 2006-005, HUBZONE PROGRAM REVISIONS Legal Authority: 40 USC 121(c); 10 USC ch 137; 42 USC 2473(c) Abstract: The Civilian Agency Acquisition Council and the... REPORTING PROCEDURES Legal Authority: 40 USC 121(c); 10 USC ch 137; 42 USC 2473(c) Abstract: The Civilian...

  7. 78 FR 16443 - Energy Efficiency Program for Consumer Products: Energy Conservation Standards for Ceiling Fans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... with medium screw base sockets, as well as pin-based sockets. (42 U.S.C. 6295(ff)(2)-(3)) The statute... (including candelabra screw base sockets) by January 1, 2007, and if DOE failed to issue such standards by... standards for light kits with sockets other than medium-screw base or pin-based fluorescent lamps in the CFR...

  8. The State-of-the-Art of Materials Technology Used for Fossil and Nuclear Power Plants in China

    NASA Astrophysics Data System (ADS)

    Weng, Yuqing

    Combined with the development of energy in China during the past 30 years, this paper clarified that high steam parameters ultra-supercritical (USC) coal-fired power plants and 1000MW nuclear power plants are the most important method to optimize energy structure and achieve national goals of energy saving and CO2 emission in China. Additionally, requirement of materials technology in high steam parameters USC coal-fired power plants and 1000MW nuclear power plants, current research and major development of relevant materials technology in China were briefly described in this paper.

  9. Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology.

    PubMed

    Guan, Jun-Jie; Niu, Xin; Gong, Fei-Xiang; Hu, Bin; Guo, Shang-Chun; Lou, Yuan-Lei; Zhang, Chang-Qing; Deng, Zhi-Feng; Wang, Yang

    2014-07-01

    Stem cells in human urine have gained attention in recent years; however, urine-derived stem cells (USCs) are far from being well elucidated. In this study, we compared the biological characteristics of USCs with adipose-derived stem cells (ASCs) and investigated whether USCs could serve as a potential cell source for neural tissue engineering. USCs were isolated from voided urine with a modified culture medium. Through a series of experiments, we examined the growth rate, surface antigens, and differentiation potential of USCs, and compared them with ASCs. USCs showed robust proliferation ability. After serial propagation, USCs retained normal karyotypes. Cell surface antigen expression of USCs was similar to ASCs. With lineage-specific induction factors, USCs could differentiate toward the osteogenic, chondrogenic, adipogenic, and neurogenic lineages. To assess the ability of USCs to survive, differentiate, and migrate, they were seeded onto hydrogel scaffold and transplanted into rat brain. The results showed that USCs were able to survive in the lesion site, migrate to other areas, and express proteins that were associated with neural phenotypes. The results of our study demonstrate that USCs possess similar biological characteristics with ASCs and have multilineage differentiation potential. Moreover USCs can differentiate to neuron-like cells in rat brain. The present study shows that USCs are a promising cell source for tissue engineering and regenerative medicine.

  10. Incorporation of antibiotics effective against multidrug resistant pathogens into PMMA for cranio maxillofacial implants

    DTIC Science & Technology

    2018-04-12

    duties. Title 17 USC §105 provides that ‘copyright protection under this title is not available for any work of the US Government.’ Title 17 USC §101...chromatography HPLC High performance liquid chromatography ISO International standardization organization M Minocycline MDR Multidrug resistant...used for the past few decades as topical otic and ophthalmic treatments. Literature available for the individual colistin-, polymyxin B-, and

  11. Creep-Rupture Behavior and Recrystallization in HR6W and Haynes Alloy 230 Cold-Bent Boiler Tubing for Ultrasupercritical (USC) Steam Boiler Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shingledecker, John P

    2007-01-01

    Creep-rupture experiments were conducted on HR6W and Haynes 230, candidate Ultrasupercritical (USC) alloys, tubes to evaluate the effects of cold-work and recrystallization during high-temperature service. These creep tests were performed by internally pressurizing cold-bent boiler tubes at 775 C for times up to 8000 hours. The bends were fabricated with cold-work levels beyond the current ASME Boiler and Pressure Vessel (ASME B&PV) Code Section I limits for austenitic stainless steels. Destructive metallographic evaluation of the crept tube bends was used to determine the effects of cold-work and the degree of recrystallization. The metallographic analysis combined with an evaluation of themore » creep and rupture data suggest that solid-solution strengthened nickel-based alloys can be fabricated for high-temperature service at USC conditions utilizing levels of cold-work higher than the current allowed levels for austenitic stainless steels.« less

  12. 50 CFR 10.1 - Purpose of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

  13. 50 CFR 10.1 - Purpose of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

  14. 50 CFR 10.1 - Purpose of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

  15. 50 CFR 10.1 - Purpose of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

  16. 50 CFR 10.1 - Purpose of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... wildlife: Lacey Act, 18 U.S.C. 42. Lacey Act Amendments of 1981, 16 U.S.C. 3371-3378. Migratory Bird Treaty Act, 16 U.S.C. 703-712. Bald and Golden Eagle Protection Act, 16 U.S.C. 668a-668d. Endangered Species Act of 1973, 16 U.S.C. 1531-1543. Tariff Classification Act of 1962, 19 U.S.C. 1202, [Schedule 1, Part...

  17. 12 CFR 263.65 - Civil penalty inflation adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) First tier—$7,500. (ii) Second tier—$37,500. (iii) Third tier—$1,425,000. (3) 12 U.S.C. 1820(k)(6)(A)(ii...) 12 U.S.C. 1467a(i)(2)—$32,500. (ii) 12 U.S.C. 1467a(i)(3)—$32,500. (12) 12 U.S.C. 1467a(r): (i) 12 U.S.C. 1467a(r)(1)—$3,200. (ii) 12 U.S.C. 1467a(r)(2)—$32,500. (iii) 12 U.S.C. 1467a(r)(3)—$1,425,000...

  18. 12 CFR 263.65 - Civil penalty inflation adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) First tier—$7,500. (ii) Second tier—$37,500. (iii) Third tier—$1,425,000. (3) 12 U.S.C. 1820(k)(6)(A)(ii...) 12 U.S.C. 1467a(i)(2)—$32,500. (ii) 12 U.S.C. 1467a(i)(3)—$32,500. (12) 12 U.S.C. 1467a(r): (i) 12 U.S.C. 1467a(r)(1)—$3,200. (ii) 12 U.S.C. 1467a(r)(2)—$32,500. (iii) 12 U.S.C. 1467a(r)(3)—$1,425,000...

  19. Parent and Child Usual Source of Care and Children’s Receipt of Health Care Services

    PubMed Central

    DeVoe, Jennifer E.; Tillotson, Carrie J.; Wallace, Lorraine S.; Angier, Heather; Carlson, Matthew J.; Gold, Rachel

    2011-01-01

    PURPOSE In the United States, children who have a usual source of care (USC) have better access to health care than those who do not, but little is known about how parental USC affects children’s access. We examined the association between child and parent USC patterns and children’s access to health care services. METHODS We undertook a secondary analysis of nationally representative, cross-sectional data from children participating in the 2002–2007 Medical Expenditure Panel Survey (n = 56,302). We assessed 10 outcome measures: insurance coverage gaps, no doctor visits in the past year, less than yearly dental visits, unmet medical and prescription needs, delayed care, problems getting care, and unmet preventive counseling needs regarding healthy eating, regular exercise, car safety devices, and bicycle helmets. RESULTS Among children, 78.6% had a USC and at least 1 parent with a USC, whereas 12.4% had a USC but no parent USC. Children with a USC but no parent USC had a higher likelihood of several unmet needs, including an insurance coverage gap (adjusted risk ratio [aRR] 1.33; 95% confidence interval [CI], 1.21–1.47), an unmet medical or prescription need (aRR 1.70; 95% CI 1.09–2.65), and no yearly dental visits (aRR 1.12; 95% CI 1.06–1.18), compared with children with a USC whose parent(s) had a USC. CONCLUSIONS Among children with a USC, having no parent USC was associated with a higher likelihood of reporting unmet needs when compared with children whose parent(s) had a USC. Policy reforms should ensure access to a USC for all family members. PMID:22084261

  20. Parent and child usual source of care and children's receipt of health care services.

    PubMed

    DeVoe, Jennifer E; Tillotson, Carrie J; Wallace, Lorraine S; Angier, Heather; Carlson, Matthew J; Gold, Rachel

    2011-01-01

    PURPOSE In the United States, children who have a usual source of care (USC) have better access to health care than those who do not, but little is known about how parental USC affects children's access. We examined the association between child and parent USC patterns and children's access to health care services. METHODS We undertook a secondary analysis of nationally representative, cross-sectional data from children participating in the 2002-2007 Medical Expenditure Panel Survey (n = 56,302). We assessed 10 outcome measures: insurance coverage gaps, no doctor visits in the past year, less than yearly dental visits, unmet medical and prescription needs, delayed care, problems getting care, and unmet preventive counseling needs regarding healthy eating, regular exercise, car safety devices, and bicycle helmets. RESULTS Among children, 78.6% had a USC and at least 1 parent with a USC, whereas 12.4% had a USC but no parent USC. Children with a USC but no parent USC had a higher likelihood of several unmet needs, including an insurance coverage gap (adjusted risk ratio [aRR] 1.33; 95% confidence interval [CI], 1.21-1.47), an unmet medical or prescription need (aRR 1.70; 95% CI 1.09-2.65), and no yearly dental visits (aRR 1.12; 95% CI 1.06-1.18), compared with children with a USC whose parent(s) had a USC. CONCLUSIONS Among children with a USC, having no parent USC was associated with a higher likelihood of reporting unmet needs when compared with children whose parent(s) had a USC. Policy reforms should ensure access to a USC for all family members.

  1. Effect of Having a Usual Source of Care on Health Care Outcomes Among Children With Serious Emotional Disturbance.

    PubMed

    Witt, Whitney P; Fullerton, Catherine A; Chow, Clifton; Gokhale, Manjusha; Naeger, Sarah; Walsh, Christine; Karnell, Lucy

    To determine the influence of a usual source of care (USC) on health care utilization, expenditures, and quality for Medicaid-insured children and adolescents with a serious emotional disturbance (SED). Administrative claims data for 2011-2012 were extracted from the Truven Health MarketScan Multi-State Medicaid Research Database for 286,585 children and adolescents with a primary diagnosis of SED. We used propensity score-adjusted multivariate regressions to determine whether having a USC had a significant effect on utilization and expenditures for high-cost services that are considered potentially avoidable with appropriate outpatient care: physical and behavioral health inpatient admissions, emergency department (ED) visits, and hospital readmissions. Propensity score-adjusted regressions indicated that children with a USC had fewer inpatient admissions related to behavioral health (adjusted odds ratio [AOR] = 0.87; 95% confidence interval [CI], 0.79-0.97) and physical health (AOR = 0.91; 95% CI, 0.89-0.93) and lower expenditures for behavioral health inpatient admissions, physical health ED visits, and readmissions. Having a USC also was associated with a higher likelihood of receiving quality health care for 4 physical health and 2 behavioral health measures. Having a USC improved the health care of Medicaid-insured children and adolescents with an SED. However, despite having insurance, approximately one-fourth of this patient population did not appear to have a USC. This information can be used in developing programs that encourage connections with comprehensive health care that provides coordination among various providers. Copyright © 2016 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  2. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases.

    PubMed

    Niitsu, Hiroaki; Hinoi, Takao; Shimomura, Manabu; Egi, Hiroyuki; Hattori, Minoru; Ishizaki, Yasuyo; Adachi, Tomohiro; Saito, Yasufumi; Miguchi, Masashi; Sawada, Hiroyuki; Kochi, Masatoshi; Mukai, Shoichiro; Ohdan, Hideki

    2015-04-24

    In stage IV colorectal cancer (CRC) with unresectable metastases, whether or not resection of the primary tumor should be indicated remains controversial. We aim to determine the impact of primary tumor resection on the survival of stage IV CRC patients with unresectable metastases. We retrospectively investigated 103 CRC patients with stage IV colorectal cancer with metastases, treated at Hiroshima University Hospital between 2007 and 2013. Of these, those who had resectable primary tumor but unresectable metastases and received any chemotherapy were included in the study. We analyzed the overall survival (OS) and short-term outcomes between the patients who received up-front systemic chemotherapy (USC group) and those who received primary tumor resection followed by chemotherapy (PTR group). Of the 57 included patients, 15 underwent USC and 42 PTR. The median survival times were 13.4 and 23.9 months in the USC and PTR groups, respectively (P = 0.093), but multivariate analysis for the overall survival showed no significant difference between the two groups (hazard ratio, 1.30; 95% confidence interval (CI), 0.60 to 2.73, P = 0.495). In the USC group, the disease control rate of primary tumor was observed in 12 patients (80.0%), but emergency laparotomy was required for 1 patient. Morbidity in the PTR group was observed in 18 cases (42.9%). The overall survival did not differ significantly between the USC and PTR groups. USC may help avoid unnecessary resection and consequently the high morbidity rate associated with primary tumor resection for stage IV CRC with unresectable metastases.

  3. Environmental Assessment: Demolish CASS Switch Stations Buildings 644, 645, 646 at Grand Forks Air Force Base

    DTIC Science & Technology

    2006-06-01

    Per Year TSCA Toxic Substance Control Act TSI Thermal System Insulation UAV Unmanned Aerial Vehicle UHF Ultra High Frequency UPS Uninterruptible...Conservation and Recovery Act (RCRA) of 1976 [42 U.S.C. Sec. 6901, et seq.] • Toxic Substances Control Act (TSCA) of 1976 [15 U.S.C. Sec. 2601, et...Corporation (SAIC). Typical hazardous materials include reactive materials such as explosives, ignitables, toxics , and corrosives. Improper storage can

  4. A medical home versus temporary housing: the importance of a stable usual source of care.

    PubMed

    DeVoe, Jennifer E; Saultz, John W; Krois, Lisa; Tillotson, Carrie J

    2009-11-01

    Little is known about how the stability of a usual source of care (USC) affects access to care. We examined the prevalence of USC changes among low-income children and how these changes were associated with unmet health care need. We conducted a cross-sectional survey of Oregon's food stamp program in 2005. We analyzed primary data from 2681 surveys and then weighted results to 84087 families, adjusting for oversampling and nonresponse. We then ascertained the percentage of children in the Oregon population who had ever changed a USC for insurance reasons, which characteristics were associated with USC change, and how USC change was associated with unmet need. We also conducted a posthoc analysis of data from the Medical Expenditure Panel Survey to confirm similarities between the Oregon sample and a comparable national sample. Children without a USC in the Oregon population had greater odds of reporting an unmet health care need than those with a USC. This pattern was similar in national estimates. Among the Oregon sample, 23% had changed their USC because of insurance reasons, and 10% had no current USC. Compared with children with a stable USC, children who had changed their USC had greater odds of reporting unmet medical need, unmet prescription need, delayed care, unmet dental need, and unmet counseling need. This study highlights the importance of ensuring stability with a USC. Moving low-income children into new medical homes could disturb existing USC relationships, thereby merely creating "temporary housing."

  5. Papillary syncytial metaplasia associated with endometrial breakdown exhibits an immunophenotype that overlaps with uterine serous carcinoma.

    PubMed

    McCluggage, W Glenn; McBride, Hilary A

    2012-05-01

    Uterine serous carcinoma (USC) is an aggressive variant of Type 2 endometrial carcinoma, which in most cases exhibits, at least focally, a papillary architecture. Occasionally, especially in small biopsy specimens, it may be difficult to distinguish between USC and a variety of metaplastic or reactive processes. In particular, papillary syncytial metaplasia (PSM), as a result of endometrial breakdown, may be confused with USC or its precursor serous endometrial intraepithelial carcinoma. In such cases, immunohistochemistry is often undertaken, the panel of markers usually including estrogen receptor (ER), p53, p16, and MIB1. The expected immunoprofile of USC is ER negative, p53 and p16 positive, and a high MIB1 proliferation index, although studies have shown that significant numbers of cases deviate from this immunophenotype. With regard to the aforementioned markers, PSM has not been studied extensively, but intuitively, the expected immunophenotype would be ER positive, p53 and p16 negative, and a low MIB1 proliferation index. After 2 index cases in which breaking down menstrual endometrium with florid PSM was misdiagnosed on an endometrial biopsy as USC or suspected USC, in part due to the observed immunophenotype, we studied the expression of ER, p53, p16, MIB1, and HMGA2 (a recently described useful marker of USC) in 10 further cases of PSM associated with endometrial breakdown. We illustrate that compared with a nonbreaking down endometrium, PSM is characterized by a decreased expression of ER and an increased expression of p53 (although still wild-type staining) and p16, the latter marker typically being diffusely positive. HMGA2 is negative, and there is a low MIB1 proliferation index. In cases of PSM, which are morphologically problematic, the immunophenotype may further heighten the suspicion of serous malignancy and potentially result in a misdiagnosis.

  6. 48 CFR 215.403-1 - Prohibition on obtaining cost or pricing data (10 U.S.C. 2306a and 41 U.S.C. 254b).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cost or pricing data (10 U.S.C. 2306a and 41 U.S.C. 254b). 215.403-1 Section 215.403-1 Federal... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.403-1 Prohibition on obtaining cost or pricing data (10 U.S.C. 2306a and 41 U.S.C. 254b). (b) Exceptions to cost or pricing data...

  7. 12 CFR 263.65 - Civil penalty inflation adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... tier—$7,500. (ii) Second tier—$37,500. (iii) Third tier—$1,375,000. (3) 12 U.S.C. 1820(k)(6)(A)(ii...) 12 U.S.C. 1467a(i)(3)-$32,500. (12) 12 U.S.C. 1467a(r): (i) 12 U.S.C. 1467a(r)(1)-$ 2,200. (ii) 12 U.S.C. 1467a(r)(2)-$32,500. (iii) 12 U.S.C. 1467a(r)(3)-$1,375,000. [73 FR 58032, Oct. 6, 2008, as...

  8. 49 CFR 1105.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... decisionmaking process pursuant to the National Environmental Policy Act, 42 U.S.C. 4332; the Energy Policy and Conservation Act, 42 U.S.C. 6362(b); and related laws, including the National Historic Preservation Act, 16 U.S.C. 470f, the Coastal Zone Management Act, 16 U.S.C. 1451, and the Endangered Species Act, 16 U.S.C...

  9. 49 CFR 1105.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... decisionmaking process pursuant to the National Environmental Policy Act, 42 U.S.C. 4332; the Energy Policy and Conservation Act, 42 U.S.C. 6362(b); and related laws, including the National Historic Preservation Act, 16 U.S.C. 470f, the Coastal Zone Management Act, 16 U.S.C. 1451, and the Endangered Species Act, 16 U.S.C...

  10. 49 CFR 1105.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... decisionmaking process pursuant to the National Environmental Policy Act, 42 U.S.C. 4332; the Energy Policy and Conservation Act, 42 U.S.C. 6362(b); and related laws, including the National Historic Preservation Act, 16 U.S.C. 470f, the Coastal Zone Management Act, 16 U.S.C. 1451, and the Endangered Species Act, 16 U.S.C...

  11. 49 CFR 1105.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... decisionmaking process pursuant to the National Environmental Policy Act, 42 U.S.C. 4332; the Energy Policy and Conservation Act, 42 U.S.C. 6362(b); and related laws, including the National Historic Preservation Act, 16 U.S.C. 470f, the Coastal Zone Management Act, 16 U.S.C. 1451, and the Endangered Species Act, 16 U.S.C...

  12. 49 CFR 1105.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... decisionmaking process pursuant to the National Environmental Policy Act, 42 U.S.C. 4332; the Energy Policy and Conservation Act, 42 U.S.C. 6362(b); and related laws, including the National Historic Preservation Act, 16 U.S.C. 470f, the Coastal Zone Management Act, 16 U.S.C. 1451, and the Endangered Species Act, 16 U.S.C...

  13. Container Management: A Necessary Strategy for Improved Efficiencies

    DTIC Science & Technology

    2013-03-01

    and carrier-owned containers under the USTRANSCOM USC or other applicable contract.21 Re-organize mobile container assessment teams ( MCAT ) with...warrant officer or field grade officers in charge. The MCATs are a great concept, but when a team shows up with a young Captain or Lieutenant and a...and a master sergeant or sergeant major on the MCAT , they will be more effective and better supported. Plenty of quality field grade Logistics Corps

  14. 33 CFR 27.3 - Penalty Adjustment Table.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Manufacture 8,000 33 U.S.C. 1608(a) International Navigation Rules; Operator 8,000 33 U.S.C. 1608(b) International Navigation Rules; Vessel 8,000 33 U.S.C. 1908(b)(1) Pollution from Ships; General 40,000 33 U.S.C... (Judicial Assessment subsequent offense) 100,000 46 U.S.C. App 1505(a)(2) Safe Containers for International...

