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Sample records for high gain spontaneous

  1. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOEpatents

    Hackel, Lloyd A.; Soules, Thomas F.; Fochs, Scott N.; Rotter, Mark D.; Letts, Stephan A.

    2008-12-09

    A novel method and apparatus for suppressing ASE and parasitic oscillation modes in a high average power laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges using a substantially high index bonding elastomer or epoxy to a predetermined electromagnetic absorbing arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE and parasitic oscillation modes can be effectively suppressed.

  2. Criterion of transverse coherence of self-amplified spontaneous emission in high gain free electron laser amplifiers

    SciTech Connect

    Xie, M.; Kim, K.J.

    1995-12-31

    In a high gain free electron laser amplifier based on Self-Amplified Spontaneous Emission (SASE) the spontaneous radiation generated by an electron beam near the undulator entrance is amplified many orders of magnitude along the undulator. The transverse coherence properties of the amplified radiation depends on both the amplification process and the coherence of the seed radiation (the undulator radiation generated in the first gain length or so). The evolution of the transverse coherence in the amplification process is studied based on the solution of the coupled Maxwell-Vlasov equations including higher order transverse modes. The coherence of the seed radiation is determined by the number of coherent modes in the phase space area of the undulator radiation. We discuss the criterion of transverse coherence and identify governing parameters over a broad range of parameters. In particular we re-examine the well known emittance criterion for the undulator radiation, which states that full transverse coherence is guaranteed if the rms emittance is smaller than the wavelength divided by 4{pi}. It is found that this criterion is modified for SASE because of the different optimization conditions required for the electron beam. Our analysis is a generalization of the previous study by Yu and Krinsky for the case of vanishing emittance with parallel electron beam. Understanding the transverse coherence of SASE is important for the X-ray free electron laser projects now under consideration at SLAC and DESY.

  3. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOEpatents

    Hackel, Lloyd A [Livermore, CA; Soules, Thomas F [Livermore, CA; Fochs, Scott N [Livermore, CA; Rotter, Mark D [San Ramon, CA; Letts, Stephan A [San Ramon, CA

    2011-02-22

    A novel method and apparatus for suppressing ASE and/or parasitic oscillation modes in a laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges to a predetermined electromagnetic absorbing material arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE, parasitic oscillation modes and/or residual pump energy can be effectively suppressed.

  4. FEL gain optimisation and spontaneous radiation

    SciTech Connect

    Bali, L.M.; Srivastava, A.; Pandya, T.P.

    1995-12-31

    Colson have evaluated FEL gains for small deviations from perfect electron beam injection, with radiation of the same polarisation as that of the wiggler fields. We find that for optimum gain the polarisation of the optical field should be the same as that of the spontaneous emission under these conditions. With a helical wiggler the axial oscillations resulting from small departures from perfect electron beam injection lead to injection dependent unequal amplitudes and phases of the spontaneous radiation in the two transverse directions. Viewed along the axis therefore the spontaneous emission is elliptically polarised. The azimuth of the ellipse varies with the difference of phase of the two transverse components of spontaneous emission but the eccentricity remains the same. With planar wigglers the spontaneous emission viewed in the axial direction is linearly polarised, again with an injection dependent azimuth. For optimum coherent gain of a radiation field its polarisation characteristics must be the same as those of the spontaneous radiation with both types of wiggler. Thus, with a helical wiggler and the data reported earlier, an increase of 10% in the FEL gain at the fundamental frequency and of 11% at the fifth harmonic has been calculated in the small gain per pass limit. Larger enhancements in gain may result from more favourable values of input parameters.

  5. Helicopter high gain control

    NASA Technical Reports Server (NTRS)

    Cunningham, T. B.; Nunn, E. C.

    1979-01-01

    High gain control is explored through a design study of the CH-47B helicopter. The plans are designed to obtain the maximum bandwidth possible given the hardware constraints. Controls are designed with modal control theory to specific bandwidths and closed loop mode shapes. Comparisons are made to an earlier complementary filter approach. Bandwidth improvement by removal of limitations is explored in order to establish hardware and mechanization options. Improvements in the pitch axis control system and in the rate gyro sensor noise characteristics in all axes are discussed. The use of rotor state feedback is assessed.

  6. Calculation of spontaneous emission and gain spectra for quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Yang, Q. K.; Li, A. Z.

    2000-02-01

    In this paper, a quantum cascade laser has been treated as a three-level system, and the calculation of the spontaneous emission and gain spectra has been given. In the calculation, the conduction band nonparabolicity and the injection and exit of electrons have been considered. Results have shown that with increasing injection current, the spontaneous emission peak blue shifts, and the peak intensity increases near linearly with current. With increasing temperatures, the broadening of the spontaneous emission spectra has been attributed to the electron-optical phonon interactions. The peak gain of the stimulated emission has been shown to be determined mainly by the subband lifespans. We have pointed out that it is essential to obtain a long lifespan for the second excited state and short lifespan for the first excited state in order to obtain efficient population inversion and high peak gain for quantum cascade lasers.

  7. Review of High Gain FELs

    SciTech Connect

    Shintake, Tsumoru

    2007-01-19

    For understanding on basic radiation mechanism of the high-gain FEL based on SASE, the author presents electron-crystal interpretation of FEL radiation. In the electron-crystal, electrons are localized at regularly spaced multi-layers, which represents micro-bunching, whose spacing is equal to the radiation wavelength, and the multi-layers are perpendicular to beam axis, thus, diffracted wave creates Bragg's spots in forward and backward directions. Due to the Doppler's effect, frequency of the back-scattered wave is up-converted, generates forwardly focused X-ray. The Bragg's effect contributes focusing the X-ray beam into a spot, thus peak power becomes extremely higher by factor of typically 107. This is the FEL radiation. As well known, the total numbers of scattered photons in Bragg's spots is equal to the total elastic scattering photons from the atoms contained in the crystal. Therefore, total power in the FEL laser is same as the spontaneous radiation power from the undulator for the same beam parameter. The FEL radiation phenomenon is simple interference effect. In today's presentations, we use the laser pointer, and we frequently experience difficulty in pointing precisely or steadily in one place on the screen, since the laser spot is very small and does not spread. Exactly same to this, X-ray FEL is a highly focused beam, and pointing stability dominates productivity of experiment, thus we need special care on beam stability from linear accelerator.

  8. Recent Progress in High-Gain FEL Theory

    SciTech Connect

    Huang, Z.; /SLAC

    2005-09-30

    High-gain free electron lasers (FEL) are being developed as extremely bright x-ray sources of a next-generation radiation facility. In this paper, we review the basic theory and the recent progress in understanding the startup, the exponential growth and the saturation of the high-gain process, emphasizing the self-amplified spontaneous emission (SASE). We will also discuss how the FEL performance may be affected by various errors and wakefield effects in the undulator.

  9. Theory of noise in high-gain surface plasmon-polariton amplifiers incorporating dipolar gain media.

    PubMed

    De Leon, Israel; Berini, Pierre

    2011-10-10

    A theoretical analysis of noise in high-gain surface plasmon-polariton amplifiers incorporating dipolar gain media is presented. An expression for the noise figure is obtained in terms of the spontaneous emission rate into the amplified surface plasmon-polariton taking into account the different energy decay channels experienced by dipoles in close proximity to the metallic surface. Two amplifier structures are examined: a single-interface between a metal and a gain medium and a thin metal film bounded by identical gain media on both sides. A realistic configuration is considered where the surface plasmon-polariton undergoing amplification has a Gaussian field profile in the plane of the metal and paraxial propagation along the amplifier's length. The noise figure of these plasmonic amplifiers is studied considering three prototypical gain media with different permittivities. It is shown that the noise figure exhibits a strong dependance on the real part of the permittivities of the metal and gain medium, and that its minimum value is 4/π(∼3.53 dB). The origin of this minimum value is discussed. It is also shown that amplifier configurations supporting strongly confined surface plasmon-polaritons suffer from a large noise figure, which follows from an enhanced spontaneous emission rate due to the Purcell effect.

  10. High current gain transistor laser

    PubMed Central

    Liang, Song; Qiao, Lijun; Zhu, Hongliang; Wang, Wei

    2016-01-01

    A transistor laser (TL), having the structure of a transistor with multi-quantum wells near its base region, bridges the functionality gap between lasers and transistors. However, light emission is produced at the expense of current gain for all the TLs reported up to now, leading to a very low current gain. We propose a novel design of TLs, which have an n-doped InP layer inserted in the emitter ridge. Numerical studies show that a current flow aperture for only holes can be formed in the center of the emitter ridge. As a result, the common emitter current gain can be as large as 143.3, which is over 15 times larger than that of a TL without the aperture. Besides, the effects of nonradiative recombination defects can be reduced greatly because the flow of holes is confined in the center region of the emitter ridge. PMID:27282466

  11. High temperature electronic gain device

    DOEpatents

    McCormick, J. Byron; Depp, Steven W.; Hamilton, Douglas J.; Kerwin, William J.

    1979-01-01

    An integrated thermionic device suitable for use in high temperature, high radiation environments. Cathode and control electrodes are deposited on a first substrate facing an anode on a second substrate. The substrates are sealed to a refractory wall and evacuated to form an integrated triode vacuum tube.

  12. Proton-transfer laser: gain spectrum and amplification of spontaneous emission of 3-hydroxyflavone

    SciTech Connect

    Chou, P.; McMorrow, D.; Aartsma, T.J.; Kasha, M.

    1984-09-27

    The efficient generations of amplified spontaneous emission (ASE) in 3-hydroxyflavone in methylcyclohexane and p-dioxane solutions at 293 K is reported. This application of excited-state proton-transfer tautomerization approaches an ideal four-level laser system involving four different molecular electronic species in separate electronic states and constitutes a photoinduced chemical laser. The gain coefficient for the ASE (530 nm) of 3-hydroxyflavone in methylcyclohexane (293 K) is calculated to be 10-15. Under similar conditions in our apparatus, the gain coefficient is observed to be in the range 7-9 for a proprietary coumarin laser dye (Molectron 70371-4 C485) and for rhodamine-6G. The tunable range for 3-hydroxyflavone is observed to be 518-545 nm. The peak laser power is comparable with that observed for the coumarin dye.

  13. Spontaneous Emission and Fundamental Limitations on the Signal-to-Noise Ratio in Deep-Subwavelength Plasmonic Waveguide Structures with Gain

    NASA Astrophysics Data System (ADS)

    Vyshnevyy, Andrey A.; Fedyanin, Dmitry Yu.

    2016-12-01

    Incorporation of gain media in plasmonic nanostructures can give the possibility to compensate for high Ohmic losses in the metal and design truly nanoscale optical components for diverse applications ranging from biosensing to on-chip data communication. However, the process of stimulated emission in the gain medium is inevitably accompanied by spontaneous emission. This spontaneous emission greatly impacts the performance characteristics of deep-subwavelength active plasmonic devices and casts doubt on their practical use. Here we develop a theoretical framework to evaluate the influence of spontaneous emission, which can be applied to waveguide structures of any shape and level of mode confinement. In contrast to the previously developed theories, we take into account that the spectrum of spontaneous emission can be very broad and nonuniform, which is typical for deep-subwavelength structures, where a high optical gain (approximately 1000 cm-1 ) in the active medium is required to compensate for strong absorption in the metal. We also present a detailed study of the spontaneous emission noise in metal-semiconductor active plasmonic nanowaveguides and demonstrate that by using both optical and electrical filtering techniques, it is possible to decrease the noise to a level sufficient for practical applications at telecom and midinfrared wavelengths.

  14. Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats.

    PubMed

    Oxenkrug, Gregory F; Summergrad, Paul

    2010-06-01

    The neuroendocrine theory of aging suggests the common mechanisms of developmental (prereproductive) and aging (postreproductive) processes and identified a cluster of conditions (hypertension, obesity, dyslipidemia, type 2 diabetes, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndrome (MetS). Because melatonin attenuated development of MetS is age-dependent, that is, in young and old, but not in middle-aged rats, we studied the effect of the selective melatonin agonist, Ramelteon, on the two core symptoms of MetS/AAND: hypertension and body weight gain in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto male rats (WKY). SHR rats developed hypertension at the time of maximal weight gain that coincided with the onset of reproductive activity (8-10 weeks old). Chronic (but not acute) administration of Ramelteon (in drinking water, 8 mg/kg/day, from 4 to 12 weeks of age) attenuated age-associated increase of systolic blood pressure (tail-cuff method) by 45%, and age-associated body weight gain by 30%. Acute and chronic Ramelteon did not affect blood pressure and body weight in normotensive WKY rats. Ramelteon-induced attenuation of age-associated hypertension and weight gain suggests that Ramelteon might attenuate the other symptoms of MetS/AAND and might be useful in the treatment of MetS/AAND during puberty, menopause, and old age.

  15. Hybrid optical antenna with high directivity gain.

    PubMed

    Bonakdar, Alireza; Mohseni, Hooman

    2013-08-01

    Coupling of a far-field optical mode to electronic states of a quantum absorber or emitter is a crucial process in many applications, including infrared sensors, single molecule spectroscopy, and quantum metrology. In particular, achieving high quantum efficiency for a system with a deep subwavelength quantum absorber/emitter has remained desirable. In this Letter, a hybrid optical antenna based on coupling of a photonic nanojet to a metallo-dielectric antenna is proposed, which allows such efficient coupling. A quantum efficiency of about 50% is predicted for a semiconductor with volume of ~λ³/170. Despite the weak optical absorption coefficient of 2000 cm(-1) in the long infrared wavelength of ~8 μm, very strong far-field coupling has been achieved, as evidenced by an axial directivity gain of 16 dB, which is only 3 dB below of theoretical limit. Unlike the common phased array antenna, this structure does not require coherent sources to achieve a high directivity. The quantum efficiency and directivity gain are more than an order of magnitude higher than existing metallic, dielectric, or metallo-dielectric optical antenna.

  16. High gain feedback and telerobotic tracking

    NASA Technical Reports Server (NTRS)

    Koditschek, D. E.

    1987-01-01

    Asymptotically stable linear time invariant systems are capable of tracking arbitrary reference signals with a bounded error proportional to the magnitude of the reference signal (and its derivatives). It is shown that a similar property holds for a general class of nonlinear dynamical systems which includes all robots. As in the linear case, the error bound may be made arbitrarily small by increasing the magnitude of the feedback gains which stabilize the system.

  17. High Efficiency Targets for High Gain Inertial Confinement Fusion.

    DTIC Science & Technology

    1986-09-19

    Inertial Confinement Fusion JOHN H. GARDNER AND STEPHEN E. BODNER Laboratory for Computational Physics DTIC CD ELECTEf OCT 241986 j NU Aproedfr...81425 " 11 TITLE (include Security Classification) High Efficiency Targets for High Gain Inertial Confinement Fusion 12. PERSONAL AUTHOR(S) Gardner, John ...ArearCod) 22c OFFICE SYMBOL % John H. Gardner (202) 767-3055 Code 4040 DO FORM 1473. 84 MAR 83 APR edtion may be used until exhausted SECURITY

  18. Spontaneous sidebanding in high speed rotordynamics

    NASA Astrophysics Data System (ADS)

    Ehrich, F. F.

    1992-10-01

    It is noted that the spontaneous sideband spacing frequency seems to be a whole number fraction (1/J) of the operating speed which indicates that the wave form is periodic and completes a full cycle every J rotations of the rotor. Employing a numerical model of a rotor that simulates local contact with a stator in close proximity as a bilinear spring, studies have been conducted to explore the circumstances for this spontaneous sidebanding. Two general classes of this type of response are determined in a system that is effectively single-degree-of-freedom.

  19. High-Gain High-Field Fusion Plasma

    PubMed Central

    Li, Ge

    2015-01-01

    A Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST. PMID:26507314

  20. Circular polarization with crossed-planar undulators in high gain FELs.

    SciTech Connect

    Kim, K.-J.

    1999-08-31

    We propose a crossed undulator configuration for a high-gain free-electron laser to allow versatile polarization control. This configuration consists of a long (saturation length) planar undulator, a dispersive section, and a short (a few gain lengths) planar undulator oriented perpendicular to the first one. In the first undulator, a radiation component linearly polarized in the x-direction is amplified to saturation. In the second undulator, the x-polarized component propagates freely, while a new component, polarized in the y-direction, is generated and reaches saturation in a few gain lengths. By adjusting the strength of the dispersive section, the relative phase of two radiation components can be adjusted to obtain a suitable polarization for the total radiation field, including the circular polarization. The operating principle of the high-gain crossed undulator, which is quite different from that of the crossed undulator for spontaneous radiation, is illustrated in terms of 1-D FEL theory.

  1. High gain durable anti-reflective coating

    DOEpatents

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze'ev R.

    2016-07-26

    Disclosed herein are polysilsesquioxane-based anti-reflective coating (ARC) compositions, methods of preparation, and methods of deposition on a substrate. In one embodiment, the polysilsesquioxane of this disclosure is prepared in a two-step process of acid catalyzed hydrolysis of organoalkoxysilane followed by addition of tetralkoxysilane that generates silicone polymers with >40 mol % silanol based on Si-NMR. These high silanol siloxane polymers are stable and have a long shelf-life in polar organic solvents at room temperature. Also disclosed are low refractive index ARC made from these compositions with and without additives such as porogens, templates, thermal radical initiator, photo radical initiators, crosslinkers, Si--OH condensation catalyst and nano-fillers. Also disclosed are methods and apparatus for applying coatings to flat substrates including substrate pre-treatment processes, coating processes and coating curing processes including skin-curing using hot-air knives. Also disclosed are coating compositions and formulations for highly tunable, durable, highly abrasion-resistant functionalized anti-reflective coatings.

  2. Cold test, spontaneous emission and gain in a rectangular Cerenkov amplifier

    SciTech Connect

    Scharer, J.E.; Joe, J.; Booske, J.H.; Basten, M.; Kirolous, H.

    1994-12-31

    The authors present experimental results for the rectangular Cerenkov grating amplifier. This research is being carried out to develop a Ka-band (35 GHz), low voltage (10 kV), moderate power (10 kW) source. They have constructed a Ku-band grating structure to study a scaled version of this source. The tapered grating consists of two tapered Ku-band smooth wave guide sections and two 3.5-inch sections of five-step-tapered gratings. Both tapered and untapered grating structures have been cold tested utilizing the network analyzer measurements. They find that their taper design reduced the reflection coefficient from {minus}5 dB to less than {minus}20 dB over a 12--15 GHz bandwidth. Spontaneous emission results resulting from passing the circular electron beam from a Litton thermionic gun over the grating structure will be presented. They have theoretically investigated the sheet beam interaction with hybrid modes in a deep groove rectangular grating waveguide. A complex dispersion relation, which includes a finite axial energy spread of the beam, describing the interaction has been solved. The authors find that the instability is always convective in the forward wave mode regime.

  3. Computer simulation of space station computer steered high gain antenna

    NASA Technical Reports Server (NTRS)

    Beach, S. W.

    1973-01-01

    The mathematical modeling and programming of a complete simulation program for a space station computer-steered high gain antenna are described. The program provides for reading input data cards, numerically integrating up to 50 first order differential equations, and monitoring up to 48 variables on printed output and on plots. The program system consists of a high gain antenna, an antenna gimbal control system, an on board computer, and the environment in which all are to operate.

  4. High gain amplifiers: Power oscillations and harmonic generation

    SciTech Connect

    Dattoli, G.; Ottaviani, P. L.; Pagnutti, S.

    2007-08-01

    We discuss the power oscillations in saturated high gain free electron laser amplifiers and show that the relevant period can be written in terms of the gain length. We use simple arguments following from the solution of the pendulum equation in terms of Jacobi elliptic functions. Nontrivial effects due to nonlinear harmonic generation and inhomogeneous broadening are discussed too, as well as the saturated dynamics of short pulses.

  5. Coherent spontaneous radiation from highly bunched electron beams

    SciTech Connect

    Berryman, K.W.; Crosson, E.R.; Ricci, K.N.

    1995-12-31

    Coherent spontaneous radiation has now been observed in several FELs, and is a subject of great importance to the design of self-amplified spontaneous emission (SASE) devices. We report observations of coherent spontaneous radiation in both FIREFLY and the mid-infrared FEL at the Stanford Picosecond FEL Center. Coherent emission has been observed at wavelengths as short as 5 microns, and enhancement over incoherent levels by as much as a factor of 4x10{sup 4} has been observed at longer wavelengths. The latter behavior was observed at 45 microns in FIREFLY with short bunches produced by off-peak acceleration and dispersive compression. We present temporal measurements of the highly bunched electron distributions responsible for the large enhancements, using both transition radiation and energy-phase techniques.

  6. High Reported Spontaneous Stuttering Recovery Rates: Fact or Fiction?

    ERIC Educational Resources Information Center

    Ramig, Peter R.

    1993-01-01

    Contact after 6 to 8 years with families of 21 children who were diagnosed as stuttering but did not receive fluency intervention services found that almost all subjects still had a stuttering problem. Results dispute the high spontaneous recovery rates reported in the literature and support the value of early intervention. (Author/DB)

  7. ZnO nanowire UV photodetectors with high internal gain.

    PubMed

    Soci, C; Zhang, A; Xiang, B; Dayeh, S A; Aplin, D P R; Park, J; Bao, X Y; Lo, Y H; Wang, D

    2007-04-01

    ZnO nanowire (NW) visible-blind UV photodetectors with internal photoconductive gain as high as G approximately 108 have been fabricated and characterized. The photoconduction mechanism in these devices has been elucidated by means of time-resolved measurements spanning a wide temporal domain, from 10-9 to 102 s, revealing the coexistence of fast (tau approximately 20 ns) and slow (tau approximately 10 s) components of the carrier relaxation dynamics. The extremely high photoconductive gain is attributed to the presence of oxygen-related hole-trap states at the NW surface, which prevents charge-carrier recombination and prolongs the photocarrier lifetime, as evidenced by the sensitivity of the photocurrrent to ambient conditions. Surprisingly, this mechanism appears to be effective even at the shortest time scale investigated of t < 1 ns. Despite the slow relaxation time, the extremely high internal gain of ZnO NW photodetectors results in gain-bandwidth products (GB) higher than approximately 10 GHz. The high gain and low power consumption of NW photodetectors promise a new generation of phototransistors for applications such as sensing, imaging, and intrachip optical interconnects.

  8. Characteristics of current filamentation in high gain photoconductive semiconductor switching

    SciTech Connect

    Zutavern, F J; Loubriel, G M; O'Malley, M W; Helgeson, W D; McLaughlin, D L; Denison, G J

    1992-01-01

    Characteristics of current filamentation are reported for high gain photoconductive semiconductor switches (PCSS). Infrared photoluminescence is used to monitor carrier recombination radiation during fast initiation of high gain switching in large (1.5 cm gap) lateral GaAs PCSS. Spatial modulation of the optical trigger, a 200--300 ps pulse width laser, is examined. Effects on the location and number of current filaments, rise time, and delay to high gain switching, minimum trigger energy, and degradation of switch contacts are presented. Implications of these measurements for the theoretical understanding and practical development of these switches are discussed. Efforts to increase current density and reduce switch size and optical trigger energy requirements are described. Results from contact development and device lifetime testing are presented and the impact of these results on practical device applications is discussed.

  9. Caustic Singularities Of High-Gain, Dual-Shaped Reflectors

    NASA Technical Reports Server (NTRS)

    Galindo, Victor; Veruttipong, Thavath W.; Imbriale, William A.; Rengarajan, Sambiam

    1991-01-01

    Report presents study of some sources of error in analysis, by geometric theory of diffraction (GTD), of performance of high-gain, dual-shaped antenna reflector. Study probes into underlying analytic causes of singularity, with view toward devising and testing practical methods to avoid problems caused by singularity. Hybrid physical optics (PO) approach used to study near-field spillover or noise-temperature characteristics of high-gain relector antenna efficiently and accurately. Report illustrates this approach and underlying principles by presenting numerical results, for both offset and symmetrical reflector systems, computed by GTD, PO, and PO/GO methods.

  10. On Point Designs for High Gain Fast Ignition

    SciTech Connect

    Key, M; Akli, K; Beg, F; Betti, R; Clark, D S; Chen, S N; Freeman, R R; Hansen, S; Hatchett, S P; Hey, D; King, J A; Kemp, A J; Lasinski, B F; Langdon, B; Ma, T; MacKinnon, A J; Meyerhofer, D; Patel, P K; Pasley, J; Phillips, T; Stephens, R B; Stoeckl, C; Foord, M; Tabak, M; Theobald, W; Storm, M; Town, R J; Wilks, S C; VanWoerkom, L; Wei, M S; Weber, R; Zhang, B

    2007-09-27

    Fast ignition research has reached the stage where point designs are becoming crucial to the identification of key issues and the development of projects to demonstrate high gain fast ignition. The status of point designs for cone coupled electron fast ignition and some of the issues they highlight are discussed.

  11. Radiation Response of Emerging High Gain, Low Noise Detectors

    NASA Technical Reports Server (NTRS)

    Becker, Heidi N.; Farr, William H; Zhu, David Q.

    2007-01-01

    Data illustrating the radiation response of emerging high gain, low noise detectors are presented. Ionizing dose testing of silicon internal discrete avalanche photodiodes, and 51-MeV proton testing of InGaAs/InAlAs avalanche photodiodes operated in Geiger mode are discussed.

  12. Silicon photodiodes with high photoconductive gain at room temperature.

    PubMed

    Li, X; Carey, J E; Sickler, J W; Pralle, M U; Palsule, C; Vineis, C J

    2012-02-27

    Silicon photodiodes with high photoconductive gain are demonstrated. The photodiodes are fabricated in a complementary metal-oxide-semiconductor (CMOS)-compatible process. The typical room temperature responsivity at 940 nm is >20 A/W and the dark current density is ≈ 100 nA/cm2 at 5 V reverse bias, yielding a detectivity of ≈ 10(14) Jones. These photodiodes are good candidates for applications that require high detection sensitivity and low bias operation.

  13. UV x-ray free electron lasers through high-gain single pass amplifier: Basic principles and issues

    SciTech Connect

    Kim, K.J.

    1994-09-01

    The author reviews the basic principles of high gain free electron laser amplifier in single pass configuration for generation of intense, tunable radiation for wavelength shorter than 1,000 {angstrom}. Two schemes are discussed: for wavelength region between 1,000--100 {angstrom}, the high gain harmonic generation of a coherent input radiation can be used. For x-ray wavelength as short as a few {angstrom}, the self-amplified spontaneous emission is currently the only known free electron laser scheme. The author also presents a brief introduction of various key issues in realizing these schemes, which will be discussed in detail in other papers in these proceedings.

  14. High-Frequency Power Gain in the Mammalian Cochlea

    NASA Astrophysics Data System (ADS)

    Maoiléidigh, Dáibhid Ó.; Hudspeth, A. J.

    2011-11-01

    Amplification in the mammalian inner ear is thought to result from a nonlinear active process known as the cochlear amplifier. Although there is much evidence that outer hair cells (OHCs) play a central role in the cochlear amplifier, the mechanism of amplification remains uncertain. In non-mammalian ears hair bundles can perform mechanical work and account for the active process in vitro, yet in the mammalian cochlea membrane-based electromotility is required for amplification in vivo. A key issue is how OHCs conduct mechanical power amplification at high frequencies. We present a physical model of a segment of the mammalian cochlea that can amplify the power of external signals. In this representation both electromotility and active hair-bundle motility are required for mechanical power gain at high frequencies. We demonstrate how the endocochlear potential, the OHC resting potential, Ca2+ gradients, and ATP-fueled myosin motors serve as the energy sources underlying mechanical power gain in the cochlear amplifier.

  15. Cathode driven high gain crossed-field amplifier

    NASA Astrophysics Data System (ADS)

    1983-07-01

    The objective of this three-phase program is to achieve the design of a cathode driven high gain re-entrant Crossed Field Amplifier capable of meeting the parameters of Raytheon Company specification No. 968838 dated 10 May 1978. The effort includes the fabrication and test of three developmental and four final configuration tubes. One final configuration tube will be life tested and two will be delivered to the Navy. The tasks discussed during this report period relate to the cold tests performed on various subassemblies of model no. 4 and on the sealed-in model no. 4 of the S-band high gain cathode driven crossed field amplifier. Based on the performance of model no. 3 certain remedial measures have been implemented in model no. 4 that have resulted in the elimination of key resonances within the tube and an improvement in the isolation between the cathode and anode circuits.

  16. Transverse amplified spontaneous emission: The limiting factor for output energy of ultra-high power lasers

    NASA Astrophysics Data System (ADS)

    Chvykov, Vladimir; Nees, John; Krushelnick, Karl

    2014-02-01

    For the new generation of the ultra-high power lasers with tens of PW of output power, kJ-level energies have to be reached. Our modeling, applied to Ti:sapphire amplifiers, demonstrates for the first time, according our knowledge, that Transverse Amplified Spontaneous Emission (TASE) places an additional restriction on storing and extracting energy in larger gain apertures, even stronger than transverse parasitic generation (TPG). Nevertheless, we demonstrate that extracting during pumping (EDP) can significantly reduce parasitic losses due to both TASE and TPG.

  17. Remote Robot Control With High Force-Feedback Gain

    NASA Technical Reports Server (NTRS)

    Kim, Won S.

    1993-01-01

    Improved scheme for force-reflecting hand control of remote robotic manipulator provides unprecedently high force-reflection gain, even when dissimilar master and slave arms used. Three feedback loops contained in remote robot control system exerting position-error-based force feedback and compliance control. Outputs of force and torque sensors on robot not used directly for force reflection, but for compliance control, while errors in position used to generate reflected forces.

  18. Design issues for a laboratory high gain fusion facility

    SciTech Connect

    Hogan, W.J.

    1987-11-02

    In an inertial fusion laboratory high gain facility, experiments will be carried out with up to 1000 MJ of thermonuclear yield. The experiment area of such a facility will include many systems and structures that will have to operate successfully in the difficult environment created by the sudden large energy release. This paper estimates many of the nuclear effects that will occur, discusses the implied design issues and suggests possible solutions so that a useful experimental facility can be built. 4 figs.

  19. High gain preamplifier based on optical parametric amplification

    DOEpatents

    Jovanovic, Igor; Bonner, Randal A.

    2004-08-10

    A high-gain preamplifier based on optical parametric amplification. A first nonlinear crystal is operatively connected to a second nonlinear crystal. A first beam relay telescope is operatively connected to a second beam relay telescope, to the first nonlinear crystal, and to the second nonlinear crystal. A first harmonic beamsplitter is operatively connected to a second harmonic beamsplitter, to the first nonlinear crystal, to the second nonlinear crystal, to the first beam relay telescope, and to the second beam relay telescope.

  20. High-gain phototransistors on high-resistivity silicon substrate

    NASA Astrophysics Data System (ADS)

    Batignani, G.; Bisogni, M. G.; Boscardin, M.; Bosisio, L.; Dalla Betta, G. F.; Del Guerra, A.; Dittongo, S.; Forti, F.; Giorgi, M.; Han, D. J.; Linsalata, S.; Marchiori, G.; Piemonte, C.; Rachevskaia, I.; Ronchin, S.

    2004-02-01

    NPN phototransistors have been fabricated on high-purity silicon substrate. The devices have been produced by ITC-IRST in the framework of a National Research Project funded by the Italian Education, University and Research Ministry (MIUR). The phototransistor emitter is composed of a phosphorus n + implant, the base is a diffused high-energy boron implant, and the collector is the 300 μm thick silicon bulk. Several devices have been investigated. Results with 22 keV X-ray from a 109Cd-radioactive source and visible light irradiation are presented.

  1. STARS A Two Stage High Gain Harmonic Generation FEL Demonstrator

    SciTech Connect

    M. Abo-Bakr; W. Anders; J. Bahrdt; P. Budz; K.B. Buerkmann-Gehrlein; O. Dressler; H.A. Duerr; V. Duerr; W. Eberhardt; S. Eisebitt; J. Feikes; R. Follath; A. Gaupp; R. Goergen; K. Goldammer; S.C. Hessler; K. Holldack; E. Jaeschke; Thorsten Kamps; S. Klauke; J. Knobloch; O. Kugeler; B.C. Kuske; P. Kuske; A. Meseck; R. Mitzner; R. Mueller; M. Neeb; A. Neumann; K. Ott; D. Pfluckhahn; T. Quast; M. Scheer; Th. Schroeter; M. Schuster; F. Senf; G. Wuestefeld; D. Kramer; Frank Marhauser

    2007-08-01

    BESSY is proposing a demonstration facility, called STARS, for a two-stage high-gain harmonic generation free electron laser (HGHG FEL). STARS is planned for lasing in the wavelength range 40 to 70 nm, requiring a beam energy of 325 MeV. The facility consists of a normal conducting gun, three superconducting TESLA-type acceleration modules modified for CW operation, a single stage bunch compressor and finally a two-stage HGHG cascaded FEL. This paper describes the faciliy layout and the rationale behind the operation parameters.

  2. A high gain antenna system for airborne satellite communication applications

    NASA Technical Reports Server (NTRS)

    Maritan, M.; Borgford, M.

    1990-01-01

    A high gain antenna for commercial aviation satellites communication is discussed. Electromagnetic and practical design considerations as well as candidate systems implementation are presented. An evaluation of these implementation schemes is given, resulting in the selection of a simple top mounted aerodynamic phased array antenna with a remotely located beam steering unit. This concept has been developed into a popular product known as the Canadian Marconi Company CMA-2100. A description of the technical details is followed by a summary of results from the first production antennas.

  3. Effect of oxygen at high pressure on spontaneous transmitter release.

    PubMed

    Colton, J S; Colton, C A

    1978-11-01

    The effect of oxygen at high pressure (OHP) on resting membrane properties (effective membrane resistance (Reff) and membrane potential (Vm)) and the spontaneous release of excitatory transmitter were examined at the lobster neuromuscular junction. Pressurization with 100% oxygen to 150 pounds per square inch gauge pressure (psig) or with nitrogen to 150 psig (7,000 mmHg nitrogen and 135 mmHg oxygen) produced a decrease in Reff associated with a hyperpolarization of Vm. These changes, however, returned to control values within 20--30 min after completion of pressurization. Spontaneous release of excitatory transmitter was shown to increase dramatically in the presence of 100% oxygen at 150 psig. The increase in miniature end-plate potential (MEPP) frequency persisted beyond the transient changes seen with Reff and Vm. This effect was selective to oxygen, as pressurization with nitrogen did not produce an increase in MEPP frequency. No change in average MEPP amplitude was seen with either OHP or pressure alone. An OHP-induced increase in MEPP frequency was also seen at the frog neuromuscular junction. The results indicate that both glutamate-mediated and acetylcholine-mediated synaptic transmission are altered by OHP.

  4. Critical review of high gain x-ray FEL experiments

    SciTech Connect

    Kim, Kwang-Je

    1996-08-01

    There is a renewed interest at the present time to develop x-ray free electron lasers (FELs). The interest is driven by the scientific opportunities with coherent x-rays glimpsed at the third generation light sources. With the recent development in linac technology in producing high-energy, high-brightness electron beams, it is now possible to design intense coherent x-ray source for wavelengths as short as one Angstrom based on the self- amplified spontaneous emission (SASE) principle. Major linac laboratories such as SLAC and DESY are therefore actively pursuing detailed design studies for the x-ray SASE facilities. The x-rays from these facilities will provide a peak brightness more than ten orders of magnitude higher than that of the current synchrotron radiation sources. Short wavelength coherent radiation could also be generated with harmonic generation techniques in linacs or storage rings. However, these schemes are not expected to be effective for 1 {Angstrom} wavelengths. This review will therefore concentrate on the linac based SASE scheme. The critical components of the SASE are: an electron source consisting of an RF photocathode gun with the emittance corrector producing high brightness electron beam; the beam bunching and acceleration; and a long undulator in which the radiation develops from initially incoherent radiation to intense, coherent radiation. We discuss the critical experimental issues in these components highlighting some relevant recent experiments. We also discuss issues related to the SASE experiment which are distinct from the usual free electron lasers. We give a brief survey of the world-wide SASE experiments. We conclude with a summary and outlook.

  5. Spontaneous Radiation Emission from Short, High Field Strength Insertion Devices

    SciTech Connect

    Geoffrey Krafft

    2005-09-15

    Since the earliest papers on undulaters were published, it has been known how to calculate the spontaneous emission spectrum from ''short'' undulaters when the magnetic field strength parameter is small compared to unity, or in ''single'' frequency sinusoidal undulaters where the magnetic field strength parameter is comparable to or larger than unity, but where the magnetic field amplitude is constant throughout the undulater. Fewer general results have been obtained in the case where the insertion device is both short, i.e., the magnetic field strength parameter changes appreciably throughout the insertion device, and the magnetic field strength is high enough that ponderomotive effects, radiation retardation, and harmonic generation are important physical phenomena. In this paper a general method is presented for calculating the radiation spectrum for short, high-field insertion devices. It is used to calculate the emission from some insertion device designs of recent interest.

  6. Spontaneous Raman scattering as a high resolution XUV radiation source

    NASA Technical Reports Server (NTRS)

    Rothenberg, J. E.; Young, J. F.; Harris, S. E.

    1983-01-01

    A type of high resolution XUV radiation source is described which is based upon spontaneous anti-Stokes scattering of tunable incident laser radiation from atoms excited to metastable levels. The theory of the source is summarized and two sets of experiments using He (1s2s)(1)S atoms, produced in a cw hollow cathode and in a pulsed high power microwave discharge, are discussed. The radiation source is used to examine transitions originating from the 3p(6) shell of potassium. The observed features include four previously unreported absorption lines and several sharp interferences of closely spaced autoionizing lines. A source linewidth of about 1.9 cm(-1) at 185,000 cm(-1) is demonstrated.

  7. High gain GaAs photoconductive semiconductor switches: Switch longevity

    SciTech Connect

    Loubriel, G.M.; Zutavern, F.J.; Mar, A.

    1998-07-01

    Optically activated, high gain GaAs switches are being tested for many different pulsed power applications that require long lifetime (longevity). The switches have p and n contact metallization (with intentional or unintentional dopants) configured in such a way as to produce p-i-n or n-i-n switches. The longevity of the switches is determined by circuit parameters and by the ability of the contacts to resist erosion. This paper will describe how the switches performed in test-beds designed to measure switch longevity. The best longevity was achieved with switches made with diffused contacts, achieving over 50 million pulses at 10 A and over 2 million pulses at 80 A.

  8. Spontaneous Raman Scattering Diagnostics for High-pressure Gaseous Flames

    NASA Technical Reports Server (NTRS)

    Kojima, Jun; Nguyen, Quang-Viet; Reddy, D. R. (Technical Monitor)

    2002-01-01

    A high-pressure (up to 60 atm) gaseous burner facility with optical access that provides steady, reproducible flames with high precision, and the ability to use multiple fuel/oxidizer combinations has been developed. In addition, a high-performance spontaneous Raman scattering system for use in the above facility has also been developed. Together, the two systems will be used to acquire and establish a comprehensive Raman scattering spectral database for use as a quantitative high-pressure calibration of single-shot Raman scattering measurements in high-pressure combustion systems. Using these facilities, the Raman spectra of H2-Air flames were successfully measured at pressures up to 20 atm. The spectra demonstrated clear rotational and ro-vibrational Raman features of H2, N2, and H2O. theoretical Raman spectra of pure rotational H2, vibrational H2, and vibrational N2 were calculated using a classical harmonic-oscillator model with pressure broadening effects and fitted to the data. At a gas temperature of 1889 K for a phi = 1.34 H2-Air flame, the model and the data showed good agreement, confirming a ro-vibrational equilibrium temperature.

  9. High-Gain Avalanche Rushing amorphous Photoconductor (HARP) detector

    NASA Astrophysics Data System (ADS)

    Tanioka, K.

    2009-09-01

    We have been studying a very sensitive image sensor since the early 1980s. In 1985, the author found for the first time that an experimental pickup tube with an amorphous selenium photoconductive target exhibits high sensitivity with excellent picture quality because of a continuous and stable avalanche multiplication phenomenon. We named the pickup tube with an amorphous photoconductive layer operating in the avalanche-mode "HARP": High-gain Avalanche Rushing amorphous Photoconductor. A color camera equipped with the HARP pickup tubes has a maximum sensitivity of 11 lx at F8. This means that the HARP camera is about 100 times as sensitive as that of CCD camera for broadcasting. This ultrahigh-sensitivity HARP pickup tube is a powerful tool for reporting breaking news at night and other low-light conditions, the production of scientific programs, and numerous other applications, including medical diagnoses, biotech research, and nighttime surveillance. In addition, since the HARP target can convert X-rays into electrons directly, it should be possible to exploit this capability to produce X-ray imaging devices with unparalleled levels of resolution and sensitivity.

  10. High-gain nonlinear observer for simple genetic regulation process

    NASA Astrophysics Data System (ADS)

    Torres, L. A.; Ibarra-Junquera, V.; Escalante-Minakata, P.; Rosu, H. C.

    2007-07-01

    High-gain nonlinear observers occur in the nonlinear automatic control theory and are in standard usage in chemical engineering processes. We apply such a type of analysis in the context of a very simple one-gene regulation circuit. In general, an observer combines an analytical differential-equation-based model with partial measurement of the system in order to estimate the non-measured state variables. We use one of the simplest observers, that of Gauthier et al., which is a copy of the original system plus a correction term which is easy to calculate. For the illustration of this procedure, we employ a biological model, recently adapted from Goodwin's old book by De Jong, in which one plays with the dynamics of the concentrations of the messenger RNA coding for a given protein, the protein itself, and a single metabolite. Using the observer instead of the metabolite, it is possible to rebuild the non-measured concentrations of the mRNA and the protein.

  11. High gain pre-amplifier laser beam quality evaluating system

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Yu, Jin; Zhao, Tianzhuo; Zhang, Xue; Fan, Zhongwei

    2011-06-01

    Designed a system for the high gain laser pre-amplifier to evaluate the image quality. The system uses 4f imaging principle and Kepler type telescope was choiced, it has two advantages: avert optical distortion and eliminate aberration in the measurement system. Combined with the location of the lens inside of pre-amplifier such as the spatial filter , the near field imaging structure was designed. The structure can be reduced to 11.9 times the beam image, and clearly passed the image to the CCD target surface. The location of first positive lens focus is the location of far field image. In this article, one laser pre-amplifier was measured. The average measured near field modulation M=1.34, the average measured far field diffraction limit is 2.94. Experiments show that the stability of measuring system is less than+/-5%, it can meet the measurement requirements of ICF laser pre-amplifier parameters. Use this system we can discover the problem during the design and installation. There is great meaning for develop of laser pre-amplifier in ICF for further.

  12. Fast ignition integrated experiments and high-gain point design

    SciTech Connect

    Shiraga, H.; Nagatomo, H.; Theobald, W.; Solodov, A. A.; Tabak, M.

    2014-04-17

    Here, integrated fast ignition experiments were performed at ILE, Osaka, and LLE, Rochester, in which a nanosecond driver laser implodes a deuterated plastic shell in front of the tip of a hollow metal cone and an intense ultrashort-pulse laser is injected through the cone to heat the compressed plasma. Based on the initial successful results of fast electron heating of cone-in-shell targets, large-energy short-pulse laser beam lines were constructed and became operational: OMEGA-EP at Rochester and LFEX at Osaka. Neutron enhancement due to heating with a ~kJ short-pulse laser has been demonstrated in the integrated experiments at Osaka and Rochester. The neutron yields are being analyzed by comparing the experimental results with simulations. Details of the fast electron beam transport and the electron energy deposition in the imploded fuel plasma are complicated and further studies are imperative. The hydrodynamics of the implosion was studied including the interaction of the imploded core plasma with the cone tip. Theory and simulation studies are presented on the hydrodynamics of a high-gain target for a fast ignition point design.

  13. Design of a high linearity and high gain accuracy analog baseband circuit for DAB receiver

    NASA Astrophysics Data System (ADS)

    Li, Ma; Zhigong, Wang; Jian, Xu; Yiqiang, Wu; Junliang, Wang; Mi, Tian; Jianping, Chen

    2015-02-01

    An analog baseband circuit of high linearity and high gain accuracy for a digital audio broadcasting receiver is implemented in a 0.18-μm RFCMOS process. The circuit comprises a 3rd-order active-RC complex filter (CF) and a programmable gain amplifier (PGA). An automatic tuning circuit is also designed to tune the CF's pass band. Instead of the class-A fully differential operational amplifier (FDOPA) adopted in the conventional CF and PGA design, a class-AB FDOPA is specially employed in this circuit to achieve a higher linearity and gain accuracy for its large current swing capability with lower static current consumption. In the PGA circuit, a novel DC offset cancellation technique based on the MOS resistor is introduced to reduce the settling time significantly. A reformative switching network is proposed, which can eliminate the switch resistor's influence on the gain accuracy of the PGA. The measurement result shows the gain range of the circuit is 10-50 dB with a 1-dB step size, and the gain accuracy is less than ±0.3 dB. The OIP3 is 23.3 dBm at the gain of 10 dB. Simulation results show that the settling time is reduced from 100 to 1 ms. The image band rejection is about 40 dB. It only draws 4.5 mA current from a 1.8 V supply voltage.

  14. Development of a 3D FEL code for the simulation of a high-gain harmonic generation experiment.

    SciTech Connect

    Biedron, S. G.

    1999-02-26

    Over the last few years, there has been a growing interest in self-amplified spontaneous emission (SASE) free-electron lasers (FELs) as a means for achieving a fourth-generation light source. In order to correctly and easily simulate the many configurations that have been suggested, such as multi-segmented wigglers and the method of high-gain harmonic generation, we have developed a robust three-dimensional code. The specifics of the code, the comparison to the linear theory as well as future plans will be presented.

  15. High gain multigap avalanche detectors for Cerenkov ring imaging

    SciTech Connect

    Gilmore, R.S.; Lavender, W.M.; Leith, D.W.G.S.; Williams, S.H.

    1980-10-01

    We report on a continuing study of multigap parallel plate avalanche chambers, primarily as photoelectron detectors for use with Cerenkov ring imaging counters. By suitable control of the fields in successive gaps and by introducing screens to reduce photon feedback to the cathode the gain many be increased considerably. We have obtained gains in excess of 6 x 10/sup 7/ for photoelectrons with a good pulse height spectrum and expect to increase this further. We discuss the use of resistive anodes to give avalanche positions in two dimensions by charge division.

  16. A large area, high gain Micro Gap Chamber

    NASA Astrophysics Data System (ADS)

    Angelini, F.; Bellazzini, R.; Bozzo, M.; Brez, A.; Massai, M. M.; Raffo, R.; Spandre, G.; Spezziga, M.; Toropin, A.

    1995-02-01

    A new approach to the construction of the Micro Gap Chamber is presented. A 10 × 10 cm 2 MGC has been built using a 8 μm thick polyimide layer as anode-cathode insulator. Studies on gas gain, uniformity of response along the strip and charging-up have been carried out in laboratory by using X-ray sources. Very large proportional gains, up to ˜ 210 4, have been reached working with gas mixtures based on Ne-DME. The simplified technology for the detector fabrication opens the possibility to produce very large area MGCs.

  17. Fluorene- and benzofluorene-cored oligomers as low threshold and high gain amplifying media

    SciTech Connect

    Kazlauskas, Karolis Kreiza, Gediminas; Bobrovas, Olegas; Adomėnienė, Ona; Adomėnas, Povilas; Juršėnas, Saulius; Jankauskas, Vygintas

    2015-07-27

    Deliberate control of intermolecular interactions in fluorene- and benzofluorene-cored oligomers was attempted via introduction of different-length alkyl moieties to attain high emission amplification and low amplified spontaneous emission (ASE) threshold at high oligomer concentrations. Containing fluorenyl peripheral groups decorated with different-length alkyl moieties, the oligomers were found to express weak concentration quenching of emission, yet excellent carrier drift mobilities (close to 10{sup −2} cm{sup 2}/V/s) in the amorphous films. Owing to the larger radiative decay rates (>1.0 × 10{sup 9 }s{sup −1}) and smaller concentration quenching, fluorene-cored oligomers exhibited down to one order of magnitude lower ASE thresholds at higher concentrations as compared to those of benzofluorene counterparts. The lowest threshold (300 W/cm{sup 2}) obtained for the fluorene-cored oligomers at the concentration of 50 wt % in polymer matrix is among the lowest reported for solution-processed amorphous films in ambient conditions, what makes the oligomers promising for lasing application. Great potential in emission amplification was confirmed by high maximum net gain (77 cm{sup −1}) revealed for these compounds. Although the photostability of the oligomers was affected by photo-oxidation, it was found to be comparable to that of various organic lasing materials including some commercial laser dyes evaluated under similar excitation conditions.

  18. High-Stakes Testing Hasn't Brought Education Gains

    ERIC Educational Resources Information Center

    Dianis, Judith Browne; Jackson, John H.; Noguera, Pedro

    2015-01-01

    The only thing that more testing will tell us is what we already know: The schools that disadvantaged children attend are not being given the supports necessary to produce achievement gains. Students cannot be tested out of poverty, and while NCLB did take us a step forward by requiring schools to produce evidence that students were learning, it…

  19. Mechanisms underlying obesity resistance associated with high spontaneous physical activity

    PubMed Central

    Teske, Jennifer A.; Billington, Charles J.; Kotz, Catherine M.

    2013-01-01

    Obesity resistance due to elevated orexin signaling is accompanied by high levels of spontaneous physical activity (SPA). The behavioral and neural mechanisms underlying this observation have not been fully worked out. We determined the contribution of hypothalamic orexin receptors (OXR) to SPA stimulated by orexin A (OXA), whether OXA-stimulated SPA was secondary to arousal and whether voluntary wheel running led to compensations in 24-h SPA. We further tested whether orexin action on dopamine one receptors (DA1R) in the substantia nigra (SN) plays an important role in generation of SPA. To test this, SPA response was determined in lean and obese rats with cannulae targeted towards the rostral lateral hypothalamus (rLH) or SN. Sleep/wake states were also measured in rats with rLH cannula and EEG/EMG radiotelemetry transmitters. SPA in lean rats was more sensitive to antagonism of the orexin 1 receptor (OX1R) and in the early response to the orexin 2 agonist. OXA increased arousal equally in lean and obese rodents, which is discordant from the greater SPA response in lean rats. Obesity resistant rats ran more and wheel running was directly related to 24-h SPA levels. The OX1R antagonist, SB-334867-A, and the DA1R antagonist, SCH3390, in SN more effectively reduced SPA stimulated by OXA in OR rats. These data suggest OXA-stimulated SPA is not secondary to enhanced arousal, propensity for SPA parallels inclination to run and that orexin action on dopaminergic neurons in SN may participate in mediation of SPA and running wheel activity. PMID:24161277

  20. Stability in high gain plasmas in DIII-D

    SciTech Connect

    Lazarus, E.A.; Houlberg, W.A.; Murakami, M.; Wade, M.R.

    1996-10-01

    Fusion power gain has been increased by a factor of 3 in DIII-D plasmas through the use of strong discharge shaping and tailoring of the pressure and current density profiles. H-mode plasmas with weak or negative central magnetic shear are found to have neoclassical ion confinement throughout most of the plasma volume. Improved MHD stability is achieved by controlling the plasma pressure profile width. The highest fusion power gain Q (ratio of fusion power to input power) in deuterium plasmas was 0.0015, which extrapolates to an equivalent Q of 0.32 in a deuterium-tritium plasma and is similar to values achieved in tokamaks of larger size and magnetic fields.

  1. Stability in High Gain Plasmas in DIII-D

    SciTech Connect

    Lazarus, E. A.; Hong, R. M.; Navratil, G. A.; Sabbagh, S.; Strait, E. J.; Rice, B. W.; Ferron, J. R.; Greenfield, C. M.; Austin, M. E.; Chan, V. S.; DeBoo, J. C.; Doyle, E. J.; Forest, C. B.; Leonard, A. W.; Schissel, D. P.; Whyte, D. G.

    1997-01-01

    Fusion power gain has been increased by a factor of 3 in DIII-D plasmas through the use of strong discharge shaping and tailoring of the pressure and current density profiles. H-mode plasmas with weak or negative central magnetic shear are found to have neoclassical ion confinement throughout most of the plasma volume. Improved MHD stability is achieved by controlling the plasma pressure profile width. The highest fusion power gain Q (ratio of fusion power to input power) in deuterium plasmas was 0.0015. which extrapolates to an equivalent Q of 0.32 in a deuterium-tritium plasma and is similar to values achieved in tokamaks of larger size and magnetic fields.

  2. Development of a 233 GHz High Gain Traveling Wave Amplifier

    DTIC Science & Technology

    2014-04-22

    USA 2Beam Wave Research, Inc., Bethesda, MD 20814 USA Abstract: We present development plans for a 233 GHz, serpentine waveguide vacuum electron...NRL G-band serpentine waveguide amplifier [2, 3] was the first demonstrated amplifier to use a UV-LIGA fabricated circuit. The small- signal gain...using the same techniques for 231.5 GHz to 235 GHz, an FCC Radiolocation band. Amplifier Design The compound, hybrid serpentine waveguide (SWG

  3. A high gain microstrip array adopting EMC dipoles

    NASA Astrophysics Data System (ADS)

    Russo, P.; Ruggieri, M.

    1988-10-01

    The design and operation of microstrip antenna arrays based on commercial feed boards and electromagnetically coupled (EMC) dipoles are described and illustrated with extensive drawings, graphs, and diagrams. The analysis of the radiating element and feeder network is outlined, and a 4 x 1 H-plane array and a 4 x 4 array operating at 11.7-12.5 GHz in linear or circular polarization are characterized in detail. With uniform illumination the latter array had directivity 21.75-22.08 db, gain 20.85-21.27 dB, voltage/standing-wave ratio 1.35-1.55:1, and efficiency 79-85 percent.

  4. Microsecond gain-switched master oscillator power amplifier (1958 nm) with high pulse energy

    SciTech Connect

    Ke Yin; Weiqiang Yang; Bin Zhang; Ying Li; Jing Hou

    2014-02-28

    An all-fibre master oscillator power amplifier (MOPA) emitting high-energy pulses at 1958 nm is presented. The seed laser is a microsecond gain-switched thulium-doped fibre laser (TDFL) pumped with a commercial 1550-nm pulsed fibre laser. The TDFL operates at a repetition rate f in the range of 10 to 100 kHz. The two-stage thulium-doped fibre amplifier is built to scale the energy of the pulses generated by the seed laser. The maximum output pulse energy higher than 0.5 mJ at 10 kHz is achieved which is comparable with the theoretical maximum extractable pulse energy. The slope efficiency of the second stage amplifier with respect to the pump power is 30.4% at f = 10 kHz. The wavelength of the output pulse laser is centred near 1958 nm at a spectral width of 0.25 nm after amplification. Neither nonlinear effects nor significant amplified spontaneous emission (ASE) is observed in the amplification experiments. (lasers)

  5. A novel design of ultra-broadband, high-gain and high-linearity variable gain distributed amplifier in 0.13 μm CMOS technology

    NASA Astrophysics Data System (ADS)

    Baharvand, Zainab; Hakimi, Ahmad; Rashedi, Esmat

    2016-12-01

    A high-gain, high-linearity and ultra-broadband variable gain distributed amplifier (VGDA) based on employing multiple techniques is presented to substantially increase the gain. The complete design is composed of two major parts including a VGDA part followed by a single stage distributed amplifier (SSDA) part. The VGDA part makes it possible to achieve different gain settings. For high gain considerations, the SSDA part cascades with the VGDA part that takes the benefits of the multiplicative gain mechanism. A theory is presented to enhance the linearity without imposing further DC power consumption. This idea has been validated by simulation results as expected. The design is analysed and simulated in the standard 0.13 μm CMOS technology. It presents the large gain tuning range of 35 dB, from -5 dB attenuation gain up to +30 dB maximum amplification gain, in relation to the control voltage (Vctr) that varies between 0.42 and 1.1 V. At the maximum amplification gain setting, it presents a DC up to 16 GHz 3 dB bandwidth, an average noise figure of 3.2 dB and an IIP3 of -2 dB m. Furthermore, it dissipates 46.42 mW from 0.7 and 0.9 V power supplies of the drain lines of VGDA and SSDA parts, respectively. Additionally, the Monte Carlo (MC) simulation has been performed to predict an estimate of the accuracy of performance of the proposed design under various conditions.

  6. Software reconfigurable highly flexible gain switched optical frequency comb source.

    PubMed

    Pascual, M Deseada Gutierrez; Zhou, Rui; Smyth, Frank; Anandarajah, Prince M; Barry, Liam P

    2015-09-07

    The authors present the performance and noise properties of a software reconfigurable, FSR and wavelength tunable gain switched optical frequency comb source. This source, based on the external injection of a temperature tuned Fabry-Pérot laser diode, offers quasi-continuous wavelength tunability over the C-band (30nm) and FSR tunability ranging from 6 to 14GHz. The results achieved demonstrate the excellent spectral quality of the comb tones (RIN ~-130dB/Hz and low phase noise of 300kHz) and its outstanding stability (with fluctuations of the individual comb tones of less than 0.5dB in power and 5pm in wavelength, characterized over 24hours) highlighting its suitability for employment in next generation flexible optical transmission networks.

  7. An S-band high gain relativistic klystron amplifier with high phase stability

    SciTech Connect

    Wu, Y.; Li, Z. H.; Xu, Z.; Ma, Q. S.; Xie, H. Q.

    2014-11-15

    For the purpose of coherent high power microwave combining, an S-band high gain relativistic klystron amplifier with high phase stability is presented and studied. By the aid of 3D particle-in-cell code and circuit simulation software, the mechanism of parasitic oscillation in the device is investigated. And the RF lossy material is adopted in the simulation and experiment to suppress the oscillation. The experimental results show that with an input RF power of 10 kW, a microwave pulse with power of 1.8 GW is generated with a gain of 52.6 dB. And the relative phase difference fluctuation between output microwave and input RF signal is less than ±10° in 90 ns.

  8. High gain durable anti-reflective coating with oblate voids

    DOEpatents

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze'ev

    2016-06-28

    Disclosed herein are single layer transparent coatings with an anti-reflective property, a hydrophobic property, and that are highly abrasion resistant. The single layer transparent coatings contain a plurality of oblate voids. At least 1% of the oblate voids are open to a surface of the single layer transparent coatings.

  9. High gain photoconductive semiconductor switch having tailored doping profile zones

    DOEpatents

    Baca, Albert G.; Loubriel, Guillermo M.; Mar, Alan; Zutavern, Fred J; Hjalmarson, Harold P.; Allerman, Andrew A.; Zipperian, Thomas E.; O'Malley, Martin W.; Helgeson, Wesley D.; Denison, Gary J.; Brown, Darwin J.; Sullivan, Charles T.; Hou, Hong Q.

    2001-01-01

    A photoconductive semiconductor switch with tailored doping profile zones beneath and extending laterally from the electrical contacts to the device. The zones are of sufficient depth and lateral extent to isolate the contacts from damage caused by the high current filaments that are created in the device when it is turned on. The zones may be formed by etching depressions into the substrate, then conducting epitaxial regrowth in the depressions with material of the desired doping profile. They may be formed by surface epitaxy. They may also be formed by deep diffusion processes. The zones act to reduce the energy density at the contacts by suppressing collective impact ionization and formation of filaments near the contact and by reducing current intensity at the contact through enhanced current spreading within the zones.

  10. Primary spontaneous pneumothorax due to high bleb burden.

    PubMed

    Segraves, Justin M; Dulohery, Megan M

    2016-01-01

    Primary spontaneous pneumothorax (PSP) occurs most frequently in young, tall, lean, male smokers without any known underlying lung disease. It is an important diagnosis to make promptly in order to prevent progression to obstructive shock. We present a case report of a young, male, former-smoker and polysubstance abuser with no prior lung history that developed acute dyspnea at rest and was found to have a large right pneumothorax on chest x-ray. A pig-tail catheter was utilized, but his course was complicated by a recurrent tension pneumothorax. Chest computed tomography (CT) revealed a significant bleb burden and the patient underwent a lung wedge resection with mechanical pleurodesis. What made our case unique were the chest x-rays revealing blebs that could have predicted the patient's recurrent pneumothorax as well as the multiple potential risk factors for developing blebs and a pneumothorax. All patients with recurrent PSPs and those with higher risk initial PSPs (e.g. blebs) should undergo preventive therapy with pleurodesis. We hope that clinicians can benefit from utilizing these representative chest x-ray images showing blebs.

  11. Simulation of the short pulse effects in the start-up from noise in high-gain FELS

    SciTech Connect

    Hahn, S.J.; Kim, K.J.

    1995-12-31

    The spatio-temporal evolution of high-gain free electron lasers from noise is investigated by 1-D simulation calculation. To understand the discrepancy between the experimental result and theoretical prediction of the self-amplified spontaneous emission (SASE), the strong slippage effect in the short pulse electron beam and the coherent bunched beam effect are considered. When the length over which the electron density varies significantly is comparable or smaller than the FEL wavelength, the initial noise level would be increased due to the enhanced coherence between electrons. With a proper computer modeling of the start-up from noise including the energy spread, the overall performance and characteristics of SASE are studied. This work will be helpful to increase the credibility of the simulation calculation to predict the SASE performance in all wave-length regions.

  12. High Gain Antenna Gimbal for the 2003-2004 Mars Exploration Rover Program

    NASA Technical Reports Server (NTRS)

    Sokol, Jeff; Krishnan, Satish; Ayari, Laoucet

    2004-01-01

    The High Gain Antenna Assemblies built for the 2003-2004 Mars Exploration Rover (MER) missions provide the primary communication link for the Rovers once they arrive on Mars. The High Gain Antenna Gimbal (HGAG) portion of the assembly is a two-axis gimbal that provides the structural support, pointing, and tracking for the High Gain Antenna (HGA). The MER mission requirements provided some unique design challenges for the HGAG. This paper describes all the major subsystems of the HGAG that were developed to meet these challenges, and the requirements that drove their design.

  13. Design, development and testing of the x-ray timing explorer High Gain Antenna System

    NASA Technical Reports Server (NTRS)

    Lecha, Javier; Woods, Claudia; Phan, Minh

    1995-01-01

    The High Gain Antenna System (HGAS), consisting of two High Gain Antenna Deployment Systems (HGADS) and two Antenna Pointing Systems (APS), is used to position two High Gain Antennas (HGA) on the X-Ray Timing Explorer (XTE). A similar APS will be used on the upcoming Tropical Rainfall Measuring Mission (TRMM). Both XTE and TRMM are NASA in-house satellites. The salient features of the system include the two-axis gimbal and control electronics of the APS and the spring deployment and latch/release mechanisms of the HGADS. This paper describes some of the challenges faced in the design and testing of this system and their resolutions.

  14. HASEonGPU-An adaptive, load-balanced MPI/GPU-code for calculating the amplified spontaneous emission in high power laser media

    NASA Astrophysics Data System (ADS)

    Eckert, C. H. J.; Zenker, E.; Bussmann, M.; Albach, D.

    2016-10-01

    We present an adaptive Monte Carlo algorithm for computing the amplified spontaneous emission (ASE) flux in laser gain media pumped by pulsed lasers. With the design of high power lasers in mind, which require large size gain media, we have developed the open source code HASEonGPU that is capable of utilizing multiple graphic processing units (GPUs). With HASEonGPU, time to solution is reduced to minutes on a medium size GPU cluster of 64 NVIDIA Tesla K20m GPUs and excellent speedup is achieved when scaling to multiple GPUs. Comparison of simulation results to measurements of ASE in Y b 3 + : Y AG ceramics show perfect agreement.

  15. To kill a kangaroo: understanding the decision to pursue high-risk/high-gain resources.

    PubMed

    Jones, James Holland; Bird, Rebecca Bliege; Bird, Douglas W

    2013-09-22

    In this paper, we attempt to understand hunter-gatherer foraging decisions about prey that vary in both the mean and variance of energy return using an expected utility framework. We show that for skewed distributions of energetic returns, the standard linear variance discounting (LVD) model for risk-sensitive foraging can produce quite misleading results. In addition to creating difficulties for the LVD model, the skewed distributions characteristic of hunting returns create challenges for estimating probability distribution functions required for expected utility. We present a solution using a two-component finite mixture model for foraging returns. We then use detailed foraging returns data based on focal follows of individual hunters in Western Australia hunting for high-risk/high-gain (hill kangaroo) and relatively low-risk/low-gain (sand monitor) prey. Using probability densities for the two resources estimated from the mixture models, combined with theoretically sensible utility curves characterized by diminishing marginal utility for the highest returns, we find that the expected utility of the sand monitors greatly exceeds that of kangaroos despite the fact that the mean energy return for kangaroos is nearly twice as large as that for sand monitors. We conclude that the decision to hunt hill kangaroos does not arise simply as part of an energetic utility-maximization strategy and that additional social, political or symbolic benefits must accrue to hunters of this highly variable prey.

  16. To kill a kangaroo: understanding the decision to pursue high-risk/high-gain resources

    PubMed Central

    Jones, James Holland; Bird, Rebecca Bliege; Bird, Douglas W.

    2013-01-01

    In this paper, we attempt to understand hunter–gatherer foraging decisions about prey that vary in both the mean and variance of energy return using an expected utility framework. We show that for skewed distributions of energetic returns, the standard linear variance discounting (LVD) model for risk-sensitive foraging can produce quite misleading results. In addition to creating difficulties for the LVD model, the skewed distributions characteristic of hunting returns create challenges for estimating probability distribution functions required for expected utility. We present a solution using a two-component finite mixture model for foraging returns. We then use detailed foraging returns data based on focal follows of individual hunters in Western Australia hunting for high-risk/high-gain (hill kangaroo) and relatively low-risk/low-gain (sand monitor) prey. Using probability densities for the two resources estimated from the mixture models, combined with theoretically sensible utility curves characterized by diminishing marginal utility for the highest returns, we find that the expected utility of the sand monitors greatly exceeds that of kangaroos despite the fact that the mean energy return for kangaroos is nearly twice as large as that for sand monitors. We conclude that the decision to hunt hill kangaroos does not arise simply as part of an energetic utility-maximization strategy and that additional social, political or symbolic benefits must accrue to hunters of this highly variable prey. PMID:23884091

  17. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect.

    PubMed

    Gosling, Corentin J; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation.