  15. 7 CFR Appendix to Subpart F of... - Unknown Title

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... U.S.C. 1773. 15. Special Food Service Program for Children. 42 U.S.C. 1761. 16. Special Supplemental Food Program for Women, Infants, and Children. 42 U.S.C. 1786. 17. Cash grants to States for nutrition... development programs. 40 U.S.C. 204. 8. Advance of funds for cooperative research. 16 U.S.C. 581i-l. 9...

  16. 7 CFR Appendix to Subpart F of... - Unknown Title

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... U.S.C. 1773. 15. Special Food Service Program for Children. 42 U.S.C. 1761. 16. Special Supplemental Food Program for Women, Infants, and Children. 42 U.S.C. 1786. 17. Cash grants to States for nutrition... development programs. 40 U.S.C. 204. 8. Advance of funds for cooperative research. 16 U.S.C. 581i-l. 9...

  17. 7 CFR Appendix to Subpart F of... - Unknown Title

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... U.S.C. 1773. 15. Special Food Service Program for Children. 42 U.S.C. 1761. 16. Special Supplemental Food Program for Women, Infants, and Children. 42 U.S.C. 1786. 17. Cash grants to States for nutrition... development programs. 40 U.S.C. 204. 8. Advance of funds for cooperative research. 16 U.S.C. 581i-l. 9...

  18. 7 CFR Appendix to Subpart F of... - Unknown Title

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... U.S.C. 1773. 15. Special Food Service Program for Children. 42 U.S.C. 1761. 16. Special Supplemental Food Program for Women, Infants, and Children. 42 U.S.C. 1786. 17. Cash grants to States for nutrition... development programs. 40 U.S.C. 204. 8. Advance of funds for cooperative research. 16 U.S.C. 581i-l. 9...

  19. 7 CFR Appendix to Subpart F of... - Unknown Title

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... U.S.C. 1773. 15. Special Food Service Program for Children. 42 U.S.C. 1761. 16. Special Supplemental Food Program for Women, Infants, and Children. 42 U.S.C. 1786. 17. Cash grants to States for nutrition... development programs. 40 U.S.C. 204. 8. Advance of funds for cooperative research. 16 U.S.C. 581i-l. 9...

  20. 77 FR 48203 - Final Federal Agency Actions on Proposed Highway in North Carolina

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... Wetlands Mitigation [23 U.S.C. 103(b)(6)(m), 133(b)(11)]; Flood Disaster Protection Act [42 U.S.C. 4001... Species Act [16 USC 1531-1544 and Section 1536], Marine Mammal Protection Act [16 U.S.C. 1361], Anadromous....]; Archeological Resources Protection Act of 1977 [16 U.S.C. 470(aa)-11]; Archeological and Historic Preservation...

  1. 77 FR 7946 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... for Infusion Pumps. 344 Requirements for the 0910-AG59 Testing and Reporting of Tobacco Product... Infusion Pumps Legal Authority: 21 U.S.C. 351; 21 U.S.C. 360; 21 U.S.C. 360c; 21 U.S.C. 360e; 21 U.S.C... infusion pumps. An analysis of the reports reveals that a majority of the recalls and failures were caused...

  2. USC orthogonal multiprocessor for image processing with neural networks

    NASA Astrophysics Data System (ADS)

    Hwang, Kai; Panda, Dhabaleswar K.; Haddadi, Navid

    1990-07-01

    This paper presents the architectural features and imaging applications of the Orthogonal MultiProcessor (OMP) system, which is under construction at the University of Southern California with research funding from NSF and assistance from several industrial partners. The prototype OMP is being built with 16 Intel i860 RISC microprocessors and 256 parallel memory modules using custom-designed spanning buses, which are 2-D interleaved and orthogonally accessed without conflicts. The 16-processor OMP prototype is targeted to achieve 430 MIPS and 600 Mflops, which have been verified by simulation experiments based on the design parameters used. The prototype OMP machine will be initially applied for image processing, computer vision, and neural network simulation applications. We summarize important vision and imaging algorithms that can be restructured with neural network models. These algorithms can efficiently run on the OMP hardware with linear speedup. The ultimate goal is to develop a high-performance Visual Computer (Viscom) for integrated low- and high-level image processing and vision tasks.

  3. 50 CFR 12.6 - Bonded release.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., payment of the value as determined under § 12.12) in place of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Marine Mammal Protection Act, 16 U.S.C. 1361 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Airborne Hunting Act, 16 U.S.C. 742j...

  4. 50 CFR 12.12 - Appraisement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Protection Act, 16 U.S.C. 1361 et seq., and the value of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1, et seq.; or the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq. If the seized property may...

  5. 50 CFR 12.12 - Appraisement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Protection Act, 16 U.S.C. 1361 et seq., and the value of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1, et seq.; or the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq. If the seized property may...

  6. 50 CFR 12.2 - Scope of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Act, 16 U.S.C. 1361 et seq.; (h) The Endangered Species Act, 16 U.S.C. 1531 et seq.; and (i) The Lacey... the following laws: (a) The Eagle Protection Act, 16 U.S.C. 668 et seq.; (b) The National Wildlife Refuge System Administration Act, 16 U.S.C. 668dd et seq.; (c) The Migratory Bird Treaty Act, 16 U.S.C...

  7. 50 CFR 12.2 - Scope of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Act, 16 U.S.C. 1361 et seq.; (h) The Endangered Species Act, 16 U.S.C. 1531 et seq.; and (i) The Lacey... the following laws: (a) The Eagle Protection Act, 16 U.S.C. 668 et seq.; (b) The National Wildlife Refuge System Administration Act, 16 U.S.C. 668dd et seq.; (c) The Migratory Bird Treaty Act, 16 U.S.C...

  8. 50 CFR 12.12 - Appraisement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Protection Act, 16 U.S.C. 1361 et seq., and the value of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1, et seq.; or the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq. If the seized property may...

  9. 43 CFR 8340.0-3 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of this part are issued under the Federal Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.); the Taylor Grazing Act (43 U.S.C. 315a); the Endangered Species Act (16 U.S.C. 1531 et seq.); the Wild and Scenic Rivers Act (16 U.S.C. 1281c); the Act of September 15, 1960, as amended (16 U.S.C...

  10. 50 CFR 12.6 - Bonded release.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., payment of the value as determined under § 12.12) in place of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Marine Mammal Protection Act, 16 U.S.C. 1361 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Airborne Hunting Act, 16 U.S.C. 742j...

  11. 43 CFR 8340.0-3 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of this part are issued under the Federal Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.); the Taylor Grazing Act (43 U.S.C. 315a); the Endangered Species Act (16 U.S.C. 1531 et seq.); the Wild and Scenic Rivers Act (16 U.S.C. 1281c); the Act of September 15, 1960, as amended (16 U.S.C...

  12. 50 CFR 12.6 - Bonded release.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., payment of the value as determined under § 12.12) in place of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Marine Mammal Protection Act, 16 U.S.C. 1361 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Airborne Hunting Act, 16 U.S.C. 742j...

  13. 50 CFR 12.12 - Appraisement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Protection Act, 16 U.S.C. 1361 et seq., and the value of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1, et seq.; or the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq. If the seized property may...

  14. 50 CFR 12.12 - Appraisement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Protection Act, 16 U.S.C. 1361 et seq., and the value of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1, et seq.; or the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq. If the seized property may...

  15. 43 CFR 8340.0-3 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of this part are issued under the Federal Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.); the Taylor Grazing Act (43 U.S.C. 315a); the Endangered Species Act (16 U.S.C. 1531 et seq.); the Wild and Scenic Rivers Act (16 U.S.C. 1281c); the Act of September 15, 1960, as amended (16 U.S.C...

  16. 50 CFR 12.2 - Scope of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Act, 16 U.S.C. 1361 et seq.; (h) The Endangered Species Act, 16 U.S.C. 1531 et seq.; and (i) The Lacey... the following laws: (a) The Eagle Protection Act, 16 U.S.C. 668 et seq.; (b) The National Wildlife Refuge System Administration Act, 16 U.S.C. 668dd et seq.; (c) The Migratory Bird Treaty Act, 16 U.S.C...

  17. 50 CFR 12.6 - Bonded release.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., payment of the value as determined under § 12.12) in place of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Marine Mammal Protection Act, 16 U.S.C. 1361 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Airborne Hunting Act, 16 U.S.C. 742j...

  18. 43 CFR 8340.0-3 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of this part are issued under the Federal Land Policy and Management Act of 1976 (43 U.S.C. 1701 et seq.); the Taylor Grazing Act (43 U.S.C. 315a); the Endangered Species Act (16 U.S.C. 1531 et seq.); the Wild and Scenic Rivers Act (16 U.S.C. 1281c); the Act of September 15, 1960, as amended (16 U.S.C...

  19. 50 CFR 12.2 - Scope of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Act, 16 U.S.C. 1361 et seq.; (h) The Endangered Species Act, 16 U.S.C. 1531 et seq.; and (i) The Lacey... the following laws: (a) The Eagle Protection Act, 16 U.S.C. 668 et seq.; (b) The National Wildlife Refuge System Administration Act, 16 U.S.C. 668dd et seq.; (c) The Migratory Bird Treaty Act, 16 U.S.C...

  20. 50 CFR 12.6 - Bonded release.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., payment of the value as determined under § 12.12) in place of any property seized under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Marine Mammal Protection Act, 16 U.S.C. 1361 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Airborne Hunting Act, 16 U.S.C. 742j...

  1. 50 CFR 12.2 - Scope of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Act, 16 U.S.C. 1361 et seq.; (h) The Endangered Species Act, 16 U.S.C. 1531 et seq.; and (i) The Lacey... the following laws: (a) The Eagle Protection Act, 16 U.S.C. 668 et seq.; (b) The National Wildlife Refuge System Administration Act, 16 U.S.C. 668dd et seq.; (c) The Migratory Bird Treaty Act, 16 U.S.C...

  2. 23 CFR 420.103 - How does the FHWA define the terms used in this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... provisions of 23 U.S.C. 134); (3) National highway system (NHS) funds authorized under 23 U.S.C. 104(b)(1... and establishment of management systems under 23 U.S.C. 303; (4) Surface transportation program (STP... management systems under 23 U.S.C. 303; and (5) Minimum guarantee (MG) funds authorized under 23 U.S.C. 505...

  3. 23 CFR Appendix A to Part 773 - FHWA Environmental Responsibilities That May Be Assigned Under Section 6005

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 1536 Marine Mammal Protection Act, 16 U.S.C. 1361 Anadromous Fish Conservation Act, 16 U.S.C. 757... 1966, as amended, 16 U.S.C. 470(f) et seq. Archeological Resources Protection Act of 1977, 16 U.S.C... Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3001-3013 Social and Economic Impacts American Indian...

  4. 23 CFR Appendix A to Part 773 - FHWA Environmental Responsibilities That May Be Assigned Under Section 6005

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 1536 Marine Mammal Protection Act, 16 U.S.C. 1361 Anadromous Fish Conservation Act, 16 U.S.C. 757... 1966, as amended, 16 U.S.C. 470(f) et seq. Archeological Resources Protection Act of 1977, 16 U.S.C... Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3001-3013 Social and Economic Impacts American Indian...

  5. 23 CFR Appendix A to Part 773 - FHWA Environmental Responsibilities That May Be Assigned Under Section 6005

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Section 1536 Marine Mammal Protection Act, 16 U.S.C. 1361 Anadromous Fish Conservation Act, 16 U.S.C. 757... 1966, as amended, 16 U.S.C. 470(f) et seq. Archeological Resources Protection Act of 1977, 16 U.S.C... Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3001-3013 Social and Economic Impacts American Indian...

  6. 23 CFR Appendix A to Part 773 - FHWA Environmental Responsibilities That May Be Assigned Under Section 6005

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 1536 Marine Mammal Protection Act, 16 U.S.C. 1361 Anadromous Fish Conservation Act, 16 U.S.C. 757... 1966, as amended, 16 U.S.C. 470(f) et seq. Archeological Resources Protection Act of 1977, 16 U.S.C... Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3001-3013 Social and Economic Impacts American Indian...

  7. 23 CFR Appendix A to Part 773 - FHWA Environmental Responsibilities That May Be Assigned Under Section 6005

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 1536 Marine Mammal Protection Act, 16 U.S.C. 1361 Anadromous Fish Conservation Act, 16 U.S.C. 757... 1966, as amended, 16 U.S.C. 470(f) et seq. Archeological Resources Protection Act of 1977, 16 U.S.C... Protection and Repatriation Act (NAGPRA), 25 U.S.C. 3001-3013 Social and Economic Impacts American Indian...

  8. 45 CFR 97.12 - Which grants may be consolidated?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... in § 97.12(a)(1). (4) Social Services, 42 U.S.C. 1397-1397f. (5) Community Services, 42 U.S.C. 9901-9912. (6) Low-Income Home Energy Assistance, 42 U.S.C. 8621-8629. (7) Community Youth Activity, 42 U.S... Violence Prevention and Services, 42 U.S.C. 10401, et seq. (9) Children's Justice Act, 42 U.S.C. 5101, et...

  9. Boiler materials for ultra supercritical coal power plants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Purgert, Robert; Shingledecker, John; Pschirer, James

    2015-12-29

    The U.S. Department of Energy (DOE) and the Ohio Coal Development Office (OCDO) have undertaken a project aimed at identifying, evaluating, and qualifying the materials needed for the construction of the critical components of coal-fired boilers capable of operating at much higher efficiencies than current generation of supercritical plants. This increased efficiency is expected to be achieved principally through the use of advanced ultrasupercritical (A-USC) steam conditions up to 760°C (1400°F) and 35 MPa (5000 psi). A limiting factor to achieving these higher temperatures and pressures for future A-USC plants are the materials of construction. The goal of this projectmore » is to assess/develop materials technology to build and operate an A-USC boiler capable of delivering steam with conditions up to 760°C (1400°F)/35 MPa (5000 psi). The project has successfully met this goal through a focused long-term public-private consortium partnership. The project was based on an R&D plan developed by the Electric Power Research Institute (EPRI) and an industry consortium that supplemented the recommendations of several DOE workshops on the subject of advanced materials. In view of the variety of skills and expertise required for the successful completion of the proposed work, a consortium led by the Energy Industries of Ohio (EIO) with cost-sharing participation of all the major domestic boiler manufacturers, ALSTOM Power (Alstom), Babcock and Wilcox Power Generation Group, Inc. (B&W), Foster Wheeler (FW), and Riley Power, Inc. (Riley), technical management by EPRI and research conducted by Oak Ridge National Laboratory (ORNL) has been developed. The project has clearly identified and tested materials that can withstand 760°C (1400°F) steam conditions and can also make a 700°C (1300°F) plant more economically attractive. In this project, the maximum temperature capabilities of these and other available high-temperature alloys have been assessed to provide a basis for materials selection and application under a range of conditions prevailing in the boiler. A major effort involving eight tasks was completed in Phase 1. In a subsequent Phase 2 extension, the earlier defined tasks were extended to finish and enhance the Phase 1 activities. This extension included efforts in improved weld/weldment performance, development of longer-term material property databases, additional field (in-plant) corrosion testing, improved understanding of long-term oxidation kinetics and exfoliation, cyclic operation, and fabrication methods for waterwalls. In addition, preliminary work was undertaken to model an oxyfuel boiler to define local environments expected to occur and to study corrosion behavior of alloys under these conditions. This final technical report provides a comprehensive summary of all the work undertaken by the consortium and the research findings from all eight (8) technical tasks including A-USC boiler design and economics (Task 1), long-term materials properties (Task 2), steam- side oxidation (Task 3), Fireside Corrosion (Task 4), Welding (Task 5), Fabricability (Task 6), Coatings (Task 7), and Design Data and Rules (Task 8).« less

  10. High Frequency, High Gradient Dielectric Wakefield Acceleration Experiments at SLAC and BNL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenzweig, James; /UCLA; Travish, Gil

    Given the recent success of >GV/m dielectric wakefield accelerator (DWA) breakdown experiments at SLAC, and follow-on coherent Cerenkov radiation production at the UCLA Neptune, a UCLA-USC-SLAC collaboration is now implementing a new set of experiments that explore various DWA scenarios. These experiments are motivated by the opportunities presented by the approval of FACET facility at SLAC, as well as unique pulse-train wakefield drivers at BNL. The SLAC experiments permit further exploration of the multi-GeV/m envelope in DWAs, and will entail investigations of novel materials (e.g. CVD diamond) and geometries (Bragg cylindrical structures, slab-symmetric DWAs), and have an over-riding goal ofmore » demonstrating >GeV acceleration in {approx}33 cm DWA tubes. In the nearer term before FACET's commissioning, we are planning measurements at the BNL ATF, in which we drive {approx}50-200 MV/m fields with single pulses or pulse trains. These experiments are of high relevance to enhancing linear collider DWA designs, as they will demonstrate potential for efficient operation with pulse trains.« less

  11. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes

    NASA Astrophysics Data System (ADS)

    Jing, Lin; Brun, Todd; Quantum Research Team

    Quasi-cyclic LDPC codes can approach the Shannon capacity and have efficient decoders. Manabu Hagiwara et al., 2007 presented a method to calculate parity check matrices with high girth. Two distinct, orthogonal matrices Hc and Hd are used. Using submatrices obtained from Hc and Hd by deleting rows, we can alter the code rate. The submatrix of Hc is used to correct Pauli X errors, and the submatrix of Hd to correct Pauli Z errors. We simulated this system for depolarizing noise on USC's High Performance Computing Cluster, and obtained the block error rate (BER) as a function of the error weight and code rate. From the rates of uncorrectable errors under different error weights we can extrapolate the BER to any small error probability. Our results show that this code family can perform reasonably well even at high code rates, thus considerably reducing the overhead compared to concatenated and surface codes. This makes these codes promising as storage blocks in fault-tolerant quantum computation. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes.

  12. 50 CFR 12.25 - Transfers in settlement of civil penalty claims.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... may be liable for civil penalty under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; or Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., may be given an opportunity to...

  13. 25 CFR Appendix A to Subpart D - Cultural Resource and Environmental Requirements for the IRR Program

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... limited to: 1. 16 U.S.C. 1531, Endangered Species Act. 2. 16 U.S.C. 4601, Land and Water Conservation Fund Act (Section 6(f)). 3. 16 U.S.C. 661-667d, Fish and Wildlife Coordination Act. 4. 23 U.S.C. 138.... 10. 7 U.S.C. 4201, Farmland Protection Policy Act. 11. 50 CFR part 402, Endangered Species Act...

  14. 50 CFR 12.25 - Transfers in settlement of civil penalty claims.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... may be liable for civil penalty under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; or Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., may be given an opportunity to...

  15. 25 CFR Appendix A to Subpart D - Cultural Resource and Environmental Requirements for the IRR Program

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... limited to: 1. 16 U.S.C. 1531, Endangered Species Act. 2. 16 U.S.C. 4601, Land and Water Conservation Fund Act (Section 6(f)). 3. 16 U.S.C. 661-667d, Fish and Wildlife Coordination Act. 4. 23 U.S.C. 138.... 10. 7 U.S.C. 4201, Farmland Protection Policy Act. 11. 50 CFR part 402, Endangered Species Act...

  16. 50 CFR 12.25 - Transfers in settlement of civil penalty claims.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... may be liable for civil penalty under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; or Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., may be given an opportunity to...

  17. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  18. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  19. 25 CFR Appendix A to Subpart D - Cultural Resource and Environmental Requirements for the IRR Program

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... limited to: 1. 16 U.S.C. 1531, Endangered Species Act. 2. 16 U.S.C. 4601, Land and Water Conservation Fund Act (Section 6(f)). 3. 16 U.S.C. 661-667d, Fish and Wildlife Coordination Act. 4. 23 U.S.C. 138.... 10. 7 U.S.C. 4201, Farmland Protection Policy Act. 11. 50 CFR part 402, Endangered Species Act...

  20. 50 CFR 12.25 - Transfers in settlement of civil penalty claims.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... may be liable for civil penalty under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; or Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., may be given an opportunity to...

  1. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  2. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  3. 50 CFR 12.22 - Civil actions to obtain forfeiture.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Endangered Species Act, 16 U.S.C. 1531 et seq. Before any such action is filed against property subject to... property subject to forfeiture under the Airborne Hunting Act, 16 U.S.C. 742j-1; Lacey Act, 18 U.S.C. 43-44; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Black Bass Act, 16 U.S.C. 851 et seq.; Marine...

  4. 25 CFR Appendix A to Subpart D - Cultural Resource and Environmental Requirements for the IRR Program

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... limited to: 1. 16 U.S.C. 1531, Endangered Species Act. 2. 16 U.S.C. 4601, Land and Water Conservation Fund Act (Section 6(f)). 3. 16 U.S.C. 661-667d, Fish and Wildlife Coordination Act. 4. 23 U.S.C. 138.... 10. 7 U.S.C. 4201, Farmland Protection Policy Act. 11. 50 CFR part 402, Endangered Species Act...

  5. 50 CFR 12.25 - Transfers in settlement of civil penalty claims.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... may be liable for civil penalty under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; or Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., may be given an opportunity to...

  6. Performance Engineering Research Institute SciDAC-2 Enabling Technologies Institute Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lucas, Robert

    2013-04-20

    Enhancing the performance of SciDAC applications on petascale systems had high priority within DOE SC at the start of the second phase of the SciDAC program, SciDAC-2, as it continues to do so today. Achieving expected levels of performance on high-end computing (HEC) systems is growing ever more challenging due to enormous scale, increasing architectural complexity, and increasing application complexity. To address these challenges, the University of Southern California?s Information Sciences Institute organized the Performance Engineering Research Institute (PERI). PERI implemented a unified, tripartite research plan encompassing: (1) performance modeling and prediction; (2) automatic performance tuning; and (3) performance engineeringmore » of high profile applications. Within PERI, USC?s primary research activity was automatic tuning (autotuning) of scientific software. This activity was spurred by the strong user preference for automatic tools and was based on previous successful activities such as ATLAS, which automatically tuned components of the LAPACK linear algebra library, and other recent work on autotuning domain-specific libraries. Our other major component was application engagement, to which we devoted approximately 30% of our effort to work directly with SciDAC-2 applications. This report is a summary of the overall results of the USC PERI effort.« less

  7. Usual source of care and the quality of primary care: a survey of patients in Guangdong province, China.

    PubMed

    Du, Zhicheng; Liao, Yu; Chen, Chien-Chou; Hao, Yuantao; Hu, Ruwei

    2015-07-31

    Usual source of care (USC) refers to the provider or place a patient consults when sick or in need of medical advice. No studies have been conducted in China to compare the quality of primary care provided with or without USC. The purpose of this study was to fill this gap in the literature by examining the quality of primary care provided between those having a USC and those without. Results of the study would provide implications for policymakers in terms of improving primary care performance in China, and help guide patients in their health care seeking behaviors. A cross-sectional survey with patients was conducted in Guangdong province of China, using the Chinese validated Primary Care Assessment Tool (PCAT). ANOVA was performed to compare the overall and ten domains of primary care quality for patients with and without USC. Multivariate analyses were used to assess the association between USC and quality of primary care attributes while controlling for sociodemographic and health care characteristics. The study added evidence that having a USC can provide higher quality of primary care to patients than those without a USC. Results of this study showed that the PCAT score associated with those having a USC was significantly higher than those not having a USC. Moreover, the study showed that having a usual provider of care was also independently and significantly associated with patients' satisfaction with care. This study added evidence that in China, patients with a USC reported higher quality of medical care experiences compared with those without a USC. The efforts to improve quality of care should include policies promoting USC.

  8. 78 FR 77198 - Notice of Final Federal Agency Actions on Proposed Highway in California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ...: 23 U.S.C. 139(l)(1), as amended by the Moving Ahead for Progress in the 21st Century Act (MAP-21...: Endangered Species Act (16 U.S.C. 1531-1544 and Section 1536), Marine Mammal Protection Act [16 U.S.C. 1361], Fish and Wildlife Coordination Act (16 U.S.C. 661-667(d)), Migratory Bird Treaty Act (16 U.S.C. 703-712...

  9. 12 CFR 109.103 - Civil money penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A...,375,000 12 U.S.C. 1820(k)(6)(A)(ii) Violation of Post Employment Restrictions 275,000 12 U.S.C. 1884...

  10. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  11. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  12. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  13. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  14. 47 CFR 1.736 - Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Complaints filed pursuant to 47 U.S.C. 271(d)(6)(B). (a) Where a complaint is filed pursuant to 47 U.S.C. 271... deadline contained in 47 U.S.C. 271(d)(6)(B) in the following manner: (1) The complainant shall so indicate... filed pursuant to 47 U.S.C. 271(d)(6)(B) will not be entertained by the Commission staff subsequent to...

  15. 7 CFR 400.130 - Notice requirements before offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., and 1002, or any other applicable statutory authority; (l) Any other rights or remedies available to... (5 U.S.C. 5584, 10 U.S.C. 2774, 32 U.S.C 716, or 5 U.S.C 8346(b)), or may request waiver in the case...

  16. 76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... collections are mandatory. FR 2030 and FR 2030a: (12 U.S.C. 222, 282, 248(a) and 321). FR 2056: (12 U.S.C. 287, 248(a) and (i)). FR 2086: (12 U.S.C. 287, 248(a) and (i)). FR 2086a: (12 U.S.C. 321, 287, 248(a)). FR... to obtain a benefit (12 U.S.C. 338a, and 12 CFR 208.22). Individual respondent data generally are not...

  17. 12 CFR 509.103 - Civil money penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Company Act Violation 32,500 12 U.S.C. 1467a(i)(3) Holding Company Act Violation 32,500 12 U.S.C. 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A) Change...

  18. 12 CFR 509.103 - Civil money penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Company Act Violation 32,500 12 U.S.C. 1467a(i)(3) Holding Company Act Violation 32,500 12 U.S.C. 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A) Change...

  19. 12 CFR 509.103 - Civil money penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Company Act Violation 32,500 12 U.S.C. 1467a(i)(3) Holding Company Act Violation 32,500 12 U.S.C. 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A) Change...

  20. 12 CFR 509.103 - Civil money penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Company Act Violation 32,500 12 U.S.C. 1467a(i)(3) Holding Company Act Violation 32,500 12 U.S.C. 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A) Change...

  1. Applications of the First-principles LDA+Usc Method to Spin-crossover Minerals: the NAL Phase and (Mg,Fe)CO3 ferromagnesite

    NASA Astrophysics Data System (ADS)

    Hsu, H.

    2016-12-01

    Spin crossover (SCO) in iron-bearing minerals has attracted tremendous attention in recent years, as SCO usually leads to anomalous changes of the elastic, conducting, and thermodynamic properties of these minerals. Possible geophysical effects of SCO have been anticipated as well. With the development of the local density approximation + self-consistent Hubbard U (LDA+Usc) method, first-principles calculations have elucidated SCO in many lower-mantle minerals. The success of LDA+Usc lies in its capability to correctly identify the ground state in a wide pressure range and to accurately determine the mechanism of SCO, including the transition pressure PT. In this talk, two recent LDA+Usc studies of SCO minerals are presented: the "new aluminous (NAL) phase" [1] and (Mg,Fe)CO3 ferromagnesite [2]. The former is considered as a main host of aluminum in the subducted basalt and may be related to the seismic heterogeneities, and the latter is believed to be the major carbon carrier in the Earth's lower mantle and play a key role in the deep carbon cycle. For both minerals, the abrupt change of iron quadrupole splitting and the volume/elastic anomalies accompanying the SCO obtained in our calculations are in great agreement with experiments. Our calculations also suggest that the spin transition pressure PT in the NAL phase is not very sensitive to temperature, due to its nearly degenerate low-spin (LS) states, in contrast with (Mg,Fe)O ferropericlase and (Mg,Fe)CO3 systems, in which PT significantly increases with temperature. By examining the overall performance of the LDA+Usc method in the NAL phase and ferromagnesite, along with our previous calculations for ferropericlase and Fe-bearing MgSiO3 bridgmanite [3-5], we have established LDA+Usc a highly reliable method to study iron-bearing minerals and related materials under high pressure. [1] H. Hsu, in preparation. [2] S.-C. Huang and H. Hsu, Phys. Rev. B (Rapid Comm.), in press. [3] H. Hsu and R. M. Wentzcovitch, Phys. Rev. B 90, 195205 (2014). [4] H. Hsu et al., Earth Planet. Sci. Lett. 359-360, 34 (2012). [5] H. Hsu et al., Phys. Rev. Lett. 106, 118501 (2011).

  2. 78 FR 4833 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... violating the International Emergency Economic Powers Act (50 U.S.C. 1701, et seq. (2000 & Supp. IV 2010... order issued under the International Emergency Economic Powers Act (50 U.S.C. 1701-1706); 18 U.S.C. 793... effect under the International Emergency Economic Powers Act (50 U.S.C. 1701, et seq. (2000 & Supp. IV...

  3. Factors associated with having a usual source of care in an ethnically diverse sample of Asian American adults.

    PubMed

    Chang, Eva; Chan, Kitty S; Han, Hae-Ra

    2014-09-01

    Despite significant population increases, how Asian Americans ethnic subgroups vary in having a usual source of care (USC) is poorly understood. To examine how having a USC varies among Asian American ethnic subgroups (Chinese, Filipinos, Japanese, Koreans, Vietnamese, and South Asians), and the potential factors influencing variation in having a USC. Data were from 2005 and 2009 California Health Interview Survey. Logistic regressions and pair-wise comparisons were used to compare odds of having a USC among Asian ethnic adults (18-64 y) and to examine ethnicity-specific associations with immigration-related factors (English proficiency, length of residence, and living in an ethnically concordant neighborhood) and key enabling (employment, income, insurance), predisposing (education), and need (health status) factors. Models also adjusted for other sociodemographic factors. Significant differences in the magnitude of the variation and factors influencing having a USC were found across Asian subgroups. Korean and Japanese adults had 52%-69% lower adjusted odds of having a USC compared with Chinese. Among all Asian subgroups, uninsured adults had 85%-94% lower adjusted odds of having a USC. Patterns of associations with USC and key factors varied by specific Asian subgroup. Patterns of associations for USC varied by Asian subgroup, although uninsurance persisted significantly across all subgroups. Persistent variation and heterogenous associations suggest that targeted, ethnicity-specific policies and outreach are needed to improve having a USC for Asian American ethnic adults.

  4. Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

    PubMed Central

    Cocco, Emiliano; Lopez, Salvatore; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L; Menderes, Gulden; Zammataro, Luca; Buza, Natalia; Hui, Pei; Wong, Serena; Zhao, Siming; Bai, Yalai; Rimm, David L; Ratner, Elena; Litkouhi, Babak; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Santin, Alessandro D

    2016-01-01

    Background: Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are common in USC and may therefore represent ideal therapeutic targets. Methods: Cyclin E1 expression was evaluated by immunohistochemistry (IHC) on 95 USCs. The efficacy of the cyclin-dependent kinase 2/9 inhibitor CYC065 was assessed on multiple primary USC cell lines with or without CCNE1 amplification. Cell-cycle analyses and knockdown experiments were performed to assess CYC065 targeting specificity. Finally, the in vitro and in vivo activity of CYC065, Taselisib (a PIK3CA inhibitor) and their combinations was tested on USC xenografts derived from CCNE1-amplified/pik3ca-mutated USCs. Results: We found that 89.5% of the USCs expressed CCNE1. CYC065 blocked cells in the G1 phase of the cell cycle and inhibited cell growth specifically in CCNE1-overexpressing USCs. Cyclin E1 knockdown conferred increased resistance to CYC065, whereas CYC065 treatment of xenografts derived from CCNE1-amplified USCs significantly reduced tumour growth. The combination of CYC065 and Taselisib demonstrated synergistic effect in vitro and was significantly more effective than single-agent treatment in decreasing tumour growth in xenografts of CCNE1-amplified/pik3ca-mutated USCs. Conclusions: Dual CCNE1/PIK3CA blockade may represent a novel therapeutic option for USC patients harbouring recurrent CCNE1-amplified/pi3kca-mutated tumours. PMID:27351214

  5. Usual source of care as a health insurance substitute for U.S. adults with diabetes?

    PubMed

    DeVoe, Jennifer E; Tillotson, Carrie J; Wallace, Lorraine S

    2009-06-01

    The purpose of this study was to examine the effects of health insurance and/or a usual source of care (USC) on receipt of diabetic-specific services and health care barriers for U.S. adults with diabetes. Secondary analyses of data from 6,562 diabetic individuals aged >or=18 years from the nationally representative Medical Expenditure Panel Survey from 2002 to 2005 were performed. Outcome measures included receipt of seven diabetic services plus five barriers to care. More than 84% of diabetic individuals in the U.S. had full-year coverage and a USC; 2.3% had neither one. In multivariate analyses, the uninsured with no USC had one-fifth the odds of receiving A1C screening (odds ratio 0.23 [95% CI 0.14-0.38]) and one-tenth the odds of a blood pressure check (0.08 [0.05-0.15]), compared with insured diabetic individuals with a USC. Similarly, being uninsured without a USC was associated with 5.5 times the likelihood of unmet medical needs (5.51 [3.49-8.70]) and three times more delayed urgent care (3.13 [1.53-6.38]) compared with being insured with a USC. Among the two groups with either insurance or a USC, diabetic individuals with only a USC had rates of diabetes-specific care more similar to those of insured individuals with a USC. In contrast, those with only insurance were closer to the reference group with fewer barriers to care. Insured diabetic individuals with a USC were better off than those with only a USC, only insurance, or neither one. Policy reforms must target both the financing and the delivery systems to achieve increased receipt of diabetes services and decreased barriers to care.

  6. The NASA-JPL advanced propulsion program

    NASA Technical Reports Server (NTRS)

    Frisbee, Robert H.

    1994-01-01

    The NASA Advanced Propulsion Concepts (APC) program at the Jet Propulsion Laboratory (JPL) consists of two main areas: The first involves cooperative modeling and research activities between JPL and various universities and industry; the second involves research at universities and industry that is directly supported by JPL. The cooperative research program consists of mission studies, research and development of ion engine technology using C-60 (Buckminsterfullerene) propellant, and research and development of lithium-propellant Lorentz-force accelerator (LFA) engine technology. The university/industry- supported research includes research (modeling and proof-of-concept experiments) in advanced, long-life electric propulsion, and in fusion propulsion. These propulsion concepts were selected primarily to cover a range of applications from near-term to far-term missions. For example, the long-lived pulsed-xenon thruster research that JPL is supporting at Princeton University addresses the near-term need for efficient, long-life attitude control and station-keeping propulsion for Earth-orbiting spacecraft. The C-60-propellant ion engine has the potential for good efficiency in a relatively low specific impulse (Isp) range (10,000 - 30,000 m/s) that is optimum for relatively fast (less than 100 day) cis-lunar (LEO/GEO/Lunar) missions employing near-term, high-specific mass electric propulsion vehicles. Research and modeling on the C-60-ion engine are currently being performed by JPL (engine demonstration), Caltech (C-60 properties), MIT (plume modeling), and USC (diagnostics). The Li-propellant LFA engine also has good efficiency in the modest Isp range (40,000 - 50,000 m/s) that is optimum for near-to-mid-term megawatt-class solar- and nuclear-electric propulsion vehicles used for Mars missions transporting cargo (in support of a piloted mission). Research and modeling on the Li-LFA engine are currently being performed by JPL (cathode development), Moscow Aviation Institute (engine testing), Thermacore (electrode development), as well as at MIT (plume modeling), and USC (diagnostics). Also, the mission performance of a nuclear-electric propulsion (NEP) Li-LFA Mars cargo vehicle is being modeled by JPL (mission analysis; thruster and power processor modeling) and the Rocketdyne Energy Technology and Engineering Center (ETEC) (power system modeling). Finally, the fusion propulsion research activities that JPL is supporting at Pennsylvania State University (PSU) and at Lawrenceville Plasma Physics (LPP) are aimed at far-term fast (less than 100 day round trip) piloted Mars missions and, in the very far term, interstellar missions.

  7. Preparing medical students to care for older adults: the impact of a Senior Mentor Program.

    PubMed

    Eleazer, G Paul; Wieland, Darryl; Roberts, Ellen; Richeson, Nancy; Thornhill, Joshua T

    2006-04-01

    To provide alternative training experiences for medical students to improve the competencies needed to provide care for older adults. Part of a comprehensive approach to integrating geriatric content at the University of South Carolina (USC) School of Medicine, the Senior Mentor Program (SMP) was launched in 2000. The SMP links pairs of students with older community volunteers in the spring of the first year. Students visit their mentors throughout medical school, and execute assignments that complement materials covered in the traditional curriculum. To evaluate the feasibility and efficacy of the SMP, the authors describe the program's operation and outputs, the extent to which undergraduate medical education at USC and the SMP meet the core competencies for care of older adults promulgated by the American Geriatrics Society (AGS), and analyze the coverage of geriatrics content from 2000 to 2005 at USC, as indicated by responses to the Medical School Graduation Questionnaire. From 2000 to 2005, 379 students enrolled in the SMP; 133 graduates of the classes of 2004 and 2005 have completed the SMP. Students and mentors indicated high acceptance and enthusiasm. The program has been maintained with minimal administrative burden. USC covered only half of AGS competencies before the SMP, but now covers 100%, with nearly a third met specifically through the SMP. USC graduates reporting inclusion of geriatrics throughout their four years of training rose from 66% in 2002 to 96% in 2004-05. The SMP has had a substantial impact on students' preparation for dealing with an aging patient population.

  8. Is a More Comprehensive Surgery Necessary in Patients With Uterine Serous Carcinoma?

    PubMed

    Touhami, Omar; Trinh, Xuan-Bich; Gregoire, Jean; Sebastianelli, Alexandra; Renaud, Marie-Claude; Grondin, Katherine; Plante, Marie

    2015-09-01

    Uterine serous carcinoma (USC) is an aggressive histologic subtype of endometrial cancer that shares similarities to serous ovarian cancer, with a propensity for spread to the upper abdomen, a high recurrence rate, and a poor prognosis. The aim of this study was to determine whether the traditional surgical staging procedure for endometrial cancer was adequate for USC or whether a more extensive surgery, similar to the staging procedure for ovarian cancer, needs to be performed. Specifically, the roles of omentectomy and sentinel lymph node (SLN) mapping were evaluated. We retrospectively identified cases of presumed clinical stage I USC at our institution from April 2005 to March 2014. Medical records were reviewed for the following information: age at diagnosis, preoperative imaging, operative findings, surgical procedure, and final histology with definitive International Federation of Gynecology and Obstetrics stage. A total of 39 patients with presumed clinical stage I USC were identified. According to the final pathology report, the surgical stage was as follows: 17 stage IA (44%), 8 stage IB (20%), 3 stage II (8%), 2 stage IIIA (5%), 6 stage IIIC1 (15%), 1 IIIC2 (3%), and 2 stage IVB (5%). Therefore, 14 patients (36%) were surgically upstaged, but none of the patients had their clinical disease upstaged by virtue of finding microscopic metastatic disease in an otherwise normal-looking omentum. Sentinel lymph node mapping was performed in 19 patients (42%). Sensitivity and negative predictive value of SLN mapping were 100% when at least 1 SLN was identified. The detection of microscopic disease in radiologically and clinically normal-appearing omentum seems to be rare in USC. Sentinel lymph node mapping seems to be valuable in the serous subtype of endometrial cancer. A less extensive surgery may be possible in patients with USC as it seems to provide the same information as a more extensive surgery.

  9. 76 FR 65206 - Agency Information Collection Activities: Small Vessel Reporting System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... States. SVRS is authorized by 8 U.S.C. 1103, 8 U.S.C. 1225, 8 CFR 235.1, 19 U.S.C. 1433, 19 U.S.C. 1498... Review: Approval of a new collection. Affected Public: Individuals. Estimated Number of Respondents: 10... Filed 10-19-11; 8:45 am] BILLING CODE 9111-14-P ...

  10. 40 CFR 123.27 - Requirements for enforcement authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... established under § 123.34. (Clean Water Act (33 U.S.C. 1251 et seq.), Safe Drinking Water Act (42 U.S.C. 300f et seq.), Clean Air Act (42 U.S.C. 7401 et seq.), Resource Conservation and Recovery Act (42 U.S.C.... 123.27 Section 123.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER...

  11. 40 CFR 123.27 - Requirements for enforcement authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... established under § 123.34. (Clean Water Act (33 U.S.C. 1251 et seq.), Safe Drinking Water Act (42 U.S.C. 300f et seq.), Clean Air Act (42 U.S.C. 7401 et seq.), Resource Conservation and Recovery Act (42 U.S.C.... 123.27 Section 123.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER...

  12. 40 CFR 123.27 - Requirements for enforcement authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... established under § 123.34. (Clean Water Act (33 U.S.C. 1251 et seq.), Safe Drinking Water Act (42 U.S.C. 300f et seq.), Clean Air Act (42 U.S.C. 7401 et seq.), Resource Conservation and Recovery Act (42 U.S.C.... 123.27 Section 123.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER...

  13. 40 CFR 123.27 - Requirements for enforcement authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... established under § 123.34. (Clean Water Act (33 U.S.C. 1251 et seq.), Safe Drinking Water Act (42 U.S.C. 300f et seq.), Clean Air Act (42 U.S.C. 7401 et seq.), Resource Conservation and Recovery Act (42 U.S.C.... 123.27 Section 123.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER...