  18. High But Not Low Probability of Gain Elicits a Positive Feeling Leading to the Framing Effect

    PubMed Central

    Gosling, Corentin J.; Moutier, Sylvain

    2017-01-01

    Human risky decision-making is known to be highly susceptible to profit-motivated responses elicited by the way in which options are framed. In fact, studies investigating the framing effect have shown that the choice between sure and risky options depends on how these options are presented. Interestingly, the probability of gain of the risky option has been highlighted as one of the main factors causing variations in susceptibility to the framing effect. However, while it has been shown that high probabilities of gain of the risky option systematically lead to framing bias, questions remain about the influence of low probabilities of gain. Therefore, the first aim of this paper was to clarify the respective roles of high and low probabilities of gain in the framing effect. Due to the difference between studies using a within- or between-subjects design, we conducted a first study investigating the respective roles of these designs. For both designs, we showed that trials with a high probability of gain led to the framing effect whereas those with a low probability did not. Second, as emotions are known to play a key role in the framing effect, we sought to determine whether they are responsible for such a debiasing effect of the low probability of gain. Our second study thus investigated the relationship between emotion and the framing effect depending on high and low probabilities. Our results revealed that positive emotion was related to risk-seeking in the loss frame, but only for trials with a high probability of gain. Taken together, these results support the interpretation that low probabilities of gain suppress the framing effect because they prevent the positive emotion of gain anticipation. PMID:28232808

  19. High-Gain AlxGa1-xAs/GaAs Transistors For Neural Networks

    NASA Technical Reports Server (NTRS)

    Kim, Jae-Hoon; Lin, Steven H.

    1991-01-01

    High-gain AlxGa1-xAs/GaAs npn double heterojunction bipolar transistors developed for use as phototransistors in optoelectronic integrated circuits, especially in artificial neural networks. Transistors perform both photodetection and saturating-amplification functions of neurons. Good candidates for such application because structurally compatible with laser diodes and light-emitting diodes, detect light, and provide high current gain needed to compensate for losses in holographic optical elements.

  20. High-gain weakly nonlinear flux-modulated Josephson parametric amplifier using a SQUID array

    NASA Astrophysics Data System (ADS)

    Zhou, X.; Schmitt, V.; Bertet, P.; Vion, D.; Wustmann, W.; Shumeiko, V.; Esteve, D.

    2014-06-01

    We have developed and measured a high-gain quantum-limited microwave parametric amplifier based on a superconducting lumped LC resonator with the inductor L including an array of eight superconducting quantum interference devices (SQUIDs). This amplifier is parametrically pumped by modulating the flux threading the SQUIDs at twice the resonator frequency. Around 5 GHz, a maximum gain of 31 dB, a product amplitude gain × bandwidth above 60 MHz, and a 1 dB compression point of -123 dBm at 20 dB gain are obtained in the nondegenerate mode of operation. Phase-sensitive amplification-deamplification is also measured in the degenerate mode and yields a maximum gain of 37 dB. The compression point obtained is 18 dB above what would be obtained with a single SQUID of the same inductance, due to the smaller nonlinearity of the SQUID array.

  1. High-precision atom localization via controllable spontaneous emission in a cycle-configuration atomic system.

    PubMed

    Ding, Chunling; Li, Jiahua; Yu, Rong; Hao, Xiangying; Wu, Ying

    2012-03-26

    A scheme for realizing two-dimensional (2D) atom localization is proposed based on controllable spontaneous emission in a coherently driven cycle-configuration atomic system. As the spatial-position-dependent atom-field interaction, the frequency of the spontaneously emitted photon carries the information about the position of the atom. Therefore, by detecting the emitted photon one could obtain the position information available, and then we demonstrate high-precision and high-resolution 2D atom localization induced by the quantum interference between the multiple spontaneous decay channels. Moreover, we can achieve 100% probability of finding the atom at an expected position by choosing appropriate system parameters under certain conditions.

  2. Theta and High-Frequency Activity Mark Spontaneous Recall of Episodic Memories

    PubMed Central

    Burke, John F.; Sharan, Ashwini D.; Sperling, Michael R.; Ramayya, Ashwin G.; Evans, James J.; Healey, M. Karl; Beck, Erin N.; Davis, Kathryn A.; Lucas, Timothy H.

    2014-01-01

    Humans possess the remarkable ability to search their memory, allowing specific past episodes to be re-experienced spontaneously. Here, we administered a free recall test to 114 neurosurgical patients and used intracranial theta and high-frequency activity (HFA) to identify the spatiotemporal pattern of neural activity underlying spontaneous episodic retrieval. We found that retrieval evolved in three electrophysiological stages composed of: (1) early theta oscillations in the right temporal cortex, (2) increased HFA in the left hemisphere including the medial temporal lobe (MTL), left inferior frontal gyrus, as well as the ventrolateral temporal cortex, and (3) motor/language activation during vocalization of the retrieved item. Of these responses, increased HFA in the left MTL predicted recall performance. These results suggest that spontaneous recall of verbal episodic memories involves a spatiotemporal pattern of spectral changes across the brain; however, high-frequency activity in the left MTL represents a final common pathway of episodic retrieval. PMID:25143616

  3. Polarization-insensitive optical gain characteristics of highly stacked InAs/GaAs quantum dots

    SciTech Connect

    Kita, Takashi; Suwa, Masaya; Kaizu, Toshiyuki; Harada, Yukihiro

    2014-06-21

    The polarized optical gain characteristics of highly stacked InAs/GaAs quantum dots (QDs) with a thin spacer layer fabricated on an n{sup +}-GaAs (001) substrate were studied in the sub-threshold gain region. Using a 4.0-nm-thick spacer layer, we realized an electronically coupled QD superlattice structure along the stacking direction, which enabled the enhancement of the optical gain of the [001] transverse-magnetic (TM) polarization component. We systematically studied the polarized electroluminescence properties of laser devices containing 30 and 40 stacked InAs/GaAs QDs. The net modal gain was analyzed using the Hakki-Paoli method. Owing to the in-plane shape anisotropy of QDs, the polarization sensitivity of the gain depends on the waveguide direction. The gain showing polarization isotropy between the TM and transverse-electric polarization components is high for the [110] waveguide structure, which occurs for higher amounts of stacked QDs. Conversely, the isotropy of the [−110] waveguide is easily achieved even if the stacking is relatively low, although the gain is small.

  4. Loop gain stabilizing with an all-digital automatic-gain-control method for high-precision fiber-optic gyroscope.

    PubMed

    Zheng, Yue; Zhang, Chunxi; Li, Lijing; Song, Lailiang; Chen, Wen

    2016-06-10

    For a fiber-optic gyroscope (FOG) using electronic dithers to suppress the dead zone, without a fixed loop gain, the deterministic compensation for the dither signals in the control loop of the FOG cannot remain accurate, resulting in the dither residuals in the FOG rotation rate output and the navigation errors in the inertial navigation system. An all-digital automatic-gain-control method for stabilizing the loop gain of the FOG is proposed. By using a perturbation square wave to measure the loop gain of the FOG and adding an automatic gain control loop in the conventional control loop of the FOG, we successfully obtain the actual loop gain and make the loop gain converge to the reference value. The experimental results show that in the case of 20% variation in the loop gain, the dither residuals are successfully eliminated and the standard deviation of the FOG sampling outputs is decreased from 2.00  deg/h to 0.62  deg/h (sampling period 2.5 ms, 10 points smoothing). With this method, the loop gain of the FOG can be stabilized over the operation temperature range and in the long-time application, which provides a solid foundation for the engineering applications of the high-precision FOG.

  5. Performance studies of high gain photomultiplier having Z-configuration of microchannel plates

    NASA Astrophysics Data System (ADS)

    Lo, C. C.; Leskovar, B.

    1980-11-01

    The characteristics of a high gain type ITT F4129 photomultiplier having three microchannel plates in cascade for electron multiplications were investigated. These plates are in the Z-configuration. Measurements are given of the gain dark current, cathode quantum efficiency, anode pulse linearity, electron transit time, single and multiphoton time spreads, fatigue, and pulse height resolution. The gain as a function of transverse magnetic field was measured and discussed. Photomultiplier characteristics as a function of the input pulse repetition frequency were also investigated and discussed.

  6. Fundamental gain in high-contrast imaging with the large binocular telescope interferometer

    NASA Astrophysics Data System (ADS)

    Patru, Fabien; Esposito, Simone; Puglisi, Alfio; Riccardi, Armando; Pinna, Enrico; Arcidiacono, Carmelo; Hill, John; Hinz, Philip

    2016-08-01

    Numerical simulations for the Large Binocular Telescope Interferometer have shown a fundamental gain in contrast when using two 8m adaptive optics telescopes instead of one, assuming a high Strehl and a cophasing mode. The global gain is improved by a factor 2 in contrast by using the long exposures and by a factor of 10 in contrast by using the short exposures. Indeed, fringes are still present in the short exposure, contrary to the long exposure where the fringes are blurred. Thus, there is some gain in grouping some short exposures with high gain G. This makes the LBTI well suitable for the Angular Differential Imaging technique. A planet will be alternatively located in the dark fringes (G ≈ 10 to 100) and/or in the dark rings (G ≈ 4 to 20). A rotation of 15° is sufficient to pass through at least one gain zone. The LBTI can provide in the visible wavelengths not only high angular resolution (≈ 6:5mas at 750nm) and high sensitivity (by a factor 4), but also a gain in contrast (by a factor 10 to 100) compared to the stand-alone adaptive optics used on each LBT aperture.

  7. DEMONSTRATION OF 3D EFFECTS WITH HIGH GAIN AND EFFICIENCY IN A UV FEL OSCILLATOR

    SciTech Connect

    Stephen Benson; George Biallas; Keith Blackburn; James Boyce; Donald Bullard; James Coleman; Cody Dickover; David Douglas; Forrest Ellingsworth; Pavel Evtushenko; Carlos Hernandez-Garcia; Christopher Gould; Joseph Gubeli; David Hardy; Kevin Jordan; John Klopf; James Kortze; Robert Legg; Matthew Marchlik; Steven Moore; George Neil; Thomas Powers; Daniel Sexton; Michelle D. Shinn; Christopher Tennant; Richard Walker; Anne Watson; Gwyn Williams; Frederick Wilson; Shukui Zhang

    2011-03-01

    We report on the performance of a high gain UV FEL oscillator operating on an energy recovery linac at Jefferson Lab. The high brightness of the electron beam leads to both gain and efficiency that cannot be reconciled with a one-dimensional model. Three-dimensional simulations do predict the performance with reasonable precision. Gain in excess of 100% per pass and an efficiency close to 1/2NW, where NW is the number of wiggler periods, is seen. The laser mirror tuning curves currently permit operation in the wavelength range of 438 to 362 nm. Another mirror set allows operation at longer wavelengths in the red with even higher gain and efficiency.

  8. Higher Flexibility and Better Immediate Spontaneous Correction May Not Gain Better Results for Nonstructural Thoracic Curve in Lenke 5C AIS Patients

    PubMed Central

    Zhang, Yanbin; Lin, Guanfeng; Wang, Shengru; Zhang, Jianguo; Shen, Jianxiong; Wang, Yipeng; Guo, Jianwei; Yang, Xinyu; Zhao, Lijuan

    2016-01-01

    Study Design. Retrospective study. Objective. To study the behavior of the unfused thoracic curve in Lenke type 5C during the follow-up and to identify risk factors for its correction loss. Summary of Background Data. Few studies have focused on the spontaneous behaviors of the unfused thoracic curve after selective thoracolumbar or lumbar fusion during the follow-up and the risk factors for spontaneous correction loss. Methods. We retrospectively reviewed 45 patients (41 females and 4 males) with AIS who underwent selective TL/L fusion from 2006 to 2012 in a single institution. The follow-up averaged 36 months (range, 24–105 months). Patients were divided into two groups. Thoracic curves in group A improved or maintained their curve magnitude after spontaneous correction, with a negative or no correction loss during the follow-up. Thoracic curves in group B deteriorated after spontaneous correction with a positive correction loss. Univariate analysis and multivariate analysis were built to identify the risk factors for correction loss of the unfused thoracic curves. Results. The minor thoracic curve was 26° preoperatively. It was corrected to 13° immediately with a spontaneous correction of 48.5%. At final follow-up it was 14° with a correction loss of 1°. Thoracic curves did not deteriorate after spontaneous correction in 23 cases in group A, while 22 cases were identified with thoracic curve progressing in group B. In multivariate analysis, two risk factors were independently associated with thoracic correction loss: higher flexibility and better immediate spontaneous correction rate of thoracic curve. Conclusion. Posterior selective TL/L fusion with pedicle screw constructs is an effective treatment for Lenke 5C AIS patients. Nonstructural thoracic curves with higher flexibility or better immediate correction are more likely to progress during the follow-up and close attentions must be paid to these patients in case of decompensation. Level of Evidence: 4

  9. Azimuthally unstable resonators for high-power CO[sub 2] lasers with annular gain media

    SciTech Connect

    Ehrlichmann, D.; Habich, U.; Plum, H.D.; Loosen, P.; Herziger, G. )

    1994-06-01

    Stable-unstable resonators have proved suitable for the extraction of a high-quality beam from a gain area that consists of a rectangular slab. Such gain areas have two substantially different transverse dimensions, and the resonators are stable in the small dimension while unstable in the larger one. Using off-axis unstable resonators avoids a central beam obscuration and improves beam quality. The adaptation of stable-unstable resonators to annular gain areas is described in this paper. The resulting resonators are stable in the radial direction and unstable in the azimuthal direction. Different unstable resonators, wound to match the annular geometry, are presented. The resonator modes are calculated numerically using a 3D-diffraction code that considers gain and misalignment. Resonator design parameters are obtained from a geometrical description of the resonator. Experimental results from a diffusion-cooled CO[sub 2] laser confirm theoretical predictions and show that the resonators are capable of extracting beams that are nearly diffraction-limited with high efficiency from an annular gain medium. Output powers of 2 kW have been obtained from a gain length of 1.8 m.

  10. High Gain Submicrometer Optical Amplifier at Near-Infrared Communication Band.

    PubMed

    Wang, Xiaoxia; Zhuang, Xiujuan; Yang, Sen; Chen, Yu; Zhang, Qinglin; Zhu, Xiaoli; Zhou, Hong; Guo, Pengfei; Liang, Junwu; Huang, Yu; Pan, Anlian; Duan, Xiangfeng

    2015-07-10

    Nanoscale near-infrared optical amplification is important but remains a challenge to achieve. Here we report a unique design of silicon and erbium silicate core-shell nanowires for high gain submicrometer optical amplification in the near-infrared communication band. The high refraction index silicon core is used to tightly confine the optical field within the submicron structures, and the single crystalline erbium-ytterbium silicates shell is used as the highly efficient gain medium. Both theoretical and experimental results show that, by systematically tuning the core diameter and shell thickness, a large portion of the optical power can be selectively confined to the erbium silicate shell gain medium to enable a low loss waveguide and high gain optical amplifier. Experimental results further demonstrate that an optimized core-shell nanowire can exhibit an excellent net gain up to 31  dB mm(-1), which is more than 20 times larger than the previously reported best results on the micron-scale optical amplifiers.

  11. Alumni Networks--"An Untapped Potential to Gain and Retain Highly-Skilled Workers?"

    ERIC Educational Resources Information Center

    David, Alexandra; Coenen, Frans

    2014-01-01

    In times of increasing skills shortage, regions and particularly non-core regions, need to attract highly-skilled workers. It is better for these regions to (re)attract highly-skilled workers that gained knowledge and contacts elsewhere and because they once lived in the region for study have already ties to the university region than trying to…

  12. Steady State Analysis of Short-wavelength, High-gainFELs in a Large Storage Ring

    SciTech Connect

    Huang, Z.; Bane, K.; Cai, Y.; Chao, A.; Hettel, R.; Pellegrini, C.; /UCLA

    2007-10-15

    Storage ring FELs have operated successfully in the low-gain regime using optical cavities. Discussions of a high-gain FEL in a storage ring typically involve a special bypass to decouple the FEL interaction from the storage ring dynamics. In this paper, we investigate the coupled dynamics of a high-gain FEL in a large storage ring such as PEP and analyze the equilibrium solution. We show that an FEL in the EUV and soft x-ray regimes can be integrated into a very bright storage ring and potentially provides three orders of magnitude improvement in the average brightness at these radiation wavelengths. We also discuss possibilities of seeding with HHG sources to obtain ultra-short, high-peak power EUV and soft x-ray pulses.

  13. Orbital angular momentum modes of high-gain parametric down-conversion

    NASA Astrophysics Data System (ADS)

    Beltran, Lina; Frascella, Gaetano; Perez, Angela M.; Fickler, Robert; Sharapova, Polina R.; Manceau, Mathieu; Tikhonova, Olga V.; Boyd, Robert W.; Leuchs, Gerd; Chekhova, Maria V.

    2017-04-01

    Light beams with orbital angular momentum (OAM) are convenient carriers of quantum information. They can also be used for imparting rotational motion to particles and providing high resolution in imaging. Due to the conservation of OAM in parametric down-conversion (PDC), signal and idler photons generated at low gain have perfectly anti-correlated OAM values. It is interesting to study the OAM properties of high-gain PDC, where the same OAM modes can be populated with large, but correlated, numbers of photons. Here we investigate the OAM spectrum of high-gain PDC and show that the OAM mode content can be controlled by varying the pump power and the configuration of the source. In our experiment, we use a source consisting of two nonlinear crystals separated by an air gap. We discuss the OAM properties of PDC radiation emitted by this source and suggest possible modifications.

  14. High-Resolution Electronics: Spontaneous Patterning of High-Resolution Electronics via Parallel Vacuum Ultraviolet (Adv. Mater. 31/2016).

    PubMed

    Liu, Xuying; Kanehara, Masayuki; Liu, Chuan; Sakamoto, Kenji; Yasuda, Takeshi; Takeya, Jun; Minari, Takeo

    2016-08-01

    On page 6568, T. Minari and co-workers describe spontaneous patterning based on the parallel vacuum ultraviolet (PVUV) technique, enabling the homogeneous integration of complex, high-resolution electronic circuits, even on large-scale, flexible, transparent substrates. Irradiation of PVUV to the hydrophobic polymer surface precisely renders the selected surface into highly wettable regions with sharply defined boundaries, which spontaneously guides a metal nanoparticle ink into a series of circuit lines and gaps with the widths down to a resolution of 1 μm.

  15. Balancing high gain and bandwidth in multilayer organic photodetectors with tailored carrier blocking layers

    NASA Astrophysics Data System (ADS)

    Hammond, William T.; Mudrick, John P.; Xue, Jiangeng

    2014-12-01

    We present detailed studies of the high photocurrent gain behavior in multilayer organic photodiodes containing tailored carrier blocking layers we reported earlier in a Letter [W. T. Hammond and J. Xue, Appl. Phys. Lett. 97, 073302 (2010)], in which a high photocurrent gain of up to 500 was attributed to the accumulation of photogenerated holes at the anode/organic active layer interface and the subsequent drastic increase in secondary electron injection from the anode. Here, we show that both the hole-blocking layer structure and layer thickness strongly influence the magnitude of the photocurrent gain. Temporal studies revealed that the frequency response of such devices is limited by three different processes with lifetimes of 10 μs, 202 μs, and 2.72 ms for the removal of confined holes, which limit the 3 dB bandwidth of these devices to 1.4 kHz. Furthermore, the composition in the mixed organic donor-acceptor photoactive layer affects both gain and bandwidth, which is attributed to the varying charge transport characteristics, and the optimal gain-bandwidth product is achieved with approximately 30% donor content. Finally, these devices show a high dynamic range of more than seven orders of magnitude, although the photocurrent shows a sublinear dependence on the incident optical power.

  16. Balancing high gain and bandwidth in multilayer organic photodetectors with tailored carrier blocking layers

    SciTech Connect

    Hammond, William T.; Mudrick, John P.; Xue, Jiangeng

    2014-12-07

    We present detailed studies of the high photocurrent gain behavior in multilayer organic photodiodes containing tailored carrier blocking layers we reported earlier in a Letter [W. T. Hammond and J. Xue, Appl. Phys. Lett. 97, 073302 (2010)], in which a high photocurrent gain of up to 500 was attributed to the accumulation of photogenerated holes at the anode/organic active layer interface and the subsequent drastic increase in secondary electron injection from the anode. Here, we show that both the hole-blocking layer structure and layer thickness strongly influence the magnitude of the photocurrent gain. Temporal studies revealed that the frequency response of such devices is limited by three different processes with lifetimes of 10 μs, 202 μs, and 2.72 ms for the removal of confined holes, which limit the 3 dB bandwidth of these devices to 1.4 kHz. Furthermore, the composition in the mixed organic donor-acceptor photoactive layer affects both gain and bandwidth, which is attributed to the varying charge transport characteristics, and the optimal gain-bandwidth product is achieved with approximately 30% donor content. Finally, these devices show a high dynamic range of more than seven orders of magnitude, although the photocurrent shows a sublinear dependence on the incident optical power.

  17. Doped Contacts for High-Longevity Optically Activated, High Gain GaAs Photoconductive Semiconductor Switches

    SciTech Connect

    Baca, A.G.; Brown, D.J.; Donaldson, R.D.; Helgeson, W.D.; Hjalmarson, H.P.; Loubriel, G.M.; Mar, A.; O'Malley, M.W.; Thornton, R.L.; Zutavern, F.J.

    1999-08-05

    The longevity of high gain GaAs photoconductive semiconductor switches (PCSS) has been extended to over 50 million pulses. This was achieved by improving the ohmic contacts through the incorporation of a doped layer beneath the PCSS contacts which is very effective in the suppression of filament formation and alleviating current crowding to improve the longevity of PCSS. Virtually indefinite, damage-free operation is now possible at much higher current levels than before. The inherent damage-free current capacity of the switch depends on the thickness of the doped layers and is at least 100A for a dopant diffusion depth of 4pm. The contact metal has a different damage mechanism and the threshold for damage ({approximately}40A) is not further improved beyond a dopant diffusion depth of about 2{micro}m. In a diffusion-doped contact switch, the switching performance is not degraded when contact metal erosion occurs. This paper will compare thermal diffusion and epitaxial growth as approaches to doping the contacts. These techniques will be contrasted in terms of the fabrication issues and device characteristics.

  18. Doped Contacts for High-Longevity Optically Activated, High Gain GaAs Photoconductive Semiconductor Switches

    SciTech Connect

    MAR,ALAN; LOUBRIEL,GUILLERMO M.; ZUTAVERN,FRED J.; O'MALLEY,MARTIN W.; HELGESON,WESLEY D.; BROWN,DARWIN JAMES; HJALMARSON,HAROLD P.; BACA,ALBERT G.; THORNTON,R.L.; DONALDSON,R.D.

    1999-12-17

    The longevity of high gain GaAs photoconductive semiconductor switches (PCSS) has been extended to over 100 million pulses. This was achieved by improving the ohmic contacts through the incorporation of a doped layer that is very effective in the suppression of filament formation, alleviating current crowding. Damage-free operation is now possible with virtually infinite expected lifetime at much higher current levels than before. The inherent damage-free current capacity of the bulk GaAs itself depends on the thickness of the doped layers and is at least 100A for a dopant diffusion depth of 4pm. The contact metal has a different damage mechanism and the threshold for damage ({approx}40A) is not further improved beyond a dopant diffusion depth of about 2{micro}m. In a diffusion-doped contact switch, the switching performance is not degraded when contact metal erosion occurs, unlike a switch with conventional contacts. This paper will compare thermal diffusion and epitaxial growth as approaches to doping the contacts. These techniques will be contrasted in terms of the fabrication issues and device characteristics.

  19. Spontaneous Steinbeck: The Influence of Arts Integration, Primarily Spontaneous Painting, on the Reader Response of High School Juniors to "The Grapes of Wrath"

    ERIC Educational Resources Information Center

    Klasek, Catherine Huey

    2010-01-01

    This paper addresses my experience with a group of 11th grade students and their reading of The Grapes of Wrath (1939, 2002) by John Steinbeck. I questioned how the application of visual arts integration strategies, specifically the use of spontaneously created paintings, might influence the reader responses of my high school junior-level…

  20. Highly enhanced spontaneous emission with nanoshell-based metallodielectric hybrid antennas

    NASA Astrophysics Data System (ADS)

    Cheng, Yuqing; Lu, Guowei; shen, Hongming; Wang, Yuwei; He, Yingbo; Chou, R. Yuanying; Gong, Qihuang

    2015-09-01

    The metallodielectric hybrid nanoantenna integrating plasmonic nanostructures with dielectric planar substrate can improve the spontaneous emission greatly. We demonstrated that the performances of the hybrid antenna can be substantially optimized with specific plasmonic nanostructures by employing finite-difference time-domain method. The hybrid antenna with core-shell nanostructure can enhance spontaneous emission greatly rather than the individual spherical nanoparticle. Moreover, the performances of the hybrid antenna can be boosted further through using asymmetrical nanoshell. The mechanism of the high enhancement effect is due to the hybrid structure being able to couple efficiently with the electric field by a larger dipolar moment. And the emission directivity of the hybrid antenna is able to be modified by adjusting the geometry of the plasmonic nanostructures. The results should be beneficial for various fundamental and applied research fields, including single molecule fluorescence and surface enhance Raman spectroscopy, etc. The enhancement of spontaneous emission is in demand in fundamental interests and various applied research fields. However, the electromagnetic enhancement of single plasmonic nanostructure is limited due to intrinsic loss of metal materials and quantum tunneling effect which also limits the ability of enhancement of spontaneous emission. Interestingly, it was found that hybrid structures can provide higher enhancement effect. This study is about a kind new type of optical antenna to control spontaneous emission of single emitter, i.e. a metallodielectric hybrid nanoantenna integrating plasmonic nanostructures with dielectric planar substrate which can improve the spontaneous emission greatly. We demonstrated that the performances of the hybrid antenna can be substantially optimized with specific plasmonic nanostructures by employing finite-difference time-domain method. The hybrid antenna with core-shell nanostructure can enhance

  1. Application of variable-gain output feedback for high-alpha control

    NASA Technical Reports Server (NTRS)

    Ostroff, Aaron J.

    1990-01-01

    A variable-gain, optimal, discrete, output feedback design approach that is applied to a nonlinear flight regime is described. The flight regime covers a wide angle-of-attack range that includes stall and post stall. The paper includes brief descriptions of the variable-gain formulation, the discrete-control structure and flight equations used to apply the design approach, and the high performance airplane model used in the application. Both linear and nonlinear analysis are shown for a longitudinal four-model design case with angles of attack of 5, 15, 35, and 60 deg. Linear and nonlinear simulations are compared for a single-point longitudinal design at 60 deg angle of attack. Nonlinear simulations for the four-model, multi-mode, variable-gain design include a longitudinal pitch-up and pitch-down maneuver and high angle-of-attack regulation during a lateral maneuver.

  2. Recent progress in high gain InAs avalanche photodiodes (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Bank, Seth; Maddox, Scott J.; Sun, Wenlu; Nair, Hari P.; Campbell, Joe C.

    2015-08-01

    InAs possesses nearly ideal material properties for the fabrication of near- and mid-infrared avalanche photodiodes (APDs), which result in strong electron-initiated impact ionization and negligible hole-initiated impact ionization [1]. Consequently, InAs multiplication regions exhibit several appealing characteristics, including extremely low excess noise factors and bandwidth independent of gain [2], [3]. These properties make InAs APDs attractive for a number of near- and mid-infrared sensing applications including remote gas sensing, light detection and ranging (LIDAR), and both active and passive imaging. Here, we discuss our recent advances in the growth and fabrication of high gain, low noise InAs APDs. Devices yielded room temperature multiplication gains >300, with much reduced (~10x) lower dark current densities. We will also discuss a likely key contributor to our current performance limitations: silicon diffusion into the intrinsic (multiplication) region from the underlying n-type layer during growth. Future work will focus on increasing the intrinsic region thickness, targeting gains >1000. This work was supported by the Army Research Office (W911NF-10-1-0391). [1] A. R. J. Marshall, C. H. Tan, M. J. Steer, and J. P. R. David, "Electron dominated impact ionization and avalanche gain characteristics in InAs photodiodes," Applied Physics Letters, vol. 93, p. 111107, 2008. [2] A. R. J. Marshall, A. Krysa, S. Zhang, A. S. Idris, S. Xie, J. P. R. David, and C. H. Tan, "High gain InAs avalanche photodiodes," in 6th EMRS DTC Technical Conference, Edinburgh, Scotland, UK, 2009. [3] S. J. Maddox, W. Sun, Z. Lu, H. P. Nair, J. C. Campbell, and S. R. Bank, "Enhanced low-noise gain from InAs avalanche photodiodes with reduced dark current and background doping," Applied Physics Letters, vol. 101, no. 15, pp. 151124-151124-3, Oct. 2012.

  3. Comparative analysis of the intrinsic voltage gain and unit gain frequency between SOI and bulk FinFETs up to high temperatures

    NASA Astrophysics Data System (ADS)

    Oliveira, Alberto Vinicius de; Agopian, Paula Ghedini Der; Martino, Joao Antonio; Simoen, Eddy; Claeys, Cor; Collaert, Nadine; Thean, Aaron

    2016-09-01

    This paper presents an experimental analysis of the analog application figures of merit: the intrinsic voltage gain (AV) and unit gain frequency, focusing on the performance comparison between silicon triple gate pFinFET devices, which were processed on both Si and Silicon-On-Insulator (SOI) substrates. The high temperature (from 25 °C to 150 °C) influence and different channel lengths and fin widths were also taken into account. While the temperature impact on the intrinsic voltage gain (AV) is limited, the unit gain frequency was strongly affected due to the carrier mobility degradation at higher temperatures, for both p- and n-type FinFET structures. In addition, the pFinFETs showed slightly larger AV values compared to the n-type counterparts, whereby the bulk FinFETs presented a higher dispersion than the SOI FinFETs.

  4. Teachers' Responses to High-Stakes Testing and the Validity of Gains: A Pilot Study. CSE Report.

    ERIC Educational Resources Information Center

    Koretz, Daniel M.; Hamilton, Laura S.

    Previous studies of the validity of gains on high-stakes tests have compared trends in scores on a high-stakes test to trends on a lower-stakes test, such as NAEP. However, generalizability of gains is likely to be incomplete even when gains are meaningful because of differences in the inferences the two tests are designed to support. Therefore,…

  5. Highly elevated emission of mercury vapor due to the spontaneous combustion of refuse in a landfill

    NASA Astrophysics Data System (ADS)

    Zhu, Wei; Sommar, Jonas; Li, Zhonggen; Feng, Xinbin; Lin, Che-Jen; Li, Guanghui

    2013-11-01

    Refuse disposal (e.g., landfilling and incineration) have been recognized as a significant anthropogenic source of mercury (Hg) emission globally. However, in-situ measurements of Hg emission from landfill or refuse dumping sites where fugitive spontaneous combustion occurs have not been reported. Gaseous elemental mercury (Hg0) concentration and emission flux were observed near spontaneous combustions of refuse at a landfill site in southwestern China. Ambient Hg0 concentrations above the refuse surface ranged from 42.7 ± 20.0 to 396.4 ± 114.2 ng m-3, up to 10 times enhancement due to the spontaneous burning. Using a box model with Hg0 data obtained from 2004 to 2013, we estimated that the Hg0 emission from refuse was amplified by 8-40 times due to spontaneous combustion. A micrometeorological flux measurement system based on relaxed eddy accumulation was configured downwind of the combustion sites to quantify the Hg0 emission. Extremely large turbulent deposition fluxes (up to -128.6 μg m-2 h-1, 20 min average) were detected during periods of high Hg0 concentration events over the measurement footprint. The effect of temperature, moisture and light on the air-surface exchange of Hg0 exchange was found to be masked by the overwhelming deposition of Hg0 from the enriched air from the refuse combustion plumes. This research reveals that mercury emission from the landfill refuse can be boosted by fugitive spontaneous combustion of refuse. The emission represents an anthropogenic source that has been overlooked in Hg inventory estimates.

  6. High-Current Gain Two-Dimensional MoS₂-Base Hot-Electron Transistors.

    PubMed

    Torres, Carlos M; Lan, Yann-Wen; Zeng, Caifu; Chen, Jyun-Hong; Kou, Xufeng; Navabi, Aryan; Tang, Jianshi; Montazeri, Mohammad; Adleman, James R; Lerner, Mitchell B; Zhong, Yuan-Liang; Li, Lain-Jong; Chen, Chii-Dong; Wang, Kang L

    2015-12-09

    The vertical transport of nonequilibrium charge carriers through semiconductor heterostructures has led to milestones in electronics with the development of the hot-electron transistor. Recently, significant advances have been made with atomically sharp heterostructures implementing various two-dimensional materials. Although graphene-base hot-electron transistors show great promise for electronic switching at high frequencies, they are limited by their low current gain. Here we show that, by choosing MoS2 and HfO2 for the filter barrier interface and using a noncrystalline semiconductor such as ITO for the collector, we can achieve an unprecedentedly high-current gain (α ∼ 0.95) in our hot-electron transistors operating at room temperature. Furthermore, the current gain can be tuned over 2 orders of magnitude with the collector-base voltage albeit this feature currently presents a drawback in the transistor performance metrics such as poor output resistance and poor intrinsic voltage gain. We anticipate our transistors will pave the way toward the realization of novel flexible 2D material-based high-density, low-energy, and high-frequency hot-carrier electronic applications.

  7. 75 FR 61228 - Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR WASTE TECHNICAL REVIEW BOARD Board Meeting: Technical Lessons Gained From High-Level Nuclear Waste Disposal Efforts Pursuant to its authority under section 5051 of Public Law 100-203, Nuclear Waste Policy Amendments Act...

  8. Measuring the rates of spontaneous vortex formation in highly oblate Bose-Einstein condensates

    NASA Astrophysics Data System (ADS)

    Neely, Tyler; Samson, Edward; Bradley, Ashton; Davis, Matthew; Anderson, Brian

    2009-05-01

    By studying the dynamics of the Bose-Einstein condensation transition in highly oblate (˜11:1 aspect ratio) traps, we have measured the dependence of spontaneous vortex formation on BEC growth rate, extending our previous experimental and numerical observations of spontaneous vortex formation in weakly oblate (˜2:1 aspect ratio) traps [1]. Our condensation procedure in these highly oblate traps allows us to create BECs over a large range of growth times, from approximately 200 ms to over 2 s. By characterizing vortex formation vs. BEC growth rate, and comparing experimental and numerical results, the Kibble-Zurek mechanism for topological defect formation may be quantitatively studied in our system. [1] C.N. Weiler, T.W. Neely, D.R. Scherer, A.S. Bradley, M.J. Davis, and B.P. Anderson., Nature 455, 948 (2008).

  9. A spontaneous high-grade undifferentiated mammary carcinoma in a seven-week-old female rat.

    PubMed

    Faustino-Rocha, Ana I; Gama, Adelina; Oliveira, Paula A; Alvarado, Antonieta; Ferreira, Rita; Ginja, Mário

    2017-02-01

    The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α. The histopathologic and immunohistochemical data are suggestive of a high-grade carcinoma from mammary gland. It was the first report of a spontaneous mammary tumor in such a young rat.

  10. High Average Power Laser Gain Medium With Low Optical Distortion Using A Transverse Flowing Liquid Host

    DOEpatents

    Comaskey, Brian J.; Ault, Earl R.; Kuklo, Thomas C.

    2005-07-05

    A high average power, low optical distortion laser gain media is based on a flowing liquid media. A diode laser pumping device with tailored irradiance excites the laser active atom, ion or molecule within the liquid media. A laser active component of the liquid media exhibits energy storage times longer than or comparable to the thermal optical response time of the liquid. A circulation system that provides a closed loop for mixing and circulating the lasing liquid into and out of the optical cavity includes a pump, a diffuser, and a heat exchanger. A liquid flow gain cell includes flow straighteners and flow channel compression.

  11. Long wavelength, high gain InAsSb strained-layer superlattice photoconductive detectors

    DOEpatents

    Biefeld, Robert M.; Dawson, L. Ralph; Fritz, Ian J.; Kurtz, Steven R.; Zipperian, Thomas E.

    1991-01-01

    A high gain photoconductive device for 8 to 12 .mu.m wavelength radiation including an active semiconductor region extending from a substrate to an exposed face, the region comprising a strained-layer superlattice of alternating layers of two different InAs.sub.1-x Sb.sub.x compounds having x>0.75. A pair of spaced electrodes are provided on the exposed face, and changes in 8 to 12 .mu.m radiation on the exposed face cause a large photoconductive gain between the spaced electrodes.

  12. Spontaneous Patterning of High-Resolution Electronics via Parallel Vacuum Ultraviolet.

    PubMed

    Liu, Xuying; Kanehara, Masayuki; Liu, Chuan; Sakamoto, Kenji; Yasuda, Takeshi; Takeya, Jun; Minari, Takeo

    2016-08-01

    A spontaneous patterning technique via parallel vacuum ultraviolet is developed for fabricating large-scale, complex electronic circuits with 1 μm resolution. The prepared organic thin-film transistors exhibit a low contact resistance of 1.5 kΩ cm, and high mobilities of 0.3 and 1.5 cm(2) V(-1) s(-1) in the devices with channel lengths of 1 and 5 μm, respectively.

  13. High current gain 4H-SiC bipolar junction transistor

    NASA Astrophysics Data System (ADS)

    Yourun, Zhang; Jinfei, Shi; Ying, Liu; Chengchun, Sun; Fei, Guo; Bo, Zhang

    2016-04-01

    A novel 4H-SiC BJT of high current gain with a suppressing surface traps effect has been proposed. It is effective to improve the current gain due to the lower electrons density in the surface region by extending the emitter metal to overlap the passivation layer on the extrinsic base surface. The electrons trapped in the extrinsic base surface induce the degeneration of SiC BJTs device performance. By modulating the electron recombination rate, the novel structure can increase the current gain to 63.2% compared with conventional ones with the compatible process technology. Optimized sizes are an overlapped metal length of 4 μm, as well as an oxide layer thickness of 50 nm. Project supported by the National Natural Science Foundation of China (Nos. 61306093, 61401075).

  14. Design of anisotropic focusing metasurface and its application for high-gain lens antenna

    NASA Astrophysics Data System (ADS)

    Guo, Wenlong; Wang, Guangming; Li, Haipeng; Li, Tangjing; Ge, Qichao; Zhuang, Yaqiang

    2017-03-01

    In this paper, we propose an anisotropic focusing metasurface with function of focusing orthogonally polarized waves in refraction and reflection modes respectively. By employing four layered metallic patches spaced by triple layered dielectric spacers, an anisotropic phase element is designed with capability of transmitting x-polarized waves but reflecting y-polarized beams efficiently. Composed of 21 × 21 cells and with size of 105 × 105 mm2, a focusing metasurface operating at 15 GHz is designed with the same focal length of 30 mm for x- and y-polarized waves. By setting a patch antenna at the focal point, the metasurface sample is employed to enhance gain of the radiation source. For verification, the metasurface sample is fabricated and measured. The antenna performance, in terms of realized boresight gain and operating bandwidth under x- and y-polarized waves illumination, is presented. Results show that the 1 dB gain bandwidths are respectively from 14.7 to 15.3 GHz and 14.7 to 15.2 GHz, and the gain are enhanced by 14.1 dB, 15.1 dB in refraction and reflection modes when the metasurface is impinged by x- and y-polarized spherical waves. The proposed anisotropic metasurface may afford an alternative for designing anisotropic planar lens or high-gain antenna.

  15. Microcavity Laser Based on a Single Molecule Thick High Gain Layer.

    PubMed

    Palatnik, Alexander; Aviv, Hagit; Tischler, Yaakov R

    2017-04-05

    The ability to confine excitons within monolayers has led to fundamental investigations of non-radiative energy transfer, super-radiance, strong light-matter coupling, high-efficiency LEDs, and recently lasers in lateral resonator architectures. Vertical Cavity Surface Emitting Lasers (VCSELs), in which lasing occurs perpendicular to the device plane, are critical for telecommunications and large-scale photonics integration, however strong optical self-absorption and low fluorescence quantum yields have thus far prevented coherent emission from a monolayer microcavity device. Here we show lasing from a monolayer VCSEL using a single molecule thick film of amphiphilic fluorescent dye, assembled via Langmuir-Blodgett deposition, as the gain layer. Threshold was observed when 5% of the molecules were excited (4.4 μJ/cm(2)). At this level of excitation, the optical gain in the monolayer exceeds 1056 cm(-1). High localization of the excitons in the VCSEL gain layer can enhance their collective emission properties with Langmuir-Blodgett deposition presenting a paradigm for engineering the high gain layers on the molecular level.

  16. High gain GaAs photoconductive semiconductor switches for ground penetrating radar

    SciTech Connect

    Loubriel, G.M.; Aurand, J.F.; Buttram, M.T.; Zutavern, F.J.; Helgeson, W.D.; O`Malley, M.W.; Brown, D.J.

    1996-07-01

    The ability of high gain GaAs Photoconductive Semiconductor switches (PCSS) to deliver high peak power, fast risetime pulses when triggered with small laser diode arrays makes them suitable for their use in radars that rely on fast impulses. This type of direct time domain radar is uniquely suited for observation of large structures under ground because it can operate at low frequencies and at high average power. This paper will summarize the state-of-the-art in high gain GaAs switches and discuss their use in a radar transmitter. We will also present a summary of an analysis of the effectiveness of different pulser geometries that result in transmitted pulses with varying frequency content. To this end we developed a simple model that includes transmit and receive antenna response, attenuation and dispersion of the electromagnetic impulses by the soil, and target cross sections.

  17. High-gain visual feedback exacerbates ankle movement variability in children.

    PubMed

    Moon, Hwasil; Kim, Changki; Kwon, MinHyuk; Chen, Yen-Ting; Fox, Emily; Christou, Evangelos A

    2015-05-01

    The purpose was to compare the effect of low- and high-gain visual feedback on ankle movement variability and muscle activation in children and young adults. Six young adults (19.8 ± 0.6 years) and nine children (9.4 ± 1.6 years) traced a sinusoidal target by performing ankle plantar/dorsiflexion movements. The targeted range of motion was 10°, and the frequency of the sinusoidal target was 0.4 Hz for 35 s. Low-gain visual feedback was 0.66°, and high-gain visual feedback was 4.68°. Surface EMG was recorded from the tibialis anterior (TA) muscle. Movement variability amplitude was quantified as the standard deviation of the position fluctuations after the task frequency was removed with a notch filter (second-order; 0.3-0.5 Hz). We quantified the oscillations in movement variability and TA EMG burst using the following frequency bands: 0-0.3, 0.3-0.6, 0.6-0.9, 0.9-1.2, and 1.2-1.5 Hz. Children exhibited greater movement variability than young adults, which was exacerbated during the high-gain visual feedback condition (P < 0.05). The greater ankle movement variability in children at the high-gain visual feedback condition was predicted by greater power within the 0-0.3 Hz of their movement variability (R (2) = 0.51, P < 0.001). The greater power in movement variability from 0 to 0.3 Hz in children was predicted by greater power within the 0-0.3 Hz in their TA EMG burst activity (R (2) = 0.6, P < 0.001). The observed deficiency in movement control with amplified visual feedback in children may be related to an ineffective use of visual feedback and the immaturity of the cortico-motor systems.

  18. High gain, Fast Scan, Broad Spectrum Parallel Beam Wavelength Dispersive X-ray Spectrometer for SEM

    SciTech Connect

    OHara, David

    2009-05-08

    During contract # DE-FG02-ER83545, Parallax Research, Inc. developed a High gain, Fast Scan Broad Spectrum Parallel beam Wavelength Dispersive X-ray Spectrometer for use on Scanning Electron Microscopes (SEM). This new spectrometer allows very fast high resolution elemental analysis of samples in an electron microscope. By comparison to previous WDS spectrometers, it can change from one energy position to another very quickly and has an extended range compared to some similar products.

  19. Parameter analysis for a high-gain harmonic generation FEL using a recently developed 3D polychromatic code.

    SciTech Connect

    Biedron, S. G.; Freund, H. P.; Yu, L.-H.

    1999-09-10

    One possible design for a fourth-generation light source is the high-gain harmonic generation (HGHG) free-electron laser (FEL). Here, a coherent seed with a wavelength at a subharmonic of the desired output radiation interacts with the electron beam in an energy-modulating section. This energy modulation is then converted into spatial bunching while traversing a dispersive section (a three-dipole chicane). The final step is passage through a radiative section, an undulator tuned to the desired higher harmonic output wavelength. The coherent seed serves to remove noise and can be at a much lower subharmonic of the output radiation, thus eliminating the concerns found in self-amplified spontaneous emission (SASE) and seeded FELs, respectively. Recently, a 3D code that includes multiple frequencies, multiple undulatory (both in quantity and/or type), quadruple magnets, and dipole magnets was developed to easily simulate HGHG. Here, a brief review of the HGHG theory, the code development, the Accelerator Test Facility's (ATF) HGHG FEL experimental parameters, and the parameter analysis from simulations of this specific experiment will be discussed.

  20. Gain and noise characteristics of high-bit-rate silicon parametric amplifiers.

    PubMed

    Sang, Xinzhu; Boyraz, Ozdal

    2008-08-18

    We report a numerical investigation on parametric amplification of high-bit-rate signals and related noise figure inside silicon waveguides in the presence of two-photon absorption (TPA), TPA-induced free-carrier absorption, free-carrier-induced dispersion and linear loss. Different pump parameters are considered to achieve net gain and low noise figure. We show that the net gain can only be achieved in the anomalous dispersion regime at the high-repetition-rate, if short pulses are used. An evaluation of noise properties of parametric amplification in silicon waveguides is presented. By choosing pulsed pump in suitably designed silicon waveguides, parametric amplification can be a chip-scale solution in the high-speed optical communication and optical signal processing systems.

  1. Highly compact neutron stars in scalar-tensor theories of gravity: Spontaneous scalarization versus gravitational collapse

    NASA Astrophysics Data System (ADS)

    Mendes, Raissa F. P.; Ortiz, Néstor

    2016-06-01

    Scalar-tensor theories of gravity are extensions of general relativity (GR) including an extra, nonminimally coupled scalar degree of freedom. A wide class of these theories, albeit indistinguishable from GR in the weak field regime, predicts a radically different phenomenology for neutron stars, due to a nonperturbative, strong-field effect referred to as spontaneous scalarization. This effect is known to occur in theories where the effective linear coupling β0 between the scalar and matter fields is sufficiently negative, i.e. β0≲-4.35 , and has been strongly constrained by pulsar timing observations. In the test-field approximation, spontaneous scalarization manifests itself as a tachyonic-like instability. Recently, it was argued that, in theories where β0>0 , a similar instability would be triggered by sufficiently compact neutron stars obeying realistic equations of state. In this work we investigate the end state of this instability for some representative coupling functions with β0>0 . This is done both through an energy balance analysis of the existing equilibrium configurations, and by numerically determining the nonlinear Cauchy development of unstable initial data. We find that, contrary to the β0<0 case, the final state of the instability is highly sensitive to the details of the coupling function, varying from gravitational collapse to spontaneous scalarization. In particular, we show, for the first time, that spontaneous scalarization can happen in theories with β0>0 , which could give rise to novel astrophysical tests of the theory of gravity.

  2. CMOS highly linear direct-conversion transmitter for WCDMA with fine gain accuracy

    NASA Astrophysics Data System (ADS)

    Xin, Li; Jian, Fu; Yumei, Huang; Zhiliang, Hong

    2011-08-01

    A highly linear, high output power, 0.13 μm CMOS direct conversion transmitter for wideband code division multiple access (WCDMA) is described. The transmitter delivers 6.8 dBm output power with 38 mA current consumption. With careful design on the resistor bank in the IQ-modulator, the gain step accuracy is within 0.1 dB, hence the image rejection ratio can be kept below -47 dBc for the entire output range. The adjacent channel leakage ratio and the LO leakage at 6.8 dBm output power are -44 dBc @ 5 MHz and -37 dBc, respectively, and the corresponding EVM is 3.6%. The overall gain can be programmed in 6 dB steps in a 66-dB range.

  3. High power double-scale pulses from a gain-guided double-clad fiber laser

    NASA Astrophysics Data System (ADS)

    Zhang, Haitao; Gao, Gan; Li, Qinghua; Gong, Mali

    2017-03-01

    Generation of high power double-scale pulses from a gain-guided double-clad fiber laser is experimentally demonstrated. By employing the Yb-doped 10/130 double-clad fiber as the gain medium, the laser realizes an output power of 5.1 W and pulse energy of 0.175 µJ at repetition rate of 29.14 MHz. To the best of our knowledge, this average output power is the highest among the reported double-scale pulse oscillators. The autocorrelation trace of pulses contains the short (98 fs) and long (29.5 ps) components, and the spectral bandwidth of the pulse is 27.3 nm. Such double-scale pulses are well suited for seeding the high power MOPA (master oscillator power amplifier) systems, nonlinear frequency conversion and optical coherence tomography.

  4. Mode control in a high gain relativistic klystron amplifier with 3 GW output power

    NASA Astrophysics Data System (ADS)

    Wu, Yang; Xie, Hong-Quan; Xu, Zhou

    2014-01-01

    Higher mode excitation is very serious in the relativistic klystron amplifier, especially for the high gain relativistic amplifier working at tens of kilo-amperes. The mechanism of higher mode excitation is explored in the PIC simulation and it is shown that insufficient separation of adjacent cavities is the main cause of higher mode excitation. So RF lossy material mounted on the drift tube wall is adopted to suppress higher mode excitation. A high gain S-band relativistic klystron amplifier is designed for the beam current of 13 kA and the voltage of 1 MV. PIC simulation shows that the output power is 3.2 GW when the input power is only 2.8 kW.

  5. Nonlinear harmonic generation in high-gain free-electron lasers

    SciTech Connect

    Dattoli, G.; Ottaviani, P.L.; Pagnutti, S.

    2005-06-01

    We reconsider the derivation of semianalytical expressions providing the most significant aspects of the high-gain free-electron laser dynamics. We obtain new expressions for the growth of the laser power, of the e-beam-induced energy spread, and of the higher-order nonlinearly generated harmonics. The procedure we employ, based on theoretical ansatz and fitting methods, allows the determination of crucial quantities like the expected harmonic output power and its dependences on the e-beam parameters.

  6. Optimization of single-step tapering amplitude and energy detuning for high-gain FELs

    NASA Astrophysics Data System (ADS)

    Li, He-Ting; Jia, Qi-Ka

    2015-01-01

    We put forward a method to optimize the single-step tapering amplitude of undulator strength and initial energy tuning of electron beam to maximize the saturation power of high gain free-electron lasers (FELs), based on the physics of longitudinal electron beam phase space. Using the FEL simulation code GENESIS, we numerically demonstrate the accuracy of the estimations for parameters corresponding to the linac coherent light source and the Tesla test facility.

  7. Spontaneous rupture of the urinary bladder complicated by extensive fascitis: the importance of a high index of suspicion.

    PubMed

    Carmon, M; Nissan, A; Pappo, I; Perlberg, S; Seror, D; Haskel, Y

    1994-01-01

    Spontaneous rupture of the urinary bladder is a rare entity. This is, in part, the cause for the low rate of correct preoperative diagnosis, the high rate of delayed diagnosis, morbidity and mortality. We report a case of spontaneous rupture of the urinary bladder in an adult patient, complicated by extensive fascitis of the abdominal wall. The stormy course and long hospitalization in the case described are characteristic of patients with spontaneous bladder rupture and warrant a high index of suspicion in order to achieve an early diagnosis.

  8. Spontaneous high piezoelectricity in poly(vinylidene fluoride) nanoribbons produced by iterative thermal size reduction technique.

    PubMed

    Kanik, Mehmet; Aktas, Ozan; Sen, Huseyin Sener; Durgun, Engin; Bayindir, Mehmet

    2014-09-23

    We produced kilometer-long, endlessly parallel, spontaneously piezoelectric and thermally stable poly(vinylidene fluoride) (PVDF) micro- and nanoribbons using iterative size reduction technique based on thermal fiber drawing. Because of high stress and temperature used in thermal drawing process, we obtained spontaneously polar γ phase PVDF micro- and nanoribbons without electrical poling process. On the basis of X-ray diffraction (XRD) analysis, we observed that PVDF micro- and nanoribbons are thermally stable and conserve the polar γ phase even after being exposed to heat treatment above the melting point of PVDF. Phase transition mechanism is investigated and explained using ab initio calculations. We measured an average effective piezoelectric constant as -58.5 pm/V from a single PVDF nanoribbon using a piezo evaluation system along with an atomic force microscope. PVDF nanoribbons are promising structures for constructing devices such as highly efficient energy generators, large area pressure sensors, artificial muscle and skin, due to the unique geometry and extended lengths, high polar phase content, high thermal stability and high piezoelectric coefficient. We demonstrated two proof of principle devices for energy harvesting and sensing applications with a 60 V open circuit peak voltage and 10 μA peak short-circuit current output.

  9. Enhancing speed of pinning synchronizability: low-degree nodes with high feedback gains

    NASA Astrophysics Data System (ADS)

    Zhou, Ming-Yang; Zhuo, Zhao; Liao, Hao; Fu, Zhong-Qian; Cai, Shi-Min

    2015-12-01

    Controlling complex networks is of paramount importance in science and engineering. Despite recent efforts to improve controllability and synchronous strength, little attention has been paid to the speed of pinning synchronizability (rate of convergence in pinning control) and the corresponding pinning node selection. To address this issue, we propose a hypothesis to restrict the control cost, then build a linear matrix inequality related to the speed of pinning controllability. By solving the inequality, we obtain both the speed of pinning controllability and optimal control strength (feedback gains in pinning control) for all nodes. Interestingly, some low-degree nodes are able to achieve large feedback gains, which suggests that they have high influence on controlling system. In addition, when choosing nodes with high feedback gains as pinning nodes, the controlling speed of real systems is remarkably enhanced compared to that of traditional large-degree and large-betweenness selections. Thus, the proposed approach provides a novel way to investigate the speed of pinning controllability and can evoke other effective heuristic pinning node selections for large-scale systems.

  10. High Adherence Is Necessary to Realize Health Gains from Water Quality Interventions

    PubMed Central

    Brown, Joe; Clasen, Thomas

    2012-01-01

    Background Safe drinking water is critical for health. Household water treatment (HWT) has been recommended for improving access to potable water where existing sources are unsafe. Reports of low adherence to HWT may limit the usefulness of this approach, however. Methods and Findings We constructed a quantitative microbial risk model to predict gains in health attributable to water quality interventions based on a range of assumptions about pre-treatment water quality; treatment effectiveness in reducing bacteria, viruses, and protozoan parasites; adherence to treatment interventions; volume of water consumed per person per day; and other variables. According to mean estimates, greater than 500 DALYs may be averted per 100,000 person-years with increased access to safe water, assuming moderately poor pre-treatment water quality that is a source of risk and high treatment adherence (>90% of water consumed is treated). A decline in adherence from 100% to 90% reduces predicted health gains by up to 96%, with sharpest declines when pre-treatment water quality is of higher risk. Conclusions Results suggest that high adherence is essential in order to realize potential health gains from HWT. PMID:22586491

  11. Enhancing speed of pinning synchronizability: low-degree nodes with high feedback gains

    PubMed Central

    Zhou, Ming-Yang; Zhuo, Zhao; Liao, Hao; Fu, Zhong-Qian; Cai, Shi-Min

    2015-01-01

    Controlling complex networks is of paramount importance in science and engineering. Despite recent efforts to improve controllability and synchronous strength, little attention has been paid to the speed of pinning synchronizability (rate of convergence in pinning control) and the corresponding pinning node selection. To address this issue, we propose a hypothesis to restrict the control cost, then build a linear matrix inequality related to the speed of pinning controllability. By solving the inequality, we obtain both the speed of pinning controllability and optimal control strength (feedback gains in pinning control) for all nodes. Interestingly, some low-degree nodes are able to achieve large feedback gains, which suggests that they have high influence on controlling system. In addition, when choosing nodes with high feedback gains as pinning nodes, the controlling speed of real systems is remarkably enhanced compared to that of traditional large-degree and large-betweenness selections. Thus, the proposed approach provides a novel way to investigate the speed of pinning controllability and can evoke other effective heuristic pinning node selections for large-scale systems. PMID:26626045

  12. High gain low noise L-band preamplifier with cascade double-pass structure

    NASA Astrophysics Data System (ADS)

    Jia, Dongfang; Wang, Yanyong; Bao, Huanmin; Yang, Tianxin; Li, Shichen

    2005-06-01

    An optimized two-stage-cascade double-pass structure L-band preamplifier was proposed and experimentally studied to overcome the shortcomings of low gain coefficient and high noise figure of L-band erbium-doped fiber amplifier (EDFA). The fiber lengthes of 6.5 and 32.5 m, pump powers of 130 and 119 mW for the first and second stages respectively are used in the experiment. When input signal power is -30 dBm, the amplifier can provide gain above 38.84 dB in a wavelength range of 34 nm (1568---1602 nm), gain ripple less than 2.04 dB (40.88---38.84 dB), and noise figures lower than 5.29 dB with the lowest value of 3.95 dB at 1590 nm. Experimental and simulation results show that this low cost and high pump efficiency amplifier is suitable for the application as an L-band preamplifier in the broadband fiber communication system.

  13. High-Tc superconducting quantum interference device recordings of spontaneous brain activity: Towards high-Tc magnetoencephalography

    NASA Astrophysics Data System (ADS)

    Öisjöen, F.; Schneiderman, J. F.; Figueras, G. A.; Chukharkin, M. L.; Kalabukhov, A.; Hedström, A.; Elam, M.; Winkler, D.

    2012-03-01

    We have performed single- and two-channel high transition temperature (high-Tc) superconducting quantum interference device (SQUID) magnetoencephalography (MEG) recordings of spontaneous brain activity in two healthy human subjects. We demonstrate modulation of two well-known brain rhythms: the occipital alpha rhythm and the mu rhythm found in the motor cortex. We further show that despite higher noise-levels compared to their low-Tc counterparts, high-Tc SQUIDs can be used to detect and record physiologically relevant brain rhythms with comparable signal-to-noise ratios. These results indicate the utility of high-Tc technology in MEG recordings of a broader range of brain activity.

  14. Precision motion control with a high gain disturbance compensator for linear motors.

    PubMed

    Tan, Kok Kiong; Zhao, Shao

    2004-07-01

    In this paper, we address the problem relating to the precision control of permanent magnet linear motors to track repeated motion trajectories. A high gain disturbance compensator is developed to improve the control performance degraded due to the presence of significant disturbances. An inverse gain of the overall system model is used to set up a disturbance observer. The observed disturbance is then used to generate a "knocker" signal, to be augmented to the control signal, which can provide the additional energy necessary to overcome the effects of the disturbances. A learning scheme is used to adjust the knocker signal iteratively over the repeated cycles. Simulation and experimental results are furnished to demonstrate the effectiveness of the proposed control scheme.

  15. A bootstrapped, low-noise, and high-gain photodetector for shot noise measurement

    SciTech Connect

    Zhou, Haijun; Yang, Wenhai; Li, Zhixiu; Li, Xuefeng; Zheng, Yaohui

    2014-01-15

    We presented a low-noise, high-gain photodetector based on the bootstrap structure and the L-C (inductance and capacitance) combination. Electronic characteristics of the photodetector, including electronic noise, gain and frequency response, and dynamic range, were verified through a single-frequency Nd:YVO{sub 4} laser at 1064 nm with coherent output. The measured shot noise of 50 μW laser was 13 dB above the electronic noise at the analysis frequency of 2 MHz, and 10 dB at 3 MHz. And a maximum clearance of 28 dB at 2 MHz was achieved when 1.52 mW laser was illuminated. In addition, the photodetector showed excellent linearities for both DC and AC amplifications in the laser power range between 12.5 μW and 1.52 mW.

  16. The generation of amplified spontaneous emission in high-power CPA laser systems.

    PubMed

    Keppler, Sebastian; Sävert, Alexander; Körner, Jörg; Hornung, Marco; Liebetrau, Hartmut; Hein, Joachim; Kaluza, Malte Christoph

    2016-03-01

    An analytical model is presented describing the temporal intensity contrast determined by amplified spontaneous emission in high-intensity laser systems which are based on the principle of chirped pulse amplification. The model describes both the generation and the amplification of the amplified spontaneous emission for each type of laser amplifier. This model is applied to different solid state laser materials which can support the amplification of pulse durations ≤350 fs . The results are compared to intensity and fluence thresholds, e.g. determined by damage thresholds of a certain target material to be used in high-intensity applications. This allows determining if additional means for contrast improvement, e.g. plasma mirrors, are required for a certain type of laser system and application. Using this model, the requirements for an optimized high-contrast front-end design are derived regarding the necessary contrast improvement and the amplified "clean" output energy for a desired focussed peak intensity. Finally, the model is compared to measurements at three different high-intensity laser systems based on Ti:Sapphire and Yb:glass. These measurements show an excellent agreement with the model.

  17. Percentage of Body Fat and Weight Gain in Participants in the Tehran High School Wrestling Championship

    PubMed Central

    Kordi, Ramin; Nourian, Ruhollah; Rostami, Mohsen; Wallace, W. Angus

    2012-01-01

    Purpose Weight loss in wrestling has been found to be an interesting issue for researchers. In this regard, complications of weight loss in wrestlers before the competitions and their weight gain in course of competitions have been debated in previous studies. The objective of this study was to investigate the extent of weight gain and to estimate the percentage of body fat in participants in the Tehran high school male wrestling championship. Methods This study was a cross sectional survey. Subjects were participants of the Tehran high school male wrestling championship (n = 365). Weight gain in course of competitions and body fat levels (based on skin fold measurements) of subjects were measured. Results Between the first weigh-in of the wrestlers which was done one day before the competitions and the second weigh-in which was conducted immediately before the first round of their first competition (20 hours), 69% of subjects gained on average 1.3±0.9 kg (range: 0.1 to 6.10 kg) or 2.2±1.7% of the wrestler’s weight (range: 0.1 to 9.3). Among the subjects, the mean of fat body percentage was found to be 15.2%. Conclusions Rapid weight loss for matches was prevalent among subjects. It was also found that Iranian wrestlers have a relatively higher body fat percentage in comparison to American wrestlers. Therefore, it can be concluded that weight loss behavior of these wrestlers should be changed from using dehydration methods to using gradual methods of weight loss such as fat reduction methods. PMID:22942998

  18. Effects of bandwidth, compression speed, and gain at high frequencies on preferences for amplified music.

    PubMed

    Moore, Brian C J

    2012-09-01

    This article reviews a series of studies on the factors influencing sound quality preferences, mostly for jazz and classical music stimuli. The data were obtained using ratings of individual stimuli or using the method of paired comparisons. For normal-hearing participants, the highest ratings of sound quality were obtained when the reproduction bandwidth was wide (55 to 16000 Hz) and ripples in the frequency response were small (less than ± 5 dB). For hearing-impaired participants listening via a simulated five-channel compression hearing aid with gains set using the CAM2 fitting method, preferences for upper cutoff frequency varied across participants: Some preferred a 7.5- or 10-kHz upper cutoff frequency over a 5-kHz cutoff frequency, and some showed the opposite preference. Preferences for a higher upper cutoff frequency were associated with a shallow high-frequency slope of the audiogram. A subsequent study comparing the CAM2 and NAL-NL2 fitting methods, with gains slightly reduced for participants who were not experienced hearing aid users, showed a consistent preference for CAM2. Since the two methods differ mainly in the gain applied for frequencies above 4 kHz (CAM2 recommending higher gain than NAL-NL2), these results suggest that extending the upper cutoff frequency is beneficial. A system for reducing "overshoot" effects produced by compression gave small but significant benefits for sound quality of a percussion instrument (xylophone). For a high-input level (80 dB SPL), slow compression was preferred over fast compression.

  19. Numerical Simulation on the Spontaneous Ignition of Leaking High Pressure Hydrogen from Terminal Unit

    NASA Astrophysics Data System (ADS)

    Xiaobo, Shen; Jinhua, Sun

    The CFD simulation study was carried out on the spontaneous ignition of high pressure leaking hydrogen from some terminal units. An integrated 2D axisymmetric PDF numerical model was established. The results show that, the strong and weak discontinuous surfaces accompanied by combustion phenomenon are formed leading the local temperature and density rising up sharply. Near the outer-edge of the tube mouth, the vortexes are prone to take shape, which contribute to the mixing of hydrogen and air resulting in intenser and longer time combustion. But the combustion is not sustainable and will die out finally. The simulation catches the detailed jet structure including mach disk and barrel shock.

  20. Developing high-power hybrid resonant gain-switched thulium fiber lasers.

    PubMed

    Yan, Shuo; Wang, Yao; Zhou, Yan; Yang, Nan; Li, Yue; Tang, Yulong; Xu, Jianqiu

    2015-10-05

    In this paper, we propose hybrid-pumped resonant gain-switched thulium fiber lasers to realize high-average-power and high-pulse-energy 2-μm laser emissions. Based on numerical simulation, laser dynamics (pulse peak power, pulse energy, pulse duration, etc.) of this kind of laser system are investigated in detail. By taking advantages of the 793 nm continuous wave pump and the 1900 nm pulsed pump, performance of the laser emission can be significantly improved, with the highest average power of 28 W, peak power of 3.5 kW, pulse energy of 281 μJ, and narrowest pulse duration of 92 ns, all of which can be further optimized through designing the cavity parameters and the pumping circumstance. Compared with the pump pulses, two times improvement in pulse energy and average power has been achieved. This hybrid resonant gain-switched system has an all-fiber configuration and high efficiency (low heat load), and can be steadily extended into the cladding pump scheme, thus paving a new way to realize high power (>100 W average power) and high pulse energy (>1 mJ) 2 μm thulium fiber lasers.

  1. Fat substitutes promote weight gain in rats consuming high-fat diets

    PubMed Central

    Swithers, Susan E.; Ogden, Sean B.; Davidson, Terry L.

    2011-01-01

    The use of food products designed to mimic the sensory properties of sweet and fat while providing fewer calories has been promoted as a method for reducing food intake and body weight. However, such products may interfere with one mechanism that animals use to regulate energy balance, a learned relationship between the sensory properites of food and the caloric consequences of consuming those foods. Consistent with this hypothesis, previous data have shown that providing rats with sweet tastes that are not associated with the delivery of calories using high-intensity sweeteners results in increased food intake, body weight and adiposity, but only if the diet on which they are maintained also tastes sweet. In the present experiment, we examined whether use of the fat substitute, olestra, would have similar consequences by comparing the effects of consuming high-fat, high-calorie potato chips to the effects of consuming potato chips that sometimes signalled high calories (using high-fat potato chips) and that sometimes signalled lower calories (using non-fat potato chips manufactured with the fat substitute olestra). The results demonstrated that food intake, body weight gain and adiposity were greater for rats that consumed both the high-calorie chips and the low-calorie chips with olestra compared to rats that consumed consuming only the high-calorie chips, but only if animals were also consuming a chow diet that was high in fat and calories. When animals were maintained on a low-fat chow diet, intake, weight gain, and adiposity did not differ significantly based on chip type. However, rats previously exposed to both the low-calorie chips with olestra and the high-calorie chips exhibited increased body weight gain, food intake and adiposity when they were provided with a high fat, high calorie chow diet, even though the potato chips were no longer available. This suggests that the experience with the chips containing olestra affected the ability to predict high

  2. Effects of high CO2 levels on dynamic photosynthesis: carbon gain, mechanisms, and environmental interactions.

    PubMed

    Tomimatsu, Hajime; Tang, Yanhong

    2016-05-01

    Understanding the photosynthetic responses of terrestrial plants to environments with high levels of CO2 is essential to address the ecological effects of elevated atmospheric CO2. Most photosynthetic models used for global carbon issues are based on steady-state photosynthesis, whereby photosynthesis is measured under constant environmental conditions; however, terrestrial plant photosynthesis under natural conditions is highly dynamic, and photosynthetic rates change in response to rapid changes in environmental factors. To predict future contributions of photosynthesis to the global carbon cycle, it is necessary to understand the dynamic nature of photosynthesis in relation to high CO2 levels. In this review, we summarize the current body of knowledge on the photosynthetic response to changes in light intensity under experimentally elevated CO2 conditions. We found that short-term exposure to high CO2 enhances photosynthetic rate, reduces photosynthetic induction time, and reduces post-illumination CO2 burst, resulting in increased leaf carbon gain during dynamic photosynthesis. However, long-term exposure to high CO2 during plant growth has varying effects on dynamic photosynthesis. High levels of CO2 increase the carbon gain in photosynthetic induction in some species, but have no significant effects in other species. Some studies have shown that high CO2 levels reduce the biochemical limitation on RuBP regeneration and Rubisco activation during photosynthetic induction, whereas the effects of high levels of CO2 on stomatal conductance differ among species. Few studies have examined the influence of environmental factors on effects of high levels of CO2 on dynamic photosynthesis. We identified several knowledge gaps that should be addressed to aid future predictions of photosynthesis in high-CO2 environments.

  3. High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure.

    PubMed

    Kawada, Toru; Zheng, Can; Yanagiya, Yusuke; Uemura, Kazunori; Miyamoto, Tadayoshi; Inagaki, Masashi; Shishido, Toshiaki; Sugimachi, Masaru; Sunagawa, Kenji

    2002-03-01

    A transfer function from baroreceptor pressure input to sympathetic nerve activity (SNA) shows derivative characteristics in the frequency range below 0.8 Hz in rabbits. These derivative characteristics contribute to a quick and stable arterial pressure (AP) regulation. However, if the derivative characteristics hold up to heart rate frequency, the pulsatile pressure input will yield a markedly augmented SNA signal. Such a signal would saturate the baroreflex signal transduction, thereby disabling the baroreflex regulation of AP. We hypothesized that the transfer gain at heart rate frequency would be much smaller than that predicted from extrapolating the derivative characteristics. In anesthetized rabbits (n = 6), we estimated the neural arc transfer function in the frequency range up to 10 Hz. The transfer gain was lost at a rate of -20 dB/decade when the input frequency exceeded 0.8 Hz. A numerical simulation indicated that the high-cut characteristics above 0.8 Hz were effective to attenuate the pulsatile signal and preserve the open-loop gain when the baroreflex dynamic range was finite.

  4. High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection

    PubMed Central

    Sun, Raphael C.; Choi, Pamela M.; Diaz-Miron, Jose; Sommovilla, Joshua; Guo, Jun; Erwin, Christopher R.

    2016-01-01

    Introduction Short bowel syndrome (SBS) is a morbid clinical condition that results from massive small-bowel resection (SBR). After SBR, there is a dramatic weight loss in the acute postoperative period. Our aim was to determine the impact of a high-protein diet (HPD) on weight gain and body composition in mice after SBR. Methods C57BL/6 mice underwent 50 % proximal SBR. Postoperatively, mice were randomly selected to receive standard rodent liquid diet (LD) (n=6) or an isocaloric HPD (n=9) for 28 days. Mice weights were recorded daily. Body composition analyses were obtained weekly. Student's t test was used for statistical comparisons with p<0.05 considered significant. Results Mice that were fed HPD after SBR returned to baseline weight on average at postoperative day (POD) 8 versus mice that were fed LD that returned to baseline weight on average at POD 22. Total fat mass and lean mass were significantly greater by POD 14 within the HPD group. Both groups of mice demonstrated normal structural adaptation. Conclusion HPD results in greater weight gain and improved body composition in mice after SBR. This finding may be clinically important for patients with SBS since improved weight gain may reduce the time needed for parenteral nutrition. PMID:25519080

  5. High-gain optical Cherenkov oscillator driven by low-voltage electron beam

    SciTech Connect

    Smetanin, I.V.; Oraevsky, A.N.

    1995-12-31

    A novel scheme of high-gain optical (from IR up to UV) Cherenkov-type oscillator driven by low-voltage high-current electron beam is proposed in the present report. In the scheme discussed the magnetized electron beam propagates above the surface of absorbing medium of complex dielectric susceptibility {epsilon}{omega} = {epsilon}{sub 1}({omega}) + i{epsilon}{sub 2}({omega}), {epsilon}{sub 2}>0. We have found that at frequencies {omega} that {beta}{sup 2}> 2{epsilon}{sub 1}/{vert_bar}{epsilon}{vert_bar}{sup 2} ({beta} = v/c, v is the electron velocity), an amplification of co-propagating slow surface electromagnetic wave is possible. In contrast to the conventional Cherenkov oscillators, the absorption condition {epsilon}2>0 is crucial for the gain, which is absent for transparent medium. The physics of this amplification effect is analogous to that of electron beam dissipative instability. The wavelength generated is determined here by dielectric properties of the surface, and does not depend strongly on electron energy. Thus it is possible to use rather compact low voltage ({le} 1MeV) high-current accelerators as drivers. Optimum oscillation conditions are found to be at frequencies near the resonance absorption lines of surface material (i.e. from IR up to UV). The gain up to {approximately}0.5cm{sup -1} in the near IR ({approximately}10THz, SrF{sub 2} absorption line) is possible for 250keV high current (density {approximately}10{sup 12}cm{sup -3}) electron beam.

  6. Oscillator Seeding of a High Gain Harmonic Generation FEL in a Radiator-First Configuration

    SciTech Connect

    Gandhi, P.; Wurtele, J.; Penn, G.; Reinsch, M.

    2012-05-20

    A longitudinally coherent X-ray pulse from a high repetition rate free electron laser (FEL) is desired for a wide variety of experimental applications. However, generating such a pulse with a repetition rate greater than 1 MHz is a significant challenge. The desired high repetition rate sources, primarily high harmonic generation with intense lasers in gases or plasmas, do not exist now, and, for the multi-MHz bunch trains that superconducting accelerators can potentially produce, are likely not feasible with current technology. In this paper, we propose to place an oscillator downstream of a radiator. The oscillator generates radiation that is used as a seed for a high gain harmonic generation (HGHG) FEL which is upstream of the oscillator. For the first few pulses the oscillator builds up power and, until power is built up, the radiator has no HGHG seed. As power in the oscillator saturates, the HGHG is seeded and power is produced. The dynamics and stability of this radiator-first scheme is explored analytically and numerically. A single-pass map is derived using a semi-analytic model for FEL gain and saturation. Iteration of the map is shown to be in good agreement with simulations. A numerical example is presented for a soft X-ray FEL.

  7. Nanoparticle-assisted high photoconductive gain in composites of polymer and fullerene.

    PubMed

    Chen, Hsiang-Yu; Lo, Michael K F; Yang, Guanwen; Monbouquette, Harold G; Yang, Yang

    2008-09-01

    Polymer-inorganic nanocrystal composites offer an attractive means to combine the merits of organic and inorganic materials into novel electronic and photonic systems. However, many applications of these composites are limited by the solubility and distribution of the nanocrystals in the polymer matrices. Here we show that blending CdTe nanoparticles into a polymer-fullerene matrix followed by solvent annealing can achieve high photoconductive gain under low applied voltages. The surface capping ligand renders the nanoparticles highly soluble in the polymer blend, thereby enabling high CdTe loadings. An external quantum efficiency as high as approximately 8,000% at 350 nm was achieved at -4.5 V. Hole-dominant devices coupled with atomic force microscopy images show a higher concentration of nanoparticles near the cathode-polymer interface. The nanoparticles and trapped electrons assist hole injection into the polymer under reverse bias, contributing to efficiency values in excess of 100%.

  8. Highly accurate measurements of the spontaneous fission half-life of 240,242Pu

    NASA Astrophysics Data System (ADS)

    Salvador-Castiñeira, P.; Bryś, T.; Eykens, R.; Hambsch, F.-J.; Moens, A.; Oberstedt, S.; Sibbens, G.; Vanleeuw, D.; Vidali, M.; Pretel, C.

    2013-12-01

    Fast spectrum neutron-induced fission cross-section data for transuranic isotopes are of special demand from the nuclear data community. In particular highly accurate data are needed for the new generation IV nuclear applications. The aim is to obtain precise neutron-induced fission cross sections for 240Pu and 242Pu. To do so, accurate data on spontaneous fission half-lives must be available. Also, minimizing uncertainties in the detector efficiency is a key point. We studied both isotopes by means of a twin Frisch-grid ionization chamber with the goal of improving the present data on the neutron-induced fission cross section. For the two plutonium isotopes the high α-particle decay rates pose a particular problem to experiments due to piling-up events in the counting gas. Argon methane and methane were employed as counting gases, the latter showed considerable improvement in signal generation due to its higher drift velocity. The detection efficiency for both samples was determined, and improved spontaneous fission half-lives were obtained with very low statistical uncertainty (0.13% for 240Pu and 0.04% for 242Pu): for 240Pu, T1/2,SF=1.165×1011 yr (1.1%), and for 242Pu, T1/2,SF=6.74×1010 yr (1.3%). Systematic uncertainties are due to sample mass (0.4% for 240Pu and 0.9% for 242Pu) and efficiency (1%).

  9. Spontaneous high-yield hydrogen production from cellulosic materials and water catalyzed by enzyme cocktail

    SciTech Connect

    Ye, Xinhao; Wang, Yiran; Hopkins, Robert C.; Adams, Michael W. W.; Evans, Barbara R; Mielenz, Jonathan R; Zhang, Y.-H. Percival

    2009-01-01

    Carbon-neutral hydrogen gas is a compelling energy carrier, especially for the transportation section. Low-cost hydrogen can be produced from abundant renewable lignocellulosic biomass through a number of methods employing chemical catalysis, biocatalysis or a combination of both, but these technologies suffer from low hydrogen yields (well below the theoretical yield of 12 H2 per glucose), undesired side-products and/or required severe reaction conditions. Here we present a novel in vitro synthetic biology approach for producing near theoretical hydrogen yields from cellulosic materials (cellodextrins) and water at 32oC and 1 atm. These non-natural catabolic pathways containing up to 14 enzymes and one coenzyme degrade cellodextrins initially to glucose-1-phosphate and eventually to CO2, split water and finally release the chemical energy in the form of hydrogen gas. Up to 11.2 H2 per anhydroglucose was produced in a batch reaction. This spontaneous endothermic reaction is driven by entropy gain, suggesting that the thermal energy is adsorbed for generating more chemical energy (hydrogen gas) than that in cellodextrins, i.e., output/input of chemical energy > 1, with an input of ambient-temperature thermal energy.

  10. Method and system for modulation of gain suppression in high average power laser systems

    DOEpatents

    Bayramian, Andrew James [Manteca, CA

    2012-07-31

    A high average power laser system with modulated gain suppression includes an input aperture associated with a first laser beam extraction path and an output aperture associated with the first laser beam extraction path. The system also includes a pinhole creation laser having an optical output directed along a pinhole creation path and an absorbing material positioned along both the first laser beam extraction path and the pinhole creation path. The system further includes a mechanism operable to translate the absorbing material in a direction crossing the first laser beam extraction laser path and a controller operable to modulate the second laser beam.

  11. Analysis of FEL-based CeC amplification at high gain limit

    SciTech Connect

    Wang, G.; Litvinenko, V.; Jing, Y.

    2015-05-03

    An analysis of Coherent electron Cooling (CeC) amplifier based on 1D Free Electron Laser (FEL) theory was previously performed with exact solution of the dispersion relation, assuming electrons having Lorentzian energy distribution. At high gain limit, the asymptotic behavior of the FEL amplifier can be better understood by Taylor expanding the exact solution of the dispersion relation with respect to the detuning parameter. In this work, we make quadratic expansion of the dispersion relation for Lorentzian energy distribution and investigate how longitudinal space charge and electrons’ energy spread affect the FEL amplification process.

  12. Sub-Poissonian shot noise of a high internal gain injection photon detector.

    PubMed

    Memis, Omer Gokalp; Katsnelson, Alex; Kong, Soon-Cheol; Mohseni, Hooman; Yan, Minjun; Zhang, Shuang; Hossain, Tim; Jin, Niu; Adesida, Ilesanmi

    2008-08-18

    The noise performance of an infrared injection photon detector with very high internal gain was investigated at a wavelength of 1.55 mum. The devices showed sub-Poissonian shot noise with Fano factors around 0.55 at 0.7 V at room temperature. Optical to electrical conversion factors of 3000 electrons per absorbed photon were recorded at 0.7 V. The change in noise-equivalent power with respect to bias voltage was evaluated. The optical to electrical conversion factor and Fano factor were measured under increasing illumination and compared to theoretical expectations.

  13. High-accuracy picosecond characterization of gain-switched laser diodes

    SciTech Connect

    Cova, S.; Lacaita, A.; Ghioni, M.; Ripamonti, G. )

    1989-12-15

    A unique combination of the time-correlated photon-counting technique and single-photon avalanche diode detectors gives an accurate characterization of gain-switched semiconductor lasers with picosecond resolution. The high sensitivity and the clean shape of the time response reveal even small features (reflections and relaxation oscillations), making a true optimization of the laser-diode operation possible. The technique outperforms the standard characterization with ultrafast p-i-n photodiodes and a sampling oscilloscope. In addition, compared with other methods, it has favorable features that greatly simplify the measurement.

  14. ONT High Gain Initiative WRAP (Wide Area Rapid Acoustic Prediction) computational performance section

    SciTech Connect

    McGraw, J.R.; Hedstrom, G.; De Groot, T.

    1990-10-02

    LLNL received a contract during March 1990 to perform three tasks for ONT. This letter report covers Task I which concerned a supercomputing effort in a program termed the High Gain Initiative, which is an anti-submarine (ASW) project that requires substantial computational and signal processing expertise. The core of the computational aspects at the present time is a code called WRAP (Wide Area Rapid Acoustic Prediction). LLNL's objective was to study the WRAP model and determine the feasibility and limits of its optimization. At the present time, the WRAP code runs on a single processor VAX computer.

  15. High Gain Antenna System Deployment Mechanism Integration, Characterization, and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Parong, Fil; Russell, Blair; Garcen, Walter; Rose, Chris; Johnson, Chris; Huber, Craig

    2014-01-01

    The integration and deployment testing of the High Gain Antenna System (HGAS) for the Global Precipitation Measurement mission is summarized. The HGAS deployment mechanism is described. The gravity negation system configuration and its influence on vertical, ground-based deployment tests are presented with test data and model predictions. A focus is made on the late discovery and resolution of a potentially mission-degrading deployment interference condition. The interaction of the flight deployment mechanism, gravity-negation mechanism, and use of dynamic modeling is described and lessons learned presented

  16. High Gain Antenna System Deployment Mechanism Integration, Characterization, and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Parong, Fil; Russell, Blair; Garcen, Walter; Rose, Chris; Johnson, Chris; Huber, Craig

    2014-01-01

    The integration and deployment testing of the High Gain Antenna System for the Global Precipitation Measurement mission is summarized. The HGAS deployment mechanism is described. The gravity negation system configuration and its influence on vertical, ground-based, deployment tests are presented with test data and model predictions. A focus is made on the late discovery and resolution of a potentially mission degrading deployment interference condition. The interaction of the flight deployment mechanism, gravity negation mechanism, and use of dynamic modeling is described and lessons learned presented.

  17. High gain FEL amplification of charge modulation caused by a hadron

    SciTech Connect

    Litvinenko,V.; Ben-Zvi, I.; Hao, Y.; Kayran, D.; Pozdeyev, E.; Wang, G.; Reiche, S.; Shevchenko, O.; Vinokurov, N. A.

    2008-08-24

    In scheme of coherent electron cooling (CeC) [1,2], a modulation of electron beam density induced by a copropagation hadron is amplified in high gain FEL. The resulting amplified modulation of electron beam, its shape, form and its lethargy determine number of important properties of the coherent electron cooling. In this talk we present both analytical and numerical (using codes RON [3] and Genesis [4]) evaluations of the corresponding Green functions. We also discuss influence of electron beam parameters on the FEL response.

  18. High-dimensional atom localization via spontaneously generated coherence in a microwave-driven atomic system.

    PubMed

    Wang, Zhiping; Chen, Jinyu; Yu, Benli

    2017-02-20

    We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to the space-dependent atom-field interaction, it is found that the detecting probability and precision of 2D and 3D atom localization behaviors can be significantly improved via adjusting the system parameters, the phase, amplitude, and initial population distribution. Interestingly, the atom can be localized in volumes that are substantially smaller than a cubic optical wavelength. Our scheme opens a promising way to achieve high-precision and high-efficiency atom localization, which provides some potential applications in high-dimensional atom nanolithography.

  19. Enhancing the performance of a high-gain free electron laser operating at millimeter wavelengths

    SciTech Connect

    Barletta, W.A.; Anderson, B.; Fawley, W.M.; Neil, V.K.; Orzechowski, T.J.; Prosnitz, D.; Scharlemann, E.T.; Yarema, S.M.; Paul, A.C.; Hopkins, D.

    1984-10-25

    A high-gain, high extraction efficiency, free electron laser (FEL) amplifier operating at the Experimental Test Accelerator (ETA) at 34.6 GHz has demonstrated a small signal gain of 13.4 dB/m. With a 30 kW input signal, the amplifier has produced a saturated output of 80 MW and a 5% extraction efficiency. Comparison of these results with a linear model at small signal levels indicates that the amplifier can deliver saturated output starting from noise, if the brightness of the electron beam is sufficiently high. The brightness of the ETA is far below that possible with optimized choice of practical design characteristics such as peak voltage, cathode type, gun electrode geometry, and focusing field topology. In particular, the measured brightness of the ETA injector is limited by plasma effects from the present cold, plasma cathode. As part of a coordinated theoretical and experimental effort to improve injector performance, we are using the EBQ gun design code to explore the current limits of gridless, relativistic, Pierce columns with moderate current density (>50 A/cm/sup 2/) at the cathode. The chief component in our experimental effort is a readily modified electron gun that will allow us to test many candidate cathode materials, types, and electrode geometries at field stresses up to 1 MV/cm. 8 references, 5 figures.

  20. Ground penetrating radar enabled by high gain GaAs photoconductive semiconductor switches

    SciTech Connect

    Loubriel, G.M.; Buttram, M.T.; Aurand, J.F.; Zutavern, F.J.

    1996-06-01

    The ability of high gain GaAs Photoconductive Semiconductor switches (PCSS) to deliver fast risetime, low jitter pulses when triggered with small laser diode arrays makes them suitable for their use in ultrawide bandwidth (UWB), impulse transmitters. This paper will summarize the state-of-the-art in high gain GaAs switches and discuss how GaAs switches are being implemented in a transmitter for detection of underground structures. The advantage of this type of semiconductor switch is demonstrated operation at high voltages (100 kV) and repetition rates (1 kHz) with the potential for much higher repetition rates. The latter would increase the demonstrated average powers of 100 W to 1 kW and higher. We will also present an analysis of the effectiveness of different pulser geometries that result in transmitted pulses with varying frequency content. To this end, we have developed a simple model that includes transmit and receive antenna response, attenuation and dispersion of the electromagnetic impulses by the soil, and target cross sections.

  1. High perceptual load leads to both reduced gain and broader orientation tuning

    PubMed Central

    Stolte, Moritz; Bahrami, Bahador; Lavie, Nilli

    2014-01-01

    Due to its limited capacity, visual perception depends on the allocation of attention. The resultant phenomena of inattentional blindness, accompanied by reduced sensory visual cortex response to unattended stimuli in conditions of high perceptual load in the attended task, are now well established (Lavie, 2005; Lavie, 2010, for reviews). However, the underlying mechanisms for these effects remain to be elucidated. Specifically, is reduced perceptual processing under high perceptual load a result of reduced sensory signal gain, broader tuning, or both? We examined this question with psychophysical measures of orientation tuning under different levels of perceptual load in the task performed. Our results show that increased perceptual load leads to both reduced sensory signal and broadening of tuning. These results clarify the effects of attention on elementary visual perception and suggest that high perceptual load is critical for attentional effects on sensory tuning. PMID:24610952

  2. Subthreshold Schottky-barrier thin-film transistors with ultralow power and high intrinsic gain

    NASA Astrophysics Data System (ADS)

    Lee, Sungsik; Nathan, Arokia

    2016-10-01

    The quest for low power becomes highly compelling in newly emerging application areas related to wearable devices in the Internet of Things. Here, we report on a Schottky-barrier indium-gallium-zinc-oxide thin-film transistor operating in the deep subthreshold regime (i.e., near the OFF state) at low supply voltages (<1 volt) and ultralow power (<1 nanowatt). By using a Schottky-barrier at the source and drain contacts, the current-voltage characteristics of the transistor were virtually channel-length independent with an infinite output resistance. It exhibited high intrinsic gain (>400) that was both bias and geometry independent. The transistor reported here is useful for sensor interface circuits in wearable devices where high current sensitivity and ultralow power are vital for battery-less operation.

  3. Hippocampal NMDA receptors are involved in rats' spontaneous object recognition only under high memory load condition.

    PubMed

    Sugita, Manami; Yamada, Kazuo; Iguchi, Natsumi; Ichitani, Yukio

    2015-10-22

    The possible involvement of hippocampal N-methyl-D-aspartate (NMDA) receptors in spontaneous object recognition was investigated in rats under different memory load conditions. We first estimated rats' object memory span using 3-5 objects in "Different Objects Task (DOT)" in order to confirm the highest memory load condition in object recognition memory. Rats were allowed to explore a field in which 3 (3-DOT), 4 (4-DOT), or 5 (5-DOT) different objects were presented. After a delay period, they were placed again in the same field in which one of the sample objects was replaced by another object, and their object exploration behavior was analyzed. Rats could differentiate the novel object from the familiar ones in 3-DOT and 4-DOT but not in 5-DOT, suggesting that rats' object memory span was about 4. Then, we examined the effects of hippocampal AP5 infusion on performance in both 2-DOT (2 different objects were used) and 4-DOT. The drug treatment before the sample phase impaired performance only in 4-DOT. These results suggest that hippocampal NMDA receptors play a critical role in spontaneous object recognition only when the memory load is high.

  4. Polarization beam combination technique for gain saturation effect compensation in high-energy systems

    NASA Astrophysics Data System (ADS)

    Chen, Junchi; Peng, Yujie; Su, Hongpeng; Leng, Yuxin

    2016-06-01

    To compensate for the gain saturation effect in the high-energy laser amplifier, a modified polarization beam combination (PBC) method is introduced to reshape temporal waveform of the injected laser pulse to obtain a controlled high-energy laser pulse shape after amplification. One linearly polarized beam is divided into two orthogonal polarized beams, which spatially recombine together collinearly after propagating different optical paths with relative time delay in PBC structure. The obtained beam with polarization direction being rotated by the following half wave plate is divided and combined again to reform a new beam in another modified polarization beam structure. The reformed beam is injected into three cascaded laser amplifiers. The amplified pulse shape can be controlled by the incident pulse shape and amplifier gain, which is agreeable to the simulation by the Frank-Nodvik equations. Based on the simple method, the various temporal waveform of output pulse with tunable 7 to 20 ns pulse duration can be obtained without interferometric fringes.

  5. Longevity improvement of optically activated, high gain GaAs photoconductive semiconductor switches

    SciTech Connect

    MAR,ALAN; LOUBRIEL,GUILLERMO M.; ZUTAVERN,FRED J.; O'MALLEY,MARTIN W.; HELGESON,WESLEY D.; BROWN,DARWIN JAMES; HJALMARSON,HAROLD P.; BACA,ALBERT G.

    2000-03-02

    The longevity of high gain GaAs photoconductive semiconductor switches (PCSS) has been extended to over 100 million pulses at 23A, and over 100 pulses at 1kA. This is achieved by improving the ohmic contacts by doping the semi-insulating GaAs underneath the metal, and by achieving a more uniform distribution of contact wear across the entire switch by distributing the trigger light to form multiple filaments. This paper will compare various approaches to doping the contacts, including ion implantation, thermal diffusion, and epitaxial growth. The device characterization also includes examination of the filament behavior using open-shutter, infra-red imaging during high gain switching. These techniques provide information on the filament carrier densities as well as the influence that the different contact structures and trigger light distributions have on the distribution of the current in the devices. This information is guiding the continuing refinement of contact structures and geometries for further improvements in switch longevity.

  6. High gain 1.3-μm GaInNAs SOA with fast gain dynamics and enhanced temperature stability

    NASA Astrophysics Data System (ADS)

    Fitsios, D.; Giannoulis, G.; Iliadis, N.; Korpijärvi, V.-M.; Viheriälä, J.; Laakso, A.; Dris, S.; Spyropoulou, M.; Avramopoulos, H.; Kanellos, G. T.; Pleros, N.; Guina, M.

    2014-03-01

    Semiconductor optical amplifiers (SOAs) are a well-established solution of optical access networks. They could prove an enabling technology for DataCom by offering extended range of active optical functionalities. However, in such costand energy-critical applications, high-integration densities increase the operational temperatures and require powerhungry external cooling. Taking a step further towards improving the cost and energy effectiveness of active optical components, we report on the development of a GaInNAs/GaAs (dilute nitride) SOA operating at 1.3μm that exhibits a gain value of 28 dB and combined with excellent temperature stability owing to the large conduction band offset between GaInNAs quantum well and GaAs barrier. Moreover, the characterization results reveal almost no gain variation around the 1320 nm region for a temperature range from 20° to 50° C. The gain recovery time attained values as short as 100 ps, allowing implementation of various signal processing functionalities at 10 Gb/s. The combined parameters are very attractive for application in photonic integrated circuits requiring uncooled operation and thus minimizing power consumption. Moreover, as a result of the insensitivity to heating issues, a higher number of active elements can be integrated on chip-scale circuitry, allowing for higher integration densities and more complex optical on-chip functions. Such component could prove essential for next generation DataCom networks.

  7. Redesign of a Variable-Gain Output Feedback Longitudinal Controller Flown on the High-Alpha Research Vehicle (HARV)

    NASA Technical Reports Server (NTRS)

    Ostroff, Aaron J.

    1998-01-01

    This paper describes a redesigned longitudinal controller that flew on the High-Alpha Research Vehicle (HARV) during calendar years (CY) 1995 and 1996. Linear models are developed for both the modified controller and a baseline controller that was flown in CY 1994. The modified controller was developed with three gain sets for flight evaluation, and several linear analysis results are shown comparing the gain sets. A Neal-Smith flying qualities analysis shows that performance for the low- and medium-gain sets is near the level 1 boundary, depending upon the bandwidth assumed, whereas the high-gain set indicates a sensitivity problem. A newly developed high-alpha Bode envelope criterion indicates that the control system gains may be slightly high, even for the low-gain set. A large motion-base simulator in the United Kingdom was used to evaluate the various controllers. Desired performance, which appeared to be satisfactory for flight, was generally met with both the low- and medium-gain sets. Both the high-gain set and the baseline controller were very sensitive, and it was easy to generate pilot-induced oscillation (PIO) in some of the target-tracking maneuvers. Flight target-tracking results varied from level 1 to level 3 and from no sensitivity to PIO. These results were related to pilot technique and whether actuator rate saturation was encountered.

  8. Theoretical study of the design and performance of a high-gain, high-extraction-efficiency FEL oscillator

    SciTech Connect

    Goldstein, J.; Nguyen, D.C.; Sheffield, R.L.

    1996-10-01

    We present the results of theoretical and simulation studies of the design and performance of a new F type of FEL oscillator. This device, known by the acronym RAFEL for Regenerative Amplifier Free-Electron Laser, will be constructed in the space presently occupied by the AFEL (Advanced FEL) at Los Alamos, and will be driven by an upgraded (to higher average power) version of the present AFEL linac. In order to achieve a long-time-averaged optical output power of {approximately} 1 kW using an electron beam with an average power of {approximately} 20 kW, a rather high extraction efficiency {eta} {approximately} 5% is required. We have designed a 2-m-long undulator to attain this goal: the first meter is untapered and provides high gain while the second meter is linearly-tapered in magnetic field amplitude to provide high extraction efficiency in the standard K-M-R manner. Two-plane focusing and linear polarization of the undulator are assumed. Electron-beam properties from PARMEIA simulations of the AFEL accelerator were used in the design. A large saturated gain, {approximately} 500, requires a very small optical feedback to keep the device operating at steady-state. However, the large gain leads to distorted optical modes which require two- and three-dimensional simulations to adequately treat diffraction effects. This FEL will be driven by 17 MeV electrons and will operate in the 16 {mu}m spectral region.

  9. A Jitter-Mitigating High Gain Antenna Pointing Algorithm for the Solar Dynamics Observatory

    NASA Technical Reports Server (NTRS)

    Bourkland, Kristin L.; Liu, Kuo-Chia; Blaurock, Carl

    2007-01-01

    This paper details a High Gain Antenna (HGA) pointing algorithm which mitigates jitter during the motion of the antennas on the Solar Dynamics Observatory (SDO) spacecraft. SDO has two HGAs which point towards the Earth and send data to a ground station at a high rate. These antennas are required to track the ground station during the spacecraft Inertial and Science modes, which include periods of inertial Sunpointing as well as calibration slews. The HGAs also experience handoff seasons, where the antennas trade off between pointing at the ground station and pointing away from the Earth. The science instruments on SDO require fine Sun pointing and have a very low jitter tolerance. Analysis showed that the nominal tracking and slewing motions of the antennas cause enough jitter to exceed the HGA portion of the jitter budget. The HGA pointing control algorithm was expanded from its original form as a means to mitigate the jitter.

  10. Millimeter-wave double-dipole antennas for high-gain integrated reflector illumination

    NASA Astrophysics Data System (ADS)

    Filipovic, Daniel F.; Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.

    1992-05-01

    A double-dipole antenna backed by a ground plane has been fabricated for submillimeter wavelengths. The double-dipole antenna is integrated on a thin dielectric membrane with a planar detector at its center. Measured feed patterns at 246 GHz agree well with theory and demonstrate a rotationally symmetric pattern with high coupling efficiency to Gaussian beams. The input impedance is around 50 ohms, and will match well to a Schottky diode or SIS detector. The double-dipole antenna served as the feed for a small machined parabolic reflector. The integrated reflector had a measured gain of 37 dB at 119 microns. This makes the double-dipole antenna ideally suited as a feed for high resolution tracking or for long focal length Cassegrain antenna systems.

  11. A comparative study of the spontaneous social interactions of children with high-functioning autism and children with Asperger's disorder.

    PubMed

    Macintosh, Kathleen; Dissanayake, Cheryl

    2006-03-01

    A comparative observational study was undertaken of the spontaneous social interactions of children with high-functioning autism and Asperger's disorder. The sample comprised 20 children with high-functioning autism, 19 children with Asperger's disorder and 17 typically developing children matched on chronological age and overall mental age. A one-zero time sampling technique was used in live coding of the children's spontaneous social and play behaviours in the schoolyard. Few differences were found between children with high-functioning autism and Asperger's disorder on the dimensions of social interaction investigated. In contrast, the social behaviour of both clinical samples often deviated markedly from that of the typically developing children. The findings confirmed that although children with high-functioning autism or Asperger's disorder are often socially isolated relative to their typically developing peers, they are capable of spontaneously engaging socially with other children. The results were supportive of the hypothesis that Asperger's disorder is on a continuum with autistic disorder.

  12. Progress in laboratory high gain ICF (inertial confinement fusion): Prospects for the future

    SciTech Connect

    Storm, E.; Lindl, J.D.; Campbell, E.M.; Bernat, T.P.; Coleman, L.W.; Emmett, J.L.; Hogan, W.J.; Hunt, J.T.; Krupke, W.F.; Lowdermilk, W.H.

    1988-01-01

    Inertial confinement fusion (ICF), a thermonuclear reaction in a small (/approximately/5 mm diameter) fuel capsule filled with a few milligrams of deuterium and tritium, has been the subject of very fruitful experimentation since the early 1970's. High gain ICF is now on the threshold of practical applications. With a Laboratory Microfusion Facility (LMF), these applications will have major implications for national defense, basic and applied science, and power production. With a driver capable of delivering about 10 MJ in a 10-ns pulse at an intensity of /approximately/3 /times/ 10/sup 14/ W/cm/sup 2/, an appropriately configured cryogenic capsule could be compressed to a density of about 200 g/cm/sup 3/ and a temperature of 3--5 keV. Under these conditions, up to 10 mg of DT could be ignited, and with a burn efficiency of about 30%, release up to 1000 MJ of fusion energy, an energy gain of about 100. A thousand megajoules is equivalent to about one quarter ton of TNT, or about 7 gallons of oil--an amount of energy tractable under laboratory conditions and potentially very useful for a variety of applications. 61 refs., 33 figs.

  13. Effects of undulator interruptions on the performance of high-gain FEL amplifiers

    SciTech Connect

    Kim, K.J.; Xie, M.; Pelligrini, C.

    1995-12-31

    The high-gain amplifiers for short wavelength free electron lasers (FELs) such as the LCLS project require a long undulator. The construction of the undulator as well as the FEL operation would become easier if the undulator could be interrupted with drift sections every few gain lengths. We have investigated the influence of such interruption on the FEL performances. Three effects are considered: (i) the diffraction loss, (ii) the phase mismatch and, (iii) the phase smearing due to velocity spread and to dispersion errors. The effect (i) is the loss during the process in which the optical mode in a section of the undulator leaves the undulator, propagates through the free space and then re-enters and re-adjusts in the next section. The effect (ii) is the fact that the phase of the optical beam is displaced with respect to the electrons density modulation for optical FEL interaction due to the slippage of the electron beam in the interruption region. The effect (iii) is the fact that electrons velocity spread, emittance, and dispersion due to misalignment of the quadrupoles used for additional focusing lead to a reduction of the bunching factor. We present an approximate analysis of these effects. When applied to the LCLS parameters, we find that the effect (i) is negligible, the effect (ii) gives a condition on the length of the drift section, and the effects (iii) are small, but could be non-negligible if there are sufficient number of interruptions.

  14. Spontaneous Raman Scattering (SRS) System for Calibrating High-Pressure Flames Became Operational

    NASA Technical Reports Server (NTRS)

    Nguyen, Quang-Viet

    2003-01-01

    A high-performance spontaneous Raman scattering (SRS) system for measuring quantitative species concentration and temperature in high-pressure flames is now operational. The system is located in Glenn s Engine Research Building. Raman scattering is perhaps the only optical diagnostic technique that permits the simultaneous (single-shot) measurement of all major species (N2, O2, CO2, H2O, CO, H2, and CH4) as well as temperature in combustion systems. The preliminary data acquired with this new system in a 20-atm hydrogen-air (H2-air) flame show excellent spectral coverage, good resolution, and a signal-to-noise ratio high enough for the data to serve as a calibration standard. This new SRS diagnostic system is used in conjunction with the newly developed High- Pressure Gaseous Burner facility (ref. 1). The main purpose of this diagnostic system and the High-Pressure Gaseous Burner facility is to acquire and establish a comprehensive Raman-scattering spectral database calibration standard for the combustion diagnostic community. A secondary purpose of the system is to provide actual measurements in standardized flames to validate computational combustion models. The High-Pressure Gaseous Burner facility and its associated SRS system will provide researchers throughout the world with new insights into flame conditions that simulate the environment inside the ultra-high-pressure-ratio combustion chambers of tomorrow s advanced aircraft engines.

  15. Design of a high-power, high-gain, 2nd harmonic, 22.848 GHz gyroklystron

    SciTech Connect

    Veale, M.; Purohit, P.; Lawson, W.

    2013-08-15

    In this paper we consider the design of a four-cavity, high-gain K-band gyroklystron experiment for high gradient structure testing. The frequency doubling gyroklystron utilizes a beam voltage of 500 kV and a beam current of 200 A from a magnetron injection gun (MIG) originally designed for a lower-frequency device. The microwave circuit features input and gain cavities in the circular TE{sub 011} mode and penultimate and output cavities that operate at the second harmonic in the TE{sub 021} mode. We investigate the MIG performance and study the behavior of the circuit for different values of perpendicular to parallel velocity ratio (α= V{sub ⊥}/ V{sub z}). This microwave tube is expected to be able to produce at least 20 MW of power in 1μs pulses at a repetition rate of at least 120 Hz. A maximum efficiency of 26% and a large signal gain of 58 dB under zero-drive stable conditions were simulated for a velocity ratio equal to 1.35.

  16. Highly pH-responsive sensor based on amplified spontaneous emission coupled to colorimetry

    PubMed Central

    Zhang, Qi; Castro Smirnov, Jose R.; Xia, Ruidong; Pedrosa, Jose M.; Rodriguez, Isabel; Cabanillas-Gonzalez, Juan; Huang, Wei

    2017-01-01

    We demonstrated a simple, directly-readable approach for high resolution pH sensing. The method was based on sharp changes in Amplified Spontaneous Emission (ASE) of a Stilbene 420 (ST) laser dye triggered by the pH-dependent absorption of Bromocresol Green (BG). The ASE threshold of BG:ST solution mixtures exhibited a strong dependence on BG absorption, which was drastically changed by the variations of the pH of BG solution. As a result, ASE on-off or off-on was observed with different pH levels achieved by ammonia doping. By changing the concentration of the BG solution and the BG:ST blend ratio, this approach allowed to detect pH changes with a sensitivity down to 0.05 in the 10–11 pH range. PMID:28387354

  17. High performance quantum cascade lasers: Loss, beam stability, and gain engineering

    NASA Astrophysics Data System (ADS)

    Bouzi, Pierre Michel

    Quantum Cascade (QC) lasers are semiconductor devices emitting in the mid-infrared (3-30 micron) and terahertz (30-300 micron) regions of the electromagnetic spectrum. Since their first demonstration by Jerome Faist et. al. in 1994, they have evolved very quickly into high performance devices and given rise to many applications such as trace-gas sensing, medical diagnosis, free-space communication, and light detection and ranging (LIDAR). In this thesis, we investigate a further increase of the performance of QC devices and, through meticulous device modeling and characterizations, gain a deeper understanding of several of their unique characteristics, especially their carrier transport and lifetime, their characteristic temperature, their waveguide loss and modal gain, their leakage current, and their transverse mode profile. First, in our quest to achieve higher performance, we investigate the effect of growth asymmetries on device transport characteristics. This investigation stems from recent studies on the role of interface roughness on intersubband scattering and device performance. Through a symmetric active core design, we find that interface roughness and ionized impurity scattering induced by dopant migration play a significant role in carrier transport through the device. Understanding how interface roughness affects intersubband scattering, in turn, we engineer the gain in QC devices by placing monolayer barriers at specific locations within the device band structure. These strategically placed additional thin barrier layers introduce roughness scattering into the device active region, thereby selectively decreasing the lower laser state lifetime and increasing population inversion necessary for laser action. Preliminary measurement results from modified devices reveal a 50% decrease in the emission broadening compared to the control structures, which should lead to a two-fold increase in gain. A special class of so-called "strong coupling" QC lasers

  18. Calibration of Gimbaled Platforms: The Solar Dynamics Observatory High Gain Antennas

    NASA Technical Reports Server (NTRS)

    Hashmall, Joseph A.

    2006-01-01

    Simple parameterization of gimbaled platform pointing produces a complete set of 13 calibration parameters-9 misalignment angles, 2 scale factors and 2 biases. By modifying the parameter representation, redundancy can be eliminated and a minimum set of 9 independent parameters defined. These consist of 5 misalignment angles, 2 scale factors, and 2 biases. Of these, only 4 misalignment angles and 2 biases are significant for the Solar Dynamics Observatory (SDO) High Gain Antennas (HGAs). An algorithm to determine these parameters after launch has been developed and tested with simulated SDO data. The algorithm consists of a direct minimization of the root-sum-square of the differences between expected power and measured power. The results show that sufficient parameter accuracy can be attained even when time-dependent thermal distortions are present, if measurements from a pattern of intentional offset pointing positions is included.

  19. NASA/Cousteau ocean bathymetry experiment. Remote bathymetry using high gain LANDSAT data

    NASA Technical Reports Server (NTRS)

    Polcyn, F. C.

    1976-01-01

    Satellite remote bathymetry was varified to 22 m depths where water clarity was defined by alpha = .058 1/m and bottom reflection, r(b), was 26%. High gain band 4 and band 5 CCT data from LANDSAT 1 was used for a test site in the Bahama Islands and near Florida. Near Florida where alpha = .11 1/m and r(b) = 20%, depths to 10 m were verified. Depth accuracies within 10% rms were achieved. Position accuracies within one LANDSAT pixel were obtained by reference to the Transit navigation satellites. The Calypso and the Beayondan, two ships, were at anchor on each of the seven days during LANDSAT 1 and 2 overpasses: LORAN C position information was used when the ships were underway making depth transects. Results are expected to be useful for updating charts showing shoals hazardous to navigation or in monitoring changes in nearshore topography.

  20. A high gain patch fed horn antenna for millimeter wave imaging receiver

    NASA Astrophysics Data System (ADS)

    Shireen, Rownak; Hwang, Timothy; Shi, Shouyuan; Prather, D. W.

    2005-11-01

    In this paper, antennas that combine transitions from microstrip line / coplanar waveguide (CPW) to horn antenna in a single unit are presented. Conventional single layer microstrip patch antennas inherently suffer narrow operation bandwidth; to widen the frequency bandwidth, stacked patch antennas are used and high gain is achieved from the horn antenna. Here, microstrip line / CPW directly feeds the bottom patch while the top patch couples parasitically to the bottom patch. For -10 dB return loss, 25% bandwidth is achieved for both microstrip line to horn antenna (MSLTHA) at center frequency f0=17.5 GHz and for CPW to horn antenna (CPWTHA) at f0=97 GHz. The designs were optimized using 3D Finite Element Method (FEM) software HFSS by Ansoft Corporation. The optimal design of MSLTHA has been fabricated and characterized. The return loss and far field radiation pattern are measured and has been found in very good agreement with the simulation results.

  1. Suppression of higher mode excitation in a high gain relativistic klystron amplifier

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Xu, Z.; Jin, X.; Li, Z. H.; Tang, C. X.

    2012-02-01

    Suppressing higher mode excitation is very important in the high gain relativistic klystron amplifier because higher mode can seriously degrade klystron performance and cause pulse shortening. The mechanism of higher mode self-excitation is explored in the PIC simulation, and it is shown the coupling between cavities is the main cause of higher mode self-excitation. The coupling forms the positive feedback loop for higher mode to be excited just like that in the oscillator circuit. The formula for startup current of higher mode self-excitation is developed based on the coupling between cavities. And the corresponding methods are taken to avoid higher mode self-excitation. Finally, mode control is realized in the RKA with output power up to 1.02 GW when driven power is only few kilowatts.

  2. A Comparative Study of the Spontaneous Social Interactions of Children with High-Functioning Autism and Children with Asperger's Disorder

    ERIC Educational Resources Information Center

    Macintosh, Kathleen; Dissanayake, Cheryl

    2006-01-01

    A comparative observational study was undertaken of the spontaneous social interactions of children with high-functioning autism and Asperger's disorder. The sample comprised 20 children with high-functioning autism, 19 children with Asperger's disorder and 17 typically developing children matched on chronological age and overall mental age. A…

  3. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae).

    PubMed

    Ma, Ren-Yi; Zhang, Jiao-Lin; Cavaleri, Molly A; Sterck, Frank; Strijk, Joeri S; Cao, Kun-Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn), which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems.

  4. Convergent Evolution towards High Net Carbon Gain Efficiency Contributes to the Shade Tolerance of Palms (Arecaceae)

    PubMed Central

    Ma, Ren-Yi; Zhang, Jiao-Lin; Cavaleri, Molly A.; Sterck, Frank; Strijk, Joeri S.; Cao, Kun-Fang

    2015-01-01

    Most palm species occur in the shaded lower strata of tropical rain forests, but how their traits relate to shade adaptation is poorly understood. We hypothesized that palms are adapted to the shade of their native habitats by convergent evolution towards high net carbon gain efficiency (CGEn), which is given by the maximum photosynthetic rate to dark respiration rate ratio. Leaf mass per area, maximum photosynthetic rate, dark respiration and N and P concentrations were measured in 80 palm species grown in a common garden, and combined with data of 30 palm species growing in their native habitats. Compared to other species from the global leaf economics data, dicotyledonous broad-leaved trees in tropical rainforest or other monocots in the global leaf economics data, palms possessed consistently higher CGEn, achieved by lowered dark respiration and fairly high foliar P concentration. Combined phylogenetic analyses of evolutionary signal and trait evolution revealed convergent evolution towards high CGEn in palms. We conclude that high CGEn is an evolutionary strategy that enables palms to better adapt to shady environments than coexisting dicot tree species, and may convey advantages in competing with them in the tropical forest understory. These findings provide important insights for understanding the evolution and ecology of palms, and for understanding plant shade adaptations of lower rainforest strata. Moreover, given the dominant role of palms in tropical forests, these findings are important for modelling carbon and nutrient cycling in tropical forest ecosystems. PMID:26461108

  5. A High Efficiency Variable Gain Amplifier Circuit with Controllable Transconductance Amp

    NASA Astrophysics Data System (ADS)

    Okura, Tetsuro; Okura, Shunsuke; Ido, Toru; Taniguchi, Kenji

    A novel power reduction technique for a variable gain amplifier (VGA) with a two-stage operational amplifier is proposed. The technique improves the power consumption of a VGA by optimizing the bandwidth and the phase margin dynamically on all gain range of the VGA through controlling the input transconductance of opamp. A VGA utilizing the proposed technique shows 40% reduction of power consumption against a conventional VGA at the best condition of VGA gain range.

  6. Spontaneous Raman Scattering Measurements of Vibrational Non-Equilibrium in High-Speed Jets

    NASA Astrophysics Data System (ADS)

    Reising, Heath; Haller, Timothy; Clemens, Noel; Varghese, Philip

    2016-11-01

    Vibrational non-equilibrium is detected and quantified in a high-speed jet using spontaneous Raman scattering. The non-equilibrium is induced by rapid mixing of the different temperature streams of the jet and coflow which are approximately 500 K and 1000 K, respectively. Simultaneous measurements of vibrational and rotational temperatures are made using fits of time-averaged high-resolution Stokes spectra of both N2 and O2 to high fidelity models of the spectrum. Independent measurements of these two species temperatures show good agreement in rotational temperature while the vibrational temperatures show only N2 to have a strong non-equilibrium. This suggests that vibrational energy transfer between these two molecules is very inefficient at these conditions. Work is being conducted to extend the technique to single-shot measurements by employing a multiple-pass cell to increase the incident laser fluence in the measurement volume. This new capability will allow for statistics of vibrational temperature to be quantified. The instantaneous nature of the measurements will also allow the technique to be applied in regions of large temperature fluctuations, such as the base of a lifted turbulent jet flame, where time-average measurements are not valid. This work was supported by funding from the Air Force Office of Scientific Research.

  7. Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats

    PubMed Central

    Kagota, Satomi; Tamashiro, Akiko; Yamaguchi, Yu; Sugiura, Reiko; Kuno, Takayoshi; Nakamura, Kazuki; Kunitomo, Masaru

    2001-01-01

    Cyclic guanosine monophosphate (cyclic GMP)-mediated mechanism plays an important role in vasodilatation and blood pressure regulation. We investigated the effects of high salt intake on the nitric oxide (NO) – cyclic GMP signal transduction pathway regulating relaxation in aortas of spontaneously hypertensive rats (SHR).Four-week-old SHR and normotensive Wistar-Kyoto rats (WKY) received a normal salt diet (0.3% NaCl) or a high salt diet (8% NaCl) for 4 weeks.In aortic rings from SHR, endothelium-dependent relaxations in response to acetylcholine (ACh), adenosine diphosphate (ADP) and calcium ionophore A23187 were significantly impaired by the high salt intake. The endothelium-independent relaxations in response to sodium nitroprusside (SNP) and nitroglycerin were also impaired, but that to 8-bromo-cyclic GMP remained unchanged. On the other hand, high salt diet had no significant effects on the relaxations of aortic rings from WKY.In aortas from SHR, the release of NO stimulated by ACh was significantly enhanced, whereas the production of cyclic GMP induced by either ACh or SNP was decreased by the high salt intake.Western blot analysis showed that the protein level of endothelial NO synthase (eNOS) was slightly increased, whereas that of soluble guanylate cyclase (sGC) was dramatically reduced by the high salt intake.These results indicate that in SHR, excessive dietary salt can result in downregulation of sGC followed by decreased cyclic GMP production, which leads to impairment of vascular relaxation in responses to NO. It is notable that chronic high salt intake impairs the sGC/cyclic GMP pathway but not the eNOS/NO pathway. PMID:11606313

  8. Transportation-cyber-physical-systems-oriented engine cylinder pressure estimation using high gain observer

    NASA Astrophysics Data System (ADS)

    Li, Yong-Fu; Xiao-Pei, Kou; Zheng, Tai-Xiong; Li, Yin-Guo

    2015-05-01

    In transportation cyber-physical-systems (T-CPS), vehicle-to-vehicle (V2V) communications play an important role in the coordination between individual vehicles as well as between vehicles and the roadside infrastructures, and engine cylinder pressure is significant for engine diagnosis on-line and torque control within the information exchange process under V2V communications. However, the parametric uncertainties caused from measurement noise in T-CPS lead to the dynamic performance deterioration of the engine cylinder pressure estimation. Considering the high accuracy requirement under V2V communications, a high gain observer based on the engine dynamic model is designed to improve the accuracy of pressure estimation. Then, the analyses about convergence, converge speed and stability of the corresponding error model are conducted using the Laplace and Lyapunov method. Finally, results from combination of Simulink with GT-Power based numerical experiments and comparisons demonstrate the effectiveness of the proposed approach with respect to robustness and accuracy. Project supported by the National Natural Science Foundation of China (Grant No. 61304197), the Scientific and Technological Talents of Chongqing, China (Grant No. cstc2014kjrc-qnrc30002), the Key Project of Application and Development of Chongqing, China (Grant No. cstc2014yykfB40001), the Natural Science Funds of Chongqing, China (Grant No. cstc2014jcyjA60003), and the Doctoral Start-up Funds of Chongqing University of Posts and Telecommunications, China (Grant No. A2012-26).

  9. Characterization of a high-gain Ne-like Fe transient x-ray laser

    SciTech Connect

    Dunn, J; Facnov, A; Fournier, K B; Moon, S J; Osterheld, A; Pikuz, T; Shlyaptsev, V N

    1999-09-13

    The authors present experimental results of a high efficiency Ne-like Fe transient collisional excitation x-ray laser using the COMET 15 TW table-top laser system at LLNL. The plasma formation, ionization and collision excitation of the x-ray laser have been optimized using two sequential laser pulses: a plasma formation beam with 5 J energy of 600 ps duration and a pump beam with 5 J energy of 1.2 ps duration. Since the observation of strong lasing on the 255 {angstrom} 3p-3s J = 0-1 transition of Ne-like Fe, they have achieved high gains of 35 cm{sup {minus}1} and saturation of the x-ray laser. A five-stage traveling wave excitation enhances the strongest Fe 3p-3s 255 {angstrom} lasing line as well as additional x-ray lines. A careful characterization of the plasma column conditions using L-shell spectroscopy indicates the degree of ionization along the line focus.

  10. Normal Visual Acuity and Electrophysiological Contrast Gain in Adults with High-Functioning Autism Spectrum Disorder

    PubMed Central

    Tebartz van Elst, Ludger; Bach, Michael; Blessing, Julia; Riedel, Andreas; Bubl, Emanuel

    2015-01-01

    A common neurodevelopmental disorder, autism spectrum disorder (ASD), is defined by specific patterns in social perception, social competence, communication, highly circumscribed interests, and a strong subjective need for behavioral routines. Furthermore, distinctive features of visual perception, such as markedly reduced eye contact and a tendency to focus more on small, visual items than on holistic perception, have long been recognized as typical ASD characteristics. Recent debate in the scientific community discusses whether the physiology of low-level visual perception might explain such higher visual abnormalities. While reports of this enhanced, “eagle-like” visual acuity contained methodological errors and could not be substantiated, several authors have reported alterations in even earlier stages of visual processing, such as contrast perception and motion perception at the occipital cortex level. Therefore, in this project, we have investigated the electrophysiology of very early visual processing by analyzing the pattern electroretinogram-based contrast gain, the background noise amplitude, and the psychophysical visual acuities of participants with high-functioning ASD and controls with equal education. Based on earlier findings, we hypothesized that alterations in early vision would be present in ASD participants. This study included 33 individuals with ASD (11 female) and 33 control individuals (12 female). The groups were matched in terms of age, gender, and education level. We found no evidence of altered electrophysiological retinal contrast processing or psychophysical measured visual acuities. There appears to be no evidence for abnormalities in retinal visual processing in ASD patients, at least with respect to contrast detection. PMID:26379525

  11. High-gain harmonic generation of soft X-rays with the `fresh bunch` technique

    SciTech Connect

    Yu, Li-Hua; Ben-Zvi, I.

    1996-10-01

    We report numerical simulations (using the TDA code) and analytic verification of the generation of 64 {Angstrom} high power soft X- rays from an exponential regime single pass seeded FEL. The seed is generated in the FEL using the High Gain Harmonic Generation (HGHG) technique combined with the `Fresh bunch` technique. A seed pulse at 2944 {Angstrom} is generated by conventional laser techniques. The seed pulse produces an intense energy modulation of the rear part of a I GeV, 1245 {Angstrom} electron beam in a `modulator` wiggler. In the `radiator` wiggler, (resonant to 64 {Angstrom}), the energy modulation creates beam density modulation followed by radiation of the 46{sup th} harmonic of the seed. We use a magnetic delay to position the 64 A{Angstrom} radiation at the undisturbed front of the bunch to serve as a seed for a single pass, exponential growth FEL. After a 9 m long exponential section followed by a 7 m long tapered section the radiation power reaches 3.3 GW.

  12. Limiting high-frequency hearing aid gain in listeners with and without suspected cochlear dead regions.

    PubMed

    Mackersie, Carol L; Crocker, Tracy L; Davis, Rebecca A

    2004-01-01

    The purpose of this study was to compare threshold-matched ears with and without suspected cochlear dead regions in terms of the speech perception benefit from high-frequency amplification. The Threshold Equalizing Noise Test (TEN) was used to assess the presence of dead regions. Speech perception was measured while participants were wearing a hearing aid fit to approximate DSL[i/o] targets. Consonant identification of nonsense vowel-consonant-vowel combinations was measured in quiet using a forced-choice procedure. Phoneme recognition was measured at signal-to-noise ratios ranging from 0 to +15 dB using the Computer-Assisted Speech Perception Assessment test (CASPA). Recognition scores were obtained for unfiltered stimuli and stimuli that were low-pass filtered at the estimated boundary of the suspected dead regions, 1/2 octave above and 1 octave above the boundary. Filter settings for the ears without suspected dead regions were the same as settings of the threshold-matched counterpart. In quiet and in low levels of noise, speech perception scores were significantly higher for the wide-band (unfiltered) condition than for the filtered conditions, and performance was similar for the ears with and without suspected dead regions. In high levels of noise, mean scores were highest in the wide-band condition for the ears without suspected dead regions, but performance reached an asymptote for the ears with suspected dead regions. These results suggest that patients with cochlear dead regions may experience speech perception benefit from wide-band high-frequency gain in quiet and low levels of noise, but not in high levels of noise.

  13. Studies of relative gain and timing response of fine-mesh photomultiplier tubes in high magnetic fields

    SciTech Connect

    Sulkosky, V.; Allison, L.; Barber, C.; Cao, T.; Ilieva, Y.; Jin, K.; Kalicy, G.; Park, K.; Ton, N.; Zheng, X.

    2016-08-01

    We investigated the use of Hamamatsu fine-mesh photomultiplier tube assemblies H6152-70 and H6614-70 with regards to their gain and timing resolution in magnetic fields up to 1.9 T. Our results show that the H6614-70 assembly can operate reliably in magnetic fields exceeding 1.5 T, while preserving a reasonable timing resolution even with a gain reduction of a factor of ~100. The reduction of the relative gain of the H6152-70 is similar to the H6614-70's near 1.5 T, but its timing resolution worsens considerably at this high field.

  14. Studies of relative gain and timing response of fine-mesh photomultiplier tubes in high magnetic fields

    NASA Astrophysics Data System (ADS)

    Sulkosky, V.; Allison, L.; Barber, C.; Cao, T.; Ilieva, Y.; Jin, K.; Kalicy, G.; Park, K.; Ton, N.; Zheng, X.

    2016-08-01

    We investigated the use of Hamamatsu fine-mesh photomultiplier tube assemblies H6152-70 and H6614-70 with regard to their gain and timing resolution in magnetic fields up to 1.9 T. Our results show that the H6614-70 assembly can operate reliably in magnetic fields exceeding 1.5 T, while preserving a reasonable timing resolution even with a gain reduction of a factor of ≈100. The reduction of the relative gain of the H6152-70 is similar to the H6614-70's near 1.5 T, but its timing resolution worsens considerably at this high field.

  15. High dietary fat exacerbates weight gain and obesity in female liver fatty acid binding protein gene-ablated mice.

    PubMed

    Atshaves, Barbara P; McIntosh, Avery L; Storey, Stephen M; Landrock, Kerstin K; Kier, Ann B; Schroeder, Friedhelm

    2010-02-01

    Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary fat. Male and female wild-type (WT) and L-FABP gene-ablated mice, pair-fed a defined isocaloric control or high fat diet for 12 weeks, consumed equal amounts of food by weight and kcal. Male WT mice gained weight faster than their female WT counterparts regardless of diet. L-FABP gene ablation enhanced weight gain more in female than male mice-an effect exacerbated by high fat diet. Dual emission X-ray absorptiometry revealed high-fat fed male and female WT mice gained mostly fat tissue mass (FTM). L-FABP gene ablation increased FTM in female, but not male, mice-an effect also exacerbated by high fat diet. Concomitantly, L-FABP gene ablation decreased serum beta-hydroxybutyrate in male and female mice fed the control diet and, even more so, on the high-fat diet. Thus, L-FABP gene ablation decreased fat oxidation and sensitized all mice to weight gain as whole body FTM and LTM-with the most gain observed in FTM of control vs high-fat fed female L-FABP null mice. Taken together, these results indicate loss of L-FABP exacerbates weight gain and/or obesity in response to high dietary fat.

  16. Experimental characteristics of a high-gain free-electron laser amplifier operating at 8-mm and 2-mm wavelengths

    SciTech Connect

    Throop, A.L.; Orzechowski, T.J.; Anderson, B.R.; Chambers, F.W.; Clark, J.C.; Fawley, W.M.; Jong, R.A.; Halbach, K.; Hopkins, D.B.; Sessler, A.M.

    1987-06-08

    The Electron Laser Facility (ELF) at the Lawrence Livermore National Laboratory (LLNL) uses a high-current induction linac (3.5 MeV, 1000 A), in conjunction with a pulsed electromagnetic wiggler (4.0 M, 4000 G), to operate a free electron laser (FEL) that produces intense radiation in the microwave regime (2 to 8 mm). ELF is a high-gain, single-pass amplifier, using a commercial microwave source as an oscillator input (200 W-50 kW). Previous experiments at 35 GHz produced exponential gains of 40 dB/m, peak powers exceeding 1 GW, and beam-to-rf conversion efficiencies of 34%. Recent experiments at 140 GHz have demonstrated exponential gains of 22 dB/m, peak powers exceeding 50 MW, and total gains of 65 dB. In this paper, we describe the experimental results at these two frequencies and compare then with the predictions of simulation codes.

  17. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease.

    PubMed

    Dibble, Leland E; Hale, Tessa F; Marcus, Robin L; Droge, John; Gerber, J Parry; LaStayo, Paul C

    2006-09-01

    Strength deficits in persons with Parkinson's disease (PD) have been identified as a contributor to bradykinesia. However, there is little research that examines the effect of resistance training on muscle size, muscle force production, and mobility in persons with PD. The purpose of this exploratory study was to examine, in persons with PD, the changes in quadriceps muscle volume, muscle force production, and mobility as a result of a 12-week high-force eccentric resistance training program and to compare the effects to a standard-care control. Nineteen individuals with idiopathic PD were recruited and consented to participate. Matched assignment for age and disease severity resulted in 10 participants in the eccentric group and 9 participants in the control group. All participants were tested prior to and following a 12-week intervention period with testing and training conducted at standardized times in their medication cycle. The eccentric group performed high-force quadriceps contractions on an eccentric ergometer 3 days a week for 12 weeks. The standard-care group exercise program encompassed standard exercise management of PD. The outcome variables were quadriceps muscle volume, muscle force, and mobility measures (6-minute walk, stair ascent/descent time). Each outcome variable was tested using separate one-way analyses of covariance on the difference scores. Muscle volume, muscle force, and functional status improvements occurred in persons with PD as a result of high-force eccentric resistance training. The eccentric group demonstrated significantly greater difference scores for muscle structure, stair descent, and 6-minute walk (P < 0.05). Magnitude of effect size estimators for the eccentric group consistently exceeded those in the standard-care group for all variables. To our knowledge, this is the first clinical trial to investigate and demonstrate the effects of eccentric resistance training on muscle hypertrophy, strength, and mobility in persons

  18. Spontaneous high-gamma band activity reflects functional organization of auditory cortex in the awake macaque.

    PubMed

    Fukushima, Makoto; Saunders, Richard C; Leopold, David A; Mishkin, Mortimer; Averbeck, Bruno B

    2012-06-07

    In the absence of sensory stimuli, spontaneous activity in the brain has been shown to exhibit organization at multiple spatiotemporal scales. In the macaque auditory cortex, responses to acoustic stimuli are tonotopically organized within multiple, adjacent frequency maps aligned in a caudorostral direction on the supratemporal plane (STP) of the lateral sulcus. Here, we used chronic microelectrocorticography to investigate the correspondence between sensory maps and spontaneous neural fluctuations in the auditory cortex. We first mapped tonotopic organization across 96 electrodes spanning approximately two centimeters along the primary and higher auditory cortex. In separate sessions, we then observed that spontaneous activity at the same sites exhibited spatial covariation that reflected the tonotopic map of the STP. This observation demonstrates a close relationship between functional organization and spontaneous neural activity in the sensory cortex of the awake monkey.

  19. Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs.

    PubMed

    Chan, Allen W; Mohajerani, Majid H; LeDue, Jeffrey M; Wang, Yu Tian; Murphy, Timothy H

    2015-07-20

    Neuroimaging of spontaneous, resting-state infraslow (<0.1 Hz) brain activity has been used to reveal the regional functional organization of the brain and may lead to the identification of novel biomarkers of neurological disease. However, these imaging studies generally rely on indirect measures of neuronal activity and the nature of the neuronal activity correlate remains unclear. Here we show, using wide-field, voltage-sensitive dye imaging, the mesoscale spatiotemporal structure and pharmacological dependence of spontaneous, infraslow cortical activity in anaesthetized and awake mice. Spontaneous infraslow activity is regionally distinct, correlates with electroencephalography and local field potential recordings, and shows bilateral symmetry between cortical hemispheres. Infraslow activity is attenuated and its functional structure abolished after treatment with voltage-gated sodium channel and glutamate receptor antagonists. Correlation analysis reveals patterns of infraslow regional connectivity that are analogous to cortical motifs observed from higher-frequency spontaneous activity and reflect the underlying framework of intracortical axonal projections.

  20. Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs

    PubMed Central

    Chan, Allen W.; Mohajerani, Majid H.; LeDue, Jeffrey M.; Wang, Yu Tian; Murphy, Timothy H.

    2016-01-01

    Neuroimaging of spontaneous, resting-state infraslow (<0.1 Hz) brain activity has been used to reveal the regional functional organization of the brain and may lead to the identification of novel biomarkers of neurological disease. However, these imaging studies generally rely on indirect measures of neuronal activity and the nature of the neuronal activity correlate remains unclear. Here we show, using wide-field, voltage-sensitive dye imaging, the mesoscale spatiotemporal structure and pharmacological dependence of spontaneous, infraslow cortical activity in anaesthetized and awake mice. Spontaneous infraslow activity is regionally distinct, correlates with electroencephalography and local field potential recordings, and shows bilateral symmetry between cortical hemispheres. Infraslow activity is attenuated and its functional structure abolished after treatment with voltage-gated sodium channel and glutamate receptor antagonists. Correlation analysis reveals patterns of infraslow regional connectivity that are analogous to cortical motifs observed from higher-frequency spontaneous activity and reflect the underlying framework of intracortical axonal projections. PMID:26190168

  1. Prospects for high-gain, high yield National Ignition Facility targets driven by 2(omega) (green) light

    SciTech Connect

    Suter, L J; Glenzer, S; Haan, S; Hammel, B; Manes, K; Meezan, N; Moody, J; Spaeth, M; Divol, L; Oades, K; Stevenson, M

    2003-12-16

    The National Ignition Facility (NIF), operating at green (2{omega}) light, has the potential to drive ignition targets with significantly more energy than the 1.8 MJ it will produce with its baseline, blue (3{omega}) operations. This results in a greatly increased 'target design space', providing a number of exciting opportunities for fusion research. These include the prospect of ignition experiments with capsules absorbing energies in the vicinity of 1 MJ. This significant increase in capsule absorbed energy over the original designs at {approx}150 kJ could allow high-gain, high yield experiments on NIF. This paper reports the progress made exploring 2{omega} for NIF ignition, including potential 2{omega} laser performance, 2{omega} ignition target designs and 2{omega} Laser Plasma Interaction (LPI) studies.

  2. High-gain test facility driven by a multimegajoule solid-state laser

    SciTech Connect

    Powell, H.T.; Manes, K.R.; Hogan, W.J.