  14. 48 CFR 241.102 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... authorized by— (A) 10 U.S.C. 2394 for energy, fuels, and energy production facilities for periods not to exceed 30 years; (B) 10 U.S.C. 2394a for renewable energy for periods not to exceed 25 years; (C) 10 U.S.C. 2689 for geothermal resources that result in energy production facilities; (D) 10 U.S.C. 2809 for...

  15. 48 CFR 241.102 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... authorized by— (A) 10 U.S.C. 2394 for energy, fuels, and energy production facilities for periods not to exceed 30 years; (B) 10 U.S.C. 2394a for renewable energy for periods not to exceed 25 years; (C) 10 U.S.C. 2689 for geothermal resources that result in energy production facilities; (D) 10 U.S.C. 2809 for...

  16. 78 FR 17995 - Agency Information Collection Activity Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... collections: 49 U.S.C. Section 5337--State of Good Repair Program 49 U.S.C. Section 5339--Bus and Bus... on a quarterly basis. The information submitted ensures FTA's compliance with applicable federal laws. Title: 49 U.S.C. Section 5339--Bus and Bus Facilities Program. Abstract: 49 U.S.C. 5339--Bus and Bus...

  17. 77 FR 76075 - Whistleblower Protection Advisory Committee (WPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... workers and employers, improving the investigative and enforcement process, improvements of regulations..., 49 U.S.C. 42121; the Sarbanes-Oxley Act, 18 U.S.C. 1514A; the Pipeline Safety Improvement Act, 49 U.S... Act, 6 U.S.C. 1142; the Consumer Product Safety Improvement Act, 15 U.S.C. 2087; Section 1558 of the...

  18. Development of Ultra-high Purity (UHP) Fe-Based Alloys with High Creep and Oxidation Resistance for A-USC Technology

    NASA Astrophysics Data System (ADS)

    Hamdani, Fethi; Das, Nishith K.; Shoji, Tetsuo

    2018-06-01

    The design of ultra-high purity (UHP) Fe-based model alloys for advanced ultra-supercritical (A-USC) technology is attempted in this work. Creep testing has been performed in air at 700 °C and a stress level of 150 MPa. Analysis of the fracture surface and cross section of the crept specimen was performed. To evaluate the oxidation resistance in A-USC conditions, oxidation testing was performed in supercritical water (SCW) at 700 °C and 25 MPa. Weight gain (WG) measurements and meticulous characterization of the oxide scale were carried out. Based on thermodynamics and density functional theory calculations, some reactive elements in the Fe-Cr-Ni system were designated to promote precipitation strengthening and to improve the hydrogen-accelerated oxidation resistance. The addition of a 2 wt pct Mo into Fe-22Cr-22Ni-0.6Nb wt pct-based matrix did not significantly improve the creep resistance. The addition of 0.26 wt pct Zr coupled with cold working was effective for improving creep properties. The Mo-modified model alloy showed almost the same WG value as SUS310, while the Zr-modified alloy showed a higher WG value. Meanwhile, a Cr-enriched continuous oxide layer was formed at the oxidation front of the Zr-modified alloy and SUS310S after exposure to SCW conditions.

  19. Development of Ultra-high Purity (UHP) Fe-Based Alloys with High Creep and Oxidation Resistance for A-USC Technology

    NASA Astrophysics Data System (ADS)

    Hamdani, Fethi; Das, Nishith K.; Shoji, Tetsuo

    2018-03-01

    The design of ultra-high purity (UHP) Fe-based model alloys for advanced ultra-supercritical (A-USC) technology is attempted in this work. Creep testing has been performed in air at 700 °C and a stress level of 150 MPa. Analysis of the fracture surface and cross section of the crept specimen was performed. To evaluate the oxidation resistance in A-USC conditions, oxidation testing was performed in supercritical water (SCW) at 700 °C and 25 MPa. Weight gain (WG) measurements and meticulous characterization of the oxide scale were carried out. Based on thermodynamics and density functional theory calculations, some reactive elements in the Fe-Cr-Ni system were designated to promote precipitation strengthening and to improve the hydrogen-accelerated oxidation resistance. The addition of a 2 wt pct Mo into Fe-22Cr-22Ni-0.6Nb wt pct-based matrix did not significantly improve the creep resistance. The addition of 0.26 wt pct Zr coupled with cold working was effective for improving creep properties. The Mo-modified model alloy showed almost the same WG value as SUS310, while the Zr-modified alloy showed a higher WG value. Meanwhile, a Cr-enriched continuous oxide layer was formed at the oxidation front of the Zr-modified alloy and SUS310S after exposure to SCW conditions.

  20. Development of a Mechanical Scanning Device With High-Frequency Ultrasound Transducer for Ultrasonic Capsule Endoscopy.

    PubMed

    Wang, Xingying; Seetohul, Vipin; Chen, Ruimin; Zhang, Zhiqiang; Qian, Ming; Shi, Zhehao; Yang, Ge; Mu, Peitian; Wang, Congzhi; Huang, Zhihong; Zhou, Qifa; Zheng, Hairong; Cochran, Sandy; Qiu, Weibao

    2017-09-01

    Wireless capsule endoscopy has opened a new era by enabling remote diagnostic assessment of the gastrointestinal tract in a painless procedure. Video capsule endoscopy is currently commercially available worldwide. However, it is limited to visualization of superficial tissue. Ultrasound (US) imaging is a complementary solution as it is capable of acquiring transmural information from the tissue wall. This paper presents a mechanical scanning device incorporating a high-frequency transducer specifically as a proof of concept for US capsule endoscopy (USCE), providing information that may usefully assist future research. A rotary solenoid-coil-based motor was employed to rotate the US transducer with sectional electronic control. A set of gears was used to convert the sectional rotation to circular rotation. A single-element focused US transducer with 39-MHz center frequency was used for high-resolution US imaging, connected to an imaging platform for pulse generation and image processing. Key parameters of US imaging for USCE applications were evaluated. Wire phantom imaging and tissue phantom imaging have been conducted to evaluate the performance of the proposed method. A porcine small intestine specimen was also used for imaging evaluation in vitro. Test results demonstrate that the proposed device and rotation mechanism are able to offer good image resolution ( [Formula: see text]) of the lumen wall, and they, therefore, offer a viable basis for the fabrication of a USCE device.

  1. 10 CFR 961.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General... means any person who has title to spent nuclear fuel or high-level radioactive waste. Purchaser means... (42 U.S.C. 2133, 2134) or who has title to spent nuclear fuel or high level radioactive waste and who...

  2. 50 CFR 11.2 - Scope of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... actions arising under the following laws and regulations issued thereunder: Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Bald Eagle Protection Act, 16 U.S.C. 668-668d; Endangered Species Act of 1973, 87 Stat. 884, 16 U.S.C. 1531 et seq.; and Marine Mammal Protection Act of...

  3. 50 CFR 11.2 - Scope of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... actions arising under the following laws and regulations issued thereunder: Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Bald Eagle Protection Act, 16 U.S.C. 668-668d; Endangered Species Act of 1973, 87 Stat. 884, 16 U.S.C. 1531 et seq.; and Marine Mammal Protection Act of...

  4. 50 CFR 11.2 - Scope of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... actions arising under the following laws and regulations issued thereunder: Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Bald Eagle Protection Act, 16 U.S.C. 668-668d; Endangered Species Act of 1973, 87 Stat. 884, 16 U.S.C. 1531 et seq.; and Marine Mammal Protection Act of...

  5. 50 CFR 11.2 - Scope of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... actions arising under the following laws and regulations issued thereunder: Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Bald Eagle Protection Act, 16 U.S.C. 668-668d; Endangered Species Act of 1973, 87 Stat. 884, 16 U.S.C. 1531 et seq.; and Marine Mammal Protection Act of...

  6. 50 CFR 11.2 - Scope of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... actions arising under the following laws and regulations issued thereunder: Lacey Act, 18 U.S.C. 43; Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq.; Bald Eagle Protection Act, 16 U.S.C. 668-668d; Endangered Species Act of 1973, 87 Stat. 884, 16 U.S.C. 1531 et seq.; and Marine Mammal Protection Act of...

  7. 50 CFR 12.23 - Administrative forfeiture proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Protection Act, 16 U.S.C. 668 et seq., or Airborne Hunting Act, 16 U.S.C. 742j-1, or any wildlife or plant subject to forfeiture under the Endangered Species Act, 16 U.S.C. 1531 et seq., or any fish, wildlife or plant subject to forfeiture under the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq., is...

  8. 50 CFR 12.23 - Administrative forfeiture proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Protection Act, 16 U.S.C. 668 et seq., or Airborne Hunting Act, 16 U.S.C. 742j-1, or any wildlife or plant subject to forfeiture under the Endangered Species Act, 16 U.S.C. 1531 et seq., or any fish, wildlife or plant subject to forfeiture under the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq., is...

  9. 50 CFR 12.23 - Administrative forfeiture proceedings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Protection Act, 16 U.S.C. 668 et seq., or Airborne Hunting Act, 16 U.S.C. 742j-1, or any wildlife or plant subject to forfeiture under the Endangered Species Act, 16 U.S.C. 1531 et seq., or any fish, wildlife or plant subject to forfeiture under the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq., is...

  10. 50 CFR 12.23 - Administrative forfeiture proceedings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Protection Act, 16 U.S.C. 668 et seq., or Airborne Hunting Act, 16 U.S.C. 742j-1, or any wildlife or plant subject to forfeiture under the Endangered Species Act, 16 U.S.C. 1531 et seq., or any fish, wildlife or plant subject to forfeiture under the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq., is...

  11. 15 CFR 922.152 - Prohibited or otherwise regulated activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Protection Act, as amended, (MMPA), 16 U.S.C. 1361 et seq., the Endangered Species Act, as amended, (ESA), 16 U.S.C. 1531 et seq., and the Migratory Bird Treaty Act, as amended, (MBTA), 16 U.S.C. 703 et seq... section 312 of the Federal Water Pollution Control Act, as amended, (FWPCA), 33 U.S.C. 1322 et seq.; (C...

  12. 50 CFR 12.23 - Administrative forfeiture proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Protection Act, 16 U.S.C. 668 et seq., or Airborne Hunting Act, 16 U.S.C. 742j-1, or any wildlife or plant subject to forfeiture under the Endangered Species Act, 16 U.S.C. 1531 et seq., or any fish, wildlife or plant subject to forfeiture under the Lacey Act Amendments of 1981, 16 U.S.C. 3371 et seq., is...

  13. 15 CFR 922.152 - Prohibited or otherwise regulated activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Protection Act, as amended, (MMPA), 16 U.S.C. 1361 et seq., the Endangered Species Act, as amended, (ESA), 16 U.S.C. 1531 et seq., and the Migratory Bird Treaty Act, as amended, (MBTA), 16 U.S.C. 703 et seq... section 312 of the Federal Water Pollution Control Act, as amended, (FWPCA), 33 U.S.C. 1322 et seq.; (C...

  14. 15 CFR 922.152 - Prohibited or otherwise regulated activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Protection Act, as amended, (MMPA), 16 U.S.C. 1361 et seq., the Endangered Species Act, as amended, (ESA), 16 U.S.C. 1531 et seq., and the Migratory Bird Treaty Act, as amended, (MBTA), 16 U.S.C. 703 et seq... section 312 of the Federal Water Pollution Control Act, as amended, (FWPCA), 33 U.S.C. 1322 et seq.; (C...

  15. 48 CFR 1552.235-71 - Treatment of confidential business information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Control Act (33 U.S.C. 1251, et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. 136 et seq.), the Federal Food, Drug, and Cosmetic Act... Toxic Substances Control Act (15 U.S.C. 2601 et seq.). EPA regulations on confidentiality of business...

  16. 48 CFR 1552.235-71 - Treatment of confidential business information.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Control Act (33 U.S.C. 1251, et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. 136 et seq.), the Federal Food, Drug, and Cosmetic Act... Toxic Substances Control Act (15 U.S.C. 2601 et seq.). EPA regulations on confidentiality of business...

  17. 48 CFR 1552.235-71 - Treatment of confidential business information.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Control Act (33 U.S.C. 1251, et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. 136 et seq.), the Federal Food, Drug, and Cosmetic Act... Toxic Substances Control Act (15 U.S.C. 2601 et seq.). EPA regulations on confidentiality of business...

  18. 48 CFR 1552.235-71 - Treatment of confidential business information.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Control Act (33 U.S.C. 1251, et seq.), the Safe Drinking Water Act (42 U.S.C. 300f et seq.), the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. 136 et seq.), the Federal Food, Drug, and Cosmetic Act... Toxic Substances Control Act (15 U.S.C. 2601 et seq.). EPA regulations on confidentiality of business...

  19. 11 CFR 100.11 - State (2 U.S.C. 431(12)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false State (2 U.S.C. 431(12)). 100.11 Section 100.11 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.11 State (2 U.S.C. 431(12)). State means each State of the United States, the District of...

  20. 78 FR 79241 - Assessment Framework and Organizational Restatement Regarding Preemption for Certain Regulations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... Under the Authority of 46 U.S.C. Chapter 32 G. Regulations Issued Pursuant to 46 U.S.C. Chapter 32 H. Preemption Restatement and Assessment Framework for Regulations Issued Under the Authority of 46 U.S.C. Chapter 33 I. Regulations Issued Pursuant to 46 U.S.C. Chapter 33 J. Preemption Restatement and Assessment...

  1. 29 CFR 1910.1200 - Hazard communication.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Fungicide, and Rodenticide Act (7 U.S.C. 136 et seq.), when subject to the labeling requirements of that Act... chemical substance or mixture as such terms are defined in the Toxic Substances Control Act (15 U.S.C. 2601..., and Cosmetic Act (21 U.S.C. 301 et seq.) or the Virus-Serum-Toxin Act of 1913 (21 U.S.C. 151 et seq...

  2. 15 CFR 990.24 - Compliance with other applicable laws and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... actions. (b) Natural Resources protection. When acting under this part, trustees must ensure compliance... Endangered Species Act of 1973, 16 U.S.C. 1531 et seq.; the Coastal Zone Management Act of 1972, 16 U.S.C... Mammal Protection Act, 16 U.S.C. 1361 et seq.; and the Archaeological Resources Protection Act, 16 U.S.C...

  3. 33 CFR 148.737 - What environmental statutes must an applicant follow?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... U.S.C. 469; Archeological Resources Protection Act (AHPA), 16 U.S.C. 470 aa-ll, et. seq.... seq.; Clean Water Act of 1977 (CWA), Pub. L. 95-217, 33 U.S.C. 1251, et. seq.; Coastal Barrier Resources Act (CBRA), Pub. L. 97-348, 16 U.S.C. 3510, et. seq.; Coastal Zone Management Act (CZMA), Pub. L...

  4. 15 CFR 990.24 - Compliance with other applicable laws and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... actions. (b) Natural Resources protection. When acting under this part, trustees must ensure compliance... Endangered Species Act of 1973, 16 U.S.C. 1531 et seq.; the Coastal Zone Management Act of 1972, 16 U.S.C... Mammal Protection Act, 16 U.S.C. 1361 et seq.; and the Archaeological Resources Protection Act, 16 U.S.C...

  5. 15 CFR 990.24 - Compliance with other applicable laws and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... actions. (b) Natural Resources protection. When acting under this part, trustees must ensure compliance... Endangered Species Act of 1973, 16 U.S.C. 1531 et seq.; the Coastal Zone Management Act of 1972, 16 U.S.C... Mammal Protection Act, 16 U.S.C. 1361 et seq.; and the Archaeological Resources Protection Act, 16 U.S.C...

  6. 15 CFR 990.24 - Compliance with other applicable laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... actions. (b) Natural Resources protection. When acting under this part, trustees must ensure compliance... Endangered Species Act of 1973, 16 U.S.C. 1531 et seq.; the Coastal Zone Management Act of 1972, 16 U.S.C... Mammal Protection Act, 16 U.S.C. 1361 et seq.; and the Archaeological Resources Protection Act, 16 U.S.C...

  7. 15 CFR 990.24 - Compliance with other applicable laws and regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... actions. (b) Natural Resources protection. When acting under this part, trustees must ensure compliance... Endangered Species Act of 1973, 16 U.S.C. 1531 et seq.; the Coastal Zone Management Act of 1972, 16 U.S.C... Mammal Protection Act, 16 U.S.C. 1361 et seq.; and the Archaeological Resources Protection Act, 16 U.S.C...

  8. 20 CFR 10.0 - What are the provisions of the FECA, in general?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... benefits to volunteers in the Civil Air Patrol (5 U.S.C. 8141), members of the Reserve Officers' Training Corps (5 U.S.C. 8140), Peace Corps Volunteers (5 U.S.C. 8142), Job Corps enrollees and Volunteers in... student employees (5 U.S.C. 5351 and 8144), certain law enforcement officers not employed by the United...

  9. 20 CFR 10.0 - What are the provisions of the FECA, in general?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... benefits to volunteers in the Civil Air Patrol (5 U.S.C. 8141), members of the Reserve Officers' Training Corps (5 U.S.C. 8140), Peace Corps Volunteers (5 U.S.C. 8142), Job Corps enrollees and Volunteers in... student employees (5 U.S.C. 5351 and 8144), certain law enforcement officers not employed by the United...

  10. 20 CFR 10.0 - What are the provisions of the FECA, in general?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... benefits to volunteers in the Civil Air Patrol (5 U.S.C. 8141), members of the Reserve Officers' Training Corps (5 U.S.C. 8140), Peace Corps Volunteers (5 U.S.C. 8142), Job Corps enrollees and Volunteers in... student employees (5 U.S.C. 5351 and 8144), certain law enforcement officers not employed by the United...

  11. 20 CFR 10.0 - What are the provisions of the FECA, in general?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... benefits to volunteers in the Civil Air Patrol (5 U.S.C. 8141), members of the Reserve Officers' Training Corps (5 U.S.C. 8140), Peace Corps Volunteers (5 U.S.C. 8142), Job Corps enrollees and Volunteers in... student employees (5 U.S.C. 5351 and 8144), certain law enforcement officers not employed by the United...

  12. 20 CFR 10.0 - What are the provisions of the FECA, in general?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... benefits to volunteers in the Civil Air Patrol (5 U.S.C. 8141), members of the Reserve Officers' Training Corps (5 U.S.C. 8140), Peace Corps Volunteers (5 U.S.C. 8142), Job Corps enrollees and Volunteers in... student employees (5 U.S.C. 5351 and 8144), certain law enforcement officers not employed by the United...

  13. 23 CFR 450.324 - Development and content of the transportation improvement program (TIP).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Metropolitan Transportation Planning and...), 49 U.S.C. 5305(d), and 49 U.S.C. 5339; (3) State planning and research projects funded under 23 U.S.C. 505 and 49 U.S.C. 5305(e); (4) At the discretion of the State and MPO, State planning and research...

  14. 23 CFR 450.324 - Development and content of the transportation improvement program (TIP).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Metropolitan Transportation Planning and...), 49 U.S.C. 5305(d), and 49 U.S.C. 5339; (3) State planning and research projects funded under 23 U.S.C. 505 and 49 U.S.C. 5305(e); (4) At the discretion of the State and MPO, State planning and research...

  15. 23 CFR 450.324 - Development and content of the transportation improvement program (TIP).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Metropolitan Transportation Planning and...), 49 U.S.C. 5305(d), and 49 U.S.C. 5339; (3) State planning and research projects funded under 23 U.S.C. 505 and 49 U.S.C. 5305(e); (4) At the discretion of the State and MPO, State planning and research...

  16. 23 CFR 450.324 - Development and content of the transportation improvement program (TIP).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Metropolitan Transportation Planning and...), 49 U.S.C. 5305(d), and 49 U.S.C. 5339; (3) State planning and research projects funded under 23 U.S.C. 505 and 49 U.S.C. 5305(e); (4) At the discretion of the State and MPO, State planning and research...

  17. 23 CFR 450.324 - Development and content of the transportation improvement program (TIP).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Metropolitan Transportation Planning and...), 49 U.S.C. 5305(d), and 49 U.S.C. 5339; (3) State planning and research projects funded under 23 U.S.C. 505 and 49 U.S.C. 5305(e); (4) At the discretion of the State and MPO, State planning and research...

  18. 46 CFR 388.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... such terms by 46 U.S.C. 2101. (g) Fraud means the intentional misrepresentation of a material fact or... Laws, (46 U.S.C. 12106); (2) The Passenger Services Act, section 8 of the Act of June 19, 1886 (46 App. U.S.C. 289); and (3) The Jones Act, section 27 of the Merchant Marine Act, 1920 (46 App. U.S.C. 883...

  19. 28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

  20. 46 CFR 388.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... such terms by 46 U.S.C. 2101. (g) Fraud means the intentional misrepresentation of a material fact or... Laws, (46 U.S.C. 12106); (2) The Passenger Services Act, section 8 of the Act of June 19, 1886 (46 App. U.S.C. 289); and (3) The Jones Act, section 27 of the Merchant Marine Act, 1920 (46 App. U.S.C. 883...