    1986-01-01

    An ICF high-gain test facility (HGTF) will most certainly be in demand for other applications than ICF target physics. These will include advanced weapon physics, vulnerability and nuclear effects, and x-ray laser studies. These other applications will place additional demands on driver flexibility and will extend the desirable range of some of the driver variables (e.g., the desirable pulse length range would be 0.1 to 100 ns and the wavelength range would be 0.25 to 1.0 ..mu..m). It is also likely that to utilize the driver efficiently for the variety of applications foreseen will require multiple target chambers and experiment areas. Thus, it is important that the driver beams be efficiently transported to these different experimental areas. At the present time, the only driver capable of meeting this broad set of requirements is the Nd:glass laser. It has long been believed that an Nd:glass laser with the above requirements could be built but that it would be unreasonably expensive. There is still much work to be done. However, the progress to date and the track record for lowering system cost in past solid-state facilities, leads us to be optimistic that we can achieve our goal of building an affordable HGTF that will meet all the requirements.

  3. A Modified Lunar Reconnaissance Orbiter (LRO) High Gain Antenna (HGA) Controller Based on Flight Performance

    NASA Technical Reports Server (NTRS)

    Shah, Neerav

    2010-01-01

    The National Aeronautics and Space Administration's (NASA) Lunar Reconnaissance Orbiter (LRO) was launched on June 18, 2009 and is currently in a 50 km mean altitude polar orbit around the Moon. LRO was designed and built by the NASA Goddard Space Flight Center in Greenbelt, MD. The spacecraft is three-axis stabilized via the attitude control system (ACS), which is composed of various control modes using different sets of sensors and actuators. In addition to pointing the spacecraft, the ACS is responsible for pointing LRO s two appendages, the Solar Array (SA) and the High Gain Antenna (HGA). This study reviews LRO s HGA control system. Starting with an overview of the HGA system, the paper delves into the single input single output (SISO) linear analysis followed by the controller design. Based on flight results, an alternate control scheme is devised to address inherent features in the flight control system. The modified control scheme couples the HGA loop with the spacecraft pointing control loop, and through analysis is shown to be stable and improve transient performance. Although proposed, the LRO project decided against implementing this modification.

  4. Spacecraft Angular Rates Estimation with Gyrowheel Based on Extended High Gain Observer

    PubMed Central

    Liu, Xiaokun; Yao, Yu; Ma, Kemao; Zhao, Hui; He, Fenghua

    2016-01-01

    A gyrowheel (GW) is a kind of electronic electric-mechanical servo system, which can be applied to a spacecraft attitude control system (ACS) as both an actuator and a sensor simultaneously. In order to solve the problem of two-dimensional spacecraft angular rate sensing as a GW outputting three-dimensional control torque, this paper proposed a method of an extended high gain observer (EHGO) with the derived GW mathematical model to implement the spacecraft angular rate estimation when the GW rotor is working at large angles. For this purpose, the GW dynamic equation is firstly derived with the second kind Lagrange method, and the relationship between the measurable and unmeasurable variables is built. Then, the EHGO is designed to estimate and calculate spacecraft angular rates with the GW, and the stability of the designed EHGO is proven by the Lyapunov function. Moreover, considering the engineering application, the effect of measurement noise in the tilt angle sensors on the estimation accuracy of the EHGO is analyzed. Finally, the numerical simulation is performed to illustrate the validity of the method proposed in this paper. PMID:27089347

  5. BiCMOS operational amplifier with precise and stable dc gain for high-frequency switched capacitor circuits

    NASA Astrophysics Data System (ADS)

    Baschirotto, A.; Alini, R.; Castello, R.

    1991-07-01

    A novel approach in the design of high-frequency switched capacitor (SC) circuits is presented. It is based on the use of simple and fast amplifiers with low but precisely controlled gain value. The effect of the precisely known and stable opamp gain is compensated for by changing the capacitor values during the synthesis of the SC cell. An example of an opamp with these features and the synthesis of a biquadratic filter based on this approach are given.

  6. Commensal E. coli Stx2 lysogens produce high levels of phages after spontaneous prophage induction.

    PubMed

    Iversen, Hildegunn; L' Abée-Lund, Trine M; Aspholm, Marina; Arnesen, Lotte P S; Lindbäck, Toril

    2015-01-01

    Enterohemorrhagic E. coli (EHEC) is a food-borne pathogen that causes disease ranging from uncomplicated diarrhea to life-threatening hemolytic uremic syndrome (HUS) and nervous system complications. Shiga toxin 2 (Stx2) is the major virulence factor of EHEC and is critical for development of HUS. The genes encoding Stx2 are carried by lambdoid bacteriophages and the toxin production is tightly linked to the production of phages during lytic cycle. It has previously been suggested that commensal E. coli could amplify the production of Stx2-phages and contribute to the severity of disease. In this study we examined the susceptibility of commensal E. coli strains to the Stx2-converting phage ϕ734, isolated from a highly virulent EHEC O103:H25 (NIPH-11060424). Among 38 commensal E. coli strains from healthy children below 5 years, 15 were lysogenized by the ϕ734 phage, whereas lytic infection was not observed. Three of the commensal E. coli ϕ734 lysogens were tested for stability, and appeared stable and retained the phage for at least 10 cultural passages. When induced to enter lytic cycle by H2O2 treatment, 8 out of 13 commensal lysogens produced more ϕ734 phages than NIPH-11060424. Strikingly, five of them even spontaneously (non-induced) produced higher levels of phage than the H2O2 induced NIPH-11060424. An especially high frequency of HUS (60%) was seen among children infected by NIPH-11060424 during the outbreak in 2006. Based on our findings, a high Stx2 production by commensal E. coli lysogens cannot be ruled out as a contributor to the high frequency of HUS during this outbreak.

  7. High spatial resolution BOTDA using simultaneously launched gain and loss pump pulses

    NASA Astrophysics Data System (ADS)

    Motil, A.; Danon, O.; Peled, Y.; Tur, M.

    2013-05-01

    We report a 10cm spatial resolution in a Brillouin-based distributed sensing system using two simultaneously launched gain and loss pump pulses, having slightly different durations. Post-recording subtraction of the probe signal, excited by the shorter pulse, from the corresponding one, obtained from the longer pump pulse, is no longer required, since it is done automatically by the overlapping parts of the gain and loss pump pulses. Using a 30ns gain pump pulse and a 29ns loss pump pulse we were able to improve upon previously published results, achieving a distributed strain measurement along a standard single mode optical fiber with a spatial resolution of ~10cm. This technique does not broaden the involved Brillouin gain spectra so that the strain/temperature sensitivity is not compromised.

  8. Spontaneous transitions in atomic system in the presence of high-intensity laser field

    NASA Astrophysics Data System (ADS)

    Bogatskaya, Anna; Volkova, Ekaterina; Popov, Alexander

    2016-10-01

    A new approach to the study of the spontaneous emission of the quantum system driven by a high-intensity laser field is developed. This approach is based on the accurate consideration of quantum system interaction with vacuum quantized field modes in the first order of perturbation theory, while the intense laser field is considered classically beyond the perturbation theory which allows to observe any-order stimulated processes governed by classical field. The proposed approach is applied to the study of a number of quantum systems in intense laser field. The obtained data are compared with those obtained in the frames of semiclassical approximation typically used for analyzing of the strong-field dynamic. It is found that the applicability of the semiclassical approach is strictly limited. It is valid for calculation of transitions to the initially populated state only if the population of this state is close to unity during the pulse and in the after-pulse regime. If its population is depleted, the semiclassical approach fails.

  9. The H II Region KR 140: Spontaneous Formation of a High-Mass Star

    NASA Astrophysics Data System (ADS)

    Ballantyne, D. R.; Kerton, C. R.; Martin, P. G.

    2000-08-01

    We have used a multiwavelength data set from the Canadian Galactic Plane Survey (CGPS) to study the Galactic H II region KR 140, both on the scale of the nebula itself and in the context of the star-forming activity in the nearby W3/W4/W5 complex of molecular clouds and H II regions. From both radio and infrared data we have found a covering factor of about 0.5 for KR 140, and we interpret the nebula as a bowl-shaped region viewed close to face on. Extinction measurements place the region on the near side of its parent molecular cloud. The nebula is kept ionized by one O8.5 V(e) star, VES 735, which is less than a few million years old. CO data show that VES 735 has disrupted much of the original molecular cloud for which the estimated mass and density are about 5000 Msolar and 100 cm-3, respectively. KR 140 is isolated from the nearest star-forming activity, in W3. Our data suggest that KR 140 is an example of spontaneous (i.e., nontriggered) formation of, unusually, a high-mass star.

  10. D-β-aspartyl residue exhibiting uncommon high resistance to spontaneous peptide bond cleavage

    NASA Astrophysics Data System (ADS)

    Aki, Kenzo; Okamura, Emiko

    2016-02-01

    Although L-amino acids were selected as main constituents of peptides and proteins during chemical evolution, D-aspartyl (Asp) residue is found in a variety of living tissues. In particular, D-β-Asp is thought to be stable than any other Asp isomers, and this could be a reason for gradual accumulation in abnormal proteins and peptides to modify their structures and functions. It is predicted that D-β-Asp shows high resistance to biomolecular reactions. For instance, less reactivity of D-β-Asp is expected to bond cleavage, although such information has not been provided yet. In this work, the spontaneous peptide bond cleavage was compared between Asp isomers, by applying real-time solution-state NMR to eye lens αΑ-crystallin 51–60 fragment, S51LFRTVLD58SG60 and αΒ-crystallin 61–67 analog, F61D62TGLSG67 consisting of L-α- and D-β-Asp 58 and 62, respectively. Kinetic analysis showed how tough the uncommon D-β-Asp residue was against the peptide bond cleavage as compared to natural L-α-Asp. Differences in pKa and conformation between L-α- and D-β-Asp side chains were plausible factors to determine reactivity of Asp isomers. The present study, for the first time, provides a rationale to explain less reactivity of D-β-Asp to allow abnormal accumulation.

  11. High-gain AlGaAs/GaAs double heterojunction Darlington phototransistors for optical neural networks

    NASA Technical Reports Server (NTRS)

    Kim, Jae H. (Inventor); Lin, Steven H. (Inventor)

    1991-01-01

    High-gain MOCVD-grown (metal-organic chemical vapor deposition) AlGaAs/GaAs/AlGaAs n-p-n double heterojunction bipolar transistors (DHBTs) and Darlington phototransistor pairs are provided for use in optical neural networks and other optoelectronic integrated circuit applications. The reduced base doping level used results in effective blockage of Zn out-diffusion, enabling a current gain of 500, higher than most previously reported values for Zn-diffused-base DHBTs. Darlington phototransitor pairs of this material can achieve a current gain of over 6000, which satisfies the gain requirement for optical neural network designs, which advantageously may employ neurons comprising the Darlington phototransistor pairs in series with a light source.

  12. Verification of the Solar Dynamics Observatory High Gain Antenna Pointing Algorithm Using Flight Data

    NASA Technical Reports Server (NTRS)

    Bourkland, Kristin L.; Liu, Kuo-Chia

    2011-01-01

    The Solar Dynamics Observatory (SDO), launched in 2010, is a NASA-designed spacecraft built to study the Sun. SDO has tight pointing requirements and instruments that are sensitive to spacecraft jitter. Two High Gain Antennas (HGAs) are used to continuously send science data to a dedicated ground station. Preflight analysis showed that jitter resulting from motion of the HGAs was a cause for concern. Three jitter mitigation techniques were developed and implemented to overcome effects of jitter from different sources. These mitigation techniques include: the random step delay, stagger stepping, and the No Step Request (NSR). During the commissioning phase of the mission, a jitter test was performed onboard the spacecraft, in which various sources of jitter were examined to determine their level of effect on the instruments. During the HGA portion of the test, the jitter amplitudes from the single step of a gimbal were examined, as well as the amplitudes due to the execution of various gimbal rates. The jitter levels were compared with the gimbal jitter allocations for each instrument. The decision was made to consider implementing two of the jitter mitigating techniques on board the spacecraft: stagger stepping and the NSR. Flight data with and without jitter mitigation enabled was examined, and it is shown in this paper that HGA tracking is not negatively impacted with the addition of the jitter mitigation techniques. Additionally, the individual gimbal steps were examined, and it was confirmed that the stagger stepping and NSRs worked as designed. An Image Quality Test was performed to determine the amount of cumulative jitter from the reaction wheels, HGAs, and instruments during various combinations of typical operations. The HGA-induced jitter on the instruments is well within the jitter requirement when the stagger step and NSR mitigation options are enabled.

  13. High gain GaAs Photoconductive Semiconductor Switches (PCSS): Device lifetime, high current testing, optical pulse generators

    SciTech Connect

    Zutavern, F.J.; Loubriel, G.M.; Helgeson, W.D.; O`Malley, M.W.; Gallegos, R.R.; Hjalmarson, H.P.; Baca, A.G.; Plut, T.A.

    1995-12-31

    This paper presents results from three areas of GaAs PCSS research and development: device lifetime, high current switching, and PCSS-driven laser diode arrays (LDA). The authors have performed device lifetime tests on both lateral and vertical switches as a function of current amplitude, pulse width, and charging time. At present, their longest-lived switch reached 4 {times} 10{sup 6} pulses. Scanning electron microscope (SEM) images show damage near the contacts even after only 5 pulses. They are presently searching for the threshold at which no damage is evident after a single shot. In high current tests, they have reached 5.2 kA at 4.2 kV. This was achieved using twenty fiber-optic coupled lasers to distribute current filaments over a 5 mm wide PCSS. Current waveforms and images of the current filaments as a function of current amplitude will be presented. The lasers used to trigger the high current PCSS were driven with a miniature PCSS. Low inductance, high speed GaAs PCSS are very effective as short pulse laser diode array drivers. Some types of arrays gain switch, producing a compressed optical pulse which is only 75 ps wide. Results from tests with a variety of laser diode arrays will be presented.

  14. Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice.

    PubMed

    McIntosh, Avery L; Atshaves, Barbara P; Landrock, Danilo; Landrock, Kerstin K; Martin, Gregory G; Storey, Stephen M; Kier, Ann B; Schroeder, Friedhelm

    2013-05-01

    Loss of liver fatty acid binding protein (L-FABP) decreases long chain fatty acid uptake and oxidation in primary hepatocytes and in vivo. On this basis, L-FABP gene ablation would potentiate high-fat diet-induced weight gain and weight gain/energy intake. While this was indeed the case when L-FABP null (-/-) mice on the C57BL/6NCr background were pair-fed a high-fat diet, whether this would also be observed under high-fat diet fed ad libitum was not known. Therefore, this possibility was examined in female L-FABP (-/-) mice on the same background. L-FABP (-/-) mice consumed equal amounts of defined high-fat or isocaloric control diets fed ad libitum. However, on the ad libitum-fed high-fat diet the L-FABP (-/-) mice exhibited: (1) decreased hepatic long chain fatty acid (LCFA) β-oxidation as indicated by lower serum β-hydroxybutyrate level; (2) decreased hepatic protein levels of key enzymes mitochondrial (rate limiting carnitine palmitoyl acyltransferase A1, CPT1A; HMG-CoA synthase) and peroxisomal (acyl CoA oxidase 1, ACOX1) LCFA β-oxidation; (3) increased fat tissue mass (FTM) and FTM/energy intake to the greatest extent; and (4) exacerbated body weight gain, weight gain/energy intake, liver weight, and liver weight/body weight to the greatest extent. Taken together, these findings showed that L-FABP gene-ablation exacerbated diet-induced weight gain and fat tissue mass gain in mice fed high-fat diet ad libitum--consistent with the known biochemistry and cell biology of L-FABP.

  15. High energy gain in three-dimensional simulations of light sail acceleration

    SciTech Connect

    Sgattoni, A.; Sinigardi, S.; Macchi, A.

    2014-08-25

    The dynamics of radiation pressure acceleration in the relativistic light sail regime are analysed by means of large scale, three-dimensional (3D) particle-in-cell simulations. Differently to other mechanisms, the 3D dynamics leads to faster and higher energy gain than in 1D or 2D geometry. This effect is caused by the local decrease of the target density due to transverse expansion leading to a “lighter sail.” However, the rarefaction of the target leads to an earlier transition to transparency limiting the energy gain. A transverse instability leads to a structured and inhomogeneous ion distribution.

  16. Modelling Plant and Soil Nitrogen Feedbacks Affecting Forest Carbon Gain at High CO2

    NASA Astrophysics Data System (ADS)

    McMurtrie, R. E.; Norby, R. J.; Franklin, O.; Pepper, D. A.

    2007-12-01

    Short-term, direct effects of elevated atmospheric CO2 concentrations on plant carbon gain are relatively well understood. There is considerable uncertainty, however, about longer-term effects, which are influenced by various plant and ecosystem feedbacks. A key feedback in terrestrial ecosystems occurs through changes in plant carbon (C) allocation patterns. For instance, if high CO2 were to increase C allocation to roots, then plants may experience positive feedback through improved plant nutrition. A second type of feedback, associated with decomposition of soil-organic matter, may reduce soil-nutrient availability at high CO2. This paper will consider mechanistic models of both feedbacks. Effects of high CO2 on plant C allocation will be investigated using a simple model of forest net primary production (NPP) that incorporates the primary mechanisms of plant carbon and nitrogen (N) balance. The model called MATE (Model Any Terrestrial Ecosystem) includes an equation for annual C balance that depends on light- saturated photosynthetic rate and therefore on [CO2], and an equation for N balance incorporating an expression for N uptake as a function of root mass. The C-N model is applied to a Free Air CO2 Exchange (FACE) experiment at Oak Ridge National Laboratory (ORNL) in Tennessee, USA, where closed-canopy, monoculture stands of the deciduous hardwood sweetgum ( Liquidambar styraciflua) have been growing at [CO2] of 375 and 550 ppm for ten years. Features of this experiment are that the annual NPP response to elevated CO2 has averaged approximately 25% over seven years, but that annual fine-root production has almost doubled on average, with especially large increases in later years of the experiment (Norby et al. 2006). The model provides a simple graphical approach for analysing effects of elevated CO2 and N supply on leaf/root/wood C allocation and productivity. It simulates increases in NPP and fine-root production at the ORNL FACE site that are consistent

  17. The Linguistic Gains and Acculturation of American High School Students on Exchange Programs in Germany

    ERIC Educational Resources Information Center

    Lovitt, Ashli

    2013-01-01

    There has been a sharp rise in study abroad participation over the last few decades (Institute for International Education, 2011), which can largely be explained by the rise of short-term study abroad programs. While there is much to be gained from participation in such programs, mid-length and year programs may offer the greatest benefits for…

  18. Light-controlled resistors provide quadrature signal rejection for high-gain servo systems

    NASA Technical Reports Server (NTRS)

    Mc Cauley, D. D.

    1967-01-01

    Servo amplifier feedback system, in which the phase sensitive detection, low pass filtering, and multiplication functions required for quadrature rejection, are preformed by light-controlled photoresistors, eliminates complex circuitry. System increases gain, improves signal-to-noise ratio, and eliminates the necessity for compensation.

  19. Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice.

    PubMed

    Vaanholt, L M; Sinclair, R E; Mitchell, S E; Speakman, J R

    2015-05-15

    Easy access to high-energy palatable foods has been suggested to have contributed to the world-wide obesity epidemic. However, within these 'obesogenic' environments many people manage to remain lean. Mice also show variability in their weight gain responses to high-fat diet (HFD) feeding and their weight loss responses to calorically restricted (CR) feeding. In this study we investigated which factors contribute to determining susceptibility to HFD-induced obesity in mice, and whether the responses in weight gain on HFD are correlated with the responses to CR. One-hundred twenty four mice were exposed to 30% CR for 28days followed by a 14day recovery period, and subsequent exposure to 60% HFD for 28days. Responses in various metabolic factors were measured before and after each exposure (body mass; BM, body composition, food intake; FI, resting metabolic rate; RMR, physical activity, body temperature and glucose tolerance; GT). Weight changes on HFD ranged from -1 to 26%, equivalent to -0.2g to 10.5g in absolute mass. Multiple regression models showed that fat free mass (FFM) of the mice before exposure to HFD predicted 12% of the variability in weight gain on HFD (p<0.001). Also, FI during the first week of HFD feeding predicted 20% of the variability in BM and fat mass (FM) gain 4weeks later. These data may point to a role for the reward system in driving individual differences in FI and weight gain. Weight gain on the HFD was significantly negatively correlated to weight loss on CR, indicating that animals that are poor at defending against weight gain on HFD, were also poor at defending against CR-induced weight loss. Changes in FM and FFM in response to HFD or CR were not correlated however.

  20. Verification of the Solar Dynamics Observatory High Gain Antenna Pointing Algorithm Using Flight Data

    NASA Technical Reports Server (NTRS)

    Bourkland, Kristin L.; Liu, Kuo-Chia

    2011-01-01

    The Solar Dynamics Observatory (SDO) is a NASA spacecraft designed to study the Sun. It was launched on February 11, 2010 into a geosynchronous orbit, and uses a suite of attitude sensors and actuators to finely point the spacecraft at the Sun. SDO has three science instruments: the Atmospheric Imaging Assembly (AIA), the Helioseismic and Magnetic Imager (HMI), and the Extreme Ultraviolet Variability Experiment (EVE). SDO uses two High Gain Antennas (HGAs) to send science data to a dedicated ground station in White Sands, New Mexico. In order to meet the science data capture budget, the HGAs must be able to transmit data to the ground for a very large percentage of the time. Each HGA is a dual-axis antenna driven by stepper motors. Both antennas transmit data at all times, but only a single antenna is required in order to meet the transmission rate requirement. For portions of the year, one antenna or the other has an unobstructed view of the White Sands ground station. During other periods, however, the view from both antennas to the Earth is blocked for different portions of the day. During these times of blockage, the two HGAs take turns pointing to White Sands, with the other antenna pointing out to space. The HGAs handover White Sands transmission responsibilities to the unblocked antenna. There are two handover seasons per year, each lasting about 72 days, where the antennas hand off control every twelve hours. The non-tracking antenna slews back to the ground station by following a ground commanded trajectory and arrives approximately 5 minutes before the formerly tracking antenna slews away to point out into space. The SDO Attitude Control System (ACS) runs at 5 Hz, and the HGA Gimbal Control Electronics (GCE) run at 200 Hz. There are 40 opportunities for the gimbals to step each ACS cycle, with a hardware limitation of no more than one step every three GCE cycles. The ACS calculates the desired gimbal motion for tracking the ground station or for slewing

  1. Ultrafast laser inscription of a high-gain Er-doped bismuthate glass waveguide amplifier.

    PubMed

    Thomson, Robert R; Psaila, Nicholas D; Beecher, Stephen J; Kar, Ajoy K

    2010-06-07

    An Er-doped bismuthate glass waveguide amplifier has been fabricated using ultrafast laser inscription. Under zero pump conditions, the 87.0 mm long waveguide exhibited a fiber-to-fiber insertion loss of 4.0 dB at 1618 nm, outside the Er(3+) ion absorption band. We attribute approximately 1.8 dB of the insertion loss to coupling losses, 0.2 dB to Fresnel reflections and approximately 2.0 dB to propagation losses. When pumped using 1050 mW of 980 nm light, the amplifier exhibited a peak internal gain per unit length of 2.3 dB.cm(-1) at 1533 nm and a peak fiber-to-fiber net gain of 16.0 dB at 1533 nm. In this paper we also report the results of output power saturation and noise figure measurements.

  2. A numerical algorithm for optimal feedback gains in high dimensional LQR problems

    NASA Technical Reports Server (NTRS)

    Banks, H. T.; Ito, K.

    1986-01-01

    A hybrid method for computing the feedback gains in linear quadratic regulator problems is proposed. The method, which combines the use of a Chandrasekhar type system with an iteration of the Newton-Kleinman form with variable acceleration parameter Smith schemes, is formulated so as to efficiently compute directly the feedback gains rather than solutions of an associated Riccati equation. The hybrid method is particularly appropriate when used with large dimensional systems such as those arising in approximating infinite dimensional (distributed parameter) control systems (e.g., those governed by delay-differential and partial differential equations). Computational advantage of the proposed algorithm over the standard eigenvector (Potter, Laub-Schur) based techniques are discussed and numerical evidence of the efficacy of our ideas presented.

  3. High-power gain-switched Tm(3+)-doped fiber laser.

    PubMed

    Tang, Yulong; Xu, Lin; Yang, Yi; Xu, Jianqiu

    2010-10-25

    Gain-switched by a 1.914-µm Tm:YLF crystal laser, a two-stage Tm(3+) fiber laser has been achieved 100-W level ~2-µm pulsed laser output with a slope efficiency of ~52%. With the 6-m length of Tm fiber, the laser wavelength was centered at 2020 nm with a bandwidth of ~25 nm. Based on an acousto-optic switch, the pulse repetition rate can be modulated from 500 Hz to 50 kHz, and the laser pulse width can be tuned between 75 ns and ~1 µs. The maximum pulse energy was over 10 mJ, and the maximum pulse peak power was 138 kW. By using the fiber-coiling-induced mode-filtering effect, laser beam quality of M2 = 1.01 was obtained. Further scaling the pulse energy and average power from such kind of gain-switched fiber lasers was also discussed.

  4. Burst-mode gain switched technique for high peak and average optical energy extraction.

    PubMed

    Nikumb, S K; Seguin, H J; Seguin, V A; Willis, R J; Cheng, Z; Reshef, H

    1989-05-01

    The optical performance of a cw PIE CO(2) laser has been substantially improved through the adoption of a burst-mode gain switching technique. The approach has provided a doubling of the average beam power extractable from the device. With appropriate optimization, the process could possibly permit the attainment of pulsed energy extraction in the kilohertz range, and with average optical powers within the several tens of kilowatt category.

  5. Investigations of SBS and Laser Gain Competition in High-Power Phase Modulated Fiber Amplifiers (Postprint)

    DTIC Science & Technology

    2014-02-26

    through radio frequency (RF) phase modulation. Generally, linewidth broadening is achieved through a filtered microwave white noise source (WNS). WNS...signals. By seeding with appropriate wavelengths and seed powers, the effective length of the amplifier is shortened as the narrow linewidth signal...line (phase modulated) 1064 nm seed in conjunction with a broadband 1036 nm seed source. 2. PHASE MODULATED LASER GAIN COMPETITION Recently, we have

  6. High Gain, Fast Scan, Broad Spectrum, Parallel Beam Wavelength Dispersive X-ray Spectrometer for SEM

    SciTech Connect

    David OHara; Dr. Eric Lochmer

    2003-09-12

    Parallax Research, Inc. proposes to produce a new type of x-ray spectrometer for use with Scanning Electron Microscopy (SEM) that would have the energy resolution of WDS and the ease of use of EDS with sufficient gain for lower energies that it can be used at low beam currents as is EDS. Parallax proposes to do this by development of new multiple reflection x-ray collimation optics, new diffractor technology, new detector technology and new scan algorithms.

  7. Compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode.

    PubMed

    Liu, Hongjun; Gao, Cunxiao; Tao, Jintao; Zhao, Wei; Wang, Yishan

    2008-05-26

    A compact tunable high power picosecond source based on Yb-doped fiber amplification of gain switch laser diode is demonstrated. A multi-stage single mode Yb-doped fiber preamplifier was combined with a single mode double-clad Yb-doped fiber main amplifier to construct the amplification system, which is seeded by a gain switch laser diode. By optimizing preamplifier???s parameters to compensate the seed spectrum gain, a "flat top" broadband spectrum is obtained to realize wavelength tunable output with a self-made tunable filter. The tunable pulses were further amplified to 3.5 W average power 90 ps pulses at 1 MHz repetition rate, and the center wavelength was tunable in the ranges from 1053 nm to 1073 nm with excellent beam quality.

  8. High-gain dipole antenna using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate for 5G applications

    NASA Astrophysics Data System (ADS)

    Muhamad, Wan Asilah Wan; Ngah, Razali; Jamlos, Mohd Faizal; Soh, Ping Jack; Ali, Mohd Tarmizi

    2017-01-01

    A new dipole antenna designed using polydimethylsiloxane-glass microsphere (PDMS-GM) substrate is presented. The PDMS-GM substrate offered a lower permittivity of 1.85 compared to pure PDMS of 2.7. This resulted in a wide operating frequency range from 19 GHz up to more than 45 GHz, indicating a bandwidth of more than 28 GHz. The proposed PDMS-GM antenna featured a gain of up to 13.3 dB compared to pure PDMS which only produced 13 GHz of bandwidth and 5.5 dB gain. Instead of wide bandwidth and high gain, the proposed antenna is capable of becoming water resistant by covering its radiator and SMA connector. Such capabilities of the new PDMS-GM antenna indicated suitability for the fifth-generation (5G) wireless communication systems.

  9. Wideband and flat-gain amplifier based on high concentration erbium-doped fibres in parallel double-pass configuration

    SciTech Connect

    Hamida, B A; Cheng, X S; Harun, S W; Naji, A W; Arof, H; Al-Khateeb, W; Khan, S; Ahmad, H

    2012-03-31

    A wideband and flat gain erbium-doped fibre amplifier (EDFA) is demonstrated using a hybrid gain medium of a zirconiabased erbium-doped fibre (Zr-EDF) and a high concentration erbium-doped fibre (EDF). The amplifier has two stages comprising a 2-m-long ZEDF and 9-m-long EDF optimised for C- and L-band operations, respectively, in a double-pass parallel configuration. A chirp fibre Bragg grating (CFBG) is used in both stages to ensure double propagation of the signal and thus to increase the attainable gain in both C- and L-band regions. At an input signal power of 0 dBm, a flat gain of 15 dB is achieved with a gain variation of less than 0.5 dB within a wide wavelength range from 1530 to 1605 nm. The corresponding noise figure varies from 6.2 to 10.8 dB within this wavelength region.

  10. High sensitivity of spontaneous spike frequency to sodium leak current in a Lymnaea pacemaker neuron.

    PubMed

    Lu, T Z; Kostelecki, W; Sun, C L F; Dong, N; Pérez Velázquez, J L; Feng, Z-P

    2016-12-01

    The spontaneous rhythmic firing of action potentials in pacemaker neurons depends on the biophysical properties of voltage-gated ion channels and background leak currents. The background leak current includes a large K(+) and a small Na(+) component. We previously reported that a Na(+) -leak current via U-type channels is required to generate spontaneous action potential firing in the identified respiratory pacemaker neuron, RPeD1, in the freshwater pond snail Lymnaea stagnalis. We further investigated the functional significance of the background Na(+) current in rhythmic spiking of RPeD1 neurons. Whole-cell patch-clamp recording and computational modeling approaches were carried out in isolated RPeD1 neurons. The whole-cell current of the major ion channel components in RPeD1 neurons were characterized, and a conductance-based computational model of the rhythmic pacemaker activity was simulated with the experimental measurements. We found that the spiking rate is more sensitive to changes in the Na(+) leak current as compared to the K(+) leak current, suggesting a robust function of Na(+) leak current in regulating spontaneous neuronal firing activity. Our study provides new insight into our current understanding of the role of Na(+) leak current in intrinsic properties of pacemaker neurons.

  11. Energy Gain in Collisions of Highly Charged Ions with C_60

    NASA Astrophysics Data System (ADS)

    Thumm, Uwe; Bárány, Anders; Cederquist, Henrik

    1997-04-01

    Within the dynamical classical over--barrier model for charge transfer in soft ion--cluster collisions [1], we have simulated [2] the kinetic energy gain Q of 3.3 q keV Ar^q+ ions in collisions with neutral C_60 targets. Our semi--classical theory allows for the calculation of Q in two different ways, either as difference of electronic binding energies before and after the collision or by integrating the dynamically changing force between the collision partners along the trajectory. A comparison between the two ways provides an intrinsic test of the model calculation. Comparison with recent experimental data [3] shows good agreement in the main features of the energy gain spectra and facilitates their interpretation in terms of the number and final states of transferred electrons. [1] U. Thumm, J. Phys. B27 3515 (1994); Phys. Rev. A55 (Jan.1997). [2] U. Thumm, A. Bárány and H. Cederquist, to be published. [3] N. Selberg et al., Phys. Rev. A 53, 874 (1996). description U.T. is supported by the Division of Chemical Sciences, Basis Energy Sciences, Office of Energy Research, U.S. Department of Energy.

  12. Attentional bias toward high-calorie food-cues and trait motor impulsivity interactively predict weight gain

    PubMed Central

    Meule, Adrian; Platte, Petra

    2016-01-01

    Strong bottom-up impulses and weak top-down control may interactively lead to overeating and, consequently, weight gain. In the present study, female university freshmen were tested at the start of the first semester and again at the start of the second semester. Attentional bias toward high- or low-calorie food-cues was assessed using a dot-probe paradigm and participants completed the Barratt Impulsiveness Scale. Attentional bias and motor impulsivity interactively predicted change in body mass index: motor impulsivity positively predicted weight gain only when participants showed an attentional bias toward high-calorie food-cues. Attentional and non-planning impulsivity were unrelated to weight change. Results support findings showing that weight gain is prospectively predicted by a combination of weak top-down control (i.e. high impulsivity) and strong bottom-up impulses (i.e. high automatic motivational drive toward high-calorie food stimuli). They also highlight the fact that only specific aspects of impulsivity are relevant in eating and weight regulation. PMID:28070402

  13. Attentional bias toward high-calorie food-cues and trait motor impulsivity interactively predict weight gain.

    PubMed

    Meule, Adrian; Platte, Petra

    2016-01-01

    Strong bottom-up impulses and weak top-down control may interactively lead to overeating and, consequently, weight gain. In the present study, female university freshmen were tested at the start of the first semester and again at the start of the second semester. Attentional bias toward high- or low-calorie food-cues was assessed using a dot-probe paradigm and participants completed the Barratt Impulsiveness Scale. Attentional bias and motor impulsivity interactively predicted change in body mass index: motor impulsivity positively predicted weight gain only when participants showed an attentional bias toward high-calorie food-cues. Attentional and non-planning impulsivity were unrelated to weight change. Results support findings showing that weight gain is prospectively predicted by a combination of weak top-down control (i.e. high impulsivity) and strong bottom-up impulses (i.e. high automatic motivational drive toward high-calorie food stimuli). They also highlight the fact that only specific aspects of impulsivity are relevant in eating and weight regulation.

  14. Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulisification as an alternative to ultrasonic and high-shear devices.

    PubMed

    François, Ganachaud; Katz, Joseph L

    2005-02-01

    The preparation of polymeric particles and capsules by means of spontaneous droplet formation and subsequent polymer precipitation or synthesis is well-known. However, spontaneous emulsification is a phenomenon that has often been erroneously interpreted. This Minireview provides new insights into the preparation of metastable liquid dispersions by homogeneous liquid-liquid nucleation, and is based primarily on a recent study by Vitale and Katz (Langmuir, 2003, 19, 4105-4110). This spontaneous emulsification, which they named the Ouzo effect, occurs upon pouring, into water, a mixture of a totally water-miscible solvent and a hydrophobic oil--and optionally some water--thus generating long-lived small droplets, which are formed even though no surfactant is present. Herein, we review and reinterpret the most relevant publications on the synthesis of a variety of dispersions (pseudolatexes, silicone emulsions, biodegradable polymeric nanocapsules, etc.), which we believe have actually been synthesized using the Ouzo effect. The Ouzo effect may also become a substitute for high-shear techniques, which, to date have only been of limited utility on industrial scales.

  15. High Efficiency Automatic-Power-Controlled and Gain-Clamped EDFA for Broadband Passive Optical Networking Systems

    NASA Astrophysics Data System (ADS)

    Shen, Jyi-Lai; Wei, Shui-Ken; Lin, Chin-Yuan; Iong Li, Ssu; Huang, Chih-Chuan

    2010-04-01

    The configuration of a simple improved high efficiency automatic-power-controlled and gain-clamped EDFA (APC-GC-EDFA) for broadband passive optical networking systems (BPON) is presented here. In order to compensate the phase and amplitude variation due to the different distance between the optical line terminal (OLT) and optical network units (ONU), the APC-GC-EDFA need to be employed. A single 980 nm laser module is employed as the primary pump. To extend the bandwidth, all C-band ASE is recycled as the secondary pump to enhance the gain efficiency. An electrical feedback circuit is used as a multi-wavelength channel transmitter monitor for the automatic power control to improve the gain-flattened flatness for stable amplification. The experimental results prove that the EDFA system can provide flatter clamped gain in both C-band and L-band configurations. The gain flatness wavelength ranging from 1530 to 1610 nm is within 32.83 ± 0.64 dB, i.e. below 1.95 %. The gains are clamped at 33.85 ± 0.65 dB for the input signal power of -40 dBm to -10 dBm. The range of noise figure is between 6.37 and 6.56, which is slightly lower compared to that of unclamped amplifiers. This will be very useful for measuring the gain flatness of APC-GC-EDFA. Finally, we have also demonstrated the records of the overall simultaneous dynamics measurements for the new system stabilization. The carrier to noise ratio (CNR) is 49.5 to 50.8 dBc which is above the National Television System Committee (NTSC) standard of 43 dBc, and both composite second order (CSO) 69.2 to 71.5 dBc and composite triple beat (CTB) of 69.8 to 72.2 dBc are above 53 dBc. The recorded corresponding rise-time of 1.087 ms indicates that the system does not exhibit any overshoot of gain or ASE variation due to the signal at the beginning of the pulse.

  16. High-gain step-profiled integrated diagonal horn-antennas

    NASA Astrophysics Data System (ADS)

    Eleftheriades, George V.; Rebeiz, Gabriel M.

    1992-05-01

    A new step-profiled integrated-horn antenna is proposed. The antenna allows gains in the range of 17-20 dB to be achieved using standard (100) silicon wafers. The antenna is diagonally fed and exhibits very good circular symmetry within the 10-dB beamwidth. It has a fundamental Gaussian coupling efficiency of 83 percent. It is demonstrated that the profiled antenna has a radiation pattern similar to that of its smooth envelope horn, provided that the discontinuity between successive wafers does not exceed 0.15 lambda. The integrated stepped-profile horn performs much better than a corresponding smooth 70 deg flare-angle integrated horn of the same aperture size. The integrated step-profile horn is very well-suited for radio-astonomical and remote-sensing millimeter-wave imaging arrays requiring a large number of focal-plane elements.

  17. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet.

    PubMed

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In; Park, Sang-Joon; Lee, Sang Gyu; Lee, Inkyu; Kim, Myoung Ok; Yoon, Duhak; Ryoo, Zae Young

    2014-02-14

    Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1's role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

  18. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats

    PubMed Central

    Kelly, Karen B.; Kennelly, John P.; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J.; Jacobs, René L.

    2016-01-01

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p < 0.05). Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor γ (PPARγ) and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p < 0.05). In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet. PMID:27669293

  19. Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats.

    PubMed

    Kelly, Karen B; Kennelly, John P; Ordonez, Marta; Nelson, Randal; Leonard, Kelly; Stabler, Sally; Gomez-Muñoz, Antonio; Field, Catherine J; Jacobs, René L

    2016-09-23

    Folic acid intake has increased to high levels in many countries, raising concerns about possible adverse effects, including disturbances to energy and lipid metabolism. Our aim was to investigate the effects of excess folic acid (EFA) intake compared to adequate folic acid (AFA) intake on metabolic health in a rodent model. We conducted these investigations in the setting of either a 15% energy low fat (LF) diet or 60% energy high fat (HF) diet. There was no difference in weight gain, fat mass, or glucose tolerance in EFA-fed rats compared to AFA-fed rats when they were fed a LF diet. However, rats fed EFA in combination with a HF diet had significantly greater weight gain and fat mass compared to rats fed AFA (p < 0.05). Gene expression analysis showed increased mRNA levels of peroxisome proliferator-activated receptor γ (PPARγ) and some of its target genes in adipose tissue of high fat-excess folic acid (HF-EFA) fed rats. Inflammation was increased in HF-EFA fed rats, associated with impaired glucose tolerance compared to high fat-adequate folic acid (HF-AFA) fed rats (p < 0.05). In addition, folic acid induced PPARγ expression and triglyceride accumulation in 3T3-L1 cells. Our results suggest that excess folic acid may exacerbate weight gain, fat accumulation, and inflammation caused by consumption of a HF diet.

  20. A multifunctional switched-capacitor programmable gain amplifier for high-definition video analog front-ends

    NASA Astrophysics Data System (ADS)

    Hong, Zhang; Jie, Zhang; Mudan, Zhang; Xue, Li; Jun, Cheng

    2015-03-01

    A multifunctional programmable gain amplifier (PGA) that provides gain and offset adjusting abilities for high-definition video analog front-ends (AFE) is presented. With a switched-capacitor structure, the PGA also acts as a sample and holder of the analog-to-digital converter (ADC) in the AFE to reduce the power consumption and chip area of the whole AFE. Furthermore, the PGA converts the single-ended video signal into differential signal for the following ADC to reject common-mode noise and interferences. The 9-bit digital-to-analog converter (DAC) for gain and offset adjusting is embedded into the switched capacitor networks of the PGA. A video AFE integrated circuit based on the proposed PGA is fabricated in a 0.18-μm process. Simulation and measurement results show that the PGA achieves a gain control range of 0.90 to 2.34 and an offset control range of -220 to 220 mV while consuming 10.1 mA from a 1.8 V power supply. Project supported by the National Natural Science Foundation of China (No. 61106027), and the Science and Technology Project of Shanxi Province (No. 2014K05-14).

  1. Thermal lens shaping in Brewster gain media: A high-power, diode-pumped Nd:GdVO(4) laser.

    PubMed

    Rimington, N; Schieffer, S; Schroeder, W; Brickeen, Brian

    2004-04-05

    A straightforward method is presented for generating a stigmatic spherical thermal lens in laser-diode-pumped, Brewster-cut solid-state gain media by shaping the aspect ratio of the elliptical pumped region. Demonstration of this laser head design with Nd:GdVO(4) as the gain medium yields a stable, efficient, high-power (>20W) diode-pumped laser at 1063nm. Analysis of the spatial mode characteristics of a 67cm-long symmetric resonator both confirms the radially symmetric nature of the pump-induced thermal lens and indicates that laser resonators incorporating this head design can readily generate a high spatial beam quality (M(2) < 2).

  2. High magnetic shear gain in a liquid sodium stable couette flow experiment A prelude to an alpha - omega dynamo

    SciTech Connect

    Colgate, Stirling; Li, Jui; Finn, John; Pariev, Vladimir; Beckley, Howard; Si, Jiahe; Martinic, Joe; Westpfahl, David; Slutz, James; Westrom, Zeb; Klein, Brianna

    2010-11-08

    The {Omega}-phase of the liquid sodium {alpha}-{Omega} dynamo experiment at NMIMT in cooperation with LANL has successfully demonstrated the production of a high toroidal field, B{sub {phi}} {approx_equal} 8 x B{sub r} from the radial component of an applied poloidal magnetic field, B{sub r}. This enhanced toroidal field is produced by rotational shear in stable Couette Row within liquid sodium at Rm {approx_equal} 120. The small turbulence in stable Taylor-Couette Row is caused by Ekman Row where ({delta}v/v){sup 2} {approx} 10{sup -3}. This high {Omega}-gain in low turbulence flow contrasts with a smaller {Omega}-gain in higher turbulence, Helmholtz-unstable shear flows. This result supports the ansatz that large scale astrophysical magnetic fields are created within semi-coherent large scale motions in which turbulence plays a diffusive role that enables magnetic flux linkage.

  3. Optically pumped NH[sub 3] as a high-gain amplifier for CO[sub 2] laser radiation

    SciTech Connect

    White, J.D. . Dept. of Engineering Physics); Reid, J. )

    1993-01-01

    Optically pumped high-pressure mixtures of NH[sub 3] in N[sub 2] are shown to be efficient broad-band amplifiers of pulsed CO[sub 2] radiation. In a dilute NH[sub 3] mixture at 6 atm a single-pass gain of 150 (21.8 dB) was measured for the 10P (34) CO[sub 2] transition. Gain was observed in NH[sub 3] at pressures as high as 10 atm. Experimental measurements were made for a range of wavelengths in the 10.7 [mu]m region, and the results compared with calculations based on a rate-equation model.

  4. Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.

    PubMed

    Ugleholdt, Randi; Pedersen, Jens; Bassi, Maria Rosaria; Füchtbauer, Ernst-Martin; Jørgensen, Signe Marie; Kissow, Hanne-Louise; Nytofte, Nikolaj; Poulsen, Steen Seier; Rosenkilde, Mette Marie; Seino, Yutaka; Thams, Peter; Holst, Peter Johannes; Holst, Jens Juul

    2011-12-30

    The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. To independently investigate the contribution of the insulinotropic effects and the direct effects on adipose tissue, we generated transgenic mice with targeted expression of the human GIPr to white adipose tissue or beta-cells, respectively. These mice were then cross-bred with the GIPr knock-out strain. The central findings of the study are that mice with GIPr expression targeted to adipose tissue have a similar high fat diet -induced body weight gain as control mice, significantly greater than the weight gain in mice with a general ablation of the receptor. Surprisingly, this difference was due to an increase in total lean body mass rather than a gain in total fat mass that was similar between the groups. In contrast, glucose-dependent insulinotropic polypeptide-mediated insulin secretion does not seem to be important for regulation of body weight after high fat feeding. The study supports a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis.

  5. High-gain and low-excess noise near-infrared single-photon avalanche detector arrays

    NASA Astrophysics Data System (ADS)

    Linga, Krishna; Yevtukhov, Yuriy; Liang, Bing

    2010-04-01

    We have designed and developed a new family of photodetectors and arrays with Internal Discrete Amplification (IDA) mechanism for the realization of very high gain and low excess noise factor in the visible and near infrared spectral regions. These devices surpass many limitations of the Single Photon Avalanche Photodetectors such as ultra low excess noise factor, very high gain, lower reset time (< 200 ns). These devices are very simple to operate in the non-gated mode under a constant dc bias voltage. Because of its unique characteristics of self-quenching and self-recovery, no external quenching circuit is needed. This unique feature of self quenching and self-recovery makes it simple to less complex readout integrated circuit to realize large format detector arrays. In this paper, we present the discrete amplification design approach used for the development of self reset, high gain photodetector arrays in the near infrared wavelength region. The demonstrated device performance far exceeds any available solid state Photodetectors in the near infrared wavelength range. These devices are ideal for researchers in the field of spectroscopy, industrial and scientific instrumentation, Ladar, quantum cryptography, night vision and other military, defense and aerospace applications.

  6. On the Fielding of a High Gain, Shock-Ignited Target on the National Ignitiion Facility in the Near Term

    SciTech Connect

    Perkins, L J; Betti, R; Schurtz, G P; Craxton, R S; Dunne, A M; LaFortune, K N; Schmitt, A J; McKenty, P W; Bailey, D S; Lambert, M A; Ribeyre, X; Theobald, W R; Strozzi, D J; Harding, D R; Casner, A; Atzemi, S; Erbert, G V; Andersen, K S; Murakami, M; Comley, A J; Cook, R C; Stephens, R B

    2010-04-12

    Shock ignition, a new concept for igniting thermonuclear fuel, offers the possibility for a near-term ({approx}3-4 years) test of high gain inertial confinement fusion on the National Ignition Facility at less than 1MJ drive energy and without the need for new laser hardware. In shock ignition, compressed fusion fuel is separately ignited by a strong spherically converging shock and, because capsule implosion velocities are significantly lower than those required for conventional hotpot ignition, fusion energy gains of {approx}60 may be achievable on NIF at laser drive energies around {approx}0.5MJ. Because of the simple all-DT target design, its in-flight robustness, the potential need for only 1D SSD beam smoothing, minimal early time LPI preheat, and use of present (indirect drive) laser hardware, this target may be easier to field on NIF than a conventional (polar) direct drive hotspot ignition target. Like fast ignition, shock ignition has the potential for high fusion yields at low drive energy, but requires only a single laser with less demanding timing and spatial focusing requirements. Of course, conventional symmetry and stability constraints still apply. In this paper we present initial target performance simulations, delineate the critical issues and describe the immediate-term R&D program that must be performed in order to test the potential of a high gain shock ignition target on NIF in the near term.

  7. Bremsstrahlung emission of high energy accompanying spontaneous fission of {sup 252}Cf

    SciTech Connect

    Maydanyuk, S. P.; Olkhovsky, V. S.; Mandaglio, G.; Manganaro, M.; Fazio, G.; Giardina, G.

    2010-07-15

    The study of the bremsstrahlung photon emission accompanying fragments produced in the spontaneous fission of heavy nuclei by a fully quantum approach is presented for the first time. This kind of problem requires the knowledge of wave functions of the fissioning system leading to a wide distribution of couples of fragments that are the products of fission. With the aim of obtaining these wave functions, the interaction potential between the emitted fragment and residual nucleus is calculated by a standard approach. A new procedure was performed that allows an increase in the accuracy of calculations of radial integrals in the far asymptotic region and the achievement of the convenient convergence in calculations of the spectra. The total probability of the emitted photons in the spontaneous fission of {sup 252}Cf was calculated in such a way. We obtained good agreement between theory and experimental data up to 38 MeV for the bremsstrahlung spectrum of photons while the calculation of the total probability of photon emission accompanying fragments was performed up to an energy of 60 MeV. The analysis of contributions in the bremsstrahlung spectrum accompanying the emission of light, medium, and heavy fragments in the fission of {sup 252}Cf is presented.

  8. Dynamic receptor team formation can explain the high signal transduction gain in Escherichia coli.

    PubMed

    Albert, Réka; Chiu, Yu-Wen; Othmer, Hans G

    2004-05-01

    Evolution has provided many organisms with sophisticated sensory systems that enable them to respond to signals in their environment. The response frequently involves alteration in the pattern of movement, either by directed movement, a process called taxis, or by altering the speed or frequency of turning, which is called kinesis. Chemokinesis has been most thoroughly studied in the peritrichous bacterium Escherichia coli, which has four helical flagella distributed over the cell surface, and swims by rotating them. When rotated counterclockwise the flagella coalesce into a propulsive bundle, producing a relatively straight "run," and when rotated clockwise they fly apart, resulting in a "tumble" which reorients the cell with little translocation. A stochastic process generates the runs and tumbles, and in a chemoeffector gradient, runs that carry the cell in a favorable direction are extended. The cell senses spatial gradients as temporal changes in receptor occupancy and changes the probability of counterclockwise rotation (the bias) on a fast timescale, but adaptation returns the bias to baseline on a slow timescale, enabling the cell to detect and respond to further concentration changes. The overall structure of the signal transduction pathways is well characterized in E. coli, but important details are still not understood. Only recently has a source of gain in the signal transduction network been identified experimentally, and here we present a mathematical model based on dynamic assembly of receptor teams that can explain this observation.

  9. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

    SciTech Connect

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In; Park, Sang-Joon; Lee, Sang Gyu; Lee, Inkyu; Kim, Myoung Ok; Yoon, Duhak; Ryoo, Zae Young

    2014-02-14

    Highlights: • The expression of Jazf1 in the liver suppressed lipid accumulation. • Jazf1 significantly increases transcription of fatty acid synthase. • Jazf1 plays a critical role in the regulation of energy and lipid homeostasis. • Jazf1 associates the development of metabolic disorder. • Jazf1 may provide a new therapeutic target in the management of metabolic disorder. - Abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1’s role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

  10. Dynamic Receptor Team Formation Can Explain the High Signal Transduction Gain in Escherichia coli

    PubMed Central

    Albert, Réka; Chiu, Yu-wen; Othmer, Hans G.

    2004-01-01

    Evolution has provided many organisms with sophisticated sensory systems that enable them to respond to signals in their environment. The response frequently involves alteration in the pattern of movement, either by directed movement, a process called taxis, or by altering the speed or frequency of turning, which is called kinesis. Chemokinesis has been most thoroughly studied in the peritrichous bacterium Escherichia coli, which has four helical flagella distributed over the cell surface, and swims by rotating them. When rotated counterclockwise the flagella coalesce into a propulsive bundle, producing a relatively straight “run,” and when rotated clockwise they fly apart, resulting in a “tumble” which reorients the cell with little translocation. A stochastic process generates the runs and tumbles, and in a chemoeffector gradient, runs that carry the cell in a favorable direction are extended. The cell senses spatial gradients as temporal changes in receptor occupancy and changes the probability of counterclockwise rotation (the bias) on a fast timescale, but adaptation returns the bias to baseline on a slow timescale, enabling the cell to detect and respond to further concentration changes. The overall structure of the signal transduction pathways is well characterized in E. coli, but important details are still not understood. Only recently has a source of gain in the signal transduction network been identified experimentally, and here we present a mathematical model based on dynamic assembly of receptor teams that can explain this observation. PMID:15111386

  11. Very High Energy Gain at the Neptune Inverse Free Electron Laser Experiment

    SciTech Connect

    Musumeci, P.; Boucher, S.; Doyuran, A.; England, R. J.; Pellegrini, C.; Rosenzweig, J. B.; Travish, G.; Yoder, R.; Tochitsky, S.Ya.; Joshi, C.; Ralph, J.; Sung, C.; Tolmachev, S.; Varfolomeev, A.; Varfolomeev, A. Jr.; Yarovoi, T.

    2004-12-07

    We report the observation of energy gain in excess of 20 MeV at the Inverse Free Electron Laser Accelerator experiment at the Neptune Laboratory at UCLA. A 14.5 MeV electron beam is injected in an undulator strongly tapered in period and field amplitude. The IFEL driver is a CO2 10.6 {mu}m laser with power larger than 400 GW. The Rayleigh range of the laser, {approx} 1.8 cm, is much shorter than the undulator length so that the interaction is diffraction dominated. A few per cent of the injected particles are trapped in a stable accelerating bucket. Electrons with energies up to 35 MeV are measured by a magnetic spectrometer. Three-dimensional simulations, in good agreement with the measured electron energy spectrum, indicate that most of the acceleration occurs in the first 25 cm of the undulator, corresponding to an energy gradient larger than 70 MeV/m. The measured energy spectrum also indicates that higher harmonic Inverse Free Electron Laser interaction takes place in the second section of the undulator.

  12. High-gain cryogenic amplifier assembly employing a commercial CMOS operational amplifier.

    PubMed

    Proctor, J E; Smith, A W; Jung, T M; Woods, S I

    2015-07-01

    We have developed a cryogenic amplifier for the measurement of small current signals (10 fA-100 nA) from cryogenic optical detectors. Typically operated with gain near 10(7) V/A, the amplifier performs well from DC to greater than 30 kHz and exhibits noise level near the Johnson limit. Care has been taken in the design and materials to control heat flow and temperatures throughout the entire detector-amplifier assembly. A simple one-board version of the amplifier assembly dissipates 8 mW to our detector cryostat cold stage, and a two-board version can dissipate as little as 17 μW to the detector cold stage. With current noise baseline of about 10 fA/(Hz)(1/2), the cryogenic amplifier is generally useful for cooled infrared detectors, and using blocked impurity band detectors operated at 10 K, the amplifier enables noise power levels of 2.5 fW/(Hz)(1/2) for detection of optical wavelengths near 10 μm.

  13. A practical technique for measuring human biofluid conductivity using high gain-frequency characteristics.

    PubMed

    Al-Nabulsi, Jamal I; Aloquili, Osama; Ausheva, Vektoria; Yuldashev, Zafar M

    2011-11-01

    Currently, the study of ion composition and performance in human biofluids plays an important role in biomedical engineering research and technology. This field may become universal for human diagnostics; it allows early detection of different diseases in humans by measuring changes in ion behaviour in human biofluids. Practical experiments were conducted to analyse the liquid composite electrolyte conductivity in an alternating electric current field. These experiments allow the contribution of separate types of ions to the overall conductivity to be estimated. The method of estimating the concentration of active ions contained in biofluids is also introduced; it illustrates the possibility of performing qualitative and quantitative analysis over a wide range of concentrations and compositions. The authors present a procedure to determine the concentration of active liquid ions based on conductivity gain-frequency characteristic curve tracing. The experimental results validate the practical use of the proposed method. The results of this research are promising, and further investigation is required to further improve the method.

  14. Regrowth-free high-gain InGaAsP/InP active-passive platform via ion implantation.

    PubMed

    Parker, John S; Sivananthan, Abirami; Norberg, Erik; Coldren, Larry A

    2012-08-27

    We demonstrate a regrowth-free material platform to create monolithic InGaAsP/InP photonic integrated circuits (PICs) with high-gain active and low-loss passive sections via a PL detuning of >135 nm. We show 2.5 µm wide by 400 µm long semiconductor optical amplifiers with >40 dB/mm gain at 1570 nm, and passive waveguide losses <2.3 dB/mm. The bandgap in the passive section is detuned using low-energy 190 keV channelized phosphorous implantation and subsequent rapid thermal annealing to achieve impurity-induced quantum well intermixing (QWI). The PL wavelengths in the active and passive sections are 1553 and 1417 nm, respectively. Lasing wavelengths for 500 µm Fabry-Perot lasers are 1567 and 1453 nm, respectively.

  15. Spontaneous Fission

    DOE R&D Accomplishments Database

    Segre, Emilio

    1950-11-22

    The first attempt to discover spontaneous fission in uranium was made by [Willard] Libby, who, however, failed to detect it on account of the smallness of effect. In 1940, [K. A.] Petrzhak and [G. N.] Flerov, using more sensitive methods, discovered spontaneous fission in uranium and gave some rough estimates of the spontaneous fission decay constant of this substance. Subsequently, extensive experimental work on the subject has been performed by several investigators and will be quoted in the various sections. [N.] Bohr and [A.] Wheeler have given a theory of the effect based on the usual ideas of penetration of potential barriers. On this project spontaneous fission has been studied for the past several years in an effort to obtain a complete picture of the phenomenon. For this purpose the spontaneous fission decay constants {lambda} have been measured for separated isotopes of the heavy elements wherever possible. Moreover, the number {nu} of neutrons emitted per fission has been measured wherever feasible, and other characteristics of the spontaneous fission process have been studied. This report summarizes the spontaneous fission work done at Los Alamos up to January 1, 1945. A chronological record of the work is contained in the Los Alamos monthly reports.

  16. High Adherence to CPAP Treatment Does Not Prevent the Continuation of Weight Gain among Severely Obese OSAS Patients

    PubMed Central

    Myllylä, Minna; Kurki, Samu; Anttalainen, Ulla; Saaresranta, Tarja; Laitinen, Tarja

    2016-01-01

    Study Objectives: Obstructive sleep apnea syndrome (OSAS) patients benefit from continuous positive airway pressure (CPAP) treatment in a dose-response manner. We determined adherence and weight control, as well as their predictors, among long-term CPAP users. Methods: Cohort of 1,023 OSAS patients had used CPAP on average of 6.6 ± 1.2 years. BMI was determined at baseline and at follow-up visits. There were 7.4 ± 1.7 BMI and 6.5 ± 1.8 CPAP usage measurements per patient on average. Using the Bayesian hierarchical model, we determined the patients' individual trends of BMI and adherence development. Patients with significantly increasing or decreasing trends were identified at the posterior probability level of > 90%. Results: The mean age in the cohort was 55.6 ± 9.8 years, BMI 33.5 ± 6.4 kg/m2, apnea-hypopnea index 33.7 ± 23.1, and CPAP usage 6.0 ± 1.8 h/day. The majority of patients had no significant change in BMI (mean annual weight gain 0.04 ± 0.29 kg/m2) or CPAP adherence (mean annual increase 11.4 ± 7.0 min/day). However, at the individual level, 10% of the patients showed significant annual weight gain (0.63 ± 0.35 kg/m2) during the 5-year follow-up period. At baseline these patients were already more severely obese (mean BMI 40.0 ± 5.9 kg/m2) despite being younger (mean 50.9 ± 9.5 years) than the rest of the cohort. Conclusions: In the majority of CPAP-treated OSAS patients, weight did not significantly change but gained slightly slower than in age-matched population in general. However, in 10% of patients, high adherence to CPAP treatment did not prevent the continuation of weight gain. These patients present a high-risk group for OSAS-related multimorbidity later in life. Citation: Myllylä M, Kurki S, Anttalainen U, Saaresranta T, Laitinen T. High adherence to CPAP treatment does not prevent the continuation of weight gain among severely obese OSAS patients. J Clin Sleep Med 2016;12(4):519–528. PMID:26888588

  17. Development of high damage threshold laser-machined apodizers and gain filters for laser applications

    DOE PAGES

    Rambo, Patrick; Schwarz, Jens; Kimmel, Mark; ...

    2016-09-27

    We have developed high damage threshold filters to modify the spatial profile of a high energy laser beam. The filters are formed by laser ablation of a transmissive window. The ablation sites constitute scattering centers which can be filtered in a subsequent spatial filter. Finally, by creating the filters in dielectric materials, we see an increased laser-induced damage threshold from previous filters created using ‘metal on glass’ lithography.

  18. Multifunctional Polymer Nanofibers: UV Emission, Optical Gain, Anisotropic Wetting, and High Hydrophobicity for Next Flexible Excitation Sources.

    PubMed

    Morello, Giovanni; Manco, Rita; Moffa, Maria; Persano, Luana; Camposeo, Andrea; Pisignano, Dario

    2015-10-07

    The use of UV light sources is highly relevant in many fields of science, being directly related to all those detection and diagnosis procedures that are based on fluorescence spectroscopy. Depending on the specific application, UV light-emitting materials are desired to feature a number of opto-mechanical properties, including brightness, optical gain for being used in laser devices, flexibility to conform with different lab-on-chip architectures, and tailorable wettability to control and minimize their interaction with ambient humidity and fluids. In this work, we introduce multifunctional, UV-emitting electrospun fibers with both optical gain and greatly enhanced anisotropic hydrophobicity compared to films. Fibers are described by the onset of a composite wetting state, and their arrangement in uniaxial arrays further favors liquid directional control. The low gain threshold, optical losses, plastic nature, flexibility, and stability of these UV-emitting fibers make them interesting for building light-emitting devices and microlasers. Furthermore, the anisotropic hydrophobicity found is strongly synergic with optical properties, reducing interfacial interactions with liquids and enabling smart functional surfaces for droplet microfluidic and wearable applications.

  19. Multifunctional Polymer Nanofibers: UV Emission, Optical Gain, Anisotropic Wetting, and High Hydrophobicity for Next Flexible Excitation Sources

    PubMed Central

    2015-01-01

    The use of UV light sources is highly relevant in many fields of science, being directly related to all those detection and diagnosis procedures that are based on fluorescence spectroscopy. Depending on the specific application, UV light-emitting materials are desired to feature a number of opto-mechanical properties, including brightness, optical gain for being used in laser devices, flexibility to conform with different lab-on-chip architectures, and tailorable wettability to control and minimize their interaction with ambient humidity and fluids. In this work, we introduce multifunctional, UV-emitting electrospun fibers with both optical gain and greatly enhanced anisotropic hydrophobicity compared to films. Fibers are described by the onset of a composite wetting state, and their arrangement in uniaxial arrays further favors liquid directional control. The low gain threshold, optical losses, plastic nature, flexibility, and stability of these UV-emitting fibers make them interesting for building light-emitting devices and microlasers. Furthermore, the anisotropic hydrophobicity found is strongly synergic with optical properties, reducing interfacial interactions with liquids and enabling smart functional surfaces for droplet microfluidic and wearable applications. PMID:26401889

  20. General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.

    PubMed

    Swithers, Susan E; Baker, Chelsea R; Davidson, T L

    2009-08-01

    In an earlier work (S. E. Swithers & T. L. Davidson, 2008), rats provided with a fixed amount of a yogurt diet mixed with saccharin gained more weight and showed impaired caloric compensation relative to rats given the same amount of yogurt mixed with glucose. The present 4 experiments examined the generality of these findings and demonstrated that increased body weight gain was also demonstrated when animals consumed a yogurt diet sweetened with an alternative high-intensity sweetener (acesulfame potassium; AceK) as well as in animals given a saccharin-sweetened base diet (refried beans) that was calorically similar but nutritionally distinct from low-fat yogurt. These studies also extended earlier findings by showing that body weight differences persist after saccharin-sweetened diets are discontinued and following a shift to a diet sweetened with glucose. In addition, rats first exposed to a diet sweetened with glucose still gain additional weight when subsequently exposed to a saccharin-sweetened diet. The results of these experiments add support to the hypothesis that exposure to weak or nonpredictive relationships between sweet tastes and caloric consequences may lead to positive energy balance.

  1. Analog time-reversed ultrasonically encoded (TRUE) optical focusing inside scattering media with high power gain (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Ma, Cheng; Xu, Xiao; Wang, Lihong V.

    2016-03-01

    Focusing light deep inside scattering media plays a key role in such biomedical applications as high resolution optical imaging, control, and therapy. In recent years, wavefront shaping technologies have come a long way in controlling light propagation in complex media. A prominent example is time-reversed ultrasonically encoded (TRUE) focusing, which allows noninvasive introduction of "guide stars" inside biological tissue to guide light focusing. By measuring the optical wavefront emanating from an ultrasound focus created at the target location, TRUE determines the desired wavefront non-iteratively, and achieves focusing at the target position via a subsequent optical time reversal. Compared to digital counterparts that employ slow electronic spatial light modulators and cameras, analog TRUE focusing relies on nonlinear photorefractive crystals that inherently accommodate more spatial modes and eliminate the troublesome alignment and data transfer required by digital approaches. However, analog TRUE focusing suffers from its small gain, defined as the energy or power ratio between the focusing and probing beams in the focal volume. Here, by implementing a modified analog TRUE focusing scheme that squeezes the duration of the time-reversed photon packet below the carrier-recombination-limited hologram decay time of the crystal, we demonstrated a photon flux amplification much greater than unity at a preset focal voxel in between two scattering layers. Although the energy gain was still below unity, the unprecedented power gain will nevertheless benefit new biomedical applications.

  2. Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats.

    PubMed

    Koriyama, Hiroshi; Nakagami, Hironori; Nakagami, Futoshi; Osako, Mariana Kiomy; Kyutoku, Mariko; Shimamura, Munehisa; Kurinami, Hitomi; Katsuya, Tomohiro; Rakugi, Hiromi; Morishita, Ryuichi

    2015-07-01

    Recent research on vaccination has extended its scope from infectious diseases to chronic diseases, including Alzheimer disease, dyslipidemia, and hypertension. The aim of this study was to design DNA vaccines for high blood pressure and eventually develop human vaccine therapy to treat hypertension. Plasmid vector encoding hepatitis B core-angiotensin II (Ang II) fusion protein was injected into spontaneously hypertensive rats using needleless injection system. Anti-Ang II antibody was successfully produced in hepatitis B core-Ang II group, and antibody response against Ang II was sustained for at least 6 months. Systolic blood pressure was consistently lower in hepatitis B core-Ang II group after immunization, whereas blood pressure reduction was continued for at least 6 months. Perivascular fibrosis in heart tissue was also significantly decreased in hepatitis B core-Ang II group. Survival rate was significantly improved in hepatitis B core-Ang II group. This study demonstrated that Ang II DNA vaccine to spontaneously hypertensive rats significantly lowered high blood pressure for at least 6 months. In addition, Ang II DNA vaccines induced an adequate humoral immune response while avoiding the activation of self-reactive T cells, assessed by ELISPOT assay. Future development of DNA vaccine to treat hypertension may provide a new therapeutic option to treat hypertension.