  1. 46 CFR 388.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... such terms by 46 U.S.C. 2101. (g) Fraud means the intentional misrepresentation of a material fact or... Laws, (46 U.S.C. 12106); (2) The Passenger Services Act, section 8 of the Act of June 19, 1886 (46 App. U.S.C. 289); and (3) The Jones Act, section 27 of the Merchant Marine Act, 1920 (46 App. U.S.C. 883...

  2. 46 CFR 388.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... such terms by 46 U.S.C. 2101. (g) Fraud means the intentional misrepresentation of a material fact or... Laws, (46 U.S.C. 12106); (2) The Passenger Services Act, section 8 of the Act of June 19, 1886 (46 App. U.S.C. 289); and (3) The Jones Act, section 27 of the Merchant Marine Act, 1920 (46 App. U.S.C. 883...

  3. 28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

  4. 28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

  5. 46 CFR 388.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... such terms by 46 U.S.C. 2101. (g) Fraud means the intentional misrepresentation of a material fact or... Laws, (46 U.S.C. 12106); (2) The Passenger Services Act, section 8 of the Act of June 19, 1886 (46 App. U.S.C. 289); and (3) The Jones Act, section 27 of the Merchant Marine Act, 1920 (46 App. U.S.C. 883...

  6. 28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

  7. 28 CFR 572.40 - Compassionate release under 18 U.S.C. 4205(g).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... 4205(g)) § 572.40 Compassionate release under 18 U.S.C. 4205(g). 18 U.S.C. 4205(g) was repealed... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Compassionate release under 18 U.S.C. 4205(g). 572.40 Section 572.40 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE...

  8. 75 FR 69870 - Delegation of Authority Under 18 U.S.C. 249

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Authority Under 18 U.S.C. 249 AGENCY: Department of Justice. ACTION: Final rule. SUMMARY: This rule amends 28 CFR part 0 to delegate the Attorney General's certification authority under 18 U.S.C. 249..., the Shepard-Byrd Act created a new federal hate crime statute to be codified at 18 U.S.C. 249. The...

  9. 76 FR 28058 - BOEMRE Information Collection Activity: 1010-0068, Unitization, Extension of a Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    .... Abstract: The Outer Continental Shelf (OCS) Lands Act, as amended (43 U.S.C. 1331 et seq. and 43 U.S.C... Independent Offices Appropriations Act (31 U.S.C. 9701), the Omnibus Appropriations Bill (Pub. L. 104-133, 110... respondents considered proprietary under the Freedom of Information Act (5 U.S.C. 552) and its implementing...

  10. Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects

    PubMed Central

    Chen, Long; Li, Lang; Xing, Fei; Peng, Jing; Peng, Kun; Wang, Yuanzheng

    2018-01-01

    Stem cell therapy is considered an optimistic approach to replace current treatments for cartilage defects. Recently, human urine-derived stem cells (hUSCs), which are isolated from the urine, are studied as a promising candidate for many tissue engineering therapies due to their multipotency and sufficient proliferation activities. However, it has not yet been reported whether hUSCs can be employed in cartilage defects. In this study, we revealed that induced hUSCs expressed chondrogenic-related proteins, including aggrecan and collagen II, and their gene expression levels were upregulated in vitro. Moreover, we combined hUSCs with hyaluronic acid (HA) and injected hUSCs-HA into a rabbit knee joint with cartilage defect. Twelve weeks after the injection, the histologic analyses (HE, toluidine blue, and Masson trichrome staining), immunohistochemistry (aggrecan and collagen II), and histologic grade of the sample indicated that hUSCs-HA could stimulate much more neocartilage formation compared with hUSCs alone, pure HA, and saline, which only induced the modest cartilage regeneration. In this study, we demonstrated that hUSCs could be a potential cell source for stem cell therapies to treat cartilage-related defects in the future. PMID:29765413

  11. Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology.

    PubMed

    Bharadwaj, Shantaram; Liu, Guihua; Shi, Yingai; Wu, Rongpei; Yang, Bin; He, Tongchuan; Fan, Yuxin; Lu, Xinyan; Zhou, Xiaobo; Liu, Hong; Atala, Anthony; Rohozinski, Jan; Zhang, Yuanyuan

    2013-09-01

    We sought to biologically characterize and identify a subpopulation of urine-derived stem cells (USCs) with the capacity for multipotent differentiation. We demonstrated that single USCs can expand to a large population with 60-70 population doublings. Nine of 15 individual USC clones expressed detectable levels of telomerase and have long telomeres. These cells expressed pericyte and mesenchymal stem cell markers. Upon induction with appropriate media in vitro, USCs differentiated into bladder-associated cell types, including functional urothelial and smooth muscle cell lineages. When the differentiated USCs were seeded onto a scaffold and subcutaneously implanted into nude mice, multilayered tissue-like structures formed consisting of urothelium and smooth muscle. Additionally, USCs were able to differentiate into endothelial, osteogenic, chondrogenic, adipogenic, skeletal myogenic, and neurogenic lineages but did not form teratomas during the 1-month study despite telomerase activity. USCs may be useful in cell-based therapies and tissue engineering applications, including urogenital reconstruction. © AlphaMed Press.

  12. 50 CFR 12.41 - Petition for restoration of proceeds.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... which has been forfeited under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1; or the Lacey Act Amendments of 1981... Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., and sold according to law, may file with the...

  13. 50 CFR 12.41 - Petition for restoration of proceeds.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... which has been forfeited under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1; or the Lacey Act Amendments of 1981... Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., and sold according to law, may file with the...

  14. 50 CFR 12.41 - Petition for restoration of proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... which has been forfeited under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1; or the Lacey Act Amendments of 1981... Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., and sold according to law, may file with the...

  15. 50 CFR 12.41 - Petition for restoration of proceeds.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... which has been forfeited under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1; or the Lacey Act Amendments of 1981... Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., and sold according to law, may file with the...

  16. 50 CFR 12.41 - Petition for restoration of proceeds.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... which has been forfeited under the Endangered Species Act, 16 U.S.C. 1531 et seq.; Eagle Protection Act, 16 U.S.C. 668 et seq.; Airborne Hunting Act, 16 U.S.C. 742j-1; or the Lacey Act Amendments of 1981... Marine Mammal Protection Act, 16 U.S.C. 1361 et seq., and sold according to law, may file with the...

  17. 77 FR 69377 - Delegation of Authority and Assignment of Responsibility to the Administrative Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... amended, 29 U.S.C. Sec. 2938; 29 CFR Part 37 (see 37.110-112); and (66) Any laws or regulation.... Authorities. This Order is issued under the authority of 5 U.S.C. 301 (Departmental Regulations); 29 U.S.C. 551 et seq. (Establishment of Department; Secretary; Seal); Reorganization Plan No. 6 1950 (5 U.S.C...

  18. 77 FR 751 - Federal Motor Vehicle Safety Standards; Matters Incorporated by Reference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... incorrectly cites 49 U.S.C. 30177. This section does not exist. The correct citation is 49 U.S.C. 30117... revising the citation to read as follows: Authority: 49 U.S.C. 322, 30111, 30115, 30117, and 30166... of the Director of the Federal Register under 5 U.S.C. 552(a) and 1 CFR part 51. To enforce any...

  19. 33 CFR 148.737 - What environmental statutes must an applicant follow?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; Archeological Resources Protection Act (AHPA), 16 U.S.C. 470 aa-ll, et. seq.; Architectural Barriers Act, 42 U.S... 1977 (CWA), Pub. L. 95-217, 33 U.S.C. 1251, et. seq.; Coastal Barrier Resources Act (CBRA), Pub. L. 97-348, 16 U.S.C. 3510, et. seq.; Coastal Zone Management Act (CZMA), Pub. L. 92-583, 16 U.S.C. 1451, et...

  20. 33 CFR 148.737 - What environmental statutes must an applicant follow?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...; Archeological Resources Protection Act (AHPA), 16 U.S.C. 470 aa-ll, et. seq.; Architectural Barriers Act, 42 U.S... 1977 (CWA), Pub. L. 95-217, 33 U.S.C. 1251, et. seq.; Coastal Barrier Resources Act (CBRA), Pub. L. 97-348, 16 U.S.C. 3510, et. seq.; Coastal Zone Management Act (CZMA), Pub. L. 92-583, 16 U.S.C. 1451, et...

  1. 78 FR 69447 - Importer of Controlled Substances; Notice of Application; GE Healthcare

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... radioactive diagnostic imaging agent utilized in the diagnosis of Parkinson's disease. Any bulk manufacturer...) of the Act (21 U.S.C. 952(a)(2)(B)) may, in the circumstances set forth in 21 U.S.C. 958(i), file... Administration, that the requirements for such registration pursuant to 21 U.S.C. 958(a); 21 U.S.C. 823(a); and...

  2. 49 CFR 1.66 - Delegations to Maritime Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., 1916, as amended (46 App. U.S.C. 801 et seq.); (b) Carry out the Merchant Marine Act, 1920, as amended (46 App. U.S.C. 861 et seq.), including the Ship Mortgage Act, 1920, as amended (46 App. U.S.C. 921 et seq.); (c) Carry out the Merchant Marine Act, 1928, as amended (46 App. U.S.C. 891 et seq.); (d) Carry...

  3. 49 CFR 1.66 - Delegations to Maritime Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., 1916, as amended (46 App. U.S.C. 801 et seq.); (b) Carry out the Merchant Marine Act, 1920, as amended (46 App. U.S.C. 861 et seq.), including the Ship Mortgage Act, 1920, as amended (46 App. U.S.C. 921 et seq.); (c) Carry out the Merchant Marine Act, 1928, as amended (46 App. U.S.C. 891 et seq.); (d) Carry...

  4. 29 CFR 5.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Amendments of 1965 (sec. 904, as added by sec. 2, 79 Stat. 928; 42 U.S.C. 299d(b)(4)). 28. Safe Drinking.... 6042(4); title I, sec. 111, 89 Stat. 491; 42 U.S.C. 6063(b)(19)). 48. National Energy Conservation..., 90 Stat. 1001; 42 U.S.C. 6708; also sec. 208, 90 Stat. 1008; 42 U.S.C. 6728). 50. Energy Conservation...

  5. 29 CFR 5.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Amendments of 1965 (sec. 904, as added by sec. 2, 79 Stat. 928; 42 U.S.C. 299d(b)(4)). 28. Safe Drinking.... 6042(4); title I, sec. 111, 89 Stat. 491; 42 U.S.C. 6063(b)(19)). 48. National Energy Conservation..., 90 Stat. 1001; 42 U.S.C. 6708; also sec. 208, 90 Stat. 1008; 42 U.S.C. 6728). 50. Energy Conservation...

  6. 29 CFR 5.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Amendments of 1965 (sec. 904, as added by sec. 2, 79 Stat. 928; 42 U.S.C. 299d(b)(4)). 28. Safe Drinking.... 6042(4); title I, sec. 111, 89 Stat. 491; 42 U.S.C. 6063(b)(19)). 48. National Energy Conservation..., 90 Stat. 1001; 42 U.S.C. 6708; also sec. 208, 90 Stat. 1008; 42 U.S.C. 6728). 50. Energy Conservation...

  7. 29 CFR 5.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Amendments of 1965 (sec. 904, as added by sec. 2, 79 Stat. 928; 42 U.S.C. 299d(b)(4)). 28. Safe Drinking.... 6042(4); title I, sec. 111, 89 Stat. 491; 42 U.S.C. 6063(b)(19)). 48. National Energy Conservation..., 90 Stat. 1001; 42 U.S.C. 6708; also sec. 208, 90 Stat. 1008; 42 U.S.C. 6728). 50. Energy Conservation...

  8. 19 CFR 191.174 - Derivatives manufactured under 19 U.S.C. 1313(a) or (b).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Derivatives manufactured under 19 U.S.C. 1313(a... Derivatives § 191.174 Derivatives manufactured under 19 U.S.C. 1313(a) or (b). When the basis for drawback under 19 U.S.C. 1313(p) is petroleum derivatives which were manufactured or produced in the United...

  9. 19 CFR 191.176 - Procedures for claims filed under 19 U.S.C. 1313(p).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Procedures for claims filed under 19 U.S.C. 1313(p... § 191.176 Procedures for claims filed under 19 U.S.C. 1313(p). (a) Applicability. The general procedures for filing drawback claims shall be applicable to claims filed under 19 U.S.C. 1313(p) unless...

  10. 19 CFR 191.176 - Procedures for claims filed under 19 U.S.C. 1313(p).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Procedures for claims filed under 19 U.S.C. 1313(p... § 191.176 Procedures for claims filed under 19 U.S.C. 1313(p). (a) Applicability. The general procedures for filing drawback claims shall be applicable to claims filed under 19 U.S.C. 1313(p) unless...

  11. 75 FR 25169 - Schedule of Fees Authorized by 49 U.S.C. 30141

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... [Docket No. NHTSA 2010-0035; Notice 1] RIN 2127-AK70 Schedule of Fees Authorized by 49 U.S.C. 30141 AGENCY...: This document proposes fees for Fiscal Year 2011 and until further notice, as authorized by 49 U.S.C...-562, since recodified at 49 U.S.C. 30141-47. The reader is referred to that notice for background...

  12. 11 CFR 102.14 - Names of political committees (2 U.S.C. 432(e) (4) and (5)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Names of political committees (2 U.S.C. 432(e... REGISTRATION, ORGANIZATION, AND RECORDKEEPING BY POLITICAL COMMITTEES (2 U.S.C. 433) § 102.14 Names of political committees (2 U.S.C. 432(e) (4) and (5)). (a) The name of each authorized committee shall include...

  13. 77 FR 3911 - Delegation of Authority and Assignment of Responsibility to the Assistant Secretary for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ...)-(d). (n) Federal Water Pollution Control Act, 33 U.S.C. 1367. (o) Toxic Substances Control Act, 15 U....S.C. 2651; the International Safe Container Act, 46 U.S.C. 80507; the Safe Drinking Water Act, 42 U... Environmental Response, Compensation and Liability Act of 1980, 42 U.S.C. 9610 (a)--(d); the Federal Water...

  14. Umbilical mesenchymal stromal cells provide intestinal protection through nitric oxide dependent pathways.

    PubMed

    Jensen, Amanda R; Drucker, Natalie A; Ferkowicz, Michael J; Markel, Troy A

    2018-04-01

    Umbilical-derived mesenchymal stromal cells (USCs) have shown promise in the protection of ischemic organs. We hypothesized that USCs would improve mesenteric perfusion, preserve intestinal histological architecture, and limit inflammation by nitric oxide-dependent mechanisms following intestinal ischemia/reperfusion (IR) injury. Adult wild-type C57BL/6J (WT) and endothelial nitric oxide synthase knock out (eNOS KO) mice were used: (1) WT IR + vehicle, (2) WT IR + USC, (3) eNOS KO IR + vehicle, and (4) eNOS KO IR + USC. Mice were anesthetized, and a midline laparotomy was performed. The superior mesenteric artery was clamped with a nonoccluding clamp for 60-min. Following IR, mice were treated with an injection of 250 μL phosphate buffered saline or 2 × 10 6 USCs suspended in 250-μL phosphate buffered saline solution. Mesenteric perfusion images were acquired using laser Doppler imaging. Perfusion was analyzed as a percentage of baseline. At 24 h, mice were euthanized, and intestines were harvested. Intestines were evaluated for injury, and data were analyzed using the Mann-Whitney or Kruskal-Wallis tests. Intestinal mesenteric perfusion was significantly improved in WT mice treated with USC therapy compared with eNOS KOs. Intestinal histological architecture was preserved with USC therapy in WT mice. However, in eNOS KO mice, this benefit was abolished. Finally, the presence of several cytokines and growth factors were significantly improved in WT mice compared with eNOS KO mice treated with USCs. The benefits of USC-mediated therapy following intestinal IR injury likely occur via nitric oxide-dependent pathways. Further studies are required to define the molecular mechanisms by which USCs activate endothelial nitric oxide synthase to bring about their protective effects. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Comprehending care in a medical home: a usual source of care and patient perceptions about healthcare communication.

    PubMed

    DeVoe, Jennifer E; Wallace, Lorraine S; Pandhi, Nancy; Solotaroff, Rachel; Fryer, George E

    2008-01-01

    To examine whether having a usual source of care (USC) is associated with positive patient perceptions of health care communication and to identify demographic factors among patients with a USC that are independently associated with differing reports of how patients perceive their involvement in health care decision making. Cross-sectional analyses of nationally representative data from the 2002 Medical Expenditure Panel Survey. Among adults with a health care visit in the past year (n = approximately 16,700), we measured independent associations between having a USC and patient perceptions of health care communication. Second, among respondents with a USC (n = approximately 18,000), we assessed the independent association between various demographic factors and indicators of patients' perceptions of their autonomy in making health care decisions. Approximately 78% of adults in the United States reported having a USC. Those with a USC were more likely to report that providers always listened to them, always explained things clearly, always showed respect, and always spent enough time with them. Patients who perceived higher levels of decision-making autonomy were non-Hispanic, had health insurance coverage, lived in rural areas, and had higher incomes. Patients with a USC were more likely to perceive positive health care interactions. Certain demographic factors among the subgroups of Medical Expenditure Panel Survey respondents with a USC were associated with patient perceptions of greater decision-making autonomy. Efforts to ensure universal access to a USC must be partnered with broader awareness and training of USC providers to engage patients from various demographic backgrounds equally when making health care decisions at the point of care.

  16. 16 CFR 0.4 - Laws administered.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (15 U.S.C. 18a), Petroleum Marketing Practices Act (15 U.S.C. 2801-2841), Comprehensive Smokeless..., 6201 & note, 6202-6212), Credit Repair Organizations Act (15 U.S.C. 1679-1679j), Children's Online...

  17. 76 FR 19901 - Supplemental Standards of Ethical Conduct for Members and Employees of the Securities and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... granted to OGE and to the Commission. These include 5 U.S.C. 7301; 5 U.S.C. App. (Ethics in Government Act... part 4401 continues to read as follows: Authority: 5 U.S.C. 7301; 5 U.S.C. App. (Ethics in Government... related to the issuance, purchase, sale, investment or trading of securities or futures on securities or a...

  18. 46 CFR 68.5 - Requirements for citizenship under 46 U.S.C. App. 883-1.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Requirements for citizenship under 46 U.S.C. App. 883-1... Engaging in Limited Coastwise Trade § 68.5 Requirements for citizenship under 46 U.S.C. App. 883-1. A corporation seeking to establish its citizenship under the Act of September 2, 1958 (46 U.S.C. App. 883-1...

  19. 46 CFR 68.5 - Requirements for citizenship under 46 U.S.C. App. 883-1.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Requirements for citizenship under 46 U.S.C. App. 883-1... Engaging in Limited Coastwise Trade § 68.5 Requirements for citizenship under 46 U.S.C. App. 883-1. A corporation seeking to establish its citizenship under the Act of September 2, 1958 (46 U.S.C. App. 883-1...

  20. 77 FR 50207 - Notice of Final Federal Agency Actions on Project: I-5: Glendale-Hugo Paving/Sexton Climbing Lane...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ...-1996a]; Farmland Protection Policy Act (FPPA) [7 U.S.C. 4201- 4209]. 7. Wetlands and Water Resources... Recovery Act (RCRA), [42 U.S.C. 6901- 6992(k)]. 9. Executive Orders: E.O. 11990 Protection of Wetlands; E.O..., as amended [16 U.S.C. 470(f) et seq.]; Archeological Resources Protection Act of 1977 [16 U.S.C. 470...

  1. 12 CFR 1022.71 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... same meaning as in 15 U.S.C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same... apply: (a) Adverse action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage...

  2. 12 CFR 1022.71 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... same meaning as in 15 U.S.C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same... apply: (a) Adverse action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage...

  3. 12 CFR 1022.71 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... same meaning as in 15 U.S.C. 1681a(r)(5). (i) Creditor has the same meaning as in 15 U.S.C. 1681a(r)(5). (j) Credit card has the same meaning as in 15 U.S.C. 1681a(r)(2). (k) Credit card issuer has the same... apply: (a) Adverse action has the same meaning as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage...

  4. 20 CFR 416.1236 - Exclusions from resources; provided by other statutes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Law 104-193 (42 U.S.C. 604(h)(4)). (21) Payments made to individuals who were captured and interned by.... 230, 42 U.S.C. 1751 et seq.) as amended by Pub. L. 90-302 (82 Stat. 117, 42 U.S.C. 1761(h)(3)). (6... Assistance and Real Property Acquisition Policies Act of 1970 (84 Stat. 1902, 42 U.S.C. 4636). (2) Payments...