  3. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice

    PubMed Central

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students. Participants were divided into three groups according to their SPAI scores. The upper third (69 or higher), middle third (from 61 to 68) and lower third (60 or lower) of scores were defined as high smartphone users, medium users and low users, respectively. We compared the percentage of small immediate reward/penalty choices in different conditions between the three groups. Relative to the low users group, high users and medium users were more inclined to request an immediate monetary reward. Moreover, for the two dimensions of time and money in intertemporal choice, high users and medium users showed a bias in intertemporal choice task among most of the time points and value magnitude compared to low users. These findings demonstrated that smartphone overuse was associated with problematic decision-making, a pattern similar to that seen in persons affected by a variety of addictions. PMID:28344568

  4. Time Is Money: The Decision Making of Smartphone High Users in Gain and Loss Intertemporal Choice.

    PubMed

    Tang, Zixuan; Zhang, Huijun; Yan, An; Qu, Chen

    2017-01-01

    Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students. Participants were divided into three groups according to their SPAI scores. The upper third (69 or higher), middle third (from 61 to 68) and lower third (60 or lower) of scores were defined as high smartphone users, medium users and low users, respectively. We compared the percentage of small immediate reward/penalty choices in different conditions between the three groups. Relative to the low users group, high users and medium users were more inclined to request an immediate monetary reward. Moreover, for the two dimensions of time and money in intertemporal choice, high users and medium users showed a bias in intertemporal choice task among most of the time points and value magnitude compared to low users. These findings demonstrated that smartphone overuse was associated with problematic decision-making, a pattern similar to that seen in persons affected by a variety of addictions.

  5. Toward the realization of erbium-doped GaN bulk crystals as a gain medium for high energy lasers

    NASA Astrophysics Data System (ADS)

    Sun, Z. Y.; Li, J.; Zhao, W. P.; Lin, J. Y.; Jiang, H. X.

    2016-08-01

    Er-doped GaN (Er:GaN) is a promising candidate as a gain medium for solid-state high energy lasers (HELs) at the technologically important and eye-safe 1.54 μm wavelength window, as GaN has superior thermal properties over traditional laser gain materials such as Nd:YAG. However, the attainment of wafer-scale Er:GaN bulk or quasi-bulk crystals is a prerequisite to realize the full potential of Er:GaN as a gain medium for HELs. We report the realization of freestanding Er:GaN wafers of 2-in. in diameter with a thickness on the millimeter scale. These freestanding wafers were obtained via growth by hydride vapor phase epitaxy in conjunction with a laser-lift-off process. An Er doping level of 1.4 × 1020 atoms/cm3 has been confirmed by secondary ion mass spectrometry measurements. The freestanding Er:GaN wafers exhibit strong photoluminescent emission at 1.54 μm with its emission intensity increasing dramatically with wafer thickness under 980 nm resonant excitation. A low thermal quenching of 10% was measured for the 1.54 μm emission intensity between 10 K and 300 K. This work represents a significant step in providing a practical approach for producing Er:GaN materials with sufficient thicknesses and dimensions to enable the design of gain media in various geometries, allowing for the production of HELs with improved lasing efficiency, atmosphere transmission, and eye-safety.

  6. Purple Sweet Potato Attenuate Weight Gain in High Fat Diet Induced Obese Mice.

    PubMed

    Ju, Ronghui; Zheng, Shujuan; Luo, Hongxia; Wang, Changgang; Duan, Lili; Sheng, Yao; Zhao, Changhui; Xu, Wentao; Huang, Kunlun

    2017-03-01

    Purple sweet potato (PSP) is widely grown in Asia and considered as a healthy vegetable. The objective of the current study was to determine the anti-obesity effect of the PSP on high fat diet induced obese C57BL/6J mice. The mice were administrated with high fat diet supplemented with the sweet potato (SP) or PSP at the concentration of 15% and 30% for 12 wk, respectively. The results showed that the supplementation of SP or PSP at 30% significantly ameliorated high fat diet induced obesity and its associated risk factors, including reduction of body weight and fat accumulation, improvement of lipid profile and modulation of energy expenditure. Moreover, PSP also posed beneficial effect on the liver and kidney functions. These results indicate that PSP and SP have anti-obesity effect and are effective to reduce the metabolic risk.

  7. Shuttle orbiter Ku-band radar/communications system design evaluation: High gain antenna/widebeam horn

    NASA Technical Reports Server (NTRS)

    Iwasaki, R.; Dodds, J. G.; Broad, P.

    1979-01-01

    The physical characteristics of the high gain antenna reflector and feed elements are described. Deficiencies in the sum feed are discussed, and lack of atmospheric venting is posed as a potential problem area. The measured RF performance of the high gain antenna is examined and the high sidelobe levels measured are related to the physical characteristics of the antenna. An examination of the attributes of the feed which might be influenced by temperature extremes shows that the antenna should be insensitive to temperature variations. Because the feed support bipod structure is considered a significant contributor to the high sidelobe levels measured in the azimuth plane, pod relocation, material changes, and shaping are suggested as improvements. Alternate feed designs are presented to further improve system performance. The widebeam horn and potential temperature effects due to the polarizer are discussed as well as in the effects of linear polarization on TDRS acquisition, and the effects of circular polarization on radar sidelobe avoidance. The radar detection probability is analyzed as a function of scan overlap and target range.

  8. Energy gain and spectral tailoring of ion beams using ultra-high intensity laser beams

    NASA Astrophysics Data System (ADS)

    Prasad, Rajendra; Swantusch, Marco; Cerchez, Mirela; Spickermann, Sven; Auorand, Bastian; Wowra, Thomas; Boeker, Juergen; Willi, Oswald

    2015-11-01

    The field of laser driven ion acceleration over the past decade has produced a huge amount of research. Nowadays, several multi-beam facilities with high rep rate system, e.g. ELI, are being developed across the world for different kinds of experiments. The study of interaction dynamics of multiple beams possessing ultra-high intensity and ultra-short pulse duration is of vital importance. Here, we present the first experimental results on ion acceleration using two ultra-high intensity beams. Thanks to the unique capability of Arcturus laser at HHU Düsseldorf, two almost identical, independent beams in laser parameters such as intensity (>1020 W/cm2), pulse duration (30 fs) and contrast (>1010), could be accessed. Both beams are focused onto a 5 μm thin Ti target. While ensuring spatial overlap of the two beams, at relative temporal delay of ~ 50 ps (optimum delay), the proton and carbon ion energies were enhanced by factor of 1.5. Moreover, strong modulation in C4+ions near the high energy cut-off is observed later than the optimum delay for the proton enhancement. This offers controlled tailoring of the spectral content of heavy ions.

  9. The Effects of Three Summer School Programs on the Reading Gains of Junior High School Boys.

    ERIC Educational Resources Information Center

    Duncan, Margaret Haynes

    The purpose of this study was to investigate the comparative efficiency of three summer programs in helping junior high school boys increase their reading ability. The study compared the alternatives of methods typically used in remedial reading programs, a content area program, and one which simply provided personal reinforcement. Each sample…

  10. Characteristics of trap-filled gallium arsenide photoconductive switches used in high gain pulsed power applications

    SciTech Connect

    ISLAM,N.E.; SCHAMILOGLU,E.; MAR,ALAN; LOUBRIEL,GUILLERMO M.; ZUTAVERN,FRED J.; JOSHI,R.P.

    2000-05-30

    The electrical properties of semi-insulating (SI) Gallium Arsenide (GaAs) have been investigated for some time, particularly for its application as a substrate in microelectronics. Of late this material has found a variety of applications other than as an isolation region between devices, or the substrate of an active device. High resistivity SI GaAs is increasingly being used in charged particle detectors and photoconductive semiconductor switches (PCSS). PCSS made from these materials operating in both the linear and non-linear modes have applications such as firing sets, as drivers for lasers, and in high impedance, low current Q-switches or Pockels cells. In the non-linear mode, it has also been used in a system to generate Ultra-Wideband (UWB) High Power Microwaves (HPM). The choice of GaAs over silicon offers the advantage that its material properties allow for fast, repetitive switching action. Furthermore photoconductive switches have advantages over conventional switches such as improved jitter, better impedance matching, compact size, and in some cases, lower laser energy requirement for switching action. The rise time of the PCSS is an important parameter that affects the maximum energy transferred to the load and it depends, in addition to other parameters, on the bias or the average field across the switch. High field operation has been an important goal in PCSS research. Due to surface flashover or premature material breakdown at higher voltages, most PCSS, especially those used in high power operation, need to operate well below the inherent breakdown voltage of the material. The lifetime or the total number of switching operations before breakdown, is another important switch parameter that needs to be considered for operation at high bias conditions. A lifetime of {approximately} 10{sup 4} shots has been reported for PCSS's used in UWB-HPM generation [5], while it has exceeded 10{sup 8} shots for electro-optic drivers. Much effort is currently

  11. Transverse and temporal characteristics of a high-gain free-electron laser in the saturation regime

    NASA Astrophysics Data System (ADS)

    Huang, Zhirong; Kim, Kwang-Je

    2002-05-01

    The transverse and the temporal characteristics of a high-gain free-electron laser are governed by refractive guiding and sideband instability, respectively. Using the self-consistent Vlasov-Maxwell equations, we explicitly determine the effective index of refraction and the guided radiation mode for an electron beam with arbitrary transverse size. Electrons trapped by the guided radiation execute synchrotron oscillation and hence are susceptible to the sideband instability. We explain the spectral evolution and determine the sideband growth rate. These theoretical predictions agree well with GINGER simulation results.

  12. Petawatt laser pulses for proton-boron high gain fusion with avalanche reactions excluding problems of nuclear radiation

    NASA Astrophysics Data System (ADS)

    Hora, Heinrich; Lalousis, Paraskevas; Giuffrida, Lorenzo; Margarone, Daniele; Korn, Georg; Eliezer, Shalom; Miley, George H.; Moustaizis, Stavros; Mourou, Gérard

    2015-05-01

    An alternative way may be possible for igniting solid density hydrogen-11B (HB11) fuel. The use of >petawatt-ps laser pulses from the non-thermal ignition based on ultrahigh acceleration of plasma blocks by the nonlinear (ponderomotive) force, has to be combined with the measured ultrahigh magnetic fields in the 10 kilotesla range for cylindrical trapping. The evaluation of measured alpha particles from HB11 reactions arrives at the conclusion that apart from the usual binary nuclear reactions, secondary reactions by an avalanche multiplication may cause the high gains, even much higher than from deuterium tritium fusion. This may be leading to a concept of clean economic power generation.

  13. Optical cooling and trapping of highly magnetic atoms: the benefits of a spontaneous spin polarization

    NASA Astrophysics Data System (ADS)

    Dreon, Davide; Sidorenkov, Leonid A.; Bouazza, Chayma; Maineult, Wilfried; Dalibard, Jean; Nascimbene, Sylvain

    2017-03-01

    From the study of long-range-interacting systems to the simulation of gauge fields, open-shell lanthanide atoms with their large magnetic moment and narrow optical transitions open novel directions in the field of ultracold quantum gases. As for other atomic species, the magneto-optical trap (MOT) is the working horse of experiments but its operation is challenging, due to the large electronic spin of the atoms. Here we present an experimental study of narrow-line dysprosium MOTs. We show that the combination of radiation pressure and gravitational forces leads to a spontaneous polarization of the electronic spin. The spin composition is measured using a Stern–Gerlach separation of spin levels, revealing that the gas becomes almost fully spin-polarized for large laser frequency detunings. In this regime, we reach the optimal operation of the MOT, with samples of typically 3× {10}8 atoms at a temperature of 15 μK. The spin polarization reduces the complexity of the radiative cooling description, which allows for a simple model accounting for our measurements. We also measure the rate of density-dependent atom losses, finding good agreement with a model based on light-induced Van der Waals forces. A minimal two-body loss rate β ∼ 2× {10}-11 cm3 s–1 is reached in the spin-polarized regime. Our results constitute a benchmark for the experimental study of ultracold gases of magnetic lanthanide atoms.

  14. Computational evidence for self-initiation in spontaneous high-temperature polymerization of methyl methacrylate.

    PubMed

    Srinivasan, Sriraj; Lee, Myung Won; Grady, Michael C; Soroush, Masoud; Rappe, Andrew M

    2011-02-17

    This paper presents computational evidence for the occurrence of diradical mechanism of self-initiation in thermal polymerization of methyl methacrylate. Two self-initiation mechanisms of interest were explored with first-principles density functional theory calculations. Singlet and triplet potential energy surfaces were constructed. The formation of two Diels-Alder adducts, cis- and trans-dimethyl 1,2-dimethylcyclobutane-1,2-dicarboxylate and dimethyl 2-methyl-5-methylidene-hexanedioate, on the singlet surface was identified. Transition states were calculated using B3LYP/6-31G* and assessed using MP2/6-31G*. The calculated energy barriers and rate constants with different levels of theory were found to show good agreement to corresponding data obtained from laboratory experiments. The presence of a diradical intermediate on the triplet surface was identified. When MCSCF/6-31G* was used, the spin-orbit coupling constant for the singlet to triplet crossover was calculated to be 2.5 cm(-1). The mechanism of monoradical generation via a hydrogen abstraction by both triplet and singlet diradicals from a third monomer was identified to be the most likely mechanism of initiation in spontaneous polymerization of methyl methacrylate.

  15. High maternal serum ferritin in early pregnancy and risk of spontaneous preterm birth.

    PubMed

    Khambalia, Amina Z; Collins, Clare E; Roberts, Christine L; Morris, Jonathan M; Powell, Katie L; Tasevski, Vitomir; Nassar, Natasha

    2015-08-14

    Previous studies have reported inconsistent associations between maternal serum ferritin concentrations and the risk of spontaneous preterm birth (sPTB). The aim of the present study was to examine the association between Fe biomarkers, including serum ferritin concentrations, and the risk of total ( 75th percentile ( ≥ 43 μg/l) (OR 1.49, 95% CI 1.06, 2.10) and >90th percentile ( ≥ 68 μg/l) (OR 1.92, 95% CI 1.25, 2.96). Increased odds of early and moderate-to-late sPTB were associated with ferritin levels >90th percentile (OR 2.50, 95% CI 1.32, 4.73) and >75th percentile (OR 1.56, 95% CI 1.03, 2.37), respectively. No association was found between the risk of sPTB and elevated sTfR levels or Fe deficiency. In conclusion, elevated maternal serum ferritin levels in early pregnancy are associated with an increased risk of sPTB from 34 weeks of gestation. The usefulness of early pregnancy ferritin levels in identifying women at risk of sPTB warrants further investigation.

  16. Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.

    PubMed

    Uebele, Victor N; Gotter, Anthony L; Nuss, Cindy E; Kraus, Richard L; Doran, Scott M; Garson, Susan L; Reiss, Duane R; Li, Yuxing; Barrow, James C; Reger, Thomas S; Yang, Zhi-Qiang; Ballard, Jeanine E; Tang, Cuyue; Metzger, Joseph M; Wang, Sheng-Ping; Koblan, Kenneth S; Renger, John J

    2009-06-01

    The epidemics of obesity and metabolic disorders have well-recognized health and economic burdens. Pharmacologic treatments for these diseases remain unsatisfactory with respect to both efficacy and side-effect profiles. Here, we have identified a potential central role for T-type calcium channels in regulating body weight maintenance and sleep. Previously, it was shown that mice lacking CaV3.1 T-type calcium channels have altered sleep/wake activity. We found that these mice were also resistant to high-fat diet-induced weight gain, without changes in food intake or sensitivity to high-fat diet-induced disruptions of diurnal rhythm. Administration of a potent and selective antagonist of T-type calcium channels, TTA-A2, to normal-weight animals prior to the inactive phase acutely increased sleep, decreased body core temperature, and prevented high-fat diet-induced weight gain. Administration of TTA-A2 to obese rodents reduced body weight and fat mass while concurrently increasing lean muscle mass. These effects likely result from better alignment of diurnal feeding patterns with daily changes in circadian physiology and potentially an increased metabolic rate during the active phase. Together, these studies reveal what we believe to be a previously unknown role for T-type calcium channels in the regulation of sleep and weight maintenance and suggest the potential for a novel therapeutic approach to treating obesity.

  17. High gain, low noise, fully complementary logic inverter based on bi-layer WSe{sub 2} field effect transistors

    SciTech Connect

    Das, Saptarshi; Roelofs, Andreas; Dubey, Madan

    2014-08-25

    In this article, first, we show that by contact work function engineering, electrostatic doping and proper scaling of both the oxide thickness and the flake thickness, high performance p- and n-type WSe{sub 2} field effect transistors (FETs) can be realized. We report record high drive current of 98 μA/μm for the electron conduction and 110 μA/μm for the hole conduction in Schottky barrier WSe{sub 2} FETs. Then, we combine high performance WSe{sub 2} PFET with WSe{sub 2} NFET in double gated transistor geometry to demonstrate a fully complementary logic inverter. We also show that by adjusting the threshold voltages for the NFET and the PFET, the gain and the noise margin of the inverter can be significantly enhanced. The maximum gain of our chemical doping free WSe{sub 2} inverter was found to be ∼25 and the noise margin was close to its ideal value of ∼2.5 V for a supply voltage of V{sub DD} = 5.0 V.

  18. Improving glucose tolerance by reducing weight gain in a polygenic obese mouse model: use of a high protein diet.

    PubMed

    Blair, A R; Strube, M L; Proietto, J; Andrikopoulos, S

    2015-03-01

    Diets to decrease body weight have limited success in achieving and importantly maintaining this weight loss long-term. It has recently been suggested that energy intake can be regulated by the amount of protein ingested, termed the protein leverage hypothesis. In this study, we determined whether a high protein diet would be effective in achieving and maintaining weight loss in a genetically obese model, the New Zealand Obese (NZO) mouse. NZO and C57BL/6J (C57) control mice were fed a high protein or chow diet for 5 weeks from weaning (3 weeks of age). Body weight and food intake were determined. Mice on the same diet were bred to produce offspring that were fed either a chow or high protein diet. Body weight, food intake, and glucose tolerance were determined. Feeding NZO and C57 mice a high protein diet for 5 weeks resulted in reduced food intake and consequently energy intake and body weight gain compared with mice on a chow diet. NZO mice fed a high protein diet showed a significant improvement in glucose tolerance compared with their chow-fed counterparts, while no difference was seen in C57 mice fed chow or protein diet. The offspring of NZO mice that were fed a high protein diet during gestation and weaning were also lighter and displayed improved glucose tolerance compared with chow fed animals. We conclude that a high protein diet is a reasonable strategy to reduce body weight gain and improve glucose tolerance in the NZO mouse, a polygenic model of obesity.

  19. Demagnetization of a Bi-2223 high-temperature superconducting coil in RT-1 through spontaneous temperature rise

    NASA Astrophysics Data System (ADS)

    Saitoh, H.; Yoshida, Z.; Ogawa, Y.; Morikawa, J.; Yano, Y.; Mizushima, T.; Mizumaki, S.; Tosaka, T.

    2012-01-01

    The Ring Trap 1 (RT-1) device produces a magnetospheric configuration for the confinement of a high- β plasma with a Bi-2223 high-temperature superconducting magnet. Here we report the results of emergency demagnetization of the superconducting coil, where we could not connect current leads, temperature measurement connectors, and connectors for a persistent-current switch (PCS) heater to the coil. The spontaneous warming of the coil caused a rise in the flux-flow resistance of the superconducting coil, and the persistent current slowly decreased as coil resistance increased. Approximately 98% of the total stored magnetic energy was safely released before the quenching of the PCS, and there was no substantial damage to the superconducting coil.

  20. Gain Evaluation of Micro-Channel-Plate Photomultipliers in the Upgraded High-B Test Facility at Jefferson Lab

    NASA Astrophysics Data System (ADS)

    Barber, Corinne; DIRC at EIC Collaboration

    2015-10-01

    The High-B test facility at Thomas Jefferson National Accelerator Facility allows researchers to evaluate the gain of compact photon sensors, such as Micro-Channel-Plate Photomultipliers (MCP-PMTs), in magnetic fields up to 5 T. These ongoing studies support the development of a Detector of Internally Reflected Cherenkov light (DIRC) to be used in an Electron Ion Collider (EIC). Here, we present our summer 2015 activities to upgrade and improve the facility, and we show results for MCP-PMT gain changes in high B-fields. To monitor the light stability delivered to the MCP-PMTs being tested, we implemented a Silicon Photomultiplier (SiPM) in the setup and calibrated the ADC reading this sensor. A 405-nm Light-Emitting Diode (LED) housed in an optical tube compatible with neutral density filters was also installed. The filters provide an alternative way of reducing the light output of the LED to operate the MCP-PMTs in a single-photon mode. We calibrated a set of filters by means of a photodiode and measured the photon flux at multiple positions relative to the LED. This information helped us to design 3D-printed holders unique to each MCP-PMT so that the photocathode receives the greatest amount of light. The improvements to the setup allow for more precise PMT gain evaluation. This team includes 7 collaborators/co-authors besides myself: Yordanka Ilieva, Kijun Park, Greg Kalicy, Carl Zorn, Pawel Nadel-Turonski, Tongtong Cao, and Lee.

  1. A High-Gain Passive UHF-RFID Tag with Increased Read Range

    PubMed Central

    Zuffanelli, Simone; Aguila, Pau; Zamora, Gerard; Paredes, Ferran; Martin, Ferran; Bonache, Jordi

    2016-01-01

    In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm). The measured read range exhibits a maximum value of 17.5 m at the 902–928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags. PMID:27455274

  2. A High-Gain Passive UHF-RFID Tag with Increased Read Range.

    PubMed

    Zuffanelli, Simone; Aguila, Pau; Zamora, Gerard; Paredes, Ferran; Martin, Ferran; Bonache, Jordi

    2016-07-22

    In this work, a passive ultra-high frequency radio-frequency identification UHF-RFID tag based on a 1.25 wavelengths thin dipole antenna is presented for the first time. The length of the antenna is properly chosen in order to maximize the tag read range, while maintaining a reasonable tag size and radiation pattern. The antenna is matched to the RFID chip by means of a very simple matching network based on a shunt inductance. A tag prototype, based on the Alien Higgs-3 chip, is designed and fabricated. The overall dimensions are 400 mm × 14.6 mm, but the tag width for most of its length is delimited by the wire diameter (0.8 mm). The measured read range exhibits a maximum value of 17.5 m at the 902-928 MHz frequency band. This represents an important improvement over state-of-the-art passive UHF-RFID tags.

  3. On the long-memory filtering gain in optical high-order QAM transmission systems.

    PubMed

    Peng, Wei-Ren; Takahashi, Hidenori; Tsuritani, Takehiro; Morita, Itsuro

    2013-05-06

    In this paper, we verify the effectiveness of the last-stage long memory filter (LMF) in mitigating the long-memory response (LMR) of hardware, i.e. the transmitter and receiver. Based on the experimental results, we draw the following conclusions: 1) LMF can effectively mitigate the LMR impact, such as transmitter reflections, and its efficiency is more significant for high-order QAM signals. 2) Using LMF, a partially-correlated pattern exhibits similar performance to that of an uncorrelated pattern both in back-to-back and after 320-km standard single mode fiber (SSMF) transmission. Moreover, a simple solution to the computational complexity of LMF, effective-tap (ET) LMF, is proposed and demonstrated.

  4. Sustained mild hypergravity reduces spontaneous cardiac baroreflex sensitivity.

    PubMed

    Yanagida, Ryo; Ogawa, Yojiro; Ueda, Kaname; Aoki, Ken; Iwasaki, Ken-ichi

    2014-10-01

    Head-to-foot gravitational force >1G (+Gz hypergravity) augments venous pooling in the lower body and reduces central blood volume during exposure, compared with 1Gz. Central hypovolemia has been reported to reduce spontaneous cardiac baroreflex sensitivity. However, no investigations have examined spontaneous cardiac baroreflex sensitivity during exposure to sustained mild +Gz hypergravity. We therefore hypothesized that mild +Gz hypergravity would reduce spontaneous cardiac baroreflex sensitivity, compared with 1Gz. To test this hypothesis, we examined spontaneous cardiac baroreflex sensitivity in 16 healthy men during exposure to mild +Gz hypergravity using a short-arm centrifuge. Beat-to-beat arterial blood pressure (tonometry) and R-R interval (electrocardiography) were obtained during 1Gz and 1.5Gz exposures. Spontaneous cardiac baroreflex sensitivity was assessed by sequence slope and transfer function gain. Stroke volume was calculated from the arterial pressure waveform using a three-element model. All indices of spontaneous cardiac baroreflex sensitivity decreased significantly (up slope: 18.6±2.3→12.7±1.6ms/mmHg, P<0.001; down slope: 19.0±2.5→13.2±1.3ms/mmHg, P=0.002; transfer function gain in low frequency: 14.4±2.2→10.1±1.1ms/mmHg, P=0.004; transfer function gain in high frequency: 22.2±7.5→12.4±3.5ms/mmHg, P<0.001). Stroke volume decreased significantly (88±5→80±6ml, P=0.025). Moreover, although systolic arterial pressure variability increased, R-R interval variability did not increase. These results suggest that even mild +Gz hypergravity reduces spontaneous cardiac baroreflex sensitivity, increasing the risk of cardiovascular disturbance during the exposure.

  5. Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain

    PubMed Central

    Pardi, María Belén; Ogando, Mora Belén; Schinder, Alejandro F; Marin-Burgin, Antonia

    2015-01-01

    Adult hippocampal neurogenesis provides the dentate gyrus with heterogeneous populations of granule cells (GC) originated at different times. The contribution of these cells to information encoding is under current investigation. Here, we show that incoming spike trains activate different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of stimulus frequencies, whereas mature GC are less responsive at high frequencies. This difference is dictated by feedforward inhibition, which restricts mature GC activation. Yet, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, hippocampal inputs activate two populations of neurons with variable frequency filters: immature cells, with wide‐range responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow frequency response, that are precise at informing the beginning of the stimulus, but with a sparse activity. DOI: http://dx.doi.org/10.7554/eLife.08764.001 PMID:26163657

  6. Mini-open PLIF for Moderate to High Grade Spondylolisthesis: Technique to Achieve Spontaneous Reduction

    PubMed Central

    Jeong, Se Ho; Kim, Hyeun Sung

    2015-01-01

    Objective The purpose of this study was to evaluate the surgical technique and outcome of mini-open posterior lumbar interbody fusion (PLIF) under circumferential releasing technique. Methods Fourty patients who underwent mini-open PLIF using the percutaneous screw fixation system for Meyerding Grade II spondylolisthesis or more were retrospectively studied. After complete circumferential release, the slipped vertebrae would tend to obtain spontaneous reduction, and with compressive force by percutaneous screw fixation, additional reduction could be achieved. The radiological measurements including slippage reduction, disc height, restoration of lumbar lordotic angle and focal segmental angle were analyzed. The clinical outcome was assessed using the visual analog scale (VAS) and low back outcome score (LBOS), and procedure related complications were also analyzed. Results Slippage percentage was improved from 38.0±12.6% to 9.3±7.8% and lumbar lordotic angle was changed from 43.0±13.8° to 48.2±10.3°. Focal segmental angle improved from 10.1±8.5° to 15.9±6.0°. The mean LBOS and mean pain score were also improved significantly. Complications included one case of medial penetration of pedicle border and two cases of transient radiculopathy. However, there were no signs of neurological aggravation or fusion failure during the follow-up period. Conclusion Mini-open PLIF using the percutaneous screw fixation following complete circumferential release can be safe and effective treatment for even moderate to severe grade spondylolisthesis. PMID:26834812

  7. Semi-global robust output regulation of minimum-phase nonlinear systems based on high-gain nonlinear internal model

    NASA Astrophysics Data System (ADS)

    Wei, Xile; Lu, Meili; Wang, Jiang; Tsang, K. M.; Deng, Bin; Che, Yanqiu

    2010-05-01

    We consider the assumption of existence of the general nonlinear internal model that is introduced in the design of robust output regulators for a class of minimum-phase nonlinear systems with rth degree (r ≥ 2). The robust output regulation problem can be converted into a robust stabilisation problem of an augmented system consisting of the given plant and a high-gain nonlinear internal model, perfectly reproducing the bounded including not only periodic but also nonperiodic exogenous signal from a nonlinear system, which satisfies some general immersion assumption. The state feedback controller is designed to guarantee the asymptotic convergence of system errors to zero manifold. Furthermore, the proposed scheme makes use of output feedback dynamic controller that only processes information from the regulated output error by using high-gain observer to robustly estimate the derivatives of the regulated output error. The stabilisation analysis of the resulting closed-loop systems leads to regional as well as semi-global robust output regulation achieved for some appointed initial condition in the state space, for all possible values of the uncertain parameter vector and the exogenous signal, ranging over an arbitrary compact set.

  8. Sensitivity Gains, Linearity, and Spectral Reproducibility in Nonuniformly Sampled Multidimensional MAS NMR Spectra of High Dynamic Range.

    SciTech Connect

    Suiter, Christopher L.; Paramasivam, Sivakumar; Hou, Guangjin; Sun, Shangjin; Rice, David M.; Hoch, Jeffrey C.; Rovnyak, David S.; Polenova, Tatyana E.

    2014-04-22

    Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear 13C–13C correlation spectra. We demonstrate on model compounds and on 1–73-(U-13C,15N)/74–108-(U-15N) E. coli thioredoxin reassembly, that with appropriately constructed 50 % NUS schedules inherent sensitivity gains of 1.7–2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear 13C–13C MAS correlation experiments that yield high quality artifact-free datasets.

  9. Effects of Dietary Fibers on Weight Gain, Carbohydrate Metabolism and Gastric Ghrelin Gene Expression in High Fat Diet Fed Mice

    PubMed Central

    Wang, Zhong Q.; Zuberi, Aamir; Zhang, Xian H.; Macgowan, Jacalyn; Qin, Jianhua; Ye, Xin; Son, Leslie; Wu, Qinglin; Lian, Kun; Cefalu, William T.

    2009-01-01

    Diets that are high in dietary fiber are reported to have substantial health benefits. We sought to compare the metabolic effects for three types of dietary fibers, i.e. sugar cane fiber (SCF), psyllium (PSY) and cellulose (CEL) on body weight, carbohydrate metabolism and stomach ghrelin gene expression in a high-fat diet fed mouse model. Thirty-six male mice (C57BL/6) were randomly divided into four groups that consumed high fat-diets or high fat diet containing 10% SCF, PSY, and CEL respectively. After baseline measurements were assessed for body weight, plasma insulin, glucose, leptin and glucagon-like peptide-1 (GLP-1), animals were treated for 12 weeks. Parameters were re-evaluated at end of study. Whereas there was no difference at the baseline, body weight gains in the PSY and SCF groups were significantly lower than in CEL group at end of study, No difference in body weight was observed between the PSY and SCF animals. Body composition analysis demonstrated that fat mass in the SCF group was considerably lower than in the CEL and HFD groups. In addition, fasting plasma glucose and insulin and areas under curve of IPGTT were also significantly lower in the SCF and PSY groups than in the CEL and HFD groups. Moreover, fasting plasma concentrations of leptin were significantly lower and GLP-1 level was two-fold higher in the SCF and PSY mice than in the HFD and CEL mice. Ghrelin mRNA levels of stomach in SCF groups were significantly lower than in CEL and HFD groups as well. These results suggest differences in response to dietary fiber intake in this animal model as high fat diets incorporating dietary fibers such as SCF and PSY appeared to attenuate weight gain, enhance insulin sensitivity, and modulate leptin and GLP-1 secretion and gastric ghrelin gene expression. PMID:17998014

  10. Ascitic Fluid High Sensitive C-Reactive Protein (hs-CRP). A Prognostic Marker in Cirrhosis with Spontaneous Bacterial Peritonitis

    PubMed Central

    Kadam, Nakul; Shukla, Samarth; Gupta, Kriti

    2016-01-01

    Introduction C-Reactive Protein (CRP) is an acute phase reactant. Its level increases in the presence of acute or chronic inflammation and infections. High sensitive CRP (hs-CRP) is more sensitive than CRP as an inflammatory marker. High sensitive CRP has been known to be elevated in chronic liver diseases and Spontaneous Bacterial Peritonitis (SBP). Aim The aim of the study was to establish the role of ascitic fluid high sensitive C-reactive protein (hs –CRP) as a prognostic indicator in patients with SBP. Materials and Methods A total of 100 patients with decompensated cirrhosis admitted in medicine ward and ICU were included, of which 50 patients of acute bacterial peritonitis were used as study group and 50 patients of sterile ascites were used as control group. Hs-CRP level of cases and controls were estimated. SBP cases were treated with its standard recommended antibiotic therapy and hs-CRP level was again estimated after 5 days of antibiotic therapy or at the time of discharge. Results The mean level of hs-CRP before antibiotic therapy of the patients with SBP was significantly higher than that of the patients without spontaneous bacterial peritonitis (t98=17.72; p=0.0001). The mean level of hs-CRP at 5th day or discharge after initiation of antibiotic therapy was significantly lower than that of level of hs-CRP before initiation of antibiotic therapy (p<0.05). The mean hs-CRP of the cases with poor outcome (death and prolonged hospital stay) was significantly higher than others. Conclusion Ascitic fluid hs-CRP level can be considered as a surrogate prognostic marker in cases of Cirrhosis with SBP. PMID:27190862

  11. Active pulse shaping for end-pumped Nd:YVO4 amplifier with high gain.

    PubMed

    Nie, Mingming; Liu, Qiang; Ji, Encai; Cao, Xuezhe; Fu, Xing; Gong, Mali

    2017-03-15

    We demonstrated the active shaping for a solid-state Nd:YVO4 amplifier with a high average gain of 39.2 dB. The average output power was 8.3 W with respect to the input power of 1 mW. A range of common and useful pulse shapes was generated at the final output. In addition, a very flat square pulse was produced with a root-mean-square less than 3% in amplitude. A numerical method was proposed to realize active shaping without an experimental test for the Nd:YVO4 amplifier, showing great potential for the design of lasers with both high peak power (>100  kW) and a desired pulse shape.

  12. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.

    PubMed

    Moy, Gregory A; McNay, Ewan C

    2013-01-17

    Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer's disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration on metabolism and cognitive performance, both in control rats and in rats placed on a high-fat diet. The effects of caffeine were significant: caffeine both (i) prevented the weight-gain associated with the high-fat diet and (ii) prevented cognitive impairment. Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals. These data confirm that caffeine may serve as a neuroprotective agent against cognitive impairment caused by obesity and/or a high-fat diet. Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.

  13. Laser propagation through full-scale, high-gain MagLIF gas pipes using the NIF

    NASA Astrophysics Data System (ADS)

    Pollock, Bradley; Sefkow, Adam; Goyon, Clement; Strozzi, David; Khan, Shahab; Rosen, Mordy; Campbell, Mike; Logan, Grant; Peterson, Kyle; Moody, John

    2016-10-01

    The first relevant measurements of laser propagation through surrogate high-gain MagLIF gas pipe targets at full scale have been performed at the NIF, using 30 kJ of laser drive from one quad in a 10 ns pulse at an intensity of 2e14 W/cm2. The unmagnetized pipe is filled with 1 atm of 99%/1% neopentane/Ar, and uses an entrance window of 0.75 um polyimide and an exit window of 0.3 um of Ta backed with 5 um of polyimide. Side-on x-ray emission from the plasma is imaged through the 100 um-thick epoxy wall onto a framing camera at four times during the drive, and is in excellent agreement with pre-shot HYDRA radiation-hydrodynamics modeling. X-ray emission from the Ta exit plane is imaged onto a streak camera to determine the timing and intensity of the laser burning through the pipe, and the Ar emission from the center of the pipe is spectrally- and temporally-resolved to determine the plasma electron temperature. Backscatter is measured throughout the laser drive, and is found to be of significance only when the laser reaches the Ta exit plane and produces SBS. These first results in unmagnetized surrogate gas fills are encouraging since they demonstrate sufficient laser energy absorption and low LPI losses within high-density long-scale-length plasmas for proposed high-gain MagLIF target designs. We will discuss plans to magnetize targets filled with high-density DT gas in future experiments. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the National Nuclear Security Administration under Contract No. DE-AC04-94AL85000.

  14. Verbal marking of affect by children with Asperger Syndrome and high functioning autism during spontaneous interactions with family members.

    PubMed

    Müller, Eve; Schuler, Adriana

    2006-11-01

    Verbal marking of affect by older children with Asperger Syndrome (AS) and high functioning autism (HFA) during spontaneous interactions is described. Discourse analysis of AS and HFA and typically developing children included frequency of affective utterances, affective initiations, affective labels and affective explanations, attribution of affective responses to self and others, and positive and negative markers of affect. Findings indicate that children with AS and HFA engaged in a higher proportion of affect marking and provided a higher proportion of affective explanations than typically developing children, yet were less likely to initiate affect marking sequences or talk about the affective responses of others. No significant differences were found between groups in terms of the marking of positive and negative affect.

  15. Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice.

    PubMed

    Han, Yo-Han; Kee, Ji-Ye; Park, Jinbong; Kim, Hye-Lin; Jeong, Mi-Young; Kim, Dae-Seung; Jeon, Yong-Deok; Jung, Yunu; Youn, Dong-Hyun; Kang, JongWook; So, Hong-Seob; Park, Raekil; Lee, Jong-Hyun; Shin, Soyoung; Kim, Su-Jin; Um, Jae-Young; Hong, Seung-Heon

    2016-09-01

    Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti-inflammation, anti-cancer, and antioxidant, there have been no reports on the anti-obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti-obesity effect and mediates the AMP-activated protein kinase (AMPK) pathway. We investigated the anti-adipogenic effect of ARC using 3T3-L1 pre-adipocytes and human adipose tissue-derived mesenchymal stem cells (hAMSCs). In high-fat diet (HFD)-induced obese mice, whether ARC can inhibit weight gain was investigated. We found that ARC reduced weight gain, fat pad weight, and triglycerides in HFD-induced obese mice. ARC also inhibited the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in in vitro and in vivo. Furthermore, ARC induced the AMPK activation resulting in down-modulation of adipogenesis-related factors including PPARγ, C/EBPα, fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase. This study demonstrates that ARC can reduce key adipogenic factors by activating the AMPK in vitro and in vivo and suggests a therapeutic implication of ARC for obesity treatment. J. Cell. Biochem. 117: 2067-2077, 2016. © 2016 Wiley Periodicals, Inc.

  16. A new design methodology of obtaining wide band high gain broadband parametric source for infrared wavelength applications

    NASA Astrophysics Data System (ADS)

    Maji, Partha Sona; Roy Chaudhuri, Partha

    2016-03-01

    In this article, we have presented a new design methodology of obtaining wide band parametric sources based on highly nonlinear chalcogenide material of As2S3. The dispersion profile of the photonic crystal fiber (PCF) has been engineered wisely by reducing the diameter of the second air-hole ring to have a favorable higher order dispersion parameter. The parametric gain dependence upon fiber length, pump power, and different pumping wavelengths has been investigated in detail. Based upon the nonlinear four wave mixing phenomenon, we are able to achieve a wideband parametric amplifier with peak gain of 29 dB with FWHM of ≈2000 nm around the IR wavelength by proper tailoring of the dispersion profile of the PCF with a continuous wave Erbium (Er3+)-doped ZBLAN fiber laser emitting at 2.8 μm as the pump source with an average power of 5 W. The new design methodology will unleash a new dimension to the chalcogenide material based investigation for wavelength translation around IR wavelength band.

  17. Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet.

    PubMed

    Gil, Krzysztof; Bugajski, A; Thor, P

    2011-12-01

    There is growing evidence that vagus nerve stimulation (VNS) has a suppressive effect on both short- and long-term feeding in animal models. We previously showed that long-term VNS (102 days) with low-frequency electrical impulses (0.05 Hz) decreased food intake and body weight in rats. In the present study, we investigated the effect of high frequency (10 Hz) VNS on feeding behavior and appetite in rats fed a high-fat diet; peptide secretion and other parameters were assessed as well. Adult male Wistar rats were each implanted subcutaneously with a microstimulator (MS) and fed a high-fat diet throughout the entire study period (42 days). The left vagus nerve was stimulated by rectangular electrical pulses (10 ms, 200 mV, 10 Hz, 12 h a day) generated by the MS. Body weight and food intake were measured each morning. At the end of the experimental period, animals were euthanized and blood samples were taken. Serum levels of ghrelin, leptin and nesfatin-1 were assessed using radioimmunoassays. Adipose tissue content was evaluated by weighing epididymal fat pads, which were incised at the time of sacrifice. To determine whether VNS activated the food-related areas of the brain, neuronal c-Fos induction in the nuclei of the solitary tract (NTS) was assessed. Chronic vagus nerve stimulation significantly decreased food intake, body weight gain and epididymal fat pad weight in animals that received VNS compared with control animals. Significant neuronal responses in the NTS were observed following VNS. Finally, serum concentrations of ghrelin were increased, while serum levels of leptin were decreased. Although not significant, serum nesfatin-1 levels were also elevated. These results support the theory that VNS leads to reductions in food intake, body weight gain and adipose tissue by increasing brain satiety signals conducted through the vagal afferents. VNS also evoked a feed-related hormonal response, including elevated blood concentrations of nesfatin-1.

  18. Theory of quantum frequency conversion and type-II parametric down-conversion in the high-gain regime

    NASA Astrophysics Data System (ADS)

    Christ, Andreas; Brecht, Benjamin; Mauerer, Wolfgang; Silberhorn, Christine

    2013-05-01

    Frequency conversion (FC) and type-II parametric down-conversion (PDC) processes serve as basic building blocks for the implementation of quantum optical experiments: type-II PDC enables the efficient creation of quantum states such as photon-number states and Einstein-Podolsky-Rosen (EPR)-states. FC gives rise to technologies enabling efficient atom-photon coupling, ultrafast pulse gates and enhanced detection schemes. However, despite their widespread deployment, their theoretical treatment remains challenging. Especially the multi-photon components in the high-gain regime as well as the explicit time-dependence of the involved Hamiltonians hamper an efficient theoretical description of these nonlinear optical processes. In this paper, we investigate these effects and put forward two models that enable a full description of FC and type-II PDC in the high-gain regime. We present a rigorous numerical model relying on the solution of coupled integro-differential equations that covers the complete dynamics of the process. As an alternative, we develop a simplified model that, at the expense of neglecting time-ordering effects, enables an analytical solution. While the simplified model approximates the correct solution with high fidelity in a broad parameter range, sufficient for many experimental situations, such as FC with low efficiency, entangled photon-pair generation and the heralding of single photons from type-II PDC, our investigations reveal that the rigorous model predicts a decreased performance for FC processes in quantum pulse gate applications and an enhanced EPR-state generation rate during type-II PDC, when EPR squeezing values above 12 dB are considered.

  19. Restricted feeding of a high-fat diet reduces spontaneous metastases of Lewis lung carcinoma in C57BL/6 mice

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Obesity is a risk factor for cancer. We previously reported that consumption of a high-fat diet enhances metastasis in mice (Yan, Clin Exp Metastasis 2010). The present study investigated the effects of restricted feeding of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma (LLC) i...

  20. Gimbals Drive and Control Electronics Design, Development and Testing of the LRO High Gain Antenna and Solar Array Systems

    NASA Technical Reports Server (NTRS)

    Chernyakov, Boris; Thakore, Kamal

    2010-01-01

    Launched June 18, 2009 on an Atlas V rocket, NASA's Lunar Reconnaissance Orbiter (LRO) is the first step in NASA's Vision for Space Exploration program and for a human return to the Moon. The spacecraft (SC) carries a wide variety of scientific instruments and provides an extraordinary opportunity to study the lunar landscape at resolutions and over time scales never achieved before. The spacecraft systems are designed to enable achievement of LRO's mission requirements. To that end, LRO's mechanical system employed two two-axis gimbal assemblies used to drive the deployment and articulation of the Solar Array System (SAS) and the High Gain Antenna System (HGAS). This paper describes the design, development, integration, and testing of Gimbal Control Electronics (GCE) and Actuators for both the HGAS and SAS systems, as well as flight testing during the on-orbit commissioning phase and lessons learned.

  1. Highly entangled photons and rapidly responding polarization qubit phase gates in a room-temperature active Raman gain medium

    SciTech Connect

    Hang Chao; Huang Guoxiang

    2010-11-15

    We present a scheme for obtaining entangled photons and quantum phase gates in a room-temperature four-state tripod-type atomic system with two-mode active Raman gain (ARG). We analyze the linear and nonlinear optical responses of this ARG system and show that the scheme is fundamentally different from those based on electromagnetically induced transparency and hence can avoid significant probe-field absorption as well as a temperature-related Doppler effect. We demonstrate that highly entangled photon pairs can be produced and rapidly responding polarization qubit phase gates can be constructed based on the unique features of the enhanced cross-phase-modulation and superluminal probe-field propagation of the system.

  2. Transverse-to-Longitudinal Emittance Exchange to Improve Performance of High-Gain Free-Electron Lasers

    SciTech Connect

    Emma, P.; Huang, Z.; Kim, K.-J.; Piot, P.; /Northern Illinois U. /Fermilab

    2006-09-21

    The ability to generate small transverse emittance is perhaps the main limiting factor for the performance of high-gain x-rays free-electron lasers (FELs). Noting that beams from an rf photocathode gun can have energy spread much smaller than required for efficient FEL interaction, we present a method to produce normalized transverse emittance at or below about 0.1 {micro}m, which will lead to a significantly shorter length undulator as well as a lower electron beam energy for an x-ray FEL project. The beam manipulation consists of producing an unequal partition of the initially equal emittances into two dissimilar emittances by a flat beam technique and exchanging the larger transverse emittance with a small longitudinal emittance. We study various issues involved in the manipulation. In particular, a new emittance exchange optics we found enables an exact emittance exchange necessary for this scheme.

  3. Self-amplified spontaneous emission for a single pass free-electron laser

    NASA Astrophysics Data System (ADS)

    Giannessi, L.; Alesini, D.; Antici, P.; Bacci, A.; Bellaveglia, M.; Boni, R.; Boscolo, M.; Briquez, F.; Castellano, M.; Catani, L.; Chiadroni, E.; Cianchi, A.; Ciocci, F.; Clozza, A.; Couprie, M. E.; Cultrera, L.; Dattoli, G.; Del Franco, M.; Dipace, A.; di Pirro, G.; Doria, A.; Drago, A.; Fawley, W. M.; Ferrario, M.; Ficcadenti, L.; Filippetto, D.; Frassetto, F.; Freund, H. P.; Fusco, V.; Gallerano, G.; Gallo, A.; Gatti, G.; Ghigo, A.; Giovenale, E.; Marinelli, A.; Labat, M.; Marchetti, B.; Marcus, G.; Marrelli, C.; Mattioli, M.; Migliorati, M.; Moreno, M.; Mostacci, A.; Orlandi, G.; Pace, E.; Palumbo, L.; Petralia, A.; Petrarca, M.; Petrillo, V.; Poletto, L.; Quattromini, M.; Rau, J. V.; Reiche, S.; Ronsivalle, C.; Rosenzweig, J.; Rossi, A. R.; Rossi Albertini, V.; Sabia, E.; Serafini, L.; Serluca, M.; Spassovsky, I.; Spataro, B.; Surrenti, V.; Vaccarezza, C.; Vescovi, M.; Vicario, C.

    2011-06-01

    SPARC (acronym of “Sorgente Pulsata ed Amplificata di Radiazione Coerente”, i.e. Pulsed and Amplified Source of Coherent Radiation) is a single pass free-electron laser designed to obtain high gain amplification at a radiation wavelength of 500 nm. Self-amplified spontaneous emission has been observed driving the amplifier with the high-brightness beam of the SPARC linac. We report measurements of energy, spectra, and exponential gain. Experimental results are compared with simulations from several numerical codes.

  4. Spontaneous aggregation of lithium ion coordination polymers in fluorinated electrolytes for high-voltage batteries

    DOE PAGES

    Malliakas, Christos D.; Leung, Kevin; Pupek, Krzysztof Z.; ...

    2016-03-31

    Fluorinated carbonate solvents are pursued as liquid electrolytes for high-voltage Li-ion batteries. We report aggregation of [Li+(FEC)3]n polymer species from fluoroethylene carbonate containing electrolytes and scrutinized the causes for this behavior.

  5. Spontaneous aggregation of lithium ion coordination polymers in fluorinated electrolytes for high-voltage batteries.

    PubMed

    Malliakas, Christos D; Leung, Kevin; Pupek, Krzysztof Z; Shkrob, Ilya A; Abraham, Daniel P

    2016-04-28

    Fluorinated carbonates are pursued as liquid electrolyte solvents for high-voltage Li-ion batteries. Here we report aggregation of [Li(+)(FEC)3]n polymer species in fluoroethylene carbonate containing electrolytes and scrutinize the causes for this behavior.

  6. Defective TiO2 with high photoconductive gain for efficient and stable planar heterojunction perovskite solar cells

    NASA Astrophysics Data System (ADS)

    Li, Yanbo; Cooper, Jason K.; Liu, Wenjun; Sutter-Fella, Carolin M.; Amani, Matin; Beeman, Jeffrey W.; Javey, Ali; Ager, Joel W.; Liu, Yi; Toma, Francesca M.; Sharp, Ian D.

    2016-08-01

    Formation of planar heterojunction perovskite solar cells exhibiting both high efficiency and stability under continuous operation remains a challenge. Here, we show this can be achieved by using a defective TiO2 thin film as the electron transport layer. TiO2 layers with native defects are deposited by electron beam evaporation in an oxygen-deficient environment. Deep-level hole traps are introduced in the TiO2 layers and contribute to a high photoconductive gain and reduced photocatalytic activity. The high photoconductivity of the TiO2 electron transport layer leads to improved efficiency for the fabricated planar devices. A maximum power conversion efficiency of 19.0% and an average PCE of 17.5% are achieved. In addition, the reduced photocatalytic activity of the TiO2 layer leads to enhanced long-term stability for the planar devices. Under continuous operation near the maximum power point, an efficiency of over 15.4% is demonstrated for 100 h.

  7. Defective TiO2 with high photoconductive gain for efficient and stable planar heterojunction perovskite solar cells.

    PubMed

    Li, Yanbo; Cooper, Jason K; Liu, Wenjun; Sutter-Fella, Carolin M; Amani, Matin; Beeman, Jeffrey W; Javey, Ali; Ager, Joel W; Liu, Yi; Toma, Francesca M; Sharp, Ian D

    2016-08-18

    Formation of planar heterojunction perovskite solar cells exhibiting both high efficiency and stability under continuous operation remains a challenge. Here, we show this can be achieved by using a defective TiO2 thin film as the electron transport layer. TiO2 layers with native defects are deposited by electron beam evaporation in an oxygen-deficient environment. Deep-level hole traps are introduced in the TiO2 layers and contribute to a high photoconductive gain and reduced photocatalytic activity. The high photoconductivity of the TiO2 electron transport layer leads to improved efficiency for the fabricated planar devices. A maximum power conversion efficiency of 19.0% and an average PCE of 17.5% are achieved. In addition, the reduced photocatalytic activity of the TiO2 layer leads to enhanced long-term stability for the planar devices. Under continuous operation near the maximum power point, an efficiency of over 15.4% is demonstrated for 100 h.

  8. Defective TiO2 with high photoconductive gain for efficient and stable planar heterojunction perovskite solar cells

    PubMed Central

    Li, Yanbo; Cooper, Jason K.; Liu, Wenjun; Sutter-Fella, Carolin M.; Amani, Matin; Beeman, Jeffrey W.; Javey, Ali; Ager, Joel W.; Liu, Yi; Toma, Francesca M.; Sharp, Ian D.

    2016-01-01

    Formation of planar heterojunction perovskite solar cells exhibiting both high efficiency and stability under continuous operation remains a challenge. Here, we show this can be achieved by using a defective TiO2 thin film as the electron transport layer. TiO2 layers with native defects are deposited by electron beam evaporation in an oxygen-deficient environment. Deep-level hole traps are introduced in the TiO2 layers and contribute to a high photoconductive gain and reduced photocatalytic activity. The high photoconductivity of the TiO2 electron transport layer leads to improved efficiency for the fabricated planar devices. A maximum power conversion efficiency of 19.0% and an average PCE of 17.5% are achieved. In addition, the reduced photocatalytic activity of the TiO2 layer leads to enhanced long-term stability for the planar devices. Under continuous operation near the maximum power point, an efficiency of over 15.4% is demonstrated for 100 h. PMID:27534585

  9. A PMT-like high gain avalanche photodiode based on GaN/AlN periodically stacked structure

    NASA Astrophysics Data System (ADS)

    Zheng, Jiyuan; Wang, Lai; Wu, Xingzhao; Hao, Zhibiao; Sun, Changzheng; Xiong, Bing; Luo, Yi; Han, Yanjun; Wang, Jian; Li, Hongtao; Brault, Julien; Matta, Samuel; Khalfioui, Mohamed Al; Yan, Jianchang; Wei, Tongbo; Zhang, Yun; Wang, Junxi

    2016-12-01

    Avalanche photodiode (APD) has been intensively investigated as a promising candidate to replace the bulky and fragile photomultiplier tube (PMT) for weak light detection. However, the performance of most available APDs is barely satisfactory compared to that of the PMTs because of inter-valley scattering. Here, we demonstrate a PMT-like APD based on GaN/AlN periodically stacked-structure (PSS), in which the electrons encounter a much less inter-valley scattering during transport than holes. Uni-directional avalanche takes place with a high efficiency. According to our simulations based on a PSS with GaN (10 nm)/AlN (10 nm) in each period, the probability for electrons to trigger ionization in each cycle can reach as high as 80%, while that for holes is only 4%. A record high and stable gain (104) with a low ionization coefficient ratio of 0.05 is demonstrated under a constant bias in a prototype device.

  10. Spontaneous aggregation of lithium ion coordination polymers in fluorinated electrolytes for high-voltage batteries

    SciTech Connect

    Malliakas, Christos D.; Leung, Kevin; Pupek, Krzysztof Z.; Shkrob, Ilya A.; Abraham, Daniel P.

    2016-03-31

    Fluorinated carbonate solvents are pursued as liquid electrolytes for high-voltage Li-ion batteries. We report aggregation of [Li+(FEC)3]n polymer species from fluoroethylene carbonate containing electrolytes and scrutinized the causes for this behavior.

  11. Effects of Spontaneous and Induced Lookbacks on Self-Perceived High and Low Ability Comprehenders.

    ERIC Educational Resources Information Center

    Alvermann, Donna E.; Van Arnam, Steve

    A study was conducted to determine whether high and low ability comprehenders would benefit from induced lookbacks over naturally occurring text. Subjects were 64 tenth grade students selected on the basis of how their self-perceived proficiency matched their actual reading achievement as measured on a standardized test. The subjects were randomly…

  12. HBV/HCV co-infection is associated with a high level of HCV spontaneous clearance among drug users and blood donors in China.

    PubMed

    Xiong, H; Rong, X; Wang, M; Xu, R; Huang, K; Liao, Q; Huang, J; Chen, J; Li, C; Tang, X; Shan, Z; Zhang, M; Nelson, K; Fu, Y

    2016-12-12

    Understanding the biology of spontaneous clearance of hepatitis C virus (HCV) infection could lead to improved strategies to prevent the sequelae associated with chronic HCV infection. Chronic infections with hepatitis virus are very common in China, but the factors associated with spontaneous clearance of HCV have not been adequately studied. We evaluated the spontaneous clearance of HCV among 1918 drug users and 1526 HCV-seropositive blood donors in Guangzhou, China. Among participants who were co-infected with hepatitis B virus (HBV), 41.38% of drug users and 39.47% of blood donors had cleared their HCV infection without antiviral therapy compared to 9.41% of drug users and 16.73% of blood donors who were mono-infected with a single virus (P<.01). The proportion of subjects who had cleared their HCV infection was significantly greater in the co-infected subjects whose serum HBV DNA was greater than 2000IU/mL than those with lower levels. A multiple logistic regression analysis found female gender, IL28B rs8099917 TT genotype, HBV co-infection and blood donors (vs drug users) associated with increased spontaneous clearance of HCV infection. Although acute HCV infections are common in China, the incidence of chronic HCV may be reduced among the high prevalence of chronic HBV and IL28B genotypes associated with spontaneous clearance of HCV in Chinese populations.

  13. Effects of high salt diets and taurine on the development of hypertension in the stroke-prone spontaneously hypertensive rat.

    PubMed

    Dawson, R; Liu, S; Jung, B; Messina, S; Eppler, B

    2000-01-01

    Taurine is present in high concentrations in mammalian tissues and has been implicated in cardiovascular control mechanisms. The aim of the present study was to evaluate the ability of taurine to attenuate salt-induced elevations in blood pressure and markers of damage to the kidney and cardiovascular system in stroke prone spontaneously hypertensive rats (SPSHR). Male SPSHR (6 weeks old) were placed on high salt diets that contained 1% (w/w) NaCl added to their normal chow for 84 days and then were switched to 3% added NaCl for the remaining 63 days of the study. SPSHR was given 1.5% taurine in the drinking water (n = 8), a taurine free diet (n = 8) or normal chow (n = 8). A final control group (n = 6) was not given high salt diets. High salt diets caused an acceleration in the development of hypertension in all groups. Taurine supplementation reduced ventricular hypertrophy and decreased urinary excretion of protein and creatinine. The taurine free diet did not alter serum or urinary excretion of taurine, but did result in elevated urinary nitrogen excretion, increased serum cholesterol levels, and impaired performance in a spatial learning task. Alterations in dietary taurine intake did not alter urinary or serum electrolytes (Na+, K+), but taurine supplementation did attenuate a rise in serum calcium seen with the high salt diets. Urinary excretion (microg/24h) of epinephrine and dopamine was significantly reduced in SPSHR given 1% NaCl in the diet, but this effect was not seen in SPSHR on taurine free or supplemented diets. Taurine supplementation showed cardioprotective and renoprotective effects in SPSHR given high salt diets.

  14. Measurement and Simulation of Spontaneous Raman Scattering Spectra in High-Pressure, Fuel-Rich H2-Air Flames

    NASA Technical Reports Server (NTRS)

    Kojima, Jun; Nguyen, Quang-Viet

    2003-01-01

    Rotational vibrational spontaneous Raman spectra (SRS) of H2, N2, and H2O have been measured in H2-air flames at pressures up to 30 atm as a first stem towards establishing a comprehensive Raman spectral database for temperatures and species in high-pressure combustion. A newly developed high-pressure burner facility provides steady, reproducible flames with a high degree of flow precision. We have obtained an initial set of measurements that indicate the spectra are of sufficient quality in terms of spectral resolution, wavelength coverage, and signal-to-noise ratio for use in future reference standards. The fully resolved Stokes and anti-Stokes shifted SRS spectra were collected in the visible wavelength range (400-700 nm) using pulse-stretched 532 nm excitation and a non-intensified CCD spectrograph with a high-speed shutter. Reasonable temperatures were determined via the intensity distribution of rotational H2 lines at stoichiometry and fuel-rich conditions. Theoretical Raman spectra of H2 were computed using a semi-classical harmonic-oscillator model with recent pressure broadening data and were compared with experimental results. The data and simulation indicated that high-J rotational lines of H2 might interfere with the N2 vibrational Q-branch lines, and this could lead to errors in N2-Raman thermometry based on the line-fitting method. From a comparison of N2 Q-branch spectra in lean H2 low-pressure (1.2 atm) and high-pressure (30 atm) flames, we found no significant line-narrowing or -broadening effects at the current spectrometer resolution of 0.04 nm.

  15. Fabrication and materials for magneto-photonic assemblies for high-gain antenna applications at GHz frequencies

    NASA Astrophysics Data System (ADS)

    Zhang, Lanlin

    Recent magnetic photonic assembly (MPA) designs for high-gain antennas contain arrays of low-loss, anisotropic dielectrics and ferrimagnetic materials. Anisotropic dielectrics (AD) are fabricated from laminates, which consist of two ceramics with largely different permittivity and low dielectric losses at GHz frequencies. High gain has been demonstrated in a prototype antenna with 2 sets of 3 mutually rotated AD layers. These layers were made from laminates of commercially available alpha-Al2O3 and Nd-doped barium titanate. Equivalent permittivity tensors and loss tangents (tan delta˜1.9x10-3) were characterized using a resonant cavity based approach, coupled with a finite-element method (FEM) full-wave solver. To enable further minimization of dielectric loss (tan delta), dense high-purity alpha-Al2O3 and TiO2 were prepared starting from colloidally stabilizing the powders in aqueous HNO3 or NH3. After colloidal filtration and sintering, alpha-Al 2O3 with >97.9% density was achieved at a sintering temperature of 1300°C, and TiO2 with >99.5% density was obtained at 1000°C. These low sintering temperatures are ascribed to excellent compact homogeneity. TiO2 was obtained with tan delta of 1.4x10-4 at 6.4 GHz at room temperature. This relatively low value is attributed to the homogeneous dense microstructure with 2.2 mum grain size. Al 3+ was doped into TiO2 using a modified infiltration method to compensate for the effect of Ti4+ reduction. A homogeneous microstructure and doping concentration were also observed in the doped dense TiO2. Substituted Y3Fe5O12 (YIG) garnet was chosen as the ferrimagnetic (F) component, due to its pronounced Faraday rotation effect and potentially low magnetic and dielectric loss. Phase pure garnet was prepared by using the citric-gel method. The magnetic properties were studied for Ca,V,Zr-substituted YIG (CVZG) and as-prepared particle morphology. Compacts of CVZG submicron particles were found to possess a low loss at GHz

  16. Powerful linearly-polarized high-order random fiber laser pumped by broadband amplified spontaneous emission source

    NASA Astrophysics Data System (ADS)

    Xu, Jiangming; Zhou, Pu; Leng, Jinyong; Wu, Jian; Zhang, Hanwei

    2016-10-01

    A great deal of attention has been drawn to Random fiber lasers (RFLs) for their typical features of modeless, cavity-less and low coherence length. However, most previously reported high power RFLs employ narrowband fiber lasers as the pump source, thus inducing the self-pulsing transferring from pump source to output Stokes. In this contribution, linearly-polarized RFL pumped by broadband amplified-spontaneous-emission (ASE) is demonstrated and continuous-wave (CW) high order Stokes can be obtained.With 30.6 W pump injected into the half-opened cavity, 23.51 W the 2nd order Stokes centered at 1178 nm with a full width at half-maximum linewidth of 1.73 nm and polarization extinction ratio of about 25 dB can be obtained. The standard deviation and peak-vale value of the 2nd order Stokes light at maximal output power is just 0.47% and 4.10%, which indicates the good power stability. Significantly, the corresponding quantum efficiency of the 1st and 2nd order Stokes light is about 87% and 85%, and almost all pump photons are converted into Stokes photons. As far as we know, it is the highest power ever reported from linearly polarized RFL, and further power scaling is available in the case of more powerful pump source and optimization of system parameters.

  17. Powerful linearly-polarized high-order random fiber laser pumped by broadband amplified spontaneous emission source

    PubMed Central

    Xu, Jiangming; Zhou, Pu; Leng, Jinyong; Wu, Jian; Zhang, Hanwei

    2016-01-01

    A great deal of attention has been drawn to Random fiber lasers (RFLs) for their typical features of modeless, cavity-less and low coherence length. However, most previously reported high power RFLs employ narrowband fiber lasers as the pump source, thus inducing the self-pulsing transferring from pump source to output Stokes. In this contribution, linearly-polarized RFL pumped by broadband amplified-spontaneous-emission (ASE) is demonstrated and continuous-wave (CW) high order Stokes can be obtained.With 30.6 W pump injected into the half-opened cavity, 23.51 W the 2nd order Stokes centered at 1178 nm with a full width at half-maximum linewidth of 1.73 nm and polarization extinction ratio of about 25 dB can be obtained. The standard deviation and peak-vale value of the 2nd order Stokes light at maximal output power is just 0.47% and 4.10%, which indicates the good power stability. Significantly, the corresponding quantum efficiency of the 1st and 2nd order Stokes light is about 87% and 85%, and almost all pump photons are converted into Stokes photons. As far as we know, it is the highest power ever reported from linearly polarized RFL, and further power scaling is available in the case of more powerful pump source and optimization of system parameters. PMID:27725759

  18. The Use of Group Activities in Introductory Biology Supports Learning Gains and Uniquely Benefits High-Achieving Students.

    PubMed

    Marbach-Ad, Gili; Rietschel, Carly H; Saluja, Neeti; Carleton, Karen L; Haag, Eric S

    2016-12-01

    This study describes the implementation and effectiveness of small-group active engagement (GAE) exercises in an introductory biology course (BSCI207) taught in a large auditorium setting. BSCI207 (Principles of Biology III-Organismal Biology) is the third introductory core course for Biological Sciences majors. In fall 2014, the instructors redesigned one section to include GAE activities to supplement lecture content. One section (n = 198) employed three lectures per week. The other section (n = 136) replaced one lecture per week with a GAE class. We explored the benefits and challenges associated with implementing GAE exercises and their relative effectiveness for unique student groups (e.g., minority students, high- and low-grade point average [GPA] students). Our findings show that undergraduates in the GAE class exhibited greater improvement in learning outcomes than undergraduates in the traditional class. Findings also indicate that high-achieving students experienced the greatest benefit from GAE activities. Some at-risk student groups (e.g., two-year transfer students) showed comparably low learning gains in the course, despite the additional support that may have been afforded by active learning. Collectively, these findings provide valuable feedback that may assist other instructors who wish to revise their courses and recommendations for institutions regarding prerequisite coursework approval policies.

  19. The Use of Group Activities in Introductory Biology Supports Learning Gains and Uniquely Benefits High-Achieving Students†

    PubMed Central

    Marbach-Ad, Gili; Rietschel, Carly H.; Saluja, Neeti; Carleton, Karen L.; Haag, Eric S.