  5. 7 CFR 3.91 - Adjusted civil monetary penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... obey Horse Protection Act disqualification, codified at 15 U.S.C. 1825(c), has a maximum of $4,300. (x... bids for the purpose of influencing a bid, codified at 42 U.S.C. 1786(h)(8)(H)(i), has a maximum of... 42 U.S.C. 1786(o)(1)(A) and 42 U.S.C. 1786(o)(4)(B), has a maximum of $11,000 for each violation...

  6. 20 CFR 416.1236 - Exclusions from resources; provided by other statutes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Law 104-193 (42 U.S.C. 604(h)(4)). (21) Payments made to individuals who were captured and interned by.... 230, 42 U.S.C. 1751 et seq.) as amended by Pub. L. 90-302 (82 Stat. 117, 42 U.S.C. 1761(h)(3)). (6... Assistance and Real Property Acquisition Policies Act of 1970 (84 Stat. 1902, 42 U.S.C. 4636). (2) Payments...

  7. 76 FR 55088 - Information Collection Activity: Unitization, Extension of a Collection; Submitted for Office of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... Continental Shelf (OCS) Lands Act, as amended (43 U.S.C. 1331 et seq. and 43 U.S.C. 1801 et seq.), authorizes... Independent Offices Appropriations Act (31 U.S.C. 9701), the Omnibus Appropriations Bill (Pub. L. 104-133, 110... according to the Freedom of Information Act (5 U.S.C. 552) and its implementing regulations (43 CFR 2), and...

  8. 40 CFR 16.12 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 1974 § 16.12 Specific exemptions. (a) Exemption under 5 U.S.C. 552a(k)(2)—(1) Systems of records... Personnel Security Files. EPA-46OCEFT/NEIC Master Tracking System. (2) Authority. Under 5 U.S.C. 552a(k)(2... U.S.C. 552a(k)(2): 5 U.S.C. 552a(c)(3); (d); (e)(1), (4)(G) and (4)(H); and (f)(2) through (5). EPA...

  9. 40 CFR 16.12 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 1974 § 16.12 Specific exemptions. (a) Exemption under 5 U.S.C. 552a(k)(2)—(1) Systems of records... Personnel Security Files. EPA-46OCEFT/NEIC Master Tracking System. (2) Authority. Under 5 U.S.C. 552a(k)(2... U.S.C. 552a(k)(2): 5 U.S.C. 552a(c)(3); (d); (e)(1), (4)(G) and (4)(H); and (f)(2) through (5). EPA...

  10. 40 CFR 16.12 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 1974 § 16.12 Specific exemptions. (a) Exemption under 5 U.S.C. 552a(k)(2)—(1) Systems of records... Personnel Security Files. EPA-46OCEFT/NEIC Master Tracking System. (2) Authority. Under 5 U.S.C. 552a(k)(2... U.S.C. 552a(k)(2): 5 U.S.C. 552a(c)(3); (d); (e)(1), (4)(G) and (4)(H); and (f)(2) through (5). EPA...

  11. 40 CFR 16.12 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 1974 § 16.12 Specific exemptions. (a) Exemption under 5 U.S.C. 552a(k)(2)—(1) Systems of records... Personnel Security Files. EPA-46OCEFT/NEIC Master Tracking System. (2) Authority. Under 5 U.S.C. 552a(k)(2... U.S.C. 552a(k)(2): 5 U.S.C. 552a(c)(3); (d); (e)(1), (4)(G) and (4)(H); and (f)(2) through (5). EPA...

  12. 40 CFR 16.12 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 1974 § 16.12 Specific exemptions. (a) Exemption under 5 U.S.C. 552a(k)(2)—(1) Systems of records... Personnel Security Files. EPA-46OCEFT/NEIC Master Tracking System. (2) Authority. Under 5 U.S.C. 552a(k)(2... U.S.C. 552a(k)(2): 5 U.S.C. 552a(c)(3); (d); (e)(1), (4)(G) and (4)(H); and (f)(2) through (5). EPA...

  13. 76 FR 46889 - Notice of Final Federal Agency Actions on Proposed Highway in Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... trestle to Harbor Island in Portland Canal, a distance of 0.7 miles. Hyder is 75 air miles northeast of....C. 4321-4351]; Federal-Aid Highway Act [23 U.S.C. 109]. 2. Air: Clean Air Act, 42 U.S.C. 7401-7671(q... Act (FPPA) [7 U.S.C. 4201-4209]. 7. Wetlands and Water Resources: Clean Water Act, 33 U.S.C. 1251...

  14. 32 CFR 37.105 - Does this part cover all types of instruments that 10 U.S.C. 2371 authorizes?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... covers only TIAs, some of which use the authority of 10 U.S.C. 2371 (see appendix B to this part). This part does not cover assistance instruments other than TIAs that use the authority of 10 U.S.C. 2371. It also does not cover acquisition agreements for prototype projects that use 10 U.S.C. 2371 authority...

  15. 75 FR 41278 - Notice of Final Federal Agency Actions on Proposed Highway in Idaho

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ...]; Fish and Wildlife Coordination Act [16 U.S.C. 661-667(d)]; Migratory Bird Treaty Act [16 U.S.C. 703-712... Preservation Act of 1974 [16 U.S.C. 469-469(c)]. Land: Section 4(f) of The Department of Transportation Act: [23 CFR 774]; Farmland Protection Policy Act (FPPA) [7 U.S.C. 4201-4209]; Solid Waste Disposal Act, as...

  16. 75 FR 3782 - Notice of Final Federal Agency Actions on Interstate 84 Highway in Idaho

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... Wildlife Coordination Act [16 U.S.C. 661- 667(d)]; Migratory Bird Treaty Act [16 U.S.C. 703-712]. 4...)]; Archeological and Historic Preservation Act [16 U.S.C. 469-469(c)]. 5. Land: Section 4(f) of The Department of... Protection Policy Act (FPPA) [7 U.S.C. 4201-4209]; Solid Waste Disposal Act, as amended by the Resource...

  17. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin.

    PubMed

    Kim, Yoon-Jin; Yoo, Sae Mi; Park, Hwan Hee; Lim, Hye Jin; Kim, Yu-Lee; Lee, Seunghee; Seo, Kwang-Won; Kang, Kyung-Sun

    2017-11-18

    Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Comparative Effectiveness of Usual Source of Care Approaches to Improve End-of-Life Outcomes for Children With Intellectual Disability.

    PubMed

    Lindley, Lisa C; Cozad, Melanie J

    2017-09-01

    Children with intellectual disability (ID) are at risk for adverse end-of-life outcomes including high emergency room utilization and hospital readmissions, along with low hospice enrollment. The objective of this study was to compare the effectiveness of usual source of care approaches to improve end-of-life outcomes for children with ID. We used longitudinal California Medicaid claims data. Children were included who were 21 years with fee-for-service Medicaid claims, died between January 1, 2007, and December 31, 2010, and had a moderate-to-profound ID diagnosis. End-of-life outcomes (i.e., hospice enrollment, emergency room utilization, hospital readmissions) were measured via claims data. Our treatments were usual source of care (USC) only vs. usual source of care plus targeted case management (USC plus TCM). Using instrumental variable analysis, we compared the effectiveness of treatments on end-of-life outcomes. Ten percent of children with ID enrolled in hospice, 73% used the emergency room, and 20% had three or more hospital admissions in their last year of life. USC plus TCM relative to USC only had no effect on hospice enrollment; however, it significantly reduced the probability of emergency room utilization (B = -1.29, P < 0.05) and hospital readmissions (B = -1.71, P < 0.001). Our findings demonstrated that USC plus TCM was more effective at improving end-of-life outcomes for children with ID. Further study of the extent of UCS and TCM involvement in reducing emergency room utilization and hospital readmissions at end of life is needed. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  19. Analyzing the risk of recurrence after mastectomy for DCIS: a new use for the USC/Van Nuys Prognostic Index.

    PubMed

    Kelley, Leah; Silverstein, Melvin; Guerra, Lisa

    2011-02-01

    Patients with ductal carcinoma in situ (DCIS) who are treated with mastectomy seldom recur locally or with metastatic disease. When patients with DCIS recur with invasive cancer, they are upstaged and their lives are threatened. We questioned whether histopathologic data could be used to predict these infrequent events. We reviewed a prospective database of 1,472 patients with pure DCIS. All patients were scored from 4 to 12 using the USC Van Nuys Prognostic Index, an algorithm based on DCIS size, nuclear grade, necrosis, margin width, and patient age. Probabilities of recurrence and death were calculated using the Kaplan-Meier method. A total of 496 patients with pure DCIS were treated with mastectomy. None received any form of postmastectomy adjuvant treatment. Average follow-up was 83 months. Eleven patients developed recurrences, all of whom scored 10-12 using the USC/VNPI. No patient who scored 4-9 recurred. All 11 patients who recurred had multifocal disease and comedo-type necrosis. The probability of disease recurrence after mastectomy for patients scoring 10-12 was 9.6% at 12 years, compared with 0% for those scoring 4-9. There was no difference in overall survival. There were no recurrences among mastectomy patients who scored 4-9 using the USC/VNPI. Patients scoring 10-12 were significantly more likely to develop recurrence after mastectomy. At risk were young patients with large, high-grade, and multifocal or multicentric tumors. For every 100 patients with USC/VNPI scores of 10-12, 10 patients will recur by 12 years and 2-3 will develop metastatic disease.

  20. 33 CFR 2.32 - High seas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false High seas. 2.32 Section 2.32... Jurisdictional Terms § 2.32 High seas. (a) For purposes of special maritime and territorial jurisdiction of the United States as defined in 18 U.S.C. 7, high seas means all waters seaward of the territorial sea...

  1. 33 CFR 2.32 - High seas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false High seas. 2.32 Section 2.32... Jurisdictional Terms § 2.32 High seas. (a) For purposes of special maritime and territorial jurisdiction of the United States as defined in 18 U.S.C. 7, high seas means all waters seaward of the territorial sea...

  2. 33 CFR 2.32 - High seas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false High seas. 2.32 Section 2.32... Jurisdictional Terms § 2.32 High seas. (a) For purposes of special maritime and territorial jurisdiction of the United States as defined in 18 U.S.C. 7, high seas means all waters seaward of the territorial sea...

  3. 33 CFR 2.32 - High seas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false High seas. 2.32 Section 2.32... Jurisdictional Terms § 2.32 High seas. (a) For purposes of special maritime and territorial jurisdiction of the United States as defined in 18 U.S.C. 7, high seas means all waters seaward of the territorial sea...

  4. 33 CFR 2.32 - High seas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false High seas. 2.32 Section 2.32... Jurisdictional Terms § 2.32 High seas. (a) For purposes of special maritime and territorial jurisdiction of the United States as defined in 18 U.S.C. 7, high seas means all waters seaward of the territorial sea...

  5. 78 FR 78507 - California High-Speed Rail Authority-Construction Exemption-In Fresno, Kings, Tulare, and Kern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ...)] California High-Speed Rail Authority--Construction Exemption--In Fresno, Kings, Tulare, and Kern Counties, CA By petition filed on September 26, 2013, California High-Speed Rail Authority (Authority), a state... 49 U.S.C. 10901 for authority to construct an approximately 114-mile high-speed passenger rail line...

  6. 29 CFR 24.100 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... given responsibility pursuant to the following federal statutes: Safe Drinking Water Act, 42 U.S.C. 300j.... 2622; Solid Waste Disposal Act, 42 U.S.C. 6971; Clean Air Act, 42 U.S.C. 7622; Energy Reorganization...

  7. 77 FR 65929 - Notice of Final Federal Agency Actions on the Tappan Zee Hudson River Crossing Project in New York

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... 21st Century Act (MAP-21), Pub. L. 112-141, Sec. 1308, 126 Stat. 405 (2012). Issued on: October 24... of 1966 [49 U.S.C. 303]. 4. Wildlife: Endangered Species Act [16 U.S.C. 1531-1544 and Section 1536], Marine Mammal Protection Act [16 U.S.C. 1361], Fish and Wildlife Coordination Act [16 U.S.C. 661-667(d...

  8. 20 CFR 645.255 - What nondiscrimination protections apply to participants in Welfare-to-Work programs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... regulations, including: (1) The Age Discrimination Act of 1975 (42 U.S.C. 6101 et seq.); (2) Section 504 of the Rehabilitation Act of 1973 (29 U.S.C. 794); (3) The Americans with Disabilities Act of 1990 (42 U.S.C. 12101 et seq.); and (4) Title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d et seq.). (b...

  9. 20 CFR 645.255 - What nondiscrimination protections apply to participants in Welfare-to-Work programs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulations, including: (1) The Age Discrimination Act of 1975 (42 U.S.C. 6101 et seq.); (2) Section 504 of the Rehabilitation Act of 1973 (29 U.S.C. 794); (3) The Americans with Disabilities Act of 1990 (42 U.S.C. 12101 et seq.); and (4) Title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d et seq.). (b...

  10. 20 CFR 645.255 - What nondiscrimination protections apply to participants in Welfare-to-Work programs?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... regulations, including: (1) The Age Discrimination Act of 1975 (42 U.S.C. 6101 et seq.); (2) Section 504 of the Rehabilitation Act of 1973 (29 U.S.C. 794); (3) The Americans with Disabilities Act of 1990 (42 U.S.C. 12101 et seq.); and (4) Title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d et seq.). (b...

  11. 20 CFR 645.255 - What nondiscrimination protections apply to participants in Welfare-to-Work programs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... regulations, including: (1) The Age Discrimination Act of 1975 (42 U.S.C. 6101 et seq.); (2) Section 504 of the Rehabilitation Act of 1973 (29 U.S.C. 794); (3) The Americans with Disabilities Act of 1990 (42 U.S.C. 12101 et seq.); and (4) Title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d et seq.). (b...

  12. 20 CFR 645.255 - What nondiscrimination protections apply to participants in Welfare-to-Work programs?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... regulations, including: (1) The Age Discrimination Act of 1975 (42 U.S.C. 6101 et seq.); (2) Section 504 of the Rehabilitation Act of 1973 (29 U.S.C. 794); (3) The Americans with Disabilities Act of 1990 (42 U.S.C. 12101 et seq.); and (4) Title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d et seq.). (b...

  13. 38 CFR 21.6523 - Entry and reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). 21.6523 Section 21.6523... reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). (a... pursue a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5), before...

  14. 38 CFR 21.6523 - Entry and reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). 21.6523 Section 21.6523... reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). (a... pursue a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5), before...

  15. 38 CFR 21.6523 - Entry and reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). 21.6523 Section 21.6523... reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). (a... pursue a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5), before...

  16. 38 CFR 21.6523 - Entry and reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). 21.6523 Section 21.6523... reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). (a... pursue a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5), before...

  17. 38 CFR 21.6523 - Entry and reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). 21.6523 Section 21.6523... reentry into a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5). (a... pursue a program of counseling and employment services under 38 U.S.C. 3104(a) (2) and (5), before...

  18. 77 FR 18671 - Implementation of OMB Guidance on Nonprocurement Debarment and Suspension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ....C. 1082, 1094, 1221e-3, and 3474, unless otherwise noted. Sec. 3485.12 What does this part do? (a)(1.... 2455, Pub. L. 103-355, 108 Stat. 3327 (31 U.S.C. 6101 note); 20 U.S.C. 1082, 1094, 1221e-3, and 3474.... 103-355, 108 Stat. 3327 (31 U.S.C. 6101 note); 20 U.S.C. 1082, 1094, 1221e-3, and 3474, unless...

  19. 45 CFR 97.12 - Which grants may be consolidated?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Delivered Meals for the Elderly, 42 U.S.C. 3030f. (6) Child Abuse and Neglect State Grants, 42 U.S.C. 5103(b... consolidated grant. (2) Alcohol and Drug Abuse and Mental Health Services, 42 U.S.C. 300x-300x-9. 2 2 See footnote 1 in § 97.12(a)(1). (3) Maternal and Child Health Services, 42 U.S.C. 701-709. 3 3 See footnote 1...

  20. 32 CFR Appendix A to Part 212 - Non-Federal Entities Having Statutory Authorization for Particular Support

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... American Red Cross. Boy Scouts Jamborees Section 2554 of title 10 U.S.C. Girl Scouts International Events... title 10 U.S.C. DoD Instruction 1015.9. Civil Air Patrol Section 9441 of title 10 U.S.C. Section 9442 of... Section 1058 of Public Law 109-163 (Note to Section 301 of title 5 U.S.C.). Section 8126 of Public Law 109...

  1. 32 CFR Appendix A to Part 212 - Non-Federal Entities Having Statutory Authorization for Particular Support

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... American Red Cross. Boy Scouts Jamborees Section 2554 of title 10 U.S.C. Girl Scouts International Events... title 10 U.S.C. DoD Instruction 1015.9. Civil Air Patrol Section 9441 of title 10 U.S.C. Section 9442 of... Section 1058 of Public Law 109-163 (Note to Section 301 of title 5 U.S.C.). Section 8126 of Public Law 109...

  2. 78 FR 52999 - Notice of Final Federal Agency Actions on Proposed Highway in Indiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... and 23 U.S.C. 128]. 4. Clean Air Act, 42 U.S.C. 7401-7671(q). 5. Section 4(f) of the Department of... that the FHWA and the USFWS have made decisions that are subject to 23 U.S.C. 139(l)(1) and are final... the Tier 1 decisions must have been filed by October 15, 2007, to avoid being barred under 23 U.S.C...

  3. 20 CFR 1002.103 - Are there any types of service in the uniformed services that an employee can perform that do not...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... uniformed service if he or she was ordered to or retained on active duty under: (i) 10 U.S.C. 688 (involuntary active duty by a military retiree); (ii) 10 U.S.C. 12301(a) (involuntary active duty in wartime); (iii) 10 U.S.C. 12301(g) (retention on active duty while in captive status); (iv) 10 U.S.C. 12302...

  4. 20 CFR 1002.103 - Are there any types of service in the uniformed services that an employee can perform that do not...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... uniformed service if he or she was ordered to or retained on active duty under: (i) 10 U.S.C. 688 (involuntary active duty by a military retiree); (ii) 10 U.S.C. 12301(a) (involuntary active duty in wartime); (iii) 10 U.S.C. 12301(g) (retention on active duty while in captive status); (iv) 10 U.S.C. 12302...

  5. 12 CFR 222.71 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S.C. 1681a(r)(1)(A). (l) Credit... as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same meaning as in 12 CFR 226.14(b... as in 15 U.S.C. 1681a(f). (h) Credit has the same meaning as in 15 U.S.C. 1681a(r)(5). (i) Creditor...

  6. 12 CFR 390.74 - Civil money penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... 1467a(i)(3) Holding Company Act Violation 32,500 12 U.S.C. 1467a(r)(1) Late/Inaccurate Reports—1st Tier 2,200 12 U.S.C. 1467a(r)(2) Late/Inaccurate Reports—2nd Tier 32,500 12 U.S.C. 1467a(r)(3) Late...) Violation of Law or Unsafe or Unsound Practice—3rd Tier 1,375,000 12 U.S.C. 1820(k)(6)(A)(ii) Violation of...

  7. 12 CFR 222.71 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... 1681a(r)(2). (k) Credit card issuer has the same meaning as in 15 U.S.C. 1681a(r)(1)(A). (l) Credit... as in 15 U.S.C. 1681a(k)(1)(A). (b) Annual percentage rate has the same meaning as in 12 CFR 226.14(b... as in 15 U.S.C. 1681a(f). (h) Credit has the same meaning as in 15 U.S.C. 1681a(r)(5). (i) Creditor...

  8. 45 CFR 96.16 - Applicability of title XVII of the Reconciliation Act (31 U.S.C. 7301-7305).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... health services block grant is not subject to any requirements of 31 U.S.C. 7301-7305. (d) The social services and low-income home energy assistance programs are subject only to 31 U.S.C. 7304. (e) The audit provisions of 31 U.S.C. 7305 have, in most cases, been overridden by the Single Audit Act. Pub. L. 98-502, 31...

  9. Race, gender, and language concordance in the primary care setting.

    PubMed

    Martin, Brian C; Shi, Leiyu; Ward, Ryan D

    2009-01-01

    The purpose of this paper is to examine race, gender and language concordance in terms of importance to primary care. The 2003 Medical Expenditure Panel Survey Household Component (MEPS) was used. Four distinguishing primary care attributes and selected measures were operationalized primarily from a sample subset that identified a usual source of care (USC): accessibility to USC; interface between primary care and specialist services; treatment decisions; and preventive services received from the USC. Bivariate and multivariate results are reported. Adjusting for covariates, the following items remained statistically significant: race--choosing primary care physician as USC, USC having office hours, and going to USC for new health problems; gender--choosing primary care physician as USC and USC having office hours; and language--lack of difficulty contacting the USC after hours. However, these items appear to be isolated cases rather than indicators that concordance plays a key role in determining primary care quality. Language barriers/communication issues are the only areas where improvement appears warranted. While the study has strong accessibility and interpersonal relationship measures, service coordination and comprehensiveness indicators are limited. The analyses' cross-sectional nature also poses a problem in drawing causal relationships and conclusive findings. Finally, sample size limitations preclude stratified analyses across racial/ethnic groups, an important consideration as the relationships between concordance and quality may vary across groups. This study indicates that more research is needed in this area to determine future resource allocation and policy direction. The unique contribution of the study is to suggest that race and gender concordance may not accurately predict primary health care quality.

  10. 46 CFR 7.1 - General purpose of boundary lines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... which are defined in 46 U.S.C. 2101(32); 46 U.S.C. 3301(7) requiring the inspection of seagoing motor... State of Washington; and 46 U.S.C. 8304, “Implementing the Officers' Competency Certificates Convention...

  11. 46 CFR 7.1 - General purpose of boundary lines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... which are defined in 46 U.S.C. 2101(32); 46 U.S.C. 3301(7) requiring the inspection of seagoing motor... State of Washington; and 46 U.S.C. 8304, “Implementing the Officers' Competency Certificates Convention...

  12. 12 CFR 509.103 - Civil money penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...,500 12 U.S.C. 1467a(r)(3) Late/Inaccurate Reports—3rd Tier 1,375,000 12 U.S.C. 1817(j)(16)(A) Change in Control—1st Tier 7,500 12 U.S.C. 1817(j)(16)(B) Change in Control—2nd Tier 37,500 12 U.S.C. 1817(j.... 4012a(f) Flood Insurance 1 385 2 135,000 1 Per day. 2 Per year. [56 FR 38306, Aug. 12, 1991, as amended...

  13. Usual source of care and the quality of medical care experiences: a cross-sectional survey of patients from a Taiwanese community.

    PubMed

    Tsai, Jenna; Shi, Leiyu; Yu, Wei-Lung; Lebrun, Lydie A

    2010-07-01

    This study used a recent patient survey to examine the relationship between having a usual source of care (USC) and the quality of ambulatory medical care experiences in Taiwan, where there is universal health insurance coverage. The study design was a cross-sectional survey of 879 patients in Taichung County, Taiwan. Children and adults visiting hospital-based physicians were included. Quality of care was measured using items from the Primary Care Assessment Tool (PCAT), representing 7 ambulatory medical care domains: first contact (ie, access and utilization), longitudinality (ie, ongoing care), coordination (ie, referrals and information systems), comprehensiveness (ie, services available and provided), family centeredness, community orientation, and cultural competence. USC was defined based on responses to 3 survey items from the PCAT. Having a USC was significantly associated with higher quality of medical care experiences. Specifically, having a USC was associated with improved accessibility and utilization, ongoing care, coordination of referrals, and healthcare providers' family centeredness and cultural competence. However, having a USC was not strongly related with comprehensiveness of services, coordination of information systems, or healthcare providers' community orientation. In a region with universal health insurance, patients with a USC reported higher quality of medical care experiences compared with those without a USC. Beyond the provision of health insurance coverage, efforts to improve quality of care should include policies promoting USC.

  14. Transabdominal Ultrasound Colonography for Detection of Colorectal Neoplasms: Initial Clinical Experience.

    PubMed

    Liu, Jin-Ya; Chen, Li-Da; Xu, Jian-Bo; Wu, Hui; Ye, Jin-Ning; Zhang, Xin-Hua; Xie, Xiao-Yan; Wang, Wei; Lu, Ming-De

    2017-10-01

    We investigated the feasibility of using ultrasound colonography (USC) to visualize the healthy colon and rectum and detect colorectal polyps. Eight healthy volunteers underwent USC after standard bowel preparation. The feasibility and image quality of USC in different segments were evaluated. Then, USC was conducted on eight patients with known colonic neoplasms using colonoscopy as the reference standard. For volunteers, USC examinations were successfully performed on four (50.0%) ascending, three (37.5%) transverse and eight (100%) descending colons, as well as all sigmoid colons and rectums. One of four (25.0%) ascending, two of eight (25.0%) descending and all sigmoid colons and rectums were well visualized and free of artifacts. For patients, colonoscopy revealed that eight patients had 17 neoplasms in the distal sigmoid colon and rectum, which included 3 lesions ≤5 mm, 3 lesions 6-9 mm and 11 lesions ≥10 mm. USC visualized 12 of 17 (70.6%) neoplasms. Lesion detection by USC was 0% (0/3), 33.3% (1/3) and 100% (11/11) for neoplasms ≤5, 6-9 mm and ≥10 mm in size. USC can visualize the sigmoid colon and rectum well and detect distal sigmoid and rectal neoplasms ≥10 mm in diameter. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  15. 25 CFR 39.143 - What is a small high school?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

  16. 25 CFR 39.143 - What is a small high school?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

  17. 25 CFR 39.143 - What is a small high school?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

  18. 25 CFR 39.143 - What is a small high school?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What is a small high school? 39.143 Section 39.143 Indians... Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is staffed with...

  19. 25 CFR 39.143 - What is a small high school?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

  20. 75 FR 16564 - High-Speed Intercity Passenger Rail (HSIPR) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... services to avoid shipping delays. Application forms are available at http://www.fra.dot.gov/Pages/2243..., and 501--Intercity Passenger Rail Service Corridor Capital Assistance (codified at 49 U.S.C. chapter... High Speed Rail Corridors and Intercity Passenger Rail Service.'' This document incorporates interim...

  1. The Effects of Health Insurance and a Usual Source of Care on a Child’s Receipt of Health Care

    PubMed Central

    Tillotson, Carrie J.; Wallace, Lorraine S.; Lesko, Sarah E.; Angier, Heather

    2012-01-01

    Introduction Recent health reforms will expand US children’s insurance coverage. Yet, disparities persist in access to pediatric care, even among the insured. We investigated the separate and combined effects of having health insurance and a usual source of care (USC) on children’s receipt of health care services. Methods We conducted secondary analysis of the nationally-representative 2002-2007 Medical Expenditure Panel Survey data from children (aged ≤18 years) who had at least one health care visit and needed any additional care, tests, or treatment in the preceding year (n=20,817). Results Approximately 88.1% of the study population had both a USC and insurance; 1.1% had neither one; 7.6% had a USC only, and 3.2% had insurance only. Children with both insurance and a USC had the fewest unmet needs. Among insured children, those with no USC had higher rates of unmet needs than those with a USC. Discussion Expansions in health insurance are essential; however, it is also important for every child to have a USC. New models of practice could help to concurrently achieve these goals. PMID:22920780

  2. 76 FR 13495 - Extending Provisions of the International Organizations Immunities Act to the Office of the High...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ... Bosnia and Herzegovina and the International Civilian Office in Kosovo Memorandum of March 8, 2011... the Office of the High Representative in Bosnia and Herzegovina and the International Civilian Office..., 22 U.S.C. 288), and the Extending Immunities to the Office of the High Representative in Bosnia and...

  3. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Coordination Act (16 U.S.C. 661 et seq.), the National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and...

  4. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Coordination Act (16 U.S.C. 661 et seq.), the National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and...

  5. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Coordination Act (16 U.S.C. 661 et seq.), the National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and...

  6. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Coordination Act (16 U.S.C. 661 et seq.), the National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and...

  7. 40 CFR 1502.25 - Environmental review and consultation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Coordination Act (16 U.S.C. 661 et seq.), the National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.), the Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.), and other environmental review laws and...

  8. 32 CFR 643.27 - Policy-Environmental considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Act of 1973 (16 U.S.C. 1531 et seq.). (e) Coastal Zone Management Act of 1972 (16 U.S.C. 1451). (f) Clean Air Act of 1970, as amended, (42 U.S.C. 1857), (AR 200-1, chapter 4). (g) Marine Protection...

  9. 32 CFR 643.27 - Policy-Environmental considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Act of 1973 (16 U.S.C. 1531 et seq.). (e) Coastal Zone Management Act of 1972 (16 U.S.C. 1451). (f) Clean Air Act of 1970, as amended, (42 U.S.C. 1857), (AR 200-1, chapter 4). (g) Marine Protection...

  10. 10 CFR Appendix A to Subpart A of... - Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec. 145 (42 U.S.C. 2165), Sec. 161 (42 U.S.C. 2201) A Appendix A to... to Subpart A of Part 710—Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141...

  11. 10 CFR Appendix A to Subpart A of... - Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec. 145 (42 U.S.C. 2165), Sec. 161 (42 U.S.C. 2201) A Appendix A to... to Subpart A of Part 710—Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141...

  12. 10 CFR Appendix A to Subpart A of... - Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec. 145 (42 U.S.C. 2165), Sec. 161 (42 U.S.C. 2201) A Appendix A to... to Subpart A of Part 710—Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141...

  13. 10 CFR Appendix A to Subpart A of... - Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec. 145 (42 U.S.C. 2165), Sec. 161 (42 U.S.C. 2201) A Appendix A to... to Subpart A of Part 710—Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141...

  14. 10 CFR Appendix A to Subpart A of... - Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141 (42 U.S.C. 2161), Sec. 145 (42 U.S.C. 2165), Sec. 161 (42 U.S.C. 2201) A Appendix A to... to Subpart A of Part 710—Selected Provisions of the Atomic Energy Act of 1954, as Amended, Sec. 141...

  15. A New Typology for State-Sponsored International Terrorism

    DTIC Science & Technology

    2011-12-01

    David C. Martin and John Walcott, Best Laid Plans: The inside Story of America’s War against Terrorism (New York: Simon and Schuster, 1988). 9...69 22 U.S.C. § 1691 70 22 U.S.C. § 2501 71 12 U.S.C. § 635 72 22 U.S.C. § 2780 73 Petra Minnerop, "Legal Status...D.C.: Congressional Research Service, 2010. Markey, Daniel. "A False Choice in Pakistan." Foreign Affairs 86, no. 4 (2007). Minnerop, Petra . "Legal

  16. A Framework for Synthesizing the United States Code in Support of Cyberspace Operations

    DTIC Science & Technology

    2016-03-01

    inter- title operations, it is unclear whether this de facto shift in the application of U.S.C. statutes is necessary. The U.S.C. has a limited number of...de facto shift in the application of U.S.C. statutes is necessary. The U.S.C. has a limited number of exclusionary distinctions de jure, which is...NATION STATE Though statecraft has progressed through numerous iterations over the course of human history, in the current post -colonial era, the

  17. 32 CFR 37.1035 - How do I know if my TIA uses the 10 U.S.C. 2371 authority and I must report additional data under...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false How do I know if my TIA uses the 10 U.S.C. 2371... TIA uses the 10 U.S.C. 2371 authority and I must report additional data under § 37.1030(b)? As explained in appendix B to this part, a TIA uses the authority of 10 U.S.C. 2371 and therefore must be...

  18. 40 CFR 19.4 - Penalty adjustment and table.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...,000/4,300 140,000/4,300 33 U.S.C. 1415(a) MARINE PROTECTION, RESEARCH, AND SANCTUARIES ACT (MPRSA) 50.... 300j-4(c) SDWA 25,000 27,500 32,500 37,500 42 U.S.C. 300j-6(b)(2) SDWA 25,000 25,000 27,500 32,500 42 U.... 6928(g) RCRA 25,000 27,500 32,500 37,500 42 U.S.C. 6928(h)(2) RCRA 25,000 27,500 32,500 37,500 42 U.S.C...

  19. 40 CFR 19.4 - Penalty adjustment and table.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...,000/4,300 140,000/4,300 33 U.S.C. 1415(a) MARINE PROTECTION, RESEARCH, AND SANCTUARIES ACT (MPRSA) 50.... 300j-4(c) SDWA 25,000 27,500 32,500 37,500 42 U.S.C. 300j-6(b)(2) SDWA 25,000 25,000 27,500 32,500 42 U.... 6928(g) RCRA 25,000 27,500 32,500 37,500 42 U.S.C. 6928(h)(2) RCRA 25,000 27,500 32,500 37,500 42 U.S.C...

  20. 37 CFR 251.60 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... affecting cable (17 U.S.C. 111), the making of ephemeral recordings (17 U.S.C. 112), certain digital audio transmissions (17 U.S.C. 114), the manufacture and distribution of phonorecords, including digital phonorecord...

  1. 37 CFR 251.60 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY... affecting cable (17 U.S.C. 111), the making of ephemeral recordings (17 U.S.C. 112), certain digital audio transmissions (17 U.S.C. 114), the manufacture and distribution of phonorecords, including digital phonorecord...

  2. Family perceptions of the usual source of care among children with asthma by race/ethnicity, language, and family income.

    PubMed

    Greek, April A; Kieckhefer, Gail M; Kim, Hyoshin; Joesch, Jutta M; Baydar, Nazli

    2006-01-01

    A usual source of care (USC) can serve as the foundation for good primary health care and is critical for children living with a chronic health condition. This study applies national data to the following objectives: (1) describe family reports of the presence and characteristics of the USC for children with asthma; (2) examine evidence of systematic differences in the USC for these children with asthma by race/ethnicity, English language proficiency in Hispanic respondents, and family income; and (3) conduct multivariate analysis adjusting for possible confounding factors to examine independent effects of race/ethnicity, language, and income. Data from the 1996-2000 Medical Expenditure Panel Survey (MEPS) were analyzed. Overall, 95% of children with asthma had a USC, with Spanish-speaking Hispanics least likely to report a USC (89%). There were significant differences in USC attributes by race/ethnicity, language, and income, with the largest differences by type of provider and accessibility. Hispanics with poor English language proficiency had the greatest accessibility barriers.

  3. Materials Performance in USC Steam Portland

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G.R. Holcomb; J. Tylczak; R. Hu

    2011-04-26

    Goals of the U.S. Department of Energy's Advanced Power Systems Initiatives include power generation from coal at 60% efficiency, which requires steam conditions of up to 760 C and 340 atm, co-called advanced ultrasupercritical (A-USC) steam conditions. A limitation to achieving the goal is a lack of cost-effective metallic materials that can perform at these temperatures and pressures. Some of the more important performance limitations are high-temperature creep strength, fire-side corrosion resistance, and steam-side oxidation resistance. Nickel-base superalloys are expected to be the materials best suited for steam boiler and turbine applications above about 675 C. Specific alloys of interestmore » include Haynes 230 and 282, Inconel 617, 625 and 740, and Nimonic 263. Further validation of a previously developed chromia evaporation model is shown by examining the reactive evaporation effects resulting from exposure of Haynes 230 and Haynes 282 to moist air environments as a function of flow rate and water content. These two alloys differ in Ti and Mn contents, which may form outer layers of TiO{sub 2} or Cr-Mn spinels. This would in theory decrease the evaporation of Cr{sub 2}O{sub 3} from the scale by decreasing the activity of chromia at the scale surface, and be somewhat self-correcting as chromia evaporation concentrates the Ti and Mn phases. The apparent approximate chromia activity was found for each condition and alloy that showed chromia evaporation kinetics. As expected, it was found that increasing the gas flow rate led to increased chromia evaporation and decreased chromia activity. However, increasing the water content in moist air increased the evaporation, but results were mixed with its effect on chromia activity.« less

  4. 7 CFR 2.49 - Administrator, Rural Housing Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... the Food, Conservation, and Energy Act of 2008 (7 U.S.C. 8791(b)(3)(A)). (13) In coordination with the...

  5. 7 CFR 2.49 - Administrator, Rural Housing Service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... the Food, Conservation, and Energy Act of 2008 (7 U.S.C. 8791(b)(3)(A)). (13) In coordination with the...

  6. 7 CFR 2.49 - Administrator, Rural Housing Service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... the Food, Conservation, and Energy Act of 2008 (7 U.S.C. 8791(b)(3)(A)). (13) In coordination with the...

  7. 7 CFR 2.49 - Administrator, Rural Housing Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (33 U.S.C. 1251 et seq.); (iii) Safe Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv... 1619(b)(3)(A) of the Food, Conservation, and Energy Act of 2008 (7 U.S.C. 8791(b)(3)(A)). (13) In...

  8. 15 CFR 923.32 - Lakeward or seaward boundary.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... United States of America, as approved by the Act of March 24, 1976 (48 U.S.C. 1681 note) or section 1 of... ownership under the Submerged Lands Act (48 U.S.C. 1301 et seq.), the Act of March 2, 1917 (48 U.S.C. 749...

  9. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Environmental Policy Act (43 U.S.C. 4321), the National Historic Preservation Act (16 U.S.C. 470), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978... or Federal agencies under, but not limited to, the Endangered Species Act, the National Historic...

  10. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Environmental Policy Act (43 U.S.C. 4321), the National Historic Preservation Act (16 U.S.C. 470), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978... or Federal agencies under, but not limited to, the Endangered Species Act, the National Historic...

  11. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Environmental Policy Act (43 U.S.C. 4321), the National Historic Preservation Act (16 U.S.C. 470), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978... or Federal agencies under, but not limited to, the Endangered Species Act, the National Historic...

  12. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Environmental Policy Act (43 U.S.C. 4321), the National Historic Preservation Act (16 U.S.C. 470), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978... or Federal agencies under, but not limited to, the Endangered Species Act, the National Historic...

  13. 32 CFR 285.2 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) National Security Agency/Central Security Service records, unless the records are exempt according to 50 U.S.C. 402. (c) Defense Intelligence Agency, National Reconnaissance Office, and National Geospatial-Intelligence Agency records, unless the records are exempt according to 50 U.S.C. 403-5e, 10 U.S.C. 424 and 455...

  14. 32 CFR 644.560 - Inspections of civilian component training facilities and other properties conveyed subject to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., the Secretary of Health, Education, and Welfare or its successor agencies (40 U.S.C. 484(k)(4)). The... deeds for property conveyed for airport purposes under 49 U.S.C. 1723 and 50 App. U.S.C. 1622g is the...

  15. 32 CFR 644.560 - Inspections of civilian component training facilities and other properties conveyed subject to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., the Secretary of Health, Education, and Welfare or its successor agencies (40 U.S.C. 484(k)(4)). The... deeds for property conveyed for airport purposes under 49 U.S.C. 1723 and 50 App. U.S.C. 1622g is the...

  16. 78 FR 12776 - Endangered and Threatened Species Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    .... SUPPLEMENTARY INFORMATION: Public Availability of Comments The Act (16 U.S.C. 1531 et seq.) prohibits activities... (5 U.S.C. 552a) and Freedom of Information Act (5 U.S.C. 552). Permit TE-022190 Applicant: Arizona... pupfish (Cyprinodon elegans) Devils River minnow (Dionda diaboli) Fountain darter (Etheostoma fonticola...

  17. 36 CFR 1211.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of Congress or Federal...

  18. 32 CFR 196.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of Congress or Federal...

  19. 45 CFR 2555.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of Congress or Federal...

  20. 38 CFR 23.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of Congress or Federal...

  1. 10 CFR 5.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and 855 of the Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of...

  2. 24 CFR 3.125 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Public Health Service Act (42 U.S.C. 295m, 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act of 1963 (29 U.S.C. 206); and any other Act of Congress or Federal...

  3. 34 CFR 106.6 - Effect of other requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Health Service Act (42 U.S.C. 292d and 298b-2); Title VII of the Civil Rights Act of 1964 (42 U.S.C. 2000e et seq.); the Equal Pay Act (29 U.S.C. 206 and 206(d)); and any other Act of Congress or...

  4. 77 FR 67276 - Yemen Sanctions Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... reference books, photocopies, credit reports, transcripts of statements, registered mail, insurance... authority of, inter alia, the International Emergency Economic Powers Act (50 U.S.C. 1701 et seq.) and the... International Emergency Economic Powers Act (50 U.S.C. 1701-1706), in Section 203 (50 U.S.C. 1702), authorizes...

  5. 5 CFR 2635.902 - Related statutes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... from a source other than the United States (18 U.S.C. 209). (j) The prohibition against gifts to superiors (5 U.S.C. 7351). (k) The prohibition against solicitation or receipt of gifts from specified... gifts and decorations (5 U.S.C. 7342). (n) [Reserved] (o) The prohibitions against certain political...

  6. 12 CFR 333.101 - Prior consent not required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Income Security Act of 1974 (26 U.S.C. 408), Self-Employed Retirement Plans established pursuant to the Self-Employed Individuals Retirement Act of 1962 (26 U.S.C. 401), Roth Individual Retirement Accounts... Prescription Drug Improvement, and Modernization Act of 2003 (26 U.S.C. 223), and other similar accounts...

  7. 12 CFR 333.101 - Prior consent not required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Income Security Act of 1974 (26 U.S.C. 408), Self-Employed Retirement Plans established pursuant to the Self-Employed Individuals Retirement Act of 1962 (26 U.S.C. 401), Roth Individual Retirement Accounts... Prescription Drug Improvement, and Modernization Act of 2003 (26 U.S.C. 223), and other similar accounts...