    2016-01-01

    This study describes the implementation and effectiveness of small-group active engagement (GAE) exercises in an introductory biology course (BSCI207) taught in a large auditorium setting. BSCI207 (Principles of Biology III—Organismal Biology) is the third introductory core course for Biological Sciences majors. In fall 2014, the instructors redesigned one section to include GAE activities to supplement lecture content. One section (n = 198) employed three lectures per week. The other section (n = 136) replaced one lecture per week with a GAE class. We explored the benefits and challenges associated with implementing GAE exercises and their relative effectiveness for unique student groups (e.g., minority students, high- and low-grade point average [GPA] students). Our findings show that undergraduates in the GAE class exhibited greater improvement in learning outcomes than undergraduates in the traditional class. Findings also indicate that high-achieving students experienced the greatest benefit from GAE activities. Some at-risk student groups (e.g., two-year transfer students) showed comparably low learning gains in the course, despite the additional support that may have been afforded by active learning. Collectively, these findings provide valuable feedback that may assist other instructors who wish to revise their courses and recommendations for institutions regarding prerequisite coursework approval policies. PMID:28101262

  20. Serotypes not Included in 13-Valent Pneumococcal Vaccine as Causes of Acute Otitis Media with Spontaneous Tympanic Membrane Perforation in a Geographic Area with High Vaccination Coverage.

    PubMed

    Marchisio, Paola; Esposito, Susanna; Picca, Marina; Baggi, Elena; Terranova, Leonardo; Orenti, Annalisa; Biganzoli, Elia; Principi, Nicola

    2016-12-15

    In 177 children living in an area with high 13-valent pneumococcal conjugate vaccine (PCV13) coverage who had acute otitis media (AOM) complicated with spontaneous tympanic membrane perforation (STMP), Streptococcus pneumoniae was identified in the middle ear fluid of 48 (27.1%) subjects, with 37 (77.1%) cases caused by non-PCV13 serotypes.

  1. Do High-Functioning People with Autism Spectrum Disorder Spontaneously Use Event Knowledge to Selectively Attend to and Remember Context-Relevant Aspects in Scenes?

    ERIC Educational Resources Information Center

    Loth, Eva; Gomez, Juan Carlos; Happe, Francesca

    2011-01-01

    This study combined an event schema approach with top-down processing perspectives to investigate whether high-functioning children and adults with autism spectrum disorder (ASD) spontaneously attend to and remember context-relevant aspects of scenes. Participants read one story of story-pairs (e.g., burglary or tea party). They then inspected a…

  2. Consumption of a high-fat diet abrogates inhibitory effects of methylseleninic acid on spontaneous metastasis of Lewis lung carcinoma in mice

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We investigated the effect of dietary supplementation with selenium (Se) on spontaneous metastasis of Lewis lung carcinoma (LLC) in male C57BL/6 mice fed a high-fat diet. Mice were fed the AIN93G diet or that diet modified with 45% calories from fat supplemented with or without 2.5 mg Se/4029 kCal ...

  3. Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We investigated the effects of plasminogen activator inhibitor-1 (PAI-1) deficiency on spontaneous metastasis of Lewis lung carcinoma (LLC) in PAI-1 deficient (PAI-1-/-) and wildtype mice (C57BL/6J background) fed the AIN93G diet or that diet modified with 45% calories from fat. The high-fat diet i...

  4. High-temperature molecular magnets based on cyanovanadate building blocks: spontaneous magnetization at 230 k.

    PubMed

    Entley, W R; Girolami, G S

    1995-04-21

    The molecular-based magnetic materials Cs(2)Mn(||)[V(||)(CN)(6)] (1) and (Et(4)N)(0.5)Mn(l.25)- [V(CN)(5)].2H(2)O (2) (where Et is ethyl) were prepared by the addition of manganese(II) triflate to aqueous solutions of the hexacyanovanadate(II) ion at 0 degrees C. Whereas 1 crystallizes in a face-centered cubic lattice, 2 crystallizes in a noncubic space group. The cesium salt (1) has features characteristic of a three-dimensional ferrimagnet with a Néel transition at 125 kelvin. The tetraethylammonium salt (2) also behaves as a three-dimensional ferrimagnet with a Néel temperature of 230 kelvin; only two other molecular magnets have higher magnetic ordering temperatures. Saturation magnetization measurements indicate that in both compounds the V(II) and high-spin Mn(II) centers are antiferromagnetically coupled. Both 1 and 2 exhibit hysteresis loops characteristic of soft magnets below their magnetic phase-transition temperatures. The high magnetic ordering temperatures of these cyano-bridged solids confirm that the incorporation of early transition elements into the lattice promotes stronger magnetic coupling by enhancing the backbonding into the cyanide pi* orbitals.

  5. Highly Transparent Dual-Sensitized Titanium Dioxide Nanotube Arrays for Spontaneous Solar Water Splitting Tandem Configuration.

    PubMed

    Shin, Kahee; Park, Jong Hyeok

    2015-08-26

    Vertically aligned one-dimensional (1D) titanium dioxide (TiO2) arrays on transparent conducting oxide (TCO) substrates, which can act as host electron transport materials for low bandgap materials, were synthesized via a hydrothermal reaction combined with a controlled chemical etching process. By controlling the chemical etching conditions, we can maximize the light transmission properties of the 1D TiO2 arrays, which is beneficial for the front electrode in photoelectrochemical (PEC) tandem configurations. As a result, dual sensitization to form 1D TiO2@CdS@CdSe (CdS and CdSe coated 1D TiO2) results in excellent photocurrent density, as well as transparency, and the resulting material is able to pass unabsorbed photons through the front electrode into the rear bias solar cell. Owing to the improved light transmission in combination with the increased specific surface area of the obtained 1D TiO2 arrays from the controlled etching process, a high-efficiency PEC tandem device with ∼2.1% was successfully fabricated for unassisted hydrogen evolution. Efficient PEC tandem device was fabricated for unassisted solar hydrogen generation using highly transparent composite electrode composed of dual sensitization to form 1D TiO2@CdS@CdSe.

  6. SPONTANEOUS CATALYTIC WET AIR OXIDATION DURING PRE-TREATMENT OF HIGH-LEVEL RADIOACTIVE WASTE SLUDGE

    SciTech Connect

    Koopman, D.; Herman, C.; Pareizs, J.; Bannochie, C.; Best, D.; Bibler, N.; Fellinger, T.

    2009-10-01

    Savannah River Remediation, LLC (SRR) operates the Defense Waste Processing Facility for the U.S. Department of Energy at the Savannah River Site. This facility immobilizes high-level radioactive waste through vitrification following chemical pretreatment. Catalytic destruction of formate and oxalate ions to carbon dioxide has been observed during qualification testing of non-radioactive analog systems. Carbon dioxide production greatly exceeded hydrogen production, indicating the occurrence of a process other than the catalytic decomposition of formic acid. Statistical modeling was used to relate the new reaction chemistry to partial catalytic wet air oxidation of both formate and oxalate ions driven by the low concentrations of palladium, rhodium, and/or ruthenium in the waste. Variations in process conditions led to increases or decreases in the total oxidative destruction, as well as partially shifting the preferred species undergoing destruction from oxalate ion to formate ion.

  7. Timing and amplitude jitter in a gain-switched multimode semiconductor laser

    NASA Astrophysics Data System (ADS)

    Wada, Kenji; Kitagawa, Naoaki; Matsukura, Satoru; Matsuyama, Tetsuya; Horinaka, Hiromichi

    2016-04-01

    The differences in timing jitter between a gain-switched single-mode semiconductor laser and a gain-switched multimode semiconductor laser are examined using rate equations that include Langevin noise. The timing jitter in a gain-switched multimode semiconductor laser is found to be effectively suppressed by a decrease in the coherence time of the amplified spontaneous emission (ASE) based on a broad bandwidth of multimode oscillation. Instead, fluctuations in the ASE cause amplitude jitter in the pulse components of the respective modes. A pulse train of gain-switched pulses from a multimode semiconductor laser with timing jitter is equivalently simulated by assuming a high spontaneous emission factor and a short coherence time of the ASE in the single-mode semiconductor laser rate equations.

  8. An indirect flat-panel detector with avalanche gain for low dose x-ray imaging: SAPHIRE (scintillator avalanche photoconductor with high resolution emitter readout)

    NASA Astrophysics Data System (ADS)

    Zhao, Wei; Li, Dan; Rowlands, J. A.; Egami, N.; Takiguchi, Y.; Nanba, M.; Honda, Y.; Ohkawa, Y.; Kubota, M.; Tanioka, K.; Suzuki, K.; Kawai, T.

    2008-03-01

    An indirect flat-imager with programmable avalanche gain and field emitter array (FEA) readout is being investigated for low-dose x-ray imaging with high resolution. It is made by optically coupling a structured x-ray scintillator CsI (Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The charge image created by HARP is read out by electron beams generated by the FEA. The proposed detector is called SAPHIRE (Scintillator Avalanche Photoconductor with HIgh Resolution Emitter readout). The avalanche gain of HARP depends on both a-Se thickness and applied electric field E Se. At E Se of > 80 V/μm, the avalanche gain can enhance the signal at low dose (e.g. fluoroscopy) and make the detector x-ray quantum noise limited down to a single x-ray photon. At high exposure (e.g. radiography), the avalanche gain can be turned off by decreasing E Se to < 70 V/μm. In this paper the imaging characteristics of the FEA readout method, including the spatial resolution and noise, were investigated experimentally using a prototype optical HARP-FEA image sensor. The potential x-ray imaging performance of SAPHIRE, especially the aspect of programmable gain to ensure wide dynamic range and x-ray quantum noise limited performance at the lowest exposure in fluoroscopy, was investigated.

  9. Spontaneous acute spinal subdural hematoma: spontaneous recovery from severe paraparesis--case report and review.

    PubMed

    Payer, Michael; Agosti, Reto

    2010-11-01

    Spontaneous idiopathic acute spinal subdural hematomas are highly exceptional. Neurological symptoms are usually severe, and rapid diagnosis with MRI is mandatory. Surgical evacuation has frequently been used therapeutically; however, spontaneous recovery in mild cases has also been reported. We present a case of spontaneous recovery from severe paraparesis after spontaneous acute SSDH, and review the English-speaking literature.

  10. Low- but Not High-Frequency LFP Correlates with Spontaneous BOLD Fluctuations in Rat Whisker Barrel Cortex

    PubMed Central

    Lu, Hanbing; Wang, Leiming; Rea, William W.; Brynildsen, Julia K.; Jaime, Saul; Zuo, Yantao; Stein, Elliot A.; Yang, Yihong

    2016-01-01

    Resting-state magnetic resonance imaging (rsMRI) is thought to reflect ongoing spontaneous brain activity. However, the precise neurophysiological basis of rsMRI signal remains elusive. Converging evidence supports the notion that local field potential (LFP) signal in the high-frequency range correlates with fMRI response evoked by a task (e.g., visual stimulation). It remains uncertain whether this relationship extends to rsMRI. In this study, we systematically modulated LFP signal in the whisker barrel cortex (WBC) by unilateral deflection of rat whiskers. Results show that functional connectivity between bilateral WBC was significantly modulated at the 2 Hz, but not at the 4 or 6 Hz, stimulus condition. Electrophysiologically, only in the low-frequency range (<5 Hz) was the LFP power synchrony in bilateral WBC significantly modulated at 2 Hz, but not at 4- or 6-Hz whisker stimulation, thus distinguishing these 2 experimental conditions, and paralleling the findings in rsMRI. LFP power synchrony in other frequency ranges was modulated in a way that was neither unique to the specific stimulus conditions nor parallel to the fMRI results. Our results support the hypothesis that emphasizes the role of low-frequency LFP signal underlying rsMRI. PMID:25331598

  11. Use of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA).

    PubMed

    Fragoso, Viviane Muniz da Silva; Hoppe, Luanda Yanaan; de Araújo-Jorge, Tânia Cremonini; de Azevedo, Marcos José; Campos, Jerônimo Diego de Souza; Cortez, Célia Martins; de Oliveira, Gabriel Melo

    2016-03-15

    Aggression is defined as the act in which an individual intentionally harms or injures another of their own species. Antipsychotics are a form of treatment used in psychiatric routine. They have been used for decades in treatment of patients with aggressive behavior. Haloperidol and risperidone promote the control of psychiatric symptoms, through their respective mechanisms of action. Experimental models are obtained by behavioral, genetic, and pharmacological manipulations, and use a reduced number of animals. In this context, we applied the model of spontaneous aggression (MSA), originating the presence of highly aggressive mice (AgR) when reassembled in adulthood. We administered haloperidol and risperidone in escalating doses, for ten consecutive days. Using positive and negative control groups, we evaluated the effectiveness of these drugs and the reversal of the aggressive behavior, performing the tail suspension test (TST) and open field test (OFT) on 10th day of treatment and 10 days after its discontinuation. The results showed that both antipsychotic drugs were effective in AgR and reversed the aggressive phenotype, reducing the number of attacks by AgR and the extent of lesions in the subordinate mice (AgD) exposed to the pattern of aggressive behavior (PAB) of the aggressors. This conclusion is based on the reduction in the animals' motor and exploratory activity, and on the reversal of patterns of aggressive behavior. The association between the MSA and experiments with other therapeutic protocols and different antipsychotics can be an important methodology in the study of aggressive behavior in psychiatric patients.

  12. Fast Ionic Diffusion-Enabled Nanoflake Electrode by Spontaneous Electrochemical Pre-Intercalation for High-Performance Supercapacitor

    PubMed Central

    Mai, Liqiang; Li, Han; Zhao, Yunlong; Xu, Lin; Xu, Xu; Luo, Yanzhu; Zhang, Zhengfei; Ke, Wang; Niu, Chaojiang; Zhang, Qingjie

    2013-01-01

    Layered intercalation compounds NaxMnO2 (x = 0.7 and 0.91) nanoflakes have been prepared directly through wet electrochemical process with Na+ ions intercalated into MnO2 interlayers spontaneously. The as-prepared NaxMnO2 nanoflake based supercapacitors exhibit faster ionic diffusion with enhanced redox peaks, tenfold-higher energy densities up to 110 Wh·kg−1 and higher capacitances over 1000 F·g−1 in aqueous sodium system compared with traditional MnO2 supercapacitors. Due to the free-standing electrode structure and suitable crystal structure, NaxMnO2 nanoflake electrodes also maintain outstanding electrochemical stability with capacitance retention up to 99.9% after 1000 cycles. Besides, pre-intercalation effect is further studied to explain this enhanced electrochemical performance. This study indicates that the suitable pre-intercalation is effective to improve the diffusion of electrolyte cations and other electrochemical performance for layered oxides, and suggests that the as-obtained nanoflakes are promising materials to achieve the hybridization of both high energy and power density for advanced supercapacitors.

  13. Quantitative Analysis of Spectral Interference of Spontaneous Raman Scattering in High-Pressure Fuel-Rich H2-Air Combustion

    NASA Technical Reports Server (NTRS)

    Kojima, Jun; Nguyen, Quang-Viet

    2004-01-01

    We present a theoretical study of the spectral interferences in the spontaneous Raman scattering spectra of major combustion products in 30-atm fuel-rich hydrogen-air flames. An effective methodology is introduced to choose an appropriate line-shape model for simulating Raman spectra in high-pressure combustion environments. The Voigt profile with the additive approximation assumption was found to provide a reasonable model of the spectral line shape for the present analysis. The rotational/vibrational Raman spectra of H2, N2, and H2O were calculated using an anharmonic-oscillator model using the latest collisional broadening coefficients. The calculated spectra were validated with data obtained in a 10-atm fuel-rich H2-air flame and showed excellent agreement. Our quantitative spectral analysis for equivalence ratios ranging from 1.5 to 5.0 revealed substantial amounts of spectral cross-talk between the rotational H2 lines and the N2 O-/Q-branch; and between the vibrational H2O(0,3) line and the vibrational H2O spectrum. We also address the temperature dependence of the spectral cross-talk and extend our analysis to include a cross-talk compensation technique that removes the nterference arising from the H2 Raman spectra onto the N2, or H2O spectra.

  14. High-power, variable repetition rate, picosecond optical parametric oscillator pumped by an amplified gain-switched diode.

    PubMed

    Kienle, Florian; Chen, Kang K; Alam, Shaif-Ul; Gawith, Corin B E; Mackenzie, Jacob I; Hanna, David C; Richardson, David J; Shepherd, David P

    2010-04-12

    We demonstrate a picosecond optical parametric oscillator (OPO) that is synchronously pumped by a fiber-amplified gain-switched laser diode. At 24W of pump power, up to 7.3W at 1.54microm and 3.1W at 3.4microm is obtained in separate output beams. The periodically poled MgO-doped LiNbO(3) OPO operates with ~17ps pulses at a fundamental repetition rate of 114.8MHz but can be switched to higher repetition rates up to ~1GHz. Tunabilty between 1.4microm and 1.7microm (signal) and 2.9microm and 4.4microm (idler) is demonstrated by translating the nonlinear crystal to access different poling-period gratings and typical M(2) values of 1.1 by 1.2 (signal) and 1.6 by 3.2 (idler) are measured at high power for the singly resonant oscillator.

  15. Sensor fault detection and isolation via high-gain observers: application to a double-pipe heat exchanger.

    PubMed

    Escobar, R F; Astorga-Zaragoza, C M; Téllez-Anguiano, A C; Juárez-Romero, D; Hernández, J A; Guerrero-Ramírez, G V

    2011-07-01

    This paper deals with fault detection and isolation (FDI) in sensors applied to a concentric-pipe counter-flow heat exchanger. The proposed FDI is based on the analytical redundancy implementing nonlinear high-gain observers which are used to generate residuals when a sensor fault is presented (as software sensors). By evaluating the generated residual, it is possible to switch between the sensor and the observer when a failure is detected. Experiments in a heat exchanger pilot validate the effectiveness of the approach. The FDI technique is easy to implement allowing the industries to have an excellent alternative tool to keep their heat transfer process under supervision. The main contribution of this work is based on a dynamic model with heat transfer coefficients which depend on temperature and flow used to estimate the output temperatures of a heat exchanger. This model provides a satisfactory approximation of the states of the heat exchanger in order to allow its implementation in a FDI system used to perform supervision tasks.

  16. Low noise, low heat dissipation, high gain AC-DC front end amplification for scanning probe microscopy.

    PubMed

    Messina, Paolo; Fradin, F Y; Pittana, Paolo

    2009-02-04

    We report here on the design, construction and testing of a vacuum compatible AC-DC amplification system for low signal measurements with scanning probes. The most important feature of this new amplification system is incorporated within the head of a scanning tunneling microscope (STM). This is achieved with a very low thermal dissipation radio frequency amplifier at the STM head. The amplifier gain is higher than 40 dB and has a 50 dB maximum. Further, the AC noise figure is 0.7 dB between 100 and 1000 MHz. The noise induced in the DC amplifier is less than 2 pA RMS (root mean square), which enables the microscope to scan over soft insulating molecular layers. Thermal drift at the STM tip-sample interface is below 0.1 nm min(-1) both in air and in vacuum operation. Atomic resolution on highly oriented pyrolytic graphite surfaces is reliably achieved. Spin noise measurements are provided as an example of an application.

  17. Low noise, low heat dissipation, high gain AC-DC front end amplification for scanning probe microscopy.

    SciTech Connect

    Messina, P.; Fradin, F. Y.; Pittana, P.

    2009-01-01

    We report here on the design, construction and testing of a vacuum compatible AC-DC amplification system for low signal measurements with scanning probes. The most important feature of this new amplification system is incorporated within the head of a scanning tunneling microscope (STM). This is achieved with a very low thermal dissipation radio frequency amplifier at the STM head. The amplifier gain is higher than 40 dB and has a 50 dB maximum. Further, the AC noise figure is 0.7 dB between 100 and 1000 MHz. The noise induced in the DC amplifier is less than 2 pA RMS (root mean square), which enables the microscope to scan over soft insulating molecular layers. Thermal drift at the STM tip-sample interface is below 0.1 nm min{sup -1} both in air and in vacuum operation. Atomic resolution on highly oriented pyrolytic graphite surfaces is reliably achieved. Spin noise measurements are provided as an example of an application.

  18. Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice.

    PubMed

    Kim, Jangseon; Kim, Mi Hye; Choi, You Yeon; Hong, Jongki; Yang, Woong Mo

    2016-07-01

    Leonurus sibiricus, also called motherwort, is a well-known functional food and medicinal herb. It has been known to possess beneficial properties for women's health, especially for aged women. Estrogen deficiency in the menopause could induce lipid metabolic abnormalities in body fat, resulting in obesity. In this study, the inhibitory effects of L. sibiricus on obesity after the menopause were investigated. Female C57BL/6 mice were ovariectomized and fed high-fat diet (HFD) for 12 weeks. Following an induction period, aqueous extracts of L. sibiricus (LS) were orally administrated for 6 weeks. The body, uterine, and visceral fat weights were measured immediately after the animals were killed. Histological analysis was performed to monitor fat and liver. Serum levels of glucose, triglyceride, total cholesterol, and LDL-cholesterol were evaluated. In addition, the expression of lipases was analyzed. Total body weight was significantly decreased by LS treatment. Histological changes in adipocyte size were shown along with a decrease of visceral fat weight in the LS-treated group. In addition, the fat infiltration of liver was reduced by LS administration. LS-treated mice experienced decreases of serum triglyceride, total cholesterol, and LDL-cholesterol levels. The expression of HSL and ATGL was significantly increased by LS treatment. These results suggest that LS could regulate the lipid metabolism via an increase of lipases expression in ovariectomized and HFD-fed mice. LS might be a novel candidate for a functional food to inhibit weight gain after the menopause.

  19. Spontaneous fulminant gas gangrene.

    PubMed

    Delbridge, M S; Turton, E P L; Kester, R C

    2005-07-01

    Gas gangrene is a rare condition, usually associated with contaminated traumatic injuries. It carries a high rate of mortality and morbidity. A number of studies have implicated non-traumatic gas gangrene and colonic neoplasia. This paper reports a patient who presented spontaneously with Clostridium septicum gas gangrene and an occult caecal carcinoma.

  20. High-gain power recycling of a Fabry-Perot Michelson interferometer for a gravitational-wave antenna.

    PubMed

    Sato, S; Ohashi, M; Fujimoto, M K; Fukushima, M; Waseda, K; Miyoki, S; Mavalvala, N; Yamamoto, H

    2000-09-01

    Power recycling was implemented on a fully suspended prototype interferometer with arm lengths of 20 m. A wave-front-sensing technique for alignment control of the suspended mirrors was also implemented, which allowed for several hours of stable operation. A power-recycling gain of greater than 12 was achieved, a significant increase over the highest gain in a suspended mirror Fabry-Perot Michelson interferometer reported to date.

  1. Spontaneous cooperation for prosocials, but not for proselfs: Social value orientation moderates spontaneous cooperation behavior.

    PubMed

    Mischkowski, Dorothee; Glöckner, Andreas

    2016-02-15

    Cooperation is essential for the success of societies and there is an ongoing debate whether individuals have therefore developed a general spontaneous tendency to cooperate or not. Findings that cooperative behavior is related to shorter decision times provide support for the spontaneous cooperation effect, although contrary results have also been reported. We show that cooperative behavior is better described as person × situation interaction, in that there is a spontaneous cooperation effect for prosocial but not for proself persons. In three studies, one involving population representative samples from the US and Germany, we found that cooperation in a public good game is dependent on an interaction between individuals' social value orientation and decision time. Increasing deliberation about the dilemma situation does not affect persons that are selfish to begin with, but it is related to decreasing cooperation for prosocial persons that gain positive utility from outcomes of others and score high on the related general personality trait honesty/humility. Our results demonstrate that the spontaneous cooperation hypothesis has to be qualified in that it is limited to persons with a specific personality and social values. Furthermore, they allow reconciling conflicting previous findings by identifying an important moderator for the effect.

  2. Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet.

    PubMed

    Snoussi, Chahira; Ducroc, Robert; Hamdaoui, Mohamed Hédi; Dhaouadi, Karima; Abaidi, Houda; Cluzeaud, Francoise; Nazaret, Corinne; Le Gall, Maude; Bado, André

    2014-05-01

    Green tea containing polyphenols exerts antidiabetic and antiobesity effects, but the mechanisms involved are not fully understood. In this study, we first analyzed and compared polyphenol compounds [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in decoction of green tea leaves versus usual green tea extracts. Second, the effects of acute (30 min) or chronic (6 weeks) oral administration of green tea decoction (GTD) on intestinal glucose absorption were studied in vitro in Ussing chamber, ex vivo using isolated jejunal loops and in vivo through glucose tolerance tests. Finally, we explore in rat model fed normal or high-fat diet the effects of GTD on body weight, blood parameters and on the relative expression of glucose transporters SGLT-1, GLUT2 and GLUT4. GTD cooked for 15 min contained the highest amounts of phenolic compounds. In fasted rats, acute administration of GTD inhibited SGLT-1 activity, increased GLUT2 activity and improved glucose tolerance. Similarly to GTD, acute administration of synthetic phenolic compounds (2/3 EGCG+1/3 EGC) inhibited SGLT-1 activity. Chronic administration of GTD in rat fed high-fat diet reduced body weight gain, circulating triglycerides and cholesterol and improved glucose tolerance. GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa. Moreover, adipose tissue GLUT4 mRNA levels were increased. These results indicate that GTD, a traditional beverage rich in EGCG and EGC reduces intestinal SGLT-1/GLUT2 ratio, a hallmark of regulation of glucose absorption in enterocyte, and enhances adipose GLUT4 providing new insights in its possible role in the control of glucose homeostasis.

  3. NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats.

    PubMed

    She, Meihua; Deng, Xiaojian; Guo, Zhenyu; Laudon, Moshe; Hu, Zhuowei; Liao, Duanfang; Hu, Xiaobo; Luo, Yi; Shen, Qingyun; Su, Zehong; Yin, Weidong

    2009-04-01

    Evidences indicate that a complex relationship exists among sleep disorders, obesity and insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. In this study, we applied NEU-P11 on obese rats to assess its potential melatoninergic effects in vivo. Obese models were established using high-fat/high-sucrose-fed for 5 months. NEU-P11 (10mg/kg)/melatonin (4mg/kg)/vehicle were administered by a daily intraperitoneal injection respectively for 8 weeks. Our results showed that NEU-P11 or melatonin inhibited both body weight gain and deposit of abdominal fat with no influence on food intake. The impaired insulin sensitivity and antioxidative potency were improved and the levels of plasma glucose, total cholesterol (TC), triglycerides (TG) decreased with an increased in HDL-cholesterol (HDL-c) after NEU-P11 or melatonin administration. These data suggest that NEU-P11, like melatonin, decreased body weight gain and improved insulin sensitivity and metabolic profiles in obese rats. We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity.

  4. Bifunctional star-burst amorphous molecular materials for OLEDs: achieving highly efficient solid-state luminescence and carrier transport induced by spontaneous molecular orientation.

    PubMed

    Kim, Jun Yun; Yasuda, Takuma; Yang, Yu Seok; Adachi, Chihaya

    2013-05-21

    Bifunctional star-burst amorphous molecular materials displaying both efficient solid-state luminescence and high hole-transport properties are developed in this study. A high external electroluminescence quantum efficiency up to 5.9% is attained in OLEDs employing the developed amorphous materials. It is revealed that the spontaneous horizontal orientation of these light-emitting molecules in their molecular-condensed states leads to a remarkable enhancement of the electroluminescence efficiencies and carrier-transport properties.

  5. Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet.

    PubMed

    Nojima, Koji; Sugimoto, Ken; Ueda, Hironori; Babaya, Naru; Ikegami, Hiroshi; Rakugi, Hiromi

    2013-01-01

    Both genetic factors and diabetogenic environmental factors, such as a high-sucrose diet (HSD), are involved in the development of type 2 diabetes. In this study, the Nagoya-Shibata-Yasuda (NSY) mouse, an animal model of type 2 diabetes and C3H mice used as controls, were fed a HSD, a high-fat diet (HFD) or a regular diet (RD) from weaning. In C3H mice, HFD significantly increased body weight gain, but maintained glucose tolerance. In contrast, in NSY mice, HSD resulted in increased body weight gain and liver steatosis and increased glucose intolerance to a greater extent than HFD. Furthermore, we performed DNA microarray analysis to detect differences in hepatic gene expression levels in both strains under HSD. We then performed RT-PCR analysis on selected genes to evaluate basal expression level under RD and changes under HSD conditions. HSD-fed NSY, but not C3H mice, exhibited increased hepatic expression levels of Pparg2, an isoform of Pparg as well as G0s2, a target of Pparg, which are known to be adipocyte-specific genes. Compared to RD-fed C3H mice, hepatic expression levels of Kat2b (transcriptional regulation), Hsd3b5 (steroid hormone metabolism) and Cyp7b1 (bile acid metabolism) were initially lower in RD-fed NSY mice, and were further decreased in HSD-fed NSY mice. Expression of Metallothionein (Mt1) and Metallothionein 2 (Mt2) was significantly lower in NSY mice compared to C3H mice, irrespective of dietary condition. These data suggest that elucidation of this heterogeneity in response to HSD might contribute to further understanding of the gene-environment interactions leading to diabetes in humans.

  6. The X-Target: A novel high gain target with single-sided heavy-ion beam illumination

    NASA Astrophysics Data System (ADS)

    Henestroza, Enrique

    2012-10-01

    A new inertial-fusion target configuration, the X-target, using one-sided heavy ion axial illumination has been explored [1]. It takes advantage of the unique energy deposition properties of heavy ion beams that have a classical, long penetration range. This class of target uses heavy ion beams to compress and ignite deuterium-tritium (DT) fuel that fills the interior of metal cases that have side-view cross sections in the shape of an ``X''. X-targets that incorporate inside the case a propellant (plastic) and a pusher (aluminum) surrounding the DT are capable of assembling fuel areal densities ˜2 g/cm^2 using two MJ-scale annular beams to implode quasi-spherically the target to peak DT densities ˜100 g/cm^3. A 3MJ fast-ignition solid ion beam heats the fuel to thermonuclear temperatures in ˜200 ps to start the burn propagation, obtaining gains of ˜300. The main concern for the X-target is the amount of high-Z atomic mixing at the ignition zone produced by hydro-instabilities, which, if large enough, could cool the fuel during the ignition process and prevent the propagation of the fusion burn. Analytic estimates and implosion calculations using the radiation hydrodynamics code HYDRA in 2D (RZ), at typical Eulerian mesh resolutions of a few microns, have shown that for the relatively low implosion velocities, low stagnation fuel densities, and low quasi-spherical fuel convergence ratios of the X-target, these hydro-instabilities do not have a large effect on the burning process. These preliminary studies need to be extended by further hydrodynamic calculations using finer resolution, complemented with turbulent mix modeling and validated by experiments, to ascertain the stability of the X-target design. We will present the current status of the X-target. [4pt] [1] E. Henestroza and B. G. Logan, Phys. Plasmas 19, 072706 (2012)

  7. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.

    PubMed

    Jornayvaz, François R; Jurczak, Michael J; Lee, Hui-Young; Birkenfeld, Andreas L; Frederick, David W; Zhang, Dongyang; Zhang, Xian-Man; Samuel, Varman T; Shulman, Gerald I

    2010-11-01

    Low-carbohydrate, high-fat ketogenic diets (KD) have been suggested to be more effective in promoting weight loss than conventional caloric restriction, whereas their effect on hepatic glucose and lipid metabolism and the mechanisms by which they may promote weight loss remain controversial. The aim of this study was to explore the role of KD on liver and muscle insulin sensitivity, hepatic lipid metabolism, energy expenditure, and food intake. Using hyperinsulinemic-euglycemic clamps, we studied insulin action in mice fed a KD or regular chow (RC). Body composition was assessed by ¹H magnetic resonance spectroscopy. Despite being 15% lighter (P < 0.001) than RC-fed mice because of a 17% increase in energy expenditure (P < 0.001), KD-fed mice manifested severe hepatic insulin resistance, as reflected by decreased suppression (0% vs. 100% in RC-fed mice, P < 0.01) of endogenous glucose production during the clamp. Hepatic insulin resistance could be attributed to a 350% increase in hepatic diacylglycerol content (P < 0.001), resulting in increased activation of PKCε (P < 0.05) and decreased insulin receptor substrate-2 tyrosine phosphorylation (P < 0.01). Food intake was 56% (P < 0.001) lower in KD-fed mice, despite similar caloric intake, and could partly be attributed to a more than threefold increase (P < 0.05) in plasma N-acylphosphatidylethanolamine concentrations. In conclusion, despite preventing weight gain in mice, KD induces hepatic insulin resistance secondary to increased hepatic diacylglycerol content. Given the key role of nonalcoholic fatty liver disease in the development of type 2 diabetes and the widespread use of KD for the treatment of obesity, these results may have potentially important clinical implications.

  8. Gaining Acceptance

    ERIC Educational Resources Information Center

    Villano, Matt

    2007-01-01

    Back in the 1990s, when Bill Clinton was president and the internet was still a novelty, college recruitment was remarkably low-tech. Most prospective students visited high school guidance offices, wrote away for information about schools, attended college fairs, and visited campuses they were considering. Most admissions and recruiting activities…

  9. INTERNATIONAL CONFERENCE ON SEMICONDUCTOR INJECTION LASERS SELCO-87: Behavior of gain-guided lasers generating high-power nanosecond pulses

    NASA Astrophysics Data System (ADS)

    Erbert, G.

    1988-11-01

    Computer-controlled apparatus was used in an investigation of gain-guided narrow-stripe AlGaAs double heterostructure lasers. These lasers were excited with current pulses of 10 ns duration and amplitudes up to 3 A. The watt-ampere characteristics together with near- and far-field radiation patterns were considered using an analytic model of the lasers. The results showed that the values of the gain under a stripe contact or of the absorption outside this region varied with the output power.

  10. Spontaneous Remission of an Untreated, MYC and BCL2 Coexpressing, High-Grade B-Cell Lymphoma: A Case Report and Literature Review

    PubMed Central

    Potts, D. Alan; Fromm, Jonathan R.; Gopal, Ajay K.

    2017-01-01

    Non-Hodgkin lymphomas (NHL) are a heterogeneous group of hematologic malignancies typically treated with multiagent chemotherapy. Rarely, spontaneous remissions can be observed, particularly in more indolent subtypes. The prognosis of aggressive NHL can be predicted using clinical and histopathologic factors. In aggressive B-cell NHL, the importance of MYC and BCL2 proto-oncogene coexpression (as assessed by immunohistochemistry) and high-grade histologic features are particularly noteworthy. We report a unique case of spontaneous remission in a patient with an aggressive B-cell NHL which harbored high-risk histopathologic features, including MYC protein expression at 70–80%, BCL2 protein expression, and morphologic features suggestive of high-grade B-cell lymphoma, NOS (formerly B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [BCLU]). After undergoing a biopsy to confirm this diagnosis, he opted to forego curative-intent chemotherapy. The single, yet relatively large area of involvement noted on 18F-fluorodeoxyglucose positron emission tomography-computed tomography steadily resolved on subsequent follow-up studies. He remained without evidence of recurrence one year later, having never received treatment. This case emphasizes the potential for spontaneous remission in NHL and demonstrates that this phenomenon can be observed despite contemporary high-risk histopathologic features. PMID:28321348

  11. Establishment of an animal model of spontaneous cervical lymph node metastasis of laryngeal squamous cell carcinoma and obtaining laryngocarcinoma cells with high metastatic potential.

    PubMed

    Chen, L W; Wang, J L; Zhang, L Y; Yang, S M; Li, C S; Yu, N; Zhao W, J D; Zhao, L D; Li, K; Liu, M B; Zhai, S Q

    2013-01-01

    To establish an animal model of spontaneous cervical lymph node metastasis of laryngeal squamous cell carcinoma and obtain laryngocarcinoma cells with high metastatic potential, laryngeal squamous cell carcinoma cell line HEP-2 in logarithmic phase were inoculated under the lingual margin mucosa of nude mice. HEP-2 cells metastasized to the cervical lymph nodes were isolated, cultured, and re-inoculated under the lingual margin mucosa of nude mice twice. The tumor formation in the tongue and in the cervical lymph nodes was confirmed by pathological examination. Carcinoma cells' ability of invasion and migration was detected by transwell assay. Human specific Alu sequences were detected by PCR, which indicated that the tumor cells originated from human laryngeal squamous cell carcinoma cell line HEP-2. Finally, an animal model of spontaneous lymph node metastasis of laryngeal squamous cell carcinoma was successfully established. Laryngeal squamous cell carcinoma cells with high metastatic potential to lymph nodes were obtained through repeated inoculations. .

  12. Unilateral vestibular deafferentation (UVD) causes permanent asymmetry in the gain of the yaw VOR to high acceleration head impulses in guinea pigs.

    PubMed

    Curthoys, I S; Topple, A N; Halmagyi, G M

    1995-01-01

    Using an acute scleral search coil technique for measuring eye position in alert animals we have shown that after UVD the yaw VOR in the guinea pig shows a permanent gain asymmetry. There is a reduced gain during the first 100 ms of brief, high acceleration horizontal head rotations ("yaw head impulses") towards the operated side, but only a small loss in gain for similar rotations towards the intact side. This result confirms that the horizontal E response during the first 100 ms of an abrupt high acceleration head rotation is a clear indicator of the function of the horizontal canal. These results are similar to those in human patients after unilateral acoustic neuroma operations. The asymmetry in response is large shortly after UVD and decreases over time but is permanent.

  13. Spontaneous Coronary Artery Dissection

    MedlinePlus

    Spontaneous coronary artery dissection (SCAD) Overview By Mayo Clinic Staff Spontaneous coronary artery dissection — sometimes referred to as SCAD — is an ... the blood vessels in the heart. Spontaneous coronary artery dissection (SCAD) can slow or block blood flow ...

  14. High energy gain of trapped electrons in a tapered, diffraction-dominated inverse-free-electron laser.

    PubMed

    Musumeci, P; Tochitsky, S Ya; Boucher, S; Clayton, C E; Doyuran, A; England, R J; Joshi, C; Pellegrini, C; Ralph, J E; Rosenzweig, J B; Sung, C; Tolmachev, S; Travish, G; Varfolomeev, A A; Varfolomeev, A A; Yarovoi, T; Yoder, R B

    2005-04-22

    Energy gain of trapped electrons in excess of 20 MeV has been demonstrated in an inverse-free-electron-laser (IFEL) accelerator experiment. A 14.5 MeV electron beam is copropagated with a 400 GW CO2 laser beam in a 50 cm long undulator strongly tapered in period and field amplitude. The Rayleigh range of the laser, approximately 1.8 cm, is much shorter than the undulator length yielding a diffraction-dominated interaction. Experimental results on the dependence of the acceleration on injection energy, laser focus position, and laser power are discussed. Simulations, in good agreement with the experimental data, show that most of the energy gain occurs in the first half of the undulator at a gradient of 70 MeV/m and that the structure in the measured energy spectrum arises because of higher harmonic IFEL interaction in the second half of the undulator.

  15. High-gain inner-shell photoionization laser in Cd vapor pumped by soft-x-ray radiation from a laser-produced plasma source.

    PubMed

    Silfvast, W T; Macklin, J J; Ii, O R

    1983-11-01

    A soft-x-ray-pumped inner-shell photoionization laser has been produced in Cd vapor at 4416 and 3250 A. A gain of 5.6 cm(-1) has been measured at 4416 A, and a reasonably high-energy storage of 0.2 mJ/cm(3) in the upper laser states has been obtained.

  16. Temperature dependency of the Ga/In distribution in Cu(In,Ga)Se2 absorbers in high temperature processes

    NASA Astrophysics Data System (ADS)

    Mueller, B. J.; Demes, T.; Lill, P. C.; Haug, V.; Hergert, F.; Zweigart, S.; Herr, U.

    2016-05-01

    The current article reports about the influence of temperature and glass substrate on Ga/In interdiffusion and chalcopyrite phase formation in the stacked elemental layer process. According to the Shockley-Queisser limit the optimum for single junction devices is near 1.4 eV, which is strongly coupled on the Ga/(Ga+In) ratio of Cu(In,Ga)Se2 thin film solar cells. To increase the Ga content in the active region of the Cu(In,Ga)Se2 a 70:30 CuGa alloy target is used. An increase of the selenization temperature leads to a more homogeneous Ga/In distribution and a less pronounced Ga agglomeration at the back contact. The Ga/In interdiffusion rates for different selenization temperatures and substrates were estimated with the model of a two layer system. At the highest selenization temperature used an absorber band gap of 1.12 eV was realized, which is similar to typical values of absorbers produced during the co-evaporation process. The Na diffusion into the Cu(In,Ga)Se2 is weakly temperature dependent but strongly influenced by the choice of the glass substrate composition.

  17. Structure of the spontaneous emission spectra of high-{gamma} free electron lasers as measured at the Darmstadt (S-Dalinac) FEL

    SciTech Connect

    Renz, G.; Spindler, G.; Schlott, V.

    1995-12-31

    Recent spontaneous emission measurements at the Darmstadt infrared FEL indicate a relatively broad (down-shifted) spectrum with several intensity maxima. The typical features of the measured spectrum can be well reproduced by a numerical simulation comprising the 3-d electron dynamics in a realizable planar wiggler field, the spontaneous radiation according to the well-known Jackson formula, as well as the detection of the radiation with a finite aperture detector. An analytical consideration attributes the observed down-shift to the reduced Doppler up-shift of the radiation as observed under a finite angle with respect to the axis. The intensity peaks appear as a consequence of a modulation of the transverse velocity amplitudes of the electrons due to the betatron oscillation. The spectral spacing of these {open_quote}sidebands{close_quote} are roughly given by the Doppler up-shifted betatron frequency. Consequences for very high energy FELs will be discussed.

  18. Merged beam laser design for reduction of gain-saturation and two-photon absorption in high power single mode semiconductor lasers.

    PubMed

    Lysevych, M; Tan, H H; Karouta, F; Fu, L; Jagadish, C

    2013-04-08

    In this paper we report a method to overcome the limitations of gain-saturation and two-photon absorption faced by developers of high power single mode InP-based lasers and semiconductor optical amplifiers (SOA) including those based on wide-waveguide or slab-coupled optical waveguide laser (SCOWL) technology. The method is based on Y-coupling design of the laser cavity. The reduction in gain-saturation and two-photon absorption in the merged beam laser structures (MBL) are obtained by reducing the intensity of electromagnetic field in the laser cavity. Standard ridge-waveguide lasers and MBLs were fabricated, tested and compared. Despite a slightly higher threshold current, the reduced gain-saturation in MBLs results in higher output power. The MBLs also produced a single spatial mode, as well as a strongly dominating single spectral mode which is the inherent feature of MBL-type cavity.

  19. Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice.

    PubMed

    Wu, Tao; Qi, Xueming; Liu, Yan; Guo, Jun; Zhu, Ruiyu; Chen, Wei; Zheng, Xiaodong; Yu, Ting

    2013-11-01

    We present our experiment about adding anthocyanins to the daily food of mice. Three kinds of anthocyanins (cyanidin-3-glucoside, cyanidin-3-rutinoside and pelargonidin-3-glucoside) purified from Chinese mulberry (Morus australis Poir) were evaluated for suppressing body weight gain of the male C57BL/6 mice fed with high-fat diet (HFD). The results from a 12-week experiment show that consumption of purified mulberry anthocyanins (MACN) of 40 or 200mg/kg can significantly inhibit body weight gain, reduce the resistance to insulin, lower the size of adipocytes, attenuate lipid accumulation and decrease the leptin secretion. Thus, dietary supplementation with MACN can protect against body weight gain of the diet-induced obese mice.

  20. Highly effective and inexpensive parasitological technique for diagnosis of intestinal parasites in developing countries: spontaneous sedimentation technique in tube.

    PubMed

    Tello, Raúl; Terashima, Angélica; Marcos, Luis A; Machicado, Jorge; Canales, Marco; Gotuzzo, Eduardo

    2012-06-01

    Millions of low-income people in the world are affected by intestinal parasites. Inexpensive, simple, and effective techniques for diagnosis are necessary. The spontaneous sedimentation technique in tube (SSTT), for application in poor healthcare settings and under field-work conditions, was described 25 years ago in Peru by Tello. The advantages of the SSTT are its ability to detect the majority of intestinal parasites, including eggs, larvae, cysts, and trophozoites, and its low cost.

  1. Spontaneous spinal epidural abscess.

    PubMed

    Ellanti, P; Morris, S

    2011-10-01

    Spinal epidural abscess is an uncommon entity, the frequency of which is increasing. They occur spontaneously or as a complication of intervention. The classical triad of fever, back pain and neurological symptoms are not always present. High index of suspicion is key to diagnosis. Any delay in diagnosis and treatment can have significant neurological consequences. We present the case of a previously well man with a one month history of back pain resulting from an epidural abscess.

  2. Spontaneous baryogenesis without baryon isocurvature

    NASA Astrophysics Data System (ADS)

    De Simone, Andrea; Kobayashi, Takeshi

    2017-02-01

    We propose a new class of spontaneous baryogenesis models that does not produce baryon isocurvature perturbations. The baryon chemical potential in these models is independent of the field value of the baryon-generating scalar, hence the scalar field fluctuations are blocked from propagating into the baryon isocurvature. We demonstrate this mechanism in simple examples where spontaneous baryogenesis is driven by a non-canonical scalar field. The suppression of the baryon isocurvature allows spontaneous baryogenesis to be compatible even with high-scale inflation.

  3. Measurements of the Low Frequency Gain Fluctuations of a 30 GHz High-Electron-Mobility-Transistor Cryogenic Amplifier

    NASA Technical Reports Server (NTRS)

    Jarosik, Norman

    1994-01-01

    Low frequency gain fluctuations of a 30 GHz cryogenic HEMT amplifier have been measured with the input of the amplifier connected to a 15 K load. Effects of fluctuations of other components of the test set-up were eliminated by use of a power-power correlation technique. Strong correlation between output power fluctuations of the amplifier and drain current fluctuations of the transistors comprising the amplifier are observed. The existence of these correlations introduces the possibility of regressing some of the excess noise from the HEMT amplifier's output using the measured drain currents.

  4. Design of a high-gain laser diode-array pumped Nd:YAG alternating precessive slab amplifier (APS amplifier)

    NASA Technical Reports Server (NTRS)

    Coyle, D. B.

    1991-01-01

    In the design of space-qualifiable laser systems for ranging and altimetry, such as NASA's Geodynamic Laser Ranging System (GLRS), the transmitter must be kept small, powerful yet efficient, and must consist of as few components as possible. A novel preamplifier design is examined which requires no external beam steering optics, yielding a compact component with simple alignment procedures. The gains achieved are comparable to multipass zigzag amplifiers using two or more sets of external optics for extra passes through the amplifying medium.

  5. Improving proliferation resistance of high breeding gain generation 4 reactors using blankets composed of light water reactor waste

    SciTech Connect

    Hellesen, C.; Grape, S.; Haakanson, A.; Jacobson Svaerd, S.; Jansson, P.

    2013-07-01

    Fertile blankets can be used in fast reactors to enhance the breeding gain as well as the passive safety characteristics. However, such blankets typically result in the production of weapons grade plutonium. For this reason they are often excluded from Generation IV reactor designs. In this paper we demonstrate that using blankets manufactured directly from spent light water (LWR) reactor fuel it is possible to produce a plutonium product with non-proliferation characteristics on a par with spent LWR fuel of 30-50 MWd/kg burnup. The beneficial breeding and safety characteristics are retained. (authors)

  6. "Making it explicit" makes a difference: evidence for a dissociation of spontaneous and intentional level 1 perspective taking in high-functioning autism.

    PubMed

    Schwarzkopf, Sarah; Schilbach, Leonhard; Vogeley, Kai; Timmermans, Bert

    2014-06-01

    The ability of perspective taking is a fundamental aspect of social cognition. The ability to decide, what another person can or cannot see is referred to as "level 1 perspective taking." This is thought to be a process that we can make use of intentionally, but which also takes place spontaneously. Autism is characterized by impairments of social interaction, which are thought to be related to deficits in implicit rather than explicit perspective taking. In order to assess both levels of processing with regard to perspective taking, we employed an established task in patients and controls. Our results demonstrate that both groups engage in spontaneous level 1 perspective taking. In contrast to controls, however, patients reacted more slowly if they had to verify the other's as compared to their own perspective, which shows that participants with high-functioning autism have selective difficulties in explicit, but not implicit, level 1 perspective taking. These findings demonstrate that while spontaneous level 1 perspective taking appears to be intact in autism, this ability is impaired in patients when used explicitly.

  7. Very high-gain and low-excess noise near-infrared single-photon avalanche detector: an NIR solid state photomultiplier

    NASA Astrophysics Data System (ADS)

    Linga, Krishna; Yevtukhov, Yuriy; Liang, Bing

    2009-05-01

    A new family of photodetectors with a Discrete Amplification (DA) mechanism allows the realization of very high gain and low excess noise factor in the visible and near infrared spectral regions and offers an alternative to conventional photomultiplier tubes and Geiger mode avalanche photodetectors. These photodetectors can operate in linear detection mode with gain-bandwidth product in excess of 4X1014 and in photon counting mode with count rates up to 108 counts/sec. Potential benefits of this technology over conventional avalanche photodetectors include ultra low excess noise factor, very high gain, and lower reset time (<< 1 μs). In the photon counting mode, the devices can be operated in the non-gated mode under a constant dc bias. Because of its unique characteristics of self-quenching and self-recovery, no external quenching circuit is needed. We present the discrete amplification design approach used for the development of a solid state photomultiplier in the near infrared wavelength region. The demonstrated device performance far exceeds any available solid state photodetectors in the near infrared wavelength range. The measured devices have the following performance characteristics: gain > 2X105, excess noise factor < 1.05, rise time < 350ps, fall time < 500ps, dark current < 2X106 cps, operating voltage < 60V. These devices are ideal for researchers in the field of deep space optical communication, spectroscopy, industrial and scientific instrumentation, Ladar/Lidar, quantum cryptography, night vision and other military, defence and aerospace applications.

  8. Diffusion tensor imaging using a high-temperature superconducting resonator in a 3 T magnetic resonance imaging for a spontaneous rat brain tumor

    NASA Astrophysics Data System (ADS)

    Lin, In-Tsang; Yang, Hong-Chang; Chen, Jyh-Horng

    2013-02-01

    This study investigates the peri-tumor signal abnormalities of a spontaneous brain tumor in a rat by using a 4 cm high-temperature superconducting (HTS) surface resonator. Fractional anisotropy (FA) values derived from diffusion tensor imaging reflect the interstitial characteristic of the peri-lesional tissues of brain tumors. Low FA indicates interstitial tumor infiltration and tissue injury, while high FA indicates better tissue integrity. Better delineation of tissue contents obtained by the HTS surface resonator at 77 K may facilitate therapeutic strategy and improve clinical outcomes.

  9. Technology developments and first measurements on inverse Low Gain Avalanche Detector (iLGAD) for high energy physics applications

    NASA Astrophysics Data System (ADS)

    Carulla, M.; Fernández-García, M.; Fernández-Martínez, P.; Flores, D.; González, J.; Hidalgo, S.; Jaramillo, R.; Merlos, A.; Palomo, F. R.; Pellegrini, G.; Quirion, D.; Vila, I.

    2016-12-01

    The first Inverse Low Gain Avalanche Detector (iLGAD) have been fabricated at IMB-CNM (CSIC). The iLGAD structure includes the multiplication diffusions at the ohmic contact side while the segmentation is implemented at the front side with multiple p+ diffusions. Therefore, iLGAD is p on p position-sensitive detector with a uniform electric field all along the device area that guarantees the same signal amplification wherever a particle passes through the sensitive bulk solving the main draw of the LGAD microstrip detector. However, the detection current is dominated by holes flowing back from the multiplication junction with the subsequent increase of the transient current pulse duration in comparison with conventional LGAD counterparts. Applications of iLGAD range from tracking and timing applications, like determination of primary interaction vertex, to medical imaging. The paper addresses the optimization of the iLGAD structure with the aid of TCAD simulations, focusing on the electric field profiles of iLGAD and LGAD microstrip structures and the corresponding gain. The electrical performance of the first fabricated samples is also provided. For the first time, we have the experimental demonstration of the signal amplification of these novel iLGAD detectors.

  10. Spontaneous Transomental Hernia

    PubMed Central

    Lee, Seung Hun

    2016-01-01

    A transomental hernia through the greater or lesser omentum is rare, accounting for approximately 4% of internal hernias. Transomental hernias are generally reported in patients aged over fifty. In such instances, acquired transomental hernias are usual, are commonly iatrogenic, and result from surgical interventions or from trauma or peritoneal inflammation. In rare cases, such as the one described in this study, internal hernias through the greater or lesser omentum occur spontaneously as the result of senile atrophy without history of surgery, trauma, or inflammation. A transomental hernia has a high postoperative mortality rate of 30%, and emergency diagnosis and treatment are critical. We report a case of a spontaneous transomental hernia of the small intestine causing intestinal obstruction. An internal hernia with strangulation of the small bowel in the lesser sac was suspected from the image study. After an emergency laparotomy, a transomental hernia was diagnosed. PMID:26962535

  11. Spontaneous Iliopsoas Tendon Tear

    PubMed Central

    Rodriguez, Mary; Patnaik, Soumya; Wang, Peter

    2016-01-01

    Hip pain is one of the most common reasons for the elderly to present to the emergency department, and the differential diagnosis spectrum is vast. Iliopsoas injury is a relatively uncommon condition that may present with hip or groin pain. It is usually seen in athletes due to trauma, particularly flexion injuries. However, spontaneous iliopsoas tendon tear is extremely rare, and only a small number of cases have been reported; it has an estimated prevalence of 0.66% in individuals from 7 to 95 years. Risk factors include aging, use of steroids, and chronic diseases. Magnetic resonance imaging (MRI) using its high soft-tissue contrast resolution remains the most valuable imaging modality. A prompt diagnosis and treatment, which is usually conservative, is important to improve the quality of life in this group of patients. We describe a case of spontaneous iliopsoas tendon tear in an elderly woman. PMID:26929854

  12. High-power 1.25 µm InAs QD VECSEL based on resonant periodic gain structure

    NASA Astrophysics Data System (ADS)

    Albrecht, Alexander R.; Rotter, Thomas J.; Hains, Christopher P.; Stintz, Andreas; Xin, Guofeng; Wang, Tsuei-Lian; Kaneda, Yushi; Moloney, Jerome V.; Malloy, Kevin J.; Balakrishnan, Ganesh

    2011-03-01

    We compare an InAs quantum dot (QD) vertical external-cavity surface-emitting laser (VECSEL) design consisting of 4 groups of 3 closely spaced QD layers with a resonant periodic gain (RPG) structure, where each of the 12 QD layers is placed at a separate field antinode. This increased the spacing between the QDs, reducing strain and greatly improving device performance. For thermal management, the GaAs substrate was thinned and indium bonded to CVD diamond. A fiber-coupled 808 nm diode laser was used as pump source, a 1% transmission output coupler completed the cavity. CW output powers over 4.5 W at 1250 nm were achieved.

  13. Pharmacological characterization of ionic currents that regulate high-frequency spontaneous activity of electromotor neurons in the weakly electric fish, Apteronotus leptorhynchus.

    PubMed

    Smith, G Troy

    2006-01-01

    The neural circuit that controls the electric organ discharge (EOD) of the brown ghost knifefish (Apteronotus leptorhynchus) contains two spontaneous oscillators. Both pacemaker neurons in the medulla and electromotor neurons (EMNs) in the spinal cord fire spontaneously at frequencies of 500-1,000 Hz to control the EOD. These neurons continue to fire in vitro at frequencies that are highly correlated with in vivo EOD frequency. Previous studies used channel blocking drugs to pharmacologically characterize ionic currents that control high-frequency firing in pacemaker neurons. The goal of the present study was to use similar techniques to investigate ionic currents in EMNs, the other type of spontaneously active neuron in the electromotor circuit. As in pacemaker neurons, high-frequency firing of EMNs was regulated primarily by tetrodotoxin-sensitive sodium currents and by potassium currents that were sensitive to 4-aminopyridine and kappaA-conotoxin SIVA, but resistant to tetraethylammonium. EMNs, however, differed from pacemaker neurons in their sensitivity to some channel blocking drugs. Alpha-dendrotoxin, which blocks a subset of Kv1 potassium channels, increased firing rates in EMNs, but not pacemaker neurons; and the sodium channel blocker muO-conotoxin MrVIA, which reduced firing rates of pacemaker neurons, had no effect on EMNs. These results suggest that similar, but not identical, ionic currents regulate high-frequency firing in EMNs and pacemaker neurons. The differences in the ionic currents expressed in pacemaker neurons and EMNs might be related to differences in the morphology, connectivity, or function of these two cell types.

  14. Experimental Setup and Commissioning of a Test Facility for Gain Evaluation of Microchannel-Plate Photomultipliers in High Magnetic Field at Jefferson Lab

    NASA Astrophysics Data System (ADS)

    Bringley, Eric; Cao, Tongtong; Ilieva, Yordonka; Nadel-Turonski, Pawel; Park, Kijun; Zorn, Carl

    2014-09-01

    At the Thomas Jefferson National Accelerator Facility (JLab) a research and development project for a Detector of Internally-Reflected Cherenkov light for the upcoming Electron Ion Collider is underway. One goal is the development of a compact readout camera that can operate in high magnetic fields. Small-size photon sensors, such as Microchannel-Plate Photomultipliers (MCP-PMT), are key components of the readout. Here we present our work to set up and commission a dedicated test facility at JLab where MCP-PMT gain is evaluated in magnetic fields of up to 5 T, and to develop a test procedure and analysis software to determine the gain. We operate the setup in a single-photon mode, where a light-emitting diode delivers photons to the sensor's photocathode. The PMT spectrum is measured with a flash Analog-to-Digital converter (fADC). We model the spectrum as a sum of an exponential background and a convolution of Poisson and Gaussian distributions of the pedestal and multiple photoelectron peaks, respectively. We determine the PMT's gain from the position of the single-photoelectron peak obtained by fitting the fADC spectrum to the model. Our gain uncertainty is <10%. The facility is now established and will have a long-lasting value for sensor tests and beyond-nuclear-physics applications.

  15. Heat resistance and salt hypersensitivity in Lactococcus lactis due to spontaneous mutation of llmg_1816 (gdpP) induced by high-temperature growth.

    PubMed

    Smith, William M; Pham, Thi Huong; Lei, Lin; Dou, Junchao; Soomro, Aijaz H; Beatson, Scott A; Dykes, Gary A; Turner, Mark S

    2012-11-01

    During construction of several gene deletion mutants in Lactococcus lactis MG1363 which involved a high-temperature (37.5°C) incubation step, additional spontaneous mutations were observed which resulted in stable heat resistance and in some cases salt-hypersensitive phenotypes. Whole-genome sequencing of one strain which was both heat resistant and salt hypersensitive, followed by PCR and sequencing of four other mutants which shared these phenotypes, revealed independent mutations in llmg_1816 in all cases. This gene encodes a membrane-bound stress signaling protein of the GdpP family, members of which exhibit cyclic dimeric AMP (c-di-AMP)-specific phosphodiesterase activity. Mutations were predicted to lead to single amino acid substitutions or protein truncations. An independent llmg_1816 mutant (Δ1816), created using a suicide vector, also displayed heat resistance and salt hypersensitivity phenotypes which could be restored to wild-type levels following plasmid excision. L. lactis Δ1816 also displayed improved growth in response to sublethal concentrations of penicillin G. High-temperature incubation of a wild-type industrial L. lactis strain also resulted in spontaneous mutation of llmg_1816 and heat-resistant and salt-hypersensitive phenotypes, suggesting that this is not a strain-specific phenomenon and that it is independent of a plasmid integration event. Acidification of milk by the llmg_1816-altered strain was inhibited by lower salt concentrations than the parent strain. This study demonstrates that spontaneous mutations can occur during high-temperature growth of L. lactis and that inactivation of llmg_1816 leads to temperature resistance and salt hypersensitivity.

  16. Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice.

    PubMed

    Park, Soyoung; Lim, Yeseo; Shin, Sunhye; Han, Sung Nim

    2013-10-01

    Korean pine nut oil (PNO) has been reported to have favorable effects on lipid metabolism and appetite control. We investigated whether PNO consumption could influence weight gain, and whether the PNO-induced effect would result in an improvement of immune function in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed control diets with 10% energy fat from either PNO or soybean oil (SBO), or HFDs with 45% energy fat from 10% PNO or SBO and 35% lard, 20% PNO or SBO and 25% lard, or 30% PNO or SBO and 15% lard for 12 weeks. The proliferative responses of splenocytes upon stimulation with concanavalin A (Con A) or lipopolysaccharide (LPS), Con A-stimulated production of interleukin (IL)-2 and interferon (IFN)-γ, and LPS-stimulated production of IL-6, IL-1β, and prostaglandin E2 (PGE2) by splenocytes were determined. Consumption of HFDs containing PNO resulted in significantly less weight gain (17% less, P < 0.001), and lower weight gain was mainly due to less white adipose tissue (18% less, P = 0.001). The reduction in weight gain did not result in the overall enhancement in splenocyte proliferation. Overall, PNO consumption resulted in a higher production of IL-1β (P = 0.04). Replacement of SBO with PNO had no effect on the production of IL-2, IFN-γ, IL-6, or PGE2 in mice fed with either the control diets or HFDs. In conclusion, consumption of PNO reduced weight gain in mice fed with HFD, but this effect did not result in the overall improvement in immune responses.

  17. Auto-digital gain balancing: a new detection scheme for high-speed chemical species tomography of minor constituents

    NASA Astrophysics Data System (ADS)

    Pal, Sandip; McCann, Hugh

    2011-11-01

    In many dynamic gas-phase reaction processes, there is great interest to measure the distribution of minor constituents, i.e. <10-3 by volume (1000 ppm). One such case is the after-treatment of automotive gasoline engine exhaust by catalytic conversion, where a characteristic challenge is to image the distribution of 10 ppm (average) of carbon monoxide (CO) at 1000 frames per second across a 50 mm diameter exhaust pipe; this particular problem has been pursued as a case study. In this paper, we present a novel electronic scheme that achieves the required measurement of around 10-3 absorption with 10-4 precision at kHz bandwidth. This was not previously achievable with any known technology. We call the new scheme Auto-Digital Gain Balancing. It is amenable to replication for many simultaneous measurement channels, and it permits simultaneous measurement of multiple species, in some circumstances. Experimental demonstrations are presented in the near-infrared. In single scans of a tunable diode laser, measurements of both CO and CO2 have been made with 20 dB signal-to-noise ratio at peak absorption. This work paves the way for chemical species tomography of minor constituents in many dynamic gas-phase systems.

  18. Contemporary Review on Spontaneous Coronary Artery Dissection.

    PubMed

    Saw, Jacqueline; Mancini, G B John; Humphries, Karin H

    2016-07-19

    Spontaneous coronary artery dissection (SCAD) is gaining recognition as an important cause of myocardial infarction, especially in young women. There has been a surge in the diagnosis of SCAD in recent years, presumably due to an increased use of coronary angiography, and the clinical availability and application of high-resolution intracoronary imaging. The improved recognition and diagnosis, together with increased publications and attention through social media, have considerably raised awareness of this condition, which was once believed to be very rare. Recent publications of moderate to large contemporary case series have helped elucidate the early natural history, presenting characteristics (clinical and angiographic), underlying etiology, management, and cardiovascular outcomes with this condition, thus providing observations and important clinical insights of value to clinicians managing this challenging and perplexing patient cohort. The aim of our review is to provide a comprehensive contemporary update of SCAD to aid health care professionals in managing these patients in both the acute and chronic settings.

  19. Gaining Insights from a Case Study of High School Student Performance in Dual-Credit College Chemistry Courses

    ERIC Educational Resources Information Center

    White, Jacob; Hopkins, Robert; Shockley, Denise

    2014-01-01

    This report describes student performance in a state-level initiative that provided first-year college coursework in chemistry to high school students. Upon successful completion of the coursework, students received both high school and college credit. In this initiative, high school teachers team taught college-level chemistry courses in…

  20. Adaptive fuzzy decentralized control for large-scale nonlinear systems with time-varying delays and unknown high-frequency gain sign.

    PubMed

    Tong, Shaocheng; Liu, Changliang; Li, Yongming; Zhang, Huaguang

    2011-04-01

    In this paper, an adaptive fuzzy decentralized robust output feedback control approach is proposed for a class of large-scale strict-feedback nonlinear systems without the measurements of the states. The nonlinear systems in this paper are assumed to possess unstructured uncertainties, time-varying delays, and unknown high-frequency gain sign. Fuzzy logic systems are used to approximate the unstructured uncertainties, K-filters are designed to estimate the unmeasured states, and a special Nussbaum gain function is introduced to solve the problem of unknown high-frequency gain sign. Combining the backstepping technique with adaptive fuzzy control theory, an adaptive fuzzy decentralized robust output feedback control scheme is developed. In order to obtain the stability of the closed-loop system, a new lemma is given and proved. Based on this lemma and Lyapunov-Krasovskii functions, it is proved that all the signals in the closed-loop system are uniformly ultimately bounded and that the tracking errors can converge to a small neighborhood of the origin. The effectiveness of the proposed approach is illustrated from simulation results.

  1. High power gain switched laser diodes using a novel compact picosecond switch based on a GaAs bipolar junction transistor structure for pumping

    NASA Astrophysics Data System (ADS)

    Vainshtein, Sergey; Kostamovaara, Juha

    2006-04-01

    A number of up-to-date applications, including advanced optical radars with high single-shot resolution, precise 3 D imaging, laser tomography, time imaging spectroscopy, etc., require low-cost, compact, reliable sources enabling the generation of high-power (1-100 W) single optical pulses in the picosecond range. The well-known technique of using the gain-switching operation mode of laser diodes to generate single picosecond pulses in the mW range fails to generate high-power single picosecond pulses because of a lack of high-current switches operating in the picosecond range. We report here on the achieving of optical pulses of 45W / 70ps, or alternatively 5W / 40ps, with gain-switched commercial quantum well (QW) laser diodes having emitting areas of 250 × 200 μm and 75 × 2 μm, respectively. This was made possible by the use of a novel high-current avalanche switch based on a GaAs bipolar junction transistor (BJT) structure with a switching time (<200ps) comparable to the lasing delay. (The extremely fast transient in this switch is caused by the generation and spread of a comb of powerfully avalanching Gunn domains of ultra-high amplitude in the transistor structure.) A simulation code developed earlier but modified and carefully verified here allowed detailed comparison of the experimental and simulated laser responses and the transient spectrum.

  2. Ultra-thin single-layer transparent geometrical phase gradient metasurface and its application to high-gain circularly-polarized lens antenna

    NASA Astrophysics Data System (ADS)

    Li, Tang-Jing; Liang, Jian-Gang; Li, Hai-Peng; Liu, Ya-Qiao

    2016-09-01

    A new method to design an ultra-thin high-gain circularly-polarized antenna system with high efficiency is proposed based on the geometrical phase gradient metasurface (GPGM). With an accuracy control of the transmission phase and also the high transmission amplitude, the GPGM is capable of manipulating an electromagnetic wave arbitrarily. A focusing transmission lens working at Ku band is well optimized with the F/D of 0.32. A good focusing effect is demonstrated clearly by theoretical calculation and electromagnetic simulation. For further application, an ultra-thin single-layer transmissive lens antenna based on the proposed focusing metasurface operating at 13 GHz is implemented and launched by an original patch antenna from the perspective of high integration, simple structure, and low cost. Numerical and experimental results coincide well, indicating the advantages of the antenna system, such as a high gain of 17.6 dB, the axis ratio better than 2 dB, a high aperture efficiency of 41%, and also a simple fabrication process based on the convenient print circuit board technology. The good performance of the proposed antenna indicates promising applications in portable communication systems. Project supported by the National Natural Science Foundation of China (Grant No. 61372034).

  3. Compact high power mid-infrared optical parametric oscillator pumped by a gain-switched fiber laser with "figure-of-h" pulse shape.

    PubMed

    Jiang, Peipei; Chen, Tao; Wu, Bo; Yang, Dingzhong; Hu, Chengzhi; Wu, Pinghui; Shen, Yonghang

    2015-02-09

    We demonstrate a compact high power mid-infrared (MIR) optical parametric oscillator (OPO) pumped by a gain-switched linearly polarized, pulsed fiber laser. The gain-switched fiber laser was constructed with a piece of Yb doped polarization maintaining (PM) fiber, a pair of fiber Bragg gratings written into the matched passive PM fiber and 6 pigtailed pump laser diodes working at 915 nm with 30 W output peak power each. By modulating the pulse width of the pump laser diode, simple pedestal-free pulse shape or pedestal-free trailing pulse shape ("figure-of-h" as we call it) could be achieved from the gain-switched fiber laser. The laser was employed as the pump of a two-channel, periodically poled magnesium oxide lithium niobate-based OPO system. High power MIR emission was generated with average output power of 5.15 W at 3.8 μm channel and 8.54 W at 3.3 μm channel under the highest pump power of 45 W. The corresponding pump-to-idler conversion efficiency was computed to be 11.7% and 19.1%, respectively. Experimental results verify a significant improvement to signal-to-idler conversion efficiency by using "figure-of-h" pulses over simple pedestal-free pulses. Compared to the master oscillator power amplifier (MOPA) fiber laser counterpart, the presented gain switched fiber laser is more attractive in OPO pumping due to its compactness and simplicity which are beneficial to construction of OPO systems for practical MIR applications.

  4. Postnatal weight gain induced by overfeeding pups and maternal high-fat diet during the lactation period modulates glucose metabolism and the production of pancreatic and gastrointestinal peptides.

    PubMed

    Du, Qinwen; Hosoda, Hiroshi; Umekawa, Takashi; Kinouchi, Toshi; Ito, Natsuki; Miyazato, Mikiya; Kangawa, Kenji; Ikeda, Tomoaki

    2015-08-01

    The impact of rapid weight gain on glucose metabolism during the early postnatal period remains unclear. We investigated the influence of rapid weight gain under different nutritional conditions on glucose metabolism, focusing on the production of pancreatic and gastric peptides. On postnatal day (PND) 2, C57BL/6N pups were divided into three groups: control (C) pups whose dams were fed a control diet (10%kcal fat) and nursed 10 pups each; maternal high-fat diet (HFD) pups whose dams were fed an HFD (45%kcal fat) and nursed 10 pups each; and overfeeding (OF) pups whose dams were fed the control diet and nursed 4 pups each. Data were collected on PND 7, 14 and 21. The body weight gains of the HFD and OF pups were 1.2 times higher than that of the C pups. On PND 14, the HFD pups had higher blood glucose levels, but there were no significant differences in serum insulin levels between the HFD and C pups. The OF pups had higher blood glucose and serum insulin levels than that of the C pups. Insulin resistance was found in the HFD and OF pups. On PND 14, the content of incretins in the jejunum was increased in the OF pups, and acyl ghrelin in the stomach was upregulated in the HFD and OF pups. These results suggest that neonatal weight gain induced by overfeeding pups and maternal high-fat diet during the early postnatal period modulates the insulin sensitivity and the production of pancreatic and gastrointestinal peptides.

  5. Evaluation of Methionine Content in a High-Fat and Choline-Deficient Diet on Body Weight Gain and the Development of Non-Alcoholic Steatohepatitis in Mice

    PubMed Central

    Chiba, Tsuyoshi; Suzuki, Sachina; Sato, Yoko; Itoh, Tatsuki; Umegaki, Keizo

    2016-01-01

    Aim Non-alcoholic steatohepatitis (NASH) is a globally recognized liver disease. A methionine- and choline-deficient diet is used to induce NASH in mice; however, this diet also causes severe body weight loss. To resolve this issue, we examined the effects of methionine content in a high-fat and choline-deficient (HFCD) diet on body weight and the development of NASH in mice. Methods C57BL/6J mice (male, 10 weeks of age) were fed an L-amino acid rodent (control) diet, high-fat (HF) diet, or HFCD diet containing various amounts of methionine (0.1–0.6% (w/w)) for 12 weeks. Plasma lipid levels, hepatic lipid content and inflammatory marker gene expression were measured, and a pathological analysis was conducted to evaluate NASH. Results The 0.1% methionine in HFCD diet suppressed body weight gain, which was lower than that with control diet. On the other hand, the 0.2% methionine in HFCD diet yielded similar body weight gains as the control diet, while more than 0.4% methionine showed the same body weight gains as the HF diet. Liver weights and hepatic lipid contents were the greatest with 0.1% methionine and decreased in a methionine dose-dependent manner. Pathological analysis, NAFLD activity scores and gene expression levels in the liver revealed that 0.1% and 0.2% methionine for 12 weeks induced NASH, whereas 0.4% and 0.6% methionine attenuated the induction of NASH by HFCD diet. However, the 0.2% methionine in HFCD diet did not induce insulin resistance, despite the body weight gain. Conclusions The 0.2% methionine in HFCD diet for 12 weeks was able to induce NASH without weight loss. PMID:27723801

  6. Superiority of branched side chains in spontaneous nanowire formation: exemplified by poly(3-2-methylbutylthiophene) for high-performance solar cells.

    PubMed

    Chen, Hsieh-Chih; Wu, I-Che; Hung, Jui-Hsiang; Chen, Fu-Je; Chen, I-Wen P; Peng, Yung-Kang; Lin, Chao-Sung; Chen, Chun-Hsien; Sheng, Yu-Jane; Tsao, Heng-Kwong; Chou, Pi-Tai

    2011-04-18

    One-dimensional nanostructures containing heterojunctions by conjugated polymers, such as nanowires, are expected to greatly facilitate efficient charge transfer in bulk-heterojunction (BHJ) solar cells. Thus, a combined theoretical and experimental approach is pursued to explore spontaneous nanowire formation. A dissipative particle dynamics simulation is first performed to study the morphologies formed by rodlike polymers with various side-chain structures. The results surprisingly predict that conjugated polymers with branched side chains are well suited to form thermodynamically stable nanowires. Proof of this concept is provided via the design and synthesis of a branched polymer of regioregular poly(3-2-methylbutylthiophene) (P3MBT), which successfully demonstrates highly dense nanowire formation free from any stringent conditions and stratagies. In BHJ solar cells fabricated using a blend of P3MBT and [6,6]-phenyl-C71-butyric acid methyl ester (PC(71) BM), P3MBT polymers are self-organized into highly crystalline nanowires with a d(100) spacing of 13.30 Å. The hole mobility of the P3MBT:PC(71) BM (1:0.5 by weight) blend film reaches 3.83 × 10(-4) cm(2) V(-1) s(-1) , and the maximum incident photon-to-current efficiency reaches 68%. The results unambiguously prove the spontaneous formation of nanowires using solution-processable conjugated polymers with branched alkyl side chains in BHJ solar cells.

  7. Excitation dependent two-component spontaneous emission and ultrafast amplified spontaneous emission in dislocation-free InGaN nanowires

    NASA Astrophysics Data System (ADS)

    You, Guanjun; Guo, Wei; Zhang, Chunfeng; Bhattacharya, Pallab; Henderson, Ron; Xu, Jian

    2013-03-01

    Amplified spontaneous emission (ASE) at 456 nm from In0.2Ga0.8N nanowires grown on (001) silicon by catalyst-free molecular beam epitaxy was observed at room temperature under femtosecond excitation. The photoluminescence spectra below ASE threshold consist of two spontaneous emission bands centered at ˜555 nm and ˜480 nm, respectively, revealing the co-existence of deeply and shallowly localized exciton states in the nanowires. The ASE peak emerges from the 480 nm spontaneous emission band when the excitation density exceeds ˜120 μJ/cm2, indicating that optical gain arises from the radiative recombination of shallowly localized excitons in the nanowires. Time-resolved photoluminescence measurements revealed that the ASE process completes within 1.5 ps, suggesting a remarkably high stimulated emission recombination rate in one-dimensional InGaN nanowires.

  8. Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study

    PubMed Central

    Huang, Xin; Zhou, Fu-Qing; Hu, Yu-Xiang; Xu, Xiao-Xuan; Zhou, Xiong; Zhong, Yu-Lin; Wang, Jun; Wu, Xiao-Rong

    2016-01-01

    Objective Many previous reports have demonstrated significant neural anatomy changes in the brain of high myopic (HM) patients, whereas the spontaneous brain activity changes in the HM patients at rest are not well studied. Our objective was to use amplitude of low-frequency fluctuation (ALFF) method to investigate the changes in spontaneous brain activity in HM patients and their relationships with clinical features. Methods A total of 38 patients with HM (17 males and 21 females) and 38 healthy controls (HCs) (17 males and 21 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. The relationship between the mean ALFF signal values in many brain regions and the clinical features in HM patients was calculated by correlation analysis. Results Compared with HCs, the HM patients had significantly lower ALFF in the right inferior and middle temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus/putamen, right inferior frontal gyrus/putamen/insula, right middle frontal gyrus, and right inferior parietal lobule and higher ALFF values in the bilateral midcingulate cortex, left postcentral gyrus, and left precuneus/inferior parietal lobule. However, no relationship was found between the mean ALFF signal values of the different areas and the clinical manifestations in HM. Conclusion The HM patients were affected with brain dysfunction in many regions, which may indicate the presence of neurobiological changes involving deficits in language understanding and attentional control in HM patients. PMID:27881920

  9. High-gain 87 cm-1 Raman line of KYW and its impact on continuous-wave Raman laser operation.

    PubMed

    Sarang, Soumya; Williams, Robert J; Lux, Oliver; Kitzler, Ondrej; McKay, Aaron; Jasbeer, Hadiya; Mildren, Richard P

    2016-09-19

    We report a quasi-continuous-wave external cavity Raman laser based on potassium yttrium tungstate (KYW). Laser output efficiency and spectrum are severely affected by the presence of high gain Raman modes of low frequency (< 250 cm-1) that are characteristic of this crystal class. Output spectra contained frequency combs spaced by the low frequency modes but with the overall pump-to-Stokes conversion efficiency at least an order of magnitude lower than that typically obtained in other crystal Raman lasers. We elucidate the primary factors affecting laser performance by measuring the Raman gain coefficients of the low energy modes and numerically modeling the cascading dynamics. For a pump polarization aligned to the Ng crystallo-optic axis, the 87 cm-1 Raman mode has a gain coefficient of 9.2 cm/GW at 1064 nm and a dephasing time T2 = 9.6 ps, which are both notably higher than for the 765 cm-1 mode usually considered to be the prominent Raman mode of KYW. The implications for continuous-wave Raman laser design and the possible advantages for applications are discussed.

  10. High signal-to-noise ratio sensing with Shack-Hartmann wavefront sensor based on auto gain control of electron multiplying CCD

    NASA Astrophysics Data System (ADS)

    Zhu, Zhao-Yi; Li, Da-Yu; Hu, Li-Fa; Mu, Quan-Quan; Yang, Cheng-Liang; Cao, Zhao-Liang; Xuan, Li

    2016-09-01

    High signal-to-noise ratio can be achieved with the electron multiplying charge-coupled-device (EMCCD) applied in the Shack-Hartmann wavefront sensor (S-H WFS) in adaptive optics (AO). However, when the brightness of the target changes in a large scale, the fixed electron multiplying (EM) gain will not be suited to the sensing limitation. Therefore an auto-gain-control method based on the brightness of light-spots array in S-H WFS is proposed in this paper. The control value is the average of the maximum signals of every light spot in an array, which has been demonstrated to be kept stable even under the influence of some noise and turbulence, and sensitive enough to the change of target brightness. A goal value is needed in the control process and it is predetermined based on the characters of EMCCD. Simulations and experiments have demonstrated that this auto-gain-control method is valid and robust, the sensing SNR reaches the maximum for the corresponding signal level, and especially is greatly improved for those dim targets from 6 to 4 magnitude in the visual band. Project supported by the National Natural Science Foundation of China (Grant Nos. 11174274, 61205021, and 61405194) and the State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences.

  11. A gain-coefficient switched Alexandrite laser

    NASA Astrophysics Data System (ADS)

    Lee, Chris J.; van der Slot, Peter J. M.; Boller, Klaus-J.

    2013-01-01

    We report on a gain-coefficient switched Alexandrite laser. An electro-optic modulator is used to switch between high and low gain states by making use of the polarization dependent gain of Alexandrite. In gain-coefficient switched mode, the laser produces 85 ns pulses with a pulse energy of 240 mJ at a repetition rate of 5 Hz.

  12. How Much Professional Development Is Needed to Effect Positive Gains in K-6 Student Achievement on High Stakes Science Tests?

    ERIC Educational Resources Information Center

    Shymansky, James A.; Wang, Tzu-Ling; Annetta, Leonard A.; Yore, Larry D.; Everett, Susan A.

    2012-01-01

    This paper is a report of a study that examines the relationship between teacher participation in a multi-year, K-6 professional development effort and the "high stakes" science test scores of different student groups in 33 rural mid-west school districts in the USA. The professional development program involved 1,269 elementary school…

  13. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice.

    PubMed

    Tillman, Erik J; Morgan, Donald A; Rahmouni, Kamal; Swoap, Steven J

    2014-01-01

    High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Male C57Bl/6 mice were weaned to a randomly assigned diet: high fructose, high sucrose, high fat, or control (sugar-free, low-fat). Mice were maintained on their diets for at least 14 weeks. While fructose-fed mice regularly consumed more kcal and expended more energy, there was no difference in body weight compared to control by the end of the study. Additionally, after 14 weeks, both fructose-fed and control mice displayed similar leptin sensitivity. Fructose-feeding also did not change circulating glucose, triglycerides, or free fatty acids. Though fructose has been linked to obesity in several animal models, our data fail to support a role for fructose intake through food lasting 3 months in altering of body weight and leptin signaling in mice. The lack of impact of fructose in the food of growing mice on either body weight or leptin sensitivity over this time frame was surprising, and important information for researchers interested in fructose and body weight regulation.

  14. Gathering Feedback for Teaching: Combining High-Quality Observations with Student Surveys and Achievement Gains. Research Paper. MET Project

    ERIC Educational Resources Information Center

    Kane, Thomas J.; Staiger, Douglas O.

    2012-01-01

    There is a growing consensus that teacher evaluation in the United States is fundamentally broken. Few would argue that a system that tells 98 percent of teachers they are "satisfactory" benefits anyone--including teachers. The nation's collective failure to invest in high-quality professional feedback to teachers is inconsistent with…

  15. IR gain monitor

    NASA Astrophysics Data System (ADS)

    Hilbert, Bryan

    2013-10-01

    The gain of the IR channel of WFC3 will be measured using a series of internal flat fields. Using knowledge gained from ground testing and previous cycles, we propose to collect flat field ramps which will be used to create photon transfer curves and give a measure of the gain. This continues the strategy of last cycle's gain monitor, in proposal 13080.

  16. Insights into composition/structure/function relationships of Doxil® gained from "high-sensitivity" differential scanning calorimetry.

    PubMed

    Wei, Xiaohui; Cohen, Rivka; Barenholz, Yechezkel

    2016-07-01

    Thermotropic behavior of Doxil® and its generic, Lipodox®, was characterized using "high-sensitivity" differential scanning calorimetry (DSC). This is the first report that two distinct endotherms were observed in Doxil and Lipodox upon heating. The first (Tm at 51±2°C) is broad and of low enthalpy, representing the membrane lipid phase transition, which occurs despite having high (38mole%) cholesterol. The second (Tm at ∼70°C) is narrow, representing melting of the intraliposomal doxorubicin-sulfate nanocrystals. The thermograms of Doxil and Lipodox are practically identical. The membrane phase transition is similar to that of drug-free nanoliposomes of the same size and lipid composition as Doxil, suggesting lack of significant drug-membrane interaction. The melting endotherm of the intraliposomal nanocrystals is 2.0-2.5-fold narrower than that of the crystals formed in a solution of 250mM ammonium sulfate and >60mg/ml doxorubicin. This suggests that nanovolume of liposomes improves doxorubicin-sulfate crystallinity. Moreover, both phase transitions are reversible in cycled DSC scanning (15-90-15°C). This indicates an unexpected "non-leaky" phospholipid phase transition and excellent physical and chemical stabilities of Doxil after short exposure to high temperature. Reducing mole% of cholesterol results in a "leaky" membrane phase transition of higher enthalpy. Namely, high mole% cholesterol is essential for the resistance to drug leakage during phase transition. Pegylated liposomal doxorubicin in which HSPC was replaced by DPPC shows the same non-leaky phase transition but at a lower temperature, indicating this type of phase transition is not unique to Doxil. The presence of DSPE-PEG2k increases the cooperativity of the phase transition. High-sensitivity DSC helps illuminate composition/structure/function relationships of Doxil, and is useful for the equivalence/similarity studies.

  17. Spontaneous Action and Transformative Learning: Empirical Investigations and Pragmatist Reflections

    ERIC Educational Resources Information Center

    Nohl, Arnd-Michael

    2009-01-01

    Whereas present theories of transformative learning tend to focus on the rational and reflective actor, in this article it is suggested that spontaneous action may play a decisive role in transformative learning too. In the spontaneity of action, novelty finds its way into life, gains momentum, is respected by others and reflected by the actor.…

  18. Novel high-gain, improved-bandwidth, finned-ladder V-band Traveling-Wave Tube slow-wave circuit design

    NASA Technical Reports Server (NTRS)

    Kory, Carol L.; Wilson, Jeffrey D.

    1994-01-01

    The V-band frequency range of 59-64 GHz is a region of the millimeter-wave spectrum that has been designated for inter-satellite communications. As a first effort to develop a high-efficiency V-band Traveling-Wave Tube (TWT), variations on a ring-plane slow-wave circuit were computationally investigated to develop an alternative to the more conventional ferruled coupled-cavity circuit. The ring-plane circuit was chosen because of its high interaction impedance, large beam aperture, and excellent thermal dissipation properties. Despite these advantages, however, low bandwidth and high voltage requirements have, until now, prevented its acceptance outside the laboratory. In this paper, the three-dimensional electrodynamic simulation code MAFIA (solution of MAxwell's Equation by the Finite-Integration-Algorithm) is used to investigate methods of increasing the bandwidth and lowering the operating voltage of the ring-plane circuit. Calculations of frequency-phase dispersion, beam on-axis interaction impedance, attenuation and small-signal gain per wavelength were performed for various geometric variations and loading distributions of the ring-plane TWT slow-wave circuit. Based on the results of the variations, a circuit termed the finned-ladder TWT slow-wave circuit was designed and is compared here to the scaled prototype ring-plane and a conventional ferruled coupled-cavity TWT circuit over the V-band frequency range. The simulation results indicate that this circuit has a much higher gain, significantly wider bandwidth, and a much lower voltage requirement than the scaled ring-plane prototype circuit, while retaining its excellent thermal dissipation properties. The finned-ladder circuit has a much larger small-signal gain per wavelength than the ferruled coupled-cavity circuit, but with a moderate sacrifice in bandwidth.

  19. Purcell enhancement of fast-dephasing spontaneous emission from electron-hole droplets in high-Q silicon photonic crystal nanocavities

    NASA Astrophysics Data System (ADS)

    Sumikura, Hisashi; Kuramochi, Eiichi; Taniyama, Hideaki; Notomi, Masaya

    2016-11-01

    We have observed electron-hole droplet emission enhanced by silicon photonic crystal nanocavities with different Q values and simulated their Purcell effect using a semiclassical theory considering the temporal dephasing of the emission. When the photon loss rate of the nanocavities is smaller than the dephasing rate of the emission, the cavity-enhanced integrated photoluminescence (PL) intensity is unchanged by the cavity Q value. This is because the Purcell enhancement of the spontaneous emission rate is saturated in a high-Q region. In contrast, the peak intensity of the cavity-enhanced PL is proportional to the cavity Q value without saturation. These results suggest that a high-Q nanocavity is suitable for fabricating bright narrowband light emitting devices that concentrate the broadband emission energy of fast-dephasing emitters in a narrowband cavity resonance.

  20. High-Resolution Three-Dimensional Structural Data Quantify the Impact of Photoinhibition on Long-Term Carbon Gain in Wheat Canopies in the Field1[OPEN

    PubMed Central

    Burgess, Alexandra J.; Retkute, Renata; Pound, Michael P.; Foulkes, John; Preston, Simon P.; Jensen, Oliver E.; Pridmore, Tony P.; Murchie, Erik H.

    2015-01-01

    Photoinhibition reduces photosynthetic productivity; however, it is difficult to quantify accurately in complex canopies partly because of a lack of high-resolution structural data on plant canopy architecture, which determines complex fluctuations of light in space and time. Here, we evaluate the effects of photoinhibition on long-term carbon gain (over 1 d) in three different wheat (Triticum aestivum) lines, which are architecturally diverse. We use a unique method for accurate digital three-dimensional reconstruction of canopies growing in the field. The reconstruction method captures unique architectural differences between lines, such as leaf angle, curvature, and leaf density, thus providing a sensitive method of evaluating the productivity of actual canopy structures that previously were difficult or impossible to obtain. We show that complex data on light distribution can be automatically obtained without conventional manual measurements. We use a mathematical model of photosynthesis parameterized by field data consisting of chlorophyll fluorescence, light response curves of carbon dioxide assimilation, and manual confirmation of canopy architecture and light attenuation. Model simulations show that photoinhibition alone can result in substantial reduction in carbon gain, but this is highly dependent on exact canopy architecture and the diurnal dynamics of photoinhibition. The use of such highly realistic canopy reconstructions also allows us to conclude that even a moderate change in leaf angle in upper layers of the wheat canopy led to a large increase in the number of leaves in a severely light-limited state. PMID:26282240

  1. Porcine adiponectin receptor 1 transgene resists high-fat/sucrose diet-induced weight gain, hepatosteatosis and insulin resistance in mice.

    PubMed

    Liu, Bing-Hsien; Lin, Yuan-Yu; Wang, Ya-Chin; Huang, Chao-Wei; Chen, Chih-Chien; Wu, Shinn-Chih; Mersmann, Harry J; Cheng, Winston T K; Ding, Shih-Torng

    2013-01-01

    Adiponectin and its receptors have been demonstrated to play important roles in regulating glucose and lipid metabolism in mice. Obesity, type II diabetes and cardiovascular disease are highly correlated with down-regulated adiponectin signaling. In this study, we generated mice overexpressing the porcine Adipor1 transgene (pAdipor1) to study its beneficial effects in metabolic syndromes as expressed in diet-induced obesity, hepatosteatosis and insulin resistance. Wild-type (WT) and pAdipor1 transgenic mice were fed ad libitum with a standard chow diet (Chow) or a high-fat/sucrose diet (HFSD) for 24 weeks, beginning at 6 to 7 weeks of age. There were 12 mice per genetic/diet/sex group. When challenged with HFSD to induce obesity, the pAdipor1 transgenic mice resisted development of weight gain, hepatosteatosis and insulin resistance. These mice had lowered plasma adiponectin, triglyceride and glycerol concentrations compared to WT mice. Moreover, we found that (indicated by mRNA levels) fatty acid oxidation was enhanced in skeletal muscle and adipose tissue, and liver lipogenesis was inhibited. The pAdipor1 transgene also restored HFSD-reduced phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose transporter 4 mRNA in the adipose tissues, implying that the increased Pck1 may promote glyceroneogenesis to reduce glucose intolerance and thus activate the flux of glyceride-glycerol to resist diet-induced weight gain in the adipose tissues. Taken together, we demonstrated that pAdipor1 can prevent diet-induced weight gain and insulin resistance. Our findings may provide potential therapeutic strategies for treating metabolic syndromes and obesity, such as treatment with an ADIPOR1 agonist or activation of Adipor1 downstream targets.

  2. Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer

    PubMed Central

    Bermudo, Raquel; Abia, David; Ferrer, Berta; Nayach, Iracema; Benguria, Alberto; Zaballos, Ángel; del Rey, Javier; Miró, Rosa; Campo, Elías; Martínez-A, Carlos; Ortiz, Ángel R; Fernández, Pedro L; Thomson, Timothy M

    2008-01-01

    Background Transcriptional profiling of prostate cancer (PC) has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal abnormalities associated with PC. The combination of both classes of data for the same sample cohort might provide better criteria for identifying relevant factors involved in neoplasia. Here we describe transcriptional signatures identifying distinct normal and tumoral prostate tissue compartments, and the inference and demonstration of a new, highly recurrent copy number gain on chromosome 17q25.3. Methods We have applied transcriptional profiling to tumoral and non-tumoral prostate samples with relatively homogeneous epithelial representations as well as pure stromal tissue from peripheral prostate and cultured cell lines, followed by quantitative RT-PCR validations and immunohistochemical analysis. In addition, we have performed in silico colocalization analysis of co-regulated genes and validation by fluorescent in situ hybridization (FISH). Results The transcriptomic analysis has allowed us to identify signatures corresponding to non-tumoral luminal and tumoral epithelium, basal epithelial cells, and prostate stromal tissue. In addition, in silico analysis of co-regulated expression of physically linked genes has allowed us to predict the occurrence of a copy number gain at chromosomal region 17q25.3. This computational inference was validated by fluorescent in situ hybridization, which showed gains in this region in over 65% of primary and metastatic tumoral samples. Conclusion Our approach permits to directly link gene copy number variations with transcript co-regulation in association with neoplastic states. Therefore, transcriptomic studies of carefully selected samples can unveil new diagnostic markers and transcriptional signatures highly specific of PC, and lead to the discovery of novel genomic abnormalities that may provide additional

  3. High Magnetic Shear Gain in a Liquid Sodium Stable Couette Flow Experiment: A Prelude to an {alpha}-{Omega} Dynamo

    SciTech Connect

    Colgate, Stirling A.; Beckley, Howard; Si, Jiahe; Martinic, Joe; Westpfahl, David; Slutz, James; Westrom, Cebastian; Klein, Brianna; Schendel, Paul; Scharle, Cletus; McKinney, Travis; Ginanni, Rocky; Bentley, Ian; Mickey, Timothy; Ferrel, Regnar; Li, Hui; Pariev, Vladimir; Finn, John

    2011-04-29

    The {Omega} phase of the liquid sodium {alpha}-{Omega} dynamo experiment at New Mexico Institute of Mining and Technology in cooperation with Los Alamos National Laboratory has demonstrated a high toroidal field B{sub {phi}} that is {approx_equal}8xB{sub r}, where B{sub r} is the radial component of an applied poloidal magnetic field. This enhanced toroidal field is produced by the rotational shear in stable Couette flow within liquid sodium at a magnetic Reynolds number Rm{approx_equal}120. Small turbulence in stable Taylor-Couette flow is caused by Ekman flow at the end walls, which causes an estimated turbulence energy fraction of ({delta}v/v){sup 2{approx}}10{sup -3}.

  4. Species' habitat use inferred from environmental variables at multiple scales: How much we gain from high-resolution vegetation data?

    NASA Astrophysics Data System (ADS)

    Gastón, Aitor; Ciudad, Carlos; Mateo-Sánchez, María C.; García-Viñas, Juan I.; López-Leiva, César; Fernández-Landa, Alfredo; Marchamalo, Miguel; Cuevas, Jorge; de la Fuente, Begoña; Fortin, Marie-Josée; Saura, Santiago

    2017-03-01

    Spatial resolution of environmental data may influence the results of habitat selection models. As high-resolution data are usually expensive, an assessment of their contribution to the reliability of habitat models is of interest for both researchers and managers. We evaluated how vegetation cover datasets of different spatial resolutions influence the inferences and predictive power of multi-scale habitat selection models for the endangered brown bear populations in the Cantabrian Range (NW Spain). We quantified the relative performance of three types of datasets: (i) coarse resolution data from Corine Land Cover (minimum mapping unit of 25 ha), (ii) medium resolution data from the Forest Map of Spain (minimum mapping unit of 2.25 ha and information on forest canopy cover and tree species present in each polygon), and (iii) high-resolution Lidar data (about 0.5 points/m2) providing a much finer information on forest canopy cover and height. Despite all the models performed well (AUC > 0.80), the predictive ability of multi-scale models significantly increased with spatial resolution, particularly when other predictors of habitat suitability (e.g. human pressure) were not used to indirectly filter out areas with a more degraded vegetation cover. The addition of fine grain information on forest structure (LiDAR) led to a better understanding of landscape use and a more accurate spatial representation of habitat suitability, even for a species with large spatial requirements as the brown bear, which will result in the development of more effective measures to assist endangered species conservation.

  5. New insights into hydrochemical processes in lowland river systems gained from in situ, high-resolution monitoring

    NASA Astrophysics Data System (ADS)

    Wade, Andrew; Palmer-Felgate, Elizabeth; Halliday, Sarah; Skeffington, Richard; Loewenthal, Matthew; Jarvie, Helen; Bowes, Michael; Greenway, Gillian; Haswell, Stephen; Bell, Ian; Joly, Etienne; Fallatah, Ahmed; Neal, Colin; Williams, Richard; Gozzard, Emma; Newman, Jonathan

    2013-04-01

    This work focuses on the insights obtained from in situ, high-resolution hydrochemical monitoring in three lowland UK catchments experiencing different levels of nutrient enrichment. Between November 2009 and February 2012, the upper River Kennet, the River Enborne and The Cut, all located within the Thames basin, southeast England, were instrumented with in situ analytical equipment to make hourly measurements of a range of hydrochemical determinands. The upper River Kennet is a rural catchment with limited effluent inputs above the selected monitoring point. The River Enborne is a rural catchment, impacted by agricultural runoff, and septic tank and sewage treatment works (STWs) discharges. The Cut is a highly urbanised system significantly affected by STW discharges. On the upper River Kennet and the River Enborne hourly measurements of Total Reactive Phosphorus (TRP) were made using a Systea Micromac C. In addition on the River Enborne, a Hach Lange Nitratax was used to measure nitrate (NO3). On The Cut both Total P and TRP were measured using a Hach Lange Phosphax Sigma. At all stations nutrient monitoring was supplemented with hourly pH, chlorophyll, dissolved oxygen, conductivity, turbidity and water temperature using YSI 6600 Multi-parameter sondes. Instream hydrochemical dynamics were investigated using non-stationary time-series analysis techniques. The results reveal complex nutrient dynamics, with diurnal patterns which exhibit seasonal changes in phase and amplitude, and are influenced by flow conditions, shading and nutrient sources. On the River Enborne a marked diurnal cycle was present within the streamwater NO3 time-series. The cycle was strongest in the spring before riparian shading developed. At times of low flow a two peak diurnal cycle was also evident in the streamwater NO3 time-series. The reduction in diurnal NO3 processing after the development of riparian shading was also accompanied by a marked drop in dissolved oxygen at this time. The

  6. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice

    PubMed Central

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-01-01

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice. PMID:27658722

  7. Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice.

    PubMed

    Heo, Jaeyoung; Seo, Minseok; Park, Hwanhee; Lee, Woon Kyu; Guan, Le Luo; Yoon, Joon; Caetano-Anolles, Kelsey; Ahn, Hyeonju; Kim, Se-Young; Kang, Yoon-Mo; Cho, Seoae; Kim, Heebal

    2016-09-23

    Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice.

  8. Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.

    PubMed

    White, Pollyanna A S; Araújo, Jessica M D; Cercato, Luana M; Souza, Lucas A; Barbosa, Ana Paula Oliveira; Quintans-Junior, Lucindo José; Machado, Ubiratan F; Camargo, Enilton A; Brito, Luciana C; Santos, Marcio Roberto V

    2016-02-01

    Chrysobalanus icaco L. is a medicinal plant present in the Brazilian coastline and known for its hypoglicemic and antioxidant properties. Here, we assessed the beneficial metabolic effects of the aqueous extract of C. icaco (AECI) leaves in diet-induced obese mice. Swiss mice were fed standard chow (SC used as controls) or high-fat diet (HFD) to induce obesity. After 10 weeks, mice on each diet were divided into two groups with one group used as control while the other group treated with AECI for 4 weeks resulting in four groups of mice: SC; SC treated with AECI (SC + AECI); HFD; and HFD treated with AECI (HFD + AECI). AECI was administered drinking water at about 200 mg/kg. AECI was able to normalize insulin (13,682 ± 1090 vs. 9828 ± 485 AU, P < .05) and fasting blood glucose (192.8 ± 14.2 vs. 132.3 ± 6.4 mg/dL, P < .05) and inhibit weight gain (39 ± 5.7%) and fat storage in liver (72.60 ± 3.83%, P < .0001), despite the high-fat intake. These findings reinforce the use of AECI in hyperglycemia and highlight the potential extract's effect in preventing weight gain and fat accumulation in liver of diet-induced obese mice.

  9. Evaluation of implant strategies in Angus-sired steers with high or low genetic potential for marbling and gain.

    PubMed

    Black, D N; Neville, B W; Crosswhite, M R; Dahlen, C R

    2015-11-01

    Sixty-nine Angus-sired steer calves (332.3 kg initial BW) were used to determine the effects of single or double implant strategies on steers of high or low genetic potential (GP) determined by the GeneMax (Zoetis, Florham Park, NJ) genetic profiling test. Steers were assigned to treatments in a 2 × 2 factorial design with factors of 1) composite GP score (high, mean GP score of 86.5 [HI]; low, mean GP score of 25.3[LO]) and 2) implant strategy (single, steers implanted on d 70 [1X], or double, steers implanted d 0 and 70 [2X]). All steers were given the same implant (Revalor-S; Merck Animal Health, Summit, NJ), with the 2X group implanted on d 0 and 70 and the 1X group implanted only on d 70. A diet containing 1.38 Mcal NEg/kg DM was fed ad libitum, once daily. Ultrasound was used to measure body composition characteristics on d 0 and 70. Steers were harvested after 140 d on feed. At both the d-0 and d-70 ultrasound, HI steers had greater ( < 0.001) percent intramuscular fat (IMF) than LO steers, but no differences ( ≥ 0.24) were observed in LM area (LMA), rib fat thickness (RF), or rump fat thickness (RMFT). Steers in the 2X group had larger ( = 0.02) LMA and less ( = 0.03) IMF on d 70 than 1X steers and no differences ( ≥ 0.50) in RF or RMFT were observed. From d 0 to 70, HI steers had ADG, DMI, and G:F ( ≥ 0.60) similar to LO steers; however, 2X steers had greater ( < 0.001) ADG and were more ( < 0.001) feed efficient compared with 1X steers during the same interval. Over the entire 140-d feeding period, there were no differences ( ≥ 0.6) in BW, ADG, DMI, or G:F between GP groups; however, 2X steers had greater ( = 0.03) ADG compared with 1X steers and still had similar ( ≥ 0.12) DMI and G:F. Upon slaughter, marbling score tended to be impacted by a GP × implant interaction (499.9 ± 18.5, 545.6 ± 18.5, 487.1 ± 18.5, and 469.8 ± 18.5 for HI and 2X, HI and 1X, LO and 2X, and LO and 1X, respectively; = 0.06). No differences ( ≥ 0.7) were observed

  10. A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High-Fat–Fed Mice

    PubMed Central

    Fink, Brian D.; Herlein, Judith A.; Guo, Deng Fu; Kulkarni, Chaitanya; Weidemann, Benjamin J.; Yu, Liping; Grobe, Justin L.; Rahmouni, Kamal; Kerns, Robert J.

    2014-01-01

    We hypothesized that the mitochondrial-targeted antioxidant, mitoquinone (mitoQ), known to have mitochondrial uncoupling properties, might prevent the development of obesity and mitigate liver dysfunction by increasing energy expenditure, as opposed to reducing energy intake. We administered mitoQ or vehicle (ethanol) to obesity-prone C57BL/6 mice fed high-fat (HF) or normal-fat (NF) diets. MitoQ (500 µM) or vehicle (ethanol) was added to the drinking water for 28 weeks. MitoQ significantly reduced total body mass and fat mass in the HF-fed mice but had no effect on these parameters in NF mice. Food intake was reduced by mitoQ in the HF-fed but not in the NF-fed mice. Average daily water intake was reduced by mitoQ in both the NF- and HF-fed mice. Hypothalamic expression of neuropeptide Y, agouti-related peptide, and the long form of the leptin receptor were reduced in the HF but not in the NF mice. Hepatic total fat and triglyceride content did not differ between the mitoQ-treated and control HF-fed mice. However, mitoQ markedly reduced hepatic lipid hydroperoxides and reduced circulating alanine aminotransferase, a marker of liver function. MitoQ did not alter whole-body oxygen consumption or liver mitochondrial oxygen utilization, membrane potential, ATP production, or production of reactive oxygen species. In summary, mitoQ added to drinking water mitigated the development of obesity. Contrary to our hypothesis, the mechanism involved decreased energy intake likely mediated at the hypothalamic level. MitoQ also ameliorated HF-induced liver dysfunction by virtue of its antioxidant properties without altering liver fat or mitochondrial bioenergetics. PMID:25301169

  11. New insights into nitrate dynamics in a karst groundwater system gained from in situ high-frequency optical sensor measurements

    NASA Astrophysics Data System (ADS)

    Opsahl, S. P.; Musgrove, M.; Slattery, R. N.

    2017-03-01

    Understanding nitrate dynamics in groundwater systems as a function of climatic conditions, especially during contrasting patterns of drought and wet cycles, is limited by a lack of temporal and spatial data. Nitrate sensors have the capability for making accurate, high-frequency measurements of nitrate in situ, but have not yet been evaluated for long-term use in groundwater wells. We measured in situ nitrate continuously in two groundwater monitoring wells -one rural and one urban-located in the recharge zone of a productive karst aquifer in central Texas in order to resolve changes that occur over both short-term (hourly to daily) and long-term (monthly to yearly) periods. Nitrate concentrations, measured as nitrate-nitrogen in milligrams per liter (mg/L), during drought conditions showed little or no temporal change as groundwater levels declined. During aquifer recharge, extremely rapid changes in concentration occurred at both wells as documented by hourly data. At both sites, nitrate concentrations were affected by recharging surface water as evidenced by nitrate concentrations in groundwater recharge (0.8-1.3 mg/L) that were similar to previously reported values for regional recharging streams. Groundwater nitrate concentrations responded differently at urban and rural sites during groundwater recharge. Concentrations at the rural well (approximately 1.0 mg/L) increased as a result of higher nitrate concentrations in groundwater recharge relative to ambient nitrate concentrations in groundwater, whereas concentrations at the urban well (approximately 2.7 mg/L) decreased as a result of the dilution of higher ambient nitrate concentrations relative to those in groundwater recharge. Notably, nitrate concentrations decreased to as low as 0.8 mg/L at the urban site during recharge but postrecharge concentrations exceeded 3.0 mg/L. A return to higher nitrate concentrations postrecharge indicates mobilization of a localized source of elevated nitrate within the

  12. Spaceliner Class Operability Gains Via Combined Airbreathing/ Rocket Propulsion: Summarizing an Operational Assessment of Highly Reusable Space Transports

    NASA Technical Reports Server (NTRS)

    Nix, Michael B.; Escher, William J. d.

    1999-01-01

    In discussing a new NASA initiative in advanced space transportation systems and technologies, the Director of the NASA Marshall Space Flight Center, Arthur G. Stephenson, noted that, "It would use new propulsion technology, air-breathing engine so you don't have to carry liquid oxygen, at least while your flying through the atmosphere. We are calling it Spaceliner 100 because it would be 100 times cheaper, costing $ 100 dollars a pound to orbit." While airbreathing propulsion is directly named, rocket propulsion is also implied by, "... while you are flying through the atmosphere." In-space final acceleration to orbital speed mandates rocket capabilities. Thus, in this informed view, Spaceliner 100 will be predicated on combined airbreathing/rocket propulsion, the technical subject of this paper. Interestingly, NASA's recently concluded Highly Reusable Space Transportation (HRST) study focused on the same affordability goal as that of the Spaceliner 100 initiative and reflected the decisive contribution of combined propulsion as a way of expanding operability and increasing the design robustness of future space transports, toward "aircraft like" capabilities. The HRST study built on the Access to Space Study and the Reusable Launch Vehicle (RLV) development activities to identify and characterize space transportation concepts, infrastructure and technologies that have the greatest potential for reducing delivery cost by another order of magnitude, from $1,000 to $100-$200 per pound for 20,000 lb. - 40.000 lb. payloads to low earth orbit (LEO). The HRST study investigated a number of near-term, far-term, and very far-term launch vehicle concepts including all-rocket single-stage-to-orbit (SSTO) concepts, two-stage-to-orbit (TSTO) concepts, concepts with launch assist, rocket-based combined cycle (RBCC) concepts, advanced expendable vehicles, and more far term ground-based laser powered launchers. The HRST study consisted of preliminary concept studies, assessments

  13. Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1

    PubMed Central

    Owen, Siân V.; Wenner, Nicolas; Canals, Rocío; Makumi, Angela; Hammarlöf, Disa L.; Gordon, Melita A.; Aertsen, Abram; Feasey, Nicholas A.; Hinton, Jay C. D.

    2017-01-01

    In the past 30 years, Salmonella bloodstream infections have become a significant health problem in sub-Saharan Africa and are responsible for the deaths of an estimated 390,000 people each year. The disease is predominantly caused by a recently described sequence type of Salmonella Typhimurium: ST313, which has a distinctive set of prophage sequences. We have thoroughly characterized the ST313-associated prophages both genetically and experimentally. ST313 representative strain D23580 contains five full-length prophages: BTP1, Gifsy-2D23580, ST64BD23580, Gifsy-1D23580, and BTP5. We show that common S. Typhimurium prophages Gifsy-2, Gifsy-1, and ST64B are inactivated in ST313 by mutations. Prophage BTP1 was found to be a functional novel phage, and the first isolate of the proposed new species “Salmonella virus BTP1”, belonging to the P22virus genus. Surprisingly, ∼109 BTP1 virus particles per ml were detected in the supernatant of non-induced, stationary-phase cultures of strain D23580, representing the highest spontaneously induced phage titer so far reported for a bacterial prophage. High spontaneous induction is shown to be an intrinsic property of prophage BTP1, and indicates the phage-mediated lysis of around 0.2% of the lysogenic population. The fact that BTP1 is highly conserved in ST313 poses interesting questions about the potential fitness costs and benefits of novel prophages in epidemic S. Typhimurium ST313. PMID:28280485

  14. Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1.

    PubMed

    Owen, Siân V; Wenner, Nicolas; Canals, Rocío; Makumi, Angela; Hammarlöf, Disa L; Gordon, Melita A; Aertsen, Abram; Feasey, Nicholas A; Hinton, Jay C D

    2017-01-01

    In the past 30 years, Salmonella bloodstream infections have become a significant health problem in sub-Saharan Africa and are responsible for the deaths of an estimated 390,000 people each year. The disease is predominantly caused by a recently described sequence type of Salmonella Typhimurium: ST313, which has a distinctive set of prophage sequences. We have thoroughly characterized the ST313-associated prophages both genetically and experimentally. ST313 representative strain D23580 contains five full-length prophages: BTP1, Gifsy-2(D23580), ST64B(D23580), Gifsy-1(D23580), and BTP5. We show that common S. Typhimurium prophages Gifsy-2, Gifsy-1, and ST64B are inactivated in ST313 by mutations. Prophage BTP1 was found to be a functional novel phage, and the first isolate of the proposed new species "Salmonella virus BTP1", belonging to the P22virus genus. Surprisingly, ∼10(9) BTP1 virus particles per ml were detected in the supernatant of non-induced, stationary-phase cultures of strain D23580, representing the highest spontaneously induced phage titer so far reported for a bacterial prophage. High spontaneous induction is shown to be an intrinsic property of prophage BTP1, and indicates the phage-mediated lysis of around 0.2% of the lysogenic population. The fact that BTP1 is highly conserved in ST313 poses interesting questions about the potential fitness costs and benefits of novel prophages in epidemic S. Typhimurium ST313.

  15. Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age.

    PubMed

    Karlsson, Caroline L J; Molin, Göran; Fåk, Frida; Johansson Hagslätt, Marie-Louise; Jakesevic, Maja; Håkansson, Åsa; Jeppsson, Bengt; Weström, Björn; Ahrné, Siv

    2011-09-01

    The aim of the present study was to assess the long-term effects of a high-energy-dense diet, supplemented with Lactobacillus plantarum (Lp) or Escherichia coli (Ec), on weight gain, fattening and the gut microbiota in rats. Since the mother's dietary habits can influence offspring physiology, dietary regimens started with the dams at pregnancy and throughout lactation and continued with the offspring for 6 months. The weight gain of group Lp was lower than that of groups C (control) and Ec (P = 0·086). More retroperitoneal adipose tissue (P = 0·030) and higher plasma leptin (P = 0·035) were observed in group Ec compared with group Lp. The viable count of Enterobacteriaceae was higher in group Ec than in group Lp (P = 0·019), and when all animals were compared, Enterobacteriaceae correlated positively with body weight (r 0·428, P = 0·029). Bacterial diversity was lower in group Ec than in groups C (P ≤ 0·05) and Lp (P ≤ 0·05). Firmicutes, Bacteroidetes and Verrucomicrobia dominated in all groups, but Bacteroidetes were more prevalent in group C than in groups Lp (P = 0·036) and Ec (P = 0·056). The same five bacterial families dominated the microbiota of groups Ec and C, and four of these were also present in group Lp. The other five families dominating in group Lp were not found in any of the other groups. Multivariate data analysis pointed in the same directions as the univariate statistics. The present results suggest that supplementation of L. plantarum or E. coli can have long-term effects on the composition of the intestinal microbiota, as well as on weight gain and fattening.

  16. Spontaneous compactification and chiral fermions

    NASA Astrophysics Data System (ADS)

    Frampton, Paul H.; Yamamoto, Katsuji

    The question is addressed of which chiral fermions survive in spontaneously compactified solutions of the generalized Einstein-Yang-Mills field equations for higher even space-time dimensions. First, we study the allowed fermion representations of SU( N) which have no gauge or gravitational chiral anomalies in arbitrary even dimension and show how to find all such representations for the case of totally antisymmetric SU( N) tensors. Second, we look explicitly at monopole-induced spontaneous compactification in six dimensions; here, interesting chiral fermions in four dimensions do not occur easily but instead require highly artificial assignments of quantum numbers under the U(1) gauge group associated with the monopole. Finally, we consider instanton-induced spontaneous compactification in eight dimensions; for this case, we may readily obtain acceptable chiral fermions in four dimensions, including Georgi's three-family SU(11) model.

  17. Antidepressants and Weight Gain

    MedlinePlus

    Diseases and Conditions Depression (major depressive disorder) Can antidepressants cause weight gain? Answers from Daniel K. Hall-Flavin, M.D. Weight gain is a possible side effect of nearly all antidepressants. ...

  18. Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats.

    PubMed

    Baum, Jamie I; Washington, Tyrone A; Shouse, Stephanie A; Bottje, Walter; Dridi, Sami; Davis, Gina; Smith, Dameon

    2016-12-01

    Obesity is a major public health concern and it is essential to identify effective treatments and preventative strategies to stop continued increases in obesity rates. The potential functional roles of the branched chain amino acid leucine make this amino acid an attractive candidate for the treatment and/or prevention of obesity. The objective of this study was to determine if long-term leucine supplementation could prevent the development of obesity and reduce the risk factors for chronic disease in rats fed a high-fat (60 % fat) diet. Male Sprague-Dawley rats (n = 30 per dietary treatment) were meal-fed (3 meals/day) either a control, low-fat diet (LF), control + leucine (LFL), high-fat (HF), or high-fat + leucine (HFL) for 42 days. On day 42, rats were sacrificed at 0, 30, or 90 min postprandial. Animals fed the HF and HFL diets had higher (P < 0.05) final body weights and weight gain compared to animals fed the LF and LFL diets. Leucine supplementation increased epididymal fat mass (P < 0.05) and decreased muscle mass (P < 0.05). There was no effect of leucine supplementation on postprandial glucose or insulin response. However, there was a significant effect (P < 0.05) of diet and time on free fatty acid concentrations. There was no effect of leucine on muscle markers of protein synthesis (4E-BP1, p70S6K) or energy metabolism (Akt, AMPK). Leucine supplementation decreased (P < 0.05) PGC1α expression and increased (P < 0.05) PPARγ expression in skeletal muscle. In conclusion, long-term leucine supplementation does not prevent weight gain, improve body composition, or improve glycemic control in rats fed a high-fat diet.

  19. Spontaneous diaphragm rupture associated with vaginal delivery.

    PubMed

    Hamaji, Masatsugu; Burt, Bryan M; Ali, Syed Osman; Cohen, Daniel M

    2013-08-01

    Spontaneous rupture of the diaphragm associated with vaginal delivery is a rare occurrence, but has high rates of morbidity and mortality. Herein, we present a first uncomplicated case of spontaneous rupture of the diaphragm associated with vaginal delivery, which was treated successfully with surgery via a thoracotomy.

  20. IR Gain Monitor

    NASA Astrophysics Data System (ADS)

    Hilbert, Bryan

    2012-10-01

    The gain of the IR channel of WFC3 will be measured using a series of internal flat fields. Using knowledge gained from ground testing and previous cycles, we propose to collect flat field ramps which will be used to create photon transfer curves and give a measure of the gain.

  1. Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats

    PubMed Central

    Kanyan Enchang, Francis; Nor Hussein, Fuzina

    2017-01-01

    Many studies revealed the potential of honey consumption in controlling obesity. However, no study has been conducted using Malaysian honey. In this study, we investigated the efficacy of two local Malaysian honey types: Gelam and Acacia honey in reducing excess weight gain and other parameters related to obesity. The quality of both honey types was determined through physicochemical analysis and contents of phenolic and flavonoid. Male Sprague-Dawley rats were induced to become obese using high fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks. Significant reductions in excess weight gain and adiposity index were observed in rats fed with Gelam honey compared to HFD rats. Moreover, levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function test, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly when compared to rats fed with HFD only. Similar results were also displayed in rats treated with orlistat, but with hepatotoxicity effects. In conclusion, consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat. PMID:28246535

  2. Multi-layer thick gas electron multiplier (M-THGEM): A new MPGD structure for high-gain operation at low-pressure

    NASA Astrophysics Data System (ADS)

    Cortesi, M.; Rost, S.; Mittig, W.; Ayyad-Limonge, Y.; Bazin, D.; Yurkon, J.; Stolz, A.

    2017-01-01

    The operating principle and performances of the Multi-layer Thick Gaseous Electron Multiplier (M-THGEM) are presented. The M-THGEM is a novel hole-type gaseous electron multiplier produced by multi-layer printed circuit board technology; it consists of a densely perforated assembly of multiple insulating substrate sheets (e.g., FR-4), sandwiched between thin metallic-electrode layers. The electron avalanche processes occur along the successive multiplication stages within the M-THGEM holes, under the action of strong dipole fields resulting from the application of suitable potential differences between the electrodes. The present work focuses on the investigation of two different geometries: a two-layer M-THGEM (either as single or double-cascade detector) and a single three-layer M-THGEM element, tested in various low-pressure He-based gas mixtures. The intrinsically robust confinement of the avalanche volume within the M-THGEM holes provides an efficient reduction of the photon-induced secondary effects, resulting in a high-gain operation over a broad pressure range, even in pure elemental gas. The operational principle, main properties (maximum achievable gain, long-term stability, energy resolution, etc.) under different irradiation conditions, as well as capabilities and potential applications are presented and discussed.

  3. Tailoring Directive Gain for High-Contrast, Wide-Viewing-Angle Organic Light-Emitting Diodes Using Speckle Image Holograpy Metasurfaces.

    PubMed

    Zhou, Lei; Ou, Qing-Dong; Shen, Su; Zhou, Yun; Fan, Yuan-Yuan; Zhang, Jun; Tang, Jian-Xin

    2016-08-31

    Holography metasurfaces have been used to control the propagation of light to an unprecedented level, exhibiting the immense potential for light steering in organic light-emitting diodes (OLEDs). Here, a new approach to tailoring directive gain for high contrast, wide-viewing-angle OLEDs is proposed by implementing a spcekle image holography (SIH) metasurface. The experimental and theoretical results provide the direct proofs that the SIH metasurface can play very important roles not only in releasing the trapped energy flow insides the devices but also in tailoring the wavefronts to the preferred patterns due to its "regional orientation" k-vectors patterns. The resulting power efficiency and external quantum efficiency of the OLEDs using a SIH metasurface are 1.97 and 1.95 times that of the reference device with a standard architecture. Furthermore, the wavefronts of emitted light are delicately modulated in a polarization-independent manner, yielding 2.5 times higher contrast ratio compared to the reference device. This unique engineered directive gain property is also well-retained for the viewing angles varing from normal to titled ±60° without spectral distortion. These results enrich the understanding of light wavefronts control in OLEDs and highlight its potential application in display as well as light steering for other optoelectronics.

  4. Lower weight gain and hepatic lipid content in hamsters fed high fat diets supplemented with white rice protein, brown rice protein, soy protein, and their hydrolysates.

    PubMed

    Zhang, Huijuan; Bartley, Glenn E; Mitchell, Cheryl R; Zhang, Hui; Yokoyama, Wallace

    2011-10-26

    The physiological effects of the hydrolysates of white rice protein (WRP), brown rice protein (BRP), and soy protein (SP) hydrolyzed by the food grade enzyme, alcalase2.4 L, were compared to the original protein source. Male Syrian Golden hamsters were fed high-fat diets containing either 20% casein (control) or 20% extracted proteins or their hydrolysates as the protein source for 3 weeks. The brown rice protein hydrolysate (BRPH) diet group reduced weight gain 76% compared with the control. Animals fed the BRPH supplemented diet also had lower final body weight, liver weight, very low density lipoprotein cholesterol (VLDL-C), and liver cholesterol, and higher fecal fat and bile acid excretion than the control. Expression levels of hepatic genes for lipid oxidation, PPARα, ACOX1, and CPT1, were highest for hamsters fed the BRPH supplemented diet. Expression of CYP7A1, the gene regulating bile acid synthesis, was higher in all test groups. Expression of CYP51, a gene coding for an enzyme involved in cholesterol synthesis, was highest in the BRPH diet group. The results suggest that BRPH includes unique peptides that reduce weight gain and hepatic cholesterol synthesis.

  5. Attenuation in weight gain with high calcium- and dairy-enriched diets is not associated with taste aversion in rats: a comparison with casein, whey, and soy.

    PubMed

    Eller, Lindsay K; Reimer, Raylene A

    2010-10-01

    A systematic evaluation of the effects of calcium (Ca) and protein source on food intake and taste aversion (TA) in rats is lacking. The purpose of this research was twofold: (1) to determine if Sprague-Dawley rats display TA to standard rat chow supplemented with 2.4% Ca and (2) to determine if short (24-hour) and long-term (weekly) food intake and weight gain are altered when rats are given access to diets containing various protein sources (casein, whey, dairy, or soy). Rats were assigned to one of two diet groups to examine high (2.4%) versus low (0.67%) Ca or to one of four groups to examine taste preference of diets where the sole protein was one of casein, soy, whey, or complete dairy. A crossover design was used to ensure rats consumed all test diets. Food intake and behavioral sequence of satiety were measured. There was no TA to the 2.4% Ca diet or to any protein source. Food intake did not differ between the two Ca diets or between the four protein diets. The dairy diet attenuated weekly weight gain compared to all other diets except whey. Overall, this study suggests that the levels of Ca and types of protein used in previous work addressing changes in body weight in rats do not influence food intake or trigger TA.

  6. Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats.

    PubMed

    Samat, Suhana; Kanyan Enchang, Francis; Nor Hussein, Fuzina; Wan Ismail, Wan Iryani

    2017-01-01

    Many studies revealed the potential of honey consumption in controlling obesity. However, no study has been conducted using Malaysian honey. In this study, we investigated the efficacy of two local Malaysian honey types: Gelam and Acacia honey in reducing excess weight gain and other parameters related to obesity. The quality of both honey types was determined through physicochemical analysis and contents of phenolic and flavonoid. Male Sprague-Dawley rats were induced to become obese using high fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks. Significant reductions in excess weight gain and adiposity index were observed in rats fed with Gelam honey compared to HFD rats. Moreover, levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function test, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly when compared to rats fed with HFD only. Similar results were also displayed in rats treated with orlistat, but with hepatotoxicity effects. In conclusion, consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat.

  7. Kinetic and thermodynamic analyses of spontaneous exchange between high-density lipoprotein-bound and lipid-free apolipoprotein A-I.

    PubMed

    Handa, Daisuke; Kimura, Hitoshi; Oka, Tatsuya; Takechi, Yuki; Okuhira, Keiichiro; Phillips, Michael C; Saito, Hiroyuki

    2015-02-03

    It is thought that apolipoprotein A-I (apoA-I) spontaneously exchanges between high-density lipoprotein (HDL)-bound and lipid-free states, which is relevant to the occurrence of preβ-HDL particles in plasma. To improve our understanding of the mechanistic basis for this phenomenon, we performed kinetic and thermodynamic analyses for apoA-I exchange between discoidal HDL-bound and lipid-free forms using fluorescence-labeled apoA-I variants. Gel filtration experiments demonstrated that addition of excess lipid-free apoA-I to discoidal HDL particles promotes exchange of apoA-I between HDL-associated and lipid-free pools without alteration of the steady-state HDL particle size. Kinetic analysis of time-dependent changes in NBD fluorescence upon the transition of NBD-labeled apoA-I from HDL-bound to lipid-free state indicates that the exchange kinetics are independent of the collision frequency between HDL-bound and lipid-free apoA-I, in which the lipid binding ability of apoA-I affects the rate of association of lipid-free apoA-I with the HDL particles and not the rate of dissociation of HDL-bound apoA-I. Thus, C-terminal truncations or mutations that reduce the lipid binding affinity of apoA-I strongly impair the transition of lipid-free apoA-I to the HDL-bound state. Thermodynamic analysis of the exchange kinetics demonstrated that the apoA-I exchange process is enthalpically unfavorable but entropically favorable. These results explain the thermodynamic basis of the spontaneous exchange reaction of apoA-I associated with HDL particles. The altered exchangeability of dysfunctional apoA-I would affect HDL particle rearrangement, leading to perturbed HDL metabolism.

  8. Spontaneous intercalation of long-chain alkyl ammonium into edge-selectively oxidized graphite to efficiently produce high-quality graphene

    PubMed Central

    Wei, Liangming; Wu, Fei; Shi, Diwen; Hu, Changchen; Li, Xiaolin; Yuan, Weien; Wang, Jian; Zhao, Jiang; Geng, Huijuan; Wei, Hao; Wang, Ying; Hu, Nantao; Zhang, Yafei

    2013-01-01

    Mass production of high-quality graphene nanosheets (GNs) is essential for practical applications. We report that oxidation of graphite by low concentration KMnO4 at relatively high temperature (60°C) leads to edge-selectively oxidized graphite (EOG) which preserves the high crystalline graphitic structure on its basal planes while the edges are functionalized by oxygen-containing groups. Long-chain tetradecyl-ammonium salt (C14N+) could be spontaneously intercalated into EOG to form intercalated EOG-C14N+ compounds. Gentle and short-time sonication of EOG-C14N+ in toluene can full exfoliate EOG into edge-oxidized graphene nanosheets (EOGNs) with concentration of 0.67 mg/ml, monolayer population up to 90% and lateral size from 1 μm to >100 μm. The EOG and EOGN films show excellent electrical conductance, which is far superior to their graphene oxide (GO) counterparts. Our method provides an efficient way to produce high-quality GNs, and the resultant EOG also can be directly used for production of multifunctional materials and devices. PMID:24022463

  9. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors.

    PubMed

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO(3) crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  10. Laser diode structures with a saturable absorber for high-energy picosecond optical pulse generation by combined gain-and Q-switching

    NASA Astrophysics Data System (ADS)

    Ryvkin, B. S.; Avrutin, E. A.; Kostamovaara, J. E. K.; Kostamovaara, J. T.

    2017-02-01

    The performance of gain-switched Fabry-Perot asymmetric-waveguide semiconductor lasers with a large equivalent spot size and an intracavity saturable absorber was investigated experimentally and theoretically. The laser with a short (˜20 μm) absorber emitted high-energy afterpulse-free optical pulses in a broad range of injection current pulse amplitudes; optical pulses with a peak power of about 35 W and a duration of about 80 ps at half maximum were achieved with a current pulse with an amplitude of just 8 A and a duration of 1.5 ns. Good quality pulsations were observed in a broad range of elevated temperatures. The introduction of a substantially longer absorber section leads to strong spectral broadening of the output without a significant improvement to pulse energy and peak power.

  11. Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity.

    PubMed

    Shikov, Alexander N; Pozharitskaya, Olga N; Makarova, Marina N; Kovaleva, Maria A; Laakso, Into; Dorman, H J Damien; Hiltunen, Raimo; Makarov, Valery G; Galambosi, Bertalan

    2012-11-15

    The objective of this study was to evaluate the feeding behavior and weight gain in rats with high-calorie diet-induced obesity that are treated with Bergenia crassifolia black and fermented leaves extracts. The daily dietary intake of all treated animals was reduced to 40% compared with the control group on day 22 of the experiment. A significant improvement in glucose tolerance was noted after 7 days of treatment with the Bergenia extracts. In rats treated with an extract of black leaves for 7 days, a significant reduction in the serum triglyceride level, 45% (p<0.05), compared with the control group was observed. However, the treatment did not affect the cholesterol level. Our results provide evidence for the potential use of B. crassifolia as an appetite and energy intake suppressant.

  12. Wideband and high-gain frequency stabilization of a 100-W injection-locked Nd:YAG laser for second-generation gravitational wave detectors

    NASA Astrophysics Data System (ADS)

    Ohmae, Noriaki; Moriwaki, Shigenori; Mio, Norikatsu

    2010-07-01

    Second-generation gravitational wave detectors require a highly stable laser with an output power greater than 100 W to attain their target sensitivity. We have developed a frequency stabilization system for a 100-W injection-locked Nd:YAG (yttrium aluminum garnet) laser. By placing an external wideband electro-optic modulator used as a fast-frequency actuator in the optical path of the slave output, we can circumvent a phase delay in the frequency control loop originating from the pole of an injection-locked slave cavity. Thus, we have developed an electro-optic modulator made of a MgO-doped stoichiometric LiNbO3 crystal. Using this modulator, we achieve a frequency control bandwidth of 800 kHz and a control gain of 180 dB at 1 kHz. These values satisfy the requirement for a laser frequency control loop in second-generation gravitational wave detectors.

  13. Rogue Wave and Breather Structures with "High Frequency" and "Low Frequency" in 𝒫𝒯-Symmetric Nonlinear Couplers with Gain and Loss

    NASA Astrophysics Data System (ADS)

    Yu, Dang-Jun; Zhang, Jie-Fang

    2016-10-01

    Based on the modified Darboux transformation method, starting from zero solution and the plane wave solution, the hierarchies of rational solutions and breather solutions with "high frequency" and "low frequency" of the coupled nonlinear Schrödinger equation in parity-time symmetric nonlinear couplers with gain and loss are constructed, respectively. From these results, some basic characteristics of multi-rogue waves and multi-breathers are studied. Based on the property of rogue wave as the "quantum" of pattern structure in rogue wave hierarchy, we further study the novel structures of the superposed Akhmediev breathers, Kuznetsov-Ma solitons and their combined structures. It is expected that these results may give new insight into the context of the optical communications and Bose-Einstein condensations.

  14. Optical gain in GaAsBi/GaAs quantum well diode lasers

    NASA Astrophysics Data System (ADS)

    Marko, Igor P.; Broderick, Christopher A.; Jin, Shirong; Ludewig, Peter; Stolz, Wolfgang; Volz, Kerstin; Rorison, Judy M.; O'Reilly, Eoin P.; Sweeney, Stephen J.

    2016-07-01

    Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly impact upon the device performance. Suppression of these loss mechanisms promises to lead to highly efficient, uncooled operation of telecommunications lasers, making GaAsBi system a strong candidate for the development of next-generation semiconductor lasers. In this report we present the first experimentally measured optical gain, absorption and spontaneous emission spectra for GaAsBi-based quantum well laser structures. We determine internal optical losses of 10-15 cm-1 and a peak modal gain of 24 cm-1, corresponding to a material gain of approximately 1500 cm-1 at a current density of 2 kA cm-2. To complement the experimental studies, a theoretical analysis of the spontaneous emission and optical gain spectra is presented, using a model based upon a 12-band k.p Hamiltonian for GaAsBi alloys. The results of our theoretical calculations are in excellent quantitative agreement with the experimental data, and together provide a powerful predictive capability for use in the design and optimisation of high efficiency lasers in the infrared.

  15. Optical gain in GaAsBi/GaAs quantum well diode lasers.

    PubMed

    Marko, Igor P; Broderick, Christopher A; Jin, Shirong; Ludewig, Peter; Stolz, Wolfgang; Volz, Kerstin; Rorison, Judy M; O'Reilly, Eoin P; Sweeney, Stephen J

    2016-07-01

    Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly impact upon the device performance. Suppression of these loss mechanisms promises to lead to highly efficient, uncooled operation of telecommunications lasers, making GaAsBi system a strong candidate for the development of next-generation semiconductor lasers. In this report we present the first experimentally measured optical gain, absorption and spontaneous emission spectra for GaAsBi-based quantum well laser structures. We determine internal optical losses of 10-15 cm(-1) and a peak modal gain of 24 cm(-1), corresponding to a material gain of approximately 1500 cm(-1) at a current density of 2 kA cm(-2). To complement the experimental studies, a theoretical analysis of the spontaneous emission and optical gain spectra is presented, using a model based upon a 12-band k.p Hamiltonian for GaAsBi alloys. The results of our theoretical calculations are in excellent quantitative agreement with the experimental data, and together provide a powerful predictive capability for use in the design and optimisation of high efficiency lasers in the infrared.