  8. 12 CFR 333.101 - Prior consent not required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Income Security Act of 1974 (26 U.S.C. 408), Self-Employed Retirement Plans established pursuant to the Self-Employed Individuals Retirement Act of 1962 (26 U.S.C. 401), Roth Individual Retirement Accounts... Prescription Drug Improvement, and Modernization Act of 2003 (26 U.S.C. 223), and other similar accounts...

  9. 12 CFR 333.101 - Prior consent not required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Income Security Act of 1974 (26 U.S.C. 408), Self-Employed Retirement Plans established pursuant to the Self-Employed Individuals Retirement Act of 1962 (26 U.S.C. 401), Roth Individual Retirement Accounts... Prescription Drug Improvement, and Modernization Act of 2003 (26 U.S.C. 223), and other similar accounts...

  10. 12 CFR 333.101 - Prior consent not required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Income Security Act of 1974 (26 U.S.C. 408), Self-Employed Retirement Plans established pursuant to the Self-Employed Individuals Retirement Act of 1962 (26 U.S.C. 401), Roth Individual Retirement Accounts... Prescription Drug Improvement, and Modernization Act of 2003 (26 U.S.C. 223), and other similar accounts...

  11. 7 CFR 235.7 - Records and reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... surveys. (Sec. 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); 93 Stat. 837, Pub. L. 96-108 (42 U.S.C. 1776); secs. 804, 816, 817 and 819, Pub. L...

  12. 7 CFR 235.11 - Other provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); secs. 805 and 819, Pub. L. 97-35, 95 Stat. 521-535 (42 U.S.C. 1773); sec. 7(a), Pub. L. 95-627...

  13. 7 CFR 235.7 - Records and reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... surveys. (Sec. 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); 93 Stat. 837, Pub. L. 96-108 (42 U.S.C. 1776); secs. 804, 816, 817 and 819, Pub. L...

  14. 7 CFR 235.11 - Other provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); secs. 805 and 819, Pub. L. 97-35, 95 Stat. 521-535 (42 U.S.C. 1773); sec. 7(a), Pub. L. 95-627...

  15. 7 CFR 235.7 - Records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... surveys. (Sec. 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); 93 Stat. 837, Pub. L. 96-108 (42 U.S.C. 1776); secs. 804, 816, 817 and 819, Pub. L...

  16. 7 CFR 235.7 - Records and reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... surveys. (Sec. 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); 93 Stat. 837, Pub. L. 96-108 (42 U.S.C. 1776); secs. 804, 816, 817 and 819, Pub. L...

  17. 7 CFR 235.11 - Other provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); secs. 805 and 819, Pub. L. 97-35, 95 Stat. 521-535 (42 U.S.C. 1773); sec. 7(a), Pub. L. 95-627...

  18. 7 CFR 235.11 - Other provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); secs. 805 and 819, Pub. L. 97-35, 95 Stat. 521-535 (42 U.S.C. 1773); sec. 7(a), Pub. L. 95-627...

  19. 7 CFR 235.7 - Records and reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... surveys. (Sec. 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); 93 Stat. 837, Pub. L. 96-108 (42 U.S.C. 1776); secs. 804, 816, 817 and 819, Pub. L...

  20. 7 CFR 235.11 - Other provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... 14, Pub. L. 95-166, 91 Stat. 1338 (42 U.S.C. 1776); sec. 7, Pub. L. 95-627, 92 Stat. 3621 (42 U.S.C. 1776); secs. 805 and 819, Pub. L. 97-35, 95 Stat. 521-535 (42 U.S.C. 1773); sec. 7(a), Pub. L. 95-627...

  1. 75 FR 77602 - Endangered and Threatened Species; 90-Day Finding on Petitions To Delist the Eastern Distinct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... a vertebrate species which interbreeds when mature (5 U.S.C. 553(e), 16 U.S.C.1533(b)(3)(A)). ESA... a vertebrate species which interbreeds when mature (16 U.S.C. 1532 (16)). Under section 4(a)(1) of...

  2. 78 FR 22770 - Immigration Benefits Business Transformation, Increment I; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ...: Authority: 5 U.S.C. 301, 552, 552a; 8 U.S.C. 1101, 1103, 1304, 1356, 1365b; 31 U.S.C. 9701; Pub. L. 107-296..., 1103, 1158, 1226, 1252, 1282; Title VII of Pub. L. 110-229; 8 CFR part 2. Subpart A--Asylum and...

  3. The effects of health insurance and a usual source of care on a child's receipt of health care.

    PubMed

    Devoe, Jennifer E; Tillotson, Carrie J; Wallace, Lorraine S; Lesko, Sarah E; Angier, Heather

    2012-01-01

    Although recent health care reforms will expand insurance coverage for U.S. children, disparities regarding access to pediatric care persist, even among the insured. We investigated the separate and combined effects of having health insurance and a usual source of care (USC) on children's receipt of health care services. We conducted secondary analysis of the nationally representative 2002-2007 Medical Expenditure Panel Survey data from children (≤ 18 years of age) who had at least one health care visit and needed any additional care, tests, or treatment in the preceding year (n = 20,817). Approximately 88.1% of the study population had both a USC and insurance; 1.1% had neither one; 7.6% had a USC only, and 3.2% had insurance only. Children with both insurance and a USC had the fewest unmet needs. Among insured children, those with no USC had higher rates of unmet needs than did those with a USC. Expansions in health insurance are essential; however, it is also important for every child to have a USC. New models of practice could help to concurrently achieve these goals. Copyright © 2012 National Association of Pediatric Nurse Practitioners. Published by Mosby, Inc. All rights reserved.

  4. 77 FR 38011 - Atlantic Highly Migratory Species; Atlantic Bluefin Tuna Fisheries

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    .... 110210132-1275-02] RIN 0648-XC055 Atlantic Highly Migratory Species; Atlantic Bluefin Tuna Fisheries AGENCY... northern area fishery for large medium and giant Atlantic bluefin tuna (BFT) for the remainder of 2012... INFORMATION: Regulations implemented under the authority of the Atlantic Tunas Convention Act (16 U.S.C. 971...

  5. 77 FR 31546 - Atlantic Highly Migratory Species; Atlantic Bluefin Tuna Fisheries

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    .... 110210132-1275-02] RIN 0648-XC035 Atlantic Highly Migratory Species; Atlantic Bluefin Tuna Fisheries AGENCY... tuna (BFT) for the remainder of 2012. Fishing for, retaining, possessing, or landing BFT in the... authority of the Atlantic Tunas Convention Act (16 U.S.C. 971 et seq.) and the Magnuson-Stevens Fishery...

  6. 24 CFR 55.1 - Purpose and basic responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... part 58. (b) Under section 202(a) of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4106(a...) Any critical action located in a coastal high hazard area; or (3) Any non-critical action located in a coastal high hazard area, unless the action is designed for location in a coastal high hazard area or is a...

  7. 24 CFR 55.1 - Purpose and basic responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... part 58. (b) Under section 202(a) of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4106(a...) Any critical action located in a coastal high hazard area; or (3) Any non-critical action located in a coastal high hazard area, unless the action is designed for location in a coastal high hazard area or is a...

  8. 24 CFR 55.1 - Purpose and basic responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... part 58. (b) Under section 202(a) of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4106(a...) Any critical action located in a coastal high hazard area; or (3) Any non-critical action located in a coastal high hazard area, unless the action is designed for location in a coastal high hazard area or is a...

  9. 24 CFR 55.1 - Purpose and basic responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... part 58. (b) Under section 202(a) of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4106(a...) Any critical action located in a coastal high hazard area; or (3) Any non-critical action located in a coastal high hazard area, unless the action is designed for location in a coastal high hazard area or is a...

  10. 75 FR 20582 - Record of Decision: Final Environmental Impact Statement for Decommissioning and/or Long-Term...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-20

    ... storage tanks and facilities used in the solidification of high-level radioactive waste, and any material... Act (Pub. L. 96-368, 42 U.S.C. 2021a). The WVDP Act requires DOE to demonstrate that the liquid high... take the following actions: 1. Solidify high-level radioactive waste by vitrification or such other...

  11. Toward a 21st-Century High School: An Iterative Quest

    ERIC Educational Resources Information Center

    Dwyer, David C.

    2013-01-01

    Well over one million high school students drop out of U.S. high schools each year. The human and financial tolls are startling and cannot be sustained in an era when the country is looking for means to remain globally competitive. What would it take to dramatically reduce the problem? USC's Rossier School of Education helped found an independent…

  12. Microbial keratitis in los angeles: the doheny eye institute and the los angeles county hospital experience.

    PubMed

    Sand, Daniel; She, Rosemary; Shulman, Ira A; Chen, David S; Schur, Mathew; Hsu, Hugo Y

    2015-05-01

    To evaluate the spectrum and antibiotic susceptibility panel of infectious keratitis at a major tertiary care referral eye center and a major county hospital in Southern California. Retrospective case series. All cultured infectious keratitis cases from July 1, 2008, through December 31, 2012, from the Doheny Eye Institute (DEI) and the Los Angeles County + University of Southern California Medical Center (LAC+USC) were evaluated. Microbiology records were reviewed retrospectively. Microbial isolates as well as antibiotic susceptibility patterns were analyzed. One hundred eighty-four (63%) of 290 cases showed positive culture results at DEI and 152 (82%) of 186 cases showed positive culture results at LAC+USC. Gram-positive pathogens were found to be the most common at both DEI (70%) and LAC+USC (68%), with coagulase-negative Staphylococcus being the most common gram-positive organism (58% at DEI and 44% at LAC+USC). Pseudomonas aeruginosa was the most common gram-negative organism (57% at DEI and 43% at LAC+USC). Ciprofloxacin and levofloxacin susceptibility for all tested pathogens was 73% at DEI and 81% at LAC+USC (P = 0.16). Oxacillin-resistant Staphylococcus aureus (ORSA) was found in 42% of cases at DEI and in 45% of cases at LAC+USC (P = 1.00). There is no significant difference in the spectrum of pathogens or antibiotic susceptibility of pathogens at DEI versus LAC+USC, and ORSA was found in approximately half of all S. aureus samples. Copyright © 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  13. 7 CFR 1794.2 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... review procedures required by law, or by RUS practice including but not limited to: (1) Endangered Species Act of 1973 (16 U.S.C. 1531 et seq.); (2) The National Historic Preservation Act (16 U.S.C. 470 et seq.); (3) Farmland Protection Policy Act (7 U.S.C. 4201 et seq.); (4) E.O. 11593, Protection and...

  14. 77 FR 22006 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... Members do not input the capacity in which they are acting (principal, agent, or riskless principal) into... otherwise violative trading activity. \\7\\ 15 U.S.C. 78s(b)(1). \\8\\ 15 U.S.C. 78f(b). \\9\\ 15 U.S.C. 78f(b)(5...

  15. 16 CFR 1145.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commission establishes rules which provide that risks of injury associated with consumer products that could... (FHSA) (15 U.S.C. 1261-1274), the Poison Prevention Packaging Act of 1970 (PPPA) (15 U.S.C. 1471-1476... Safety Act (CPSA) (15 U.S.C. 2051-2081). Section 30(d) of the CPSA, as amended, provides that a risk of...

  16. 7 CFR 2.47 - Administrator, Rural Utilities Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... U.S.C. 9601 et seq.). (13) Administer the Distance Learning and Medical Link Programs (7 U.S.C... access requests and orders; compliance with Federal health and safety standards and wage and labor... (42 U.S.C. 9604(i)(11)), with respect to the reduction of exposure to significant risk to human health...

  17. 75 FR 51083 - Office of Clinical and Preventive Services Maternal and Child Health Program: Project Choices...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... defined by 25 U.S.C. 1603(d); A Tribal organization as defined by 25 U.S.C. 1603(e); or an Urban Indian.... 25 U.S.C. 1603(d). Tribal organization means the elected governing body or any legally established.... 1603(e). [[Page 51085

  18. 38 CFR Appendix A to Subpart E of... - Statutory Provisions to Which This Subpart Applies

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... This Subpart Applies 1. Approval of educational institutions (38 U.S.C. 104). 2. Space and office... establishment, expansion, and improvement of veterans' cemeteries (38 U.S.C. 2408). 8. Vocational Rehabilitation.... Space and office facilities for representatives of recognized national organizations (38 U.S.C. 5902(a...

  19. 38 CFR Appendix A to Subpart E of... - Statutory Provisions to Which This Subpart Applies

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... This Subpart Applies 1. Approval of educational institutions (38 U.S.C. 104). 2. Space and office... establishment, expansion, and improvement of veterans' cemeteries (38 U.S.C. 2408). 8. Vocational Rehabilitation.... Space and office facilities for representatives of recognized national organizations (38 U.S.C. 5902(a...

  20. 38 CFR Appendix A to Subpart E of... - Statutory Provisions to Which This Subpart Applies

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... This Subpart Applies 1. Approval of educational institutions (38 U.S.C. 104). 2. Space and office... establishment, expansion, and improvement of veterans' cemeteries (38 U.S.C. 2408). 8. Vocational Rehabilitation.... Space and office facilities for representatives of recognized national organizations (38 U.S.C. 5902(a...

  1. 38 CFR Appendix A to Subpart E of... - Statutory Provisions to Which This Subpart Applies

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... This Subpart Applies 1. Approval of educational institutions (38 U.S.C. 104). 2. Space and office... establishment, expansion, and improvement of veterans' cemeteries (38 U.S.C. 2408). 8. Vocational Rehabilitation.... Space and office facilities for representatives of recognized national organizations (38 U.S.C. 5902(a...

  2. 38 CFR Appendix A to Subpart E of... - Statutory Provisions to Which This Subpart Applies

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... This Subpart Applies 1. Approval of educational institutions (38 U.S.C. 104). 2. Space and office... establishment, expansion, and improvement of veterans' cemeteries (38 U.S.C. 2408). 8. Vocational Rehabilitation.... Space and office facilities for representatives of recognized national organizations (38 U.S.C. 5902(a...

  3. 48 CFR 22.1502 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Prohibition of Acquisition of Products Produced by Forced or Indentured Child Labor 22.1502 Policy. Agencies must take appropriate action to enforce the laws... or in part by forced or indentured child labor (19 U.S.C. 1307, 29 U.S.C. 201, et seq., and 41 U.S.C...

  4. 15 CFR 904.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-2413; (4) Antarctic Marine Living Resources Convention Act of 1984, 16 U.S.C. 2431-2444; (5) Antarctic.... 1801-1882; (22) Marine Mammal Protection Act of 1972, 16 U.S.C. 1361-1407; (23) National Marine... Fisheries Convention Act of 1995, 16 U.S.C. 5601-5612; (27) Ocean Thermal Energy Conversion Act of 1980, 42...

  5. 11 CFR 100.26 - Public communication (2 U.S.C. 431(22)).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Public communication (2 U.S.C. 431(22)). 100.26...) General Definitions § 100.26 Public communication (2 U.S.C. 431(22)). Public communication means a communication by means of any broadcast, cable, or satellite communication, newspaper, magazine, outdoor...

  6. 32 CFR 536.17 - Single-service claims responsibility (DODD 5515.8 and DODD 5515.9).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... U.S.C. 2734); (2) MCA (10 U.S.C. 2733); (3) Status of Forces Agreements (10 U.S.C. 2734a and 2734b); (4) NATO SOFA (4 U.S.T. 1792, Treaties and International Acts Series (T.I.A.S.) 2846) and other...

  7. 32 CFR 536.17 - Single-service claims responsibility (DODD 5515.8 and DODD 5515.9).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... U.S.C. 2734); (2) MCA (10 U.S.C. 2733); (3) Status of Forces Agreements (10 U.S.C. 2734a and 2734b); (4) NATO SOFA (4 U.S.T. 1792, Treaties and International Acts Series (T.I.A.S.) 2846) and other...

  8. 31 CFR 8.3 - Conference and practice requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... issued under the Arms Export Control Act (22 U.S.C. 2778); (d) 27 CFR part 178, subpart E, with respect to proceedings concerning licenses issued under the Gun Control Act of 1968 (18 U.S.C. Chapter 44... under the Organized Crime Control Act of 1970 (18 U.S.C. Chapter 40). ...

  9. 31 CFR 8.3 - Conference and practice requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... issued under the Arms Export Control Act (22 U.S.C. 2778); (d) 27 CFR part 178, subpart E, with respect to proceedings concerning licenses issued under the Gun Control Act of 1968 (18 U.S.C. Chapter 44... under the Organized Crime Control Act of 1970 (18 U.S.C. Chapter 40). ...

  10. 31 CFR 8.3 - Conference and practice requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... issued under the Arms Export Control Act (22 U.S.C. 2778); (d) 27 CFR part 178, subpart E, with respect to proceedings concerning licenses issued under the Gun Control Act of 1968 (18 U.S.C. Chapter 44... under the Organized Crime Control Act of 1970 (18 U.S.C. Chapter 40). ...

  11. 31 CFR 8.3 - Conference and practice requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... issued under the Arms Export Control Act (22 U.S.C. 2778); (d) 27 CFR part 178, subpart E, with respect to proceedings concerning licenses issued under the Gun Control Act of 1968 (18 U.S.C. Chapter 44... under the Organized Crime Control Act of 1970 (18 U.S.C. Chapter 40). ...

  12. 32 CFR 750.13 - Claims: Single service responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Foreign Claims Act (10 U.S.C. 2734); (2) Military Claims Act (10 U.S.C. 2733); (3) International... international agreement; (4) NATO Status of Forces Agreement (4 UST 1792, TIAS 2846) and other similar... other provision of law; (7) Federal Claims Collection Act (31 U.S.C. Sections 3701, 3702, and 3711...

  13. 32 CFR 750.13 - Claims: Single service responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Foreign Claims Act (10 U.S.C. 2734); (2) Military Claims Act (10 U.S.C. 2733); (3) International... international agreement; (4) NATO Status of Forces Agreement (4 UST 1792, TIAS 2846) and other similar... other provision of law; (7) Federal Claims Collection Act (31 U.S.C. Sections 3701, 3702, and 3711...

  14. 32 CFR 750.13 - Claims: Single service responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Foreign Claims Act (10 U.S.C. 2734); (2) Military Claims Act (10 U.S.C. 2733); (3) International... international agreement; (4) NATO Status of Forces Agreement (4 UST 1792, TIAS 2846) and other similar... other provision of law; (7) Federal Claims Collection Act (31 U.S.C. Sections 3701, 3702, and 3711...

  15. 32 CFR 750.13 - Claims: Single service responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Foreign Claims Act (10 U.S.C. 2734); (2) Military Claims Act (10 U.S.C. 2733); (3) International... international agreement; (4) NATO Status of Forces Agreement (4 UST 1792, TIAS 2846) and other similar... other provision of law; (7) Federal Claims Collection Act (31 U.S.C. Sections 3701, 3702, and 3711...

  16. 78 FR 57170 - Endangered and Threatened Wildlife and Plants; Recovery Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ....gov (email). SUPPLEMENTARY INFORMATION: Background The Act (16 U.S.C. 1531 et seq.) prohibits... available for review, subject to the requirements of the Privacy Act (5 U.S.C. 552a) and Freedom of Information Act (5 U.S.C. 552). Permit Application Number: TE046795 Applicant: Colorado State University...

  17. 78 FR 15736 - Endangered and Threatened Wildlife and Plants; Recovery Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ....gov (email). SUPPLEMENTARY INFORMATION: Background The Act (16 U.S.C. 1531 et seq.) prohibits..., subject to the requirements of the Privacy Act (5 U.S.C. 552a) and Freedom of Information Act (5 U.S.C... (Acipenser transmontanus), bonytail chub (Gila elegans), Colorado pikeminnow (Ptychocheilus Lucius), humpback...

  18. 78 FR 59051 - Endangered and Threatened Wildlife and Plants; Recovery Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ....gov (email). SUPPLEMENTARY INFORMATION: Background The Act (16 U.S.C. 1531 et seq.) prohibits... their applications are available for review, subject to the requirements of the Privacy Act (5 U.S.C. 552a) and Freedom of Information Act (5 U.S.C. 552). Permit Application Number: TE046427 Applicant...

  19. 77 FR 7175 - Endangered and Threatened Species Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    .... SUPPLEMENTARY INFORMATION: Public Availability of Comments The Act (16 U.S.C. 1531 et seq.) prohibits activities... these applications are available for review, subject to the requirements of the Privacy Act (5 U.S.C. 552a) and Freedom of Information Act (5 U.S.C. 552). Permit TE-202343 Applicant: Daniel Ginter...

  20. 31 CFR 548.701 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (a) Attention is directed to section 206 of the International Emergency Economic Powers Act (50 U.S.C... adjustment pursuant to the Federal Civil Penalties Inflation Adjustment Act of 1990 (Pub. L. 101-410, as... pursuant to 18 U.S.C. 3571. (c) Attention is also directed to 18 U.S.C. 1001, which provides that whoever...

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