  16. Optical gain in GaAsBi/GaAs quantum well diode lasers

    PubMed Central

    Marko, Igor P.; Broderick, Christopher A.; Jin, Shirong; Ludewig, Peter; Stolz, Wolfgang; Volz, Kerstin; Rorison, Judy M.; O’Reilly, Eoin P.; Sweeney, Stephen J.

    2016-01-01

    Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly impact upon the device performance. Suppression of these loss mechanisms promises to lead to highly efficient, uncooled operation of telecommunications lasers, making GaAsBi system a strong candidate for the development of next-generation semiconductor lasers. In this report we present the first experimentally measured optical gain, absorption and spontaneous emission spectra for GaAsBi-based quantum well laser structures. We determine internal optical losses of 10–15 cm−1 and a peak modal gain of 24 cm−1, corresponding to a material gain of approximately 1500 cm−1 at a current density of 2 kA cm−2. To complement the experimental studies, a theoretical analysis of the spontaneous emission and optical gain spectra is presented, using a model based upon a 12-band k.p Hamiltonian for GaAsBi alloys. The results of our theoretical calculations are in excellent quantitative agreement with the experimental data, and together provide a powerful predictive capability for use in the design and optimisation of high efficiency lasers in the infrared. PMID:27363930

  17. Spontaneous emission effects in optically pumped x-ray FEL

    SciTech Connect

    Smetanin, I.V.; Grigor`ev, S.V.

    1995-12-31

    An effect of spontaneous emission in both quantum and classical regimes of the optically pumped X-ray free electron laser (FEL) in investigated. The quantum properties of an FEL are determined by the ratio of the separation {h_bar} between the absorption and emission lines (i.e. the quanta emitted) and their effective width {Delta}{epsilon} {eta}={h_bar}/{Delta}{epsilon}. In the conventional classical regime {eta} {much_lt} 1 an electron emits and absorbes a great number of shortwavelength photons over the interaction region, the gain in FEL being the result of these competitive processes. In the quantum limit {eta} {much_gt} 1 the emission and absorption lines are completely separated and thus the FEL becomes a two-level quantum oscillator with a completely inverted active medium. Spontaneous emission causes the electron to leave the range of energies where resonant interaction with the laser field occurs, thus effectively reducing the number of particles that take part in generating the induced X-ray signal. This effect is found to be crucial for lasing in optically pumped X-ray FEL. The characteristic relaxation times are calculated for both classical and quantum FEL regimes. It is shown that spontaneous emission results in FEL electron beam threshold current, which is of rather high value. An optimal range of pumping laser intensities is determined.

  18. Evaluation of spontaneous DNA damage in lymphocytes of healthy adult individuals from high-level natural radiation areas of Kerala in India.

    PubMed

    Kumar, P R Vivek; Cheriyan, V D; Seshadri, M

    2012-05-01

    Inhabitants of the high-level natural radiation areas (>1 mSv year(-1)) of Kerala in southwest India were evaluated for basal damage (spontaneous DNA strand breaks and alkali-labile sites) by the alkaline comet assay and oxidative DNA damage (ENDO III- and hOGG1-sensitive sites) by the enzyme-modified comet assay. Of the 67 adult male subjects studied, 45 were from high-level natural radiation areas and 22 subjects were from a nearby normal-level natural radiation area (≤1 mSv year(-1)). Basal damage due to the age and residential area (normal-level natural radiation area/high-level natural radiation areas) of the donors showed significant interaction (P < 0.001) when all subjects were analyzed using a general linear model (GLM). In subgroup analysis, basal damage increased with age in subjects from the normal-level natural radiation area (P = 0.02), while a significant negative correlation (P = 0.002) was observed in subjects from high-level natural radiation areas. Further, basal damage in elderly subjects from high-level natural radiation areas was significantly (P < 0.001) lower compared to the subjects from the normal-level natural radiation area. Oxidative DNA damage was not influenced by age, smoking habit or residential area in the entire sample. However, in a subgroup analysis, hOGG1-sensitive sites showed a significant increase with age in subjects from high-level natural radiation areas (P = 0.005). ENDO III-sensitive sites increased with natural radiation exposure in subjects from high-level natural radiation areas (P = 0.02), but when stratified according to smoking, a significant increase was observed only in smokers (P = 0.01). To the best of our knowledge, this is the first study on basal and oxidative DNA damage in healthy adults of this population. However, our findings need more validation in a larger study population.

  19. High (≥6.5) Spontaneous and Persistent Urinary pH Is Protective of Renal Function at Baseline and during Disease Course in Idiopathic Membranous Nephropathy

    PubMed Central

    Bazzi, Claudio; Tagliabue, Elena; Raimondi, Sara; Rizza, Virginia; Casellato, Daniela; Nangaku, Masaomi

    2015-01-01

    Metabolic acidosis correction in advanced renal failure slows renal function decline attributed to tubulointerstitial damage (TID) reduction. No study evaluated if spontaneous baseline high urinary pH (UpH) is renoprotective in patients with normal renal function and without metabolic acidosis. The study tested this hypothesis in idiopathic membranous nephropathy (IMN). Eighty-five patients (follow-up 81 ± 54 months) measured UpH, serum creatinine, eGFR, protein/creatinine ratio, fractional excretion of albumin, IgG, α1-microglobulin, and urinary N-acetyl-β-D-glucosaminidase (β-NAG)/creatinine ratio. Twenty-eight patients (33%) had UpH ≥ 6.5 and 57 (67%) pH < 6.5; high versus low UpH patients had significantly lower values of the tubulointerstitial damage (TID) markers FE α1m and β-NAG and significantly better baseline renal function. These differences persisted over time in a subset of 38 patients with 5 measurements along 53 ± 26 months. In 29 patients with nephrotic syndrome (NS) treated with supportive therapy (follow-up: 80 ± 52 months) renal function was stable in 10 high and significantly worse in 19 low UpH patients. Steroids + cyclophosphamide treatment in 35 NS patients masks the renoprotection of high UpH. Conclusions. In IMN high and persistent UpH is associated with reduction of the proteinuric markers of tubulointerstitial damage and baseline better renal function in all patients and in NS patients treated only with supportive therapy during disease course. The factors associated with high pH-dependent renoprotection were lower values of TID markers, eGFR ≥ 60 mL/min, BP < 140/90 mmHg, and age < 55 years. PMID:26294975

  20. Spontaneous closure of stoma.

    PubMed

    Pandit, Narendra; Singh, Harjeet; Kumar, Hemanth; Gupta, Rajesh; Verma, G R

    2016-11-01

    Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems, but it rarely undergoes spontaneous closure, without surgical intervention. Two male patients presented to our emergency surgical department with acute abdominal pain. One of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the perforation. The other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy; the patient underwent second loop ileostomy, this time for complicated intestinal obstruction. To our surprise, both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks, respectively, without any consequences. Spontaneous stoma closure is a rare and interesting event. The exact etiology for spontaneous closure remains unknown, but it may be hypothesized to result from slow retraction of the stoma, added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

  1. Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain

    NASA Astrophysics Data System (ADS)

    Graham, S. A.; Siewerdsen, J. H.; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.

    2005-04-01

    Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200 - 400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

  2. Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice.

    PubMed

    Matsui, Yukari; Hirasawa, Yasushi; Sugiura, Takahiro; Toyoshi, Tohru; Kyuki, Kohei; Ito, Mikio

    2010-01-01

    In an acute treatment experiment, metformin (150, 300 mg/kg, per os (p.o.)) markedly reduced the consumption of a high-fat diet (HFD) (45 kcal% fat-containing diet) for 2 h after the HFD was given to the fasted male C57BL/6J (B6) mice. In addition, metformin at a higher dose increased plasma active glucagon-like peptide-1 (GLP-1) levels at 1 h after the HFD was given. On the other hand, pioglitazone (12 mg/kg, p.o.) slightly increased the food intake but did not affect active GLP-1 levels when given at 6 and 12 mg/kg, p.o. In a long-team experiment for 9 weeks, metformin treatment (0.25, 0.5% in the HFD) resulted in reduction of body weight gain and HFD intake. When wet weights of various body fat pads of each mouse were measured at 9 weeks after treatment, metformin markedly decreased these weights. However, pioglitazone treatment (0.01, 0.02% in the HFD) did not have obvious effects on these parameters. Oral glucose tolerance test was carried out after 20-h fasting at 4 weeks post-treatment. Whereas metformin treatment (0.25, 0.5%) markedly improved glucose intolerance, pioglitazone treatment (0.02%) slightly improved this parameter. At 9 weeks, both metformin and pioglitazone markedly improved hyperglycemia and hyperinsulinemia. Metformin treatment also improved hyperleptinemia, whereas pioglitazone was ineffective. These results indicate that metformin reduces body weight gain and improves glucose intolerance in HFD-induced obese diabetic B6 mice.

  3. Gaining Cyber Dominance

    DTIC Science & Technology

    2015-01-01

    2014 Carnegie Mellon University Gaining Cyber Dominance Software Engineering Institute Carnegie Mellon University NETCOM G3/5/7 TREX January 2015...JAN 2015 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Gaining Cyber Dominance 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...2014) 4 GCD Overview January 2015 © 2014 Carnegie Mellon University FY15 Initiatives Gaining Cyber Dominance Program • Army topology development

  4. Self-assembly, highly modified spontaneous emission and energy transfer properties of LaPO4:Ce3+, Tb3+ inverse opals.

    PubMed

    Zhu, Yongsheng; Sun, Zhipeng; Yin, Ze; Song, Hongwei; Xu, Wen; Wang, Yunfeng; Zhang, Ligong; Zhang, Hanzhuang

    2013-06-14

    The modification of photonic crystals (PCs) on photoluminescence of rare earth (RE) ions has attracted considerable interest, however, the modification of PCs on energy transfer (ET) processes of two separate RE centers has not been investigated yet. In this paper, three-dimensional Ce(3+), Tb(3+)-codoped LaPO4 inverse opal PCs (IOPCs) were fabricated by the PMMA colloidal template method. The modification of the photonic stop band (PSB) on emission spectra and the dynamics of the 5d-4f transition of Ce(3+) and the 4f-4f transition of Tb(3+) ions were systematically studied. It is interesting to observe that the spontaneous decay rates (SDR) of (5)D4-(7)F5 in the IOPCs were suppressed as highly as 173% in contrast to the reference ground powder samples (REF) due to the modification of the effective refractive index (n(eff)). The energy transfer (ET) rate of Ce(3+) to Tb(3+) did not change in the IOPCs, however, the energy migration rate among Tb(3+) ions was largely restrained. It is also significant to observe that, in the IOPCs, the temperature quenching and radiation trapping of photoluminescence were greatly suppressed due to the periodic empty cavity structure of IOPCs, which is significant for high-power light sources and laser devices.

  5. Adaptive allocation of attentional gain.

    PubMed

    Scolari, Miranda; Serences, John T

    2009-09-23

    Humans are adept at distinguishing between stimuli that are very similar, an ability that is particularly crucial when the outcome is of serious consequence (e.g., for a surgeon or air-traffic controller). Traditionally, selective attention was thought to facilitate perception by increasing the gain of sensory neurons tuned to the defining features of a behaviorally relevant object (e.g., color, orientation, etc.). In contrast, recent mathematical models counterintuitively suggest that, in many cases, attentional gain should be applied to neurons that are tuned away from relevant features, especially when discriminating highly similar stimuli. Here we used psychophysical methods to critically evaluate these "ideal observer" models. The data demonstrate that attention enhances the gain of the most informative sensory neurons, even when these neurons are tuned away from the behaviorally relevant target feature. Moreover, the degree to which an individual adopted optimal attentional gain settings by the end of testing predicted success rates on a difficult visual discrimination task, as well as the amount of task improvement that occurred across repeated testing sessions (learning). Contrary to most traditional accounts, these observations suggest that the primary function of attentional gain is not to enhance the representation of target features per se, but instead to optimize performance on the current perceptual task. Additionally, individual differences in gain suggest that the operating characteristics of low-level attentional phenomena are not stable trait-like attributes and that variability in how attention is deployed may play an important role in determining perceptual abilities.

  6. Efficiency of food utilization during body weight gain in dormice (Glis glis).

    PubMed

    Melnyk, R B; Boshes, M

    1980-06-01

    During spontaneous body weight gain in dormice, Glis glis, progressive increases in the efficiency of food utilization as defined by weight gain (g)/food intake (g), and parallel increases in mean daily food intake were observed. Towards the end of the weight gain period, there was an abrupt drop in feeding efficiency with no significant change in food intake even when the latter was expressed relative to an index of each animal's "metabolic mass" (body weightkg0.62). Animals whose body weight increases followed a return to ad lib feeding after prolonged food restriction showed marked decreases in feeding efficiency from initially high values which were independent of changes in food intake. These results are discussed in relation to the sliding set point concept of body weight regulation in hibernators.

  7. High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production.

    PubMed

    Blum, Ailisa; Benfield, Aurélie H; Stiller, Jiri; Kazan, Kemal; Batley, Jacqueline; Gardiner, Donald M

    2016-05-01

    Fusarium head blight and crown rot, caused by the fungal plant pathogen Fusarium graminearum, impose a major threat to global wheat production. During the infection, plants are contaminated with mycotoxins such as deoxynivalenol (DON), which can be toxic for humans and animals. In addition, DON is a major virulence factor during wheat infection. However, it is not fully understood how DON production is regulated in F. graminearum. In order to identify regulators of DON production, a high-throughput mutant screen using Fluorescence Activated Cell Sorting (FACS) of a mutagenised TRI5-GFP reporter strain was established and a mutant over-producing DON under repressive conditions identified. A gain-of-function mutation in the F. graminearum adenylyl cyclase (FAC1), which is a known positive regulator of DON production, was identified as the cause of this phenotype through genome sequencing and segregation analysis. Our results show that the high-throughput mutant screening procedure developed here can be applied for identification of fungal proteins involved in diverse processes.

  8. Giant enhancement of optical high-order sideband generation and their control in a dimer of two cavities with gain and loss

    NASA Astrophysics Data System (ADS)

    Li, Jiahui; Li, Jiahua; Xiao, Qian; Wu, Ying

    2016-06-01

    Parity-time (PT ) symmetric systems, which rely on the balanced gain-loss condition and render the Hamiltonian non-Hermitian, have provided a new platform to engineer effective light-matter interactions in recent years. Here we explore the high-order sideband features of the output fields obtained from a PT -symmetric optical system consisting of a passive nonlinear cavity coupled to an active linear cavity. By employing a perturbation technique, we derive analytic formulas used to determine the nonlinear transmission coefficient of optical second-order sideband in this structure. Using experimentally achievable parameters, it is clearly shown that the efficiency of the second-order sideband generation can be greatly enhanced in the PT -symmetric dimer, extremely in the vicinity of the transition point from unbroken- to broken-PT regimes. Moreover, we further analyzed the influences of the system parameters, including the photon-tunneling rate between two cavities, Kerr nonlinearity strength, and optical detuning, on the second-order sideband generation. Subsequently we investigate the higher-order sideband output spectrum by numerical simulations, where the sideband amplitude also is largely enhanced in the PT -symmetric arrangement, compared with the passive-passive double-cavity system. Our obtained results provide a new avenue for acquiring optical high-order sidebands and operating light, which may inspire further applications in chip-scale optical communications and optical frequency combs.

  9. Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice.

    PubMed

    Márquez-Aguirre, A L; Camacho-Ruíz, R M; Gutiérrez-Mercado, Y K; Padilla-Camberos, E; González-Ávila, M; Gálvez-Gastélum, F J; Díaz-Martínez, N E; Ortuño-Sahagún, D

    2016-12-01

    Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperglycemia by 25 % and liver steatosis by 40 %. Interestingly, unfractionated fructans (HFD+F) decreased glucose and triglycerides (TG), whereas fractionated fructans with a higher dp (HFD+LcF) decreased TG but not glucose; in contrast, HFD+ScF decreased glucose but not TG. Our findings suggest that both higher and lower dp agave fructans have complementary effects in metabolic disorders related to obesity. These findings may contribute to the development of improved food supplements with a specific ratio combination of fructans with different dps.

  10. Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters.

    PubMed

    Lomba, Almudena; Martínez, J Alfredo; García-Díaz, Diego F; Paternain, Laura; Marti, Amelia; Campión, Javier; Milagro, Fermín I

    2010-01-01

    Experimental studies have demonstrated that dietary macronutrient distribution plays an important role in insulin regulation, a risk factor associated to obesity, diabetes and other metabolic disorders. To assess whether the macronutrient composition of the diet could be related to obesity onset by affecting the epigenetic regulation of gene expression, we investigated in rats the metabolic effects of two pair-fed isocaloric diets: control (rich in carbohydrates) and high fat diet (rich in fat; HFD). Compared to controls, HFD induced higher weight gain and adiposity and impaired glucose tolerance, which was accompanied by a slight increase in adiponectin levels and liver steatosis. Epididymal adipose tissue expression of the fatty acid synthase (FASN) gene and NADH dehydrogenase (ubiquinone) 1β-subcomplex 6 (NDUFB6) were significantly reduced in HFD group. These variations in mRNA levels were accompanied by changes in the methylation patterns of several CpG islands located in the promoter region of these genes. However, no correlations were found between gene expression and the methylation status. These results suggest that high fat intake produces overweighted rats independently of total energy intake. These diets could also induce some epigenetic changes in the promoters of key genes that could influence gene expression and may be behind metabolic alterations.

  11. Weight gain - unintentional

    MedlinePlus

    ... trying to do so can have many causes. Metabolism slows down as you age . This can cause weight gain if you eat too much, eat the wrong foods, or do not get enough exercise. Drugs that can cause weight gain include: Birth ...

  12. Invention and Gain Analysis.

    ERIC Educational Resources Information Center

    Weber, Robert J.; Dixon, Stacey

    1989-01-01

    Gain analysis is applied to the invention of the sewing needle as well as different sewing implements and modes of sewing. The analysis includes a two-subject experiment. To validate the generality of gain heuristics and underlying switching processes, the invention of the assembly line is also analyzed. (TJH)

  13. Digital automatic gain control

    NASA Technical Reports Server (NTRS)

    Uzdy, Z.

    1980-01-01

    Performance analysis, used to evaluated fitness of several circuits to digital automatic gain control (AGC), indicates that digital integrator employing coherent amplitude detector (CAD) is best device suited for application. Circuit reduces gain error to half that of conventional analog AGC while making it possible to automatically modify response of receiver to match incoming signal conditions.

  14. Suppression of shot noise and spontaneous radiation in electron beams

    SciTech Connect

    Litvinenko,V.

    2009-08-23

    Shot noise in the electron beam distribution is the main source of noise in high-gain FEL amplifiers, which may affect applications ranging from single- and multi-stage HGHG FELs to an FEL amplifier for coherent electron cooling. This noise also imposes a fundamental limit of about 10{sup 6} on FEL gain, after which SASE FELs saturate. There are several advantages in strongly suppressing this shot noise in the electron beam, and the corresponding spontaneous radiation. For more than a half-century, a traditional passive method has been used successfully in practical low-energy microwave electronic devices to suppress shot noise. Recently, it was proposed for this purpose in FELs. However, being passive, the method has some significant limitations and is hardly suitable for the highly inhomogeneous beams of modern high-gain FELs. I present a novel active method of suppressing, by many orders-of-magnitude, the shot noise in relativistic electron beams. I give a theoretical description of the process, and detail its fundamental limitation.

  15. Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice.

    PubMed

    Jeon, Seon-Min; Kim, Hye-Jin; Woo, Myoung-Nam; Lee, Mi-Kyung; Shin, Young Chul; Park, Yong Bok; Choi, Myung-Sook

    2010-09-01

    An ethanol extract of fucoxanthin-rich seaweed was examined for its effectiveness as a nutraceutical for body fat-lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi-purified high-fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin-rich seaweed ethanol extract (Fx-SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx-SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high-fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol-regulating enzyme were also lowered by Fx-SEE supplement. Concentrations of plasma high-density lipoprotein-cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx-SEE groups than in the high-fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx-SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption.

  16. Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats

    PubMed Central

    Su-Hong, Chen; Qi, Chen; Bo, Li; Jian-Li, Gao; Jie, Su; Gui-Yuan, Lv

    2015-01-01

    Radix Paeoniae Alba (Baishao, RPA) has long been used in traditional Chinese medicine formulation to treat hypertension by repression the hyperfunction of liver. However, whether the RPA itself has the antihypertensive effect or not is seldom studied. This study was to evaluate the protective effect of RPA on hypertensive rats. Alcohol in conjunction with a high fat diet- (ACHFD-) induced hypertensive rats and spontaneously hypertensive rats (SHR) was constantly received either RPA extract (25 or 75 mg/kg) or captopril (15 mg/kg) all along the experiments. As a result, RPA extract (75 mg/kg) could significantly reduce systolic blood pressure of both ACHFD-induced hypertensive rats and SHR after 9-week or 4-week treatment. In ACHFD-induced hypertensive rats, the blood pressure was significantly increased and the lipid profiles in serum including triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly deteriorated. Also, hepatic damage was manifested by a significant increase in alanine transaminase (ALT) and aspartate transaminase (AST) in serum. The RPA extract significantly reversed these parameters, which revealed that it could alleviate the liver damage of rats. In SHR, our result suggested that the antihypertensive active of RPA extract may be related to its effect on regulating serum nitric oxide (NO) and endothelin (ET) levels. PMID:25784949

  17. High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice.

    PubMed

    Pilvi, Taru K; Korpela, Riitta; Huttunen, Minna; Vapaatalo, Heikki; Mervaala, Eero M

    2007-11-01

    An inverse relationship between Ca intake and BMI has been found in several studies. It has been suggested that Ca affects adipocyte metabolism via suppressing 1,25-dihydroxycholecalciferol (1,25(OH)2-D3) and decreases fat absorption. We studied the effect of Ca and milk proteins (whey and casein) on body weight in C57Bl/6J mice. Male mice, age 9 weeks, were divided into three groups (ten mice per group) receiving modified high-fat (60% of energy) diets. Two groups received a high-Ca diet (1.8% calcium carbonate (CaCO3)), with casein or whey protein (18% of energy), and one group received a low-Ca diet (0.4% CaCO3) with casein for 21 weeks. Food intake was measured daily and body weight twice per week. Body fat content (by dual-energy X-ray absorptiometry) of all mice and faecal Ca and fat excretion of seven mice/group were measured twice during the study. Final body weight (44.1 (SEM 1.1) g) and body fat content (41.6 (SEM 0.6) %) were significantly lower (P < 0.05) in the high-Ca whey group than in the low-Ca casein group (48.1 (SEM 0.8) g and 44.9 (SEM 0.8) %). Body weight and body fat content of the high-Ca casein group did not differ significantly from the low-Ca casein group even though serum 1,25(OH)2-D3 levels were significantly lower (P < 0.001) in both high-Ca groups than in the low-Ca casein group. Thus changes in serum 1,25(OH)2-D3 do not seem to affect body weight in this animal model. There was a significant difference in fat excretion between the high-Ca whey and low-Ca casein groups (3.9 (SEM 0.9) % in the high-Ca whey v. 1.4 (SEM 0.2) % in the low-Ca casein group; P < 0.05), which may partly explain the effect on body weight.

  18. Prismatic louver active façades for natural illumination and thermal energy gain in high-rise and commercial buildings

    NASA Astrophysics Data System (ADS)

    Vlachokostas, A.; Volkmann, C.; Madamopoulos, N.

    2013-06-01

    High-rise and commercial buildings in urban centers present a great challenge in terms of their energy consumption. Due to maximization of rentable square footage, the preferred urban façade system over the past 50 years has been the "curtain wall", only a few inches thick and comprised of modular steel or aluminum framing and predominant glass infills. The perceived Achilles heel of these modern glass façade systems is their thermal inefficiency: They are inadequate thermal barriers and exhibit excessive solar gain. The excessive solar gain has a negative impact on lighting and cooling loads of the entire building. This negative impact will be further exacerbated with rising energy costs. However, rather than view the glass façade's uncontrolled solar gain merely as a weakness contributing to higher energy consumption, the condition could indeed be considered as related to an energy solution. These glass façades can be retrofitted to operate as a provider of daylight and energy for the rest of the building, taking advantage of the overexposure to the sun. With today's technology, the sun's abundant renewable energy can be the driving force for the energy transition of these building envelopes. Illumination, thermal energy, and electricity production can be directly supplied from the sun, and when correctly and efficiently managed, they can lead to a significantly less energy-intensive building stock. We propose a multi-purpose, prismatic, louver-based façade to perform both daylight and thermal energy harvesting with a goal of offering a better daylight environment for the occupants, and reduce the energy consumption and carbon footprint of the building. While decentralized air-conditioning units are commonly accepted as façade "plug-ins", such decentralization could be utilized with more benefits by passively managing the interior space conditions, without using any extra power. Just as living organisms respond and adapt to the environmental changes in

  19. Underrepresented Minority High School and College Students Report STEM-Pipeline Sustaining Gains After Participating in the Loma Linda University Summer Health Disparities Research Program

    PubMed Central

    Salto, Lorena M.; Riggs, Matt L.; Delgado De Leon, Daisy; Casiano, Carlos A.; De Leon, Marino

    2014-01-01

    An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math) pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU) Summer Health Disparities Research Program on high school (HS) and undergraduate (UG) student participants. The primary focus of our summer research experience (SRE) is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical workforce

  20. Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program.

    PubMed

    Salto, Lorena M; Riggs, Matt L; Delgado De Leon, Daisy; Casiano, Carlos A; De Leon, Marino

    2014-01-01

    An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math) pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU) Summer Health Disparities Research Program on high school (HS) and undergraduate (UG) student participants. The primary focus of our summer research experience (SRE) is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical workforce

  1. Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet.

    PubMed

    Lepore, Saverio Massimo; Morittu, Valeria Maria; Celano, Marilena; Trimboli, Francesca; Oliverio, Manuela; Procopio, Antonio; Di Loreto, Carla; Damante, Giuseppe; Britti, Domenico; Bulotta, Stefania; Russo, Diego

    2015-01-01

    The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.

  2. Dynamic stomatal behavior and its role in carbon gain during lightflecks of a gap phase and an understory Piper species acclimated to high and low light.

    PubMed

    Tinoco-Ojanguren, Clara; Pearcy, Robert W

    1992-11-01

    Steady-state and dynamic stomatal and assimilation responses to light transients were characterized in sun- and shade-acclimated plants of Piper auritum, a pioneer tree, and Piper aequale a shade-tolerant shrub from a tropical forest at Los Tuxtlas, Veracruz, México. Despite essentially identical steady-state responses of stomatal conductance to PFD of P. aequale and P. auritum shade plants, the dynamic responses to lightflecks were markedly different and depended on the growth regime. For both species from both growth environments, the increase in stomatal conductance occurring in response to a lightfleck continued long after the lightfleck itself so that the maximum stomatal conductance was not reached until 20-40 min after the lightfleck. Closing then occurred until stomatal conductance returned to near its original value before the lightfleck. Plants that were grown under light regimes similar to those of their natural habitat (high light for P. auritum and shade for P. aequale) had large maximum excursions of stomatal conductance and slower closing than opening responses. Plants grown under the opposite conditions had smaller excursions of stomatal conductance, especially in P. auritum, and more symmetrical opening and closing. The large and hysteretic response of stomatal conductance of P. aequale shade plants to a lightfleck was shown to improve carbon gain during subsequent lightflecks by 30-200%, depending on lightfleck duration. In contrast the very small stomatal response to lightflecks in P. auritum shade plants, resulted in no significant improvement in use of subsequent lightflecks.

  3. Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice.

    PubMed

    Everard, Amandine; Geurts, Lucie; Van Roye, Marie; Delzenne, Nathalie M; Cani, Patrice D

    2012-01-01

    Obesity and related metabolic disorders such as insulin resistance and type 2 diabetes are associated with a low-grade inflammatory state possibly through changes in gut microbiota composition and the development of higher plasma lipopolysaccharide (LPS) levels, i.e. metabolic endotoxemia. Various phytochemical compounds have been investigated as potential tools to regulate these metabolic features. Humulus lupulus L. (hops) contains several classes of compounds with anti-inflammatory potential. Recent evidence suggests that hops-derived compounds positively impact adipocyte metabolism and glucose tolerance in obese and diabetic rodents via undefined mechanisms. In this study, we found that administration of tetrahydro iso-alpha acids (termed META060) to high-fat diet (HFD)-fed obese and diabetic mice for 8 weeks reduced body weight gain, the development of fat mass, glucose intolerance, and fasted hyperinsulinemia, and normalized insulin sensitivity markers. This was associated with reduced portal plasma LPS levels, gut permeability, and higher intestinal tight junction proteins Zonula occludens-1 and occludin. Moreover, META060 treatment increased the plasma level of the anti-inflammatory cytokine interleukin-10 and decreased the plasma level of the pro-inflammatory cytokine granulocyte colony-stimulating factor. In conclusion, this research allows us to decipher a novel mechanism contributing to the positive effects of META060 treatment, and supports the need to investigate such compounds in obese and type 2 diabetic patients.

  4. Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

    PubMed Central

    Lepore, Saverio Massimo; Morittu, Valeria Maria; Celano, Marilena; Trimboli, Francesca; Oliverio, Manuela; Procopio, Antonio; Di Loreto, Carla; Damante, Giuseppe; Britti, Domenico; Bulotta, Stefania; Russo, Diego

    2015-01-01

    The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders. PMID:26798341

  5. The effect of a county's public high school summer remediation program on student gains on end-of-course standard of learning tests in Algebra I, Biology, Chemistry, Geometry and World History and Geography II

    NASA Astrophysics Data System (ADS)

    Aiken, Brenda L.

    The Commonwealth of Virginia requires high school students to receive a passing grade in core courses and a passing score on End-of-Course Standards of Learning (EOC SOL) tests to receive verified credits that lead to a Virginia high school diploma. These tests are believed to accurately reflect what students should know and be able to do in order to experience success in their endeavors beyond high school. For some students remediation is required to experience success on EOC SOL tests. This study sought to determine the effect of a County's public high school summer remediation program on student gains on EOC SOL tests in Algebra I, Biology, Chemistry, Geometry, and World History and Geography II. Specifically, the purpose of the study sought to determine the following: (a) If significant gains were made by students who attended the summer remediation program; (b) If significant gains were made by students who did not attend the summer remediation program; (c) If there were differences in gain scores of students who attended and those who did not attend the summer remediation program; and (d) If there were differences in gain scores among students who attended the summer remediation program related to school site, gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. The results of the study indicate that students who attended and those who did not attend the summer remediation program made significant gains. However, the gains for students who attended the summer remediation program were significantly greater than the gains made by students who did not attend. The study also found that there were no significant differences in gain scores among students who attended the summer remediation program related to gender, ethnicity, learning ability group, socioeconomic status, and level of English proficiency. There were significant differences in Algebra I gain scores related to school site. Recommendations for

  6. Indoor acoustic gain design

    NASA Astrophysics Data System (ADS)

    Concha-Abarca, Justo Andres

    2002-11-01

    The design of sound reinforcement systems includes many variables and usually some of these variables are discussed. There are criteria to optimize the performance of the sound reinforcement systems under indoor conditions. The equivalent acoustic distance, the necessary acoustic gain, and the potential acoustic gain are parameters which must be adjusted with respect to the loudspeaker array, electric power and directionality of loudspeakers, the room acoustics conditions, the distance and distribution of the audience, and the type of the original sources. The design and installation of front of the house and monitoring systems have individual criteria. This article is about this criteria and it proposes general considerations for the indoor acoustic gain design.

  7. Spontaneous combustion of hydrogen

    NASA Technical Reports Server (NTRS)

    Nusselt, Wilhelm; Pothmann, PH

    1923-01-01

    It is shown by the author's experiments that hydrogen which escapes to the atmosphere through openings in the system may burn spontaneously if it contains dust. Purely thermal reasoning can not account for the combustion. It seems to be rather an electrical ignition. In order to determine whether the cause of the spontaneous ignition was thermo-chemical, thermo-mechanical, or thermo-electrical, the experiments in this paper were performed.

  8. Swimming eliminates the weight gain and abdominal fat associated with ovariectomy in the retired breeder rat despite high-fat diet selection.

    PubMed

    Melton, S A; Hegsted, M; Keenan, M J; Zhang, Y; Morris, S; Potter Bulot, L; O'Neil, C E; Morris, G S

    2000-08-01

    The effects of swim-training on choice of dietary fat, carbohydrate or protein, weight gain, energy intake, and energy efficiency were examined in ovariectomized and sham-operated retired breeder rats. After a 3 week training period of increased duration, rats swam for 75 min per session (5 days per week) for 4 weeks. Ovariectomized rats gained more weight than sham rats, while swimming reduced weight gain and abdominal fat. As a percentage of total intake, macronutrient choices (weight and energy) were similar for all groups, ovariectomized animals consumed more food and more energy, compared with sham animals. All rats freely chose the majority of their food (g) as carbohydrate and the majority of energy (kJ) as fat. Results indicate that a moderate intensity training program of swimming prevented the weight gain following ovariectomy in older rats despite their excessive caloric intake of fat.

  9. Effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder.

    PubMed

    Kim, Jungyun; Park, Heamen; Yu, Seong-Lan; Jee, Sungju; Cheon, Keun-Ah; Song, Dong Ho; Kim, Seung Jun; Im, Woo-Young; Kang, Jaeku

    2016-10-01

    The current treatment of choice for attention deficit hyperactivity disorder (ADHD) is pharmacotherapy. A search for new treatment options is underway, however, as the wide application of drugs to the general population of patients with ADHD is limited by side effects and the variance of pharmacokinetic effects of the drugs in each patient. In the present study, we applied repetitive transcranial magnetic stimulation (rTMS), a non-invasive treatment used in a number of other psychiatric disorders, to spontaneously hypertensive rats (SHRs), an animal model of ADHD, in order to assess the efficacy of the treatment in modifying behavioural symptoms as well as levels of dopamine, noradrenaline, serotonin, and brain-derived neurotrophic factor (BDNF). A total of fifteen sessions of high-frequency rTMS treatment were administered. Behavioural symptoms were observed using open field, Y-maze, and elevated plus-maze tests. Upon completion of the experiments, rats were sacrificed, and the neurochemical changes in brain tissue were analysed using high performance liquid chromatography and Western blotting. The SHRs treated with rTMS tended to exhibit less locomotor activity in the open field test over the course of treatment, but there was no improvement in inattention as measured by the Y-maze test. Furthermore, BDNF concentration increased and noradrenaline concentration decreased in the prefrontal cortex of SHRs treated with rTMS. The results of the present preclinical study indicate that rTMS may constitute a new modality of treatment for patients with ADHD, through further evaluation of specific treatment parameters as well as safety and efficacy in humans are required.

  10. A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice

    PubMed Central

    Lamont, B J; Waters, M F; Andrikopoulos, S

    2016-01-01

    Background/Objectives: Dietary guidelines for the past 20 years have recommended that dietary fat should be minimized. In contrast, recent studies have suggested that there could be some potential benefits for reducing carbohydrate intake in favor of increased fat. It has also been suggested that low-carbohydrate diets be recommended for people with type 2 diabetes. However, whether such diets can improve glycemic control will likely depend on their ability to improve β-cell function, which has not been studied. The objective of the study was to assess whether a low-carbohydrate and therefore high-fat diet (LCHFD) is beneficial for improving the endogenous insulin secretory response to glucose in prediabetic New Zealand Obese (NZO) mice. Methods: NZO mice were maintained on either standard rodent chow or an LCHFD from 6 to 15 weeks of age. Body weight, food intake and blood glucose were assessed weekly. Blood glucose and insulin levels were also assessed after fasting and re-feeding and during an oral glucose tolerance test. The capacity of pancreatic β-cells to secrete insulin was assessed in vivo with an intravenous glucose tolerance test. β-Cell mass was assessed in histological sections of pancreata collected at the end of the study. Results: In NZO mice, an LCHFD reduced plasma triglycerides (P=0.001) but increased weight gain (P<0.0001), adipose tissue mass (P=0.0015), high-density lipoprotein cholesterol (P=0.044) and exacerbated glucose intolerance (P=0.013). Although fasting insulin levels tended to be higher (P=0.08), insulin secretory function in LCHFD-fed mice was not improved (P=0.93) nor was β-cell mass (P=0.75). Conclusions: An LCHFD is unlikely to be of benefit for preventing the decline in β-cell function associated with the progression of hyperglycemia in type 2 diabetes. PMID:26878317

  11. End-season daily weight gains as rationale for targeted selective treatment against gastrointestinal nematodes in highly exposed first-grazing season cattle.

    PubMed

    Merlin, Aurélie; Chauvin, Alain; Lehebel, Anne; Brisseau, Nadine; Froger, Sébastien; Bareille, Nathalie; Chartier, Christophe

    2017-03-01

    A two-year study was carried out to assess the feasibility of a targeted selective treatment to control gastrointestinal nematodes (GIN) in 24 groups of first grazing season (FGS) cattle. A two-step procedure aiming at defining exposure risk at group level and at identifying the most infected individuals within groups through measurement of the average daily weight gain (ADWG) at housing was used. The first step was to define retrospectively, by grazing management practices (GMP) indicators, two levels of groups' exposure to GIN determined by anti O. ostertagi antibody ODR level (cut-off 0.7). For the low level of exposure, no relationship between parasitological parameters and heifer growth was seen, whereas for the high level ADWG was negatively correlated with increasing Ostertagia ODR values. The best classification was obtained with an expert system modelling the number of Ostertagia L3 generations on plots. GMP input for the expert system included standard data (turnout/housing data and supplementary feeding amount) combined with paddock rotation planning and monthly temperatures. The threshold of 3 successive generations of L3 or more on plots allowed identifying the groups according to low or high infection exposure level, except two groups that were misidentified as being highly exposed. In the second step, individual ADWG was found to be negatively associated with Ostertagia ODR in heifers from groups classified as highly exposed (≥3 generations of L3). In these groups, sensitivity and specificity of ADWG thresholds were calculated for several individual Ostertagia ODR thresholds. The best compromise between sensitivity (i.e., correctly treating the heifers that need to be treated) and specificity (i.e., not treating animals that should not be treated) was equivalent respectively to 76% and 56% (AUC≈0.7) and was reached using an end-season ADWG threshold of 683g/day to detect animals exhibiting an Ostertagia ODR cut-off at 0.93. Other ADWG thresholds

  12. Asthma Triggers: Gain Control

    MedlinePlus

    ... of Page Additional resources An Introduction to Indoor Air Quality: Biological Pollutants Help Your Child Gain Control Over ... exhaust, smoke, road dust and factory emissions. Outdoor air quality is also affected by pollen from plants, crops ...

  13. Preventing Weight Gain

    MedlinePlus

    ... body composition gradually shifts — the proportion of muscle decreases and the proportion of fat increases. This shift slows their metabolism, making it easier to gain weight. In addition, some people become less physically ...

  14. Three-dimensional analysis of harmonic generation in self-amplified spontaneous emission.

    SciTech Connect

    Huang, Z.; Kim, K.-J.

    1999-09-01

    In a high-gain free-electron laser, strong bunching at the fundamental wavelength can drive substantial harmonic bunching and sizable power levels at the harmonic frequencies. In this paper, we investigate the three-dimensional evolution of the harmonic fields based on the coupled Maxwell-Vlasov equations that take into account the nonlinear harmonic interaction. Each harmonic field is the sum of a self-amplified term and a term driven by the nonlinear harmonic interaction. In the exponential gain regime, the growth rate of the dominant nonlinear term is much faster than that of the self-amplified harmonic field. As a result, the gain length and the transverse profile of the first few harmonics are completely determined by those of the fundamental. A percentage of the fundamental power level is found at the third harmonic frequency right before saturation for the current self-amplified spontaneous emission projects.

  15. StAR expression and the long-term aldosterone response to high-potassium diet in Wistar-Kyoto and spontaneously hypertensive rats.

    PubMed

    Peters, Barbara; Teubner, Philipp; Clausmeyer, Susanne; Puschner, Tanja; Maser-Gluth, Christiane; Wrede, Hans-Josef; Kränzlin, Bettina; Peters, Jörg

    2007-01-01

    ANG II and potassium are known to increase steroidogenic acute regulatory protein (StAR) levels. However, a corresponding increase in StAR mRNA levels has so far been observed only in response to ANG II. We therefore studied the regulation of adrenal StAR mRNA expression in the context of dietary potassium-stimulated aldosterone production. Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were fed a diet containing either 1 or 4% KCl for 5 days. The high-potassium diet increased StAR mRNA levels within the zona glomerulosa in both strains, as demonstrated by in situ hybridization. However, aldosterone production increased in WKY but not in SHR (WKY: from 22.8 +/- 4.8 to 137 +/- 25 ng/100 ml, P < 0.001, vs. SHR: from 29 +/- 3.8 to 51 +/- 10.2 ng/100 ml, not significant). This increase was associated with an increase in Cyp11b2 mRNA levels in WKY (3-fold; P < 0.001) but not in SHR. In both strains, the 4% KCl diet was associated with increased plasma renin-independent aldosterone production, as indicated by the marked increase of the aldosterone-to-renin ratios (from 1.4 +/- 0.3 to 9 +/- 3 in WKY and from 3 +/- 1 to 14 +/- 5 in SHR; P < 0.002). We conclude that an increase of StAR mRNA levels within the outer cortex is involved in the long-term adrenal response to potassium. This increase alone is not sufficient to increase aldosterone production in the presence of normal Cyp11b2 mRNA levels.

  16. Preference for Western diet coadapts in High Runner mice and affects voluntary exercise and spontaneous physical activity in a genotype-dependent manner.

    PubMed

    Acosta, Wendy; Meek, Thomas H; Schutz, Heidi; Dlugosz, Elizabeth M; Garland, Theodore

    2017-02-01

    Do animals evolve (coadapt) to choose diets that positively affect their performance abilities? We addressed this question from a microevolutionary perspective by examining preference for Western diet (WD: high in fat and sugar, but lower in protein) versus standard rodent chow in adults of both sexes from 4 lines of mice selectively bred for high levels of voluntary wheel running (High Runner or HR lines) and 4 non-selected control (C) lines. We also assessed whether food preference or substitution affects physical activity (wheel running and/or spontaneous physical activity [SPA] in the attached home cages). In experiment 1 (generation 56), mice were given 6days of wheel acclimation (as is used routinely to pick breeders in the selection experiment) prior to a 2-day food choice trial. In experiment 2 (generation 56), 17days of wheel acclimation allowed mice to reach a stable level of daily running, followed by a 7-day food-choice trial. In experiment 3 (generation 58), mice had 6days of wheel acclimation with standard chow, after which half were switched to WD for two days. In experiment 1, WD was highly preferred by all mice, with somewhat greater preference in male C mice. In experiment 2, wheel running increased and SPA decreased continuously for the first 14days of adult wheel testing, followed by 3-day plateaus in both. During the subsequent 7-day food choice trial, HR mice of both sexes preferred WD significantly more than did C mice; moreover, wheel running increased in all groups except males from C lines, with the increase being significantly greater in HR than C, while SPA declined further in all groups. In experiment 3, the effect of being switched to WD depended on both linetype and sex. On standard chow, only HR females showed a significant change in wheel running during nights 7+8, increasing by 10%. In contrast, when switched to WD, C females (+28%), HR females (+33%), and HR males (+10%) all significantly increased their daily wheel

  17. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.

    PubMed

    Iffiú-Soltész, Zsuzsa; Wanecq, Estelle; Lomba, Almudena; Portillo, Maria P; Pellati, Federica; Szöko, Eva; Bour, Sandy; Woodley, John; Milagro, Fermin I; Alfredo Martinez, J; Valet, Philippe; Carpéné, Christian

    2010-04-01

    Benzylamine is found in Moringa oleifera, a plant used to treat diabetes in traditional medicine. In mammals, benzylamine is metabolized by semicarbazide-sensitive amine oxidase (SSAO) to benzaldehyde and hydrogen peroxide. This latter product has insulin-mimicking action, and is involved in the effects of benzylamine on human adipocytes: stimulation of glucose transport and inhibition of lipolysis. This study examined whether chronic, oral administration of benzylamine could improve glucose tolerance and the circulating lipid profile without increasing oxidative stress in overweight and pre-diabetic mice. The benzylamine diffusion across the intestine was verified using everted gut sacs. Then, glucose handling and metabolic markers were measured in mice rendered insulin-resistant when fed a high-fat diet (HFD) and receiving or not benzylamine in their drinking water (3600micromol/(kgday)) for 17 weeks. HFD-benzylamine mice showed lower body weight gain, fasting blood glucose, total plasma cholesterol and hyperglycaemic response to glucose load when compared to HFD control. In adipocytes, insulin-induced activation of glucose transport and inhibition of lipolysis remained unchanged. In aorta, benzylamine treatment partially restored the nitrite levels that were reduced by HFD. In liver, lipid peroxidation markers were reduced. Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased. In spite of the putative deleterious nature of the hydrogen peroxide generated during amine oxidation, and in agreement with its in vitro insulin-like actions found on adipocytes, the SSAO-substrate benzylamine could be considered as a potential oral agent to treat metabolic syndrome.

  18. Tunability of optical gain (SWIR region) in type-II In0.70Ga0.30As/GaAs0.40Sb0.60 nano-heterostructure under high pressure

    NASA Astrophysics Data System (ADS)

    Nirmal, H. K.; Yadav, Nisha; Dalela, S.; Rathi, Amit; Siddiqui, M. J.; Alvi, P. A.

    2016-06-01

    The interest in applying an external pressure on a nano-heterostructure is to attempt to extract more information about the electronic structure through distortion of the electronic structure. This paper reports the tunability of the optical gain under the high pressure effect in M-shaped type-II In0.70Ga0.30As/GaAs0.40Sb0.60 symmetric lasing nano-heterostructure designed for SWIR generation. In order to simulate the optical gain, the heterostructure has been modeled with the help of six band k.p method. The 6×6 diagonalized k.p Hamiltonian has been solved to evaluate the valence sub-bands (i.e. light and heavy hole energies); and then optical matrix elements and optical gain within TE (Transverse Electric) mode has been calculated. For the injected carrier density of 5×1012/cm2, the optimized optical gain within TE mode is as high as ~9000/cm at the wavelength of ~1.95 μm, thus providing a very important alternative material system for the generation of SWIR wavelength region. The application of very high pressure (2, 5 and 8 GPa) on the structure along [110] direction shows that the gain as well as lasing wavelength both approach to higher values. Thus, the structure can be tuned externally by the application of high pressure within the SWIR region.

  19. Controlling gain one photon at a time.

    PubMed

    Schwartz, Gregory W; Rieke, Fred

    2013-05-14

    Adaptation is a salient property of sensory processing. All adaptational or gain control mechanisms face the challenge of obtaining a reliable estimate of the property of the input to be adapted to and obtaining this estimate sufficiently rapidly to be useful. Here, we explore how the primate retina balances the need to change gain rapidly and reliably when photons arrive rarely at individual rod photoreceptors. We find that the weakest backgrounds that decrease the gain of the retinal output signals are similar to those that increase human behavioral threshold, and identify a novel site of gain control in the retinal circuitry. Thus, surprisingly, the gain of retinal signals begins to decrease essentially as soon as background lights are detectable; under these conditions, gain control does not rely on a highly averaged estimate of the photon count, but instead signals from individual photon absorptions trigger changes in gain. DOI:http://dx.doi.org/10.7554/eLife.00467.001.

  20. Experimental study of a modulated beam AlGaAs/GaAs diode amplifier operating in the highly saturated gain regime

    SciTech Connect

    D'yachkov, N V; Bogatov, A P; Gushchik, T I; Drakin, A E

    2014-11-30

    The variation in the modulation parameters of an optical signal in a diode power amplifier has been studied experimentally. The experimental data obtained agree well with theory that takes into account nonlinear interaction between fields in the gain medium of a laser through inversion beating. It is shown that the dominant type of output signal modulation is phase modulation, whose depth depends on the amplitude – phase coupling coefficient of the gain medium of the amplifier and the nature of the modulation (the phase relationships between the spectral components) of the output signal. (lasers)

  1. Spontaneous Perforation of Pyometra

    PubMed Central

    Yildizhan, Begüm; Uyar, Esra; Şişmanoğlu, Alper; Güllüoğlu, Gülfem; Kavak, Zehra N.

    2006-01-01

    Pyometra is the accumulation of purulent material in the uterine cavity. Its reported incidence is 0.01−0.5% in gynecologic patients; however, as far as elderly patients are concerned, its incidence is 13.6% [3]. The most common cause of pyometra is malignant diseases of genital tract and the consequences of their treatment (radiotherapy). Other causes are benign tumors like leiomyoma, endometrial polyps, senile cervicitis, cervical occlusion after surgery, puerperal infections, and congenital cervical anomalies. Spontaneous rupture of the uterus is an extremely rare complication of pyometra. To our knowledge, only 21 cases of spontaneous perforation of pyometra have been reported in English literature since 1980. This paper reports an additional case of spontaneous uterine rupture. PMID:17093350

  2. Biomodal spontaneous fission

    SciTech Connect

    Hulet, E.K. )

    1989-09-26

    Investigations of mass and kinetic-energy distributions from spontaneous fission have been extended in recent years to an isotope of element 104 and, for half-lives, to an isotope of element 108. The results have been surprising in that spontaneous fission half-lives have turned out to be much longer than expected and mass and kinetic- energy distributions were found to abruptly shift away from those of the lighter actinides, showing two modes of fission. These new developments have caused a re-evaluation of our understanding of the fission process, bringing an even deeper appreciation of the role played by nuclear shell effects upon spontaneous fission properties. 16 refs., 10 figs.

  3. Scintillator high-gain avalanche rushing photoconductor active-matrix flat panel imager: Zero-spatial frequency x-ray imaging properties of the solid-state SHARP sensor structure

    SciTech Connect

    Wronski, M.; Zhao, W.; Tanioka, K.; DeCrescenzo, G.; Rowlands, J. A.

    2012-11-15

    Purpose: The authors are investigating the feasibility of a new type of solid-state x-ray imaging sensor with programmable avalanche gain: scintillator high-gain avalanche rushing photoconductor active matrix flat panel imager (SHARP-AMFPI). The purpose of the present work is to investigate the inherent x-ray detection properties of SHARP and demonstrate its wide dynamic range through programmable gain. Methods: A distributed resistive layer (DRL) was developed to maintain stable avalanche gain operation in a solid-state HARP. The signal and noise properties of the HARP-DRL for optical photon detection were investigated as a function of avalanche gain both theoretically and experimentally, and the results were compared with HARP tube (with electron beam readout) used in previous investigations of zero spatial frequency performance of SHARP. For this new investigation, a solid-state SHARP x-ray image sensor was formed by direct optical coupling of the HARP-DRL with a structured cesium iodide (CsI) scintillator. The x-ray sensitivity of this sensor was measured as a function of avalanche gain and the results were compared with the sensitivity of HARP-DRL measured optically. The dynamic range of HARP-DRL with variable avalanche gain was investigated for the entire exposure range encountered in radiography/fluoroscopy (R/F) applications. Results: The signal from HARP-DRL as a function of electric field showed stable avalanche gain, and the noise associated with the avalanche process agrees well with theory and previous measurements from a HARP tube. This result indicates that when coupled with CsI for x-ray detection, the additional noise associated with avalanche gain in HARP-DRL is negligible. The x-ray sensitivity measurements using the SHARP sensor produced identical avalanche gain dependence on electric field as the optical measurements with HARP-DRL. Adjusting the avalanche multiplication gain in HARP-DRL enabled a very wide dynamic range which encompassed all

  4. Spontaneous sarcomere dynamics

    NASA Astrophysics Data System (ADS)

    Günther, Stefan; Kruse, Karsten

    2010-12-01

    Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state. We analyze a model for sarcomere dynamics, which is based on a force-dependent detachment rate of myosin from actin. Our numerical bifurcation analysis of the spontaneous sarcomere dynamics reveals notably Hopf bifurcations, canard explosions, and gluing bifurcations. We discuss possible implications for experiments.

  5. Spontaneous bilateral tubal pregnancy.

    PubMed

    Wali, Aisha Syed; Khan, Rozilla Sadia

    2012-02-01

    With the increase in incidence of ectopic pregnancy over the decades, bilateral ectopic pregnancy is also increasing. It is usually associated with assisted reproductive techniques (ART) but in recent years few cases of spontaneous bilateral ectopic pregnancy have been reported. Gynaecologists should be aware of this and that ultrasonography has limitations in diagnosis. In cases of ectopic pregnancy where contralateral adnexa is not clearly identified on ultrasound and fertility needs to be conserved, patient should be managed by experts in well equipped centres. A case of spontaneous bilateral tubal pregnancy that remained undiagnosed till laparotomy, is described.

  6. High-gain subnanowatt power consumption hybrid complementary logic inverter with WSe2 nanosheet and ZnO nanowire transistors on glass.

    PubMed

    Shokouh, Seyed Hossein Hosseini; Pezeshki, Atiye; Ali Raza, Syed Raza; Lee, Hee Sung; Min, Sung-Wook; Jeon, Pyo Jin; Shin, Jae Min; Im, Seongil

    2015-01-07

    A 1D-2D hybrid complementary logic inverter comprising of ZnO nanowire and WSe2 nanosheet field-effect transistors (FETs) is fabricated on glass, which shows excellent static and dynamic electrical performances with a voltage gain of ≈60, sub-nanowatt power consumption, and at least 1 kHz inverting speed.

  7. Should I Gain Weight?

    MedlinePlus

    ... If you're having trouble with your body image, talk about how you feel with someone you like and trust who's been through it — maybe a parent, doctor, counselor, coach, or teacher. continue It's the Growth, Not the Gain No ...

  8. Phase control in an open Λ-type system with spontaneously generated coherence

    NASA Astrophysics Data System (ADS)

    Cui, Ni; Fan, Xi-Jun; Li, Ai-Yun; Liu, Cheng-Pu; Gong, Shang-Qing; Xu, Zhi-Zhan

    2007-03-01

    This paper investigates the control role of the relative phase between the probe and driving fields on the gain, dispersion and populations in an open Λ system with spontaneously generated coherence (SGC). It shows that by adjusting the value of the relative phase, a change from lasing with inversion to lasing without inversion can be realized; the values and frequency spectrum regions of the inversionless gain and dispersion can be obviously varied; high refractive index with zero absorption and electromagnetically induced transparency can be achieved. It is also found that when the driving field is resonant, the shapes of the dispersion and the gain curves versus the probe detuning are very similar if the relative phase of the dispersion lags π/2 than that of the gain, however for the off-resonant driving field the similarity will disappear; the gain, dispersion and populations are periodical functions of the relative phase, the modulation period is always 2π the contribution of SGC to the inversionless gain and dispersion is much larger than that of the dynamically induced coherence.

  9. Spontaneous transverse colon volvulus

    PubMed Central

    Sana, Landolsi; Ali, Gassara; Kallel, Helmi; Amine, Baklouti; Ahmed, Saadaoui; Mohamed Ali, Elouer; Wajdi, Chaeib; Saber, Mannaï

    2013-01-01

    We report a case of spontaneous transverse colon volvulus in a young healthy woman. It constitutes an unusual case since it occurred in a young healthy woman with a subacute onset and no aetiological factor has been found. Its diagnosis is still challenging. Prompt recognition with emergency intervention constitutes the key to successful outcome. PMID:23785565

  10. Spontaneous transverse colon volvulus.

    PubMed

    Sana, Landolsi; Ali, Gassara; Kallel, Helmi; Amine, Baklouti; Ahmed, Saadaoui; Ali, Elouer Mohamed; Wajdi, Chaeib; Saber, Mannaï

    2013-01-01

    We report a case of spontaneous transverse colon volvulus in a young healthy woman. It constitutes an unusual case since it occurred in a young healthy woman with a subacute onset and no aetiological factor has been found. Its diagnosis is still challenging. Prompt recognition with emergency intervention constitutes the key to successful outcome.

  11. Design of Silicon Photonic Crystal Waveguides for High Gain Raman Amplification Using Two Symmetric Transvers-Electric-Like Slow-Light Modes

    NASA Astrophysics Data System (ADS)

    Hsiao, Yi-Hua; Iwamoto, Satoshi; Arakawa, Yasuhiko

    2013-04-01

    We designed silicon photonic crystal (PhC) waveguides (WGs) for efficient silicon Raman amplifiers and lasers. We adopted narrow-width WGs to utilize two symmetric transvers-electric-like (TE-like) guided modes, which permit efficient external coupling for both the pump and Stokes waves. Modifying the size and shape of air holes surrounding the line-defect WG structures could tune the frequency difference between these two modes, at the Brillouin-zone edge, to match the Raman shift of silicon. Thus, small group velocities are also available both for pump and Stokes waves simultaneously, which results in a large enhancement of Raman gain. The enhancement factor of the Raman gain in the designed structure is more than 100 times that reported previously.

  12. Model based prediction of the existence of the spontaneous cochlear microphonic

    NASA Astrophysics Data System (ADS)

    Ayat, Mohammad; Teal, Paul D.

    2015-12-01

    In the mammalian cochlea, self-sustaining oscillation of the basilar membrane in the cochlea can cause vibration of the ear drum, and produce spontaneous narrow-band air pressure fluctuations in the ear canal. These spontaneous fluctuations are known as spontaneous otoacoustic emissions. Small perturbations in feedback gain of the cochlear amplifier have been proposed to be the generation source of self-sustaining oscillations of the basilar membrane. We hypothesise that the self-sustaining oscillation resulting from small perturbations in feedback gain produce spontaneous potentials in the cochlea. We demonstrate that according to the results of the model, a measurable spontaneous cochlear microphonic must exist in the human cochlea. The existence of this signal has not yet been reported. However, this spontaneous electrical signal could play an important role in auditory research. Successful or unsuccessful recording of this signal will indicate whether previous hypotheses about the generation source of spontaneous otoacoustic emissions are valid or should be amended. In addition according to the proposed model spontaneous cochlear microphonic is basically an electrical analogue of spontaneous otoacoustic emissions. In certain experiments, spontaneous cochlear microphonic may be more easily detected near its generation site with proper electrical instrumentation than is spontaneous otoacoustic emission.

  13. Low body weight gain, low white blood cell count and high serum ferritin as markers of poor nutrition and increased risk for preterm delivery.

    PubMed

    Hsu, Wen-Yin; Wu, Cheng-Hsuan; Hsieh, Charles Tsung-Che; Lo, Hui-Chen; Lin, Jen-Shiou; Kao, Mei-Ding

    2013-01-01

    This study determined factors of preterm delivery in Taiwan. Healthy women (n=520, age 29.1±4.2 y) at 8-12 weeks of pregnancy were recruited from prenatal clinics. Background information, anthropometrics, biochemical parameters, and dietary intake, collected by 24 h-recall were obtained from the first, second, and third trimesters to delivery. Clinical outcomes of neonates were also collected. The results show that 53.7% of women were primiparous and that the incidence of preterm delivery was 6.2%. Body weight gains in the first trimester and throughout pregnancy were significantly lower in mothers with preterm delivery (preterm group) than in mothers with term delivery (term group, p<0.05). Maternal cholesterol intake, circulating white blood cell counts (WBC) and serum albumin were significantly lower and that serum magnesium and ferritin were significantly higher in the preterm group than in the term group. Maternal weight gain was positively correlated with caloric and nutrient intake (p<0.05). Neonatal birth weight was positively correlated with maternal weight gain and intakes of protein and phosphate during pregnancy; with intakes of calories, vitamin B-1 and B-2 in the first trimester; and with intakes of calcium, magnesium, iron and zinc, as well as circulating WBC in the third trimester. However, neonatal birth weight was negatively correlated with serum iron in the third trimester and with serum iron and ferritin at the time of delivery. In conclusion, maternal weight gain in early pregnancy and WBC, mineral intake and iron status in late pregnancy seem to be major factors affecting delivery and neonatal outcomes.

  14. Design of a high-gain laser diode-array pumped Nd:YAG Alternating Precessive Slab Amplifier (APS-Amplifier)

    NASA Technical Reports Server (NTRS)

    Coyle, D. Barry

    1991-01-01

    In the design of space qualifiable laser systems for ranging and altimetry, such as NASA's Geodynamic Laser Ranging System (GLRS), the transmitter must be kept small, powerful yet efficient, and must consist of as few components as possible. A novel preamplifier design is examined which requires no external beam steering optics, yielding a compact component with simple alignment procedures. The gains achieved are comparable to multipass zigzag amplifiers using two or more sets of external optics for extra passes through the amplifying medium.

  15. Microchannel plate modal gain variations with temperature

    NASA Technical Reports Server (NTRS)

    Slater, David C.; Timothy, J. G.

    1993-01-01

    Measurements of the modal gain of two high-gain curved-channel microchannel plates (MCPs) at various operating temperatures are presented. Both MCPs were fabricated from the Long Life glass with 12-micron diam channels on 15-micron centers. The modal gain was found to decrease with increasing temperature at a rate of -0.1 percent C. This reduction of gain with temperature is attributed primarily to an axial temperature gradient along each MCP channel creating a nonuniform electric field within the channel that lowers the effective output gain. A lowering of the secondary electron yield resulting from increased phonon scattering of secondary electrons released within the walls of the MCP channels was assessed, but was found to have a negligible contribution to the drop in gain with temperature.

  16. Making the most of fMRI at 7 T by suppressing spontaneous signal fluctuations.

    PubMed

    Bianciardi, Marta; van Gelderen, Peter; Duyn, Jeff H; Fukunaga, Masaki; de Zwart, Jacco A

    2009-01-15

    The presence of spontaneous BOLD fMRI signal fluctuations in human grey matter compromises the detection and interpretation of evoked responses and limits the sensitivity gains that are potentially available through coil arrays and high field systems. In order to overcome these limitations, we adapted and improved a recently described correlated noise suppression method (de Zwart et al., 2008), demonstrating improved precision in estimating the response to ultra-short visual stimuli at 7 T. In this procedure, the temporal dynamics of spontaneous signal fluctuations are estimated from a reference brain region outside the area targeted with the stimulus. Rather than using the average signal in this region as regressor, as proposed in the original method, we used principal component analysis to derive multiple regressors in order to optimally describe nuisance signals (e.g. spontaneous fluctuations) and separate these from evoked activity in the target region. Experimental results obtained from application of the original method showed a 66% improvement in estimation precision. The novel, enhanced version of the method, using 18 PCA-derived noise regressors, led to a 160% increase in precision. These increases were relative to a control condition without noise suppression, which was simulated by randomizing the time-course of the nuisance-signal regressor(s) without altering their power spectrum. The increase of estimation precision was associated with decreased autocorrelation levels of the residual errors. These results suggest that modeling of spontaneous fMRI signal fluctuations as multiple independent sources can dramatically improve detection of evoked activity, and fully exploit the potential sensitivity gains available with high field technology.

  17. Brazilian Multicentre Study on Preterm Birth (EMIP): Prevalence and Factors Associated with Spontaneous Preterm Birth

    PubMed Central

    Passini, Renato; Cecatti, Jose G.; Lajos, Giuliane J.; Tedesco, Ricardo P.; Nomura, Marcelo L.; Dias, Tabata Z.; Haddad, Samira M.; Rehder, Patricia M.; Pacagnella, Rodolfo C.; Costa, Maria L.; Sousa, Maria H.

    2014-01-01

    Background Preterm birth rate is increasing and is currently a worldwide concern. The purpose of this study was to estimate the prevalence of preterm birth in a sample of health facilities in Brazil and to identify the main risk factors associated with spontaneous preterm births. Methods and Findings This was a multicentre cross sectional study on preterm births in 20 referral obstetric hospitals with a case-control component to identify factors associated with spontaneous preterm birth. Surveillance was implemented at all centres to identify preterm births. For eligible consenting women, data were collected through a post-delivery questionnaire completed with information from all mother-newborn medical records until death or discharge or at a maximum of 60 days post-delivery, whichever came first. The risk of spontaneous preterm birth was estimated with OR and 95%CI for several predictors. A non-conditional logistic regression analysis was then performed to identify independently associated factors. The overall prevalence of preterm birth was 12.3%. Among them, 64.6% were spontaneous and 35.4% therapeutic. In the case-control component, 2,682 spontaneous preterm births were compared to a sample of 1,146 term births. Multivariate analyses identified the following as risk factors for spontaneous preterm birth among women with at least one previous birth: a previous preterm birth (ORadj = 3.19, 2.30–4.43), multiple pregnancy (ORadj = 29.06, 8.43–100.2), cervical insufficiency (ORadj = 2.93, 1.07–8.05), foetal malformation (ORadj = 2.63, 1.43–4.85), polyhydramnios (ORadj = 2.30, 1.17–4.54), vaginal bleeding (ORadj = 2.16, 1.50–3.11), and previous abortion (ORadj = 1.39, 1.08–1.78). High BMI (ORadj = 0.94, 0.91–0.97) and weight gain during gestation (ORadj = 0.92, 0.89–0.95) were found to be protective factors. Conclusions The preterm birth rate in these health facilities in Brazil is high and spontaneous preterm

  18. Gain Shift Corrections at Chi-Nu

    SciTech Connect

    Brown, Tristan Brooks; Devlin, Matthew James

    2016-08-30

    Ambient conditions have the potential to cause changes in liquid scintillator detector gain that vary with time and temperature. These gain shifts can lead to poor resolution in both energy as well as pulse shape discrimination. In order to correct for these shifts in the Chi-Nu high energy array, a laser system has been developed for calibration of the pulse height signals.

  19. Complying with physician gain-sharing restrictions.

    PubMed

    O'Hare, P K

    1998-05-01

    Many IDSs are considering implementing gain-sharing programs as a way to motivate their physicians to provide high-quality, cost-effective services. Before embarking on such programs, however, IDSs need to understand the legal requirements associated with such programs to ensure that the gain-sharing arrangement is in compliance with Federal law.

  20. A Qualitative Analysis of the Spontaneous Volunteer Response to the 2013 Sudan Floods: Changing the Paradigm.

    PubMed

    Albahari, Amin; Schultz, Carl H

    2017-03-08

    Introduction While the concept of community resilience is gaining traction, the role of spontaneous volunteers during the initial response to disasters remains controversial. In an attempt to resolve some of the debate, investigators examined the activities of a spontaneous volunteer group called Nafeer after the Sudan floods around the city of Khartoum in August of 2013. Hypothesis Can spontaneous volunteers successfully initiate, coordinate, and deliver sustained assistance immediately after a disaster?